                         SEQUENCE LISTING

<110>  Global Bioenergies et al.
 
<120>  Method for the enzymatic production of isoprenol using mevalonate
        as a substrate

<130>  T2536 PCT S3

<150>  EP 12 16 3330.9
<151>  2012-04-05

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  324
<212>  PRT
<213>  Picrophilus torridus

<400>  1

Met Glu Asn Tyr Asn Val Lys Thr Arg Ala Phe Pro Thr Ile Gly Ile 
1               5                   10                  15      


Ile Leu Leu Gly Gly Ile Ser Asp Lys Lys Asn Arg Ile Pro Leu His 
            20                  25                  30          


Thr Thr Ala Gly Ile Ala Tyr Thr Gly Ile Asn Asn Asp Val Tyr Thr 
        35                  40                  45              


Glu Thr Lys Leu Tyr Val Ser Lys Asp Glu Lys Cys Tyr Ile Asp Gly 
    50                  55                  60                  


Lys Glu Ile Asp Leu Asn Ser Asp Arg Ser Pro Ser Lys Val Ile Asp 
65                  70                  75                  80  


Lys Phe Lys His Glu Ile Leu Met Arg Val Asn Leu Asp Asp Glu Asn 
                85                  90                  95      


Asn Leu Ser Ile Asp Ser Arg Asn Phe Asn Ile Leu Ser Gly Ser Ser 
            100                 105                 110         


Asp Ser Gly Ala Ala Ala Leu Gly Glu Cys Ile Glu Ser Ile Phe Glu 
        115                 120                 125             


Tyr Asn Ile Asn Ile Phe Thr Phe Glu Asn Asp Leu Gln Arg Ile Ser 
    130                 135                 140                 


Glu Ser Val Gly Arg Ser Leu Tyr Gly Gly Leu Thr Val Asn Tyr Ala 
145                 150                 155                 160 


Asn Gly Arg Glu Ser Leu Thr Glu Pro Leu Leu Glu Pro Glu Ala Phe 
                165                 170                 175     


Asn Asn Phe Thr Ile Ile Gly Ala His Phe Asn Ile Asp Arg Lys Pro 
            180                 185                 190         


Ser Asn Glu Ile His Glu Asn Ile Ile Lys His Glu Asn Tyr Arg Glu 
        195                 200                 205             


Arg Ile Lys Ser Ala Glu Arg Lys Ala Lys Lys Leu Glu Glu Leu Ser 
    210                 215                 220                 


Arg Asn Ala Asn Ile Lys Gly Ile Phe Glu Leu Ala Glu Ser Asp Thr 
225                 230                 235                 240 


Val Glu Tyr His Lys Met Leu His Asp Val Gly Val Asp Ile Ile Asn 
                245                 250                 255     


Asp Arg Met Glu Asn Leu Ile Glu Arg Val Lys Glu Met Lys Asn Asn 
            260                 265                 270         


Phe Trp Asn Ser Tyr Ile Val Thr Gly Gly Pro Asn Val Phe Val Ile 
        275                 280                 285             


Thr Glu Lys Lys Asp Val Asp Lys Ala Met Glu Gly Leu Asn Asp Leu 
    290                 295                 300                 


Cys Asp Asp Ile Arg Leu Leu Lys Val Ala Gly Lys Pro Gln Val Ile 
305                 310                 315                 320 


Ser Lys Asn Phe 
                


<210>  2
<211>  318
<212>  PRT
<213>  Thermoplasma acidophilum

<400>  2

Met Thr Tyr Arg Ser Ile Gly Ser Thr Ala Tyr Pro Thr Ile Gly Val 
1               5                   10                  15      


Val Leu Leu Gly Gly Ile Ala Asn Pro Val Thr Arg Thr Pro Leu His 
            20                  25                  30          


Thr Ser Ala Gly Ile Ala Tyr Ser Asp Ser Cys Gly Ser Ile Arg Ser 
        35                  40                  45              


Glu Thr Arg Ile Tyr Ala Asp Glu Ala Thr His Ile Tyr Phe Asn Gly 
    50                  55                  60                  


Thr Glu Ser Thr Asp Asp Asn Arg Ser Val Arg Arg Val Leu Asp Arg 
65                  70                  75                  80  


Tyr Ser Ser Val Phe Glu Glu Ala Phe Gly Thr Lys Thr Val Ser Tyr 
                85                  90                  95      


Ser Ser Gln Asn Phe Gly Ile Leu Ser Gly Ser Ser Asp Ala Gly Ala 
            100                 105                 110         


Ala Ser Ile Gly Ala Ala Ile Leu Gly Leu Lys Pro Asp Leu Asp Pro 
        115                 120                 125             


His Asp Val Glu Asn Asp Leu Arg Ala Val Ser Glu Ser Ala Gly Arg 
    130                 135                 140                 


Ser Leu Phe Gly Gly Leu Thr Ile Thr Trp Ser Asp Gly Phe His Ala 
145                 150                 155                 160 


Tyr Thr Glu Lys Ile Leu Asp Pro Glu Ala Phe Ser Gly Tyr Ser Ile 
                165                 170                 175     


Val Ala Phe Ala Phe Asp Tyr Gln Arg Asn Pro Ser Asp Val Ile His 
            180                 185                 190         


Gln Asn Ile Val Arg Ser Asp Leu Tyr Pro Ala Arg Lys Lys His Ala 
        195                 200                 205             


Asp Glu His Ala His Met Ile Lys Glu Tyr Ala Lys Thr Asn Asp Ile 
    210                 215                 220                 


Lys Gly Ile Phe Asp Leu Ala Gln Glu Asp Thr Glu Glu Tyr His Ser 
225                 230                 235                 240 


Ile Leu Arg Gly Val Gly Val Asn Val Ile Arg Glu Asn Met Gln Lys 
                245                 250                 255     


Leu Ile Ser Tyr Leu Lys Leu Ile Arg Lys Asp Tyr Trp Asn Ala Tyr 
            260                 265                 270         


Ile Val Thr Gly Gly Ser Asn Val Tyr Val Ala Val Glu Ser Glu Asn 
        275                 280                 285             


Ala Asp Arg Leu Phe Ser Ile Glu Asn Thr Phe Gly Ser Lys Lys Lys 
    290                 295                 300                 


Met Leu Arg Ile Val Gly Gly Ala Trp His Arg Arg Pro Glu 
305                 310                 315             


<210>  3
<211>  320
<212>  PRT
<213>  Thermoplasma volcanium

<400>  3

Met Ser Asn Ser Ser Ile Thr Ser Val Ala Tyr Pro Thr Ile Gly Val 
1               5                   10                  15      


Val Leu Leu Gly Gly Ile Ala Asn Glu Lys Thr Arg Thr Pro Leu His 
            20                  25                  30          


Thr Ser Ala Gly Ile Ala Tyr Thr Asp Ser Cys Gly Ser Ile Arg Thr 
        35                  40                  45              


Glu Ser Thr Ile Tyr Gly Asp Ser Glu Met His Ile Tyr Phe Asn Gly 
    50                  55                  60                  


Thr Glu Ser Lys Asp Glu Asn Arg Ser Val Lys Ser Val Leu Glu Arg 
65                  70                  75                  80  


Tyr Arg Asn Glu Leu Gln Ser Phe Phe Gly Lys Lys Asp Val Ser Tyr 
                85                  90                  95      


