                         SEQUENCE LISTING

<110>  VIOLETTE, Shelia
       SHEPPARD, Dean
 
<120>  BIOMARKERS FOR USE IN INTEGRIN THERAPY APPLICATIONS

<130>  13751-0138WO1

<160>  1211 

<170>  PatentIn version 3.5

<210>  1
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  1
gggctccacg gagtgaatag gaggcggctc aggcttcctg gctcgcgtgg gcgccagaaa       60

gcggaacctc ccgggccagt cgcgcggtgg tcaccctctt gggagctggg gaggaggctg      120

cggaggctgg cccggctcct tcgggcgtcg cttcccggac cgggtgcgcg gggtcccccg      180

gaacgtgtgt tccaggtcct cccgcgccag tgttcgcagt ccccgcctgg tcgcggcggc      240

gcctcgggcg cgggtgcagg cgcgcggcgc gcaggcgggg ggcgctgtgg tcttggcgcg      300

gggaccgagc cgctcggcca gacccgcctc ttttccctcc ccgccagccc gcccgcctgc      360

ccgcccccca cgcgtcgtgt cgccgggaag ccgggcggag acagagcgct tgggatccac      420

ggcgctcgga ccgctgtcct ccaacagcgc agggcagagc ggctggcgcc gccggagcgc      480

ggagccacga ccctccctgg ccgcctttgt ctactggccg tgcggcccgg aaccgccact      540

ctccagggcc ggggacgcgc ccgcagctgt cggtgacagc tcctccctac cgcaaccctc      600

cggggcggag gggcggtcgg gccgggccct gctagcccgc gaccgcaagc ccgcgctcgc      660

ggatcgatgc ccccgcagca gggggacccc gcgttccccg accgctgcga ggcgcctccg      720

gtgccgccgc gtcgggagcg cggtggacgc gggggacgcg ggcctgggga gccggggggc      780

cgggggcgtg cggggggtgc cgaggggcgc ggcgtcaagt gcgtgctggt cggcgacggc      840

gcggtgggca agacgagcct ggtggtgagc tacaccacca acggctaccc caccgagtac      900

atccctactg ccttcgacaa cttctccgcg gtggtgtctg tggatgggcg gcccgtgaga      960

ctccaactct gtgacactgc cggacaggat gaatttgaca agctgaggcc tctctgctac     1020

accaacacag acatcttcct gctctgcttc agtgtcgtga gcccctcatc cttccagaac     1080

gtcagtgaga aatgggtgcc ggagattcga tgccactgtc ccaaagcccc catcatccta     1140

gttggaacgc agtcggatct cagagaagat gtcaaagtcc tcattgagtt ggacaaatgc     1200

aaagaaaagc cagtgcctga agaggcggct aagctgtgcg ccgaggaaat caaagccgcc     1260

tcctacatcg agtgttcagc cttgactcaa aaaaacctca aagaggtctt tgatgcagcc     1320

atcgtcgctg gcattcaata ctcggacact cagcaacagc caaagaagtc taaaagcagg     1380

actccagata aaatgaaaaa cctctccaag tcctggtgga agaagtactg ctgtttcgta     1440

tgatgctggc aagacaccca gaaaggctat tttcagatga aatcgatatt agaagctata     1500

ttagctgaaa caactccttt tactgcgtag aacctatatc gagagtgtgt gtatatgtat     1560

tataggagga gctctcaatt ttatgtattc tttctgcctt taattttctt gtttgtttga     1620

gcttagggat gagatactta tgcaagatat ttttgaagta aattaaacat ttttcacatc     1680

tctggaaatt tagagttcta gacctctggt taatttatat ctaatatgaa gaagacacct     1740

ctaatctgga tgttaagaat gaagttctgc tacattataa tgtacagaag agcaaaaggg     1800

aggaacacta tggttaaccc tctcttgatt aagggctact taatgcacag tgcattatgt     1860

acacaggtca accatggtaa caatagttct tagctttgaa actccatgca aaccatgcct     1920

tttttttaag gagcaaaaat ctgagaaaaa aagtgagaga cctctgccta caaaacctca     1980

aaccagtcac ttttgtcaat tgctaatacc cagttactta tgatttaaaa acaaccaaca     2040

gaaaacatcc cactgactgt atggcactct gtagtcaaaa aaggaaactt ccttattggg     2100

acttttcttt cttagtccag ttgtgttgac acatatgaac acagacaaag tgctatgcgg     2160

aggaaagcaa gtgttggtca gtagtttcat gttttaggga gtggttcctg tggagatcag     2220

aaagtgacat ttgctttcgg tactgtaata cgtgcaccaa actgcctcaa tcctaggtaa     2280

cgagggcaac agggagcacc tgtctggatt gtttttaaac ctccatactc aagctgtctc     2340

ttcggcaggg aggtgaatac tcttgaaagg ccaacagcaa gtgtttgtgg gacacaacac     2400

agataatttt ttcttaagtc ggccaagatg tacttctctg tgtgcacacc catgcacact     2460

catgcacaca gatacatagg tctgtatggc tgtatttgct gttgattcag actttcacac     2520

cattaatggg gaaaagcgtg gccacaaaaa cagatgctag gaagcttggc ttcctcttct     2580

tgttgaccct tttttgaacc aacatctttt ttattatatt cagagtatgt ttttaagtgt     2640

atcttaatat atacattttt taggacatct taaatctaaa caaaaaataa aatgaacatc     2700

tcttgaaacc tgttaaaaca accagttaaa gccacagatg gctttcaggg cagtagcagc     2760

agaggccagt ggactctgag gactcctgag gggcggggcg tgtagccagc caggtgcatg     2820

ccgggaccat ggcccccata cttggctgct tcctgtgaca gtgaaataca tccttcaagg     2880

tggcagctgt tagggctgaa tcttctggag aaaaaggtgc catctcagga gaatagcttt     2940

tactctggta ggaatgcttc cgagacacca caaggcagcc tgaacactca gttgcagggt     3000

cgggcttgcg gtgggtgacc cagagccacc aaagtcacat ccacaactaa tgagggaaat     3060

ctgtaaagcc agttagatag aagaatttta tttttctgtg ggttttgtgt tgtctttttt     3120

atgttaaaaa gaaatccagt ttgtgttttt ctatagaaaa agtaaaagat caggttatac     3180

tttaggttag gggttctatt tattcctgtt agtaaataaa attaacaaat ttctttgttt     3240

aacaaaagat taatctttaa accactaaaa tacatagact gattgattat tcaacacatt     3300

ggaattgatg tcggtcatag tttcctgaag catttagtta caacctgaag gaataaaatg     3360

atttgtggaa atgcttaaaa tagacctaac tgaatacagt ctcatcttgc cgcgcctggc     3420

ttacctatct gtggaaagct aggcttccca ggctgggctc tgcctgtctg gtgcctggag     3480

gtgtgggagg gaagatgagt tatttaactg gtaagcgatt tgaaacacta tttttatatt     3540

aaagtaaatg gcatggagta tagtgcaaat tcatttttaa gatagaacac aaaacttgaa     3600

agaagtttta tgcgtgtgac agtgtatggg gctgcagttg gtctccctgg aggggacttc     3660

cacacctcct gcctttaggc catgggtgga aagtgctcag tgaagtacac ctgtgtggcc     3720

cagttctgaa agctttatac agttgaattt taagtggggt tgataacacc ttggactgtt     3780

agtgttaaaa atctagtggg ttgaccttta aatgcaacag tttttaaaat atattgctgc     3840

attttataga atagtaaagg tacgattata cttgagattt tcctccattt ttatttcttc     3900

gtgaacatag agtttggggc cgaaaatgtt tttaaagtat gtgtttgagt taaatataaa     3960

gttggttcac ttcaaagcta aaaaattgtt aaacttgcag cttggtattg cagagaagat     4020

tttataagaa ttttgcttta gagaatgcca ctttggctga actacaagtg taggccacca     4080

ttataattta taaatacagc atacttcaaa actgtttgtt atctcttgtt accatgtatg     4140

tataaatgga ccttttataa ccttgttctc tgcttgacag actcaagaga aactacccag     4200

gtattacaca agccaaaatg ggagcaaggc cttctctcca gactatcgta acctggtgcc     4260

ttaccaagtt gtgcttttct gttttcaagt gtaaatgatg ttgagcagaa tgttgtactt     4320

gaaaatgcta taagtgagat ggtatgaaat aaattctgac ttatgaatat aaaaaaaaaa     4380

aaaaaa                                                                4386


<210>  2
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Pro Gln Gln Gly Asp Pro Ala Phe Pro Asp Arg Cys Glu Ala 
1               5                   10                  15      


Pro Pro Val Pro Pro Arg Arg Glu Arg Gly Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Pro Gly Glu Pro Gly Gly Arg Gly Arg Ala Gly Gly Ala Glu Gly Arg 
        35                  40                  45              


Gly Val Lys Cys Val Leu Val Gly Asp Gly Ala Val Gly Lys Thr Ser 
    50                  55                  60                  


Leu Val Val Ser Tyr Thr Thr Asn Gly Tyr Pro Thr Glu Tyr Ile Pro 
65                  70                  75                  80  


Thr Ala Phe Asp Asn Phe Ser Ala Val Val Ser Val Asp Gly Arg Pro 
                85                  90                  95      


Val Arg Leu Gln Leu Cys Asp Thr Ala Gly Gln Asp Glu Phe Asp Lys 
            100                 105                 110         


Leu Arg Pro Leu Cys Tyr Thr Asn Thr Asp Ile Phe Leu Leu Cys Phe 
        115                 120                 125             


Ser Val Val Ser Pro Ser Ser Phe Gln Asn Val Ser Glu Lys Trp Val 
    130                 135                 140                 


Pro Glu Ile Arg Cys His Cys Pro Lys Ala Pro Ile Ile Leu Val Gly 
145                 150                 155                 160 


Thr Gln Ser Asp Leu Arg Glu Asp Val Lys Val Leu Ile Glu Leu Asp 
                165                 170                 175     


Lys Cys Lys Glu Lys Pro Val Pro Glu Glu Ala Ala Lys Leu Cys Ala 
            180                 185                 190         


Glu Glu Ile Lys Ala Ala Ser Tyr Ile Glu Cys Ser Ala Leu Thr Gln 
        195                 200                 205             


Lys Asn Leu Lys Glu Val Phe Asp Ala Ala Ile Val Ala Gly Ile Gln 
    210                 215                 220                 


Tyr Ser Asp Thr Gln Gln Gln Pro Lys Lys Ser Lys Ser Arg Thr Pro 
225                 230                 235                 240 


Asp Lys Met Lys Asn Leu Ser Lys Ser Trp Trp Lys Lys Tyr Cys Cys 
                245                 250                 255     


Phe Val 
        


<210>  3
<211>  2369
<212>  DNA
<213>  Homo sapiens

<400>  3
ccaagcgcgc ggggcaaggc ggccctgcag gggtgagctt tcctctgaga acccggggcc       60

ttagcgacac gtaatccagt tttccgtctc cttggtgcag atgaagaaac cgacgcccat      120

gggcgaaagg gacctgctca agttcactca gtaagtcagg agataagcca gaatgcgtat      180

ctgactccag tctcaatgtc taccccttca caaaacggta gcctccaggg tagtcctcag      240

caaagcgttg gcaccttact gaatctgttt ttccatctga gaaatgggcc aacggaaaaa      300

tcaaacttcc attctgggga agtcgagaac cgggactccc taggaagggc agtgctttgg      360

cctcatgttc tgtgctctga cagagagctg cactagagac aagtttatcc atgaacacat      420

tgctctgtaa aggaatgttt tgcctactca gctgggaggc cgacagcaga ggcagacttg      480

gggagtacac tctgcagccc ctgtccctgc agactgaaga gaccacagag ctgggcagca      540

agaaggagct caagtccatg cccttcatca cctacctctc aggtttgctg acagcccaga      600

tgctgtcaga tgaccagctc atttcaggtg tggagattcg ctgtgaggag aaggggcgct      660

gtccatctac ctgtcacctt tgccgccggc caggcaagga gcagctgagc cccacaccag      720

tgctgctgga aatcaaccgt gtggtgccac tttataccct catccaagac aatggcacaa      780

aggaggcctt caagagtgca ctgatgagtt cctactggtg ctcagggaaa ggggatgtga      840

tcgatgactg gtgcaggtgt gacctcagcg cctttgatgc caatgggctc cccaactgca      900

gcccccttct gcagccggtg ctgcggctgt ccccaacagt ggagccctcc agtactgtgg      960

tctccttgga gtgggtggat gttcagccag ctattgggac caaggtctcc gactatattc     1020

tgcagcataa gaaagtggat gaatacacag acactgacct gtacacagga gaattcctga     1080

gttttgctga tgacttactc tctggcctgg gcacatcttg tgtagcagct ggtcgaagcc     1140

atggagaggt ccctgaagtc agtatctact cagtcatctt caagtgtctg gagcccgacg     1200

gtctctacaa gttcactctg tatgctgtgg atacacgagg gaggcactca gagctaagca     1260

cggtgaccct gaggacggcc tgtccactgg tagatgacaa caaggcagaa gaaatagctg     1320

acaagatcta caatctgtac aatgggtaca caagtggaaa ggagcagcag atggcctaca     1380

acacactgat ggaggtctca gcctcgatgc tgttccgagt ccagcaccac tacaactctc     1440

actatgaaaa gtttggcgac ttcgtctgga gaagtgagga tgagctgggg cccaggaagg     1500

cccacctgat tctacggcga ctggagaggg tgagtagcca ctgctccagc ctcctgcgga     1560

gtgcctacat ccagagccgc gtggaaacag tgccctatct tttctgccgc agcgaggagg     1620

tccggcctgc aggcatggtg tggtatagca tcctcaagga caccaaaatc acgtgtgagg     1680

agaagatggt gtcaatggcc cgaaacacgt acggggagtc caagggccgg tgagggaggg     1740

tattgccctc cgtgagcaca gagactctcc atgggagggg gagcagtatt ctcctggatc     1800

ctggggcctg ggtgggctgg gggacagctg aggatgggcc tagcagatga agcttgccag     1860

caaggccaaa gcaaacggtt tctcctgtgg atagtggaca gagacctttg taaccaatgg     1920

aattattcat ttttctctat cttttatttt ttcaaagata ttatttgact ctatcaaaag     1980

tctctccttt ttaaaccttt tcttatggat ggctgtcaat cccgaggcag aagttttcag     2040

gtggagacca agcggccttt gctcttcttc cttcttcctg ccacactctg ctttcttcct     2100

gccatggacc cctggaggag acctatggag ggacagtttt gacctgaccc ctagaggaga     2160

cagttttgac ctcttcagca ccaggaagga agctctgagg atggttgcag tgaggaagca     2220

tgggtcttta aggacttctc tctctttttt gctggacatt attgagtttg tgggaccctg     2280

cctcttcctg ctacctgtgg gtctgcccag agtccctgca ggcctgtcca tgcattaaaa     2340

attcctattg tctctcttta aaaaaaaaa                                       2369


<210>  4
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Thr Leu Leu Cys Lys Gly Met Phe Cys Leu Leu Ser Trp Glu 
1               5                   10                  15      


Ala Asp Ser Arg Gly Arg Leu Gly Glu Tyr Thr Leu Gln Pro Leu Ser 
            20                  25                  30          


Leu Gln Thr Glu Glu Thr Thr Glu Leu Gly Ser Lys Lys Glu Leu Lys 
        35                  40                  45              


Ser Met Pro Phe Ile Thr Tyr Leu Ser Gly Leu Leu Thr Ala Gln Met 
    50                  55                  60                  


Leu Ser Asp Asp Gln Leu Ile Ser Gly Val Glu Ile Arg Cys Glu Glu 
65                  70                  75                  80  


Lys Gly Arg Cys Pro Ser Thr Cys His Leu Cys Arg Arg Pro Gly Lys 
                85                  90                  95      


Glu Gln Leu Ser Pro Thr Pro Val Leu Leu Glu Ile Asn Arg Val Val 
            100                 105                 110         


Pro Leu Tyr Thr Leu Ile Gln Asp Asn Gly Thr Lys Glu Ala Phe Lys 
        115                 120                 125             


Ser Ala Leu Met Ser Ser Tyr Trp Cys Ser Gly Lys Gly Asp Val Ile 
    130                 135                 140                 


Asp Asp Trp Cys Arg Cys Asp Leu Ser Ala Phe Asp Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Asn Cys Ser Pro Leu Leu Gln Pro Val Leu Arg Leu Ser Pro Thr 
                165                 170                 175     


Val Glu Pro Ser Ser Thr Val Val Ser Leu Glu Trp Val Asp Val Gln 
            180                 185                 190         


Pro Ala Ile Gly Thr Lys Val Ser Asp Tyr Ile Leu Gln His Lys Lys 
        195                 200                 205             


Val Asp Glu Tyr Thr Asp Thr Asp Leu Tyr Thr Gly Glu Phe Leu Ser 
    210                 215                 220                 


Phe Ala Asp Asp Leu Leu Ser Gly Leu Gly Thr Ser Cys Val Ala Ala 
225                 230                 235                 240 


Gly Arg Ser His Gly Glu Val Pro Glu Val Ser Ile Tyr Ser Val Ile 
                245                 250                 255     


Phe Lys Cys Leu Glu Pro Asp Gly Leu Tyr Lys Phe Thr Leu Tyr Ala 
            260                 265                 270         


Val Asp Thr Arg Gly Arg His Ser Glu Leu Ser Thr Val Thr Leu Arg 
        275                 280                 285             


Thr Ala Cys Pro Leu Val Asp Asp Asn Lys Ala Glu Glu Ile Ala Asp 
    290                 295                 300                 


Lys Ile Tyr Asn Leu Tyr Asn Gly Tyr Thr Ser Gly Lys Glu Gln Gln 
305                 310                 315                 320 


Met Ala Tyr Asn Thr Leu Met Glu Val Ser Ala Ser Met Leu Phe Arg 
                325                 330                 335     


Val Gln His His Tyr Asn Ser His Tyr Glu Lys Phe Gly Asp Phe Val 
            340                 345                 350         


Trp Arg Ser Glu Asp Glu Leu Gly Pro Arg Lys Ala His Leu Ile Leu 
        355                 360                 365             


Arg Arg Leu Glu Arg Val Ser Ser His Cys Ser Ser Leu Leu Arg Ser 
    370                 375                 380                 


Ala Tyr Ile Gln Ser Arg Val Glu Thr Val Pro Tyr Leu Phe Cys Arg 
385                 390                 395                 400 


Ser Glu Glu Val Arg Pro Ala Gly Met Val Trp Tyr Ser Ile Leu Lys 
                405                 410                 415     


Asp Thr Lys Ile Thr Cys Glu Glu Lys Met Val Ser Met Ala Arg Asn 
            420                 425                 430         


Thr Tyr Gly Glu Ser Lys Gly Arg 
        435                 440 


<210>  5
<211>  2123
<212>  DNA
<213>  homo sapiens

<400>  5
agagagaggg acgcgagcgg gatccaaact tccggtgcct gcagagctcg gagcggcgga       60

ggcagagacc gaggctgcac cggcagaggc tgcggggcgg acgcgcgggc cggcgcagcc      120

atggtgaaga ttagcttcca gcccgccgtg gctggcatca agggcgacaa ggctgacaag      180

gcgtcggcgt cggcccctgc gccggcctcg gccaccgaga tcctgctgac gccggctagg      240

gaggagcagc ccccacaaca tcgatccaag agggggggct cagtgggcgg cgtgtgctac      300

ctgtcgatgg gcatggtcgt gctgctcatg ggcctcgtgt tcgcctctgt ctacatctac      360

agatacttct tccttgcgca gctggcccga gataacttct tccgctgtgg tgtgctgtat      420

gaggactccc tgtcctccca ggtccggact cagatggagc tggaagagga tgtgaaaatc      480

tacctcgacg agaactacga gcgcatcaac gtgcctgtgc cccagtttgg cggcggtgac      540

cctgcagaca tcatccatga cttccagcgg ggtctgactg cgtaccatga tatctccctg      600

gacaagtgct atgtcatcga actcaacacc accattgtgc tgccccctcg caacttctgg      660

gagctcctca tgaacgtgaa gagggggacc tacctgccgc agacgtacat catccaggag      720

gagatggtgg tcacggagca tgtcagtgac aaggaggccc tggggtcctt catctaccac      780

ctgtgcaacg ggaaagacac ctaccggctc cggcgccggg caacgcggag gcggatcaac      840

aagcgtgggg ccaagaactg caatgccatc cgccacttcg agaacacctt cgtggtggag      900

acgctcatct gcggggtggt gtgaggccct cctcccccag aaccccctgc cgtgttcctc      960

ttttcttctt tccggctgct ctctggccct cctccttccc cctgcttagc ttgtactttg     1020

gacgcgtttc tatagaggtg acatgtctct ccattcctct ccaaccctgc ccacctccct     1080

gtaccagagc tgtgatctct cggtgggggg cccatctctg ctgacctggg tgtggcggag     1140

ggagaggcga tgctgcaaag tgttttctgt gtcccactgt cttgaagctg ggcctgccaa     1200

agcctgggcc cacagctgca ccggcagccc aaggggaagg accggttggg ggagccgggc     1260

atgtgaggcc ctgggcaagg ggatggggct gtgggggcgg ggcggcatgg gcttcagaag     1320

tatctgcaca attagaaaag tcctcagaag ctttttcttg gagggtacac tttcttcact     1380

gtccctattc ctagacctgg ggcttgagct gaggatggga cgatgtgccc agggagggac     1440

ccaccagagc acaagagaag gtggctacct gggggtgtcc cagggactct gtcagtgcct     1500

tcagcccacc agcaggagct tggagtttgg ggagtgggga tgagtccgtc aagcacaact     1560

gttctctgag tggaaccaaa gaagcaagga gctaggaccc ccagtcctgc cccccaggag     1620

cacaagcagg gtcccctcag tcaaggcagt gggatgggcg gctgaggaac ggggcaggca     1680

aggtcactgc tcagtcacgt ccacggggga cgagccgtgg gttctgctga gtaggtggag     1740

ctcattgctt tctccaagct tggaactgtt ttgaaagata acacagaggg aaagggagag     1800

ccacctggta cttgtccacc ctgcctcctc tgttctgaaa ttccatcccc ctcagcttag     1860

gggaatgcac ctttttccct ttccttctca cttttgcatg tttttactga tcattcgata     1920

tgctaaccgt tctcagccct gagccttgga gaggagggct gtaacgcctt cagtcagtct     1980

ctggggatga aactcttaaa tgctttgtat attttctcaa ttagatctct tttcagaagt     2040

gtctatagaa caataaaaat cttttacttc tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaa                                             2123


<210>  6
<211>  267
<212>  PRT
<213>  homo sapiens

<400>  6

Met Val Lys Ile Ser Phe Gln Pro Ala Val Ala Gly Ile Lys Gly Asp 
1               5                   10                  15      


Lys Ala Asp Lys Ala Ser Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr 
            20                  25                  30          


Glu Ile Leu Leu Thr Pro Ala Arg Glu Glu Gln Pro Pro Gln His Arg 
        35                  40                  45              


Ser Lys Arg Gly Gly Ser Val Gly Gly Val Cys Tyr Leu Ser Met Gly 
    50                  55                  60                  


Met Val Val Leu Leu Met Gly Leu Val Phe Ala Ser Val Tyr Ile Tyr 
65                  70                  75                  80  


Arg Tyr Phe Phe Leu Ala Gln Leu Ala Arg Asp Asn Phe Phe Arg Cys 
                85                  90                  95      


Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln Met 
            100                 105                 110         


Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg 
        115                 120                 125             


Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile 
    130                 135                 140                 


Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser Leu 
145                 150                 155                 160 


Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro Pro 
                165                 170                 175     


Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr Leu 
            180                 185                 190         


Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His Val 
        195                 200                 205             


Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn Gly 
    210                 215                 220                 


Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn 
225                 230                 235                 240 


Lys Arg Gly Ala Lys Asn Cys Asn Ala Ile Arg His Phe Glu Asn Thr 
                245                 250                 255     


Phe Val Val Glu Thr Leu Ile Cys Gly Val Val 
            260                 265         


<210>  7
<211>  2047
<212>  DNA
<213>  homo sapiens

<400>  7
gaacaaacgg gatattcagc agtggcctgt ggctgccaga gcagctcctc aggggaaact       60

aagcgtcgag tcagacggca ccataatcgc ctttaaaagt gcctccgccc tgccggccgc      120

gtatcccccg gctacctggg ccgccccgcg gcggtgcgcg cgtgagaggg agcgcgcggg      180

cagccgagcg ccggtgtgag ccagcgctgc tgccagtgtg agcggcggtg tgagcgcggt      240

gggtgcggag gggcgtgtgt gccggcgcgc gcgccgtggg gtgcaaaccc cgagcgtcta      300

cgctgccatg aggggcgcga acgcctgggc gccactctgc ctgctgctgg ctgccgccac      360

ccagctctcg cggcagcagt ccccagagag acctgttttc acatgtggtg gcattcttac      420

tggagagtct ggatttattg gcagtgaagg ttttcctgga gtgtaccctc caaatagcaa      480

atgtacttgg aaaatcacag ttcccgaagg aaaagtagtc gttctcaatt tccgattcat      540

agacctcgag agtgacaacc tgtgccgcta tgactttgtg gatgtgtaca atggccatgc      600

caatggccag cgcattggcc gcttctgtgg cactttccgg cctggagccc ttgtgtccag      660

tggcaacaag atgatggtgc agatgatttc tgatgccaac acagctggca atggcttcat      720

ggccatgttc tccgctgctg aaccaaacga aagaggggat cagtattgtg gaggactcct      780

tgacagacct tccggctctt ttaaaacccc caactggcca gaccgggatt accctgcagg      840

agtcacttgt gtgtggcaca ttgtagcccc aaagaatcag cttatagaat taaagtttga      900

gaagtttgat gtggagcgag ataactactg ccgatatgat tatgtggctg tgtttaatgg      960

cggggaagtc aacgatgcta gaagaattgg aaagtattgt ggtgatagtc cacctgcgcc     1020

aattgtgtct gagagaaatg aacttcttat tcagttttta tcagacttaa gtttaactgc     1080

agatgggttt attggtcact acatattcag gccaaaaaaa ctgcctacaa ctacagaaca     1140

gcctgtcacc accacattcc ctgtaaccac gggtttaaaa cccaccgtgg ccttgtgtca     1200

acaaaagtgt agacggacgg ggactctgga gggcaattat tgttcaagtg actttgtatt     1260

agccggcact gttatcacaa ccatcactcg cgatgggagt ttgcacgcca cagtctcgat     1320

catcaacatc tacaaagagg gaaatttggc gattcagcag gcgggcaaga acatgagtgc     1380

caggctgact gtcgtctgca agcagtgccc tctcctcaga agaggtctaa attacattat     1440

tatgggccaa gtaggtgaag atgggcgagg caaaatcatg ccaaacagct ttatcatgat     1500

gttcaagacc aagaatcaga agctcctgga tgccttaaaa aataagcaat gttaacagtg     1560

aactgtgtcc atttaagctg tattctgcca ttgcctttga aagatctatg ttctctcagt     1620

agaaaaaaaa atacttataa aattacatat tctgaaagag gattccgaaa gatgggactg     1680

gttgactctt cacatgatgg aggtatgagg cctccgagat agctgaggga agttctttgc     1740

ctgctgtcag aggagcagct atctgattgg aaacctgccg acttagtgcg gtgataggaa     1800

gctaaaagtg tcaagcgttg acagcttgga agcgtttatt tatacatctc tgtaaaagga     1860

tattttagaa ttgagttgtg tgaagatgtc aaaaaaagat tttagaagtg caatatttat     1920

agtgttattt gtttcacctt caagcctttg ccctgaggtg ttacaatctt gtcttgcgtt     1980

ttctaaatca atgcttaata aaatattttt aaaggattac agaacaacca aaaaaaaaaa     2040

aaaaaaa                                                               2047


<210>  8
<211>  415
<212>  PRT
<213>  homo sapiens

<400>  8

Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe Thr 
            20                  25                  30          


Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu Gly 
        35                  40                  45              


Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile Thr 
    50                  55                  60                  


Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp Leu 
65                  70                  75                  80  


Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn Gly 
                85                  90                  95      


His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg Pro 
            100                 105                 110         


Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile Ser 
        115                 120                 125             


Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala Ala 
    130                 135                 140                 


Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp Arg 
145                 150                 155                 160 


Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr Pro 
                165                 170                 175     


Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln Leu 
            180                 185                 190         


Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr Cys 
        195                 200                 205             


Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp Ala 
    210                 215                 220                 


Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Pro Ile Val 
225                 230                 235                 240 


Ser Glu Arg Asn Glu Leu Leu Ile Gln Phe Leu Ser Asp Leu Ser Leu 
                245                 250                 255     


Thr Ala Asp Gly Phe Ile Gly His Tyr Ile Phe Arg Pro Lys Lys Leu 
            260                 265                 270         


Pro Thr Thr Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr Thr 
        275                 280                 285             


Gly Leu Lys Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg Thr 
    290                 295                 300                 


Gly Thr Leu Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala Gly 
305                 310                 315                 320 


Thr Val Ile Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr Val 
                325                 330                 335     


Ser Ile Ile Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln Ala 
            340                 345                 350         


Gly Lys Asn Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys Pro 
        355                 360                 365             


Leu Leu Arg Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly Glu 
    370                 375                 380                 


Asp Gly Arg Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe Lys 
385                 390                 395                 400 


Thr Lys Asn Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 
                405                 410                 415 


<210>  9
<211>  3309
<212>  DNA
<213>  homo sapiens

<400>  9
ggcggagaga ataaagcaga aagacaggaa gaggaggtgg agttctacag ttagtgtggt       60

tttagttttt cctaagaagt ggcgtggttt ggggctttat atccgggagg agcatatgta      120

cgcaaatcct ggggcgtttg caaacccgga tccggggcgt ctggccccat gcccggccgg      180

gcgtttgagg gctactgcca cgcagcgttt ctggagcctg ccggctggtg ccctggtggc      240

ctttatctct gtcccccttt gtcctcttta tctcaggctc tccaggaggc cggggggccc      300

actccgccta tcgctcccct cggctacgct gccacttcaa tgccccgcag gtcgcgagct      360

gctgttcttt cgaaggcgtc ggagaaccag gggcgtcccg cgccacctct gactcggagc      420

agcgccgagc actgacgctc ccgcccttgg gcaaggacgc cagtgcgccc gcgcgcgtcc      480

ctctgcgcgg cagcccgtcg cgggccctca aggggaagcc caggccagga tggccccggg      540

tcgcgcggtg gccgggctcc tgttgctggc ggccgccggc ctcggaggag tggcggaggg      600

gccagggcta gccttcagcg aggatgtgct gagcgtgttc ggcgcgaatc tgagcctgtc      660

ggcggcgcag ctccagcact tgctggagca gatgggagcc gcctcccgcg tgggcgtccc      720

ggagcctggc cagctgcact tcaaccagtg tttaactgct gaagagatct tttcccttca      780

tggcttttca aatgctaccc aaataaccag ctccaaattc tctgtcatct gtccagcagt      840

cttacagcaa ttgaactttc acccatgtga ggatcggccc aagcacaaaa caagaccaag      900

tcattcagaa gtttggggat atggattcct gtcagtgacg attattaatc tggcatctct      960

cctcggattg attttgactc cactgataaa gaaatcttat ttcccaaaga ttttgacctt     1020

ttttgtgggg ctggctattg ggactctttt ttcaaatgca attttccaac ttattccaga     1080

ggcatttgga tttgatccca aagtcgacag ttatgttgag aaggcagttg ctgtgtttgg     1140

tggattttac ctacttttct tttttgaaag aatgctaaag atgttattaa agacatatgg     1200

tcagaatggt catacccact ttggaaatga taactttggt cctcaagaaa aaactcatca     1260

acctaaagca ttacctgcca tcaatggtgt gacatgctat gcaaatcctg ctgtcacaga     1320

agctaatgga catatccatt ttgataatgt cagtgtggta tctctacagg atggaaaaaa     1380

agagccaagt tcatgtacct gtttgaaggg gcccaaactg tcagaaatag ggacgattgc     1440

ctggatgata acgctctgcg atgccctcca caatttcatc gatggcctgg cgattggggc     1500

ttcctgcacc ttgtctctcc ttcagggact cagtacttcc atagcaatcc tatgtgagga     1560

gtttccccac gagttaggag actttgtgat cctactcaat gcagggatga gcactcgaca     1620

agccttgcta ttcaacttcc tttctgcatg ttcctgctat gttgggctag cttttggcat     1680

tttggtgggc aacaatttcg ctccaaatat tatatttgca cttgctggag gcatgttcct     1740

ctatatttct ctggcagata tgtttccaga gatgaatgat atgctgagag aaaaggtaac     1800

tggaagaaaa accgatttca ccttcttcat gattcagaat gctggaatgt taactggatt     1860

cacagccatt ctactcatta ccttgtatgc aggagaaatc gaattggagt aatagaaaat     1920

ggaagatggt gttgttaata aaggcattta atagataaaa acatctccaa aaaggatttt     1980

gaagctgatc ctatttagtt aaaaagataa ttttgctttc aactgtaggt ccagaaaact     2040

aattattggc atcagtctgt gaaatagtcc attatttgtt gttaaaaatg cttcaaaagg     2100

ttttcagtgt cagtctgaga tgcctggtat ataggagcct ttgggaaata cctatttttc     2160

agtattccat gcatattaga tatcaccatg aagcaagaga catgcattct ataatcatgt     2220

agacactcag actcagggga aaatacaagt tatatcctga aagcctttaa aactctatgg     2280

taggatcaaa gattcaaatg gtttcagaga ggttttattt caattaattt gttctagtgc     2340

tttcaagagc aagtacatca aaatgtagaa ggtaaaatgt atgcaacact aatataaatt     2400

attccaagtc tttaaggagc caaagaaaaa aaagatttct cacagctttt tgttctgttt     2460

tgtatttcaa ttaggaactt gcagtattat tttgaaaacc attctaaaat aataggagtt     2520

aggaaataaa taaagttttg ctagccctgc taagttcagg cttagaggct tatcgctaag     2580

tataaacttc accagattcc acgaaaagct ggatagcttt ttttctgact tatgttgtgg     2640

ttgcacccct cacaaatggc agaacagtat gtaaagctgg taacacctcg gtttcagtgc     2700

accatgtgtt tgctttgtga aggtgaagaa tatgttggtt tagagaaaga aattggatgt     2760

aattttatgc aatttacttt taaagacaaa cataactatt tagcagagaa tattttaata     2820

aatgcaaaac aacagctgga ctgctgtaca tcaaggacag attaactgga aaacatatgt     2880

tccttatgtg tgatcgagag ccattcagaa aagacttcct ttgtgttcag cctatacttt     2940

tccatatggt ataccttgaa aaaaattagc acaccatggt tatttttcta ccttttataa     3000

aagacagagc ctgtttactc atttagaaga tagagaaaat tggtctaaaa ttgaacatcc     3060

tagattcaca ctcccaagtc acttaaggtg atttgatggt gaggaaaatg attgacaaag     3120

cccaacaatg atctcaggaa ttacattttc caacagacca aaaaatgttt tcatgtagca     3180

gcaatgcaga tttggtgaat atttaatata tattttagta tgtatttcac tttatgactg     3240

acaattaaaa aatattgttt ggccaaatag taaacaccct tttgaaacca tgaaaaaaaa     3300

aaaaaaaaa                                                             3309


<210>  10
<211>  460
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ala Pro Gly Arg Ala Val Ala Gly Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Gly Leu Gly Gly Val Ala Glu Gly Pro Gly Leu Ala Phe Ser Glu Asp 
            20                  25                  30          


Val Leu Ser Val Phe Gly Ala Asn Leu Ser Leu Ser Ala Ala Gln Leu 
        35                  40                  45              


Gln His Leu Leu Glu Gln Met Gly Ala Ala Ser Arg Val Gly Val Pro 
    50                  55                  60                  


Glu Pro Gly Gln Leu His Phe Asn Gln Cys Leu Thr Ala Glu Glu Ile 
65                  70                  75                  80  


Phe Ser Leu His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys 
                85                  90                  95      


Phe Ser Val Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro 
            100                 105                 110         


Cys Glu Asp Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val 
        115                 120                 125             


Trp Gly Tyr Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu 
    130                 135                 140                 


Leu Gly Leu Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys 
145                 150                 155                 160 


Ile Leu Thr Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn 
                165                 170                 175     


Ala Ile Phe Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val 
            180                 185                 190         


Asp Ser Tyr Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu 
        195                 200                 205             


Leu Phe Phe Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly 
    210                 215                 220                 


Gln Asn Gly His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu 
225                 230                 235                 240 


Lys Thr His Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys 
                245                 250                 255     


Tyr Ala Asn Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp 
            260                 265                 270         


Asn Val Ser Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser 
        275                 280                 285             


Cys Thr Cys Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala 
    290                 295                 300                 


Trp Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr 
                325                 330                 335     


Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe 
            340                 345                 350         


Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe 
        355                 360                 365             


Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile 
    370                 375                 380                 


Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly 
385                 390                 395                 400 


Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn 
                405                 410                 415     


Asp Met Leu Arg Glu Lys Val Thr Gly Arg Lys Thr Asp Phe Thr Phe 
            420                 425                 430         


Phe Met Ile Gln Asn Ala Gly Met Leu Thr Gly Phe Thr Ala Ile Leu 
        435                 440                 445             


Leu Ile Thr Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
    450                 455                 460 


<210>  11
<211>  5816
<212>  DNA
<213>  homo sapiens

<400>  11
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tacatcaggc gacagttaga ggaggagcag agacagttag agatcttgca gcagcagcta     1740

ctgcatgaac aagctctact tctggaatat aagcgcaaac aattggaaga acagagacaa     1800

gcagaaagac tgcagaggca gctaaagcaa gaaagagact acttagtttc ccttcagcat     1860

cagcggcagg agcagaggcc tgtggagaag aagccactgt accattacaa agaaggaatg     1920

agtcctagtg agaagccagc atgggccaag gaggtagaag aacggtcaag gctcaaccgg     1980

caaagttccc ctgccatgcc tcacaaggtt gccaacagga tatctgaccc caacctgccc     2040

ccaaggtcgg agtccttcag cattagtgga gttcagcctg ctcgaacacc ccccatgctc     2100

agaccagtcg atccccagat cccacatctg gtagctgtaa aatcccaggg acctgccttg     2160

accgcctccc agtcagtgca cgagcagccc acaaagggcc tctctgggtt tcaggaggct     2220

ctgaacgtga cctcccaccg cgtggagatg ccacgccaga actcagatcc cacctcggaa     2280

aatcctcctc tccccactcg cattgaaaag tttgaccgaa gctcttggtt acgacaggaa     2340

gaagacattc caccaaaggt gcctcaaaga acaacttcta tatccccagc attagccaga     2400

aagaattctc ctgggaatgg tagtgctctg ggacccagac taggatctca acccatcaga     2460

gcaagcaacc ctgatctccg gagaactgag cccatcttgg agagcccctt gcagaggacc     2520

agcagtggca gttcctccag ctccagcacc cctagctccc agcccagctc ccaaggaggc     2580

tcccagcctg gatcacaagc aggatccagt gaacgcacca gagttcgagc caacagtaag     2640

tcagaaggat cacctgtgct cccccatgag cctgccaagg tgaaaccaga agaatccagg     2700

gacattaccc ggcccagtcg accagctagc tacaaaaaag ctatagatga ggatctgacg     2760

gcattagcca aagaactaag agaactccgg attgaagaaa caaaccgccc aatgaagaag     2820

gtgactgatt actcctcctc cagtgaggag tcagaaagta gcgaggaaga ggaggaagat     2880

ggagagagcg agacccatga tgggacagtg gctgtcagcg acatacccag actgatacca     2940

acaggagctc caggcagcaa cgagcagtac aatgtgggaa tggtggggac gcatgggctg     3000

gagacctctc atgcggacag tttcagcggc agtatttcaa gagaaggaac cttgatgatt     3060

agagagacgt ctggagagaa gaagcgatct ggccacagtg acagcaatgg ctttgctggc     3120

cacatcaacc tccctgacct ggtgcagcag agccattctc cagctggaac cccgactgag     3180

ggactggggc gcgtctcaac ccattcccag gagatggact ctgggactga atatggcatg     3240

gggagcagca ccaaagcctc cttcaccccc tttgtggacc ccagagtata ccagacgtct     3300

cccactgatg aagatgaaga ggatgaggaa tcatcagccg cagctctgtt tactagcgaa     3360

cttcttaggc aagaacaggc caaactcaat gaagcaagaa agatttcggt ggtaaatgta     3420

aacccaacca acattcggcc tcatagcgac acaccagaaa tcagaaaata caagaaacga     3480

ttcaactcag aaatactttg tgcagctctg tggggtgtaa accttctggt ggggactgaa     3540

aatggcctga tgcttttgga ccgaagtggg caaggcaaag tctataatct gatcaaccgg     3600

aggcgatttc agcagatgga tgtgctagag ggactgaatg tccttgtgac aatttcagga     3660

aagaagaata agctacgagt ttactatctt tcatggttaa gaaacagaat actacataat     3720

gacccagaag tagaaaagaa acaaggctgg atcactgttg gggacttgga aggctgtata     3780

cattataaag ttgttaaata tgaaaggatc aaatttttgg tgattgcctt aaagaatgct     3840

gtggaaatat atgcttgggc tcctaaaccg tatcataaat tcatggcatt taagtctttt     3900

gcagatctcc agcacaagcc tctgctagtt gatctcacgg tagaagaagg tcaaagatta     3960

aaggttattt ttggttcaca cactggtttc catgtaattg atgttgattc aggaaactct     4020

tatgatatct acataccatc tcatattcag ggcaatatca ctcctcatgc tattgtcatc     4080

ttgcctaaaa cagatggaat ggaaatgctt gtttgctatg aggatgaggg ggtgtatgta     4140

aacacctatg gccggataac taaggatgtg gtgctccaat ggggagaaat gcccacgtct     4200

gtggcctaca ttcattccaa tcagataatg ggctggggcg agaaagctat tgagatccgg     4260

tcagtggaaa caggacattt ggatggagta tttatgcata agcgagctca aaggttaaag     4320

tttctatgtg aaagaaatga taaggtattt tttgcatccg tgcgatctgg aggaagtagc     4380

caagtgtttt tcatgaccct caacagaaat tccatgatga actggtaaca gaagagcact     4440

tggcacttat cttcatggcg ttatttctaa tttaaaagaa cataactcat gtggacttat     4500

gccagtctag aggcagaatc agaaggcttg gttgaacata tcgctttccc tttttcctct     4560

ccctccgccc ctcccagtac agtccatctt tcaatgttgc agcctggttg agaaggagag     4620

aaaaaggtgg caggaatttc caggagatcc ccaagaatgc tgccttgtct gtggacaaag     4680

atggaccatg tgcccttcgg aattagggat agaaacaaat attgtgtgct cttaacgatt     4740

aagctgtgtt atggtgggtt ttcaggtttt tacctttttt ctttacccct ttactctgca     4800

agaatgggga aagaatgcat actgcgaaaa tgagtctttt aaattctgtc tgcctactag     4860

ttttaagtat atggtatgtt gtaaaatttc caatgatgag agacagcaca ataaatgtac     4920

cttatctcct taggctgaag gccataacta catagtggag taatttaaga actctcttgc     4980

cttcaccaac ccaaaaggtt gctttttgat agcaactggc taatgaattt ttaaaaagag     5040

aagaaaaata ctagttttcc cctcttttgg gaaatagatt ttaaatggct aaactactag     5100

ccttaaaact actagtctaa taaaatcaac taccactttt gtgaatctga caggccacat     5160

ttttatatgg ccctttacag aatggagtgt gttgaacagg atactaacgc cattgagttg     5220

agctggccta gcgatggagg gacactctaa cacaactttc cctcagctat tatgcaacag     5280

atcagggaaa aagatgggat gacagatggg gtcagacaga aagagcttct gggaaacaag     5340

cttacatagt cttttttaaa atgcacaaag cctcccagct aagaggtcac ttggtttggg     5400

cttcattagg actgagactt tgttgagttc tttctgggac ttggagagtg gatgatattc     5460

aggctctgaa cattcccagc gctctcccga gggtgccact ttctcaagat gaaaactgtg     5520

actgaaaaaa ttaataataa atgtttctga gctgcctgtg ttctccctgt gtgggtgaga     5580

gaagggacta gactcctaag cctgcctcag atacaagagg catcattggc tccaatttta     5640

gagaacttga aagcaaggct ttggacaaaa ttttgagacc ctaatcactt taccttcctc     5700

caaattaccc aacatacggt aaacaacatt tgtgcagaag tatgtatgta tttagttcag     5760

gttgacttgt gtccttataa actcttactc aaatgatttg aactttaaaa aaaaaa         5816


<210>  12
<211>  1360
<212>  PRT
<213>  homo sapiens

<400>  12

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Ile Arg 
        435                 440                 445             


Arg Gln Leu Glu Glu Glu Gln Arg Gln Leu Glu Ile Leu Gln Gln Gln 
    450                 455                 460                 


Leu Leu His Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu 
465                 470                 475                 480 


Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Lys Gln Glu 
                485                 490                 495     


Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu Gln Arg Pro 
            500                 505                 510         


Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met Ser Pro Ser 
        515                 520                 525             


Glu Lys Pro Ala Trp Ala Lys Glu Val Glu Glu Arg Ser Arg Leu Asn 
    530                 535                 540                 


Arg Gln Ser Ser Pro Ala Met Pro His Lys Val Ala Asn Arg Ile Ser 
545                 550                 555                 560 


Asp Pro Asn Leu Pro Pro Arg Ser Glu Ser Phe Ser Ile Ser Gly Val 
                565                 570                 575     


Gln Pro Ala Arg Thr Pro Pro Met Leu Arg Pro Val Asp Pro Gln Ile 
            580                 585                 590         


Pro His Leu Val Ala Val Lys Ser Gln Gly Pro Ala Leu Thr Ala Ser 
        595                 600                 605             


Gln Ser Val His Glu Gln Pro Thr Lys Gly Leu Ser Gly Phe Gln Glu 
    610                 615                 620                 


Ala Leu Asn Val Thr Ser His Arg Val Glu Met Pro Arg Gln Asn Ser 
625                 630                 635                 640 


Asp Pro Thr Ser Glu Asn Pro Pro Leu Pro Thr Arg Ile Glu Lys Phe 
                645                 650                 655     


Asp Arg Ser Ser Trp Leu Arg Gln Glu Glu Asp Ile Pro Pro Lys Val 
            660                 665                 670         


Pro Gln Arg Thr Thr Ser Ile Ser Pro Ala Leu Ala Arg Lys Asn Ser 
        675                 680                 685             


Pro Gly Asn Gly Ser Ala Leu Gly Pro Arg Leu Gly Ser Gln Pro Ile 
    690                 695                 700                 


Arg Ala Ser Asn Pro Asp Leu Arg Arg Thr Glu Pro Ile Leu Glu Ser 
705                 710                 715                 720 


Pro Leu Gln Arg Thr Ser Ser Gly Ser Ser Ser Ser Ser Ser Thr Pro 
                725                 730                 735     


Ser Ser Gln Pro Ser Ser Gln Gly Gly Ser Gln Pro Gly Ser Gln Ala 
            740                 745                 750         


Gly Ser Ser Glu Arg Thr Arg Val Arg Ala Asn Ser Lys Ser Glu Gly 
        755                 760                 765             


