
                                SEQUENCE LISTING

<110> Rodriguez, Moses
      Warrington, Arthur E.
      Pease, Larry R.

<120> Human Antibodies and Specific Binding Sequences Thereof
	For Use In Stroke And Ischemia Or Ischemic Conditions

<130> 1199-1-016PCT3

<140> Unassigned          
<141> 2013-04-17  

<150> 61/625,628          
<151> 2012-04-17  
 

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 118
<212> PRT
<213> Homo sapiens

<400> 1
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Leu Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Glu Pro Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Ser Ser Gly Ser Thr Asp Tyr Asn Pro Ser Leu Arg
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Asn Asn Arg Phe Ser Leu
65                  70                  75                  80  
Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Trp Cys Ala
                85                  90                  95      
Arg Ser Ala Ser Ile Arg Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 2
<211> 354
<212> DNA
<213> Homo sapiens

<400> 2
caggtgcagc tgcaggagtc gggcccagga ctgctgaagc cttcggagac cctgtccctc 60
acatgcactg tctctggtgg ttccgtcagt ctttactact ggagctggat ccggcagtcc 120
ccagggaagg aaccggagtg gattggatat atctattcca gtggaagcac cgattacaac 180
ccttccctca ggagtcgagt caccatatca ctggacacgt caaacaaccg gttttcccta 240
aacctgaggt ctgtgaccgc cgcagataca gcggtctatt ggtgtgcgag aagtgcgtca 300
attaggggct ggttcgaccc ctggggccag ggaaccctgg tcaccgtctc ctca       354

<210> 3
<211> 104
<212> PRT
<213> Homo sapiens

<400> 3
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn
 1               5                  10                  15      
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp
            20                  25                  30          
Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser
        35                  40                  45              
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys
    50                  55                  60                  
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln
65                  70                  75                  80  
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn
                85                  90                  95      
Lys Glu Lys Asn Val Pro Leu Pro
            100                 


<210> 4
<211> 310
<212> DNA
<213> Homo sapiens

<400> 4
gagtgcatcc gccccaaccc ttttccccct cgtctcctgt gagaattccc cgtcggatac 60
gagcagcgtg gccgttggct gcctcgcaca ggacttcctt cccgactcca tcactttctc 120
ctggaaatac aagaacaact ctgacatcag cagcacccgg ggcttcccat cagtcctgag 180
agggggcaag tacgcagcca cctcacaggt gctgctgcct tccaaggacg tcatgcaggg 240
cacagacgaa cacgtggtgt gcaaagtcca gcaccccaac ggcaacaaag aaaagaacgt 300
gcctcttcca                                                        310

<210> 5
<211> 112
<212> PRT
<213> Homo sapiens

<400> 5
Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg
 1               5                  10                  15      
Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala
            20                  25                  30          
Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly
        35                  40                  45              
Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala
    50                  55                  60                  
Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile
65                  70                  75                  80  
Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr Cys Arg Val Asp
                85                  90                  95      
His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro
            100                 105                 110         


<210> 6
<211> 336
<212> DNA
<213> Homo sapiens

<400> 6
gtgattgctg agctgcctcc caaagtgagc gtcttcgtcc caccccgcga cggcttcttc 60
ggcaaccccc gcaagtccaa gctcatctgc caggccacgg gtttcagtcc ccggcagatt 120
caggtgtcct ggctgcgcga ggggaagcag gtggggtctg gcgtcaccac ggaccaggtg 180
caggctgagg ccaaagagtc tgggcccacg acctacaagg tgaccagcac actgaccatc 240
aaagagagcg actggctcag ccagagcatg ttcacctgcc gcgtggatca caggggcctg 300
accttccagc agaatgcgtc ctccatgtgt gtcccc                           336

<210> 7
<211> 106
<212> PRT
<213> Homo sapiens

<400> 7
Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala
 1               5                  10                  15      
Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp
            20                  25                  30          
Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly
        35                  40                  45              
Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala
    50                  55                  60                  
Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn
65                  70                  75                  80  
Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser
                85                  90                  95      
Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys
            100                 105     


<210> 8
<211> 318
<212> DNA
<213> Homo sapiens

<400> 8
gatcaagaca cagccatccg ggtcttcgcc atccccccat cctttgccag catcttcctc 60
accaagtcca ccaagttgac ctgcctggtc acagacctga ccacctatga cagcgtgacc 120
atctcctgga cccgccagaa tggcgaagct gtgaaaaccc acaccaacat ctccgagagc 180
caccccaatg ccactttcag cgccgtgggt gaggccagca tctgcgagga tgactggaat 240
tccggggaga ggttcacgtg caccgtgacc cacacagacc tgccctcgcc actgaagcag 300
accatctccc ggcccaag                                               318

