                         SEQUENCE LISTING

<110>  Gevo, Inc.
       VIB VZW
       Katholieke Universiteit Leuven, K.U. Leuven R&D
       Asleson Dundon, Catherine
       Reddy, Vaka
       Thevelein, Johan
       De Graeve, Stijn
 
<120>  ENGINEERED MICROORGANISMS WITH IMPROVED GROWTH PROPERTIES

<130>  GEVO-078/02WO 310142-2423

<150>  US 61/779,498
<151>  2013-03-13

<150>  US 61/625,324
<151>  2012-04-17

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1470
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atgtctgctg atttcggttt gattggtttg gccgtcatgg gtcaaaattt gatcttgaac       60

gctgctgacc acggtttcac tgtttgtgct tacaacagaa ctcaatccaa ggtcgaccat      120

ttcttggcca atgaagctaa gggcaaatct atcatcggtg ctacttccat tgaagatttc      180

atctccaaat tgaagagacc tagaaaggtc atgcttttgg ttaaagctgg tgctccagtt      240

gacgctttga tcaaccaaat cgtcccactt ttggaaaagg gtgatattat catcgatggt      300

ggtaactctc acttcccaga ttctaataga cgttacgaag aattgaagaa gaagggtatt      360

cttttcgttg gttctggtgt ctccggtggt gaggaaggtg cccgttacgg tccatctttg      420

atgccaggtg gttctgaaga agcttggcca catattaaga acatcttcca atccatctct      480

gctaaatccg acggtgaacc atgttgcgaa tgggttggcc cagccggtgc tggtcactac      540

gtcaagatgg ttcacaacgg tattgaatac ggtgatatgc aattgatttg tgaagcttat      600

gacatcatga agagattggg tgggtttacc gataaggaaa tcagtgacgt ttttgccaaa      660

tggaacaatg gtgtcttgga ttccttcttg gtcgaaatta ccagagatat tttgaaattc      720

gacgacgtcg acggtaagcc attagttgaa aaaatcatgg atactgctgg tcaaaagggt      780

actggtaagt ggactgccat caacgccttg gatttgggta tgccagttac tttgattggt      840

gaagctgtct ttgcccgttg tctatctgct ttgaagaacg agagaattag agcctccaag      900

gtcttaccag gcccagaagt tccaaaagac gccgtcaagg acagagaaca atttgtcgat      960

gatttggaac aagctttgta tgcttccaag attatttctt acgctcaagg tttcatgttg     1020

atccgtgaag ctgctgctac ttatggctgg aaactaaaca accctgccat cgctttgatg     1080

tggagaggtg gttgtatcat tagatctgtt ttcttgggtc aaatcacaaa ggcctacaga     1140

gaagaaccag atttggaaaa cttgttgttc aacaagttct tcgctgatgc cgtcaccaag     1200

gctcaatctg gttggagaaa gtcaattgcg ttggctacca cctacggtat cccaacacca     1260

gccttttcca ccgctttgtc tttctacgat gggtacagat ctgaaagatt gccagccaac     1320

ttactacaag ctcaacgtga ctactttggt gctcacactt tcagagtgtt gccagaatgt     1380

gcttctgaca acttgccagt agacaaggat atccatatca actggactgg ccacggtggt     1440

aatgtttctt cctctacata ccaagcttaa                                      1470


<210>  2
<211>  489
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Gln Ser Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Phe Ile Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Asn Gln Ile Val Pro Leu Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Lys Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Leu Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Asp Val Phe Ala Lys Trp Asn Asn Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Val Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Asn Glu Arg Ile Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Glu Val Pro Lys Asp Ala Val Lys Asp Arg Glu Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Ala Ala Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Gln Ile Thr Lys Ala Tyr Arg Glu Glu Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ser Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Asn 
    450                 455                 460                 


Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  3
<211>  2511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified UME6 Nucleotide Sequence

<400>  3
atgctagaca aggcgcgctc tcaaagcaaa cacatggacg aatctaatgc ggctgcctct       60

ctgctttcga tggaaacaac cgccaacaat catcactatt tgcacaataa aacatctcgt      120

gccacgctga tgaatagcag ccaagacggc aaaaaacatg cagaagatga agttagtgat      180

ggagctaact cccgccatcc tacaatttcc agtgctagca tcgaatctct caagacaacc      240

tacgatgaaa accctttgct ttctattatg aaatcgacat gtgcgcccaa caacactccc      300

gtgcatactc cgtctggttc gccgagtttg aaagtccaaa gtggcggaga tatcaaagac      360

gatcctaagg aaaacgatac tactactacg accaatacta cacttcaaga tcgccgtgac      420

agcgataacg ctgtgcatgc tgccgccagc ccactcgcgc cttccaatac accttcggat      480

cctaagtcat tgtgcaatgg ccatgtcgca caggctacag acccacaaat ttccggtgct      540

attcagccgc agtatactgc aaccaacgag gatgttttcc cttactcctc cacctccact      600

aatagtaaca ctgccactac tactatcgtc gccggcgcca aaaaaaaaat acatttgccg      660

ccaccacaag ctccagcggt ttcttccccc ggtaccaccg cagcaggctc gggcgcgggc      720

acgggctcgg gcatccgttc ccgcacagga tcggatttgc cgctcatcat taccagcgcc      780

aacaagaaca acggtaagac taccaattcg cctatgtcga tactgagcag aaacaacagt      840

accaacaaca acgacaataa ttcgatacaa agctcagatt cgagagaatc ctctaataac      900

aatgagattg gcgggtattt gcgcggcgga actaagcgcg gcggcagtcc atctaacgac      960

tctcaggtcc agcataatgt gcatgatgac caatgtgccg tgggcgtggc gcccaggaac     1020

ttctatttca acaaggatag agagataaca gacccaaatg taaaactgga cgagaacgaa     1080

tcaaaaatca acatatcgtt ctggctaaat tcgaaataca gagatgaggc ttattctttg     1140

aatgaatcat cctccaacaa tgctagttca aacacggata cgcctacaaa ctctcgacat     1200

gcgaacacca gctcttccat taccagcaga aacaatttcc agcattttag gttcaaccaa     1260

ataccttctc aacctccaac ttccgcatct tcgtttacaa gcacaaacaa caacaaccct     1320

caacggaaca atatcaatcg cggtgaagac ccgtttgcca cttcgtcaag accttctact     1380

gggttttttt acggcgattt gccgaatcgt aacaatagaa atagtccctt ccatacaaat     1440

gaacaataca tcccaccacc tccaccgaaa tacatcaatt ctaaattgga tggattgaga     1500

tcaagattat tgctcggtcc gaattctgca tcttcatcta ccaaactaga cgacgacttg     1560

ggtacagcag cagcagtgct atcaaacatg agatcatccc catatagaac tcatgataaa     1620

cccatttcca atgtcaatga catgaataac acaaatgcgc tcggtgtgcc ggctagtagg     1680

cctcattcgt catcttttcc atcaaagggt gtcttaagac caattctgtt acgtatccat     1740

aattccgaac aacaacccat tttcgaaagc aacaattcta cagctgtttt tgatgaagac     1800

caggaccaaa atcaagactt gtctccttac catttaaatc taaactctaa aaaggtttta     1860

gatcccactt ttgagtcaag gacaaggcaa gttacttgga ataagaatgg taagcgaata     1920

gacagacgcc tttctgctcc agaacaacaa cagcaactgg aagttccacc attgaaaaaa     1980

tcgagaaggt cagttggaaa cgcaagagta gcaagccaaa ccaatagcga ttataattct     2040

cttggcgaat cctcaacttc gtcagctcca tcgtctccat ctttgaaggc ttcttctggc     2100

ttggcatata ccgctgatta tcctaacgct acttcgccgg atttcgctaa atctaaagga     2160

aaaaatgtca agcctaaggc aaaatcaaag gcgaaacagt catcaaagaa aagaccaaat     2220

aatactactt cgaaatcaaa agcaaacaat tctcaagaat cgaataatgc tacttcctca     2280

acgtctcaag gtacaaggtc ccgtactggt tgctggattt gtagattaag gaaaaagaag     2340

tgtaccgagg aaagaccgca ctgtttcaac tgtgaaaggt tgaaattgga ctgtcactat     2400

gacgcgttca aaccagattt tgtatctgat ccaaagaaaa aacagatgaa actggaggaa     2460

atcaagaaaa aaacaaaaga ggccaaaaga agagcaatga aaaaaaaata a              2511


<210>  4
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Ume6p Polypeptide Sequence

<400>  4

Met Leu Asp Lys Ala Arg Ser Gln Ser Lys His Met Asp Glu Ser Asn 
1               5                   10                  15      


Ala Ala Ala Ser Leu Leu Ser Met Glu Thr Thr Ala Asn Asn His His 
            20                  25                  30          


Tyr Leu His Asn Lys Thr Ser Arg Ala Thr Leu Met Asn Ser Ser Gln 
        35                  40                  45              


Asp Gly Lys Lys His Ala Glu Asp Glu Val Ser Asp Gly Ala Asn Ser 
    50                  55                  60                  


Arg His Pro Thr Ile Ser Ser Ala Ser Ile Glu Ser Leu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Glu Asn Pro Leu Leu Ser Ile Met Lys Ser Thr Cys Ala Pro 
                85                  90                  95      


Asn Asn Thr Pro Val His Thr Pro Ser Gly Ser Pro Ser Leu Lys Val 
            100                 105                 110         