Ser Ser Leu Asn Tyr Gly Ile Leu Ser Gly Ser Ser Asp Ala Gly Ala 
            100                 105                 110         


Ala Ser Ile Gly Ala Ile Leu Ser Phe Ile Asp Lys Lys Asn Asp Ile 
        115                 120                 125             


His Asp Ile Glu Asn Asp Ile Arg Met Ile Ser Glu Ser Ala Gly Arg 
    130                 135                 140                 


Ser Leu His Gly Gly Leu Thr Ile Thr Trp Ser Asp Gly Tyr Ser Ala 
145                 150                 155                 160 


Tyr Thr Glu Arg Val Leu Gly Pro Glu His Phe Asn Asn Tyr Ala Ile 
                165                 170                 175     


Val Gly Phe Ser Phe Asp Tyr Pro Arg Asn Pro Ser Asp Thr Ile His 
            180                 185                 190         


Gln Asn Ile Ile Lys Ser Lys Arg Tyr Lys Gln Arg Thr Ile Asp Ala 
        195                 200                 205             


Asp Glu His Ala His Glu Ile Lys Glu Met Ala Arg Thr Asp Asp Ile 
    210                 215                 220                 


Glu Gly Ile Phe Glu Lys Ala Glu Glu Asp Thr Glu Glu Tyr His Ser 
225                 230                 235                 240 


Ile Leu Arg Glu Val Gly Val Leu Val Ile Arg Glu Asn Met Gln Lys 
                245                 250                 255     


Leu Ile Glu Phe Ile Lys Ile Leu Arg Lys Glu Phe Trp Asn Ser Tyr 
            260                 265                 270         


Ile Val Thr Gly Gly Ser Asn Val Tyr Val Ile Val Arg Arg Asp Asp 
        275                 280                 285             


Leu Glu Arg Leu Ile His Ile Lys Asn Thr Phe Gly Ser Lys Pro Lys 
    290                 295                 300                 


Ile Leu Asn Val Ala Gly Pro Ala Trp Ile Lys Lys Val Glu Ser Asp 
305                 310                 315                 320 


<210>  4
<211>  322
<212>  PRT
<213>  Ferroplasma acidarmanus fer1

<400>  4

Met Glu Lys Tyr Tyr Val Glu Val Lys Ala Tyr Pro Thr Ile Gly Ile 
1               5                   10                  15      


Leu Leu Leu Gly Gly Val Ser Asp Asn Lys Lys Arg Leu Pro Arg His 
            20                  25                  30          


Thr Thr Ala Gly Ile Ala Tyr Thr Gly Leu Asp Asp Asp Ile Tyr Val 
        35                  40                  45              


Lys Thr Asp Leu Tyr Leu Ser Asn Gln Lys Ser Gly Ile Ile Asn Gly 
    50                  55                  60                  


Lys Glu Val Ser Pro Asp Ser Pro Arg Ser Pro Phe Val Val Ile Asp 
65                  70                  75                  80  


Lys Tyr Arg His Glu Ile Leu Met Arg His Pro Glu Tyr Ser Glu Val 
                85                  90                  95      


Ser Phe Val Ser Glu Asn Lys Asn Val Ile Ser Gly Ser Ser Asp Ala 
            100                 105                 110         


Gly Ala Ala Ala Ile Gly Glu Cys Ile Gln Ser Ile Phe Glu Tyr Asn 
        115                 120                 125             


Ile Asn Ile Phe Asn Phe Glu Asn Asp Leu Gln Gln Ile Ser Glu Ser 
    130                 135                 140                 


Ala Gly Arg Ser Met Phe Gly Gly Phe Thr Ile Asn His Ala Asn Gly 
145                 150                 155                 160 


Lys Glu Ser Leu Thr Asp Glu Ile Leu Gly Pro Glu Asp Phe Glu Asp 
                165                 170                 175     


Phe Val Ile Val Ala Cys Lys Phe Ser Glu Asp Arg Lys Pro Ser Asp 
            180                 185                 190         


Thr Ile His Ser Asn Ile Ile Asn His Glu Lys Tyr Ala Glu Arg Val 
        195                 200                 205             


Lys Asn Ser Glu Leu Arg Ala Lys Glu Leu Glu Lys Met Ala Asp Ser 
    210                 215                 220                 


Gly Asp Ile Lys Gly Ile Phe Glu Ala Gly Glu Lys Asp Thr Gln Glu 
225                 230                 235                 240 


Tyr His Ser Met Leu Arg Glu Val Gly Val Ser Ile Ile Thr Asp Glu 
                245                 250                 255     


Met Gln Arg Leu Ile Glu Lys Val Glu Glu Leu Lys Ala Glu Phe Trp 
            260                 265                 270         


Asn Ala Tyr Ile Val Thr Gly Gly Thr Asn Val Phe Val Ala Val Glu 
        275                 280                 285             


Arg Lys Asn Met Glu Lys Met Lys Asn Ala Ala Met Glu Phe Lys Cys 
    290                 295                 300                 


Thr Pro Val Tyr Leu Lys Val Ala Gly Lys Pro Asp Val Ile Ser Lys 
305                 310                 315                 320 


Asn Phe 
        


<210>  5
<211>  315
<212>  PRT
<213>  Streptococcus gordonii

<400>  5

Met Asp Arg Lys Pro Val Ser Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Val Lys Tyr Trp Gly Lys Lys Asp Ala Glu Lys Met Ile Pro Ser Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Gln Leu 
        35                  40                  45              


Ser Pro Leu Pro Ala Thr Ala Thr Gly Asp Glu Phe Tyr Ile Asp Gly 
    50                  55                  60                  


Gln Leu Gln Ser Pro Ala Glu His Thr Lys Ile Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Phe Arg Ser Pro Glu Asp Gly Phe Val Arg Val Asp Thr Ser Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Gln Thr Gly Tyr Gln Ala 
        115                 120                 125             


Gln Glu Leu Ala Gln Leu Ala Lys Phe Ala Ser Gly Ser Ser Ala Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Leu Ala Ala Trp Asp Lys Asp Ser Gly Ala Ile 
145                 150                 155                 160 


Tyr Pro Val Lys Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


His Asp Glu Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Glu Leu Cys 
            180                 185                 190         


Ala Lys Thr Ser Thr Ile Phe Pro Asp Trp Ile Ala Gln Ser Ala Leu 
        195                 200                 205             


Asp Tyr Gln Ala Met Leu Ala Tyr Leu Arg Asp Asn Glu Phe Ala Lys 
    210                 215                 220                 


Val Gly Gln Leu Thr Glu Glu Asn Ala Leu Arg Met His Ala Thr Thr 
225                 230                 235                 240 


Glu Lys Ala Tyr Pro Pro Phe Ser Tyr Leu Thr Glu Glu Ser Tyr Gln 
                245                 250                 255     


Ala Met Asp Ala Val Arg Lys Leu Arg Glu Gln Gly Glu Arg Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Asp His Leu Ala Ala Ile Leu Glu Lys Asp Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Asp Glu Ser 
305                 310                 315 


<210>  6
<211>  315
<212>  PRT
<213>  Streptococcus gordonii str. Challis substr. CH1

<400>  6

Met Asp Arg Lys Pro Val Ser Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Val Lys Tyr Trp Gly Lys Lys Asp Ala Glu Lys Met Ile Pro Ser Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Gln Leu 
        35                  40                  45              


Ser Pro Leu Pro Asp Thr Ala Thr Gly Asp Glu Phe Tyr Ile Asp Gly 
    50                  55                  60                  


