                         SEQUENCE LISTING

<110>  DSM IP ASSETS B.V.
 
<120>  IMPROVED ENZYME VARIANTS

<130>  29196-WO-PCT

<150>  EP 12199277.0
<151>  2012-12-21

<150>  US 61/745063
<151>  2012-12-21

<150>  EP 12166673.9
<151>  2012-05-03

<150>  EP 12199178.0
<151>  2012-12-21

<150>  US 61/642095
<151>  2012-05-03

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1119
<212>  DNA
<213>  Bos taurus

<400>  1
ctcgagaaaa gagctgaaat caccagaatt ccattgtaca agggtaagtc tttgagaaag       60

gctttgaagg aacacggtct attggaagat ttcttacaaa agcaacagta cggtatttct      120

tccaagtact ccggtttcgg tgaagttgcc tccgtcccat tgaccaacta tctggactct      180

caatatttcg gtaagatcta cttgggtact ccacctcaag agttcaccgt ccttttcgac      240

actggttctt ctgatttctg ggttccatcc atctactgta agtccaatgc ttgtaagaac      300

catcaaagat ttgacccaag aaagtcttcc actttccaaa acttgggtaa gccattatcc      360

attcactatg gtactggttc catgcaaggt atcttgggtt acgacactgt tactgtttcc      420

aacattgttg acattcaaca aaccgtcggt ttgtccactc aagagcctgg cgatgttttc      480

acctacgctg aatttgatgg tattttgggt atggcttacc catctttggc ttctgaatac      540

tccatccctg tctttgacaa catgatgaac cgtcacttgg ttgctcaaga tttattctcc      600

gtttacatgg acagaaacgg tcaagaatcc atgttgactt taggtgccat tgatccatct      660

tactacactg gttctctaca ctgggttcca gttaccgtcc aacaatactg gcaattcacc      720

gttgactccg tcaccatctc cggtgttgtt gttgcttgtg aaggtggttg ccaagctatc      780

ttggacaccg gtacttccaa gttggtcggt ccatcttctg atatcttgaa cattcaacaa      840

gccattggtg ccactcaaaa ccagtacggt gaattcgata ttgactgtga caacttgtct      900

tacatgccaa ctgttgtctt tgaaatcaat ggtaagatgt acccattaac cccatctgct      960

tacacttctc aagaccaagg tttctgtact tctggtttcc aatctgaaaa ccattctcaa     1020

aaatggatct tgggtgatgt cttcatcaga gagtactact ccgtctttga ccgtgccaac     1080

aacttggttg gtttggccaa ggccatctaa gttaattaa                            1119


<210>  2
<211>  323
<212>  PRT
<213>  Bos taurus

<400>  2

Gly Glu Val Ala Ser Val Pro Leu Thr Asn Tyr Leu Asp Ser Gln Tyr 
1               5                   10                  15      


Phe Gly Lys Ile Tyr Leu Gly Thr Pro Pro Gln Glu Phe Thr Val Leu 
            20                  25                  30          


Phe Asp Thr Gly Ser Ser Asp Phe Trp Val Pro Ser Ile Tyr Cys Lys 
        35                  40                  45              


Ser Asn Ala Cys Lys Asn His Gln Arg Phe Asp Pro Arg Lys Ser Ser 
    50                  55                  60                  


Thr Phe Gln Asn Leu Gly Lys Pro Leu Ser Ile His Tyr Gly Thr Gly 
65                  70                  75                  80  


Ser Met Gln Gly Ile Leu Gly Tyr Asp Thr Val Thr Val Ser Asn Ile 
                85                  90                  95      


Val Asp Ile Gln Gln Thr Val Gly Leu Ser Thr Gln Glu Pro Gly Asp 
            100                 105                 110         


Val Phe Thr Tyr Ala Glu Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro 
        115                 120                 125             


Ser Leu Ala Ser Glu Tyr Ser Ile Pro Val Phe Asp Asn Met Met Asn 
    130                 135                 140                 


Arg His Leu Val Ala Gln Asp Leu Phe Ser Val Tyr Met Asp Arg Asn 
145                 150                 155                 160 


Gly Gln Glu Ser Met Leu Thr Leu Gly Ala Ile Asp Pro Ser Tyr Tyr 
                165                 170                 175     


