                         SEQUENCE LISTING

<110>  University of California, Los Angeles
       Lee, Benhur
       Palomares, Karina
       Pernet, Olivier
 
<120>  Nipah Virus Envelope Psuedotyped Lentiviruses And Methods Of 
       Their Use

<130>  0069697-000078

<150>  US 61/615,534
<151>  2012-03-26

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  PRT
<213>  Nipah virus

<400>  1

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr 
545     


<210>  2
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  2

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr Asp Thr Tyr Arg Tyr Ile 
545                 550         


<210>  3
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  3
atggtggtga tcctggacaa gcggtgctac tgcaacctgc tgatcctgat cctgatgatc       60

agcgagtgca gcgtgggcat cctgcactac gagaagctga gcaagatcgg cctggtgaag      120

ggcgtgaccc ggaagtacaa gatcaagagc aaccccctga ccaaggacat cgtgatcaag      180

atgatcccca acgtgagcaa catgagccag tgcaccggca gcgtgatgga gaactacaag      240

acccggctga acggcatcct gacccccatc aagggcgccc tggagatcta caagaacaac      300

acccacgacc tggtgggcga cgtgcggctg gccggcgtga tcatggccgg cgtggccatc      360

ggcatcgcca cagccgccca gatcaccgcc ggagtggccc tgtacgaggc catgaagaac      420

gccgacaaca tcaacaagct gaagagcagc atcgagagca ccaacgaggc cgtggtgaag      480

ctgcaggaga ccgccgagaa aaccgtgtac gtgctgaccg ccctgcagga ctacatcaac      540

accaacctgg tgcccaccat cgacaagatc agctgcaagc agaccgagct gagcctggac      600

ctggccctga gcaagtacct gagcgacctg ctgttcgtgt tcggccccaa cctgcaggac      660

cccgtgagca acagcatgac catccaggcc atcagccagg ccttcggcgg caactacgag      720

accctgctgc ggaccctggg ctacgccacc gaggacttcg acgacctgct ggagagcgac      780

agcatcaccg gccagatcat ctacgtggac ctgagcagct actacatcat cgtgcgggtg      840

tacttcccca tcctgaccga gatccagcag gcctacatcc aggagctgct gcccgtgagc      900

ttcaacaacg acaacagcga gtggatcagc atcgtgccca acttcatcct ggtgcggaac      960

accctgatca gcaacatcga gatcggcttc tgcctgatca ccaagcggag cgtgatctgc     1020

aaccaggact acgccacccc catgaccaac aacatgcggg agtgcctgac cggcagcacc     1080

gagaagtgcc ccagggagct ggtggtgagc agccacgtgc cccggttcgc cctgagcaac     1140

ggcgtgctgt tcgccaactg catcagcgtg acctgccagt gccagaccac cggcagagcc     1200

atcagccaga gcggcgagca gaccctgctg atgatcgaca acaccacctg ccccaccgcc     1260

gtgctgggca acgtgatcat cagcctgggc aagtatctgg gcagcgtgaa ctacaacagc     1320

gagggcatcg ccatcggccc tcccgtgttc accgacaagg tggacatcag cagccagatc     1380

agcagcatga accagagcct gcagcagagc aaggattaca tcaaggaggc ccagcggctg     1440

ctggacaccg tgaaccccag cctgatcagc atgctgtcca tgatcatcct gtacgtgctg     1500

agcatcgcca gcctgtgcat cggcctgatc accttcatca gcttcatcat cgtggagaag     1560

aagcggaaca cctacagccg gctggaggac cggcgggtgc ggcccaccag cagcggcgac     1620

ctgtactaca tcggcaccga cacctaccgg tacatctaa                            1659


<210>  4
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  4

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Asn Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Gly Thr Asp Thr 
        515                 520                 525             


Tyr Arg Tyr Ile 
    530         


<210>  5
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  5
atggtggtga tcctggacaa gcggtgctac tgcaacctgc tgatcctgat cctgatgatc       60

agcgagtgca gcgtgggcat cctgcactac gagaagctga gcaagatcgg cctggtgaag      120

ggcgtgaccc ggaagtacaa gatcaagagc aaccccctga ccaaggacat cgtgatcaag      180

atgatcccca acgtgagcaa catgagccag tgcaccggca gcgtgatgga gaactacaag      240

acccggctga acggcatcct gacccccatc aagggcgccc tggagatcta caagaacaac      300

acccacgacc tggtgggcga cgtgcggctg gccggcgtga tcatggccgg cgtggccatc      360

ggcatcgcca cagccgccca gatcaccgcc ggagtggccc tgtacgaggc catgaagaac      420

gccgacaaca tcaacaagct gaagagcagc atcgagagca ccaacgaggc cgtggtgaag      480

ctgcaggaga ccgccgagaa aaccgtgtac gtgctgaccg ccctgcagga ctacatcaac      540

accaacctgg tgcccaccat cgacaagatc agctgcaagc agaccgagct gagcctggac      600

ctggccctga gcaagtacct gagcgacctg ctgttcgtgt tcggccccaa cctgcaggac      660

cccgtgagca acagcatgac catccaggcc atcagccagg ccttcggcgg caactacgag      720

accctgctgc ggaccctggg ctacgccacc gaggacttcg acgacctgct ggagagcgac      780

agcatcaccg gccagatcat ctacgtggac ctgagcagct actacatcat cgtgcgggtg      840

tacttcccca tcctgaccga gatccagcag gcctacatcc aggagctgct gcccgtgagc      900

ttcaacaacg acaacagcga gtggatcagc atcgtgccca acttcatcct ggtgcggaac      960

accctgatca gcaacatcga gatcggcttc tgcctgatca ccaagcggag cgtgatctgc     1020

aaccaggact acgccacccc catgaccaac aacatgcggg agtgcctgac cggcagcacc     1080

gagaagtgcc ccagggagct ggtggtgagc agccacgtgc cccggttcgc cctgagcaac     1140

ggcgtgctgt tcgccaactg catcagcgtg acctgccagt gccagaccac cggcagagcc     1200

atcagccaga gcggcgagca gaccctgctg atgatcgaca acaccacctg ccccaccgcc     1260

gtgctgggca acgtgatcat cagcctgggc aagtatctgg gcagcgtgaa ctacaacagc     1320

gagggcatcg ccatcggccc tcccgtgttc accgacaagg tggacatcag cagccagatc     1380

agcagcatga accagagcct gcagcagagc aaggattaca tcaaggaggc ccagcggctg     1440

ctggacaccg tgaaccccag cctgatcagc atgctgtcca tgatcatcct gtacgtgctg     1500

agcatcgcca gcctgtgcat cggcctgatc accttcatca gcttcatcat cgtggagaag     1560

aagcggaaca ccggcaccga cacctaccgg tacatctaa                            1599


<210>  6
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  6

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Gln Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Tyr Ser Arg Leu 
        515                 520                 525             


Glu Asp Arg Arg Val Arg Pro Thr Ser Ser Gly Asp Leu Tyr Tyr Ile 
    530                 535                 540                 


Gly Thr Asp Thr Tyr Arg Tyr Ile 
545                 550         


<210>  7
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  7
atggtggtga tcctggacaa gcggtgctac tgcaacctgc tgatcctgat cctgatgatc       60