Gln Leu Gln Ser Pro Ala Glu His Ala Lys Ile Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Phe Arg Ser Pro Glu Asp Gly Phe Val Arg Val Asp Thr Ser Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Gln Thr Gly Tyr Gln Thr 
        115                 120                 125             


Glu Glu Leu Ala Gln Leu Ala Lys Phe Ala Ser Gly Ser Ser Ala Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Leu Ala Ala Trp Asp Lys Asp Ser Gly Ala Ile 
145                 150                 155                 160 


Tyr Pro Val Lys Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


His Asp Glu Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Glu Leu Cys 
            180                 185                 190         


Ala Lys Thr Ser Thr Ile Phe Pro Asp Trp Ile Ala Gln Ser Ala Leu 
        195                 200                 205             


Asp Tyr Gln Ala Met Leu Gly Tyr Leu Gln Asp Asn Asp Phe Ala Lys 
    210                 215                 220                 


Val Gly Gln Leu Thr Glu Glu Asn Ala Leu Arg Met His Ala Thr Thr 
225                 230                 235                 240 


Glu Lys Ala Tyr Pro Pro Phe Ser Tyr Leu Thr Glu Glu Ser Tyr Gln 
                245                 250                 255     


Ala Met Asp Ala Val Arg Lys Leu Arg Glu Gln Gly Glu Arg Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Asp His Leu Ala Ala Ile Phe Glu Lys Asp Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Asp Glu Ser 
305                 310                 315 


<210>  7
<211>  311
<212>  PRT
<213>  Streptococcus infantarius subsp infantarius ATCC BAA-102

<400>  7

Met Asp Arg Lys Ile Val Thr Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Ala Asp Ala Ala Lys Met Ile Pro Ala Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Phe Thr Thr Thr Ser Val 
        35                  40                  45              


Ser Phe Leu Pro Asp Ser Ala Ser His Asp Glu Phe Tyr Ile Asn Gly 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Glu His Ala Lys Ile Ser Ala Ile Ile Asp 
65                  70                  75                  80  


Gln Tyr Arg Gly Gln Arg Ser Glu Tyr Val Lys Val Glu Thr Ser Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Glu Leu Phe Glu Thr Gly Leu Thr Arg 
        115                 120                 125             


Ala Glu Leu Ala Gln Lys Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Leu Ala Ala Trp Asp Lys Asp Ser Gly Glu Val 
145                 150                 155                 160 


Tyr Pro Val Gln Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Ser Asp Ser Lys Lys Ser Ile Ser Ser Arg Glu Gly Met Lys Arg Cys 
            180                 185                 190         


Val Glu Thr Ser Thr Thr Phe Ala Asp Trp Val Lys Gln Ser Glu Gln 
        195                 200                 205             


Asp Tyr Lys Asp Met Leu Gly Tyr Leu Lys Asn Asn Asp Phe Glu Arg 
    210                 215                 220                 


Val Gly Glu Leu Thr Glu Arg Asn Ala Leu Ala Met His Asp Thr Asn 
225                 230                 235                 240 


Thr His Ala Asn Pro Pro Phe Asn Tyr Leu Thr Glu Glu Ser Tyr Lys 
                245                 250                 255     


Ala Met Glu Phe Val Lys Gln Leu Arg Ser Glu Gly Glu Lys Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Glu Arg Leu Thr Lys Arg Phe Glu Glu Asn Tyr Arg Val Ile 
    290                 295                 300                 


Val Ser Arg Thr Lys Glu Leu 
305                 310     


<210>  8
<211>  391
<212>  PRT
<213>  Dictyostelium discoideum

<400>  8

Met Val Leu Ala Ser Val Thr Cys Thr Ala Pro Val Asn Ile Ala Val 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Arg Asp Glu Asn Ile Ile Leu Pro Leu Asn 
            20                  25                  30          


Ser Ser Leu Ser Gly Thr Leu His Gln Asp Asp Leu Lys Thr Thr Thr 
        35                  40                  45              


Thr Ile Val Ala Ser Glu Asp Tyr Thr Glu Asp Glu Leu Tyr Leu Asn 
    50                  55                  60                  


Gly Lys Lys Glu Asp Ile Asn Ala Val Arg Tyr Gln Asn Val Leu Lys 
65                  70                  75                  80  


Met Ile Arg Ser Arg Ala Thr Lys Leu Met Asp Lys Lys His Cys Val 
                85                  90                  95      


His Ile Ala Ser Ile Asn Asn Phe Pro Thr Ala Ala Gly Leu Ala Ser 
            100                 105                 110         


Ser Ala Ser Gly Tyr Cys Cys Leu Val Phe Thr Leu Ala Gln Met Tyr 
        115                 120                 125             


Gly Val Asp Gly Asp Ile Ser Gly Ile Ala Arg Leu Gly Ser Gly Ser 
    130                 135                 140                 


Ala Cys Arg Ser Met Tyr Gly Gly Phe Val Lys Trp Glu Met Gly Thr 
145                 150                 155                 160 


Lys Asp Asp Gly Ser Asp Ser Ile Ala Val Gln Val Gln Pro Glu Ser 
                165                 170                 175     


His Trp Pro Asp Met Asn Ile Ile Val Leu Val Val Asn Asp Lys Lys 
            180                 185                 190         


Lys Glu Thr Ser Ser Thr Asp Gly Met Gln Lys Ser Ala Ala Thr Ser 
        195                 200                 205             


Val Met Met Lys Glu Arg Cys Ala Val Thr Val Pro Asn Arg Met Arg 
    210                 215                 220                 


Asp Ile Glu Glu Ala Ile Asn Lys Lys Asp Phe Gln Thr Phe Gly Asp 
225                 230                 235                 240 


Ile Thr Met Lys Asp Ser Asp Asp Phe His Glu Val Cys Ala Thr Thr 
                245                 250                 255     


Thr Pro Pro Ile Tyr Tyr Leu Asn Asp Thr Ser Arg Tyr Ile Met Asn 
            260                 265                 270         


Leu Ile His Arg Tyr Asn Lys Leu Ser Gly Ser Ile Lys Cys Ala Tyr 
        275                 280                 285             


Thr Phe Asp Ala Gly Pro Asn Ala Cys Ile Tyr Leu Pro Ala Glu Ser 
    290                 295                 300                 


Thr Thr Glu Val Leu Ser Leu Phe Met Lys His Phe Pro Gly Asp Asp 
305                 310                 315                 320 


Met Gln Thr Tyr Tyr Arg Gly Pro Lys Glu Asn Ile Pro Ser Ile Glu 
                325                 330                 335     


Asn Phe Val Pro Ser Glu Lys Leu Ala Ser Leu Tyr Thr Pro Asp Thr 
            340                 345                 350         


Thr Phe Val Asn Ser Leu Lys Tyr Ile Leu His Thr Lys Val Gly Pro 
        355                 360                 365             


Gly Pro Gln Ile Leu Ser Glu Ser Glu Ser Leu Ile Asp Asn Thr Thr 
    370                 375                 380                 


Gly Leu Pro Lys Gln Leu Asn 
385                 390     


<210>  9
<211>  319
<212>  PRT
<213>  Lactobacillus delbrueckii

<400>  9

Met Ser Lys Thr Ala Arg Ala His Thr Asn Ile Ala Leu Ile Lys Tyr 
1               5                   10                  15      


Trp Gly Lys Lys Asp Ala Lys Leu Arg Leu Pro Leu Met Ser Ser Leu 
            20                  25                  30          