Gln Ser Gly Gly Asp Ile Lys Asp Asp Pro Lys Glu Asn Asp Thr Thr 
        115                 120                 125             


Thr Thr Thr Asn Thr Thr Leu Gln Asp Arg Arg Asp Ser Asp Asn Ala 
    130                 135                 140                 


Val His Ala Ala Ala Ser Pro Leu Ala Pro Ser Asn Thr Pro Ser Asp 
145                 150                 155                 160 


Pro Lys Ser Leu Cys Asn Gly His Val Ala Gln Ala Thr Asp Pro Gln 
                165                 170                 175     


Ile Ser Gly Ala Ile Gln Pro Gln Tyr Thr Ala Thr Asn Glu Asp Val 
            180                 185                 190         


Phe Pro Tyr Ser Ser Thr Ser Thr Asn Ser Asn Thr Ala Thr Thr Thr 
        195                 200                 205             


Ile Val Ala Gly Ala Lys Lys Lys Ile His Leu Pro Pro Pro Gln Ala 
    210                 215                 220                 


Pro Ala Val Ser Ser Pro Gly Thr Thr Ala Ala Gly Ser Gly Ala Gly 
225                 230                 235                 240 


Thr Gly Ser Gly Ile Arg Ser Arg Thr Gly Ser Asp Leu Pro Leu Ile 
                245                 250                 255     


Ile Thr Ser Ala Asn Lys Asn Asn Gly Lys Thr Thr Asn Ser Pro Met 
            260                 265                 270         


Ser Ile Leu Ser Arg Asn Asn Ser Thr Asn Asn Asn Asp Asn Asn Ser 
        275                 280                 285             


Ile Gln Ser Ser Asp Ser Arg Glu Ser Ser Asn Asn Asn Glu Ile Gly 
    290                 295                 300                 


Gly Tyr Leu Arg Gly Gly Thr Lys Arg Gly Gly Ser Pro Ser Asn Asp 
305                 310                 315                 320 


Ser Gln Val Gln His Asn Val His Asp Asp Gln Cys Ala Val Gly Val 
                325                 330                 335     


Ala Pro Arg Asn Phe Tyr Phe Asn Lys Asp Arg Glu Ile Thr Asp Pro 
            340                 345                 350         


Asn Val Lys Leu Asp Glu Asn Glu Ser Lys Ile Asn Ile Ser Phe Trp 
        355                 360                 365             


Leu Asn Ser Lys Tyr Arg Asp Glu Ala Tyr Ser Leu Asn Glu Ser Ser 
    370                 375                 380                 


Ser Asn Asn Ala Ser Ser Asn Thr Asp Thr Pro Thr Asn Ser Arg His 
385                 390                 395                 400 


Ala Asn Thr Ser Ser Ser Ile Thr Ser Arg Asn Asn Phe Gln His Phe 
                405                 410                 415     


Arg Phe Asn Gln Ile Pro Ser Gln Pro Pro Thr Ser Ala Ser Ser Phe 
            420                 425                 430         


Thr Ser Thr Asn Asn Asn Asn Pro Gln Arg Asn Asn Ile Asn Arg Gly 
        435                 440                 445             


Glu Asp Pro Phe Ala Thr Ser Ser Arg Pro Ser Thr Gly Phe Phe Tyr 
    450                 455                 460                 


Gly Asp Leu Pro Asn Arg Asn Asn Arg Asn Ser Pro Phe His Thr Asn 
465                 470                 475                 480 


Glu Gln Tyr Ile Pro Pro Pro Pro Pro Lys Tyr Ile Asn Ser Lys Leu 
                485                 490                 495     


Asp Gly Leu Arg Ser Arg Leu Leu Leu Gly Pro Asn Ser Ala Ser Ser 
            500                 505                 510         


Ser Thr Lys Leu Asp Asp Asp Leu Gly Thr Ala Ala Ala Val Leu Ser 
        515                 520                 525             


Asn Met Arg Ser Ser Pro Tyr Arg Thr His Asp Lys Pro Ile Ser Asn 
    530                 535                 540                 


Val Asn Asp Met Asn Asn Thr Asn Ala Leu Gly Val Pro Ala Ser Arg 
545                 550                 555                 560 


Pro His Ser Ser Ser Phe Pro Ser Lys Gly Val Leu Arg Pro Ile Leu 
                565                 570                 575     


Leu Arg Ile His Asn Ser Glu Gln Gln Pro Ile Phe Glu Ser Asn Asn 
            580                 585                 590         


Ser Thr Ala Val Phe Asp Glu Asp Gln Asp Gln Asn Gln Asp Leu Ser 
        595                 600                 605             


Pro Tyr His Leu Asn Leu Asn Ser Lys Lys Val Leu Asp Pro Thr Phe 
    610                 615                 620                 


Glu Ser Arg Thr Arg Gln Val Thr Trp Asn Lys Asn Gly Lys Arg Ile 
625                 630                 635                 640 


Asp Arg Arg Leu Ser Ala Pro Glu Gln Gln Gln Gln Leu Glu Val Pro 
                645                 650                 655     


Pro Leu Lys Lys Ser Arg Arg Ser Val Gly Asn Ala Arg Val Ala Ser 
            660                 665                 670         


Gln Thr Asn Ser Asp Tyr Asn Ser Leu Gly Glu Ser Ser Thr Ser Ser 
        675                 680                 685             


Ala Pro Ser Ser Pro Ser Leu Lys Ala Ser Ser Gly Leu Ala Tyr Thr 
    690                 695                 700                 


Ala Asp Tyr Pro Asn Ala Thr Ser Pro Asp Phe Ala Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Asn Val Lys Pro Lys Ala Lys Ser Lys Ala Lys Gln Ser Ser Lys 
                725                 730                 735     


Lys Arg Pro Asn Asn Thr Thr Ser Lys Ser Lys Ala Asn Asn Ser Gln 
            740                 745                 750         


Glu Ser Asn Asn Ala Thr Ser Ser Thr Ser Gln Gly Thr Arg Ser Arg 
        755                 760                 765             


Thr Gly Cys Trp Ile Cys Arg Leu Arg Lys Lys Lys Cys Thr Glu Glu 
    770                 775                 780                 


Arg Pro His Cys Phe Asn Cys Glu Arg Leu Lys Leu Asp Cys His Tyr 
785                 790                 795                 800 


Asp Ala Phe Lys Pro Asp Phe Val Ser Asp Pro Lys Lys Lys Gln Met 
                805                 810                 815     


Lys Leu Glu Glu Ile Lys Lys Lys Thr Lys Glu Ala Lys Arg Arg Ala 
            820                 825                 830         


Met Lys Lys Lys 
        835     


<210>  5
<211>  2870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified SEC27 Nucleotide Sequence

<400>  5
atgaagttgg atataaaggt atgttaccag agcgcgtttt gccaatgcaa ttgcgaacaa       60

