                               SEQUENCE LISTING

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> METHODS FOR REGULATING HAIR GROWTH DISORDERS

<130> 070050.4924

<140> PCT/US2013/034683
<141> 2013-03-29

<150> 61/617,363
<151> 2012-03-29

<160> 55    

<170> PatentIn version 3.5

<210> 1
<211> 245
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 2
<211> 2705
<212> DNA
<213> Homo sapiens

<400> 2
gtgccgcgcc cagagcagca gcaacagcga agatgcgagg ccattacctg tttgatccct       60

gtcggaaacc tggcacgggc caacttttcc cgattatcac gccaagaagt tgcaaggact      120

agtcgaagac tcggaggggc cagggcgagg gcgcgctccc ccgcgcgctg cctcgtccct      180

cctccgtccg gccgcccgag ctcccggcct ctctcccgcc cgcgctcact ccctccgccc      240

gcctccctcc tctggccccc atcagaaggg caacagggcg agggggtccg gcgaaattcg      300

gaccggagca gctggacatg cacggtgtcc gccgggcgca ggggccgacc acacgcagtc      360

gcgcagttca gcatccgcgt gccagtctcg cccgcgatcc cgggcccggg gctgtggcgt      420

cgactccgac ccaggcagcc agcagcccgc gcgggagccg gaccgccgcc ggaggagctc      480

ggacggcatg ctgagccccc tccttggctg aagcccgagt gcggagaagc ccgggcaaac      540

gcaggctaag gagaccaaag cggcgaagtc gcgagacagc ggacaagcag cggaggagaa      600

ggaggaggag gcgaacccag agaggggcag caaaagaagc ggtggtggtg ggcgtcgtgg      660

ccatggcggc ggctatcgcc agctcgctca tccgtcagaa gaggcaagcc cgcgagcgcg      720

agaaatccaa cgcctgcaag tgtgtcagca gccccagcaa aggcaagacc agctgcgaca      780

aaaacaagtt aaatgtcttt tcccgggtca aactcttcgg ctccaagaag aggcgcagaa      840

gaagaccaga gcctcagctt aagggtatag ttaccaagct atacagccga caaggctacc      900

acttgcagct gcaggcggat ggaaccattg atggcaccaa agatgaggac agcacttaca      960

ctctgtttaa cctcatccct gtgggtctgc gagtggtggc tatccaagga gttcaaacca     1020

agctgtactt ggcaatgaac agtgagggat acttgtacac ctcggaactt ttcacacctg     1080

agtgcaaatt caaagaatca gtgtttgaaa attattatgt gacatattca tcaatgatat     1140

accgtcagca gcagtcaggc cgagggtggt atctgggtct gaacaaagaa ggagagatca     1200

tgaaaggcaa ccatgtgaag aagaacaagc ctgcagctca ttttctgcct aaaccactga     1260

aagtggccat gtacaaggag ccatcactgc acgatctcac ggagttctcc cgatctggaa     1320

gcgggacccc aaccaagagc agaagtgtct ctggcgtgct gaacggaggc aaatccatga     1380

gccacaatga atcaacgtag ccagtgaggg caaaagaagg gctctgtaac agaaccttac     1440

ctccaggtgc tgttgaattc ttctagcagt ccttcaccca aaagttcaaa tttgtcagtg     1500

acatttacca aacaaacagg cagagttcac tattctatct gccattagac cttcttatca     1560

tccatactaa agccccatta tttagattga gcttgtgcat aagaatgcca agcattttag     1620

tgaactaaat ctgagagaag gactgccaaa ttttctcatg atctcaccta tactttgggg     1680

atgataatcc aaaagtattt cacagcacta atgctgatca aaatttgctc tcccaccaag     1740

aaaatgtaaa agaccacaat tgttcttcaa aaacaaacaa aacaaaacaa aacaaaatta     1800

actgcttaaa tgttttgtcg gggcaaacaa aattatgtga attgtgttgt tttcttggct     1860

tgatgttttc tatctacgct tgattcacat gtactctttt ctttggcata gtgcaacttt     1920

atgatttctg aaattcaatg gttctattga ctttttgcgt cacttaatcc aaatcaacca     1980

aattcagggt tgaatctgaa ttggcttctc aggctcaagg taacagtgtt cttgtggttt     2040

gaccaattgt ttttctttct tttttttttt ttttagattt gtggtattct ggtcaagtta     2100

ttgtgctgta ctttgtgcgt agaaattgag ttgtattgtc aaccccagtc agtaaagaga     2160

