                         SEQUENCE LISTING

<110>  Intervet International BV
       Morsey, Mohamad A.
       Mattson, Jeanine D.
       Gorman, Daniel M.
       de Waal Malefyt, Rene
       Presta, Leonard G.
 
<120>  Canine Thymic Stromal Lymphopoietin Protein Fusion Protein With 
       The Fc Region of IgG

<130>  23231-WO-PCT

<150>  US 61/642,563
<151>  2012-05-04

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  468
<212>  DNA
<213>  Canis familiaris

<400>  1
atggtgcctg atgccctgct gagcgtgctg agcgtgttct ttaggaagat cttcgtcttg       60

cagctggtag ggctggtgct aacctacaat ttcattgact gtgactttga gaagattaga      120

tggaagtatc aggaagtcat ttaccaagcc ctggagaaat acatggatgg gaccaggagc      180

acggagttca gccaccccgt gtactgcgcg aacccgcccg actgcctggc caggatcgag      240

cggctcaccc tgcaccgcat ccgcggctgc gcgtcgggcg cccgggaggc cttcgccgag      300

gggacggtcg ccgcgctcgc cgccgagtgc ccgggctacg ccgcagcgcc gataaataat      360

acccaggcaa agaagaaaag aaaaaaaaga ggagtcacaa caaataaatg ccgggaacaa      420

gtcgcacact taatagggct gtggcgtcgt ttcagtcgca tttcatag                   468


<210>  2
<211>  155
<212>  PRT
<213>  Canis familiaris

<400>  2

Met Val Pro Asp Ala Leu Leu Ser Val Leu Ser Val Phe Phe Arg Lys 
1               5                   10                  15      


Ile Phe Val Leu Gln Leu Val Gly Leu Val Leu Thr Tyr Asn Phe Ile 
            20                  25                  30          


Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr 
        35                  40                  45              


Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser 
    50                  55                  60                  


His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu 
65                  70                  75                  80  


Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu 
                85                  90                  95      


Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly 
            100                 105                 110         


Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys Lys Lys Arg Lys 
        115                 120                 125             


Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu Gln Val Ala His Leu 
    130                 135                 140                 


Ile Gly Leu Trp Arg Arg Phe Ser Arg Ile Ser 
145                 150                 155 


<210>  3
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encodes a fusion protein of human, canis familiaris, and murine 
       sequence.

<400>  3
atgaaggtgt ccgccgctct gctgtgcctg ctgctgatcg ccgccacatt catcccacag       60

ggcttagcct acaacttcat cgactgcgac ttcgagaaga tccggtggaa gtaccaggaa      120

gtgatctacc aggccctgga aaagtacatg gacggcaccc ggtccaccga gttcagccac      180

cccgtgtact gcgccaaccc ccccgactgc ctggccagaa tcgagcggct gaccctgcac      240

agaatcagag gctgcgccag cggagccaga gaggcctttg ccgaaggaac agtggccgcc      300

ctggccgccg aatgtcctgg ctacgccgct gcccccatca acaacaccca ggccaagaag      360

aagcggaaga aacggggcgt gaccaccaac aagtgccggg aacaggtggc ccatctgatc      420

ggcctgtggc ggcggttcag ccggatcagc gggcccacaa tcaagccctg tcctccatgc      480

aaatgcccag cacctaacct cttgggtgga ccatccgtct tcatcttccc tccaaagatc      540

aaggatgtac tcatgatctc cctgagcccc atggtcacat gtgtggtggt ggatgtgagc      600

gaggatgacc cagatgtcca gatcagctgg ttcgtgaaca acgtggaagt actcacagct      660

cagacacaaa cccatagaga ggattacaac agtactctcc gggtggtcag tgccctcccc      720

atccagcacc aggactggat gagtggcaag gagttcaaat gcaaggtcaa caacaaagcc      780

ctcccagcgc ccatcgagag aaccatctca aaacccaaag ggtcagtaag agctccacag      840

gtatatgtct tgcctccacc agaagaagag atgactaaga aacaggtcac tctgacctgc      900

atggtcacag acttcatgcc tgaagacatt tacgtggagt ggaccaacaa cgggaaaaca      960

gagctaaact acaagaacac tgaaccagtc ctggactctg atggttctta cttcatgtac     1020

agcaagctga gagtggaaaa gaagaactgg gtggaaagaa atagctactc ctgctcagtg     1080

gtccacgagg gtctgcacaa tcaccacacg actaagagct tctcccggac tccgggtaaa     1140

tga                                                                   1143


<210>  4
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of human, canis familiaris, and murine sequence.

