                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
 
<120>  METHODS AND COMPOSITIONS FOR MANIPULATING THE IMMUNE RESPONSE

<130>  WST135PCT

<150>  61/636425
<151>  2012-04-20

<150>  61/637136
<151>  2012-04-23

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  7102
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (527)..(2560)

<400>  1
ggggggtggg cgccagcgcc ccggcgaacg gcaaagaggg agccgctccc gctcgggggg       60

ccgctggagt gcccagcggg aacccgaaag tttgtaagag gaagagagcg cgcggcgagc      120

gagcgagcgg gccgggggca gcggcagcgg cgccggggac catggtgctg ccggcgcctc      180

ctccgcgggc gtgaaggcgg cgctcctact ccctccccgg actccgcggt gtcccagaag      240

cttttgttga caattccagt ttccgaacaa aacatttcgg caatggtgag ggcttcgatc      300

ccttctctga tttgctgtca gccatgaacg gatggatgtg atgcctgcta gccaaaaggc      360

ttccctctgt gtgttgcagt cctgtggcat tatgcatgcc ccctcccagt gaccccaggc      420

tttttatggc tgtgagacac gttaaaattt caggggtaag acgtgacctt ttgaggtgac      480

tataactgaa gattgcttta cagaagccaa aaaaggtttt tgagtc atg atg caa         535
                                                   Met Met Gln            
                                                   1                      

gaa tct ggg act gag aca aaa agt aac ggt tca gcc atc cag aat ggg        583
Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile Gln Asn Gly           
    5                   10                  15                            

tcg ggc ggc agc aac cac tta cta gag tgc ggc ggt ctt cgg gag ggg        631
Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu Arg Glu Gly           
20                  25                  30                  35            

cgg tcc aac gga gag acg ccg gcc gtg gac atc ggg gca gct gac ctc        679
Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala Ala Asp Leu           
                40                  45                  50                

gcc cac gcc cag cag cag cag caa cag gca ctt cag gtg gca aga cag        727
Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln           
            55                  60                  65                    

ctc ctt ctt cag cag caa cag cag cag caa gtt agt gga tta aaa tct        775
Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly Leu Lys Ser           
        70                  75                  80                        

ccc aag agg aat gac aaa caa cca gct ctt cag gtt ccc gtg tca gtg        823
Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro Val Ser Val           
    85                  90                  95                            

gct atg atg aca cct caa gtt atc act ccc cag caa atg cag cag atc        871
Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile           
100                 105                 110                 115           

ctc cag caa caa gtg ctg agc cct cag cag ctc cag gtt ctc ctc cag        919
Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln           
                120                 125                 130               

cag cag cag gcc ctc atg ctt caa cag cag cag ctt caa gag ttt tat        967
Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr           
            135                 140                 145                   

aaa aaa caa cag gaa cag ttg cag ctt caa ctt tta caa caa caa cat       1015
Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His           
        150                 155                 160                       

gct gga aaa cag cct aaa gag caa cag cag gtg gct acc cag cag ttg       1063
Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu           
    165                 170                 175                           

gct ttt cag cag cag ctt tta cag atg cag cag tta cag cag cag cac       1111
Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His           
180                 185                 190                 195           

ctc ctg tct ttg cag cgc caa ggc ctt ctg aca att cag ccc ggg cag       1159
Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln           
                200                 205                 210               

cct gcc ctt ccc ctt caa cct ctt gct caa ggc atg att cca aca gaa       1207
Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu           
            215                 220                 225                   

ctg cag cag ctc tgg aaa gaa gtg aca agt gct cat act gca gaa gaa       1255
Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu           
        230                 235                 240                       

acc aca ggc aac aat cac agc agt ttg gat ctg acc acg aca tgt gtc       1303
Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val           
    245                 250                 255                           

tcc tcc tct gca cct tcc aag acc tcc tta ata atg aac cca cat gcc       1351
Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala           
260                 265                 270                 275           

tct acc aat gga cag ctc tca gtc cac act ccc aaa agg gaa agt ttg       1399
Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu           
                280                 285                 290               

tcc cat gag gag cac ccc cat agc cat cct ctc tat gga cat ggt gta       1447
Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val           
            295                 300                 305                   

tgc aag tgg cca ggc tgt gaa gca gtg tgc gaa gat ttc caa tca ttt       1495
Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe           
        310                 315                 320                       

cta aaa cat ctc aac agt gag cat gcg ctg gac gat aga agt aca gcc       1543
Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala           
    325                 330                 335                           

