                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
 
<120>  GENETIC CORRECTION OF MUTATED GENES

<130>  028193-9138-WO00

<140>  New International Patent Application
<141>  2013-04-26

<150>  61/639,227
<151>  2012-04-27

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  2
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln 
        675                 680                 685             


Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu 
    690                 695                 700                 


Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys 
705                 710                 715                 720 


Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg 
                725                 730                 735     


Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys Ser Glu 
            740                 745                 750         


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
        755                 760                 765             


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
    770                 775                 780                 


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
785                 790                 795                 800 


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
                805                 810                 815     


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
            820                 825                 830         


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
        835                 840                 845             


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
    850                 855                 860                 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
865                 870                 875                 880 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
                885                 890                 895     


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
            900                 905                 910         


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
        915                 920                 925             


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
    930                 935                 940         


<210>  3
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln 
        675                 680                 685             


Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu 
    690                 695                 700                 


Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys 
705                 710                 715                 720 


Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg 
                725                 730                 735     


Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys Ser Glu 
            740                 745                 750         


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
        755                 760                 765             


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
    770                 775                 780                 


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
785                 790                 795                 800 


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
                805                 810                 815     


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
            820                 825                 830         


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
        835                 840                 845             


Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
    850                 855                 860                 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
865                 870                 875                 880 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
                885                 890                 895     


Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
            900                 905                 910         


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
        915                 920                 925             


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
    930                 935                 940         


<210>  4
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  5
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  6
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  7
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  8
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val 
705                 710                 715                 720 


Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp 
                725                 730                 735     


His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala 
            740                 745                 750         


Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn 
        755                 760                 765             


Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys 
    770                 775                 780                 


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
785                 790                 795                 800 


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                805                 810                 815     


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            820                 825                 830         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        835                 840                 845             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    850                 855                 860                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
865                 870                 875                 880 


Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile 
                885                 890                 895     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            900                 905                 910         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        915                 920                 925             


Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser 
    930                 935                 940                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
945                 950                 955                 960 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                965                 970                 975     


<210>  9
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
705                 710                 715                 720 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                725                 730                 735     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            740                 745                 750         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        755                 760                 765             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    770                 775                 780                 


Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala 
785                 790                 795                 800 


Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro 
                805                 810                 815     


Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile 
            820                 825                 830         


Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala 
        835                 840                 845             


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
    850                 855                 860                 


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
865                 870                 875                 880 


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
                885                 890                 895     


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
            900                 905                 910         


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
        915                 920                 925             


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
    930                 935                 940                 


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
                965                 970                 975     


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
            980                 985                 990         


Tyr Lys Ala Gln Leu Thr Arg Leu  Asn Arg Lys Thr Asn  Cys Asn Gly 
        995                 1000                 1005             


Ala Val  Leu Ser Val Glu Glu  Leu Leu Ile Gly Gly  Glu Met Ile 
    1010                 1015                 1020             


Lys Ala  Gly Thr Leu Thr Leu  Glu Glu Val Arg Arg  Lys Phe Asn 
    1025                 1030                 1035             


Asn Gly  Glu Ile Asn Phe 
    1040                 


<210>  10
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
705                 710                 715                 720 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                725                 730                 735     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            740                 745                 750         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        755                 760                 765             


Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    770                 775                 780                 


Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala 
785                 790                 795                 800 


Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro 
                805                 810                 815     


Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile 
            820                 825                 830         


Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala 
        835                 840                 845             


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
    850                 855                 860                 


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
865                 870                 875                 880 


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
                885                 890                 895     


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
            900                 905                 910         


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
        915                 920                 925             


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
    930                 935                 940                 


Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Asp Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
                965                 970                 975     


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
            980                 985                 990         


Tyr Lys Ala Gln Leu Thr Arg Leu  Asn His Ile Thr Asn  Cys Asn Gly 
        995                 1000                 1005             


Ala Val  Leu Ser Val Glu Glu  Leu Leu Ile Gly Gly  Glu Met Ile 
    1010                 1015                 1020             


Lys Ala  Gly Thr Leu Thr Leu  Glu Glu Val Arg Arg  Lys Phe Asn 
    1025                 1030                 1035             


Asn Gly  Glu Ile Asn Phe 
    1040                 


<210>  11
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
705                 710                 715                 720 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                725                 730                 735     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            740                 745                 750         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
        755                 760                 765             


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    770                 775                 780                 


Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala 
785                 790                 795                 800 


Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro 
                805                 810                 815     


Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile 
            820                 825                 830         


Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala 
        835                 840                 845             


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
    850                 855                 860                 


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
865                 870                 875                 880 


Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
                885                 890                 895     


Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg 
            900                 905                 910         


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
        915                 920                 925             


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
    930                 935                 940                 


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
                965                 970                 975     


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
            980                 985                 990         


Tyr Lys Ala Gln Leu Thr Arg Leu  Asn Arg Lys Thr Asn  Cys Asn Gly 
        995                 1000                 1005             


Ala Val  Leu Ser Val Glu Glu  Leu Leu Ile Gly Gly  Glu Met Ile 
    1010                 1015                 1020             


Lys Ala  Gly Thr Leu Thr Leu  Glu Glu Val Arg Arg  Lys Phe Asn 
    1025                 1030                 1035             


Asn Gly  Glu Ile Asn Phe 
    1040                 


<210>  12
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
705                 710                 715                 720 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                725                 730                 735     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser 
            740                 745                 750         


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
        755                 760                 765             


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
    770                 775                 780                 


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
785                 790                 795                 800 


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu 
                805                 810                 815     


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
            820                 825                 830         


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
        835                 840                 845             


Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
    850                 855                 860                 


Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro 
865                 870                 875                 880 


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
                885                 890                 895     


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
            900                 905                 910         


Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys 
        915                 920                 925             


His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
    930                 935                 940                 


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
945                 950                 955                 960 


Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val 
                965                 970                 975     


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
            980                 985                 990         


Thr Leu Thr Leu Glu Glu Val Arg  Arg Lys Phe Asn Asn  Gly Glu Ile 
        995                 1000                 1005             


Asn Phe  
    1010 


<210>  13
<211>  1010
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        675                 680                 685             


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
    690                 695                 700                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
705                 710                 715                 720 


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
                725                 730                 735     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser 
            740                 745                 750         


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
        755                 760                 765             


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met 
    770                 775                 780                 


Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg 
785                 790                 795                 800 


Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu 
                805                 810                 815     


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
            820                 825                 830         


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
        835                 840                 845             


Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
    850                 855                 860                 


Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro 
865                 870                 875                 880 


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
                885                 890                 895     


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
            900                 905                 910         


Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys 
        915                 920                 925             


His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
    930                 935                 940                 


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
945                 950                 955                 960 


Ala Gln Leu Thr Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val 
                965                 970                 975     


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
            980                 985                 990         


Thr Leu Thr Leu Glu Glu Val Arg  Arg Lys Phe Asn Asn  Gly Glu Ile 
        995                 1000                 1005             


Asn Phe  
    1010 


<210>  14
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln 
        675                 680                 685             


Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu 
    690                 695                 700                 


Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys 
705                 710                 715                 720 


Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg 
                725                 730                 735     


Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys Ser Glu 
            740                 745                 750         


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
        755                 760                 765             


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
    770                 775                 780                 


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
785                 790                 795                 800 


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
                805                 810                 815     


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
            820                 825                 830         


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
        835                 840                 845             


Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
    850                 855                 860                 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
865                 870                 875                 880 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
                885                 890                 895     


Arg Leu Asn Arg Lys Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
            900                 905                 910         


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
        915                 920                 925             


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
    930                 935                 940         


<210>  15
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Ser Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
        35                  40                  45              


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
    50                  55                  60                  


Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr 
65                  70                  75                  80  


Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val Gly Val Gly Lys Gln 
                85                  90                  95      


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu 
            100                 105                 110         


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile 
        115                 120                 125             


Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala Val His Ala Ser Arg 
    130                 135                 140                 


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val 
145                 150                 155                 160 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
            180                 185                 190         


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
        195                 200                 205             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
    210                 215                 220                 


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
                245                 250                 255     


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            260                 265                 270         


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
        275                 280                 285             


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
    290                 295                 300                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
305                 310                 315                 320 


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
                325                 330                 335     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            340                 345                 350         


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
        355                 360                 365             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    370                 375                 380                 


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
385                 390                 395                 400 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                405                 410                 415     


Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val 
            420                 425                 430         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln 
    450                 455                 460                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
465                 470                 475                 480 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro 
                485                 490                 495     


Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            500                 505                 510         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu 
        515                 520                 525             


Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
    530                 535                 540                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His 
545                 550                 555                 560 


Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                565                 570                 575     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            580                 585                 590         


Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly 
        595                 600                 605             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    610                 615                 620                 


Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser 
625                 630                 635                 640 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                645                 650                 655     


Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile 
            660                 665                 670         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln 
        675                 680                 685             


Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu 
    690                 695                 700                 


Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys 
705                 710                 715                 720 


Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg 
                725                 730                 735     


Ile Gly Glu Arg Thr Ser His Arg Val Ala Gln Leu Val Lys Ser Glu 
            740                 745                 750         


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
        755                 760                 765             


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp 
    770                 775                 780                 


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
785                 790                 795                 800 


Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
                805                 810                 815     


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
            820                 825                 830         


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
        835                 840                 845             


Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg Asp Lys His Leu Asn Pro 
    850                 855                 860                 


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
865                 870                 875                 880 


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
                885                 890                 895     


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
            900                 905                 910         


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
        915                 920                 925             


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
    930                 935                 940         


<210>  16
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  16
tttagctcct actcagactg ttactctggt gacacaacct gtggttact                   49


<210>  17
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  17
tttagctcct actcagactg ttactctggt gacacaacct gtggttacta agg              53


<210>  18
<211>  46
<212>  DNA
<213>  Homo sapiens

<400>  18
agctcctact cagactgtta ctctggtgac acaacctgtg gttact                      46


<210>  19
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  19
agctcctact cagactgtta ctctggtgac acaacctgtg gttactaagg                  50


<210>  20
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  20
gcaaaaaccc aaaatatttt agctcctact cagactgtta ctctggtgac                  50


<210>  21
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  21
ttgcaaaaac ccaaaatatt ttagctccta ctcagactgt tactctggtg ac               52


<210>  22
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  22
cctttttgca aaaacccaaa atattttagc tcctactcag actgttactc tggtg            55


<210>  23
<211>  56
<212>  DNA
<213>  Homo sapiens

<400>  23
ccaaactaga aatgccatct tccttgatgt tggaggtacc tgctctggca gatttc           56


<210>  24
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  24
ctatagatga gattatctgc ccatgactgg cgcagggatg gccgcattgc t                51


<210>  25
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  25
tggaatttga aatatccggg ggcctctaca gaatcctggc atcagtta                    48


<210>  26
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  26
attttagctc ctact                                                        15


<210>  27
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  27
tttagctcct actcaga                                                      17


<210>  28
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  28
agctcctact cagact                                                       16


<210>  29
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  29
cctactcaga ctgtt                                                        15


<210>  30
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  30
aaccacaggt tgtgtca                                                      17


<210>  31
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  31
agtaaccaca ggttgt                                                       16


<210>  32
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  32
ccttagtaac cacaggt                                                      17


<210>  33
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  33
gcaaaaaccc aaaatat                                                      17


<210>  34
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  34
ttgcaaaaac ccaaaat                                                      17


<210>  35
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  35
cctttttgca aaaaccc                                                      17


<210>  36
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  36
caccagagta acagtct                                                      17


<210>  37
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  37
gtcaccagag taacagtct                                                    19


<210>  38
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  38
ccaaactaga aatgccat                                                     18


<210>  39
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  39
gaaatctgcc agagcaggt                                                    19


<210>  40
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  40
ctatagatga gattatct                                                     18


<210>  41
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  41
agcaatgcgg ccatccct                                                     18


<210>  42
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  42
taactgatgc caggatt                                                      17


<210>  43
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  43
tggaatttga aatatcc                                                      17


<210>  44
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (18)..(31)
<223>  n is a, c, g, or t

<400>  44
tggaatttga aatatccnnn nnnnnnnnnn naatcctggc atcagtta                    48


<210>  45
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  45
tggaatttga aatatccaga ggcctctaca gaatcctggc atcagtta                    48


<210>  46
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  46
tattttagct cctactcaga ctgttactct ggtgacacaa cctgtggtta ctaag            55


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Leu Leu Arg Leu Leu Leu Trp 
1               5               


<210>  48
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Tyr Ser Asp Cys Tyr Ser Gly Asp Thr Thr Cys Gly Tyr 
1               5                   10                  


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys 
1               5                   10                  15  


<210>  50
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<400>  50
tattttagct cctactcaga ctgttanctc tggtgacaca acctgtggtt actaag           56


