                         SEQUENCE LISTING

<110>  Rottapharm Biotech S.r.l.
       VISINTIN, Michela
       CASELLI, Gianfranco
       CHIUSAROLI, Riccardo
       ROVATI, Lucio Claudio
 
<120>  anti-ADAMTS-5 antibody, derivatives and uses thereof

<130>  PCT 120045

<150>  EP12164107.0
<151>  2012-04-13

<160>  216   

<170>  PatentIn version 3.5

<210>  1
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp 
1               5                   10                  15      


Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser 
            20                  25                  30          


Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser 
        35                  40                  45              


Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro 
    50                  55                  60                  


Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg 
65                  70                  75                  80  


Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu 
                85                  90                  95      


Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu 
            100                 105                 110         


Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu 
        115                 120                 125             


Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp 
    130                 135                 140                 


Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu 
145                 150                 155                 160 


His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro 
                165                 170                 175     


Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro 
            180                 185                 190         


Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg 
        195                 200                 205             


Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg 
225                 230                 235                 240 


Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro 
                245                 250                 255     


Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu 
            260                 265                 270         


Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr 
        275                 280                 285             


Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp 
    290                 295                 300                 


Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly 
            340                 345                 350         


Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu 
    370                 375                 380                 


Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro 
385                 390                 395                 400 


Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu 
                405                 410                 415     


Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu 
            420                 425                 430         


His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln 
        435                 440                 445             


Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro 
    450                 455                 460                 


Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala 
465                 470                 475                 480 


Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly 
                485                 490                 495     


Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu 
            500                 505                 510         


Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro 
        515                 520                 525             


Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
545                 550                 555                 560 


Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr 
                565                 570                 575     


Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His 
            580                 585                 590         


Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro 
        595                 600                 605             


Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln 
    610                 615                 620                 


Ala Gln Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp 
625                 630                 635                 640 


Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg 
                645                 650                 655     


Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe 
            660                 665                 670         


Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln 
        675                 680                 685             


Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr 
    690                 695                 700                 


Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro 
705                 710                 715                 720 


Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr 
                725                 730                 735     


Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val 
            740                 745                 750         


Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser 
        755                 760                 765             


Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln 
    770                 775                 780                 


Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe 
785                 790                 795                 800 


Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp 
                805                 810                 815     


Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro 
            820                 825                 830         


Trp Ala Gly Arg Lys 
        835         


<210>  2
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  3
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Pro Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      


Val Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Asp Leu Gly Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  5
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Gln Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Pro Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Glu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110 


<210>  6
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Thr Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Ile Cys Gln Gln Tyr Cys Ser His Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Pro Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala His Gly Arg Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Tyr Ser Tyr Ala Ile Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly Asn Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val His Gly Gly Ser Phe Ser Gly Asn 
            20                  25                  30          


Phe Trp Ser Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Asn His Arg Gly Ser Ala Thr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Leu Pro Arg Arg Arg Ala Glu Asp Arg Pro Ser Ser Leu Arg 
            100                 105                 110         


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  11
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110         


<210>  12
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Ser His 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Gly Thr Val Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Thr Arg Tyr Cys Ser Arg Thr Ser Cys His Ser Gly Tyr 
            100                 105                 110         


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Thr Ser Leu Lys Thr Asp Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Ala Ser Asp Ala Phe Gly Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Arg Arg 
                85                  90                  95      


Ser Thr Leu Glu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  16
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Ile Trp Ser Thr Arg His Asp Phe Trp Ser Gly Tyr Tyr Ser 
            100                 105                 110         


Ser Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  17
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 
1               5                   10                  15      


Asp Lys Ile Tyr Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 
        35                  40                  45              


Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Met Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Pro Gln Gln Asp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  18
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Ser Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Val Ser Gly Tyr Arg Leu Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Met Thr Glu Asp Thr Ser Thr Asp Ser Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser Trp 
            100                 105                 110         


Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Thr Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Thr Val Gly Ser Lys Gly Asp Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Ile Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Thr Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Ser Asn Phe Val Tyr Val Phe Gly Ser Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  20
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asp Leu Leu His Lys Asp Gly Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Gly Ile Gly Lys Tyr 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Pro Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Asp 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Arg Asn Thr Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Thr Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Phe Asp Gly Thr Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Ser Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Glu Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


His Asp Tyr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Gly Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Ser Asp Asp 
                85                  90                  95      


Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  24
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ser Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Val Ser Gly Tyr Arg Leu Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Met Thr Glu Asp Thr Ser Thr Asp Ser Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser Trp 
            100                 105                 110         


Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Arg Gln Tyr His Ser Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  26
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Glu Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Ser Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Val Glu Lys Leu Tyr Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  27
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  27

Arg Ser Ser Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  28
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  28

Leu Met Ser Thr Arg Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Gln Gln Leu Val Glu Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  30

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Gln Asn Asn Glu Glu Leu Thr 
1               5               


<210>  33
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  33

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  34

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Gln Tyr Cys Ser His Pro Tyr Thr 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Ala Ser Gln Ala Ile Gly Asn Asp Leu Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Ala Ser Thr Leu Ser Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Gln Tyr Asn Asn Phe Pro Tyr Thr 
1               5                   


<210>  39
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  39

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  40
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Asn Asp Asn Arg Pro Ser 
1               5           


<210>  41
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Ser Tyr Asp Asn Ser Leu Ser Gly Tyr Ala Val 
1               5                   10          


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  45
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  45

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Ser Tyr Thr Arg Arg Ser Thr Leu Glu 
1               5                   10  


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Ala Ser Gln Asp Ile Asp Asp Asp Met Asn 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Ala Thr Thr Leu Val Pro 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Pro Gln Gln Asp Asn Val Pro Leu Thr 
1               5                   


<210>  51
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys Val Asp 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  52

Val Gly Thr Gly Gly Thr Val Gly Ser Lys Gly Asp 
1               5                   10          


<210>  53
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val Tyr Val 
1               5                   10              


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  54

Arg Pro Ser Gln Gly Ile Gly Lys Tyr Ser Ala 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  55

Leu Ala Ser Thr Leu Gln Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Gln Arg Asn Thr Tyr Pro Trp Thr 
1               5                   


<210>  57
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  57

Ser Gly Asp Lys Leu Glu Asp Lys Tyr Ala Cys 
1               5                   10      


<210>  58
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  58

His Asp Tyr Lys Arg Pro Ser 
1               5           


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Val Trp Asp Ser Gly Ser Asp Asp Gln Val 
1               5                   10      


<210>  60
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  60

Ser Tyr Trp Met His 
1               5   


<210>  61
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  61

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  62
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  62

Gly Gly Tyr Asp Asp Leu Gly Tyr 
1               5               


<210>  63
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  63

Arg Tyr Trp Met Ser 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  64

Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  65
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  65

Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5               


<210>  66
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  66

Asp Thr Tyr Met His 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  67

Arg Ile Asp Pro Ala His Gly Arg Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  68

Tyr Ser Tyr Ala Ile Asp Tyr 
1               5           


<210>  69
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Asn Phe Trp Ser 
1               5   


<210>  70
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Val Asn His Arg Gly Ser Ala Thr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  71
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  71

Lys Leu Pro Arg Arg Arg Ala Glu Asp Arg Pro Ser Ser Leu Arg Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  72
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser His Asp Met His 
1               5   


<210>  73
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  73

Arg Ile Gly Thr Val Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  74
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Gly Thr Arg Tyr Cys Ser Arg Thr Ser Cys His Ser Gly Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val 
            20          


<210>  75
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  75

Asp His Tyr Met Asp 
1               5   


<210>  76
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  76

Arg Ile Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  77
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Leu Gly Ala Ser Asp Ala Phe Gly Leu 
1               5                   10  


<210>  78
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Tyr Tyr Trp Ser 
1               5   


<210>  79
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  80
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  80

Thr Ile Trp Ser Thr Arg His Asp Phe Trp Ser Gly Tyr Tyr Ser Ser 
1               5                   10                  15      


Asn Trp Phe Asp Pro 
            20      


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Tyr Pro Ile His 
1               5   


<210>  82
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  82

Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser 
1               5                   10              


<210>  84
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Tyr Ala Met Thr 
1               5   


<210>  85
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  85

Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Arg Asp Leu Leu His Lys Asp Gly Phe Asp Ile 
1               5                   10          


<210>  87
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Tyr Gly Met Asn 
1               5   


<210>  88
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  88

Thr Ile Ser Phe Asp Gly Thr Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  89

Asp Trp Ser Tyr Ala Met Asp Val 
1               5               


<210>  90
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Tyr Pro Ile His 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  91

Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  92

Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser 
1               5                   10              


<210>  93
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  93

Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg 
1               5                   10                  15      


Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala 
            20                  25                  30          


Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys 
        35                  40                  45              


Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg 
    50                  55                  60                  


Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly 
65                  70                  75                  80  


Arg Val Ala Ala Gly Glu Pro Leu Leu Ala Gln Gln His Ile Glu Gly 
                85                  90                  95      


His Tyr Gln Val Asp Pro Ser Leu Phe Lys Pro Asn Ala Asp Phe Leu 
            100                 105                 110         


Leu Arg Val Ser Gly Met Ser Met Lys Asp Ile Gly Ile Met Asp Gly 
        115                 120                 125             


Asp Leu Leu Ala Val His Lys Thr Gln Asp Val Arg Asn Gly Gln Val 
    130                 135                 140                 


Val Val Ala Arg Ile Asp Asp Glu Val Thr Val Lys Arg Leu Lys Lys 
145                 150                 155                 160 


Gln Gly Asn Lys Val Glu Leu Leu Pro Glu Asn Ser Glu Phe Lys Pro 
                165                 170                 175     


Ile Val Val Asp Leu Arg Gln Gln Ser Phe Thr Ile Glu Gly Leu Ala 
            180                 185                 190         


Val Gly Val Ile Arg Asn Gly Asp Trp Leu Glu Phe Thr Lys Ile Val 
        195                 200                 205             


Gly Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile 
    210                 215                 220                 


Pro Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp 
225                 230                 235                 240 


Gln Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu 
                245                 250                 255     


Tyr Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile 
            260                 265                 270         


Asp Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp 
        275                 280                 285             


Asp Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile 
    290                 295                 300                 


Val Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr 
305                 310                 315                 320 


Ser Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr 
                325                 330                 335     


Ser His Gly Ser Asn Lys Val Gly Ser His Thr Lys Ile Tyr Ala Ile 
            340                 345                 350         


<210>  94
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  94

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Asp Asp Asp Asp Lys Ser Pro Met Val Thr Lys Ile Val Gly Thr Phe 
        275                 280                 285             


Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro Glu Gly 
    290                 295                 300                 


Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln Thr Arg 
305                 310                 315                 320 


Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr Leu Ile 
                325                 330                 335     


Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp Ile Asn 
            340                 345                 350         


Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp Phe Leu 
        355                 360                 365             


His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val Gln Ile 
    370                 375                 380                 


Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser Phe Phe 
385                 390                 395                 400 


Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser His Gly 
                405                 410                 415     


Ser Asn Lys Val Gly Ser His Thr 
            420                 


<210>  95
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  95
atggaatggt ccggcgtgtt catgttcctg ctgtccgtga ccgctggcgt gcactccgac       60

atcgtgctga cccagtcccc cgccatcatg tctgcctccc tgggcgagcg cgtgacaatg      120

acctgcaccg cctcctccag cgtgtcctcc tcctacctgc actggtatca gcagaagccc      180

ggctccagcc ccaagctgtg gatctactcc acctccaacc tggcctccgg cgtgcccgcc      240

agattctctg gctccggctc cggcacctcc tactccctga ccatctccag catggaagcc      300

gaggacgccg ccacctacta ctgtcggcag taccactcct acccctggac cttcggcgga      360

ggcaccaagc tggaaatcaa gcggaccgtg gccgctccct ccgtgttcat cttcccaccc      420

tccgacgagc agctgaagtc cggcaccgcc agcgtcgtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      540

gaatccgtca ccgagcagga ctccaaggac agcacctaca gcctgagttc caccctgacc      600

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      660

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gctgataa                   708


<210>  96
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  96
atggaatggt ccggcgtgtt catgttcctg ctgtccgtga ccgctggcgt gcactcccag       60

gtgcagctgc agcagtccgg ccctgagctg gtcaagcctg gcgcctccgt ggaaatgtcc      120

tgcaaggcct ccggctacac cttcaccagc tacgtgatgc actgggtcaa gcagaagccc      180

ggccaggacc tggaatggat cggctacatc aacccctact ccgacggcac caagtacaac      240

gagaagttca agggcaaggc caccctgacc tccgacaagt cctcctccac cgcctacatg      300

gaactgtcct ccctgaccag cgaggactcc gccgtgtact actgcgccac caccgtggaa      360

aagctgtact ccgactactg gggccagggc accacactga ccgtgtcctc tgcctccacc      420

aagggccctt ccgtgttccc tctggcccct tgctcccggt ccacctctga gtctaccgcc      480

gctctgggct gcctggtgaa agactacttc cccgagcccg tgaccgtgtc ctggaactcc      540

ggcgctctga cctccggcgt gcacaccttc cctgccgtgc tgcagtccag cggcctgtac      600

tccctgtcct ccgtggtgac cgtgccttcc tccagcctgg gcaccaagac ctacacctgt      660

aacgtggacc acaagccctc caacaccaag gtggacaagc gggtggaatc taagtacggc      720

ccaccctgcc ccccctgccc tgctcctgag tttctgggcg gaccctccgt gttcctgttc      780

cccccaaagc ccaaggatac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      840

