                         SEQUENCE LISTING

<110>  University of Southern California
       Rodgers, Kathleen E.
       DiZerega, Gere S.
       Louir, Stan
       Mordwinkin, Nick
 
<120>  12-386-PCT

<130>  Mol markers of endothelial dysfunction in gestational diabetes

<150>  61/621762
<151>  2012-04-09

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is H, D, E, N, Acpc, A, Me2Gly, P, Bet, Glu(NH2), G, Asp(NH2) 
       and Suc, or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Arg, Lys, Ala, Cit, Orn, Ser(Ac), Sar, D-Arg or D-Lys

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Val, Ala, Leu, norLeu, Ile, Gly, Lys, Pro, Aib, Acpc or Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Tyr, Tyr(PO3)2, Thr, Ser, homoSer, azaTyr, or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Ile, Ala, Leu, norLeu, Val or Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is His, Arg or 6-NH2-Phe

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Phe, Phe(Br), Ile or Tyr, excluding sequences including R4 
       as a terminal Tyr group

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Arg Val Tyr Ile His Pro Phe 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Val Tyr Ile His Pro Phe 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Arg Val Tyr Ile His Pro 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Arg Val Tyr Ile His Pro 
1               5       


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Val Tyr Ile His Pro 
1               5   


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ile His Pro Phe 
1               


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Asp Arg Val Tyr Ile His 
1               5       


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Asp Arg Val Tyr Ile 
1               5   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Asp Arg Val Tyr 
1               


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Nle

<400>  11

Arg Xaa Tyr Ile His Pro Phe 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Nle

<400>  12

Arg Val Tyr Xaa His Pro Phe 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Asp Arg Pro Tyr Ile His Pro Phe 
1               5               


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is H, Arg, Lys, Ala, Orn, Citron, Ser(Ac), Sar, D-Arg or D-Lys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Val, Ala, Leu, norLeu, Ile, Gly, Lys, Pro, Aib, Acpc or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Tyr, Tyr(PO3)2, Thr, Ser, homoSer, azaTyr, or Ala

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Ile, Ala, Leu, norLeu, Val or Gly

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is His, Arg or 6-NH2-Phe

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Phe, Phe(Br), Ile or Tyr, excluding sequences including R4 
       as a terminal Tyr group

<400>  14

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  15
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Ser Val Thr Val Thr Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg 
1               5                   10                  15      


Ala Arg Ser Thr Gln Gly Glu Val Thr Arg Glu Pro Pro Gly Met Arg 
            20                  25                  30          


Leu Ser Ser Ser Leu Trp 
        35              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Asp and Glu, or is absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Arg, Lys, or Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Val, Ala, Leu, norLeu, Ile, Gly, Lys, or Pro

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Tyr or  homoSer

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Ile, Ala, Leu, norLeu, Val or Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is His or Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Phe, Ile or is absent

<400>  16

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Asp Arg Val Tyr Val His Pro Phe 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Asn Arg Val Tyr Val His Pro Phe 
1               5               


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ala Pro Gly Asp Arg Ile Tyr Val His Pro Phe 
1               5                   10      


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Glu Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asp Lys Val Tyr Ile His Pro Phe 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Asp Arg Ala Tyr Ile His Pro Phe 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Asp Arg Val Thr Ile His Pro Phe 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Asp Arg Val Tyr Leu His Pro Phe 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Asp Arg Val Tyr Ile Arg Pro Phe 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Asp Arg Val Tyr Ile His Ala Phe 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Asp Arg Val Tyr Ile His Pro Tyr 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Pro Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Tyr(PO3)2

<400>  29

Asp Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Nle

<400>  30

Asp Arg Xaa Tyr Ile His Pro Phe 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Nle

<400>  31

Asp Arg Val Tyr Xaa His Pro Phe 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  homoSer

<400>  32

Asp Arg Val Xaa Tyr Ile His Pro Phe 
1               5                   


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Nle

<400>  33

Asp Arg Xaa Tyr Ile His Pro 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is H, Arg, Lys, Ala, Orn, Citron, Ser(Ac), Sar, D-Arg or D-Lys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Val, Ala, Leu, norLeu, Ile, Gly, Lys, Pro, Aib, Acpc or Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Ile, Ala, Leu, norLeu, Val or Gly

