                         SEQUENCE LISTING

<110>  b3 bio
 
<120>  Compositions comprising an internalizing nucleic acid molecule 
       and their methods of use

<130>  b3bio101

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  1

Gly Pro Pro Gly Pro 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  2

Gly Glu Ala Gly Pro 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  3

Gly Glu Thr Gly Pro 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  4

Gly Glu Ser Gly Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  5

Gly Asp Thr Gly Pro 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  6

Gly Asp Ser Gly Pro 
1               5   


<210>  7
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  7

Pro Pro Gly Pro 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  8

Gly Phe Leu Gly 
1               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  9

Gly Phe Gln Gly Val Gln Phe Ala Gly Phe 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  10

Gly Phe Gly Ser Val Gln Phe Ala Gly Phe 
1               5                   10  


<210>  11
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  11

Ala Leu Ala Leu 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  12

Arg Val Arg Arg 
1               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  13

Ala Gly Asn Arg Val Arg Arg Ser Val Gly 
1               5                   10  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  14

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
1               5                   10          


<210>  15
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  15

Ser Asn Ser Arg Lys Lys Arg Ser Thr Ser Ala Gly Pro 
1               5                   10              


<210>  16
<211>  6
<212>  DNA
<213>  Artificial

<220>
<223>  synthesized; double stranded

<400>  16
agagga                                                                   6


<210>  17
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  synthesized

<400>  17
ataatccacc tatcccagta ggagaaat                                          28


<210>  18
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  synthesized

<400>  18
tttggtcctt gtcttatgtc cagaatgcta atacgactca ctatagggag gacgatgcgg       60


<210>  19
<211>  40
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized

<400>  19
uacuuucggg cuuucggcaa caucagcccc ucaggacgca                             40


<210>  20
<211>  40
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized

<400>  20
uccccggauu ucggauacga ucccucaucc cuugaccgca                             40


<210>  21
<211>  83
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  misc_RNA
<222>  (16)..(55)

<220>
<221>  misc_feature
<222>  (16)..(55)
<223>  n is a, c, g, or u

<400>  21
gggaggacga ugcggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnauuuc       60

uccuacuggg auagguggau uau                                               83


<210>  22
<211>  13
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  misc_RNA
<222>  (7)..(7)
<223>  N can be any of A, U, G, C ; and the number of N is one to 4.

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or u

<400>  22
uuucggnuuu cgg                                                          13


<210>  23
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized

<400>  23
cacgagaggu ccuccggaag c                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthesized

<400>  24
gcttccggag gacctctcgt g                                                 21


<210>  25
<211>  62
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(62)

<400>  25
gggaggacga ugcgguacuu ucgggcuuuc ggcaacauca gccccucagg acgcaauuuc       60

uc                                                                      62


<210>  26
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  26
gggugcggua cuuucgggcu uucggcaaca ucagccccuc aggacg                      46


<210>  27
<211>  32
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(32)

<400>  27
gggaggcuuu cgggcuuucg gcaacaucag cc                                     32


<210>  28
<211>  22
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(22)

<400>  28
gggaggcugg gcuuucggca ac                                                22


<210>  29
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  29
gggugcgaaa cuuucgggcu uucggcaaca ucagccccuc agaccg                      46


<210>  30
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  30
gggugcggua cuaaagggcu uucggcaaca ucagcccaaa aggacg                      46


<210>  31
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  31
gggugcggua cuuucgggcu aaaggcaaca ucagccccuc aggacg                      46


<210>  32
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  32
gggugcggua cuuucgggcu uucaaaaaca ucagccccuc aggacg                      46


<210>  33
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  33
gggugcggua cuuucgggcu uucggcuuua ucagccccuc aggacg                      46


<210>  34
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  34
gggugcggua cuuucgggcu uucggcccca ucagccccuc aggacg                      46


<210>  35
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  35
gggugcggua cuuucgggcu uucggcaacu auagccccuc aggacg                      46


<210>  36
<211>  46
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(46)

<400>  36
gggugcggua cuuucgggcu ggcacuuucg aaagccccuc aggacg                      46


<210>  37
<211>  70
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(70)

<400>  37
aagguacucu gugcuugucg augugyauug auggcacuuu cgagucaacg aguugacagg       60

acaaguaguc                                                              70


<210>  38
<211>  83
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(83)

<400>  38
gggaggacga ugcggucccc ggauuucgga uacgaucccu caucccuuga ccgcaauuuc       60

uccuacuggg auagguggau uau                                               83


<210>  39
<211>  83
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(83)

<400>  39
gggaggacga ugcgguacuu ucgggcuuuc ggcaacauca gccccucagg acgcaauuuc       60

uccuacuggg auagguggau uau                                               83


<210>  40
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized

<400>  40
cacgagaggu ccuccggaag c                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthesized

<400>  41
gcttccggag gacctctcgt g                                                 21


<210>  42
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  42

Arg Glu Asp Leu 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  43

Lys Asp Glu Leu 
1               


<210>  44
<211>  245
<212>  PRT
<213>  Artificial

<220>
<223>  synthesized

<400>  44

Met Lys Lys Lys Lys His His His His His His Ala Ser Gly Gly Arg 
1               5                   10                  15      


His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu Phe 
            20                  25                  30          


Leu Gly Asp Gly Gly Ala Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
        35                  40                  45              


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Gly 
    50                  55                  60                  


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
65                  70                  75                  80  


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
                85                  90                  95      


Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
            100                 105                 110         


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn Gly 
        115                 120                 125             


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
    130                 135                 140                 


Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
145                 150                 155                 160 


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
                165                 170                 175     


Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
            180                 185                 190         


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
        195                 200                 205             


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu Ala 
    210                 215                 220                 


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
225                 230                 235                 240 


Arg Glu Asp Leu Lys 
                245 


<210>  45
<211>  104
<212>  RNA
<213>  Artificial

<220>
<223>  synthesized


<220>
<221>  stem_loop
<222>  (1)..(104)

<400>  45
gggaggacga ugcgguacuu ucgggcuuuc ggcaacauca gccccucagg acgcaauuuc       60

uccuacuggg auagguggau uaucacgaga gguccuccgg aagc                       104


