                         SEQUENCE LISTING

<110>  UNIVERSITE PARIS DESCARTES
       
 
<120>  Method for the selection of serum biomarkers of epigenetic alterations,
       particularly of global hypomethylation and their uses 

<130>  362757 D30805

<150>  EP 12305449.6
<151>  2012-04-17

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Glu Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly 
            20                  25                  30          


Pro Arg Phe Gly Lys His Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys 
        35                  40                  45              


Thr Phe Thr Thr Thr Pro Gly Gly Trp Leu Leu Glu Ser Gly Arg Pro 
    50                  55                  60                  


Lys Glu Met Val Ser Thr Ser Asn Asn Lys Asp Gly Gln Ala Leu Gly 
65                  70                  75                  80  


Thr Thr Ser Glu Phe Ile Pro Asn Leu Ser Pro Glu Leu Lys Lys Pro 
                85                  90                  95      


Leu Ser Glu Gly Gln Pro Ser Leu Lys Lys Ile Ile Leu Ser Arg Lys 
            100                 105                 110         


Lys Arg Ser Gly Arg His Arg Phe Asp Pro Phe Cys Cys Glu Val Ile 
        115                 120                 125             


Cys Asp Asp Gly Thr Ser Val Lys Leu Cys Thr 
    130                 135                 


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Glu 
            20          


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly Pro Arg Phe Gly Lys His 
1               5                   10                  15      


Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys Thr Phe Thr Thr 
            20                  25                  30  


<210>  4
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Glu Ser Gly Arg Pro Lys Glu Met Val Ser Thr Ser Asn Asn Lys 
1               5                   10                  15      


Asp Gly Gln Ala Leu Gly Thr Thr Ser Glu Phe Ile Pro Asn Leu Ser 
            20                  25                  30          


Pro Glu Leu Lys Lys Pro Leu Ser Glu Gly Gln Pro Ser Leu Lys Lys 
        35                  40                  45              


Ile Ile 
    50  


<210>  5
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Gly Arg His Arg Phe Asp Pro Phe Cys Cys Glu Val Ile Cys Asp 
1               5                   10                  15      


Asp Gly Thr Ser Val Lys Leu Cys Thr 
            20                  25  


<210>  6
<211>  617
<212>  DNA
<213>  Homo sapiens

<400>  6
agtctggagc ccagaaggga cacaccagca cagtctggta ggctacagca gcaagtctct     60

aaagaaaggc tgagaacacc cagaacagga gagttcaggt ccaggatggc cagcctgttc    120

cggtcctatc tgccagcaat ctggctgctg ctgagccaac tccttagaga aagcctagca    180

gcagagctga ggggatgtgg tccccgattt ggaaaacact tgctgtcata ttgccccatg    240

cctgagaaga cattcaccac caccccagga gggtggctgc tggaatctgg acgtcccaaa    300

gaaatggtgt caacctccaa caacaaagat ggacaagcct taggtacgac atcagaattc    360

attcctaatt tgtcaccaga gctgaagaaa ccactgtctg aagggcagcc atcattgaag    420

aaaataatac tttcccgcaa aaagagaagt ggacgtcaca gatttgatcc attctgttgt    480

gaagtaattt gtgacgatgg aacttcagtt aaattatgta catagtagag taatcatgga    540

ctggacatct catccattct catatgtatt ctcaatgaca aattcactga tgcccaatta    600

aatgattgct gtttaaa                                                   617


<210>  7
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  7
atggccagcc tgttccggtc ctatctgcca gcaatctggc tgctgctgag ccaactcctt     60

agagaaagcc tagcagcaga gctgagggga tgtggtcccc gatttggaaa acacttgctg    120

tcatattgcc ccatgcctga gaagacattc accaccaccc caggagggtg gctgctggaa    180

tctggacgtc ccaaagaaat ggtgtcaacc tccaacaaca aagatggaca agccttaggt    240

acgacatcag aattcattcc taatttgtca ccagagctga agaaaccact gtctgaaggg    300

cagccatcat tgaagaaaat aatactttcc cgcaaaaaga gaagtggacg tcacagattt    360

gatccattct gttgtgaagt aatttgtgac gatggaactt cagttaaatt atgtaca       417


<210>  8
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  8
atggccagcc tgttccggtc ctatctgcca gcaatctggc tgctgctgag ccaactcctt     60

agagaa                                                                66


<210>  9
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  9
agcctagcag cagagctgag gggatgtggt ccccgatttg gaaaacactt gctgtcatat     60

tgccccatgc ctgagaagac attcaccacc                                      90


<210>  10
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  10
ctggaatctg gacgtcccaa agaaatggtg tcaacctcca acaacaaaga tggacaagcc     60

ttaggtacga catcagaatt cattcctaat ttgtcaccag agctgaagaa accactgtct    120

gaagggcagc catcattgaa gaaaataata                                     150


<210>  11
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  11
agtggacgtc acagatttga tccattctgt tgtgaagtaa tttgtgacga tggaacttca     60

gttaaattat gtaca 						      75

<210>  12
<211>  880
<212>  DNA
<213>  homo sapiens

<220>
<221>  misc_feature
<223>  Chorionic gonadotropin, beta polypeptide 5 (CGB5)

<400>  12
tccagcactt tgctcgggtc acggcctcct cctggctccc aggaccccac cataggcaga     60

ggcaggcctt cctacaccct actccctgtg cctccaggct cgactagtcc ctagcactcg    120

acgactgagt ctctgagatc acttcaccgt ggtctccgcc tcacccttgg cgctggacca    180

gtgagaggag agggctgggg cgctccgctg agccactcct gcgcccccct ggccttgtct    240

acctcttgcc ccccgaaggg ttagtgtcga gctcacccca gcatcctaca acctcctggt    300

ggccttgccg cccccacaac cccgaggtat aaagccaggt acacgaggca ggggacgcac    360

caaggatgga gatgttccag gggctgctgc tgttgctgct gctgagcatg ggcgggacat    420

gggcatccaa ggagccgctt cggccacggt gccgccccat caatgccacc ctggctgtgg    480

agaaggaggg ctgccccgtg tgcatcaccg tcaacaccac catctgtgcc ggctactgcc    540

ccaccatgac ccgcgtgctg cagggggtcc tgccggccct gcctcaggtg gtgtgcaact    600

accgcgatgt gcgcttcgag tccatccggc tccctggctg cccgcgcggc gtgaaccccg    660

tggtctccta cgccgtggct ctcagctgtc aatgtgcact ctgccgccgc agcaccactg    720

actgcggggg tcccaaggac caccccttga cctgtgatga cccccgcttc caggactcct    780

cttcctcaaa ggcccctccc cccagccttc caagtccatc ccgactcccg gggccctcgg    840

acaccccgat cctcccacaa taaaggcttc tcaatccgca                          880


<210>  13
<211>  165
<212>  PRT
<213>  homo sapiens

<220>
<221>  misc_feature
<223>  Chorionic gonadotropin, beta polypeptide 5 (CGB5)

<400>  13

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      

Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          

Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              

Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  

Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  

Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      

Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         

Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             

Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 

Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 

Pro Ile Leu Pro Gln 
                165 


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic 7-mer peptides corresponding to residues 1 through 7 of
       HCGbeta encoded by type II genes beta3, beta5 and beta8

<400>  14

Ser Lys Glu Pro Leu Arg Pro 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic 7-mer peptides corresponding to residues 1 through 7 of
       HCGbeta encoded by type I gene beta7

<400>  15

Ser Arg Glu Met Leu Arg Pro 
1               5           
                                                    