<400>  34

Xaa Xaa Tyr Xaa His Pro Phe 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Arg Val Tyr Gly His Pro Phe 
1               5           


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Val Tyr Ala His Pro Phe 
1               5       


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Asp Arg Val Ala Ile His Pro 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Asp Arg Pro Tyr Ile His Pro 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Asp Arg Lys Tyr Ile His Pro 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Nle

<400>  40

Asp Arg Xaa Tyr Ile His Pro 
1               5           


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Asp Arg Val Tyr Ile His Pro Ile 
1               5               


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Arg Val Ala Ile His Pro Phe 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Arg Val Ala Ile His Pro Phe 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gly Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Nle

<400>  45

Arg Val Tyr Xaa His Pro Phe 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is -aminocyclopentane carboxylic acid (Acpc) a modified amino 
       acid

<400>  46

Asp Arg Xaa Tyr Ile His Pro Phe 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Orn

<400>  47

Asp Xaa Val Tyr Ile His Pro Phe 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Citron-a modified amino acid

<400>  48

Asp Xaa Val Tyr Ile His Pro Phe 
1               5               


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Asp Arg Pro Ala Ile His Pro 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3Hyp

<400>  50

Asp Arg Pro Ala Ile His Pro 
1               5           


<210>  51
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  51

Phe Lys Ile Glu Thr Thr Pro Glu Ser Arg Tyr Leu Ala Gln Ile Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Thr Cys Ser Thr Thr Gly Cys Glu Ser Pro Phe 
            20                  25                  30          


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Asn Gly Lys Val Thr 
        35                  40                  45              


Asn Glu Gly Thr Thr Ser Thr Leu Thr Met Asn Pro Val Ser Phe Gly 
    50                  55                  60                  


Asn Glu His Ser Tyr Leu Cys Thr Ala Thr Cys Glu Ser Arg Lys Leu 
65                  70                  75                  80  


Glu Lys Gly Ile Gln Val Glu Ile Tyr Ser Phe Pro Lys Asp Pro Glu 
                85                  90                  95      


Ile His Leu Ser Gly Pro Leu Glu Ala Gly Lys Pro Ile Thr Val Lys 
            100                 105                 110         


Cys Ser Val Ala Asp Val Tyr Pro Phe Asp Arg Leu Glu Ile Asp Leu 
        115                 120                 125             


Leu Lys Gly Asp His Leu Met Lys Ser Gln Glu Phe Leu Glu Asp Ala 
    130                 135                 140                 


Asp Arg Lys Ser Leu Glu Thr Lys Ser Leu Glu Val Thr Phe Thr Pro 
145                 150                 155                 160 


Val Ile Glu Asp Ile Gly Lys Val Leu Val Cys Arg Ala Lys Leu His 
                165                 170                 175     


Ile Asp Glu Met Asp Ser Val Pro Thr Val Arg Gln Ala Val Lys Glu 
            180                 185                 190         


Leu Gln Val Tyr Ile Ser Pro Lys Asn Thr Val Ile Ser Val Asn Pro 
        195                 200                 205             


Ser Thr Lys Leu Gln Glu Gly Gly Ser Val Thr Met Thr Cys Ser Ser 
    210                 215                 220                 


Glu Gly Leu Pro Ala Pro Glu Ile Phe Trp Ser Lys Lys Leu Asp Asn 
225                 230                 235                 240 


Gly Asn Leu Gln His Leu Ser Gly Asn Ala Thr Leu Thr Leu Ile Ala 
                245                 250                 255     


Met Arg Met Glu Asp Ser Gly Ile Tyr Val Cys Glu Gly Val Asn Leu 
            260                 265                 270         


Ile Gly Lys Asn Arg Lys Glu Val Glu Leu Ile Val Gln Glu Lys Pro 
        275                 280                 285             


Phe Thr Val Glu Ile Ser Pro Gly Pro Arg Ile Ala Ala Gln Ile Gly 
    290                 295                 300                 