caa tgt aga gta caa atg cag gtt gta cag cag tta gag cta cag ctt       1591
Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu           
340                 345                 350                 355           

gca aaa gac aaa gaa cgc ctg caa gcc atg atg acc cac ctg cat gtg       1639
Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val           
                360                 365                 370               

aag tct aca gaa ccc aaa gcc gcc cct cag ccc ttg aat ctg gta tca       1687
Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser           
            375                 380                 385                   

agt gtc act ctc tcc aag tcc gca tcg gag gct tct cca cag agc tta       1735
Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu           
        390                 395                 400                       

cct cat act cca acg acc cca acc gcc ccc ctg act ccc gtc acc caa       1783
Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln           
    405                 410                 415                           

ggc ccc tct gtc atc aca acc acc agc atg cac acg gtg gga ccc atc       1831
Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile           
420                 425                 430                 435           

cgc agg cgg tac tca gac aaa tac aac gtg ccc att tcg tca gca gat       1879
Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp           
                440                 445                 450               

att gcg cag aac caa gaa ttt tat aag aac gca gaa gtt aga cca cca       1927
Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro           
            455                 460                 465                   

ttt aca tat gca tct tta att agg cag gcc att ctc gaa tct cca gaa       1975
Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu           
        470                 475                 480                       

aag cag cta aca cta aat gag atc tat aac tgg ttc aca cga atg ttt       2023
Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe           
    485                 490                 495                           

gct tac ttc cga cgc aac gcg gcc acg tgg aag aat gca gtg cgt cat       2071
Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His           
500                 505                 510                 515           

aat ctt agt ctt cac aag tgt ttt gtg cga gta gaa aac gtt aaa ggg       2119
Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly           
                520                 525                 530               

gca gta tgg aca gtg gat gaa gta gaa ttc caa aaa cga agg cca caa       2167
Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln           
            535                 540                 545                   

aag atc agt ggt aac cct tcc ctt att aaa aac atg cag agc agc cac       2215
Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His           
        550                 555                 560                       

gcc tac tgc aca cct ctc aat gca gct tta cag gct tca atg gct gag       2263
Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu           
    565                 570                 575                           

aat agt ata cct cta tac act acc gct tcc atg gga aat ccc act ctg       2311
Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu           
580                 585                 590                 595           

ggc aac tta gcc agc gca ata cgg gaa gag ctg aac ggg gca atg gag       2359
Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu           
                600                 605                 610               

cat acc aac agc aac gag agt gac agc agt cca ggc aga tct cct atg       2407
His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met           
            615                 620                 625                   

caa gcc gtg cat cct gta cac gtc aaa gaa gag ccc ctc gat cca gag       2455
Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu           
        630                 635                 640                       

gaa gct gaa ggg ccc ctg tcc tta gtg aca aca gcc aac cac agt cca       2503
Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro           
    645                 650                 655                           

gat ttt gac cat gac aga gat tac gaa gat gaa cca gta aac gag gac       2551
Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp           
660                 665                 670                 675           

atg gag tga ctatcggggc gggccaaccc cgagaatgaa gattggaaaa               2600
Met Glu                                                                   
                                                                          