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Leu Leu Leu Arg Leu Leu Xaa Leu Val Thr Gln Pro Val Val Thr Lys 
1               5                   10                  15      


<210>  52
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a, c, g, or t

<400>  52
tattttagct cctactcaga ctgttannct ctggtgacac aacctgtggt tactaag          57


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Ser Tyr Ser Asp Cys Xaa Xaa Leu Val Thr Gln Pro Val Val Thr Lys 
1               5                   10                  15      


<210>  54
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  54
attttagctc ctact                                                        15


<210>  55
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  55
tttagctcct actcaga                                                      17


<210>  56
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  56
agctcctact cagact                                                       16


<210>  57
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  57
cctactcaga ctgtt                                                        15


<210>  58
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  58
aaaatatttt agctcctact cagactgtta ctctggtgac acaacctgtg gttactaagg       60

a                                                                       61


<210>  59
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  59
tccttagtaa ccacaggttg tgtcaccaga gtaacagtct gagtaggagc taaaatattt       60

t                                                                       61


<210>  60
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gagtttggct caaattgtta ctctt                                             25


<210>  61
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
gggaaatggt ctaggagagt aaagt                                             25


<210>  62
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
agactgttac tcttggtgac acaacctgtg ttac                                   34


<210>  63
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  63
aaaaacccaa aatattttag ctcctactca gactgttact ctggtgacac aacctgtgg        59


<210>  64
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
aaaaacccaa aatattttag ctcctactca gactgttact gtgacacaac ctgtgg           56


<210>  65
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
aaaaacccaa aatattttag ctcctactca gactgtgg                               38


<210>  66
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
aaaaacccaa aatattttag ctcctactca gactgttact cttgacacaa cctgtgg          57


<210>  67
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
aaaacccaaa atattttagc tcctactcag actgttacac aacctgtgg                   49


<210>  68
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
aaaaacccaa aatattttag ctcctactca gactgttact ggtgacacaa cctgtgg          57


<210>  69
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (42)..(224)
<223>  n is a, c, g, or t

<400>  69
aaaaacccaa aatattttag ctcctactca gactgttact cnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnggtgac acaacctgtg      240

g                                                                      241


<210>  70
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
aaaaccccaa aattttttag ctccttctca gactttttct ggtgacacaa cctgtgg          57


<210>  71
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
aaaaacccaa aatattttag ctcctactca gactgttact cttggtgaca caacctgtgg       60


<210>  72
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
aaaaacccaa aatattttag ctcctactca gactgttact ctgcaacctg tgg              53


<210>  73
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
aaaaacccaa aatattttag ctcctactca gactgttacg gtgacacaac ctgtgg           56


<210>  74
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
aaaaacccaa aatattttag ctcctactca gactgttact ctggtgacac aacctgtgg        59


<210>  75
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  75
agactgttac tctggtgaca caacctgtgg ttac                                   34


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
agactgtttg gtgacacaac ctgtggttac                                        30


<210>  77
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
agactgttac tctgtgacac aacctgtggt tac                                    33


<210>  78
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
agactgtgac acaacctgtg gttac                                             25


<210>  79
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
agactgttac tgacacaacc tgtggttac                                         29


<210>  80
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
agactgttac tctgacacaa cctgtggtta c                                      31


<210>  81
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
agactgttac tgtgacacaa cctgtggtta c                                      31


<210>  82
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
agactgttac tctgacacaa cctgtggtta c                                      31


<210>  83
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  83
agactgttac tctggtgaca caacctgtgg ttac                                   34


<210>  84
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
agactgttac tgtgacacaa cctgtggtta c                                      31


<210>  85
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
agactgtggt tac                                                          13


<210>  86
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
agactgttac tcttgacaca acctgtggtt ac                                     32


<210>  87
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
agactgttac acaacctgtg gttac                                             25


<210>  88
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
agactgttac tggtgacaca acctgtggtt ac                                     32


<210>  89
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (13)..(195)
<223>  n is a, c, g, or t

<400>  89
agactgttac tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnggtga cacaacctgt ggttac                                216


<210>  90
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
agactgttac tggtgacaca acctgtggtt ac                                     32


<210>  91
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
agactgttac tctgcaacct gtggttac                                          28


<210>  92
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
agactgttac ggtgacacaa cctgtggtta c                                      31


<210>  93
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  93
agactgttac tctggtgaca caacctgtgt tac                                    33