gctccgacaa ctcctatgat taggaaatga tctcgttcgc gaagaataca aagcctgcaa      120

aaagcaaaca ttaagattag ttactaacag gaagattttt gaaataaatg catttgctct      180

tggcatttcc tttatttgac actgtacatt tatgatagaa aacttttagt aatagatccg      240

atcgagttaa aggtatcgat ttccatccta ctgagccatg ggttttgact accttgtact      300

ctggtcgtgt tgagctttgg aattacgaaa cacaagttga agttagatcc atccaagtta      360

cggaaactcc tgttagagca ggtaaattca ttgcaagaaa gaattggata attgttggga      420

gtgatgattt caggatcaga gtcttcaact acaatacagg tgaaaaagtt gttgatttcg      480

aagctcatcc agactatatc cgttccattg ctgtacatcc aacaaagcct tatgttttat      540

ccggcagtga tgatttgaca gtcaaactat ggaattggga aaataactgg gccttagaac      600

aaacttttga aggtcacgaa cactttgtca tgtgcgtcgc attcaatcca aaggatccta      660

gtacgtttgc atctgggtgt ttggaccgaa ccgttaaagt ttggtcattg ggacaatcga      720

caccaaattt cacgttaacc acaggacaag aaagaggtgt gaattatgtt gattattacc      780

cgctacctga caagccttat atgattactg cgtcggacga cttaaccatc aaaatttggg      840

attaccaaac gaagtcatgt gtagccactc tagaaggtca catgtccaat gtttcttttg      900

ctgttttcca tccaacttta cccattataa tttctggttc cgaagatggc actttaaaga      960

tatggaattc ttccacttac aaggtagaaa agactttaaa cgttggttta gaaagaagtt     1020

ggtgtatcgc tacccatcca acaggacgta aaaactacat tgcatccggg tttgataatg     1080

ggtttaccgt actttccttg ggaaatgatg aaccaacttt atcacttgac cctgtcggta     1140

agctagtatg gtcaggtggc aaaaatgccg cagcttcaga cattttcact gccgtcataa     1200

gaggtaacga agaagttgaa caagatgaac cattatcttt acaaactaag gagctgggtt     1260

ccgttgatgt tttccctcaa tctttagccc attctccaaa tggtaggttt gttacagttg     1320

ttggggatgg tgaatacgtt atttatacgg cgttggcttg gagaaacaaa gccttcggta     1380

aatgtcaaga ctttgtttgg ggccccgact ccaatagtta tgctttaatt gatgaaactg     1440

ggcaaattaa atactacaaa aactttaaag aagtcacatc atggtctgtc ccaatgcatt     1500

ctgctattga tagattattt tcaggtgcct tgttgggtgt gaagtctgat ggcttcgtct     1560

atttcttcga ttgggacaac ggtacgctag ttagaagaat tgatgttaat gctaaggatg     1620

tcatttggtc cgataacggt gagctggtga tgattgtcaa caccaatagt aatggtgatg     1680

aagcaagtgg ttacacatta ttattcaaca aggatgctta ccttgaagca gcaaataatg     1740

gcaatatcga cgattcagaa ggtgttgatg aggcttttga cgtattgtat gaactaagtg     1800

aatccattac atcaggcaaa tgggttggtg atgtctttat ctttaccaca gcaactaaca     1860

ggctgaacta cttcgtaggt ggaaagactt ataatttagc ccattacaca aaggaaatgt     1920

atctattggg ctatctagca cgtgataata aagtatattt agctgacaga gaggtccatg     1980

tttatggtta cgaaatatct ctagaggtgc tggagttcca aacattgact ttaagagggg     2040

aaattgaaga agccattgaa aatgtactcc caaatgttga gggtaaggac tctttaacaa     2100

aaattgctag atttctggaa ggtcaagagt attatgaaga agcactgaat atttcccctg     2160

atcaagatca aaaatttgag ctagccttaa aagtcggcca acttacgctt gctcgcgatt     2220

tgttgacaga tgaaagcgcc gaaatgaaat ggagagcctt gggtgatgct tccttacaaa     2280

ggttcaattt taaacttgct gttgaagctt tcacaaatgc acatgatcta gaatctttat     2340

ttctattgca ctcatctttt aataacaagg aggggttggt cactttagct aaagatgctg     2400

aaagggccgg taaattcaat ttggctttta atgcatattg gatcgctggc gatatacaag     2460

gcgctaaaga tcttttaatc aagtctcaaa ggttttccga agccgctttc cttggatcaa     2520

catacggttt aggagatgat gcagtcaacg atattgttac aaaatggaag gaaaatttga     2580

tactcaacgg taagaatact gtatcagaaa gagtttgtgg ggccgaaggt ttaccaggct     2640

cttcgagttc aggagatgcc caaccactca ttgacttaga ttccactcca gccccagaac     2700

aagctgacga aaacaaagaa gctgaagttg aggacagcga gtttaaagaa tccaactcag     2760

aggcagttga agccgaaaaa aaagaagagg aagctcccca gcaacaacaa tcagaacaac     2820

agccggagca aggagaggca gtgccggagc ctgtggaaga agagagttaa                2870


<210>  6
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Sec27p Polypeptide Sequence

<400>  6

Met Lys Leu Asp Ile Lys Lys Thr Phe Ser Asn Arg Ser Asp Arg Val 
1               5                   10                  15      


Lys Gly Ile Asp Phe His Pro Thr Glu Pro Trp Val Leu Thr Thr Leu 
            20                  25                  30          


Tyr Ser Gly Arg Val Glu Leu Trp Asn Tyr Glu Thr Gln Val Glu Val 
        35                  40                  45              


Arg Ser Ile Gln Val Thr Glu Thr Pro Val Arg Ala Gly Lys Phe Ile 
    50                  55                  60                  


Ala Arg Lys Asn Trp Ile Ile Val Gly Ser Asp Asp Phe Arg Ile Arg 
65                  70                  75                  80  


Val Phe Asn Tyr Asn Thr Gly Glu Lys Val Val Asp Phe Glu Ala His 
                85                  90                  95      


Pro Asp Tyr Ile Arg Ser Ile Ala Val His Pro Thr Lys Pro Tyr Val 
            100                 105                 110         


Leu Ser Gly Ser Asp Asp Leu Thr Val Lys Leu Trp Asn Trp Glu Asn 
        115                 120                 125             


Asn Trp Ala Leu Glu Gln Thr Phe Glu Gly His Glu His Phe Val Met 
    130                 135                 140                 


Cys Val Ala Phe Asn Pro Lys Asp Pro Ser Thr Phe Ala Ser Gly Cys 
145                 150                 155                 160 


Leu Asp Arg Thr Val Lys Val Trp Ser Leu Gly Gln Ser Thr Pro Asn 
                165                 170                 175     


Phe Thr Leu Thr Thr Gly Gln Glu Arg Gly Val Asn Tyr Val Asp Tyr 
            180                 185                 190         


Tyr Pro Leu Pro Asp Lys Pro Tyr Met Ile Thr Ala Ser Asp Asp Leu 
        195                 200                 205             


Thr Ile Lys Ile Trp Asp Tyr Gln Thr Lys Ser Cys Val Ala Thr Leu 
    210                 215                 220                 


Glu Gly His Met Ser Asn Val Ser Phe Ala Val Phe His Pro Thr Leu 
225                 230                 235                 240 


Pro Ile Ile Ile Ser Gly Ser Glu Asp Gly Thr Leu Lys Ile Trp Asn 
                245                 250                 255     


Ser Ser Thr Tyr Lys Val Glu Lys Thr Leu Asn Val Gly Leu Glu Arg 
            260                 265                 270         


Ser Trp Cys Ile Ala Thr His Pro Thr Gly Arg Lys Asn Tyr Ile Ala 
        275                 280                 285             


Ser Gly Phe Asp Asn Gly Phe Thr Val Leu Ser Leu Gly Asn Asp Glu 
    290                 295                 300                 


Pro Thr Leu Ser Leu Asp Pro Val Gly Lys Leu Val Trp Ser Gly Gly 
305                 310                 315                 320 


Lys Asn Ala Ala Ala Ser Asp Ile Phe Thr Ala Val Ile Arg Gly Asn 
                325                 330                 335     


Glu Glu Val Glu Gln Asp Glu Pro Leu Ser Leu Gln Thr Lys Glu Leu 
            340                 345                 350         


Gly Ser Val Asp Val Phe Pro Gln Ser Leu Ala His Ser Pro Asn Gly 
        355                 360                 365             


Arg Phe Val Thr Val Val Gly Asp Gly Glu Tyr Val Ile Tyr Thr Ala 
    370                 375                 380                 


Leu Ala Trp Arg Asn Lys Ala Phe Gly Lys Cys Gln Asp Phe Val Trp 
385                 390                 395                 400 


Gly Pro Asp Ser Asn Ser Tyr Ala Leu Ile Asp Glu Thr Gly Gln Ile 
                405                 410                 415     


Lys Tyr Tyr Lys Asn Phe Lys Glu Val Thr Ser Trp Ser Val Pro Met 
            420                 425                 430         


His Ser Ala Ile Asp Arg Leu Phe Ser Gly Ala Leu Leu Gly Val Lys 
        435                 440                 445             


Ser Asp Gly Phe Val Tyr Phe Phe Asp Trp Asp Asn Gly Thr Leu Val 
    450                 455                 460                 


Arg Arg Ile Asp Val Asn Ala Lys Asp Val Ile Trp Ser Asp Asn Gly 
465                 470                 475                 480 


Glu Leu Val Met Ile Val Asn Thr Asn Ser Asn Gly Asp Glu Ala Ser 
                485                 490                 495     


Gly Tyr Thr Leu Leu Phe Asn Lys Asp Ala Tyr Leu Glu Ala Ala Asn 
            500                 505                 510         


Asn Gly Asn Ile Asp Asp Ser Glu Gly Val Asp Glu Ala Phe Asp Val 
        515                 520                 525             


Leu Tyr Glu Leu Ser Glu Ser Ile Thr Ser Gly Lys Trp Val Gly Asp 
    530                 535                 540                 


Val Phe Ile Phe Thr Thr Ala Thr Asn Arg Leu Asn Tyr Phe Val Gly 
545                 550                 555                 560 


Gly Lys Thr Tyr Asn Leu Ala His Tyr Thr Lys Glu Met Tyr Leu Leu 
                565                 570                 575     


Gly Tyr Leu Ala Arg Asp Asn Lys Val Tyr Leu Ala Asp Arg Glu Val 
            580                 585                 590         


His Val Tyr Gly Tyr Glu Ile Ser Leu Glu Val Leu Glu Phe Gln Thr 
        595                 600                 605             


Leu Thr Leu Arg Gly Glu Ile Glu Glu Ala Ile Glu Asn Val Leu Pro 
    610                 615                 620                 


Asn Val Glu Gly Lys Asp Ser Leu Thr Lys Ile Ala Arg Phe Leu Glu 
625                 630                 635                 640 


Gly Gln Glu Tyr Tyr Glu Glu Ala Leu Asn Ile Ser Pro Asp Gln Asp 
                645                 650                 655     


Gln Lys Phe Glu Leu Ala Leu Lys Val Gly Gln Leu Thr Leu Ala Arg 
            660                 665                 670         


Asp Leu Leu Thr Asp Glu Ser Ala Glu Met Lys Trp Arg Ala Leu Gly 
        675                 680                 685             


Asp Ala Ser Leu Gln Arg Phe Asn Phe Lys Leu Ala Val Glu Ala Phe 
    690                 695                 700                 


Thr Asn Ala His Asp Leu Glu Ser Leu Phe Leu Leu His Ser Ser Phe 
705                 710                 715                 720 


Asn Asn Lys Glu Gly Leu Val Thr Leu Ala Lys Asp Ala Glu Arg Ala 
                725                 730                 735     


