                         SEQUENCE LISTING

<110>  SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
 
<120>  HOMOGENOUS AND FULLY GLYCOSYLATED HUMAN ERYTHROPOIETIN

<130>  2003080-0521

<140>  PCT/US2013/038923
<141>  2013-04-30

<150>  61/640640
<151>  2012-04-30

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, homogenously glycosylated

<400>  1

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  2
<211>  165
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, homogenously glycosylated

<400>  2

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp 
                165 


<210>  3
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, homogenously glycosylated, modified


<220>
<221>  DISULFID
<222>  (7)..(161)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  DISULFID
<222>  (29)..(33)

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  glycosylation site

<400>  3

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  4
<211>  165
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, homogenously glycosylated, modified


<220>
<221>  DISULFID
<222>  (7)..(161)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  DISULFID
<222>  (29)..(33)

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  glycosylation site

<400>  4

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp 
                165 


<210>  5
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  chemical modification site

<400>  5

Cys Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser 
        35                  40                  45              


Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly 
65                  70                  75                  80  


Glu Ala Cys Arg Thr Gly Asp Arg 
                85              


<210>  6
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  chemical modification site

<400>  6

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln 
    50  


<210>  7
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  chemical modification site

<400>  7

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly 
            20                  25              


<210>  8
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  chemical modification site

<400>  8

Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg 
1               5                   10                  15      


Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu 
            20                  25                  30          


Ala Cys Arg Thr Gly Asp Arg 
        35                  


<210>  9
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  chemical modification site

<400>  9

Cys Ser Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
1               5                   10                  15      


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
            20                  25                  30          


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
        35                  40          


<210>  10
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (6)..(46)
<223>  chemical modification sites

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  chemical modification sites, pseudoproline dipeptide

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  chemical modification sites, pseudoproline dipeptide

<220>
<221>  MISC_FEATURE
<222>  (27)..(28)
<223>  chemical modification sites, pseudoproline dipeptide

<220>
<221>  MISC_FEATURE
<222>  (41)..(42)
<223>  chemical modification sites, pseudoproline dipeptide

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  chemical modification site

<400>  10

Cys Leu Leu Val Asp Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
        35                  40                  45      


<210>  11
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  chemical modification site

<400>  11

Cys Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
        35                  40                  45      


<210>  12
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  chemical modification site

<400>  12

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln 
    50  


<210>  13
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  chemical modification site

<400>  13

Cys Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys 
1               5                   10                  15      


Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val 
            20                  25                  30          


Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
        35                  40                  45              


Gln 
    


<210>  14
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  chemical modification site

<400>  14

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys 
            20                  25                  


<210>  15
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  chemical modification site

<400>  15

Cys Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Cys Ser 
        35                  40                  45              


Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly 
65                  70                  75                  80  


Glu Ala Cys Arg Thr Gly Asp Arg 
                85              


<210>  16
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  chemical modification site

<400>  16

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln Cys Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln 
    50                  55                  60                  


Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
                85                  90                  95      


Cys Ser Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
            100                 105                 110         


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
        115                 120                 125             


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    130                 135             


<210>  17
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  chemical modification site

<400>  17

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln 
    50                  55                  60                  


Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
                85                  90                  95      


Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
            100                 105                 110         


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
        115                 120                 125             


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    130                 135             


<210>  18
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<400>  18

Cys Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu 
1               5                   10                  15      


Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu 
            20                  25                  30          


Gln Leu His Val Asp Lys 
        35              


<210>  19
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  19

Gln Ala Leu Leu Val Asn 
1               5       


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  20

Arg Gly Gln Ala Leu Leu Val Asn 
1               5               


<210>  21
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  21

Val Leu Arg Gly Gln Ala Leu Leu Val Asn 
1               5                   10  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  22

Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn 
1               5                   10          


<210>  23
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  23

Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn 
1               5                   10                  


<210>  24
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  24

Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn 
1               5                   10                  15      


<210>  25
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  25

Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu 
1               5                   10                  15      


Val Asn 
        


<210>  26
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  26

Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala 
1               5                   10                  15      


Leu Leu Val Asn 
            20  


<210>  27
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  27

Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln 
1               5                   10                  15      


Ala Leu Leu Val Asn 
            20      


<210>  28
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  28

Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
1               5                   10                  15      


Gln Ala Leu Leu Val Asn 
            20          


<210>  29
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized

<400>  29

Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
1               5                   10                  15      


Gly Gln Ala Leu Leu Val Asn 
            20              


<210>  30
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  30

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly 
            20                  25              


<210>  31
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  chemical modification site

<400>  31

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln 
            20                  25                  30      


<210>  32
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  chemical modification site

<400>  32

Cys Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu 
1               5                   10                  15      


Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu 
            20                  25                  30          


Gln Leu His Val Asp Lys 
        35              


<210>  33
<211>  69
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  33

Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly 
1               5                   10                  15      


Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro 
            20                  25                  30          


Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr 
        35                  40                  45              


Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys 
    50                  55                  60                  


Arg Thr Gly Asp Arg 
65                  


<210>  34
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  chemical modification site