gtggacgtgt cccaggaaga tcccgaggtc cagttcaatt ggtacgtgga cggcgtggaa      900

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccaccta ccgggtggtg      960

tctgtgctga cagtgctgca tcaggactgg ctgaacggca aagagtacaa gtgcaaagtc     1020

tccaacaagg gactgccctc cagcatcgaa aagaccatct ccaaggccaa gggccagccc     1080

cgcgagcctc aggtgtacac cctgccacct agccaggaag agatgaccaa gaaccaggtg     1140

tccctgacct gtctggtgaa aggcttctac ccctccgaca tcgccgtgga atgggagtct     1200

aacggccagc ccgagaacaa ctacaagacc acaccccctg tgctggactc cgacggctcc     1260

ttcttcctgt actctcggct gacagtggac aagtcccggt ggcaggaagg caacgtcttc     1320

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1380

agcctgggca agtgataa                                                   1398


<210>  97
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  97
atggaatggt ccggcgtgtt catgttcctg ctgtccgtga ccgctggcgt gcactccgac       60

atcgtgatca cccaggacga gctgtccaac cccgtgacct ccggcgagtc cgtgtccatc      120

tcctgccggt cctccaagtc cctgctgtac aaggacggca agacctacct gtactggttc      180

ctgcagcggc ctggccagtc cccccagctg cccatctacc tgatgtccac ccgggccagc      240

ggcgtgtccg acagattctc cggctccggc agcggcaccg actttaccct ggaaatctcc      300

agagtgaagg ccgaggacgt gggcgtgtac tactgccagc agctggtgga atacccctac      360

accttcggcg gaggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttc      420

atcttcccac cctccgacga gcagctgaag tccggcaccg cctccgtcgt gtgcctgctg      480

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagtcc      540

ggcaactccc aggaatccgt caccgagcag gactccaagg acagcaccta ctccctgtcc      600

tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      660

acccaccagg gcctgtccag ccctgtgacc aagtccttca accggggcga gtgctgataa      720


<210>  98
<211>  1393
<212>  DNA
<213>  Homo sapiens

<400>  98
atggaatggt ccggcgtgtt catgttcctg ctgtccgtga ccgctggcgt gcactcccag       60

gtgcagctgc agcagtctgg cgccgagctg gctaagcctg gcgcctccgt gaagatgtcc      120

tgcaaggcct ccggctacac cttcaccagc tactggatgc actgggtcaa gcagcggcct      180

ggccagggcc tggaatggat cggctacatc aacccctcca ccggctatac cgagtacaac      240

cagaagttca aggacaaggc caccctgacc gccgacaagt cctcctccac cgcctacatg      300

cagctgggct ccctgacctc cgaggactcc gccgtgtact actgcgccag aggcggctac      360

gacgacctgg gatactgggg ccagggcacc acactgaccg tgtcctctgc ctccaccaag      420

ggcccttccg tgttccctct ggccccttgc tcccggtcca cctctgagtc taccgccgct      480

ctgggctgcc tggtgaaaga ctacttcccc gagcccgtga ccgtgtcctg gaactccggc      540

gctctgacct ccggcgtgca caccttccct gccgtgctgc agtccagcgg cctgtactcc      600

ctgtcctccg tggtgaccgt gccttcctcc agcctgggca ccaagaccta cacctgtaac      660

gtggaccaca agccctccaa caccaaggtg gacaagcggg tggaatctaa gtacggccca      720

ccctgccccc cctgccctgc tcctgagttt ctgggcggac cctccgtgtt cctgttcccc      780

ccaaagccca aggataccct gatgatctcc cggacccccg aagtgacctg cgtggtggtg      840

gacgtgtccc aggaagatcc cgaggtccag ttcaattggt acgtggacgg cgtggaagtg      900

cacaacgcca agaccaagcc cagagaggaa cagttcaact ccacctaccg ggtggtgtct      960

gtgctgacag tgctgcatca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1020

aacaagggac tgccctccag catcgaaaag accatctcca aggccaaggg ccagccccgc     1080

gagcctcagg tgtacaccct gccacctagc caggaagaga tgaccaagaa ccaggtgtcc     1140

ctgacctgtc tggtgaaagg cttctacccc tccgacatcg ccgtggaatg ggagtctaac     1200

ggccagcccg agaacaacta caagaccaca ccccctgtgc tggactccga cggctccttc     1260

ttcctgtact ctcggctgac agtggacaag tcccggtggc aggaaggcaa cgtcttctcc     1320

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gtccctgagc     1380

ctgggcaagt gat                                                        1393


<210>  99
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  99
gacattgtga taactcagga tgaactctcc aatcctgtca cttctggaga atcagtttcc       60

atctcctgca ggtctagtaa gagtctccta tataaggatg ggaagacata cttgtattgg      120

tttctgcaga gaccaggaca atctcctcag ctcccgatct atttgatgtc cacccgtgca      180

tcaggagtct cagaccggtt tagtggcagt gggtcaggaa cagatttcac cctggaaatc      240

agtagagtga aggctgagga tgtgggtgtg tattactgtc aacaacttgt agagtatccg      300

tacacgttcg gaggggggac caagctggaa atcaaa                                336


<210>  100
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  100
caggttcagc tgcagcagtc tggggctgag ctggcaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcactggtta tactgagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcaactgg gcagcctgac atctgaggac tctgcagtct attactgtgc aagagggggg      300

tatgatgatc ttggctactg gggccaaggc accactctca cagtctcctc a               351


<210>  101
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  101
gacattgtga tgacccaatc tccagcttct ttggctgtgt ctcaagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc cccatctatc ttgcttccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggagctcacg      300

ttcggtgctg ggaccaagct ggagctgaaa                                       330


<210>  102
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  102
gaagtgaagc ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtacaa cctcaggatt cgactttagt agatactgga tgagttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat      180

acgccatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgtac      240

ctgcaaatga gcaaagtgag atctgaggac acagcccttt attactgtgc aagaaggagc      300

tactggtact tcgatgtctg gggcgcaggg acctcagtca ccgtctcctc a               351


<210>  103
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  103
gacattgtga tgacacagtc tcacaaattc atgtccacat cagaaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

ggccaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattatat ctgtcagcaa tattgcagcc atccgtacac gttcggtgct      300

gggaccaagc tggaaatcaa a                                                321


<210>  104
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  104
caagttcagc tgcagcagtc tggggcagaa cctgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tgcactgggt gaaacagagg      120

cctgaacagg gcctggaatg gattggaagg attgatcctg cgcatggcag aactaaatat      180

gacccgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac      240

ctgcaactca gcagcctgtc atctgaggac actgccgtct attactgtgc tttttactcc      300

tatgctattg actactgggg tcagggaacc tcagtcaccg tctcctca                   348


<210>  105
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  105
gatattgtga tgactcagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggccattggc aatgatttag cctggtatca gcagagacca      120

gggaaagccc ctaagcgcct gatctatggt gcatccactt tgtccagtgg ggtcccatca      180

cgattcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tataataatt tcccctacac ttttggcctg      300

gggaccaagg tggaaatcaa a                                                321


<210>  106
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  106
caggtgcagc tacagcagtg gggcgcaggg ctgttgaagc cctcggagac cctgtccctc       60

acctgcgctg tgcatggtgg gtccttcagt ggtaacttct ggagctgggt ccgccaacac      120

ccagggaagg gactggagtg gatcggggaa gtcaatcatc gtggaagcgc cacctacaac      180

ccgtcactca agagtcgagt caccatgtca gttgacacat ccaagaatca gttctccctg      240

caattgagct ctgtgaccgc cgcggacacg gctgtctatt actgtgcgag aaagcttcca      300

agacgacggg cggaggaccg accctcgagt ttacggccgt ttgactactg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210>  107
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  107
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaatg acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acaacagcct gagtggctat      300

gctgtgttcg gaggaggcac ccagctgacc gtcctc                                336


<210>  108
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  108
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caggttctcc agccacgaca tgcactgggt ccgccaagtt      120

ccaggaaaag gtctggagtg ggtctcacgt attgggactg ttggtgacac atactacgca      180

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtttctg      240

caaatgaaca gcctgggagc cgaggacacg gccgtgtatt actgtgcgag agatggtacc      300

cgttattgta gtagaaccag ctgccacagc ggctactact actacggtat ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210>  109
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  109
gatattgtga tgacccagac tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210>  110
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  110
caggtgcagc tggtgcagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctccggatt caccttcagt gaccactaca tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attagaaaca aagctaacag ttacaccaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc aaagaaaaca      240

ctgtatctgc aaatgaccag cctgaaaacc gacgacacgg ccctttatta ttgtgctaga      300

gatctggggg cctctgatgc ttttggtctc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  111
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  111
cagtctgtct tgacgcagcc gccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcttgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctagtcgct tctctggctc caagtctggc aactcggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagaaggag cactctggag      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  112
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  112
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggggac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aaccatatgg      300

agcacccgac acgatttttg gagtggttat tattcctcca actggttcga cccctggggc      360

cagggaaccc tggtcaccgt ctcctca                                          387


<210>  113
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  113
gaaacgacac tcacgcagtc tccagcattc atgtcggcga ctccaggaga caaaatctat       60

atctcctgca aagccagcca agacattgat gatgatatga actggtacca acagaaacca      120

ggagaagctg ctattttcat tattcaagaa gctactactc tcgttcctgg aatcccacct      180

cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catggaatct      240

gaggatgctg catattactt ctgtccacaa caagataatg tccccctcac tttcggcgga      300

gggaccaagg tggatatcaa a                                                321


<210>  114
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  114
gaggtgcagc tggtggagtc tgggtctgac gtgaagaagc cgggggcctc agtgagggtc       60

tcctgcaaag tttccggata cagactcact gagtatccca tacactgggt tcgacaggcg      120

ccggggaaag gacttgagta catgggaggc tttgatcttg aaaatggtgt aacaaaggcc      180

gcaccgaggt tcaggggcag attcaccatg accgaggaca catctacaga ctctgtttat      240

atggagttga agagcctgac atctgaagac acggccgtct attattgtgt aaaggggccg      300

ggatacggtg cgttggtgac ctcctttacc tcctggggcc tgggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  115
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  115
cagtctgtgt tgacgcagcc gccttctgca tcagcctccc tgggagcctc ggtcacactc       60

acctgcaccc tgagcagcgg ctacagtaat tataaagtgg actggtacca acagacacca      120

gggaagggcc cccggtttgt gatgcgagtg ggcactggtg ggactgtggg atccaagggg      180

gatggcatcc ctgatcgctt ctcagtcttg ggctcaggcc tgaatcggta cctgatcatc      240

aagaacatcc aggaagagga tgagactgac taccactgtg gggcagacca tggcagtggg      300

agcaacttcg tgtatgtctt cggaagtggg accaaggtca ccgtccta                   348


<210>  116
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  116
caggtgcagc tgcaggagtc ggggggaggc ttggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgatag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatgg acagcctgag agtcgaggac acggctgtgt attactgtgc gagagatcgc      300

gatctcctgc acaaagatgg ttttgatatc tggggccaag ggacaatggt caccgtctct      360

tca                                                                    363


<210>  117
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  117
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgttggaga cagagtcacc       60

atcacttgtc ggccgagtca gggaattggc aagtactcag cctggtatca gcagaaacca      120

gggaaagccc ctgagctccc gatctatctt gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg acagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cgtaatactt acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  118
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  118
caggtgcagc tgcaggagtc ggggggaggc gtggtccagc ctgggaggtc cctgaggctc       60

tcctgtgcgg cctctgggtt caccttcagt ggctatggca tgaactgggt ccgccaggct      120

ccaggcacgg ggctggagtg ggtggcaaca atatcatttg atggaactga taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgctgagaa cacgctctat      240

ctgcaaatga acagtctgag agccgaggac atggctgtgt attactgtgc aagagattgg      300

tcgtacgcga tggacgtctg gggccaaggg acaatggtca ccgtctcttc a               351


<210>  119
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  119
tcctatgtgc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt ggaggataaa tacgcttgct ggtatcagca gaagccaggc      120

cagtcccctg tgctggtcat ctatcatgat tacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc accctgacca tcagcagggt cgaaggcggg      240

gatgaggccg actattactg tcaggtgtgg gatagcggta gtgatgatca ggtcttcggc      300

ggagggacca agctgaccgt ccta                                             324


<210>  120
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  120
caggtgcagc tggtgcagtc tgggtctgac gtgaagaagc cgggggcctc agtgagggtc       60

tcctgcaaag tttccggata cagactcact gagtatccca tacactgggt tcgacaggcg      120

ccggggaaag gacttgagta catgggaggc tttgatcttg aaaatggtgt aacaaaggcc      180

gcaccgaggt tcaggggcag attcaccatg accgaggaca catctacaga ctctgtttat      240

atggagttga agagcctgac atctgaagac acggccgtct attattgtgt aaaggggccg      300

ggatacggtg cgttggtgac ctcctttacc tcctggggcc tggggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  121
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  121