acttcaaaaa attatcctca agtgtagatt tctcttaatt ccatttgtgt atcatgttaa     2220

actattgttg tggcttcttg tgtaaagaca ggaactgtgg aactgtgatg ttgtcttttg     2280

tgttgttaaa ataagaaatg tcttatctgt atatgtatga gtcttcctgt cattgtattt     2340

ggcacatgaa tattgtgtac aaggaattgt taagactggt tttccctcaa caacatatat     2400

tatacttgct actggaaaag tgtttaagac ttagctaggt ttccatttag atcttcatat     2460

ctgttgcatg gaagaaagtt gggttcttgg catagagttg catgatatgt aagattttgt     2520

gcattcataa ttgttaaaaa tctgtgttcc aaaagtggac atagcatgta caggcagttt     2580

tctgtcctgt gcacaaaaag tttaaaaaag ttgtttaata tttgttgttg tatacccaaa     2640

tacgcaccga ataaactctt tatattcatt caaagaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaa                                                                 2705


<210> 3
<211> 255
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Gly Lys Val Thr Lys Pro Lys Glu Glu Lys Asp Ala Ser Lys 
1               5                   10                  15      


Val Leu Asp Asp Ala Pro Pro Gly Thr Gln Glu Tyr Ile Met Leu Arg 
            20                  25                  30          


Gln Asp Ser Ile Gln Ser Ala Glu Leu Lys Lys Lys Glu Ser Pro Phe 
        35                  40                  45              


Arg Ala Lys Cys His Glu Ile Phe Cys Cys Pro Leu Lys Gln Val His 
    50                  55                  60                  


His Lys Glu Asn Thr Glu Pro Glu Glu Pro Gln Leu Lys Gly Ile Val 
65                  70                  75                  80  


Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His Leu Gln Leu Gln Ala Asp 
                85                  90                  95      


Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp Ser Thr Tyr Thr Leu Phe 
            100                 105                 110         


Asn Leu Ile Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Gln 
        115                 120                 125             


Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu Gly Tyr Leu Tyr Thr Ser 
    130                 135                 140                 


Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn 
145                 150                 155                 160 


Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr Arg Gln Gln Gln Ser Gly 
                165                 170                 175     


Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu Gly Glu Ile Met Lys Gly 
            180                 185                 190         


Asn His Val Lys Lys Asn Lys Pro Ala Ala His Phe Leu Pro Lys Pro 
        195                 200                 205             


Leu Lys Val Ala Met Tyr Lys Glu Pro Ser Leu His Asp Leu Thr Glu 
    210                 215                 220                 


Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr Lys Ser Arg Ser Val Ser 
225                 230                 235                 240 


Gly Val Leu Asn Gly Gly Lys Ser Met Ser His Asn Glu Ser Thr 
                245                 250                 255 


<210> 4
<211> 2340
<212> DNA
<213> Homo sapiens

<400> 4
gtggctctct aggaccggag agttctttgg aaggagagcg cgagcgaggg agcgggcgag       60

