                         SEQUENCE LISTING

<110>  Tel HaShomer Medical Research Infrastructure and Services 
       Ltd.
       WOLF, Ido
       RUBINEK, Tamar
 
<120>  KLOTHO VARIANT POLYPEPTIDES AND USES THEREOF IN THERAPY

<130>  117'27a

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  1012
<212>  PRT
<213>  Homo_sapiens

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  1

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  2
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  residues 29-102 of SEQ ID NO:1

<400>  2

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe 
945                 950                 955                 960 


Leu Phe Phe Ala Ser Ile Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser 
                965                 970                 975     


Lys Lys Gly Arg Arg Ser Tyr Lys 
            980                 


<210>  3
<211>  980
<212>  PRT
<213>  Artificial

<220>
<223>  residues 1-980 of SEQ ID NO:1

<400>  3

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys 
            980 


<210>  4
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  residues 29-980 of SEQ ID NO:1

<400>  4

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys 
945                 950         


<210>  5
<211>  568
<212>  PRT
<213>  Artificial

<220>
<223>   residues 1-568 of SEQ ID NO:1

<400>  5

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg 
                565             


<210>  6
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  residues 29-568 of SEQ ID NO:1

<400>  6

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
    530                 535                 540 


<210>  7
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>   residues 34-549 of SEQ ID NO:1

<400>  7

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  8
<211>  549
<212>  PRT
<213>  Homo sapiens

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  8

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  9
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>   residues 29-549 of SEQ ID NO:8

<400>  9

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro 
            500                 505                 510         


Ile Ser Ser Leu Thr Lys Pro Tyr His 
        515                 520     


<210>  10
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  residues 34-549 of SEQ ID NO:8

<400>  10

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  11
<211>  1012
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  12
<211>  942
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (344)..(344)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly Lys Gly 
1               5                   10                  15      


Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala Pro Pro Gly 
            20                  25                  30          


Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln 
        35                  40                  45              


Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg 
    50                  55                  60                  


Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val Pro Asn 
                85                  90                  95      


Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu 
            100                 105                 110         


Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu Pro Gln 
        115                 120                 125             


Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp 
    130                 135                 140                 


His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly Gly Gln 
145                 150                 155                 160 


Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala Trp His 
                165                 170                 175     


Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg 
            180                 185                 190         


Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala Lys Val 
        195                 200                 205             


Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly Gln Val 
    210                 215                 220                 


Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met Thr Asp 
225                 230                 235                 240 


His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu Gly Trp 
                245                 250                 255     


Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys 
            260                 265                 270         


Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys 
        275                 280                 285             


Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr 
    290                 295                 300                 


Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln Leu Glu 
305                 310                 315                 320 


Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn 
                325                 330                 335     


His Pro Gln Ile Phe Ile Val Xaa Asn Gly Trp Phe Val Ser Gly Thr 
            340                 345                 350         


Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile 
        355                 360                 365             


Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val Ile Gly 
    370                 375                 380                 


Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg Gly Tyr 
385                 390                 395                 400 


Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys 
                405                 410                 415     


Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu 
            420                 425                 430         


Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr 
        435                 440                 445             


Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val 
    450                 455                 460                 


Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp 
465                 470                 475                 480 


Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val Val Thr Lys 
                485                 490                 495     


Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile 
            500                 505                 510         


Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp 
        515                 520                 525             


Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr 
    530                 535                 540                 


Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn 
545                 550                 555                 560 


Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly 
                565                 570                 575     


Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr 
            580                 585                 590         


Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly 
        595                 600                 605             


His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn 
    610                 615                 620                 


Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala 
625                 630                 635                 640 


Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile 
                645                 650                 655     


Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser 
            660                 665                 670         


Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly 
        675                 680                 685             


Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met 
    690                 695                 700                 


Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr 
705                 710                 715                 720 


Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu 
                725                 730                 735     


Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile 
            740                 745                 750         


Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp 
        755                 760                 765             


Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys 
    770                 775                 780                 


Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile 
785                 790                 795                 800 


Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu 
                805                 810                 815     


Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His 
            820                 825                 830         


Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn 
        835                 840                 845             


Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln 
    850                 855                 860                 


Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser 
865                 870                 875                 880 


Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu 
                885                 890                 895     


Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg Lys Ser Leu 
            900                 905                 910         


Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala Ser Ile Ile Ser Leu Ser 
        915                 920                 925             


Leu Ile Phe Tyr Tyr Ser Lys Lys Gly Arg Arg Ser Tyr Lys 
    930                 935                 940         


<210>  13
<211>  980
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys 
            980 


<210>  14
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys 
945                 950         


<210>  15
<211>  568
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg 
                565             


<210>  16
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
    530                 535                 540 


<210>  17
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (381)..(381)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  18
<211>  549
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  19
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro 
            500                 505                 510         


Ile Ser Ser Leu Thr Lys Pro Tyr His 
        515                 520     


<210>  20
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (381)..(381)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  21
<211>  1012
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  22
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe 
945                 950                 955                 960 


Leu Phe Phe Ala Ser Ile Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser 
                965                 970                 975     


Lys Lys Gly Arg Arg Ser Tyr Lys 
            980                 


<210>  23
<211>  980
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys 
            980 


<210>  24
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys 
945                 950         


<210>  25
<211>  568
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg 
                565             


<210>  26
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
    530                 535                 540 


<210>  27
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (205)..(205)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  28
<211>  549
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  29
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro 
            500                 505                 510         


Ile Ser Ser Leu Thr Lys Pro Tyr His 
        515                 520     


<210>  30
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  misc_feature
<222>  (205)..(205)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  31
<211>  1012
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  L-Asp of residue 238 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (414)..(414)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  31

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  32
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  L-Asp of residue 210 is substituted with an a pha-amino acid 
       residue different from L-Glu

<220>
<221>  MOD_RES
<222>  (386)..(386)
<223>  L-Glu of residue 386 is substituted with an alpha-amino acid 
       different from L-Glu.

<400>  32

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe 
945                 950                 955                 960 


Leu Phe Phe Ala Ser Ile Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser 
                965                 970                 975     


Lys Lys Gly Arg Arg Ser Tyr Lys 
            980                 


<210>  33
<211>  980
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  L-Asp of residue 238 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (414)..(414)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  33

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glx Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys 
            980 


<210>  34
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  L-Asp of residue 238 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  L-Asp of residue 210 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (414)..(414)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  34

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys 
945                 950         


<210>  35
<211>  568
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  L-Asp of residue 238 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (414)..(414)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  35

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg 
                565             


<210>  36
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  L-Asp of residue 210 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (386)..(386)
<223>  L-Glu of residue 386 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  36

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Xaa Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg 
    530                 535                 540 


<210>  37
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (205)..(205)
<223>  L-Asp of residue 205 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (381)..(381)
<223>  L-Glu of residue 381 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  37

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  38
<211>  549
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (238)..(238)
<223>  L-Asp of residue 238 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (414)..(414)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  38

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Xaa Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  39
<211>  521
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (210)..(210)
<223>  L-Asp of residue 210 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (386)..(386)
<223>  L-Glu of residue 414 is substituted with ana lpha-amino acid 
       residue different from L-Glu

<400>  39

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Xaa Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glx Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro 
            500                 505                 510         


Ile Ser Ser Leu Thr Lys Pro Tyr His 
        515                 520     


<210>  40
<211>  516
<212>  PRT
<213>  Artificial

<220>
<223>  variant polypeptide


<220>
<221>  MOD_RES
<222>  (205)..(205)
<223>  L-Asp of residue 205 is substituted with an alpha-amino acid 
       different from L-Asp.