Thr Lys Ile Val Gly Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp 
1               5                   10                  15      


Val Val Arg Ile Pro Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe 
            20                  25                  30          


Lys Ala Lys Asp Gln Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys 
        35                  40                  45              


Lys Asn Gly Glu Tyr Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser 
    50                  55                  60                  


Glu Thr Ile Ile Asp Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp 
65                  70                  75                  80  


Ser His Arg Asp Asp Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys 
                85                  90                  95      


Glu Ile Leu Ile Val Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu 
            100                 105                 110         


Asp Val Arg Tyr Ser Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val 
        115                 120                 125             


Asn Ser Val Thr Ser His Gly Ser Asn Lys Val Gly Ser His Thr 
    130                 135                 140             


<210>  122
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  122

Asn Ala Ala Thr Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His 
1               5                   10                  15      


Asn 
    


<210>  123
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  123
acaaagattg ttggaacctt taataagaaa agtaagggtt acactgacgt ggtgaggatt       60

cctgaagggg caacccacat aaaagttcga cagttcaaag ccaaagacca gactagattc      120

actgcctatt tagccctgaa aaagaaaaac ggtgagtacc ttatcaatgg aaagtacatg      180

atctccactt cagagactat cattgacatc aatggaacag tcatgaacta tagcggttgg      240

agccacaggg atgacttcct gcatggcatg ggctactctg ccacgaagga aattctaata      300

gtgcagattc ttgcaacaga ccccactaaa ccattagatg tccgttatag cttttttgtt      360

cccaagaagt ccactccaaa agtaaactct gtcactagtc atggcagcaa taaagtggga      420

tcacacact                                                              429


<210>  124
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  124
aacgctgcca ccacactcaa gaacttttgc aagtggcagc accaacacaa c                51


<210>  125
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  125

Asp Ile Val Ile Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Pro Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      


Val Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ser Gly Gly Ser Thr Arg Gly Ser Gly Lys Pro Gly Ser Gly Glu 
        115                 120                 125             


Gly Ser Ser Gly Thr Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
    130                 135                 140                 


Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
145                 150                 155                 160 


Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln 
                165                 170                 175     


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu 
            180                 185                 190         


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser 
        195                 200                 205             


Ser Ser Thr Ala Tyr Met Gln Leu Gly Ser Leu Thr Ser Glu Asp Ser 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Asp Asp Leu Gly Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250 


<210>  126
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  126

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Gln Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Pro Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Glu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser 
            100                 105                 110         


Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser 
        115                 120                 125             


Ser Gly Thr Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Thr Thr Ser Gly Phe Asp Phe 
145                 150                 155                 160 


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr 
            180                 185                 190         


Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
225                 230                 235                 240 


Gly Thr Ser Val Thr Val Ser Ser 
                245             


<210>  127
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  127

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Ile Cys Gln Gln Tyr Cys Ser His Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ser Gly Gly Ser 
            100                 105                 110         


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Arg Gly Thr 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Pro Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
145                 150                 155                 160 


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Arg Ile Asp Pro Ala His Gly Arg Thr Lys Tyr Asp Pro Lys Phe 
            180                 185                 190         


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
        195                 200                 205             


Leu Gln Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Phe Tyr Ser Tyr Ala Ile Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  128
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  128

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly Asn Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ser Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys Ser Gly Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Thr Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Ala Val His Gly Gly Ser Phe Ser Gly Asn Phe 
145                 150                 155                 160 


Trp Ser Trp Val Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Glu Val Asn His Arg Gly Ser Ala Thr Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Lys Leu Pro Arg Arg Arg Ala Glu Asp Arg Pro Ser Ser Leu Arg Pro 
225                 230                 235                 240 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  129
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  129

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110         


Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
        115                 120                 125             


Ser Ser Gly Thr Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg 
145                 150                 155                 160 


Phe Ser Ser His Asp Met His Trp Val Arg Gln Val Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Arg Ile Gly Thr Val Gly Asp Thr Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Phe Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Asp Gly Thr Arg Tyr Cys Ser Arg Thr Ser Cys 
225                 230                 235                 240 


His Ser Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser 
            260         


<210>  130
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  130

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Thr Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His Tyr 
145                 150                 155                 160 


Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
                165                 170                 175     


Arg Ile Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Lys Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Thr Ser Leu Lys Thr Asp Asp Thr Ala Leu Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Leu Gly Ala Ser Asp Ala Phe Gly Leu Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser 
                245             


<210>  131
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  131

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Arg Arg 
                85                  90                  95      


Ser Thr Leu Glu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser 
        115                 120                 125             


Gly Thr Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro 
    130                 135                 140                 


Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser 
145                 150                 155                 160 


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Thr Ile Trp Ser Thr Arg His Asp Phe Trp Ser Gly Tyr 
225                 230                 235                 240 


Tyr Ser Ser Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  132
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Ser Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Val Ser Gly Tyr Arg Leu Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Met Thr Glu Asp Thr Ser Thr Asp Ser Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser Trp 
            100                 105                 110         


Gly Leu Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Thr Glu Thr 
    130                 135                 140                 


Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly Asp Lys 
145                 150                 155                 160 


Ile Tyr Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp Met Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile Gln Glu 
            180                 185                 190         


Ala Thr Thr Leu Val Pro Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Met Glu Ser Glu Asp 
    210                 215                 220                 


Ala Ala Tyr Tyr Phe Cys Pro Gln Gln Asp Asn Val Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Asp Ile Lys 
                245                 