<400>  4

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Tyr Asn Phe Ile Asp Cys Asp Phe Glu 
            20                  25                  30          


Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys 
        35                  40                  45              


Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys 
    50                  55                  60                  


Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His 
65                  70                  75                  80  


Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly 
                85                  90                  95      


Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr Ala Ala Ala Pro 
            100                 105                 110         


Ile Asn Asn Thr Gln Ala Lys Lys Lys Arg Lys Lys Arg Gly Val Thr 
        115                 120                 125             


Thr Asn Lys Cys Arg Glu Gln Val Ala His Leu Ile Gly Leu Trp Arg 
    130                 135                 140                 


Arg Phe Ser Arg Ile Ser Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
145                 150                 155                 160 


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
                165                 170                 175     


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val 
            180                 185                 190         


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
        195                 200                 205             


Ser Trp Phe Val Asn Asn Val Glu Val Leu Thr Ala Gln Thr Gln Thr 
    210                 215                 220                 


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
225                 230                 235                 240 


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
                245                 250                 255     


Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
            260                 265                 270         


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
        275                 280                 285             


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
    290                 295                 300                 


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
305                 310                 315                 320 


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
                325                 330                 335     


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
            340                 345                 350         


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
        355                 360                 365             


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    370                 375                 380 


<210>  5
<211>  381
<212>  DNA
<213>  Canis familiaris

<400>  5
tacaacttca tcgactgcga cttcgagaag atccggtgga agtaccagga agtgatctac       60

caggccctgg aaaagtacat ggacggcacc cggtccaccg agttcagcca ccccgtgtac      120

tgcgccaacc cccccgactg cctggccaga atcgagcggc tgaccctgca cagaatcaga      180

ggctgcgcca gcggagccag agaggccttt gccgaaggaa cagtggccgc cctggccgcc      240

gaatgtcctg gctacgccgc tgcccccatc aacaacaccc aggccaagaa gaagcggaag      300

aaacggggcg tgaccaccaa caagtgccgg gaacaggtgg cccatctgat cggcctgtgg      360

cggcggttca gccggatcag c                                                381


<210>  6
<211>  127
<212>  PRT
<213>  Canis familiaris

<400>  6

Tyr Asn Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln 
1               5                   10                  15      


Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser 
            20                  25                  30          


Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu 
        35                  40                  45              


Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser 
    50                  55                  60                  


Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala 
65                  70                  75                  80  


Glu Cys Pro Gly Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys 
                85                  90                  95      


Lys Lys Arg Lys Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu Gln 
            100                 105                 110         


Val Ala His Leu Ile Gly Leu Trp Arg Arg Phe Ser Arg Ile Ser 
        115                 120                 125         


<210>  7
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encodes a fusion protein with canis familiariis and murine 
       sequence

<400>  7
tacaacttca tcgactgcga cttcgagaag atccggtgga agtaccagga agtgatctac       60

caggccctgg aaaagtacat ggacggcacc cggtccaccg agttcagcca ccccgtgtac      120

tgcgccaacc cccccgactg cctggccaga atcgagcggc tgaccctgca cagaatcaga      180

ggctgcgcca gcggagccag agaggccttt gccgaaggaa cagtggccgc cctggccgcc      240

gaatgtcctg gctacgccgc tgcccccatc aacaacaccc aggccaagaa gaagcggaag      300

aaacggggcg tgaccaccaa caagtgccgg gaacaggtgg cccatctgat cggcctgtgg      360

cggcggttca gccggatcag cgggcccaca atcaagccct gtcctccatg caaatgccca      420

gcacctaacc tcttgggtgg accatccgtc ttcatcttcc ctccaaagat caaggatgta      480

ctcatgatct ccctgagccc catggtcaca tgtgtggtgg tggatgtgag cgaggatgac      540

ccagatgtcc agatcagctg gttcgtgaac aacgtggaag tactcacagc tcagacacaa      600

acccatagag aggattacaa cagtactctc cgggtggtca gtgccctccc catccagcac      660

caggactgga tgagtggcaa ggagttcaaa tgcaaggtca acaacaaagc cctcccagcg      720

cccatcgaga gaaccatctc aaaacccaaa gggtcagtaa gagctccaca ggtatatgtc      780

ttgcctccac cagaagaaga gatgactaag aaacaggtca ctctgacctg catggtcaca      840

gacttcatgc ctgaagacat ttacgtggag tggaccaaca acgggaaaac agagctaaac      900

tacaagaaca ctgaaccagt cctggactct gatggttctt acttcatgta cagcaagctg      960

agagtggaaa agaagaactg ggtggaaaga aatagctact cctgctcagt ggtccacgag     1020

ggtctgcaca atcaccacac gactaagagc ttctcccgga ctccgggtaa atga           1074


<210>  8
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein with canis familiaris and murine sequence

<400>  8

Tyr Asn Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln 
1               5                   10                  15      


Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser 
            20                  25                  30          


Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu 
        35                  40                  45              


Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser 
    50                  55                  60                  


Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala 
65                  70                  75                  80  


Glu Cys Pro Gly Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys 
                85                  90                  95      


Lys Lys Arg Lys Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu Gln 
            100                 105                 110         


Val Ala His Leu Ile Gly Leu Trp Arg Arg Phe Ser Arg Ile Ser Gly 
        115                 120                 125             


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
145                 150                 155                 160 


Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
            180                 185                 190         


Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
        195                 200                 205             


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
    210                 215                 220                 


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
                245                 250                 255     


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
            260                 265                 270         


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
        275                 280                 285             


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
    290                 295                 300                 


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
305                 310                 315                 320 


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
                325                 330                 335     


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
            340                 345                 350         


Arg Thr Pro Gly Lys 
        355         


<210>  9
<211>  693
<212>  DNA
<213>  Mus musculus

<400>  9
gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga       60

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      120

atggtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      180

ttcgtgaaca acgtggaagt actcacagct cagacacaaa cccatagaga ggattacaac      240

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag      300

gagttcaaat gcaaggtcaa caacaaagcc ctcccagcgc ccatcgagag aaccatctca      360

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag      420

atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt      480

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc      540

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg      600

gtggaaagaa atagctactc ctgctcagtg gtccacgagg gtctgcacaa tcaccacacg      660

actaagagct tctcccggac tccgggtaaa tga                                   693


<210>  10
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            20                  25                  30          


Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    50                  55                  60                  


Val Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
65                  70                  75                  80  


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                85                  90                  95      


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        115                 120                 125             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    130                 135                 140                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
145                 150                 155                 160 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                165                 170                 175     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            180                 185                 190         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        195                 200                 205             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    210                 215                 220                 


Ser Arg Thr Pro Gly Lys 
225                 230 


<210>  11
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  11

Tyr Asn Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  12

Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  13

Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  14

Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  15

Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  16

Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  17

Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  18

Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  19

Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  20

Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  21

Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  22

Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  23

Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  24

Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  25

Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  26

Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  27

Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  28

Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  29

His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  30

Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  31

Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  32

Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  33

Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  34

Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  35

Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  36

Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  37

Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  38

Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  39

His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  40

Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  41

Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  42

Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  43

Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  44

Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  45

Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  46

Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  47

Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr Ala Ala 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  48

Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr Ala Ala Ala Pro 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  49

Ala Leu Ala Ala Glu Cys Pro Gly Tyr Ala Ala Ala Pro Ile Asn 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  50

Ala Ala Glu Cys Pro Gly Tyr Ala Ala Ala Pro Ile Asn Asn Thr 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  51

Glu Cys Pro Gly Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  52

Pro Gly Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys Lys 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  53

Tyr Ala Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys Lys Lys Arg 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  54

Ala Ala Pro Ile Asn Asn Thr Gln Ala Lys Lys Lys Arg Lys Lys 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  55

Pro Ile Asn Asn Thr Gln Ala Lys Lys Lys Arg Lys Lys Arg Gly 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  56

Asn Asn Thr Gln Ala Lys Lys Lys Arg Lys Lys Arg Gly Val Thr 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  57

Thr Gln Ala Lys Lys Lys Arg Lys Lys Arg Gly Val Thr Thr Asn 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  58

Ala Lys Lys Lys Arg Lys Lys Arg Gly Val Thr Thr Asn Lys Cys 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  59

Lys Lys Arg Lys Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  60

Arg Lys Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu Gln Val 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  61

Lys Arg Gly Val Thr Thr Asn Lys Cys Arg Glu Gln Val Ala His 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  62

Gly Val Thr Thr Asn Lys Cys Arg Glu Gln Val Ala His Leu Ile 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  63

Thr Thr Asn Lys Cys Arg Glu Gln Val Ala His Leu Ile Gly Leu 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  64

Asn Lys Cys Arg Glu Gln Val Ala His Leu Ile Gly Leu Trp Arg 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  65

Cys Arg Glu Gln Val Ala His Leu Ile Gly Leu Trp Arg Arg Phe 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  66

Glu Gln Val Ala His Leu Ile Gly Leu Trp Arg Arg Phe Ser Arg 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  67

Val Ala His Leu Ile Gly Leu Trp Arg Arg Phe Ser Arg Ile Ser 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  68