Ser Met Thr Leu Asp Ala Phe Tyr Ser Asp Thr Lys Ile Ser Asp Ser 
        35                  40                  45              


Glu Gln Met Ser Phe Lys Leu Asn Gly Gln Ala Val Ser Gly Pro Ala 
    50                  55                  60                  


Ala Asp Arg Val Phe Ala Tyr Leu Arg Ala Met Gln Asp Arg Phe Gly 
65                  70                  75                  80  


Val Lys Gly Asn Leu Ala Val Glu Ser Val Asn Gln Val Pro Thr Ala 
                85                  90                  95      


Ala Gly Leu Ala Ser Ser Ser Ser Ala Phe Ala Ala Met Ala Ala Ala 
            100                 105                 110         


Phe Ala Asp His Tyr Gln Leu Gly Val Asp Arg Gln Glu Leu Ser Arg 
        115                 120                 125             


Met Ala Arg Met Gly Ser Gly Ser Ala Ser Arg Ser Val Phe Gly Gly 
    130                 135                 140                 


Phe Ser Val Trp Gln Lys Gly Asp Ser Asp Gln Thr Ser Tyr Ala Tyr 
145                 150                 155                 160 


Pro Leu Asp Glu Glu Pro Asp Met Asp Leu Arg Leu Leu Ala Val Glu 
                165                 170                 175     


Ile Asn Asp Gln Glu Lys Lys Ile Ser Ser Thr Lys Gly Met Glu Met 
            180                 185                 190         


Ser Lys Ser Ser Pro Phe Tyr Gln Val Trp Leu Asp Arg Asn Asp Ser 
        195                 200                 205             


Glu Ile Lys Glu Met Glu Glu Ala Ile Lys Gln Ala Asp Phe Ser Lys 
    210                 215                 220                 


Leu Gly Ser Leu Ala Glu Leu Asn Ala Ser Glu Met His Thr Leu Thr 
225                 230                 235                 240 


Phe Thr Ala Val Pro Gly Phe Thr Tyr Phe Glu Pro Asn Thr Ile Lys 
                245                 250                 255     


Ala Ile Lys Leu Val Gln Asp Leu Arg Gln Gln Gly Leu Glu Cys Tyr 
            260                 265                 270         


Tyr Thr Ile Asp Ala Gly Pro Asn Val Lys Val Leu Cys Gln Gly Lys 
        275                 280                 285             


Asn Ser Lys Asp Ile Ile Asn Cys Phe Glu Ser Ser Phe Asp Arg Val 
    290                 295                 300                 


Lys Ile Ile Glu Ala Gly Phe Gly Pro Gly Val Thr Leu Leu Asp 
305                 310                 315                 


<210>  10
<211>  317
<212>  PRT
<213>  Streptococcus mitis (strain B6)

<400>  10

Met Asp Arg Glu Pro Val Thr Val Arg Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Lys Lys Glu Lys Glu Met Val Pro Ala Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Thr Leu 
        35                  40                  45              


Ser Ser Leu Pro Thr Asp Ala Thr Ala Asp Ala Phe Tyr Ile Asn Gly 
    50                  55                  60                  


Gln Leu Gln Asn Glu Ala Glu His Val Lys Met Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Tyr Arg Pro Asp Gly Asp Gly Phe Val Arg Ile Asp Thr Gln Asn 
                85                  90                  95      


Ser Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Lys Leu Gly Leu Asn Arg 
        115                 120                 125             


Ser Gln Leu Ala Gln Glu Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Tyr Gly Pro Leu Gly Ala Trp Asp Lys Asp Ser Gly Glu Ile 
145                 150                 155                 160 


Tyr Pro Val Glu Thr Gly Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Glu Asp Lys Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Lys Leu Cys 
            180                 185                 190         


Val Glu Thr Ser Thr Thr Phe Asp Asp Trp Val Arg Gln Ser Glu Lys 
        195                 200                 205             


Asp Tyr Gln Asp Met Leu Val Tyr Leu Lys Ala Asn Asp Phe Ala Lys 
    210                 215                 220                 


Val Gly Glu Leu Thr Glu Lys Asn Ala Leu Ala Met His Ala Thr Thr 
225                 230                 235                 240 


Lys Thr Ala Ser Pro Ala Phe Ser Tyr Leu Thr Asp Ala Ser Tyr Glu 
                245                 250                 255     


Ala Met Asp Phe Val Arg Gln Leu Arg Glu Gln Gly Glu Ala Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Gln Glu Lys 
        275                 280                 285             


Asp Leu Glu His Leu Ser Glu Ile Phe Gly Gln Arg Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Gln Asp Gly Cys Cys 
305                 310                 315         


<210>  11
<211>  316
<212>  PRT
<213>  Streptococcus gallolyticus UCN34

<400>  11

Met Asp Arg Lys Ile Val Thr Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Ala Asp Ala Val Lys Met Ile Pro Ala Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Phe Thr Thr Thr Thr Val 
        35                  40                  45              


Ser Phe Leu Pro Gln Ser Val Gly His Asp Glu Phe Tyr Ile Asn Gly 
    50                  55                  60                  


Val Leu Gln Asp Glu Lys Glu His Ala Lys Ile Ser Ala Ile Ile Asp 
65                  70                  75                  80  


Gln Tyr Arg Gly Gly Arg Ser Glu Phe Val Lys Val Glu Thr Ser Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Glu Leu Phe Glu Thr Gly Leu Asn Gln 
        115                 120                 125             


Ser Glu Leu Ala Gln Lys Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Ile Ala Ala Trp Asp Lys Asp Ser Gly Asp Ile 
145                 150                 155                 160 


Tyr Pro Val Gln Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Ser Asp Ser Lys Lys Pro Ile Ser Ser Arg Glu Gly Met Lys Arg Cys 
            180                 185                 190         


Ala Glu Thr Ser Thr Thr Phe Ala Asp Trp Val Lys Gln Ser Glu Gln 
        195                 200                 205             


Asp Tyr Lys Asp Met Leu Ala Tyr Leu Lys Ala Asn Asp Phe Glu Lys 
    210                 215                 220                 


Val Gly Glu Leu Thr Glu Arg Asn Ala Leu Ala Met His Asp Thr Asn 
225                 230                 235                 240 


Thr His Ala Asn Pro Pro Phe Asn Tyr Leu Thr Asp Glu Thr Tyr Ala 
                245                 250                 255     


Ala Met Asp Phe Val Lys Ser Leu Arg Thr Gln Gly Glu Lys Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Glu Cys Leu Thr Lys Arg Phe Glu Glu Asn Tyr Arg Val Ile 
    290                 295                 300                 


Ala Ser Arg Thr Lys Val Leu Pro Asp Glu Asn Asp 
305                 310                 315     


<210>  12
<211>  315
<212>  PRT
<213>  Streptococcus sanguinis SK36

<400>  12

Met Asp Arg Lys Pro Val Ser Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Val Lys Tyr Trp Gly Lys Lys Asp Ala Glu Lys Met Ile Pro Ser Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Gln Leu 
        35                  40                  45              


Ser Pro Leu Pro Asp Thr Ala Thr Gly Asp Glu Phe Tyr Ile Asp Ser 
    50                  55                  60                  


Gln Leu Gln Ser Pro Ala Glu His Ala Lys Ile Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Phe Arg Ser Pro Glu Asp Gly Phe Val Arg Val Asp Thr Ser Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Gln Thr Gly Tyr Gln Thr 
        115                 120                 125             


