                         SEQUENCE LISTING

<110>  Silenseed Ltd.
 
<120>  METHODS AND COMPOSITIONS FOR RNAi-BASED CANCER TREATMENT

<130>  SILE 2142/3.2

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  1
guuggagcug auggcg                                                       16


<210>  2
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  2
guuggagcug uuggcg                                                       16


<210>  3
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  3
guuggagcug cuggcg                                                       16


<210>  4
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  4
guuggagcua guggcg                                                       16


<210>  5
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  5
guuggagcuu guggcg                                                       16


<210>  6
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  6
guuggagcug gugacg                                                       16


<210>  7
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  7
guuggagcug guugcg                                                       16


<210>  8
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  8
uaggcaagag ugcc                                                         14


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  9
guuggagcug auggcguag                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  10
guuggagcug uuggcguag                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  11
guuggagcug cuggcguag                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  12
guuggagcua guggcguag                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  13
guuggagcuu guggcguag                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  14
guuggagcug gugacguag                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  15
guuggagcug guugcguag                                                    19


<210>  16
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  16
guuggagcug auggcgu                                                      17


<210>  17
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  17
guuggagcug auggcgua                                                     18


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  18
guuggagcug auggcguag                                                    19


<210>  19
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  19
guuggagcug auggcguagg                                                   20


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  20
guuggagcug auggcguagg c                                                 21


<210>  21
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  21
guuggagcug auggcguagg ca                                                22


<210>  22
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  22
guuggagcug auggcguagg caa                                               23


<210>  23
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  23
guuggagcug auggcguagg caag                                              24


<210>  24
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  24
guuggagcug auggcguagg caaga                                             25


<210>  25
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  25
guuggagcug auggcguagg caagag                                            26


<210>  26
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  26
guuggagcug auggcguagg caagagu                                           27


<210>  27
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  27
guuggagcug auggcguagg caagagug                                          28


<210>  28
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  28
guuggagcug auggcguagg caagagugc                                         29


<210>  29
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  29
guuggagcug auggcguagg caagagugcc                                        30


<210>  30
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  30
cgccaucagc uccaac                                                       16


<210>  31
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  31
cgccaacagc uccaac                                                       16


<210>  32
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  32
cgccagcagc uccaac                                                       16


<210>  33
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  33
cgccacuagc uccaac                                                       16


<210>  34
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  34
cgccacaagc uccaac                                                       16


<210>  35
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  35
cgucaccagc uccaac                                                       16


<210>  36
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  36
cgcaaccagc uccaac                                                       16


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(4)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  37
guuggagcug auggcguagt t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  38
cuacgccauc agcuccaact t                                                 21


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2-OMe
<222>  (3)..(3)

<220>
<221>  2-OMe
<222>  (9)..(9)

<220>
<221>  2-OMe
<222>  (12)..(12)

<220>
<221>  2-OMe
<222>  (17)..(17)

<400>  39
guuggagcug auggcguag                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2-OMe
<222>  (2)..(2)

<220>
<221>  2-OMe
<222>  (7)..(7)

<220>
<221>  2-OMe
<222>  (10)..(10)

<220>
<221>  2-OMe
<222>  (16)..(16)

<400>  40
cuacgccauc agcuccaac                                                    19


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  41
guuggagcug auggcguagt t                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  42
cuacgccauc agcuccaact t                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2-OMe
<222>  (3)..(3)

<220>
<221>  2-OMe
<222>  (9)..(9)

<220>
<221>  2-OMe
<222>  (12)..(12)

<220>
<221>  2-OMe
<222>  (17)..(17)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  43
guuggagcug auggcguagt t                                                 21


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (2)..(2)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (10)..(10)

<220>
<221>  2'-OMe
<222>  (16)..(16)

<400>  44
cuacgccauc agcuccaact t                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(10)

<220>
<221>  2'-OMe
<222>  (12)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  45
guuggagcug auggcguagt t                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (2)..(2)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (10)..(10)

<220>
<221>  2'-OMe
<222>  (16)..(16)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  46
cuacgccauc agcuccaact t                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(10)

<220>
<221>  2'-OMe
<222>  (12)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  47
guuggagcug auggcguagt t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  48
cuacgccauc agcuccaact t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(4)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  49
guuggagcug auggcguagt t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(3)

<220>
<221>  2'-OMe
<222>  (18)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  50
cuacgccauc agcuccaact t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(4)

<220>
<221>  2'-OMe
<222>  (13)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  51
guuggagcug auggcguagt t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(3)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (18)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  52
cuacgccauc agcuccaact t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (2)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(10)