agcgagtgca gcgtgggcat cctgcactac gagaagctga gcaagatcgg cctggtgaag      120

ggcgtgaccc ggaagtacaa gatcaagagc aaccccctga ccaaggacat cgtgatcaag      180

atgatcccca acgtgagcaa catgagccag tgcaccggca gcgtgatgga gaactacaag      240

acccggctga acggcatcct gacccccatc aagggcgccc tggagatcta caagcaraac      300

acccacgacc tggtgggcga cgtgcggctg gccggcgtga tcatggccgg cgtggccatc      360

ggcatcgcca cagccgccca gatcaccgcc ggagtggccc tgtacgaggc catgaagaac      420

gccgacaaca tcaacaagct gaagagcagc atcgagagca ccaacgaggc cgtggtgaag      480

ctgcaggaga ccgccgagaa aaccgtgtac gtgctgaccg ccctgcagga ctacatcaac      540

accaacctgg tgcccaccat cgacaagatc agctgcaagc agaccgagct gagcctggac      600

ctggccctga gcaagtacct gagcgacctg ctgttcgtgt tcggccccaa cctgcaggac      660

cccgtgagca acagcatgac catccaggcc atcagccagg ccttcggcgg caactacgag      720

accctgctgc ggaccctggg ctacgccacc gaggacttcg acgacctgct ggagagcgac      780

agcatcaccg gccagatcat ctacgtggac ctgagcagct actacatcat cgtgcgggtg      840

tacttcccca tcctgaccga gatccagcag gcctacatcc aggagctgct gcccgtgagc      900

ttcaacaacg acaacagcga gtggatcagc atcgtgccca acttcatcct ggtgcggaac      960

accctgatca gcaacatcga gatcggcttc tgcctgatca ccaagcggag cgtgatctgc     1020

aaccaggact acgccacccc catgaccaac aacatgcggg agtgcctgac cggcagcacc     1080

gagaagtgcc ccagggagct ggtggtgagc agccacgtgc cccggttcgc cctgagcaac     1140

ggcgtgctgt tcgccaactg catcagcgtg acctgccagt gccagaccac cggcagagcc     1200

atcagccaga gcggcgagca gaccctgctg atgatcgaca acaccacctg ccccaccgcc     1260

gtgctgggca acgtgatcat cagcctgggc aagtatctgg gcagcgtgaa ctacaacagc     1320

gagggcatcg ccatcggccc tcccgtgttc accgacaagg tggacatcag cagccagatc     1380

agcagcatga accagagcct gcagcagagc aaggattaca tcaaggaggc ccagcggctg     1440

ctggacaccg tgaaccccag cctgatcagc atgctgtcca tgatcatcct gtacgtgctg     1500

agcatcgcca gcctgtgcat cggcctgatc accttcatca gcttcatcat cgtggagaag     1560

aagcggaaca cctacagccg gctggaggac cggcgggtgc ggcccaccag cagcggcgac     1620

ctgtactaca tcggcaccga cacctaccgg tacatctaa                            1659


<210>  8
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  8

Met Val Val Ile Leu Asp Lys Arg Cys Tyr Cys Asn Leu Leu Ile Leu 
1               5                   10                  15      


Ile Leu Met Ile Ser Glu Cys Ser Val Gly Ile Leu His Tyr Glu Lys 
            20                  25                  30          


Leu Ser Lys Ile Gly Leu Val Lys Gly Val Thr Arg Lys Tyr Lys Ile 
        35                  40                  45              


Lys Ser Asn Pro Leu Thr Lys Asp Ile Val Ile Lys Met Ile Pro Asn 
    50                  55                  60                  


Val Ser Asn Met Ser Gln Cys Thr Gly Ser Val Met Glu Asn Tyr Lys 
65                  70                  75                  80  


Thr Arg Leu Asn Gly Ile Leu Thr Pro Ile Lys Gly Ala Leu Glu Ile 
                85                  90                  95      


Tyr Lys Gln Asn Thr His Asp Leu Val Gly Asp Val Arg Leu Ala Gly 
            100                 105                 110         


Val Ile Met Ala Gly Val Ala Ile Gly Ile Ala Thr Ala Ala Gln Ile 
        115                 120                 125             


Thr Ala Gly Val Ala Leu Tyr Glu Ala Met Lys Asn Ala Asp Asn Ile 
    130                 135                 140                 


Asn Lys Leu Lys Ser Ser Ile Glu Ser Thr Asn Glu Ala Val Val Lys 
145                 150                 155                 160 


Leu Gln Glu Thr Ala Glu Lys Thr Val Tyr Val Leu Thr Ala Leu Gln 
                165                 170                 175     


Asp Tyr Ile Asn Thr Asn Leu Val Pro Thr Ile Asp Lys Ile Ser Cys 
            180                 185                 190         


Lys Gln Thr Glu Leu Ser Leu Asp Leu Ala Leu Ser Lys Tyr Leu Ser 
        195                 200                 205             


Asp Leu Leu Phe Val Phe Gly Pro Asn Leu Gln Asp Pro Val Ser Asn 
    210                 215                 220                 


Ser Met Thr Ile Gln Ala Ile Ser Gln Ala Phe Gly Gly Asn Tyr Glu 
225                 230                 235                 240 


Thr Leu Leu Arg Thr Leu Gly Tyr Ala Thr Glu Asp Phe Asp Asp Leu 
                245                 250                 255     


Leu Glu Ser Asp Ser Ile Thr Gly Gln Ile Ile Tyr Val Asp Leu Ser 
            260                 265                 270         


Ser Tyr Tyr Ile Ile Val Arg Val Tyr Phe Pro Ile Leu Thr Glu Ile 
        275                 280                 285             


Gln Gln Ala Tyr Ile Gln Glu Leu Leu Pro Val Ser Phe Asn Asn Asp 
    290                 295                 300                 


Asn Ser Glu Trp Ile Ser Ile Val Pro Asn Phe Ile Leu Val Arg Asn 
305                 310                 315                 320 


Thr Leu Ile Ser Asn Ile Glu Ile Gly Phe Cys Leu Ile Thr Lys Arg 
                325                 330                 335     


Ser Val Ile Cys Asn Gln Asp Tyr Ala Thr Pro Met Thr Asn Asn Met 
            340                 345                 350         


Arg Glu Cys Leu Thr Gly Ser Thr Glu Lys Cys Pro Arg Glu Leu Val 
        355                 360                 365             


Val Ser Ser His Val Pro Arg Phe Ala Leu Ser Asn Gly Val Leu Phe 
    370                 375                 380                 


Ala Asn Cys Ile Ser Val Thr Cys Gln Cys Gln Thr Thr Gly Arg Ala 
385                 390                 395                 400 


Ile Ser Gln Ser Gly Glu Gln Thr Leu Leu Met Ile Asp Asn Thr Thr 
                405                 410                 415     


Cys Pro Thr Ala Val Leu Gly Asn Val Ile Ile Ser Leu Gly Lys Tyr 
            420                 425                 430         


Leu Gly Ser Val Asn Tyr Asn Ser Glu Gly Ile Ala Ile Gly Pro Pro 
        435                 440                 445             


Val Phe Thr Asp Lys Val Asp Ile Ser Ser Gln Ile Ser Ser Met Asn 
    450                 455                 460                 


Gln Ser Leu Gln Gln Ser Lys Asp Tyr Ile Lys Glu Ala Gln Arg Leu 
465                 470                 475                 480 


Leu Asp Thr Val Asn Pro Ser Leu Ile Ser Met Leu Ser Met Ile Ile 
                485                 490                 495     


Leu Tyr Val Leu Ser Ile Ala Ser Leu Cys Ile Gly Leu Ile Thr Phe 
            500                 505                 510         


Ile Ser Phe Ile Ile Val Glu Lys Lys Arg Asn Thr Gly Thr Asp Thr 
        515                 520                 525             


Tyr Arg Tyr Ile 
    530         


<210>  9
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  9
atggtggtga tcctggacaa gcggtgctac tgcaacctgc tgatcctgat cctgatgatc       60

agcgagtgca gcgtgggcat cctgcactac gagaagctga gcaagatcgg cctggtgaag      120

ggcgtgaccc ggaagtacaa gatcaagagc aaccccctga ccaaggacat cgtgatcaag      180

atgatcccca acgtgagcaa catgagccag tgcaccggca gcgtgatgga gaactacaag      240

acccggctga acggcatcct gacccccatc aagggcgccc tggagatcta caagcaraac      300

acccacgacc tggtgggcga cgtgcggctg gccggcgtga tcatggccgg cgtggccatc      360

ggcatcgcca cagccgccca gatcaccgcc ggagtggccc tgtacgaggc catgaagaac      420

gccgacaaca tcaacaagct gaagagcagc atcgagagca ccaacgaggc cgtggtgaag      480

ctgcaggaga ccgccgagaa aaccgtgtac gtgctgaccg ccctgcagga ctacatcaac      540

accaacctgg tgcccaccat cgacaagatc agctgcaagc agaccgagct gagcctggac      600

ctggccctga gcaagtacct gagcgacctg ctgttcgtgt tcggccccaa cctgcaggac      660

cccgtgagca acagcatgac catccaggcc atcagccagg ccttcggcgg caactacgag      720

accctgctgc ggaccctggg ctacgccacc gaggacttcg acgacctgct ggagagcgac      780

agcatcaccg gccagatcat ctacgtggac ctgagcagct actacatcat cgtgcgggtg      840

tacttcccca tcctgaccga gatccagcag gcctacatcc aggagctgct gcccgtgagc      900

ttcaacaacg acaacagcga gtggatcagc atcgtgccca acttcatcct ggtgcggaac      960

accctgatca gcaacatcga gatcggcttc tgcctgatca ccaagcggag cgtgatctgc     1020

aaccaggact acgccacccc catgaccaac aacatgcggg agtgcctgac cggcagcacc     1080

gagaagtgcc ccagggagct ggtggtgagc agccacgtgc cccggttcgc cctgagcaac     1140

ggcgtgctgt tcgccaactg catcagcgtg acctgccagt gccagaccac cggcagagcc     1200

atcagccaga gcggcgagca gaccctgctg atgatcgaca acaccacctg ccccaccgcc     1260

gtgctgggca acgtgatcat cagcctgggc aagtatctgg gcagcgtgaa ctacaacagc     1320

gagggcatcg ccatcggccc tcccgtgttc accgacaagg tggacatcag cagccagatc     1380

agcagcatga accagagcct gcagcagagc aaggattaca tcaaggaggc ccagcggctg     1440

ctggacaccg tgaaccccag cctgatcagc atgctgtcca tgatcatcct gtacgtgctg     1500

agcatcgcca gcctgtgcat cggcctgatc accttcatca gcttcatcat cgtggagaag     1560

aagcggaaca ccggcaccga cacctaccgg tacatctaa                            1599


<210>  10
<211>  602
<212>  PRT
<213>  Nipah virus

<400>  10

Met Gly Pro Ala Glu Asn Lys Lys Val Arg Phe Glu Asn Thr Thr Ser 
1               5                   10                  15      