Asp Ser Val Met Leu Thr Cys Ser Val Met Gly Cys Glu Ser Pro Ser 
305                 310                 315                 320 


Phe Ser Trp Arg Thr Gln Ile Asp Ser Pro Leu Ser Gly Lys Val Arg 
                325                 330                 335     


Ser Glu Gly Thr Asn Ser Thr Leu Thr Leu Ser Pro Val Ser Phe Glu 
            340                 345                 350         


Asn Glu His Ser Tyr Leu Cys Thr Val Thr Cys Gly His Lys Lys Leu 
        355                 360                 365             


Glu Lys Gly Ile Gln Val Glu Leu Tyr Ser Phe Pro Arg Asp Pro Glu 
    370                 375                 380                 


Ile Glu Met Ser Gly Gly Leu Val Asn Gly Ser Ser Val Thr Val Ser 
385                 390                 395                 400 


Cys Lys Val Pro Ser Val Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu 
                405                 410                 415     


Leu Lys Gly Glu Thr Ile Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr 
            420                 425                 430         


Asp Met Lys Ser Leu Glu Asn Lys Ser Leu Glu Met Thr Phe Ile Pro 
        435                 440                 445             


Thr Ile Glu Asp Thr Gly Lys Ala Leu Val Cys Gln Ala Lys Leu His 
    450                 455                 460                 


Ile Asp Asp Met Glu Phe Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr 
465                 470                 475                 480 


Leu Tyr Val Asn Val Ala Pro Arg Asp Thr Thr Val Leu Val Ser Pro 
                485                 490                 495     


Ser Ser Ile Leu Glu Glu Gly Ser Ser Val Asn Met Thr Cys Leu Ser 
            500                 505                 510         


Gln Gly Phe Pro Ala Pro Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn 
        515                 520                 525             


Gly Glu Leu Gln Pro Leu Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser 
    530                 535                 540                 


Thr Lys Met Glu Asp Ser Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln 
545                 550                 555                 560 


Ala Gly Arg Ser Arg Lys Glu Val Glu Leu Ile Ile Gln Val Thr Pro 
                565                 570                 575     


Lys Asp Ile Lys Leu Thr Ala Phe Pro Ser Glu Ser Val Lys Glu Gly 
            580                 585                 590         


Asp Thr Val Ile Ile Ser Cys Thr Cys Gly Asn Val Pro Glu Thr Trp 
        595                 600                 605             


Ile Ile Leu Lys Lys Lys Ala Glu Thr Gly Asp Thr Val Leu Lys Ser 
    610                 615                 620                 


Ile Asp Gly Ala Tyr Thr Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly 
625                 630                 635                 640 


Val Tyr Glu Cys Glu Ser Lys Asn Lys Val Gly Ser Gln Leu Arg Ser 
                645                 650                 655     


Leu Thr Leu Asp Val Gln Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser 
            660                 665                 670         


Pro 
    


<210>  52
<211>  4337
<212>  DNA
<213>  Homo sapiens

<400>  52
actgaaacta ggggcaagga gacgaagaga acatgaaagt taaactttaa gatgaagaac       60