Ser Pro Val Leu Pro His Glu Pro Ala Lys Val Lys Pro Glu Glu Ser 
    770                 775                 780                 


Arg Asp Ile Thr Arg Pro Ser Arg Pro Ala Ser Tyr Lys Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Glu Leu Arg Ile 
                805                 810                 815     


Glu Glu Thr Asn Arg Pro Met Lys Lys Val Thr Asp Tyr Ser Ser Ser 
            820                 825                 830         


Ser Glu Glu Ser Glu Ser Ser Glu Glu Glu Glu Glu Asp Gly Glu Ser 
        835                 840                 845             


Glu Thr His Asp Gly Thr Val Ala Val Ser Asp Ile Pro Arg Leu Ile 
    850                 855                 860                 


Pro Thr Gly Ala Pro Gly Ser Asn Glu Gln Tyr Asn Val Gly Met Val 
865                 870                 875                 880 


Gly Thr His Gly Leu Glu Thr Ser His Ala Asp Ser Phe Ser Gly Ser 
                885                 890                 895     


Ile Ser Arg Glu Gly Thr Leu Met Ile Arg Glu Thr Ser Gly Glu Lys 
            900                 905                 910         


Lys Arg Ser Gly His Ser Asp Ser Asn Gly Phe Ala Gly His Ile Asn 
        915                 920                 925             


Leu Pro Asp Leu Val Gln Gln Ser His Ser Pro Ala Gly Thr Pro Thr 
    930                 935                 940                 


Glu Gly Leu Gly Arg Val Ser Thr His Ser Gln Glu Met Asp Ser Gly 
945                 950                 955                 960 


Thr Glu Tyr Gly Met Gly Ser Ser Thr Lys Ala Ser Phe Thr Pro Phe 
                965                 970                 975     


Val Asp Pro Arg Val Tyr Gln Thr Ser Pro Thr Asp Glu Asp Glu Glu 
            980                 985                 990         


Asp Glu Glu Ser Ser Ala Ala Ala  Leu Phe Thr Ser Glu  Leu Leu Arg 
        995                 1000                 1005             


Gln Glu  Gln Ala Lys Leu Asn  Glu Ala Arg Lys Ile  Ser Val Val 
    1010                 1015                 1020             


Asn Val  Asn Pro Thr Asn Ile  Arg Pro His Ser Asp  Thr Pro Glu 
    1025                 1030                 1035             


Ile Arg  Lys Tyr Lys Lys Arg  Phe Asn Ser Glu Ile  Leu Cys Ala 
    1040                 1045                 1050             


Ala Leu  Trp Gly Val Asn Leu  Leu Val Gly Thr Glu  Asn Gly Leu 
    1055                 1060                 1065             


Met Leu  Leu Asp Arg Ser Gly  Gln Gly Lys Val Tyr  Asn Leu Ile 
    1070                 1075                 1080             


Asn Arg  Arg Arg Phe Gln Gln  Met Asp Val Leu Glu  Gly Leu Asn 
    1085                 1090                 1095             


Val Leu  Val Thr Ile Ser Gly  Lys Lys Asn Lys Leu  Arg Val Tyr 
    1100                 1105                 1110             


Tyr Leu  Ser Trp Leu Arg Asn  Arg Ile Leu His Asn  Asp Pro Glu 
    1115                 1120                 1125             


Val Glu  Lys Lys Gln Gly Trp  Ile Thr Val Gly Asp  Leu Glu Gly 
    1130                 1135                 1140             


Cys Ile  His Tyr Lys Val Val  Lys Tyr Glu Arg Ile  Lys Phe Leu 
    1145                 1150                 1155             


Val Ile  Ala Leu Lys Asn Ala  Val Glu Ile Tyr Ala  Trp Ala Pro 
    1160                 1165                 1170             


Lys Pro  Tyr His Lys Phe Met  Ala Phe Lys Ser Phe  Ala Asp Leu 
    1175                 1180                 1185             


Gln His  Lys Pro Leu Leu Val  Asp Leu Thr Val Glu  Glu Gly Gln 
    1190                 1195                 1200             


Arg Leu  Lys Val Ile Phe Gly  Ser His Thr Gly Phe  His Val Ile 
    1205                 1210                 1215             


Asp Val  Asp Ser Gly Asn Ser  Tyr Asp Ile Tyr Ile  Pro Ser His 
    1220                 1225                 1230             


Ile Gln  Gly Asn Ile Thr Pro  His Ala Ile Val Ile  Leu Pro Lys 
    1235                 1240                 1245             


Thr Asp  Gly Met Glu Met Leu  Val Cys Tyr Glu Asp  Glu Gly Val 
    1250                 1255                 1260             


Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys Asp Val  Val Leu Gln 
    1265                 1270                 1275             


Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr Ile His  Ser Asn Gln 
    1280                 1285                 1290             


Ile Met  Gly Trp Gly Glu Lys  Ala Ile Glu Ile Arg  Ser Val Glu 
    1295                 1300                 1305             


Thr Gly  His Leu Asp Gly Val  Phe Met His Lys Arg  Ala Gln Arg 
    1310                 1315                 1320             


Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys Val Phe  Phe Ala Ser 
    1325                 1330                 1335             


Val Arg  Ser Gly Gly Ser Ser  Gln Val Phe Phe Met  Thr Leu Asn 
    1340                 1345                 1350             


Arg Asn  Ser Met Met Asn Trp  
    1355                 1360 


<210>  13
<211>  2133
<212>  DNA
<213>  homo sapiens

<400>  13
cgggccaatc gttagtcaga gtgggcggag ccgcccgcgg gcacctgcgc gttaagagtg       60

ggccgcgtcg ctgaggggta gcgatgcggg ctccggggat gaggtcgcgg ccggcgggtc      120

ccgcgctgtt gctgctgctg ctcttcctcg gagcggccga gtcggtgcgt cgggcccagc      180

ctccgcgccg ctacacccca gactggccga gcctggattc tcggccgctg ccggcctggt      240

tcgacgaagc caagttcggg gtgttcatcc actggggcgt gttctcggtg cccgcctggg      300

gcagcgagtg gttctggtgg cactggcagg gcgaggggcg gccgcagtac cagcgcttca      360

tgcgcgacaa ctacccgccc ggcttcagct acgccgactt cggaccgcag ttcactgcgc      420

gcttcttcca cccggaggag tgggccgacc tcttccaggc cgcgggcgcc aagtatgtag      480

ttttgacgac aaagcatcac gaaggcttca caaactggcc gagtcctgtg tcttggaact      540

ggaactccaa agacgtgggg cctcatcggg atttggttgg tgaattggga acagctctcc      600

ggaagaggaa catccgctat ggactatacc actcactctt agagtggttc catccactct      660

atctacttga taagaaaaat ggcttcaaaa cacagcattt tgtcagtgca aaaacaatgc      720

cagagctgta cgaccttgtt aacagctata aacctgatct gatctggtct gatggggagt      780

gggaatgtcc tgatacttac tggaactcca caaattttct ttcatggctc tacaatgaca      840

gccctgtcaa ggatgaggtg gtagtaaatg accgatgggg tcagaactgt tcctgtcacc      900

atggaggata ctataactgt gaagataaat tcaagccaca gagcttgcca gatcacaagt      960

gggagatgtg caccagcatt gacaagtttt cctggggcta tcgtcgtgac atggcattgt     1020

ctgatgttac agaagaatct gaaatcattt cggaactggt tcagacagta agtttgggag     1080

gcaactatct tctgaacatt ggaccaacta aagatggact gattgttccc atcttccaag     1140

aaaggcttct tgctgttggg aaatggctga gcatcaatgg ggaggctatc tatgcctcca     1200

aaccatggcg ggtgcaatgg gaaaagaaca caacatctgt atggtatacc tcaaagggat     1260

cggctgttta tgccattttt ctgcactggc cagaaaatgg agtcttaaac cttgaatccc     1320

ccataactac ctcaactaca aagataacaa tgctgggaat tcaaggagat ctgaagtggt     1380

ccacagatcc agataaaggt ctcttcatct ctctacccca gttgccaccc tctgctgtcc     1440

ccgcagagtt tgcttggact ataaagctga caggagtgaa gtaatcattt gagtgcaaga     1500

agaaagaggc gctgctcact gttttcctgc ttcagttttt ctcttatagt accatcacta     1560

taatcaacga acttctcttc tccacccaga gatggctttt ccaacacatt ttaattaaag     1620

gaactgagta cattaccctg atgtctaaat ggaccaaaga tctgagatcc attgtgatta     1680

tatctgtatc aggtcagcag aagaaggaac tgagcagttg aactctgagt tcatcaattg     1740

taatatttgg aaattatcta caatggaatc ttccctctgt tctctgataa cctacttgct     1800

tactcaatgc ctttaagcca agtcaccctg ttgcctatgg gaggaggtgg aaggatttgg     1860

caagctcaac cacatgctat ttagttagca tcagttgtca ccaacagtct ttctgcaaag     1920

ggcaggagag ctttggggga aaggaaaagg cttaccaggc tgctatggtc aactcttcag     1980

aaattttcag agcaatctaa aagcgccaaa attcgctatg tttacagtga tactattaag     2040

aaaatgaatg tgattctgct ctgtcttttt aagtatgatc aaataaaaaa tttgtacatc     2100

acaatcattt ctaccaaaaa aaaaaaaaaa aaa                                  2133


<210>  14
<211>  466
<212>  PRT
<213>  homo sapiens

<400>  14

Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     


<210>  15
<211>  12957
<212>  DNA
<213>  homo sapiens

<400>  15
gaaaacaact cacgaggcaa aaaagtacat ctcgtggatg gagcagggcg aagtggttac       60

aagtacagac tctggagcca gactgcctgg gtttgaattg tgcggtttca gatttctgcc      120

tggcagatta accaacggca agagaggctg atctgtctac attctgagta ctgcccttgg      180

caagacacct agaacagacc ctggacccaa gtctaccgta ctaccatacc cctactccag      240

cccaccccag acagtattct ggggttcacc tgaggtcagc agtgtgaaga tgaccagtgc      300

ctttttagca tgacgacttt ggaccatgtg attgccaccc accagtcaga atgggtctcc      360

ttcaatgaag agccaccctt tcctgcccac tcgcaggggg gcacggaaga gcacctccca      420

ggactgtcat cttccccaga ccagtccgag agctcctccg gggagaacca tgtggtggat      480

ggaggctctc aagaccattc ccactcggag caggatgact cctctgaaaa gatgggcctc      540

atctctgaag cagcttcccc acctgggagc cctgagcagc ccccacctga cctggcctcg      600

gccatcagca actgggttca gtttgaagat gacacaccct gggccagcac atctccacct      660

catcaggaaa cagctgagac agccctacca ttgaccatgc cctgctggac atgcccttcc      720

tttgactccc tggggagatg ccctctgact tctgagagca gctggaccac ccattctgaa      780

gacaccagca gtcctagctt tggatgttcg tatacagatc tgcagctcat caatgctgag      840

gagcagacga gtggccaggc ttctggggct gactcaactg acaattcctc ctcgcttcaa      900

gaagatgaag aagtagagat ggaggccatc agctggcagg ccagcagtcc agccatgaat      960

gggcaccctg cccctccagt gacctctgct cgttttccca gctgggtcac ctttgatgac     1020

aatgaagtca gctgcccttt accaccagtc acctctcctc tgaagccaaa tacaccacca     1080

agtgcatctg tgatcccaga tgtaccttat aattcaatgg gatcatttaa gaagagggac     1140

cgtcccaaga gcactttgat gaacttctcc aaagttcaga agctggatat ttcctcttta     1200

aaccgcacgc cttctgtaac tgaggcttca ccttggaggg caaccaaccc tttcctgaat     1260

gagactctgc aggatgtaca gccctcccct atcaaccctt tcagtgcttt ctttgaggag     1320

caggagaggc gctcccaaaa cagttccatt tccagtacca cgggcaaaag ccaaagagat     1380

tccctcattg tcatctacca ggatgccatc agttttgatg attcaagcaa aacccagtca     1440

cactctgatg ctgttgaaaa actcaaacaa ctccaaattg atgaccctga tcactttggc     1500

agtgcaactc tacctgatga tgacccagta gcctggattg aactagatgc tcacccgcct     1560

ggatcagcac ggtcccagcc tcgtgacggg tggccaatga tgttgaggat ccctgagaag     1620

aaaaacatca tgtcctccag gcactgggga ccgatcttcg tcaaactgac agacactggt     1680

tacctgcagc tgtattatga gcagggccta gaaaaaccat tccgtgagtt caagctggag     1740

atctgtcatg agatttcaga accccggctt caaaactatg atgagaatgg cagaatccac     1800

agcttgcgga tagaccgtgt cacctataaa gagaagaaga aataccagcc caaacctgct     1860

gtggcccaca cagcagagag ggaacaggtg attaagctgg gcaccaccaa ttacgatgac     1920

ttcctgagtt tcatccatgc agttcaggac cgtctcatgg atctgccagt gttgtcaatg     1980

gacttgagca cagttggcct caactacctt gaagaggaga ttacagtgga tgtcagagat     2040

gaattctctg gcattgtgag caaaggagac aaccagattc tccagcacca tgtcttgaca     2100

cggatccaca tcctgagttt cctgtctggg ctcgcagagt gccgcctggg cctcaatgac     2160

atcctcgtca aagggaatga aatagttttg aggcaggaca tcatgcccac caccaccaca     2220

aagtggatca agctccatga gtgccgtttc catgggtgtg tggatgagga tgttttccac     2280

aactcacggg tcattctgtt caaccctttg gatgcgtgcc ggtttgagct aatgcggttc     2340

aggacagtgt ttgctgagaa gaccttgcct ttcacactca ggacggccac aagtgtcaat     2400

ggggcagagg tggaggtgca gagctggctg aggatgtcaa ctggcttctc cgccaatcgt     2460

gaccccctca ctcaggttcc ctgtgagaat gtgatgatcc gttaccctgt gcccagtgag     2520

tgggtgaaaa acttccgcag ggaaagtgtc ctgggggaaa agtctttgaa agccaaagtg     2580

aaccgggggg caagttttgg ctccactagt gtttctggct ctgagcctgt catgagagta     2640

actctgggaa ctgccaagta cgagcatgcc ttcaactcca ttgtgtggag gataaaccga     2700

ctgccggaca aaaactcagc ttccggtcac ccacactgtt tcttttgcca ccttgaactc     2760

ggctctgacc gggaagtgcc ttccagattt gccaatcacg tgaatgtcga gttcagcatg     2820

cccacaactt ctgcctccaa agccagcgtg agatctatct ctgtagaaga caagactgac     2880

gtcaggaagt gggtcaatta ttctgcacac tacagctacc aggtagcctt gggaagcatc     2940

tggctaatgc ttccaactcc atttgttcac cccactaccc tccccctctt attcctttta     3000

gccatgctta ctatgttcgc ctggtaacct cttactgcct tagaggaagt tcaccataca     3060

tagctgtggg tgcgtctgct ctgatttaaa tgcataatct ggctagtgga tgagagaaag     3120

gttggaaaaa aataaagagg ctcatcaaag aggagaatat aatgtctttc tgtcattatg     3180

agcaatgaca acaaaaagaa taatgggggc caggcacagt ggctcacacc tgtaatccca     3240

gcactttggg aggtggaggt gggctgatta cttgagttca ggagttcaag accagcctgg     3300

ccaacatggc gaaaccccat ctctataaaa agtacaaaat tagccgggca tggtggcctg     3360

tgcatgtagt ccagctactc aggagactga ggtgggagga tcacttgact ctgggaggtt     3420

gagctgcagt gagccatgat tgcaccactg tactccagcc tgagtgacag agcgagactg     3480

tgtctcaaaa aaagaaaaag agtaatgggg taaaggaatt gttattattc atttgcaata     3540

taatttatgt cacagagtag tgagcttgga aatggagggg agaaaatgct atcccaaagc     3600

atatgcttca gttagagttg atgaagtgga cctgaacaaa gttaggacac acatgacctg     3660

ggtactgggc tataacagga caaaactcaa aagccaagca aatgtttata atagtaacag     3720

ggtcagggct gtggaaggaa tcataaaagt tggagttttc tgacataaat agaaagtgat     3780

actttcctgg ggagttagaa attcaatagg agattaaatg ccaacgattg gaaaaggagt     3840

ttgttaaaga aggattttgc aaagtggttt tctatttata ataatatcct tggatttata     3900

tggtgattta ttgttcctct aaatgtttcc ttagctgtgt gggctaaaat atttaactac     3960

caaaaggaac aaacactcca tcttgtggct aggaaaaaaa tagcacctcc ctcaaacctg     4020

actgttgtgt gttgaatcat taccctgtag gtcaagcgtc ataaatatcc agagtggtgc     4080

tgagaggagc aacctgaacc ctgagctcaa agaattcctt gcctgagcta tcaaagattt     4140

cggttgagat gtattacttt caaagattaa tctgttaatt tcttgataat tacagtgaca     4200

gtattttgca gaagatattg cagaactgta aacattccag tatttatcag ttcggaggtt     4260

ttctaaagag agaaagtact ggaggtggcc gggtgctgtg gctcatggct gtaatcccag     4320

acctttggga ggccaaggca ggtggatcat ttgaggtcag gaattcaaga acagcctggc     4380

caatatggtg aaaccctgtc cctactaaaa attcaaaaat tagccaggcg cagtggtgcg     4440

tgcctgtaat cttagctact ctggaggatg aggcaggaga atcacttgag cccgggaagt     4500

ggaggttgcg gtgagctgtg agccaagatt gtgccagtgc actccggtct gagtaacaga     4560

atgagaccct gtctcaaaaa aagaaaaaaa caagtattga gggggtacaa acagtcaatt     4620

acaaagaaat tcattcattt gataaatctt tgtcgattgc ccactgtatt cctacattat     4680

tgcataaaat attgaacaag atcctgccca tgtcttgtgg agcccatggt atagtggagc     4740

cagacaggtg tgcaagatac ggtggaaata ttcacagaga gaagtaccta agtctactta     4800

ataagtcaaa aatagcttca cagaaggggt gatctttgac caaatgtaca aggcaaagaa     4860

taagaatttt cctggtggac catgagggaa agggaattac agaccagtta aagaacatgt     4920

gcaaagagag agacatgata tactcagggc cagtagctcc aatgtggcta acgcccaaaa     4980

tgttagcaaa attataagaa atttcaaagt acctatggag ttttggttta cttatttatt     5040

tgcatgcttt ttctcttctt tttgatcttt atctccaact tctattcttg gcaggtggaa     5100

attgagcaaa aaaagagttt gaagccggac tttgaaggag atgaaatgga aaatcccaag     5160

gagtgtggag tgcagtgaca aagccttgcg gcaaggaatc ctgatcccag agtcatgata     5220

gggtgtcttc ctgagtcatg atagggtgtc ttcctgagta gctgaagttg cagtcaatac     5280

ctgctgtggc cactgcatgt tgggaacagt ataccagatc ttcctgtttg cagttacttg     5340

tattttacca ggaaaccctg agaatggtgg cttttggaga ggctctttga ttctggtcat     5400

gcctaaagca cgaggttcac ctgactgttg gagcttactg tataattaag cctccttgtc     5460

ttgtctctgc ttatctcaca gcactggtat gtggtttgtt gtgactgtta cagtcaggaa     5520

aagaacctcc cacatcagtg ttagcacgat tgccttctga tgttcatctg tcactcgcat     5580

aactttctgg caaaggcagt cttgagaagt taattaagaa tccatctctt tcactctgtc     5640

tagaaaaggt tcagaaaagg tgcaaaacaa atttcctctt tgggtcttac tagacctttt     5700

tgaggtgtct ccattcttta actgttaagc tttcaagaca tttccctcct ggctctagat     5760

cgtttagatt ggaacacttt ttccatctct ctaaggtttc agtcacagga tttgctatcc     5820

tgagtcacaa tagacaatgg aaaaaggcac aataggagac tttttaattt tgtgaatgga     5880

cccacattct gcaaaatggg tgttgagggg aaggcaaaat taatcttagt tttcttcatt     5940

ttggagaaaa gagacattaa atataagatg atgttcagtt caagaggtag attcaatctc     6000

agtgaattcc caaattcaca ctgaaaaata cagtccactt ctgattcctg aaacaaatat     6060

acataatacc tgaggcattt gtaaggggca tttgggagtt ctttttatac ctcatgacca     6120

atagacagtt gcatgtccct ttaacccaac tttataggaa atttaagctg caaagataat     6180

ttttaaagct gttttaaaat taagcttgaa tgagctttcc cccaaaattc agagtttgat     6240

aatcacagta ttggattgga ttgaaaaggc atctctaggg tagagacgtg gaaaagccat     6300

atttttctaa tgttgggaac attatattct gattccaaga gtcagaacgc tcactccatc     6360

ttctttttct tcatctgttt ctgggacaat taatcttctt ttccttcatc cgttcctact     6420

cacctctgct tcttatttgt atcttagtgt tttctcccat gaagaataca agtcggggga     6480

cagaaagcac acttcattgg atttgtagat gatgcagaaa tgaaaaatat ctccagtttt     6540

tggctgatgg attcaagatt aatgtattca atgaacaatc attggagtct aaatgtgtat     6600

tgacactggg atatagaaat agttacagta ttttgaaata tctgaactaa gactgaaagt     6660

aaaatgatga ttgaataggc attaatgaga aaccctatat tctgggtttt taaaatgcaa     6720

ccctctaagt acagagtgga gtgtgtgttt gtggatgtgt gtgtttgtgt gtgtttatgt     6780

gtgtggtgtt gatgggaacg gtgttaggaa gacctggttt cacggtagtt tatagagaaa     6840

tatttcctta cagaaatgga ggttcaatgt tgaatcagaa atatatcatg gctattcaca     6900

aagctaatgt agtcagctgg tgttaataaa agccttacat gcttttatta accctccatc     6960

tagtccatat ctaaatggag ggttgagttc aattatgggt atcatatttt aagagagaca     7020

ttaataagtt gattgtgtcc atagggaggt gaccagggtt gtaaagggtc tgatgatgca     7080

agaacaaggg agtagcttcc ctgaaggaac agaaggtata gctggaaagg gagtgcagac     7140

aaggagggaa tgatacaata gctgcctaga aatttctatt gagctatgaa aaggaagagg     7200

aattagattt attctgtgta gcttcaaagg gcaaaaataa gaacaaagag gaactttaca     7260

ggtgacaaat gtttgcttca atataaggaa gaattgtcta ataagagttg ttctaaagag     7320

gaatagactc aagttagtaa gatttcctgt tcctgtgaat gcccaacagt taaaataacc     7380

acctatccca cgtgctgtga aagggaatct tacattggat ttggtctata tgtctaccaa     7440

gattccttct aaatataggt ttagtctcaa tagtaataag actctctaac ttcatttgtc     7500

tttttcttca taagtggttt ttcatgctct ttgaaataca gtggagttcc tttgaggttt     7560

ttgtcaagga atttcaacgc atatctcttc ccctgttgta ctgaaggctt ttgagattaa     7620

ttcctcatag aacatctaaa tggattggag agttggcaag ggaaatgaag ctcatcccag     7680

caccttcctt agtcactcac gcttagcact ctgtcaagat ctctgcctca tctgctagca     7740

taacatgtgg attgcttgtt ggagcttatt tccccgcccc ccatggtaaa ttctcatttc     7800

ctgtgtacat gcacctggac ttttttgttt tttttaccaa gagttgggaa aaatcccttc     7860

tatgctatct atattctgca aacaaattat tattattatt attattgaga cagagtatta     7920

ttattattat tattattatt attactgaga caaagtttcg ctcttgtcgc ccaggctgga     7980

gtgcaatggc gtgatctcgg ctcattgcaa cctctgcctc ccaaatctcc tgcctcagcc     8040

tcctgagtag ctgggattac aggcgcctgc caccatgcac cactaattta tgtattttta     8100

gtagagatgg ggtttcacca tgttggccag gctggtctcg aatgtctgac ctcaggtgat     8160

aagcctgcct cagtctccca aagctctggg attacaggcg tgagccacca tgctggaccc     8220

acaaattatt attaattttt aaaaacctaa catcttaatt tcatcaaatt tgttttccct     8280

ctactgtttt taggaaactg attatgggta gcatttaggg gtttggggat aataatacta     8340

tatattttta gacgtaatga gtgttttact aggtttaaat aacttctaaa gaaaatacaa     8400

gtgggcaaat tagctatgta ataacctaca tagaaaacag ttgggcaaat tacctgtgga     8460

tatgcagatt ctacttttgc aaccctggac ctggactttt tatttttttt ttttgtggtc     8520

acaaataatc tttgttatca ataatgtgaa aatattaaaa atgaattcat tttaccagta     8580

catagtatta ctcttagaac ataaattaga tatcacgtgg tatcaagagc tgtgctttct     8640

tttgagtcta gggcctgctt tttgacttta cagcaaaaag ataagaaatg tactcatgac     8700

atgtcagaca agacaatgtg aggcactttg tggggagacc attagatgat cccccttgcc     8760

tgctcttgca gacatagtac tagttattcc ttatcaaaag tttgcatttc attcatatta     8820

aatattatct ggacagtttc attttttcta tttggctctt cccttactgt gccttcctgc     8880

attattggca gggttcataa tccttgagaa cattgtttga tttaaaatat tttttatttg     8940

aaatgagact gatttctatt caaatccagt ggctgggagt aagagtttat ttccctagaa     9000

acttatgttt ctgataaatg ggatccatga aggcaaggac tatatataat tttttgtgtt     9060

tccaacacct agcacaaagc ttggaatata atagggttca gccaccttaa atgcttgcca     9120

ggagggcaaa cgtatactca tgaaataaag gaaaatgagt atgtattcaa taaatgtttg     9180

ctgaaagaat actgaccctg agactcgaag gctacttaac ccttacttat catcaaatac     9240

tcataataaa gccagcaagc atgcttttat ttcctgaagg acttaaataa ttttgctttc     9300

cttttactcc tgcctccaga gtcaagtaat aaaacctgtc agcatttagg cacttaatat     9360

gctgctgaat ttgaactaca atgtacctca ttcacattga aaaacatttt tgtgccccaa     9420

agcatagtag catagatgct gtccatagtc acggtgattg attgctttgt tcctgcaagt     9480

caaacagatc catgagcctg agccttgccc atttcaatgg tcagtaggaa aagaaagcat     9540

ttgatagagt gcacaaccag tcttcatgca gtaggtcttt gttcttccag cactaaccgc     9600

tgaccgttac tttgcattta ttttgtcacc acagtaagat ggaggtctga gatagtaagg     9660

tcaaaatttg tgagataaag tcatgatttc agaggtgata tatatttcac cataagttta     9720

gtggtgggaa aacagaatga gctgaagttt tttcttaaaa gccttgggaa tattaaattg     9780

gtttaagtag gaagcactac catccagcct gcttatagaa atgctcccag ttcgagtggt     9840

aactttaact cttctaaaaa tgaggattat atgttaattc cagcatatct agaccttagt     9900

cagggaggtc caatcttttg gcttccctgg gccacatagg aagaagaatt gtcttgggtc     9960

acacataaaa tacagtaaca acagctgatg agctttaaaa acatggccaa aaaatagcat    10020

tttctttttt gttttttttt tttttttttt ttttgagacg gagtctcagt ctgtcaccca    10080

ggctagagtg cagtggcacg acatcggctc actgcaacct ccgcctcccg ggttcaagtg    10140

attctcctgc ctcaacctcc cgagtagctg ggactacagg catgtgccac cacgcctgac    10200

taatttttgt atttttagta gagatgggat ttcattatgt tggccagctg gtcttgaact    10260

tctgagctca ggtgatccac ccgccttagc ctcccagagt gctaggataa caggcatgag    10320

ccgccgcgcc tggccaaaat agcataatgt tttaagaaag tttacgaatt tgtcttgggc    10380

cacattcaaa accatcatgg gccaagggtt ggacaagcta gccttaggtc atgtccagaa    10440

tgcaatttaa caggaatttc aagcaaaact aacaaaaaat taaatccaca aaaaaatatc    10500

atttggtaaa tgcactgtct cacacacttt actactaagt cccattcaaa ccatgacgac    10560

cctttacata aaattagggc attctcacca agtttctaaa gatgatttct aaacattacc    10620

aaggtctaag tgctaattcc ccacaaacca tttcttatct tgtttaaatg agactggctt    10680

tagatatcat gactcatatt tatgtgttta aggaattaaa cgtgaaggag atgtataagg    10740

caaccacaaa tgtagaaaac aaatgtatgt attagtaata ttctcccatg tattaactag    10800

aacaagaatg tgagattttt acatttcttc tagtgtgcct tagcaaatct gctggaaaga    10860

gtctagttgt tttgagaatt gaaaaaaaaa tgtgtctctc aatttgtcaa ttctaagcct    10920

gtaaaggcag aaactatcca cagtaatgag tttggtagtg cctggagaga ggcaaatgat    10980

cattggatgt aacaaaagct acaagagaat agactaaaaa aagaatttca atatgaaaaa    11040

gtaaaatcta gagagatgac aaatcagcat tgggtaccaa gcctcaaaat acttgaacta    11100

gaagccatct cttaaagtta aaagtaagaa gctccaggaa aaataaagat tgcatagtaa    11160

aaagggatag atggcaggat taattcaact caacaaatat ttatcaaatg tctactctgg    11220

tcaggtgctg tgttagcagc cagcttccct aaagggagga aaggctagac acgaggacat    11280

tgaggattgt ttatttaaag tcactcatag gcatgccata atggatttat taaggggaaa    11340

ttggggtttc tgtgaatctt tacaggacat agccatggag acaatcacta tgttaagtaa    11400

gttgctgttt tcccaattgg gcttcagttt cctgagacaa aaaagtgagg aagttggatt    11460

aattgtttct tcaagtcctt tccagctcta aagttgtggg ttattttaca aaatatccat    11520

tggtgccacc tttcagtgac tcttcctatg tttataagaa ccaagaaatt taaattttga    11580

agattggaaa aatcacctgg tccatctttt tccttttcac atctctctct tttttttttt    11640

tttttttatc atttccccag acaacagaaa cagacaacct tccaaatcct ctatattgca    11700

gttgccttcc acacacagat ttaaaaagag gatcaaagag ggtggtgaag atcaggtgga    11760

atgcttcttt ggaagttcca ctggcatcat ctatcagaac aatggtgtga gcatgaagag    11820

gcacagacag gtctccaaaa tagatgttag gatttgggtg ctacctgaca cagaagtagg    11880

tctaaccctc caagtactgg ggatgatagg ataatcaatg aggtatatat atatttgtca    11940

ttttgtataa aatattgtga aaattgaagg aggacactca gtaaacatcc tgggactatt    12000

tgtaagttat ggcaaaacca gatgagagaa aagggacagt cccctctgta tcctcgttgt    12060

ctcttagtaa catcaaattg tagttaaaaa aattttaaac tatgtacaag ctacaaaata    12120

gcatctcttt catggtatgt ttgagtgtgt aattttagtt tcttttctgg ttgtatttgt    12180

ggtagtcaga tgtgttggat tgattccaac tggacagagt aaggaattcc agcatcctct    12240

tcctgcttgc tcgtgttacc ccacagatca aaccctcaat tctagttggg gatgctgtct    12300

agccccacac catgactgaa gccttaagca ctgttgcgcc tccatgtgct ttggatcagc    12360

aaccccagtg gtattctacc agagcattgt gggaaagcag atgtatagtc aggtcccaac    12420

agcaaattgt tgggtgtgag agttctaaag tataggggtg agggaagaga aggatatgaa    12480

ctcctctgac cttaagccag cattcattta acttttatgt ctacttaaca agagaacctg    12540

gagaaaacta ccgtattcaa gagattaatc aaaatcagtg ttttagccag gcgatgacag    12600

agaagcacca ttcctcaccc tccattcttg taatgtctgt aataaatttc agtgcgtcag    12660

gatggatgaa cccaagatcc agtgaatgat tcagctgttc caagccttac attttccatc    12720

attcatcatc cattctcatt cagtgtaacc tcttgcacta ttgtggttaa ttttatgtaa    12780

aaccagttta tgtttttttt tttttaatat gtgcctatgt aataaagtct acacactggc    12840

tatctctgta gaggtgaggt tttgttttta gttgttctac tgattatatc cttttctgag    12900

ctatgaaaat gaattattaa taaaaaattt ttgaacaaaa taaaaaaaaa aaaaaaa       12957


<210>  16
<211>  905
<212>  PRT
<213>  homo sapiens

<400>  16

Met Thr Thr Leu Asp His Val Ile Ala Thr His Gln Ser Glu Trp Val 
1               5                   10                  15      


Ser Phe Asn Glu Glu Pro Pro Phe Pro Ala His Ser Gln Gly Gly Thr 
            20                  25                  30          


Glu Glu His Leu Pro Gly Leu Ser Ser Ser Pro Asp Gln Ser Glu Ser 
        35                  40                  45              


Ser Ser Gly Glu Asn His Val Val Asp Gly Gly Ser Gln Asp His Ser 
    50                  55                  60                  


His Ser Glu Gln Asp Asp Ser Ser Glu Lys Met Gly Leu Ile Ser Glu 
65                  70                  75                  80  


Ala Ala Ser Pro Pro Gly Ser Pro Glu Gln Pro Pro Pro Asp Leu Ala 
                85                  90                  95      


Ser Ala Ile Ser Asn Trp Val Gln Phe Glu Asp Asp Thr Pro Trp Ala 
            100                 105                 110         


Ser Thr Ser Pro Pro His Gln Glu Thr Ala Glu Thr Ala Leu Pro Leu 
        115                 120                 125             


Thr Met Pro Cys Trp Thr Cys Pro Ser Phe Asp Ser Leu Gly Arg Cys 
    130                 135                 140                 


Pro Leu Thr Ser Glu Ser Ser Trp Thr Thr His Ser Glu Asp Thr Ser 
145                 150                 155                 160 


Ser Pro Ser Phe Gly Cys Ser Tyr Thr Asp Leu Gln Leu Ile Asn Ala 
                165                 170                 175     


Glu Glu Gln Thr Ser Gly Gln Ala Ser Gly Ala Asp Ser Thr Asp Asn 
            180                 185                 190         


Ser Ser Ser Leu Gln Glu Asp Glu Glu Val Glu Met Glu Ala Ile Ser 
        195                 200                 205             


Trp Gln Ala Ser Ser Pro Ala Met Asn Gly His Pro Ala Pro Pro Val 
    210                 215                 220                 


Thr Ser Ala Arg Phe Pro Ser Trp Val Thr Phe Asp Asp Asn Glu Val 
225                 230                 235                 240 


Ser Cys Pro Leu Pro Pro Val Thr Ser Pro Leu Lys Pro Asn Thr Pro 
                245                 250                 255     


Pro Ser Ala Ser Val Ile Pro Asp Val Pro Tyr Asn Ser Met Gly Ser 
            260                 265                 270         


Phe Lys Lys Arg Asp Arg Pro Lys Ser Thr Leu Met Asn Phe Ser Lys 
        275                 280                 285             


Val Gln Lys Leu Asp Ile Ser Ser Leu Asn Arg Thr Pro Ser Val Thr 
    290                 295                 300                 


Glu Ala Ser Pro Trp Arg Ala Thr Asn Pro Phe Leu Asn Glu Thr Leu 
305                 310                 315                 320 


Gln Asp Val Gln Pro Ser Pro Ile Asn Pro Phe Ser Ala Phe Phe Glu 
                325                 330                 335     


Glu Gln Glu Arg Arg Ser Gln Asn Ser Ser Ile Ser Ser Thr Thr Gly 
            340                 345                 350         


Lys Ser Gln Arg Asp Ser Leu Ile Val Ile Tyr Gln Asp Ala Ile Ser 
        355                 360                 365             


Phe Asp Asp Ser Ser Lys Thr Gln Ser His Ser Asp Ala Val Glu Lys 
    370                 375                 380                 


Leu Lys Gln Leu Gln Ile Asp Asp Pro Asp His Phe Gly Ser Ala Thr 
385                 390                 395                 400 


Leu Pro Asp Asp Asp Pro Val Ala Trp Ile Glu Leu Asp Ala His Pro 
                405                 410                 415     


Pro Gly Ser Ala Arg Ser Gln Pro Arg Asp Gly Trp Pro Met Met Leu 
            420                 425                 430         


Arg Ile Pro Glu Lys Lys Asn Ile Met Ser Ser Arg His Trp Gly Pro 
        435                 440                 445             


Ile Phe Val Lys Leu Thr Asp Thr Gly Tyr Leu Gln Leu Tyr Tyr Glu 
    450                 455                 460                 


Gln Gly Leu Glu Lys Pro Phe Arg Glu Phe Lys Leu Glu Ile Cys His 
465                 470                 475                 480 


Glu Ile Ser Glu Pro Arg Leu Gln Asn Tyr Asp Glu Asn Gly Arg Ile 
                485                 490                 495     


His Ser Leu Arg Ile Asp Arg Val Thr Tyr Lys Glu Lys Lys Lys Tyr 
            500                 505                 510         


Gln Pro Lys Pro Ala Val Ala His Thr Ala Glu Arg Glu Gln Val Ile 
        515                 520                 525             


Lys Leu Gly Thr Thr Asn Tyr Asp Asp Phe Leu Ser Phe Ile His Ala 
    530                 535                 540                 


Val Gln Asp Arg Leu Met Asp Leu Pro Val Leu Ser Met Asp Leu Ser 
545                 550                 555                 560 


Thr Val Gly Leu Asn Tyr Leu Glu Glu Glu Ile Thr Val Asp Val Arg 
                565                 570                 575     


Asp Glu Phe Ser Gly Ile Val Ser Lys Gly Asp Asn Gln Ile Leu Gln 
            580                 585                 590         


His His Val Leu Thr Arg Ile His Ile Leu Ser Phe Leu Ser Gly Leu 
        595                 600                 605             


Ala Glu Cys Arg Leu Gly Leu Asn Asp Ile Leu Val Lys Gly Asn Glu 
    610                 615                 620                 


Ile Val Leu Arg Gln Asp Ile Met Pro Thr Thr Thr Thr Lys Trp Ile 
625                 630                 635                 640 


Lys Leu His Glu Cys Arg Phe His Gly Cys Val Asp Glu Asp Val Phe 
                645                 650                 655     


His Asn Ser Arg Val Ile Leu Phe Asn Pro Leu Asp Ala Cys Arg Phe 
            660                 665                 670         


Glu Leu Met Arg Phe Arg Thr Val Phe Ala Glu Lys Thr Leu Pro Phe 
        675                 680                 685             


Thr Leu Arg Thr Ala Thr Ser Val Asn Gly Ala Glu Val Glu Val Gln 
    690                 695                 700                 


Ser Trp Leu Arg Met Ser Thr Gly Phe Ser Ala Asn Arg Asp Pro Leu 
705                 710                 715                 720 


Thr Gln Val Pro Cys Glu Asn Val Met Ile Arg Tyr Pro Val Pro Ser 
                725                 730                 735     


Glu Trp Val Lys Asn Phe Arg Arg Glu Ser Val Leu Gly Glu Lys Ser 
            740                 745                 750         


Leu Lys Ala Lys Val Asn Arg Gly Ala Ser Phe Gly Ser Thr Ser Val 
        755                 760                 765             


Ser Gly Ser Glu Pro Val Met Arg Val Thr Leu Gly Thr Ala Lys Tyr 
    770                 775                 780                 


Glu His Ala Phe Asn Ser Ile Val Trp Arg Ile Asn Arg Leu Pro Asp 
785                 790                 795                 800 


Lys Asn Ser Ala Ser Gly His Pro His Cys Phe Phe Cys His Leu Glu 
                805                 810                 815     


Leu Gly Ser Asp Arg Glu Val Pro Ser Arg Phe Ala Asn His Val Asn 
            820                 825                 830         


Val Glu Phe Ser Met Pro Thr Thr Ser Ala Ser Lys Ala Ser Val Arg 
        835                 840                 845             


Ser Ile Ser Val Glu Asp Lys Thr Asp Val Arg Lys Trp Val Asn Tyr 
    850                 855                 860                 


Ser Ala His Tyr Ser Tyr Gln Val Ala Leu Gly Ser Ile Trp Leu Met 
865                 870                 875                 880 


Leu Pro Thr Pro Phe Val His Pro Thr Thr Leu Pro Leu Leu Phe Leu 
                885                 890                 895     


Leu Ala Met Leu Thr Met Phe Ala Trp 
            900                 905 


<210>  17
<211>  3070
<212>  DNA
<213>  homo sapiens

<400>  17
ggcgccgtct tgatactttc agaaagaatg cattccctgt aaaaaaaaaa aaaaaatact       60

gagagaggga gagagagaga gaagaagaga gagagacgga gggagagcga gacagagcga      120

gcaacgcaat ctgaccgagc aggtcgtacg ccgccgcctc ctcctcctct ctgctcttcg      180

ctacccaggt gacccgagga gggactccgc ctccgagcgg ctgaggaccc cggtgcagag      240

gagcctggct cgcagaattg cagagtcgtc gccccttttt acaacctggt cccgttttat      300

tctgccgtac ccagtttttg gatttttgtc ttccccttct tctctttgct aaacgacccc      360

tccaagataa tttttaaaaa accttctcct ttgctcacct ttgcttccca gccttcccat      420

ccccccaccg aaagcaaatc attcaacgac ccccgaccct ccgacggcag gagccccccg      480

acctcccagg cggaccgccc tccctccccg cgcgcgggtt ccgggcccgg cgagagggcg      540

cgagcacagc cgaggccatg gaggtgacgg cggaccagcc gcgctgggtg agccaccacc      600

accccgccgt gctcaacggg cagcacccgg acacgcacca cccgggcctc agccactcct      660

acatggacgc ggcgcagtac ccgctgccgg aggaggtgga tgtgcttttt aacatcgacg      720

gtcaaggcaa ccacgtcccg ccctactacg gaaactcggt cagggccacg gtgcagaggt      780

accctccgac ccaccacggg agccaggtgt gccgcccgcc tctgcttcat ggatccctac      840

cctggctgga cggcggcaaa gccctgggca gccaccacac cgcctccccc tggaatctca      900

gccccttctc caagacgtcc atccaccacg gctccccggg gcccctctcc gtctaccccc      960

cggcctcgtc ctcctccttg tcggggggcc acgccagccc gcacctcttc accttcccgc     1020

ccaccccgcc gaaggacgtc tccccggacc catcgctgtc caccccaggc tcggccggct     1080

cggcccggca ggacgagaaa gagtgcctca agtaccaggt gcccctgccc gacagcatga     1140

agctggagtc gtcccactcc cgtggcagca tgaccgccct gggtggagcc tcctcgtcga     1200

cccaccaccc catcaccacc tacccgccct acgtgcccga gtacagctcc ggactcttcc     1260

cccccagcag cctgctgggc ggctccccca ccggcttcgg atgcaagtcc aggcccaagg     1320

cccggtccag cacagaaggc agggagtgtg tgaactgtgg ggcaacctcg accccactgt     1380

ggcggcgaga tggcacggga cactacctgt gcaacgcctg cgggctctat cacaaaatga     1440

acggacagaa ccggcccctc attaagccca agcgaaggct gtctgcagcc aggagagcag     1500

ggacgtcctg tgcgaactgt cagaccacca caaccacact ctggaggagg aatgccaatg     1560

gggaccctgt ctgcaatgcc tgtgggctct actacaagct tcacaatatt aacagacccc     1620

tgactatgaa gaaggaaggc atccagacca gaaaccgaaa aatgtctagc aaatccaaaa     1680

agtgcaaaaa agtgcatgac tcactggagg acttccccaa gaacagctcg tttaacccgg     1740

ccgccctctc cagacacatg tcctccctga gccacatctc gcccttcagc cactccagcc     1800

acatgctgac cacgcccacg ccgatgcacc cgccatccag cctgtccttt ggaccacacc     1860

acccctccag catggtcacc gccatgggtt agagccctgc tcgatgctca cagggccccc     1920

agcgagagtc cctgcagtcc ctttcgactt gcatttttgc aggagcagta tcatgaagcc     1980

taaacgcgat ggatatatgt ttttgaaggc agaaagcaaa attatgtttg ccactttgca     2040

aaggagctca ctgtggtgtc tgtgttccaa ccactgaatc tggaccccat ctgtgaataa     2100

gccattctga ctcatatccc ctatttaaca gggtctctag tgctgtgaaa aaaaaaatgc     2160

tgaacattgc atataactta tattgtaaga aatactgtac aatgacttta ttgcatctgg     2220

gtagctgtaa ggcatgaagg atgccaagaa gtttaaggaa tatgggagaa atagtgtgga     2280

aattaagaag aaactaggtc tgatattcaa atggacaaac tgccagtttt gtttcctttc     2340

actggccaca gttgtttgat gcattaaaag aaaataaaaa aaagaaaaaa gagaaaagaa     2400

aaaaaaagaa aaaagttgta ggcgaatcat ttgttcaaag ctgttggcct ctgcaaagga     2460

aataccagtt ctgggcaatc agtgttaccg ttcaccagtt gccgttgagg gtttcagaga     2520

gcctttttct aggcctacat gctttgtgaa caagtccctg taattgttgt ttgtatgtat     2580

aattcaaagc accaaaataa gaaaagatgt agatttattt catcatatta tacagaccga     2640

actgttgtat aaatttattt actgctagtc ttaagaactg ctttctttcg tttgtttgtt     2700

tcaatatttt ccttctctct caatttttgg ttgaataaac tagattacat tcagttggcc     2760

taaggtggtt gtgctcggag ggtttcttgt ttcttttcca ttttgttttt ggatgatatt     2820

tattaaatag cttctaagag tccggcggca tctgtcttgt ccctattcct gcagcctgtg     2880

ctgagggtag cagtgtatga gctaccagcg tgcatgtcag cgaccctggc ccgacaggcc     2940

acgtcctgca atcggcccgg ctgcctcttc gccctgtcgt gttctgtgtt agtgatcact     3000

gcctttaata cagtctgttg gaataatatt ataagcataa taataaagtg aaaatatttt     3060

aaaactacaa                                                            3070


<210>  18
<211>  444
<212>  PRT
<213>  homo sapiens

<400>  18

Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro 
1               5                   10                  15      


Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser 
            20                  25                  30          


His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp 
        35                  40                  45              


Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr 
    50                  55                  60                  


Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His 
65                  70                  75                  80  


Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp 
                85                  90                  95      


Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp 
            100                 105                 110         


Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp 
145                 150                 155                 160 


Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala 
                165                 170                 175     


Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp 
            180                 185                 190         


Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu 
        195                 200                 205             


Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro 
    210                 215                 220                 


Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg 
                245                 250                 255     


Ser Ser Thr Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr 
            260                 265                 270         


Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys 
        275                 280                 285             


Gly Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro 
    290                 295                 300                 


Lys Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn 
305                 310                 315                 320 


Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp 
                325                 330                 335     


Pro Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn 
            340                 345                 350         


Arg Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys 
        355                 360                 365             


Met Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu 
    370                 375                 380                 


Asp Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His 
385                 390                 395                 400 


Met Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met 
                405                 410                 415     


Leu Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly 
            420                 425                 430         


