                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  DePinho DFCI 1615 Photoactivation of CreER/Iox P

<130>  00530-0298WO1

<150>  US 61/635,068
<151>  2012-04-18

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  2
<211>  6330
<212>  DNA
<213>  Homo sapiens

<400>  2
aggagctggc ggagggcgtt cgtcctggga ctgcacttgc tcccgtcggg tcgcccggct       60

tcaccggacc cgcaggctcc cggggcaggg ccggggccag agctcgcgtg tcggcgggac      120

atgcgctgcg tcgcctctaa cctcgggctg tgctcttttt ccaggtggcc cgccggtttc      180

tgagccttct gccctgcggg gacacggtct gcaccctgcc cgcggccacg gaccatgacc      240

atgaccctcc acaccaaagc atctgggatg gccctactgc atcagatcca agggaacgag      300

ctggagcccc tgaaccgtcc gcagctcaag atccccctgg agcggcccct gggcgaggtg      360

tacctggaca gcagcaagcc cgccgtgtac aactaccccg agggcgccgc ctacgagttc      420

aacgccgcgg ccgccgccaa cgcgcaggtc tacggtcaga ccggcctccc ctacggcccc      480

gggtctgagg ctgcggcgtt cggctccaac ggcctggggg gtttcccccc actcaacagc      540

gtgtctccga gcccgctgat gctactgcac ccgccgccgc agctgtcgcc tttcctgcag      600

ccccacggcc agcaggtgcc ctactacctg gagaacgagc ccagcggcta cacggtgcgc      660

gaggccggcc cgccggcatt ctacaggcca aattcagata atcgacgcca gggtggcaga      720

gaaagattgg ccagtaccaa tgacaaggga agtatggcta tggaatctgc caaggagact      780

cgctactgtg cagtgtgcaa tgactatgct tcaggctacc attatggagt ctggtcctgt      840

gagggctgca aggccttctt caagagaagt attcaaggac ataacgacta tatgtgtcca      900

gccaccaacc agtgcaccat tgataaaaac aggaggaaga gctgccaggc ctgccggctc      960

cgcaaatgct acgaagtggg aatgatgaaa ggtgggatac gaaaagaccg aagaggaggg     1020

agaatgttga aacacaagcg ccagagagat gatggggagg gcaggggtga agtggggtct     1080

gctggagaca tgagagctgc caacctttgg ccaagcccgc tcatgatcaa acgctctaag     1140

aagaacagcc tggccttgtc cctgacggcc gaccagatgg tcagtgcctt gttggatgct     1200

gagcccccca tactctattc cgagtatgat cctaccagac ccttcagtga agcttcgatg     1260

atgggcttac tgaccaacct ggcagacagg gagctggttc acatgatcaa ctgggcgaag     1320

agggtgccag gctttgtgga tttgaccctc catgatcagg tccaccttct agaatgtgcc     1380

tggctagaga tcctgatgat tggtctcgtc tggcgctcca tggagcaccc agggaagcta     1440

ctgtttgctc ctaacttgct cttggacagg aaccagggaa aatgtgtaga gggcatggtg     1500

gagatcttcg acatgctgct ggctacatca tctcggttcc gcatgatgaa tctgcaggga     1560

gaggagtttg tgtgcctcaa atctattatt ttgcttaatt ctggagtgta cacatttctg     1620

tccagcaccc tgaagtctct ggaagagaag gaccatatcc accgagtcct ggacaagatc     1680

acagacactt tgatccacct gatggccaag gcaggcctga ccctgcagca gcagcaccag     1740

cggctggccc agctcctcct catcctctcc cacatcaggc acatgagtaa caaaggcatg     1800

gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc tctatgacct gctgctggag     1860

