﻿               SEQUENCE LISTING

<110> Universität Stuttgart

<120> The IgM and IgE heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity

<130> 762-2

<160> 27

<170> BiSSAP 1.0

<210> 1
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..111
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly 
1               5                   10                   15    
Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly 
            20                   25                  30        
Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln 
        35                   40                  45            
Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu 
    50                   55                  60                
Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu 
65                   70                  75                  80
Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His Arg 
                85                   90                  95    
Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                  105                110    

<210> 2
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..106
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly 
1               5                   10                   15    
Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            20                   25                  30        
Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        35                   40                  45            
Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu 
    50                   55                  60                
Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser 
65                   70                  75                  80
Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu 
                85                   90                  95    
Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
            100                  105    

<210> 3
<211> 265
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..265
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 3
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                   15    
Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                   25                  30        
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                   40                  45            
Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                   55                  60                
Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr 
65                   70                  75                  80
Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                   90                  95    
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                  105                110        
Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala 
        115                  120                125            
Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                  135                140                
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln 
145                  150                155                  160
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                  170                175    
Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
            180                  185                190        
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
        195                  200                205            
Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
    210                  215                220                
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                  230                235                  240
Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
                245                  250                255    
Gln Gly Thr Lys Val Glu Ile Lys Arg 
            260                  265

<210> 4
<211> 264
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..264
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                   15    
Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                   25                  30        
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                   40                  45            
Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly 
    50                   55                  60                
Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 
65                   70                  75                  80
Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                   90                  95    
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                  105                110        
Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 
        115                  120                125            
Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                  135                140                
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
145                  150                155                  160
Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                  170                175    
Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr 
            180                  185                190        
Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser 
        195                  200                205            
Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                  215                220                
Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                  230                235                  240
Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala 
                245                  250                255    
Gly Thr Lys Leu Glu Ile Lys Arg 
            260                

<210> 5
<211> 472
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..472
<223> /mol_type="protein"
      /note="scTNF"
      /organism="artificial sequences"

<400> 5
Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                   15    
Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
            20                   25                  30        
Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
        35                   40                  45            
Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    50                   55                  60                
Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
65                   70                  75                  80
Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
                85                   90                  95    
Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
            100                  105                110        
Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        115                  120                125            
Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
    130                  135                140                
Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser 
145                  150                155                  160
Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                165                  170                175    
Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            180                  185                190        
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        195                  200                205            
Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    210                  215                220                
Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
225                  230                235                  240
Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                245                  250                255    
Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            260                  265                270        
Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        275                  280                285            
Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    290                  295                300                
Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
305                  310                315                  320
Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                325                  330                335    
Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            340                  345                350        
Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        355                  360                365            
Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    370                  375                380                
Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
385                  390                395                  400
Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                405                  410                415    
Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            420                  425                430        
Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        435                  440                445            
Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
    450                  455                460                
Val Tyr Phe Gly Ile Ile Ala Leu 
465                  470        

<210> 6
<211> 580
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..580
<223> /mol_type="protein"
      /note="scTRAIL"
      /organism="artificial sequences"

<400> 6
Thr Arg Gly Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln 
1               5                   10                   15    
Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala 
            20                   25                  30        
Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
        35                   40                  45            
Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
    50                   55                  60                
Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
65                   70                  75                  80
Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
                85                   90                  95    
Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
            100                  105                110        
Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
        115                  120                125            
Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
    130                  135                140                
Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
145                  150                155                  160
Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
                165                  170                175    
Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly 
            180                  185                190        
Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln 
        195                  200                205            
Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln 
    210                  215                220                
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
225                  230                235                  240
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
                245                  250                255    
Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
            260                  265                270        
Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
        275                  280                285            
Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
    290                  295                300                
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
305                  310                315                  320
Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
                325                  330                335    
Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
            340                  345                350        
Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
        355                  360                365            
Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
    370                  375                380                
Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser 
385                  390                395                  400
Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
                405                  410                415    
Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
            420                  425                430        
Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
        435                  440                445            
Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
    450                  455                460                
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
465                  470                475                  480
Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
                485                  490                495    
Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
            500                  505                510        
Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
        515                  520                525            
Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
    530                  535                540                
Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
545                  550                555                  560
Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
                565                  570                575    
Phe Leu Val Gly 
            580

<210> 7
<211> 410
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..410
<223> /mol_type="protein"
      /note="scFvEGFR-MHD2"
      /organism="artificial sequences"

