                         SEQUENCE LISTING

<110>  Fundaci Hospital Universitari Vall d'Hebron- Institut de 
       Recerca
 
<120>  Antibodies or fragments thereof for use in the treatment of 
       ocular diseases.

<130>  P2195PC00

<150>  EP12382161
<151>  2012-04-30

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe 
    50                  55                  60                  


Val Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp 
65                  70                  75                  80  


Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg Gln Gly His Asn 
                85                  90                  95      


Ser Val Phe Leu Ile Lys Gly Asp Lys Val Trp Val Tyr Pro Pro Glu 
            100                 105                 110         


Lys Lys Glu Lys Gly Tyr Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly 
        115                 120                 125             


Ile Pro Ser Pro Leu Asp Ala Ala Val Glu Cys His Arg Gly Glu Cys 
    130                 135                 140                 


Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp 
145                 150                 155                 160 


Asp Leu Ala Thr Gly Thr Met Lys Glu Arg Ser Trp Pro Ala Val Gly 
                165                 170                 175     


Asn Cys Ser Ser Ala Leu Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln 
            180                 185                 190         


Gly Asn Gln Phe Leu Arg Phe Asp Pro Val Arg Gly Glu Val Pro Pro 
        195                 200                 205             


Arg Tyr Pro Arg Asp Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg 
    210                 215                 220                 


Gly His Gly His Arg Asn Gly Thr Gly His Gly Asn Ser Thr His His 
225                 230                 235                 240 


Gly Pro Glu Tyr Met Arg Cys Ser Pro His Leu Val Leu Ser Ala Leu 
                245                 250                 255     


Thr Ser Asp Asn His Gly Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr 
            260                 265                 270         


Trp Arg Leu Asp Thr Ser Arg Asp Gly Trp His Ser Trp Pro Ile Ala 
        275                 280                 285             


His Gln Trp Pro Gln Gly Pro Ser Ala Val Asp Ala Ala Phe Ser Trp 
    290                 295                 300                 


Glu Glu Lys Leu Tyr Leu Val Gln Gly Thr Gln Val Tyr Val Phe Leu 
305                 310                 315                 320 


Thr Lys Gly Gly Tyr Thr Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu 
                325                 330                 335     


Lys Glu Val Gly Thr Pro His Gly Ile Ile Leu Asp Ser Val Asp Ala 
            340                 345                 350         


Ala Phe Ile Cys Pro Gly Ser Ser Arg Leu His Ile Met Ala Gly Arg 
        355                 360                 365             


Arg Leu Trp Trp Leu Asp Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr 
    370                 375                 380                 


Glu Leu Pro Trp Pro His Glu Lys Val Asp Gly Ala Leu Cys Met Glu 
385                 390                 395                 400 


Lys Ser Leu Gly Pro Asn Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr 
                405                 410                 415     


Leu Ile His Gly Pro Asn Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu 
            420                 425                 430         


Asn Ala Ala Lys Ala Leu Pro Gln Pro Gln Asn Val Thr Ser Leu Leu 
        435                 440                 445             


Gly Cys Thr His 
    450         


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Leu Asp Asp Asn Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val 
1               5                   10                  15      


Trp Lys Ser His Lys Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys 
            20                  25                  30          


Asn Phe Pro Ser Pro Val Asp Ala Ala 
        35                  40      


<210>  3
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
1               5                   10                  15      


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            20                  25                  30          


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        35                  40                  45              


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    50                  55                  60                  


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
65                  70                  75                  80  


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                85                  90                  95      


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            100                 105                 110         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        115                 120                 125             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    130                 135                 140                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
145                 150                 155                 160 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                165                 170                 175     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            180                 185                 190         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        195                 200                 205             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    210                 215                 220                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
225                 230                 235                 240 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                245                 250                 255     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            260                 265                 270         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        275                 280                 285             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    290                 295                 300         