<220>
<221>  MOD_RES
<222>  (381)..(381)
<223>  L-Glu of residue 381 is substituted with an alpha-amino acid 
       residue different from L-Glu

<400>  40

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Xaa Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glx Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  41
<211>  3036
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  41
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaa                               3036


<210>  42
<211>  2949
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  42
cgcctgcgtg cggagccggg cgacggcgcg cagacctggg cccgtgtctc gcggcctcct       60

gcccccgagg ccgcgggcct cttccagggc accttccccg acggcttcct ctgggccgtg      120

ggcagcgccg cctaccagac cgagggcggc tggcagcagc acggcaaggg tgcgtccatc      180

tgggacacgt tcacccacca ccccctggca cccccgggag actcccggaa cgccagtctg      240

ccgttgggcg ccccgtcgcc gctgcagccc gccaccgggg acgtagccag cgacagctac      300

aacaacgtct tccgcgacac ggaggcgctg cgcgagctcg gggtcactca ctaccgcttc      360

tccatctcgt gggcgcgagt gctccccaat ggcagcgcgg gcgtccccaa ccgcgagggg      420

ctgcgctact accggcgcct gctggagcgg ctgcgggagc tgggcgtgca gcccgtggtc      480

accctgtacc actgggacct gccccagcgc ctgcaggacg cctacggcgg ctgggccaac      540

cgcgccctgg ccgaccactt cagggattac gcggagctct gcttccgcca cttcggcggt      600

caggtcaagt actggatcac catcgacaac ccctacgtgg tggcctggca cggctacgcc      660

accgggcgcc tggcccccgg catccggggc agcccgcggc tcgggtacct ggtggcgcac      720

aacctcctcc tggctcatgc caaagtctgg catctctaca atacttcttt ccgtcccact      780

cagggaggtc aggtgtccat tgccctaagc tctcactgga tcaatcctcg aagaatgacc      840

gaccacagca tcaaagaatg tcaaaaatct ctggactttg tactaggttg gtttgccaaa      900

cccgtattta ttgatggtga ctatcccgag agcatgaaga ataacctttc atctattctg      960

cctgatttta ctgaatctga gaaaaagttc atcaaaggaa ctgctgactt ttttgctctt     1020

tgctttggac ccaccttgag ttttcaactt ttggaccctc acatgaagtt ccgccaattg     1080

gaatctccca acctgaggca actgctttcc tggattgacc ttgaatttaa ccatcctcaa     1140

atatttattg tggaaaatgg ctggtttgtc tcagggacca ccaagagaga tgatgccaaa     1200

tatatgtatt acctcaaaaa gttcatcatg gaaaccttaa aagccatcaa gctggatggg     1260

gtggatgtca tcgggtatac cgcatggtcc ctcatggatg gtttcgagtg gcacagaggt     1320

tacagcatca ggcgtggact cttctatgtt gactttctaa gccaggacaa gatgttgttg     1380

ccaaagtctt cagccttgtt ctaccaaaag ctgatagaga aaaatggctt ccctccttta     1440

cctgaaaatc agcccctaga agggacattt ccctgtgact ttgcttgggg agttgttgac     1500

aactacattc aagtagatac cactctgtct cagtttaccg acctgaatgt ttacctgtgg     1560

gatgtccacc acagtaaaag gcttattaaa gtggatgggg ttgtgaccaa gaagaggaaa     1620

tcctactgtg ttgactttgc tgccatccag ccccagatcg ctttactcca ggaaatgcac     1680

gttacacatt ttcgcttctc cctggactgg gccctgattc tccctctggg taaccagtcc     1740

caggtgaacc acaccatcct gcagtactat cgctgcatgg ccagcgagct tgtccgtgtc     1800

aacatcaccc cagtggtggc cctgtggcag cctatggccc cgaaccaagg actgccgcgc     1860

ctcctggcca ggcagggcgc ctgggagaac ccctacactg ccctggcctt tgcagagtat     1920

gcccgactgt gctttcaaga gctcggccat cacgtcaagc tttggataac gatgaatgag     1980

ccgtatacaa ggaatatgac atacagtgct ggccacaacc ttctgaaggc ccatgccctg     2040

gcttggcatg tgtacaatga aaagtttagg catgctcaga atgggaaaat atccatagcc     2100

ttgcaggctg attggataga acctgcctgc cctttctccc aaaaggacaa agaggtggcc     2160

gagagagttt tggaatttga cattggctgg ctggctgagc ccattttcgg ctctggagat     2220

tatccatggg tgatgaggga ctggctgaac caaagaaaca attttcttct tccttatttc     2280

actgaagatg aaaaaaagct aatccagggt acctttgact ttttggcttt aagccattat     2340

accaccatcc ttgtagactc agaaaaagaa gatccaataa aatacaatga ttacctagaa     2400

gtgcaagaaa tgaccgacat cacgtggctc aactccccca gtcaggtggc ggtagtgccc     2460

tgggggttgc gcaaagtgct gaactggctg aagttcaagt acggagacct ccccatgtac     2520

ataatatcca acggaatcga tgacgggctg catgctgagg acgaccagct gagggtgtat     2580

tatatgcaga attacataaa cgaagctctc aaagcccaca tactggatgg tatcaatctt     2640

tgcggatact ttgcttattc gtttaacgac cgcacagctc cgaggtttgg cctctatcgt     2700

tatgctgcag atcagtttga gcccaaggca tccatgaaac attacaggaa aattattgac     2760

agcaatggtt tcccgggccc agaaactctg gaaagatttt gtccagaaga attcaccgtg     2820

tgtactgagt gcagtttttt tcacacccga aagtctttac tggctttcat agcttttcta     2880

ttttttgctt ctattatttc tctctccctt atattttact actcgaagaa aggcagaaga     2940

agttacaaa                                                             2949


<210>  43
<211>  2940
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  43
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940


<210>  44
<211>  2857
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  44
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcga caacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtggaaa atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

gaaatcctac tgtgttgact ttgctgccat ccagccccag atcgctttac tccaggaaat     1680

gcacgttaca cattttcgct tctccctgga ctgggccctg attctccctc tgggtaacca     1740

gtcccaggtg aaccacacca tcctgcagta ctatcgctgc atggccagcg agcttgtccg     1800

tgtcaacatc accccagtgg tggccctgtg gcagcctatg gccccgaacc aaggactgcc     1860

gcgcctcctg gccaggcagg gcgcctggga gaacccctac actgccctgg cctttgcaga     1920

gtatgcccga ctgtgctttc aagagctcgg ccatcacgtc aagctttgga taacgatgaa     1980

tgagccgtat acaaggaata tgacatacag tgctggccac aaccttctga aggcccatgc     2040

cctggcttgg catgtgtaca atgaaaagtt taggcatgct cagaatggga aaatatccat     2100

agccttgcag gctgattgga tagaacctgc ctgccctttc tcccaaaagg acaaagaggt     2160

ggccgagaga gttttggaat ttgacattgg ctggctggct gagcccattt tcggctctgg     2220

agattatcca tgggtgatga gggactggct gaaccaaaga aacaattttc ttcttcctta     2280

tttcactgaa gatgaaaaaa agctaatcca gggtaccttt gactttttgg ctttaagcca     2340

ttataccacc atccttgtag actcagaaaa agaagatcca ataaaataca atgattacct     2400

agaagtgcaa gaaatgaccg acatcacgtg gctcaactcc cccagtcagg tggcggtagt     2460

gccctggggg ttgcgcaaag tgctgaactg gctgaagttc aagtacggag acctccccat     2520

gtacataata tccaacggaa tcgatgacgg gctgcatgct gaggacgacc agctgagggt     2580

gtattatatg cagaattaca taaacgaagc tctcaaagcc cacatactgg atggtatcaa     2640

tctttgcgga tactttgctt attcgtttaa cgaccgcaca gctccgaggt ttggcctcta     2700

tcgttatgct gcagatcagt ttgagcccaa ggcatccatg aaacattaca ggaaaattat     2760

tgacagcaat ggtttcccgg gcccagaaac tctggaaaga ttttgtccag aagaattcac     2820

cgtgtgtact gagtgcagtt tttttcacac ccgaaag                              2857


<210>  45
<211>  1704
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  45
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gagg                                            1704


<210>  46
<211>  1621
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  46
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcga caacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtggaaa atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

g                                                                     1621


<210>  47
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  47
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtgg                  1548