<400> 7
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu 
            20                   25                  30        
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                   40                  45            
Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
    50                   55                  60                
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
65                   70                  75                  80
Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 
                85                   90                  95    
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            100                  105                110        
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr 
        115                  120                125            
Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    130                  135                140                
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                  150                155                  160
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                  170                175    
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                  185                190        
Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                  200                205            
Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                  215                220                
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                  230                235                  240
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                  250                255    
Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
            260                  265                270        
Leu Gly Gly Ser Gly Gly Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
        275                  280                285            
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu 
    290                  295                300                
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp 
305                  310                315                  320
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val 
                325                  330                335    
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser 
            340                  345                350        
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr 
        355                  360                365            
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser 
    370                  375                380                
Met Cys Val Pro Asp Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Glu 
385                  390                395                  400
Phe Ala Ala Ala His His His His His His 
                405                  410

<210> 8
<211> 413
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..413
<223> /mol_type="protein"
      /note="MHD2-scFvHER2"
      /organism="Artificial Sequence"

<400> 8
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Ser Ala Gly Ala Gly Ser 
            20                   25                  30        
Leu Gly Gly Ser Gly Gly Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
        35                   40                  45            
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu 
    50                   55                  60                
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp 
65                   70                  75                  80
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val 
                85                   90                  95    
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser 
            100                  105                110        
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr 
        115                  120                125            
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser 
    130                  135                140                
Met Cys Val Pro Asp Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Gly 
145                  150                155                  160
Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                  170                175    
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
            180                  185                190        
Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                  200                205            
Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
    210                  215                220                
Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
225                  230                235                  240
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                245                  250                255    
Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
            260                  265                270        
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        275                  280                285            
Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr Gln Ser Pro 
    290                  295                300                
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
305                  310                315                  320
Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
                325                  330                335    
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
            340                  345                350        
Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
        355                  360                365            
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    370                  375                380                
Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
385                  390                395                  400
Glu Ile Lys Arg Ala Ala Ala His His His His His His 
                405                  410            

<210> 9
<211> 653
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..653
<223> /mol_type="protein"
      /note="scFvEGFR-MHD2-scFvHER2"
      /organism="artificial sequences"

<400> 9
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu 
            20                   25                  30        
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                   40                  45            
Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
    50                   55                  60                
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
65                   70                  75                  80
Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 
                85                   90                  95    
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            100                  105                110        
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr 
        115                  120                125            
Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    130                  135                140                
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                  150                155                  160
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                  170                175    
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                  185                190        
Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                  200                205            
Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                  215                220                
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                  230                235                  240
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                  250                255    
Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
            260                  265                270        
Leu Gly Gly Ser Gly Gly Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
        275                  280                285            
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu 
    290                  295                300                
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp 
305                  310                315                  320
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val 
                325                  330                335    
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser 
            340                  345                350        
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr 
        355                  360                365            
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser 
    370                  375                380                
Met Cys Val Pro Asp Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Gly 
385                  390                395                  400
Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                405                  410                415    
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
            420                  425                430        
Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        435                  440                445            
Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
    450                  455                460                
Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
465                  470                475                  480
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                485                  490                495    
Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
            500                  505                510        
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        515                  520                525            
Gly Gly Ser Gly Gly Gly Thr Gly Asp Ile Gln Met Thr Gln Ser Pro 
    530                  535                540                
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
545                  550                555                  560
Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
                565                  570                575    
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
            580                  585                590        
Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
        595                  600                605            
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    610                  615                620                
Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
625                  630                635                  640
Glu Ile Lys Arg Ala Ala Ala His His His His His His 
                645                  650            

<210> 10
<211> 648
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..648
<223> /mol_type="protein"
      /note="MHD2-scTNF"
      /organism="artificial sequences"

