                         SEQUENCE LISTING

<110>  Amylin Pharmaceuticals, LLC
       Astrazeneca Pharmaceuticals LP
       Samant, Manoj  P.
       D'Souza, Lawrence
       Levy, Odile  E.
       Ghosh, Soumitra  S.
       Soares, Christopher  J.
 
<120>  Site-Specific Enzymatic Modification of Exendins and Analogs 
       Thereof

<130>  A68761 1210WO

<150>  61/637,393
<151>  2012-04-24

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rat amylin

<400>  1

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  2
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human amylin

<400>  2

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  3
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pramlintide

<400>  3

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  4
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adrenomedullin (ADM) preprohormone

<400>  4

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  5
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adrenomedullin (ADM)

<400>  5

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp 
        35          


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Salmon CT(1-32)

<400>  6

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  7
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermedin

<400>  7

Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu Gly Thr Cys Gln 
1               5                   10                  15      


Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met Gly Pro Ala Gly 
            20                  25                  30          


Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro His Ser Tyr 
        35                  40                  45          


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preprocholecystokinin

<400>  8

Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Thr Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Thr Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210>  9
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human leptin

<400>  9

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  10
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Metreleptin

<400>  10

Met Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu Ile Lys 
1               5                   10                  15      


Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser Val Ser 
            20                  25                  30          


Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro 
        35                  40                  45              


Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala Val Tyr Gln Gln 
    50                  55                  60                  


Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln Ile Ser Asn Asp 
65                  70                  75                  80  


Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser 
                85                  90                  95      


Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly 
            100                 105                 110         


Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser 
        115                 120                 125             


Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln Leu Asp Leu Ser 
    130                 135                 140                 


Pro Gly Cys 
145         


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pancreatic polypeptide


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  11

Ala Pro Leu Glu Pro Val Tyr Pro Gly Asp Asn Ala Thr Pro Glu Gln 
1               5                   10                  15      


Met Ala Gln Tyr Ala Ala Asp Leu Arg Arg Tyr Ile Asn Met Leu Thr 
            20                  25                  30          


Arg Pro Arg Tyr 
        35      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PYY


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  12

Tyr Pro Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu 
1               5                   10                  15      


Leu Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPY


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  13

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37)


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  14

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A, V, or G

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  G, K, or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  A or E

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  V or K

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  K, N, or R

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  R or G

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  G, H, P, or absent

<400>  15

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa 
1               5                   10                  15      


Xaa Ala Ala Lys Glu Phe Ile Xaa Trp Leu Xaa Xaa Gly Xaa Xaa 
            20                  25                  30      


<210>  16
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc portion of an immunoglobulin


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  P or E

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  F, V, or A

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  L, E, or A

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  N or A

<220>
<221>  MISC_FEATURE
<222>  (230)..(230)
<223>  K or absent

<400>  16

Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Xaa 
1               5                   10                  15      


Xaa Xaa Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Xaa 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly Xaa 
225                 230 


<210>  17
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1(7-37) analog covalently linked to the Fc portion of an 
       immunoglobulin

<400>  17

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  18
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-2

<400>  18

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  19
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXM (also known as "glucagon-37")

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Lys Asn Asn Ile Ala 
        35          


<210>  20
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human natriuretic peptides A preprotein

<400>  20

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ANP

<400>  21

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat BNP

<400>  22

Met Asp Leu Gln Lys Val Leu Pro Gln Met Ile Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Leu Ser Pro Leu Gly Gly His Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Ser Gln Ser Pro Glu Gln Ser Thr Met Gln Lys Leu Leu Glu Leu Ile 
        35                  40                  45              


Arg Glu Lys Ser Glu Glu Met Ala Gln Arg Gln Leu Ser Lys Asp Gln 
    50                  55                  60                  


Gly Pro Thr Lys Glu Leu Leu Lys Arg Val Leu Arg Ser Gln Asp Ser 
65                  70                  75                  80  


Ala Phe Arg Ile Gln Glu Arg Leu Arg Asn Ser Lys Met Ala His Ser 
                85                  90                  95      


Ser Ser Cys Phe Gly Gln Lys Ile Asp Arg Ile Gly Ala Val Ser Arg 
            100                 105                 110         


Leu Gly Cys Asp Gly Leu Arg Leu Phe 
        115                 120     


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat BNP

<400>  23

Asn Ser Lys Met Ala His Ser Ser Ser Cys Phe Gly Gln Lys Ile Asp 
1               5                   10                  15      


Arg Ile Gly Ala Val Ser Arg Leu Gly Cys Asp Gly Leu Arg Leu Phe 
            20                  25                  30          


<210>  24
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  porcine C-type natriuretic peptide precursor

<400>  24

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Val Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  porcine CNP

<400>  25

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  26
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human urocortin 1


<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  26

Asp Asn Pro Ser Leu Ser Ile Asp Leu Thr Phe His Leu Leu Arg Thr 
1               5                   10                  15      


Leu Leu Glu Leu Ala Arg Thr Gln Ser Gln Arg Glu Arg Ala Glu Gln 
            20                  25                  30          