aggaaaaaaa aaaaaacacg tcaaaagtta gcagtgaaat tgttctccat ttgttgtaca     2660

gtctggagga ttttcactac gttttgacaa ctctgaaatg tgttaactct tagtgccatc     2720

aagaacccca tttgggagta tttttgattt ttctactttt tgttgaaaaa aggaatttgt     2780

actctgtgca ttggatggac ttgtttggta cttgggattt tcctctctta accgtcaaca     2840

tcagtgttgt aaatttgcta aactgattca cttttagcag cagactttga actgcagtcc     2900

tgccaacgtt ggacactgag gacgcccgac agagcttgtg cacctaagct gcagaccaag     2960

cctttgccca gaatttaagg attccaatgg acgacctatt tgcacagtac tgcatgttga     3020

ttatcactgc ctttactcct tttttttttt tttttttttt tttttttttg cttccagttg     3080

ggatggggaa ggcctttgtg tgtgtattgg ggggaggggt taaaaaataa ttatcccaaa     3140

ctttttaatg tattgctttt tttttttttt tttttccttc tactatacca ttttaagttc     3200

tgacctcagg cctccatttg ggccgatggc ctcttggagg cttaaagttt tctgtacctt     3260

gtgatgaatg ttaataggtg tttttattat acaaagctga atgtcatttc tcgtttgtag     3320

ctttctgtca ctcattccat cttccttcag acatcaccac gtttctctaa agtcagaaaa     3380

cattccgttt tggtcttttt caaaaaggtc ccaaatgctg cactctacac atgaaggccc     3440

tctcacacag acgtgacgtc ctgccagaaa gagaatgaat gacagaaaaa aaaaagagag     3500

acaaactcta ggaacaatgc cgattcattc cacgcagcag tattgggggt ggttcggggg     3560

aggggtgttt cggattttct ttttttcttt tcttttcttt tttttttttt gcagcaacca     3620

ttaataaatg ccaccacatt ctaccagcac aaggaaacat aggcagcact gaaaaaaaaa     3680

aaaaagctca tattaattag actgacaata tggccttgga aggctctccc ttgtggaacc     3740

aagttgccat gggccttggg tgctctgcga taacgggtgt gggttggttt tgtttgcaaa     3800

atggccaaaa aaaaaaaccg gcttccccga gcagctgccc tgaaagtagg ggtggcggcg     3860

gcggcgctga gtttatacat tagttcagac ctacttggtg gcattaaact gtttgaatgc     3920

aaattcgatt tcagattgaa cttgttaagg gagttaacga gggctgagtt cagcaaatgc     3980

taaagtgtta atttcaaata tgcaaatttg gtactgcagt ttgttatgca atattatatc     4040

accaacccag tatcacaaaa actcatagaa gatatcatgt aggccctggg ctttgggggg     4100

gtcccaaaca tggtatgcag aaatgtgatg gttacaggtc agtacaacct cagtccttag     4160

aacccctcca cacttcagct ctgcacccac tttcctgtca tttatttata taggactgta     4220

gtttttttta gttcgagagc ctttcgaagc ttaatttata ttctttcttt gtaccttttt     4280

tctaaaatta ccaaagatat tacacaaagg taaattatgt tctctgtttt atgctttatc     4340

tgatgaagcc aaatatcctc ttattgttga tcaaaggagg caaaagaatt tagaggcaaa     4400

tgacaagcga taggctattg caacctgaga aagagaactg ctccttcatc gtaaatttag     4460

aagaccaagt agataatgga accaaagttg ttactttttt ctagtagtta tttttccttt     4520

ttctttttgt gtacctctac agagaccaaa actcattctc ttaaagagat tttatggggc     4580

tactgcagat aaaaatagga cacaatatta aaggagctac agaaggaagg gagtcccatc     4640

tcaaaaaaaa aatgaatgta tgccactgca attagagtat ccaataaagg agacagttta     4700

gagtcaggac agaaaagctt ccataattga actagattac ataatagtat ttctagaaaa     4760

agagatattt ttagattgta tgccactttt gtttaagaac tgtgctgtga tcactgtatt     4820

aattttggtt tatcttggca tatatccttc agtttgtttt tatttttaat ttttcctttt     4880

tttccgatta ggctttggtc agcatttttc atttaaagaa aagtaacact cccatccact     4940

cataagcttg gtacaaaaac ttctctggca gttacttttg aagcttcact ctgctttctg     5000

tataaagggc agtctgtggt cacgcaagac tttaaaaaaa aaaaaaaaaa aaaaaaaaaa     5060

aaaaaaaaaa aaaacttttc caggcagctt catgatgtgc aggcagtagc cagacagggt     5120

catgggaagg gggccctgtg cttctaaact gagtggttgc tggttagttt ggtattcaaa     5180

agaggataaa aatctggtag attagttcat tctcagcatg tgtagctaga catgagtaaa     5240

gataacagca tgagaaactg ttagtacgca tacctcagtt caaaccttta gggaatgatt     5300

aaaatttaaa aaaaaaacat ttcactcagt tgcacttagt cgtatgtctt gcatgcttag     5360

tctaaagact gtagcaaaaa aaaaaaaaaa agaaaaatta gattttacat atctttgcag     5420

gtatcacagc cttgcagaag aaccaactga aaaaaaaatt ctcaggcttt acagcaagca     5480

aacttcacta tgatttttac aattctgatt ctgtatcccc tgggggttat cccagttgct     5540

tctttaggat ggggtttatt acgttgtaca tatatcccga tgtgtctgtg tgaatctttg     5600

tcttttttgg gggagggcag agggcggttc tttttttaga tattgttcct aaaaaggaat     5660

aaatgcatac acctgtttgt caaaacacct ttgctttttg tgcaactgct ttatattaac     5720

gatactaaaa aaaaatagct ttggaaaaaa aactactgta tgtaacggaa ttgcagaata     5780

tgctgcacat gtattttatt tagttatcct tgctttaaga atattggatg acatttcctg     5840

acatgtggga gggagaaact ccctaacttt ttttttctgc ttttaaactg taacatagtt     5900

gaagatttct tttttctgtt ctcattgatt ggagcatttt gtacaggttt tgtgtgtgtg     5960

tgtgtgtgtg tgtgcgcgcg tgcgtgtgtg ttaatctgtt ttttgataca ttcctatccc     6020

ttgtgtttat cctaccactg ccttcctggc tatcttaaac aagttcatac atttgaaaag     6080

aaaaaaaaat gttgtttaaa aaatgttttc tcctgctgca gtaaatattt tgcatgatga     6140

aattccaggg tcacactttt ccaagtttat cagtgaagta gtgattaaca atggggagtg     6200

tcaaaactat tgaacttttg tataaaaaaa aaaaaacttt acaaggtgcc aagatgtaaa     6260

gaaaatctgt tacttttttt ttctcaaaga aaagcataca ttagggaggt agtcccgtgt     6320

gtcagacaaa tgcactgtca ggaatgagga tccaacctac ctgtccctag agtccgtctt     6380

gtaagatgag ttaggctgcc ccttggacca gccacaaaat ggaatatcaa ggcttatgta     6440

catacgtgaa gagttaccac cagtcctgcc acctttggac agctctaaca ccatccccag     6500

catccagtca gacctagtaa agaaaacctt ggattcttaa cccaagatag gctgtaaatc     6560