ctccgagggg gtgtgggtgt agggagagag agaaagagag caggcagcgg cggcggcggc      120

agcggtgggg aaaagcggat tccgccccga accacaccga ggggagctcg tggtcgagac      180

ttgccgccct aagcactctc ccaagtccga cccgctcggc gaggacttcc gtcttctgag      240

cgaaccttgt caagcaagct gggatctatg agtggaaagg tgaccaagcc caaagaggag      300

aaagatgctt ctaaggttct ggatgacgcc ccccctggca cacaggaata cattatgtta      360

cgacaagatt ccatccaatc tgcggaatta aagaaaaaag agtccccctt tcgtgctaag      420

tgtcacgaaa tcttctgctg cccgctgaag caagtacacc acaaagagaa cacagagccg      480

gaagagcctc agcttaaggg tatagttacc aagctataca gccgacaagg ctaccacttg      540

cagctgcagg cggatggaac cattgatggc accaaagatg aggacagcac ttacactctg      600

tttaacctca tccctgtggg tctgcgagtg gtggctatcc aaggagttca aaccaagctg      660

tacttggcaa tgaacagtga gggatacttg tacacctcgg aacttttcac acctgagtgc      720

aaattcaaag aatcagtgtt tgaaaattat tatgtgacat attcatcaat gatataccgt      780

cagcagcagt caggccgagg gtggtatctg ggtctgaaca aagaaggaga gatcatgaaa      840

ggcaaccatg tgaagaagaa caagcctgca gctcattttc tgcctaaacc actgaaagtg      900

gccatgtaca aggagccatc actgcacgat ctcacggagt tctcccgatc tggaagcggg      960

accccaacca agagcagaag tgtctctggc gtgctgaacg gaggcaaatc catgagccac     1020

aatgaatcaa cgtagccagt gagggcaaaa gaagggctct gtaacagaac cttacctcca     1080

ggtgctgttg aattcttcta gcagtccttc acccaaaagt tcaaatttgt cagtgacatt     1140

taccaaacaa acaggcagag ttcactattc tatctgccat tagaccttct tatcatccat     1200

actaaagccc cattatttag attgagcttg tgcataagaa tgccaagcat tttagtgaac     1260

taaatctgag agaaggactg ccaaattttc tcatgatctc acctatactt tggggatgat     1320

aatccaaaag tatttcacag cactaatgct gatcaaaatt tgctctccca ccaagaaaat     1380

gtaaaagacc acaattgttc ttcaaaaaca aacaaaacaa aacaaaacaa aattaactgc     1440

ttaaatgttt tgtcggggca aacaaaatta tgtgaattgt gttgttttct tggcttgatg     1500

ttttctatct acgcttgatt cacatgtact cttttctttg gcatagtgca actttatgat     1560

ttctgaaatt caatggttct attgactttt tgcgtcactt aatccaaatc aaccaaattc     1620

agggttgaat ctgaattggc ttctcaggct caaggtaaca gtgttcttgt ggtttgacca     1680

attgtttttc tttctttttt ttttttttta gatttgtggt attctggtca agttattgtg     1740

ctgtactttg tgcgtagaaa ttgagttgta ttgtcaaccc cagtcagtaa agagaacttc     1800

aaaaaattat cctcaagtgt agatttctct taattccatt tgtgtatcat gttaaactat     1860

tgttgtggct tcttgtgtaa agacaggaac tgtggaactg tgatgttgtc ttttgtgttg     1920

ttaaaataag aaatgtctta tctgtatatg tatgagtctt cctgtcattg tatttggcac     1980

atgaatattg tgtacaagga attgttaaga ctggttttcc ctcaacaaca tatattatac     2040

ttgctactgg aaaagtgttt aagacttagc taggtttcca tttagatctt catatctgtt     2100

gcatggaaga aagttgggtt cttggcatag agttgcatga tatgtaagat tttgtgcatt     2160

cataattgtt aaaaatctgt gttccaaaag tggacatagc atgtacaggc agttttctgt     2220

cctgtgcaca aaaagtttaa aaaagttgtt taatatttgt tgttgtatac ccaaatacgc     2280

accgaataaa ctctttatat tcattcaaag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340


<210> 5
<211> 226
<212> PRT
<213> Homo sapiens

<400> 5
Met Leu Arg Gln Asp Ser Ile Gln Ser Ala Glu Leu Lys Lys Lys Glu 
1               5                   10                  15      


Ser Pro Phe Arg Ala Lys Cys His Glu Ile Phe Cys Cys Pro Leu Lys 
            20                  25                  30          


Gln Val His His Lys Glu Asn Thr Glu Pro Glu Glu Pro Gln Leu Lys 
        35                  40                  45              


Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His Leu Gln Leu 
    50                  55                  60                  


Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp Ser Thr Tyr 
65                  70                  75                  80  


Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val Ala Ile Gln 
                85                  90                  95      


Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu Gly Tyr Leu 
            100                 105                 110         


Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys Glu Ser Val 
        115                 120                 125             


Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr Arg Gln Gln 
    130                 135                 140                 


Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu Gly Glu Ile 
145                 150                 155                 160 


Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala His Phe Leu 
                165                 170                 175     


Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser Leu His Asp 
            180                 185                 190         


Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr Lys Ser Arg 
        195                 200                 205             


Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser His Asn Glu 
    210                 215                 220                 