<400> 10
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Ser Ala Gly Ala Gly Ser 
            20                   25                  30        
Leu Gly Gly Ser Gly Gly Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
        35                   40                  45            
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu 
    50                   55                  60                
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp 
65                   70                  75                  80
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val 
                85                   90                  95    
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser 
            100                  105                110        
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr 
        115                  120                125            
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser 
    130                  135                140                
Met Cys Val Pro Asp Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Glu 
145                  150                155                  160
Phe Met Arg Gly Ser His His His His His His Gly Ser Ala Ser Ser 
                165                  170                175    
Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
            180                  185                190        
Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
        195                  200                205            
Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
    210                  215                220                
Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
225                  230                235                  240
Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
                245                  250                255    
Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
            260                  265                270        
Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
        275                  280                285            
Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    290                  295                300                
Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
305                  310                315                  320
Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser 
                325                  330                335    
Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
            340                  345                350        
Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
        355                  360                365            
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
    370                  375                380                
Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
385                  390                395                  400
Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
                405                  410                415    
Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
            420                  425                430        
Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
        435                  440                445            
Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
    450                  455                460                
Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
465                  470                475                  480
Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
                485                  490                495    
Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
            500                  505                510        
Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
        515                  520                525            
Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
    530                  535                540                
Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
545                  550                555                  560
Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
                565                  570                575    
Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
            580                  585                590        
Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
        595                  600                605            
Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
    610                  615                620                
Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
625                  630                635                  640
Val Tyr Phe Gly Ile Ile Ala Leu 
                645            

<210> 11
<211> 888
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..888
<223> /mol_type="protein"
      /note="scFvEGFR-MHD2-scTNF"
      /organism="artificial sequences"

<400> 11
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu 
            20                   25                  30        
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                   40                  45            
Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
    50                   55                  60                
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
65                   70                  75                  80
Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 
                85                   90                  95    
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            100                  105                110        
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr 
        115                  120                125            
Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    130                  135                140                
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                  150                155                  160
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                  170                175    
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                  185                190        
Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                  200                205            
Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                  215                220                
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                  230                235                  240
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                  250                255    
Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
            260                  265                270        
Leu Gly Gly Ser Gly Gly Ala Glu Leu Pro Pro Lys Val Ser Val Phe 
        275                  280                285            
Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu 
    290                  295                300                
Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp 
305                  310                315                  320
Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val 
                325                  330                335    
Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser 
            340                  345                350        
Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr 
        355                  360                365            
Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser 
    370                  375                380                
Met Cys Val Pro Asp Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Glu 
385                  390                395                  400
Phe Met Arg Gly Ser His His His His His His Gly Ser Ala Ser Ser 
                405                  410                415    
Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
            420                  425                430        
Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
        435                  440                445            
Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
    450                  455                460                
Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
465                  470                475                  480
Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
                485                  490                495    
Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
            500                  505                510        
Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
        515                  520                525            
Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
    530                  535                540                
Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
545                  550                555                  560
Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser 
                565                  570                575    
Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
            580                  585                590        
Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
        595                  600                605            
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
    610                  615                620                
Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
625                  630                635                  640
Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
                645                  650                655    
Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
            660                  665                670        
Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
        675                  680                685            
Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
    690                  695                700                
Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
705                  710                715                  720
Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
                725                  730                735    
Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
            740                  745                750        
Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
        755                  760                765            
Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
    770                  775                780                
Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
785                  790                795                  800
Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
                805                  810                815    
Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
            820                  825                830        
Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
        835                  840                845            
Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
    850                  855                860                
Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
865                  870                875                  880
Val Tyr Phe Gly Ile Ile Ala Leu 
                885            

<210> 12
<211> 724
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..724
<223> /mol_type="protein"
      /note="MHD2-scTRAIL"
      /organism="artificial sequences"

<400> 12
Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                   15    
Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Ala 
            20                   25                  30        
Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe 
        35                   40                  45            
Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe 
    50                   55                  60                
Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val 
65                   70                  75                  80
Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser 
                85                   90                  95    
Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser 
            100                  105                110        
Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His Arg Gly 
        115                  120                125            
Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp Glu Phe 
    130                  135                140                
Thr Arg Gly Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln 
145                  150                155                  160
Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala 
                165                  170                175    
Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
            180                  185                190        
Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
        195                  200                205            
Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
    210                  215                220                
Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
225                  230                235                  240
Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
                245                  250                255    
Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
            260                  265                270        
Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
        275                  280                285            
Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
    290                  295                300                
Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
305                  310                315                  320
Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly 
                325                  330                335    
Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln 
            340                  345                350        
Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln 
        355                  360                365            
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
    370                  375                380                
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
385                  390                395                  400
Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
                405                  410                415    
Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
            420                  425                430        
Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
        435                  440                445            
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
    450                  455                460                
Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
465                  470                475                  480
Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
                485                  490                495    
Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
            500                  505                510        
Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
        515                  520                525            
Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser 
    530                  535                540                
Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
545                  550                555                  560
Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
                565                  570                575    
Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
            580                  585                590        
Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
        595                  600                605            
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
    610                  615                620                
Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
625                  630                635                  640
Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
                645                  650                655    
Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
            660                  665                670        
Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
        675                  680                685            
Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
    690                  695                700                
Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
705                  710                715                  720
Phe Leu Val Gly 
                