Thr Gly Ser Leu His Trp Val Pro Val Thr Val Gln Gln Tyr Trp Gln 
            180                 185                 190         


Phe Thr Val Asp Ser Val Thr Ile Ser Gly Val Val Val Ala Cys Glu 
        195                 200                 205             


Gly Gly Cys Gln Ala Ile Leu Asp Thr Gly Thr Ser Lys Leu Val Gly 
    210                 215                 220                 


Pro Ser Ser Asp Ile Leu Asn Ile Gln Gln Ala Ile Gly Ala Thr Gln 
225                 230                 235                 240 


Asn Gln Tyr Gly Glu Phe Asp Ile Asp Cys Asp Asn Leu Ser Tyr Met 
                245                 250                 255     


Pro Thr Val Val Phe Glu Ile Asn Gly Lys Met Tyr Pro Leu Thr Pro 
            260                 265                 270         


Ser Ala Tyr Thr Ser Gln Asp Gln Gly Phe Cys Thr Ser Gly Phe Gln 
        275                 280                 285             


Ser Glu Asn His Ser Gln Lys Trp Ile Leu Gly Asp Val Phe Ile Arg 
    290                 295                 300                 


Glu Tyr Tyr Ser Val Phe Asp Arg Ala Asn Asn Leu Val Gly Leu Ala 
305                 310                 315                 320 


Lys Ala Ile 
            

<210>  3
<211>  1095
<212>  DNA
<213>  Camelus dromedarius

<400>  3
tctggtatca ccagaattcc attgcacaag ggtaagactt tgagaaaggc tttgaaggaa       60

agaggtttgt tggaagattt cttgcaaaga caacaatacg ctgtctcttc caaatactct      120

tctttgggta aggttgccag agaaccattg acttcttact tggactctca atacttcggt      180

aagatctaca ttggtactcc acctcaagaa ttcaccgttg tctttgacac tggttcttct      240

gatttatggg ttccatctat ctactgtaaa tccaatgtct gtaagaacca ccacagattt      300

gacccaagaa agtcttccac tttcagaaac ttgggtaagc cattatccat tcactacggt      360

actggttcca tggaaggttt cttgggttac gataccgtta ccgtttccaa catcgttgac      420

ccaaaccaaa ccgtcggtct atccactgaa caaccaggtg aagttttcac ctactctgaa      480

ttcgatggta tcttaggttt ggcttaccca tctttggcct ccgaatactc cgtcccagtt      540

ttcgacaaca tgatggacag acatttggtt gctcgtgatt tgttctccgt ctacatggac      600

agaaacggtc aaggttccat gttgactttg ggtgccattg acccatctta ctacactggt      660

tctttgcact gggttccagt caccttgcaa caatactggc aattcaccgt tgactctgtc      720

accatcaacg gtgttgctgt tgcttgtgtc ggtggttgtc aagctatttt ggataccggt      780

acttctgtct tgttcggtcc atcttctgat atcttgaaga tccaaatggc cattggtgct      840

actgaaaacc gttatggtga atttgatgtc aactgtggta acttgagatc catgccaacc      900

gttgttttcg aaatcaacgg tcgtgactac ccattgtctc catctgctta cacttccaag      960

gaccaaggtt tctgtacctc tggtttccaa ggtgacaaca actctgaatt atggatcttg     1020

ggtgatgttt tcatcagaga atactactcc gtcttcgaca gagctaacaa cagagtcggt     1080

ttagctaagg ctatt                                                      1095


<210>  4
<211>  323
<212>  PRT
<213>  Camelus dromedarius

<400>  4

Gly Lys Val Ala Arg Glu Pro Leu Thr Ser Tyr Leu Asp Ser Gln Tyr 
1               5                   10                  15      


Phe Gly Lys Ile Tyr Ile Gly Thr Pro Pro Gln Glu Phe Thr Val Val 
            20                  25                  30          


Phe Asp Thr Gly Ser Ser Asp Leu Trp Val Pro Ser Ile Tyr Cys Lys 
        35                  40                  45              


Ser Asn Val Cys Lys Asn His His Arg Phe Asp Pro Arg Lys Ser Ser 
    50                  55                  60                  