atgctggacg cccaccgcct acatgcgccc actagccgtg gaggggcatc cgtggaggag     1920

acggaccaaa gccacttggc cactgcgggc tctacttcat cgcattcctt gcaaaagtat     1980

tacatcacgg gggaggcaga gggtttccct gccacggtct gagagctccc tggctcccac     2040

acggttcaga taatccctgc tgcattttac cctcatcatg caccacttta gccaaattct     2100

gtctcctgca tacactccgg catgcatcca acaccaatgg ctttctagat gagtggccat     2160

tcatttgctt gctcagttct tagtggcaca tcttctgtct tctgttggga acagccaaag     2220

ggattccaag gctaaatctt tgtaacagct ctctttcccc cttgctatgt tactaagcgt     2280

gaggattccc gtagctcttc acagctgaac tcagtctatg ggttggggct cagataactc     2340

tgtgcattta agctacttgt agagacccag gcctggagag tagacatttt gcctctgata     2400

agcacttttt aaatggctct aagaataagc cacagcaaag aatttaaagt ggctccttta     2460

attggtgact tggagaaagc taggtcaagg gtttattata gcaccctctt gtattcctat     2520

ggcaatgcat ccttttatga aagtggtaca ccttaaagct tttatatgac tgtagcagag     2580

tatctggtga ttgtcaattc attcccccta taggaataca aggggcacac agggaaggca     2640

gatcccctag ttggcaagac tattttaact tgatacactg cagattcaga tgtgctgaaa     2700

gctctgcctc tggctttccg gtcatgggtt ccagttaatt catgcctccc atggacctat     2760

ggagagcagc aagttgatct tagttaagtc tccctatatg agggataagt tcctgatttt     2820

tgtttttatt tttgtgttac aaaagaaagc cctccctccc tgaacttgca gtaaggtcag     2880

cttcaggacc tgttccagtg ggcactgtac ttggatcttc ccggcgtgtg tgtgccttac     2940

acaggggtga actgttcact gtggtgatgc atgatgaggg taaatggtag ttgaaaggag     3000

caggggccct ggtgttgcat ttagccctgg ggcatggagc tgaacagtac ttgtgcagga     3060

ttgttgtggc tactagagaa caagagggaa agtagggcag aaactggata cagttctgag     3120

gcacagccag acttgctcag ggtggccctg ccacaggctg cagctaccta ggaacattcc     3180

ttgcagaccc cgcattgccc tttgggggtg ccctgggatc cctggggtag tccagctctt     3240

cttcatttcc cagcgtggcc ctggttggaa gaagcagctg tcacagctgc tgtagacagc     3300

tgtgttccta caattggccc agcaccctgg ggcacgggag aagggtgggg accgttgctg     3360

tcactactca ggctgactgg ggcctggtca gattacgtat gcccttggtg gtttagagat     3420

aatccaaaat cagggtttgg tttggggaag aaaatcctcc cccttcctcc cccgccccgt     3480

tccctaccgc ctccactcct gccagctcat ttccttcaat ttcctttgac ctataggcta     3540

aaaaagaaag gctcattcca gccacagggc agccttccct gggcctttgc ttctctagca     3600

caattatggg ttacttcctt tttcttaaca aaaaagaatg tttgatttcc tctgggtgac     3660

cttattgtct gtaattgaaa ccctattgag aggtgatgtc tgtgttagcc aatgacccag     3720

gtgagctgct cgggcttctc ttggtatgtc ttgtttggaa aagtggattt cattcatttc     3780

tgattgtcca gttaagtgat caccaaagga ctgagaatct gggagggcaa aaaaaaaaaa     3840

aaagttttta tgtgcactta aatttgggga caattttatg tatctgtgtt aaggatatgt     3900

ttaagaacat aattcttttg ttgctgtttg tttaagaagc accttagttt gtttaagaag     3960

caccttatat agtataatat atattttttt gaaattacat tgcttgttta tcagacaatt     4020

gaatgtagta attctgttct ggatttaatt tgactgggtt aacatgcaaa aaccaaggaa     4080

aaatatttag tttttttttt tttttttgta tacttttcaa gctaccttgt catgtataca     4140

gtcatttatg cctaaagcct ggtgattatt catttaaatg aagatcacat ttcatatcaa     4200

cttttgtatc cacagtagac aaaatagcac taatccagat gcctattgtt ggatactgaa     4260

tgacagacaa tcttatgtag caaagattat gcctgaaaag gaaaattatt cagggcagct     4320

aattttgctt ttaccaaaat atcagtagta atatttttgg acagtagcta atgggtcagt     4380

gggttctttt taatgtttat acttagattt tcttttaaaa aaattaaaat aaaacaaaaa     4440

aaaatttcta ggactagacg atgtaatacc agctaaagcc aaacaattat acagtggaag     4500

gttttacatt attcatccaa tgtgtttcta ttcatgttaa gatactacta catttgaagt     4560

gggcagagaa catcagatga ttgaaatgtt cgcccagggg tctccagcaa ctttggaaat     4620