Asp Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr 
            20                  25                  30          


Met Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu 
        35                  40                  45              


Ser Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile 
    50                  55                  60                  


Val Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn 
65                  70                  75                  80  


Gln Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys 
                85                  90                  95      


Gly Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu 
            100                 105                 110         


Ile Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu 
        115                 120                 125             


Gly Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn 
    130                 135                 140                 


Glu Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn 
145                 150                 155                 160 


Ile Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr 
                165                 170                 175     


Glu Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln 
            180                 185                 190         


Lys Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu 
        195                 200                 205             


Pro Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala 
    210                 215                 220                 


Met Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser 
225                 230                 235                 240 


Cys Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val 
                245                 250                 255     


Leu Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp 
            260                 265                 270         


Thr Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn 
        275                 280                 285             


Asn Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro 
    290                 295                 300                 


Ile Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu 
305                 310                 315                 320 


Ala Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu 
                325                 330                 335     


Ala Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr 
            340                 345                 350         


Gly Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val 
        355                 360                 365             


Gly Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro 
    370                 375                 380                 


Ile Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met 
385                 390                 395                 400 


Gly Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys 
                405                 410                 415     


Tyr Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile 
            420                 425                 430         


Ser Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser 
        435                 440                 445             


Leu Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met 
    450                 455                 460                 


Ile Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp 
465                 470                 475                 480 


Arg Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg 
                485                 490                 495     


Phe Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala 
            500                 505                 510         


Phe Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp 
        515                 520                 525             


Ser Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn 
    530                 535                 540                 


Glu Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln 
545                 550                 555                 560 


Lys Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile 
                565                 570                 575     


Ser Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys 
            580                 585                 590         


Leu Phe Ala Val Lys Ile Pro Glu Gln Cys 
        595                 600         


<210>  11
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  11

Met Gly Pro Ala Glu Asn Lys Lys Val Arg Phe Glu Asn Thr Thr Ser 
1               5                   10                  15      


Asp Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr 
            20                  25                  30          


Met Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu 
        35                  40                  45              


Ser Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile 
    50                  55                  60                  


Val Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn 
65                  70                  75                  80  


Gln Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys 
                85                  90                  95      


Gly Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu 
            100                 105                 110         


Ile Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu 
        115                 120                 125             


Gly Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn 
    130                 135                 140                 


Glu Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn 
145                 150                 155                 160 


Ile Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr 
                165                 170                 175     


Glu Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln 
            180                 185                 190         


Lys Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu 
        195                 200                 205             


Pro Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala 
    210                 215                 220                 


Met Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser 
225                 230                 235                 240 


Cys Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val 
                245                 250                 255     


Leu Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp 
            260                 265                 270         


Thr Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn 
        275                 280                 285             


Asn Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro 
    290                 295                 300                 


Ile Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu 
305                 310                 315                 320 


Ala Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu 
                325                 330                 335     


Ala Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr 
            340                 345                 350         


Gly Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val 
        355                 360                 365             


Gly Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro 
    370                 375                 380                 


Ile Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met 
385                 390                 395                 400 


Gly Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys 
                405                 410                 415     


Tyr Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile 
            420                 425                 430         


Ser Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser 
        435                 440                 445             


Leu Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met 
    450                 455                 460                 


Ile Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp 
465                 470                 475                 480 


Arg Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg 
                485                 490                 495     


Phe Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala 
            500                 505                 510         


Phe Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp 
        515                 520                 525             


Ser Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn 
    530                 535                 540                 


Glu Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln 
545                 550                 555                 560 


Lys Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile 
                565                 570                 575     


Ser Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys 
            580                 585                 590         


Leu Phe Ala Val Lys Ile Pro Glu Gln Cys Tyr Pro Tyr Asp Val Pro 
        595                 600                 605             


Asp Tyr Ala 
    610     


<210>  12
<211>  1836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  12
atgggacctg ccgagaacaa gaaagtgcgg ttcgagaaca ccacaagcga caagggcaag       60

atccccagca aagtgatcaa gagctactac ggcaccatgg acatcaagaa gatcaacgag      120

ggcctgctgg acagcaagat cctgagcgcc ttcaacaccg tgatcgccct gctgggcagc      180

atcgtgatca ttgtgatgaa catcatgatc atccagaact acacccggag caccgacaac      240

caggccgtga tcaaggacgc cctgcaggga atccagcagc agatcaaggg cctggccgac      300

aagatcggca ccgagatcgg ccccaaagtg agcctgatcg acaccagcag caccatcacc      360

atccccgcca acatcggcct gctgggatcc aagatcagcc agagcaccgc cagcatcaac      420

gagaacgtga acgagaagtg caagttcacc ctgccccccc tgaagatcca cgagtgcaac      480

atcagctgcc ccaaccccct gcccttccgg gagtaccggc cccagaccga gggcgtgagc      540

aacctggtgg gcctgcccaa caacatctgc ctgcagaaaa ccagcaacca gatcctgaag      600

cccaagctga tctcctacac cctgcccgtg gtgggccaga gcggcacctg catcaccgac      660

cccctgctgg ccatggacga gggctacttc gcctacagcc acctggagcg gatcggcagc      720

tgcagccggg gagtgagcaa gcagcggatc atcggcgtgg gcgaagtgct ggaccggggc      780

gacgaagtgc ccagcctgtt catgaccaac gtgtggaccc cccccaaccc caacaccgtg      840

taccactgca gcgccgtgta caacaacgag ttctactacg tgctgtgcgc cgtgagcacc      900

gtgggcgacc ccatcctgaa cagcacctac tggagcggca gcctgatgat gacccggctg      960

gccgtgaagc ctaagagcaa cggcggaggc tacaaccagc accagctggc cctgcggagc     1020

atcgagaagg gccggtacga caaagtgatg ccctacggcc ccagcggcat caagcagggc     1080

gacaccctgt acttccccgc cgtgggcttc ctggtgcgga ccgagttcaa gtacaacgac     1140

agcaactgcc ccatcaccaa gtgccagtac agcaagcccg agaactgccg gctgagcatg     1200

ggcatccggc ccaacagcca ctacatcctg cggagcggcc tgctgaagta caacctgagc     1260

gacggcgaga accccaaagt ggtgttcatc gagatcagcg accagagact gagcatcggc     1320

agccccagca agatctacga cagcctgggc cagcccgtgt tctaccaggc cagcttcagc     1380

tgggacacca tgatcaagtt cggcgacgtg ctgaccgtga accccctggt ggtgaactgg     1440

cggaacaata ccgtgatcag cagacccggc cagagccagt gcccccggtt caacacctgc     1500

cccgagatct gctgggaggg cgtgtacaac gacgccttcc tgatcgaccg gatcaactgg     1560

atcagcgccg gagtgttcct ggatagcaac cagaccgccg agaatcccgt gttcaccgtg     1620

tttaaggaca acgagatcct gtacagagcc cagctggcca gcgaggacac caacgcccag     1680

aaaaccatca ccaactgctt cctgctgaag aataagatct ggtgcatcag cctggtggag     1740

atctacgata ccggcgacaa cgtgatcagg cccaagctgt tcgccgtgaa gatccccgag     1800

cagtgctacc cctacgacgt gcccgactac gcctga                               1836


<210>  13
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  13

Met Gly Lys Val Arg Phe Glu Asn Thr Thr Ser Asp Lys Gly Lys Ile 
1               5                   10                  15      


Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr Met Asp Ile Lys Lys 
            20                  25                  30          


Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala Phe Asn Thr 
        35                  40                  45              


Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met Asn Ile Met 
    50                  55                  60                  


Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala Val Ile Lys 
65                  70                  75                  80  


Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu Ala Asp Lys 
                85                  90                  95      


Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp Thr Ser Ser 
            100                 105                 110         


Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser Lys Ile Ser 
        115                 120                 125             


Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys Cys Lys Phe 
    130                 135                 140                 


Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser Cys Pro Asn 
145                 150                 155                 160 


Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly Val Ser Asn 
                165                 170                 175     


Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr Ser Asn Gln 
            180                 185                 190         


Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val Val Gly Gln 
        195                 200                 205             


Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp Glu Gly Tyr 
    210                 215                 220                 


Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser Arg Gly Val 
225                 230                 235                 240 


Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp Arg Gly Asp 
                245                 250                 255     


Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro Pro Asn Pro 
            260                 265                 270         


Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu Phe Tyr Tyr 
        275                 280                 285             


Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu Asn Ser Thr 
    290                 295                 300                 


Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val Lys Pro Lys 
305                 310                 315                 320 


Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu Arg Ser Ile 
                325                 330                 335     


Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro Ser Gly Ile 
            340                 345                 350         


Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe Leu Val Arg 
        355                 360                 365             


Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr Lys Cys Gln 
    370                 375                 380                 


Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile Arg Pro Asn 
385                 390                 395                 400 


Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn Leu Ser Asp 
                405                 410                 415     


Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp Gln Arg Leu 
            420                 425                 430         


Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly Gln Pro Val 
        435                 440                 445             


Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys Phe Gly Asp 
    450                 455                 460                 


Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn Asn Thr Val 
465                 470                 475                 480 


Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn Thr Cys Pro 
                485                 490                 495     


Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe Leu Ile Asp Arg 
            500                 505                 510         


Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn Gln Thr Ala 
        515                 520                 525             


Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile Leu Tyr Arg 
    530                 535                 540                 


Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr Ile Thr Asn 
545                 550                 555                 560 


Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu Val Glu Ile 
                565                 570                 575     


Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe Ala Val Lys 
            580                 585                 590         


Ile Pro Glu Gln Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        595                 600                 605     


<210>  14
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  14
atgggaaaag tgcggttcga gaacaccaca agcgacaagg gcaagatccc cagcaaagtg       60

atcaagagct actacggcac catggacatc aagaagatca acgagggcct gctggacagc      120

aagatcctga gcgccttcaa caccgtgatc gccctgctgg gcagcatcgt gatcattgtg      180

atgaacatca tgatcatcca gaactacacc cggagcaccg acaaccaggc cgtgatcaag      240

gacgccctgc agggaatcca gcagcagatc aagggcctgg ccgacaagat cggcaccgag      300

atcggcccca aagtgagcct gatcgacacc agcagcacca tcaccatccc cgccaacatc      360

ggcctgctgg gatccaagat cagccagagc accgccagca tcaacgagaa cgtgaacgag      420

aagtgcaagt tcaccctgcc ccccctgaag atccacgagt gcaacatcag ctgccccaac      480

cccctgccct tccgggagta ccggccccag accgagggcg tgagcaacct ggtgggcctg      540

cccaacaaca tctgcctgca gaaaaccagc aaccagatcc tgaagcccaa gctgatctcc      600

tacaccctgc ccgtggtggg ccagagcggc acctgcatca ccgaccccct gctggccatg      660

gacgagggct acttcgccta cagccacctg gagcggatcg gcagctgcag ccggggagtg      720

agcaagcagc ggatcatcgg cgtgggcgaa gtgctggacc ggggcgacga agtgcccagc      780

ctgttcatga ccaacgtgtg gacccccccc aaccccaaca ccgtgtacca ctgcagcgcc      840

gtgtacaaca acgagttcta ctacgtgctg tgcgccgtga gcaccgtggg cgaccccatc      900

ctgaacagca cctactggag cggcagcctg atgatgaccc ggctggccgt gaagcctaag      960

agcaacggcg gaggctacaa ccagcaccag ctggccctgc ggagcatcga gaagggccgg     1020

tacgacaaag tgatgcccta cggccccagc ggcatcaagc agggcgacac cctgtacttc     1080

cccgccgtgg gcttcctggt gcggaccgag ttcaagtaca acgacagcaa ctgccccatc     1140

accaagtgcc agtacagcaa gcccgagaac tgccggctga gcatgggcat ccggcccaac     1200

agccactaca tcctgcggag cggcctgctg aagtacaacc tgagcgacgg cgagaacccc     1260

aaagtggtgt tcatcgagat cagcgaccag agactgagca tcggcagccc cagcaagatc     1320

tacgacagcc tgggccagcc cgtgttctac caggccagct tcagctggga caccatgatc     1380

aagttcggcg acgtgctgac cgtgaacccc ctggtggtga actggcggaa caataccgtg     1440

atcagcagac ccggccagag ccagtgcccc cggttcaaca cctgccccga gatctgctgg     1500

gagggcgtgt acaacgacgc cttcctgatc gaccggatca actggatcag cgccggagtg     1560

ttcctggata gcaaccagac cgccgagaat cccgtgttca ccgtgtttaa ggacaacgag     1620

atcctgtaca gagcccagct ggccagcgag gacaccaacg cccagaaaac catcaccaac     1680

tgcttcctgc tgaagaataa gatctggtgc atcagcctgg tggagatcta cgataccggc     1740

gacaacgtga tcaggcccaa gctgttcgcc gtgaagatcc ccgagcagtg ctacccctac     1800

gacgtgcccg actacgcctg a                                               1821


<210>  15
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  15

Met Gly Asn Thr Thr Ser Asp Lys Gly Lys Ile Pro Ser Lys Val Ile 
1               5                   10                  15      


Lys Ser Tyr Tyr Gly Thr Met Asp Ile Lys Lys Ile Asn Glu Gly Leu 
            20                  25                  30          


Leu Asp Ser Lys Ile Leu Ser Ala Phe Asn Thr Val Ile Ala Leu Leu 
        35                  40                  45              


Gly Ser Ile Val Ile Ile Val Met Asn Ile Met Ile Ile Gln Asn Tyr 
    50                  55                  60                  


Thr Arg Ser Thr Asp Asn Gln Ala Val Ile Lys Asp Ala Leu Gln Gly 
65                  70                  75                  80  


Ile Gln Gln Gln Ile Lys Gly Leu Ala Asp Lys Ile Gly Thr Glu Ile 
                85                  90                  95      


Gly Pro Lys Val Ser Leu Ile Asp Thr Ser Ser Thr Ile Thr Ile Pro 
            100                 105                 110         


Ala Asn Ile Gly Leu Leu Gly Ser Lys Ile Ser Gln Ser Thr Ala Ser 
        115                 120                 125             


Ile Asn Glu Asn Val Asn Glu Lys Cys Lys Phe Thr Leu Pro Pro Leu 
    130                 135                 140                 


Lys Ile His Glu Cys Asn Ile Ser Cys Pro Asn Pro Leu Pro Phe Arg 
145                 150                 155                 160 


Glu Tyr Arg Pro Gln Thr Glu Gly Val Ser Asn Leu Val Gly Leu Pro 
                165                 170                 175     


Asn Asn Ile Cys Leu Gln Lys Thr Ser Asn Gln Ile Leu Lys Pro Lys 
            180                 185                 190         


Leu Ile Ser Tyr Thr Leu Pro Val Val Gly Gln Ser Gly Thr Cys Ile 
        195                 200                 205             


Thr Asp Pro Leu Leu Ala Met Asp Glu Gly Tyr Phe Ala Tyr Ser His 
    210                 215                 220                 


Leu Glu Arg Ile Gly Ser Cys Ser Arg Gly Val Ser Lys Gln Arg Ile 
225                 230                 235                 240 


Ile Gly Val Gly Glu Val Leu Asp Arg Gly Asp Glu Val Pro Ser Leu 
                245                 250                 255     


Phe Met Thr Asn Val Trp Thr Pro Pro Asn Pro Asn Thr Val Tyr His 
            260                 265                 270         


Cys Ser Ala Val Tyr Asn Asn Glu Phe Tyr Tyr Val Leu Cys Ala Val 
        275                 280                 285             


Ser Thr Val Gly Asp Pro Ile Leu Asn Ser Thr Tyr Trp Ser Gly Ser 
    290                 295                 300                 


Leu Met Met Thr Arg Leu Ala Val Lys Pro Lys Ser Asn Gly Gly Gly 
305                 310                 315                 320 


Tyr Asn Gln His Gln Leu Ala Leu Arg Ser Ile Glu Lys Gly Arg Tyr 
                325                 330                 335     


Asp Lys Val Met Pro Tyr Gly Pro Ser Gly Ile Lys Gln Gly Asp Thr 
            340                 345                 350         


Leu Tyr Phe Pro Ala Val Gly Phe Leu Val Arg Thr Glu Phe Lys Tyr 
        355                 360                 365             


Asn Asp Ser Asn Cys Pro Ile Thr Lys Cys Gln Tyr Ser Lys Pro Glu 
    370                 375                 380                 


Asn Cys Arg Leu Ser Met Gly Ile Arg Pro Asn Ser His Tyr Ile Leu 
385                 390                 395                 400 


Arg Ser Gly Leu Leu Lys Tyr Asn Leu Ser Asp Gly Glu Asn Pro Lys 
                405                 410                 415     


Val Val Phe Ile Glu Ile Ser Asp Gln Arg Leu Ser Ile Gly Ser Pro 
            420                 425                 430         


