
                                SEQUENCE LISTING

<110> BUCK INSTITUTE FOR RESEARCH ON AGING
      DE KEIZER, Peterus Leonardus Josephus
      CAMPISI, Judith
      LABERGE, Remi-Martin
      

<120> TARGETING SENESCENT CELLS AND CANCER
  CELLS BY INTERFERENCE WITH JNK AND/OR FOXO4
  

<130> 701982000440

<140> PCT/US2013/035020   
<141> 2013-04-02  

<150> US 61/619,325       
<151> 2012-04-02  

<150> US 13/830,846       
<151> 2013-03-14  

<160> 68

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile
 1               5                  10                  15      
Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr
            20                  25                  30          
Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro
        35                  40                  45              
Glu Val Glu Pro Asp Leu Gly Glu Lys Val His Thr Glu Gly Arg Ser
    50                  55                  60                  
Glu Pro Ile Leu Leu Pro Ser Arg Leu Pro Glu Pro Ala Gly Gly Pro
65                  70                  75                  80  
Gln Pro Gly Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser
                85                  90                  95      
Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln
            100                 105                 110         
Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr
        115                 120                 125             
Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser
    130                 135                 140                 
Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu
145                 150                 155                 160 
His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser
                165                 170                 175     
Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg
            180                 185                 190         
Arg Arg Ala Ala Ser Met Asp Ser Ser Ser Lys Leu Leu Arg Gly Arg
        195                 200                 205             
Ser Lys Ala Pro Lys Lys Lys Pro Ser Val Leu Pro Ala Pro Pro Glu
    210                 215                 220                 
Gly Ala Thr Pro Thr Ser Pro Val Gly His Phe Ala Lys Trp Ser Gly
225                 230                 235                 240 
Ser Pro Cys Ser Arg Asn Arg Glu Glu Ala Asp Met Trp Thr Thr Phe
                245                 250                 255     
Arg Pro Arg Ser Ser Ser Asn Ala Ser Ser Val Ser Thr Arg Leu Ser
            260                 265                 270         
Pro Leu Arg Pro Glu Ser Glu Val Leu Ala Glu Glu Ile Pro Ala Ser
        275                 280                 285             
Val Ser Ser Tyr Ala Gly Gly Val Pro Pro Thr Leu Asn Glu Gly Leu
    290                 295                 300                 
Glu Leu Leu Asp Gly Leu Asn Leu Thr Ser Ser His Ser Leu Leu Ser
305                 310                 315                 320 
Arg Ser Gly Leu Ser Gly Phe Ser Leu Gln His Pro Gly Val Thr Gly
                325                 330                 335     
Pro Leu His Thr Tyr Ser Ser Ser Leu Phe Ser Pro Ala Glu Gly Pro
            340                 345                 350         
Leu Ser Ala Gly Glu Gly Cys Phe Ser Ser Ser Gln Ala Leu Glu Ala
        355                 360                 365             
Leu Leu Thr Ser Asp Thr Pro Pro Pro Pro Ala Asp Val Leu Met Thr
    370                 375                 380                 
Gln Val Asp Pro Ile Leu Ser Gln Ala Pro Thr Leu Leu Leu Leu Gly
385                 390                 395                 400 
Gly Leu Pro Ser Ser Ser Lys Leu Ala Thr Gly Val Gly Leu Cys Pro
                405                 410                 415     
Lys Pro Leu Glu Ala Pro Gly Pro Ser Ser Leu Val Pro Thr Leu Ser
            420                 425                 430         
Met Ile Ala Pro Pro Pro Val Met Ala Ser Ala Pro Ile Pro Lys Ala
        435                 440                 445             
Leu Gly Thr Pro Val Leu Thr Pro Pro Thr Glu Ala Ala Ser Gln Asp
    450                 455                 460                 
Arg Met Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu
465                 470                 475                 480 
Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly
                485                 490                 495     
Leu Asp Phe Asn Phe Glu Pro Asp Pro
            500                 505 


<210> 2
<211> 119
<212> PRT
<213> Homo sapiens

<400> 2
Ile Leu Gly Ala Val Thr Gly Pro Arg Lys Gly Gly Ser Arg Arg Asn
 1               5                  10                  15      
Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser Gln Ala Ile Glu
            20                  25                  30          
Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln Ile Tyr Glu Trp Met
        35                  40                  45              
Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser
    50                  55                  60                  
Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys
65                  70                  75                  80  
Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys Ser Ser Trp Trp Met
                85                  90                  95      
Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala
            100                 105                 110         
Ala Ser Met Asp Ser Ser Ser
        115                 


<210> 3
<211> 39
<212> PRT
<213> Homo sapiens

<400> 3
Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp
 1               5                  10                  15      
Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp
            20                  25                  30          
Phe Asn Phe Glu Pro Asp Pro
        35                  


<210> 4
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Lys Arg Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln
 1               5                  10                  15      
Asp Thr
        


<210> 5
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
His Lys His Arg Pro Thr Thr Leu Arg Leu Thr Thr Leu Gly Ala Gln
 1               5                  10                  15      
Asp Ser
        