Tyr Asn Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  69

Phe Ile Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  70

Asp Cys Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  71

Asp Phe Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  72

Glu Lys Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  73

Ile Arg Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  74

Trp Lys Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  75

Tyr Gln Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  76

Glu Val Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  77

Ile Tyr Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  78

Gln Ala Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  79

Leu Glu Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  80

Lys Tyr Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  81

Met Asp Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  82

Gly Thr Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  83

Arg Ser Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  84

Thr Glu Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  85

Phe Ser His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  86

His Pro Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  87

Val Tyr Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  88

Cys Ala Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  89

Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  90

Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  91

Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  92

Ala Arg Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  93

Ile Glu Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  94

Arg Leu Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  95

Thr Leu His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  96

His Arg Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  97

Ile Arg Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  98

Gly Cys Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  99

Ala Ser Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  100

Gly Ala Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  101

Arg Glu Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  102

Ala Phe Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  103

Ala Glu Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  104

Gly Thr Val Ala Ala Leu Ala Ala Glu Cys Pro Gly Tyr Ala Ala 
1               5                   10                  15  


<210>  105
<211>  22
<212>  PRT
<213>  Canis familiaris

<400>  105

Asn Pro Pro Asp Cys Leu Ala Arg Ile Glu Arg Leu Thr Leu His Arg 
1               5                   10                  15      


Ile Arg Gly Cys Ala Ser 
            20          


<210>  106
<211>  9
<212>  PRT
<213>  Canis familiaris

<400>  106

Arg Ile Glu Arg Leu Thr Leu His Arg 
1               5                   


<210>  107
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  107
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaa                                696


<210>  108
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  108

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  109
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  109
gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc       60

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      120

ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag      180

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      240

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg      300

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga      360

accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca      420

gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct      480

gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact      540

gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag      600

aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat      660

caccacacga ctaagagctt ctcccggact ccgggtaaa                             699


<210>  110
<211>  233
<212>  PRT
<213>  Mus musculus

<400>  110

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  111
<211>  1122
<212>  DNA
<213>  Canis familiaris

<400>  111
atgagaaccg tacttttgcc ttgggcttca gcggcagtgt ttcttttggt tacagtgact       60

gtctcagggg acgaggcatt ggagggggta ctccagcttc aaatgattaa cttcaatttt      120

gaggcggtcc aggtgacctg gaatgcctcc cagtacagcg gcacaaatct cacttttctg      180

tacaaattga cctcagacga gacagatagc cagtgctcca actacattct ccagcagtca      240

aggaccgctg ggtgtctcct cgaggctaag gaggacgaga ttctgtgctt tagcatctgg      300

aacgggaccc ggctgctgtt gaataaatgc cagtggatct ccgcttacct gaagccatca      360

tcccctaagg acttgaattt tcagtggcat caagaggcca tcactgtgac gtgcagcgat      420

ctgccttata agagactcct ttacgagatt caatataagt ctatgtttga tactgagtgg      480

cagtccaagg agggcgagac ttgtaatgtg accactgatg gtttggatgc cgagaaatgt      540

tatttcttta gagctagagt caagactatg gaaagcagct acgggcctga cacctatcca      600

agtgactgga gcgaggtaat tcatcagcaa aagggcgagc tgagagattc ttgccaagaa      660

aagaagctgt ttcctaaatt cattcttgtg tccgggatgg tcgcattgct caccgtatcc      720

ctgctgcttc tttccttgtg gaaagttaga agggtcaaga aactcctgat gccttctgtc      780

cctgacccca agttcacttt tcctgggctc ttcgaaagcc atcagggaaa cttccaggaa      840

tggatcaagg atactcagaa cgtggttccc ctcaacaaaa tggagggcgc cgagcacgat      900

tgtgggccag aggaggctct cattgtgcac ctggcaaccg ctgaagccga gatgcccata      960

ctgactacag gtccgagctg ccctcagaca gaggaagaag aggcttctgg cgatcccagt     1020

cagctccccg gccagcctct ccagggcgga ggcggcgggg aacgagtgag tctgggagga     1080

ttcacttttg tgatgtccga taactcatac gtgatgttgt aa                        1122


<210>  112
<211>  373
<212>  PRT
<213>  Canis familiaris

<400>  112

Met Arg Thr Val Leu Leu Pro Trp Ala Ser Ala Ala Val Phe Leu Leu 
1               5                   10                  15      


Val Thr Val Thr Val Ser Gly Asp Glu Ala Leu Glu Gly Val Leu Gln 
            20                  25                  30          


Leu Gln Met Ile Asn Phe Asn Phe Glu Ala Val Gln Val Thr Trp Asn 
        35                  40                  45              


Ala Ser Gln Tyr Ser Gly Thr Asn Leu Thr Phe Leu Tyr Lys Leu Thr 
    50                  55                  60                  


Ser Asp Glu Thr Asp Ser Gln Cys Ser Asn Tyr Ile Leu Gln Gln Ser 
65                  70                  75                  80  


Arg Thr Ala Gly Cys Leu Leu Glu Ala Lys Glu Asp Glu Ile Leu Cys 
                85                  90                  95      


Phe Ser Ile Trp Asn Gly Thr Arg Leu Leu Leu Asn Lys Cys Gln Trp 
            100                 105                 110         


