                         SEQUENCE LISTING

<110>  RAO, DONALD
       WANG, ZHAOHUI
       NEMUNAITIS, JOHN J.
       SENZER, NEIL
       O'MALLEY, BERT W.
       LONARD, DAVID
 
<120>  METHODS AND COMPOSITIONS TO TREAT CANCER USING BIFUNCTIONAL SRC-3
        shRNA

<130>  GRAD:1036

<140>  UNKNOWN
<141>  2013-03-21

<150>  61/616,873
<151>  2012-03-28

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  7996
<212>  DNA
<213>  Homo sapiens

<400>  1
atatcccagt ggcccccgtg cggcgacttt agctgctgct gtctcagccg ctccacagcg       60

acggcggcgg ctgcggctta gtcggtggcg gccggcggcg gctgcgggct gagcggcgag      120

tttccgattt aaagctgagc tgcgaggaaa atggcggcgg gaggatcaaa atacttgctg      180

gatggtggac tcagagacca ataaaaataa actgcttgaa catcctttga ctggttagcc      240

agttgctgat gtatattcaa gatgagtgga ttaggagaaa acttggatcc actggccagt      300

gattcacgaa aacgcaaatt gccatgtgat actccaggac aaggtcttac ctgcagtggt      360

gaaaaacgga gacgggagca ggaaagtaaa tatattgaag aattggctga gctgatatct      420

gccaatctta gtgatattga caatttcaat gtcaaaccag ataaatgtgc gattttaaag      480

gaaacagtaa gacagatacg tcaaataaaa gagcaaggaa aaactatttc caatgatgat      540

gatgttcaaa aagccgatgt atcttctaca gggcagggag ttattgataa agactcctta      600

ggaccgcttt tacttcaggc attggatggt ttcctatttg tggtgaatcg agacggaaac      660

attgtatttg tatcagaaaa tgtcacacaa tacctgcaat ataagcaaga ggacctggtt      720

aacacaagtg tttacaatat cttacatgaa gaagacagaa aggattttct taagaattta      780

ccaaaatcta cagttaatgg agtttcctgg acaaatgaga cccaaagaca aaaaagccat      840

acatttaatt gccgtatgtt gatgaaaaca ccacatgata ttctggaaga cataaacgcc      900

agtcctgaaa tgcgccagag atatgaaaca atgcagtgct ttgccctgtc tcagccacga      960

gctatgatgg aggaagggga agatttgcaa tcttgtatga tctgtgtggc acgccgcatt     1020

actacaggag aaagaacatt tccatcaaac cctgagagct ttattaccag acatgatctt     1080

tcaggaaagg ttgtcaatat agatacaaat tcactgagat cctccatgag gcctggcttt     1140

gaagatataa tccgaaggtg tattcagaga ttttttagtc taaatgatgg gcagtcatgg     1200

tcccagaaac gtcactatca agaagcttat cttaatggcc atgcagaaac cccagtatat     1260

cgattctcgt tggctgatgg aactatagtg actgcacaga caaaaagcaa actcttccga     1320

aatcctgtaa caaatgatcg acatggcttt gtctcaaccc acttccttca gagagaacag     1380

aatggatata gaccaaaccc aaatcctgtt ggacaaggga ttagaccacc tatggctgga     1440

tgcaacagtt cggtaggcgg catgagtatg tcgccaaacc aaggcttaca gatgccgagc     1500

agcagggcct atggcttggc agaccctagc accacagggc agatgagtgg agctaggtat     1560

gggggttcca gtaacatagc ttcattgacc cctgggccag gcatgcaatc accatcttcc     1620

taccagaaca acaactatgg gctcaacatg agtagccccc cacatgggag tcctggtctt     1680

gccccaaacc agcagaatat catgatttct cctcgtaatc gtgggagtcc aaagatagcc     1740

tcacatcagt tttctcctgt tgcaggtgtg cactctccca tggcatcttc tggcaatact     1800

gggaaccaca gcttttccag cagctctctc agtgccctgc aagccatcag tgaaggtgtg     1860

gggacttccc ttttatctac tctgtcatca ccaggcccca aattggataa ctctcccaat     1920

atgaatatta cccaaccaag taaagtaagc aatcaggatt ccaagagtcc tctgggcttt     1980

tattgcgacc aaaatccagt ggagagttca atgtgtcagt caaatagcag agatcacctc     2040

agtgacaaag aaagtaagga gagcagtgtt gagggggcag agaatcaaag gggtcctttg     2100

gaaagcaaag gtcataaaaa attactgcag ttacttacct gttcttctga tgaccggggt     2160

cattcctcct tgaccaactc ccccctagat tcaagttgta aagaatcttc tgttagtgtc     2220

accagcccct ctggagtctc ctcctctaca tctggaggag tatcctctac atccaatatg     2280

catgggtcac tgttacaaga gaagcaccgg attttgcaca agttgctgca gaatgggaat     2340

tcaccagctg aggtagccaa gattactgca gaagccactg ggaaagacac cagcagtata     2400

acttcttgtg gggacggaaa tgttgtcaag caggagcagc taagtcctaa gaagaaggag     2460