<210>  133
<211>  2793
<212>  DNA
<213>  Homo sapiens

<400>  133
atgctgctcg ggtgggcgtc cctgctgctg tgcgcgttcc gcctgcccct ggccgcggtc       60

ggccccgccg cgacacctgc ccaggataaa gccgggcagc ctccgactgc tgcagcagcc      120

gcccagcccc gccggcggca gggggaggag gtgcaggagc gagccgagcc tcccggccac      180

ccgcaccccc tggcgcagcg gcgcaggagc aaggggctgg tgcagaacat cgaccaactc      240

tactccggcg gcggcaaggt gggctacctc gtctacgcgg gcggccggag gttcctcttg      300

gacctggagc gagatggttc ggtgggcatt gctggcttcg tgcccgcagg aggcgggacg      360

agtgcgccct ggcgccaccg gagccactgc ttctatcggg gcacagtgga cgctagtccc      420

cgctctctgg ctgtctttga cctctgtggg ggtctcgacg gcttcttcgc ggtcaagcac      480

gcgcgctaca ccctaaagcc actgctgcgc ggaccctggg cggaggaaga aaaggggcgc      540

gtgtacgggg atgggtccgc acggatcctg cacgtctaca cccgcgaggg cttcagcttc      600

gaggccctgc cgccgcgcgc cagctgcgaa acccccgcgt ccacaccgga ggcccacgag      660

catgctccgg cgcacagcaa cccgagcgga cgcgcagcac tggcctcgca gctcttggac      720

cagtccgctc tctcgcccgc tgggggctca ggaccgcaga cgtggtggcg gcggcggcgc      780

cgctccatct cccgggcccg ccaggtggag ctgcttctgg tggctgacgc gtccatggcg      840

cggttgtatg gccggggcct gcagcattac ctgctgaccc tggcctccat cgccaatagg      900

ctgtacagcc atgctagcat cgagaaccac atccgcctgg ccgtggtgaa ggtggtggtg      960

ctaggcgaca aggacaagag cctggaagtg agcaagaacg ctgccaccac actcaagaac     1020

ttttgcaagt ggcagcacca acacaaccag ctgggagatg accatgagga gcactacgat     1080

gcagctatcc tgtttactcg ggaggattta tgtgggcatc attcatgtga caccctggga     1140

atggcagacg ttgggaccat atgttctcca gagcgcagct gtgctgtgat tgaagacgat     1200

ggcctccacg cagccttcac tgtggctcac gaaatcggac atttacttgg cctctcccat     1260

gacgattcca aattctgtga agagaccttt ggttccacag aagataagcg cttaatgtct     1320

tccatcctta ccagcattga tgcatctaag ccctggtcca aatgcacttc agccaccatc     1380

acagaattcc tggatgatgg ccatggtaac tgtttgctgg acctaccacg aaagcagatc     1440

ctgggccccg aagaactccc aggacagacc tacgatgcca cccagcagtg caacctgaca     1500

ttcgggcctg agtactccgt gtgtcccggc atggatgtct gtgctcgcct gtggtgtgct     1560

gtggtacgcc agggccagat ggtctgtctg accaagaagc tgcctgcggt ggaagggacg     1620

ccttgtggaa aggggagaat ctgcctgcag ggcaaatgtg tggacaaaac caagaaaaaa     1680

tattattcaa cgtcaagcca tggcaactgg ggatcttggg gatcctgggg ccagtgttct     1740

cgctcatgtg gaggaggagt gcagtttgcc tatcgtcact gtaataaccc tgctcccaga     1800

aacaacggac gctactgcac agggaagagg gccatctacc gctcctgcag tctcatgccc     1860

tgcccaccca atggtaaatc atttcgtcat gaacagtgtg aggccaaaaa tggctatcag     1920

tctgatgcaa aaggagtcaa aacttttgtg gaatgggttc ccaaatatgc aggtgtcctg     1980

ccagcggatg tgtgcaagct gacctgcaga gccaagggca ctggctacta tgtggtattt     2040

tctccaaagg tgaccgatgg cactgaatgt aggccgtaca gtaattccgt ctgcgtccgg     2100

gggaagtgtg tgagaactgg ctgtgacggc atcattggct caaagctgca gtatgacaag     2160

tgcggagtat gtggaggaga caactccagc tgtacaaaga ttgttggaac ctttaataag     2220

aaaagtaagg gttacactga cgtggtgagg attcctgaag gggcaaccca cataaaagtt     2280

cgacagttca aagccaaaga ccagactaga ttcactgcct atttagccct gaaaaagaaa     2340

aacggtgagt accttatcaa tggaaagtac atgatctcca cttcagagac tatcattgac     2400

atcaatggaa cagtcatgaa ctatagcggt tggagccaca gggatgactt cctgcatggc     2460

atgggctact ctgccacgaa ggaaattcta atagtgcaga ttcttgcaac agaccccact     2520

aaaccattag atgtccgtta tagctttttt gttcccaaga agtccactcc aaaagtaaac     2580

tctgtcacta gtcatggcag caataaagtg ggatcacaca cttcgcagcc gcagtgggtc     2640

acgggcccat ggctcgcctg ctctaggacc tgtgacacag gttggcacac cagaacggtg     2700

cagtgccagg atggaaaccg gaagttagca aaaggatgtc ctctctccca aaggccttct     2760

gcgtttaagc aatgcttgtt gaagaaatgt tag                                  2793


<210>  134
<211>  2514
<212>  DNA
<213>  Homo sapiens

<400>  134
atgtcccaga caggctcgca tcccgggagg ggcttggcag ggcgctggct gtggggagcc       60