Ser Thr 
225     


<210> 6
<211> 2450
<212> DNA
<213> Homo sapiens

<400> 6
gtggctctct aggaccggag agttctttgg aaggagagcg cgagcgaggg agcgggcgag       60

ctccgagggg gtgtgggtgt agggagagag agaaagagag caggcagcgg cggcggcggc      120

agcggtgggg aaaagcggat tccgccccga accacaccga ggggagctcg tggtcgagac      180

ttgccgccct aagcactctc ccaagtccga cccgctcggc gaggacttcc gtcttctgag      240

cgaaccttgt caagcaagct gggatctatg agtggaaagg tgaccaagcc caaagaggag      300

aaagatgctt ctaagggagt ttctctgcac aagctctctg tttgcctgct gtcgtccaca      360

taagatgtga cttgctcctg cttgccttcc tccatgattg tgaggcctcc ccagccacgt      420

ggaactttct ggatgacgcc ccccctggca cacaggaata cattatgtta cgacaagatt      480

ccatccaatc tgcggaatta aagaaaaaag agtccccctt tcgtgctaag tgtcacgaaa      540

tcttctgctg cccgctgaag caagtacacc acaaagagaa cacagagccg gaagagcctc      600

agcttaaggg tatagttacc aagctataca gccgacaagg ctaccacttg cagctgcagg      660

cggatggaac cattgatggc accaaagatg aggacagcac ttacactctg tttaacctca      720

tccctgtggg tctgcgagtg gtggctatcc aaggagttca aaccaagctg tacttggcaa      780

tgaacagtga gggatacttg tacacctcgg aacttttcac acctgagtgc aaattcaaag      840

aatcagtgtt tgaaaattat tatgtgacat attcatcaat gatataccgt cagcagcagt      900

caggccgagg gtggtatctg ggtctgaaca aagaaggaga gatcatgaaa ggcaaccatg      960

tgaagaagaa caagcctgca gctcattttc tgcctaaacc actgaaagtg gccatgtaca     1020

aggagccatc actgcacgat ctcacggagt tctcccgatc tggaagcggg accccaacca     1080

agagcagaag tgtctctggc gtgctgaacg gaggcaaatc catgagccac aatgaatcaa     1140

cgtagccagt gagggcaaaa gaagggctct gtaacagaac cttacctcca ggtgctgttg     1200

aattcttcta gcagtccttc acccaaaagt tcaaatttgt cagtgacatt taccaaacaa     1260

acaggcagag ttcactattc tatctgccat tagaccttct tatcatccat actaaagccc     1320

cattatttag attgagcttg tgcataagaa tgccaagcat tttagtgaac taaatctgag     1380

agaaggactg ccaaattttc tcatgatctc acctatactt tggggatgat aatccaaaag     1440

tatttcacag cactaatgct gatcaaaatt tgctctccca ccaagaaaat gtaaaagacc     1500

acaattgttc ttcaaaaaca aacaaaacaa aacaaaacaa aattaactgc ttaaatgttt     1560

tgtcggggca aacaaaatta tgtgaattgt gttgttttct tggcttgatg ttttctatct     1620

acgcttgatt cacatgtact cttttctttg gcatagtgca actttatgat ttctgaaatt     1680

caatggttct attgactttt tgcgtcactt aatccaaatc aaccaaattc agggttgaat     1740

ctgaattggc ttctcaggct caaggtaaca gtgttcttgt ggtttgacca attgtttttc     1800

tttctttttt ttttttttta gatttgtggt attctggtca agttattgtg ctgtactttg     1860

tgcgtagaaa ttgagttgta ttgtcaaccc cagtcagtaa agagaacttc aaaaaattat     1920

cctcaagtgt agatttctct taattccatt tgtgtatcat gttaaactat tgttgtggct     1980

tcttgtgtaa agacaggaac tgtggaactg tgatgttgtc ttttgtgttg ttaaaataag     2040

aaatgtctta tctgtatatg tatgagtctt cctgtcattg tatttggcac atgaatattg     2100

tgtacaagga attgttaaga ctggttttcc ctcaacaaca tatattatac ttgctactgg     2160

aaaagtgttt aagacttagc taggtttcca tttagatctt catatctgtt gcatggaaga     2220

aagttgggtt cttggcatag agttgcatga tatgtaagat tttgtgcatt cataattgtt     2280

aaaaatctgt gttccaaaag tggacatagc atgtacaggc agttttctgt cctgtgcaca     2340

aaaagtttaa aaaagttgtt taatatttgt tgttgtatac ccaaatacgc accgaataaa     2400

ctctttatat tcattcaaag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2450


<210> 7
<211> 199
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Gly Lys Val Thr Lys Pro Lys Glu Glu Lys Asp Ala Ser Lys 
1               5                   10                  15      