Ile Ser Ala Tyr Leu Lys Pro Ser Ser Pro Lys Asp Leu Asn Phe Gln 
        115                 120                 125             


Trp His Gln Glu Ala Ile Thr Val Thr Cys Ser Asp Leu Pro Tyr Lys 
    130                 135                 140                 


Arg Leu Leu Tyr Glu Ile Gln Tyr Lys Ser Met Phe Asp Thr Glu Trp 
145                 150                 155                 160 


Gln Ser Lys Glu Gly Glu Thr Cys Asn Val Thr Thr Asp Gly Leu Asp 
                165                 170                 175     


Ala Glu Lys Cys Tyr Phe Phe Arg Ala Arg Val Lys Thr Met Glu Ser 
            180                 185                 190         


Ser Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Ile His 
        195                 200                 205             


Gln Gln Lys Gly Glu Leu Arg Asp Ser Cys Gln Glu Lys Lys Leu Phe 
    210                 215                 220                 


Pro Lys Phe Ile Leu Val Ser Gly Met Val Ala Leu Leu Thr Val Ser 
225                 230                 235                 240 


Leu Leu Leu Leu Ser Leu Trp Lys Val Arg Arg Val Lys Lys Leu Leu 
                245                 250                 255     


Met Pro Ser Val Pro Asp Pro Lys Phe Thr Phe Pro Gly Leu Phe Glu 
            260                 265                 270         


Ser His Gln Gly Asn Phe Gln Glu Trp Ile Lys Asp Thr Gln Asn Val 
        275                 280                 285             


Val Pro Leu Asn Lys Met Glu Gly Ala Glu His Asp Cys Gly Pro Glu 
    290                 295                 300                 


Glu Ala Leu Ile Val His Leu Ala Thr Ala Glu Ala Glu Met Pro Ile 
305                 310                 315                 320 


Leu Thr Thr Gly Pro Ser Cys Pro Gln Thr Glu Glu Glu Glu Ala Ser 
                325                 330                 335     


Gly Asp Pro Ser Gln Leu Pro Gly Gln Pro Leu Gln Gly Gly Gly Gly 
            340                 345                 350         


Gly Glu Arg Val Ser Leu Gly Gly Phe Thr Phe Val Met Ser Asp Asn 
        355                 360                 365             


Ser Tyr Val Met Leu 
    370             


<210>  113
<211>  1053
<212>  DNA
<213>  Canis familiaris

<400>  113
gacgaggcat tggagggggt actccagctt caaatgatta acttcaattt tgaggcggtc       60

caggtgacct ggaatgcctc ccagtacagc ggcacaaatc tcacttttct gtacaaattg      120

acctcagacg agacagatag ccagtgctcc aactacattc tccagcagtc aaggaccgct      180

gggtgtctcc tcgaggctaa ggaggacgag attctgtgct ttagcatctg gaacgggacc      240

cggctgctgt tgaataaatg ccagtggatc tccgcttacc tgaagccatc atcccctaag      300

gacttgaatt ttcagtggca tcaagaggcc atcactgtga cgtgcagcga tctgccttat      360

aagagactcc tttacgagat tcaatataag tctatgtttg atactgagtg gcagtccaag      420

gagggcgaga cttgtaatgt gaccactgat ggtttggatg ccgagaaatg ttatttcttt      480

agagctagag tcaagactat ggaaagcagc tacgggcctg acacctatcc aagtgactgg      540

agcgaggtaa ttcatcagca aaagggcgag ctgagagatt cttgccaaga aaagaagctg      600

tttcctaaat tcattcttgt gtccgggatg gtcgcattgc tcaccgtatc cctgctgctt      660

ctttccttgt ggaaagttag aagggtcaag aaactcctga tgccttctgt ccctgacccc      720

aagttcactt ttcctgggct cttcgaaagc catcagggaa acttccagga atggatcaag      780

gatactcaga acgtggttcc cctcaacaaa atggagggcg ccgagcacga ttgtgggcca      840

gaggaggctc tcattgtgca cctggcaacc gctgaagccg agatgcccat actgactaca      900

ggtccgagct gccctcagac agaggaagaa gaggcttctg gcgatcccag tcagctcccc      960

ggccagcctc tccagggcgg aggcggcggg gaacgagtga gtctgggagg attcactttt     1020

gtgatgtccg ataactcata cgtgatgttg taa                                  1053


<210>  114
<211>  350
<212>  PRT
<213>  Canis familiaris

<400>  114

Asp Glu Ala Leu Glu Gly Val Leu Gln Leu Gln Met Ile Asn Phe Asn 
1               5                   10                  15      


Phe Glu Ala Val Gln Val Thr Trp Asn Ala Ser Gln Tyr Ser Gly Thr 
            20                  25                  30          