Asn Arg Ile Ile Phe Asp Ser Val 
        35                  40  


<210>  27
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Ucn-2

<400>  27

Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Ala Arg Ala Arg Ala Ala Arg Glu Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val Gly His Cys 
        35                  40      


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Ucn-3

<400>  28

Phe Thr Leu Ser Leu Asp Val Pro Thr Asn Ile Met Asn Leu Leu Phe 
1               5                   10                  15      


Asn Ile Ala Lys Ala Lys Asn Leu Arg Ala Gln Ala Ala Ala Asn Ala 
            20                  25                  30          


His Leu Met Ala Gln Ile 
        35              


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neuromedin-U25

<400>  29

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pig U25

<400>  30

Phe Lys Val Asp Glu Glu Phe Gln Gly Pro Ile Val Ser Gln Asn Arg 
1               5                   10                  15      


Arg Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  31
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neuromedin U family truncated or splice variant

<400>  31

Phe Leu Phe His Tyr Ser Lys Thr Gln Lys Leu Gly Lys Ser Asn Val 
1               5                   10                  15      


Val Glu Glu Leu Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
            20                  25                  30          


Leu Phe Arg Pro Arg Asn 
        35              


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human neuromedin S

<400>  32

Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys Lys 
1               5                   10                  15      


Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro Arg 
            20                  25                  30          


Asn 
    


<210>  33
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-3


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  33

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  34
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  34

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [14Leu]exendin-4

<400>  35

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  36
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4 peptide analog

<400>  36

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Lys Glu Ile Ile Ser 
        35          


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP 1(7 36)NH2


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  37

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exendin-4(1-30)

<400>  38

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog agonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  His, Arg or Tyr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Ser, Gly, Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Phe, Tyr or naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Leu, Ile, Val, pentylglycine or Met

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Leu, Ile, pentylglycine, Val or Met

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Phe, Tyr or naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Ile, Val, Leu, pentylglycine, tert-butylglycine or Met

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Trp, Phe, Tyr, or naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, 
       N-alkylpentylglycine or N-alkylalanine or absent

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, 
       N-alkylpentylglycine or N-alkylalanine or absent

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, 
       N-alkylpentylglycine or N-alkylalanine or absent

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, 
       N-alkylpentylglycine or N-alkylalanine or absent

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser, Thr or Tyr or absent

<400>  39

Xaa Xaa Xaa Gly Thr Xaa Xaa Xaa Xaa Xaa Ser Lys Gln Xaa Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Xaa Xaa Xaa Xaa Leu Lys Asn Gly Gly Xaa Ser 
            20                  25                  30          


Ser Gly Ala Xaa Xaa Xaa Xaa 
        35                  


<210>  40
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog agonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  His, Arg or Tyr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Ser, Gly, Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ala, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Ala, Phe, Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Ala, Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Ala, Leu, Ile, Val, or Met

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Ala or Lys

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Ala or Gln

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Ala, Leu, Ile, , Val or Met

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Ala or Ar

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Ala or Leu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Ala, Phe, Tyr

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Ile, Val, Leu, or Met

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Ala, Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Ala, Trp, Phe, Tyr

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Ala or Leu

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Ala or Lys

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ala or Asn

<400>  40

Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25              


<210>  41
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  41

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  


<210>  42
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  42

Lys Lys Lys Lys Lys Lys His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys 
        35                  40                  45              


Lys Lys 
    50  


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  43

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Trp Leu Lys Asn Gly Gly 
            20                  25                  30          


Pro Ser Ser Gly Ala Ser 
        35              


<210>  44
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  44

Lys Lys Lys Lys Lys Lys His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Ser 
        35                  40          


<210>  45
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  45

Asn Glu Glu Glu Glu Glu His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Ser 
        35                  40          


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  46

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Ser Lys Lys Lys Lys Lys Lys 
        35                  40          


<210>  47
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  47

Lys Lys Lys Lys Lys Lys His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  45              


<210>  48
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  48

Asp Glu Glu Glu Glu Glu His Gly Glu Gly Thr Phe Thr Ser Asp Leu 
1               5                   10                  15      


Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu 
            20                  25                  30          


Lys Asn Gly Gly Pro Ser Ser Gly Ala Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  45              


<210>  49
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  49

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Lys Cys Asn Thr Ala Thr 
        35                  40                  45              


Cys Val Leu Gly Arg Leu Ser Gln Glu Leu His Arg Leu Gln Thr Tyr 
    50                  55                  60                  


Pro Arg Thr Asn Thr Gly Ser Asn Thr Tyr 
65                  70                  


<210>  50
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog


<220>
<221>  MOD_RES
<222>  (74)..(74)
<223>  AMIDATION

<400>  50

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Gly Gly Gly Lys Cys Asn Thr Ala Thr 
        35                  40                  45              


Cys Val Leu Gly Arg Leu Ser Gln Glu Leu His Arg Leu Gln Thr Tyr 
    50                  55                  60                  


Pro Arg Thr Asn Thr Gly Ser Asn Thr Tyr 
65                  70                  


<210>  51
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog

<400>  51

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Lys Glu Ile Ile Ser Gly Gly Gly Lys Cys Asn Thr Ala Thr Cys Val 
        35                  40                  45              