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly 
            20                  25                  30          


Tyr His Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp 
        35                  40                  45              


Glu Asp Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
    50                  55                  60                  


Val Val Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn 
65                  70                  75                  80  


Ser Glu Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys 
                85                  90                  95      


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met 
            100                 105                 110         


Ile Tyr Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn 
        115                 120                 125             


Lys Glu Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro 
    130                 135                 140                 


Ala Ala His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu 
145                 150                 155                 160 


Pro Ser Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr 
                165                 170                 175     


Pro Thr Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser 
            180                 185                 190         


Met Ser His Asn Glu Ser Thr 
        195                 


<210> 8
<211> 2172
<212> DNA
<213> Homo sapiens

<400> 8
gtggctctct aggaccggag agttctttgg aaggagagcg cgagcgaggg agcgggcgag       60

ctccgagggg gtgtgggtgt agggagagag agaaagagag caggcagcgg cggcggcggc      120

agcggtgggg aaaagcggat tccgccccga accacaccga ggggagctcg tggtcgagac      180

ttgccgccct aagcactctc ccaagtccga cccgctcggc gaggacttcc gtcttctgag      240

cgaaccttgt caagcaagct gggatctatg agtggaaagg tgaccaagcc caaagaggag      300

aaagatgctt ctaaggagcc tcagcttaag ggtatagtta ccaagctata cagccgacaa      360

ggctaccact tgcagctgca ggcggatgga accattgatg gcaccaaaga tgaggacagc      420

acttacactc tgtttaacct catccctgtg ggtctgcgag tggtggctat ccaaggagtt      480

caaaccaagc tgtacttggc aatgaacagt gagggatact tgtacacctc ggaacttttc      540

acacctgagt gcaaattcaa agaatcagtg tttgaaaatt attatgtgac atattcatca      600

atgatatacc gtcagcagca gtcaggccga gggtggtatc tgggtctgaa caaagaagga      660

gagatcatga aaggcaacca tgtgaagaag aacaagcctg cagctcattt tctgcctaaa      720

ccactgaaag tggccatgta caaggagcca tcactgcacg atctcacgga gttctcccga      780

tctggaagcg ggaccccaac caagagcaga agtgtctctg gcgtgctgaa cggaggcaaa      840

tccatgagcc acaatgaatc aacgtagcca gtgagggcaa aagaagggct ctgtaacaga      900

accttacctc caggtgctgt tgaattcttc tagcagtcct tcacccaaaa gttcaaattt      960

gtcagtgaca tttaccaaac aaacaggcag agttcactat tctatctgcc attagacctt     1020

cttatcatcc atactaaagc cccattattt agattgagct tgtgcataag aatgccaagc     1080

attttagtga actaaatctg agagaaggac tgccaaattt tctcatgatc tcacctatac     1140

tttggggatg ataatccaaa agtatttcac agcactaatg ctgatcaaaa tttgctctcc     1200

caccaagaaa atgtaaaaga ccacaattgt tcttcaaaaa caaacaaaac aaaacaaaac     1260

aaaattaact gcttaaatgt tttgtcgggg caaacaaaat tatgtgaatt gtgttgtttt     1320