Asn Leu Thr Phe Leu Tyr Lys Leu Thr Ser Asp Glu Thr Asp Ser Gln 
        35                  40                  45              


Cys Ser Asn Tyr Ile Leu Gln Gln Ser Arg Thr Ala Gly Cys Leu Leu 
    50                  55                  60                  


Glu Ala Lys Glu Asp Glu Ile Leu Cys Phe Ser Ile Trp Asn Gly Thr 
65                  70                  75                  80  


Arg Leu Leu Leu Asn Lys Cys Gln Trp Ile Ser Ala Tyr Leu Lys Pro 
                85                  90                  95      


Ser Ser Pro Lys Asp Leu Asn Phe Gln Trp His Gln Glu Ala Ile Thr 
            100                 105                 110         


Val Thr Cys Ser Asp Leu Pro Tyr Lys Arg Leu Leu Tyr Glu Ile Gln 
        115                 120                 125             


Tyr Lys Ser Met Phe Asp Thr Glu Trp Gln Ser Lys Glu Gly Glu Thr 
    130                 135                 140                 


Cys Asn Val Thr Thr Asp Gly Leu Asp Ala Glu Lys Cys Tyr Phe Phe 
145                 150                 155                 160 


Arg Ala Arg Val Lys Thr Met Glu Ser Ser Tyr Gly Pro Asp Thr Tyr 
                165                 170                 175     


Pro Ser Asp Trp Ser Glu Val Ile His Gln Gln Lys Gly Glu Leu Arg 
            180                 185                 190         


Asp Ser Cys Gln Glu Lys Lys Leu Phe Pro Lys Phe Ile Leu Val Ser 
        195                 200                 205             


Gly Met Val Ala Leu Leu Thr Val Ser Leu Leu Leu Leu Ser Leu Trp 
    210                 215                 220                 


Lys Val Arg Arg Val Lys Lys Leu Leu Met Pro Ser Val Pro Asp Pro 
225                 230                 235                 240 


Lys Phe Thr Phe Pro Gly Leu Phe Glu Ser His Gln Gly Asn Phe Gln 
                245                 250                 255     


Glu Trp Ile Lys Asp Thr Gln Asn Val Val Pro Leu Asn Lys Met Glu 
            260                 265                 270         


Gly Ala Glu His Asp Cys Gly Pro Glu Glu Ala Leu Ile Val His Leu 
        275                 280                 285             


Ala Thr Ala Glu Ala Glu Met Pro Ile Leu Thr Thr Gly Pro Ser Cys 
    290                 295                 300                 


Pro Gln Thr Glu Glu Glu Glu Ala Ser Gly Asp Pro Ser Gln Leu Pro 
305                 310                 315                 320 


Gly Gln Pro Leu Gln Gly Gly Gly Gly Gly Glu Arg Val Ser Leu Gly 
                325                 330                 335     


Gly Phe Thr Phe Val Met Ser Asp Asn Ser Tyr Val Met Leu 
            340                 345                 350 


<210>  115
<211>  1371
<212>  DNA
<213>  Canis familiaris

<400>  115
atgacgatcc tgggaacagc gtttggaatg gtattttacc ttctgcaagc tgtgagcggg       60

