
                                SEQUENCE LISTING

<110> GLAXOSMITHKLINE LLC

<120> NOVEL ANTIBODIES
  

<130> PU65124

<150> 61/640,796          
<151> 2012-05-01  

<160> 10

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR Heavy Chain

<400> 1
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 2
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR Light Chain

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Glu Ser Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Thr Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 3
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR Fc Disabled Heavy Chain

<400> 3
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 4
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR IgG4 (PE) Heavy Chain

<400> 4
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445     


<210> 5
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR IgG4(PE)N297A Heavy Chain

<400> 5
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445     


<210> 6
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PanELR IgG4(PE)N297S Heavy Chain

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Asp Leu Tyr Ser Gly Gly Gly Tyr Thr Phe Tyr Ser Glu Asn Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gly Tyr Asp Arg Thr Trp Phe Ala His Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Ser Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445     


<210> 7
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding PanELR Fc disabled Heavy
      Chain

<400> 7
caggtccagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc aactactgga tcgtgtgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggagac ctgtacagcg gcggcggcta caccttctac 180
agcgagaact tcaagggcag ggtgactatg acccgggaca ccagcacctc taccgtgtac 240
atggagctga gcagcctgag gtcagaggat accgccgtgt actactgtgc caggagcggc 300
tacgacagga cttggttcgc ccactggggc cagggcaccc tggtgaccgt cagctcagcc 360
agcaccaaag gccccagcgt gttccccctg gctcccagca gcaaaagcac cagcggcggc 420
accgccgccc tgggctgcct ggtcaaggac tacttccccg agcccgtgac cgtgagctgg 480
aatagcggcg ccctgacaag cggcgtgcac accttccccg ccgtgctcca gtctagcggc 540
ctgtacagcc tgagcagcgt ggtgacagtg cctagcagca gcctgggcac ccagacctac 600
atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt cgaacccaag 660
agctgcgaca agacccacac ctgcccacct tgccccgcac ccgaactcgc cggcgcccct 720
agcgtcttcc tgttcccacc caagcccaag gacaccctga tgatcagcag gacccccgag 780
gtgacctgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt caactggtac 840
gtggacggcg tggaggtgca caacgccaag accaagccca gggaggagca gtacaactcc 900
acctacaggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cgggaaggag 960
tacaagtgca aggtgagcaa caaggccctg cccgccccca tcgagaaaac catcagcaag 1020
gccaaaggcc agcccagaga gcctcaggtg tataccctgc ccccaagcag ggacgagctg 1080
accaagaacc aggtgagcct gacctgcctg gtgaagggct tctatcccag cgacattgcc 1140
gtggagtggg agagcaacgg acagcccgag aacaactaca agaccacccc ccccgtcctg 1200
gatagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag caggtggcag 1260
cagggcaacg tgtttagctg tagcgtgatg cacgaggccc tccacaacca ctacacccag 1320
aagtccctga gcctgagccc cggcaag                                     1347

<210> 8
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding PanELR IgG4 (PE) Heavy
      Chain

<400> 8
caggtgcagc tggtgcagag cggcgcagag gtgaagaaac ccggcgcttc cgtgaaggtg 60
agctgtaagg ccagcggcta caccttcacc aactactgga tcgtgtgggt gaggcaggcc 120
cccggccagg gcctggagtg gatgggcgac ctgtacagcg ggggcggcta caccttctac 180
agcgagaact tcaagggcag ggtgaccatg actagggaca cctccaccag caccgtgtac 240
atggagctgt ccagcctgag gagcgaggac accgccgtgt attactgcgc ccggagcggc 300
tacgatagga cttggttcgc ccactggggc cagggcaccc tggtcaccgt gagcagcgct 360
agcaccaaag gccctagcgt gttccccctg gccccctgct ctaggagcac atctgagagc 420
acagccgccc tgggctgcct ggtgaaggac tactttcccg agcccgtgac cgtgtcttgg 480
aacagcggag cactcaccag cggcgtgcac accttccctg ccgtgctgca gagcagcggc 540
ctgtacagcc tgagcagcgt ggtgaccgtg ccaagcagca gcctgggcac caagacctac 600
acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggagagcaaa 660
tacggacccc cctgcccccc ctgccccgcc cccgagtttg aaggaggccc cagcgtgttc 720
ctgttccccc ccaagcccaa ggacaccctg atgatcagca ggacccccga agtgacctgc 780
gtggtggtgg acgtgagcca ggaggacccc gaagtgcagt tcaactggta cgtggacggc 840
gtcgaggtgc acaacgccaa gaccaagccc agagaggagc agttcaacag cacctacagg 900
gtggtgtcag tgctcaccgt gctgcatcag gactggctga acggcaagga gtacaagtgc 960
aaggtcagca acaagggcct gcccagcagc atcgagaaga ccatcagcaa ggccaagggc 1020
cagccaaggg agccccaggt ctataccctg ccccccagcc aggaggagat gaccaagaac 1080
caggtgtccc tgacctgcct ggtcaagggc ttctacccca gcgacattgc cgtggagtgg 1140
gagagcaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggatagcgac 1200
gggagcttct tcctgtacag caggctgacc gtggacaaaa gcaggtggca ggagggcaac 1260
gtgttcagct gctccgtgat gcacgaggcc ctccacaatc actacaccca gaagagcctg 1320
agcctgtccc tgggcaag                                               1338