<210>  48
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  48
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcac                                         1647


<210>  49
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  49
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcgac aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtggaaaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaag tcagctgaca aaaccaatca gcagtctcac caagccctat     1560

cac                                                                   1563


<210>  50
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide

<400>  50
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtaagtcagc tgacaaaacc aatcagcagt ctcaccaagc cctatcac                  1548


<210>  51
<211>  3036
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  51
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaa                               3036


<210>  52
<211>  2949
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1153)..(1155)
<223>  n is a, c, g, or t

<400>  52
cgcctgcgtg cggagccggg cgacggcgcg cagacctggg cccgtgtctc gcggcctcct       60

gcccccgagg ccgcgggcct cttccagggc accttccccg acggcttcct ctgggccgtg      120

ggcagcgccg cctaccagac cgagggcggc tggcagcagc acggcaaggg tgcgtccatc      180

tgggacacgt tcacccacca ccccctggca cccccgggag actcccggaa cgccagtctg      240

ccgttgggcg ccccgtcgcc gctgcagccc gccaccgggg acgtagccag cgacagctac      300

aacaacgtct tccgcgacac ggaggcgctg cgcgagctcg gggtcactca ctaccgcttc      360

tccatctcgt gggcgcgagt gctccccaat ggcagcgcgg gcgtccccaa ccgcgagggg      420

ctgcgctact accggcgcct gctggagcgg ctgcgggagc tgggcgtgca gcccgtggtc      480

accctgtacc actgggacct gccccagcgc ctgcaggacg cctacggcgg ctgggccaac      540

cgcgccctgg ccgaccactt cagggattac gcggagctct gcttccgcca cttcggcggt      600

caggtcaagt actggatcac catcgacaac ccctacgtgg tggcctggca cggctacgcc      660

accgggcgcc tggcccccgg catccggggc agcccgcggc tcgggtacct ggtggcgcac      720

aacctcctcc tggctcatgc caaagtctgg catctctaca atacttcttt ccgtcccact      780

cagggaggtc aggtgtccat tgccctaagc tctcactgga tcaatcctcg aagaatgacc      840

gaccacagca tcaaagaatg tcaaaaatct ctggactttg tactaggttg gtttgccaaa      900

cccgtattta ttgatggtga ctatcccgag agcatgaaga ataacctttc atctattctg      960

cctgatttta ctgaatctga gaaaaagttc atcaaaggaa ctgctgactt ttttgctctt     1020

tgctttggac ccaccttgag ttttcaactt ttggaccctc acatgaagtt ccgccaattg     1080

gaatctccca acctgaggca actgctttcc tggattgacc ttgaatttaa ccatcctcaa     1140

atatttattg tgnnnaatgg ctggtttgtc tcagggacca ccaagagaga tgatgccaaa     1200

tatatgtatt acctcaaaaa gttcatcatg gaaaccttaa aagccatcaa gctggatggg     1260

gtggatgtca tcgggtatac cgcatggtcc ctcatggatg gtttcgagtg gcacagaggt     1320

tacagcatca ggcgtggact cttctatgtt gactttctaa gccaggacaa gatgttgttg     1380

ccaaagtctt cagccttgtt ctaccaaaag ctgatagaga aaaatggctt ccctccttta     1440

cctgaaaatc agcccctaga agggacattt ccctgtgact ttgcttgggg agttgttgac     1500

aactacattc aagtagatac cactctgtct cagtttaccg acctgaatgt ttacctgtgg     1560

gatgtccacc acagtaaaag gcttattaaa gtggatgggg ttgtgaccaa gaagaggaaa     1620

tcctactgtg ttgactttgc tgccatccag ccccagatcg ctttactcca ggaaatgcac     1680

gttacacatt ttcgcttctc cctggactgg gccctgattc tccctctggg taaccagtcc     1740

caggtgaacc acaccatcct gcagtactat cgctgcatgg ccagcgagct tgtccgtgtc     1800

aacatcaccc cagtggtggc cctgtggcag cctatggccc cgaaccaagg actgccgcgc     1860

ctcctggcca ggcagggcgc ctgggagaac ccctacactg ccctggcctt tgcagagtat     1920

gcccgactgt gctttcaaga gctcggccat cacgtcaagc tttggataac gatgaatgag     1980

ccgtatacaa ggaatatgac atacagtgct ggccacaacc ttctgaaggc ccatgccctg     2040

gcttggcatg tgtacaatga aaagtttagg catgctcaga atgggaaaat atccatagcc     2100

ttgcaggctg attggataga acctgcctgc cctttctccc aaaaggacaa agaggtggcc     2160

gagagagttt tggaatttga cattggctgg ctggctgagc ccattttcgg ctctggagat     2220

tatccatggg tgatgaggga ctggctgaac caaagaaaca attttcttct tccttatttc     2280

actgaagatg aaaaaaagct aatccagggt acctttgact ttttggcttt aagccattat     2340

accaccatcc ttgtagactc agaaaaagaa gatccaataa aatacaatga ttacctagaa     2400

gtgcaagaaa tgaccgacat cacgtggctc aactccccca gtcaggtggc ggtagtgccc     2460

tgggggttgc gcaaagtgct gaactggctg aagttcaagt acggagacct ccccatgtac     2520

ataatatcca acggaatcga tgacgggctg catgctgagg acgaccagct gagggtgtat     2580

tatatgcaga attacataaa cgaagctctc aaagcccaca tactggatgg tatcaatctt     2640

tgcggatact ttgcttattc gtttaacgac cgcacagctc cgaggtttgg cctctatcgt     2700

tatgctgcag atcagtttga gcccaaggca tccatgaaac attacaggaa aattattgac     2760

agcaatggtt tcccgggccc agaaactctg gaaagatttt gtccagaaga attcaccgtg     2820

tgtactgagt gcagtttttt tcacacccga aagtctttac tggctttcat agcttttcta     2880

ttttttgctt ctattatttc tctctccctt atattttact actcgaagaa aggcagaaga     2940

agttacaaa                                                             2949


<210>  53
<211>  2940
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  53
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940


<210>  54
<211>  2857
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1157)..(1159)
<223>  n is a, c, g, or t

<400>  54
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcga caacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtgnnna atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

gaaatcctac tgtgttgact ttgctgccat ccagccccag atcgctttac tccaggaaat     1680

gcacgttaca cattttcgct tctccctgga ctgggccctg attctccctc tgggtaacca     1740

gtcccaggtg aaccacacca tcctgcagta ctatcgctgc atggccagcg agcttgtccg     1800

tgtcaacatc accccagtgg tggccctgtg gcagcctatg gccccgaacc aaggactgcc     1860

gcgcctcctg gccaggcagg gcgcctggga gaacccctac actgccctgg cctttgcaga     1920

gtatgcccga ctgtgctttc aagagctcgg ccatcacgtc aagctttgga taacgatgaa     1980

tgagccgtat acaaggaata tgacatacag tgctggccac aaccttctga aggcccatgc     2040

cctggcttgg catgtgtaca atgaaaagtt taggcatgct cagaatggga aaatatccat     2100

agccttgcag gctgattgga tagaacctgc ctgccctttc tcccaaaagg acaaagaggt     2160

ggccgagaga gttttggaat ttgacattgg ctggctggct gagcccattt tcggctctgg     2220

agattatcca tgggtgatga gggactggct gaaccaaaga aacaattttc ttcttcctta     2280

tttcactgaa gatgaaaaaa agctaatcca gggtaccttt gactttttgg ctttaagcca     2340

ttataccacc atccttgtag actcagaaaa agaagatcca ataaaataca atgattacct     2400

agaagtgcaa gaaatgaccg acatcacgtg gctcaactcc cccagtcagg tggcggtagt     2460

gccctggggg ttgcgcaaag tgctgaactg gctgaagttc aagtacggag acctccccat     2520

gtacataata tccaacggaa tcgatgacgg gctgcatgct gaggacgacc agctgagggt     2580

gtattatatg cagaattaca taaacgaagc tctcaaagcc cacatactgg atggtatcaa     2640

tctttgcgga tactttgctt attcgtttaa cgaccgcaca gctccgaggt ttggcctcta     2700

tcgttatgct gcagatcagt ttgagcccaa ggcatccatg aaacattaca ggaaaattat     2760

tgacagcaat ggtttcccgg gcccagaaac tctggaaaga ttttgtccag aagaattcac     2820

cgtgtgtact gagtgcagtt tttttcacac ccgaaag                              2857


<210>  55
<211>  1704
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  55
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gagg                                            1704