<400>  34

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Thr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly 
            20                  25              


<210>  35
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemically synthesized

<400>  35

Cys Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly 
1               5                   10                  15      


Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
            20                  25          


<210>  36
<211>  69
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  glycosylation site

<400>  36

Cys Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly 
1               5                   10                  15      


Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Cys Ser Ala Cys Pro 
            20                  25                  30          


Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr 
        35                  40                  45              


Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys 
    50                  55                  60                  


Arg Thr Gly Asp Arg 
65                  


<210>  37
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  chemical modification site

<400>  37

Cys Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu 
1               5                   10                  15      


Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu 
            20                  25                  30          


Gln Leu His Val Asp Lys Cys Val Ser Gly Leu Arg Ser Leu Thr Thr 
        35                  40                  45              


Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp 
    50                  55                  60                  


Ala Cys Ser Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg 
65                  70                  75                  80  


Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu 
                85                  90                  95      


Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
            100                 105         


<210>  38
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  chemical modification site

<400>  38

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Cys 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln 
    50                  55                  60                  


Leu His Val Asp Lys Cys Val Ser Gly Leu Arg Ser Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
                85                  90                  95      


Cys Ser Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
            100                 105                 110         


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
        115                 120                 125             


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    130                 135             


<210>  39
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  chemical modification site

<400>  39

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln 
    50                  55                  60                  


Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
                85                  90                  95      


Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
            100                 105                 110         


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
        115                 120                 125             


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    130                 135             


<210>  40
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized and homogenously glycosylated


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  glycosylation site

<400>  40

Ala Pro Pro Arg Leu Cys Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  41
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  41

Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
        35                  40                  45      


<210>  42
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  42

Ala Ser Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
1               5                   10                  15      


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
            20                  25                  30          


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
        35                  40          


<210>  43
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  43

Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu 
1               5                   10                  15      


Arg Gly Gln Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu 
            20                  25                  30          


Gln Leu His Val Asp Lys 
        35              


<210>  44
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  44

Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly 
1               5                   10                  15      


Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
            20                  25          


<210>  45
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  chemical modification site

<400>  45

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys 
            20                  25                  


<210>  46
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  46

Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys 
1               5                   10                  15      


Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val 
            20                  25                  30          


Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
        35                  40                  45              


Gln 
    


<210>  47
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  47

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln 
65                  70                  75              


<210>  48
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  48

Ala Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His 
1               5                   10                  15      


Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg 
            20                  25                  30          


Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser 
        35                  40                  45              


Ala Ala Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly 
65                  70                  75                  80  


Glu Ala Cys Arg Thr Gly Asp Arg 
                85              


<210>  49
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated

<400>  49

Cys Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys 
1               5                   10                  15      


Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val 
            20                  25                  30          


Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
        35                  40                  45              


Gln 
    


<210>  50
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  chemical modification site

<400>  50

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln Cys Leu Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln 
    50                  55                  60                  


Leu His Val Asp Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu 
65                  70                  75                  80  


Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala 
                85                  90                  95      


Cys Ser Ala Cys Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys 
            100                 105                 110         


Leu Phe Arg Val Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr 
        115                 120                 125             


Thr Gly Glu Ala Cys Arg Thr Gly Asp Arg 
    130                 135             


<210>  51
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  chemical modification site

<400>  51

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Cys Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Cys Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Cys Ser Ala Cys 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  52
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  chemical modification site

<400>  52

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  53
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  chemical modification site

<400>  53

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr 
1               5                   10          


<210>  54
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  chemical modification site

<400>  54

Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val 
1               5                   10                  15      


Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu 
            20                  25                  30          


Ala Val Leu Arg Gly Gln 
        35              


<210>  55
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  chemical modification site

<400>  55

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln 
    50  


<210>  56
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  chemical modification site

<400>  56

Cys Ala Glu His Cys Ser Leu Asn Glu Asp Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln 
    50  


<210>  57
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  chemical modification site

<400>  57

Cys Glu His Cys Ser Leu Asn Glu Asp Ile Thr Val Pro Asp Thr Lys 
1               5                   10                  15      


Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val 
            20                  25                  30          


Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly 
        35                  40                  45              


Gln 
    


<210>  58
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  chemical modification site

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  glycosylation site

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  chemical modification site

<400>  58

Cys Ala Glu His Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr 
1               5                   10                  15      


Lys Val Asn Phe Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala 
            20                  25                  30          


Val Glu Val Trp Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg 
        35                  40                  45              


Gly Gln 
    50  


<210>  59
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified

<400>  59

Cys Cys Val Ala Lys Ser Tyr Asn Phe Ser Gln Ala Met Gly Gly Phe 
1               5                   10                  15      


Lys Val Glu Asp Ala Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His 
            20                  25                  30          


Lys Ser 
        


<210>  60
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized, modified, glycosylated


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  glycosylation site

<400>  60

Cys Cys Val Ala Lys Ser Tyr Asn Phe Ser Gln Ala Met Gly Gly Phe 
1               5                   10                  15      


Lys Val Glu Asn Ala Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr His 
            20                  25                  30          


Lys Ser 
        