Pro His His Pro Ser Ser Met Val Thr Ala Met Gly 
        435                 440                 


<210>  19
<211>  2575
<212>  DNA
<213>  homo sapiens

<400>  19
gggacacaga gggaggaaga agcggcggcg gcggcggcgg cggcggcggc tcctctttgc       60

agagggggaa actcttgggc tgagagcagg aataatgcgg taggcaaggc gggctgctgg      120

ctcccccggc tccggcagca gcggcggcag cccgagcagc ggcagcagca gcggcagcac      180

cccaggcgct gacagccccg ccggccggct ccgttgctga ccgccgactg tcaatggagc      240

tggaaaacat cgtggccaac acggtcttgc tgaaagccag ggaagggggc ggaggaaagc      300

gcaaagggaa aagcaagaag tggaaagaaa tcctgaagtt ccctcacatt agccagtgtg      360

aagacctccg aaggaccata gacagagatt actgcagttt atgtgacaag cagccaatcg      420

ggaggctgct tttccggcag ttttgtgaaa ccaggcctgg gctggagtgt tacattcagt      480

tcctggactc cgtggcagaa tatgaagtta ctccagatga aaaactggga gagaaaggga      540

aggaaattat gaccaagtac ctcaccccaa agtcccctgt tttcatagcc caagttggcc      600

aagacctggt ctcccagacg gaggagaagc tcctacagaa gccgtgcaaa gaactctttt      660

ctgcctgtgc acagtctgtc cacgagtacc tgaggggaga accattccac gaatatctgg      720

acagcatgtt ttttgaccgc tttctccagt ggaagtggtt ggaaaggcaa ccggtgacca      780

aaaacacttt caggcagtat cgagtgctag gaaaaggggg cttcggggag gtctgtgcct      840

gccaggttcg ggccacgggt aaaatgtatg cctgcaagcg cttggagaag aagaggatca      900

aaaagaggaa aggggagtcc atggccctca atgagaagca gatcctcgag aaggtcaaca      960

gtcagtttgt ggtcaacctg gcctatgcct acgagaccaa ggatgcactg tgcttggtcc     1020

tgaccatcat gaatgggggt gacctgaagt tccacatcta caacatgggc aaccctggct     1080

tcgaggagga gcgggccttg ttttatgcgg cagagatcct ctgcggctta gaagacctcc     1140

accgtgagaa caccgtctac cgagatctga aacctgaaaa catcctgtta gatgattatg     1200

gccacattag gatctcagac ctgggcttgg ctgtgaagat ccccgaggga gacctgatcc     1260

gcggccgggt gggcactgtt ggctacatgg ctccagaggt cctgaacaac cagaggtacg     1320

gcctgagccc cgactactgg ggccttggct gcctcatcta tgagatgatc gagggccagt     1380

cgccgttccg cggccgcaag gagaaggtga agcgggagga ggtggaccgc cgggtcctgg     1440

agacggagga ggtgtactcc cacaagttct ccgaggaggc caagtccatc tgcaagatgc     1500

tgctcacgaa agatgcgaag cagaggctgg gctgccagga ggagggggct gcagaggtca     1560

agagacaccc cttcttcagg aacatgaact tcaagcgctt agaagccggg atgttggacc     1620

ctcccttcgt tccagacccc cgcgctgtgt actgtaagga cgtgctggac atcgagcagt     1680

tctccactgt gaagggcgtc aatctggacc acacagacga cgacttctac tccaagttct     1740

ccacgggctc tgtgtccatc ccatggcaaa acgagatgat agaaacagaa tgctttaagg     1800

agctgaacgt gtttggacct aatggtaccc tcccgccaga tctgaacaga aaccaccctc     1860

cggaaccgcc caagaaaggg ctgctccaga gactcttcaa gcggcagcat cagaacaatt     1920

ccaagagttc gcccagctcc aagaccagtt ttaaccacca cataaactca aaccatgtca     1980

gctcgaactc caccggaagc agctagtttc ggctctggcc tccaagtcca cagtggaacc     2040

agcccagacc cttctcctta gaagtggaag tagtggagcc cctgctctgg tggggctgcc     2100

aggggagacc ccgggagccg gggaaggagg ccgtccatcc cgtcgacgta gaacctcgag     2160

gtttctcaaa gaaatttcca ctcaggtctg ttttccgagg cggccccggc cggggtggat     2220

tggatttgtc tttggtgaac attgcaatag aaatccaatt ggatacgaca acttgcacgt     2280

attttaatag cgtcataact agaactgaat tttgtcttta tgatttttaa agaaaagttt     2340

tgtaaatttc tctactgtct cagtttacat tttgtatatt tgtatttaaa tgaaagtgag     2400

actttgaggg tgtatatttt ctgtgcagcc actgttaagc catgtgttcc aaggcatttt     2460

agcggggagg gggttatcaa aaaaaaaaaa atgtgactca agacttccag agcctcaaat     2520

gagaaaatgt ctttattaaa tgtagaaagt gatccataaa aaaaaaaaaa aaaaa          2575


<210>  20
<211>  590
<212>  PRT
<213>  homo sapiens

<400>  20

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  21
<211>  1849
<212>  DNA
<213>  homo sapiens

<400>  21
gggttatatg atctctttgg ctttagggaa ttactccata ccagctctga gatttccagc       60

tcagcgatgc ccccaggtcc ctgggagagc tgcttctggg tggggggcct cattttgtgg      120

ctcagcgttg gaagttcagg ggatgcacct cctaccccac agccaaagtg cgctgacttc      180

cagagcgcca acctttttga aggcaccgat ctcaaagtcc agtttctcct ctttgtccct      240

tcgaatccta gctgtgggca gctagtagaa ggaagcagtg acctccaaaa ctctgggttc      300

aatgccactc tgggaaccaa actaattatc catggattca gggttttagg aacaaagcct      360

tcctggattg acacatttat tagaaccctt ctgcgtgcaa cgaatgctaa tgtgattgcc      420

gtggactgga tttatgggtc tacaggagtc tacttctcag ctgtgaaaaa tgtgattaag      480

ttgagcctcg agatctccct tttcctcaat aaactcctgg tgctgggtgt gtcggaatcc      540

tcaatccaca tcattggtgt tagcctgggg gcccacgttg ggggcatggt gggacagctc      600

ttcggaggcc agctgggaca gatcacaggc ctggaccccg ctggacctga gtacaccagg      660

gccagtgtgg aagagcgctt ggatgctgga gatgccctct tcgtggaagc catccacaca      720

gacaccgaca atttgggtat tcggattccc gttggacatg tggactactt cgtcaacgga      780

ggccaagacc aacctggctg ccccaccttc ttttacgcag gttatagtta tctgatctgt      840

gatcacatga gggctgtgca cctctacatc agcgccctgg agaattcctg tccactgatg      900

gcctttccct gtgccagcta caaggccttc cttgctggac gctgtctgga ttgctttaac      960

ccttttctgc tttcctgccc aaggatagga ctggtggaac aaggtggtgt caagatagag     1020

ccgctcccca aggaagtgaa agtctacctc ctgactactt ccagtgctcc gtactgcatg     1080

catcacagcc tcgtggagtt tcacttgaag gaactgagaa acaaggacac caacatcgag     1140

gttaccttcc ttagcagtaa catcacctct tcatctaaga tcaccatacc taagcagcaa     1200

cgctatggga aaggaatcat agcccatgcc accccacaat gccagataaa ccaagtgaaa     1260

ttcaagtttc agtcttccaa ccgagtttgg aaaaaagacc ggactaccat tattgggaag     1320

ttctgcactg cccttttgcc tgtcaatgac agagaaaaga tggtctgctt acctgaacca     1380

gtgaacttac aagcaagtgt gactgtttcc tgtgacctga agatagcctg tgtgtagttt     1440

aacctgggca ggacacatct ccctgcattt tttttttttt tttgagagag aggtgtgatg     1500

agggatgtgt gtgtgcagct tattgtagac cattactact aaggagaaaa gcaaagctct     1560

ttcttatttt cctcataatc agctaccctg gaggggaggg agaactcatt ttacagaact     1620

tggtttcctt tgccgatctt atgtacatac ccattttagc tttcccatgc atacttaact     1680

gcacttgctt tatctccttg ggcattcgta cttaggattc aatagaaaca tgtacagggt     1740

aaacaatttt ttaaaaataa aacttcatgg agtatctgaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1849


<210>  22
<211>  456
<212>  PRT
<213>  homo sapiens

<400>  22

Met Pro Pro Gly Pro Trp Glu Ser Cys Phe Trp Val Gly Gly Leu Ile 
1               5                   10                  15      


Leu Trp Leu Ser Val Gly Ser Ser Gly Asp Ala Pro Pro Thr Pro Gln 
            20                  25                  30          


Pro Lys Cys Ala Asp Phe Gln Ser Ala Asn Leu Phe Glu Gly Thr Asp 
        35                  40                  45              


Leu Lys Val Gln Phe Leu Leu Phe Val Pro Ser Asn Pro Ser Cys Gly 
    50                  55                  60                  


Gln Leu Val Glu Gly Ser Ser Asp Leu Gln Asn Ser Gly Phe Asn Ala 
65                  70                  75                  80  


Thr Leu Gly Thr Lys Leu Ile Ile His Gly Phe Arg Val Leu Gly Thr 
                85                  90                  95      


Lys Pro Ser Trp Ile Asp Thr Phe Ile Arg Thr Leu Leu Arg Ala Thr 
            100                 105                 110         


Asn Ala Asn Val Ile Ala Val Asp Trp Ile Tyr Gly Ser Thr Gly Val 
        115                 120                 125             


Tyr Phe Ser Ala Val Lys Asn Val Ile Lys Leu Ser Leu Glu Ile Ser 
    130                 135                 140                 


Leu Phe Leu Asn Lys Leu Leu Val Leu Gly Val Ser Glu Ser Ser Ile 
145                 150                 155                 160 


His Ile Ile Gly Val Ser Leu Gly Ala His Val Gly Gly Met Val Gly 
                165                 170                 175     


Gln Leu Phe Gly Gly Gln Leu Gly Gln Ile Thr Gly Leu Asp Pro Ala 
            180                 185                 190         


Gly Pro Glu Tyr Thr Arg Ala Ser Val Glu Glu Arg Leu Asp Ala Gly 
        195                 200                 205             


Asp Ala Leu Phe Val Glu Ala Ile His Thr Asp Thr Asp Asn Leu Gly 
    210                 215                 220                 


Ile Arg Ile Pro Val Gly His Val Asp Tyr Phe Val Asn Gly Gly Gln 
225                 230                 235                 240 


Asp Gln Pro Gly Cys Pro Thr Phe Phe Tyr Ala Gly Tyr Ser Tyr Leu 
                245                 250                 255     


Ile Cys Asp His Met Arg Ala Val His Leu Tyr Ile Ser Ala Leu Glu 
            260                 265                 270         


Asn Ser Cys Pro Leu Met Ala Phe Pro Cys Ala Ser Tyr Lys Ala Phe 
        275                 280                 285             


Leu Ala Gly Arg Cys Leu Asp Cys Phe Asn Pro Phe Leu Leu Ser Cys 
    290                 295                 300                 


Pro Arg Ile Gly Leu Val Glu Gln Gly Gly Val Lys Ile Glu Pro Leu 
305                 310                 315                 320 


Pro Lys Glu Val Lys Val Tyr Leu Leu Thr Thr Ser Ser Ala Pro Tyr 
                325                 330                 335     


Cys Met His His Ser Leu Val Glu Phe His Leu Lys Glu Leu Arg Asn 
            340                 345                 350         


Lys Asp Thr Asn Ile Glu Val Thr Phe Leu Ser Ser Asn Ile Thr Ser 
        355                 360                 365             


Ser Ser Lys Ile Thr Ile Pro Lys Gln Gln Arg Tyr Gly Lys Gly Ile 
    370                 375                 380                 


Ile Ala His Ala Thr Pro Gln Cys Gln Ile Asn Gln Val Lys Phe Lys 
385                 390                 395                 400 


Phe Gln Ser Ser Asn Arg Val Trp Lys Lys Asp Arg Thr Thr Ile Ile 
                405                 410                 415     


Gly Lys Phe Cys Thr Ala Leu Leu Pro Val Asn Asp Arg Glu Lys Met 
            420                 425                 430         


Val Cys Leu Pro Glu Pro Val Asn Leu Gln Ala Ser Val Thr Val Ser 
        435                 440                 445             


Cys Asp Leu Lys Ile Ala Cys Val 
    450                 455     


<210>  23
<211>  8931
<212>  DNA
<213>  homo sapiens

<400>  23
cttcccgcac tgcttgggga gagctggtga gcaagagtct ggcccgagtt agctagagct       60

gttgccatga caagcatttt cttaagaaag ctctgctgtt gagatcgtcc aaagctgggg      120

gctgggaggg ggggcacgaa cttcgtgggg caccatccct ccgaagagag caagatcaga      180

gacacccgcc cagctctcct gcaccctttt tctttcagga acctgagagg tccttcccat      240

tggaggggca gggggaggag acccagccca ctccccggcc ttagccagaa aggcaagaga      300

gcaaagccag cgtctctagc ttggttgcca cactggggag actggtgggt ggtcacccca      360

ccctaccctc atccatggaa acccggaggg agagtcccgc ctgaagaaac ctggatcttt      420

gctagaaaga gagagatcca gttgtcatcg gtatccagga agctctcctc ttcctcctcc      480

tgacgtctac tactacagtt gctggttgtt gctaaggttg ctgccatggt aacatgcaca      540

tcctgtttac accttcatct gggcaagttg gtctaagcta ggaacctacc taccctggac      600

aactactatc atcaccacct ggggacacca atcatcgtga cacggagtcc accttccact      660

cagttccccc atcctcttcc tcctctcgct gccagacttc atacggaaga aaggatctag      720

acttcggacg gctactcggg agcttattgc acaagatata ttcaatctat tccctcactg      780

ggcccccaga gaagcaagaa gtaggaagaa gttgagacag ggaggcagga gacactggtc      840

agttgaaggg aaacgctaca tcttctctgg ttgaggggct tggtaacagc aggcaaaatg      900

acgaacccat cagaccgtgt cttgcctgcc aactcgatgg ccgagagccg tgaaggggac      960

tttggctgca cagtaatgga actgaggaag ctcatggagc tgcgttcaag ggatgcactg     1020

acccagatta atgtccacta tggaggtgta cagaatctct gcagtagact gaaaacctcc     1080

cctgtggaag gtctgtctgg gaaccctgca gatctggaga aacgtaggca ggtgtttgga     1140

cacaacgtga tcccccccaa aaagcccaag actttcttag aattagtgtg ggaagctctt     1200

caagatgtca cgcttatcat cctggagatt gcagccatca tctccctggt cctgtccttt     1260

tatcgccctg ctggtgaaga aaatgaactg tgtggtcaag tcgcaactac cccagaagat     1320

gaaaatgagg cacaagctgg ctggattgag ggggcagcca tccttttctc agtgatcatc     1380

gtggtgttag tgactgcctt taatgattgg agcaaagaga agcaattccg ggggctgcag     1440

tgccgcattg aacaggagca aaagttctcc atcatccgaa acggtcaact catccagctc     1500

cctgtggctg agattgtggt tggtgatatt gcccaagtca aatacggtga tctgctgcct     1560

gcagatggaa tcctgatcca agggaatgat ctgaagattg atgagagctc tctgacaggg     1620

gaatctgacc atgtcaagaa gtccctggac aaagacccca tgttgctctc agggacccat     1680

gtcatggaag gttctggccg gatggtggtg acagctgttg gtgtcaactc tcagactgga     1740

atcatcctta ctctcttggg ggtcaatgag gatgacgaag gggagaaaaa gaagaaaggt     1800

aaaaaacaag gagtccctga aaatcgcaac aaagcaaaga cccaagacgg agtggccctg     1860

gaaatccagc cactcaacag ccaggaggga atcgacaatg aggaaaagga caagaaggca     1920

gtcaaggtgc ctaaaaagga gaagtcagtg ctgcagggca agctgactcg cctggctgtt     1980

cagattggga aagccggtct gctcatgtct gctctcacgg ttttcatcct gattctatac     2040

tttgtgattg acaactttgt gataaatcgc agaccatggc tccctgagtg tactcccatc     2100

tacatccagt actttgtcaa gttcttcatc atcggcatca ctgtactggt ggtggctgtg     2160

ccagaggggc tgcctctggc tgtcaccatc tcactggcct actctgtgaa gaaaatgatg     2220

aaagacaata acctagtacg gcacttggat gcttgtgaga ccatgggcaa cgccaccgcc     2280

atctgctctg ataagacagg cacgttgacc atgaaccgca tgactgtggt acaagcttat     2340

attgggggca tccattaccg tcaaatccca agccctgatg tcttcctgcc caaagtcctg     2400

gacctcattg tcaatggcat ttctatcaac agtgcttata cctccaagat tctgcctcca     2460

gagaaggagg gaggcctgcc tcggcaggtg ggcaacaaga ccgagtgtgc tctgctaggc     2520

tttgtcacag atctgaagca ggattatcag gctgtgcgta atgaagtgcc cgaggagaag     2580

ctctacaagg tgtacacctt taactcagtg cgcaagtcaa tgagcaccgt catcaggaat     2640

cccaacggtg gcttccgtat gtacagcaag ggcgcctctg agatcatctt gcgcaagtgt     2700

aatcgaatcc tggaccggaa aggggaagca gtgccattca agaataaaga cagagatgat     2760

atggtacgca ctgtcatcga gcccatggcc tgtgatggac tccggactat ctgcatagct     2820

taccgggact tcgatgacac agagccctct tgggacaatg agaatgagat cctcaccgaa     2880

ctgacctgta tcgcggtggt gggcattgag gaccctgtgc gcccagaggt gccagatgct     2940

attgccaaat gcaaacaagc tggcattact gtcagaatgg tgacaggtga caacatcaac     3000

acagcccggg ccattgccac caaatgtggc attctgacac ctggggatga cttcctgtgc     3060

ttagaaggca aagaattcaa ccggctcatc cgcaacgaga aaggcgaggt agagcaagaa     3120

aagctggaca agatctggcc taagcttcgg gtcctggcgc gatcttctcc cactgacaag     3180

cacaccctgg tgaaaggcat aattgacagc actgttgggg aacaccggca ggtcgtggct     3240

gtcactggtg atggcacaaa tgacgggcct gctctgaaga aagcggatgt tggttttgcc     3300

atgggcatcg caggcacaga tgtagcaaag gaggcttcag acatcatcct aacagatgac     3360

aacttcacca gcattgtgaa ggcagtgatg tggggacgaa atgtctatga cagcatctcc     3420

aagttcctgc agttccagct cactgtcaat gtggtggccg tgattgtagc cttcactgga     3480

gcctgtatca ctcaggattc cccattgaaa gctgtgcaga tgttgtgggt taatctgatc     3540

atggacactt ttgcttcatt ggccctggcc acagagcccc ctacggaatc tctgttgaag     3600

cggcgcccct atggccgaaa taagcctctg atctcacgca ctatgatgaa gaacatcttg     3660

ggccatgcat tctatcagct cattgtcatc tttatccttg tctttgcggg tgagaaattc     3720

tttgatattg atagtgggag gaaggcacct ctacattcac cacccagcca gcactatacc     3780

attgttttta acaccttcgt gctgatgcag ctcttcaatg aaatcaactc ccgaaagatc     3840

catggagaga agaacgtctt ttcaggcatc taccgcaaca ttatcttctg ctctgtagtc     3900

ttgggcacat tcatctgcca gattttcatc gtggaatttg ggggtaaacc cttcagttgt     3960

acaagcctca gcctgtctca gtggctgtgg tgtctcttca ttgggattgg agaacttctg     4020

tggggccagt tcatctccgc aatacctacc cgatccctga agttcctgaa ggaggctggg     4080

catggcacca ccaaagagga gatcaccaag gatgccgagg gactggatga gattgaccat     4140

gctgagatgg agctgcgccg aggccagatc ctctggttcc ggggcctgaa ccgtatccag     4200

actcagatcg acgtaattaa cacattccag acgggagcct cttttaaggg agtcctaagg     4260

cgacagaaca tgggtcaaca ccttgatgta aaacttgttc ctagttcatc ctatgtagca     4320

gttgcaccag tcaaatcttc ccccaccact tctgttcctg ctgtttcatc tcctcctatg     4380

ggcaatcaaa gtggtcaaag cgttccatag ttccctccac gaaagcattc agaaacccta     4440

caaccaaaag tccatccaca gcttcatgac ccaccctgaa ttcgccatag aggaggagtt     4500

gccacgaaca ccactcctgg atgaggaaga ggaggaaaat cctgacaagg cttctaagtt     4560

tgggactagg gtgctcctgt tggatggtga ggtcactcca tatgccaata caaacaacaa     4620

tgcggtggat tgcaaccaag tgcagctccc ccagtcggac agctctctac agagcctaga     4680

gacatcagtt tgaattttct ttctctgact ctcatcccta ttttacctat ttccattttc     4740

gtctatccca tctatgaggt gatgatggga cttttcattg tcacgtcagc tgctgtgtta     4800

acagcagtgt gtgtgaagtg aacctctacc tgaccatgaa gaggcaagag cacagactta     4860

caaggatttc aacttaagct tgacttgggg tttgtagcgg gacccagtca aaccccattc     4920

aggtcatggt agaatctact ccttggtagt cacttgtcat ttttaaagaa atgatgacaa     4980

tcctcttggc atcaccccac cccacattct ccccgatgtt cctctcctga attctggatt     5040

ttgtcctaca agtctgtgcc atttataagc taagttgagg gttcagaggg agacaaatat     5100

ccccaagtga aatatgttgc ggtagagatg gaatgtataa aatccgccag tagtgtgatt     5160

gtttttcaat ttttcccact ttgaaaactt acacctaaag gcctgtaggc ctctaactct     5220

ttctgccctt tcattcaaac ctctccaaag ttctttgtct tttgtcttcc cttcctttcc     5280

tttttttttt ttttttttat gatgattaag aaaatggaaa ggatatggat gaattgtgta     5340

aacttagatc cttctccctt ttggcccaaa agaacccttg atttagttcc agaatccaac     5400

cagtttcttt gttaaaaggg tccttttgaa gcaattaagt gctggtaaga atatttctct     5460

gttgttgcca ggttaccttc tgcttttaaa ttgccatctt gtaaagtgta tgtggttctt     5520

aagtgccagg gagatcagcc ttgcccatga aggttgcata tgtgtggtat acagttttta     5580

cctgaaagcc tgagctttct cttattccta aagtggtggc aaaagaatga actgggtatg     5640

accctgcccc cttactgggc ttggatattg aggaccagac gctgccaaat ctaggacaag     5700

acagaccatc aaagcagact tttgtgggct cctctttggg gtgaccactg ctttcaaagc     5760

catctgccaa ggctctccag ggcaggacct gactggtggg gaatgagtgt tcagaagcct     5820

tgggagaggc caaagagcca ttctagcatg atctgagaaa accttcctgc agaggccaga     5880

aaccttgagc ttaggtgcct ggggaccagc ttcgacattc tctccagttt ctgattctaa     5940

tttttgccac gtgtcacaac ttttccagtc tctgagaagg tcccagcctt tctcaaatat     6000

tctgattttg aaaatatgta tccaaagtgg gaggcccctg tgacattttg ccaacttaaa     6060

cgagaaaaag accccccgca cccggcacac tcccccttcc tccagccccg cttcagccac     6120

atgctccagc tgctgcccag taaagccctg tgcctttttt tcccctgaat actgcccaaa     6180

gcatcccctt cccatctgcc tctcaggagt tggggacttt gctaggagat tttttaagtg     6240

ttccttactg ggacaacgtg gagccacgtt tgcaggagct ccatttgtat ccctgctggt     6300

gttgacttct gtgtaggggc cagttcatgt ccctgactct cacctcccat tagataaatg     6360

aagcccaccc ccctttctag agtgatgaga gtcaagaaga ggggatgtat gaacggccaa     6420

attcccatgt gagaggaaga tgacctgatc cacctagcct tttcttctgg atctgtcctc     6480

cctcacccct ttcacctgag ctgtccacag taggaaacat aaagaaacaa tgtcccctac     6540

atatccccat gactacataa tccatcatcg taggaaatag gaaagcaaat ttgattttgg     6600

ttttgtaaaa cgtacatgct tcaataattc ttttttgtgt cttaaatact cataggggaa     6660

aaaaacagct cacccaaggt gttaggtttc acatatatat tcatcaacta ttttagaaga     6720

tttaattcta tcaaatcttg tattacctca gatcatttta aatagcaagc caataacgag     6780

ctttgaaggc tattttacca ttcctgttca caaaaggttc tcatggtgcc tgacaggtta     6840

cccttgaggg cttgtgtcta ctttttaaaa gtcaatggtt ttttttcttg tgttctagtt     6900

tccataatag gagagaaaat atagaaatat atgcaaaaat tatagttttc tttagatcag     6960

aaactgatat ttttgggtca gccatatgta ttttgtttaa aggatttaaa ataaagtgcc     7020

gtcatgtagc cctgtggaag ggagcacata accagctgtt tggcatgaca ggtgacttag     7080

tatatttgta attggtttta aaaccaatac accatacttt ctttctgcaa acagccatct     7140

ttatacttag ggaagaaaaa ttgttgggtt ctagactttt ttaatataaa ttttgttgat     7200

atggaattag gtaagtttaa gtgtctatgt gcatatgttt tttatataag ttttttctat     7260

tcagtttcac tgatccaact ggcagtgggt aaatatggca taagttaata acacttttcc     7320

ccaaaatggt gctttggatt tgaaaagggt ctgatgggga gaaggagaac gtatcatcct     7380

agcttcctct cttaataaac ctagaaaaac gggtagtaaa ctgtggatag tcaggaaaac     7440

acccagcaag ggacacagct gtcaggaaat gaatcttccc cccaaccccc accatgcaga     7500

tggatagaca gaatctttcc tgactagtca ttaggatcag gggcctctgt tggatttgtg     7560

tttcttgaag aatagctggc agagtggtat aaaagacacg aatatctcct ggtctataag     7620

gatactctga tttggggttt gcatttttca tggtttttat ttcctgttcc ccctggagtt     7680

ttccattagt gagtttttgt gcaaggatct tatttgtgat gccttccctc ccctagaaag     7740

attttgtgca atatattaaa tggggacaga attctaaatg gataaaacaa tggctggttc     7800

tagccctgag tgacagtctt aaggctagat ccttcccata gtatcatctg tcctctggaa     7860

tgactctcct gtccctaaag gggttaagag agagatcacc tagaaatccc tctggacact     7920

tgtgggttct ttagggtttg agtttcttct tccccttgag cttcagagag gagagttggc     7980

atggttaaat ctgaatggtt acctcactgc tgaaaaccca gaggggcgtg gcacactcgc     8040

ttgtgtggaa aagcctctaa atgcatccct tcctttcttt cctgcttcct ttgccttaca     8100

attgaagcag cccgtggtac catcacagta tgcagagact tcctcacctt tcatatctag     8160

ggaccacccc cgatgcattg gtgagggtgg gcacttataa atgcctgcta ttgttaagcc     8220

attccagcct cttcctctga atagaccaga cgccctttca cttagttcag tgccagtcct     8280

tttgccttcc caaccctgct gttaggcctg ctgttccctt tgctcttgat taggagagat     8340

ggaaggagat gagctcccat aactgaattg gcctttggtt catgttttct ccccatatgt     8400

atatatgcca tatgtgaata tgccatatat atgtgccaac aaatctatct acgttgttct     8460

tttcaaatta gcacgcagat aggaattttg agtttcttct tcttttagta actagtataa     8520

caagcactgg tatttttgta caaaaaagaa aaacaaaaga ttgactattg tggtctgcat     8580

gacataaaca aacaaatggt gatatcaaag caacgtatac cccagtccag tgtgtgttgc     8640

cataatttgc aattcagctt aacagtgcac ccaatctata tttgcatttt gatattattt     8700

aagctctatg tacaaggttt tgcatgtatt tatatggttc ttagggaaaa aaaatgctat     8760

aaactgcaaa tctgaaattc aaatgtgttg ttccactgag accagaagaa gaagaggagt     8820

tttaaaaggg ataatttgtt ggagccaata aagctttttg ctgatgaaca gaaaccaata     8880

ctgctgtgca ctgagaataa aaactcatgc ccacttgtaa aaaaaaaaaa a              8931


<210>  24
<211>  1170
<212>  PRT
<213>  homo sapiens

<400>  24

Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu 
            20                  25                  30          


Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr 
        35                  40                  45              


Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe 
65                  70                  75                  80  


Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu 
                85                  90                  95      


Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala 
            100                 105                 110         


Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu 
        115                 120                 125             


Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu 
    130                 135                 140                 


Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile 
145                 150                 155                 160 


Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln 
                165                 170                 175     


Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile 
            180                 185                 190         


Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val 
        195                 200                 205             


Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly 
    210                 215                 220                 


Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr 
225                 230                 235                 240 


Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu 
                245                 250                 255     


Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr 
            260                 265                 270         


Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly 
        275                 280                 285             


Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln 
    290                 295                 300                 


Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala 
305                 310                 315                 320 


Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu 
                325                 330                 335     


Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu 
            340                 345                 350         


Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu 
        355                 360                 365             


Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile 
    370                 375                 380                 


Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro 
385                 390                 395                 400 


Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val 
                405                 410                 415     


Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser 
            420                 425                 430         


Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg 
        435                 440                 445             


His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser 
    450                 455                 460                 


Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala 
465                 470                 475                 480 


Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe 
                485                 490                 495     


Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser 
            500                 505                 510         


Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro 
        515                 520                 525             


Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr 
    530                 535                 540                 


Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu 
545                 550                 555                 560 


Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser 
                565                 570                 575     


Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly 
            580                 585                 590         


Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys 
        595                 600                 605             


Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg 
    610                 615                 620                 


Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile 
625                 630                 635                 640 


Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn 
                645                 650                 655     


Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp 
            660                 665                 670         


Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala 
        675                 680                 685             


Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg 
    690                 695                 700                 


Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu 
705                 710                 715                 720 


Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly 
                725                 730                 735     


Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val 
            740                 745                 750         


Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile 
        755                 760                 765             


Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly 
    770                 775                 780                 


Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe 
785                 790                 795                 800 


Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile 
                805                 810                 815     


Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp 
            820                 825                 830         


Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu 
        835                 840                 845             


Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile 
    850                 855                 860                 


Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu 
865                 870                 875                 880 


Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr 
                885                 890                 895     


Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile 
            900                 905                 910         


Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu 
        915                 920                 925             


Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile 
    930                 935                 940                 


Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr 
945                 950                 955                 960 


Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile 
                965                 970                 975     


Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr 
            980                 985                 990         


Arg Asn Ile Ile Phe Cys Ser Val  Val Leu Gly Thr Phe  Ile Cys Gln 
        995                 1000                 1005             


Ile Phe  Ile Val Glu Phe Gly  Gly Lys Pro Phe Ser  Cys Thr Ser 
    1010                 1015                 1020             


Leu Ser  Leu Ser Gln Trp Leu  Trp Cys Leu Phe Ile  Gly Ile Gly 
    1025                 1030                 1035             


Glu Leu  Leu Trp Gly Gln Phe  Ile Ser Ala Ile Pro  Thr Arg Ser 
    1040                 1045                 1050             


Leu Lys  Phe Leu Lys Glu Ala  Gly His Gly Thr Thr  Lys Glu Glu 
    1055                 1060                 1065             


Ile Thr  Lys Asp Ala Glu Gly  Leu Asp Glu Ile Asp  His Ala Glu 
    1070                 1075                 1080             


Met Glu  Leu Arg Arg Gly Gln  Ile Leu Trp Phe Arg  Gly Leu Asn 
    1085                 1090                 1095             


Arg Ile  Gln Thr Gln Ile Asp  Val Ile Asn Thr Phe  Gln Thr Gly 
    1100                 1105                 1110             


Ala Ser  Phe Lys Gly Val Leu  Arg Arg Gln Asn Met  Gly Gln His 
    1115                 1120                 1125             


Leu Asp  Val Lys Leu Val Pro  Ser Ser Ser Tyr Val  Ala Val Ala 
    1130                 1135                 1140             


Pro Val  Lys Ser Ser Pro Thr  Thr Ser Val Pro Ala  Val Ser Ser 
    1145                 1150                 1155             


Pro Pro  Met Gly Asn Gln Ser  Gly Gln Ser Val Pro  
    1160                 1165                 1170 


<210>  25
<211>  3620
<212>  DNA
<213>  homo sapiens

<400>  25
acctcgcagt ctccccaggt ccgcccagca gccgcgcttc agccagaata ctgggatctt       60

cagtggcagg aggagtaatc agaagacgga gatgaatttt aacactattt tggaggagat      120

tcttattaaa aggtcacagc agaaaaagaa gacatcgccc ttaaactaca aagagagact      180

ttttgtactt acaaagtcca tgctaaccta ctatgagggt cgagcagaga agaaatacag      240

aaaggggttt attgatgttt caaaaatcaa gtgtgtggaa atagtgaaga atgatgatgg      300

tgtcattccc tgtcaaaata agtatccatt tcaggttgtt catgatgcta acacacttta      360

catttttgca cctagtccac aaagcaggga cctgtgggtg aagaagttaa aagaagaaat      420

aaagaacaac aataatatta tgattaaata tcatcctaaa ttctggacag atggaagtta      480

tcagtgttgt agacaaactg aaaaattagc acccggatgt gaaaaataca atctttttga      540

gagcagtata agaaaagcac tacctccagc accagaaaca aagaagcgaa ggcctccccc      600

accaattcca ctagaagaag aagataatag tgaagaaatc gttgtagcca tgtatgattt      660

ccaagcagca gaaggacatg atctcagatt agagagaggc caagagtatc tcattttaga      720

aaagaatgat gttcattggt ggagagcaag agataaatat gggaatgaag gatatatccc      780

aagtaattac gtaacgggaa agaaatcaaa caacttagat caatatgaat ggtattgcag      840

aaatatgaat agaagcaagg cagagcaact cctccgcagt gaagataaag aaggtggttt      900

tatggtaagg gattccagtc aaccaggctt gtacacagtc tccctttata ccaagtttgg      960

aggagaaggt tcatcgggtt ttaggcatta tcatataaag gaaacaacaa catctccaaa     1020

gaagtattac ctagctgaaa aacatgcttt tggctccatt cctgagatta ttgaatatca     1080

taagcacaat gcagcaggac ttgtcaccag gcttcggtac ccagttagtg tgaaagggaa     1140

gaatgcaccc accactgcag gattcagcta tgagaaatgg gagattaacc cttcagaact     1200

gacctttatg agggaattgg gaagtggact gtttggagtg gtgaggcttg gcaaatggcg     1260

agcccagtac aaagtcgcaa tcaaagctat tcgggaaggt gcaatgtgcg aggaggactt     1320

tatagaagaa gctaaagtga tgatgaaact gacacacccg aagttagtgc agctttatgg     1380

tgtgtgcacc cagcagaaac caatatacat tgttactgag ttcatggaaa ggggctgcct     1440

tctgaatttc ctccgacaga gacaaggtca tttcagtaga gacgtactgc tgagcatgtg     1500

tcaggatgtg tgtgaaggga tggagtatct ggagagaaac agcttcatcc acagagatct     1560

ggctgccaga aattgtctag taagtgaggc gggagttgta aaagtatctg attttggaat     1620

ggccaggtat gttctggatg atcagtacac aagttcttct ggtgctaagt ttcctgtgaa     1680

gtggtgtcca cctgaagtgt ttaattacag ccgcttcagc agcaaatcag atgtctggtc     1740

atttggtgtt ttaatgtggg aagtattcac ggaaggcaga atgccttttg aaaaatacac     1800

caattatgaa gtggtaacca tggttactcg aggccaccga ctctaccagc cgaagttggc     1860

gtccaactat gtgtatgagg tgatgctgag atgttggcag gagaaaccag agggaaggcc     1920

ttctttcgaa gatctgctgc gcacaataga tgaactagtt gaatgtgaag aaacttttgg     1980

aagataagtg atgtgtgacc agtggctccc agattcccaa gcacaaggaa ggatgggcat     2040

tttgtggctt ttaatttatt gagcacttgg acatgtagat cattttactt atacagtgga     2100

aacacataaa taatttgctt ctagaccagc ctctgtctag acttgcttct agacagaatc     2160

tcccagagtg tggaaatgtt gccttagaaa tggtgattaa aatcactcat ttctattcat     2220

tcctcaggca cttgagtgac agttgtttac caggcactgt gtgtagcccc agggtttggc     2280

cattcagggg tgcacacatg ggaccatgtt agctgatgcc agttgaaggc cagggtattt     2340

gggaagggga agggtattag agtcatgacc aagcaaccct tctttttccc tttgacttct     2400

acagaaatct gggcctgaga cattgtctac aattgggttc tagatacatc aggaacccat     2460

cttggataaa taaataccta tcttttgttt tgaaaacatc tcagttttca agactgctct     2520

tagtattaca tgaacaatat ttgtatgctg tatatattgt aaatatatat aatatataaa     2580

gttatatatt tatgagaaac acgaattgtc ttttaattga aacttttaat cctgtagtat     2640

aggagttcac cttcttagga ctagagactg tgccttatag ctgttaattc atttccccct     2700

gaacatcaaa tatgcctgaa gagaagaaag tctagattct tctatgagta acgccccctc     2760

ctcactcagg taaatgtgtc tggggatgcc tgtccagctt aaccacgtgc atttggccta     2820

tgtaatcctg cccatggtgg ccgcagctaa tcagaatcag atggaaaatt aaaccgggta     2880

atctacttct aagccttaag aatattccct gggacacaga cactataatt ggaagtgctg     2940

agctctgggg cagaaggatc aggtgacctt cgcaacaaag tttgccccca cctcacatag     3000

gacccggaag cagcctgagc tgtggcggag gatccaggaa gctacggaga gaagcagcca     3060

gcatggtgtt ccgtgcctcc cggacgtttt tcaggaggcc tggttggact tgggttcctg     3120

gatggtggga ttgttgtaca gcctctcagg agaccctgct gtcaagactg tgtgtgtgga     3180

tttctcaccc ttagaagctc tactaagaca tcaacggaat tagggccttc ctttttgcct     3240

tgtgagcgcc aaggaaaaga aactatctcg gtcacgtgag cgccagcgaa aagaaactgt     3300

atcagtcatc cagagaccgt ttattgccca acacgttatt cttgctgttg gtggggtaac     3360

tagccgagga agacacagcg ccttcccttc aggagttgcg tctcctctgc aggccacgat     3420

ggtctgctct ggagcattgg gtgaacacac aggctggctg ctctgggcag cgccttcact     3480

ctgaccctgg agaaccattt catttcatcc tggtcagtct agagtctgtg caccaggcag     3540

tccatccact gaaggctgtg tttattcttt tcctgtgccc ctcataatgg aagaaagtaa     3600

actgcttatc ccgagcctta                                                 3620


<210>  26
<211>  631
<212>  PRT
<213>  homo sapiens

<400>  26

Met Asn Phe Asn Thr Ile Leu Glu Glu Ile Leu Ile Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Thr Ser Pro Leu Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Ser Met Leu Thr Tyr Tyr Glu Gly Arg Ala Glu Lys Lys 
        35                  40                  45              


Tyr Arg Lys Gly Phe Ile Asp Val Ser Lys Ile Lys Cys Val Glu Ile 
    50                  55                  60                  


Val Lys Asn Asp Asp Gly Val Ile Pro Cys Gln Asn Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Ala Asn Thr Leu Tyr Ile Phe Ala Pro Ser Pro 
                85                  90                  95      


Gln Ser Arg Asp Leu Trp Val Lys Lys Leu Lys Glu Glu Ile Lys Asn 
            100                 105                 110         


Asn Asn Asn Ile Met Ile Lys Tyr His Pro Lys Phe Trp Thr Asp Gly 
        115                 120                 125             


Ser Tyr Gln Cys Cys Arg Gln Thr Glu Lys Leu Ala Pro Gly Cys Glu 
    130                 135                 140                 


Lys Tyr Asn Leu Phe Glu Ser Ser Ile Arg Lys Ala Leu Pro Pro Ala 
145                 150                 155                 160 


Pro Glu Thr Lys Lys Arg Arg Pro Pro Pro Pro Ile Pro Leu Glu Glu 
                165                 170                 175     


Glu Asp Asn Ser Glu Glu Ile Val Val Ala Met Tyr Asp Phe Gln Ala 
            180                 185                 190         


Ala Glu Gly His Asp Leu Arg Leu Glu Arg Gly Gln Glu Tyr Leu Ile 
        195                 200                 205             


Leu Glu Lys Asn Asp Val His Trp Trp Arg Ala Arg Asp Lys Tyr Gly 
    210                 215                 220                 


Asn Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Gly Lys Lys Ser Asn 
225                 230                 235                 240 


Asn Leu Asp Gln Tyr Glu Trp Tyr Cys Arg Asn Met Asn Arg Ser Lys 
                245                 250                 255     


Ala Glu Gln Leu Leu Arg Ser Glu Asp Lys Glu Gly Gly Phe Met Val 
            260                 265                 270         


Arg Asp Ser Ser Gln Pro Gly Leu Tyr Thr Val Ser Leu Tyr Thr Lys 
        275                 280                 285             


Phe Gly Gly Glu Gly Ser Ser Gly Phe Arg His Tyr His Ile Lys Glu 
    290                 295                 300                 


Thr Thr Thr Ser Pro Lys Lys Tyr Tyr Leu Ala Glu Lys His Ala Phe 
305                 310                 315                 320 


Gly Ser Ile Pro Glu Ile Ile Glu Tyr His Lys His Asn Ala Ala Gly 
                325                 330                 335     


Leu Val Thr Arg Leu Arg Tyr Pro Val Ser Val Lys Gly Lys Asn Ala 
            340                 345                 350         


Pro Thr Thr Ala Gly Phe Ser Tyr Glu Lys Trp Glu Ile Asn Pro Ser 
        355                 360                 365             


Glu Leu Thr Phe Met Arg Glu Leu Gly Ser Gly Leu Phe Gly Val Val 
    370                 375                 380                 


Arg Leu Gly Lys Trp Arg Ala Gln Tyr Lys Val Ala Ile Lys Ala Ile 
385                 390                 395                 400 


Arg Glu Gly Ala Met Cys Glu Glu Asp Phe Ile Glu Glu Ala Lys Val 
                405                 410                 415     


Met Met Lys Leu Thr His Pro Lys Leu Val Gln Leu Tyr Gly Val Cys 
            420                 425                 430         


Thr Gln Gln Lys Pro Ile Tyr Ile Val Thr Glu Phe Met Glu Arg Gly 
        435                 440                 445             


Cys Leu Leu Asn Phe Leu Arg Gln Arg Gln Gly His Phe Ser Arg Asp 
    450                 455                 460                 


Val Leu Leu Ser Met Cys Gln Asp Val Cys Glu Gly Met Glu Tyr Leu 
465                 470                 475                 480 


Glu Arg Asn Ser Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
                485                 490                 495     


Val Ser Glu Ala Gly Val Val Lys Val Ser Asp Phe Gly Met Ala Arg 
            500                 505                 510         


Tyr Val Leu Asp Asp Gln Tyr Thr Ser Ser Ser Gly Ala Lys Phe Pro 
        515                 520                 525             


Val Lys Trp Cys Pro Pro Glu Val Phe Asn Tyr Ser Arg Phe Ser Ser 
    530                 535                 540                 


Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Val Phe Thr 
545                 550                 555                 560 


Glu Gly Arg Met Pro Phe Glu Lys Tyr Thr Asn Tyr Glu Val Val Thr 
                565                 570                 575     


Met Val Thr Arg Gly His Arg Leu Tyr Gln Pro Lys Leu Ala Ser Asn 
            580                 585                 590         


Tyr Val Tyr Glu Val Met Leu Arg Cys Trp Gln Glu Lys Pro Glu Gly 
        595                 600                 605             


Arg Pro Ser Phe Glu Asp Leu Leu Arg Thr Ile Asp Glu Leu Val Glu 
    610                 615                 620                 