<210>  56
<211>  1621
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1157)..(1159)
<223>  n is a, c, g, or t

<400>  56
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcga caacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtgnnna atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

g                                                                     1621


<210>  57
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1141)..(1143)
<223>  n is a, c, g, or t

<400>  57
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

nnnaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtgg                  1548


<210>  58
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  58
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcac                                         1647


<210>  59
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1156)..(1158)
<223>  n is a, c, g, or t

<400>  59
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcgac aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtgnnnaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaag tcagctgaca aaaccaatca gcagtctcac caagccctat     1560

cac                                                                   1563


<210>  60
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (1141)..(1143)
<223>  n is a, c, g, or t

<400>  60
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

nnnaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtaagtcagc tgacaaaacc aatcagcagt ctcaccaagc cctatcac                  1548


<210>  61
<211>  3036
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<400>  61
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaa                               3036


<210>  62
<211>  2949
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (625)..(627)
<223>  n is a, c, g, or t

<400>  62
cgcctgcgtg cggagccggg cgacggcgcg cagacctggg cccgtgtctc gcggcctcct       60

gcccccgagg ccgcgggcct cttccagggc accttccccg acggcttcct ctgggccgtg      120

ggcagcgccg cctaccagac cgagggcggc tggcagcagc acggcaaggg tgcgtccatc      180

tgggacacgt tcacccacca ccccctggca cccccgggag actcccggaa cgccagtctg      240

ccgttgggcg ccccgtcgcc gctgcagccc gccaccgggg acgtagccag cgacagctac      300

aacaacgtct tccgcgacac ggaggcgctg cgcgagctcg gggtcactca ctaccgcttc      360

tccatctcgt gggcgcgagt gctccccaat ggcagcgcgg gcgtccccaa ccgcgagggg      420

ctgcgctact accggcgcct gctggagcgg ctgcgggagc tgggcgtgca gcccgtggtc      480

accctgtacc actgggacct gccccagcgc ctgcaggacg cctacggcgg ctgggccaac      540

cgcgccctgg ccgaccactt cagggattac gcggagctct gcttccgcca cttcggcggt      600

caggtcaagt actggatcac catcnnnaac ccctacgtgg tggcctggca cggctacgcc      660

accgggcgcc tggcccccgg catccggggc agcccgcggc tcgggtacct ggtggcgcac      720

aacctcctcc tggctcatgc caaagtctgg catctctaca atacttcttt ccgtcccact      780

cagggaggtc aggtgtccat tgccctaagc tctcactgga tcaatcctcg aagaatgacc      840

gaccacagca tcaaagaatg tcaaaaatct ctggactttg tactaggttg gtttgccaaa      900

cccgtattta ttgatggtga ctatcccgag agcatgaaga ataacctttc atctattctg      960

cctgatttta ctgaatctga gaaaaagttc atcaaaggaa ctgctgactt ttttgctctt     1020

tgctttggac ccaccttgag ttttcaactt ttggaccctc acatgaagtt ccgccaattg     1080

gaatctccca acctgaggca actgctttcc tggattgacc ttgaatttaa ccatcctcaa     1140

atatttattg tggaaaatgg ctggtttgtc tcagggacca ccaagagaga tgatgccaaa     1200

tatatgtatt acctcaaaaa gttcatcatg gaaaccttaa aagccatcaa gctggatggg     1260

gtggatgtca tcgggtatac cgcatggtcc ctcatggatg gtttcgagtg gcacagaggt     1320

tacagcatca ggcgtggact cttctatgtt gactttctaa gccaggacaa gatgttgttg     1380

ccaaagtctt cagccttgtt ctaccaaaag ctgatagaga aaaatggctt ccctccttta     1440

cctgaaaatc agcccctaga agggacattt ccctgtgact ttgcttgggg agttgttgac     1500

aactacattc aagtagatac cactctgtct cagtttaccg acctgaatgt ttacctgtgg     1560

gatgtccacc acagtaaaag gcttattaaa gtggatgggg ttgtgaccaa gaagaggaaa     1620

tcctactgtg ttgactttgc tgccatccag ccccagatcg ctttactcca ggaaatgcac     1680

gttacacatt ttcgcttctc cctggactgg gccctgattc tccctctggg taaccagtcc     1740

caggtgaacc acaccatcct gcagtactat cgctgcatgg ccagcgagct tgtccgtgtc     1800

aacatcaccc cagtggtggc cctgtggcag cctatggccc cgaaccaagg actgccgcgc     1860

ctcctggcca ggcagggcgc ctgggagaac ccctacactg ccctggcctt tgcagagtat     1920

gcccgactgt gctttcaaga gctcggccat cacgtcaagc tttggataac gatgaatgag     1980

ccgtatacaa ggaatatgac atacagtgct ggccacaacc ttctgaaggc ccatgccctg     2040

gcttggcatg tgtacaatga aaagtttagg catgctcaga atgggaaaat atccatagcc     2100

ttgcaggctg attggataga acctgcctgc cctttctccc aaaaggacaa agaggtggcc     2160

gagagagttt tggaatttga cattggctgg ctggctgagc ccattttcgg ctctggagat     2220

tatccatggg tgatgaggga ctggctgaac caaagaaaca attttcttct tccttatttc     2280

actgaagatg aaaaaaagct aatccagggt acctttgact ttttggcttt aagccattat     2340

accaccatcc ttgtagactc agaaaaagaa gatccaataa aatacaatga ttacctagaa     2400

gtgcaagaaa tgaccgacat cacgtggctc aactccccca gtcaggtggc ggtagtgccc     2460

tgggggttgc gcaaagtgct gaactggctg aagttcaagt acggagacct ccccatgtac     2520

ataatatcca acggaatcga tgacgggctg catgctgagg acgaccagct gagggtgtat     2580

tatatgcaga attacataaa cgaagctctc aaagcccaca tactggatgg tatcaatctt     2640

tgcggatact ttgcttattc gtttaacgac cgcacagctc cgaggtttgg cctctatcgt     2700

tatgctgcag atcagtttga gcccaaggca tccatgaaac attacaggaa aattattgac     2760

agcaatggtt tcccgggccc agaaactctg gaaagatttt gtccagaaga attcaccgtg     2820

tgtactgagt gcagtttttt tcacacccga aagtctttac tggctttcat agcttttcta     2880

ttttttgctt ctattatttc tctctccctt atattttact actcgaagaa aggcagaaga     2940

agttacaaa                                                             2949


<210>  63
<211>  2940
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<400>  63
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940


<210>  64
<211>  2857
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (629)..(631)
<223>  n is a, c, g, or t