aaagctgaac atactgatgc attggatctt tggagaggat ctcagaactc attgtactta      120

atttacaggc taaaacctta gaagaggaat ttattatatc ctacacaaga ctccagggaa      180

gcacatggcc ttggactgaa ggctggcatc tggaagctgt cagccaccag caccttctgc      240

agcaggaaaa ggccagggct ctgctggagc aggcagcaga gtggacgcac agtaacatgg      300

gcaacttgaa gagcgtggcc caggagcctg ggccaccctg cggcctgggg ctggggctgg      360

gccttgggct gtgcggcaag cagggcccag ccaccccggc ccctgagccc agccgggccc      420

cagcatccct actcccacca gcgccagaac acagcccccc gagctccccg ctaacccagc      480

ccccagaggg gcccaagttc cctcgtgtga agaactggga ggtggggagc atcacctatg      540

acaccctcag cgcccaggcg cagcaggatg ggccctgcac cccaagacgc tgcctgggct      600

ccctggtatt tccacggaaa ctacagggcc ggccctcccc cggccccccg gcccctgagc      660

agctgctgag tcaggcccgg gacttcatca accagtacta cagctccatt aagaggagcg      720

gctcccaggc ccacgaacag cggcttcaag aggtggaagc cgaggtggca gccacaggca      780

cctaccagct tagggagagc gagctggtgt tcggggctaa gcaggcctgg cgcaacgctc      840

cccgctgcgt gggccggatc cagtggggga agctgcaggt gttcgatgcc cgggactgca      900

ggtctgcaca ggaaatgttc acctacatct gcaaccacat caagtatgcc accaaccggg      960

gcaaccttcg ctcggccatc acagtgttcc cgcagcgctg ccctggccga ggagacttcc     1020

gaatctggaa cagccagctg gtgcgctacg cgggctaccg gcagcaggat ggctctgtgc     1080

ggggggaccc agccaacgtg gagatcaccg agctctgcat tcagcacggc tggaccccag     1140

gaaacggtcg cttcgacgtg ctgcccctgc tgctgcaggc cccagatgat cccccagaac     1200

tcttccttct gccccccgag ctggtccttg aggtgcccct ggagcacccc acgctggagt     1260

ggtttgcagc cctgggcctg cgctggtacg ccctcccggc agtgtccaac atgctgctgg     1320

aaattggggg cctggagttc cccgcagccc ccttcagtgg ctggtacatg agcactgaga     1380

tcggcacgag gaacctgtgt gaccctcacc gctacaacat cctggaggat gtggctgtct     1440

gcatggacct ggatacccgg accacctcgt ccctgtggaa agacaaggca gcagtggaaa     1500

tcaacgtggc cgtgctgcac agttaccagc tagccaaagt caccatcgtg gaccaccacg     1560

ccgccacggc ctctttcatg aagcacctgg agaatgagca gaaggccagg gggggctgcc     1620

ctgcagactg ggcctggatc gtgcccccca tctcgggcag cctcactcct gttttccatc     1680

aggagatggt caactatttc ctgtccccgg ccttccgcta ccagccagac ccctggaagg     1740

ggagtgccgc caagggcacc ggcatcacca ggaagaagac ctttaaagaa gtggccaacg     1800

ccgtgaagat ctccgcctcg ctcatgggca cggtgatggc gaagcgagtg aaggcgacaa     1860

tcctgtatgg ctccgagacc ggccgggccc agagctacgc acagcagctg gggagactct     1920

tccggaaggc ttttgatccc cgggtcctgt gtatggatga gtatgacgtg gtgtccctcg     1980

aacacgagac gctggtgctg gtggtaacca gcacatttgg gaatggggat cccccggaga     2040

atggagagag ctttgcagct gccctgatgg agatgtccgg cccctacaac agctcccctc     2100

ggccggaaca gcacaagagt tataagatcc gcttcaacag catctcctgc tcagacccac     2160

tggtgtcctc ttggcggcgg aagaggaagg agtccagtaa cacagacagt gcaggggccc     2220

tgggcaccct caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg     2280