actagctttt ttttcctcat gaaaaaaaat agagttaaaa aatatttcct ctcttttcca     6620

tattccagct gaactccgtt tccaaaggca caaagaagag tgtgcttatt cagattttga     6680

atctttttgg taccttttgg ttaatgacat agcctcctga aattctggat gtcttcaaag     6740

tcagttttgc ttctttatcc tgaaaatcag atttacaatg ctgaaggcat ttcttgggcc     6800

cagtgtagct cacgcaatct ctgctaccca taagccttga tgaagatgat acagtccgga     6860

ctgtgagcat ggtgcttcat gtatatgtgc tgccagtaac aagaattttt ttgttttgtt     6920

ttgttttgtt ttgataaggc ataaaagaaa ctcattcctt gacatcaact gtaattccat     6980

cattccatgt ctgcggatac agacaataaa aaaaatgttg tgtagtcagt actaattact     7040

gacattataa gcattctcaa atgcaataaa aatgctggtt gttcacgctg gtaaaaaaaa     7100

aa                                                                    7102


<210>  2
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Ala Leu Gln Val 
    50                  55                  60                  


Ala Arg Gln Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln Val Ser Gly 
65                  70                  75                  80  


Leu Lys Ser Pro Lys Arg Asn Asp Lys Gln Pro Ala Leu Gln Val Pro 
                85                  90                  95      


Val Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met 
            100                 105                 110         


Gln Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val 
        115                 120                 125             


Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln 
    130                 135                 140                 


Glu Phe Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln 
145                 150                 155                 160 


Gln Gln His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr 
                165                 170                 175     


Gln Gln Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln 
            180                 185                 190         


Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln 
        195                 200                 205             


Pro Gly Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile 
    210                 215                 220                 


Pro Thr Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr 
225                 230                 235                 240 


Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr 
                245                 250                 255     


Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn 
            260                 265                 270         


Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg 
        275                 280                 285             


Glu Ser Leu Ser His Glu Glu His Pro His Ser His Pro Leu Tyr Gly 
    290                 295                 300                 


His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe 
305                 310                 315                 320 


Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg 
                325                 330                 335     


Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu 
            340                 345                 350         


Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His 
        355                 360                 365             


Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn 
    370                 375                 380                 


Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro 
385                 390                 395                 400 


Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro 
                405                 410                 415     


Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val 
            420                 425                 430         


Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser 
        435                 440                 445             


Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg 
    530                 535                 540                 


Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln 
545                 550                 555                 560 


Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser 
                565                 570                 575     


Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn 
            580                 585                 590         


Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly 
        595                 600                 605             


Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg 
    610                 615                 620                 


Ser Pro Met Gln Ala Val His Pro Val His Val Lys Glu Glu Pro Leu 
625                 630                 635                 640 


Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn 
                645                 650                 655     