Gln Glu Leu Ala Gln Leu Ala Lys Phe Ala Ser Gly Ser Ser Ala Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Leu Ala Ala Trp Asp Lys Asp Ser Gly Ala Ile 
145                 150                 155                 160 


Tyr Pro Val Lys Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


His Asp Glu Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Glu Leu Cys 
            180                 185                 190         


Ala Lys Thr Ser Thr Ile Phe Pro Asp Trp Ile Ala Gln Ser Ala Leu 
        195                 200                 205             


Asp Tyr Lys Ala Met Leu Ser Tyr Leu Gln Asp Asn Asp Phe Ala Lys 
    210                 215                 220                 


Val Gly Gln Leu Thr Glu Glu Asn Ala Leu Arg Met His Ala Thr Thr 
225                 230                 235                 240 


Glu Lys Ala Tyr Pro Pro Phe Ser Tyr Leu Thr Glu Glu Ser Tyr Gln 
                245                 250                 255     


Ala Met Asp Ala Val Arg Lys Leu Arg Glu Gln Gly Glu Arg Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Asp His Leu Val Ala Ile Phe Glu Lys Asp Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Asp Glu Asp 
305                 310                 315 


<210>  13
<211>  317
<212>  PRT
<213>  Streptococcus sp. M143

<400>  13

Met Asp Arg Lys Pro Val Thr Val Arg Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Lys Lys Glu Lys Glu Met Val Pro Ala Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Thr Leu 
        35                  40                  45              


Ser Pro Leu Pro Thr Asp Ala Thr Ala Asp Ala Phe Tyr Ile Asn Gly 
    50                  55                  60                  


Gln Leu Gln Ser Glu Ala Glu His Ala Lys Met Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Tyr Arg Pro Ala Gly Glu Gly Phe Val Arg Ile Asp Thr Gln Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Gln Leu Gly Leu Asn Arg 
        115                 120                 125             


Ser Gln Leu Ala Gln Glu Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Tyr Gly Pro Leu Gly Ala Trp Asp Lys Asp Ser Gly Glu Ile 
145                 150                 155                 160 


Tyr Pro Val Glu Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Glu Asp Lys Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Lys Leu Cys 
            180                 185                 190         


Val Glu Thr Ser Thr Thr Phe Asp Asp Trp Val Arg Gln Ser Glu Lys 
        195                 200                 205             


Asp Tyr Gln Asp Met Leu Leu Tyr Leu Lys Glu Asn Asp Phe Ala Lys 
    210                 215                 220                 


Val Gly Glu Leu Thr Glu Lys Asn Ala Leu Ala Met His Ala Thr Thr 
225                 230                 235                 240 


Lys Thr Ala Ser Pro Ala Phe Ser Tyr Leu Thr Asp Ala Ser Tyr Glu 
                245                 250                 255     


Ala Met Asp Phe Val Arg Gln Leu Arg Glu Gln Gly Glu Ser Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Gln Glu Glu 
        275                 280                 285             


Asp Leu Glu His Leu Ser Glu Ile Phe Gly Gln Arg Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Gln Asp Asp Cys Cys 
305                 310                 315         


<210>  14
<211>  341
<212>  PRT
<213>  Streptococcus suis 89/1591

<400>  14

Met Thr Lys Gln Ile Gly Ile Ala Arg Ala His Thr Asn Ile Ala Leu 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Arg Asp Lys Glu Leu Phe Leu Pro Met Asn 
            20                  25                  30          


Ser Ser Leu Ser Leu Thr Leu Asp Ala Phe Tyr Thr Asp Thr Lys Val 
        35                  40                  45              


Val Phe Asp Pro Glu Leu Thr Ala Asp Glu Phe Tyr Leu Asn Gly Met 
    50                  55                  60                  


Leu Gln Lys Glu Lys Glu Ile Leu Lys Ile Ser Arg Phe Leu Asp Leu 
65                  70                  75                  80  


Phe Cys Glu Tyr Ile Gly Glu Arg Ala Phe Ala Arg Val Glu Ser Leu 
                85                  90                  95      


Asn Phe Val Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ser Ala Phe 
            100                 105                 110         


Ala Ala Leu Ala Leu Ala Thr Ala Thr Ala Leu Asp Leu Asp Leu Ser 
        115                 120                 125             


Pro Ala Thr Leu Ser Thr Leu Ala Arg Arg Gly Ser Gly Ser Ser Thr 
    130                 135                 140                 


Arg Ser Leu Phe Gly Gly Phe Val Glu Trp Asp Met Gly Thr Gly Ser 
145                 150                 155                 160 


Glu Asp Ser Met Ala His Pro Ile Asp Asp Ala Asp Trp Asp Ile Gly 
                165                 170                 175     


Met Val Val Leu Ala Val Asn Thr Gly Pro Lys Lys Ile Ala Ser Arg 
            180                 185                 190         


Glu Gly Met Asp His Thr Val Ala Thr Ser Pro Phe Tyr Ser Ala Trp 
        195                 200                 205             


Val Asp Thr Ala Lys Gln Asp Leu Ala Asp Ile Lys Ala Ala Ile Ala 
    210                 215                 220                 


Gly Arg Asp Phe Glu Lys Leu Gly Gln Ile Thr Glu His Asn Gly Met 
225                 230                 235                 240 


Lys Met His Ala Thr Thr Leu Ser Ala Asn Pro Pro Phe Thr Tyr Trp 
                245                 250                 255     


Ser Ala Asp Ser Leu Val Ala Gln Glu Ala Val Arg Gln Val Arg Glu 
            260                 265                 270         


Ala Thr Gly Leu Ser Ala Tyr Met Thr Met Asp Ala Gly Pro Asn Val 
        275                 280                 285             


Lys Val Leu Cys Arg Ala Ser Gln Met Asp Glu Leu Val Ala Glu Leu 
    290                 295                 300                 


Ala Lys Val Phe Pro Arg Glu Lys Ile Ile Thr Ser Lys Pro Gly Pro 
305                 310                 315                 320 


Ala Ala Tyr Val Leu Ser Glu Asp Glu Trp Gln Thr Ser Gln Ala Ala 
                325                 330                 335     


Phe Glu Lys Gly Leu 
            340     


<210>  15
<211>  314
<212>  PRT
<213>  Streptococcus salivarius SK126

<400>  15

Met Asp Arg Lys Pro Val Ser Val Lys Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Val Lys Tyr Trp Gly Lys Ala Asp Ala Glu Arg Met Ile Pro Ser Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Lys Leu 
        35                  40                  45              


Ser Phe Leu Pro Glu Asp Ala Thr Gly Asp Val Met Tyr Ile Asp Asp 
    50                  55                  60                  


Glu Leu Gln Gly Glu Lys Glu Thr Thr Lys Ala Ser Lys Val Leu Asp 
65                  70                  75                  80  


Leu Phe Arg Asn Asn Ser Asn Gln His Val Lys Ile Glu Thr Trp Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Ala Asn Glu Leu Phe Gln Val Gly Lys Thr Gln 
        115                 120                 125             


Ser Glu Leu Ala Gln Ile Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Phe Gly Pro Leu Ala Ala Trp Asp Lys Asp Ser Gly Glu Val 
145                 150                 155                 160 


Tyr Pro Val Glu Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Thr Asp Gln Lys Lys Pro Val Ser Ser Arg Asp Gly Met Lys Leu Cys 
            180                 185                 190         