aataatgcac ttcttagata cctgctggac agggatgatc ctagtgatgc actctctaaa     2520

gaactacagc cccaagtgga aggagtggat aataaaatga gtcagtgcac cagctccacc     2580

attcctagct caagtcaaga gaaagaccct aaaattaaga cagagacaag tgaagaggga     2640

tctggagact tggataatct agatgctatt cttggtgatc tgactagttc tgacttttac     2700

aataattcca tatcctcaaa tggtagtcat ctggggacta agcaacaggt gtttcaagga     2760

actaattctc tgggtttgaa aagttcacag tctgtgcagt ctattcgtcc tccatataac     2820

cgagcagtgt ctctggatag ccctgtttct gttggctcaa gtcctccagt aaaaaatatc     2880

agtgctttcc ccatgttacc aaagcaaccc atgttgggtg ggaatccaag aatgatggat     2940

agtcaggaaa attatggctc aagtatgggt gggccaaacc gaaatgtgac tgtgactcag     3000

actccttcct caggagactg gggcttacca aactcaaagg ccggcagaat ggaacctatg     3060

aattcaaact ccatgggaag accaggagga gattataata cttctttacc cagacctgca     3120

ctgggtggct ctattcccac attgcctctt cggtctaata gcataccagg tgcgagacca     3180

gtattgcaac agcagcagca gatgcttcaa atgaggcctg gtgaaatccc catgggaatg     3240

ggggctaatc cctatggcca agcagcagca tctaaccaac tgggttcctg gcccgatggc     3300

atgttgtcca tggaacaagt ttctcatggc actcaaaata ggcctcttct taggaattcc     3360

ctggatgatc ttgttgggcc accttccaac ctggaaggcc agagtgacga aagagcatta     3420

ttggaccagc tgcacactct tctcagcaac acagatgcca caggcctgga agaaattgac     3480

agagctttgg gcattcctga acttgtcaat cagggacagg cattagagcc caaacaggat     3540

gctttccaag gccaagaagc agcagtaatg atggatcaga aggcaggatt atatggacag     3600

acatacccag cacaggggcc tccaatgcaa ggaggctttc atcttcaggg acaatcacca     3660

tcttttaact ctatgatgaa tcagatgaac cagcaaggca attttcctct ccaaggaatg     3720

cacccacgag ccaacatcat gagaccccgg acaaacaccc ccaagcaact tagaatgcag     3780

cttcagcaga ggctgcaggg ccagcagttt ttgaatcaga gccgacaggc acttgaattg     3840

aaaatggaaa accctactgc tggtggtgct gcggtgatga ggcctatgat gcagccccag     3900

gtgagctccc agcagggttt tcttaatgct caaatggtcg cccaacgcag cagagagctg     3960

ctaagtcatc acttccgaca acagagggtg gctatgatga tgcagcagca gcagcagcag     4020

caacagcagc agcagcagca gcagcagcag caacagcaac agcaacagca acagcagcaa     4080

cagcagcaaa cccaggcctt cagcccacct cctaatgtga ctgcttcccc cagcatggat     4140

gggcttttgg caggacccac aatgccacaa gctcctccgc aacagtttcc atatcaacca     4200

aattatggaa tgggacaaca accagatcca gcctttggtc gagtgtctag tcctcccaat     4260

gcaatgatgt cgtcaagaat gggtccctcc cagaatccca tgatgcaaca cccgcaggct     4320

gcatccatct atcagtcctc agaaatgaag ggctggccat caggaaattt ggccaggaac     4380

agctcctttt cccagcagca gtttgcccac caggggaatc ctgcagtgta tagtatggtg     4440

cacatgaatg gcagcagtgg tcacatggga cagatgaaca tgaaccccat gcccatgtct     4500

ggcatgccta tgggtcctga tcagaaatac tgctgacatc tctgcaccag gacctcttaa     4560

ggaaaccact gtacaaatga cactgcacta ggattattgg gaaggaatca ttgttccagg     4620

catccatctt ggaagaaagg accagctttg agctccatca agggtatttt aagtgatgtc     4680

atttgagcag gactggattt taagccgaag ggcaatatct acgtgttttt cccccctcct     4740

tctgctgtgt atcatggtgt tcaaaacaga aatgtttttt ggcattccac ctcctaggga     4800

tataattctg gagacatgga gtgttactga tcataaaact tttgtgtcac ttttttctgc     4860

cttgctagcc aaaatctctt aaatacacgt aggtgggcca gagaacattg gaagaatcaa     4920

gagagattag aatatctggt ttctctagtt gcagtattgg acaaagagca tagtcccagc     4980

cttcaggtgt agtagttctg tgttgaccct ttgtccagtg gaattggtga ttctgaattg     5040

tcctttacta atggtgttga gttgctctgt ccctattatt tgccctaggc tttctcctaa     5100

tgaaggtttt catttgccat tcatgtcctg taatacttca cctccaggaa ctgtcatgga     5160

tgtccaaatg gctttgcaga aaggaaatga gatgacagta tttaatcgca gcagtagcaa     5220