cctttgctcg tgccgtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc     2340

tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg     2400

ccttccaggc cgcctgtgag accttctgtg tgggagagga tgccaaggcc gccgcccgag     2460

acatcttcag ccccaaacgg agctggaagc gccagaggta ccggctgagc gcccaggccg     2520

agggcctgca gttgctgcca ggtctgatcc acgtgcacag gcggaagatg ttccaggcta     2580

caatccgctc agtggaaaac ctgcaaagca gcaagtccac gagggccacc atcctggtgc     2640

gcctggacac cggaggccag gaggggctgc agtaccagcc gggggaccac ataggtgtct     2700

gcccgcccaa ccggcccggc cttgtggagg cgctgctgag ccgcgtggag gacccgccgg     2760

cgcccactga gcccgtggca gtagagcagc tggagaaggg cagccctggt ggccctcccc     2820

ccggctgggt gcgggacccc cggctgcccc cgtgcacgct gcgccaggct ctcaccttct     2880

tcctggacat cacctcccca cccagccctc agctcttgcg gctgctcagc accttggcag     2940

aagagcccag ggaacagcag gagctggagg ccctcagcca ggatccccga cgctacgagg     3000

agtggaagtg gttccgctgc cccacgctgc tggaggtgct ggagcagttc ccgtcggtgg     3060

cgctgcctgc cccactgctc ctcacccagc tgcctctgct ccagccccgg tactactcag     3120

tcagctcggc acccagcacc cacccaggag agatccacct cactgtagct gtgctggcat     3180

acaggactca ggatgggctg ggccccctgc actatggagt ctgctccacg tggctaagcc     3240

agctcaagcc cggagaccct gtgccctgct tcatccgggg ggctccctcc ttccggctgc     3300

cacccgatcc cagcttgccc tgcatcctgg tgggtccagg cactggcatt gcccccttcc     3360

ggggattctg gcaggagcgg ctgcatgaca ttgagagcaa agggctgcag cccactccca     3420

tgactttggt gttcggctgc cgatgctccc aacttgacca tctctaccgc gacgaggtgc     3480

agaacgccca gcagcgcggg gtgtttggcc gagtcctcac cgccttctcc cgggaacctg     3540

acaaccccaa gacctacgtg caggacatcc tgaggacgga gctggctgcg gaggtgcacc     3600

gcgtgctgtg cctcgagcgg ggccacatgt ttgtctgcgg cgatgttacc atggcaacca     3660

acgtcctgca gaccgtgcag cgcatcctgg cgacggaggg cgacatggag ctggacgagg     3720

ccggcgacgt catcggcgtg ctgcgggatc agcaacgcta ccacgaagac attttcgggc     3780

tcacgctgcg cacccaggag gtgacaagcc gcatacgcac ccagagcttt tccttgcagg     3840

agcgtcagtt gcggggcgca gtgccctggg cgttcgaccc tcccggctca gacaccaaca     3900

gcccctgaga gccgcctggc tttcccttcc agttccggga gagcggctgc ccgactcagg     3960

tccgcccgac caggatcagc cccgctcctc ccctcttgag gtggtgcctt ctcacatctg     4020

tccagaggct gcaaggattc agcattattc ctccaggaag gagcaaaacg cctcttttcc     4080

ctctctaggc ctgttgcctc gggcctgggt ccgccttaat ctggaaggcc cctcccagca     4140

gcggtacccc agggcctact gccacccgct tcctgtttct tagtcgaatg ttagattcct     4200

cttgcctctc tcaggagtat cttacctgta aagtctaatc tctaaatcaa gtatttatta     4260

ttgaagattt accataaggg actgtgccag atgttaggag aactactaaa gtgcctaccc     4320

cagctcatgt ggattac                                                    4337


<210>  53
<211>  1593
<212>  DNA
<213>  Homo sapiens

<400>  53
gcggtgccct tgcggcgcag ctggggtcgc ggccctgctc cccgcgcttt cttaaggccc       60