caaccctgcc tcctgctccc cattgtgccg ctctcctggc tggtgtggct gcttctgcta      120

ctgctggcct ctctcctgcc ctcagcccgg ctggccagcc ccctcccccg ggaggaggag      180

atcgtgtttc cagagaagct caacggcagc gtcctgcctg gctcgggcgc ccctgccagg      240

ctgttgtgcc gcttgcaggc ctttggggag acgctgctac tagagctgga gcaggactcc      300

ggtgtgcagg tcgaggggct gacagtgcag tacctgggcc aggcgcctga gctgctgggt      360

ggagcagagc ctggcaccta cctgactggc accatcaatg gagatccgga gtcggtggca      420

tctctgcact gggatggggg agccctgtta ggcgtgttac aatatcgggg ggctgaactc      480

cacctccagc ccctggaggg aggcacccct aactctgctg ggggacctgg ggctcacatc      540

ctacgccgga agagtcctgc cagcggtcaa ggtcccatgt gcaacgtcaa ggctcctctt      600

ggaagcccca gccccagacc ccgaagagcc aagcgctttg cttcactgag tagatttgtg      660

gagacactgg tggtggcaga tgacaagatg gccgcattcc acggtgcggg gctaaagcgc      720

tacctgctaa cagtgatggc agcagcagcc aaggccttca agcacccaag catccgcaat      780

cctgtcagct tggtggtgac tcggctagtg atcctggggt caggcgagga ggggccccaa      840

gtggggccca gtgctgccca gaccctgcgc agcttctgtg cctggcagcg gggcctcaac      900

acccctgagg actcggaccc tgaccacttt gacacagcca ttctgtttac ccgtcaggac      960

ctgtgtggag tctccacttg cgacacgctg ggtatggctg atgtgggcac cgtctgtgac     1020

ccggctcgga gctgtgccat tgtggaggat gatgggctcc agtcagcctt cactgctgct     1080

catgaactgg gtcatgtctt caacatgctc catgacaact ccaagccatg catcagtttg     1140

aatgggcctt tgagcacctc tcgccatgtc atggcccctg tgatggctca tgtggatcct     1200

gaggagccct ggtccccctg cagtgcccgc ttcatcactg acttcctgga caatggctat     1260

gggcactgtc tcttagacaa accagaggct ccattgcatc tgcctgtgac tttccctggc     1320

aaggactatg atgctgaccg ccagtgccag ctgaccttcg ggcccgactc acgccattgt     1380

ccacagctgc cgccgccctg tgctgccctc tggtgctctg gccacctcaa tggccatgcc     1440

atgtgccaga ccaaacactc gccctgggcc gatggcacac cctgcgggcc cgcacaggcc     1500

tgcatgggtg gtcgctgcct ccacatggac cagctccagg acttcaatat tccacaggct     1560

ggtggctggg gtccttgggg accatggggt gactgctctc ggacctgtgg gggtggtgtc     1620

cagttctcct cccgagactg cacgaggcct gtcccccgga atggtggcaa gtactgtgag     1680

ggccgccgta cccgcttccg ctcctgcaac actgaggact gcccaactgg ctcagccctg     1740

accttccgcg aggagcagtg tgctgcctac aaccaccgca ccgacctctt caagagcttc     1800

ccagggccca tggactgggt tcctcgctac acaggcgtgg ccccccagga ccagtgcaaa     1860

ctcacctgcc aggcccaggc actgggctac tactatgtgc tggagccacg ggtggtagat     1920

gggaccccct gttccccgga cagctcctcg gtctgtgtcc agggccgatg catccatgct     1980

ggctgtgatc gcatcattgg ctccaagaag aagtttgaca agtgcatggt gtgcggaggg     2040

gacggttctg gttgcagcaa gcagtcaggc tccttcagga aattcaggta cggatacaac     2100

aatgtggtca ctatccccgc gggggccacc cacattcttg tccggcagca gggaaaccct     2160

ggccaccgga gcatctactt ggccctgaag ctgccagatg gctcctatgc cctcaatggt     2220

gaatacacgc tgatgccctc ccccacagat gtggtactgc ctggggcagt cagcttgcgc     2280

tacagcgggg ccactgcagc ctcagagaca ctgtcaggcc atgggccact ggcccagcct     2340

ttgacactgc aagtcctagt ggctggcaac ccccaggaca cacgcctccg atacagcttc     2400

ttcgtgcccc ggccgacccc ttcaacgcca cgccccactc cccaggactg gctgcaccga     2460

agagcacaga ttctggagat ccttcggcgg cgcccctggg cgggcaggaa ataa           2514


<210>  135
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asp Leu Leu His Lys Asp Gly Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ser Gly Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Thr Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Thr 
145                 150                 155                 160 


Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys Val Asp Trp 
                165                 170                 175     


Tyr Gln Gln Thr Pro Gly Lys Gly Pro Arg Phe Val Met Arg Val Gly 
            180                 185                 190         


Thr Gly Gly Thr Val Gly Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe 
        195                 200                 205             


Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Ile Ile Lys Asn Ile 
    210                 215                 220                 


Gln Glu Glu Asp Glu Thr Asp Tyr His Cys Gly Ala Asp His Gly Ser 
225                 230                 235                 240 


Gly Ser Asn Phe Val Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val 
                245                 250                 255     


Leu 
    


<210>  136
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Thr Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Phe Asp Gly Thr Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Ser Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Ser Gly Thr Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Pro Ser Gln Gly Ile Gly Lys Tyr Ser Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Glu Leu Pro Ile Tyr Leu Ala Ser Thr Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Asp Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Leu Gln Arg Asn Thr Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  137
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ser Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Val Ser Gly Tyr Arg Leu Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Gly Phe Asp Leu Glu Asn Gly Val Thr Lys Ala Ala Pro Arg Phe 
    50                  55                  60                  


Arg Gly Arg Phe Thr Met Thr Glu Asp Thr Ser Thr Asp Ser Val Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Pro Gly Tyr Gly Ala Leu Val Thr Ser Phe Thr Ser Trp 
            100                 105                 110         


Gly Leu Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Gly Thr Ser Tyr 
    130                 135                 140                 


Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Ser Ile Thr Cys Ser Gly Asp Lys Leu Glu Asp Lys Tyr Ala Cys Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr His Asp 
            180                 185                 190         


Tyr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Gly Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Ser Asp Asp Gln Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  138
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  138

Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
1               5                   10                  15      


Ser Ser Gly Thr 
            20  


<210>  139
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  139
ttatcctcga gcggtaccca ggtgcagctg caggagtcsg                             40


<210>  140
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  140
ttatcctcga gcggtaccca ggtacagctg cagcagtca                              39


<210>  141
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  141
ttatcctcga gcggtaccca ggtgcagcta cagcagtggg                             40


<210>  142
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  142
ttatcctcga gcggtaccga ggtgcagctg ktggagwcy                              39


<210>  143
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  143
ttatcctcga gcggtaccca ggtccagctk gtrcagtctg g                           41


<210>  144
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  144
ttatcctcga gcggtaccca grtcaccttg aaggagtctg                             40


<210>  145
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  145
ttatcctcga gcggtaccca ggtgcagctg gtgsartctg g                           41


<210>  146
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  146
gattggtttg ccgctagctg aggagacrgt gaccagggtg                             40


<210>  147
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  147
gattggtttg ccgctagctg aggagacggt gaccagggtt                             40


<210>  148
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  148
gattggtttg ccgctagctg aagagacggt gaccattgt                              39


<210>  149
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  149
gattggtttg ccgctagctg aggagacggt gaccgtggtc c                           41


<210>  150
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  150
agcaagcggc gcgcatgccg acatccrgdt gacccagtct cc                          42


<210>  151
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  151
agcaagcggc gcgcatgccg aaattgtrwt gacrcagtct cc                          42


<210>  152
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  152
agcaagcggc gcgcatgccg atattgtgmt gacbcagwct cc                          42


<210>  153
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  153
agcaagcggc gcgcatgccg aaacgacact cacgcagtct c                           41


<210>  154
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  154
gaagttatgg tcgaccctcc ggatttgatt tccaccttgg tcc                         43


<210>  155
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  155
gaagttatgg tcgaccctcc ggatttgatc tccascttgg tcc                         43


<210>  156
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  156
gaagttatgg tcgaccctcc ggatttgata tccactttgg tcc                         43