Ser Lys Ile Tyr Asp Ser Leu Gly Gln Pro Val Phe Tyr Gln Ala Ser 
        435                 440                 445             


Phe Ser Trp Asp Thr Met Ile Lys Phe Gly Asp Val Leu Thr Val Asn 
    450                 455                 460                 


Pro Leu Val Val Asn Trp Arg Asn Asn Thr Val Ile Ser Arg Pro Gly 
465                 470                 475                 480 


Gln Ser Gln Cys Pro Arg Phe Asn Thr Cys Pro Glu Ile Cys Trp Glu 
                485                 490                 495     


Gly Val Tyr Asn Asp Ala Phe Leu Ile Asp Arg Ile Asn Trp Ile Ser 
            500                 505                 510         


Ala Gly Val Phe Leu Asp Ser Asn Gln Thr Ala Glu Asn Pro Val Phe 
        515                 520                 525             


Thr Val Phe Lys Asp Asn Glu Ile Leu Tyr Arg Ala Gln Leu Ala Ser 
    530                 535                 540                 


Glu Asp Thr Asn Ala Gln Lys Thr Ile Thr Asn Cys Phe Leu Leu Lys 
545                 550                 555                 560 


Asn Lys Ile Trp Cys Ile Ser Leu Val Glu Ile Tyr Asp Thr Gly Asp 
                565                 570                 575     


Asn Val Ile Arg Pro Lys Leu Phe Ala Val Lys Ile Pro Glu Gln Cys 
            580                 585                 590         


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        595                 600     


<210>  16
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  16
atgggaaaca ccacaagcga caagggcaag atccccagca aagtgatcaa gagctactac       60

ggcaccatgg acatcaagaa gatcaacgag ggcctgctgg acagcaagat cctgagcgcc      120

ttcaacaccg tgatcgccct gctgggcagc atcgtgatca ttgtgatgaa catcatgatc      180

atccagaact acacccggag caccgacaac caggccgtga tcaaggacgc cctgcaggga      240

atccagcagc agatcaaggg cctggccgac aagatcggca ccgagatcgg ccccaaagtg      300

agcctgatcg acaccagcag caccatcacc atccccgcca acatcggcct gctgggatcc      360

aagatcagcc agagcaccgc cagcatcaac gagaacgtga acgagaagtg caagttcacc      420

ctgccccccc tgaagatcca cgagtgcaac atcagctgcc ccaaccccct gcccttccgg      480

gagtaccggc cccagaccga gggcgtgagc aacctggtgg gcctgcccaa caacatctgc      540

ctgcagaaaa ccagcaacca gatcctgaag cccaagctga tctcctacac cctgcccgtg      600

gtgggccaga gcggcacctg catcaccgac cccctgctgg ccatggacga gggctacttc      660

gcctacagcc acctggagcg gatcggcagc tgcagccggg gagtgagcaa gcagcggatc      720

atcggcgtgg gcgaagtgct ggaccggggc gacgaagtgc ccagcctgtt catgaccaac      780

gtgtggaccc cccccaaccc caacaccgtg taccactgca gcgccgtgta caacaacgag      840

ttctactacg tgctgtgcgc cgtgagcacc gtgggcgacc ccatcctgaa cagcacctac      900

tggagcggca gcctgatgat gacccggctg gccgtgaagc ctaagagcaa cggcggaggc      960

tacaaccagc accagctggc cctgcggagc atcgagaagg gccggtacga caaagtgatg     1020

ccctacggcc ccagcggcat caagcagggc gacaccctgt acttccccgc cgtgggcttc     1080

ctggtgcgga ccgagttcaa gtacaacgac agcaactgcc ccatcaccaa gtgccagtac     1140

agcaagcccg agaactgccg gctgagcatg ggcatccggc ccaacagcca ctacatcctg     1200

cggagcggcc tgctgaagta caacctgagc gacggcgaga accccaaagt ggtgttcatc     1260

gagatcagcg accagagact gagcatcggc agccccagca agatctacga cagcctgggc     1320

cagcccgtgt tctaccaggc cagcttcagc tgggacacca tgatcaagtt cggcgacgtg     1380

ctgaccgtga accccctggt ggtgaactgg cggaacaata ccgtgatcag cagacccggc     1440

cagagccagt gcccccggtt caacacctgc cccgagatct gctgggaggg cgtgtacaac     1500

gacgccttcc tgatcgaccg gatcaactgg atcagcgccg gagtgttcct ggatagcaac     1560

cagaccgccg agaatcccgt gttcaccgtg tttaaggaca acgagatcct gtacagagcc     1620

cagctggcca gcgaggacac caacgcccag aaaaccatca ccaactgctt cctgctgaag     1680

aataagatct ggtgcatcag cctggtggag atctacgata ccggcgacaa cgtgatcagg     1740

cccaagctgt tcgccgtgaa gatccccgag cagtgctacc cctacgacgt gcccgactac     1800

gcctga                                                                1806


<210>  17
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  17

Met Gly Lys Gly Lys Ile Pro Ser Lys Val Ile Lys Ser Tyr Tyr Gly 
1               5                   10                  15      


Thr Met Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile 
            20                  25                  30          


Leu Ser Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile 
        35                  40                  45              


Ile Val Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp 
    50                  55                  60                  


Asn Gln Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile 
65                  70                  75                  80  


Lys Gly Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser 
                85                  90                  95      


Leu Ile Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu 
            100                 105                 110         


Leu Gly Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val 
        115                 120                 125             


Asn Glu Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys 
    130                 135                 140                 


Asn Ile Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln 
145                 150                 155                 160 


Thr Glu Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu 
                165                 170                 175     


Gln Lys Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr 
            180                 185                 190         


Leu Pro Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu 
        195                 200                 205             


Ala Met Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly 
    210                 215                 220                 


Ser Cys Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu 
225                 230                 235                 240 


Val Leu Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val 
                245                 250                 255     


Trp Thr Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr 
            260                 265                 270         


Asn Asn Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp 
        275                 280                 285             


Pro Ile Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg 
    290                 295                 300                 


Leu Ala Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln 
305                 310                 315                 320 


Leu Ala Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro 
                325                 330                 335     


Tyr Gly Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala 
            340                 345                 350         


Val Gly Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys 
        355                 360                 365             


Pro Ile Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser 
    370                 375                 380                 


Met Gly Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu 
385                 390                 395                 400 


Lys Tyr Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu 
                405                 410                 415     


Ile Ser Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp 
            420                 425                 430         


Ser Leu Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr 
        435                 440                 445             


Met Ile Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val Asn 
    450                 455                 460                 


Trp Arg Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro 
465                 470                 475                 480 


Arg Phe Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp 
                485                 490                 495     


Ala Phe Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu 
            500                 505                 510         


Asp Ser Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp 
        515                 520                 525             


Asn Glu Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala 
    530                 535                 540                 


Gln Lys Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys 
545                 550                 555                 560 


Ile Ser Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro 
                565                 570                 575     


Lys Leu Phe Ala Val Lys Ile Pro Glu Gln Cys Tyr Pro Tyr Asp Val 
            580                 585                 590         


Pro Asp Tyr Ala 
        595     


<210>  18
<211>  1791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  18
atgggaaagg gcaagatccc cagcaaagtg atcaagagct actacggcac catggacatc       60