<210> 13
<211> 958
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..958
<223> /mol_type="protein"
      /note="scFvEGFR-MHD2-scTRAIL"
      /organism="artificial sequences"

<400> 13
Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Ala Ala Gln 
1               5                   10                   15    
Pro Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                   25                  30        
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
        35                   40                  45            
Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                   55                  60                
Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 
65                   70                  75                  80
Thr Pro Phe Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                   90                  95    
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                  105                110        
Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
        115                  120                125            
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                  135                140                
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln 
145                  150                155                  160
Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                  170                175    
Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln 
            180                  185                190        
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser 
        195                  200                205            
Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
    210                  215                220                
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
225                  230                235                  240
Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr 
                245                  250                255    
Lys Leu Glu Ile Lys Arg Ala Ala Ala Ala Glu Leu Pro Pro Lys Val 
            260                  265                270        
Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys 
        275                  280                285            
Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln 
    290                  295                300                
Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr 
305                  310                315                  320
Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys 
                325                  330                335    
Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln Ser 
            340                  345                350        
Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn 
        355                  360                365            
Ala Ser Ser Met Cys Val Pro Asp Glu Phe Thr Arg Gly Thr Ser Glu 
    370                  375                380                
Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu 
385                  390                395                  400
Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
                405                  410                415    
Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            420                  425                430        
Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        435                  440                445            
Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    450                  455                460                
Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
465                  470                475                  480
Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                485                  490                495    
Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            500                  505                510        
Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        515                  520                525            
Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    530                  535                540                
Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
545                  550                555                  560
Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                565                  570                575    
Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
            580                  585                590        
Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
        595                  600                605            
Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    610                  615                620                
Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
625                  630                635                  640
Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                645                  650                655    
Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            660                  665                670        
Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        675                  680                685            
Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    690                  695                700                
Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
705                  710                715                  720
Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                725                  730                735    
Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            740                  745                750        
Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly 
        755                  760                765            
Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln 
    770                  775                780                
Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala 
785                  790                795                  800
Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
                805                  810                815    
Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
            820                  825                830        
Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
        835                  840                845            
Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
    850                  855                860                
Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
865                  870                875                  880
Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
                885                  890                895    
Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
            900                  905                910        
Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
        915                  920                925            
Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
    930                  935                940                
Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
945                  950                955            

<210> 14
<211> 1217
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..1217
<223> /mol_type="protein"
      /note="scDbEpCAMxEGFR-MHD2-scTRAIL"
      /organism="artificial sequences"