<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu Phe
 1               5                  10      


<210> 7
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Gly Pro Gly Thr Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg Pro Thr
 1               5                  10                  15      
Thr Leu Asn Leu Phe
            20      


<210> 8
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 1
<223> Xaa = D-Asp

<221> VARIANT        
<222> 2, 7, 11
<223> Xaa = D-Gln

<221> VARIANT        
<222> 3
<223> Xaa = D-Ser

<221> VARIANT        
<222> 4, 16, 19
<223> Xaa = D-Arg

<221> VARIANT        
<222> 5, 8, 15, 18
<223> Xaa = D-Pro

<221> VARIANT        
<222> 6
<223> Xaa = D-Val 

<221> VARIANT        
<222> 9
<223> Xaa = D-Phe

<221> VARIANT        
<222> 10, 12
<223> Xaa = D-Leu

<221> VARIANT        
<222> 13, 14
<223> Xaa = D-Thr 

<221> VARIANT        
<222> 17
<223> Xaa = D-Lys 

<400> 8
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa
            


<210> 9
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 1
<223> Xaa = D-Asp

<221> VARIANT        
<222> 2, 7, 11, 25
<223> Xaa = D-Gln

<221> VARIANT        
<222> 3
<223> Xaa = D-Ser

<221> VARIANT        
<222> 4, 16, 19, 22, 23, 24, 26, 27, 30
<223> Xaa = D-Arg

<221> VARIANT        
<222> 5, 8, 15, 18, 20, 21
<223> Xaa = D-Pro

<221> VARIANT        
<222> 6
<223> Xaa = D-Val

<221> VARIANT        
<222> 9
<223> Xaa = D-Phe

<221> VARIANT        
<222> 10, 12
<223> Xaa = D-Leu

<221> VARIANT        
<222> 13, 14
<223> Xaa = D-Thr

<221> VARIANT        
<222> 17, 28, 29
<223> Xaa = D-Lys 

<221> VARIANT        
<222> 31
<223> Xaa = D-Gly

<400> 9
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            20                  25                  30      


<210> 10
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 1
<223> Xaa = D-Asp

<221> VARIANT        
<222> 2, 7, 11, 25
<223> Xaa = D-Gln

<221> VARIANT        
<222> 3
<223> Xaa = D-Ser

<221> VARIANT        
<222> 4, 16, 19, 22, 23, 24, 26, 27, 30
<223> Xaa = D-Arg

<221> VARIANT        
<222> 5, 8, 15, 18, 20, 21
<223> Xaa = D-Pro

<221> VARIANT        
<222> 6
<223> Xaa = D-Val

<221> VARIANT        
<222> 9
<223> Xaa = D-Phe

<221> VARIANT        
<222> 10, 12
<223> Xaa = D-Leu

<221> VARIANT        
<222> 13, 14
<223> Xaa = D-Thr

<221> VARIANT        
<222> 17, 28, 29
<223> Xaa = D-Lys 

<400> 10
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly
            20                  25                  30      


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10  


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro
 1               5                  10          


<210> 13
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val
            20                  25          


<210> 14
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu
 1               5                  10                  15      
Leu Trp Arg Ala
            20  


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Arg Arg Arg Arg Arg Arg Arg Arg
 1               5              


<210> 17
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Lys Arg Pro Thr
 1               5                  10                  15      
Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr
            20                  25                  30  


<210> 18
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro His Lys His Arg
 1               5                  10                  15      
Pro Thr Thr Leu Arg Leu Thr Thr Leu Gly Ala Gln Asp Ser
            20                  25                  30  


<210> 19
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Arg Pro Lys Arg
 1               5                  10                  15      
Pro Thr Thr Leu Asn Leu Phe
            20              


<210> 20
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gly Pro Gly Thr
 1               5                  10                  15      
Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg Pro Thr Thr Leu Asn Leu
            20                  25                  30          
Phe
    


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser
 1               5                  10                  15      


<210> 22
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Pro Arg Lys Gly Gly Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr
 1               5                  10                  15      
Ala Glu Leu Ile Ser Gln Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu
            20                  25                  30          
Thr Leu
        


<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Leu Glu Cys Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly
 1               5                  10                  15      
Glu Gly Leu Asp Phe
            20      


<210> 24
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Pro Gln Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp
 1               5                  10                  15      
Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp
            20                  25                  30          
Phe
    


<210> 25
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Ser Arg Arg Asn
 1               5                  10                  15      
Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile Ser
            20                  25              


<210> 26
<211> 46
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Pro Arg Lys Gly
 1               5                  10                  15      
Gly Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile
            20                  25                  30          
Ser Gln Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu
        35                  40                  45      


<210> 27
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Leu Glu Cys Asp
 1               5                  10                  15      
Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp
            20                  25                  30          
Phe
    


<210> 28
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Pro Gln Asp Leu
 1               5                  10                  15      
Asp Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp Met Asp Asn Ile
            20                  25                  30          
Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp Phe
        35                  40                  45  


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Ala Trp Gly Asn
 1              


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Asn Ala Trp Gly Asn
 1               5  


<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Arg Asn Ala Trp Gly Asn
 1               5      