ctctttgtat ttttacttga agtgccacta atggacagca gatattttct ggctgatgtt     4680

ggtattgggt gtaggaacat gatttaaaaa aaaactcttg cctctgcttt cccccactct     4740

gaggcaagtt aaaatgtaaa agatgtgatt tatctggggg gctcaggtat ggtggggaag     4800

tggattcagg aatctgggga atggcaaata tattaagaag agtattgaaa gtatttggag     4860

gaaaatggtt aattctgggt gtgcaccagg gttcagtaga gtccacttct gccctggaga     4920

ccacaaatca actagctcca tttacagcca tttctaaaat ggcagcttca gttctagaga     4980

agaaagaaca acatcagcag taaagtccat ggaatagcta gtggtctgtg tttcttttcg     5040

ccattgccta gcttgccgta atgattctat aatgccatca tgcagcaatt atgagaggct     5100

aggtcatcca aagagaagac cctatcaatg taggttgcaa aatctaaccc ctaaggaagt     5160

gcagtctttg atttgatttc cctagtaacc ttgcagatat gtttaaccaa gccatagccc     5220

atgccttttg agggctgaac aaataaggga cttactgata atttactttt gatcacatta     5280

aggtgttctc accttgaaat cttatacact gaaatggcca ttgatttagg ccactggctt     5340

agagtactcc ttcccctgca tgacactgat tacaaatact ttcctattca tactttccaa     5400

ttatgagatg gactgtgggt actgggagtg atcactaaca ccatagtaat gtctaatatt     5460

cacaggcaga tctgcttggg gaagctagtt atgtgaaagg caaatagagt catacagtag     5520

ctcaaaaggc aaccataatt ctctttggtg caggtcttgg gagcgtgatc tagattacac     5580

tgcaccattc ccaagttaat cccctgaaaa cttactctca actggagcaa atgaactttg     5640

gtcccaaata tccatctttt cagtagcgtt aattatgctc tgtttccaac tgcatttcct     5700

ttccaattga attaaagtgt ggcctcgttt ttagtcattt aaaattgttt tctaagtaat     5760

tgctgcctct attatggcac ttcaattttg cactgtcttt tgagattcaa gaaaaatttc     5820

tattcttttt tttgcatcca attgtgcctg aacttttaaa atatgtaaat gctgccatgt     5880

tccaaaccca tcgtcagtgt gtgtgtttag agctgtgcac cctagaaaca acatattgtc     5940

ccatgagcag gtgcctgaga cacagacccc tttgcattca cagagaggtc attggttata     6000

gagacttgaa ttaataagtg acattatgcc agtttctgtt ctctcacagg tgataaacaa     6060

tgctttttgt gcactacata ctcttcagtg tagagctctt gttttatggg aaaaggctca     6120

aatgccaaat tgtgtttgat ggattaatat gcccttttgc cgatgcatac tattactgat     6180

gtgactcggt tttgtcgcag ctttgctttg tttaatgaaa cacacttgta aacctctttt     6240

gcactttgaa aaagaatcca gcgggatgct cgagcacctg taaacaattt tctcaaccta     6300

tttgatgttc aaataaagaa ttaaactaaa                                      6330


<210>  3
<211>  599
<212>  PRT
<213>  Mus musculus

<400>  3

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Met Pro Met Glu Arg Ala Leu Gly Glu Val Tyr Val Asp Asn Ser Lys 
        35                  40                  45              


Pro Thr Val Phe Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ser Ala Pro Val Tyr Gly Gln Ser 
65                  70                  75                  80  


Gly Ile Ala Tyr Gly Pro Gly Ser Glu Ala Ala Ala Phe Ser Ala Asn 
                85                  90                  95      


Ser Leu Gly Ala Phe Pro Gln Leu Asn Ser Val Ser Pro Ser Pro Leu 
            100                 105                 110         


Met Leu Leu His Pro Pro Pro Gln Leu Ser Pro Phe Leu His Pro His 
        115                 120                 125             


Gly Gln Gln Val Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Ala Tyr Ala 
    130                 135                 140                 


Val Arg Asp Thr Gly Pro Pro Ala Phe Tyr Arg Ser Asn Ser Asp Asn 
145                 150                 155                 160 


Arg Arg Gln Asn Gly Arg Glu Arg Leu Ser Ser Ser Asn Glu Lys Gly 
                165                 170                 175     