<220>
<221>  2'-OMe
<222>  (12)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  53
guuggagcug auggcguagt t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  54
cuacgccauc agcuccaact t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (1)..(1)

<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (3)..(3)

<220>
<221>  2'-OMe
<222>  (5)..(5)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (9)..(9)

<220>
<221>  2'-OMe
<222>  (11)..(11)

<220>
<221>  2'-OMe
<222>  (13)..(13)

<220>
<221>  2'-OMe
<222>  (15)..(15)

<220>
<221>  2'-OMe
<222>  (17)..(17)

<220>
<221>  2'-OMe
<222>  (19)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  55
guuggagcug auggcguagt t                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  2'-OMe
<222>  (2)..(2)

<220>
<221>  2'-OMe
<222>  (4)..(4)

<220>
<221>  2'-OMe
<222>  (6)..(6)

<220>
<221>  2'-OMe
<222>  (8)..(8)

<220>
<221>  2'-OMe
<222>  (14)..(14)

<220>
<221>  2'-OMe
<222>  (16)..(16)

<220>
<221>  2'-OMe
<222>  (18)..(18)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  56
cuacgccauc agcuccaact t                                                 21


<210>  57
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (1)..(1)

<220>
<221>  2'-OMe
<222>  (3)..(3)

<220>
<221>  2'-OMe
<222>  (5)..(5)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (9)..(9)

<220>
<221>  2'-OMe
<222>  (11)..(11)

<220>
<221>  2'-OMe
<222>  (13)..(13)

<220>
<221>  2'-OMe
<222>  (15)..(15)

<220>
<221>  2'-OMe
<222>  (17)..(17)

<220>
<221>  2'-OMe
<222>  (19)..(19)

<400>  57
guuggagcug auggcguag                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (2)..(2)

<220>
<221>  2'-OMe
<222>  (4)..(4)

<220>
<221>  2'-OMe
<222>  (6)..(6)

<220>
<221>  2'-OMe
<222>  (8)..(8)

<220>
<221>  2'-OMe
<222>  (14)..(14)

<220>
<221>  2'-OMe
<222>  (16)..(16)

<220>
<221>  2'-OMe
<222>  (18)..(18)

<400>  58
cuacgccauc agcuccaac                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (2)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<400>  59
guuggagcug auggcguag                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  60
cuacgccauc agcuccaac                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (2)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(13)

<400>  61
guuggagcug auggcguag                                                    19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  62
cuacgccauc agcuccaac                                                    19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (1)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(13)

<220>
<221>  2'-OMe
<222>  (19)..(19)

<400>  63
guuggagcug auggcguag                                                    19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence

<400>  64
cuacgccauc agcuccaac                                                    19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (1)..(3)

<220>
<221>  2'-OMe
<222>  (9)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(19)

<400>  65
guuggagcug auggcguag                                                    19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (4)..(6)

<220>
<221>  2'-OMe
<222>  (14)..(16)

<400>  66
cuacgccauc agcuccaac                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (2)..(4)

<220>
<221>  2'-OMe
<222>  (9)..(10)

<220>
<221>  2'-OMe
<222>  (12)..(13)

<220>
<221>  2'-OMe
<222>  (17)..(18)

<400>  67
guuggagcug auggcguag                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sequence


<220>
<221>  2'-OMe
<222>  (2)..(2)

<220>
<221>  2'-OMe
<222>  (7)..(7)

<220>
<221>  2'-OMe
<222>  (16)..(16)

<400>  68
cuacgccauc agcuccaac                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  69
guuugcaaga ucugcggca                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  70
cuggucaaga agcauuuca                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  71
gucugcagcu cucgcccaa                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  72
ggugugcguc cagccguug                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  73
gacucgagca uuuagacac                                                    19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  74
cagguguaag cgcagaaag                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  75
gucauuagaa gaggcguaa                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  76
cauuagaaga ggcguaaca                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  77
guacaauaug agagcagug                                                    19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  78
cagcuggacu ugaucgaga                                                    19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  79
cacugauugc acuucugag                                                    19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  80
gucuaacggu uuccccuaa                                                    19


<210>  81
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  81
gagaaauugc aggaggag                                                     18


<210>  82
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand

<400>  82
cagaugucaa gaaguacca                                                    19


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA sense strand


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA nucleotides

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA nucleotides

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxythymidine

<400>  83
guuugcaaga ucugcggcat t                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA antisense strand


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA nucleotides

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA nucleotides

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  deoxythymidine

<400>  84
ugccgcagau cuugcaaact t                                                 21