Gly Lys Phe Asn Leu Ala Phe Asn Ala Tyr Trp Ile Ala Gly Asp Ile 
            740                 745                 750         


Gln Gly Ala Lys Asp Leu Leu Ile Lys Ser Gln Arg Phe Ser Glu Ala 
        755                 760                 765             


Ala Phe Leu Gly Ser Thr Tyr Gly Leu Gly Asp Asp Ala Val Asn Asp 
    770                 775                 780                 


Ile Val Thr Lys Trp Lys Glu Asn Leu Ile Leu Asn Gly Lys Asn Thr 
785                 790                 795                 800 


Val Ser Glu Arg Val Cys Gly Ala Glu Gly Leu Pro Gly Ser Ser Ser 
                805                 810                 815     


Ser Gly Asp Ala Gln Pro Leu Ile Asp Leu Asp Ser Thr Pro Ala Pro 
            820                 825                 830         


Glu Gln Ala Asp Glu Asn Lys Glu Ala Glu Val Glu Asp Ser Glu Phe 
        835                 840                 845             


Lys Glu Ser Asn Ser Glu Ala Val Glu Ala Glu Lys Lys Glu Glu Glu 
    850                 855                 860                 


Ala Pro Gln Gln Gln Gln Ser Glu Gln Gln Pro Glu Gln Gly Glu Ala 
865                 870                 875                 880 


Val Pro Glu Pro Val Glu Glu Glu Ser 
                885                 


<210>  7
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified ZRT1 Nucleotide Sequence

<400>  7
atgagcaacg ttactacgcc gtggtggaaa caatgggacc cttctgaagt tacacttgcc       60

gataaaaccc ctgatgatgt gtggaagacc tgtgttttgc aaggtgttta ctttggtgga      120

aacgagtaca atggtaactt aggtgccaga atatcttccg tctttgttat tcttttcgtg      180

agtacttttt tcaccatgtt cccattaatc tcaacaaaag tgaaaagatt gagaattcct      240

ctatatgttt accttttcgc aaagtatttt ggttccggtg ttattgttgc aaccgcattt      300

atccacttaa tggaccctgc ttatggtgcg attggtggta ccacttgtgt aggacaaacc      360

ggtaactggg gtctttattc atggtgtcct gccattatgc taacgagttt gaccttcact      420

ttccttactg atctattcag tagcgtctgg gttgaaagaa agtatggtct ttcccatgac      480

catacccacg atgaaattaa agacactgtt gtgagaaaca ctgcagctgt ttcaagtgag      540

aatgacaatg agaatggtac tgcaaatgga tctcatgaca ccaagaacgg agtagagtat      600

tatgaagatt cagacgctac atccatggat gttgttcaat catttcaagc acaattttat      660

gcctttttaa ttttagaatt cggtgtgatt ttccactccg ttatgatcgg tctaaacctg      720

ggaagtgttg gtgatgagtt ctcctcccta taccctgtct tagtgttcca tcaatcattt      780

gaaggtttag gtattggtgc aagattgtca gccattgaat tccctagatc aaagagatgg      840

tggccatggg ccctatgtgt tgcgtatggg ttaaccacac caatctgtgt ggccatcggt      900

ttgggtgttc gtaccagata cgtcagcggt tcttacactg cgcttgttat ctctggtgtt      960

ttggatgcca tttctgctgg tatcttattg tacactggtt tggttgaact actagcaaga     1020

gactttatat tcaatcctca aagaacaaag gatctaagag aattgtcctt caacgttata     1080

tgcactcttt tcggtgctgg tatcatggct ttgatcggta agtgggctta a              1131


<210>  8
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Zrt1p Polypeptide Sequence

<400>  8

Met Ser Asn Val Thr Thr Pro Trp Trp Lys Gln Trp Asp Pro Ser Glu 
1               5                   10                  15      


Val Thr Leu Ala Asp Lys Thr Pro Asp Asp Val Trp Lys Thr Cys Val 
            20                  25                  30          


Leu Gln Gly Val Tyr Phe Gly Gly Asn Glu Tyr Asn Gly Asn Leu Gly 
        35                  40                  45              


Ala Arg Ile Ser Ser Val Phe Val Ile Leu Phe Val Ser Thr Phe Phe 
    50                  55                  60                  


Thr Met Phe Pro Leu Ile Ser Thr Lys Val Lys Arg Leu Arg Ile Pro 
65                  70                  75                  80  


Leu Tyr Val Tyr Leu Phe Ala Lys Tyr Phe Gly Ser Gly Val Ile Val 
                85                  90                  95      


Ala Thr Ala Phe Ile His Leu Met Asp Pro Ala Tyr Gly Ala Ile Gly 
            100                 105                 110         


Gly Thr Thr Cys Val Gly Gln Thr Gly Asn Trp Gly Leu Tyr Ser Trp 
        115                 120                 125             


Cys Pro Ala Ile Met Leu Thr Ser Leu Thr Phe Thr Phe Leu Thr Asp 
    130                 135                 140                 


Leu Phe Ser Ser Val Trp Val Glu Arg Lys Tyr Gly Leu Ser His Asp 
145                 150                 155                 160 


His Thr His Asp Glu Ile Lys Asp Thr Val Val Arg Asn Thr Ala Ala 
                165                 170                 175     


Val Ser Ser Glu Asn Asp Asn Glu Asn Gly Thr Ala Asn Gly Ser His 
            180                 185                 190         


Asp Thr Lys Asn Gly Val Glu Tyr Tyr Glu Asp Ser Asp Ala Thr Ser 
        195                 200                 205             


Met Asp Val Val Gln Ser Phe Gln Ala Gln Phe Tyr Ala Phe Leu Ile 
    210                 215                 220                 


Leu Glu Phe Gly Val Ile Phe His Ser Val Met Ile Gly Leu Asn Leu 
225                 230                 235                 240 


Gly Ser Val Gly Asp Glu Phe Ser Ser Leu Tyr Pro Val Leu Val Phe 
                245                 250                 255     


His Gln Ser Phe Glu Gly Leu Gly Ile Gly Ala Arg Leu Ser Ala Ile 
            260                 265                 270         


Glu Phe Pro Arg Ser Lys Arg Trp Trp Pro Trp Ala Leu Cys Val Ala 
        275                 280                 285             


Tyr Gly Leu Thr Thr Pro Ile Cys Val Ala Ile Gly Leu Gly Val Arg 
    290                 295                 300                 


Thr Arg Tyr Val Ser Gly Ser Tyr Thr Ala Leu Val Ile Ser Gly Val 
305                 310                 315                 320 


Leu Asp Ala Ile Ser Ala Gly Ile Leu Leu Tyr Thr Gly Leu Val Glu 
                325                 330                 335     


Leu Leu Ala Arg Asp Phe Ile Phe Asn Pro Gln Arg Thr Lys Asp Leu 
            340                 345                 350         


Arg Glu Leu Ser Phe Asn Val Ile Cys Thr Leu Phe Gly Ala Gly Ile 
        355                 360                 365             


Met Ala Leu Ile Gly Lys Trp Ala 
    370                 375     


<210>  9
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified YLL056C Nucleotide Sequence

<400>  9
atgaaagtat ttataactgg tgcttctggc ttcattggtt ctgccgtatt atctgaacta       60

atatcctcgg gtcatgaagt tgttggcttg gcaaggtcag acgaggctgc tgcaaagatt      120

aagtcgattg atcctgctgc aaaaatcctt cgcggtgatc tcaaggatct ggaaattttg      180

aaaaaaggtg ccactgaatc tgatggcgtt attcatttag gatttgtgca tgattttaaa      240

aattttgaac agtgctgcga aattgaccgt caggccactg tagctatgct agagtcactt      300

aaaggttcta acaagccttt cttatatacg aatggtacac tttctttgcg accaaacaaa      360

gttgctaacg aacaggatgg tattgatgaa gattccaaaa ttttgcgtgc tgtcactgaa      420

caggttgcct tgagttacaa agacaaaggt gtttcagcaa gaattgtcag actcccattc      480

tcggttcatg gcaaggggga caaggctttt gtaccaatat taatgaatat tgccaaagct      540

gccggaaaat ctggctatgt cggacaaggc acaaacgctt gggcggctgt acatcgtttg      600

gatacggctc ctctgttcag acttgtttta gagaaaggaa aaacaggaca agtgtatcat      660

tgcgttggtg aacaaggtat accattcaaa gatattgcgc gtgtgattgg agaaattttg      720

aatgttcccg tggcctctat ccctgttgat gacgcggaaa gtcattttgg cttcctcact      780

tgttttgtca ctagagatgg cccagtttca agcgaaggta ccagaaaaga gctgggatgg      840

cagccacaac aaatcggtct tcttgaagat atccgtgcga actatagctt aaactga         897


<210>  10
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified YLL056c Polypeptide Sequence

<400>  10

Met Lys Val Phe Ile Thr Gly Ala Ser Gly Phe Ile Gly Ser Ala Val 
1               5                   10                  15      


Leu Ser Glu Leu Ile Ser Ser Gly His Glu Val Val Gly Leu Ala Arg 
            20                  25                  30          


Ser Asp Glu Ala Ala Ala Lys Ile Lys Ser Ile Asp Pro Ala Ala Lys 
        35                  40                  45              


Ile Leu Arg Gly Asp Leu Lys Asp Leu Glu Ile Leu Lys Lys Gly Ala 
    50                  55                  60                  