<210>  157
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  157
gaagttatgg tcgaccctcc ggatttaatc tccagtcgtg tcc                         43


<210>  158
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  158
agcaagcggc gcgcatgccc agtctgtsbt gacgcagccg cc                          42


<210>  159
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  159
agcaagcggc gcgcatgcct cctatgwgct gacwcagcca c                           41


<210>  160
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  160
agcaagcggc gcgcatgcct cctatgagct gayrcagcya cc                          42


<210>  161
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  161
agcaagcggc gcgcatgccc agcctgtgct gactcaryc                              39


<210>  162
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  162
agcaagcggc gcgcatgccc agdctgtggt gacycaggag cc                          42


<210>  163
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  163
agcaagcggc gcgcatgccc agccwgkgct gactcagccm cc                          42


<210>  164
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  164
agcaagcggc gcgcatgcct cctctgagct gastcaggas cc                          42


<210>  165
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  165
agcaagcggc gcgcatgccc agtctgyyct gaytcagcct                             40


<210>  166
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  166
agcaagcggc gcgcatgcca attttatgct gactcagccc c                           41


<210>  167
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  167
gaagttatgg tcgaccctcc ggataggacg gtsascttgg tcc                         43


<210>  168
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  168
gaagttatgg tcgaccctcc ggagaggacg gtcagctggg tgc                         43


<210>  169
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  169
cgctggattg ttattactcg cagcaagcgg cgcgcatgcc                             40


<210>  170
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  170
accgctcgag ccttcaccgg aacctggttt cccagaaccg ctggtcgacc ctcc             54


<210>  171
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  171
ggagggtcga ccagcggttc tgggaaacca ggttccggtg aaggctcgag cggta            55


<210>  172
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  172
ccaggcccag cagtgggttt gggattggtt tgccgcta                               38


<210>  173
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  173
tacctattgc ctacggcagc cgctggattg ttattactc                              39


<210>  174
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  174
tggtgatggt gagtactatc caggcccagc agtgggtttg                             40


<210>  175
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  175
agcaagcggc gcgcatgccc aggtgcagct ggtgcagtct gg                          42


<210>  176
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  176
agcaagcggc gcgcatgccc aggtcaactt aagggagtct gg                          42


<210>  177
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  177
agcaagcggc gcgcatgccg aggtgcagct ggtggagtct gg                          42


<210>  178
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  178
agcaagcggc gcgcatgccc aggtgcagct gcaggagtcg gg                          42


<210>  179
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  179
agcaagcggc gcgcatgccg aggtgcagct gttgcagtct gc                          42


<210>  180
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  180
agcaagcggc gcgcatgccc aggtacagct gcagcagtca gg                          42


<210>  181
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  181
gaagttatgg tcgaccctcc ggatgaggag acggtgacca gggtgcc                     47


<210>  182
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  182
gaagttatgg tcgaccctcc ggatgaagag acggtgacca ttgtccc                     47


<210>  183
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  183
gaagttatgg tcgaccctcc ggatgaggag acggtgacca gggttcc                     47


<210>  184
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  184
gaagttatgg tcgaccctcc ggatgaggag acggtgaccg tggtccc                     47


<210>  185
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  185
ttatcctcga gcggtaccga catccagatg acccagtctc c                           41


<210>  186
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  186
ttatcctcga gcggtaccga tgttgtgatg actcagtctc c                           41


<210>  187
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  187
ttatcctcga gcggtaccga aattgtgttg acgcagtctc c                           41


<210>  188
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  188
ttatcctcga gcggtaccga catcgtgatg acccagtctc c                           41


<210>  189
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  189
ttatcctcga gcggtaccga aacgacactc acgcagtctc c                           41


<210>  190
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  190
ttatcctcga gcggtaccga aattgtgctg actcagtctc c                           41


<210>  191
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  191
gattggtttg ccgctagcac gtttgatttc caccttggtc cc                          42


<210>  192
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  192
gattggtttg ccgctagcac gtttgatctc cagcttggtc cc                          42


<210>  193
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  193
gattggtttg ccgctagcac gtttgatatc cactttggtc cc                          42


<210>  194
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  194
gattggtttg ccgctagcac gtttgatctc caccttggtc cc                          42


<210>  195
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  195
gattggtttg ccgctagcac gtttaatctc cagtcgtgtc cc                          42


<210>  196
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  196
ttatcctcga gcggtaccca gtctgtgttg acgcagccgc c                           41


<210>  197
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  197
ttatcctcga gcggtaccca gtctgccctg actcagcctg c                           41


<210>  198
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  198
ttatcctcga gcggtacctc ctatgtgctg actcagccac c                           41


<210>  199
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  199
ttatcctcga gcggtacctc ttctgagctg actcaggacc c                           41


<210>  200
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  200
ttatcctcga gcggtaccca cgttatactg actcaaccgc c                           41


<210>  201
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  201
ttatcctcga gcggtaccca ggctgtgctc actcagccgt c                           41


<210>  202
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  202
gattggtttg ccgctagcac ctaggacggt gaccttggtc cc                          42


<210>  203
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  203
gattggtttg ccgctagcac ctaggacggt cagcttggtc cc                          42


<210>  204
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  204
gattggtttg ccgctagcac ctaaaacggt gagctgggtc cc                          42


<210>  205
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  205
cgctggattg ttattactcg cagcaagcgg cgcgcatgcc                             40


<210>  206
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  206
accgctcgag ccttcaccgg aacctggttt cccagaaccg ctggtcgacc ctcc             54


<210>  207
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  207
ggagggtcga ccagcggttc tgggaaacca ggttccggtg aaggctcgag cggta            55


<210>  208
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  208
ccaggcccag cagtgggttt gggattggtt tgccgcta                               38


<210>  209
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  209
tacctattgc ctacggcagc cgctggattg ttattactc                              39


<210>  210
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  210
tggtgatggt gagtactatc caggcccagc agtgggtttg                             40


<210>  211
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  211
tggctggaat tcacaaagat tgttgga                                           27


<210>  212
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  212
gtcgacggat ccttaagtgt gtgatcccac                                        30


<210>  213
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  213
aattcaacgc tgccaccaca ctcaagaact tttgcaagtg gcagcaccaa cacaactaac       60

tgca                                                                    64


<210>  214
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  214
gttagttgtg ttggtgctgc cacttgcaaa agttcttgag tgtggtggca gcgttg           56


<210>  215
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  215
atccatggtc acaaagattg ttggaacc                                          28


<210>  216
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  216
atctcgagtt aagtgtgtga tcccacttta ttg                                    33