aagaagatca acgagggcct gctggacagc aagatcctga gcgccttcaa caccgtgatc      120

gccctgctgg gcagcatcgt gatcattgtg atgaacatca tgatcatcca gaactacacc      180

cggagcaccg acaaccaggc cgtgatcaag gacgccctgc agggaatcca gcagcagatc      240

aagggcctgg ccgacaagat cggcaccgag atcggcccca aagtgagcct gatcgacacc      300

agcagcacca tcaccatccc cgccaacatc ggcctgctgg gatccaagat cagccagagc      360

accgccagca tcaacgagaa cgtgaacgag aagtgcaagt tcaccctgcc ccccctgaag      420

atccacgagt gcaacatcag ctgccccaac cccctgccct tccgggagta ccggccccag      480

accgagggcg tgagcaacct ggtgggcctg cccaacaaca tctgcctgca gaaaaccagc      540

aaccagatcc tgaagcccaa gctgatctcc tacaccctgc ccgtggtggg ccagagcggc      600

acctgcatca ccgaccccct gctggccatg gacgagggct acttcgccta cagccacctg      660

gagcggatcg gcagctgcag ccggggagtg agcaagcagc ggatcatcgg cgtgggcgaa      720

gtgctggacc ggggcgacga agtgcccagc ctgttcatga ccaacgtgtg gacccccccc      780

aaccccaaca ccgtgtacca ctgcagcgcc gtgtacaaca acgagttcta ctacgtgctg      840

tgcgccgtga gcaccgtggg cgaccccatc ctgaacagca cctactggag cggcagcctg      900

atgatgaccc ggctggccgt gaagcctaag agcaacggcg gaggctacaa ccagcaccag      960

ctggccctgc ggagcatcga gaagggccgg tacgacaaag tgatgcccta cggccccagc     1020

ggcatcaagc agggcgacac cctgtacttc cccgccgtgg gcttcctggt gcggaccgag     1080

ttcaagtaca acgacagcaa ctgccccatc accaagtgcc agtacagcaa gcccgagaac     1140

tgccggctga gcatgggcat ccggcccaac agccactaca tcctgcggag cggcctgctg     1200

aagtacaacc tgagcgacgg cgagaacccc aaagtggtgt tcatcgagat cagcgaccag     1260

agactgagca tcggcagccc cagcaagatc tacgacagcc tgggccagcc cgtgttctac     1320

caggccagct tcagctggga caccatgatc aagttcggcg acgtgctgac cgtgaacccc     1380

ctggtggtga actggcggaa caataccgtg atcagcagac ccggccagag ccagtgcccc     1440

cggttcaaca cctgccccga gatctgctgg gagggcgtgt acaacgacgc cttcctgatc     1500

gaccggatca actggatcag cgccggagtg ttcctggata gcaaccagac cgccgagaat     1560

cccgtgttca ccgtgtttaa ggacaacgag atcctgtaca gagcccagct ggccagcgag     1620

gacaccaacg cccagaaaac catcaccaac tgcttcctgc tgaagaataa gatctggtgc     1680

atcagcctgg tggagatcta cgataccggc gacaacgtga tcaggcccaa gctgttcgcc     1740

gtgaagatcc ccgagcagtg ctacccctac gacgtgcccg actacgcctg a              1791


<210>  19
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  19

Met Gly Ser Lys Val Ile Lys Ser Tyr Tyr Gly Thr Met Asp Ile Lys 
1               5                   10                  15      


Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys Ile Leu Ser Ala Phe Asn 
            20                  25                  30          


Thr Val Ile Ala Leu Leu Gly Ser Ile Val Ile Ile Val Met Asn Ile 
        35                  40                  45              


Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr Asp Asn Gln Ala Val Ile 
    50                  55                  60                  


Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln Ile Lys Gly Leu Ala Asp 
65                  70                  75                  80  


Lys Ile Gly Thr Glu Ile Gly Pro Lys Val Ser Leu Ile Asp Thr Ser 
                85                  90                  95      


Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly Leu Leu Gly Ser Lys Ile 
            100                 105                 110         


Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn Val Asn Glu Lys Cys Lys 
        115                 120                 125             


Phe Thr Leu Pro Pro Leu Lys Ile His Glu Cys Asn Ile Ser Cys Pro 
    130                 135                 140                 


Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro Gln Thr Glu Gly Val Ser 
145                 150                 155                 160 


Asn Leu Val Gly Leu Pro Asn Asn Ile Cys Leu Gln Lys Thr Ser Asn 
                165                 170                 175     


Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr Thr Leu Pro Val Val Gly 
            180                 185                 190         


Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu Leu Ala Met Asp Glu Gly 
        195                 200                 205             


Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile Gly Ser Cys Ser Arg Gly 
    210                 215                 220                 


Val Ser Lys Gln Arg Ile Ile Gly Val Gly Glu Val Leu Asp Arg Gly 
225                 230                 235                 240 


Asp Glu Val Pro Ser Leu Phe Met Thr Asn Val Trp Thr Pro Pro Asn 
                245                 250                 255     


Pro Asn Thr Val Tyr His Cys Ser Ala Val Tyr Asn Asn Glu Phe Tyr 
            260                 265                 270         


Tyr Val Leu Cys Ala Val Ser Thr Val Gly Asp Pro Ile Leu Asn Ser 
        275                 280                 285             


Thr Tyr Trp Ser Gly Ser Leu Met Met Thr Arg Leu Ala Val Lys Pro 
    290                 295                 300                 


Lys Ser Asn Gly Gly Gly Tyr Asn Gln His Gln Leu Ala Leu Arg Ser 
305                 310                 315                 320 


Ile Glu Lys Gly Arg Tyr Asp Lys Val Met Pro Tyr Gly Pro Ser Gly 
                325                 330                 335     


Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro Ala Val Gly Phe Leu Val 
            340                 345                 350         


Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn Cys Pro Ile Thr Lys Cys 
        355                 360                 365             


Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu Ser Met Gly Ile Arg Pro 
    370                 375                 380                 


Asn Ser His Tyr Ile Leu Arg Ser Gly Leu Leu Lys Tyr Asn Leu Ser 
385                 390                 395                 400 


Asp Gly Glu Asn Pro Lys Val Val Phe Ile Glu Ile Ser Asp Gln Arg 
                405                 410                 415     


Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr Asp Ser Leu Gly Gln Pro 
            420                 425                 430         


Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp Thr Met Ile Lys Phe Gly 
        435                 440                 445             


Asp Val Leu Thr Val Asn Pro Leu Val Val Asn Trp Arg Asn Asn Thr 
    450                 455                 460                 


Val Ile Ser Arg Pro Gly Gln Ser Gln Cys Pro Arg Phe Asn Thr Cys 
465                 470                 475                 480 


Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn Asp Ala Phe Leu Ile Asp 
                485                 490                 495     


Arg Ile Asn Trp Ile Ser Ala Gly Val Phe Leu Asp Ser Asn Gln Thr 
            500                 505                 510         


Ala Glu Asn Pro Val Phe Thr Val Phe Lys Asp Asn Glu Ile Leu Tyr 
        515                 520                 525             


Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn Ala Gln Lys Thr Ile Thr 
    530                 535                 540                 


Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp Cys Ile Ser Leu Val Glu 
545                 550                 555                 560 


Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg Pro Lys Leu Phe Ala Val 
                565                 570                 575     


Lys Ile Pro Glu Gln Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            580                 585                 590     


<210>  20
<211>  1776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  20
atgggaagca aagtgatcaa gagctactac ggcaccatgg acatcaagaa gatcaacgag       60

ggcctgctgg acagcaagat cctgagcgcc ttcaacaccg tgatcgccct gctgggcagc      120

atcgtgatca ttgtgatgaa catcatgatc atccagaact acacccggag caccgacaac      180

caggccgtga tcaaggacgc cctgcaggga atccagcagc agatcaaggg cctggccgac      240

aagatcggca ccgagatcgg ccccaaagtg agcctgatcg acaccagcag caccatcacc      300

atccccgcca acatcggcct gctgggatcc aagatcagcc agagcaccgc cagcatcaac      360

gagaacgtga acgagaagtg caagttcacc ctgccccccc tgaagatcca cgagtgcaac      420

atcagctgcc ccaaccccct gcccttccgg gagtaccggc cccagaccga gggcgtgagc      480

aacctggtgg gcctgcccaa caacatctgc ctgcagaaaa ccagcaacca gatcctgaag      540

cccaagctga tctcctacac cctgcccgtg gtgggccaga gcggcacctg catcaccgac      600

cccctgctgg ccatggacga gggctacttc gcctacagcc acctggagcg gatcggcagc      660

tgcagccggg gagtgagcaa gcagcggatc atcggcgtgg gcgaagtgct ggaccggggc      720

gacgaagtgc ccagcctgtt catgaccaac gtgtggaccc cccccaaccc caacaccgtg      780

taccactgca gcgccgtgta caacaacgag ttctactacg tgctgtgcgc cgtgagcacc      840

gtgggcgacc ccatcctgaa cagcacctac tggagcggca gcctgatgat gacccggctg      900

gccgtgaagc ctaagagcaa cggcggaggc tacaaccagc accagctggc cctgcggagc      960

atcgagaagg gccggtacga caaagtgatg ccctacggcc ccagcggcat caagcagggc     1020

gacaccctgt acttccccgc cgtgggcttc ctggtgcgga ccgagttcaa gtacaacgac     1080

agcaactgcc ccatcaccaa gtgccagtac agcaagcccg agaactgccg gctgagcatg     1140

ggcatccggc ccaacagcca ctacatcctg cggagcggcc tgctgaagta caacctgagc     1200

gacggcgaga accccaaagt ggtgttcatc gagatcagcg accagagact gagcatcggc     1260

agccccagca agatctacga cagcctgggc cagcccgtgt tctaccaggc cagcttcagc     1320

tgggacacca tgatcaagtt cggcgacgtg ctgaccgtga accccctggt ggtgaactgg     1380

cggaacaata ccgtgatcag cagacccggc cagagccagt gcccccggtt caacacctgc     1440

cccgagatct gctgggaggg cgtgtacaac gacgccttcc tgatcgaccg gatcaactgg     1500

atcagcgccg gagtgttcct ggatagcaac cagaccgccg agaatcccgt gttcaccgtg     1560

tttaaggaca acgagatcct gtacagagcc cagctggcca gcgaggacac caacgcccag     1620

aaaaccatca ccaactgctt cctgctgaag aataagatct ggtgcatcag cctggtggag     1680

atctacgata ccggcgacaa cgtgatcagg cccaagctgt tcgccgtgaa gatccccgag     1740

cagtgctacc cctacgacgt gcccgactac gcctga                               1776


<210>  21
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  21

Met Gly Ser Tyr Tyr Gly Thr Met Asp Ile Lys Lys Ile Asn Glu Gly 
1               5                   10                  15      