Thr Glu Ser Asp Gly Val Ile His Leu Gly Phe Val His Asp Phe Lys 
65                  70                  75                  80  


Asn Phe Glu Gln Cys Cys Glu Ile Asp Arg Gln Ala Thr Val Ala Met 
                85                  90                  95      


Leu Glu Ser Leu Lys Gly Ser Asn Lys Pro Phe Leu Tyr Thr Asn Gly 
            100                 105                 110         


Thr Leu Ser Leu Arg Pro Asn Lys Val Ala Asn Glu Gln Asp Gly Ile 
        115                 120                 125             


Asp Glu Asp Ser Lys Ile Leu Arg Ala Val Thr Glu Gln Val Ala Leu 
    130                 135                 140                 


Ser Tyr Lys Asp Lys Gly Val Ser Ala Arg Ile Val Arg Leu Pro Phe 
145                 150                 155                 160 


Ser Val His Gly Lys Gly Asp Lys Ala Phe Val Pro Ile Leu Met Asn 
                165                 170                 175     


Ile Ala Lys Ala Ala Gly Lys Ser Gly Tyr Val Gly Gln Gly Thr Asn 
            180                 185                 190         


Ala Trp Ala Ala Val His Arg Leu Asp Thr Ala Pro Leu Phe Arg Leu 
        195                 200                 205             


Val Leu Glu Lys Gly Lys Thr Gly Gln Val Tyr His Cys Val Gly Glu 
    210                 215                 220                 


Gln Gly Ile Pro Phe Lys Asp Ile Ala Arg Val Ile Gly Glu Ile Leu 
225                 230                 235                 240 


Asn Val Pro Val Ala Ser Ile Pro Val Asp Asp Ala Glu Ser His Phe 
                245                 250                 255     


Gly Phe Leu Thr Cys Phe Val Thr Arg Asp Gly Pro Val Ser Ser Glu 
            260                 265                 270         


Gly Thr Arg Lys Glu Leu Gly Trp Gln Pro Gln Gln Ile Gly Leu Leu 
        275                 280                 285             


Glu Asp Ile Arg Ala Asn Tyr Ser Leu Asn 
    290                 295             


<210>  11
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified YOL014W Nucleotide Sequence

<400>  11
atgcgaccac atcatttttt ttgtggtaac atgggagtga tgtatacggc catgtctgga       60

tacgaaacag aagacgcaca agcctactgg gcatgcggta gagcatatga atcagctttt      120

gcaacgttga ctaaaaaggt tccaggaacc acattctcag ctgatatgcc aacatctact      180

tggcatggtg tcctggattg cggctattcc tcttcaatta acgtggcaga aaataaaagt      240

tcgcccatcg attattggaa ttgtggtaga acatatgcca ggaattatgc tctgtccgat      300

gcgctttcac tgaagccaac gaatatgtta cagtactttc tattagtatt attttttatc      360

tgcattatac tatga                                                       375


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified YOL014w Polypeptide Sequence

<400>  12

Met Arg Pro His His Phe Phe Cys Gly Asn Met Gly Val Met Tyr Thr 
1               5                   10                  15      


Ala Met Ser Gly Tyr Glu Thr Glu Asp Ala Gln Ala Tyr Trp Ala Cys 
            20                  25                  30          


Gly Arg Ala Tyr Glu Ser Ala Phe Ala Thr Leu Thr Lys Lys Val Pro 
        35                  40                  45              


Gly Thr Thr Phe Ser Ala Asp Met Pro Thr Ser Thr Trp His Gly Val 
    50                  55                  60                  


Leu Asp Cys Gly Tyr Ser Ser Ser Ile Asn Val Ala Glu Asn Lys Ser 
65                  70                  75                  80  


Ser Pro Ile Asp Tyr Trp Asn Cys Gly Arg Thr Tyr Ala Arg Asn Tyr 
                85                  90                  95      


Ala Leu Ser Asp Ala Leu Ser Leu Lys Pro Thr Asn Met Leu Gln Tyr 
            100                 105                 110         


Phe Leu Leu Val Leu Phe Phe Ile Cys Ile Ile Leu 
        115                 120                 


<210>  13
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified MTH1 Nucleotide Sequence

<400>  13
atgtttgttt caccaccacc agcaacttcg aaaaaccaag ttttacaacg acgtccatta       60

gaatcgacta acagtaatca tgggtttgca agctccctac aggccattcc ggaaaacacg      120

atgagtggca gtgataatgc ttcttttcaa agtttgccac tatcaatgag tagctctcaa      180

tccacgactt cttcgagaag agagaacttt gtgaatgctc ctccggagta cactgataga      240

gctagagatg agattaaaaa aagattattg gcctcctcac ctagcagaag gtcacatcat      300

tcaagcagta tgcattcagc gagcaggaga tcaagcgtgg ctgaaagtgg gagtttactt      360

tcggataatg cctcgtctta tcaatcaagt atattttctg ccccctctac tgtgcacacg      420

caactaacta atgactcttc gttctccgaa tttcctaacc acaagttaat cacgagagtg      480

agcctggatg aagcattacc caaaacgttt tatgacatgt attcgccaga tattctatta      540

gcagacccat ccaacattct ctgtaacggg cgtcccaagt ttaccaagag agagttattg      600

gattgggatt taaacgatat aagatcgtta ttgatagtcg agaagttaag gcccgaatgg      660

ggtaatcaac taccggaagt aataacggtg ggtgataata tgccccagtt taggttacaa      720

ttattaccac tatattctag cgatgagacc ataatcgcaa cgttagtcca ttcggatctg      780

tacatggagg ctaacttaga ttatgaattc aaactaacca gcgccaaata tacagtagcg      840

accgctagaa aaagacatga gcatataact ggtagaaatg aagccgtcat gaatttgtcg      900

aaaccggaat ggagaaatat catcgaaaat tacctcttaa atatagcagt agaggcacaa      960

tgcaggtttg atttcaaaca aagatgctcc gaatataaga aatggaagtt acaacagtcc     1020

aacttaaaaa gaccggacat gcccccacca agcataatac cgcggaaaaa cagcacagaa     1080

acaaaatcgc ttctgaaaaa ggctttattg aagaacattc agttgaaaaa ccccaataat     1140

aaccttgatg aattgatgat gagatcaagc gccgcaacaa atcaacaggg aaaaaacaaa     1200

gtcagcttat ctaaagaaga aaaggctacg atatggtcgc aatgtcaggc acaagtttac     1260

caaagattag gattggattg gcagccggat tcagtatcct ga                        1302


<210>  14
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Mth1p Polypeptide Sequence

<400>  14

Met Phe Val Ser Pro Pro Pro Ala Thr Ser Lys Asn Gln Val Leu Gln 
1               5                   10                  15      


Arg Arg Pro Leu Glu Ser Thr Asn Ser Asn His Gly Phe Ala Ser Ser 
            20                  25                  30          


Leu Gln Ala Ile Pro Glu Asn Thr Met Ser Gly Ser Asp Asn Ala Ser 
        35                  40                  45              


Phe Gln Ser Leu Pro Leu Ser Met Ser Ser Ser Gln Ser Thr Thr Ser 
    50                  55                  60                  


Ser Arg Arg Glu Asn Phe Val Asn Ala Pro Pro Glu Tyr Thr Asp Arg 
65                  70                  75                  80  


Ala Arg Asp Glu Ile Lys Lys Arg Leu Leu Ala Ser Ser Pro Ser Arg 
                85                  90                  95      


Arg Ser His His Ser Ser Ser Met His Ser Ala Ser Arg Arg Ser Ser 
            100                 105                 110         


Val Ala Glu Ser Gly Ser Leu Leu Ser Asp Asn Ala Ser Ser Tyr Gln 
        115                 120                 125             


Ser Ser Ile Phe Ser Ala Pro Ser Thr Val His Thr Gln Leu Thr Asn 
    130                 135                 140                 


Asp Ser Ser Phe Ser Glu Phe Pro Asn His Lys Leu Ile Thr Arg Val 
145                 150                 155                 160 


Ser Leu Asp Glu Ala Leu Pro Lys Thr Phe Tyr Asp Met Tyr Ser Pro 
                165                 170                 175     


Asp Ile Leu Leu Ala Asp Pro Ser Asn Ile Leu Cys Asn Gly Arg Pro 
            180                 185                 190         


Lys Phe Thr Lys Arg Glu Leu Leu Asp Trp Asp Leu Asn Asp Ile Arg 
        195                 200                 205             


Ser Leu Leu Ile Val Glu Lys Leu Arg Pro Glu Trp Gly Asn Gln Leu 
    210                 215                 220                 


Pro Glu Val Ile Thr Val Gly Asp Asn Met Pro Gln Phe Arg Leu Gln 
225                 230                 235                 240 


Leu Leu Pro Leu Tyr Ser Ser Asp Glu Thr Ile Ile Ala Thr Leu Val 
                245                 250                 255     


His Ser Asp Leu Tyr Met Glu Ala Asn Leu Asp Tyr Glu Phe Lys Leu 
            260                 265                 270         


Thr Ser Ala Lys Tyr Thr Val Ala Thr Ala Arg Lys Arg His Glu His 
        275                 280                 285             


Ile Thr Gly Arg Asn Glu Ala Val Met Asn Leu Ser Lys Pro Glu Trp 
    290                 295                 300                 