Cys Glu Glu Thr Phe Gly Arg 
625                 630     


<210>  27
<211>  7889
<212>  DNA
<213>  homo sapiens

<400>  27
gtgcaggctg ctcccggggt aggtgaggga agcgcggagg cggcgcgcgg gggcagtggt       60

cggcgagcag cgcggtcctc gctaggggcg cccacccgtc agtctctccg gcgcgagccg      120

ccgccaccgc ccgcgccgga gtcaggcccc tgggccccca ggctcaagca gcgaagcggc      180

ctccggggga cgccgctagg cgagaggaac gcgccggtgc ccttgccttc gccgtgaccc      240

agcgtgcggg cggcgggatg agagggagcc atcgggccgc gccggccctg cggccccggg      300

ggcggctctg gcccgtgctg gccgtgctgg cggcggccgc cgcggcgggc tgtgcccagg      360

cagccatgga cgagtgcacg gacgagggcg ggcggccgca gcgctgcatg cccgagttcg      420

tcaacgccgc cttcaacgtg actgtggtgg ccaccaacac gtgtgggact ccgcccgagg      480

aatactgtgt gcagaccggg gtgaccgggg tcaccaagtc ctgtcacctg tgcgacgccg      540

ggcagcccca cctgcagcac ggggcagcct tcctgaccga ctacaacaac caggccgaca      600

ccacctggtg gcaaagccag accatgctgg ccggggtgca gtaccccagc tccatcaacc      660

tcacgctgca cctgggaaaa gcttttgaca tcacctatgt gcgtctcaag ttccacacca      720

gccgcccgga gagctttgcc atttacaagc gcacacggga agacgggccc tggattcctt      780

accagtacta cagtggttcc tgtgagaaca cctactccaa ggcaaaccgc ggcttcatca      840

ggacaggagg ggacgagcag caggccttgt gtactgatga attcagtgac atttctcccc      900

tcactggggg caacgtggcc ttttctaccc tggaaggaag gcccagcgcc tataactttg      960

acaatagccc tgtgctgcag gaatgggtaa ctgccactga catcagagta actcttaatc     1020

gcctgaacac ttttggagat gaagtgttta acgatcccaa agttctcaag tcctattatt     1080

atgccatctc tgattttgct gtaggtggca gatgtaaatg taatggacac gcaagcgagt     1140

gtatgaagaa cgaatttgat aagctggtgt gtaattgcaa acataacaca tatggagtag     1200

actgtgaaaa gtgtcttcct ttcttcaatg accggccgtg gaggagggca actgcggaaa     1260

gtgccagtga atgcctgccc tgtgattgca atggtcgatc ccaggaatgc tacttcgacc     1320

ctgaactcta tcgttccact ggccatgggg gccactgtac caactgccag gataacacag     1380

atggcgccca ctgtgagagg tgccgagaga acttcttccg ccttggcaac aatgaagcct     1440

gctcttcatg ccactgtagt cctgtgggct ctctaagcac acagtgtgat agttacggca     1500

gatgcagctg taagccagga gtgatggggg acaaatgtga ccgttgccag cctggattcc     1560

attctctcac tgaagcagga tgcaggccat gctcttgtga tccctctggc agcatagatg     1620

aatgtaatat tgaaacagga agatgtgttt gcaaagacaa tgtcgaaggc ttcaattgtg     1680

aaagatgcaa acctggattt tttaatctgg aatcatctaa tcctcggggt tgcacaccct     1740

gcttctgctt tgggcattct tctgtctgta caaacgctgt tggctacagt gtttattcta     1800

tctcctctac ctttcagatt gatgaggatg ggtggcgtgc ggaacagaga gatggctctg     1860

aagcatctct cgagtggtcc tctgagaggc aagatatcgc cgtgatctca gacagctact     1920

ttcctcggta cttcattgct cctgcaaagt tcttgggcaa gcaggtgttg agttatggtc     1980

agaacctctc cttctccttt cgagtggaca ggcgagatac tcgcctctct gcagaagacc     2040

ttgtgcttga gggagctggc ttaagagtat ctgtaccctt gatcgctcag ggcaattcct     2100

atccaagtga gaccactgtg aagtatgtct tcaggctcca tgaagcaaca gattaccctt     2160

ggaggcctgc tcttacccct tttgaatttc agaagctcct aaacaacttg acctctatca     2220

agatacgtgg gacatacagt gagagaagtg ctggatattt ggatgatgtc accctggcaa     2280

gtgctcgtcc tgggcctgga gtccctgcaa cttgggtgga gtcctgcacc tgtcctgtgg     2340

gatatggagg gcagttttgt gagatgtgcc tctcaggtta cagaagagaa actcctaatc     2400

ttggaccata cagtccatgt gtgctttgcg cctgcaatgg acacagcgag acctgtgatc     2460

ctgagacagg tgtttgtaac tgcagagaca atacggctgg cccgcactgt gagaagtgca     2520

gtgatgggta ctatggagat tcaactgcag gcacctcctc cgattgccaa ccctgtccgt     2580

gtcctggagg ttcaagttgt gctgttgttc ccaagacaaa ggaggtggtg tgcaccaact     2640

gtcctactgg caccactggt aagagatgtg agctctgtga tgatggctac tttggagacc     2700

ccctgggtag aaacggccct gtgagacttt gccgcctgtg ccagtgcagt gacaacatcg     2760

atcccaatgc agttggaaat tgcaatcgct tgacgggaga atgcctgaag tgcatctata     2820

acactgctgg cttctattgt gaccggtgca aagacggatt ttttggaaat cccctggctc     2880

ccaatccagc agacaaatgc aaagcctgca attgcaatct gtatgggacc atgaagcagc     2940

agagcagctg taaccccgtg acggggcagt gtgaatgttt gcctcacgtg actggccagg     3000

actgtggtgc ttgtgaccct ggattctaca atctgcagag tgggcaaggc tgtgagaggt     3060

gtgactgcca tgccttgggc tccaccaatg ggcagtgtga catccgcacc ggccagtgtg     3120

agtgccagcc cggcatcact ggtcagcact gtgagcgctg tgaggtcaac cactttgggt     3180

ttggacctga aggctgcaaa ccctgtgact gtcatcctga gggatctctt tcacttcagt     3240

gcaaagatga tggtcgctgt gaatgcagag aaggctttgt gggaaatcgc tgtgaccagt     3300

gtgaagaaaa ctatttctac aatcggtctt ggcctggctg ccaggaatgt ccagcttgtt     3360

accggctggt aaaggataag gttgctgatc atagagtgaa gctccaggaa ttagagagtc     3420

tcatagcaaa ccttggaact ggggatgaga tggtgacaga tcaagccttc gaggatagac     3480

taaaggaagc agagagggaa gttatggacc tccttcgtga ggcccaggat gtcaaagatg     3540

ttgaccagaa tttgatggat cgcctacaga gagtgaataa cactctgtcc agccaaatta     3600

gccgtttaca gaatatccgg aataccattg aagagactgg aaacttggct gaacaagcgc     3660

gtgcccatgt agagaacaca gagcggttga ttgaaatcgc atccagagaa cttgagaaag     3720

caaaagtcgc tgctgccaat gtgtcagtca ctcagccaga atctacaggg gacccaaaca     3780

acatgactct tttggcagaa gaggctcgaa agcttgctga acgtcataaa caggaagctg     3840

atgacattgt tcgagtggca aagacagcca atgatacgtc aactgaggca tacaacctgc     3900

ttctgaggac actggcagga gaaaatcaaa cagcatttga gattgaagag cttaatagga     3960

agtatgaaca agcgaagaac atctcacagg atctggaaaa acaagctgcc cgagtacatg     4020

aggaggccaa aagggccggt gacaaagctg tggagatcta tgccagcgtg gctcagctga     4080

gccctttgga ctctgagaca ctggagaatg aagcaaataa cataaagatg gaagctgaga     4140

atctggaaca actgattgac cagaaattaa aagattatga ggacctcaga gaagatatga     4200

gagggaagga acttgaagtc aagaaccttc tggagaaagg caagactgaa cagcagaccg     4260

cagaccaact cctagcccga gctgatgctg ccaaggccct cgctgaagaa gctgcaaaga     4320

agggacggga taccttacaa gaagctaatg acattctcaa caacctgaaa gattttgata     4380

ggcgtgtgaa cgataacaag acggccgcag aggaggcact aaggaagatt cctgccatca     4440

accagaccat cactgaagcc aatgaaaaga ccagagaagc ccagcaggcc ctgggcagtg     4500

ctgcggcgga tgccacagag gccaagaaca aggcccatga ggcggagagg atcgcgagcg     4560

ctgtccaaaa gaatgccacc agcaccaagg cagaagctga aagaactttt gcagaagtta     4620

cagatctgga taatgaggtg aacaatatgt tgaagcaact gcaggaagca gaaaaagagc     4680

taaagagaaa acaagatgac gctgaccagg acatgatgat ggcagggatg gcttcacagg     4740

ctgctcaaga agccgagatc aatgccagaa aagccaaaaa ctctgttact agcctcctca     4800

gcattattaa tgacctcttg gagcagctgg ggcagctgga tacagtggac ctgaataagc     4860

taaacgagat tgaaggcacc ctaaacaaag ccaaagatga aatgaaggtc agcgatcttg     4920

ataggaaagt gtctgacctg gagaatgaag ccaagaagca ggaggctgcc atcatggact     4980

ataaccgaga tatcgaggag atcatgaagg acattcgcaa tctggaggac atcaggaaga     5040

ccttaccatc tggctgcttc aacaccccgt ccattgaaaa gccctagtgt ctttagggct     5100

ggaaggcagc atccctctga caggggggca gttgtgaggc cacagagtgc cttgacacaa     5160

agattacatt tttcagaccc ccactcctct gctgctgtcc atgactgtcc ttttgaacca     5220

ggaaaagtca cagagtttaa agagaagcaa attaaacatc ctgaatcggg aacaaagggt     5280

tttatctaat aaagtgtctc ttccattcac gttgctacct tacccacact ttcccttctg     5340

atttgcgtga ggacgtggca tcctacgtta ctgtacagtg gcataagcac atcgtgtgag     5400

cccatgtatg ctggggtaga gcaagtagcc ctcccctgtc tcatcgatac cagcagaacc     5460

tcctcagtct cagtactctt gtttctatga aggaaaagtt tggctactaa cagtagcatt     5520

gtgatggcca gtatatccag tccatggata aagaaaatgc atctgcatct cctacccctc     5580

ttccttctaa gcaaaaggaa ataaacatcc tgtgccaaag gtattggtca tttagaatgt     5640

cggtagccat ccatcagtgc ttttagttat tatgagtgta ggacactgag ccatccgtgg     5700

gtcaggatgc aattatttat aaaagtctcc aggtgaacat ggctgaagat ttttctagta     5760

tattaataat tgactaggaa gatgaacttt ttttcagatc tttgggcagc tgataattta     5820

aatctggatg ggcagcttgc actcaccaat agaccaaaag acatcttttg atattcttat     5880

aaatggaact tacacagaag aaatagggat atgataacca ctaaaatttt gttttcaaaa     5940

tcaaactaat tcttacagct tttttattag ttagtcttgg aactagtgtt aagtatctgg     6000

cagagaacag ttaatcccta aggtcttgac aaaacagaag aaaaacaagc ctcctcgtcc     6060

tagtcttttc tagcaaaggg ataaaactta gatggcagct tgtactgtca gaatcccgtg     6120

tatccatttg ttcttctgtt ggagagatga gacatttgac ccttagctcc agttttcttc     6180

tgatgtttcc atcttccaga atccctcaaa aaacattgtt tgccaaatcc tggtggcaaa     6240

tacttgcact cagtatttca cacagctgcc aacgctatcg agttcctgca ctttgtgatt     6300

taaatccact ctaaaccttc cctctaagtg tagagggaag acccttacgt ggagtttcct     6360

agtgggcttc tcaacttttg atcctcagct ctgtggtttt aagaccacag tgtgacagtt     6420

ccctgccaca cacccccttc ctcctaccaa cccacctttg agattcatat atagccttta     6480

acactatgca actttgtact ttgcgtagca ggggcggggt ggggggaaag aaactattat     6540

ctgacacact ggtgctatta attatttcaa atttatattt ttgtgtgaat gttttgtgtt     6600

ttgtttatca tgattataga ataaggaatt tatgtaaata tacttagtcc tatttctaga     6660

atgacactct gttcactttg ctcaattttt cctcttcact ggcacaatgt atctgaatac     6720

ctccttccct cccttctaga attctttgga ttgtactcca aagaattgtg ccttgtgttt     6780

gcagcatctc cattctctaa aattaatata attgctttcc tccacaccca gccactgtaa     6840

agaggtaact tgggtcctct tccattgcag tcctgatgat cctaacctgc agcacggtgg     6900

ttttacaatg ttccagagca ggaacgccag gttgacaagc tatggtagga ttaggaaagt     6960

ttgctgaaga ggatctttga cgccacagtg ggactagcca ggaatgaggg agaaatgccc     7020

tttctggcaa ttgttggagc tggataggta agttttataa gggagtacat tttgactgag     7080

cacttagggc atcaggaaca gtgctactta ctgatgggta gactgggaga ggtggtgtaa     7140

cttagttctt gatgatccca cttcctgttt ccatctgctt gggatatacc agagtttacc     7200

acaagtgttt tgacgatata ctcctgagct ttcactctgc tgcttctccc aggcctcttc     7260

tactatggca ggagatgtgg cgtgctgttg caaagttttc acgtcattgt ttcctggcta     7320

gttcatttca ttaagtggct acatcctaac atatgcattt ggtcaaggtt gcagaagagg     7380

actgaagatt gactgccaag ctagtttggg tgaagttcac tccagcaagt ctcaggccac     7440

aatggggtgg tttggtttgg tttcctttta actttctttt tgttatttgc ttttctcctc     7500

cacctgtgtg gtatattttt taagcagaat tttatttttt aaaataaaag gttctttaca     7560

agatgatacc ttaattacac tcccgcaaca cagccattat tttattgtct agctccagtt     7620

atctgtattt tatgtaatgt aattgacagg atggctgctg cagaatgctg gttgacacag     7680

ggattattat actgctattt ttccctgaat ttttttcctt tgaattccaa ctgtggacct     7740

tttatatgtg ccttcacttt agctgtttgc cttaatctct acagccttgc tctccggggt     7800

ggttaataaa atgcaacact tggcattttt atgttttaag aaaaacagta ttttatttat     7860

aataaaatct gaatatttgt aacccttta                                       7889


<210>  28
<211>  1609
<212>  PRT
<213>  homo sapiens

<400>  28

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  29
<211>  3363
<212>  DNA
<213>  homo sapiens

<400>  29
gacatagctg ccctaaaagg aatgaggaag cgagagctct ccagtgtctg gctggctccg       60

tccgtgtgac agcccatgat gttctttccg gtctctgtaa tattctgaat ttccacctgc      120

ccgccccttc gcttataatg cagagcatgt gaagggagac cggctcggtc tctctctctc      180

ccagtggact agaaggagca gagagttatg ctgtttctcc cattctttac agctcaccgg      240

atgtaaaaga actctggcta gagaccctcc aaggacagag gcacagccac acgggagtga      300

aatccacccc tggacagtca gccgcaatac tgatgaagct gagaagcagc cacaatgctt      360

caaaaacact aaacgccaat aatatggaga cactaatcga atgtcaatca gagggtgata      420

tcaaggaaca tcccctgttg gcatcatgtg agagtgaaga cagtatttgc cagctcattg      480

aagttaagaa gagaaagaag gtgctgtcct ggccctttct catgagaagg ctctcccctg      540

catcagattt ttctggggct ttggagacag acttgaaagc atcgctattt gatcagccct      600

tgtcaattat ctgcggtgac agtgacacac tccccagacc catccaggac attctcacta      660

ttctatgcct taaaggccct tcaacggaag ggatattcag gagagcagcc aacgagaaag      720

cccgtaagga gctgaaggag gagctcaact ctggggatgc ggtggatctg gagaggctcc      780

ccgtgcacct cctcgctgtg gtctttaagg acttcctcag aagtatcccc cggaagctac      840

tttcaagcga cctctttgag gagtggatgg gtgctctgga gatgcaggac gaggaggaca      900

gaatcgaggc cctgaaacag gttgcagata agctcccccg gcccaacctc ctgctactca      960

agcacttggt ctatgtgctg cacctcatca gcaagaactc tgaggtgaac aggatggact     1020

ccagcaatct ggccatctgc attggaccca acatgctcac cctggagaat gaccagagcc     1080

tgtcatttga agcccagaag gacctgaaca acaaggtgaa gacactggtg gaattcctca     1140

ttgataactg ctttgaaata tttggggaga acattccagt gcattccagt atcacttctg     1200

atgactccct ggagcacact gacagttcag atgtgtcgac cctgcagaat gactcagcct     1260

acgacagcaa cgaccctgat gtggaatcca acagcagcag tggcatcagc tctcccagca     1320

ggcagcccca ggtgcccatg gccacagctg ctggcttgga tagcgcgggc ccacaggatg     1380

cccgagaggt cagcccagag cccattgtga gcaccgtggc caggctgaaa agctccctcg     1440

cacagcccga taggagatac tcagagccca gcatgccatc ctcccaggag tgcctcgaga     1500

gccgggtgac aaaccaaaca ctaacaaaga gtgaagggga cttccccgtg ccccgggtag     1560

gctctcgttt ggaaagtgag gaggctgaag acccatttcc agaggaggtc ttccctgcag     1620

tgcaaggcaa aaccaagagg ccggtggacc tgaagatcaa gaacttggcc ccgggttcgg     1680

tgctcccgcg ggcactggtt ctcaaagcct tctccagcag ctcgctggac gcgtcctctg     1740

acagctcgcc cgtggcttct ccttccagtc ccaaaagaaa tttcttcagc agacatcagt     1800

ctttcaccac aaagacagag aaaggcaagc ccagccgaga aattaaaaag cactccatgt     1860

ctttcacctt tgcccctcac aaaaaagtgc tgaccaaaaa cctcagcgcg ggctctggga     1920

aatcgcaaga ctttaccagg gaccacgtcc cgaggggtgt cagaaaggaa agccagcttg     1980

ccggccgaat cgtgcaggaa aatgggtgtg aaacccacaa ccaaacagcc cgcggcttct     2040

gcctgagacc ccacgccctc tcggtggatg atgtgttcca gggagctgac tgggagaggc     2100

ctggaagccc accctcttat gaagaggcca tgcagggccc ggcagccaga ctagtggcct     2160

ccgagagcca gaccgtgggg agcatgacgg tggggagcat gagggcgagg atgctggagg     2220

cgcactgcct cctaccccct cttccacctg ctcaccacgt agaggactca agacacaggg     2280

gcagcaaaga gccactccct ggccacggac tctctcccct gcctgagcga tggaaacaga     2340

gcagaactgt ccatgcttct ggggactctc tggggcacgt gtctggccca gggagacctg     2400

agctcctccc gctgaggacc gtctccgagt ccgtgcagag gaataagcgg gactgtctcg     2460

tgcgacgatg tagccagccg gtctttgagg ctgaccaatt ccaatatgcc aaagaatcgt     2520

atatttagga gggaggccat acgccatgcc atagcttgtg ctatctgtaa atatgagact     2580

tgtaaagaac tgcctgtaga ttgtttttaa aaggtcttga ataagctcct tgagaaagtt     2640

gtggaaagcc ctcctcagtg aggatagcta caccatggcc atggcgcatc agatagtctc     2700

tgtgtacctg gatttgtgca atatgtaaaa atgtatcaaa tgtattatag ataaggtgtt     2760

aggtgcaaag gatgtctaat aatccctgca cacgttttga acttgcagtg aagtacactg     2820

ctgttccttg cttcctgggg cacttttctc ttggttagtg tttaaaaatt atcttcgctt     2880

ttttaatgtg gcctcaaatg tcatgccaat tttcacatct tccacaaact ccatttaggg     2940

agaaatgttt aaatctctgg tataagttta ctccatacca gagtaaacta tatattactc     3000

tatataagca gtcttgcaat aactaatcac caccatagaa gaaagaaaca gactgcaagg     3060

aacagagttg agtgtctgga gtcatcaaag gcattaaaaa ctccagtaaa agctggggcc     3120

gtagcaaaaa tcatgaaaaa cacttcaacg tgtcctttca atcatccaat taaatgtggg     3180

tagattaatg aaaatgtatt acatcaatat taactcatct atagcacttt gagtatcttt     3240

gtagttcatg atatcctatc ctataatgtg gaggtaaatg attttatatg cattgggggt     3300

catatataaa acttcaatgt aatttcacta caataaattg ccttccttat ttgaaagtaa     3360

aaa                                                                   3363


<210>  30
<211>  731
<212>  PRT
<213>  homo sapiens

<400>  30

Met Lys Leu Arg Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn 
1               5                   10                  15      


Asn Met Glu Thr Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu 
            20                  25                  30          


His Pro Leu Leu Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu 
        35                  40                  45              


Ile Glu Val Lys Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met 
    50                  55                  60                  


Arg Arg Leu Ser Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp 
65                  70                  75                  80  


Leu Lys Ala Ser Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp 
                85                  90                  95      


Ser Asp Thr Leu Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys 
            100                 105                 110         


Leu Lys Gly Pro Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu 
        115                 120                 125             


Lys Ala Arg Lys Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val 
    130                 135                 140                 


Asp Leu Glu Arg Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp 
145                 150                 155                 160 


Phe Leu Arg Ser Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu 
                165                 170                 175     


Glu Trp Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu 
            180                 185                 190         


Ala Leu Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu 
        195                 200                 205             


Leu Lys His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu 
    210                 215                 220                 


Val Asn Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn 
225                 230                 235                 240 


Met Leu Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys 
                245                 250                 255     


Asp Leu Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn 
            260                 265                 270         


Cys Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr 
        275                 280                 285             


Ser Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu 
    290                 295                 300                 


Gln Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn 
305                 310                 315                 320 


Ser Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met 
                325                 330                 335     


Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu 
            340                 345                 350         


Val Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser 
        355                 360                 365             


Leu Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser 
    370                 375                 380                 


Gln Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser 
385                 390                 395                 400 


Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu 
                405                 410                 415     


Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly 
            420                 425                 430         


Lys Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly 
        435                 440                 445             


Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser 
    450                 455                 460                 


Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro 
465                 470                 475                 480 


Lys Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu 
                485                 490                 495     


Lys Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr 
            500                 505                 510         


Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser 
        515                 520                 525             


Gly Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg 
    530                 535                 540                 


Lys Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu 
545                 550                 555                 560 


Thr His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu 
                565                 570                 575     


Ser Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser 
            580                 585                 590         


Pro Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val 
        595                 600                 605             


Ala Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg 
    610                 615                 620                 


Ala Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala 
625                 630                 635                 640 


His His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro 
                645                 650                 655     


Gly His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr 
            660                 665                 670         


Val His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg 
        675                 680                 685             


Pro Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn 
    690                 695                 700                 


Lys Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala 
705                 710                 715                 720 


Asp Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile 
                725                 730     


<210>  31
<211>  1534
<212>  DNA
<213>  homo sapiens

<400>  31
tattgtcaga gtcctcttgt ttggccttct aggaaggctg tgggacccag ctttcttcaa       60

ccagtccagg tggaggcctc tgccttgaac gtttccaagt gaggtaaaac ccgcaggccc      120

agaggcctct ctacttcctg tgtggggttc agaaaccctc ctcccctccc agcctcaggt      180

gcctgcttca gaaaatgaag tagtaagtct gctggcctcc gccatcttag taaagtaaca      240

gtcccatgaa acaaagatgc agtcgggcac tcactggaga gttctgggcc tctgcctctt      300

atcagttggc gtttgggggc aagatggtaa tgaagaaatg ggtggtatta cacagacacc      360

atataaagtc tccatctctg gaaccacagt aatattgaca tgccctcagt atcctggatc      420

tgaaatacta tggcaacaca atgataaaaa cataggcggt gatgaggatg ataaaaacat      480

aggcagtgat gaggatcacc tgtcactgaa ggaattttca gaattggagc aaagtggtta      540

ttatgtctgc taccccagag gaagcaaacc agaagatgcg aacttttatc tctacctgag      600

ggcaagagtg tgtgagaact gcatggagat ggatgtgatg tcggtggcca caattgtcat      660

agtggacatc tgcatcactg ggggcttgct gctgctggtt tactactgga gcaagaatag      720

aaaggccaag gccaagcctg tgacacgagg agcgggtgct ggcggcaggc aaaggggaca      780

aaacaaggag aggccaccac ctgttcccaa cccagactat gagcccatcc ggaaaggcca      840

gcgggacctg tattctggcc tgaatcagag acgcatctga ccctctggag aacactgcct      900

cccgctggcc caggtctcct ctccagtccc cctgcgactc cctgtttcct gggctagtct      960

tggaccccac gagagagaat cgttcctcag cctcatggtg aactcgcgcc ctccagcctg     1020

atcccccgct ccctcctccc tgccttctct gctggtaccc agtcctaaaa tattgctgct     1080

tcctcttcct ttgaagcatc atcagtagtc acaccctcac agctggcctg ccctcttgcc     1140

aggatattta tttgtgctat tcactccctt ccctttggat gtaacttctc cgttcagttc     1200

cctccttttc ttgcatgtaa gttgtccccc atcccaaagt attccatcta cttttctatc     1260

gccgtcccct tttgcagccc tctctgggga tggactgggt aaatgttgac agaggccctg     1320

ccccgttcac agatcctggc cctgagccag ccctgtgctc ctccctcccc caacactccc     1380

taccaacccc ctaatcccct actccctcca ccccccctcc actgtaggcc actggatggt     1440

catttgcatc tccgtaaatg tgctctgctc ctcagctgag agagaaaaaa ataaactgta     1500

tttggctgca agaaaaaaaa aaaaaaaaaa aaaa                                 1534


<210>  32
<211>  207
<212>  PRT
<213>  homo sapiens

<400>  32

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  33
<211>  2993
<212>  DNA
<213>  homo sapiens

<400>  33
cgctggggcg ctttccgagg aaattcggga ctcgagtttc ccggggaaga ggcgcggcct       60

gagcccggcg agggtgggga gggcaggcgc aggtggaccc cggcgccccc cgagccccgc      120

tgtgaccttg gccgcggggg aggggctggg ccgctgcggg gcagtcgcgg ccgccagagg      180

gggcagcgga gaagaacttg cccaacttgg cggcgcgggc tggggcggct ctgcgcctcc      240

gcgcccgcct ccccggcctc cgccttctcc cctcccgcga gcctcctccc ctcccgcgag      300

cctcctcccc tgggccctcc tcccgtcctc cccgccgccg ccggtcccgg tgcgcgccca      360

tccctgcccg cagccccgcg cgccggccga gtcgctgagc cgcggctgcc ggacgggacg      420

ggaccggcta ggctgggcgc gccccccggg ccccgccgtg ggcatgggcg cactggcccg      480

ggcgctgctg ctgcctctgc tggcccagtg gctcctgcgc gccgccccgg agctggcccc      540

cgcgcccttc acgctgcccc tccgggtggc cgcggccacg aaccgcgtag ttgcgcccac      600

cccgggaccc gggacccctg ccgagcgcca cgccgacggc ttggcgctcg ccctggagcc      660

tgccctggcg tcccccgcgg gcgccgccaa cttcttggcc atggtagaca acctgcaggg      720

ggactctggc cgcggctact acctggagat gctgatcggg acccccccgc agaagctaca      780

gattctcgtt gacactggaa gcagtaactt tgccgtggca ggaaccccgc actcctacat      840

agacacgtac tttgacacag agaggtctag cacataccgc tccaagggct ttgacgtcac      900

agtgaagtac acacaaggaa gctggacggg cttcgttggg gaagacctcg tcaccatccc      960

caaaggcttc aatacttctt ttcttgtcaa cattgccact atttttgaat cagagaattt     1020

ctttttgcct gggattaaat ggaatggaat acttggccta gcttatgcca cacttgccaa     1080

gccatcaagt tctctggaga ccttcttcga ctccctggtg acacaagcaa acatccccaa     1140

cgttttctcc atgcagatgt gtggagccgg cttgcccgtt gctggatctg ggaccaacgg     1200

aggtagtctt gtcttgggtg gaattgaacc aagtttgtat aaaggagaca tctggtatac     1260

ccctattaag gaagagtggt actaccagat agaaattctg aaattggaaa ttggaggcca     1320

aagccttaat ctggactgca gagagtataa cgcagacaag gccatcgtgg acagtggcac     1380

cacgctgctg cgcctgcccc agaaggtgtt tgatgcggtg gtggaagctg tggcccgcgc     1440

atctctgatt ccagaattct ctgatggttt ctggactggg tcccagctgg cgtgctggac     1500

gaattcggaa acaccttggt cttacttccc taaaatctcc atctacctga gagacgagaa     1560

ctccagcagg tcattccgta tcacaatcct gcctcagctt tacattcagc ccatgatggg     1620

ggccggcctg aattatgaat gttaccgatt cggcatttcc ccatccacaa atgcgctggt     1680

gatcggtgcc acggtgatgg agggcttcta cgtcatcttc gacagagccc agaagagggt     1740

gggcttcgca gcgagcccct gtgcagaaat tgcaggtgct gcagtgtctg aaatttccgg     1800

gcctttctca acagaggatg tagccagcaa ctgtgtcccc gctcagtctt tgagcgagcc     1860

cattttgtgg attgtgtcct atgcgctcat gagcgtctgt ggagccatcc tccttgtctt     1920

aatcgtcctg ctgctgctgc cgttccggtg tcagcgtcgc ccccgtgacc ctgaggtcgt     1980

caatgatgag tcctctctgg tcagacatcg ctggaaatga atagccaggc ctgacctcaa     2040

gcaaccatga actcagctat taagaaaatc acatttccag ggcagcagcc gggatcgatg     2100

gtggcgcttt ctcctgtgcc cacccgtctt caatctctgt tctgctccca gatgccttct     2160

agattcactg tcttttgatt cttgattttc aagctttcaa atcctcccta cttccaagaa     2220

aaataattaa aaaaaaaact tcattctaaa ccaaaacaga gtggattggg ctgcaggctc     2280

tatggggttc gttatgccaa agtgtctaca tgtgccacca acataaaaca aaaccaagcc     2340

ttggctcgtt ctcttctctc ttcaatctct ggaaaaataa gtacatatag ttgataaccc     2400

ctcttagctt acaggaagct ttttgtatta attgcctttg aggttatttt ccgccagacc     2460

tcaacctggg tcaaagtggt acaggaaggc ttgcagtatg atggcaggag aatcagcctg     2520

gggcctgggg atgtaaccaa gctgtaccct tgagacctgg aaccagagcc acaggcccct     2580

tttgtgggtt tctctgtgct ctgaatggga gccagaattc actaggaggt catcaaccga     2640

tggtcctcac aagcctcttc tgaagatgga aggccttttg cccgttgagg tagaggggaa     2700

ggaaatctcc tcttttgtac ccaatactta tgttgtattg ttggtgcgaa agtaaaaaca     2760

ctacctcttt tgagactttg cccagggtcc tgtgcctgga tgggggtgca ggcagccttg     2820

accacggctg ttcccctcac ccaaaagaat tatcatccca acagccaaga cccaacaggt     2880

gctgaactgt gcatcaacca ggaagagttc tatccccaag ctggccacta tcacatatgc     2940

ttactcttgc ttaaaattaa taaatcatgt tttgatgaga aaaaactatt cta            2993


<210>  34
<211>  518
<212>  PRT
<213>  homo sapiens

<400>  34

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln Pro Met 
    370                 375                 380                 


Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro 
385                 390                 395                 400 


Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr 
                405                 410                 415     


Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro 
            420                 425                 430         


Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe 
        435                 440                 445             


Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser 
    450                 455                 460                 


Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly 
465                 470                 475                 480 


Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys 
                485                 490                 495     


Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu 
            500                 505                 510         


Val Arg His Arg Trp Lys 
        515             


<210>  35
<211>  7580
<212>  DNA
<213>  homo sapiens

<400>  35
ggcgaggatg gggagcaatg caaagctctg ctcgcccccc atctcacccc ccaagcggat       60

actggtcttc tcgtcggatt gcccatgcac ttgttgcaga aacagccaag gccctggctg      120

tggagaatgc tgaaggaaga agacgcagaa gcaggacgac cctgaaagat tcagcctctt      180

catcctcaaa caggaccagg cctcctcttc ccacctgtcc agcagcatga aagcagcatg      240

attggccgac cgcaggagaa gcccccagaa ccaggccccc aactcagcca tctgcggagg      300

tcaaggtgtg agcgacgtct cctcaccaca gtgctgtgtg gtctatacct cagccaggga      360

gaggatgtga aaccccccgc cctgcacatg agtggtacag gccaacagga acacctggct      420

ccagccacgt tcacagacat gtcagccgtg gagtagtgct gacacttttc tctcagcttc      480

tcagggtttc agtccttttg ggtttgtttt atttaccttt tttatggttt tgtggctgga      540

cgttcacaac caaggcagac agcatgggtg accagcaact gtacaagacc aaccatgtgg      600

cccatggtag tgagaacctt ttctaccaac agccaccact tggcgtccac agcgggctga      660

accacaacta tgggaatgca gttacagggg gcggaatgga tgcccctcag gcctcgccaa      720

tctcccccca cttccctcaa gatacacggg atggtctggg cttgcctgtt ggctccaaaa      780

accttggcca aatggatacc tcgaggcagg gagggtgggg aagtcatgca gggcctggaa      840

accatgtcca gctacgtgga aacctggcca actcaaacat gatgtggggg gcaccagccc      900

aggctgagcc cactgatggc taccaataca cctactccca ggccagcgag atccggaccc      960

agaagcttac cagcggtgtc ttacacaagc tggactcttt cacccaggtg tttgccaacc     1020

aaaacctgcg aattcaggtc aacaatatgg cccaggtgct gcacactcag tcagcagtga     1080

tggatggagc ccctgacagt gctctccgcc agctgctgtc tcagaagccc atggagcccc     1140

cagcaccggc tatcccttcc cgctaccagc aggtgcccca gcagcctcac cctggtttca     1200

ctggtgggct gtccaaacca gctcttcagg tcgggcagca ccctacccaa gggcacctgt     1260

attatgacta ccagcagcct ctggctcagg tgccagtgca gggaggacag ccactgcagg     1320

ccccacagat gctgtcacag cacatgcaac agatgcagca gcaccagtat tacccaccgc     1380

agcaacagca gcaagccggg caacagcgta tctccatgca agaaatacag acgcagccgc     1440

aacaaattcg cccatcacag ccacagccgc cgccacagca gcagcagccg cagcagctac     1500

agctgcagca gcggcagggt tcaatgcaga tacctcagta ttatcagccc caacccatga     1560

tgcagcactt gcaagagcag cagcagcaac agatgcacct gcagcctcct tcttatcaca     1620

gggaccctca ccagtatacc ccagagcagg cacacactgt ccagctgatt cccctgggct     1680

ccatgtccca gtactactac caggagcccc agcagcccta cagccacccc ctctaccagc     1740

agagccacct gtcccagcac cagcagcgtg aggacagtca gctgaagacc tactctagtg     1800

acagacaggc ccaggccatg ctgagctccc atggggacct ggggcctcct gacacaggaa     1860

tgggagaccc agcgagctca gatctgaccc gggtcagcag caccctcccc catcgccccc     1920

tcctatcccc cagtgggatc cacctcaaca acatggggcc tcagcatcag cagctgtctc     1980

ccagtgccat gtggccccag atgcacctac ctgatgggag agcccagcca gggtcccctg     2040

agtcaagtgg ccaacccaaa ggagcgtttg gggagcagtt tgatgccaag aacaagctga     2100

catgctccat ctgcctgaag gagttcaaga acctgcctgc cctgaatggc cacatgcggt     2160

cccacggggg aatgagggcc tcccccaacc tcaaacagga ggaaggagag aaggtcctgc     2220

cgcctcagcc ccagccacca ctgccgcctc cgcctccgcc tccgccgcca ccacagctcc     2280

ctcccgaggc agaaagcctc acgcctatgg tcatgcccgt gtctgtccct gtcaagcttc     2340

tcccgcccaa gcccagctct caggggttca ccaacagcac cgttgccgcc ccctccgcca     2400

gagacaagcc agccagctcg atgtcggacg acgagatgcc tgtgctcgaa atccccagga     2460

agcatcagcc gagtgtgccc aaagccgagg agcccctcaa gaccgtgcag gagaagaaaa     2520

agttccggca ccggccggaa cctctcttca tcccgccgcc gccctcctac aacccgaacc     2580

ccgctgcctc ctactcgggc gccaccctgt accagagcca gctgcgctcc ccgcgcgtcc     2640

tcggggacca cctgctcctg gaccccaccc acgagctgcc cccttacacg cccccaccca     2700

tgctgagccc ggtgcgccag ggctcggggc tcttcagcaa tgtcctcatc tccggccacg     2760

gccctggcgc ccacccgcag ctgcccctga cgcccctgac gcccacacca cgggtgctgc     2820

tgtgtcgctc caacagcatc gatggcagca acgtgacggt caccccaggg cctggagagc     2880

agactgtaga tgttgaacca cgcatcaaca ttggcttgag attccaagca gaaatccctg     2940

aactccaaga tatctctgcc ctggcccagg acacacacaa ggccacactg gtatggaagc     3000

cctggccaga actagaaaac catgacctcc agcaaagagt ggagaatctt ctgaatttgt     3060

gctgttccag tgcattgcca ggtggaggga ccaattctga atttgctttg cactctctgt     3120

ttgaggccaa aggtgatgtg atggttgctc tggaaatgct gctactgcgg aagcctgtca     3180

ggttaaaatg tcatccttta gcaaattacc actatgccgg ttcggacaag tggacctccc     3240

tagaaagaaa actgtttaac aaagcactag ccacttacag caaagacttt atttttgtac     3300

agaagatggt gaagtccaag acggtggctc agtgcgtgga gtactactac acgtggaaaa     3360

agatcatgcg gctggggcgg aaacaccgga cacgcctggc agaaatcatc gacgattgtg     3420

tgacaagtga agaagaagaa gagttagagg aggaggagga ggaggacccg gaagaagata     3480

ggaaatccac aaaagaagaa gagagtgagg tgccgaagtc cccggagcca ccacccgtcc     3540

ccgtcctggc tcccacggag gggccgcccc tgcaggccct gggccagccc tcaggctcct     3600

tcatctgtga aatgcccaac tgtggggctg tgttcagctc ccgacaggca ctgaatggcc     3660

atgcccgcat ccacgggggc accaaccagg tgaccaaggc ccgaggtgcc atcccctctg     3720

ggaagcagaa gcctggtggc acccagagtg ggtactgttc ggtaaagagc tcaccctctc     3780

acagcaccac cagcggcgag acagacccca ccaccatctt cccctgcaag gagtgtggca     3840

aagtcttctt caagatcaaa agccgaaatg cacacatgaa aactcacagg cagcaggagg     3900

aacaacagag gcaaaaggct cagaaggcgg cttttgcagc tgagatggca gccacgattg     3960

agaggactac ggggcccgtg ggggcgccgg ggctgctgcc cctggaccag ctgagtctga     4020

tcaaacccat caaggatgtg gacatcctcg acgacgacgt cgtccagcag ttgggaggtg     4080

tcatggaaga ggctgaagtt gtggacaccg atcttctctt ggatgatcaa gattcagtct     4140

tgcttcaggg tgacgcagaa ctataaagcc ctgtgtgtca cttagagaca gtgaaaaccc     4200

acggcctcca tcttcattaa tcaggaaacc tggactgcct gcttgttttg taaccctttt     4260

aaactacctg ttttaaaagt ggtcatttta ttcaggttta gaaaaaaaaa tcctatttct     4320

tttcctttta tttaaaaaaa tttgtttttg tggggggttg ggggaataaa taattggcac     4380

aactatcttt aagaggtgtt tcatctgggc taccttctca tgaaatcatt cccagtaggg     4440

actgaagctg accttcatgt tccattgcat tcagatgtca accatcccgg ttgcctttta     4500

tcccaaagct tgctgtgagt gtgtgtgtgt gagacgcagg cgaccctctt agtactgggg     4560

tcttggggcc aacttttccc atcaagcgtt actttgattc tgttctgacc tcattccata     4620

gtttgcagtg agcatggcat ctttgcctgg agatactatg ctaggggcag ctttccaggg     4680

gcaaagcaag ccctcgtgtt acacggctct cctccagctc acacgacatg tgaggagatg     4740

accaaatgtg aaaacaggtt tcccctgtgt tgcccgtcat cctttggccc gttcacagga     4800

atggagtact gtataatttt aggctttcat tcccagcagt gtttactgag gacctggttt     4860

tctagaacag gtgtgtcctg tcctcttcca tgttccctgg gggctggtca gctccaagtt     4920

gtgggtggca gagctgtgtt tcagcatgaa ctgactagag acccatctgg aggcaaatat     4980

taagttgcca ggactgcttt cacttcaggg tgattgaagg acacatattg aagtacctag     5040

aatgccagaa agtgttctat tgcccaaaaa acaaatcaga aaagcctatt cttttttgca     5100

acgctgttaa tgattagtgg agttctgaaa ttactttgtg ccacttggaa gtactgtgaa     5160

accgcattca ctgggatttt gctgtaattc acatccgctg gactgaagtt taccttgatg     5220

ttagctataa gaaatagttt tctaacacat acgatagcaa atacaagaca aatagcattg     5280

aaggccaaca aaaatggctt cagatacacc ttagctataa tgtttgcatt caaacaatga     5340

atgtattcat cacaagtcac ttaccaaagc acttctagac ttctccaacc tccatgactt     5400

tgctctgctt cctcctgtcc ctgtcagcag ggttgctgtt tgtacttgaa ggtaataaac     5460

ctgtaatcct tcaaaaatgc catttagccc caggcttctg agctgagtca gactgaccca     5520

tcccaccgtt agggcaaaag tcaggctggg acacagcgcc agtacagaga ggatcctgct     5580

tcatgcaact ccccttttgg agttaatgca gcgtgatttc ctgggccggt gttttcaggc     5640

atcgcccacc ccaggtatgc tggttcccag ctccacgtag gtgtgcctat cacgctgggc     5700

cactttgctg acaacattca tagcttgaca tgagagagaa tatcagcaga agcatgagag     5760

taggacctga cgtctttgac tctgcaaaag catttagcac acactcatgg gggggaactg     5820

gctgtgagcc acagcagccc cacacagaca gtggtctctg aacttcagga aagccatgga     5880

cagaaaaaaa aataaaattc ttttccatca ttctattttc aaagaggtct tggcgttttc     5940

ctacatcttt tgtttagagg gggaaaaaag tttcatttgc tgccatttca gaaaggttat     6000

gctatcctgt tttatccaag cagttgtgag tcaggaactg cctgggcagt gtgcatcaac     6060

tttgtggccg aaccattaca gctgtcatat ccttggctga tcgtctctcc cagggactac     6120

tgccctccac ttagtgtctg agggtaagcc tagaagggtg ctgctattgg gtctatggaa     6180

gcttatctat caaaggagca aacatccaga aaagtgttta taaagcaaat gtattgcctc     6240

tgtttagaga tttgcccagc tgttccagtt ttaaacatta aaaaataaac tcagttgcca     6300

tggcaaaaat agaatgcaca gcttacttat aattttccat gcagtatagc ataaggattt     6360

ttgacttgaa acaaccaaag aactcctcct taacgagaca gttcaaattc ctgaattagt     6420

atttcttgac tatcaactta aagaatggac ttcctagtac aatgttgcac ttattttttt     6480

ttctgaaata attctgcctg catgtatgtg ttgtgtttta gcttctcccc ttaccccacc     6540

ccaaagatct tttcttccta atggttaatg tctcaactcg gttactgttt actatcagat     6600

ggtttttcat tagtgaattt agacctcttt gagaaagctt gtatataaaa agttaacaga     6660

tatattttat ggaaaaaccc atcttatttt caaatatatt taactgctgt tatattttat     6720

tagaggaagg ttgtaaatat tttctaggag ttctattgta aagaaaagta tttttgaaaa     6780

aaattaatgt aataaaaagg aaaacatttt taaatagtgg ttgtgattgc ttcctgttct     6840

ggcttcgtta tgttctattc tcagcagatg aattgcatgc cttccatatc aggatgtaat     6900

ttattcaggt ttgcactatt ataagttgac atcataatat ctagtgtgct taactgtatt     6960

ttcccggaat gcaagtccct tggtccatat taaagcacta tgtatagcat attcataatt     7020

tttcttttgt aacgtgtgta tttttaataa ggattttatg taacattttg gcaacaagag     7080

gaccgtattt tctagtgaat tttataataa cattttgcta aaaatgtttc ttcctaggtc     7140

agtttttgtt aaggtgaacc aaaagtctta ttttaccagg ggtttaaaaa aagtttgaag     7200

cttgaaagca aagttatatt taaacatcat atgtaacaaa taaataaaga tgttttatag     7260

acttgtccta aaaaggtgca ttccttaaaa aaaaaaaaaa gaaaaaaaaa ggaaactggg     7320

gcattctagg ttgtttcccc tccaagtgat aagctttttt tttttcttaa ttatcacaat     7380

gcttcttcaa aaagggaacc agggaaattt tatttaacac attctaatca ttagcctctc     7440

agaaagttat tacagttcct atagatgggc attcatcaaa tggagatgta accaaacaga     7500

cactgtcata tttatttgtg aaaacctgat tcaatattgc atcagctgct ctgaaaataa     7560

aatattaatc ttttgcgttt                                                 7580


<210>  36
<211>  1200
<212>  PRT
<213>  homo sapiens

<400>  36

Met Gly Asp Gln Gln Leu Tyr Lys Thr Asn His Val Ala His Gly Ser 
1               5                   10                  15      


Glu Asn Leu Phe Tyr Gln Gln Pro Pro Leu Gly Val His Ser Gly Leu 
            20                  25                  30          


Asn His Asn Tyr Gly Asn Ala Val Thr Gly Gly Gly Met Asp Ala Pro 
        35                  40                  45              


Gln Ala Ser Pro Ile Ser Pro His Phe Pro Gln Asp Thr Arg Asp Gly 
    50                  55                  60                  


Leu Gly Leu Pro Val Gly Ser Lys Asn Leu Gly Gln Met Asp Thr Ser 
65                  70                  75                  80  


Arg Gln Gly Gly Trp Gly Ser His Ala Gly Pro Gly Asn His Val Gln 
                85                  90                  95      


Leu Arg Gly Asn Leu Ala Asn Ser Asn Met Met Trp Gly Ala Pro Ala 
            100                 105                 110         


Gln Ala Glu Pro Thr Asp Gly Tyr Gln Tyr Thr Tyr Ser Gln Ala Ser 
        115                 120                 125             


Glu Ile Arg Thr Gln Lys Leu Thr Ser Gly Val Leu His Lys Leu Asp 
    130                 135                 140                 


Ser Phe Thr Gln Val Phe Ala Asn Gln Asn Leu Arg Ile Gln Val Asn 
145                 150                 155                 160 


Asn Met Ala Gln Val Leu His Thr Gln Ser Ala Val Met Asp Gly Ala 
                165                 170                 175     


Pro Asp Ser Ala Leu Arg Gln Leu Leu Ser Gln Lys Pro Met Glu Pro 
            180                 185                 190         


Pro Ala Pro Ala Ile Pro Ser Arg Tyr Gln Gln Val Pro Gln Gln Pro 
        195                 200                 205             


His Pro Gly Phe Thr Gly Gly Leu Ser Lys Pro Ala Leu Gln Val Gly 
    210                 215                 220                 


Gln His Pro Thr Gln Gly His Leu Tyr Tyr Asp Tyr Gln Gln Pro Leu 
225                 230                 235                 240 


Ala Gln Val Pro Val Gln Gly Gly Gln Pro Leu Gln Ala Pro Gln Met 
                245                 250                 255     


Leu Ser Gln His Met Gln Gln Met Gln Gln His Gln Tyr Tyr Pro Pro 
            260                 265                 270         


Gln Gln Gln Gln Gln Ala Gly Gln Gln Arg Ile Ser Met Gln Glu Ile 
        275                 280                 285             


Gln Thr Gln Pro Gln Gln Ile Arg Pro Ser Gln Pro Gln Pro Pro Pro 
    290                 295                 300                 


Gln Gln Gln Gln Pro Gln Gln Leu Gln Leu Gln Gln Arg Gln Gly Ser 
305                 310                 315                 320 


Met Gln Ile Pro Gln Tyr Tyr Gln Pro Gln Pro Met Met Gln His Leu 
                325                 330                 335     


Gln Glu Gln Gln Gln Gln Gln Met His Leu Gln Pro Pro Ser Tyr His 
            340                 345                 350         


Arg Asp Pro His Gln Tyr Thr Pro Glu Gln Ala His Thr Val Gln Leu 
        355                 360                 365             


Ile Pro Leu Gly Ser Met Ser Gln Tyr Tyr Tyr Gln Glu Pro Gln Gln 
    370                 375                 380                 


Pro Tyr Ser His Pro Leu Tyr Gln Gln Ser His Leu Ser Gln His Gln 
385                 390                 395                 400 


Gln Arg Glu Asp Ser Gln Leu Lys Thr Tyr Ser Ser Asp Arg Gln Ala 
                405                 410                 415     


Gln Ala Met Leu Ser Ser His Gly Asp Leu Gly Pro Pro Asp Thr Gly 
            420                 425                 430         


Met Gly Asp Pro Ala Ser Ser Asp Leu Thr Arg Val Ser Ser Thr Leu 
        435                 440                 445             


Pro His Arg Pro Leu Leu Ser Pro Ser Gly Ile His Leu Asn Asn Met 
    450                 455                 460                 


Gly Pro Gln His Gln Gln Leu Ser Pro Ser Ala Met Trp Pro Gln Met 
465                 470                 475                 480 


His Leu Pro Asp Gly Arg Ala Gln Pro Gly Ser Pro Glu Ser Ser Gly 
                485                 490                 495     


Gln Pro Lys Gly Ala Phe Gly Glu Gln Phe Asp Ala Lys Asn Lys Leu 
            500                 505                 510         


Thr Cys Ser Ile Cys Leu Lys Glu Phe Lys Asn Leu Pro Ala Leu Asn 
        515                 520                 525             


Gly His Met Arg Ser His Gly Gly Met Arg Ala Ser Pro Asn Leu Lys 
    530                 535                 540                 


Gln Glu Glu Gly Glu Lys Val Leu Pro Pro Gln Pro Gln Pro Pro Leu 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Pro Glu Ala 
                565                 570                 575     


Glu Ser Leu Thr Pro Met Val Met Pro Val Ser Val Pro Val Lys Leu 
            580                 585                 590         


Leu Pro Pro Lys Pro Ser Ser Gln Gly Phe Thr Asn Ser Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Ala Arg Asp Lys Pro Ala Ser Ser Met Ser Asp Asp Glu 
    610                 615                 620                 


Met Pro Val Leu Glu Ile Pro Arg Lys His Gln Pro Ser Val Pro Lys 
625                 630                 635                 640 


Ala Glu Glu Pro Leu Lys Thr Val Gln Glu Lys Lys Lys Phe Arg His 
                645                 650                 655     


Arg Pro Glu Pro Leu Phe Ile Pro Pro Pro Pro Ser Tyr Asn Pro Asn 
            660                 665                 670         


Pro Ala Ala Ser Tyr Ser Gly Ala Thr Leu Tyr Gln Ser Gln Leu Arg 
        675                 680                 685             