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                   25                  30        
Ser Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Gln Ser Gly 
        35                   40                  45            
Pro Gly Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala 
    50                   55                  60                
Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala 
65                   70                  75                  80
Pro Gly Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly 
                85                   90                  95    
Glu Ser Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu 
            100                  105                110        
Asp Thr Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala 
        115                  120                125            
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp 
    130                  135                140                
Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Gly Gly Gly Gly 
145                  150                155                  160
Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val 
                165                  170                175    
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr 
            180                  185                190        
Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                  200                205            
Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser 
    210                  215                220                
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                  230                235                  240
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro 
                245                  250                255    
Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
            260                  265                270        
Gly Ser Gly Gly Arg Ala Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        275                  280                285            
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    290                  295                300                
Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
305                  310                315                  320
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                325                  330                335    
Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 
            340                  345                350        
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                  360                365            
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr 
    370                  375                380                
Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
385                  390                395                  400
Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
                405                  410                415    
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            420                  425                430        
Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp 
        435                  440                445            
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gln Met 
    450                  455                460                
Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Ser Ser Gly Ser 
465                  470                475                  480
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                485                  490                495    
Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly 
            500                  505                510        
Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Ala Ala Ala Glu Leu Pro 
        515                  520                525            
Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn 
    530                  535                540                
Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg 
545                  550                555                  560
Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly 
                565                  570                575    
Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr 
            580                  585                590        
Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu 
        595                  600                605            
Gly Gln Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe 
    610                  615                620                
Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp Glu Phe Thr Arg Gly 
625                  630                635                  640
Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
                645                  650                655    
Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            660                  665                670        
Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        675                  680                685            
Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    690                  695                700                
Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
705                  710                715                  720
Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                725                  730                735    
Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            740                  745                750        
Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        755                  760                765            
Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    770                  775                780                
Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
785                  790                795                  800
Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                805                  810                815    
Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly 
            820                  825                830        
Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln 
        835                  840                845            
Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala 
    850                  855                860                
Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
865                  870                875                  880
Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
                885                  890                895    
Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
            900                  905                910        
Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
        915                  920                925            
Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
    930                  935                940                
Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
945                  950                955                  960
Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
                965                  970                975    
Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
            980                  985                990        
Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
        995                  1000                1005            
Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly 
    1010                1015                1020                
Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser Thr Val Gln 
1025                1030                1035                1040
Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln 
                1045                1050                1055    
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
            1060                1065                1070        
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
        1075                1080                1085            
Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
    1090                1095                1100                
Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
1105                1110                1115                1120
Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
                1125                1130                1135    
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
            1140                1145                1150        
Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
        1155                1160                1165            
Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
    1170                1175                1180                
Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
1185                1190                1195                1200
Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
                1205                1210                1215    
Gly 
    

<210> 15
<211> 405
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..405
<223> /mol_type="protein"
      /note="scFvEGFR-EHD2"
      /organism="artificial sequences"

<400> 15
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu 
            20                   25                  30        
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                   40                  45            
Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 
    50                   55                  60                
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
65                   70                  75                  80
Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 
                85                   90                  95    
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
            100                  105                110        
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr 
        115                  120                125            
Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
    130                  135                140                
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                  150                155                  160
Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                  170                175    
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                  185                190        
Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                  200                205            
Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                  215                220                
Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                  230                235                  240
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                  250                255    
Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
            260                  265                270        
Leu Gly Gly Ser Gly Gly Asp Phe Thr Pro Pro Thr Val Lys Ile Leu 
        275                  280                285            
Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu 
    290                  295                300                
Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp 
305                  310                315                  320
Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr 
                325                  330                335    
Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser 
            340                  345                350        
Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr 
        355                  360                365            
Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
    370                  375                380                
Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Glu Phe Ala Ala Ala His 
385                  390                395                  400
His His His His His 
                405

<210> 16
<211> 731
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..731
<223> /mol_type="protein"
      /note="EHD2-scTRAIL"
      /organism="artificial sequences"

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                   25                  30        
Ser Ala Ala Gln Pro Ala Asp Phe Thr Pro Pro Thr Val Lys Ile Leu 
        35                   40                  45            
Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu 
    50                   55                  60                
Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp 
65                   70                  75                  80
Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr 
                85                   90                  95    
Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser 
            100                  105                110        
Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr 
        115                  120                125            
Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
    130                  135                140                
Gly Gly Ser Gly Gly Glu Phe Thr Arg Gly Thr Ser Glu Glu Thr Ile 
145                  150                155                  160
Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu 
                165                  170                175    
Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
            180                  185                190        
Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
        195                  200                205            
Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
    210                  215                220                
Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
225                  230                235                  240
Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
                245                  250                255    
Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
            260                  265                270        
Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
        275                  280                285            
Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
    290                  295                300                
Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
305                  310                315                  320
Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
                325                  330                335    
Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Ser Glu 
            340                  345                350        
Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu 
        355                  360                365            
Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
    370                  375                380                
Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
385                  390                395                  400
Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
                405                  410                415    
Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
            420                  425                430        
Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
        435                  440                445            
Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
    450                  455                460                
Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
465                  470                475                  480
Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
                485                  490                495    
Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
            500                  505                510        
Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
        515                  520                525            
Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser 
    530                  535                540                
Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
545                  550                555                  560
Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
                565                  570                575    
Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
            580                  585                590        
Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
        595                  600                605            
Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
    610                  615                620                
Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
625                  630                635                  640
Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
                645                  650                655    
Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
            660                  665                670        
Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
        675                  680                685            
Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
    690                  695                700                
Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
705                  710                715                  720
Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                725                  730    