Arg Asn Ile Ile Glu Asn Tyr Leu Leu Asn Ile Ala Val Glu Ala Gln 
305                 310                 315                 320 


Cys Arg Phe Asp Phe Lys Gln Arg Cys Ser Glu Tyr Lys Lys Trp Lys 
                325                 330                 335     


Leu Gln Gln Ser Asn Leu Lys Arg Pro Asp Met Pro Pro Pro Ser Ile 
            340                 345                 350         


Ile Pro Arg Lys Asn Ser Thr Glu Thr Lys Ser Leu Leu Lys Lys Ala 
        355                 360                 365             


Leu Leu Lys Asn Ile Gln Leu Lys Asn Pro Asn Asn Asn Leu Asp Glu 
    370                 375                 380                 


Leu Met Met Arg Ser Ser Ala Ala Thr Asn Gln Gln Gly Lys Asn Lys 
385                 390                 395                 400 


Val Ser Leu Ser Lys Glu Glu Lys Ala Thr Ile Trp Ser Gln Cys Gln 
                405                 410                 415     


Ala Gln Val Tyr Gln Arg Leu Gly Leu Asp Trp Gln Pro Asp Ser Val 
            420                 425                 430         


Ser 
    


<210>  15
<211>  491
<212>  PRT
<213>  Torulaspora delbrueckii

<400>  15

Met Ala Ala Val Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly 
1               5                   10                  15      


Gln Asn Leu Ile Leu Asn Val Ala Asp His Gly Phe Thr Val Val Ala 
            20                  25                  30          


Tyr Asn Arg Thr Thr Ser Lys Val Asp His Phe Leu Glu Asn Glu Ala 
        35                  40                  45              


Lys Gly Lys Ser Ile Val Gly Ala His Ser Leu Glu Glu Leu Val Ser 
    50                  55                  60                  


Lys Leu Lys Lys Pro Arg Lys Ile Met Leu Leu Val Lys Ala Gly Lys 
65                  70                  75                  80  


Pro Val Asp Tyr Leu Ile Asn Asp Leu Val Pro Leu Leu Asp Lys Gly 
                85                  90                  95      


Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg 
            100                 105                 110         


Arg Phe Glu Glu Leu Glu Lys Lys Gly Ile Leu Phe Val Gly Ser Gly 
        115                 120                 125             


Val Ser Gly Gly Glu Asp Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro 
    130                 135                 140                 


Gly Gly Ala Glu Glu Ala Trp Pro His Ile Lys Pro Ile Phe Gln Ala 
145                 150                 155                 160 


Ile Ser Ala Lys Ser Asp Gly Glu Ala Cys Cys Asp Trp Val Gly Pro 
                165                 170                 175     


Ala Gly Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         


Gly Asp Met Gln Leu Ile Cys Glu Val Tyr Asp Ile Leu Lys Arg Val 
        195                 200                 205             


Gly Gly Phe Glu Asp Lys Glu Ile Ser Glu Val Phe Ala Lys Trp Asn 
    210                 215                 220                 


Thr Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Thr Asp Gly Val Pro Ile Val Glu Lys Ile Leu Asp 
                245                 250                 255     


Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu 
            260                 265                 270         


Asp Leu Gly Gln Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ser Arg 
        275                 280                 285             


Cys Leu Ser Ala Leu Lys Ala Glu Arg Gly Arg Ala Ser Lys Val Leu 
    290                 295                 300                 


Pro Gly Pro Glu Ile Pro Lys Asn Ala Ile Thr Asp Lys Lys Gln Phe 
305                 310                 315                 320 


Val Asp Asp Leu Glu Gln Ala Leu Tyr Ala Ala Lys Ile Ile Ser Tyr 
                325                 330                 335     


Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Gly Lys Thr Tyr Gly Trp 
            340                 345                 350         


Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile 
        355                 360                 365             


Ile Arg Ser Ala Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Gln Asn 
    370                 375                 380                 


Pro Glu Leu Glu Asn Leu Leu Phe His Ser Phe Phe Ser Asp Ala Val 
385                 390                 395                 400 


Ser Lys Ala Gln Ser Gly Trp Arg Lys Thr Ala Ala Leu Ala Thr Gln 
                405                 410                 415     


Tyr Gly Ile Pro Thr Pro Ala Ile Ser Thr Ala Leu Ala Phe Tyr Asp 
            420                 425                 430         


Gly Tyr Arg Cys Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg 
        435                 440                 445             


Asp Tyr Phe Gly Ala His Cys Phe Lys Val Leu Pro Glu Phe Ala Ser 
    450                 455                 460                 


Ala Thr Phe Pro Glu Gly Lys Asp Ile His Val Asn Trp Thr Gly His 
465                 470                 475                 480 


Gly Gly Asn Ile Ser Ala Ser Ser Tyr Asp Ala 
                485                 490     


<210>  16
<211>  497
<212>  PRT
<213>  Vanderwaltozyma polyspora


<220>
<221>  misc_feature
<222>  (209)..(211)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Val Ala Asp His Gly Tyr Thr Val Cys Ala Phe Asn 
            20                  25                  30          


Arg Thr Val Ala Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Gln Asp Phe Val Ser Lys Ile 
    50                  55                  60                  


Lys Arg Pro Arg Lys Ile Met Met Leu Val Lys Ala Gly Gln Pro Val 
65                  70                  75                  80  


Asp Asp Leu Ile Asp Glu Leu Leu Pro His Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Tyr Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Asp Tyr Leu Thr Lys Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Ala Ala Trp Pro Glu Ile Lys Glu Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ala Asp Gly Glu Pro Cys Cys Asp Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Leu Met Lys Arg Val Gly Gly 
        195                 200                 205             


Xaa Xaa Xaa Glu Arg Val Gly Gly Leu Thr Asp Lys Glu Cys Ser Asp 
    210                 215                 220                 


Val Phe Gly Thr Trp Asn Lys Gly Val Leu Asn Ser Phe Leu Ile Glu 
225                 230                 235                 240 


Ile Thr Thr Asp Ile Leu Lys Tyr Asn Asp Thr Asp Gly Val Pro Leu 
                245                 250                 255     


Val Glu Lys Ile Leu Asp Gln Ala Gly Gln Lys Gly Thr Gly Lys Trp 
            260                 265                 270         


Thr Ala Ile Asn Ala Leu Asp Leu Ala Met Pro Val Thr Leu Ile Gly 
        275                 280                 285             


Glu Ala Val Phe Ser Arg Cys Leu Ser Ala Ile Lys Asp Gln Arg Val 
    290                 295                 300                 


Gln Ala Ser Gly Ile Leu Pro Gly Pro Ser Val Pro Lys Gly Ala Ile 
305                 310                 315                 320 


Lys Asp Arg Lys Gln Phe Ile Asp Asp Leu Glu Gln Ala Leu Tyr Ala 
                325                 330                 335     


Ser Lys Ile Ile Ser Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala 
            340                 345                 350         


Gly Ile Gln Tyr Gly Trp Lys Leu Asn Asn Pro Ser Ile Ala Leu Met 
        355                 360                 365             


Trp Arg Gly Gly Cys Ile Ile Arg Ser Val Phe Leu Gly Glu Ile Thr 
    370                 375                 380                 


Lys Ala Tyr Arg Gln Asn Gly Asp Leu Val Asn Leu Leu Phe Asp Lys 
385                 390                 395                 400 


Phe Phe Thr Asp Ala Val Thr Lys Ala Gln Asp Gly Trp Arg Lys Thr 
                405                 410                 415     


Ile Ser Leu Ser Ala Leu Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr 
            420                 425                 430         


Ala Leu Ala Phe Tyr Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn 
        435                 440                 445             


Leu Leu Gln Ala Gln Arg Asp Tyr Phe Gly Ala His Thr Phe Lys Val 
    450                 455                 460                 


Cys Pro Lys Tyr Ala Ser Asp Lys Met Pro Leu Asp Thr Pro Ile His 
465                 470                 475                 480 


Val Asn Trp Thr Gly Lys Gly Gly Asn Val Ser Ala Ser Thr Tyr Asn 
                485                 490                 495     


Ala 
    


<210>  17
<211>  492
<212>  PRT
<213>  Kluyveromyces lactis

<400>  17

Met Ser Glu Pro Ala Gly Asp Ile Gly Leu Ile Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Val Ser Lys Val Asp His Phe Leu Ala Asn Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala His Ser Val Glu Glu Leu Cys 
    50                  55                  60                  


Arg Asn Leu Lys Arg Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly 
65                  70                  75                  80  


Asp Ala Val Asp Ala Phe Ile Gln Gln Leu Leu Pro Phe Leu Glu Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn 
            100                 105                 110         


Arg Arg Tyr Asp Glu Leu Lys Glu Lys Gly Ile Tyr Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ala Glu Glu Ala Trp Pro His Ile Lys Asp Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ser Ala Lys Ser Asp Gly Glu Pro Cys Cys Asp Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Thr Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Ile Gly Gly Phe Thr Asp Lys Glu Ile Gly Glu Val Phe Ser Gln Trp 
    210                 215                 220                 


Asn Lys Gly Val Leu Asp Ser Phe Leu Val Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Leu Tyr Asp Asp Val Asp Gly Thr Pro Leu Val Glu Lys Ile Leu 
                245                 250                 255     


Asp Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ser Leu Lys Asp Glu Arg Val Arg Ala Ser Lys Leu 
    290                 295                 300                 