His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val 
            660                 665                 670         


Asn Glu Asp Met Glu 
        675         


<210>  3
<211>  6394
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (119)..(1852)

<400>  3
cagtccgcct gcacgccgag gccgccggac cccacgcccg gcccgcgcgg gcgccccgag       60

cccggctccg cgcgcctggc ggctacatgg agagtgtcag gttcccgtgt cagtggct        118

atg atg aca cct caa gtt atc act ccc cag caa atg cag cag atc ctc        166
Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu           
1               5                   10                  15                

cag caa caa gtg ctg agc cct cag cag ctc cag gtt ctc ctc cag cag        214
Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln           
            20                  25                  30                    

cag cag gcc ctc atg ctt caa cag cag cag ctt caa gag ttt tat aaa        262
Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys           
        35                  40                  45                        

aaa caa cag gaa cag ttg cag ctt caa ctt tta caa caa caa cat gct        310
Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala           
    50                  55                  60                            

gga aaa cag cct aaa gag caa cag cag gtg gct acc cag cag ttg gct        358
Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala           
65                  70                  75                  80            

ttt cag cag cag ctt tta cag atg cag cag tta cag cag cag cac ctc        406
Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu           
                85                  90                  95                

ctg tct ttg cag cgc caa ggc ctt ctg aca att cag ccc ggg cag cct        454
Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro           
            100                 105                 110                   

gcc ctt ccc ctt caa cct ctt gct caa ggc atg att cca aca gaa ctg        502
Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu           
        115                 120                 125                       

cag cag ctc tgg aaa gaa gtg aca agt gct cat act gca gaa gaa acc        550
Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr           
    130                 135                 140                           

aca ggc aac aat cac agc agt ttg gat ctg acc acg aca tgt gtc tcc        598
Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser           
145                 150                 155                 160           

tcc tct gca cct tcc aag acc tcc tta ata atg aac cca cat gcc tct        646
Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser           
                165                 170                 175               

acc aat gga cag ctc tca gtc cac act ccc aaa agg gaa agt ttg tcc        694
Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser           
            180                 185                 190                   

cat gag gag cac ccc cat agc cat cct ctc tat gga cat ggt gta tgc        742
His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys           
        195                 200                 205                       

aag tgg cca ggc tgt gaa gca gtg tgc gaa gat ttc caa tca ttt cta        790
Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu           
    210                 215                 220                           

aaa cat ctc aac agt gag cat gcg ctg gac gat aga agt aca gcc caa        838
Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln           
225                 230                 235                 240           

tgt aga gta caa atg cag gtt gta cag cag tta gag cta cag ctt gca        886
Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala           
                245                 250                 255               

aaa gac aaa gaa cgc ctg caa gcc atg atg acc cac ctg cat gtg aag        934
Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys           
            260                 265                 270                   

tct aca gaa ccc aaa gcc gcc cct cag ccc ttg aat ctg gta tca agt        982
Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser           
        275                 280                 285                       

gtc act ctc tcc aag tcc gca tcg gag gct tct cca cag agc tta cct       1030
Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro           
    290                 295                 300                           

cat act cca acg acc cca acc gcc ccc ctg act ccc gtc acc caa ggc       1078
His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly           
305                 310                 315                 320           

ccc tct gtc atc aca acc acc agc atg cac acg gtg gga ccc atc cgc       1126
Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg           
                325                 330                 335               

agg cgg tac tca gac aaa tac aac gtg ccc att tcg tca gca gat att       1174
Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile           
            340                 345                 350                   

gcg cag aac caa gaa ttt tat aag aac gca gaa gtt aga cca cca ttt       1222
Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe           
        355                 360                 365                       

aca tat gca tct tta att agg cag gcc att ctc gaa tct cca gaa aag       1270
Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys           
    370                 375                 380                           

cag cta aca cta aat gag atc tat aac tgg ttc aca cga atg ttt gct       1318
Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala           
385                 390                 395                 400           

tac ttc cga cgc aac gcg gcc acg tgg aag aat gca gtg cgt cat aat       1366
Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn           
                405                 410                 415               

ctt agt ctt cac aag tgt ttt gtg cga gta gaa aac gtt aaa ggg gca       1414
Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala           
            420                 425                 430                   

gta tgg aca gtg gat gaa gta gaa ttc caa aaa cga agg cca caa aag       1462
Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys           
        435                 440                 445                       

atc agt ggt aac cct tcc ctt att aaa aac atg cag agc agc cac gcc       1510
Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala           
    450                 455                 460                           