cttggcttga tgttttctat ctacgcttga ttcacatgta ctcttttctt tggcatagtg     1380

caactttatg atttctgaaa ttcaatggtt ctattgactt tttgcgtcac ttaatccaaa     1440

tcaaccaaat tcagggttga atctgaattg gcttctcagg ctcaaggtaa cagtgttctt     1500

gtggtttgac caattgtttt tctttctttt tttttttttt tagatttgtg gtattctggt     1560

caagttattg tgctgtactt tgtgcgtaga aattgagttg tattgtcaac cccagtcagt     1620

aaagagaact tcaaaaaatt atcctcaagt gtagatttct cttaattcca tttgtgtatc     1680

atgttaaact attgttgtgg cttcttgtgt aaagacagga actgtggaac tgtgatgttg     1740

tcttttgtgt tgttaaaata agaaatgtct tatctgtata tgtatgagtc ttcctgtcat     1800

tgtatttggc acatgaatat tgtgtacaag gaattgttaa gactggtttt ccctcaacaa     1860

catatattat acttgctact ggaaaagtgt ttaagactta gctaggtttc catttagatc     1920

ttcatatctg ttgcatggaa gaaagttggg ttcttggcat agagttgcat gatatgtaag     1980

attttgtgca ttcataattg ttaaaaatct gtgttccaaa agtggacata gcatgtacag     2040

gcagttttct gtcctgtgca caaaaagttt aaaaaagttg tttaatattt gttgttgtat     2100

acccaaatac gcaccgaata aactctttat attcattcaa agaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aa                                                         2172


<210> 9
<211> 226
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Arg Gln Asp Ser Ile Gln Ser Ala Glu Leu Lys Lys Lys Glu 
1               5                   10                  15      


Ser Pro Phe Arg Ala Lys Cys His Glu Ile Phe Cys Cys Pro Leu Lys 
            20                  25                  30          


Gln Val His His Lys Glu Asn Thr Glu Pro Glu Glu Pro Gln Leu Lys 
        35                  40                  45              


Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His Leu Gln Leu 
    50                  55                  60                  


Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp Ser Thr Tyr 
65                  70                  75                  80  


Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val Ala Ile Gln 
                85                  90                  95      


Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu Gly Tyr Leu 
            100                 105                 110         


Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys Glu Ser Val 
        115                 120                 125             


Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr Arg Gln Gln 
    130                 135                 140                 


Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu Gly Glu Ile 
145                 150                 155                 160 


Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala His Phe Leu 
                165                 170                 175     


Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser Leu His Asp 
            180                 185                 190         


Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr Lys Ser Arg 
        195                 200                 205             


Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser His Asn Glu 
    210                 215                 220                 


Ser Thr 
225     


<210> 10
<211> 2093
<212> DNA
<213> Homo sapiens

<400> 10
catgtaacat gtgatttgct cctccttgcc ttccaccgtg atgtgaggcc tccccaacca       60