Asn Met Ile Met Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys 
            180                 185                 190         


Asn Asp Tyr Ala Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly 
        195                 200                 205             


Cys Lys Ala Phe Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met 
    210                 215                 220                 


Cys Pro Ala Thr Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser 
225                 230                 235                 240 


Cys Gln Ala Cys Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys 
                245                 250                 255     


Gly Gly Ile Arg Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys 
            260                 265                 270         


Arg Gln Arg Asp Asp Leu Glu Gly Arg Asn Glu Met Gly Ala Ser Gly 
        275                 280                 285             


Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Val Ile Lys His 
    290                 295                 300                 


Thr Lys Lys Asn Ser Pro Ala Leu Ser Leu Thr Ala Asp Gln Met Val 
305                 310                 315                 320 


Ser Ala Leu Leu Asp Ala Glu Pro Pro Met Ile Tyr Ser Glu Tyr Asp 
                325                 330                 335     


Pro Ser Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn 
            340                 345                 350         


Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val 
        355                 360                 365             


Pro Gly Phe Gly Asp Leu Asn Leu His Asp Gln Val His Leu Leu Glu 
    370                 375                 380                 


Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met 
385                 390                 395                 400 


Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg 
                405                 410                 415     


Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu 
            420                 425                 430         


Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu 
        435                 440                 445             


Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr 
    450                 455                 460                 


Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His 
465                 470                 475                 480 


Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys 
                485                 490                 495     


Ala Gly Leu Thr Leu Gln Gln Gln His Arg Arg Leu Ala Gln Leu Leu 
            500                 505                 510         


Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His 
        515                 520                 525             


Leu Tyr Asn Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu 
    530                 535                 540                 


Leu Glu Met Leu Asp Ala His Arg Leu His Ala Pro Ala Ser Arg Met 
545                 550                 555                 560 


Gly Val Pro Pro Glu Glu Pro Ser Gln Thr Gln Leu Ala Thr Thr Ser 
                565                 570                 575     


Ser Thr Ser Ala His Ser Leu Gln Thr Tyr Tyr Ile Pro Pro Glu Ala 
            580                 585                 590         


Glu Gly Phe Pro Asn Thr Ile 
        595                 


<210>  4
<211>  4319
<212>  DNA
<213>  Mus musculus

<400>  4
acaaggctcc ctgctcagca gccttgtgat gccaggagag gccaatgccc cctcctctgc       60