Thr Phe Arg Asn Leu Gly Lys Pro Leu Ser Ile His Tyr Gly Thr Gly 
65                  70                  75                  80  


Ser Met Glu Gly Phe Leu Gly Tyr Asp Thr Val Thr Val Ser Asn Ile 
                85                  90                  95      


Val Asp Pro Asn Gln Thr Val Gly Leu Ser Thr Glu Gln Pro Gly Glu 
            100                 105                 110         


Val Phe Thr Tyr Ser Glu Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro 
        115                 120                 125             


Ser Leu Ala Ser Glu Tyr Ser Val Pro Val Phe Asp Asn Met Met Asp 
    130                 135                 140                 


Arg His Leu Val Ala Arg Asp Leu Phe Ser Val Tyr Met Asp Arg Asn 
145                 150                 155                 160 


Gly Gln Gly Ser Met Leu Thr Leu Gly Ala Ile Asp Pro Ser Tyr Tyr 
                165                 170                 175     


Thr Gly Ser Leu His Trp Val Pro Val Thr Leu Gln Gln Tyr Trp Gln 
            180                 185                 190         


Phe Thr Val Asp Ser Val Thr Ile Asn Gly Val Ala Val Ala Cys Val 
        195                 200                 205             


Gly Gly Cys Gln Ala Ile Leu Asp Thr Gly Thr Ser Val Leu Phe Gly 
    210                 215                 220                 


Pro Ser Ser Asp Ile Leu Lys Ile Gln Met Ala Ile Gly Ala Thr Glu 
225                 230                 235                 240 


Asn Arg Tyr Gly Glu Phe Asp Val Asn Cys Gly Asn Leu Arg Ser Met 
                245                 250                 255     


Pro Thr Val Val Phe Glu Ile Asn Gly Arg Asp Tyr Pro Leu Ser Pro 
            260                 265                 270         


Ser Ala Tyr Thr Ser Lys Asp Gln Gly Phe Cys Thr Ser Gly Phe Gln 
        275                 280                 285             


Gly Asp Asn Asn Ser Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Arg 
    290                 295                 300                 


Glu Tyr Tyr Ser Val Phe Asp Arg Ala Asn Asn Arg Val Gly Leu Ala 
305                 310                 315                 320 


Lys Ala Ile 
            

<210>  5
<211>  199
<212>  PRT
<213>  Bos taurus

<400>  5

Arg Pro Lys His Pro Ile Lys His Gln Gly Leu Pro Gln Glu Val Leu 
1               5                   10                  15      


Asn Glu Asn Leu Leu Arg Phe Phe Val Ala Pro Phe Pro Glu Val Phe 
            20                  25                  30          


Gly Lys Glu Lys Val Asn Glu Leu Ser Lys Asp Ile Gly Ser Glu Ser 
        35                  40                  45              


Thr Glu Asp Gln Ala Met Glu Asp Ile Lys Gln Met Glu Ala Glu Ser 
    50                  55                  60                  


Ile Ser Ser Ser Glu Glu Ile Val Pro Asn Ser Val Glu Gln Lys His 
65                  70                  75                  80  


Ile Gln Lys Glu Asp Val Pro Ser Glu Arg Tyr Leu Gly Tyr Leu Glu 
                85                  90                  95      


Gln Leu Leu Arg Leu Lys Lys Tyr Lys Val Pro Gln Leu Glu Ile Val 
            100                 105                 110         


Pro Asn Ser Ala Glu Glu Arg Leu His Ser Met Lys Glu Gly Ile His 
        115                 120                 125             


Ala Gln Gln Lys Glu Pro Met Ile Gly Val Asn Gln Glu Leu Ala Tyr 
    130                 135                 140                 


Phe Tyr Pro Glu Leu Phe Arg Gln Phe Tyr Gln Leu Asp Ala Tyr Pro 
145                 150                 155                 160 


Ser Gly Ala Trp Tyr Tyr Val Pro Leu Gly Thr Gln Tyr Thr Asp Ala 
                165                 170                 175     


Pro Ser Phe Ser Asp Ile Pro Asn Pro Ile Gly Ser Glu Asn Ser Glu 
            180                 185                 190         


Lys Thr Thr Met Pro Leu Trp 
        195                 