<400>  64
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcnn naacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtggaaa atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

gaaatcctac tgtgttgact ttgctgccat ccagccccag atcgctttac tccaggaaat     1680

gcacgttaca cattttcgct tctccctgga ctgggccctg attctccctc tgggtaacca     1740

gtcccaggtg aaccacacca tcctgcagta ctatcgctgc atggccagcg agcttgtccg     1800

tgtcaacatc accccagtgg tggccctgtg gcagcctatg gccccgaacc aaggactgcc     1860

gcgcctcctg gccaggcagg gcgcctggga gaacccctac actgccctgg cctttgcaga     1920

gtatgcccga ctgtgctttc aagagctcgg ccatcacgtc aagctttgga taacgatgaa     1980

tgagccgtat acaaggaata tgacatacag tgctggccac aaccttctga aggcccatgc     2040

cctggcttgg catgtgtaca atgaaaagtt taggcatgct cagaatggga aaatatccat     2100

agccttgcag gctgattgga tagaacctgc ctgccctttc tcccaaaagg acaaagaggt     2160

ggccgagaga gttttggaat ttgacattgg ctggctggct gagcccattt tcggctctgg     2220

agattatcca tgggtgatga gggactggct gaaccaaaga aacaattttc ttcttcctta     2280

tttcactgaa gatgaaaaaa agctaatcca gggtaccttt gactttttgg ctttaagcca     2340

ttataccacc atccttgtag actcagaaaa agaagatcca ataaaataca atgattacct     2400

agaagtgcaa gaaatgaccg acatcacgtg gctcaactcc cccagtcagg tggcggtagt     2460

gccctggggg ttgcgcaaag tgctgaactg gctgaagttc aagtacggag acctccccat     2520

gtacataata tccaacggaa tcgatgacgg gctgcatgct gaggacgacc agctgagggt     2580

gtattatatg cagaattaca taaacgaagc tctcaaagcc cacatactgg atggtatcaa     2640

tctttgcgga tactttgctt attcgtttaa cgaccgcaca gctccgaggt ttggcctcta     2700

tcgttatgct gcagatcagt ttgagcccaa ggcatccatg aaacattaca ggaaaattat     2760

tgacagcaat ggtttcccgg gcccagaaac tctggaaaga ttttgtccag aagaattcac     2820

cgtgtgtact gagtgcagtt tttttcacac ccgaaag                              2857


<210>  65
<211>  1704
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<400>  65
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gagg                                            1704


<210>  66
<211>  1621
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (629)..(631)
<223>  n is a, c, g, or t

<400>  66
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcnn naacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtggaaa atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

g                                                                     1621


<210>  67
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant polypeptide


<220>
<221>  misc_feature
<222>  (613)..(615)
<223>  n is a, c, g, or t

<400>  67
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcnnnaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtgg                  1548


<210>  68
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<400>  68
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcac                                         1647


<210>  69
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (628)..(630)
<223>  n is a, c, g, or t

<400>  69
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcnnn aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtggaaaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaag tcagctgaca aaaccaatca gcagtctcac caagccctat     1560

cac                                                                   1563


<210>  70
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (613)..(615)
<223>  n is a, c, g, or t

<400>  70
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcnnnaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtaagtcagc tgacaaaacc aatcagcagt ctcaccaagc cctatcac                  1548


<210>  71
<211>  3036
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  71
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaa                               3036


<210>  72
<211>  2949
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (625)..(627)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1153)..(1155)
<223>  n is a, c, g, or t

<400>  72
cgcctgcgtg cggagccggg cgacggcgcg cagacctggg cccgtgtctc gcggcctcct       60

gcccccgagg ccgcgggcct cttccagggc accttccccg acggcttcct ctgggccgtg      120

ggcagcgccg cctaccagac cgagggcggc tggcagcagc acggcaaggg tgcgtccatc      180

tgggacacgt tcacccacca ccccctggca cccccgggag actcccggaa cgccagtctg      240

ccgttgggcg ccccgtcgcc gctgcagccc gccaccgggg acgtagccag cgacagctac      300

aacaacgtct tccgcgacac ggaggcgctg cgcgagctcg gggtcactca ctaccgcttc      360

tccatctcgt gggcgcgagt gctccccaat ggcagcgcgg gcgtccccaa ccgcgagggg      420

ctgcgctact accggcgcct gctggagcgg ctgcgggagc tgggcgtgca gcccgtggtc      480

accctgtacc actgggacct gccccagcgc ctgcaggacg cctacggcgg ctgggccaac      540

cgcgccctgg ccgaccactt cagggattac gcggagctct gcttccgcca cttcggcggt      600

caggtcaagt actggatcac catcnnnaac ccctacgtgg tggcctggca cggctacgcc      660

accgggcgcc tggcccccgg catccggggc agcccgcggc tcgggtacct ggtggcgcac      720

aacctcctcc tggctcatgc caaagtctgg catctctaca atacttcttt ccgtcccact      780

cagggaggtc aggtgtccat tgccctaagc tctcactgga tcaatcctcg aagaatgacc      840

gaccacagca tcaaagaatg tcaaaaatct ctggactttg tactaggttg gtttgccaaa      900

cccgtattta ttgatggtga ctatcccgag agcatgaaga ataacctttc atctattctg      960

cctgatttta ctgaatctga gaaaaagttc atcaaaggaa ctgctgactt ttttgctctt     1020

tgctttggac ccaccttgag ttttcaactt ttggaccctc acatgaagtt ccgccaattg     1080

gaatctccca acctgaggca actgctttcc tggattgacc ttgaatttaa ccatcctcaa     1140

atatttattg tgnnnaatgg ctggtttgtc tcagggacca ccaagagaga tgatgccaaa     1200

tatatgtatt acctcaaaaa gttcatcatg gaaaccttaa aagccatcaa gctggatggg     1260

gtggatgtca tcgggtatac cgcatggtcc ctcatggatg gtttcgagtg gcacagaggt     1320

tacagcatca ggcgtggact cttctatgtt gactttctaa gccaggacaa gatgttgttg     1380

ccaaagtctt cagccttgtt ctaccaaaag ctgatagaga aaaatggctt ccctccttta     1440

cctgaaaatc agcccctaga agggacattt ccctgtgact ttgcttgggg agttgttgac     1500

aactacattc aagtagatac cactctgtct cagtttaccg acctgaatgt ttacctgtgg     1560

gatgtccacc acagtaaaag gcttattaaa gtggatgggg ttgtgaccaa gaagaggaaa     1620

tcctactgtg ttgactttgc tgccatccag ccccagatcg ctttactcca ggaaatgcac     1680

gttacacatt ttcgcttctc cctggactgg gccctgattc tccctctggg taaccagtcc     1740

caggtgaacc acaccatcct gcagtactat cgctgcatgg ccagcgagct tgtccgtgtc     1800

aacatcaccc cagtggtggc cctgtggcag cctatggccc cgaaccaagg actgccgcgc     1860

ctcctggcca ggcagggcgc ctgggagaac ccctacactg ccctggcctt tgcagagtat     1920

gcccgactgt gctttcaaga gctcggccat cacgtcaagc tttggataac gatgaatgag     1980

ccgtatacaa ggaatatgac atacagtgct ggccacaacc ttctgaaggc ccatgccctg     2040

gcttggcatg tgtacaatga aaagtttagg catgctcaga atgggaaaat atccatagcc     2100

ttgcaggctg attggataga acctgcctgc cctttctccc aaaaggacaa agaggtggcc     2160

gagagagttt tggaatttga cattggctgg ctggctgagc ccattttcgg ctctggagat     2220

tatccatggg tgatgaggga ctggctgaac caaagaaaca attttcttct tccttatttc     2280

actgaagatg aaaaaaagct aatccagggt acctttgact ttttggcttt aagccattat     2340

accaccatcc ttgtagactc agaaaaagaa gatccaataa aatacaatga ttacctagaa     2400

gtgcaagaaa tgaccgacat cacgtggctc aactccccca gtcaggtggc ggtagtgccc     2460

tgggggttgc gcaaagtgct gaactggctg aagttcaagt acggagacct ccccatgtac     2520

ataatatcca acggaatcga tgacgggctg catgctgagg acgaccagct gagggtgtat     2580

tatatgcaga attacataaa cgaagctctc aaagcccaca tactggatgg tatcaatctt     2640

tgcggatact ttgcttattc gtttaacgac cgcacagctc cgaggtttgg cctctatcgt     2700

tatgctgcag atcagtttga gcccaaggca tccatgaaac attacaggaa aattattgac     2760

agcaatggtt tcccgggccc agaaactctg gaaagatttt gtccagaaga attcaccgtg     2820

tgtactgagt gcagtttttt tcacacccga aagtctttac tggctttcat agcttttcta     2880

ttttttgctt ctattatttc tctctccctt atattttact actcgaagaa aggcagaaga     2940

agttacaaa                                                             2949


<210>  73
<211>  2940
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  73
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940