agtggaactt tctggatgac gccccccctg gcacacagga atacattatg ttacgacaag      120

attccatcca atctgcggaa ttaaagaaaa aagagtcccc ctttcgtgct aagtgtcacg      180

aaatcttctg ctgcccgctg aagcaagtac accacaaaga gaacacagag ccggaagagc      240

ctcagcttaa gggtatagtt accaagctat acagccgaca aggctaccac ttgcagctgc      300

aggcggatgg aaccattgat ggcaccaaag atgaggacag cacttacact ctgtttaacc      360

tcatccctgt gggtctgcga gtggtggcta tccaaggagt tcaaaccaag ctgtacttgg      420

caatgaacag tgagggatac ttgtacacct cggaactttt cacacctgag tgcaaattca      480

aagaatcagt gtttgaaaat tattatgtga catattcatc aatgatatac cgtcagcagc      540

agtcaggccg agggtggtat ctgggtctga acaaagaagg agagatcatg aaaggcaacc      600

atgtgaagaa gaacaagcct gcagctcatt ttctgcctaa accactgaaa gtggccatgt      660

acaaggagcc atcactgcac gatctcacgg agttctcccg atctggaagc gggaccccaa      720

ccaagagcag aagtgtctct ggcgtgctga acggaggcaa atccatgagc cacaatgaat      780

caacgtagcc agtgagggca aaagaagggc tctgtaacag aaccttacct ccaggtgctg      840

ttgaattctt ctagcagtcc ttcacccaaa agttcaaatt tgtcagtgac atttaccaaa      900

caaacaggca gagttcacta ttctatctgc cattagacct tcttatcatc catactaaag      960

ccccattatt tagattgagc ttgtgcataa gaatgccaag cattttagtg aactaaatct     1020

gagagaagga ctgccaaatt ttctcatgat ctcacctata ctttggggat gataatccaa     1080

aagtatttca cagcactaat gctgatcaaa atttgctctc ccaccaagaa aatgtaaaag     1140

accacaattg ttcttcaaaa acaaacaaaa caaaacaaaa caaaattaac tgcttaaatg     1200

ttttgtcggg gcaaacaaaa ttatgtgaat tgtgttgttt tcttggcttg atgttttcta     1260

tctacgcttg attcacatgt actcttttct ttggcatagt gcaactttat gatttctgaa     1320

attcaatggt tctattgact ttttgcgtca cttaatccaa atcaaccaaa ttcagggttg     1380

aatctgaatt ggcttctcag gctcaaggta acagtgttct tgtggtttga ccaattgttt     1440

ttctttcttt tttttttttt ttagatttgt ggtattctgg tcaagttatt gtgctgtact     1500

ttgtgcgtag aaattgagtt gtattgtcaa ccccagtcag taaagagaac ttcaaaaaat     1560

tatcctcaag tgtagatttc tcttaattcc atttgtgtat catgttaaac tattgttgtg     1620

gcttcttgtg taaagacagg aactgtggaa ctgtgatgtt gtcttttgtg ttgttaaaat     1680

aagaaatgtc ttatctgtat atgtatgagt cttcctgtca ttgtatttgg cacatgaata     1740

ttgtgtacaa ggaattgtta agactggttt tccctcaaca acatatatta tacttgctac     1800

tggaaaagtg tttaagactt agctaggttt ccatttagat cttcatatct gttgcatgga     1860

agaaagttgg gttcttggca tagagttgca tgatatgtaa gattttgtgc attcataatt     1920

gttaaaaatc tgtgttccaa aagtggacat agcatgtaca ggcagttttc tgtcctgtgc     1980

acaaaaagtt taaaaaagtt gtttaatatt tgttgttgta tacccaaata cgcaccgaat     2040

aaactcttta tattcattca aagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            2093


<210> 11
<211> 192
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Leu Leu Arg Lys Ser Tyr Ser Glu Pro Gln Leu Lys Gly Ile 
1               5                   10                  15      


Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His Leu Gln Leu Gln Ala 
            20                  25                  30          


Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp Ser Thr Tyr Thr Leu 
        35                  40                  45              


Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val 
    50                  55                  60                  


Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu Gly Tyr Leu Tyr Thr 
65                  70                  75                  80  


Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu 
                85                  90                  95      


Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr Arg Gln Gln Gln Ser 
            100                 105                 110         


Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu Gly Glu Ile Met Lys 
        115                 120                 125             


Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala His Phe Leu Pro Lys 
    130                 135                 140                 


Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser Leu His Asp Leu Thr 
145                 150                 155                 160 


Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr Lys Ser Arg Ser Val 
                165                 170                 175     


Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser His Asn Glu Ser Thr 
            180                 185                 190         


<210> 12
<211> 1968
<212> DNA
<213> Homo sapiens

<400> 12
aaactttctc tgatctcctc tctctctgtg tctgctccaa atgtagacag caattgtctg       60