Leu Gly Arg Leu Ser Gln Glu Leu His Arg Leu Gln Thr Tyr Pro Arg 
    50                  55                  60                  


Thr Asn Thr Gly Ser Asn Thr Tyr 
65                  70          


<210>  52
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin analog


<220>
<221>  MOD_RES
<222>  (72)..(72)
<223>  AMIDATION

<400>  52

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Gln Gly Gly Pro Ser 
            20                  25                  30          


Lys Glu Ile Ile Ser Gly Gly Gly Lys Cys Asn Thr Ala Thr Cys Val 
        35                  40                  45              


Leu Gly Arg Leu Ser Gln Glu Leu His Arg Leu Gln Thr Tyr Pro Arg 
    50                  55                  60                  


Thr Asn Thr Gly Ser Asn Thr Tyr 
65                  70          


<210>  53
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zot from V. cholerae BX 330286

<400>  53

Met Ser Ile Phe Ile His His Gly Ala Pro Gly Ser Tyr Lys Thr Ser 
1               5                   10                  15      


Gly Ala Leu Trp Leu Arg Leu Leu Pro Ala Ile Lys Ser Gly Arg His 
            20                  25                  30          


Ile Ile Thr Asn Val Arg Gly Leu Asn Leu Glu Arg Met Ala Lys Tyr 
        35                  40                  45              


Leu Lys Met Asp Val Ser Asp Ile Ser Ile Glu Phe Ile Asp Thr Asp 
    50                  55                  60                  


His Pro Asp Gly Arg Leu Thr Met Ala Arg Phe Trp His Trp Ala Arg 
65                  70                  75                  80  


Lys Asp Ala Phe Leu Phe Ile Asp Glu Cys Gly Arg Ile Trp Pro Pro 
                85                  90                  95      


Arg Leu Thr Ala Thr Asn Leu Lys Ala Leu Asp Thr Pro Pro Asp Leu 
            100                 105                 110         


Val Ala Glu Asp Arg Pro Glu Ser Phe Glu Val Ala Phe Asp Met His 
        115                 120                 125             


Arg His His Gly Trp Asp Ile Cys Leu Thr Thr Pro Asn Ile Ala Lys 
    130                 135                 140                 


Val His Asn Met Ile Arg Glu Ala Ala Glu Ile Gly Tyr Arg His Phe 
145                 150                 155                 160 


Asn Arg Ala Thr Val Gly Leu Gly Ala Lys Phe Thr Leu Thr Thr His 
                165                 170                 175     


Asp Ala Ala Asn Ser Gly Gln Met Asp Ser His Ala Leu Thr Arg Gln 
            180                 185                 190         


Val Lys Lys Ile Pro Ser Pro Ile Phe Lys Met Tyr Ala Ser Thr Thr 
        195                 200                 205             


Thr Gly Lys Ala Arg Asp Thr Met Ala Gly Thr Ala Leu Trp Lys Asp 
    210                 215                 220                 


Arg Lys Ile Leu Phe Leu Phe Gly Met Val Phe Leu Met Phe Ser Tyr 
225                 230                 235                 240 


Ser Phe Tyr Gly Leu His Asp Asn Pro Ile Phe Thr Gly Gly Asn Asp 
                245                 250                 255     


Ala Thr Ile Glu Ser Glu Gln Ser Glu Pro Gln Ser Lys Ala Thr Ala 
            260                 265                 270         


Gly Asn Ala Val Gly Ser Lys Ala Val Ala Pro Ala Ser Phe Gly Phe 
        275                 280                 285             


Cys Ile Gly Arg Leu Cys Val Gln Asp Gly Phe Val Thr Val Gly Asp 
    290                 295                 300                 


Glu Arg Tyr Arg Leu Val Asp Asn Phe Asp Ile Pro Tyr Arg Gly Leu 
305                 310                 315                 320 


Trp Ala Thr Gly His His Ile Tyr Lys Asp Thr Leu Thr Val Phe Phe 
                325                 330                 335     


Glu Thr Glu Ser Gly Ser Val Pro Thr Glu Leu Phe Ala Ser Ser Tyr 
            340                 345                 350         


Arg Tyr Lys Val Leu Pro Leu Pro Asp Phe Asn His Phe Val Val Phe 
        355                 360                 365             


Asp Thr Phe Thr Ala Gln Ala Leu Trp Val Glu Val Lys Arg Gly Leu 
    370                 375                 380                 


Pro Ile Lys Thr Glu Asn Asp Lys Lys Gly Leu Asn Ser Ile Phe 
385                 390                 395                 


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zot from V. cholerae BX 330286 (residues 288-293)

<400>  54

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zot peptide or analog thereof


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  surrogate for cysteine

<400>  55

Phe Xaa Ile Gly Arg Leu Lys 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zot peptide or analog thereof


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  allylglycine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  56

Phe Xaa Ile Gly Arg Leu Lys 
1               5           


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  57

Gly Pro Asn Gly Gly 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  58

Lys Lys Lys Lys Lys 
1               5   


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  59

Pro Pro Pro Pro Pro Pro 
1               5       