Leu Leu Asp Ser Lys Ile Leu Ser Ala Phe Asn Thr Val Ile Ala Leu 
            20                  25                  30          


Leu Gly Ser Ile Val Ile Ile Val Met Asn Ile Met Ile Ile Gln Asn 
        35                  40                  45              


Tyr Thr Arg Ser Thr Asp Asn Gln Ala Val Ile Lys Asp Ala Leu Gln 
    50                  55                  60                  


Gly Ile Gln Gln Gln Ile Lys Gly Leu Ala Asp Lys Ile Gly Thr Glu 
65                  70                  75                  80  


Ile Gly Pro Lys Val Ser Leu Ile Asp Thr Ser Ser Thr Ile Thr Ile 
                85                  90                  95      


Pro Ala Asn Ile Gly Leu Leu Gly Ser Lys Ile Ser Gln Ser Thr Ala 
            100                 105                 110         


Ser Ile Asn Glu Asn Val Asn Glu Lys Cys Lys Phe Thr Leu Pro Pro 
        115                 120                 125             


Leu Lys Ile His Glu Cys Asn Ile Ser Cys Pro Asn Pro Leu Pro Phe 
    130                 135                 140                 


Arg Glu Tyr Arg Pro Gln Thr Glu Gly Val Ser Asn Leu Val Gly Leu 
145                 150                 155                 160 


Pro Asn Asn Ile Cys Leu Gln Lys Thr Ser Asn Gln Ile Leu Lys Pro 
                165                 170                 175     


Lys Leu Ile Ser Tyr Thr Leu Pro Val Val Gly Gln Ser Gly Thr Cys 
            180                 185                 190         


Ile Thr Asp Pro Leu Leu Ala Met Asp Glu Gly Tyr Phe Ala Tyr Ser 
        195                 200                 205             


His Leu Glu Arg Ile Gly Ser Cys Ser Arg Gly Val Ser Lys Gln Arg 
    210                 215                 220                 


Ile Ile Gly Val Gly Glu Val Leu Asp Arg Gly Asp Glu Val Pro Ser 
225                 230                 235                 240 


Leu Phe Met Thr Asn Val Trp Thr Pro Pro Asn Pro Asn Thr Val Tyr 
                245                 250                 255     


His Cys Ser Ala Val Tyr Asn Asn Glu Phe Tyr Tyr Val Leu Cys Ala 
            260                 265                 270         


Val Ser Thr Val Gly Asp Pro Ile Leu Asn Ser Thr Tyr Trp Ser Gly 
        275                 280                 285             


Ser Leu Met Met Thr Arg Leu Ala Val Lys Pro Lys Ser Asn Gly Gly 
    290                 295                 300                 


Gly Tyr Asn Gln His Gln Leu Ala Leu Arg Ser Ile Glu Lys Gly Arg 
305                 310                 315                 320 


Tyr Asp Lys Val Met Pro Tyr Gly Pro Ser Gly Ile Lys Gln Gly Asp 
                325                 330                 335     


Thr Leu Tyr Phe Pro Ala Val Gly Phe Leu Val Arg Thr Glu Phe Lys 
            340                 345                 350         


Tyr Asn Asp Ser Asn Cys Pro Ile Thr Lys Cys Gln Tyr Ser Lys Pro 
        355                 360                 365             


Glu Asn Cys Arg Leu Ser Met Gly Ile Arg Pro Asn Ser His Tyr Ile 
    370                 375                 380                 


Leu Arg Ser Gly Leu Leu Lys Tyr Asn Leu Ser Asp Gly Glu Asn Pro 
385                 390                 395                 400 


Lys Val Val Phe Ile Glu Ile Ser Asp Gln Arg Leu Ser Ile Gly Ser 
                405                 410                 415     


Pro Ser Lys Ile Tyr Asp Ser Leu Gly Gln Pro Val Phe Tyr Gln Ala 
            420                 425                 430         


Ser Phe Ser Trp Asp Thr Met Ile Lys Phe Gly Asp Val Leu Thr Val 
        435                 440                 445             


Asn Pro Leu Val Val Asn Trp Arg Asn Asn Thr Val Ile Ser Arg Pro 
    450                 455                 460                 


Gly Gln Ser Gln Cys Pro Arg Phe Asn Thr Cys Pro Glu Ile Cys Trp 
465                 470                 475                 480 


Glu Gly Val Tyr Asn Asp Ala Phe Leu Ile Asp Arg Ile Asn Trp Ile 
                485                 490                 495     


Ser Ala Gly Val Phe Leu Asp Ser Asn Gln Thr Ala Glu Asn Pro Val 
            500                 505                 510         


Phe Thr Val Phe Lys Asp Asn Glu Ile Leu Tyr Arg Ala Gln Leu Ala 
        515                 520                 525             


Ser Glu Asp Thr Asn Ala Gln Lys Thr Ile Thr Asn Cys Phe Leu Leu 
    530                 535                 540                 


Lys Asn Lys Ile Trp Cys Ile Ser Leu Val Glu Ile Tyr Asp Thr Gly 
545                 550                 555                 560 


Asp Asn Val Ile Arg Pro Lys Leu Phe Ala Val Lys Ile Pro Glu Gln 
                565                 570                 575     


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            580                 585     


<210>  22
<211>  1761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  22
atgggaagct actacggcac catggacatc aagaagatca acgagggcct gctggacagc       60

aagatcctga gcgccttcaa caccgtgatc gccctgctgg gcagcatcgt gatcattgtg      120

atgaacatca tgatcatcca gaactacacc cggagcaccg acaaccaggc cgtgatcaag      180

gacgccctgc agggaatcca gcagcagatc aagggcctgg ccgacaagat cggcaccgag      240

atcggcccca aagtgagcct gatcgacacc agcagcacca tcaccatccc cgccaacatc      300

ggcctgctgg gatccaagat cagccagagc accgccagca tcaacgagaa cgtgaacgag      360

aagtgcaagt tcaccctgcc ccccctgaag atccacgagt gcaacatcag ctgccccaac      420

cccctgccct tccgggagta ccggccccag accgagggcg tgagcaacct ggtgggcctg      480

cccaacaaca tctgcctgca gaaaaccagc aaccagatcc tgaagcccaa gctgatctcc      540

tacaccctgc ccgtggtggg ccagagcggc acctgcatca ccgaccccct gctggccatg      600

gacgagggct acttcgccta cagccacctg gagcggatcg gcagctgcag ccggggagtg      660

agcaagcagc ggatcatcgg cgtgggcgaa gtgctggacc ggggcgacga agtgcccagc      720

ctgttcatga ccaacgtgtg gacccccccc aaccccaaca ccgtgtacca ctgcagcgcc      780

gtgtacaaca acgagttcta ctacgtgctg tgcgccgtga gcaccgtggg cgaccccatc      840

ctgaacagca cctactggag cggcagcctg atgatgaccc ggctggccgt gaagcctaag      900

agcaacggcg gaggctacaa ccagcaccag ctggccctgc ggagcatcga gaagggccgg      960

tacgacaaag tgatgcccta cggccccagc ggcatcaagc agggcgacac cctgtacttc     1020

cccgccgtgg gcttcctggt gcggaccgag ttcaagtaca acgacagcaa ctgccccatc     1080

accaagtgcc agtacagcaa gcccgagaac tgccggctga gcatgggcat ccggcccaac     1140

agccactaca tcctgcggag cggcctgctg aagtacaacc tgagcgacgg cgagaacccc     1200

aaagtggtgt tcatcgagat cagcgaccag agactgagca tcggcagccc cagcaagatc     1260

tacgacagcc tgggccagcc cgtgttctac caggccagct tcagctggga caccatgatc     1320

aagttcggcg acgtgctgac cgtgaacccc ctggtggtga actggcggaa caataccgtg     1380

atcagcagac ccggccagag ccagtgcccc cggttcaaca cctgccccga gatctgctgg     1440

gagggcgtgt acaacgacgc cttcctgatc gaccggatca actggatcag cgccggagtg     1500

ttcctggata gcaaccagac cgccgagaat cccgtgttca ccgtgtttaa ggacaacgag     1560

atcctgtaca gagcccagct ggccagcgag gacaccaacg cccagaaaac catcaccaac     1620

tgcttcctgc tgaagaataa gatctggtgc atcagcctgg tggagatcta cgataccggc     1680

gacaacgtga tcaggcccaa gctgttcgcc gtgaagatcc ccgagcagtg ctacccctac     1740

gacgtgcccg actacgcctg a                                               1761


<210>  23
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant peptide

<400>  23

Gly Thr Met Asp Ile Lys Lys Ile Asn Glu Gly Leu Leu Asp Ser Lys 
1               5                   10                  15      