tac tgc aca cct ctc aat gca gct tta cag gct tca atg gct gag aat       1558
Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn           
465                 470                 475                 480           

agt ata cct cta tac act acc gct tcc atg gga aat ccc act ctg ggc       1606
Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly           
                485                 490                 495               

aac tta gcc agc gca ata cgg gaa gag ctg aac ggg gca atg gag cat       1654
Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His           
            500                 505                 510                   

acc aac agc aac gag agt gac agc agt cca ggc aga tct cct atg caa       1702
Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln           
        515                 520                 525                       

gcc gtg cat cct gta cac gtc aaa gaa gag ccc ctc gat cca gag gaa       1750
Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu           
    530                 535                 540                           

gct gaa ggg ccc ctg tcc tta gtg aca aca gcc aac cac agt cca gat       1798
Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp           
545                 550                 555                 560           

ttt gac cat gac aga gat tac gaa gat gaa cca gta aac gag gac atg       1846
Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met           
                565                 570                 575               

gag tga ctatcggggc gggccaaccc cgagaatgaa gattggaaaa aggaaaaaaa        1902
Glu                                                                       
                                                                          

aaaaaacacg tcaaaagtta gcagtgaaat tgttctccat ttgttgtaca gtctggagga     1962

ttttcactac gttttgacaa ctctgaaatg tgttaactct tagtgccatc aagaacccca     2022

tttgggagta tttttgattt ttctactttt tgttgaaaaa aggaatttgt actctgtgca     2082

ttggatggac ttgtttggta cttgggattt tcctctctta accgtcaaca tcagtgttgt     2142

aaatttgcta aactgattca cttttagcag cagactttga actgcagtcc tgccaacgtt     2202

ggacactgag gacgcccgac agagcttgtg cacctaagct gcagaccaag cctttgccca     2262

gaatttaagg attccaatgg acgacctatt tgcacagtac tgcatgttga ttatcactgc     2322

ctttactcct tttttttttt tttttttttt tttttttttg cttccagttg ggatggggaa     2382

ggcctttgtg tgtgtattgg ggggaggggt taaaaaataa ttatcccaaa ctttttaatg     2442

tattgctttt tttttttttt tttttccttc tactatacca ttttaagttc tgacctcagg     2502

cctccatttg ggccgatggc ctcttggagg cttaaagttt tctgtacctt gtgatgaatg     2562

ttaataggtg tttttattat acaaagctga atgtcatttc tcgtttgtag ctttctgtca     2622

ctcattccat cttccttcag acatcaccac gtttctctaa agtcagaaaa cattccgttt     2682

tggtcttttt caaaaaggtc ccaaatgctg cactctacac atgaaggccc tctcacacag     2742

acgtgacgtc ctgccagaaa gagaatgaat gacagaaaaa aaaaagagag acaaactcta     2802

ggaacaatgc cgattcattc cacgcagcag tattgggggt ggttcggggg aggggtgttt     2862

cggattttct ttttttcttt tcttttcttt tttttttttt gcagcaacca ttaataaatg     2922

ccaccacatt ctaccagcac aaggaaacat aggcagcact gaaaaaaaaa aaaaagctca     2982

tattaattag actgacaata tggccttgga aggctctccc ttgtggaacc aagttgccat     3042

gggccttggg tgctctgcga taacgggtgt gggttggttt tgtttgcaaa atggccaaaa     3102

aaaaaaaccg gcttccccga gcagctgccc tgaaagtagg ggtggcggcg gcggcgctga     3162

gtttatacat tagttcagac ctacttggtg gcattaaact gtttgaatgc aaattcgatt     3222

tcagattgaa cttgttaagg gagttaacga gggctgagtt cagcaaatgc taaagtgtta     3282

atttcaaata tgcaaatttg gtactgcagt ttgttatgca atattatatc accaacccag     3342

tatcacaaaa actcatagaa gatatcatgt aggccctggg ctttgggggg gtcccaaaca     3402

tggtatgcag aaatgtgatg gttacaggtc agtacaacct cagtccttag aacccctcca     3462

cacttcagct ctgcacccac tttcctgtca tttatttata taggactgta gtttttttta     3522

gttcgagagc ctttcgaagc ttaatttata ttctttcttt gtaccttttt tctaaaatta     3582

ccaaagatat tacacaaagg taaattatgt tctctgtttt atgctttatc tgatgaagcc     3642

aaatatcctc ttattgttga tcaaaggagg caaaagaatt tagaggcaaa tgacaagcga     3702