cattgtctag cttaagaagg cagtctctgg gcgacattct tctcaagcag gtggcccacg      120

cgctgctgag ccctctgcgt gcgcggggag ccagtctgta actcgccggc tgccacttac      180

catgaccatg acccttcaca ccaaagcctc gggaatggcc ttgctgcacc agatccaagg      240

gaacgagctg gagcccctca accgcccgca gctcaagatg cccatggaga gggccctggg      300

cgaggtatac gtggacaaca gcaagcccac tgtgttcaac taccccgagg gcgccgccta      360

cgagttcaac gccgccgccg ccgccgccgc cgccgcctcg gcgccggtct acggccagtc      420

gggcatcgcc tacggccccg ggtcggaggc ggccgccttc agtgccaaca gcctgggggc      480

tttcccccag ctcaacagcg tgtcgcctag cccgctgatg ctgctgcacc cgccgccgca      540

gctgtctcct ttcctgcacc cgcacggcca gcaggtgccc tactacctgg agaacgagcc      600

cagcgcctac gccgtgcgcg acaccggccc tcccgccttc tacaggtcta attctgacaa      660

tcgacgccag aatggccgag agagactgtc cagcagtaac gagaaaggaa acatgatcat      720

ggagtctgcc aaggagactc gctactgtgc cgtgtgcaat gactatgcct ctggctacca      780

ttatggggtc tggtcctgcg aaggctgcaa ggctttcttt aagagaagca ttcaaggaca      840

caatgactac atgtgtccag ctacaaacca atgcaccatt gacaagaacc ggaggaagag      900

ttgccaggcc tgtcggctgc gcaagtgtta cgaagtgggc atgatgaaag gcggcatacg      960

gaaagaccgc cgaggaggga gaatgttgaa gcacaagcgt cagagagatg acttggaagg     1020

ccgaaatgaa atgggtgctt caggagacat gagggctgcc aacctttggc caagccctct     1080

tgtgattaag cacactaaga agaatagccc tgccttgtcc ttgacagctg accagatggt     1140

cagtgccttg ttggatgctg aaccgcccat gatctattct gaatatgatc cttctagacc     1200

cttcagtgaa gcctcaatga tgggcttatt gaccaaccta gcagataggg agctggttca     1260

tatgatcaac tgggcaaaga gagtgccagg ctttggggac ttgaatctcc atgatcaggt     1320

ccaccttctc gagtgtgcct ggctggagat tctgatgatt ggtctcgtct ggcgctccat     1380

ggaacacccg gggaagctcc tgtttgctcc taacttgctc ctggacagga atcaaggtaa     1440

atgtgtggaa ggcatggtgg agatctttga catgttgctg gctacgtcaa gtcggttccg     1500

catgatgaac ctgcagggag aagagtttgt gtgcctcaaa tccatcattt tgcttaattc     1560

cggagtgtac acgtttctgt ccagcacctt gaagtctctg gaagagaagg accacatcca     1620

ccgtgtcctg gacaagatca cagacacttt gatccacctg atggccaaag ctggcctgac     1680

tctgcagcag cagcatcgcc gcctagctca gctccttctc attctttccc atatccggca     1740

catgagtaac aaaggcatgg agcatctcta caacatgaaa tgcaagaacg ttgtgcccct     1800

ctatgacctg ctcctggaga tgttggatgc ccaccgcctt catgccccag ccagtcgcat     1860

gggagtgccc ccagaggagc ccagccagac ccagctggcc accaccagct ccacttcagc     1920

acattcctta caaacctact acataccccc ggaagcagag ggcttcccca acacgatctg     1980

agagctccca ggctccccga aaggttctga gaatccctgc aacattttac ccatgtcatg     2040

tatgactagc agaattctgt ctcctgcgta cactgtggca tgcatccacc accagtggct     2100

ttctagtatg agtggccatt tatttgcttg ctcagttctt agtggcatgt cttctgttgg     2160

gaacaggcaa aagggattcc agggctaaat cttggtaaca gctctctttc tccctttgct     2220

acgtcactaa ctatgaggat tcctatagtc ttcagtcttc atgaatgaat tgagataact     2280

gcattgaagc tacttgttga gacccaagcc tagagagtaa acatttcacc tctgataagc     2340

acttcataat ggctccaaga ggaagcctca gcaaagactt caaagtggct cctttaattg     2400

aagtcgttga caaagcgatc tcatggcttc ctaatagcac ccgcttgcat tcctatagca     2460

acatgtgact ttattaaagg gaaatcttga gcccctatag gaatatgtga tgcacacaga     2520

aaaggaagat gcccccagtt gtcaagacca tgtcaactca atacagtcaa ccttttcact     2580

tcttaaagtg tcagctgccg agtattatat acatggtggg ttctagacaa ttcttgcttc     2640

ccatgacttg tgggaaacag aaagtctatt tcagttaata ccctggaatg aattagtctc     2700

cttcatgagg gctgtagggt gtgttgattt taatttgatt tcattttata atagtcttct     2760

gcccctgggg cttgcagtaa aggcagcttg aggacctgtt ctggtaaact ggacattctt     2820

cagcacagga tgctagcctt gtctcttccc tgatgtcaat tgccctaaat tgttaccatg     2880

tagattgatc aagggcagtc acaatgaacc tgcaagctgg tgacaatttt ttggtttgtt     2940

tagttttatt cttgggggca gggaacaagt aatgtatggg caatgactgt gactcggagg     3000

agtctaagaa ggaaagtaag ggagaaatgt ggagaatgac ctggccaggg cagcagcttc     3060

ccagaggtgc acctcacaga tcccaccatg cacagtgagg ctgctctggg atccatgggc     3120

tgacttcact tacatttcag gtatgagcct gattggaaga ggtgacatca gatacctgtg     3180

ttcctgtaga tgctccagga acttggggaa aggcatgggg gcaagatctt ggagcactca     3240

tgactcaagc tgttgagaag ttgctcagac tagactgtgc ttgattattc tgaactcatc     3300

caaaaaccag ctagtgagat cttggggaga aaaatttctt cctcaacaca gttcatgatc     3360

ttaaattttg taaactagaa atgatgaatg accagaattg ggtcatgaga gtcctttgaa     3420

caaggggata aaaaggaaga cttactctat ccacagccac ccaagacctc tggggtcttg     3480

gtctctctag tacaactaag gattacttcc ttttccaaac caaaatgaaa gttcagtttc     3540

catcccggac ttcatgatct ataatttgaa ctccattgag atatgatggg ttagccaaaa     3600

cctaggtgaa tggctaggct tctcttggcc tgtacttttt ggaatggtgg gttccattaa     3660

tttctgctct cccagttaac tgactatcaa agatgtggaa actgggagag ccaatttttc     3720

ttcttatttt ttttaaattt ctcatacttg ttcatcaaat tcaaggacaa ttttatgtat     3780

atgctttaag aacatgttta agaacctaac tcttttgttt gtgtttaaga agcaccttat     3840

atagtataat atatattttt gttgaagttt aattgcttgt ttattggaca attgaatgta     3900

