                         SEQUENCE LISTING

<110>  Integrative Enzymatics Inc.
       Gavini, Madhavi
       Srinivas, Raja
 
<120>  Composition and Method for Modulating Inflammatory Molecules with
        Amylase

<130>  33400-1001

<150>  61//623,485
<151>  2012-04-12

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  homo sapien

<400>  1

Gln Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  2
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  3
<211>  511
<212>  PRT
<213>  homo sapien

<400>  3

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Arg Tyr Phe Glu 
    290                 295                 300                 


Asn Gly Lys Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly 
305                 310                 315                 320 


Val Thr Lys Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp 
                325                 330                 335     


Trp Val Cys Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe 
            340                 345                 350         


Arg Asn Val Val Asp Gly Gln Pro Phe Met Pro Ser Asp Arg Ala Leu 
        355                 360                 365             


Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His Gly Ala Gly Gly 
    370                 375                 380                 


Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr Lys Met Ala Val 
385                 390                 395                 400 


Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg Val Met Ser Ser 
                405                 410                 415     


Tyr Arg Trp Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  4
<211>  511
<212>  PRT
<213>  homo sapien

<400>  4

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  5
<211>  511
<212>  PRT
<213>  homo sapien

<400>  5

Met Lys Leu Phe Trp Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Gln 
1               5                   10                  15      


Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu Phe 
            20                  25                  30          


Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu Ala 
        35                  40                  45              


Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn Val 
    50                  55                  60                  


Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro Val 
65                  70                  75                  80  


Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg Asn 
                85                  90                  95      


Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp Ala 
            100                 105                 110         


Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser Ser 
        115                 120                 125             


Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala Val 
    130                 135                 140                 


Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly Ser 
145                 150                 155                 160 


Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys Arg 
                165                 170                 175     


Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg Ser 
            180                 185                 190         


Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala Gly 
        195                 200                 205             


Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys Ala 
    210                 215                 220                 


Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu Gly 
225                 230                 235                 240 


Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu Pro 
                245                 250                 255     


Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe Lys 
            260                 265                 270         


Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu Lys 
        275                 280                 285             


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro Ser 
    290                 295                 300                 


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
305                 310                 315                 320 


Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr 
                325                 330                 335     


Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg 
            340                 345                 350         


Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys Asp 
        355                 360                 365             


Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys Glu 
    370                 375                 380                 


Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu 
385                 390                 395                 400 


His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val Val 
                405                 410                 415     


Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val 
            420                 425                 430         


Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp 
        435                 440                 445             


Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr 
    450                 455                 460                 


Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile 
465                 470                 475                 480 


Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn 
                485                 490                 495     


Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
            500                 505                 510     


<210>  6
<211>  254
<212>  PRT
<213>  homo sapien

<400>  6

Met Lys Phe Phe Leu Leu Leu Phe Thr Ile Gly Phe Cys Trp Ala Phe 
1               5                   10                  15      


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Glu Lys 
            20                  25                  30          


Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro Ser 
        35                  40                  45              


Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His 
    50                  55                  60                  


Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr Lys 
65                  70                  75                  80  


Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg Val 
                85                  90                  95      


Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn Asp Val 
            100                 105                 110         


Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys Glu Val 
        115                 120                 125             


Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys Glu His 
    130                 135                 140                 


Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val Val Asp 
145                 150                 155                 160 


Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln Val Ala 
                165                 170                 175     


Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp Asp Trp 
            180                 185                 190         


Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr Tyr Cys 
        195                 200                 205             


Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly Ile Lys 
    210                 215                 220                 


Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser Asn Ser 
225                 230                 235                 240 


Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                245                 250                 


<210>  7
<211>  496
<212>  PRT
<213>  homo sapien

<400>  7

Gln Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Arg Tyr Phe 
        275                 280                 285             


Glu Asn Gly Lys Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn 
    290                 295                 300                 


Gly Val Thr Lys Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn 
305                 310                 315                 320 


Asp Trp Val Cys Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn 
                325                 330                 335     


Phe Arg Asn Val Val Asp Gly Gln Pro Phe Met Pro Ser Asp Arg Ala 
            340                 345                 350         


Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly His Gly Ala Gly 
        355                 360                 365             


Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu Tyr Lys Met Ala 
    370                 375                 380                 


Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr Arg Val Met Ser 
385                 390                 395                 400 


Ser Tyr Arg Trp Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  8
<211>  496
<212>  PRT
<213>  homo sapien

<400>  8

Gln Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  9
<211>  496
<212>  PRT
<213>  homo sapien

<400>  9

Gln Tyr Ser Ser Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Ser Gly Leu Leu Asp Leu Ala Leu Gly Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Ile Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Glu 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Tyr Phe Glu Asn Gly Lys 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asp Asn Gly Val Thr Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  10
<211>  496
<212>  PRT
<213>  homo sapien