<210>  74
<211>  2857
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (629)..(631)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1157)..(1159)
<223>  n is a, c, g, or t

<400>  74
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcnn naacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtgnnna atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

gaaatcctac tgtgttgact ttgctgccat ccagccccag atcgctttac tccaggaaat     1680

gcacgttaca cattttcgct tctccctgga ctgggccctg attctccctc tgggtaacca     1740

gtcccaggtg aaccacacca tcctgcagta ctatcgctgc atggccagcg agcttgtccg     1800

tgtcaacatc accccagtgg tggccctgtg gcagcctatg gccccgaacc aaggactgcc     1860

gcgcctcctg gccaggcagg gcgcctggga gaacccctac actgccctgg cctttgcaga     1920

gtatgcccga ctgtgctttc aagagctcgg ccatcacgtc aagctttgga taacgatgaa     1980

tgagccgtat acaaggaata tgacatacag tgctggccac aaccttctga aggcccatgc     2040

cctggcttgg catgtgtaca atgaaaagtt taggcatgct cagaatggga aaatatccat     2100

agccttgcag gctgattgga tagaacctgc ctgccctttc tcccaaaagg acaaagaggt     2160

ggccgagaga gttttggaat ttgacattgg ctggctggct gagcccattt tcggctctgg     2220

agattatcca tgggtgatga gggactggct gaaccaaaga aacaattttc ttcttcctta     2280

tttcactgaa gatgaaaaaa agctaatcca gggtaccttt gactttttgg ctttaagcca     2340

ttataccacc atccttgtag actcagaaaa agaagatcca ataaaataca atgattacct     2400

agaagtgcaa gaaatgaccg acatcacgtg gctcaactcc cccagtcagg tggcggtagt     2460

gccctggggg ttgcgcaaag tgctgaactg gctgaagttc aagtacggag acctccccat     2520

gtacataata tccaacggaa tcgatgacgg gctgcatgct gaggacgacc agctgagggt     2580

gtattatatg cagaattaca taaacgaagc tctcaaagcc cacatactgg atggtatcaa     2640

tctttgcgga tactttgctt attcgtttaa cgaccgcaca gctccgaggt ttggcctcta     2700

tcgttatgct gcagatcagt ttgagcccaa ggcatccatg aaacattaca ggaaaattat     2760

tgacagcaat ggtttcccgg gcccagaaac tctggaaaga ttttgtccag aagaattcac     2820

cgtgtgtact gagtgcagtt tttttcacac ccgaaag                              2857


<210>  75
<211>  1704
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  75
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gagg                                            1704


<210>  76
<211>  1621
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (629)..(631)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1157)..(1159)
<223>  n is a, c, g, or t

<400>  76
ccgccgcctg cgtgcggagc cgggcgacgg cgcgcagacc tgggcccgtg tctcgcggcc       60

tcctgccccc gaggccgcgg gcctcttcca gggcaccttc cccgacggct tcctctgggc      120

cgtgggcagc gccgcctacc agaccgaggg cggctggcag cagcacggca agggtgcgtc      180

catctgggac acgttcaccc accaccccct ggcacccccg ggagactccc ggaacgccag      240

tctgccgttg ggcgccccgt cgccgctgca gcccgccacc ggggacgtag ccagcgacag      300

ctacaacaac gtcttccgcg acacggaggc gctgcgcgag ctcggggtca ctcactaccg      360

cttctccatc tcgtgggcgc gagtgctccc caatggcagc gcgggcgtcc ccaaccgcga      420

ggggctgcgc tactaccggc gcctgctgga gcggctgcgg gagctgggcg tgcagcccgt      480

ggtcaccctg taccactggg acctgcccca gcgcctgcag gacgcctacg gcggctgggc      540

caaccgcgcc ctggccgacc acttcaggga ttacgcggag ctctgcttcc gccacttcgg      600

cggtcaggtc aagtactgga tcaccatcnn naacccctac gtggtggcct ggcacggcta      660

cgccaccggg cgcctggccc ccggcatccg gggcagcccg cggctcgggt acctggtggc      720

gcacaacctc ctcctggctc atgccaaagt ctggcatctc tacaatactt ctttccgtcc      780

cactcaggga ggtcaggtgt ccattgccct aagctctcac tggatcaatc ctcgaagaat      840

gaccgaccac agcatcaaag aatgtcaaaa atctctggac tttgtactag gttggtttgc      900

caaacccgta tttattgatg gtgactatcc cgagagcatg aagaataacc tttcatctat      960

tctgcctgat tttactgaat ctgagaaaaa gttcatcaaa ggaactgctg acttttttgc     1020

tctttgcttt ggacccacct tgagttttca acttttggac cctcacatga agttccgcca     1080

attggaatct cccaacctga ggcaactgct ttcctggatt gaccttgaat ttaaccatcc     1140

tcaaatattt attgtgnnna atggctggtt tgtctcaggg accaccaaga gagatgatgc     1200

caaatatatg tattacctca aaaagttcat catggaaacc ttaaaagcca tcaagctgga     1260

tggggtggat gtcatcgggt ataccgcatg gtccctcatg gatggtttcg agtggcacag     1320

aggttacagc atcaggcgtg gactcttcta tgttgacttt ctaagccagg acaagatgtt     1380

gttgccaaag tcttcagcct tgttctacca aaagctgata gagaaaaatg gcttccctcc     1440

tttacctgaa aatcagcccc tagaagggac atttccctgt gactttgctt ggggagttgt     1500

tgacaactac attcaagtag ataccactct gtctcagttt accgacctga atgtttacct     1560

gtgggatgtc caccacagta aaaggcttat taaagtggat ggggttgtga ccaagaagag     1620

g                                                                     1621


<210>  77
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (613)..(615)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1141)..(1143)
<223>  n is a, c, g, or t

<400>  77
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcnnnaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

nnnaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtgg                  1548


<210>  78
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (712)..(714)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1242)
<223>  n is a, c, g, or t

<400>  78
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cnnnaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgn nnaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcac                                         1647


<210>  79
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (628)..(630)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1156)..(1158)
<223>  n is a, c, g, or t

<400>  79
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcnnn aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtgnnnaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaag tcagctgaca aaaccaatca gcagtctcac caagccctat     1560

cac                                                                   1563


<210>  80
<211>  1548
<212>  DNA
<213>  Artificial

<220>
<223>  DNA encoding recombinant variant polypeptide


<220>
<221>  misc_feature
<222>  (613)..(615)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1141)..(1143)
<223>  n is a, c, g, or t

<400>  80
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcnnnaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

nnnaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtaagtcagc tgacaaaacc aatcagcagt ctcaccaagc cctatcac                  1548


<210>  81
<211>  1014
<212>  PRT
<213>  Mouse

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  81

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Asp Thr Thr Leu Ser Gln Phe Thr 
    530                 535                 540                 


Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
545                 550                 555                 560 


Lys Val Asp Gly Val Val Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp 
                565                 570                 575     


Phe Ser Ala Ile Arg Pro Gln Ile Thr Leu Leu Arg Glu Met Arg Val 
            580                 585                 590         


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
        595                 600                 605             


Asn Gln Thr Gln Val Asn His Thr Val Leu His Phe Tyr Arg Cys Met 
    610                 615                 620                 


Ile Ser Glu Leu Val His Ala Asn Ile Thr Pro Val Val Ala Leu Trp 
625                 630                 635                 640 


Gln Pro Ala Ala Pro His Gln Gly Leu Pro His Ala Leu Ala Lys His 
                645                 650                 655     


Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Asp Tyr Ala 
            660                 665                 670         


Asn Leu Cys Phe Lys Glu Leu Gly His Trp Val Asn Leu Trp Ile Thr 
        675                 680                 685             