Thr Glu Thr Ser Thr Ser Phe Pro Glu Trp Ile Lys Gln Ser Glu Leu 
        195                 200                 205             


Asp Tyr Lys Asp Met Leu Ala Tyr Leu Lys Ala Asn Asp Phe Gln Ala 
    210                 215                 220                 


Val Gly Glu Leu Thr Glu Ala Asn Ala Leu Arg Met His Gln Thr Thr 
225                 230                 235                 240 


Ser Thr Ala Asn Pro Pro Phe Ser Tyr Leu Thr Glu Ala Ser Tyr Gln 
                245                 250                 255     


Ala Met Asp Lys Val Lys Ala Leu Arg Ala Ser Gly Glu Gln Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Leu Cys Leu Glu Glu 
        275                 280                 285             


Asp Leu Asp Arg Leu Ala Glu His Phe Arg Lys Asp Tyr Gln Val Ile 
    290                 295                 300                 


Val Ser Arg Thr Lys Glu Leu Pro Asp Ala 
305                 310                 


<210>  16
<211>  325
<212>  PRT
<213>  Thermoplasma acidophilum

<400>  16

Met Leu His His His His His His Thr Tyr Arg Ser Ile Gly Ser Thr 
1               5                   10                  15      


Ala Tyr Pro Thr Ile Gly Val Val Leu Leu Gly Gly Ile Ala Asn Pro 
            20                  25                  30          


Val Thr Arg Thr Pro Leu His Thr Ser Ala Gly Ile Ala Tyr Ser Asp 
        35                  40                  45              


Ser Cys Gly Ser Ile Arg Ser Glu Thr Arg Ile Tyr Ala Asp Glu Ala 
    50                  55                  60                  


Thr His Ile Tyr Phe Asn Gly Thr Glu Ser Thr Asp Asp Asn Arg Ser 
65                  70                  75                  80  


Val Arg Arg Val Leu Asp Arg Tyr Ser Ser Val Phe Glu Glu Ala Phe 
                85                  90                  95      


Gly Thr Lys Thr Val Ser Tyr Ser Ser Gln Asn Phe Gly Ile Leu Ser 
            100                 105                 110         


Gly Ser Ser Asp Ala Gly Ala Ala Ser Ile Gly Ala Ala Ile Leu Gly 
        115                 120                 125             


Leu Lys Pro Asp Leu Asp Pro His Asp Val Glu Asn Asp Leu Arg Ala 
    130                 135                 140                 


Val Ser Glu Ser Ala Gly Arg Ser Leu Phe Gly Gly Leu Thr Ile Thr 
145                 150                 155                 160 


Trp Ser Asp Gly Phe His Ala Tyr Thr Glu Lys Ile Leu Asp Pro Glu 
                165                 170                 175     


Ala Phe Ser Gly Tyr Ser Ile Val Ala Phe Ala Phe Asp Tyr Gln Arg 
            180                 185                 190         


Asn Pro Ser Asp Val Ile His Gln Asn Ile Val Arg Ser Asp Leu Tyr 
        195                 200                 205             


Pro Ala Arg Lys Lys His Ala Asp Glu His Ala His Met Ile Lys Glu 
    210                 215                 220                 


Tyr Ala Lys Thr Asn Asp Ile Lys Gly Ile Phe Asp Leu Ala Gln Glu 
225                 230                 235                 240 


Asp Thr Glu Glu Tyr His Ser Ile Leu Arg Gly Val Gly Val Asn Val 
                245                 250                 255     


Ile Arg Glu Asn Met Gln Lys Leu Ile Ser Tyr Leu Lys Leu Ile Arg 
            260                 265                 270         


Lys Asp Tyr Trp Asn Ala Tyr Ile Val Thr Gly Gly Ser Asn Val Tyr 
        275                 280                 285             


Val Ala Val Glu Ser Glu Asn Ala Asp Arg Leu Phe Ser Ile Glu Asn 
    290                 295                 300                 


Thr Phe Gly Ser Lys Lys Lys Met Leu Arg Ile Val Gly Gly Ala Trp 
305                 310                 315                 320 


His Arg Arg Pro Glu 
                325 


<210>  17
<211>  267
<212>  PRT
<213>  Methanosarcina mazei

<400>  17

Met Glu Met Arg Gln Pro Ala Val Ala Gly Gln Phe Tyr Pro Leu Arg 
1               5                   10                  15      


Cys Glu Asn Leu Glu Asn Glu Leu Lys Arg Cys Phe Glu Gly Leu Glu 
            20                  25                  30          


Ile Arg Glu Gln Glu Val Leu Gly Ala Val Cys Pro His Ala Gly Tyr 
        35                  40                  45              


Met Tyr Ser Gly Lys Val Ala Ala His Val Tyr Ala Thr Leu Pro Glu 
    50                  55                  60                  


Ala Asp Thr Tyr Val Ile Phe Gly Pro Asn His Thr Gly Tyr Gly Ser 
65                  70                  75                  80  


Pro Val Ser Val Ser Arg Glu Thr Trp Lys Thr Pro Leu Gly Asn Ile 
                85                  90                  95      


Asp Val Asp Leu Glu Leu Ala Asp Gly Phe Leu Gly Ser Ile Val Asp 
            100                 105                 110         


Ala Asp Glu Leu Gly His Lys Tyr Glu His Ser Ile Glu Val Gln Leu 
        115                 120                 125             


Pro Phe Leu Gln Tyr Arg Phe Glu Arg Asp Phe Lys Ile Leu Pro Ile 
    130                 135                 140                 


Cys Met Gly Met Gln Asp Glu Glu Thr Ala Val Glu Val Gly Asn Leu 
145                 150                 155                 160 


Leu Ala Asp Leu Ile Ser Glu Ser Gly Lys Arg Ala Val Ile Ile Ala 
                165                 170                 175     


Ser Ser Asp Phe Thr His Tyr Glu Thr Ala Glu Arg Ala Lys Glu Ile 
            180                 185                 190         


Asp Ser Glu Val Ile Asp Ser Ile Leu Asn Phe Asp Ile Ser Gly Met 
        195                 200                 205             


Tyr Asp Arg Leu Tyr Arg Arg Asn Ala Ser Val Cys Gly Tyr Gly Pro 
    210                 215                 220                 


Ile Thr Ala Met Leu Thr Ala Ser Lys Lys Leu Gly Gly Ser Arg Ala 
225                 230                 235                 240 


Thr Leu Leu Lys Tyr Ala Asn Ser Gly Asp Val Ser Gly Asp Lys Asp 
                245                 250                 255     


Ala Val Val Gly Tyr Ala Ala Ile Ile Val Glu 
            260                 265         


<210>  18
<211>  326
<212>  PRT
<213>  Sulfolobus tokodaii

<400>  18

Met Arg Leu Glu Ala Glu Ala Ile Ala Pro Ser Asn Ile Ala Ile Ile 
1               5                   10                  15      


Lys Tyr Trp Gly Lys Arg Asn Glu Glu Leu Asn Leu Pro Leu Asn Ser 
            20                  25                  30          


Ser Leu Ser Val Thr Leu Ser Gly Leu Glu Val Lys Thr Lys Ile Thr 
        35                  40                  45              


Phe Ser Lys Glu Phe Thr Lys Asp Glu Val Tyr Ile Asn Gly Glu Arg 
    50                  55                  60                  