<400>  10

Gln Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile Tyr Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Cys Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Thr Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Val Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Ile Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Ser Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


<210>  11
<211>  496
<212>  PRT
<213>  homo sapien

<400>  11

Gln Tyr Ser Pro Asn Thr Gln Gln Gly Arg Thr Ser Ile Val His Leu 
1               5                   10                  15      


Phe Glu Trp Arg Trp Val Asp Ile Ala Leu Glu Cys Glu Arg Tyr Leu 
            20                  25                  30          


Ala Pro Lys Gly Phe Gly Gly Val Gln Val Ser Pro Pro Asn Glu Asn 
        35                  40                  45              


Val Ala Ile His Asn Pro Phe Arg Pro Trp Trp Glu Arg Tyr Gln Pro 
    50                  55                  60                  


Val Ser Tyr Lys Leu Cys Thr Arg Ser Gly Asn Glu Asp Glu Phe Arg 
65                  70                  75                  80  


Asn Met Val Thr Arg Cys Asn Asn Val Gly Val Arg Ile Tyr Val Asp 
                85                  90                  95      


Ala Val Ile Asn His Met Ser Gly Asn Ala Val Ser Ala Gly Thr Ser 
            100                 105                 110         


Ser Thr Cys Gly Ser Tyr Phe Asn Pro Gly Ser Arg Asp Phe Pro Ala 
        115                 120                 125             


Val Pro Tyr Ser Gly Trp Asp Phe Asn Asp Gly Lys Cys Lys Thr Gly 
    130                 135                 140                 


Ser Gly Asp Ile Glu Asn Tyr Asn Asp Ala Thr Gln Val Arg Asp Cys 
145                 150                 155                 160 


Arg Leu Val Gly Leu Leu Asp Leu Ala Leu Glu Lys Asp Tyr Val Arg 
                165                 170                 175     


Ser Lys Ile Ala Glu Tyr Met Asn His Leu Ile Asp Ile Gly Val Ala 
            180                 185                 190         


Gly Phe Arg Leu Asp Ala Ser Lys His Met Trp Pro Gly Asp Ile Lys 
        195                 200                 205             


Ala Ile Leu Asp Lys Leu His Asn Leu Asn Ser Asn Trp Phe Pro Ala 
    210                 215                 220                 


Gly Ser Lys Pro Phe Ile Tyr Gln Glu Val Ile Asp Leu Gly Gly Glu 
225                 230                 235                 240 


Pro Ile Lys Ser Ser Asp Tyr Phe Gly Asn Gly Arg Val Thr Glu Phe 
                245                 250                 255     


Lys Tyr Gly Ala Lys Leu Gly Thr Val Ile Arg Lys Trp Asn Gly Glu 
            260                 265                 270         


Lys Met Ser Tyr Leu Lys Asn Trp Gly Glu Gly Trp Gly Phe Met Pro 
        275                 280                 285             


Ser Asp Arg Ala Leu Val Phe Val Asp Asn His Asp Asn Gln Arg Gly 
    290                 295                 300                 


His Gly Ala Gly Gly Ala Ser Ile Leu Thr Phe Trp Asp Ala Arg Leu 
305                 310                 315                 320 


Tyr Lys Met Ala Val Gly Phe Met Leu Ala His Pro Tyr Gly Phe Thr 
                325                 330                 335     


Arg Val Met Ser Ser Tyr Arg Trp Pro Arg Gln Phe Gln Asn Gly Asn 
            340                 345                 350         


Asp Val Asn Asp Trp Val Gly Pro Pro Asn Asn Asn Gly Val Ile Lys 
        355                 360                 365             


Glu Val Thr Ile Asn Pro Asp Thr Thr Cys Gly Asn Asp Trp Val Cys 
    370                 375                 380                 


Glu His Arg Trp Arg Gln Ile Arg Asn Met Val Asn Phe Arg Asn Val 
385                 390                 395                 400 


Val Asp Gly Gln Pro Phe Thr Asn Trp Tyr Asp Asn Gly Ser Asn Gln 
                405                 410                 415     


Val Ala Phe Gly Arg Gly Asn Arg Gly Phe Ile Val Phe Asn Asn Asp 
            420                 425                 430         


Asp Trp Thr Phe Ser Leu Thr Leu Gln Thr Gly Leu Pro Ala Gly Thr 
        435                 440                 445             


Tyr Cys Asp Val Ile Ser Gly Asp Lys Ile Asn Gly Asn Cys Thr Gly 
    450                 455                 460                 


Ile Lys Ile Tyr Val Ser Asp Asp Gly Lys Ala His Phe Ser Ile Ser 
465                 470                 475                 480 


Asn Ser Ala Glu Asp Pro Phe Ile Ala Ile His Ala Glu Ser Lys Leu 
                485                 490                 495     