Ser Pro Arg Val Leu Gly Asp His Leu Leu Leu Asp Pro Thr His Glu 
    690                 695                 700                 


Leu Pro Pro Tyr Thr Pro Pro Pro Met Leu Ser Pro Val Arg Gln Gly 
705                 710                 715                 720 


Ser Gly Leu Phe Ser Asn Val Leu Ile Ser Gly His Gly Pro Gly Ala 
                725                 730                 735     


His Pro Gln Leu Pro Leu Thr Pro Leu Thr Pro Thr Pro Arg Val Leu 
            740                 745                 750         


Leu Cys Arg Ser Asn Ser Ile Asp Gly Ser Asn Val Thr Val Thr Pro 
        755                 760                 765             


Gly Pro Gly Glu Gln Thr Val Asp Val Glu Pro Arg Ile Asn Ile Gly 
    770                 775                 780                 


Leu Arg Phe Gln Ala Glu Ile Pro Glu Leu Gln Asp Ile Ser Ala Leu 
785                 790                 795                 800 


Ala Gln Asp Thr His Lys Ala Thr Leu Val Trp Lys Pro Trp Pro Glu 
                805                 810                 815     


Leu Glu Asn His Asp Leu Gln Gln Arg Val Glu Asn Leu Leu Asn Leu 
            820                 825                 830         


Cys Cys Ser Ser Ala Leu Pro Gly Gly Gly Thr Asn Ser Glu Phe Ala 
        835                 840                 845             


Leu His Ser Leu Phe Glu Ala Lys Gly Asp Val Met Val Ala Leu Glu 
    850                 855                 860                 


Met Leu Leu Leu Arg Lys Pro Val Arg Leu Lys Cys His Pro Leu Ala 
865                 870                 875                 880 


Asn Tyr His Tyr Ala Gly Ser Asp Lys Trp Thr Ser Leu Glu Arg Lys 
                885                 890                 895     


Leu Phe Asn Lys Ala Leu Ala Thr Tyr Ser Lys Asp Phe Ile Phe Val 
            900                 905                 910         


Gln Lys Met Val Lys Ser Lys Thr Val Ala Gln Cys Val Glu Tyr Tyr 
        915                 920                 925             


Tyr Thr Trp Lys Lys Ile Met Arg Leu Gly Arg Lys His Arg Thr Arg 
    930                 935                 940                 


Leu Ala Glu Ile Ile Asp Asp Cys Val Thr Ser Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Leu Glu Glu Glu Glu Glu Glu Asp Pro Glu Glu Asp Arg Lys Ser Thr 
                965                 970                 975     


Lys Glu Glu Glu Ser Glu Val Pro Lys Ser Pro Glu Pro Pro Pro Val 
            980                 985                 990         


Pro Val Leu Ala Pro Thr Glu Gly  Pro Pro Leu Gln Ala  Leu Gly Gln 
        995                 1000                 1005             


Pro Ser  Gly Ser Phe Ile Cys  Glu Met Pro Asn Cys  Gly Ala Val 
    1010                 1015                 1020             


Phe Ser  Ser Arg Gln Ala Leu  Asn Gly His Ala Arg  Ile His Gly 
    1025                 1030                 1035             


Gly Thr  Asn Gln Val Thr Lys  Ala Arg Gly Ala Ile  Pro Ser Gly 
    1040                 1045                 1050             


Lys Gln  Lys Pro Gly Gly Thr  Gln Ser Gly Tyr Cys  Ser Val Lys 
    1055                 1060                 1065             


Ser Ser  Pro Ser His Ser Thr  Thr Ser Gly Glu Thr  Asp Pro Thr 
    1070                 1075                 1080             


Thr Ile  Phe Pro Cys Lys Glu  Cys Gly Lys Val Phe  Phe Lys Ile 
    1085                 1090                 1095             


Lys Ser  Arg Asn Ala His Met  Lys Thr His Arg Gln  Gln Glu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Gln Lys Ala Gln  Lys Ala Ala Phe Ala  Ala Glu Met 
    1115                 1120                 1125             


Ala Ala  Thr Ile Glu Arg Thr  Thr Gly Pro Val Gly  Ala Pro Gly 
    1130                 1135                 1140             


Leu Leu  Pro Leu Asp Gln Leu  Ser Leu Ile Lys Pro  Ile Lys Asp 
    1145                 1150                 1155             


Val Asp  Ile Leu Asp Asp Asp  Val Val Gln Gln Leu  Gly Gly Val 
    1160                 1165                 1170             


Met Glu  Glu Ala Glu Val Val  Asp Thr Asp Leu Leu  Leu Asp Asp 
    1175                 1180                 1185             


Gln Asp  Ser Val Leu Leu Gln  Gly Asp Ala Glu Leu  
    1190                 1195                 1200 


<210>  37
<211>  1237
<212>  DNA
<213>  homo sapiens

<400>  37
gctgcagagg attcctgcag aggatcaaga cagcacgtgg acctcgcaca gcctctccca       60

caggtaccat gaaggtctcc gcggcagccc tcgctgtcat cctcattgct actgccctct      120

gcgctcctgc atctgcctcc ccatattcct cggacaccac accctgctgc tttgcctaca      180

ttgcccgccc actgccccgt gcccacatca aggagtattt ctacaccagt ggcaagtgct      240

ccaacccagc agtcgtcttt gtcacccgaa agaaccgcca agtgtgtgcc aacccagaga      300

agaaatgggt tcgggagtac atcaactctt tggagatgag ctaggatgga gagtccttga      360

acctgaactt acacaaattt gcctgtttct gcttgctctt gtcctagctt gggaggcttc      420

ccctcactat cctaccccac ccgctccttg aagggcccag attctaccac acagcagcag      480

ttacaaaaac cttccccagg ctggacgtgg tggctcacgc ctgtaatccc agcactttgg      540

gaggccaagg tgggtggatc acttgaggtc aggagttcga gaccagcctg gccaacatga      600

tgaaacccca tctctactaa aaatacaaaa aattagccgg gcgtggtagc gggcgcctgt      660

agtcccagct actcgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt      720

gcagtgagcc gagatcgcgc cactgcactc cagcctgggc gacagagcga gactccgtct      780

caaaaaaaaa aaaaaaaaaa aaaatacaaa aattagccgg gcgtggtggc ccacgcctgt      840

aatcccagct actcgggagg ctaaggcagg aaaattgttt gaacccagga ggtggaggct      900

gcagtgagct gagattgtgc cacttcactc cagcctgggt gacaaagtga gactccgtca      960

caacaacaac aacaaaaagc ttccccaact aaagcctaga agagcttctg aggcgctgct     1020

ttgtcaaaag gaagtctcta ggttctgagc tctggctttg ccttggcttt gccagggctc     1080

tgtgaccagg aaggaagtca gcatgcctct agaggcaagg aggggaggaa cactgcactc     1140

ttaagcttcc gccgtctcaa cccctcacag gagcttactg gcaaacatga aaaatcggct     1200

taccattaaa gttctcaatg caaccataaa aaaaaaa                              1237


<210>  38
<211>  91
<212>  PRT
<213>  homo sapiens

<400>  38

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  39
<211>  2747
<212>  DNA
<213>  homo sapiens

<400>  39
tgctctgtgc tgggatcatg gaacttgcac tgctgtgtgg gctggtggtg atggctggtg       60

tgattccaat ccagggcggg atcctgaacc tgaacaagat ggtcaagcaa gtgactggga      120

aaatgcccat cctctcctac tggccctacg gctgtcactg cggactaggt ggcagaggcc      180

aacccaaaga tgccacggac tggtgctgcc agacccatga ctgctgctat gaccacctga      240

agacccaggg gtgcagcatc tacaaggact attacagata caacttttcc caggggaaca      300

tccactgctc tgacaaggga agctggtgtg agcagcagct gtgtgcctgt gacaaggagg      360

tggccttctg cctgaagcgc aacctggaca cctaccagaa gcgactgcgt ttctactggc      420

ggccccactg ccgggggcag acccctgggt gctagaagcc cacaccctct accctgttcc      480

tcagcatgga gctctggcat ccccacctca gtatctaacc tgaaccagcc tggcttttca      540

aacactccgg ggggaggtag tcccagcctc ccccggaacc ctctaccaat gccttctgac      600

cttctgaagc tttccgaatc ctcccagttg aggcagtagc tgtgtcctct gagggtggat      660

gggaatcttg ggagaagccc aagcaaggga gccctcagag gtggtgtttg gaccaaagca      720

tcggggtggg ggaggggtct gccgctgtcc cccacctgct ggcccccttg tccttcctca      780

ccccctccaa tatagtctcg gagctacaac cgcagcagcc actataaagg gcaatattga      840

tctttctgtc catgtggctc tatcttttaa aacctcaagg ccctccactg tcctaagata      900

aagcctctca taggcactgg ggaccctgca cagtctggcc atgtgaccct ctccccaggc      960

aagctctgaa gtccctgcag gtggaggcca tgcctgtctt aaactcagtt gcatccctgg     1020

tgcccaaagc aacaccagaa ccaagaagga gctccataaa tccttcttgg gtgaagccta     1080

gacaaagccg ccaggtcttg tggctccagg caccagagcc ttgagtactt tctcctgcct     1140

ccaggcattg gctcagggtg aattacaagg ggctactgaa tggctattac tttcatcacg     1200

actgatcccc acctcctcag ggtcaaaggg ctactttctg gaagtctccc caggctgact     1260

ccttctccct gactgcaagg gctcactccc tcctccaagc tcccacaatg cttcatggct     1320

ctgccgctta cctagcttgg cctagagtgg caaatggaac ttctctgatc tcccccaact     1380

agactggagc ccccgaagga tggagaccat gtctgtgcca tctctgtttc ccctgttttc     1440

ccacatacta ggtgctcaat tcatgcctgt gaatggcgtg agcccataat ggatacacag     1500

aggttgcagc agatggtgtg ggtacctcac ccagatatca tccaggccca aggcccctct     1560

ccctgagtga ggccaggtgt tggcagccaa ctgctccaat ctgcctcctt cccctaaata     1620

ctgccctggt ctagtgggag ctgccttccc cctgccccac ctctcccacc aagaggccac     1680

ctgtcactca tggccaggag agtgacacca tggagggtac aattgccagc tcccccgtgt     1740

ctgtgcagga ttgtctgggt tgaatgacac tctcaaattg ttcctgggat cgggctgagg     1800

ccaggcctct cctggaacca cctctctgct tggtctgacc ccttggccta tccagttttc     1860

ctggttccct cacaggtttc tccagaaagt actccctcag taaagcattt gcacaagaat     1920

ccttgtctca ggctctgctt ctaaggaaag agactgaaga gggacaactt tttcctatga     1980

ggactcccaa tctgccattt gtgtgtggct agctgtttcc agccaggggg ctgaggcacc     2040

tgcagtcacc cacactctgg gcctgtggca ccatctgtgc ctcagctgac tgagcagttc     2100

tgagatgtgg tgactcatgt gaagtggtgt cataggaatg aaggactgtg ggcgctgggt     2160

tcaaattcca gttctatgca ccactccagg tagggatacc catgggggca gctgtgcctg     2220

tgtgggggaa cagggtaggg aaatctccat accttctcaa ttttgctgtg aacctaaaac     2280

tgccatataa agataaagtc taggccaggc atggtggctc atgcctgtaa tcccaacact     2340

tagggtggct gaggcaggca gatcacctgg ggtcaggagt tcaagaccag cctgcccaac     2400

atggcaaaac ctcgtctcta ctaaaaatac aaaaattagc caggcatcgt ggtgggtgcc     2460

tgtaatccca gctattcagg aggctgaggc aggagaatca cttggacctg ggaggcagag     2520

gtttcagtga gcccagatcg cgacactgca ctccagcctg ggcaacagag tgacactctg     2580

tctcaaaaaa taaaataaaa taaaataaaa taaaataaaa taaaataaaa aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2747


<210>  40
<211>  145
<212>  PRT
<213>  homo sapiens

<400>  40

Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
1               5                   10                  15      


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
            20                  25                  30          


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
    50                  55                  60                  


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
65                  70                  75                  80  


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
                85                  90                  95      


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
            100                 105                 110         


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
        115                 120                 125             


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
    130                 135                 140                 


Cys 
145 


<210>  41
<211>  3050
<212>  DNA
<213>  homo sapiens

<400>  41
tttttttgct tctgccccag atctttcctg gacagtgcgt ctcagcagtt cagatccggg       60

ggcccccagc tgacagaggg cgtggggggt taaggcatta acccctccca gcctcttcct      120

gaagaaacca cccagccttg gcgcggcgct gggtgacttc gcgtagcagg cagggaactg      180

gccgcggcga gcgggactgg ccattggagt gctccgctgc ggagggaggg gaccccgact      240

cgagtaagtt tgcgagagca ctacgcagtc agtcgggggc agcagcaaga tgcgaagcga      300

gccgtacaga tcccgggctc tccgaacgca acttcgccct gcttgagcga ggctgcggtt      360

tccgaggccc tctccagcca aggaaaagct acacaaaaag cctggatcac tcatcgaacc      420

acccctgaag ccagtgaagg ctctctcgcc tcgccctcta gcgttcgtct ggagtagcgc      480

caccccggct tcctggggac acagggttgg caccatgggg cccaccagcg tcccgctggt      540

caaggcccac cgcagctcgg tctctgacta cgtcaactat gatatcatcg tccggcatta      600

caactacacg ggaaagctga atatcagcgc ggacaaggag aacagcatta aactgacctc      660

ggtggtgttc attctcatct gctgctttat catcctggag aacatctttg tcttgctgac      720

catttggaaa accaagaaat tccaccgacc catgtactat tttattggca atctggccct      780

ctcagacctg ttggcaggag tagcctacac agctaacctg ctcttgtctg gggccaccac      840

ctacaagctc actcccgccc agtggtttct gcgggaaggg agtatgtttg tggccctgtc      900

agcctccgtg ttcagtctcc tcgccatcgc cattgagcgc tatatcacaa tgctgaaaat      960

gaaactccac aacgggagca ataacttccg cctcttcctg ctaatcagcg cctgctgggt     1020

catctccctc atcctgggtg gcctgcctat catgggctgg aactgcatca gtgcgctgtc     1080

cagctgctcc accgtgctgc cgctctacca caagcactat atcctcttct gcaccacggt     1140

cttcactctg cttctgctct ccatcgtcat tctgtactgc agaatctact ccttggtcag     1200

gactcggagc cgccgcctga cgttccgcaa gaacatttcc aaggccagcc gcagctctga     1260

gaagtcgctg gcgctgctca agaccgtaat tatcgtcctg agcgtcttca tcgcctgctg     1320

ggcaccgctc ttcatcctgc tcctgctgga tgtgggctgc aaggtgaaga cctgtgacat     1380

cctcttcaga gcggagtact tcctggtgtt agctgtgctc aactccggca ccaaccccat     1440

catttacact ctgaccaaca aggagatgcg tcgggccttc atccggatca tgtcctgctg     1500

caagtgcccg agcggagact ctgctggcaa attcaagcga cccatcatcg ccggcatgga     1560

attcagccgc agcaaatcgg acaattcctc ccacccccag aaagacgaag gggacaaccc     1620

agagaccatt atgtcttctg gaaacgtcaa ctcttcttcc tagaactgga agctgtccac     1680

ccaccggaag cgctctttac ttggtcgctg gccaccccag tgtttggaaa aaaatctctg     1740

ggcttcgact gctgccaggg aggagctgct gcaagccaga gggaggaagg gggagaatac     1800

gaacagcctg gtggtgtcgg gtgttggtgg gtagagttag ttcctgtgaa caatgcactg     1860

ggaagggtgg agatcaggtc ccggcctgga atatattttc tacccccctg gagctttgat     1920

tttgcactga gccaaaggtc tagcattgtc aagctcctaa agggttcatt tggcccctcc     1980

tcaaagacta atgtccccat gtgaaagcgt ctctttgtct ggagctttga ggagatgttt     2040

tccttcactt tagtttcaaa cccaagtgag tgtgtgcact tctgcttctt tagggatgcc     2100

ctgtacatcc cacaccccac cctcccttcc cttcataccc ctcctcaacg ttcttttact     2160

ttatacttta actacctgag agttatcaga gctggggttg tggaatgatc gatcatctat     2220

agcaaatagg ctatgttgag tacgtaggct gtgggaagat gaagatggtt tggaggtgta     2280

aaacaatgtc cttcgctgag gccaaagttt ccatgtaagc gggatccgtt ttttggaatt     2340

tggttgaagt cactttgatt tctttaaaaa acatcttttc aatgaaatgt gttaccattt     2400

catatccatt gaagccgaaa tctgcataag gaagcccact ttatctaaat gatattagcc     2460

aggatccttg gtgtcctagg agaaacagac aagcaaaaca aagtgaaaac cgaatggatt     2520

aacttttgca aaccaaggga gatttcttag caaatgagtc taacaaatat gacatctgtc     2580

tttggcactt ttgttgatgt ttatttcaga atgttgtgtg attcatttca agcaacaaca     2640

tggttgtatt ttgttgtgtt aaaagtactt ttcttgattt ttgaatgtat ttgtttcagc     2700

agaagtcatt ttattggatt tttctaaccc gtgttaacac cattgaatgt gtatttctta     2760

agaaaatacc accctcttgt gcccttaaaa gcattacttt aactggtagg gaacgccaga     2820

aacttttcag tccagctatt cattagatag taattgaaga tatgtataaa tattacaaag     2880

aataaaaata tattactgtc tctttagtat ggttttcagt gcaattaaac cgagagatgt     2940

cttgtttttt taaaaagaat agtatttaat aggtttctga cttttgtgga tcattttgca     3000

catagcttta tcaactttta aacattaata aactgatttt tttaaagatc                3050


<210>  42
<211>  382
<212>  PRT
<213>  homo sapiens

<400>  42

Met Gly Pro Thr Ser Val Pro Leu Val Lys Ala His Arg Ser Ser Val 
1               5                   10                  15      


Ser Asp Tyr Val Asn Tyr Asp Ile Ile Val Arg His Tyr Asn Tyr Thr 
            20                  25                  30          


Gly Lys Leu Asn Ile Ser Ala Asp Lys Glu Asn Ser Ile Lys Leu Thr 
        35                  40                  45              


Ser Val Val Phe Ile Leu Ile Cys Cys Phe Ile Ile Leu Glu Asn Ile 
    50                  55                  60                  


Phe Val Leu Leu Thr Ile Trp Lys Thr Lys Lys Phe His Arg Pro Met 
65                  70                  75                  80  


Tyr Tyr Phe Ile Gly Asn Leu Ala Leu Ser Asp Leu Leu Ala Gly Val 
                85                  90                  95      


Ala Tyr Thr Ala Asn Leu Leu Leu Ser Gly Ala Thr Thr Tyr Lys Leu 
            100                 105                 110         


Thr Pro Ala Gln Trp Phe Leu Arg Glu Gly Ser Met Phe Val Ala Leu 
        115                 120                 125             


Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile Glu Arg Tyr Ile 
    130                 135                 140                 


Thr Met Leu Lys Met Lys Leu His Asn Gly Ser Asn Asn Phe Arg Leu 
145                 150                 155                 160 


Phe Leu Leu Ile Ser Ala Cys Trp Val Ile Ser Leu Ile Leu Gly Gly 
                165                 170                 175     


Leu Pro Ile Met Gly Trp Asn Cys Ile Ser Ala Leu Ser Ser Cys Ser 
            180                 185                 190         


Thr Val Leu Pro Leu Tyr His Lys His Tyr Ile Leu Phe Cys Thr Thr 
        195                 200                 205             


Val Phe Thr Leu Leu Leu Leu Ser Ile Val Ile Leu Tyr Cys Arg Ile 
    210                 215                 220                 


Tyr Ser Leu Val Arg Thr Arg Ser Arg Arg Leu Thr Phe Arg Lys Asn 
225                 230                 235                 240 


Ile Ser Lys Ala Ser Arg Ser Ser Glu Lys Ser Leu Ala Leu Leu Lys 
                245                 250                 255     


Thr Val Ile Ile Val Leu Ser Val Phe Ile Ala Cys Trp Ala Pro Leu 
            260                 265                 270         


Phe Ile Leu Leu Leu Leu Asp Val Gly Cys Lys Val Lys Thr Cys Asp 
        275                 280                 285             


Ile Leu Phe Arg Ala Glu Tyr Phe Leu Val Leu Ala Val Leu Asn Ser 
    290                 295                 300                 


Gly Thr Asn Pro Ile Ile Tyr Thr Leu Thr Asn Lys Glu Met Arg Arg 
305                 310                 315                 320 


Ala Phe Ile Arg Ile Met Ser Cys Cys Lys Cys Pro Ser Gly Asp Ser 
                325                 330                 335     


Ala Gly Lys Phe Lys Arg Pro Ile Ile Ala Gly Met Glu Phe Ser Arg 
            340                 345                 350         


Ser Lys Ser Asp Asn Ser Ser His Pro Gln Lys Asp Glu Gly Asp Asn 
        355                 360                 365             


Pro Glu Thr Ile Met Ser Ser Gly Asn Val Asn Ser Ser Ser 
    370                 375                 380         


<210>  43
<211>  9071
<212>  DNA
<213>  homo sapiens

<400>  43
atgccgctgc caccgcggag cctgcaggtg ctcctgctgc tgctgctgtt gctgctgctg       60

ctgccgggca tgtgggctga ggcaggcttg cccagggcag gcgggggttc acagcccccc      120

ttccgcacct tctcggccag cgactggggc ctcacccacc tagtggtgca tgagcagaca      180

ggcgaggtgt atgtgggcgc agtgaaccgc atctataagc tgtcggggaa cctgacactg      240

ctgcgggccc acgtcacggg ccctgtggag gacaacgaga agtgctaccc gccgcccagc      300

gtgcagtcct gcccccacgg cctgggcagt actgacaacg tcaacaagct gctgctgctg      360

gactatgccg ctaaccgcct gctggcctgt ggcagcgcct cccagggcat ctgccagttc      420

ctgcgtctgg acgatctctt caaactgggt gagccacacc accgtaagga gcactacctg      480

tccagcgtgc aggaggcagg cagcatggcg ggcgtgctca ttgccgggcc accgggccag      540

ggccaggcca agctcttcgt gggcacaccc atcgatggca agtccgagta cttccccaca      600

ctgtccagcc gtcggctcat ggccaacgag gaggatgccg acatgttcgg cttcgtgtac      660

caggatgagt ttgtgtcatc acagctcaag atcccttcgg acacgctgtc caagttcccg      720

gcctttgaca tctactatgt gtacagcttc cgcagcgagc agtttgtcta ctacctcacg      780

ctgcagctag acacacagct gacctcgcct gatgccgccg gcgagcactt cttcacgtcc      840

aagatcgtgc ggctctgtgt ggacgacccc aaattctact cgtacgttga gttccccatt      900

ggctgcgagc aggcgggtgt ggagtaccgc ctggtgcagg atgcctacct gagccggccc      960

ggccgtgccc tggcccacca gctgggcctg gctgaggacg aggacgtgct gttcactgtg     1020

ttcgcccagg gccagaagaa ccgcgtgaag ccaccaaagg agtcagcact gtgcctgttc     1080

acgctcaggg ccatcaagga gaagattaag gagcgcatcc agtcctgcta ccgtggtgag     1140

ggcaagctct ccctgccgtg gctgctcaac aaggagctgg gctgcatcaa ctcgcccctg     1200

cagatcgatg acgacttctg cgggcaggac ttcaaccagc ccctgggggg cacagtcacc     1260

attgagggga cgcccctgtt cgtggacaag gatgatggcc tgaccgccgt ggctgcctat     1320

gactatcggg gccgcactgt ggtattcgcc ggcacgcgaa gtggccgcat ccgcaagatc     1380

ctggtggacc tctcaaaccc cggtggccgg cctgccctgg cctacgagag cgtcgtggcc     1440

caggagggca gccccatcct gcgagacctc gtcctcagcc ccaaccacca gtacctctac     1500

gccatgaccg agaagcaggt gacgcgggtg cctgtggaga gctgtgtgca gtacacgtcc     1560

tgtgagctgt gtctggggtc acgggacccc cactgtggct ggtgtgtcct gcacagcatc     1620

tgctcgcggc gggacgcctg tgagcgagca gacgagcccc agcgctttgc tgcggacctg     1680

ctgcagtgtg tgcagctgac tgtgcagccc cgcaatgtgt ctgtcaccat gtcccaggtc     1740

ccacttgtgc tgcaggcctg gaacgtgcct gacctctcag ctggcgtcaa ctgctccttc     1800

gaggacttca cggaatctga gagcgtcctg gaggatggcc ggatccactg ccgctcaccc     1860

tccgcccggg aggtggcgcc catcacgcgg ggccagggag accagcgggt ggtgaaactc     1920

tacctaaagt ccaaggagac agggaagaag tttgcgtctg tggacttcgt cttctacaac     1980

tgcagcgtcc accagtcctg cctgtcctgt gtcaacggct cctttccctg ccactggtgc     2040

aaataccgcc acgtgtgcac acacaacgtg gctgactgcg ccttcctgga gggccgtgtc     2100

aacgtgtctg aggactgccc acagatcctg ccctccacgc agatctacgt gccagtggga     2160

gtggtaaaac ccatcaccct ggccgcacgg aacctgccac agccacagtc aggccagcgt     2220

ggatatgagt gcctcttcca catcccgggc agcccggccc gtgtcaccgc cctgcgcttc     2280

aacagctcca gcctgcagtg ccagaattcc tcgtactcct acgaggggaa cgatgtcagc     2340

gacctgccag tgaacctgtc agtcgtgtgg aacggcaact ttgtcattga caacccacag     2400

aacatccagg cgcacctcta caagtgcccg gccctgcgcg agagctgcgg cctctgcctc     2460

aaggccgacc cgcgcttcga gtgcggatgg tgcgtggccg agcgccgctg ctccctgcga     2520

caccactgcg ctgccgacac acctgcatcg tggatgcacg cgcgtcacgg cagcagtcgc     2580

tgcaccgacc ccaagatcct caagctgtcc cccgagacgg gcccgaggca gggcggcacg     2640

cggctcacta tcacaggcga gaacctgggc ctgcgattcg aagacgtgcg tctgggcgtg     2700

cgcgtgggca aggtgctgtg cagccctgtg gagagcgagt acatcagtgc ggagcagatc     2760

gtctgtgaga tcggggacgc cagctccgtg cgtgcccatg acgccctggt ggaggtgtgt     2820

gtgcgggact gctcaccaca ctaccgcgcc ctgtcaccca agcgcttcac cttcgtgaca     2880

ccaaccttct accgtgtgag cccctcccgt gggcctctgt cagggggcac ctggattggc     2940

atcgagggaa gccacctgaa cgcaggcagt gatgtggctg tgtcggtcgg tggccggccc     3000

tgctccttct cctggaggaa ctcccgtgag atccggtgcc tgacaccccc cgggcagagc     3060

cctggcagcg ctcccatcat catcaacatc aaccgcgccc agctcaccaa ccctgaggtg     3120

aagtacaact acaccgagga ccccaccatc ctgaggatcg accccgagtg gagcatcaac     3180

agcggtggga ccctcctgac ggtcacaggc accaacctgg ccactgtccg tgaaccccga     3240

atccgggcca agtatggagg cattgagagg gagaacggct gcctggtgta caatgacacc     3300

accatggtat gccgcgcccc gtctgtggcc aaccctgtgc gcagcccacc agagctgggg     3360

gagcggccgg atgagctggg cttcgtcatg gacaacgtgc gctccctgct tgtgctcaac     3420

tccacctcct tcctctacta ccctgacccc gtactggagc cactcagccc cactggcctg     3480

ctggagctga agcccagctc cccactcatc ctcaagggcc ggaacctctt gccacctgca     3540

cccggcaact cccgactcaa ctacacggtg ctcatcggct ccacaccctg taccctcacc     3600

gtgtcggaga cgcaactgct gtgcgaggcg cccaacctca ctgggcagca caaggtcacg     3660

gtgcgggcag gtggcttcga gttctcgcca gggacactgc aggtgtactc ggacagcctg     3720

ctgacgctgc ctgccattgt gggcattggc ggaggcgggg gtctcctgct gctggtcatc     3780

gtggctgtgc tcatcgccta caagcgcaag tcacgagatg ctgaccgcac actcaagcgg     3840

ctgcagctcc agatggacaa cctggagtcc cgcgtggccc tcgaatgcaa ggaagccttt     3900

gcagagctgc agacagacat ccacgagctg accaatgacc tggacggtgc cggcatcccc     3960

ttccttgact accggacata tgccatgcgg gtgctctttc ctgggatcga ggaccaccct     4020

gtgctcaagg agatggaggt gcaggccaat gtggagaagt cgctgacact gttcgggcag     4080

ctgctgacca agaagcactt cctgctgacc ttcatccgca cgctggaggc acagcgcagc     4140

ttctccatgc gcgaccgcgg gaatgtggcc tcgctcatca tgacggccct gcagggcgag     4200

atggaatacg ccacaggcgt gctcaagcag ctgctttccg acctcatcga gaagaacctg     4260

gagagcaaga accaccccaa gctgctactg cgccggactg agtcggtggc agagaagatg     4320

ctaactaact ggttcacctt cctcttgtat aagttcctca aggagtgcgc tggggagccg     4380

ctgttcatgc tgtactgcgc catcaagcag cagatggaga agggccccat tgacgccatc     4440

acgggtgagg cacgctactc cctgagtgag gacaagctca tccggcagca gattgactac     4500

aagacactga ccctgaactg tgtgaaccct gagaatgaga atgcacctga ggtgccggtg     4560

aaggggctgg actgtgacac ggtcacccag gccaaggaga agctgctgga cgctgcctac     4620

aagggcgtgc cctactccca gcggcccaag gccgcggaca tggacctgga gtggcgccag     4680

ggccgcatgg cgcgcatcat cctgcaggac gaggacgtca ccaccaagat tgacaacgat     4740

tggaagaggc tgaacacact ggctcactac caggtgacag acgggtcctc ggtggcactg     4800

gtgcccaagc agacgtccgc ctacaacatc tccaactcct ccaccttcac caagtccctc     4860

agcagatacg agagcatgct gcgcacggcc agcagccccg acagcctgcg ctcgcgcacg     4920

cccatgatca cgcccgacct ggagagcggc accaagctgt ggcacctggt gaagaaccac     4980

gaccacctgg accagcgtga gggtgaccgc ggcagcaaga tggtctcgga gatctacttg     5040

acacggctac tggccaccaa gggcacactg cagaagtttg tggacgacct gtttgagacc     5100

atcttcagca cggcacaccg gggctcagcc ctgccgctgg ccatcaagta catgttcgac     5160

ttcctggatg agcaggccga caagcaccag atccacgatg ctgacgtgcg ccacacctgg     5220

aagagcaact gcctgcccct gcgcttctgg gtgaacgtga tcaagaaccc acagtttgtg     5280

ttcgacattc acaagaacag catcacggac gcctgcttgt cggtggtggc ccagaccttc     5340

atggactcct gctccacctc tgagcacaag ctgggcaagg actcaccctc caacaagctg     5400

ctctacgcca aggacatccc caactacaag agctgggtgg agaggtacta tgcagacatc     5460

gccaagatgc cagccatcag cgaccaggac atgagtgcgt atctggctga gcagtcccgc     5520

ctgcacctga gccagttcaa cagcatgagc gccttgcacg agatctactc ctacatcacc     5580

aagtacaagg atgagatcct ggcagccctg gagaaggatg agcaggcgcg gcggcagcgg     5640

ctgcggagca agctggagca ggtggtggac acgatggccc tgagcagctg agccccagct     5700

gtgatcatcc agcatgatgc agcgtgagga cagctgagca gggaccggga cagccctcac     5760

cgcatgcgtg tggagtgtcc ggtggtgctc gggccgccgc agtgcagcga ctgcccggcc     5820

ctccctcccc tgcctcaccc ggtcgggtcc cggctcttcc tgtgtggagg tgatggtacc     5880

tgccacacca cagctgcgca cacagctgct tgctcagggg ccgggacagc actgggtgct     5940

caggctggcc aaggaccttc attgcctggc aagagctgcc cagtggcctt catgggagaa     6000

gggctgacct ctgaggggct gaggggtgag gccagggccc tccaggggga ggggtagcca     6060

gcttgggctg tccccttgag accaggacaa gaggctgggg gtgtcagcat tcccagcttt     6120

ccaagctgcc cccaggcggc agagtctgag ggtcccgggg cccggttggc agctggagaa     6180

agaggcaaaa agcccgtagc cgggcaagag gagctcaagt cggtctgggc ccgttgccac     6240

cgactcccac ctccagcacc catgcccgct gcaccgctgc catcctcaga ttcaccgcgt     6300

gctctgcgcg gccgaggccg gagcaccaca tccacctcgc cccagagagg ctctgctccc     6360

tcctatggag gggctgtggg ccaggctgct cagactcctg ggtggcttcc agacggaccg     6420

ggcagcccct ctccgtcctc agggctgtgc ctctgggagc cactgggcca ggggccccgg     6480

gtcgcagaga gcacgttccc gttatttatt cccctccgcg tcctacacag gctgccctgg     6540

cagctgtctt caagggtagg ctgagctccc caccctggag cccctgaggg cggcccctga     6600

gcactcctct ctctccactc tctctgtccc tgccccagcg gcttccagtg tggcatctca     6660

gcagtgtcct ggcccctcca gagcagtggg acatctgggg actgtttttg tgtttagggg     6720

aaaaaattct gctgcactct gcttgggcct tgaggtctgt ggcagggctc ctctggcccg     6780

cagtggcctg gatctatctg ggccatgagt gacgggcagt gaccagaggg actggaggcc     6840

agcggtgtcc acccttgccc tcagcaagag agaatgcatt cttaaaagaa agctgtacat     6900

gtatatatat gcatatatat atatgtggct ctagcctcag gctccagccc cagtggggta     6960

ctgtacagtt aactgaagaa gaattttaaa gacgatttga acaagaaaat gaaggcagtg     7020

ggaaagcaat gccaaatggt tgtggagaaa gtggccggag cctccctgga gtggagcagc     7080

cctgaagcct gtgccccccg acctgcgggc cgctgttttg gtttgacatg acaaggaaag     7140

gacttcctgc tgaccctgag agcctctggg gtgccgcggc accacggggc atgcatgatt     7200

gtgctagcgt ttagtctgag ttgatctttt taaaactgca agtgttgaat actagaggtt     7260

gttagaccct tttttatgtt ttttaattaa tcagtcactt gtaaaagcaa acaagcggtc     7320

catccccttt tcaaggtcac ttttttgatg gtaccgaaga tcccatggac attaagggac     7380

agctaactgt ggccagactc agccccatgt ccttggccag gcccaaggag aggactcggc     7440

cccatggggt gtgccagtct tgcagtccgc cccagctgag tagcgtgagc cagatgacgc     7500

cacagagacc cgcctcttcc ctgaacgcgg gtcggtgtgg agtcagtgac tgctgactca     7560

gggagctcct tggccccgtg ggcactgtgc cagggctggg gccttctgct gctgccacac     7620

ccagctcagg cctgggccag cccctgcccc cagcccactg agggggtggg cttactccct     7680

gggcagtctt gggggccaga gctgaggcca gtccatatta cagtggctgg gctgtttttt     7740

tcagtagccc ctagcattgg ctgggattcc tgttcctggg tgcgcctcca cctcccttct     7800

gatgtttcct ggctatggtg gggtgggaac ctcagtttcc cccaaagtct tccctggatg     7860

ctggcttcag gttgaagtcc ctggttcttc cagttcctca cgggttaggt aggggctcct     7920

gcatcacctt cagaatccag ttccaacccc cactctcctt aggccttgtg ctctgctctg     7980

ccctgccagg ctgcccttgt ccatgtgagt agcatgggcg ggtggtgggg acggcagtgg     8040

tgatgaaggg ggtgcaccac aggcctcatg aagcagttcc cacatgggcg tgtggctggg     8100

gcgtggccac cacagagcac atggctgtgt ctaggcgcaa gcactttagc agtatctgtt     8160

tacatgcgca aggatcaagc cgactacctg tgctgtctac tgggacagca gtctccgagc     8220

tactccgtac ctccctctgc caggtcgtgg agttaggccc cagtccctac ttgtcactgg     8280

ttcccactgt gctcctaact gtgcagcacc tgggagctct ggcctggggc tggaggccct     8340

ggtaggagct gcagttggag gccgttctgt gcccagcagc ggtgagcggc tcccatgggc     8400

cctgtgtctg cagggagcca gggctgcggc acatgtgctg tgaaactggc acccacctgg     8460

cgtgctgctg ccgccacttg cttcctgcag cacctcctac cctgctccgt gtcctccctc     8520

tccccgcgcc tggctcagga gtgctggaaa agctcacgcc tcggcctggg agcctggcct     8580

cttgatatac ctcgagcttc ccctgtgctc cccagcccca ggaccactgg ccccttggcc     8640

tgaggggctg ggggccccac gacctgcagc gtcgagtccg ggagagagcc cggagcggcg     8700

tgccatctcg gctcggcctt gctgagagcc tccgccctgg ctttctccct gtctggattc     8760

agtggctcac gttggtgcta cacagctaga atagatatat ttagagagag agatattttt     8820

aagacaaagc ccacaattag ctgtccttta acaccgcaga accccctccc agaagaagag     8880

cgatccctcg gacggtccgg gcgggcaccc tcagccgggc tctttgcaga agcagcaccg     8940

ctgactgtgg gcccggccct cagatgtgta catatacggc tatttcctat tttactgttc     9000

ttcagattta gtacttgtaa ataaacacac acattaagga gagattaaac atttttgcta     9060

aaagctaaaa a                                                          9071


<210>  44
<211>  1896
<212>  PRT
<213>  homo sapiens

<400>  44

Met Pro Leu Pro Pro Arg Ser Leu Gln Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Gly Met Trp Ala Glu Ala Gly Leu Pro Arg 
            20                  25                  30          


Ala Gly Gly Gly Ser Gln Pro Pro Phe Arg Thr Phe Ser Ala Ser Asp 
        35                  40                  45              


Trp Gly Leu Thr His Leu Val Val His Glu Gln Thr Gly Glu Val Tyr 
    50                  55                  60                  


Val Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Gly Asn Leu Thr Leu 
65                  70                  75                  80  


Leu Arg Ala His Val Thr Gly Pro Val Glu Asp Asn Glu Lys Cys Tyr 
                85                  90                  95      


Pro Pro Pro Ser Val Gln Ser Cys Pro His Gly Leu Gly Ser Thr Asp 
            100                 105                 110         


Asn Val Asn Lys Leu Leu Leu Leu Asp Tyr Ala Ala Asn Arg Leu Leu 
        115                 120                 125             


Ala Cys Gly Ser Ala Ser Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro His His Arg Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Ser Val Gln Glu Ala Gly Ser Met Ala Gly Val Leu Ile Ala Gly 
                165                 170                 175     


Pro Pro Gly Gln Gly Gln Ala Lys Leu Phe Val Gly Thr Pro Ile Asp 
            180                 185                 190         


Gly Lys Ser Glu Tyr Phe Pro Thr Leu Ser Ser Arg Arg Leu Met Ala 
        195                 200                 205             


Asn Glu Glu Asp Ala Asp Met Phe Gly Phe Val Tyr Gln Asp Glu Phe 
    210                 215                 220                 


Val Ser Ser Gln Leu Lys Ile Pro Ser Asp Thr Leu Ser Lys Phe Pro 
225                 230                 235                 240 


Ala Phe Asp Ile Tyr Tyr Val Tyr Ser Phe Arg Ser Glu Gln Phe Val 
                245                 250                 255     


Tyr Tyr Leu Thr Leu Gln Leu Asp Thr Gln Leu Thr Ser Pro Asp Ala 
            260                 265                 270         


Ala Gly Glu His Phe Phe Thr Ser Lys Ile Val Arg Leu Cys Val Asp 
        275                 280                 285             


Asp Pro Lys Phe Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Glu Gln 
    290                 295                 300                 


Ala Gly Val Glu Tyr Arg Leu Val Gln Asp Ala Tyr Leu Ser Arg Pro 
305                 310                 315                 320 


Gly Arg Ala Leu Ala His Gln Leu Gly Leu Ala Glu Asp Glu Asp Val 
                325                 330                 335     


Leu Phe Thr Val Phe Ala Gln Gly Gln Lys Asn Arg Val Lys Pro Pro 
            340                 345                 350         


Lys Glu Ser Ala Leu Cys Leu Phe Thr Leu Arg Ala Ile Lys Glu Lys 
        355                 360                 365             


Ile Lys Glu Arg Ile Gln Ser Cys Tyr Arg Gly Glu Gly Lys Leu Ser 
    370                 375                 380                 


Leu Pro Trp Leu Leu Asn Lys Glu Leu Gly Cys Ile Asn Ser Pro Leu 
385                 390                 395                 400 


Gln Ile Asp Asp Asp Phe Cys Gly Gln Asp Phe Asn Gln Pro Leu Gly 
                405                 410                 415     


Gly Thr Val Thr Ile Glu Gly Thr Pro Leu Phe Val Asp Lys Asp Asp 
            420                 425                 430         


Gly Leu Thr Ala Val Ala Ala Tyr Asp Tyr Arg Gly Arg Thr Val Val 
        435                 440                 445             


Phe Ala Gly Thr Arg Ser Gly Arg Ile Arg Lys Ile Leu Val Asp Leu 
    450                 455                 460                 


Ser Asn Pro Gly Gly Arg Pro Ala Leu Ala Tyr Glu Ser Val Val Ala 
465                 470                 475                 480 


Gln Glu Gly Ser Pro Ile Leu Arg Asp Leu Val Leu Ser Pro Asn His 
                485                 490                 495     


Gln Tyr Leu Tyr Ala Met Thr Glu Lys Gln Val Thr Arg Val Pro Val 
            500                 505                 510         


Glu Ser Cys Val Gln Tyr Thr Ser Cys Glu Leu Cys Leu Gly Ser Arg 
        515                 520                 525             


Asp Pro His Cys Gly Trp Cys Val Leu His Ser Ile Cys Ser Arg Arg 
    530                 535                 540                 


Asp Ala Cys Glu Arg Ala Asp Glu Pro Gln Arg Phe Ala Ala Asp Leu 
545                 550                 555                 560 


Leu Gln Cys Val Gln Leu Thr Val Gln Pro Arg Asn Val Ser Val Thr 
                565                 570                 575     


Met Ser Gln Val Pro Leu Val Leu Gln Ala Trp Asn Val Pro Asp Leu 
            580                 585                 590         


Ser Ala Gly Val Asn Cys Ser Phe Glu Asp Phe Thr Glu Ser Glu Ser 
        595                 600                 605             


Val Leu Glu Asp Gly Arg Ile His Cys Arg Ser Pro Ser Ala Arg Glu 
    610                 615                 620                 


Val Ala Pro Ile Thr Arg Gly Gln Gly Asp Gln Arg Val Val Lys Leu 
625                 630                 635                 640 


Tyr Leu Lys Ser Lys Glu Thr Gly Lys Lys Phe Ala Ser Val Asp Phe 
                645                 650                 655     


Val Phe Tyr Asn Cys Ser Val His Gln Ser Cys Leu Ser Cys Val Asn 
            660                 665                 670         


Gly Ser Phe Pro Cys His Trp Cys Lys Tyr Arg His Val Cys Thr His 
        675                 680                 685             


Asn Val Ala Asp Cys Ala Phe Leu Glu Gly Arg Val Asn Val Ser Glu 
    690                 695                 700                 


Asp Cys Pro Gln Ile Leu Pro Ser Thr Gln Ile Tyr Val Pro Val Gly 
705                 710                 715                 720 


Val Val Lys Pro Ile Thr Leu Ala Ala Arg Asn Leu Pro Gln Pro Gln 
                725                 730                 735     


Ser Gly Gln Arg Gly Tyr Glu Cys Leu Phe His Ile Pro Gly Ser Pro 
            740                 745                 750         


Ala Arg Val Thr Ala Leu Arg Phe Asn Ser Ser Ser Leu Gln Cys Gln 
        755                 760                 765             


Asn Ser Ser Tyr Ser Tyr Glu Gly Asn Asp Val Ser Asp Leu Pro Val 
    770                 775                 780                 


Asn Leu Ser Val Val Trp Asn Gly Asn Phe Val Ile Asp Asn Pro Gln 
785                 790                 795                 800 


Asn Ile Gln Ala His Leu Tyr Lys Cys Pro Ala Leu Arg Glu Ser Cys 
                805                 810                 815     


Gly Leu Cys Leu Lys Ala Asp Pro Arg Phe Glu Cys Gly Trp Cys Val 
            820                 825                 830         


Ala Glu Arg Arg Cys Ser Leu Arg His His Cys Ala Ala Asp Thr Pro 
        835                 840                 845             


Ala Ser Trp Met His Ala Arg His Gly Ser Ser Arg Cys Thr Asp Pro 
    850                 855                 860                 


Lys Ile Leu Lys Leu Ser Pro Glu Thr Gly Pro Arg Gln Gly Gly Thr 
865                 870                 875                 880 


Arg Leu Thr Ile Thr Gly Glu Asn Leu Gly Leu Arg Phe Glu Asp Val 
                885                 890                 895     


Arg Leu Gly Val Arg Val Gly Lys Val Leu Cys Ser Pro Val Glu Ser 
            900                 905                 910         


Glu Tyr Ile Ser Ala Glu Gln Ile Val Cys Glu Ile Gly Asp Ala Ser 
        915                 920                 925             


Ser Val Arg Ala His Asp Ala Leu Val Glu Val Cys Val Arg Asp Cys 
    930                 935                 940                 


Ser Pro His Tyr Arg Ala Leu Ser Pro Lys Arg Phe Thr Phe Val Thr 
945                 950                 955                 960 


Pro Thr Phe Tyr Arg Val Ser Pro Ser Arg Gly Pro Leu Ser Gly Gly 
                965                 970                 975     


Thr Trp Ile Gly Ile Glu Gly Ser His Leu Asn Ala Gly Ser Asp Val 
            980                 985                 990         


Ala Val Ser Val Gly Gly Arg Pro  Cys Ser Phe Ser Trp  Arg Asn Ser 
        995                 1000                 1005             


Arg Glu  Ile Arg Cys Leu Thr  Pro Pro Gly Gln Ser  Pro Gly Ser 
    1010                 1015                 1020             


Ala Pro  Ile Ile Ile Asn Ile  Asn Arg Ala Gln Leu  Thr Asn Pro 
    1025                 1030                 1035             


Glu Val  Lys Tyr Asn Tyr Thr  Glu Asp Pro Thr Ile  Leu Arg Ile 
    1040                 1045                 1050             


Asp Pro  Glu Trp Ser Ile Asn  Ser Gly Gly Thr Leu  Leu Thr Val 
    1055                 1060                 1065             


Thr Gly  Thr Asn Leu Ala Thr  Val Arg Glu Pro Arg  Ile Arg Ala 
    1070                 1075                 1080             


Lys Tyr  Gly Gly Ile Glu Arg  Glu Asn Gly Cys Leu  Val Tyr Asn 
    1085                 1090                 1095             


Asp Thr  Thr Met Val Cys Arg  Ala Pro Ser Val Ala  Asn Pro Val 
    1100                 1105                 1110             


Arg Ser  Pro Pro Glu Leu Gly  Glu Arg Pro Asp Glu  Leu Gly Phe 
    1115                 1120                 1125             