atagttatgt tctgagtttt aatttgattg ggtttaacac tgcaaaagcc aaggggaaaa     3960

tatttagttt gttttttttt tttttttttg tagacgtttc aaactaccgt gtcatgtatg     4020

cagttattaa tgcctaaagc cttgtgattt tcatttaaat gaagatcaca tttcgtatca     4080

acttttgtat ccacagtaga caaaatagaa ggaatccaca tgcctattgc tgggtgttga     4140

atgacagaca atcttatgta gcagagatta tgcctgggaa ggaaaattat tcagggcagc     4200

taattttgct tttaccaaaa tatctgtagt aatatttttg gacagtagct aatgggtcag     4260

tgggttcttt ttaatgttta tactgagatt tttcttttac aaaaataaaa acaaaaatt      4319


<210>  5
<211>  600
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Met Pro Met Glu Arg Ala Leu Gly Glu Val Tyr Val Asp Asn Ser Lys 
        35                  40                  45              


Pro Ala Val Phe Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Gly Ala Ser Ala Pro Val Tyr Gly Gln 
65                  70                  75                  80  


Ser Ser Ile Thr Tyr Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ala 
                85                  90                  95      


Asn Ser Leu Gly Ala Phe Pro Gln Leu Asn Ser Val Ser Pro Ser Pro 
            100                 105                 110         


Leu Met Leu Leu His Pro Pro Pro His Val Ser Pro Phe Leu His Pro 
        115                 120                 125             


His Gly His Gln Val Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Ala Tyr 
    130                 135                 140                 


Ala Val Arg Asp Thr Gly Pro Pro Ala Phe Tyr Arg Ser Asn Ser Asp 
145                 150                 155                 160 


Asn Arg Arg Gln Asn Gly Arg Glu Arg Leu Ser Ser Ser Ser Glu Lys 
                165                 170                 175     


Gly Asn Met Ile Met Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val 
            180                 185                 190         


Cys Asn Asp Tyr Ala Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu 
        195                 200                 205             


Gly Cys Lys Ala Phe Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr 
    210                 215                 220                 


Met Cys Pro Ala Thr Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys 
225                 230                 235                 240 


Ser Cys Gln Ala Cys Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met 
                245                 250                 255     


Lys Gly Gly Ile Arg Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His 
            260                 265                 270         


Lys Arg Gln Arg Asp Asp Leu Glu Gly Arg Asn Glu Met Gly Thr Ser 
        275                 280                 285             


Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Val Ile Lys 
    290                 295                 300                 


His Thr Lys Lys Asn Ser Pro Ala Leu Ser Leu Thr Ala Asp Gln Met 
305                 310                 315                 320 


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Leu Ile Tyr Ser Glu Tyr 
                325                 330                 335     


Asp Pro Ser Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
            340                 345                 350         


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
        355                 360                 365             


Val Pro Gly Phe Gly Asp Leu Asn Leu His Asp Gln Val His Leu Leu 
    370                 375                 380                 


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
385                 390                 395                 400 


Met Glu His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
                405                 410                 415     


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
            420                 425                 430         


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
        435                 440                 445             


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
    450                 455                 460                 


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
465                 470                 475                 480 


His Arg Val Leu Asp Lys Ile Asn Asp Thr Leu Ile His Leu Met Ala 
                485                 490                 495     


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Arg Arg Leu Ala Gln Leu 
            500                 505                 510         


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
        515                 520                 525             


His Leu Tyr Asn Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu 
    530                 535                 540                 


Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Pro Ala Ser Arg 
545                 550                 555                 560 