gagagcggat acgcccagaa cggagacttt gaggacgccg agttggacga ctactctttc      120

tcatgctaca gccaactgga ggtggacgga acccagcact tgcttacctg cacattcgat      180

gacccagaca taaattcaac caacctggaa tttgaaatct gtggcgctct tctgaacgtc      240

aagtgcctca cattcaacaa gttgcaggag atgtacttta tcaaaacaaa gaagtttctg      300

cttatcggcg actccgaaat ctacgtgaaa ctggagggga aaaacattac tagcaagaag      360

ctgaatatcg tacggatagt gaaacccgag gccccctttg acgtcagggt gatctatagg      420

gaaggagcta atgacttcct ggtcactttt aacacctctc atctccagaa gaaatatgta      480

aaggaactcg tgcatgaggt cgcataccga caagaaaaga atgaaaatga ttggacatgt      540

gtgaatctga gtagtaccaa gttgacactg ctgcaaagaa agctccagcc cgacgcgatg      600

tatgagatta aagtgcggtc catccctaat gcgaactact tccagggctt ttggagcgag      660

tggtcaccct cttttcattt caggactcca gagattaccg ggcgaatgga cccggtgttg      720

cttacaatct ctattttgtc cttcttttct gtgacgctga tggtaatcct ggcctttgca      780

ctctggaaga agaggataaa gcctatggtt tggccttctc tcccggacca taaaaagacc      840

ctggagcaac tttgtaaaaa gccaaagaaa aacctcaatg tgtcctttaa ccccgagtca      900

ttcttggact gccagataca caaggtcgat gggattcagg ccagggacga agcagagtca      960

tttctccagg acacaagtcc ccagttggat gaaagcgaga agcagcggct gggtgggggt     1020

ctgcaaggtc ctacttggcc cccagagcac gcggtcatca ctccaaaaac cttccgcggc     1080

gacccacctt ttggctgctt ggctgggaat gtaagcatgt tcgaggccct ggccttgcca     1140

tcatcccgca gcgctgattg cagggaaggc gggaaaaacg gaccccacgt gtaccaggga     1200

cttttgctcg gacccggaac gacctctgga acagtgccta ccccgttccc atttcagtca     1260

gggattctca ccccaaatcc tgccgcgcag ggccagccag ttctgacgtc tttggggagt     1320

tcacaggagg aggcttacgt gacaatgtcc agcttttatc agaaccagta a              1371


<210>  116
<211>  456
<212>  PRT
<213>  Canis familiaris

<400>  116

Met Thr Ile Leu Gly Thr Ala Phe Gly Met Val Phe Tyr Leu Leu Gln 
1               5                   10                  15      


Ala Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Phe Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asp Gly Thr Gln His Leu Leu Thr Cys Thr Phe Asp Asp Pro Asp Ile 
    50                  55                  60                  


Asn Ser Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Leu Asn Val 
65                  70                  75                  80  


Lys Cys Leu Thr Phe Asn Lys Leu Gln Glu Met Tyr Phe Ile Lys Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Asp Ser Glu Ile Tyr Val Lys Leu Glu 
            100                 105                 110         


Gly Lys Asn Ile Thr Ser Lys Lys Leu Asn Ile Val Arg Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Val Arg Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Leu Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Glu Leu Val His Glu Val Ala Tyr Arg Gln Glu Lys Asn Glu Asn 
                165                 170                 175     


Asp Trp Thr Cys Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Asp Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asn Ala Asn Tyr Phe Gln Gly Phe Trp Ser Glu Trp Ser Pro Ser 
    210                 215                 220                 


Phe His Phe Arg Thr Pro Glu Ile Thr Gly Arg Met Asp Pro Val Leu 
225                 230                 235                 240 


Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Thr Leu Met Val Ile 
                245                 250                 255     


Leu Ala Phe Ala Leu Trp Lys Lys Arg Ile Lys Pro Met Val Trp Pro 
            260                 265                 270         


Ser Leu Pro Asp His Lys Lys Thr Leu Glu Gln Leu Cys Lys Lys Pro 
        275                 280                 285             


Lys Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys 
    290                 295                 300                 


Gln Ile His Lys Val Asp Gly Ile Gln Ala Arg Asp Glu Ala Glu Ser 
305                 310                 315                 320 


Phe Leu Gln Asp Thr Ser Pro Gln Leu Asp Glu Ser Glu Lys Gln Arg 
                325                 330                 335     


Leu Gly Gly Gly Leu Gln Gly Pro Thr Trp Pro Pro Glu His Ala Val 
            340                 345                 350         


Ile Thr Pro Lys Thr Phe Arg Gly Asp Pro Pro Phe Gly Cys Leu Ala 
        355                 360                 365             


Gly Asn Val Ser Met Phe Glu Ala Leu Ala Leu Pro Ser Ser Arg Ser 
    370                 375                 380                 


Ala Asp Cys Arg Glu Gly Gly Lys Asn Gly Pro His Val Tyr Gln Gly 
385                 390                 395                 400 


Leu Leu Leu Gly Pro Gly Thr Thr Ser Gly Thr Val Pro Thr Pro Phe 
                405                 410                 415     


Pro Phe Gln Ser Gly Ile Leu Thr Pro Asn Pro Ala Ala Gln Gly Gln 
            420                 425                 430         


Pro Val Leu Thr Ser Leu Gly Ser Ser Gln Glu Glu Ala Tyr Val Thr 
        435                 440                 445             


Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455     


<210>  117
<211>  1311
<212>  DNA
<213>  Canis familiaris

<400>  117
gagagcggat acgcccagaa cggagacttt gaggacgccg agttggacga ctactctttc       60