Val Met  Asp Asn Val Arg Ser  Leu Leu Val Leu Asn  Ser Thr Ser 
    1130                 1135                 1140             


Phe Leu  Tyr Tyr Pro Asp Pro  Val Leu Glu Pro Leu  Ser Pro Thr 
    1145                 1150                 1155             


Gly Leu  Leu Glu Leu Lys Pro  Ser Ser Pro Leu Ile  Leu Lys Gly 
    1160                 1165                 1170             


Arg Asn  Leu Leu Pro Pro Ala  Pro Gly Asn Ser Arg  Leu Asn Tyr 
    1175                 1180                 1185             


Thr Val  Leu Ile Gly Ser Thr  Pro Cys Thr Leu Thr  Val Ser Glu 
    1190                 1195                 1200             


Thr Gln  Leu Leu Cys Glu Ala  Pro Asn Leu Thr Gly  Gln His Lys 
    1205                 1210                 1215             


Val Thr  Val Arg Ala Gly Gly  Phe Glu Phe Ser Pro  Gly Thr Leu 
    1220                 1225                 1230             


Gln Val  Tyr Ser Asp Ser Leu  Leu Thr Leu Pro Ala  Ile Val Gly 
    1235                 1240                 1245             


Ile Gly  Gly Gly Gly Gly Leu  Leu Leu Leu Val Ile  Val Ala Val 
    1250                 1255                 1260             


Leu Ile  Ala Tyr Lys Arg Lys  Ser Arg Asp Ala Asp  Arg Thr Leu 
    1265                 1270                 1275             


Lys Arg  Leu Gln Leu Gln Met  Asp Asn Leu Glu Ser  Arg Val Ala 
    1280                 1285                 1290             


Leu Glu  Cys Lys Glu Ala Phe  Ala Glu Leu Gln Thr  Asp Ile His 
    1295                 1300                 1305             


Glu Leu  Thr Asn Asp Leu Asp  Gly Ala Gly Ile Pro  Phe Leu Asp 
    1310                 1315                 1320             


Tyr Arg  Thr Tyr Ala Met Arg  Val Leu Phe Pro Gly  Ile Glu Asp 
    1325                 1330                 1335             


His Pro  Val Leu Lys Glu Met  Glu Val Gln Ala Asn  Val Glu Lys 
    1340                 1345                 1350             


Ser Leu  Thr Leu Phe Gly Gln  Leu Leu Thr Lys Lys  His Phe Leu 
    1355                 1360                 1365             


Leu Thr  Phe Ile Arg Thr Leu  Glu Ala Gln Arg Ser  Phe Ser Met 
    1370                 1375                 1380             


Arg Asp  Arg Gly Asn Val Ala  Ser Leu Ile Met Thr  Ala Leu Gln 
    1385                 1390                 1395             


Gly Glu  Met Glu Tyr Ala Thr  Gly Val Leu Lys Gln  Leu Leu Ser 
    1400                 1405                 1410             


Asp Leu  Ile Glu Lys Asn Leu  Glu Ser Lys Asn His  Pro Lys Leu 
    1415                 1420                 1425             


Leu Leu  Arg Arg Thr Glu Ser  Val Ala Glu Lys Met  Leu Thr Asn 
    1430                 1435                 1440             


Trp Phe  Thr Phe Leu Leu Tyr  Lys Phe Leu Lys Glu  Cys Ala Gly 
    1445                 1450                 1455             


Glu Pro  Leu Phe Met Leu Tyr  Cys Ala Ile Lys Gln  Gln Met Glu 
    1460                 1465                 1470             


Lys Gly  Pro Ile Asp Ala Ile  Thr Gly Glu Ala Arg  Tyr Ser Leu 
    1475                 1480                 1485             


Ser Glu  Asp Lys Leu Ile Arg  Gln Gln Ile Asp Tyr  Lys Thr Leu 
    1490                 1495                 1500             


Thr Leu  Asn Cys Val Asn Pro  Glu Asn Glu Asn Ala  Pro Glu Val 
    1505                 1510                 1515             


Pro Val  Lys Gly Leu Asp Cys  Asp Thr Val Thr Gln  Ala Lys Glu 
    1520                 1525                 1530             


Lys Leu  Leu Asp Ala Ala Tyr  Lys Gly Val Pro Tyr  Ser Gln Arg 
    1535                 1540                 1545             


Pro Lys  Ala Ala Asp Met Asp  Leu Glu Trp Arg Gln  Gly Arg Met 
    1550                 1555                 1560             


Ala Arg  Ile Ile Leu Gln Asp  Glu Asp Val Thr Thr  Lys Ile Asp 
    1565                 1570                 1575             


Asn Asp  Trp Lys Arg Leu Asn  Thr Leu Ala His Tyr  Gln Val Thr 
    1580                 1585                 1590             


Asp Gly  Ser Ser Val Ala Leu  Val Pro Lys Gln Thr  Ser Ala Tyr 
    1595                 1600                 1605             


Asn Ile  Ser Asn Ser Ser Thr  Phe Thr Lys Ser Leu  Ser Arg Tyr 
    1610                 1615                 1620             


Glu Ser  Met Leu Arg Thr Ala  Ser Ser Pro Asp Ser  Leu Arg Ser 
    1625                 1630                 1635             


Arg Thr  Pro Met Ile Thr Pro  Asp Leu Glu Ser Gly  Thr Lys Leu 
    1640                 1645                 1650             


Trp His  Leu Val Lys Asn His  Asp His Leu Asp Gln  Arg Glu Gly 
    1655                 1660                 1665             


Asp Arg  Gly Ser Lys Met Val  Ser Glu Ile Tyr Leu  Thr Arg Leu 
    1670                 1675                 1680             


Leu Ala  Thr Lys Gly Thr Leu  Gln Lys Phe Val Asp  Asp Leu Phe 
    1685                 1690                 1695             


Glu Thr  Ile Phe Ser Thr Ala  His Arg Gly Ser Ala  Leu Pro Leu 
    1700                 1705                 1710             


Ala Ile  Lys Tyr Met Phe Asp  Phe Leu Asp Glu Gln  Ala Asp Lys 
    1715                 1720                 1725             


His Gln  Ile His Asp Ala Asp  Val Arg His Thr Trp  Lys Ser Asn 
    1730                 1735                 1740             


Cys Leu  Pro Leu Arg Phe Trp  Val Asn Val Ile Lys  Asn Pro Gln 
    1745                 1750                 1755             


Phe Val  Phe Asp Ile His Lys  Asn Ser Ile Thr Asp  Ala Cys Leu 
    1760                 1765                 1770             


Ser Val  Val Ala Gln Thr Phe  Met Asp Ser Cys Ser  Thr Ser Glu 
    1775                 1780                 1785             


His Lys  Leu Gly Lys Asp Ser  Pro Ser Asn Lys Leu  Leu Tyr Ala 
    1790                 1795                 1800             


Lys Asp  Ile Pro Asn Tyr Lys  Ser Trp Val Glu Arg  Tyr Tyr Ala 
    1805                 1810                 1815             


Asp Ile  Ala Lys Met Pro Ala  Ile Ser Asp Gln Asp  Met Ser Ala 
    1820                 1825                 1830             


Tyr Leu  Ala Glu Gln Ser Arg  Leu His Leu Ser Gln  Phe Asn Ser 
    1835                 1840                 1845             


Met Ser  Ala Leu His Glu Ile  Tyr Ser Tyr Ile Thr  Lys Tyr Lys 
    1850                 1855                 1860             


Asp Glu  Ile Leu Ala Ala Leu  Glu Lys Asp Glu Gln  Ala Arg Arg 
    1865                 1870                 1875             


Gln Arg  Leu Arg Ser Lys Leu  Glu Gln Val Val Asp  Thr Met Ala 
    1880                 1885                 1890             


Leu Ser  Ser 
    1895     


<210>  45
<211>  5010
<212>  DNA
<213>  homo sapiens

<400>  45
ccccgggagc ccagccagag cgagcgccgg ggccgggcgc gcaggagtga aaaggaggcg       60

gcggccgcag ctgcgagcaa cagatccgga cgccgcgagc tgacccgctc tgctgttggg      120

cgattttttt ttaattgcag aaaaatttat taaattggaa aatcttgcgt ttttcaatgg      180

cgctggcccc gggtcagcgg gcgattttct ctgcatcaag atgggctttg ccgtttccgt      240

agtgggcacc agtggtggcc tgattgtcag tcttctcccg gcatttttaa ggccaggagc      300

cgagcgctgc ttgtaggcga ataccctaca gagcggtttg gctttttaaa ttactgttat      360

tattttgggc agagaacagt cggtctggtg caccccgtcc tcgctgcaga agaggctgcg      420

agtccgaggt gggtctctcg gaaggtgaaa ttccttctgg ggtgagcgag ccccggcccc      480

gcgcgcagtc cagcggcccc gcgtgtgtgc cctcgccctg ccggagccgg gaaaatggag      540

gctgtgattg agaaggaatg cagcgcgctc ggaggcctct tccagaccat catcagcgac      600

atgaagggga gctatccagt ttgggaagat ttcataaaca aagcaggaaa gctgcagtcc      660

cagcttcgga caacagtagt agcagcagct gccttcttgg acgcctttca gaaagtggct      720

gacatggcca ccaacacacg tggtgggacc agggagattg gatctgctct caccaggatg      780

tgcatgaggc acagaagcat tgaagccaag ctgaggcagt tttcgagcgc tttaattgat      840

tgtctgataa acccacttca agaacagatg gaagaatgga agaaagtggc caaccagctg      900

gataaagacc acgcaaaaga atataagaaa gcccgccaag agataaaaaa gaagtcctcg      960

gatacgctga aactgcagaa gaaagcaaaa aaagggagag gtgatatcca gcctcagttg     1020

gacagtgctc tccaagatgt caatgataag tatctcttat tggaagaaac agaaaagcag     1080

gctgtccgga aggctttgat tgaagaacgt ggccgattct gtaccttcat ctctatgctg     1140

cggccagtga ttgaagaaga aatctcaatg ctaggggaaa taacccacct tcagaccatc     1200

tcggaagatc taaaaagcct gaccatggac cctcacaaac tgccctcctc aagtgaacag     1260

gtgattctgg acttgaaagg ttctgattac agctggtcgt atcagacgcc accctcttcc     1320

cccagcacca ccatgtccag aaagtccagt gtctgcagca gcctgaacag tgtcaacagc     1380

agtgactccc ggtccagcgg ctcccactcg cattccccca gctcacatta ccgctaccgc     1440

agctccaacc tggcccagca ggctcctgtg aggctgtcca gcgtgtcctc ccatgactca     1500

ggattcatat cccaggatgc cttccagtcc aagtcaccat cccccatgcc gccagaggcc     1560

cccaaccagt tgtctaacgg gttttctcac tatagtttat caagtgagtc ccacgtgggg     1620

cccacgggtg caggcctttt ccctcattgc ctgcctgcct cccgcctgct ccctcgggtc     1680

acctctgtcc accttccaga ctacgctcat tattacacca ttgggcccgg catgttcccg     1740

tcatctcaga tccctagctg gaaggactgg gctaagcctg ggccctatga ccagcctctg     1800

gtgaacaccc tgcagcgccg caaagagaag cgagaaccgg accccaacgg gggaggaccc     1860

actaccgcca gcggcccacc tgcagcagct gaggaggctc agagaccacg gagcatgact     1920

gtatcggctg ccaccaggcc tggtgaggag atggaggctt gtgaggagct ggccctggcc     1980

ctgtctcggg gcctgcagct ggacacccag aggagcagcc gggactcgct tcagtgctcc     2040

agcggctaca gcacccagac aaccaccccc tgctgctctg aggacaccat cccttcccaa     2100

gtttcagatt atgattattt ctctgtaagt ggtgaccagg aggcagatca gcaggagttc     2160

gacaagtcct ccaccattcc aagaaacagc gacatcagcc agtcctaccg acggatgttc     2220

caagccaagc gtccagcctc aactgctggc ctccccacca ccctgggacc tgctatggtc     2280

actccagggg ttgcaactat ccgacggacc ccttccacca agccttctgt ccgccgggga     2340

accattggag ctggtcccat ccccatcaag acacccgtga tccctgtcaa gaccccaacc     2400

gtcccagacc tcccaggggt gttgccagcc cctccagatg ggccagaaga gcggggggag     2460

cacagccctg agtcgccatc tgtgggtgag ggcccccaag gtgtcaccag catgccctcc     2520

tcaatgtgga gcggccaagc ttccgttaac cctccacttc caggcccgaa gcccagtatc     2580

cctgaggagc acagacaggc aattccagaa agtgaagctg aagaccagga acgggaaccc     2640

ccaagtgcca ctgtctcccc aggccagatt ccagagagtg accctgcaga cctgagccca     2700

agggatactc cacaaggaga agacatgctg aacgccatcc gaaggggcgt gaaactgaag     2760

aagaccacga caaacgatcg ctcagcccct cgcttttctt aggttcacaa gaaatgcgcc     2820

ggtggggaat gaactgtttc attaataaaa cctaatttgt cttgatccat tccactctat     2880

aataaaacaa aagattttgt aggcaactcg gaatatagct cttttgaaag tactcgacac     2940

ctttagataa gaattaaaac caacctatgt aactgacata atcttgatct tttaatttgt     3000

aaatattgac aattttcttt ctgcacattt taatcttagt ttcccttttg atttttctga     3060

aggtgccaaa ttccatttaa cttttttaca agtctttgta aaattttaaa tgcataaagg     3120

gggttggggc aggggaacca cgaagtagtt aattttagaa aaggatttac tatacttcac     3180

tcttcttttt ttttccccac aagcttttgt agatgcattg tagtagtcta gcttagaagc     3240

aaatgcaagt tattttaatg tacaaactaa atgggtaaga ggtaaaatct tcatttaaat     3300

atactatgtt ctggatgaaa agagcaggag taacaattga tgagcaatat tcagagtgaa     3360

gtaaatctgg aaatggtaga ctgtgttggg attgggggga gggccatggg aggggtacat     3420

cgtcaacata gccgatcctg ttacatttaa gagtagcctc gtaggttgaa tttcttctgg     3480

tagcttcatg gtaaatgcat ccgaataagc catactggat tgcagtgttt gtttctgtag     3540

ggtgtttaag gacttgactt cctttctccc atgattcctc tggactgcac acagcaccca     3600

caaccagccc catgcatgct gctgcctctg ggcagtcgta gaatctccca cttcagtttc     3660

tcgttgattg tactcacctt tatggaatcc aaatacatcc aaaagggtaa ggcagtttta     3720

aaaatgtgaa aacatttaaa aatgataata gcagggaatt cttagattat agtaaatgcc     3780

ttttacttaa ctgtgcccag caggctgggt gcgttaaaaa gcccaagtat tttgaaaaaa     3840

ctcgaacaga tttgacaagg gtagccagct tggagtctag caacttgcca atgtgtttac     3900

caatctgggg gcttgttttt cttttcttct ttcaaataaa tggcagttaa ctggctttac     3960

agtaaacatt gaagagagga ggatttgttt attgtcactg ggaatctgac cactatactg     4020

tccttttttt gtattctggg taaatgtttt ttggaaaaga tttgtctttt ctaagtggaa     4080

gttaaatttg ttatactgcc catcccctaa agccaacaga gatttgtaga tttaaaggga     4140

tcacatttga agacaatagt gtttaagaaa gcaagcaagt cccttagcag tcaggtcata     4200

acagggcaca tttctgaccg aaccctctca aggcagagga ggagtttggt gggtttcata     4260

caccctgcag attcctgttg gctctaaccc tcaattacct aatcttatgc tttaacacat     4320

aactgcattg gatgtgagag taacgtaccg tatggtcatt gttctatata ttaacattga     4380

acactgctgc gattgctcaa ggacatttta tgttacggct ttaaagcaaa ggcatgatta     4440

ttagaaacta tttaagcttt tttctttgaa aaacaagctc cttttacaga atataaacaa     4500

cagtagtgcc tgtggtttag cccaccaatc ttgatgacta aaagtagctg atgcattgtg     4560

catatgatgc ttgagatggt ttttgcaaaa gcagaaatcg ctgcaaggta atcacaatag     4620

ataaaagtgg tattttaaac ctttgaaata aatggatgta actgtacctt ggtacagctt     4680

ttcacttgtt tagtttttaa acgttagtat aatctgaata aataaaatgt tgccaaattc     4740

aatgtagaaa gaatgtgaca acacaccttg ggtagttctg cttgtgtttt tgcatattgt     4800

aaaagcagtg tcacagctaa aaagaaagaa atcgtttcta acagtaaatt attgtgcttt     4860

agttgctagt ttgtactgag agttgacctc tccctgtgca gttttttgtt ctaaacttgt     4920

ataaataaca attgtgtaat gtgtctccct cctacattgt aacaattgct tcagcctacg     4980

ttataaataa agaaccacta gattaaaaaa                                      5010


<210>  46
<211>  755
<212>  PRT
<213>  homo sapiens

<400>  46

Met Glu Ala Val Ile Glu Lys Glu Cys Ser Ala Leu Gly Gly Leu Phe 
1               5                   10                  15      


Gln Thr Ile Ile Ser Asp Met Lys Gly Ser Tyr Pro Val Trp Glu Asp 
            20                  25                  30          


Phe Ile Asn Lys Ala Gly Lys Leu Gln Ser Gln Leu Arg Thr Thr Val 
        35                  40                  45              


Val Ala Ala Ala Ala Phe Leu Asp Ala Phe Gln Lys Val Ala Asp Met 
    50                  55                  60                  


Ala Thr Asn Thr Arg Gly Gly Thr Arg Glu Ile Gly Ser Ala Leu Thr 
65                  70                  75                  80  


Arg Met Cys Met Arg His Arg Ser Ile Glu Ala Lys Leu Arg Gln Phe 
                85                  90                  95      


Ser Ser Ala Leu Ile Asp Cys Leu Ile Asn Pro Leu Gln Glu Gln Met 
            100                 105                 110         


Glu Glu Trp Lys Lys Val Ala Asn Gln Leu Asp Lys Asp His Ala Lys 
        115                 120                 125             


Glu Tyr Lys Lys Ala Arg Gln Glu Ile Lys Lys Lys Ser Ser Asp Thr 
    130                 135                 140                 


Leu Lys Leu Gln Lys Lys Ala Lys Lys Gly Arg Gly Asp Ile Gln Pro 
145                 150                 155                 160 


Gln Leu Asp Ser Ala Leu Gln Asp Val Asn Asp Lys Tyr Leu Leu Leu 
                165                 170                 175     


Glu Glu Thr Glu Lys Gln Ala Val Arg Lys Ala Leu Ile Glu Glu Arg 
            180                 185                 190         


Gly Arg Phe Cys Thr Phe Ile Ser Met Leu Arg Pro Val Ile Glu Glu 
        195                 200                 205             


Glu Ile Ser Met Leu Gly Glu Ile Thr His Leu Gln Thr Ile Ser Glu 
    210                 215                 220                 


Asp Leu Lys Ser Leu Thr Met Asp Pro His Lys Leu Pro Ser Ser Ser 
225                 230                 235                 240 


Glu Gln Val Ile Leu Asp Leu Lys Gly Ser Asp Tyr Ser Trp Ser Tyr 
                245                 250                 255     


Gln Thr Pro Pro Ser Ser Pro Ser Thr Thr Met Ser Arg Lys Ser Ser 
            260                 265                 270         


Val Cys Ser Ser Leu Asn Ser Val Asn Ser Ser Asp Ser Arg Ser Ser 
        275                 280                 285             


Gly Ser His Ser His Ser Pro Ser Ser His Tyr Arg Tyr Arg Ser Ser 
    290                 295                 300                 


Asn Leu Ala Gln Gln Ala Pro Val Arg Leu Ser Ser Val Ser Ser His 
305                 310                 315                 320 


Asp Ser Gly Phe Ile Ser Gln Asp Ala Phe Gln Ser Lys Ser Pro Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Ala Pro Asn Gln Leu Ser Asn Gly Phe Ser His 
            340                 345                 350         


Tyr Ser Leu Ser Ser Glu Ser His Val Gly Pro Thr Gly Ala Gly Leu 
        355                 360                 365             


Phe Pro His Cys Leu Pro Ala Ser Arg Leu Leu Pro Arg Val Thr Ser 
    370                 375                 380                 


Val His Leu Pro Asp Tyr Ala His Tyr Tyr Thr Ile Gly Pro Gly Met 
385                 390                 395                 400 


Phe Pro Ser Ser Gln Ile Pro Ser Trp Lys Asp Trp Ala Lys Pro Gly 
                405                 410                 415     


Pro Tyr Asp Gln Pro Leu Val Asn Thr Leu Gln Arg Arg Lys Glu Lys 
            420                 425                 430         


Arg Glu Pro Asp Pro Asn Gly Gly Gly Pro Thr Thr Ala Ser Gly Pro 
        435                 440                 445             


Pro Ala Ala Ala Glu Glu Ala Gln Arg Pro Arg Ser Met Thr Val Ser 
    450                 455                 460                 


Ala Ala Thr Arg Pro Gly Glu Glu Met Glu Ala Cys Glu Glu Leu Ala 
465                 470                 475                 480 


Leu Ala Leu Ser Arg Gly Leu Gln Leu Asp Thr Gln Arg Ser Ser Arg 
                485                 490                 495     


Asp Ser Leu Gln Cys Ser Ser Gly Tyr Ser Thr Gln Thr Thr Thr Pro 
            500                 505                 510         


Cys Cys Ser Glu Asp Thr Ile Pro Ser Gln Val Ser Asp Tyr Asp Tyr 
        515                 520                 525             


Phe Ser Val Ser Gly Asp Gln Glu Ala Asp Gln Gln Glu Phe Asp Lys 
    530                 535                 540                 


Ser Ser Thr Ile Pro Arg Asn Ser Asp Ile Ser Gln Ser Tyr Arg Arg 
545                 550                 555                 560 


Met Phe Gln Ala Lys Arg Pro Ala Ser Thr Ala Gly Leu Pro Thr Thr 
                565                 570                 575     


Leu Gly Pro Ala Met Val Thr Pro Gly Val Ala Thr Ile Arg Arg Thr 
            580                 585                 590         


Pro Ser Thr Lys Pro Ser Val Arg Arg Gly Thr Ile Gly Ala Gly Pro 
        595                 600                 605             


Ile Pro Ile Lys Thr Pro Val Ile Pro Val Lys Thr Pro Thr Val Pro 
    610                 615                 620                 


Asp Leu Pro Gly Val Leu Pro Ala Pro Pro Asp Gly Pro Glu Glu Arg 
625                 630                 635                 640 


Gly Glu His Ser Pro Glu Ser Pro Ser Val Gly Glu Gly Pro Gln Gly 
                645                 650                 655     


Val Thr Ser Met Pro Ser Ser Met Trp Ser Gly Gln Ala Ser Val Asn 
            660                 665                 670         


Pro Pro Leu Pro Gly Pro Lys Pro Ser Ile Pro Glu Glu His Arg Gln 
        675                 680                 685             


Ala Ile Pro Glu Ser Glu Ala Glu Asp Gln Glu Arg Glu Pro Pro Ser 
    690                 695                 700                 


Ala Thr Val Ser Pro Gly Gln Ile Pro Glu Ser Asp Pro Ala Asp Leu 
705                 710                 715                 720 


Ser Pro Arg Asp Thr Pro Gln Gly Glu Asp Met Leu Asn Ala Ile Arg 
                725                 730                 735     


Arg Gly Val Lys Leu Lys Lys Thr Thr Thr Asn Asp Arg Ser Ala Pro 
            740                 745                 750         


Arg Phe Ser 
        755 


<210>  47
<211>  2672
<212>  DNA
<213>  homo sapiens

<400>  47
cttccagaga gcaatatggc tggttcccca acatgcctca ccctcatcta tatcctttgg       60

cagctcacag ggtcagcagc ctctggaccc gtgaaagagc tggtcggttc cgttggtggg      120

gccgtgactt tccccctgaa gtccaaagta aagcaagttg actctattgt ctggaccttc      180

aacacaaccc ctcttgtcac catacagcca gaagggggca ctatcatagt gacccaaaat      240

cgtaataggg agagagtaga cttcccagat ggaggctact ccctgaagct cagcaaactg      300

aagaagaatg actcagggat ctactatgtg gggatataca gctcatcact ccagcagccc      360

tccacccagg agtacgtgct gcatgtctac gagcacctgt caaagcctaa agtcaccatg      420

ggtctgcaga gcaataagaa tggcacctgt gtgaccaatc tgacatgctg catggaacat      480

ggggaagagg atgtgattta tacctggaag gccctggggc aagcagccaa tgagtcccat      540

aatgggtcca tcctccccat ctcctggaga tggggagaaa gtgatatgac cttcatctgc      600

gttgccagga accctgtcag cagaaacttc tcaagcccca tccttgccag gaagctctgt      660

gaaggtgctg ctgatgaccc agattcctcc atggtcctcc tgtgtctcct gttggtgccc      720

ctcctgctca gtctctttgt actggggcta tttctttggt ttctgaagag agagagacaa      780

gaagagtaca ttgaagagaa gaagagagtg gacatttgtc gggaaactcc taacatatgc      840

ccccattctg gagagaacac agagtacgac acaatccctc acactaatag aacaatccta      900

aaggaagatc cagcaaatac ggtttactcc actgtggaaa taccgaaaaa gatggaaaat      960

ccccactcac tgctcacgat gccagacaca ccaaggctat ttgcctatga gaatgttatc     1020

tagacagcag tgcactcccc taagtctctg ctcaaaaaaa aaacaattct cggcccaaag     1080

aaaacaatca gaagaattca ctgatttgac tagaaacatc aaggaagaat gaagaacgtt     1140

gacttttttc caggataaat tatctctgat gcttctttag atttaagagt tcataattcc     1200

atccactgct gagaaatctc ctcaaaccca gaaggtttaa tcacttcatc ccaaaaatgg     1260

gattgtgaat gtcagcaaac cataaaaaaa gtgcttagaa gtattcctat agaaatgtaa     1320

atgcaaggtc acacatatta atgacagcct gttgtattaa tgatggctcc aggtcagtgt     1380

ctggagtttc attccatccc agggcttgga tgtaaggatt ataccaagag tcttgctacc     1440

aggagggcaa gaagaccaaa acagacagac aagtccagca gaagcagatg cacctgacaa     1500

aaatggatgt attaattggc tctataaact atgtgcccag cactatgctg agcttacact     1560

aattggtcag acgtgctgtc tgccctcatg aaattggctc caaatgaatg aactactttc     1620

atgagcagtt gtagcaggcc tgaccacaga ttcccagagg gccaggtgtg gatccacagg     1680

acttgaaggt caaagttcac aaagatgaag aatcagggta gctgaccatg tttggcagat     1740

actataatgg agacacagaa gtgtgcatgg cccaaggaca aggacctcca gccaggcttc     1800

atttatgcac ttgtgctgca aaagaaaagt ctaggtttta aggctgtgcc agaacccatc     1860

ccaataaaga gaccgagtct gaagtcacat tgtaaatcta gtgtaggaga cttggagtca     1920

ggcagtgaga ctggtggggc acggggggca gtgggtactt gtaaaccttt aaagatggtt     1980

aattcattca atagatattt attaagaacc tatgcggccc ggcatggtgg ctcacacctg     2040

taatcccagc actttgggag gccaaggtgg gtgggtcatc tgaggtcagg agttcaagac     2100

cagcctggcc aacatggtga aaccccatct ctactaaaga tacaaaaatt tgctgagcgt     2160

ggtggtgtgc acctgtaatc ccagctactc gagaggccaa ggcatgagaa tcgcttgaac     2220

ctgggaggtg gaggttgcag tgagctgaga tggcaccact gcactccggc ctaggcaacg     2280

agagcaaaac tccaatacaa acaaacaaac aaacacctgt gctaggtcag tctggcacgt     2340

aagatgaaca tccctaccaa cacagagctc accatctctt atacttaagt gaaaaacatg     2400

gggaagggga aaggggaatg gctgcttttg atatgttccc tgacacatat cttgaatgga     2460

gacctcccta ccaagtgatg aaagtgttga aaaacttaat aacaaatgct tgttgggcaa     2520

gaatgggatt gaggattatc ttctctcaga aaggcattgt gaaggaattg agccagatct     2580

ctctccctac tgcaaaaccc tattgtagta aaaaagtctt ctttactatc ttaataaaac     2640

agatattgtg agattcaaaa aaaaaaaaaa aa                                   2672


<210>  48
<211>  335
<212>  PRT
<213>  homo sapiens

<400>  48

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  49
<211>  2008
<212>  DNA
<213>  homo sapiens

<400>  49
ctcccgtccc ccttccgccg cgtgggtgcc atggcaacgg agagagacgg caacctgggt       60

tccggaagcc ggagagctgg agctttgaag ccaccccggt caaaggatgc tgagtccgga      120

gcgcctagcc ctaccggact acgagtatct ggctcagcga catgtcctca cctacatgga      180

ggatgcagtg tgccagctgc tagaaaacag ggaagatatt agccaatatg gaattgccag      240

gttcttcact gaatatttta acagtgtatg ccagggaaca cacattctct ttcgagaatt      300

cagcttcgtc caagccaccc cccacaatag ggtatcattt ttacgggcct tctggagatg      360

cttccgaact gtgggcaaaa atggcgattt gctgaccatg aaagaatatc actgtttgct      420

gcaattactg tgtcctgatt tcccgctgga gctcactcag aaagcagcca ggattgtgct      480

catggacgat gccatggact gcttgatgtc tttttcagat ttcctctttg ccttccagat      540

ccagttttac tactcagaat tcctggacag tgtggctgcc atctatgagg acctgctgtc      600

aggcaagaac cccaacacag tgattgtgcc gacgtcgtcc agtgggcagc accgccaacg      660

acctgccttg ggcggggccg gcacgctgga gggcgtggag gcgtcgctgt tctaccagtg      720

tctggaaaac ctgtgtgatc ggcacaagta cagctgccca cccccagcac ttgtcaaaga      780

ggccctcagc aatgttcaga gactgacctt ctatggattc ctcatggctc tctcaaagca      840

ccgtggaatc aaccaagccc tcggagcttt gcctgacaag ggggatctga tgcacgaccc      900

agcaatggat gaagagctgg aacggctgta agtgtcaagt gggaggatac tgcccccttg      960

tgggggccag acgggtcgga cacggctgtg ccccatctgg ggccaacacc acttgtctgt     1020

aacatcccac atctgccagg gaagggtctg ggggccagtg gaggcctgag gtgtccctcc     1080

ctctgagtcc tttgggggct gcagcccagg ggtttaccct agtgttaaga gtgggcatgg     1140

aggccctgct ctctgtacag gaggcctctc gctgccctcc aggcttcttc ccttcttcag     1200

gctggcccag gtcccaggcc tggtcaactc ggtcacagcc agtccagagg ccagttgcct     1260

gccttcccgg acccctcccc gggttggctc tccctggaga cctctccatc attcccgaaa     1320

agtggatgga gagagtgatg gctccactga agagacagac gagtcggaga cttgaggagt     1380

ccaaagggtc ctgcccacag cgccctgtac ctgctcccac ccagcccttg gtgtgcccac     1440

ccagcctcct ctccagcacc ttgctgtgct gccctctgct gctgacaagg tgaataacag     1500

ccccaagacc agccagaggg gctctgatga tcagcccagc cagtggcccc ggaaggtgaa     1560

tggcctgctc tccctggccc tatcagcctg tgaacttcac ttaggcccca agctgacaga     1620

ctgtgctgag gccaccttgt cacgccgtag cctgttagtc ctcctaacct cttaagagca     1680

gtctcttctg agccagcctc tgcgggtccc ccaataaggt tcatctcctc acagcaactc     1740

cattaagggg gagaacccga atagccacgc agggccttgc accatcaagg gtgacacctg     1800

cgacgcaagt accaggagga cataaccgct gtggcctgtt ggagaacagc cagtagcctt     1860

ggtaatatga agggtgggcc agaagatgat ttcacttgca aaaactgctt caagtcttga     1920

cccctttgtg tctaatagct aaacaaacat gtgaaacgaa taaaaagtcc ctcatgtctg     1980

gtaaaaaaaa aaaaaaaaaa aaaaaaaa                                        2008


<210>  50
<211>  274
<212>  PRT
<213>  homo sapiens

<400>  50

Met Leu Ser Pro Glu Arg Leu Ala Leu Pro Asp Tyr Glu Tyr Leu Ala 
1               5                   10                  15      


Gln Arg His Val Leu Thr Tyr Met Glu Asp Ala Val Cys Gln Leu Leu 
            20                  25                  30          


Glu Asn Arg Glu Asp Ile Ser Gln Tyr Gly Ile Ala Arg Phe Phe Thr 
        35                  40                  45              


Glu Tyr Phe Asn Ser Val Cys Gln Gly Thr His Ile Leu Phe Arg Glu 
    50                  55                  60                  


Phe Ser Phe Val Gln Ala Thr Pro His Asn Arg Val Ser Phe Leu Arg 
65                  70                  75                  80  


Ala Phe Trp Arg Cys Phe Arg Thr Val Gly Lys Asn Gly Asp Leu Leu 
                85                  90                  95      


Thr Met Lys Glu Tyr His Cys Leu Leu Gln Leu Leu Cys Pro Asp Phe 
            100                 105                 110         


Pro Leu Glu Leu Thr Gln Lys Ala Ala Arg Ile Val Leu Met Asp Asp 
        115                 120                 125             


Ala Met Asp Cys Leu Met Ser Phe Ser Asp Phe Leu Phe Ala Phe Gln 
    130                 135                 140                 


Ile Gln Phe Tyr Tyr Ser Glu Phe Leu Asp Ser Val Ala Ala Ile Tyr 
145                 150                 155                 160 


Glu Asp Leu Leu Ser Gly Lys Asn Pro Asn Thr Val Ile Val Pro Thr 
                165                 170                 175     


Ser Ser Ser Gly Gln His Arg Gln Arg Pro Ala Leu Gly Gly Ala Gly 
            180                 185                 190         


Thr Leu Glu Gly Val Glu Ala Ser Leu Phe Tyr Gln Cys Leu Glu Asn 
        195                 200                 205             


Leu Cys Asp Arg His Lys Tyr Ser Cys Pro Pro Pro Ala Leu Val Lys 
    210                 215                 220                 


Glu Ala Leu Ser Asn Val Gln Arg Leu Thr Phe Tyr Gly Phe Leu Met 
225                 230                 235                 240 


Ala Leu Ser Lys His Arg Gly Ile Asn Gln Ala Leu Gly Ala Leu Pro 
                245                 250                 255     


Asp Lys Gly Asp Leu Met His Asp Pro Ala Met Asp Glu Glu Leu Glu 
            260                 265                 270         


Arg Leu 
        


<210>  51
<211>  1272
<212>  DNA
<213>  homo sapiens

<400>  51
ccaaagaaag caaggggacc aaggccggga ctgctggggt gaaggtccgg gaggctgagt       60

aaggggacgg aagggcacag gccatggaaa ggaatgacat catcaacttc aaggctttgg      120

agaaagagct gcaggctgca ctcactgctg atgagaagta caaacgggag aatgctgcca      180

agttacgggc agtggaacag agggtggctt cctatgagga gttcaggggt attgtccttg      240

catcacatct gaagccactg gagcggaagg ataagatggg aggaaagaga actgtgccct      300

ggaactgtca cactattcag ggaaggacct tccaggatgt ggccactgaa atctccccgg      360

agaaagcccc cctccagccc gagacgtctg ctgacttcta tcgtgattgg cgacgacact      420

tgccaagtgg gccagagcgc taccaggctc tactgcagct tgggggtcca aggctcggct      480

gcctcttcca gacagatgtg ggatttggac ttcttgggga gctgctggtg gcactggctg      540

atcacgtggg gccggctgac cgggcagcgg tgctggggat cctatgcagc ctggcgagca      600

ctgggcgctt caccctgaac ctaagcctgc tgagccgggc agagagagag agctgcaagg      660

gcttgtttca gaagctgcaa gccatgggca accccagatc cgtgaaggag gggctcagct      720

gggaggagca gggtctggag gagcagtctg gtgggctcca ggaggaggag aggctcctgc      780

aggagctgct ggagctgtac caggttgact gatgcagcaa gctaccctca gaggtcccag      840

tggtcactgg aggcagtttt ttggttgttg tcttgggggt tctgcaggac cataataaga      900

aacccacacc tggttccctt ctcaacttgg aattttcaga gcaaaaacag gaatcaagtc      960

ttccccactt ctccagtccc tcagtgtctc gctgttttga actgtgtgta tccatggaca     1020

gtcaagagct caggaagttg agagcggttt tgtttcccac ccttagagtc tgccaagcct     1080

ctagcccact ggccttgaga gatgagtgtg tgcccaacca aatgctggct ataccagtta     1140

cagcctccac tcataaaagg gaaaaagcaa aatctttatg gtaaacaaac actgatctcc     1200

acagctctta acaagaatgt ttatagcccc aaaccaatga atggacatgt aatcaaaaaa     1260

aaaaaaaaaa aa                                                         1272


<210>  52
<211>  242
<212>  PRT
<213>  homo sapiens

<400>  52

Met Glu Arg Asn Asp Ile Ile Asn Phe Lys Ala Leu Glu Lys Glu Leu 
1               5                   10                  15      


Gln Ala Ala Leu Thr Ala Asp Glu Lys Tyr Lys Arg Glu Asn Ala Ala 
            20                  25                  30          


Lys Leu Arg Ala Val Glu Gln Arg Val Ala Ser Tyr Glu Glu Phe Arg 
        35                  40                  45              


Gly Ile Val Leu Ala Ser His Leu Lys Pro Leu Glu Arg Lys Asp Lys 
    50                  55                  60                  


Met Gly Gly Lys Arg Thr Val Pro Trp Asn Cys His Thr Ile Gln Gly 
65                  70                  75                  80  


Arg Thr Phe Gln Asp Val Ala Thr Glu Ile Ser Pro Glu Lys Ala Pro 
                85                  90                  95      


Leu Gln Pro Glu Thr Ser Ala Asp Phe Tyr Arg Asp Trp Arg Arg His 
            100                 105                 110         


Leu Pro Ser Gly Pro Glu Arg Tyr Gln Ala Leu Leu Gln Leu Gly Gly 
        115                 120                 125             


Pro Arg Leu Gly Cys Leu Phe Gln Thr Asp Val Gly Phe Gly Leu Leu 
    130                 135                 140                 


Gly Glu Leu Leu Val Ala Leu Ala Asp His Val Gly Pro Ala Asp Arg 
145                 150                 155                 160 


Ala Ala Val Leu Gly Ile Leu Cys Ser Leu Ala Ser Thr Gly Arg Phe 
                165                 170                 175     


Thr Leu Asn Leu Ser Leu Leu Ser Arg Ala Glu Arg Glu Ser Cys Lys 
            180                 185                 190         


Gly Leu Phe Gln Lys Leu Gln Ala Met Gly Asn Pro Arg Ser Val Lys 
        195                 200                 205             


Glu Gly Leu Ser Trp Glu Glu Gln Gly Leu Glu Glu Gln Ser Gly Gly 
    210                 215                 220                 


Leu Gln Glu Glu Glu Arg Leu Leu Gln Glu Leu Leu Glu Leu Tyr Gln 
225                 230                 235                 240 


Val Asp 
        


<210>  53
<211>  3672
<212>  DNA
<213>  homo sapiens

<400>  53
agtaaaccac agccttcagc atgctctgct caggcggcag cagtggcttt ttggaggtgt       60

ctcggccatg acacacattt gacatgccct ccctcaacct acttatagac tatttttctt      120

gctctgcagc atggaccaaa gagaaattct gcagaagttc ctggatgagg cccaaagcaa      180

gaaaattact aaagaggagt ttgccaatga atttctgaag ctgaaaaggc aatctaccaa      240

gtacaaggca gacaaaacct atcctacaac tgtggctgag aagcccaaga atatcaagaa      300

aaacagatat aaggatattt tgccctatga ttatagccgg gtagaactat ccctgataac      360

ctctgatgag gattccagct acatcaatgc caacttcatt aagggagttt atggacccaa      420

ggcttatatt gccacccagg gtcctttatc tacaaccctc ctggacttct ggaggatgat      480

ttgggaatat agtgtcctta tcattgttat ggcatgcatg gagtatgaaa tgggaaagaa      540

aaagtgtgag cgctactggg ctgagccagg agagatgcag ctggaatttg gccctttctc      600

tgtatcctgt gaagctgaaa aaaggaaatc tgattatata atcaggactc taaaagttaa      660

gttcaatagt gaaactcgaa ctatctacca gtttcattac aagaattggc cagaccatga      720

tgtaccttca tctatagacc ctattcttga gctcatctgg gatgtacgtt gttaccaaga      780

ggatgacagt gttcccatat gcattcactg cagtgctggc tgtggaagga ctggtgttat      840

ttgtgctatt gattatacat ggatgttgct aaaagatggg ataattcctg agaacttcag      900

tgttttcagt ttgatccggg aaatgcggac acagaggcct tcattagttc aaacgcagga      960

acaatatgaa ctggtctaca atgctgtatt agaactattt aagagacaga tggatgttat     1020

cagagataaa cattctggaa cagagagtca agcaaagcat tgtattcctg agaaaaatca     1080

cactctccaa gcagactctt attctcctaa tttaccaaaa agtaccacaa aagcagcaaa     1140

aatgatgaac caacaaagga caaaaatgga aatcaaagaa tcttcttcct ttgactttag     1200

gacttctgaa ataagtgcaa aagaagagct agttttgcac cctgctaaat caagcacttc     1260

ttttgacttt ctggagctaa attacagttt tgacaaaaat gctgacacaa ccatgaaatg     1320

gcagacaaag gcatttccaa tagttgggga gcctcttcag aagcatcaaa gtttggattt     1380

gggctctctt ttgtttgagg gatgttctaa ttctaaacct gtaaatgcag caggaagata     1440

ttttaattca aaggtgccaa taacacggac caaatcaact ccttttgaat tgatacagca     1500

gagagaaacc aaggaggtgg acagcaagga aaacttttct tatttggaat ctcaaccaca     1560

tgattcttgt tttgtagaga tgcaggctca aaaagtaatg catgtttctt cagcagaact     1620

gaattattca ctgccatatg actctaaaca ccaaatacgt aatgcctcta atgtaaagca     1680

ccatgactct agtgctcttg gtgtatattc ttacatacct ttagtggaaa atccttattt     1740

ttcatcatgg cctccaagtg gtaccagttc taagatgtct cttgatttac ctgagaagca     1800

agatggaact gtttttcctt cttctctgtt gccaacatcc tctacatccc tcttctctta     1860

ttacaattca catgattctt tatcactgaa ttctccaacc aatatttcct cactattgaa     1920

ccaggagtca gctgtactag caactgctcc aaggatagat gatgaaatcc cccctccact     1980

tcctgtacgg acacctgaat catttattgt ggttgaggaa gctggagaat tctcaccaaa     2040

tgttcccaaa tccttatcct cagctgtgaa ggtaaaaatt ggaacatcac tggaatgggg     2100

tggaacatct gaaccaaaga aatttgatga ctctgtgata cttagaccaa gcaagagtgt     2160

aaaactccga agtcctaaat cagaactaca tcaagatcgt tcttctcccc cacctcctct     2220

cccagaaaga actctagagt ccttctttct tgccgatgaa gattgtatgc aggcccaatc     2280

tatagaaaca tattctacta gctatcctga caccatggaa aattcaacat cttcaaaaca     2340

gacactgaag actcctggaa aaagtttcac aaggagtaag agtttgaaaa ttttgcgaaa     2400

catgaaaaag agtatctgta attcttgccc accaaacaag cctgcagaat ctgttcagtc     2460

aaataactcc agctcatttc tgaattttgg ttttgcaaac cgtttttcaa aacccaaagg     2520

accaaggaat ccaccaccaa cttggaatat ttaataaaac tccagattta taataatatg     2580

ggctgcaagt acacctgcaa ataaaactac tagaatactg ctagttaaaa taagtgctct     2640

atatgcataa tatcaaatat gaagatatgc taatgtgtta atagctttta aaagaaaagc     2700

aaaatgccaa taagtgccag ttttgcattt tcatatcatt tgcattgagt tgaaaactgc     2760

aaataaaagt ttgtcacttg agcttatgta cagaatgcta tatgagaaac acttttagaa     2820

tggatttatt tttcattttt gccagttatt tttattttct tttacttttc tacataaaca     2880

taaacttcaa aaggtttgta agatttggat ctcaactaat ttctacattg ccagaatata     2940

ctataaaaag ttaaaaaaaa aacttacttt gtgggttgca atacaaactg ctcttgacaa     3000

tgactattcc ctgacagtta tttttgccta aatggagtat accttgtaaa tcttcccaaa     3060

tgttgtggaa aactggaata ttaagaaaat gagaaattat atttattaga ataaaatgtg     3120

caaataatga caattatttg aatgtaacaa ggaattcaac tgaaatcctg ataagtttta     3180

accaaagtca ttaaattacc aattctagaa aagtaatcaa tgaaatataa tagctatctt     3240

ttggtagcaa aagatataaa ttgtatatgt ttatacagga tctttcagat catgtgcaat     3300

ttttatctaa ccaatcagaa atactagttt aaaatgaatt tctatatgaa tatggatctg     3360

ccataagaaa atctagttca actctaattt tatgtagtaa ataaattggc aggtaattgt     3420

ttttacaaag aatccacctg acttccccta atgcattaaa aatattttta tttaaataac     3480

tttatttata acttttagaa acatgtagta ttgtttaaac atcatttgtt cttcagtatt     3540

tttcatttgg aagtccaata gggcaaattg aatgaagtat tattatctgt ctcttgtagt     3600

acaatgtatc caacagacac tcaataaact ttttggttgt taaactgaaa aaaaaaaaaa     3660

aaaaaaaaaa aa                                                         3672


<210>  54
<211>  807
<212>  PRT
<213>  homo sapiens

<400>  54

Met Asp Gln Arg Glu Ile Leu Gln Lys Phe Leu Asp Glu Ala Gln Ser 
1               5                   10                  15      


Lys Lys Ile Thr Lys Glu Glu Phe Ala Asn Glu Phe Leu Lys Leu Lys 
            20                  25                  30          


Arg Gln Ser Thr Lys Tyr Lys Ala Asp Lys Thr Tyr Pro Thr Thr Val 
        35                  40                  45              


Ala Glu Lys Pro Lys Asn Ile Lys Lys Asn Arg Tyr Lys Asp Ile Leu 
    50                  55                  60                  


Pro Tyr Asp Tyr Ser Arg Val Glu Leu Ser Leu Ile Thr Ser Asp Glu 
65                  70                  75                  80  


Asp Ser Ser Tyr Ile Asn Ala Asn Phe Ile Lys Gly Val Tyr Gly Pro 
                85                  90                  95      


Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser Thr Thr Leu Leu Asp 
            100                 105                 110         


Phe Trp Arg Met Ile Trp Glu Tyr Ser Val Leu Ile Ile Val Met Ala 
        115                 120                 125             


Cys Met Glu Tyr Glu Met Gly Lys Lys Lys Cys Glu Arg Tyr Trp Ala 
    130                 135                 140                 


Glu Pro Gly Glu Met Gln Leu Glu Phe Gly Pro Phe Ser Val Ser Cys 
145                 150                 155                 160 


Glu Ala Glu Lys Arg Lys Ser Asp Tyr Ile Ile Arg Thr Leu Lys Val 
                165                 170                 175     