<210> 9
<211> 131
<212> PRT
<213> Homo sapiens

<400> 9
Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg
 1               5                  10                  15      
Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr
            20                  25                  30          
Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln
        35                  40                  45              
Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro
    50                  55                  60                  
Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu
65                  70                  75                  80  
Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu
                85                  90                  95      
Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly
            100                 105                 110         
Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly
        115                 120                 125             
Thr Cys Tyr
    130     


<210> 10
<211> 392
<212> DNA
<213> Homop sapiens

<400> 10
gggtggccct gcacaggccc gatgtctact tgctgccacc agcccgggag cagctgaacc 60
tgcgggagtc ggccaccatc acgtgcctgg tgacgggctt ctctcccgcg gacgtcttcg 120
tgcagtggat gcagaggggg cagcccttgt ccccggagaa gtatgtgacc agcgccccaa 180
tgcctgagcc ccaggcccca ggccggtact tcgcccacag catcctgacc gtgtccgaag 240
aggaatggaa cacgggggag acctacacct gcgtggtggc ccatgaggcc ctgcccaaca 300
gggtcaccga gaggaccgtg gacaagtcca ccggtaaacc caccctgtac aacgtgtccc 360
tggtcatgtc cgacacagct ggcacctgct ac                               392

<210> 11
<211> 105
<212> PRT
<213> Homo sapiens

<400> 11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Val Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr His Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu
            100                 105 


<210> 12
<211> 315
<212> DNA
<213> Homo sapiens

<400> 12
gacatccaga tgacccagtc tccatcctcc ttgtctgcgt ctgtaggaga cagagtcacc 60
atcacttgcc gggcaagtca gagtattagt agttatctaa attggtatca gcagaaacca 120
gggaaagccc ctaaggtcct gatctatgct gcatccactt tgcgaagtgg ggtcccgtca 180
aggttcagtg gcagtggatc tgggacagat ttcactctca gcgtcagcag tctgcaacct 240
gaagattttg caacttacta ctgtcaacag agttaccata ccccgtggac gttcggtcag 300
gggaccaagg tggaa                                                  315

<210> 13
<211> 109
<212> PRT
<213> Homo sapiens

<400> 13
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
 1               5                  10                  15      
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
            20                  25                  30          
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
        35                  40                  45              
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
    50                  55                  60                  
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
65                  70                  75                  80  
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
                85                  90                  95      
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105                 


<210> 14
<211> 330
<212> DNA
<213> Homo sapiens

<400> 14
atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 60
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 120
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 180
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 240
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 300
acaaagagct tcaacagggg agagtgttag                                  330

<210> 15
<211> 159
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys
 1               5                  10                  15      
Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp
            20                  25                  30          
Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser
        35                  40                  45              
Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val
    50                  55                  60                  
Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg
65                  70                  75                  80  
Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro
                85                  90                  95      
Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn
            100                 105                 110         
Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg
        115                 120                 125             
Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr
    130                 135                 140                 
Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp
145                 150                 155                 


<210> 16
<211> 480
<212> DNA
<213> Homo sapiens

<400> 16
atgaagaacc atttgctttt ctggggagtc ctggcggttt ttattaaggc tgttcatgtg 60
aaagcccaag aagatgaaag gattgttctt gttgacaaca aatgtaagtg tgcccggatt 120
acttccagga tcatccgttc ttccgaagat cctaatgagg acattgtgga gagaaacatc 180
cgaattattg ttcctctgaa caacagggag aatatctctg atcccacctc accattgaga 240
accagatttg tgtaccattt gtctgacctc tgtaaaaaat gtgatcctac agaagtggag 300
ctggataatc agatagttac tgctacccag agcaatatct gtgatgaaga cagtgctaca 360
gagacctgct acacttatga cagaaacaag tgctacacag ctgtggtccc actcgtatat 420
ggtggtgaga ccaaaatggt ggaaacagcc ttaaccccag atgcctgcta tcctgactaa 480