<210> 17
<211> 983
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..983
<223> /mol_type="protein"
      /note="scFvEGFR-EHD2-scTRAIL"
      /organism="artificial sequences"

<400> 17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                   15    
Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                   25                  30        
Ser Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Ser Gly 
        35                   40                  45            
Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    50                   55                  60                
Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ala 
65                   70                  75                  80
Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn 
                85                   90                  95    
Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Ser Arg Asp 
            100                  105                110        
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        115                  120                125            
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr 
    130                  135                140                
Glu Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
145                  150                155                  160
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                165                  170                175    
Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg 
            180                  185                190        
Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
        195                  200                205            
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr 
    210                  215                220                
Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
225                  230                235                  240
Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                245                  250                255    
Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe 
            260                  265                270        
Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Gly Ser 
        275                  280                285            
Gly Gly Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys 
    290                  295                300                
Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val 
305                  310                315                  320
Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly 
                325                  330                335    
Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly 
            340                  345                350        
Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp 
        355                  360                365            
Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr 
    370                  375                380                
Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Gly Gly Ser Gly 
385                  390                395                  400
Gly Glu Phe Thr Arg Gly Thr Ser Glu Glu Thr Ile Ser Thr Val Gln 
                405                  410                415    
Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly Pro Gln 
            420                  425                430        
Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        435                  440                445            
Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    450                  455                460                
Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
465                  470                475                  480
Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                485                  490                495    
Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            500                  505                510        
Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        515                  520                525            
Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    530                  535                540                
Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
545                  550                555                  560
Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                565                  570                575    
Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            580                  585                590        
Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu Thr Ile Ser 
        595                  600                605            
Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg 
    610                  615                620                
Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
625                  630                635                  640
Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
                645                  650                655    
Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
            660                  665                670        
Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
        675                  680                685            
Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
    690                  695                700                
Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
705                  710                715                  720
Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
                725                  730                735    
Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
            740                  745                750        
Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
        755                  760                765            
Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
    770                  775                780                
Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser Thr Ser Glu Glu 
785                  790                795                  800
Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val 
                805                  810                815    
Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
            820                  825                830        
Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        835                  840                845            
Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    850                  855                860                
Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
865                  870                875                  880
Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                885                  890                895    
Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            900                  905                910        
Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        915                  920                925            
Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    930                  935                940                
Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
945                  950                955                  960
Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                965                  970                975    
Phe Gly Ala Phe Leu Val Gly 
            980            

<210> 18
<211> 5
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /note="peptide linker 1"
      /organism="artificial sequences"

<400> 18
Gly Gly Gly Gly Ser 
1               5

<210> 19
<211> 10
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /note="peptide linker 2"
      /organism="artificial sequences"

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10

<210> 20
<211> 15
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..15
<223> /mol_type="protein"
      /note="peptide linker 1"
      /organism="artificial sequences"

<400> 20
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                   15

<210> 21
<211> 8
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..8
<223> /mol_type="protein"
      /note="peptide linker 3"
      /organism="artificial sequences"

<400> 21
Gly Ser Leu Gly Gly Ser Gly Gly 
1               5            

<210> 22
<211> 8
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..8
<223> /mol_type="protein"
      /note="peptide linker 4"
      /organism="artificial sequences"

<400> 22
Gly Gly Gly Ser Gly Gly Gly Thr 
1               5            

<210> 23
<211> 10
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..10
<223> /mol_type="protein"
      /note="peptide linker 5"
      /organism="artificial sequences"

<400> 23
Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser 
1               5                   10

<210> 24
<211> 12
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..12
<223> /mol_type="protein"
      /note="peptide linker 6"
      /organism="artificial sequences"

<400> 24
Gly Gly Gly Ser Gly Gly Gly Thr Gly Ser Gly Gly 
1               5                   10        

<210> 25
<211> 8
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..8
<223> /mol_type="protein"
      /note="peptide linker 7"
      /organism="artificial sequences"

<400> 25
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5            

<210> 26
<211> 5
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..5
<223> /mol_type="protein"
      /note="peptide linker 8"
      /organism="artificial sequences"

<400> 26
Glu Phe Thr Arg Gly 
1               5

<210> 27
<211> 4
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..4
<223> /mol_type="protein"
      /note="peptide linker 89"
      /organism="artificial sequences"

<400> 27
Ala Ala Ala Ala 
1               