<210> 9
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding PanELR IgG4(PE)N297A Heavy
      Chain

<400> 9
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaagtg 60
agctgcaagg ccagcggcta caccttcacc aactactgga tcgtgtgggt gaggcaggcc 120
cccggccagg gactggagtg gatgggcgac ctgtatagcg ggggaggcta caccttctac 180
agcgagaact tcaagggcag ggtgaccatg accagggaca ccagcaccag caccgtgtac 240
atggagctca gcagcctgag gagcgaggat acagccgtgt actattgcgc caggagcggc 300
tacgacagaa cctggttcgc ccactggggg cagggcaccc tcgtgactgt cagcagcgcc 360
agcaccaaag gcccctctgt gttccccctg gccccctgta gcaggagcac cagcgagtca 420
accgccgccc tgggctgcct ggtgaaagac tacttccctg agcccgtgac cgtgagctgg 480
aatagcggcg cactgaccag cggcgtgcac acctttcccg ccgtgctgca gtctagcggc 540
ctgtacagcc tgagctcagt ggtgaccgtg cccagcagca gcctgggcac caagacctac 600
acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagcgggt ggaaagcaag 660
tacggccccc cttgcccccc ctgccccgca cccgagttcg agggcggccc aagcgtgttc 720
ctgtttcccc ccaagcccaa ggacaccctg atgatcagca ggacccccga ggtgacttgc 780
gtggtggtgg acgtgtccca ggaggacccc gaggtgcagt tcaactggta cgtggacggc 840
gtggaagtgc acaacgccaa gaccaagccc agggaggagc agttcgccag cacctacagg 900
gtggtcagcg tcctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc 960
aaggtgagca acaagggcct gcccagcagc atcgagaaga ccatcagcaa ggccaaggga 1020
cagcccaggg agccccaggt gtacacactg ccccccagcc aggaagagat gaccaagaac 1080
caggtgagcc tgacctgcct ggtgaagggc ttctacccca gcgacattgc cgtcgagtgg 1140
gagagcaacg gccagcccga gaacaactac aagaccaccc cacctgtcct ggatagcgac 1200
ggcagcttct tcctgtacag caggctgacc gtggacaaga gcaggtggca ggagggcaac 1260
gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg 1320
agcctctccc tgggcaag                                               1338

<210> 10
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding PanELR IgG4(PE)N297S Heavy
      Chain

<400> 10
caggtccagc tggtgcagag cggcgccgaa gtgaagaaac ccggcgctag cgtgaaggtg 60
agctgcaagg ccagcggcta caccttcacc aactactgga tcgtgtgggt caggcaggcc 120
cccggccagg gcctggagtg gatgggcgac ctgtactcag gcggcggcta caccttctac 180
agcgagaact tcaagggcag ggtgaccatg accagggata ccagcaccag caccgtgtac 240
atggagctga gcagcctgag gagcgaggac actgccgtgt actattgcgc caggagcggc 300
tacgacagga cctggtttgc ccactgggga cagggcaccc tggtgaccgt cagctctgcc 360
tcaaccaagg gcccctcagt gttccctctg gccccctgta gcaggagcac cagcgagagc 420
accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg 480
aatagcgggg ctctgactag cggagtgcac accttccccg ccgtcctgca gtctagcggc 540
ctgtatagcc tgagcagcgt ggtcaccgtg ccaagcagca gcctgggcac caagacctac 600
acctgcaacg tggaccacaa gcccagcaac acaaaggtgg acaagagggt ggagtccaag 660
tacggccccc cctgccctcc ctgccccgca cccgagttcg agggcggccc ctccgtgttt 720
ctgttccccc ccaaacccaa ggacaccctg atgatcagca ggacccccga ggtgacttgc 780
gtggtggtgg acgtgagcca ggaggacccc gaggtgcagt tcaactggta cgtggacggc 840
gtggaggtgc acaacgccaa aaccaagccc agggaggagc agttcagcag cacctacagg 900
gtggtgagcg tgctgaccgt gctgcaccag gactggctca acggcaagga gtacaagtgc 960
aaggtgagca acaagggcct gcccagcagc atcgagaaga ccatcagcaa ggccaagggc 1020
cagcccagag agccacaggt gtacacactg ccccccagcc aggaggagat gaccaagaac 1080
caggtgagcc tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg 1140
gaaagcaacg gccagcccga gaacaactac aagaccaccc cccccgtgct cgatagcgac 1200
ggcagcttct tcctgtacag ccgcctgacc gtggacaaga gcaggtggca ggaaggcaac 1260
gtgttcagct gcagcgtgat gcacgaggcc ctccacaacc actacaccca gaagagcctg 1320
agcctgagcc tgggcaag                                               1338