Ile Leu Ser Ala Phe Asn Thr Val Ile Ala Leu Leu Gly Ser Ile Val 
            20                  25                  30          


Ile Ile Val Met Asn Ile Met Ile Ile Gln Asn Tyr Thr Arg Ser Thr 
        35                  40                  45              


Asp Asn Gln Ala Val Ile Lys Asp Ala Leu Gln Gly Ile Gln Gln Gln 
    50                  55                  60                  


Ile Lys Gly Leu Ala Asp Lys Ile Gly Thr Glu Ile Gly Pro Lys Val 
65                  70                  75                  80  


Ser Leu Ile Asp Thr Ser Ser Thr Ile Thr Ile Pro Ala Asn Ile Gly 
                85                  90                  95      


Leu Leu Gly Ser Lys Ile Ser Gln Ser Thr Ala Ser Ile Asn Glu Asn 
            100                 105                 110         


Val Asn Glu Lys Cys Lys Phe Thr Leu Pro Pro Leu Lys Ile His Glu 
        115                 120                 125             


Cys Asn Ile Ser Cys Pro Asn Pro Leu Pro Phe Arg Glu Tyr Arg Pro 
    130                 135                 140                 


Gln Thr Glu Gly Val Ser Asn Leu Val Gly Leu Pro Asn Asn Ile Cys 
145                 150                 155                 160 


Leu Gln Lys Thr Ser Asn Gln Ile Leu Lys Pro Lys Leu Ile Ser Tyr 
                165                 170                 175     


Thr Leu Pro Val Val Gly Gln Ser Gly Thr Cys Ile Thr Asp Pro Leu 
            180                 185                 190         


Leu Ala Met Asp Glu Gly Tyr Phe Ala Tyr Ser His Leu Glu Arg Ile 
        195                 200                 205             


Gly Ser Cys Ser Arg Gly Val Ser Lys Gln Arg Ile Ile Gly Val Gly 
    210                 215                 220                 


Glu Val Leu Asp Arg Gly Asp Glu Val Pro Ser Leu Phe Met Thr Asn 
225                 230                 235                 240 


Val Trp Thr Pro Pro Asn Pro Asn Thr Val Tyr His Cys Ser Ala Val 
                245                 250                 255     


Tyr Asn Asn Glu Phe Tyr Tyr Val Leu Cys Ala Val Ser Thr Val Gly 
            260                 265                 270         


Asp Pro Ile Leu Asn Ser Thr Tyr Trp Ser Gly Ser Leu Met Met Thr 
        275                 280                 285             


Arg Leu Ala Val Lys Pro Lys Ser Asn Gly Gly Gly Tyr Asn Gln His 
    290                 295                 300                 


Gln Leu Ala Leu Arg Ser Ile Glu Lys Gly Arg Tyr Asp Lys Val Met 
305                 310                 315                 320 


Pro Tyr Gly Pro Ser Gly Ile Lys Gln Gly Asp Thr Leu Tyr Phe Pro 
                325                 330                 335     


Ala Val Gly Phe Leu Val Arg Thr Glu Phe Lys Tyr Asn Asp Ser Asn 
            340                 345                 350         


Cys Pro Ile Thr Lys Cys Gln Tyr Ser Lys Pro Glu Asn Cys Arg Leu 
        355                 360                 365             


Ser Met Gly Ile Arg Pro Asn Ser His Tyr Ile Leu Arg Ser Gly Leu 
    370                 375                 380                 


Leu Lys Tyr Asn Leu Ser Asp Gly Glu Asn Pro Lys Val Val Phe Ile 
385                 390                 395                 400 


Glu Ile Ser Asp Gln Arg Leu Ser Ile Gly Ser Pro Ser Lys Ile Tyr 
                405                 410                 415     


Asp Ser Leu Gly Gln Pro Val Phe Tyr Gln Ala Ser Phe Ser Trp Asp 
            420                 425                 430         


Thr Met Ile Lys Phe Gly Asp Val Leu Thr Val Asn Pro Leu Val Val 
        435                 440                 445             


Asn Trp Arg Asn Asn Thr Val Ile Ser Arg Pro Gly Gln Ser Gln Cys 
    450                 455                 460                 


Pro Arg Phe Asn Thr Cys Pro Glu Ile Cys Trp Glu Gly Val Tyr Asn 
465                 470                 475                 480 


Asp Ala Phe Leu Ile Asp Arg Ile Asn Trp Ile Ser Ala Gly Val Phe 
                485                 490                 495     


Leu Asp Ser Asn Gln Thr Ala Glu Asn Pro Val Phe Thr Val Phe Lys 
            500                 505                 510         


Asp Asn Glu Ile Leu Tyr Arg Ala Gln Leu Ala Ser Glu Asp Thr Asn 
        515                 520                 525             


Ala Gln Lys Thr Ile Thr Asn Cys Phe Leu Leu Lys Asn Lys Ile Trp 
    530                 535                 540                 


Cys Ile Ser Leu Val Glu Ile Tyr Asp Thr Gly Asp Asn Val Ile Arg 
545                 550                 555                 560 


Pro Lys Leu Phe Ala Val Lys Ile Pro Glu Gln Cys Tyr Pro Tyr Asp 
                565                 570                 575     


Val Pro Asp Tyr Ala 
            580     


<210>  24
<211>  1746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant nucleotide

<400>  24
ggcaccatgg acatcaagaa gatcaacgag ggcctgctgg acagcaagat cctgagcgcc       60

ttcaacaccg tgatcgccct gctgggcagc atcgtgatca ttgtgatgaa catcatgatc      120

atccagaact acacccggag caccgacaac caggccgtga tcaaggacgc cctgcaggga      180

atccagcagc agatcaaggg cctggccgac aagatcggca ccgagatcgg ccccaaagtg      240

agcctgatcg acaccagcag caccatcacc atccccgcca acatcggcct gctgggatcc      300

aagatcagcc agagcaccgc cagcatcaac gagaacgtga acgagaagtg caagttcacc      360

ctgccccccc tgaagatcca cgagtgcaac atcagctgcc ccaaccccct gcccttccgg      420

gagtaccggc cccagaccga gggcgtgagc aacctggtgg gcctgcccaa caacatctgc      480

ctgcagaaaa ccagcaacca gatcctgaag cccaagctga tctcctacac cctgcccgtg      540

gtgggccaga gcggcacctg catcaccgac cccctgctgg ccatggacga gggctacttc      600

gcctacagcc acctggagcg gatcggcagc tgcagccggg gagtgagcaa gcagcggatc      660

atcggcgtgg gcgaagtgct ggaccggggc gacgaagtgc ccagcctgtt catgaccaac      720

gtgtggaccc cccccaaccc caacaccgtg taccactgca gcgccgtgta caacaacgag      780

ttctactacg tgctgtgcgc cgtgagcacc gtgggcgacc ccatcctgaa cagcacctac      840

tggagcggca gcctgatgat gacccggctg gccgtgaagc ctaagagcaa cggcggaggc      900

tacaaccagc accagctggc cctgcggagc atcgagaagg gccggtacga caaagtgatg      960

ccctacggcc ccagcggcat caagcagggc gacaccctgt acttccccgc cgtgggcttc     1020

ctggtgcgga ccgagttcaa gtacaacgac agcaactgcc ccatcaccaa gtgccagtac     1080

agcaagcccg agaactgccg gctgagcatg ggcatccggc ccaacagcca ctacatcctg     1140

cggagcggcc tgctgaagta caacctgagc gacggcgaga accccaaagt ggtgttcatc     1200

gagatcagcg accagagact gagcatcggc agccccagca agatctacga cagcctgggc     1260

cagcccgtgt tctaccaggc cagcttcagc tgggacacca tgatcaagtt cggcgacgtg     1320

ctgaccgtga accccctggt ggtgaactgg cggaacaata ccgtgatcag cagacccggc     1380

cagagccagt gcccccggtt caacacctgc cccgagatct gctgggaggg cgtgtacaac     1440

gacgccttcc tgatcgaccg gatcaactgg atcagcgccg gagtgttcct ggatagcaac     1500

cagaccgccg agaatcccgt gttcaccgtg tttaaggaca acgagatcct gtacagagcc     1560

cagctggcca gcgaggacac caacgcccag aaaaccatca ccaactgctt cctgctgaag     1620

aataagatct ggtgcatcag cctggtggag atctacgata ccggcgacaa cgtgatcagg     1680

cccaagctgt tcgccgtgaa gatccccgag cagtgctacc cctacgacgt gcccgactac     1740

gcctga                                                                1746