Lys Phe Asn Ser Glu Thr Arg Thr Ile Tyr Gln Phe His Tyr Lys Asn 
            180                 185                 190         


Trp Pro Asp His Asp Val Pro Ser Ser Ile Asp Pro Ile Leu Glu Leu 
        195                 200                 205             


Ile Trp Asp Val Arg Cys Tyr Gln Glu Asp Asp Ser Val Pro Ile Cys 
    210                 215                 220                 


Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Val Ile Cys Ala Ile 
225                 230                 235                 240 


Asp Tyr Thr Trp Met Leu Leu Lys Asp Gly Ile Ile Pro Glu Asn Phe 
                245                 250                 255     


Ser Val Phe Ser Leu Ile Arg Glu Met Arg Thr Gln Arg Pro Ser Leu 
            260                 265                 270         


Val Gln Thr Gln Glu Gln Tyr Glu Leu Val Tyr Asn Ala Val Leu Glu 
        275                 280                 285             


Leu Phe Lys Arg Gln Met Asp Val Ile Arg Asp Lys His Ser Gly Thr 
    290                 295                 300                 


Glu Ser Gln Ala Lys His Cys Ile Pro Glu Lys Asn His Thr Leu Gln 
305                 310                 315                 320 


Ala Asp Ser Tyr Ser Pro Asn Leu Pro Lys Ser Thr Thr Lys Ala Ala 
                325                 330                 335     


Lys Met Met Asn Gln Gln Arg Thr Lys Met Glu Ile Lys Glu Ser Ser 
            340                 345                 350         


Ser Phe Asp Phe Arg Thr Ser Glu Ile Ser Ala Lys Glu Glu Leu Val 
        355                 360                 365             


Leu His Pro Ala Lys Ser Ser Thr Ser Phe Asp Phe Leu Glu Leu Asn 
    370                 375                 380                 


Tyr Ser Phe Asp Lys Asn Ala Asp Thr Thr Met Lys Trp Gln Thr Lys 
385                 390                 395                 400 


Ala Phe Pro Ile Val Gly Glu Pro Leu Gln Lys His Gln Ser Leu Asp 
                405                 410                 415     


Leu Gly Ser Leu Leu Phe Glu Gly Cys Ser Asn Ser Lys Pro Val Asn 
            420                 425                 430         


Ala Ala Gly Arg Tyr Phe Asn Ser Lys Val Pro Ile Thr Arg Thr Lys 
        435                 440                 445             


Ser Thr Pro Phe Glu Leu Ile Gln Gln Arg Glu Thr Lys Glu Val Asp 
    450                 455                 460                 


Ser Lys Glu Asn Phe Ser Tyr Leu Glu Ser Gln Pro His Asp Ser Cys 
465                 470                 475                 480 


Phe Val Glu Met Gln Ala Gln Lys Val Met His Val Ser Ser Ala Glu 
                485                 490                 495     


Leu Asn Tyr Ser Leu Pro Tyr Asp Ser Lys His Gln Ile Arg Asn Ala 
            500                 505                 510         


Ser Asn Val Lys His His Asp Ser Ser Ala Leu Gly Val Tyr Ser Tyr 
        515                 520                 525             


Ile Pro Leu Val Glu Asn Pro Tyr Phe Ser Ser Trp Pro Pro Ser Gly 
    530                 535                 540                 


Thr Ser Ser Lys Met Ser Leu Asp Leu Pro Glu Lys Gln Asp Gly Thr 
545                 550                 555                 560 


Val Phe Pro Ser Ser Leu Leu Pro Thr Ser Ser Thr Ser Leu Phe Ser 
                565                 570                 575     


Tyr Tyr Asn Ser His Asp Ser Leu Ser Leu Asn Ser Pro Thr Asn Ile 
            580                 585                 590         


Ser Ser Leu Leu Asn Gln Glu Ser Ala Val Leu Ala Thr Ala Pro Arg 
        595                 600                 605             


Ile Asp Asp Glu Ile Pro Pro Pro Leu Pro Val Arg Thr Pro Glu Ser 
    610                 615                 620                 


Phe Ile Val Val Glu Glu Ala Gly Glu Phe Ser Pro Asn Val Pro Lys 
625                 630                 635                 640 


Ser Leu Ser Ser Ala Val Lys Val Lys Ile Gly Thr Ser Leu Glu Trp 
                645                 650                 655     


Gly Gly Thr Ser Glu Pro Lys Lys Phe Asp Asp Ser Val Ile Leu Arg 
            660                 665                 670         


Pro Ser Lys Ser Val Lys Leu Arg Ser Pro Lys Ser Glu Leu His Gln 
        675                 680                 685             


Asp Arg Ser Ser Pro Pro Pro Pro Leu Pro Glu Arg Thr Leu Glu Ser 
    690                 695                 700                 


Phe Phe Leu Ala Asp Glu Asp Cys Met Gln Ala Gln Ser Ile Glu Thr 
705                 710                 715                 720 


Tyr Ser Thr Ser Tyr Pro Asp Thr Met Glu Asn Ser Thr Ser Ser Lys 
                725                 730                 735     


Gln Thr Leu Lys Thr Pro Gly Lys Ser Phe Thr Arg Ser Lys Ser Leu 
            740                 745                 750         


Lys Ile Leu Arg Asn Met Lys Lys Ser Ile Cys Asn Ser Cys Pro Pro 
        755                 760                 765             


Asn Lys Pro Ala Glu Ser Val Gln Ser Asn Asn Ser Ser Ser Phe Leu 
    770                 775                 780                 


Asn Phe Gly Phe Ala Asn Arg Phe Ser Lys Pro Lys Gly Pro Arg Asn 
785                 790                 795                 800 


Pro Pro Pro Thr Trp Asn Ile 
                805         


<210>  55
<211>  2234
<212>  DNA
<213>  homo sapiens

<400>  55
aactggctcc gattggctgt ggtacagcag gtgccgcgtc cggattgatc aaagccaggt       60

gggcggggct gtcgcccagg gtgactctcc cgggaggcgc gtgcccaggc tcagtagcat      120

tggggctggc gcgcgcggcg aatctcaacg ctgcgccgtc tgcgggcgct tccgggccac      180

cagtttctct gctttccacc ctggcgcccc ccagccctgg ctccccagct gcgctgcccc      240

gggcgtccac gccctgcggg cttagcgggt tcagtgggct caatctgcgc agcgccacct      300

ccatgttgac caagcctcta caggggcctc ccgcgccccc cgggaccccc acgccgccgc      360

caggaggcaa ggatcgggaa gcgttcgagg ccgagtatcg actcggcccc ctcctgggta      420

aggggggctt tggcaccgtc ttcgcaggac accgcctcac agatcgactc caggtggcca      480

tcaaagtgat tccccggaat cgtgtgctgg gctggtcccc cttgtcagac tcagtcacat      540

gcccactcga agtcgcactg ctatggaaag tgggtgcagg tggtgggcac cctggcgtga      600

tccgcctgct tgactggttt gagacacagg agggcttcat gctggtcctc gagcggcctt      660

tgcccgccca ggatctcttt gactatatca cagagaaggg cccactgggt gaaggcccaa      720

gccgctgctt ctttggccaa gtagtggcag ccatccagca ctgccattcc cgtggagttg      780

tccatcgtga catcaaggat gagaacatcc tgatagacct acgccgtggc tgtgccaaac      840

tcattgattt tggttctggt gccctgcttc atgatgaacc ctacactgac tttgatggga      900

caagggtgta cagcccccca gagtggatct ctcgacacca gtaccatgca ctcccggcca      960

ctgtctggtc actgggcatc ctcctctatg acatggtgtg tggggacatt ccctttgaga     1020

gggaccagga gattctggaa gctgagctcc acttcccagc ccatgtctcc ccagactgct     1080

gtgccctaat ccgccggtgc ctggccccca aaccttcttc ccgaccctca ctggaagaga     1140

tcctgctgga cccctggatg caaacaccag ccgaggatgt acccctcaac ccctccaaag     1200

gaggccctgc ccctttggcc tggtccttgc taccctaagc ctggcctggc ctggcctggc     1260

ccccaatggt cagaagagcc atcccatggc catgtcacag ggatagatgg acatttgttg     1320

acttggtttt acaggtcatt accagtcatt aaagtccagt attactaagg taagggattg     1380

aggatcaggg gttagaagac ataaaccaag tctgcccagt tcccttccca atcctacaaa     1440

ggagccttcc tcccagaacc tgtggtccct gattctggag ggggaacttc ttgcttctca     1500

ttttgctaag gaagtttatt ttggtgaagt tgttcccatt ctgagccccg ggactcttat     1560

tctgatgatg tgtcacccca cattggcacc tcctactacc accacacaaa cttagttcat     1620

atgctcttac ttgggcaagg gtgctttcct tccaataccc cagtagcttt tattttagta     1680

aagggaccct ttcccctagc ctagggtccc atattgggtc aagctgctta cctgcctcag     1740

cccaggattc tttattctgg gggaggtaat gccctgttgt taccccaagg cttctttttt     1800

tttttttttt ttttgggtga ggggacccta ctctgttatc ccaagtgctc ttattctggt     1860

gagaagaacc ttacttccat aatttgggaa ggaatggaag atggacacca ccggacacca     1920

ccagacacta ggatgggatg gatggttttt tgggggatgg gctaggggaa ataaggcttg     1980

ctgtttgttc tcctggggcg ctccctccaa cttttgcaga ttcttgcaac ctcctcctga     2040

gccgggattg tccaattact aaaatgtaaa taatcacgta ttgtggggag gggagttcca     2100

agtgtgccct cctctcttct cctgcctgga ttatttaaaa agccatgtgt ggaaacccac     2160

tatttaataa aagtaataga atcagaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaa                                                       2234


<210>  56
<211>  311
<212>  PRT
<213>  homo sapiens

<400>  56

Met Leu Thr Lys Pro Leu Gln Gly Pro Pro Ala Pro Pro Gly Thr Pro 
1               5                   10                  15      


Thr Pro Pro Pro Gly Gly Lys Asp Arg Glu Ala Phe Glu Ala Glu Tyr 
            20                  25                  30          


Arg Leu Gly Pro Leu Leu Gly Lys Gly Gly Phe Gly Thr Val Phe Ala 
        35                  40                  45              


Gly His Arg Leu Thr Asp Arg Leu Gln Val Ala Ile Lys Val Ile Pro 
    50                  55                  60                  


Arg Asn Arg Val Leu Gly Trp Ser Pro Leu Ser Asp Ser Val Thr Cys 
65                  70                  75                  80  


Pro Leu Glu Val Ala Leu Leu Trp Lys Val Gly Ala Gly Gly Gly His 
                85                  90                  95      


Pro Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Thr Gln Glu Gly Phe 
            100                 105                 110         


Met Leu Val Leu Glu Arg Pro Leu Pro Ala Gln Asp Leu Phe Asp Tyr 
        115                 120                 125             


Ile Thr Glu Lys Gly Pro Leu Gly Glu Gly Pro Ser Arg Cys Phe Phe 
    130                 135                 140                 


Gly Gln Val Val Ala Ala Ile Gln His Cys His Ser Arg Gly Val Val 
145                 150                 155                 160 


His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Arg Arg Gly 
                165                 170                 175     


Cys Ala Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu His Asp Glu 
            180                 185                 190         


Pro Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp 
        195                 200                 205             


Ile Ser Arg His Gln Tyr His Ala Leu Pro Ala Thr Val Trp Ser Leu 
    210                 215                 220                 


Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Arg 
225                 230                 235                 240 


Asp Gln Glu Ile Leu Glu Ala Glu Leu His Phe Pro Ala His Val Ser 
                245                 250                 255     


Pro Asp Cys Cys Ala Leu Ile Arg Arg Cys Leu Ala Pro Lys Pro Ser 
            260                 265                 270         


Ser Arg Pro Ser Leu Glu Glu Ile Leu Leu Asp Pro Trp Met Gln Thr 
        275                 280                 285             


Pro Ala Glu Asp Val Pro Leu Asn Pro Ser Lys Gly Gly Pro Ala Pro 
    290                 295                 300                 


Leu Ala Trp Ser Leu Leu Pro 
305                 310     


<210>  57
<211>  3316
<212>  DNA
<213>  homo sapiens

<400>  57
atctgctcct gtaagcccag agaggcccag ggacaacttc cactttattc tggatgtttt       60

cacttttggg acatcctgtt ctgagtcaag attcctcctt ctgaacatgg gactttccag      120

aaggaccaca gctcctcccg tgcatccact cggcctggga ggttctggat tttggctgtc      180

gagggagttt gcctgcctct ccagagaaag atggtcatga ggcccctgtg gagtctgctt      240

ctctgggaag ccctacttcc cattacagtt actggtgccc aagtgctgag caaagtcggg      300

ggctcggtgc tgctggtggc agcgcgtccc cctggcttcc aagtccgtga ggctatctgg      360

cgatctctct ggccttcaga agagctcctg gccacgtttt tccgaggctc cctggagact      420

ctgtaccatt cccgcttcct gggccgagcc cagctacaca gcaacctcag cctggagctc      480

gggccgctgg agtctggaga cagcggcaac ttctccgtgt tgatggtgga cacaaggggc      540

cagccctgga cccagaccct ccagctcaag gtgtacgatg cagtgcccag gcccgtggta      600

caagtgttca ttgctgtaga aagggatgct cagccctcca agacctgcca ggttttcttg      660

tcctgttggg cccccaacat cagcgaaata acctatagct ggcgacggga gacaaccatg      720

gactttggta tggaaccaca cagcctcttc acagacggac aggtgctgag catttccctg      780

ggaccaggag acagagatgt ggcctattcc tgcattgtct ccaaccctgt cagctgggac      840

ttggccacag tcacgccctg ggatagctgt catcatgagg cagcaccagg gaaggcctcc      900

tacaaagatg tgctgctggt ggtggtgcct gtctcgctgc tcctgatgct ggttactctc      960

ttctctgcct ggcactggtg cccctgctca gggaaaaaga aaaaggatgt ccatgctgac     1020

agagtgggtc cagagacaga gaaccccctt gtgcaggatc tgccataaag gacaatatga     1080

actgatgcct ggactatcag taaccccact gcacaggcac acgatgctct gggacataac     1140

tggtgcctgg aaatcaccat ggtcctcata tctcccatgg gaatcctgtc ctgcctcgaa     1200

ggagcagcct gggcagccat cacaccacga ggacaggaag caccagcacg tttcacacct     1260

cccccttccc tctcccatct tctcatatcc tggctcttct ctgggcaaga tgagccaagc     1320

agaacattcc atccaggaca ctggaagttc tccaggatcc agatccatgg ggacattaat     1380

agtccaaggc attccctccc ccaccactat tcataaagta ttaaccaact ggcaccaagg     1440

aattgcctcc agcctgagtc ctaggctcta aaagatatta catatttgaa ctaatagagg     1500

aactctgagt cacccatgcc agcatcagct tcagccccag accctgcagt ttgagatctg     1560

atgcttcctg agggccaagg cattgctgta agaaaaggtc tagaaatagg tgaaagtgag     1620

aggtggggga caggggtttc tctttctggc ctaaggactt tcaggtaatc agagttcatg     1680

ggccctcaaa ggtaaattgc agttgtagac accgaggatg gttgacaacc catggttgag     1740

atgggcaccg ttttgcagga aacaccatat taatagacat cctcaccatc tccatccgct     1800

ctcacgcctc ctgcaggatc tgggagtgag ggtggagagt ctttcctcac gctccagcac     1860

agtggccagg aaaagaaata ctgaatttgc cccagccaac aggacgttct tgcacaactt     1920

caagaaaagc agctcagctc aggatgagtc ttcctgcctg aaactgagag agtgaagaac     1980

cataaaacgc tatgcagaag gaacattatg gagagaaagg gtactgaggc actctagaat     2040

ctgccacatt cattttcaaa tgcaaatgca gaagacttac cttagttcaa ggggagggga     2100

caaagacccc acagcccaac agcaggactg tagaggtcac tctgactcca tcaaactttt     2160

tattgtggcc atcttaggaa aatacattct gcccctgaat gattctgtct agaaaagctc     2220

tggagtattg atcactactg gaaaaacact taaggagcta aacttacctt cggggattat     2280

tagctgataa ggttcacagt ttctctcacc caggtgtaac tggatttttt ctggggcctc     2340

aatccagtct tgataacagc gaggaaagag gtattgaaga aacaggggtg ggtttgaagt     2400

actattttcc cagggtggct tcaatctccc cacctaggat gtcagccctg tccaaggacc     2460

ttccctcttc tccccagttc ctgggcaatc acttcacctt ggacaaagga tcagcacagc     2520

tggcctccag atccacatca ccactcttcc actcgattgt tcccagatcc tccctgcctg     2580

gcctgctcag aggttccctg ttggtaacct ggctttatca aattctcatc cctttcccac     2640

acccacttct ctcctatcac cttcccccaa gattacctga acagggtcca tggccactca     2700

acctgtcagc ttgcaccatc cccacctgcc acctacagtc aggccacatg cctggtcact     2760

gaatcatgca aaactggcct cagtccctaa aaatgatgtg gaaaggaaag cccaggatct     2820

gacaatgagc cctggtggat ttgtggggaa aaaatacaca gcactcccca cctttctttc     2880

gttcatctcc agggccccac ctcagatcaa agcagctctg gatgagatgg gacctgcagc     2940

tctccctcca caaggtgact cttagcaacc tcatttcgac agtggtttgt agcgtggtgc     3000

accagggcct tgttgaacag atccacactg ctctaataaa gttcccatcc ttaatgactc     3060

acttgtcaac tagtggacta attaaccctc caccaaaaaa acacaaagtg cttctgtgag     3120

accaattttg tgctaatgag cattgagact gatgctttgt aagtcacacc acaacaaata     3180

ttgattgagg gcgctgcatg tgctgggtac atttcttggc acttgggaat cagtagtcaa     3240

gcgaaaccct tgcctttgag agtttatggt ctggataata taaataaaca agtaagcata     3300

aaaaaaaaaa aaaaaa                                                     3316


<210>  58
<211>  285
<212>  PRT
<213>  homo sapiens

<400>  58

Met Val Met Arg Pro Leu Trp Ser Leu Leu Leu Trp Glu Ala Leu Leu 
1               5                   10                  15      


Pro Ile Thr Val Thr Gly Ala Gln Val Leu Ser Lys Val Gly Gly Ser 
            20                  25                  30          


Val Leu Leu Val Ala Ala Arg Pro Pro Gly Phe Gln Val Arg Glu Ala 
        35                  40                  45              


Ile Trp Arg Ser Leu Trp Pro Ser Glu Glu Leu Leu Ala Thr Phe Phe 
    50                  55                  60                  


Arg Gly Ser Leu Glu Thr Leu Tyr His Ser Arg Phe Leu Gly Arg Ala 
65                  70                  75                  80  


Gln Leu His Ser Asn Leu Ser Leu Glu Leu Gly Pro Leu Glu Ser Gly 
                85                  90                  95      


Asp Ser Gly Asn Phe Ser Val Leu Met Val Asp Thr Arg Gly Gln Pro 
            100                 105                 110         


Trp Thr Gln Thr Leu Gln Leu Lys Val Tyr Asp Ala Val Pro Arg Pro 
        115                 120                 125             


Val Val Gln Val Phe Ile Ala Val Glu Arg Asp Ala Gln Pro Ser Lys 
    130                 135                 140                 


Thr Cys Gln Val Phe Leu Ser Cys Trp Ala Pro Asn Ile Ser Glu Ile 
145                 150                 155                 160 


Thr Tyr Ser Trp Arg Arg Glu Thr Thr Met Asp Phe Gly Met Glu Pro 
                165                 170                 175     


His Ser Leu Phe Thr Asp Gly Gln Val Leu Ser Ile Ser Leu Gly Pro 
            180                 185                 190         


Gly Asp Arg Asp Val Ala Tyr Ser Cys Ile Val Ser Asn Pro Val Ser 
        195                 200                 205             


Trp Asp Leu Ala Thr Val Thr Pro Trp Asp Ser Cys His His Glu Ala 
    210                 215                 220                 


Ala Pro Gly Lys Ala Ser Tyr Lys Asp Val Leu Leu Val Val Val Pro 
225                 230                 235                 240 


Val Ser Leu Leu Leu Met Leu Val Thr Leu Phe Ser Ala Trp His Trp 
                245                 250                 255     


Cys Pro Cys Ser Gly Lys Lys Lys Lys Asp Val His Ala Asp Arg Val 
            260                 265                 270         


Gly Pro Glu Thr Glu Asn Pro Leu Val Gln Asp Leu Pro 
        275                 280                 285 


<210>  59
<211>  5769
<212>  DNA
<213>  homo sapiens

<400>  59
gagggaggag agttcacttt tacttcagtg tcagcgcgcg gcggccgtgg ctggctctgg       60

cgagagagca ccgagggagt gggtcgcaga tcttcgggcg gctaggggaa atcggcgaga      120

ggcgggatcc gagcgcgccg gcggggcgca gagcccgcga gcctggccag cgagggtagc      180

cgcggggggc gcgccccggg cgggcccccg gagacgcgca ggatgccaca cgaagagctg      240

ccgtcgctgc agagaccccg ctatggctct attgtggacg atgaaaggct ctctgcagag      300

gagatggatg agaggaggcg gcagaacatt gcttatgaat atctgtgcca cttagaggaa      360

gccaaaaggt ggatggaagt ttgcttagtt gaagaattgc caccaaccac tgaattggaa      420

gaagggctcc ggaatggagt ttaccttgca aagttagcca agttctttgc cccgaaaatg      480

gtatcagaga aaaagatcta tgatgtggaa caaacacgtt ataagaagtc tggccttcat      540

tttcgacaca cagataatac cgtccagtgg ttaagagcga tggagtctat tggtctaccc      600

aagatatttt atccagaaac aacagatgtc tatgatcgga aaaacatacc aagaatgata      660

tattgcattc acgcactgag tttgtatctg ttcaaactag gaatagcacc ccagatccag      720

gatttgttgg gcaaagtaga cttcacagag gaggaaatca gtaatatgag aaaagaactt      780

gagaaatatg gaatacagat gccatctttc agcaaaatag gtggtattct ggccaatgaa      840

ctgtccgtgg atgaagctgc attacatgct gcagttatag ccattaatga agcagttgaa      900

aaaggaatag cagagcaaac cgttgtaaca ctaagaaacc caaatgcggt tttaacttta      960

gtggatgaca accttgcacc agaatatcag aaagaactct gggatgccaa aaagaaaaaa     1020

gaggaaaatg caagactgaa gaatagctgt atttcagaag aagaaagaga tgcttatgaa     1080

gaactgctga cacaagcaga aatccaaggc aatattaata aagtcaacag gcaggctgca     1140

gtggaccata tcaatgctgt cattccggaa ggtgaccccg agaatacgct gcttgcactg     1200

aagaaaccag aggcccagct gcctgctgtt tatccctttg ctgctgccat gtatcagaac     1260

gaacttttca acctccagaa acagaacacc atgaactact tggcccacga ggagcttttg     1320

attgctgtgg aaatgttgtc tgctgttgct ttactaaacc aggccttgga aagcaacgat     1380

cttgtgtctg tgcagaatca actcagaagc cccgcaatag gcttaaacaa tctggacaag     1440

gcatatgtgg aacgttatgc aaacacacta ctctctgtta aactagaagt tttatcccaa     1500

gggcaagata acttaagctg gaatgaaatt cagaattgta ttgatatggt taatgctcaa     1560

attcaagaag aaaatgaccg agttgtagct gtagggtaca tcaatgaagc tattgatgaa     1620

gggaatcctt tgaggacttt agaaactttg ctcctaccta ctgcgaatat tagtgatgtg     1680

gacccagccc atgcccagca ctaccaggat gttttatacc atgctaaatc acagaaactc     1740

ggagactctg agagtgtttc caaagtgctt tggctggatg agatacagca agccgtcgat     1800

gatgccaacg tggacgagga cagagcaaaa caatgggtta ctctggtggt tgatgttaat     1860

cagtgtttgg aaggaaaaaa atcaagtgat attttgtctg tattgaagtc ttccacttct     1920

aatgcaaatg acataatccc ggagtgtgct gacaaatact atgatgccct tgtgaaggca     1980

aaagagctca aatctgaaag agtgtctagt gacggttcat ggctcaaact caacctgcac     2040

aaaaaatatg actactatta caacactgat tcaaaagaga gttcctgggt cacacctgaa     2100

tcatgcttgt ataaagaatc atggctcaca ggaaaagaaa tcgaggacat tattgaggaa     2160

gtcacagtag gttacattcg tgagaatata tggtctgctt cagaagagtt gcttcttcgc     2220

tttcaagcca caagctcagg acccatcctt agggaagagt ttgaagctag aaaatcattt     2280

ttgcatgaac aagaagagaa tgtggtcaaa atacaggctt tttggaaagg atataaacaa     2340

cggaaggagt atatgcacag gcggcaaacg ttcattgata atactgattc tattgtgaag     2400

attcagtcct ggttccgaat ggcaactgca agaaagagct atctttcaag actacagtat     2460

ttcagagatc ataataatga aattgtgaaa atacagtcac tgttgagagc gaacaaagct     2520

agagatgact acaaaacatt ggttggctct gaaaacccac cattaacagt aattcgcaaa     2580

tttgtatacc tgctggacca aagtgatttg gatttccagg aggaactaga ggttgcacga     2640

ttaagggaag aagtagtgac caagatcagg gccaatcaac agctggaaaa agacctgaac     2700

ctgatggaca tcaagattgg actgctggtg aagaacagga tcacactaga ggatgtaatt     2760

tcacacagta aaaagctgaa caagaaaaaa ggaggagaaa tggaaatact gaataacacc     2820

gacaaccaag gaataaaaag tttgagtaag gagaggagaa aaacactaga aacatatcag     2880

cagctgtttt accttttaca gaccaaccct ttatacttgg ctaagctgat tttccagatg     2940

ccacagaaca agtccactaa atttatggat actgttattt tcacactata taattatgcc     3000

tctaatcagc gagaagaata tctacttctc aagcttttta aaactgctct ggaggaagaa     3060

ataaaatcaa aagtggacca ggtacaggac atagttactg gtaaccctac agtcatcaag     3120

atggtcgtca gcttcaatag aggtgcccgg ggacagaaca ccctgcgcca actcctggct     3180

ccagtggtaa aagagatcat cgacgacaag tcgctgatta tcaacacaaa ccctgtagag     3240

gtgtacaagg cttgggtgaa ccaactagaa acacagactg gagaggccag caagttgcct     3300

tatgatgtga ccacagaaca agctctaaca tacccagaag tgaaaaataa actggaggct     3360

tccattgaga acctgagaag ggtcaccgac aaagtcctga attctatcat ttcttccctt     3420

gatctactgc cttatggatt gaggtatata gccaaagtac tgaagaattc gatccatgag     3480

aaattccccg atgcaacaga agatgagcta ttaaagattg ttggaaacct cctgtactat     3540

cggtacatga atccagccat tgtagctcca gatggctttg atatcatcga catgacagct     3600

ggaggtcaga taaattctga ccaaaggaga aacttaggat cagtggccaa ggttcttcag     3660

cacgcagcct ccaacaagct gtttgaagga gaaaatgagc atctctcatc tatgaacaat     3720

tatttatcag agacgtatca ggaattcagg aaatatttca aagaagcatg taatgtccct     3780

gagccagaag agaagtttaa tatggacaaa tacacagacc tggtgacagt cagcaaacca     3840

gtcatttata tttcaattga agaaatcatc agcacacact cactcctgtt ggaacaccag     3900

gatgcaattg cccctgagaa aaatgactta ctgagtgaat tgctggggtc gctgggagag     3960

gtgccaaccg tggaatcttt tcttggggaa ggagcagttg accccaatga ccctaacaag     4020

gcaaatacac taagtcagct ttcaaagacc gagatttctc ttgtcttgac aagcaaatat     4080

gacatagagg acggtgaagc tatagatagc cgaagcctca tgataaagac caagaagctg     4140

ataattgatg tgatccggaa ccagccaggg aacacattga cagaaatctt agagacacca     4200

gcaactgcgc aacaggaggt agaccatgcc acggacatgg tgagccgtgc aatgatagat     4260

tccaggactc cagaagaaat gaagcatagc caatctatga ttgaagatgc acagctgcct     4320

cttgagcaga agaagaggaa aatccagagg aatcttcgga cgttggaaca gactggacac     4380

gtgtcatccg aaaataaata ccaagacatt ctcaatgaga ttgccaagga tattcgaaat     4440

caaagaatct atcgtaagct tcgaaaagct gaattggcaa aacttcagca gaccctgaat     4500

gcacttaaca agaaggcagc attttatgaa gagcaaatca attattatga cacctacata     4560

aagacttgtt tagacaactt aaaaagaaaa aatactcgga gatcaattaa actagatgga     4620

aaaggagaac ccaaaggggc gaagagagcg aagccagtga agtacactgc agcaaagctg     4680

catgagaaag gtgtcctgct agatatagat gatcttcaaa caaaccagtt taagaatgtt     4740

acatttgata tcatagctac tgaagatgta ggcattttcg atgtaagatc aaaattcctt     4800

ggtgttgaga tggaaaaggt gcaactcaat attcaggatt tacttcagat gcaatatgaa     4860

ggagtagctg taatgaaaat gtttgataag gttaaagtga atgtaaacct tctcatatac     4920

ctgctgaaca agaagttcta tggaaagtga agtgcctaca gaaatttctt ggattctgta     4980

tcatctggat taggaaatga atttgtttaa tatttttgtt tttaaacatg attgaaatca     5040

ctgcttataa atgtgtgatt tttttaaaac gaccaaaact gttctgaaga atgtacccag     5100

gtgccttttt gctaatttga tactataata gaatgagaca taaaatgaat taatggaaac     5160

atatccacac tgtactgtga tataggtact ctgatttaaa actttggaca tcctgtgatc     5220

tgttttaaag ttggggggtg ggaaatttag ctgactaggg acaaacatgt aaacctattt     5280

tcctatgaaa aaaattttaa atgtcccact tgaataacgt aattcttcat agttttttta     5340

atctatggat aaatggaaac ctaattattt gtaatgaatt atttagacag ttctaagccc     5400

tgtcttctgg gagttatcaa ttttaaagag aacttttgtg caattcaaat gaagttttta     5460

taagtaattg aaaatgacaa cacaataaca ctttctgtat aaaagtatat attttatgtg     5520

atttattcct actaaatgaa agtgcactac tgcctcatgt aaagactctt gcacgcagag     5580

cctttaagtg actaaggaac aacatagata gtgagcatag tccccacctc cacccctcac     5640

aatttatttg aatacttcaa ttgtgcctct caattttttg taatgctaaa aaatcagtat     5700

ctagatggtt tttaaatgta ttctctggaa attgttttat gtaaaataaa tgttacttaa     5760

ttccattaa                                                             5769


<210>  60
<211>  1575
<212>  PRT
<213>  homo sapiens

<400>  60

Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser 
1               5                   10                  15      


Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg 
            20                  25                  30          


Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys 
        35                  40                  45              


Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu 
    50                  55                  60                  


Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys 
65                  70                  75                  80  


Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu 
                85                  90                  95      


Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn 
            100                 105                 110         


Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile 
        115                 120                 125             


Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg 
    130                 135                 140                 


Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly 
145                 150                 155                 160 


Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu 
                165                 170                 175     


Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln 
            180                 185                 190         


Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser 
        195                 200                 205             


Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala 
    210                 215                 220                 


Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro 
225                 230                 235                 240 


Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln 
                245                 250                 255     


Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu 
            260                 265                 270         


Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu 
        275                 280                 285             


Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln 
    290                 295                 300                 


Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu 
305                 310                 315                 320 


Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val 
                325                 330                 335     


Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln 
            340                 345                 350         


Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala 
        355                 360                 365             


Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser 
    370                 375                 380                 


Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly 
385                 390                 395                 400 


Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu 
                405                 410                 415     


Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser 
            420                 425                 430         


Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln 
        435                 440                 445             


Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile 
    450                 455                 460                 


Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr 
465                 470                 475                 480 


Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp 
                485                 490                 495     


Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val 
            500                 505                 510         


Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Asp Ala 
        515                 520                 525             


Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp 
    530                 535                 540                 


Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val 
545                 550                 555                 560 


Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala 
                565                 570                 575     


Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu 
            580                 585                 590         


Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys 
        595                 600                 605             


Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr 
    610                 615                 620                 


Pro Glu Ser Cys Leu Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile 
625                 630                 635                 640 


Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile 
                645                 650                 655     


Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser 
            660                 665                 670         


Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His 
        675                 680                 685             


Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr 
    690                 695                 700                 


Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn 
705                 710                 715                 720 


Thr Asp Ser Ile Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala 
                725                 730                 735     


Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn 
            740                 745                 750         


Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp 
        755                 760                 765             


Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile 
    770                 775                 780                 


Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu 
785                 790                 795                 800 


Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg 
                805                 810                 815     


Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile 
            820                 825                 830         


Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His 
        835                 840                 845             


Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn 
    850                 855                 860                 


Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys 
865                 870                 875                 880 


Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro 
                885                 890                 895     


Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr 
            900                 905                 910         


Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn 
        915                 920                 925             


Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu 
    930                 935                 940                 


Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly 
945                 950                 955                 960 


Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg 
                965                 970                 975     


Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile 
            980                 985                 990         


Ile Asp Asp Lys Ser Leu Ile Ile  Asn Thr Asn Pro Val  Glu Val Tyr 
        995                 1000                 1005             


Lys Ala  Trp Val Asn Gln Leu  Glu Thr Gln Thr Gly  Glu Ala Ser 
    1010                 1015                 1020             


Lys Leu  Pro Tyr Asp Val Thr  Thr Glu Gln Ala Leu  Thr Tyr Pro 
    1025                 1030                 1035             


Glu Val  Lys Asn Lys Leu Glu  Ala Ser Ile Glu Asn  Leu Arg Arg 
    1040                 1045                 1050             


Val Thr  Asp Lys Val Leu Asn  Ser Ile Ile Ser Ser  Leu Asp Leu 
    1055                 1060                 1065             


Leu Pro  Tyr Gly Leu Arg Tyr  Ile Ala Lys Val Leu  Lys Asn Ser 
    1070                 1075                 1080             


Ile His  Glu Lys Phe Pro Asp  Ala Thr Glu Asp Glu  Leu Leu Lys 
    1085                 1090                 1095             


Ile Val  Gly Asn Leu Leu Tyr  Tyr Arg Tyr Met Asn  Pro Ala Ile 
    1100                 1105                 1110             


Val Ala  Pro Asp Gly Phe Asp  Ile Ile Asp Met Thr  Ala Gly Gly 
    1115                 1120                 1125             


Gln Ile  Asn Ser Asp Gln Arg  Arg Asn Leu Gly Ser  Val Ala Lys 
    1130                 1135                 1140             


Val Leu  Gln His Ala Ala Ser  Asn Lys Leu Phe Glu  Gly Glu Asn 
    1145                 1150                 1155             


Glu His  Leu Ser Ser Met Asn  Asn Tyr Leu Ser Glu  Thr Tyr Gln 
    1160                 1165                 1170             


Glu Phe  Arg Lys Tyr Phe Lys  Glu Ala Cys Asn Val  Pro Glu Pro 
    1175                 1180                 1185             


Glu Glu  Lys Phe Asn Met Asp  Lys Tyr Thr Asp Leu  Val Thr Val 
    1190                 1195                 1200             


Ser Lys  Pro Val Ile Tyr Ile  Ser Ile Glu Glu Ile  Ile Ser Thr 
    1205                 1210                 1215             


His Ser  Leu Leu Leu Glu His  Gln Asp Ala Ile Ala  Pro Glu Lys 
    1220                 1225                 1230             


Asn Asp  Leu Leu Ser Glu Leu  Leu Gly Ser Leu Gly  Glu Val Pro 
    1235                 1240                 1245             


Thr Val  Glu Ser Phe Leu Gly  Glu Gly Ala Val Asp  Pro Asn Asp 
    1250                 1255                 1260             


Pro Asn  Lys Ala Asn Thr Leu  Ser Gln Leu Ser Lys  Thr Glu Ile 
    1265                 1270                 1275             


Ser Leu  Val Leu Thr Ser Lys  Tyr Asp Ile Glu Asp  Gly Glu Ala 
    1280                 1285                 1290             


Ile Asp  Ser Arg Ser Leu Met  Ile Lys Thr Lys Lys  Leu Ile Ile 
    1295                 1300                 1305             


Asp Val  Ile Arg Asn Gln Pro  Gly Asn Thr Leu Thr  Glu Ile Leu 
    1310                 1315                 1320             


Glu Thr  Pro Ala Thr Ala Gln  Gln Glu Val Asp His  Ala Thr Asp 
    1325                 1330                 1335             


Met Val  Ser Arg Ala Met Ile  Asp Ser Arg Thr Pro  Glu Glu Met 
    1340                 1345                 1350             


Lys His  Ser Gln Ser Met Ile  Glu Asp Ala Gln Leu  Pro Leu Glu 
    1355                 1360                 1365             


Gln Lys  Lys Arg Lys Ile Gln  Arg Asn Leu Arg Thr  Leu Glu Gln 
    1370                 1375                 1380             


Thr Gly  His Val Ser Ser Glu  Asn Lys Tyr Gln Asp  Ile Leu Asn 
    1385                 1390                 1395             


Glu Ile  Ala Lys Asp Ile Arg  Asn Gln Arg Ile Tyr  Arg Lys Leu 
    1400                 1405                 1410             


Arg Lys  Ala Glu Leu Ala Lys  Leu Gln Gln Thr Leu  Asn Ala Leu 
    1415                 1420                 1425             


Asn Lys  Lys Ala Ala Phe Tyr  Glu Glu Gln Ile Asn  Tyr Tyr Asp 
    1430                 1435                 1440             


Thr Tyr  Ile Lys Thr Cys Leu  Asp Asn Leu Lys Arg  Lys Asn Thr 
    1445                 1450                 1455             


Arg Arg  Ser Ile Lys Leu Asp  Gly Lys Gly Glu Pro  Lys Gly Ala 
    1460                 1465                 1470             


Lys Arg  Ala Lys Pro Val Lys  Tyr Thr Ala Ala Lys  Leu His Glu 
    1475                 1480                 1485             


Lys Gly  Val Leu Leu Asp Ile  Asp Asp Leu Gln Thr  Asn Gln Phe 
    1490                 1495                 1500             


Lys Asn  Val Thr Phe Asp Ile  Ile Ala Thr Glu Asp  Val Gly Ile 
    1505                 1510                 1515             


Phe Asp  Val Arg Ser Lys Phe  Leu Gly Val Glu Met  Glu Lys Val 
    1520                 1525                 1530             


Gln Leu  Asn Ile Gln Asp Leu  Leu Gln Met Gln Tyr  Glu Gly Val 
    1535                 1540                 1545             


Ala Val  Met Lys Met Phe Asp  Lys Val Lys Val Asn  Val Asn Leu 
    1550                 1555                 1560             


Leu Ile  Tyr Leu Leu Asn Lys  Lys Phe Tyr Gly Lys  
    1565                 1570                 1575 


<210>  61
<211>  4803
<212>  DNA
<213>  homo sapiens

<400>  61
gactcgggag ttgccggcgc ttcccggcgg tggcggcgtc tctggccggc cttggtgcgg       60

cgagccgagc gaggcagctc tgagccgcgc ggaaatctgg cattttttaa agtttgcgcc      120

ccacaaagag gaaatattcc aaaggtactc aggatgtaaa aggggagatc ttcacagatg      180

cctccgtgga tggcatggca atccatccat caatgagaag accatgattt cttttaattt      240

tctgtgtgtt tccacattcc ccagtgagaa ttcttccacc tttttttgtg ccatgggaaa      300

aacctgaagg gcaggcagag ctgctcccga acttgtgacc ttctctgagg ttgcagcggc      360

tcttgtagaa catgactctg ggacatcact tccttttgtt ttctttcgga gctgaaccaa      420

agaatgtgca ccctctttct ctagtgctgt ggtgtctgct tatttttgta tttgtgcttt      480

ccatccatct tctgtgatca caaggcattc ttaaggtttt ctagcacgac ttgcggacat      540

ccagactcgt ggggggccca cccatggctc ggtaagccag cagcccaggg cactggcact      600

accatgaggc actgcattaa ttgctgcata cagctgttac ccgacggcgc acacaagcag      660

caggtcaact gccaaggggg cccccatcac ggtcaccagg cgtgccccac gtgcaaagga      720

gaaaacaaaa ttctgtttcg tgtggacagt aagcagatga acttgcttgc tgttctcgaa      780

gtgaggactg aagggaacga aaactggggt gggtttttgc gcttcaaaaa ggggaagcga      840

tgtagcctcg tttttggact gataataatg accttggtaa tggcttctta catcctttct      900

ggggcccacc aagagcttct gatctcatca cctttccatt acggaggctt ccccagcaac      960

cccagcttga tggacagcga aaacccaagt gacacaaagg agcatcacca ccaatcctct     1020

gtaaataata tttcatacat gaaggactat ccaagcatta aattaattat caacagcatc     1080

acaactagga ttgagttcac gaccagacag ctcccagact tagaagacct taagaagcag     1140

gagttgcata tgttttcagt catccccaac aaattccttc caaacagtaa gagcccctgt     1200

tggtacgagg agttctcggg gcagaacacc accgacccct acctcaccaa ctcctacgtg     1260

ctctactcca agcgcttccg ctccaccttc gacgccctgc gcaaggcctt ctggggccac     1320

ctggcgcacg cgcacgggaa gcacttccgc ctgcgctgcc tgccgcactt ctacatcata     1380

gggcagccca agtgcgggac cacagacctc tatgaccgcc tgcggctgca ccctgaggtc     1440

aagttctccg ccatcaagga gccacactgg tggacccgga agcgctttgg aatcgtccgc     1500

ctaagagatg ggctgcgaga ccgctatccc gtggaagatt atctggacct ctttgacctg     1560

gccgcacacc agatccatca aggactgcag gccagctctg caaaggagca gagcaagatg     1620

aatacaatca ttatcgggga ggccagtgcc tccacgatgt gggataataa tgcctggacg     1680

ttcttctacg acaacagcac ggatggcgag ccaccgtttc tgacgcagga cttcatccac     1740

gcctttcagc caaatgccag actgattgtc atgctcaggg accctgtgga gaggttgtac     1800

tcagactatc tctactttgc aagttcgaat aaatccgcgg acgacttcca tgagaaagtg     1860

acagaagcac tgcagctgtt tgaaaattgc atgcttgatt attcactgcg cgcctgcgtc     1920

tacaacaaca ccctcaacaa cgccatgcct gtgaggctcc aggttgggct ctatgctgtg     1980

taccttctgg actggctcag cgtttttgac aagcaacagt ttctcattct tcgcctggaa     2040

gatcatgcat ccaacgtcaa gtacaccatg cacaaggtct tccagtttct gaacctaggg     2100

cccttaagtg agaagcagga ggctttgatg accaagagcc ccgcatccaa tgcacggcgt     2160

cccgaggacc ggaacctggg gcccatgtgg cccatcacac agaagattct gcgggatttc     2220

tacaggccct tcaacgctag gctggcgcag gtcctcgcgg atgaggcgtt tgcgtggaag     2280

acgacgtgag agctgaattg ttgctgcacg tgctgggccc gccaatgccg tcatcatcag     2340

gattttacaa atctctttgc ggggaactgt ttcactcatg gtatggaaaa ccccaggact     2400

ctgccactct aggcacacat gaattataac cattttggaa tttccttcgt gatgttcgag     2460

agctcagcaa tggacccctc acagagctcc tctatccgag gccattggag accccagttt     2520

ctcaagaatt cagctctgct ctgagcgtcc tggagcttgg ggatgcagcc agctggcctg     2580

cactgggtgt ggagagaaca cctagggaag gcagcctggc cctgcccgcc tccgccttct     2640

ggagagcctc tgggttctga gtcagcaagc cagaggtcat gccacaggcc tggctggaac     2700

ttacacttca cgttcccttt ttttccccct agagatgggg tctcgccgtg ttgcacagac     2760

tgtctgtatt caatggctat cttcacaggt gtgatcatac cacattcact tctgaaacac     2820

tcttgttgcg atcgctaacc tcactgggac agagaaccgc agtctttcga gaatggaggc     2880

tcttcatttt ttttttctcc tttactccaa actcagccct ccagtttctt cagatgtaaa     2940

ccctgttaac gtcactgttt ccaaaaggaa aaaaataagt cagtttttgg cagcaccttc     3000

atctttctga cctcctccta ttctgtcctt gtggacttat gtttaacata gaaaatgaat     3060

gcgtttaaaa caaaaccact ttctgcattt aaccagtcct ggctctctct ctgctgcctc     3120

ttcatacgtt ttctcaagaa cttcagttta taattggaag agaaattttt gctgttaatg     3180

ccagaatgag caacctcaag gaattgaaca cttcttggaa aatctaggta attcaagccc     3240

tcatcaggtt tacaagatca tcagagaaac agaggatttt aatttttagt tctggccggc     3300

tacaggctcc atttctctgc cttcccattg gaaatagttt atttccacat tctccactgc     3360

gtgtggtcaa agttcctcac ccagcaaggg actatagata ctcgtgtccc aattccaaaa     3420

cacaatgcac aagctgaact tgggctgaac gtggcgtgtt gagatttgga atgaggtttc     3480

taagagccgt gttcttcatg gaattttcca ggccacttgg cagcttggtt taccgatgga     3540

tgggctagag atcttgtcgt ttcttggaag tcacagggaa gattgaagag aacgcttgag     3600

catccttggc aacagcccag gtgggacctg gatgaagctt tgcactcaag tattgtcaag     3660

ggaagcttcc tgtgaaccaa agttctcagg ccaaggtctc gcccaccaaa gccagaaagt     3720

gcaagcaccc gtctacccag ctctaacttg tatgtgtgag acagaccagg cttcgggggt     3780

aggaggatct gcagttgttc agccgtcttt ctgctggtgt tgtctttctg ccatcagaga     3840

agggacacac agcccgttcg aaggtgtgca gagggctctg agcgccagga tggccagggc     3900

tgtttttgct actgaaggag cgtgtgtcct gaactcccac ttgcagggac agtccccacc     3960

ttctctatag ccggcactgg gagcagccgc cagcagggaa atctggcctg agcacaagga     4020

tgctttaggg agagatcact tcagtgtgtg tgtatattta tttgcagtac agtgcgcgcg     4080

tgtgtgtgtg tgtacgcgca cgtgtgggtg agtgcgtctt ctgagtgggt tctgttcagt     4140

tgctaatgag gctcctccgc tctggacaca acccttttat agattaattt ctctgccaat     4200

taacttgtca ttttcagtac atattttact attccacacc aaccataatt acaacaaggg     4260

atttttctta tgcactccta tgcatgtgaa taacatgtgg tgtaattctg cttcttacag     4320

aagtattact gaaggtatta tttccaatat tatttggttt attatgcgga tcttttttat     4380

atatgcagtc ccatcccttc tgtgccactc aatgccatcc agacatggtt tttccctcca     4440

ggggcctttc tctccagagg gcacttcggc tgcctctgct tcctctcatt cgaggcccgg     4500

ctcttgctga cagaataggt tccgttctgg gcggtggttc tcgagcctgc cattcaaaac     4560

caaagcaaat tggagcattt ctcacaacat ggtattgaag ttcctttttg ttctcaaaag     4620

ttgtgaccgt gttaaattgt actcccttag tcctgtaagg tatgttaagt gaatcgcagt     4680

tacgctgtac ttttattaat atttaacata attaaagatg gacccataag agtgacgcct     4740

gtggagcgcg tgctcttcct ctgcagccaa gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4800

aaa                                                                   4803


<210>  62
<211>  561
<212>  PRT
<213>  homo sapiens

<400>  62

Met Arg His Cys Ile Asn Cys Cys Ile Gln Leu Leu Pro Asp Gly Ala 
1               5                   10                  15      