<210> 17
<211> 133
<212> PRT
<213> Homo sapiens

<400> 17
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
 1               5                  10                  15      
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val Ser
        35                  40                  45              
Asp Ile Asn Val Gly Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Met Tyr Tyr Cys Val
                85                  90                  95      
Arg Arg Ser Gly Pro Asp Arg Asn Ser Ser Pro Ala Asp Phe Trp Gly
            100                 105                 110         
Gln Gly Ser Leu Val Ile Val Ser Ser Gly Ser Ala Ser Ala Pro Thr
        115                 120                 125             
Leu Phe Pro Leu Val
    130             


<210> 18
<211> 402
<212> DNA
<213> Homo sapiens

<400> 18
gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc 60
tgtgcagcct ctggattcac ctttagcacc tatgccatga gctgggtccg ccaggctcca 120
ggggaggggc tggagtgggt ctcagatatt aatgttggtg gtgttaccac atactacgca 180
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatcta 240
caaatgaaca gcctgagagt agaggacacg gccatgtatt actgtgtgag gcggtccggg 300
cccgatcgca actcgtcgcc cgctgacttc tggggccagg gatccctggt catcgtctcc 360
tcagggagtg catccgcccc aacccttttc cccctcgtct ga                    402

<210> 19
<211> 104
<212> PRT
<213> Homo sapiens

<400> 19
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn
 1               5                  10                  15      
Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp
            20                  25                  30          
Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser
        35                  40                  45              
Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys
    50                  55                  60                  
Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln
65                  70                  75                  80  
Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn
                85                  90                  95      
Lys Glu Lys Asn Val Pro Leu Pro
            100                 


<210> 20
<211> 310
<212> DNA
<213> Homo sapiens

<400> 20
gagtgcatcc gccccaaccc ttttccccct cgtctcctgt gagaattccc cgtcggatac 60
gagcagcgtg gccgttggct gcctcgcaca ggacttcctt cccgactcca tcactttctc 120
ctggaaatac aagaacaact ctgacatcag cagcacccgg ggcttcccat cagtcctgag 180
agggggcaag tacgcagcca cctcacaggt gctgctgcct tccaaggacg tcatgcaggg 240
cacagacgaa cacgtggtgt gcaaagtcca gcaccccaac ggcaacaaag aaaagaacgt 300
gcctcttcca                                                        310

<210> 21
<211> 112
<212> PRT
<213> Homo sapiens

<400> 21
Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg
 1               5                  10                  15      
Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala
            20                  25                  30          
Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly
        35                  40                  45              
Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala
    50                  55                  60                  
Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile
65                  70                  75                  80  
Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr Cys Arg Val Asp
                85                  90                  95      
His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro
            100                 105                 110         


<210> 22
<211> 336
<212> DNA
<213> Homo sapiens

<400> 22
gtgattgctg agctgcctcc caaagtgagc gtcttcgtcc caccccgcga cggcttcttc 60
ggcaaccccc gcaagtccaa gctcatctgc caggccacgg gtttcagtcc ccggcagatt 120
caggtgtcct ggctgcgcga ggggaagcag gtggggtctg gcgtcaccac ggaccaggtg 180
caggctgagg ccaaagagtc tgggcccacg acctacaagg tgaccagcac actgaccatc 240
aaagagagcg actggctcag ccagagcatg ttcacctgcc gcgtggatca caggggcctg 300
accttccagc agaatgcgtc ctccatgtgt gtcccc                           336

<210> 23
<211> 106
<212> PRT
<213> Homo sapiens

<400> 23
Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala
 1               5                  10                  15      
Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp
            20                  25                  30          
Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly
        35                  40                  45              
Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala
    50                  55                  60                  
Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn
65                  70                  75                  80  
Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser
                85                  90                  95      
Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys
            100                 105     


<210> 24
<211> 318
<212> DNA
<213> Homo sapiens

<400> 24
gatcaagaca cagccatccg ggtcttcgcc atccccccat cctttgccag catcttcctc 60
accaagtcca ccaagttgac ctgcctggtc acagacctga ccacctatga cagcgtgacc 120
atctcctgga cccgccagaa tggcgaagct gtgaaaaccc acaccaacat ctccgagagc 180
caccccaatg ccactttcag cgccgtgggt gaggccagca tctgcgagga tgactggaat 240
tccggggaga ggttcacgtg caccgtgacc cacacagacc tgccctcgcc actgaagcag 300
accatctccc ggcccaag                                               318

<210> 25
<211> 131
<212> PRT
<213> Homo sapiens

<400> 25
Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg
 1               5                  10                  15      
Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr
            20                  25                  30          
Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln
        35                  40                  45              
Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro
    50                  55                  60                  
Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu
65                  70                  75                  80  
Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu
                85                  90                  95      
Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly
            100                 105                 110         
Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly
        115                 120                 125             
Thr Cys Tyr
    130     