taggctattg caacctgaga aagagaactg ctccttcatc gtaaatttag aagaccaagt     3762

agataatgga accaaagttg ttactttttt ctagtagtta tttttccttt ttctttttgt     3822

gtacctctac agagaccaaa actcattctc ttaaagagat tttatggggc tactgcagat     3882

aaaaatagga cacaatatta aaggagctac agaaggaagg gagtcccatc tcaaaaaaaa     3942

aatgaatgta tgccactgca attagagtat ccaataaagg agacagttta gagtcaggac     4002

agaaaagctt ccataattga actagattac ataatagtat ttctagaaaa agagatattt     4062

ttagattgta tgccactttt gtttaagaac tgtgctgtga tcactgtatt aattttggtt     4122

tatcttggca tatatccttc agtttgtttt tatttttaat ttttcctttt tttccgatta     4182

ggctttggtc agcatttttc atttaaagaa aagtaacact cccatccact cataagcttg     4242

gtacaaaaac ttctctggca gttacttttg aagcttcact ctgctttctg tataaagggc     4302

agtctgtggt cacgcaagac tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4362

aaaacttttc caggcagctt catgatgtgc aggcagtagc cagacagggt catgggaagg     4422

gggccctgtg cttctaaact gagtggttgc tggttagttt ggtattcaaa agaggataaa     4482

aatctggtag attagttcat tctcagcatg tgtagctaga catgagtaaa gataacagca     4542

tgagaaactg ttagtacgca tacctcagtt caaaccttta gggaatgatt aaaatttaaa     4602

aaaaaaacat ttcactcagt tgcacttagt cgtatgtctt gcatgcttag tctaaagact     4662

gtagcaaaaa aaaaaaaaaa agaaaaatta gattttacat atctttgcag gtatcacagc     4722

cttgcagaag aaccaactga aaaaaaaatt ctcaggcttt acagcaagca aacttcacta     4782

tgatttttac aattctgatt ctgtatcccc tgggggttat cccagttgct tctttaggat     4842

ggggtttatt acgttgtaca tatatcccga tgtgtctgtg tgaatctttg tcttttttgg     4902

gggagggcag agggcggttc tttttttaga tattgttcct aaaaaggaat aaatgcatac     4962

acctgtttgt caaaacacct ttgctttttg tgcaactgct ttatattaac gatactaaaa     5022

aaaaatagct ttggaaaaaa aactactgta tgtaacggaa ttgcagaata tgctgcacat     5082

gtattttatt tagttatcct tgctttaaga atattggatg acatttcctg acatgtggga     5142

gggagaaact ccctaacttt ttttttctgc ttttaaactg taacatagtt gaagatttct     5202

tttttctgtt ctcattgatt ggagcatttt gtacaggttt tgtgtgtgtg tgtgtgtgtg     5262

tgtgcgcgcg tgcgtgtgtg ttaatctgtt ttttgataca ttcctatccc ttgtgtttat     5322

cctaccactg ccttcctggc tatcttaaac aagttcatac atttgaaaag aaaaaaaaat     5382

gttgtttaaa aaatgttttc tcctgctgca gtaaatattt tgcatgatga aattccaggg     5442

tcacactttt ccaagtttat cagtgaagta gtgattaaca atggggagtg tcaaaactat     5502

tgaacttttg tataaaaaaa aaaaaacttt acaaggtgcc aagatgtaaa gaaaatctgt     5562

tacttttttt ttctcaaaga aaagcataca ttagggaggt agtcccgtgt gtcagacaaa     5622

tgcactgtca ggaatgagga tccaacctac ctgtccctag agtccgtctt gtaagatgag     5682

ttaggctgcc ccttggacca gccacaaaat ggaatatcaa ggcttatgta catacgtgaa     5742

gagttaccac cagtcctgcc acctttggac agctctaaca ccatccccag catccagtca     5802

gacctagtaa agaaaacctt ggattcttaa cccaagatag gctgtaaatc actagctttt     5862

ttttcctcat gaaaaaaaat agagttaaaa aatatttcct ctcttttcca tattccagct     5922

gaactccgtt tccaaaggca caaagaagag tgtgcttatt cagattttga atctttttgg     5982

taccttttgg ttaatgacat agcctcctga aattctggat gtcttcaaag tcagttttgc     6042

ttctttatcc tgaaaatcag atttacaatg ctgaaggcat ttcttgggcc cagtgtagct     6102

cacgcaatct ctgctaccca taagccttga tgaagatgat acagtccgga ctgtgagcat     6162

ggtgcttcat gtatatgtgc tgccagtaac aagaattttt ttgttttgtt ttgttttgtt     6222

ttgataaggc ataaaagaaa ctcattcctt gacatcaact gtaattccat cattccatgt     6282

ctgcggatac agacaataaa aaaaatgttg tgtagtcagt actaattact gacattataa     6342

gcattctcaa atgcaataaa aatgctggtt gttcacgctg gtaaaaaaaa aa             6394


<210>  4
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys 
        35                  40                  45              


Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln His Ala 
    50                  55                  60                  


Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln Leu Ala 
65                  70                  75                  80  


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
                85                  90                  95      


Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly Gln Pro 
            100                 105                 110         


Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr Glu Leu 
        115                 120                 125             


Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu Glu Thr 
    130                 135                 140                 


Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys Val Ser 
145                 150                 155                 160 


Ser Ser Ala Pro Ser Lys Thr Ser Leu Ile Met Asn Pro His Ala Ser 
                165                 170                 175     


Thr Asn Gly Gln Leu Ser Val His Thr Pro Lys Arg Glu Ser Leu Ser 
            180                 185                 190         


His Glu Glu His Pro His Ser His Pro Leu Tyr Gly His Gly Val Cys 
        195                 200                 205             


Lys Trp Pro Gly Cys Glu Ala Val Cys Glu Asp Phe Gln Ser Phe Leu 
    210                 215                 220                 


Lys His Leu Asn Ser Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln 
225                 230                 235                 240 


Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Leu Gln Leu Ala 
                245                 250                 255     


Lys Asp Lys Glu Arg Leu Gln Ala Met Met Thr His Leu His Val Lys 
            260                 265                 270         


Ser Thr Glu Pro Lys Ala Ala Pro Gln Pro Leu Asn Leu Val Ser Ser 
        275                 280                 285             


Val Thr Leu Ser Lys Ser Ala Ser Glu Ala Ser Pro Gln Ser Leu Pro 
    290                 295                 300                 


His Thr Pro Thr Thr Pro Thr Ala Pro Leu Thr Pro Val Thr Gln Gly 
305                 310                 315                 320 


Pro Ser Val Ile Thr Thr Thr Ser Met His Thr Val Gly Pro Ile Arg 
                325                 330                 335     


Arg Arg Tyr Ser Asp Lys Tyr Asn Val Pro Ile Ser Ser Ala Asp Ile 
            340                 345                 350         


Ala Gln Asn Gln Glu Phe Tyr Lys Asn Ala Glu Val Arg Pro Pro Phe 
        355                 360                 365             


Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu Ser Pro Glu Lys 
    370                 375                 380                 


Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr Arg Met Phe Ala 
385                 390                 395                 400 


Tyr Phe Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn 
                405                 410                 415     


Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala 
            420                 425                 430         


Val Trp Thr Val Asp Glu Val Glu Phe Gln Lys Arg Arg Pro Gln Lys 
        435                 440                 445             


Ile Ser Gly Asn Pro Ser Leu Ile Lys Asn Met Gln Ser Ser His Ala 
    450                 455                 460                 


Tyr Cys Thr Pro Leu Asn Ala Ala Leu Gln Ala Ser Met Ala Glu Asn 
465                 470                 475                 480 


Ser Ile Pro Leu Tyr Thr Thr Ala Ser Met Gly Asn Pro Thr Leu Gly 
                485                 490                 495     


Asn Leu Ala Ser Ala Ile Arg Glu Glu Leu Asn Gly Ala Met Glu His 
            500                 505                 510         


Thr Asn Ser Asn Glu Ser Asp Ser Ser Pro Gly Arg Ser Pro Met Gln 
        515                 520                 525             


Ala Val His Pro Val His Val Lys Glu Glu Pro Leu Asp Pro Glu Glu 
    530                 535                 540                 


Ala Glu Gly Pro Leu Ser Leu Val Thr Thr Ala Asn His Ser Pro Asp 
545                 550                 555                 560 


Phe Asp His Asp Arg Asp Tyr Glu Asp Glu Pro Val Asn Glu Asp Met 
                565                 570                 575     


Glu 
    


<210>  5
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  5
aaucugggac ugagacaaa                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  6
gaugcaagaa ucugggacu                                                    19