Ala Lys Asp Glu Glu Val Lys Glu Tyr Ser Gly Arg Val Leu Asn Ile 
65                  70                  75                  80  


Phe Arg Lys Leu Tyr Gly Lys Glu Ile Tyr Ala Lys Val Glu Ser Trp 
                85                  90                  95      


Ser Asn Phe Pro Lys Ser Thr Gly Leu Ala Ser Ser Ala Ala Gly Ile 
            100                 105                 110         


Ala Ala Leu Val Tyr Ala Thr Asn Glu Ala Leu Glu Leu Gly Leu Ser 
        115                 120                 125             


Gln Lys Glu Leu Ser Lys Ile Ala Arg Ile Gly Ser Gly Ser Ala Cys 
    130                 135                 140                 


Arg Ser Thr Ala Gly Gly Phe Val Leu Trp Glu Lys Gly Glu Arg Asp 
145                 150                 155                 160 


Asp Gly Glu Asp Ser Tyr Cys Tyr Ser Leu Phe Pro Glu Asn His Trp 
                165                 170                 175     


Lys Glu Leu Val Asp Ile Ile Ala Ile Val Ser Glu Lys Ser Lys Lys 
            180                 185                 190         


Ile Ser Ser Arg Glu Gly Met Ile Ile Thr Ala Lys Thr Ser Asn Leu 
        195                 200                 205             


Met Lys Cys Arg Leu Lys Phe Ile Glu Glu Thr Leu Pro Lys Val Ile 
    210                 215                 220                 


Lys Ser Ile Glu Glu Arg Asn Glu Lys Glu Phe Tyr Tyr Trp Leu Met 
225                 230                 235                 240 


Arg His Ser Asn Ser Met His Ala Val Ile Leu Asp Ser Trp Pro Ser 
                245                 250                 255     


Phe Phe Tyr Leu Asn Asp Thr Ser Leu Lys Ile Met Glu Trp Ile Gln 
            260                 265                 270         


Glu Phe Gly Lys Ala Gly Tyr Thr Phe Asp Ala Gly Pro Asn Pro His 
        275                 280                 285             


Ile Phe Thr Thr Glu Lys Tyr Lys Asp Glu Val Ile Arg Phe Leu Asn 
    290                 295                 300                 


Ser Ile Gly Val Asn Lys Ile Ile Ile Ser Lys Val Gly Ser Gly Pro 
305                 310                 315                 320 


Lys Val Asn Lys Leu Leu 
                325     


<210>  19
<211>  317
<212>  PRT
<213>  Streptococcus pneumonia

<400>  19

Met Asp Arg Glu Pro Val Thr Val Arg Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      


Ile Lys Tyr Trp Gly Lys Lys Lys Glu Lys Glu Met Val Pro Ala Thr 
            20                  25                  30          


Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Thr Leu 
        35                  40                  45              


Ser Pro Leu Pro Ala Asn Val Thr Ala Asp Glu Phe Tyr Ile Asn Gly 
    50                  55                  60                  


Gln Leu Gln Asn Glu Val Glu His Ala Lys Met Ser Lys Ile Ile Asp 
65                  70                  75                  80  


Arg Tyr Arg Pro Ala Gly Glu Gly Phe Val Arg Ile Asp Thr Gln Asn 
                85                  90                  95      


Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         


Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Lys Leu Gly Leu Asp Arg 
        115                 120                 125             


Ser Gln Leu Ala Gln Glu Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 


Ser Phe Tyr Gly Pro Leu Gly Ala Trp Asp Lys Asp Ser Gly Glu Ile 
145                 150                 155                 160 


Tyr Pro Val Glu Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     


Glu Asp Lys Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Lys Leu Cys 
            180                 185                 190         


Val Glu Thr Ser Thr Thr Phe Asp Asp Trp Val Arg Gln Ser Glu Lys 
        195                 200                 205             


Asp Tyr Gln Asp Met Leu Ile Tyr Leu Lys Glu Asn Asp Phe Ala Lys 
    210                 215                 220                 


Ile Gly Glu Leu Thr Glu Lys Asn Ala Leu Ala Met His Ala Thr Thr 
225                 230                 235                 240 


Lys Thr Ala Ser Pro Ala Phe Ser Tyr Leu Thr Asp Ala Ser Tyr Glu 
                245                 250                 255     


Ala Met Ala Phe Val Arg Gln Leu Arg Glu Lys Gly Glu Ala Cys Tyr 
            260                 265                 270         


Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Phe Cys Gln Glu Lys 
        275                 280                 285             


Asp Leu Glu His Leu Ser Glu Ile Phe Gly Gln Arg Tyr Arg Leu Ile 
    290                 295                 300                 


Val Ser Lys Thr Lys Asp Leu Ser Gln Asp Asp Cys Cys 
305                 310                 315         


<210>  20
<211>  389
<212>  PRT
<213>  Chloroflexus aggregans

<400>  20

Met Asn Glu Ser Ser Ile Pro Gln Gly Phe Ala Asp Leu Val Ala Pro 
1               5                   10                  15      


Met Arg Thr Ala His Glu Arg Ile Ile Ala Asp Leu Arg Arg His His 
            20                  25                  30          


Ile Glu Leu Pro Pro Pro Pro His Leu Pro Pro Ala Cys Arg Gln Gly 
        35                  40                  45              


Ile Ala Ala Ala Arg Ala Phe Pro Met Gln Gly Val Leu Lys Tyr His 
    50                  55                  60                  


Gly Leu Ser Asp Trp Val Gln Arg Ile Ala Phe Leu Pro Ser Ile Ser 
65                  70                  75                  80  


Ile Asn Asn Ala Ala Ala His Thr Thr Thr Leu Val Glu Phe Asp Pro 
                85                  90                  95      


Ala Leu Pro Ala Asp Ser Ala Val Ile Gly Gly Val Pro Ala His Gly 
            100                 105                 110         


Arg Glu Leu Glu Arg Ile Val His Val Leu Asp Thr Val Arg Ser Leu 
        115                 120                 125             


Ala Gly Ile Thr Ser His Ala Arg Val Val Ser Arg Asn Ile Val Arg 
    130                 135                 140                 


Thr Arg Thr Thr Gly Lys Gly Leu Gly Thr Ser Ala Ser Ala Ala Ala 
145                 150                 155                 160 


Ala Leu Ala Cys Ala Ala Val Gly Ala Ile Phe Gly Pro Glu Leu Ala 
                165                 170                 175     


Gly His Thr Arg Phe Leu Ser Thr Leu Ala Arg Arg Leu Ala Gly Ser 
            180                 185                 190         


Gly Cys Arg Ser Ala Ala Gly Gly Leu Ala Leu Trp Leu Ser Tyr Pro 
        195                 200                 205             


Gly Ile Pro Pro Asp Glu Ser Phe Ala Val Arg Leu Asp Gln Asp His 
    210                 215                 220                 


Glu Leu Asp Asp Leu Ala Leu Ile Thr Val Pro Ile Asp Ser Arg Ile 
225                 230                 235                 240 


Gly Leu Lys Thr Glu Gln Ala His His Asp Ala Pro Gln Ser Ile Phe 
                245                 250                 255     


Phe Arg Ala Trp Met Leu Ala Arg Gly Asp Glu Val Arg Glu Cys Ile 
            260                 265                 270         


Ala Ala Ala Arg Arg Gly Asp Trp Gln Thr Ile Gly Gln Leu Ala Glu 
        275                 280                 285             