acttttcaca tgctaatgtg cagctgagtg cactttattt aaaaagaatg gataaatgca     5280

atattcttga ggtcttgagg gaatagtgaa acacattcct ggtttttgcc tacacttacg     5340

tgttagacaa gaactatgat tttttttttt aaagtactgg tgtcaccctt tgcctatatg     5400

gtagagcaat aatgcttttt aaaaataaac ttctgaaaac ccaaggccag gtactgcatt     5460

ctgaatcaga atctcgcagt gtttctgtga atagattttt ttgtaaatat gacctttaag     5520

atattgtatt atgtaaaata tgtatatacc tttttttgta ggtcacaaca actcattttt     5580

acagagtttg tgaagctaaa tatttaacat tgttgatttc agtaagctgt gtggtgaggc     5640

taccagtgga agagacatcc cttgactttt gtggcctggg ggaggggtag tgctccacag     5700

cttttccttc cccacccccc agccttagat gcctcgctct tttcaatctc ttaatctaaa     5760

tgctttttaa agagattatt tgtttagatg taggcatttt aattttttaa aaattcctct     5820

accagaacta agcactttgt taatttgggg ggaaagaata gatatgggga aataaactta     5880

aaaaaaaatc aggaatttaa aaaaacgagc aatttgaaga gaatcttttg gattttaagc     5940

agtccgaaat aatagcaatt catgggctgt gtgtgtgtgt gtatgtgtgt gtgtgtgtgt     6000

gtatgtttaa ttatgttacc ttttcatccc ctttaggagc gttttcagat tttggttgct     6060

aagacctgaa tcccatattg agatctcgag tagaatcctt ggtgtggttt ctggtgtctg     6120

ctcagctgtc ccctcattct actaatgtga tgctttcatt atgtccctgt ggattagaat     6180

agtgtcagtt atttcttaag taactcagta cccagaacag ccagttttac tgtgattcag     6240

agccacagtc taactgagca ccttttaaac ccctccctct tctgccccct accacttttc     6300

tgctgttgcc tctctttgac acctgtttta gtcagttggg aggaagggaa aaatcaagtt     6360

taattccctt tatctgggtt aattcatttg gttcaaatag ttgacggaat tgggtttctg     6420

aatgtctgtg aatttcagag gtctctgcta gccttggtat cattttctag caataactga     6480

gagccagtta attttaagaa tttcacacat ttagccaatc tttctagatg tctctgaagg     6540

taagatcatt taatatcttt gatatgctta cgagtaagtg aatcctgatt atttccagac     6600

ccaccaccag agtggatctt attttcaaag cagtatagac aattatgagt ttgccctctt     6660

tcccctacca agttcaaaat atatctaaga aagattgtaa atccgaaaac ttccattgta     6720

gtggcctgtg cttttcagat agtatactct cctgtttgga gacagaggaa gaaccaggtc     6780

agtctgtctc tttttcagct caattgtatc tgacccttct ttaagttatg tgtgtgggga     6840

gaaatagaat ggtgctctta tctttcttga ctttaaaaaa attattaaaa acaaaaaaaa     6900

aataaatttt tttgcaatcc tttcctcaga cctggctcca ggctaactgg aaggcagcac     6960

tccctttttt atatagtaga aaaatgaagt ttattataag tttttatatt ttctacttgt     7020

tcatttggtg caaactcaag atttctttta ataggtgcag tctttgagat aatttgtttt     7080

tacctgtatt gccctttatc ttttttaggt aattctttgt actcctgctg tctacctctc     7140

ctcacacccc agcacccccc attttttcaa accttggtat ctgttgggtg aacagtataa     7200

tcttttcatc tgcttttaga atgtgggata tttccagtac ctactttttt tttttttttt     7260

tgctgaatcc aaagatatat aaataaaata tatatatttt ataaagatca gaatgatata     7320

aaggagatac atgtttcttc ctttaaaaaa taaacggaag ttacattgtt aatgttcata     7380

ttatgatgcc acttttctaa actgcatctg gattgaaagg tgtaaatatc aataacagtg     7440

ctacttagtt atcagtattt aatatctgag gtgagttggg ggtatctata ttaggggtag     7500

ggtattacag aagataattg gcttgatgtc ctagaagttc tttgatccag aggtgggtgc     7560

agctgaaagt aaacagaatg gattgccagt tacatgtatg cctgcccagt tcccttttta     7620

tttgcagaag ctgtgagttt tgttcacaat taggttccta ggagcaaaac ctcaaggatt     7680

gatttattgt tttcaactcc aaggcacact gttaataaac gagcagggtg ttttctctct     7740

tcctttctaa tatatggagt ttcgaagaat aaaatatgag agcaatattt aaattctcag     7800

gaattgactt atactcttga gaatgaattc agtttcaatc aagtttacat tatgttgctt     7860

aaaaaaatag aaattattct ttatcttgca aagaattgaa accacatgaa atgacttatg     7920

ggggatggtg agctgtgact gctttgctga ccattttgga tgtcattgta aataaaggtt     7980

tctatttaaa attgga                                                     7996