<210> 26
<211> 392
<212> DNA
<213> Homo sapiens

<400> 26
gggtggccct gcacaggccc gatgtctact tgctgccacc agcccgggag cagctgaacc 60
tgcgggagtc ggccaccatc acgtgcctgg tgacgggctt ctctcccgcg gacgtcttcg 120
tgcagtggat gcagaggggg cagcccttgt ccccggagaa gtatgtgacc agcgccccaa 180
tgcctgagcc ccaggcccca ggccggtact tcgcccacag catcctgacc gtgtccgaag 240
aggaatggaa cacgggggag acctacacct gcgtggtggc ccatgaggcc ctgcccaaca 300
gggtcaccga gaggaccgtg gacaagtcca ccggtaaacc caccctgtac aacgtgtccc 360
tggtcatgtc cgacacagct ggcacctgct ac                               392

<210> 27
<211> 105
<212> PRT
<213> Homo sapiens

<400> 27
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Thr Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Arg
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Asp
            100                 105 


<210> 28
<211> 315
<212> DNA
<213> Homo sapiens

<400> 28
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc gggcgagtca gggcattggc aattatttag cctggtatca gcagaaacca 120
gggaaagttc ctaaactcct gatctatact acatccattt tgcaatcagg ggtcccatct 180
cgattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaaaaa tataacagtg ccccgcggac gttcggccaa 300
gggaccaggg tggac                                                  315

<210> 29
<211> 109
<212> PRT
<213> Homo sapiens

<400> 29
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
 1               5                  10                  15      
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
            20                  25                  30          
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
        35                  40                  45              
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
    50                  55                  60                  
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
65                  70                  75                  80  
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
                85                  90                  95      
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105                 


<210> 30
<211> 330
<212> DNA
<213> Homo sapiens

<400> 30
atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 60
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 120
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 180
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 240
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 300
acaaagagct tcaacagggg agagtgttag                                  330

<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR1

<400> 31
Gly Gly Ser Val Ser Leu Tyr Tyr
 1               5              


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR2

<400> 32
Gly Tyr Ile Tyr Ser Ser Gly Ser Thr
 1               5                  


<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR3

<400> 33
Ala Arg Ser Ala Ser Ile Arg Gly Trp Phe Asp
 1               5                  10      


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR1

<400> 34
Gln Ser Ile Ser Ser Tyr
 1               5      


<210> 35
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR2

<400> 35
Ala Ala Ser
 1          


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR3

<400> 36
Gln Gln Ser Tyr His Thr Pro Trp
 1               5              


<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR1

<400> 37
Gly Phe Thr Phe Ser Thr Tyr Ala
 1               5              


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR2

<400> 38
Ile Asn Val Gly Gly Val Thr Thr
 1               5              


<210> 39
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy Chain CDR3

<400> 39
Val Arg Arg Ser Gly Pro Asp Arg Asn Ser Ser Pro Ala Asp Phe
 1               5                  10                  15  


<210> 40
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR1

<400> 40
Gln Gly Ile Gly
 1              


<210> 41
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR2

<400> 41
Thr Thr Ser
 1          


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light Chain CDR3

<400> 42
Gln Lys Tyr Asn Ser Ala Pro Arg Thr
 1               5                  


<210> 43
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 50
<223> Xaa can be Val or Ile

<221> VARIANT        
<222> 89
<223> Xaa can be Asp or Glu

<400> 43
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Xaa Ile Ser Tyr Asp Gly Ser Arg Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Xaa Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Val Thr Gly Ser Pro Thr Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 44
<211> 114
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 46
<223> Xaa can be Arg or Lys

<221> VARIANT        
<222> 90
<223> Xaa can be Gly or Glu

<400> 44
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Xaa Leu Leu
        35                  40                  45              
Ile Tyr Asp Ile Thr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Xaa Thr Trp Asp Ser Ser Leu
                85                  90                  95      
Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110         
Pro Lys
        


<210> 45
<211> 124
<212> PRT
<213> Homo sapiens

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Met Val
        35                  40                  45              
Ala Asn Ile Lys Lys Asp Gly Ser Glu Lys Ser Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Pro Asn Cys Gly Gly Asp Cys Tyr Leu Pro Trp Tyr Phe Asp
            100                 105                 110         
Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 46
<211> 122
<212> PRT
<213> Homo sapiens

<400> 46
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Asn Thr Pro Gln Ala Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe
        115                 120         