Met Asn Glu Pro Asn Thr Arg Asn Met Thr Tyr Arg Ala Gly His His 
    690                 695                 700                 


Leu Leu Arg Ala His Ala Leu Ala Trp His Leu Tyr Asp Asp Lys Phe 
705                 710                 715                 720 


Arg Ala Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp 
                725                 730                 735     


Ile Glu Pro Ala Cys Pro Phe Ser Gln Asn Asp Lys Glu Val Ala Glu 
            740                 745                 750         


Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly 
        755                 760                 765             


Ser Gly Asp Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Lys Asn 
    770                 775                 780                 


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Val Arg 
785                 790                 795                 800 


Gly Ser Phe Asp Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val 
                805                 810                 815     


Asp Trp Glu Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val 
            820                 825                 830         


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala 
        835                 840                 845             


Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Arg Phe Lys 
    850                 855                 860                 


Tyr Gly Asp Leu Pro Met Tyr Val Thr Ala Asn Gly Ile Asp Asp Asp 
865                 870                 875                 880 


Pro His Ala Glu Gln Asp Ser Leu Arg Ile Tyr Tyr Ile Lys Asn Tyr 
                885                 890                 895     


Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Asp Ile Asn Leu Cys 
            900                 905                 910         


Gly Tyr Phe Ala Tyr Ser Leu Ser Asp Arg Ser Ala Pro Lys Ser Gly 
        915                 920                 925             


Phe Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys 
    930                 935                 940                 


His Tyr Arg Arg Ile Ile Asp Ser Asn Gly Phe Leu Gly Ser Gly Thr 
945                 950                 955                 960 


Leu Gly Arg Phe Cys Pro Glu Glu Tyr Thr Val Cys Thr Glu Cys Gly 
                965                 970                 975     


Phe Phe Gln Thr Arg Lys Ser Leu Leu Val Phe Ile Ser Phe Leu Val 
            980                 985                 990         


Phe Thr Phe Ile Ile Ser Leu Ala  Leu Ile Phe His Tyr  Ser Lys Lys 
        995                 1000                 1005             


Gly Gln  Arg Ser Tyr Lys 
    1010                 


<210>  82
<211>  550
<212>  PRT
<213>  Mouse

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  82

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Ser Pro Leu Thr Lys Pro Ser Val 
    530                 535                 540                 


Gly Leu Leu Leu Pro His 
545                 550 


<210>  83
<211>  5032
<212>  DNA
<213>  Mouse

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  83
cctcccggct cccgcagcat gctagcccgc gcccctcctc gccgcccgcc gcggctggtg       60