Leu Pro Gly Pro Gln Ile Pro Lys Asp Ala Val Lys Glu Arg Gln Gln 
305                 310                 315                 320 


Phe Val Asp Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Gly Lys Thr Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Glu 
    370                 375                 380                 


Asn Pro Glu Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala 
385                 390                 395                 400 


Val Glu Lys Ala Gln Ser Gly Trp Arg Lys Thr Ile Gly Leu Ala Val 
                405                 410                 415     


Ser Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ser Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Ala Ala 
    450                 455                 460                 


Ser Glu Asn Leu Pro Ala Asp Gln Asn Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


Lys Gly Gly Asn Val Ser Ala Ser Ser Tyr Gln Ala 
                485                 490         


<210>  18
<211>  489
<212>  PRT
<213>  Candida glabrata

<400>  18

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ile Ala Asp His Gly Tyr Thr Val Val Ala Tyr Asn 
            20                  25                  30          


Arg Ser Val Asp Lys Val His Gln Phe Leu Asp Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Glu Ser Ile Glu Asp Leu Val Ala Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Ile Met Met Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Gly Leu Ile Ala Gln Leu Val Pro His Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Asp Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ala Glu Glu Ala Trp Pro His Ile Lys Glu Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Asp Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Ile Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Gly Lys Trp Asp Thr Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Val Glu Ile Thr Thr Asn Ile Leu Lys Lys 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Ser Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Ser Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Cys Glu Arg Val Lys Ala Ser Lys Thr Leu Pro Gly 
    290                 295                 300                 


Pro Glu Ile Pro Lys Asp Leu Ile Lys Asp Arg Gln Gln Phe Ile Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Ala Lys Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Glu Asn Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe His Lys Phe Phe Lys Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Gly Gly Trp Arg Arg Ser Leu Ala Leu Ala Ala Thr Tyr Gly 
                405                 410                 415     


Ile Pro Ser Pro Ala Phe Ala Thr Ala Leu Ser Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Ser 
    450                 455                 460                 


Leu Pro Lys Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Thr Thr Tyr Asp Ala 
                485                 


<210>  19
<211>  489
<212>  PRT
<213>  Zygosaccharomyces rouxii

<400>  19

Met Ser Ala Asp Phe Gly Leu Val Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Val Val Asp His Gly Phe Ser Ala Val Val Tyr Asn 
            20                  25                  30          


Arg Thr Thr Ser Arg Val Asp Glu Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Asn Ile Gln Gly Ala His Ser Ile Lys Glu Phe Val Asp Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Leu Met Leu Leu Val Lys Ala Gly Lys Pro Val 
65                  70                  75                  80  


Asp Tyr Leu Ile Gly Asp Leu Leu Pro Tyr Leu Glu Glu Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Thr Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Gln Lys Gly Ile His Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Asp Gly Ala Arg Trp Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Asp Glu Ala Ala Trp Pro Ala Ile Lys Ser Ile Phe Gln Ser Val Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Asp Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Val Tyr Asp Ile Leu Lys Arg Val Gly Lys 
        195                 200                 205             


Phe Glu Asp Lys Glu Ile Gly Glu Ile Phe Glu Lys Trp Asn Lys Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Thr Asp Ile Leu Lys Lys 
225                 230                 235                 240 


Asn Asp Lys Asp Gly Val Pro Leu Val Glu Lys Ile Leu Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Val Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Gln Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ser Arg Cys Leu 
        275                 280                 285             


Ser Ala Ile Lys Pro Glu Arg Thr Arg Ala Ser Lys Ile Leu Pro Gly 
    290                 295                 300                 


Pro Glu Ile Pro Asp Gly Val Val Lys Asp Lys Lys Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Gly Lys Glu Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Ala Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Gln Asp Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe His Asp Phe Phe Thr Gln Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Gly Gly Trp Arg Arg Ile Leu Gly Ile Ser Thr Thr Tyr Gly 
                405                 410                 415     


Val Pro Thr Pro Ala Leu Ala Thr Ala Leu Ala Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Ala Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Gln Val Leu Pro Glu Cys Ala Asn Ala Asp 
    450                 455                 460                 


Phe Pro Ala Gly Gln Asp Ile His Phe Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Ile Ser Ser Ser Ser Tyr Gln Ala 
                485                 


<210>  20
<211>  489
<212>  PRT
<213>  Saccharomyces castellii

<400>  20

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Val Ser Lys Val Glu His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Val Gly Ala Thr Ser Ile Asp Asp Phe Leu Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Asn Glu Leu Val Pro Arg Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Thr Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Gln Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Asp Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ala Glu Glu Ala Trp Pro His Ile Lys Asp Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Asp Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Val Gly His 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Gly Asp Val Phe Glu Thr Trp Asn Lys Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asn Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Ile Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ser Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Ser Glu Arg Ile Arg Ala Ser Lys Thr Leu Leu Gly 
    290                 295                 300                 


Pro Glu Val Pro Lys Asp Leu Ile Lys Asp Lys Lys Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Met Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Gly Lys Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Glu Asp Pro Glu 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ser Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Thr Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Asn 
    450                 455                 460                 


Leu Pro Leu Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  21
<211>  489
<212>  PRT
<213>  Tetrapisispora blattae

<400>  21

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Thr Ser Lys Val Asp Ala Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Val Gly Ala His Ser Leu Gln Glu Leu Val Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Arg Val Met Leu Leu Val Lys Ala Gly Gly Ala Val 
65                  70                  75                  80  


Asp Thr Thr Ile Asp Ser Leu Val Pro Phe Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Ala Leu Lys Glu Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Asn Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ala Glu Glu Ala Trp Pro Tyr Ile Lys Asp Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ala Asp Gly Glu Pro Cys Cys Asp Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Val Gly Gly 
        195                 200                 205             


Phe Thr Asn Lys Glu Ile Ala Asp Val Phe Ala Thr Trp Asn Lys Gly 
    210                 215                 220                 


Val Leu Asp Ser Tyr Leu Ile Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Leu Asp Ser Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Met Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ser Leu Lys Ser Glu Arg Thr Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Thr Val Pro Lys Asp Ala Val Lys Asn Lys Gln Glu Phe Ile Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Thr Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Gly Lys Asn Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ser Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Glu Ile Thr Lys Ala Tyr Arg Gln Asn Pro Glu 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Gly Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Thr Val Ala Leu Gly Ala Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Lys Ile Leu Pro Glu Ala Ala Ser Glu Ser 
    450                 455                 460                 


Leu Pro Glu Gly Lys Asn Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ala Ser Thr Tyr Asp Ala 
                485                 


<210>  22
<211>  489
<212>  PRT
<213>  Saccharomyces bayanus

<400>  22

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Gln Ser Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Gln Asp Phe Ile Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Lys Glu Ile Val Pro Leu Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Lys His Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Asp Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Leu Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Thr Thr Trp Asn Lys Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Asn Glu Arg Val Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Gln Val Pro Lys Asp Ala Val Lys Asp Arg Lys Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Ala Ala Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Gln Glu Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Thr Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Glu Asn 
    450                 455                 460                 


Leu Pro Glu Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  23
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Gnd1p L340W

<400>  23

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Gln Ser Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Phe Ile Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Asn Gln Ile Val Pro Leu Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Lys Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Leu Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Asp Val Phe Ala Lys Trp Asn Asn Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Val Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Asn Glu Arg Ile Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Glu Val Pro Lys Asp Ala Val Lys Asp Arg Glu Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Trp Ile Arg Glu Ala Ala Ala Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Gln Ile Thr Lys Ala Tyr Arg Glu Glu Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ser Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Asn 
    450                 455                 460                 


Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  24
<211>  1479
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  24
atgtcaaagg cagtaggtga tttaggctta gttggtttag ccgtgatggg tcaaaatttg       60

atcttaaacg cagcggatca cggatttacc gtggttgctt ataataggac gcaatcaaag      120

gtagataggt ttctagctaa tgaggcaaaa ggaaaatcaa taattggtgc aacttcaatt      180

gaggacttgg ttgcgaaact aaagaaacct agaaagatta tgcttttaat caaagccggt      240

gctccggtcg acactttaat aaaggaactt gtaccacatc ttgataaagg cgacattatt      300

atcgacggtg gtaactcaca tttcccggac actaacagac gctacgaaga gctaacaaag      360

caaggaattc tttttgtggg ctctggtgtc tcaggcggtg aagatggtgc acgttttggt      420

ccatctttaa tgcctggtgg gtcagcagaa gcatggccgc acatcaagaa catctttcaa      480

tctattgccg ccaaatcaaa cggtgagcca tgctgcgaat gggtggggcc tgccggttct      540

ggtcactatg tgaagatggt acacaacggt atcgagtacg gtgatatgca gttgatttgc      600

gaggcttacg atatcatgaa acgaattggc cggtttacgg ataaagagat cagtgaagta      660

tttgacaagt ggaacactgg agttttggat tctttcttga ttgaaatcac gagggacatt      720

ttaaaattcg atgacgtcga cggtaagcca ttggtggaaa aaattatgga tactgccggt      780

caaaagggta ctggtaaatg gactgcaatc aacgccttgg atttaggaat gccagtcact      840

ttaattgggg aggctgtttt cgctcgttgt ttgtcagcca taaaggacga acgtaaaaga      900

gcttcgaaac ttctggcagg accaacagta ccaaaggatg caatacatga tagagaacaa      960

tttgtgtatg atttggaaca agcattatac gcttcaaaga ttatttcata tgctcaaggt     1020

ttcatgctga tccgcgaagc tgccagatca tacggctgga aattaaacaa cccagctatt     1080

gctctaatgt ggagaggtgg ctgtataatc agatctgtgt tcttagctga gattacgaag     1140

gcttataggg acgatccaga tttggaaaat ttattattca acgagttctt cgcttctgca     1200

gttactaagg cccaatccgg ttggagaaga actattgccc ttgctgctac ttacggtatt     1260

ccaactccag ctttctctac tgctttagcg ttttacgacg gctatagatc tgagaggcta     1320

ccagcaaact tgttacaagc gcaacgtgat tattttggcg ctcatacatt tagaatttta     1380

cctgaatgtg cttctgccca tttgccagta gacaaggata ttcatatcaa ttggactggg     1440

cacggaggta atatatcttc ctcaacctac caagcttaa                            1479


<210>  25
<211>  492
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Ser Lys Ala Val Gly Asp Leu Gly Leu Val Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Gln Ser Lys Val Asp Arg Phe Leu Ala Asn Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Leu Val 
    50                  55                  60                  