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Arg Arg Asn Ala Trp Gly Asn
 1               5          


<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Arg Arg Asn Ala Trp Gly Asn Gln
 1               5              


<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser
 1               5                  10  


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr
 1               5                  10  


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu
 1               5                  10              


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu
 1               5                  10                  


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile
 1               5                  10                  15  


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Asp Leu Met Asp
 1              


<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Ser Asp Leu Met Asp Glu
 1               5      


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Asp Asn Ile Ile Ser Asp
 1               5      


<210> 42
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Ile Ile Ser Asp Leu Met Asp Glu Gly Glu
 1               5                  10  


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Asp Asn Ile Ile Ser Asp Leu Met Asp Glu
 1               5                  10  


<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Asp Met Asp Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu
 1               5                  10                  


<210> 45
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Lys Lys Arg Arg
 1              


<210> 46
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Arg Lys Lys Arg Arg
 1               5  


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Arg Lys Lys Arg Arg Gln
 1               5      


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Arg Lys Lys Arg Arg Gln Arg Arg
 1               5              


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
ccagcttcag tcagcagtta t                                           21

<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
cgtccacgaa gcagttcaaa t                                           21

<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
cgagtcagta tccagcccaa t                                           21

<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
cgggacaaag acaactaggt t                                           21

<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
caagttcatc aaggttcaca a                                           21

<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
acgagtggat ggtccgtact                                             20

<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
gtggcggatc gagttcttc                                              19

<210> 56
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
cttcgtctcc gccatcag                                               18

<210> 57
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
ttgccaatct ggacacca                                               18

<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
aagggtgaca gcaacagctc                                             20

<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
ttctgcacac gaatgaactt g                                           21

<210> 60
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
gggttgtttc aatctaacag tcaa                                        24

<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
caacattacg gattgtgtag cc                                          22

<210> 62
<211> 101
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu Ser Tyr Ala Asp Leu Ile
 1               5                  10                  15      
Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys Arg Leu Thr Leu Ser Gln
            20                  25                  30          
Ile Tyr Glu Trp Met Val Arg Cys Val Pro Tyr Phe Lys Asp Lys Gly
        35                  40                  45              
Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu
    50                  55                  60                  
Ser Leu His Ser Arg Phe Met Arg Val Gln Asn Glu Gly Thr Gly Lys
65                  70                  75                  80  
Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly Gly Lys Ser Gly Lys Ala
                85                  90                  95      
Pro Arg Arg Arg Ala
            100     


<210> 63
<211> 101
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Gly Ser Arg Arg Asn Ala Trp Gly Asn Gln Ser Tyr Ala Glu Leu Ile
 1               5                  10                  15      
Ser Gln Ala Ile Glu Ser Ala Pro Glu Lys Arg Leu Thr Leu Ala Gln
            20                  25                  30          
Ile Tyr Glu Trp Met Val Arg Thr Val Pro Tyr Phe Lys Asp Lys Gly
        35                  40                  45              
Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn Leu
    50                  55                  60                  
Ser Leu His Ser Lys Phe Ile Lys Val His Asn Glu Ala Thr Gly Lys
65                  70                  75                  80  
Ser Ser Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ala
                85                  90                  95      
Pro Arg Arg Arg Ala
            100     


<210> 64
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
Gly Tyr Arg Arg Pro Leu Ala His Ala Lys Pro Pro Tyr Ser Tyr Ile
 1               5                  10                  15      
Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Gly Lys Met Leu Thr
            20                  25                  30          
Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg
        35                  40                  45              
Glu Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe
    50                  55                  60                  
Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys
65                  70                  75                  80  
Gly Ser Tyr Trp Ala Leu His Pro Ser Ser Gly Asn Met Phe Glu Asn
                85                  90                  95      
Gly Cys Tyr Leu Arg Arg Gln Lys
            100                 


<210> 65
<211> 100
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
Asn Tyr Glu Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr
 1               5                  10                  15      
Ala Thr Leu Ile Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu
            20                  25                  30          
Thr Leu Asn Glu Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe
        35                  40                  45              
Arg Arg Asn Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser
    50                  55                  60                  
Leu His Lys Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp
65                  70                  75                  80  
Thr Val Asp Glu Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr
                85                  90                  95      
Gly Ser Pro Thr
            100 


<210> 66
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 66
Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met Glu
 1               5                  10                  15      
Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe Asn
            20                  25                  30          
Phe Asp Ser Leu Ile Ser Thr Gln Asn
        35                  40      


<210> 67
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 67
Asp Leu Asp Gly Met Phe Ile Glu Arg Leu Asp Cys Asp Met Glu Ser
 1               5                  10                  15      
Ile Ile Arg Asn Asp Leu Met Asp Gly Asp Thr Leu Asp Phe Asn Phe
            20                  25                  30          
Asp Asn Val Leu Pro Asn Gln Ser
        35                  40  


<210> 68
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 68
Asp Leu Asp Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp Met Asp
 1               5                  10                  15      
Asn Ile Ile Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp Phe Asn
            20                  25                  30          
Phe Glu Pro Asp Pro
        35          