tcatgctaca gccaactgga ggtggacgga acccagcact tgcttacctg cacattcgat      120

gacccagaca taaattcaac caacctggaa tttgaaatct gtggcgctct tctgaacgtc      180

aagtgcctca cattcaacaa gttgcaggag atgtacttta tcaaaacaaa gaagtttctg      240

cttatcggcg actccgaaat ctacgtgaaa ctggagggga aaaacattac tagcaagaag      300

ctgaatatcg tacggatagt gaaacccgag gccccctttg acgtcagggt gatctatagg      360

gaaggagcta atgacttcct ggtcactttt aacacctctc atctccagaa gaaatatgta      420

aaggaactcg tgcatgaggt cgcataccga caagaaaaga atgaaaatga ttggacatgt      480

gtgaatctga gtagtaccaa gttgacactg ctgcaaagaa agctccagcc cgacgcgatg      540

tatgagatta aagtgcggtc catccctaat gcgaactact tccagggctt ttggagcgag      600

tggtcaccct cttttcattt caggactcca gagattaccg ggcgaatgga cccggtgttg      660

cttacaatct ctattttgtc cttcttttct gtgacgctga tggtaatcct ggcctttgca      720

ctctggaaga agaggataaa gcctatggtt tggccttctc tcccggacca taaaaagacc      780

ctggagcaac tttgtaaaaa gccaaagaaa aacctcaatg tgtcctttaa ccccgagtca      840

ttcttggact gccagataca caaggtcgat gggattcagg ccagggacga agcagagtca      900

tttctccagg acacaagtcc ccagttggat gaaagcgaga agcagcggct gggtgggggt      960

ctgcaaggtc ctacttggcc cccagagcac gcggtcatca ctccaaaaac cttccgcggc     1020

gacccacctt ttggctgctt ggctgggaat gtaagcatgt tcgaggccct ggccttgcca     1080

tcatcccgca gcgctgattg cagggaaggc gggaaaaacg gaccccacgt gtaccaggga     1140

cttttgctcg gacccggaac gacctctgga acagtgccta ccccgttccc atttcagtca     1200

gggattctca ccccaaatcc tgccgcgcag ggccagccag ttctgacgtc tttggggagt     1260

tcacaggagg aggcttacgt gacaatgtcc agcttttatc agaaccagta a              1311


<210>  118
<211>  436
<212>  PRT
<213>  Canis familiaris

<400>  118

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Phe Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asp Gly Thr Gln 
            20                  25                  30          


His Leu Leu Thr Cys Thr Phe Asp Asp Pro Asp Ile Asn Ser Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Leu Asn Val Lys Cys Leu Thr 
    50                  55                  60                  


Phe Asn Lys Leu Gln Glu Met Tyr Phe Ile Lys Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Asp Ser Glu Ile Tyr Val Lys Leu Glu Gly Lys Asn Ile 
                85                  90                  95      


Thr Ser Lys Lys Leu Asn Ile Val Arg Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Val Arg Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Leu Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Glu Leu Val 
    130                 135                 140                 


His Glu Val Ala Tyr Arg Gln Glu Lys Asn Glu Asn Asp Trp Thr Cys 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Asp Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asn Ala Asn 
            180                 185                 190         


Tyr Phe Gln Gly Phe Trp Ser Glu Trp Ser Pro Ser Phe His Phe Arg 
        195                 200                 205             


Thr Pro Glu Ile Thr Gly Arg Met Asp Pro Val Leu Leu Thr Ile Ser 
    210                 215                 220                 


Ile Leu Ser Phe Phe Ser Val Thr Leu Met Val Ile Leu Ala Phe Ala 
225                 230                 235                 240 


Leu Trp Lys Lys Arg Ile Lys Pro Met Val Trp Pro Ser Leu Pro Asp 
                245                 250                 255     


His Lys Lys Thr Leu Glu Gln Leu Cys Lys Lys Pro Lys Lys Asn Leu 
            260                 265                 270         


Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Lys 
        275                 280                 285             


Val Asp Gly Ile Gln Ala Arg Asp Glu Ala Glu Ser Phe Leu Gln Asp 
    290                 295                 300                 


Thr Ser Pro Gln Leu Asp Glu Ser Glu Lys Gln Arg Leu Gly Gly Gly 
305                 310                 315                 320 


Leu Gln Gly Pro Thr Trp Pro Pro Glu His Ala Val Ile Thr Pro Lys 
                325                 330                 335     


Thr Phe Arg Gly Asp Pro Pro Phe Gly Cys Leu Ala Gly Asn Val Ser 
            340                 345                 350         


Met Phe Glu Ala Leu Ala Leu Pro Ser Ser Arg Ser Ala Asp Cys Arg 
        355                 360                 365             


Glu Gly Gly Lys Asn Gly Pro His Val Tyr Gln Gly Leu Leu Leu Gly 
    370                 375                 380                 


Pro Gly Thr Thr Ser Gly Thr Val Pro Thr Pro Phe Pro Phe Gln Ser 
385                 390                 395                 400 


Gly Ile Leu Thr Pro Asn Pro Ala Ala Gln Gly Gln Pro Val Leu Thr 
                405                 410                 415     


Ser Leu Gly Ser Ser Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            420                 425                 430         


Tyr Gln Asn Gln 
        435     