Ala Lys Leu Lys Lys Pro Arg Lys Ile Met Leu Leu Ile Lys Ala Gly 
65                  70                  75                  80  


Ala Pro Val Asp Thr Leu Ile Lys Glu Leu Val Pro His Leu Asp Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Thr Asn 
            100                 105                 110         


Arg Arg Tyr Glu Glu Leu Thr Lys Gln Gly Ile Leu Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Asp Gly Ala Arg Phe Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ser Ala Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ala Ala Lys Ser Asn Gly Glu Pro Cys Cys Glu Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Ile Gly Arg Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Asp Lys Trp 
    210                 215                 220                 


Asn Thr Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Lys Phe Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met 
                245                 250                 255     


Asp Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ala Ile Lys Asp Glu Arg Lys Arg Ala Ser Lys Leu 
    290                 295                 300                 


Leu Ala Gly Pro Thr Val Pro Lys Asp Ala Ile His Asp Arg Glu Gln 
305                 310                 315                 320 


Phe Val Tyr Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Ala Arg Ser Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Asp 
    370                 375                 380                 


Asp Pro Asp Leu Glu Asn Leu Leu Phe Asn Glu Phe Phe Ala Ser Ala 
385                 390                 395                 400 


Val Thr Lys Ala Gln Ser Gly Trp Arg Arg Thr Ile Ala Leu Ala Ala 
                405                 410                 415     


Thr Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Ile Leu Pro Glu Cys Ala 
    450                 455                 460                 


Ser Ala His Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


His Gly Gly Asn Ile Ser Ser Ser Thr Tyr Gln Ala 
                485                 490         


<210>  26
<211>  492
<212>  PRT
<213>  Saccharomyces bayanus

<400>  26

Met Ser Lys Ala Val Gly Asp Leu Gly Leu Val Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Gln Ser Lys Val Asp Arg Phe Leu Ala Asn Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Leu Val 
    50                  55                  60                  


Ala Lys Leu Lys Arg Pro Arg Lys Ile Met Leu Leu Ile Lys Ala Gly 
65                  70                  75                  80  


Ala Pro Val Asp Ile Leu Ile Lys Glu Leu Val Pro His Leu Asp Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn 
            100                 105                 110         


Arg Arg Tyr Glu Glu Leu Thr Lys Gln Gly Ile Leu Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Glu Gly Ala Arg Phe Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ser Lys Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ala Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Leu Gly Gly Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Thr Lys Trp 
    210                 215                 220                 


Asn Thr Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Lys Phe Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met 
                245                 250                 255     


Asp Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ala Leu Lys Asn Glu Arg Leu Arg Ala Ser Lys Val 
    290                 295                 300                 


Leu Pro Gly Pro Glu Ile Pro Lys Asp Ala Val Lys Asp Arg Gln Gln 
305                 310                 315                 320 


Phe Val Asp Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Ala Ala Thr Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Asp 
    370                 375                 380                 


Asp Ala Asp Leu Glu Asn Leu Leu Phe Asn Asp Phe Phe Ala Ser Ala 
385                 390                 395                 400 


Ala Thr Lys Ala Gln Ser Gly Trp Arg Arg Ser Ile Ala Leu Ala Ala 
                405                 410                 415     


Thr Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala 
    450                 455                 460                 


Ser Ala Asn Leu Pro Val Asp Arg Asp Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


His Gly Gly Asn Ile Ser Ser Ser Thr Tyr Gln Ala 
                485                 490         


<210>  27
<211>  492
<212>  PRT
<213>  Saccharomyces kudriavzevii

<400>  27

Met Ser Lys Ala Val Gly Asp Leu Gly Leu Ile Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Gln Ser Lys Val Asp Arg Phe Leu Ala Asp Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala Thr Ser Ile Arg Asp Leu Val 
    50                  55                  60                  


Ala Lys Leu Lys Lys Pro Arg Lys Ile Met Ile Leu Ile Lys Ala Gly 
65                  70                  75                  80  


Ala Pro Val Asp Asn Leu Ile Lys Glu Leu Val Pro His Leu Asp Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn 
            100                 105                 110         


Arg His Tyr Glu Glu Leu Thr Arg Gln Gly Ile Leu Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Asp Gly Ala Arg Phe Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ser Glu Glu Ala Trp Pro His Ile Lys Asp Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ala Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Ile Gly Arg Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Glu Lys Trp 
    210                 215                 220                 


Asn Asn Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Lys Phe Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met 
                245                 250                 255     


Asp Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ala Ile Lys Asp Glu Arg Lys Arg Ala Ser Lys Leu 
    290                 295                 300                 


Leu Ala Gly Pro Thr Val Pro Lys Asp Ala Ile Asp Asp Arg Gln Gln 
305                 310                 315                 320 


Phe Val Cys Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Leu Ile Arg Glu Ala Ala Arg Ser Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Asn 
    370                 375                 380                 


Asp Pro Asp Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Ser Ala 
385                 390                 395                 400 


Ala Thr Lys Ala Gln Ser Gly Trp Arg Arg Ser Ile Ala Leu Ala Ala 
                405                 410                 415     


Thr Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Ile Leu Pro Glu Cys Ser 
    450                 455                 460                 


Ser Ala His Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


His Gly Gly Asn Ile Ser Ser Ser Thr Tyr Gln Ala 
                485                 490         


<210>  28
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Gnd2p L343W

<400>  28

Met Ser Lys Ala Val Gly Asp Leu Gly Leu Val Gly Leu Ala Val Met 
1               5                   10                  15      


Gly Gln Asn Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Val 
            20                  25                  30          


Ala Tyr Asn Arg Thr Gln Ser Lys Val Asp Arg Phe Leu Ala Asn Glu 
        35                  40                  45              


Ala Lys Gly Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Leu Val 
    50                  55                  60                  


Ala Lys Leu Lys Lys Pro Arg Lys Ile Met Leu Leu Ile Lys Ala Gly 
65                  70                  75                  80  


Ala Pro Val Asp Thr Leu Ile Lys Glu Leu Val Pro His Leu Asp Lys 
                85                  90                  95      


Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Thr Asn 
            100                 105                 110         


Arg Arg Tyr Glu Glu Leu Thr Lys Gln Gly Ile Leu Phe Val Gly Ser 
        115                 120                 125             


Gly Val Ser Gly Gly Glu Asp Gly Ala Arg Phe Gly Pro Ser Leu Met 
    130                 135                 140                 


Pro Gly Gly Ser Ala Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln 
145                 150                 155                 160 


Ser Ile Ala Ala Lys Ser Asn Gly Glu Pro Cys Cys Glu Trp Val Gly 
                165                 170                 175     


Pro Ala Gly Ser Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu 
            180                 185                 190         


Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg 
        195                 200                 205             


Ile Gly Arg Phe Thr Asp Lys Glu Ile Ser Glu Val Phe Asp Lys Trp 
    210                 215                 220                 


Asn Thr Gly Val Leu Asp Ser Phe Leu Ile Glu Ile Thr Arg Asp Ile 
225                 230                 235                 240 


Leu Lys Phe Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met 
                245                 250                 255     


Asp Thr Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala 
            260                 265                 270         


Leu Asp Leu Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala 
        275                 280                 285             


Arg Cys Leu Ser Ala Ile Lys Asp Glu Arg Lys Arg Ala Ser Lys Leu 
    290                 295                 300                 


Leu Ala Gly Pro Thr Val Pro Lys Asp Ala Ile His Asp Arg Glu Gln 
305                 310                 315                 320 


Phe Val Tyr Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser 
                325                 330                 335     


Tyr Ala Gln Gly Phe Met Trp Ile Arg Glu Ala Ala Arg Ser Tyr Gly 
            340                 345                 350         


Trp Lys Leu Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys 
        355                 360                 365             


Ile Ile Arg Ser Val Phe Leu Ala Glu Ile Thr Lys Ala Tyr Arg Asp 
    370                 375                 380                 


Asp Pro Asp Leu Glu Asn Leu Leu Phe Asn Glu Phe Phe Ala Ser Ala 
385                 390                 395                 400 


Val Thr Lys Ala Gln Ser Gly Trp Arg Arg Thr Ile Ala Leu Ala Ala 
                405                 410                 415     


Thr Tyr Gly Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ala Phe Tyr 
            420                 425                 430         


Asp Gly Tyr Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln 
        435                 440                 445             


Arg Asp Tyr Phe Gly Ala His Thr Phe Arg Ile Leu Pro Glu Cys Ala 
    450                 455                 460                 


Ser Ala His Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly 
465                 470                 475                 480 


His Gly Gly Asn Ile Ser Ser Ser Thr Tyr Gln Ala 
                485                 490         