<210>  2
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  2
tcgactgctg ttgaagtgag cgccgttgtc aatatagata caatagtgaa gccacagatg       60

tattgtatct atattgacaa cgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccgt tgtcaatgct gatccaatag tgaagccaca gatgtattgt      180

atctatattg acaacgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  3
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
tcgactgctg ttgaagtgag cgccaaagca aactcttccg aaatagtgaa gccacagatg       60

tatttcggaa gagtttgctt tgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccaa agcaaatact tctgaaatag tgaagccaca gatgtatttc      180

ggaagagttt gctttgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  4
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
tcgactgctg ttgaagtgag cgccgttgtc aatatagata caatagtgaa gccacagatg       60

tattgtatct atattgacaa cgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccga ggaagagaga ggtaagttag tgaagccaca gatgtaactg      180

acctggttct tcctcgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  5
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
tcgactgctg ttgaagtgag cgccaaagca aactcttccg aaatagtgaa gccacagatg       60

tatttcggaa gagtttgctt tgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccga ggaagagaga ggtaagttag tgaagccaca gatgtaactg      180

acctggttct tcctcgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  6
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
tcgactgctg ttgaagtgag cgcccctata tggtagagca atatagtgaa gccacagatg       60

tatattgctc taccatatag ggttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgcccc tatatgcatg atcaatatag tgaagccaca gatgtatatt      180

gctctaccat atagggttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  7
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
tcgactgctg ttgaagtgag cgccggaaat gagatgacag tattagtgaa gccacagatg       60

taatactgtc atctcatttc cgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccgg aaatgactag acactattag tgaagccaca gatgtaatac      180

tgtcatctca tttccgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  8
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  8
tcgactgctg ttgaagtgag cgccatggaa ggtacaggaa tattagtgaa gccacagatg       60

taatattcct gtaccttcca tgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccat ggaaggacta gtaatattag tgaagccaca gatgtaatat      180

tcctgtacct tccatgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  9
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  9
tcgactgctg ttgaagtgag cgcctcatgg gaattcatat cattagtgaa gccacagatg       60

taatgatatg aattcccatg agttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgcctc atgggacaac atctcattag tgaagccaca gatgtaatga      180

tatgaattcc catgagttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  10
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  10
tcgactgctg ttgaagtgag cgccccacca atcagaaaca gtatagtgaa gccacagatg       60

tatactgttt ctgattggtg ggttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgcccc accaatgtca aatagtatag tgaagccaca gatgtatact      180

gtttctgatt ggtgggttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


<210>  11
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  11
tcgactgctg ttgaagtgag cgccggagga gattgataga gcctagtgaa gccacagatg       60

taggctctat caatctcctc cgttgcctac tgcctcggaa gcagctcact acattactca      120

gctgttgaag tgagcgccgg aggagacata tacagcctag tgaagccaca gatgtaggct      180

ctatcaatct cctccgttgc ctactgcctc ggaagcttaa taaaggatct tttattttca      240

ttggc                                                                  245