gcgggcggcg caggagcggc actcgtggct gtggtggctt cggcagcggc ttcagcagat      120

cggcggcatc agcggtagca ccagcactag cagcatgttg agccgggcag tgtgcggcac      180

cagcaggcag ctggctccgg ttttggggta tctgggctcc aggcagaagc acagcctccc      240

cgacctgccc tacgactacg gcgccctgga acctcacatc aacgcgcaga tcatgcagct      300

gcaccacagc aagcaccacg cggcctacgt gaacaacctg aacgtcaccg aggagaagta      360

ccaggaggcg ttggccaagg gagatgttac agcccagata gctcttcagc ctgcactgaa      420

gttcaatggt ggtggtcata tcaatcatag cattttctgg acaaacctca gccctaacgg      480

tggtggagaa cccaaagggg agttgctgga agccatcaaa cgtgactttg gttcctttga      540

caagtttaag gagaagctga cggctgcatc tgttggtgtc caaggctcag gttggggttg      600

gcttggtttc aataaggaac ggggacactt acaaattgct gcttgtccaa atcaggatcc      660

actgcaagga acaacaggcc ttattccact gctggggatt gatgtgtggg agcacgctta      720

ctaccttcag tataaaaatg tcaggcctga ttatctaaaa gctatttgga atgtaatcaa      780

ctgggagaat gtaactgaaa gatacatggc ttgcaaaaag taaaccacga tcgttatgct      840

gagtatgtta agctctttat gactgttttt gtagtggtat agagtactgc agaatacagt      900

aagctgctct attgtagcat ttcttgatgt tgcttagtca cttatttcat aaacaactta      960

atgttctgaa taatttctta ctaaacattt tgttattggg caagtgattg aaaatagtaa     1020

atgctttgtg tgattgaatc tgattggaca ttttcttcag agagctaaat tacaattgtc     1080

atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt     1140

tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa     1200

taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt     1260

gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt     1320

caaatgttcc tgtatagttt ttgcaaatag agctgtatac tgtttaaatg tagcaggtga     1380

actgaactgg ggtttgctca cctgcacagt aaaggcaaac ttcaacagca aaactgcaaa     1440

aaggtggttt ttgcagtagg agaaaggagg atgtttattt gcagggcgcc aagcaaggag     1500

aattgggcag ctcatgcttg agacccaatc tccatgatga cctacaagct agagtattta     1560

aaggcagtgg taaatttcag gaaagcagaa gtt                                  1593


<210>  54
<211>  1528
<212>  DNA
<213>  Homo sapiens

<400>  54
ggggaggtct ggcctgcttt tcctccctga actggcccaa tgactggctc cctcacgctg       60

accactcctc tgggctggcc tcctgcactc gcgctaacag cccaggctcc agggacagcc      120

tgcgttcctg ggctggctgg gtgcagctct cttttcagga gagaaagctc tcttggagga      180

gctggaaagg tgcccgactc cagccatgct ggcgctactg tgttcctgcc tgctcctggc      240

agccggtgcc tcggacgcct ggacgggcga ggactcggcg gagcccaact ctgactcggc      300

ggagtggatc cgagacatgt acgccaaggt cacggagatc tggcaggagg tcatgcagcg      360

gcgggacgac gacggcgcgc tccacgccgc ctgccaggtg cagccgtcgg ccacgctgga      420

cgccgcgcag ccccgggtga ccggcgtcgt cctcttccgg cagcttgcgc cccgcgccaa      480

gctcgacgcc ttcttcgccc tggagggctt cccgaccgag ccgaacagct ccagccgcgc      540

catccacgtg caccagttcg gggacctgag ccagggctgc gagtccaccg ggccccacta      600

caacccgctg gccgtgccgc acccgcagca cccgggcgac ttcggcaact tcgcggtccg      660

cgacggcagc ctctggaggt accgcgccgg cctggccgcc tcgctcgcgg gcccgcactc      720

catcgtgggc cgggccgtgg tcgtccacgc tggcgaggac gacctgggcc gcggcggcaa      780

ccaggccagc gtggagaacg ggaacgcggg ccggcggctg gcctgctgcg tggtgggcgt      840

gtgcgggccc gggctctggg agcgccaggc gcgggagcac tcagagcgca agaagcggcg      900

gcgcgagagc gagtgcaagg ccgcctgagc gcggccccca cccggcggcg gccagggacc      960

cccgaggccc ccctctgcct ttgagcttct cctctgctcc aacagacacc ctccactctg     1020

aggtctcacc ttcgcctttg ctgaagtctc cccgcagccc tctccaccca gaggtctccc     1080

tataccgaga cccaccatcc ttccatcctg aggaccgccc caaccctcgg agccccccac     1140

tcagtaggtc tgaaggcctc catttgtacc gaaacacccc gctcacgctg acagcctcct     1200

aggctccctg aggtaccttt ccacccagac cctccttccc caccccataa gccctgagac     1260

tcccgccttt gacctgacga tcttccccct tcccgccttc aggttcctcc taggcgctca     1320

gaggccgctc tggggggttg cctcgagtcc ccccacccct ccccacccac caccgctccc     1380

gcggcaagcc agcccgtgca acggaagcca ggccaactgc cccgcgtctt cagctgtttc     1440

gcatccaccg ccaccccact gagagctgct cctttggggg aatgtttggc aacctttgtg     1500

ttacagatta aaaattcagc aattcagt                                        1528