Met Gly Val Pro Pro Glu Glu Pro Ser Gln Ser Gln Leu Thr Thr Thr 
                565                 570                 575     


Ser Ser Thr Ser Ala His Ser Leu Gln Thr Tyr Tyr Ile Pro Pro Glu 
            580                 585                 590         


Ala Glu Gly Phe Pro Asn Thr Ile 
        595                 600 


<210>  6
<211>  2090
<212>  DNA
<213>  Rattus norvegicus

<400>  6
ccacacacgc tctgccttga tcacacaccg cgccactcga tcattcgagc acattccttc       60

cttccgtctt actgtctcag ctcttgactt ctacaaaccc atggaacatt tctggaaaga      120

cgcttttgaa ccagcagggt ggctcatccg ctgctgagcc ctctgcgtgc gcgggaagcc      180

aatctgtacc tcggcggctg ccactgacca tgaccatgac ccttcacacc aaagcctcgg      240

gaatggcctt gttgcaccag atccaaggga acgagctgga gcccctcaat cgcccgcagc      300

tcaagatgcc catggagagg gctctgggcg aggtgtacgt ggacaacagc aagcccgccg      360

tgttcaacta ccccgagggc gccgcctacg agttcaacgc cgccgccgcc gccgcggccg      420

ccggggcctc ggctccggtc tatggccagt cgagcatcac ttacggtccg gggtccgagg      480

cggccgcctt tggtgccaat agtctggggg ctttccccca gctcaacagc gtgtcgccca      540

gtccgctgat gctgctgcac ccgccgccgc acgtgtcgcc gttcctgcac ccgcatggcc      600

accaggtgcc ctactacctg gagaacgagc ccagcgccta cgctgtacgc gacaccggcc      660

ctcccgcctt ctacaggtcc aattctgaca atcgacgcca gaatggccga gagagactct      720

ccagcagcag cgagaaggga aacatgatca tggagtctgc caaggagact cgctactgtg      780

ctgtgtgtaa cgactatgcc tctggctacc attatggggt ctggtcctgt gaaggctgca      840

aggctttctt taagagaagc attcaaggac ataatgacta catgtgtcca gctacaaacc      900

aatgcaccat cgataagaac cggaggaaga gttgccaggc ctgccggctg cgcaagtgtt      960

acgaagtggg catgatgaaa ggcgggatac gaaaagaccg ccgaggaggg agaatgttga     1020

agcacaagcg tcagagagat gacttggaag gccgaaatga aatgggcact tcaggagaca     1080

tgagagctgc caacctttgg ccaagtccac ttgtgatcaa gcacactaag aagaatagcc     1140

ccgccctgtc cttgacagct gaccagatgg tcagtgcctt attggatgct gaaccacctt     1200

tgatctattc tgaatatgat ccttctagac ccttcagtga agcctcaatg atgggcttat     1260

tgaccaacct ggcagacagg gagctggttc atatgatcaa ctgggcaaag agagtgccag     1320

gctttgggga cttgaatctc cacgatcaag ttcaccttct ggagtgtgcc tggttggaga     1380

tcctgatgat tggtctggtc tggcgctcca tggaacaccc ggggaagctc ctgtttgctc     1440

ctaacttgct cttggacagg aatcaaggta aatgtgtaga aggcatggtg gagatctttg     1500

acatgttgct ggctacgtca agtcgattcc gcatgatgaa cctgcaggga gaagagtttg     1560

tgtgcctcaa atcaatcatt ttgcttaatt ctggagtgta cacatttcta tccagcacct     1620

tgaagtctct ggaagagaag gaccacatcc accgagtcct ggacaagatc aacgacactt     1680

tgatccactt gatggccaaa gctggcctga ctctgcagca acagcatcgc cgtctggccc     1740

agctcctcct catcctttcc catatccggc acatgagtaa caaaggcatg gagcatctct     1800

acaacatgaa atgcaagaat gtcgtgcctc tctatgacct gctgctggag atgctggatg     1860

ctcatcgtct tcatgccccc gccagtcgca tgggagtgcc cccggaggag cctagccaga     1920

gccagctgac caccaccagc tccacttcag cacattcctt acaaacctac tacatccccc     1980

cggaagcaga gggcttcccc aacaccatct gagaactccc aggctcccca caaggttctg     2040

cgaatccctg aaacgtttta cccatgtcct gtatgacttt agcagaattc                2090