ctgctccgtt tgctgttgct gcatctgctg ctgctcgccc tgcgcgcccg ctgcctgagc      120

gctgagccgg gtcagggcgc gcagacctgg gctcgcttcg cgcgcgctcc tgccccagag      180

gccgctggcc tcctccacga caccttcccc gacggtttcc tctgggcggt aggcagcgcc      240

gcctatcaga ccgagggcgg ctggcgacag cacggcaaag gcgcgtccat ctgggacact      300

ttcacccatc actctggggc ggccccgtcc gactccccga tcgtcgtggc gccgtcgggt      360

gccccgtcgc ctcccctgtc ctccactgga gatgtggcca gcgatagtta caacaacgtc      420

taccgcgaca cagaggggct gcgcgaactg ggggtcaccc actaccgctt ctccatatcg      480

tgggcgcggg tgctccccaa tggcaccgcg ggcactccca accgcgaggg gctgcgctac      540

taccggcggc tgctggagcg gctgcgggag ctgggcgtgc agccggtggt taccctgtac      600

cattgggacc tgccacagcg cctgcaggac acctatggcg gatgggccaa tcgcgccctg      660

gccgaccatt tcagggatta tgccgagctc tgcttccgcc acttcggtgg tcaggtcaag      720

tactggatca ccattgacaa cccctacgtg gtggcctggc acgggtatgc caccgggcgc      780

ctggccccgg gcgtgagggg cagctccagg ctcgggtacc tggttgccca caacctactt      840

ttggctcatg ccaaagtctg gcatctctac aacacctctt tccgccccac acagggaggc      900

cgggtgtcta tcgccttaag ctcccattgg atcaatcctc gaagaatgac tgactataat      960

atcagagaat gccagaagtc tcttgacttt gtgctaggct ggtttgccaa acccatattt     1020

attgatggcg actacccaga gagtatgaag aacaacctct cgtctcttct gcctgatttt     1080

actgaatctg agaagaggct catcagagga actgctgact tttttgctct ctccttcgga     1140

ccaaccttga gctttcagct attggaccct aacatgaagt tccgccaatt ggagtctccc     1200

aacctgaggc agcttctgtc ttggatagat ctggaatata accaccctcc aatatttatt     1260

gtggaaaatg gctggtttgt ctcgggaacc accaaaaggg atgatgccaa atatatgtat     1320

tatctcaaga agttcataat ggaaacctta aaagcaatca gactggatgg ggtcgacgtc     1380

attgggtaca ccgcgtggtc gctcatggac ggtttcgagt ggcatagggg ctacagcatc     1440

cggcgaggac tcttctacgt tgactttctg agtcaggaca aggagctgtt gccaaagtct     1500

tcggccttgt tctaccaaaa gctgatagag gacaatggct ttcctccttt acctgaaaac     1560

cagccccttg aagggacatt tccctgtgac tttgcttggg gagttgttga caactacgtt     1620

caagtggaca ctactctctc tcagtttact gacccgaatg tctatctgtg ggatgtgcat     1680

cacagtaaga ggcttattaa agtagacggg gttgtagcca agaagagaaa accttactgt     1740

gttgatttct ctgccatccg gcctcagata accttacttc gagaaatgcg ggtcacccac     1800

tttcgcttct ccctggactg ggccctgatc ttgcctctgg gtaaccagac ccaagtgaac     1860

cacacggttc tgcacttcta ccgctgcatg atcagcgagc tggtgcacgc caacatcact     1920

ccagtggtgg ccctgtggca gccagcagcc ccgcaccaag gcctgccaca tgcccttgca     1980

aaacatgggg cctgggagaa cccgcacact gctctggcgt ttgcagacta cgcaaacctg     2040

tgttttaaag agttgggtca ctgggtcaat ctctggatca ccatgaacga gccaaacaca     2100

cggaacatga cctatcgtgc cgggcaccac ctcctgagag cccatgcctt ggcttggcat     2160

ctgtacgatg acaagtttag ggcggctcag aaaggcaaaa tatccatcgc cttgcaggct     2220

gactggatag aaccggcctg ccctttctct caaaatgaca aagaagtggc cgagagagtt     2280

ttggaatttg atataggctg gctggcagag cctatttttg gttccggaga ttatccacgt     2340

gtgatgaggg actggctgaa ccaaaaaaac aattttcttt tgccctattt caccgaagat     2400

gaaaaaaagc tagtccgggg ttcctttgac ttcctggcgg tgagtcatta caccaccatt     2460

ctggtagact gggaaaagga ggatccgatg aaatacaacg attacttgga ggtacaggag     2520

atgactgaca tcacatggct caactctccc agtcaggtgg cagtggtgcc ttgggggctg     2580

cgcaaagtgc tcaactggct aaggttcaag tacggagacc tcccgatgta tgtgacagcc     2640

aatggaatcg atgatgaccc ccacgccgag caagactcac tgaggatcta ttatattaag     2700

aattatgtga atgaggctct gaaagcctac gtgttggacg acatcaacct ttgtggctac     2760

tttgcgtatt cacttagtga tcgctcagct cccaagtctg gcttttatcg atatgctgcg     2820

aatcagtttg agcccaaacc atctatgaaa cattacagga gaattattga cagcaatggc     2880

ttcctgggtt ctggaacact gggaaggttt tgtccagaag aatacactgt gtgcaccgaa     2940

tgtggatttt ttcaaacccg gaagtctttg ctggtcttca tctcgtttct tgtttttact     3000

tttattattt ctcttgctct catttttcac tactccaaga aaggccagag aagttataag     3060

taatgtgaac gtctgcctgg ccattcgctt tgggatcaag atgtacacgc cgtcagccgt     3120

ttgcacctct ctgtgttgtg agccgcattc cacacatttc gattctagaa aacccttttt     3180

gtcatgggtg gtagaggttt taaacaggaa ttggtgagaa taaaatattg cagggtgaat     3240

ggtatctgaa tctgctctct ttggtggcaa ttacggaatt atactcacca cagtttctac     3300

agtgccccgg aatggaaggc atagaatacg gtagggataa cagtgccaag cagacagaag     3360

tttaaagaac aactttaggg acttgtttat ccatggccat ttttaaattc actcctgttg     3420

gggagtaaca ctctctcaat taccatctta acacctggac tttacctgat ccagttttac     3480

aaggtgaagt agaaaaatat ccagtaaagg tggccaagag ccctgagtcc agagcagccc     3540

attaagaagc actattccta ccaaatgctg ctaatgtcaa tttacaaata tacttagaaa     3600

gcacattatg gacatttgta ttcttgtgaa tgtttttgag gtgtgcccta aaccccagat     3660

ccttgagggc tttctcttac caactttcct ttcagagcct gcttgttgga gattcttccc     3720

cagccccctt cccctttccc tcttgctctg ccccacctcg ctccacccag cttgctccag     3780

cccaaagatt ctttatttgt ttctcattac cgaaggttgt gagccaccat gtggtttctg     3840

ggatttgaac tcatgacctc cggaggagct gtcatgctct taaccagccc atgttgaaga     3900

ttcttttgat aaatattcac aaaaaataaa gatgagccat gagctgttgg cctcttcgga     3960

agcggaaact gagtgatttg attgaacatc cttttatctt tgaccagacc ttggaatgaa     4020

tgcaatgacc tttcccacag gaagaaggag gagctctcag tcaaactgta aagaatgcct     4080

cttcagaata tgctgtcagt gcttggatgc catgatgttc aactttctta gtcgatccgg     4140

cagcaatcac agtgtgagca cactgggaac ctgtccttgc ggccgccgag atctaccgtg     4200

tgcttctgtg aagaggcttt gacgtagccc ctctttgagc tcttacacca tgctactgac     4260

ttctagaaag gctaattagg tcttcttcta cacctaatac cctaagtctt actgactctc     4320

acgggagaag tctctgtgct acacctgagt ggtcttattg ataaccctga taccagatca     4380

ggcaagataa atccgtcata gcaggcatgg ctacccttgc tgccacaggg tcacagcaca     4440

tagctcatca ccctgttatt cttcatcttg caatgtggta tggttttcct ggtgaatgat     4500

cagcttttgc tgtggtattc tttatacatc tggacttatt attgaaatca aatgctatag     4560

aatcaatagt ttattttatg tctatttttc ttgatcgcag agtaatatat attaattgta     4620

aaaaatttaa gaaacaaaaa ctatatgtaa agaaaaaatt ataatataat acagagatgc     4680

tgctgacagt tcctatgtgt tgtgttttgt atactgagat catgtgatac gtaggcatac     4740

atcttcttgg gtttttttgt ttttgttttt tgttttgttt tgttttgttt tggttttttg     4800

agatagggtt tctctgtata gccctggctg tcctggaact cactttgcag accaggctag     4860

cctcaaactc ttattcattt ttactgaagt aatttttctg tcattagtct tcaagagcaa     4920

aactttaata gttatggaga atattgccag aacagctcaa aactgtttta tttgttggtc     4980

caatttccca ttaattagtt caataataaa tatcatttag aaataaaaaa aa             5032


<210>  84
<211>  1650
<212>  DNA
<213>  Mouse

<300>
<302>  Polypeptide, novel DNA and novel antibody
<310>  US6579850
<311>  1999-06-25
<312>  2003-06-17

<400>  84
atgctagccc gcgcccctcc tcgccgcccg ccgcggctgg tgctgctccg tttgctgttg       60

ctgcatctgc tgctgctcgc cctgcgcgcc cgctgcctga gcgctgagcc gggtcagggc      120

gcgcagacct gggctcgctt cgcgcgcgct cctgccccag aggccgctgg cctcctccac      180

gacaccttcc ccgacggttt cctctgggcg gtaggcagcg ccgcctatca gaccgagggc      240

ggctggcgac agcacggcaa aggcgcgtcc atctgggaca ctttcaccca tcactctggg      300

gcggccccgt ccgactcccc gatcgtcgtg gcgccgtcgg gtgccccgtc gcctcccctg      360

tcctccactg gagatgtggc cagcgatagt tacaacaacg tctaccgcga cacagagggg      420

ctgcgcgaac tgggggtcac ccactaccgc ttctccatat cgtgggcgcg ggtgctcccc      480

aatggcaccg cgggcactcc caaccgcgag gggctgcgct actaccggcg gctgctggag      540

cggctgcggg agctgggcgt gcagccggtg gttaccctgt accattggga cctgccacag      600

cgcctgcagg acacctatgg cggatgggcc aatcgcgccc tggccgacca tttcagggat      660

tatgccgagc tctgcttccg ccacttcggt ggtcaggtca agtactggat caccattgac      720

aacccctacg tggtggcctg gcacgggtat gccaccgggc gcctggcccc gggcgtgagg      780

ggcagctcca ggctcgggta cctggttgcc cacaacctac ttttggctca tgccaaagtc      840

tggcatctct acaacacctc tttccgcccc acacagggag gccgggtgtc tatcgcctta      900

agctcccatt ggatcaatcc tcgaagaatg actgactata atatcagaga atgccagaag      960

tctcttgact ttgtgctagg ctggtttgcc aaacccatat ttattgatgg cgactaccca     1020

gagagtatga agaacaacct ctcgtctctt ctgcctgatt ttactgaatc tgagaagagg     1080

ctcatcagag gaactgctga cttttttgct ctctgcttcg gaccaacctt gagctttcag     1140

ctattggacc ctaacatgaa gttccgccaa ttggagtctc ccaacctgag gcagcttcts     1200

tcttggatag atctggaata taaccaccct ccaatattta ttgtggaaaa tggctggttt     1260

gtctcgggaa ccaccaaaag ggatgatgcc aaatatatgt attatctcaa gaagttcata     1320

atggaaacct taaaagcaat cagactggat ggggtcgacg tcattgggta caccgcgtgg     1380

tcgctcatgg acggtttcga gtggcatagg ggctacagca tccggcgagg actcttctac     1440

gttgactttc tgagtcagga caaggagctg ttgccaaagt cttcggcctt gttctaccaa     1500

aagctgatag aggacaatgg ctttcctcct ttacctgaaa accagcccct tgaagggaca     1560

tttccctgtg actttgcttg gggagttgtt gacaactacg tacaagtaag tcctttgaca     1620

aaacccagtg tcggcctctt gcttcctcac                                      1650


<210>  85
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  85

Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu 
1               5                   10                  15      


Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala 
            20                  25                  30          


Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu 
        35                  40                  45              


Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr 
    50                  55                  60                  


Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro 
65                  70                  75                  80  


Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu 
                85                  90                  95      


Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His 
            100                 105                 110         


Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr 
        115                 120                 125             


Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His 
    130                 135                 140                 


Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile 
145                 150                 155                 160 


Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys 
                165                 170                 175     


Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu 
            180                 185                 190         


Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp 
        195                 200                 205             


Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp 
    210                 215                 220                 


Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His 
225                 230                 235                 240 


Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr 
                245                 250                 255     


Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn 
            260                 265                 270         


Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu 
        275                 280                 285             


Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser 
    290                 295                 300                 


Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val 
305                 310                 315                 320 


Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu 
                325                 330                 335     


Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg 
            340                 345                 350         


Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu 
        355                 360                 365             


Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly 
    370                 375                 380                 


Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr 
385                 390                 395                 400 


Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
                405                 410     


