                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum				     
       Ruprecht-Karls-Universitt Heidelberg
       The Hebrew University of Jerusalem
       Hadassah Medical Organization

 
<120>  Inhibitors of Receptor for Advanced Glycation-End products (RAGE)
       for use in treating and/or preventing inflammation- and/or 
       damage-induced cancer

<130>  DK10784PC

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1556
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgaaagatg ggggctggag agagggtgca ggccccacct agggcggagg ccacagcagg       60

gagaggggca gacagagcca ggaccctgga aggaagcagg atggcagccg gaacagcagt      120

tggagcctgg gtgctggtcc tcagtctgtg gggggcagta gtaggtgctc aaaacatcac      180

agcccggatt ggcgagccac tggtgctgaa gtgtaagggg gcccccaaga aaccacccca      240

gcggctggaa tggaaactga acacaggccg gacagaagct tggaaggtcc tgtctcccca      300

gggaggaggc ccctgggaca gtgtggctcg tgtccttccc aacggctccc tcttccttcc      360

ggctgtcggg atccaggatg aggggatttt ccggtgccag gcaatgaaca ggaatggaaa      420

ggagaccaag tccaactacc gagtccgtgt ctaccagatt cctgggaagc cagaaattgt      480

agattctgcc tctgaactca cggctggtgt tcccaataag gtagtggaag aaagcaggag      540

aagtagaaaa cggccctgtg aacaggaggt ggggacatgt gtgtcagagg gaagctaccc      600

tgcagggact cttagctggc acttggatgg gaagcccctg gtgcctaatg agaagggagt      660

atctgtgaag gaacagacca ggagacaccc tgagacaggg ctcttcacac tgcagtcgga      720

gctaatggtg accccagccc ggggaggaga tccccgtccc accttctcct gtagcttcag      780

cccaggcctt ccccgacacc gggccttgcg cacagccccc atccagcccc gtgtctggga      840

gcctgtgcct ctggaggagg tccaattggt ggtggagcca gaaggtggag cagtagctcc      900

tggtggaacc gtaaccctga cctgtgaagt ccctgcccag ccctctcctc aaatccactg      960

gatgaaggat ggtgtgccct tgccccttcc ccccagccct gtgctgatcc tccctgagat     1020

agggcctcag gaccagggaa cctacagctg tgtggccacc cattccagcc acgggcccca     1080

ggaaagccgt gctgtcagca tcagcatcat cgaaccaggc gaggaggggc caactgcagg     1140

ctctgtggga ggatcagggc tgggaactct agccctggcc ctggggatcc tgggaggcct     1200

ggggacagcc gccctgctca ttggggtcat cttgtggcaa aggcggcaac gccgaggaga     1260

ggagaggaag gccccagaaa accaggagga agaggaggag cgtgcagaac tgaatcagtc     1320

ggaggaacct gaggcaggcg agagtagtac tggagggcct tgaggggccc acagacagat     1380

cccatccatc agctcccttt tctttttccc ttgaactgtt ctggcctcag accaactctc     1440

tcctgtataa tctctctcct gtataacccc accttgccaa gctttcttct acaaccagag     1500

ccccccacaa tgatgattaa acacctgaca catcttgcaa aaaaaaaaaa aaaaaa         1556


<210>  2
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Val Glu Glu 
    130                 135                 140                 


Ser Arg Arg Ser Arg Lys Arg Pro Cys Glu Gln Glu Val Gly Thr Cys 
145                 150                 155                 160 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
                165                 170                 175     


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
            180                 185                 190         


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
        195                 200                 205             


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
    210                 215                 220                 


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
225                 230                 235                 240 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
                245                 250                 255     


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
            260                 265                 270         


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
        275                 280                 285             


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
    290                 295                 300                 


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
305                 310                 315                 320 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
                325                 330                 335     


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
            340                 345                 350         


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
        355                 360                 365             


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
    370                 375                 380                 


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
385                 390                 395                 400 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
                405                 410                 415     


Thr Gly Gly Pro 
            420 


<210>  3
<211>  3355
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgaaagatg ggggctggag agagggtgca ggccccacct agggcggagg ccacagcagg       60