Leu Asp Ser Met Arg Leu His Gly Val Thr Met Ser Gly Ser Arg Glu 
    290                 295                 300                 


Gln Lys Ile Ile Gly Trp Glu Pro Glu Asn Ile Thr Leu Phe Arg Leu 
305                 310                 315                 320 


Cys Asn Asp Leu Arg Ala Arg Gly Val Pro Val Tyr Ala Ser Thr Asp 
                325                 330                 335     


Thr Gly Pro Thr Val Val Phe Ile Thr Arg Arg Asp Phe Ala Pro Ile 
            340                 345                 350         


Val Thr Asp Ala Ile His His Ser Gly Leu Asn Val Glu Thr Val Ile 
        355                 360                 365             


Ala Pro Ile Gly Gly Pro Ala His Leu Ile Pro Val Glu Glu Ala Leu 
    370                 375                 380                 


Ala Glu Leu Gln Ser 
385                 


<210>  21
<211>  324
<212>  PRT
<213>  Natronomonas pharaonis

<400>  21

Met Lys Ala Thr Ala Lys Ala His Pro Ile Gln Gly Leu Val Lys Tyr 
1               5                   10                  15      


His Gly Met Arg Asn Glu Glu Leu Arg Leu Pro Tyr His Asp Ser Ile 
            20                  25                  30          


Ser Val Cys Thr Ala Pro Ser His Ser Lys Thr Thr Ala Ala Phe Glu 
        35                  40                  45              


Pro Glu Arg Asp Ala Asp Arg Tyr Val Val Asp Gly Glu Val Val Asp 
    50                  55                  60                  


Gly Arg Gly Ala Glu Arg Ile Arg Ala Val Val Asp His Val Arg Asp 
65                  70                  75                  80  


Val Ala Asp Ile Asp His Arg Val Arg Leu Glu Ser Glu Asn Asp Phe 
                85                  90                  95      


Pro Thr Asn Ile Gly Phe Gly Ser Ser Ser Ser Gly Phe Ala Ala Ala 
            100                 105                 110         


Ala Val Ala Leu Val Glu Ala Ala Gly Leu Glu Leu Ser His Pro Glu 
        115                 120                 125             


Ile Ser Thr Val Ala Arg Arg Gly Ser Ser Ser Ala Ala Arg Ala Val 
    130                 135                 140                 


Thr Gly Ala Phe Ser Gln Leu Tyr Thr Gly Leu Asp Asp Ala Asp Cys 
145                 150                 155                 160 


Tyr Ser Glu Arg Leu Asp Thr Asp Leu Glu Asp Asp Leu Arg Thr Val 
                165                 170                 175     


Ala Ala Glu Ile Pro Ala Phe Lys His Thr Glu Glu Ala His Lys Glu 
            180                 185                 190         


Ala Ala Asp Ser His Met Phe Glu Ala Arg Leu Ala His Ile His Glu 
        195                 200                 205             


Gln Ile Ala Thr Met Arg Asn Ala Leu Arg Glu Asn Asp Phe Asp Arg 
    210                 215                 220                 


Val Phe Glu Leu Ala Glu His Asp Ser Leu Ser Leu Ala Ala Thr Thr 
225                 230                 235                 240 


Met Thr Gly Pro Ala Gly Trp Val Tyr Trp Gln Pro Glu Thr Leu Ser 
                245                 250                 255     


Val Phe Glu Thr Val Arg Thr Leu Arg Glu Asp Asp Asp Ile Pro Val 
            260                 265                 270         


Tyr Phe Ser Thr Asp Thr Gly Ala Ser Val Tyr Val Asn Thr Thr Ala 
        275                 280                 285             


Asp His Val Asp Arg Val Glu Asn Ala Ile Ala Ala Leu Gly Val Asp 
    290                 295                 300                 


Thr Arg Val Trp Glu Val Gly Gly Pro Ala Glu Val Leu Pro Glu Ser 
305                 310                 315                 320 


Glu Ser Leu Phe 
                


<210>  22
<211>  396
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Thr Val Tyr Thr Ala Ser Val Thr Ala Pro Val Asn Ile Ala Thr 
1               5                   10                  15      


Leu Lys Tyr Trp Gly Lys Arg Asp Thr Lys Leu Asn Leu Pro Thr Asn 
            20                  25                  30          


Ser Ser Ile Ser Val Thr Leu Ser Gln Asp Asp Leu Arg Thr Leu Thr 
        35                  40                  45              


Ser Ala Ala Thr Ala Pro Glu Phe Glu Arg Asp Thr Leu Trp Leu Asn 
    50                  55                  60                  


Gly Glu Pro His Ser Ile Asp Asn Glu Arg Thr Gln Asn Cys Leu Arg 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Arg Lys Glu Met Glu Ser Lys Asp Ala Ser Leu 
                85                  90                  95      


Pro Thr Leu Ser Gln Trp Lys Leu His Ile Val Ser Glu Asn Asn Phe 
            100                 105                 110         


Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ala Gly Phe Ala Ala Leu 
        115                 120                 125             


Val Ser Ala Ile Ala Lys Leu Tyr Gln Leu Pro Gln Ser Thr Ser Glu 
    130                 135                 140                 


Ile Ser Arg Ile Ala Arg Lys Gly Ser Gly Ser Ala Cys Arg Ser Leu 
145                 150                 155                 160 


Phe Gly Gly Tyr Val Ala Trp Glu Met Gly Lys Ala Glu Asp Gly His 
                165                 170                 175     


Asp Ser Met Ala Val Gln Ile Ala Asp Ser Ser Asp Trp Pro Gln Met 
            180                 185                 190         


Lys Ala Cys Val Leu Val Val Ser Asp Ile Lys Lys Asp Val Ser Ser 
        195                 200                 205             


Thr Gln Gly Met Gln Leu Thr Val Ala Thr Ser Glu Leu Phe Lys Glu 
    210                 215                 220                 


Arg Ile Glu His Val Val Pro Lys Arg Phe Glu Val Met Arg Lys Ala 
225                 230                 235                 240 


Ile Val Glu Lys Asp Phe Ala Thr Phe Ala Lys Glu Thr Met Met Asp 
                245                 250                 255     


Ser Asn Ser Phe His Ala Thr Cys Leu Asp Ser Phe Pro Pro Ile Phe 
            260                 265                 270         


Tyr Met Asn Asp Thr Ser Lys Arg Ile Ile Ser Trp Cys His Thr Ile 
        275                 280                 285             


Asn Gln Phe Tyr Gly Glu Thr Ile Val Ala Tyr Thr Phe Asp Ala Gly 
    290                 295                 300                 


Pro Asn Ala Val Leu Tyr Tyr Leu Ala Glu Asn Glu Ser Lys Leu Phe 
305                 310                 315                 320 


Ala Phe Ile Tyr Lys Leu Phe Gly Ser Val Pro Gly Trp Asp Lys Lys 
                325                 330                 335     


Phe Thr Thr Glu Gln Leu Glu Ala Phe Asn His Gln Phe Glu Ser Ser 
            340                 345                 350         


Asn Phe Thr Ala Arg Glu Leu Asp Leu Glu Leu Gln Lys Asp Val Ala 
        355                 360                 365             


Arg Val Ile Leu Thr Gln Val Gly Ser Gly Pro Gln Glu Thr Asn Glu 
    370                 375                 380                 


Ser Leu Ile Asp Ala Lys Thr Gly Leu Pro Lys Glu 
385                 390                 395     