ggtaggacca gcttataaag aagcatggct ttgttaagga agtcgtattc agagcctcag      120

cttaagggta tagttaccaa gctatacagc cgacaaggct accacttgca gctgcaggcg      180

gatggaacca ttgatggcac caaagatgag gacagcactt acactctgtt taacctcatc      240

cctgtgggtc tgcgagtggt ggctatccaa ggagttcaaa ccaagctgta cttggcaatg      300

aacagtgagg gatacttgta cacctcggaa cttttcacac ctgagtgcaa attcaaagaa      360

tcagtgtttg aaaattatta tgtgacatat tcatcaatga tataccgtca gcagcagtca      420

ggccgagggt ggtatctggg tctgaacaaa gaaggagaga tcatgaaagg caaccatgtg      480

aagaagaaca agcctgcagc tcattttctg cctaaaccac tgaaagtggc catgtacaag      540

gagccatcac tgcacgatct cacggagttc tcccgatctg gaagcgggac cccaaccaag      600

agcagaagtg tctctggcgt gctgaacgga ggcaaatcca tgagccacaa tgaatcaacg      660

tagccagtga gggcaaaaga agggctctgt aacagaacct tacctccagg tgctgttgaa      720

ttcttctagc agtccttcac ccaaaagttc aaatttgtca gtgacattta ccaaacaaac      780

aggcagagtt cactattcta tctgccatta gaccttctta tcatccatac taaagcccca      840

ttatttagat tgagcttgtg cataagaatg ccaagcattt tagtgaacta aatctgagag      900

aaggactgcc aaattttctc atgatctcac ctatactttg gggatgataa tccaaaagta      960

tttcacagca ctaatgctga tcaaaatttg ctctcccacc aagaaaatgt aaaagaccac     1020

aattgttctt caaaaacaaa caaaacaaaa caaaacaaaa ttaactgctt aaatgttttg     1080

tcggggcaaa caaaattatg tgaattgtgt tgttttcttg gcttgatgtt ttctatctac     1140

gcttgattca catgtactct tttctttggc atagtgcaac tttatgattt ctgaaattca     1200

atggttctat tgactttttg cgtcacttaa tccaaatcaa ccaaattcag ggttgaatct     1260

gaattggctt ctcaggctca aggtaacagt gttcttgtgg tttgaccaat tgtttttctt     1320

tctttttttt tttttttaga tttgtggtat tctggtcaag ttattgtgct gtactttgtg     1380

cgtagaaatt gagttgtatt gtcaacccca gtcagtaaag agaacttcaa aaaattatcc     1440

tcaagtgtag atttctctta attccatttg tgtatcatgt taaactattg ttgtggcttc     1500

ttgtgtaaag acaggaactg tggaactgtg atgttgtctt ttgtgttgtt aaaataagaa     1560

atgtcttatc tgtatatgta tgagtcttcc tgtcattgta tttggcacat gaatattgtg     1620

tacaaggaat tgttaagact ggttttccct caacaacata tattatactt gctactggaa     1680

aagtgtttaa gacttagcta ggtttccatt tagatcttca tatctgttgc atggaagaaa     1740

gttgggttct tggcatagag ttgcatgata tgtaagattt tgtgcattca taattgttaa     1800

aaatctgtgt tccaaaagtg gacatagcat gtacaggcag ttttctgtcc tgtgcacaaa     1860

aagtttaaaa aagttgttta atatttgttg ttgtataccc aaatacgcac cgaataaact     1920

ctttatattc attcaaagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  1968


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gaacaaagaa ggagagatc                                                    19


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
cagcttaagg gtatagtta                                                    19


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
acaaagaagg agagatcat                                                    19


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gcaaccatgt gaagaagaa                                                    19


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gaacaagcct gcagctcat                                                    19


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gcacttacac tctgtttaa                                                    19


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gagagatcat gaaaggcaa                                                    19


<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
tgaaagtggc catgtacaa                                                    19


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
caccaccacc gcttcttttg ctgc                                              24


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tggcattaca agagttagct tctga                                             25


<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
aatgctttgt agtggctttg tttcc                                             25


<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tggcattaca agagttagct tctga                                             25


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cctccagggt gactaaattt g                                                 21


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
aactagaagg ccattggctg                                                   20


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
aatgctttgt agtggctttg tttcc                                             25


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
cagccgacaa ggctaccac                                                    19


<210> 29
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gttccgaggt gtacaagtat cc                                                22


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
gcagcaggaa cttttgacag                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
gctggtgtgt tccaattcag                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gttgggacgc cttgtttagc                                                   20


<210> 33
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
tagcgcgaag aaatatcaaa cag                                               23


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
gcattctgtg gaggctctat c                                                 21


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gctgcattgt agttgtggtg                                                   20


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ggacatttct ggctgccttt g                                                 21


<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
ccagaatcgg gtatccaag                                                    19


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
gggatcttcc agtgggatct                                                   20


<210> 39
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
gcagtcatcc agagatgtga cc                                                22


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
atggacacgc tcccctgact                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
gaaaggtggg agcctcagtc                                                   20


<210> 42
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
cgagaaatcc aacgcctgc                                                    19


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
caccactcgc agacccacag                                                   20


<210> 44
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
gttaaggaag tcgtattcag agc                                               23


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
caccactcgc agacccacag                                                   20


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
gatgcttcta aggagcctca g                                                 21


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
caccactcgc agacccacag                                                   20


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
acagagccgg aagagcctca g                                                 21


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
caccactcgc agacccacag                                                   20


<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
gatgcttcta aggttctgga t                                                 21


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
caccactcgc agacccacag                                                   20


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
tcaaaccaag ctgtatttgg c                                                 21


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
ctttcagtgg tttgggcaga a                                                 21


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
agcctcagct taagggtata g                                                 21


<210> 55
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
caagaacact gttaccttga gc                                                22