gagaggggca gacagagcca ggaccctgga aggaagcagg atggctgccg gaacagcagt      120

tggagcctgg gtgctggtcc tcagtctgtg gggtgagcca ctccctcaac cccactgacc      180

ctccctgcag aaagcacttt aaccccacac cccagtcgtc ctagaacttt tcccagaacc      240

cgaggaagtg cctttcaagg tccctcaccc accctgtcca aattttgtta gccctcattc      300

ccttcctacc cctctaccat ggtgctatct cccaggggca gtagtaggtg ctcaaaacat      360

cacagcccgg attggcgagc cactggtgct gaagtgtaag ggggccccca agaaaccacc      420

ccagcggctg gaatggaaac tggtaagcgg ggctcctgtt gcagcctccc aacttccagg      480

gagaccagca atgatttgga tccccgtcac tctgcctcac agtcctttcc caaaggcctt      540

gcactgttta ggccctgctt ctctgcttct agaacacagg ccggacagaa gcttggaagg      600

tcctgtctcc ccagggagga ggcccctggg acagtgtggc tcgtgtcctt cccaacggct      660

ccctcttcct tccggctgtc gggatccagg atgaggggat tttccggtgc caggcaatga      720

acaggaatgg aaaggagacc aagtccaact accgagtccg tgtctaccgt aagaattcca      780

gggtcttctc caaggcctcc ctcttaccta agaaaaagcc ttcaacccca gccttggccc      840

atgagggcct ctgacttcca ctggcctcat ttccacacac agagtttgag aaccttcaca      900

attacagcct ctgactggat ttttcctcct tcagagattc ctgggaagcc agaaattgta      960

gattctgcct ctgaactcac ggctggtgtt cccaataagg tagtggaaga aagcaggaga     1020

agtagaaaac ggccctgtga acaggaggcg agtgtgtgtg ggtgtgggtg tgtggcatct     1080

ctcattttca aaggattctg aggtcaccac tctttcccca ggtggggaca tgtgtgtcag     1140

agggaagcta ccctgcaggg actcttagct ggcacttgga tgggaagccc ctggtgccta     1200

atgagaaggg tgagtcctaa ggtgcccccc aagctgcctt ctccctgatc tcactcccac     1260

acccaccctg ggataatttg tcttatcctc ccatcatagg agtatctgtg aaggaacaga     1320

ccaggagaca ccctgagaca gggctcttca cactgcagtc ggagctaatg gtgaccccag     1380

cccggggagg agatccccgt cccaccttct cctgtagctt cagcccaggc cttccccgac     1440

accgggcctt gcgcacagcc cccatccagc cccgtgtctg gggtgagcat aggtggggag     1500

ggccccaagc tcacgtgagc acgttctgga agtctgaccc ttagggaaag agggagtcaa     1560

gcccatggcc actgggatca ctcacaagtg taactctcca cctcaaaacc cttccaactc     1620

ccagagcctg tgcctctgga ggaggtccaa ttggtggtgg agccagaagg tggagcagta     1680

gctcctggtg gaaccgtaac cctgacctgt gaagtccctg cccagccctc tcctcaaatc     1740

cactggatga aggatgtgag tgacctggag agaggggctg ggaggtaggg tgaaccataa     1800

ctagcaacag ggagggcaga gggctaacga gggaaaggca ggctaggagc tgaggaggaa     1860

gagagggtat ctgaagatat ggagacaaaa agacaagggt tttgaaatag tctcctctcc     1920

ccttccccca ccagggtgtg cccttgcccc ttccccccag ccctgtgctg atcctccctg     1980

agatagggcc tcaggaccag ggaacctaca gctgtgtggc cacccattcc agccacgggc     2040

cccaggaaag ccgtgctgtc agcatcagca tcatcggtga gacctctccc caagccctac     2100

agaccctggg actagggtgc aggacagcac aggctctaat ttcctgcccc attctggcct     2160

tatccctaac agccacccca cctctccctc catgcaccca cacccaagcc tcccctgccc     2220

cacccaaatt ctgccaagag agcagccaag cctctccctt cttccctctg agctaaaaaa     2280

aggaacagac ggctgggcgc ggtggctcac gcctgtaatc ccaacacttt gggaggctga     2340

ggcgggcaga tcacctgagg tagggagttc gagaccagcc tgaccaacat ggagaaaccc     2400

catttctact aaaaatacaa aattagccag gcatggtggc acatgcctgt aatcccagct     2460

acctgggagg ccagctactt gagaggctga ggcaggagaa ttgcttgaac ccaggaggca     2520

tagattgcga tgagccaaga tcgcaccatt gcatgccagc ctgggcaaca aaagtgaaac     2580

tccatctcaa aaaaaaaaag aaagggaaag actccactgg ggctcccact aaataaccct     2640

ctctcaaccc gaagtcttcc tttctgactg gatccaactt tgtcttccag aaccaggcga     2700

ggaggggcca actgcaggtg aggggtttga taaagtcagg gaagcagaag atagccccca     2760

acacatgtga ctggggggat ggtcaacaag aaaggaatgg tgagtggtgg tggctgtgct     2820

ctcaattttc cctgtctccg tacaggctct gtgggaggat cagggctggg aactctagcc     2880

ctggccctgg ggatcctggg aggcctgggg acagccgccc tgctcattgg ggtcatcttg     2940

tggcaaaggc ggcaacgccg aggagaggag aggtgagtgg agaaagccag acccctcaga     3000

cctagggctt ccaggcagca agcgaagagg ggtcgggggg tggaacgaca acgtgccgca     3060

ttccccccaa tctttctcct caggaaggcc ccagaaaacc aggaggaaga ggaggagcgt     3120

gcagaactga atcagtcgga ggaacctgag gcaggcgaga gtagtactgg agggccttga     3180

ggggcccaca gacagatccc atccatcagc tcccttttct ttttcccttg aactgttctg     3240

gcctcagacc aactctctcc tgtataatct ctctcctgta taaccccacc ttgccaagct     3300

ttcttctaca accagagccc cccacaatga tgattaaaca cctgacacat cttgc          3355