His Lys Gln Gln Val Asn Cys Gln Gly Gly Pro His His Gly His Gln 
            20                  25                  30          


Ala Cys Pro Thr Cys Lys Gly Glu Asn Lys Ile Leu Phe Arg Val Asp 
        35                  40                  45              


Ser Lys Gln Met Asn Leu Leu Ala Val Leu Glu Val Arg Thr Glu Gly 
    50                  55                  60                  


Asn Glu Asn Trp Gly Gly Phe Leu Arg Phe Lys Lys Gly Lys Arg Cys 
65                  70                  75                  80  


Ser Leu Val Phe Gly Leu Ile Ile Met Thr Leu Val Met Ala Ser Tyr 
                85                  90                  95      


Ile Leu Ser Gly Ala His Gln Glu Leu Leu Ile Ser Ser Pro Phe His 
            100                 105                 110         


Tyr Gly Gly Phe Pro Ser Asn Pro Ser Leu Met Asp Ser Glu Asn Pro 
        115                 120                 125             


Ser Asp Thr Lys Glu His His His Gln Ser Ser Val Asn Asn Ile Ser 
    130                 135                 140                 


Tyr Met Lys Asp Tyr Pro Ser Ile Lys Leu Ile Ile Asn Ser Ile Thr 
145                 150                 155                 160 


Thr Arg Ile Glu Phe Thr Thr Arg Gln Leu Pro Asp Leu Glu Asp Leu 
                165                 170                 175     


Lys Lys Gln Glu Leu His Met Phe Ser Val Ile Pro Asn Lys Phe Leu 
            180                 185                 190         


Pro Asn Ser Lys Ser Pro Cys Trp Tyr Glu Glu Phe Ser Gly Gln Asn 
        195                 200                 205             


Thr Thr Asp Pro Tyr Leu Thr Asn Ser Tyr Val Leu Tyr Ser Lys Arg 
    210                 215                 220                 


Phe Arg Ser Thr Phe Asp Ala Leu Arg Lys Ala Phe Trp Gly His Leu 
225                 230                 235                 240 


Ala His Ala His Gly Lys His Phe Arg Leu Arg Cys Leu Pro His Phe 
                245                 250                 255     


Tyr Ile Ile Gly Gln Pro Lys Cys Gly Thr Thr Asp Leu Tyr Asp Arg 
            260                 265                 270         


Leu Arg Leu His Pro Glu Val Lys Phe Ser Ala Ile Lys Glu Pro His 
        275                 280                 285             


Trp Trp Thr Arg Lys Arg Phe Gly Ile Val Arg Leu Arg Asp Gly Leu 
    290                 295                 300                 


Arg Asp Arg Tyr Pro Val Glu Asp Tyr Leu Asp Leu Phe Asp Leu Ala 
305                 310                 315                 320 


Ala His Gln Ile His Gln Gly Leu Gln Ala Ser Ser Ala Lys Glu Gln 
                325                 330                 335     


Ser Lys Met Asn Thr Ile Ile Ile Gly Glu Ala Ser Ala Ser Thr Met 
            340                 345                 350         


Trp Asp Asn Asn Ala Trp Thr Phe Phe Tyr Asp Asn Ser Thr Asp Gly 
        355                 360                 365             


Glu Pro Pro Phe Leu Thr Gln Asp Phe Ile His Ala Phe Gln Pro Asn 
    370                 375                 380                 


Ala Arg Leu Ile Val Met Leu Arg Asp Pro Val Glu Arg Leu Tyr Ser 
385                 390                 395                 400 


Asp Tyr Leu Tyr Phe Ala Ser Ser Asn Lys Ser Ala Asp Asp Phe His 
                405                 410                 415     


Glu Lys Val Thr Glu Ala Leu Gln Leu Phe Glu Asn Cys Met Leu Asp 
            420                 425                 430         


Tyr Ser Leu Arg Ala Cys Val Tyr Asn Asn Thr Leu Asn Asn Ala Met 
        435                 440                 445             


Pro Val Arg Leu Gln Val Gly Leu Tyr Ala Val Tyr Leu Leu Asp Trp 
    450                 455                 460                 


Leu Ser Val Phe Asp Lys Gln Gln Phe Leu Ile Leu Arg Leu Glu Asp 
465                 470                 475                 480 


His Ala Ser Asn Val Lys Tyr Thr Met His Lys Val Phe Gln Phe Leu 
                485                 490                 495     


Asn Leu Gly Pro Leu Ser Glu Lys Gln Glu Ala Leu Met Thr Lys Ser 
            500                 505                 510         


Pro Ala Ser Asn Ala Arg Arg Pro Glu Asp Arg Asn Leu Gly Pro Met 
        515                 520                 525             


Trp Pro Ile Thr Gln Lys Ile Leu Arg Asp Phe Tyr Arg Pro Phe Asn 
    530                 535                 540                 


Ala Arg Leu Ala Gln Val Leu Ala Asp Glu Ala Phe Ala Trp Lys Thr 
545                 550                 555                 560 


Thr 
    


<210>  63
<211>  1879
<212>  DNA
<213>  homo sapiens

<400>  63
agttccaagt ttggagcttt tagctgccag ccctggccca tcatgtagct gcagcacagc       60

cttccctaac gttgcaactg ggggaaaaat cactttccag tctgttttgc aaggtgtgca      120

tttccatctt gattccctga aagtccatct gctgcatcgg tcaagagaaa ctccacttgc      180

atgaagattg cacgcctgca gcttgcatct ttgttgcaaa actagctaca gaagagaagc      240

aaggcaaagt cttttgtgct cccctccccc atcaaaggaa aggggaaaat gtctcagtcg      300

aaaggcaaga agcgaaaccc tggccttaaa attccaaaag aagcatttga acaacctcag      360

accagttcca caccacctcg agatttagac tccaaggctt gcatttctat tggaaatcag      420

aactttgagg tgaaggcaga tgacctggag cctataatgg aactgggacg aggtgcgtac      480

ggggtggtgg agaagatgcg gcacgtgccc agcgggcaga tcatggcagt gaagcggatc      540

cgagccacag taaatagcca ggaacagaaa cggctactga tggatttgga tatttccatg      600

aggacggtgg actgtccatt cactgtcacc ttttatggcg cactgtttcg ggagggtgat      660

gtgtggatct gcatggagct catggataca tcactagata aattctacaa acaagttatt      720

gataaaggcc agacaattcc agaggacatc ttagggaaaa tagcagtttc tattgtaaaa      780

gcattagaac atttacatag taagctgtct gtcattcaca gagacgtcaa gccttctaat      840

gtactcatca atgctctcgg tcaagtgaag atgtgcgatt ttggaatcag tggctacttg      900

gtggactctg ttgctaaaac aattgatgca ggttgcaaac catacatggc ccctgaaaga      960

ataaacccag agctcaacca gaagggatac agtgtgaagt ctgacatttg gagtctgggc     1020

atcacgatga ttgagttggc catccttcga tttccctatg attcatgggg aactccattt     1080

cagcagctca aacaggtggt agaggagcca tcgccacaac tcccagcaga caagttctct     1140

gcagagtttg ttgactttac ctcacagtgc ttaaagaaga attccaaaga acggcctaca     1200

tacccagagc taatgcaaca tccatttttc accctacatg aatccaaagg aacagatgtg     1260

gcatcttttg taaaactgat tcttggagac taaaaagcag tggacttaat cggttgaccc     1320

tactgtggat tggtgggttt cggggtgaag caagttcact acagcatcaa tagaaagtca     1380

tctttgagat aatttaaccc tgcctctcag agggttttct ctcccaattt tctttttact     1440

ccccctctta agggggcctt ggaatctata gtatagaatg aactgtctag atggatgaat     1500

tatgataaag gcttaggact tcaaaaggtg attaaatatt taatgatgtg tcatatgagt     1560

cctcaagctt ctcagacttc tcttattctt tacaaaatga atgcattggc cctgacaaaa     1620

aggtgctacg gtagtgatga aattataagt agatttgtag tttgtcccat ttattatttt     1680

aatatttatg tttaagtgct tggttgaaaa gattccattt tatacaagaa gggagattca     1740

aaaaaaaaat ataaggttgg gttagcaata tttatagggc ttttattttt taagttcaat     1800

tgtgtctgtg gtccagaaga aattatttaa tatgcatctt tgagaatatt ataaaaatat     1860

caaaaaggaa aaaaaaaaa                                                  1879


<210>  64
<211>  334
<212>  PRT
<213>  homo sapiens

<400>  64

Met Ser Gln Ser Lys Gly Lys Lys Arg Asn Pro Gly Leu Lys Ile Pro 
1               5                   10                  15      


Lys Glu Ala Phe Glu Gln Pro Gln Thr Ser Ser Thr Pro Pro Arg Asp 
            20                  25                  30          


Leu Asp Ser Lys Ala Cys Ile Ser Ile Gly Asn Gln Asn Phe Glu Val 
        35                  40                  45              


Lys Ala Asp Asp Leu Glu Pro Ile Met Glu Leu Gly Arg Gly Ala Tyr 
    50                  55                  60                  


Gly Val Val Glu Lys Met Arg His Val Pro Ser Gly Gln Ile Met Ala 
65                  70                  75                  80  


Val Lys Arg Ile Arg Ala Thr Val Asn Ser Gln Glu Gln Lys Arg Leu 
                85                  90                  95      


Leu Met Asp Leu Asp Ile Ser Met Arg Thr Val Asp Cys Pro Phe Thr 
            100                 105                 110         


Val Thr Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Val Trp Ile Cys 
        115                 120                 125             


Met Glu Leu Met Asp Thr Ser Leu Asp Lys Phe Tyr Lys Gln Val Ile 
    130                 135                 140                 


Asp Lys Gly Gln Thr Ile Pro Glu Asp Ile Leu Gly Lys Ile Ala Val 
145                 150                 155                 160 


Ser Ile Val Lys Ala Leu Glu His Leu His Ser Lys Leu Ser Val Ile 
                165                 170                 175     


His Arg Asp Val Lys Pro Ser Asn Val Leu Ile Asn Ala Leu Gly Gln 
            180                 185                 190         


Val Lys Met Cys Asp Phe Gly Ile Ser Gly Tyr Leu Val Asp Ser Val 
        195                 200                 205             


Ala Lys Thr Ile Asp Ala Gly Cys Lys Pro Tyr Met Ala Pro Glu Arg 
    210                 215                 220                 


Ile Asn Pro Glu Leu Asn Gln Lys Gly Tyr Ser Val Lys Ser Asp Ile 
225                 230                 235                 240 


Trp Ser Leu Gly Ile Thr Met Ile Glu Leu Ala Ile Leu Arg Phe Pro 
                245                 250                 255     


Tyr Asp Ser Trp Gly Thr Pro Phe Gln Gln Leu Lys Gln Val Val Glu 
            260                 265                 270         


Glu Pro Ser Pro Gln Leu Pro Ala Asp Lys Phe Ser Ala Glu Phe Val 
        275                 280                 285             


Asp Phe Thr Ser Gln Cys Leu Lys Lys Asn Ser Lys Glu Arg Pro Thr 
    290                 295                 300                 


Tyr Pro Glu Leu Met Gln His Pro Phe Phe Thr Leu His Glu Ser Lys 
305                 310                 315                 320 


Gly Thr Asp Val Ala Ser Phe Val Lys Leu Ile Leu Gly Asp 
                325                 330                 


<210>  65
<211>  2707
<212>  DNA
<213>  homo sapiens

<400>  65
catctttgag caagatgggt ctctaccgca tccgcgtgtc cactggggcc tcgctctatg       60

ccggttccaa caaccaggtg cagctgtggc tggtcggcca gcacggggag gcggcgctcg      120

ggaagcgact gtggcccgca cggggcaagg agacagaact caaggtggaa gtaccggagt      180

atctggggcc gctgctgttt gtgaaactgc gcaaacggca cctccttaag gacgacgcct      240

ggttctgcaa ctggatctct gtgcagggcc ccggagccgg ggacgaggtc aggttccctt      300

gttaccgctg ggtggagggc aacggcgtcc tgagcctgcc tgaaggcacc ggccgcactg      360

tgggcgagga ccctcagggc ctgttccaga aacaccggga agaagagctg gaagagagaa      420

ggaagttgta ccggtgggga aactggaagg acgggttaat tctgaatatg gctggggcca      480

aactatatga cctccctgtg gatgagcgat ttctggaaga caagagagtt gactttgagg      540

tttcgctggc caaggggctg gccgacctcg ctatcaaaga ctctctaaat gttctgactt      600

gctggaagga tctagatgac ttcaaccgga ttttctggtg tggtcagagc aagctggctg      660

agcgcgtgcg ggactcctgg aaggaagatg ccttatttgg gtaccagttt cttaatggcg      720

ccaaccccgt ggtgctgagg cgctctgctc accttcctgc tcgcctagtg ttccctccag      780

gcatggagga actgcaggcc cagctggaga aggagctgga gggaggcaca ctgttcgaag      840

ctgacttctc cctgctggat gggatcaagg ccaacgtcat tctctgtagc cagcagcacc      900

tggctgcccc tctagtcatg ctgaaattgc agcctgatgg gaaactcttg cccatggtca      960

tccagctcca gctgccccgc acaggatccc caccacctcc ccttttcttg cctacggatc     1020

ccccaatggc ctggcttctg gccaaatgct gggtgcgcag ctctgacttc cagctccatg     1080

agctgcagtc tcatcttctg aggggacact tgatggctga ggtcattgtt gtggccacca     1140

tgaggtgcct gccgtcgata catcctatct tcaagcttat aattccccac ctgcgataca     1200

ccctggaaat taacgtccgg gccaggactg ggctggtctc tgacatggga attttcgacc     1260

agataatgag cactggtggg ggaggccacg tgcagctgct caagcaagct ggagccttcc     1320

taacctacag ctccttctgt ccccctgatg acttggccga ccgggggctc ctgggagtga     1380

agtcttcctt ctatgcccaa gatgcgctgc ggctctggga aatcatctat cggtatgtgg     1440

aaggaatcgt gagtctccac tataagacag acgtggctgt gaaagacgac ccagagctgc     1500

agacctggtg tcgagagatc actgaaatcg ggctgcaagg ggcccaggac cgagggtttc     1560

ctgtctcttt acaggctcgg gaccaggttt gccactttgt caccatgtgt atcttcacct     1620

gcaccggcca acacgcctct gtgcacctgg gccagctgga ctggtactct tgggtgccta     1680

atgcaccctg cacgatgcgg ctgcccccgc caaccaccaa ggatgcaacg ctggagacag     1740

tgatggcgac actgcccaac ttccaccagg cttctctcca gatgtccatc acttggcagc     1800

tgggcagacg ccagcccgtt atggtggctg tgggccagca tgaggaggag tatttttcgg     1860

gccctgagcc taaggctgtg ctgaagaagt tcagggagga gctggctgcc ctggataagg     1920

aaattgagat ccggaatgca aagctggaca tgccctacga gtacctgcgg cccagcgtgg     1980

tggaaaacag tgtggccatc taagcgtcgc caccctttgg ttatttcagc ccccatcacc     2040

caagccacaa gctgacccct tcgtggttat agccctgccc tcccaagtcc caccctcttc     2100

ccatgtccca ccctccctag aggggcacct tttcatggtc tctgcaccca gtgaacacat     2160

tttactctag aggcatcacc tgggacctta ctcctctttc cttccttcct cctttcctat     2220

cttccttcct ctctctcttc ctctttcttc attcagatct atatggcaaa tagccacaat     2280

tatataaatc atttcaagac tagaataggg ggatataata catattactc cacacctttt     2340

atgaatcaaa tatgattttt ttgttgttgt taagacagag tctcactttg acacccaggc     2400

tggagtgcag tggtgccatc accacggctc actgcagcct cagcgtcctg ggctcaaatg     2460

atcctcccac ctcagcctcc tgagtagctg ggactacagg ctcatgccat catgcccagc     2520

taatattttt ttattttcgt ggagacgggg cctcactatg ttgcctaggc tggaaatagg     2580

attttgaacc caaattgagt ttaacaataa taaaaagttg ttttacgcta aagatggaaa     2640

agaactagga ctgaactatt ttaaataaaa tattggcaaa agaaaaaaaa aaaaaaaaaa     2700

aaaaaaa                                                               2707


<210>  66
<211>  662
<212>  PRT
<213>  homo sapiens

<400>  66

Met Gly Leu Tyr Arg Ile Arg Val Ser Thr Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Thr Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro Glu Gly Thr 
            100                 105                 110         


Gly Arg Thr Val Gly Glu Asp Pro Gln Gly Leu Phe Gln Lys His Arg 
        115                 120                 125             


Glu Glu Glu Leu Glu Glu Arg Arg Lys Leu Tyr Arg Trp Gly Asn Trp 
    130                 135                 140                 


Lys Asp Gly Leu Ile Leu Asn Met Ala Gly Ala Lys Leu Tyr Asp Leu 
145                 150                 155                 160 


Pro Val Asp Glu Arg Phe Leu Glu Asp Lys Arg Val Asp Phe Glu Val 
                165                 170                 175     


Ser Leu Ala Lys Gly Leu Ala Asp Leu Ala Ile Lys Asp Ser Leu Asn 
            180                 185                 190         


Val Leu Thr Cys Trp Lys Asp Leu Asp Asp Phe Asn Arg Ile Phe Trp 
        195                 200                 205             


Cys Gly Gln Ser Lys Leu Ala Glu Arg Val Arg Asp Ser Trp Lys Glu 
    210                 215                 220                 


Asp Ala Leu Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Val Val 
225                 230                 235                 240 


Leu Arg Arg Ser Ala His Leu Pro Ala Arg Leu Val Phe Pro Pro Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Glu Gly Gly Thr 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ser Leu Leu Asp Gly Ile Lys Ala Asn Val 
        275                 280                 285             


Ile Leu Cys Ser Gln Gln His Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Leu Gln Pro Asp Gly Lys Leu Leu Pro Met Val Ile Gln Leu Gln Leu 
305                 310                 315                 320 


Pro Arg Thr Gly Ser Pro Pro Pro Pro Leu Phe Leu Pro Thr Asp Pro 
                325                 330                 335     


Pro Met Ala Trp Leu Leu Ala Lys Cys Trp Val Arg Ser Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Leu Gln Ser His Leu Leu Arg Gly His Leu Met Ala 
        355                 360                 365             


Glu Val Ile Val Val Ala Thr Met Arg Cys Leu Pro Ser Ile His Pro 
    370                 375                 380                 


Ile Phe Lys Leu Ile Ile Pro His Leu Arg Tyr Thr Leu Glu Ile Asn 
385                 390                 395                 400 


Val Arg Ala Arg Thr Gly Leu Val Ser Asp Met Gly Ile Phe Asp Gln 
                405                 410                 415     


Ile Met Ser Thr Gly Gly Gly Gly His Val Gln Leu Leu Lys Gln Ala 
            420                 425                 430         


Gly Ala Phe Leu Thr Tyr Ser Ser Phe Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Val Lys Ser Ser Phe Tyr Ala Gln Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Tyr Arg Tyr Val Glu Gly Ile Val Ser 
465                 470                 475                 480 


Leu His Tyr Lys Thr Asp Val Ala Val Lys Asp Asp Pro Glu Leu Gln 
                485                 490                 495     


Thr Trp Cys Arg Glu Ile Thr Glu Ile Gly Leu Gln Gly Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Leu Gln Ala Arg Asp Gln Val Cys His Phe 
        515                 520                 525             


Val Thr Met Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Val His 
    530                 535                 540                 


Leu Gly Gln Leu Asp Trp Tyr Ser Trp Val Pro Asn Ala Pro Cys Thr 
545                 550                 555                 560 


Met Arg Leu Pro Pro Pro Thr Thr Lys Asp Ala Thr Leu Glu Thr Val 
                565                 570                 575     


Met Ala Thr Leu Pro Asn Phe His Gln Ala Ser Leu Gln Met Ser Ile 
            580                 585                 590         


Thr Trp Gln Leu Gly Arg Arg Gln Pro Val Met Val Ala Val Gly Gln 
        595                 600                 605             


His Glu Glu Glu Tyr Phe Ser Gly Pro Glu Pro Lys Ala Val Leu Lys 
    610                 615                 620                 


Lys Phe Arg Glu Glu Leu Ala Ala Leu Asp Lys Glu Ile Glu Ile Arg 
625                 630                 635                 640 


Asn Ala Lys Leu Asp Met Pro Tyr Glu Tyr Leu Arg Pro Ser Val Val 
                645                 650                 655     


Glu Asn Ser Val Ala Ile 
            660         


<210>  67
<211>  11023
<212>  DNA
<213>  homo sapiens

<400>  67
gttattaact gtaagactgt ttgaattgtc aggtctttgt ggtgagctga attctgcatg       60

gcagtgctta ctgtgcagaa aggttgcaat gcctcacttt gccttaatcc atgttcctct      120

aacttcctta ctctttctct caagaggagg caagtggctg tggcggccgc agcagtggct      180

gatcatcact gaaaatacca aagaaaagaa ctgagctgcc tccttcatat tttttccatt      240

gaggattaat ttaccgtgct ttttcatttt ctctacatcc tgcaaaagtt tttttctctc      300

ctaagaaaca aactatgaac tgattgttga aaaaaagaag taaaaagttt tagcacagct      360

tctctgtctc ttcgggacaa gttagaaaat tctgaagtga gccgaagcat agtaagtgct      420

ttctttcttt ttaagctact tctggggagg gaggaggcta ttgtaatggt aaatttcact      480

ccgagaggaa gaaagggttg ataatcaatc aaaaatgagg tattcctttg agtatttgtg      540

attttcttac tatattgtaa gatgctttta attttctctg taaaataggc agaaatggtt      600

ttagtgtgtg tatgtgtgaa ataaaagctc agaaaagcaa tcttcagagc gccactgaag      660

gaagttttga cgaacggagt agagatgtat accacttggg ggcttcagtg agaacccaga      720

attcctggag gaggatttac attcagaaat gttgaagtga aaattccttc tggttcagca      780

tcttggagtt cagcttggaa gaacatttta cgtatggaag aatttgcttc tccaaacctc      840

tcttttggcc attgtgtgtc ctgaaggatg ggacaacttg tgctgtagaa gcactgcttg      900

cctgagtttg cttcaggcat tttaaattta acttgaggga tcatgtgttt ggcatgatga      960

ggaccactga agacttccac aagcctagtg ccacattaaa ctctaacacg gccaccaagg     1020

gaaggtacat ttatctggag gcattcctgg agggaggagc tccctggggt tttactctaa     1080

agggtggcct ggagcacgga gaaccattaa tcatctctaa ggtcgaagaa gggggcaaag     1140

cagacaccct gagctccaaa ctgcaggctg gggatgaggt tgtgcacatc aatgaggtga     1200

ctctgagcag ctccagaaag gaggcagttt ccctggtgaa aggatcctac aagaccctca     1260

ggctggtagt gcgcagagat gtgtgcacag acccaggcca tgcagatact ggtgcctcta     1320

acttcgtcag cccagaacac ctcacctctg gcccccagca caggaaagca gcgtggtcag     1380

gaggggttaa acttcggctg aagcacaggc gcagtgagcc tgcaggccga cctcactcgt     1440

ggcacacaac taaatctggg gagaagcaac ccgatgccag catgatgcag atatctcagg     1500

gtatgatcgg ccctccttgg caccaaagct accattccag ctcctctact agtgacctct     1560

ccaactatga ccatgcttat ctaaggcgga gccctgacca gtgcagctcc caggggagca     1620

tggagagcct ggagcccagt ggggcatacc caccctgtca tctttcccct gccaagtcca     1680

ccggcagcat tgaccagctc agccacttcc ataacaagag agactcggct tacagctctt     1740

tctccaccag ttctagcatc ctagagtatc cacaccctgg catctctggc cgggagcgtt     1800

caggctccat ggacaatact tctgctcgag gtggcctcct cgaagggatg aggcaggcag     1860

atattcgcta tgtcaagaca gtctatgaca cccggagggg agtctcagca gagtatgagg     1920

tgaactcttc agccctgctg cttcaaggta gggaggcccg agcctcagca aatggtcagg     1980

gctatgataa atggtctaat attcctcggg gcaagggagt gccaccccca tcctggagcc     2040

agcagtgccc cagttccttg gagactgcca cggacaacct tcctcctaag gtgggtgcac     2100

ccctgcctcc agctcggagt gacagttacg cagcatttcg gcaccgtgag cggcccagct     2160

cctggtctag ccttgatcag aaacggctct gccggcctca ggcaaactct ttaggctccc     2220

tgaagtctcc attcatagag gagcagctgc atactgtgct ggagaagagt ccagagaaca     2280

gccccccagt gaagcccaag cataactata cccagaaggc ccaacctggc caacctctgc     2340

tgccgaccag catctacccg gtaccttccc tggagccaca ctttgcccag gtgcctcagc     2400

cttctgtgag tagcaacggt atgctctacc ctgcactggc caaggagagt ggatacatag     2460

cccctcaggg agcatgcaac aagatggcta ccattgatga gaatgggaac cagaatggat     2520

ctggcaggcc tgggtttgcc ttctgccagc ccttagaaca tgacttgctg tccccagtgg     2580

agaagaaacc agaagctaca gccaagtatg tcccctccaa agtccatttc tgttcagtgc     2640

ctgaaaatga ggaggatgcc tccctgaaga gacatctcac acctccccaa ggcaacagcc     2700

cacattccaa tgagagaaag agcacccaca gtaacaaacc atcttctcat ccccacagcc     2760

tcaaatgccc tcaggctcag gcctggcaag cgggtgaaga caagagatct tccaggctct     2820

cagagccctg ggagggcgat ttccaggaag accacaatgc caacctctgg aggaggctgg     2880

agagagaagg cctaggccag agcctgtcag gcaactttgg caagaccaag tcagccttct     2940

catctctcca gaacattcct gagagtctga gaagacacag cagcctggag ctaggccggg     3000

gaacccagga gggttacccc gggggcaggc ccacctgtgc agtcaacacc aaggcagaag     3060

accctgggag gaaagccgct cctgacctcg ggagccatct ggaccggcag gtttcctacc     3120

cgcggcccga ggggaggacc ggtgcctcgg cttctttcaa cagcacagac ccaagtcccg     3180

aagagccgcc tgccccctcg cacccgcaca catccagtct gggccggagg gggcccggcc     3240

caggcagcgc ctcggctctt cagggctttc agtacgggaa gccccactgc tcggtgctgg     3300

agaaggtctc caaattcgag cagcgagagc aagggagcca gagaccgagt gtgggcggct     3360

ctggttttgg ccataactat aggccccaca ggaccgtctc aacttccagt acttctggga     3420

atgacttcga ggagacaaaa gcacacattc gtttctctga gtcagctgaa cccctaggca     3480

acggggagca gcacttcaaa aacggggagc tgaagttgga agaggcttcc cggcagccct     3540

gcggtcagca gctgagcgga ggagcgtcgg acagcggccg tggcccccag aggccggacg     3600

ctcggctcct ccgtagccag agcaccttcc agctctccag cgagccagag agggagcccg     3660

agtggcggga caggcccggc tcgcccgaat cgcccctgct ggatgccccc ttcagccgcg     3720

cctaccggaa cagcatcaag gacgcacagt cccgtgtctt gggggccacc tcctttcgac     3780

gtcgagacct ggagctgggg gcgcccgtgg cgtcgaggtc ctggcggcca cggccttcct     3840

cggcccacgt ggggctgcgg agccccgagg cgtcggcctc cgcctccccg cacacgcccc     3900

gggagcggca cagcgtgacc cctgctgagg gcgacctggc caggcccgtg ccccctgccg     3960

cccggagagg tgctcgccgg cgcctgactc ccgagcagaa gaagcgctcc tactcggagc     4020

ccgagaagat gaacgaggtg gggatcgtgg aggaggccga accggcaccc ctgggcccgc     4080

agagaaatgg gatgcgtttc ccggagagca gcgtggccga ccggcgccgt ctcttcgagc     4140

gcgatggcaa ggcctgctcc acgctcagcc tgtcggggcc cgagctgaag cagttccagc     4200

agagcgccct ggcggactac atccagcgca agaccggcaa gcggcctacc tccgccgccg     4260

gctgcagcct ccaggagccc gggccactgc gtgagcgcgc ccagagtgcc tacctccagc     4320

ccggccccgc ggcgctcgaa ggctccggcc tcgcctcggc ctccagcttg agctcactgc     4380

gggagcccag cctgcagccc cgcagggagg ccacgctcct gccggccaca gttgcagaaa     4440

cccagcaggc tccccgagat cgcagcagct ccttcgccgg tggccgccgc ctcggggaac     4500

ggcgacgcgg ggacctgctt agcggagcaa acggtggaac aaggggcacc cagagagggg     4560

atgagacccc cagggagcca tcctcctggg gggccagggc cgggaagtcc atgtcggccg     4620

aggacctgct ggaacgctcg gacgtccttg cgggccctgt ccatgtgagg tccaggtcat     4680

ctcccgccac cgcagacaag cgccaggatg tgcttttggg gcaagacagt ggctttggtc     4740

ttgtgaagga tccatgttat ttggctggtc ctggatctag gtcactcagt tgttcagaaa     4800

gaggccaaga agagatgctg ccgctcttcc accatctcac ccctcgttgg ggtggttcag     4860

gctgcaaagc cattggtgat tcctccgttc ctagtgaatg tcctggaacc ctggaccatc     4920

agaggcaagc cagtaggaca ccctgcccca ggccaccact ggcaggaacg caagggctgg     4980

tcacagacac cagggctgca cccctgaccc caattggcac ccctctgcct tcagccattc     5040

cctctggcta ctgctcacag gacggtcaga cagggcgaca gcctctcccg ccctacaccc     5100

ctgccatgat gcacagaagc aatggtcaca ccctgaccca gcctcccggt ccaagaggct     5160

gtgagggcga tggcccagag catggggtag aagagggaac gaggaagagg gtctcgctgc     5220

ctcagtggcc acctccttct cgagcaaagt gggcccacgc agccagagag gacagccttc     5280

ctgaggaatc ctcagcccct gattttgcaa acctgaagca ctatcaaaaa cagcagagtc     5340

ttccaagttt atgcagcact tctgacccag acacacctct tggggccccg agcactccag     5400

ggaggatctc cctccgaata tctgagtctg tcctgcggga ctccccgcca cctcatgagg     5460

attatgaaga cgaagtgttt gtgagggatc cgcaccccaa ggccacgtcc agccccacat     5520

ttgaacctct tcccccaccc ccacctcctc caccgagtca ggaaaccccg gtgtatagca     5580

tggatgactt ccctccacct cctccccaca ctgtatgtga ggcgcagctg gacagtgagg     5640

atcccgaggg gccacgcccc agcttcaaca aactttctaa agtgacaatt gcaagggaaa     5700

ggcacatgcc tggtgcagcc catgtggtag gtagtcagac actggcttcc agactccaaa     5760

cttctatcaa gggttcagag gctgagtcca caccaccctc cttcatgagc gttcacgccc     5820

aacttgctgg gtctcttggt gggcagccag cacccatcca gactcaaagc ctcagccatg     5880

atccagtcag tggaactcag ggtttagaaa agaaagtcag tcctgatcct cagaagagtt     5940

cagaagacat cagaacagag gctttggcca aggaaattgt ccaccaagac aaatctctag     6000

cagacatttt ggatccagac tccaggctga agacaacaat ggacctgatg gaaggtttgt     6060

ttccccgaga tgtgaacttg ctgaaggaaa acagtgtaaa gaggaaggcc atacagagaa     6120

ctgtcagctc ttcaggatgt gaaggcaaga ggaatgaaga caaggaagca gtgagcatgt     6180

tggttaactg ccctgcctac tacagtgtgt ctgctcccaa ggctgagcta ctgaacaaaa     6240

tcaaagagat gccagcagaa gtgaatgagg aagaggaaca ggcagatgtc aatgaaaaga     6300

aggctgagct cattggaagt ctcacccaca agctggagac cctccaggag gcgaagggga     6360

gcctgctcac ggacatcaag ctcaacaacg ccctgggaga agaggtggag gctctgatca     6420

gcgagctctg caagcccaat gagtttgaca agtataggat gttcataggg gatttggaca     6480

aggtggtcaa cctgctgctc tccctctcgg ggcgtctagc ccgtgttgag aatgtcctta     6540

gcggccttgg tgaagatgcc agtaatgaag aaaggagctc tctttacgag aaaaggaaga     6600

tcctggctgg tcagcatgag gatgcccggg agctgaagga gaacctggat cgcagggagc     6660

gagtagtgct gggcatcttg gccaattacc tttcagagga gcagctccag gactaccagc     6720

acttcgtgaa aatgaagtcc acgctcctca ttgagcaacg gaagctggat gacaagatca     6780

agctgggcca ggagcaggtc aagtgtctgc tggagagcct gccctcagat ttcattccca     6840

aggctggggc cctggctctg cccccaaacc tcacgagtga gcccattcct gctgggggct     6900

gtactttcag tggtattttc ccaacattaa cctctccact ttaacctctt ctaaaatacc     6960

caaccaaaag atcactgttt ctctcaacac tatttaatct gaaaaatgtt tcagtacaaa     7020

ccactgtttg aactatctgg gttattggtg tttgttcctg atgaaaggaa aaaaattctc     7080

tccaggagga agcctttttc cttcttgccc ttcctgattg atcttctgag agctcgaatg     7140

ctgctggaca cgtacccctt tctattatta ctttgtagta gaaagaaagt taatgaaact     7200

gagaactgat tggagggtgt ttgatcattt agtttttaac aggctgaggc aacatggatc     7260

agtgtgtgtc cccctcagga atgtatccac agtggccttc cttgctggtg ggcagtgtat     7320

cctgatggca gggtacaagt accattaatg aagggtctgc aacataaagc cttaaaaaga     7380

cacacactaa gaaaactgta aaaccttgaa cattgttatt tatatttttt aaaatggaaa     7440

agatcactat gtttgttgtg ctaaccactt atttgattct gttttgtggt ggacatagat     7500

gattacgttt gagctttgta ttttgtgaaa accttaatga aatgaattcc aaagatagtc     7560

acgttgagcg tgaagacttt ttttcttaca ttcctgtctt atttttacca acacgagcag     7620

gcattctgcg cttccactgg actgagtatg ggggagtcct gctcccctcc tgtctcacac     7680

cttccccagg aggaaggcct catgcactgc ggttattgca tcatttccta gtgcttcatg     7740

tcattatcac tggtggggaa acaaagctaa attttattaa caaagacaac tctcagacct     7800

atataatagg aggaggacgt ccagaatcca acaaaattca aacggagccc atgctgttct     7860

cctgaacaag atttgggcta aatacggcct gtttattgag gctgttttaa tgatgcttta     7920

aaaaaaaaaa atgttttcta aaatgtcaaa cctgttgacc acactttgat taaaaactgc     7980

ctccttaacc tctgaagact gattttgctt tatcatgttt caataataac atttcagagg     8040

ttactctgta gccccagttg taagcttata aaaacaaact ggaaggctga ggaggttatg     8100

ggctggcagc caggctatgt ttacagctgc tggagatggc agtagcctta tactttgagc     8160

aggtagtaca tcccaggctg tgctagaggt agatttgttt tttcacgttt gatctgtggc     8220

tggtggccac ctttgttgat ttgggcttac gagtttcata gtagccagtc ttagaaaatt     8280

gggggagtaa aattttgaag taaaaaaaaa aaaaaaatga caagggaacc aaatgctcct     8340

tctcccctta gtacattttc attacttaat gaagttttat ctcctatgta agaatatcaa     8400

aattgtagtt tgggtctcca gtagagatgt cttttgatta acttataaac aactggccac     8460

ccagaagttt cctttgcata gtcaaccaaa gctatggctt tgttctttgg agcttatata     8520

ctgcatgact ccattgatac aaataagaca gcaccttggt ttcccaggga tgttttcatt     8580

cagaggtcct gtctcccagg aaagcagtag aaccagtgac agcattcaac agccacactg     8640

catggtcatc agtcttaggc caacatggga gcctgaaatt aactccatca gtaactacct     8700

gtgtgtcttg ctgatactga atgagccctc acaagccaag ccaggtggaa gacagccagc     8760

aaacgtctac agttattctt agtgaaattc ctcagaggaa tccagggggc tcccagttcc     8820

caacactctt cgagatgacc atttttcggg atttgactgg ggaacatttt acatattcag     8880

tctttctcaa aaatttttat ttattttctt gagaaagggt cttactatgt tgcccaggct     8940

ggagtgcaga gtggtgcgat aacagctcat tgcagtctga acctctgagg ctcaagccat     9000

cctcccatct cagcctccca agtagctggg accacaggtg tgcaccacta tgcttggcta     9060

attttttgat tttttataga gacgggggtc tcgctatgtt gcccaggctg gtttcaaact     9120

cctgggctca agggatcctt ccgctttggt cccagaagtg ctgggattac aggcatgagc     9180

cacttcaccc agccactttt ctaatttata gacataaaag taattgactc ccacagcaca     9240

gtaacaggca atgctgcttg gcatgccaca aacatctgaa agcttgtgac actcctagga     9300

ttgtgtccat tctttcatta tgtggaaact ttgttctgtt atgtgaaatg ggtaaggcac     9360

caagtgagac tttgaaatct aatttttagg tggatgtgat atttattgta ataggacttg     9420

acctctgtac tttaaagaaa tcactaacca aattttcaaa gtttcctttt aaatgcgttt     9480

agctagaaat ctatgtattt atccctttcc tattttgcat tcttctccca ctatttttaa     9540

aaactcattt acagtagaaa ccattcttct ttctcccaac agtatccttt gccaagacca     9600

tgagaacagt aaggagcatg ttgttggtca gggtttcaga atacgcgtga tgtcactgag     9660

aatgtttgct cacagtcaat aattgtcttt gtggatgtga taattttgga gatacacttc     9720

tggtcagaac tcaggtgaga taatcttgca atactccaaa tgcagatact ccagccaccc     9780

gcaaggttcc aggaaaggac aatgtcctgc gagaaaatca ggaggcctcc acttcctggg     9840

ccacttgaga agttcctggg catgtcacta catgttggtt gactcagcca tttctcatgc     9900

tgttttgttt cttgcggtgg ccacttaacc ccaaagaatg aagggaggat ccacagtgaa     9960

agtgcctgag tttctctatg agaccagatg ctgtcgaaac caaacatctt ttcctttgct    10020

ctatgggaac attttagggt ttgttttgca cagctggttt ccagactaga agattaacaa    10080

gtttgggtcc acccctaaga atcagtggct gtcttttaag gtgaggagtg tgggcttaac    10140

tgaggtcctt tgagggagct ataaaggaga aacaacctgg gacatcccag ttttcctatt    10200

cctccactgt taatatctca tctaaaataa ttcatgagtt taaatggtaa atatatgctt    10260

taagctctac ctttaaactt gtatgttatt caggcatctc ttattaagat actgggtctc    10320

tggataccca aggaaatgtt ggctttttat tcttatgtgg ttccaaattt acttctcttc    10380

agtttaattg tccatggtag tgctggcttc attgttaggt tggagttatt attttccttt    10440

tagaacaaca tgaattttat tcaccttact attagaaaaa ggaataacta cagccagaaa    10500

taacttcatt tcctacaagg tataaaaagt ggtcaagtga atgtgaaggg gcttttctac    10560

acaggaatat attatcggga acaaagtatt tcctgctgcc ttaactcttt gggatgcata    10620

ggataaaatg ataaagacca ttttaatatc agaaagggtt gtcttattaa tttttaaata    10680

aaacttcaca tttcttaatg gggagctcat tcagaaacta aataatggtt tctcaaagtg    10740

tggtcaggat acgatctgca tcagaatcct tggaatgctt gttaaaaata ccaattgcta    10800

tgacaaaacc aagtctgctg gaaactgcat ttcagcaggt ttcccatgtt attctgatgt    10860

attttaacat ttgagagcca ctaccaatca tctgtacagt tcctactgtt atgatcacaa    10920

taagactaac atgaatttaa taatctgaat aatttttaaa atttaaataa acagaaattg    10980

aagttaaatt taaaaataaa aataacctca gaagttgaaa aaa                      11023


<210>  68
<211>  1996
<212>  PRT
<213>  homo sapiens

<400>  68

Met Met Arg Thr Thr Glu Asp Phe His Lys Pro Ser Ala Thr Leu Asn 
1               5                   10                  15      


Ser Asn Thr Ala Thr Lys Gly Arg Tyr Ile Tyr Leu Glu Ala Phe Leu 
            20                  25                  30          


Glu Gly Gly Ala Pro Trp Gly Phe Thr Leu Lys Gly Gly Leu Glu His 
        35                  40                  45              


Gly Glu Pro Leu Ile Ile Ser Lys Val Glu Glu Gly Gly Lys Ala Asp 
    50                  55                  60                  


Thr Leu Ser Ser Lys Leu Gln Ala Gly Asp Glu Val Val His Ile Asn 
65                  70                  75                  80  


Glu Val Thr Leu Ser Ser Ser Arg Lys Glu Ala Val Ser Leu Val Lys 
                85                  90                  95      


Gly Ser Tyr Lys Thr Leu Arg Leu Val Val Arg Arg Asp Val Cys Thr 
            100                 105                 110         


Asp Pro Gly His Ala Asp Thr Gly Ala Ser Asn Phe Val Ser Pro Glu 
        115                 120                 125             


His Leu Thr Ser Gly Pro Gln His Arg Lys Ala Ala Trp Ser Gly Gly 
    130                 135                 140                 


Val Lys Leu Arg Leu Lys His Arg Arg Ser Glu Pro Ala Gly Arg Pro 
145                 150                 155                 160 


His Ser Trp His Thr Thr Lys Ser Gly Glu Lys Gln Pro Asp Ala Ser 
                165                 170                 175     


Met Met Gln Ile Ser Gln Gly Met Ile Gly Pro Pro Trp His Gln Ser 
            180                 185                 190         


Tyr His Ser Ser Ser Ser Thr Ser Asp Leu Ser Asn Tyr Asp His Ala 
        195                 200                 205             


Tyr Leu Arg Arg Ser Pro Asp Gln Cys Ser Ser Gln Gly Ser Met Glu 
    210                 215                 220                 


Ser Leu Glu Pro Ser Gly Ala Tyr Pro Pro Cys His Leu Ser Pro Ala 
225                 230                 235                 240 


Lys Ser Thr Gly Ser Ile Asp Gln Leu Ser His Phe His Asn Lys Arg 
                245                 250                 255     


Asp Ser Ala Tyr Ser Ser Phe Ser Thr Ser Ser Ser Ile Leu Glu Tyr 
            260                 265                 270         


Pro His Pro Gly Ile Ser Gly Arg Glu Arg Ser Gly Ser Met Asp Asn 
        275                 280                 285             


Thr Ser Ala Arg Gly Gly Leu Leu Glu Gly Met Arg Gln Ala Asp Ile 
    290                 295                 300                 


Arg Tyr Val Lys Thr Val Tyr Asp Thr Arg Arg Gly Val Ser Ala Glu 
305                 310                 315                 320 


Tyr Glu Val Asn Ser Ser Ala Leu Leu Leu Gln Gly Arg Glu Ala Arg 
                325                 330                 335     


Ala Ser Ala Asn Gly Gln Gly Tyr Asp Lys Trp Ser Asn Ile Pro Arg 
            340                 345                 350         


Gly Lys Gly Val Pro Pro Pro Ser Trp Ser Gln Gln Cys Pro Ser Ser 
        355                 360                 365             


Leu Glu Thr Ala Thr Asp Asn Leu Pro Pro Lys Val Gly Ala Pro Leu 
    370                 375                 380                 


Pro Pro Ala Arg Ser Asp Ser Tyr Ala Ala Phe Arg His Arg Glu Arg 
385                 390                 395                 400 


Pro Ser Ser Trp Ser Ser Leu Asp Gln Lys Arg Leu Cys Arg Pro Gln 
                405                 410                 415     


Ala Asn Ser Leu Gly Ser Leu Lys Ser Pro Phe Ile Glu Glu Gln Leu 
            420                 425                 430         


His Thr Val Leu Glu Lys Ser Pro Glu Asn Ser Pro Pro Val Lys Pro 
        435                 440                 445             


Lys His Asn Tyr Thr Gln Lys Ala Gln Pro Gly Gln Pro Leu Leu Pro 
    450                 455                 460                 


Thr Ser Ile Tyr Pro Val Pro Ser Leu Glu Pro His Phe Ala Gln Val 
465                 470                 475                 480 


Pro Gln Pro Ser Val Ser Ser Asn Gly Met Leu Tyr Pro Ala Leu Ala 
                485                 490                 495     


Lys Glu Ser Gly Tyr Ile Ala Pro Gln Gly Ala Cys Asn Lys Met Ala 
            500                 505                 510         


Thr Ile Asp Glu Asn Gly Asn Gln Asn Gly Ser Gly Arg Pro Gly Phe 
        515                 520                 525             


Ala Phe Cys Gln Pro Leu Glu His Asp Leu Leu Ser Pro Val Glu Lys 
    530                 535                 540                 


Lys Pro Glu Ala Thr Ala Lys Tyr Val Pro Ser Lys Val His Phe Cys 
545                 550                 555                 560 


Ser Val Pro Glu Asn Glu Glu Asp Ala Ser Leu Lys Arg His Leu Thr 
                565                 570                 575     


Pro Pro Gln Gly Asn Ser Pro His Ser Asn Glu Arg Lys Ser Thr His 
            580                 585                 590         


Ser Asn Lys Pro Ser Ser His Pro His Ser Leu Lys Cys Pro Gln Ala 
        595                 600                 605             


Gln Ala Trp Gln Ala Gly Glu Asp Lys Arg Ser Ser Arg Leu Ser Glu 
    610                 615                 620                 


Pro Trp Glu Gly Asp Phe Gln Glu Asp His Asn Ala Asn Leu Trp Arg 
625                 630                 635                 640 


Arg Leu Glu Arg Glu Gly Leu Gly Gln Ser Leu Ser Gly Asn Phe Gly 
                645                 650                 655     


Lys Thr Lys Ser Ala Phe Ser Ser Leu Gln Asn Ile Pro Glu Ser Leu 
            660                 665                 670         


Arg Arg His Ser Ser Leu Glu Leu Gly Arg Gly Thr Gln Glu Gly Tyr 
        675                 680                 685             


Pro Gly Gly Arg Pro Thr Cys Ala Val Asn Thr Lys Ala Glu Asp Pro 
    690                 695                 700                 


Gly Arg Lys Ala Ala Pro Asp Leu Gly Ser His Leu Asp Arg Gln Val 
705                 710                 715                 720 


Ser Tyr Pro Arg Pro Glu Gly Arg Thr Gly Ala Ser Ala Ser Phe Asn 
                725                 730                 735     


Ser Thr Asp Pro Ser Pro Glu Glu Pro Pro Ala Pro Ser His Pro His 
            740                 745                 750         


Thr Ser Ser Leu Gly Arg Arg Gly Pro Gly Pro Gly Ser Ala Ser Ala 
        755                 760                 765             


Leu Gln Gly Phe Gln Tyr Gly Lys Pro His Cys Ser Val Leu Glu Lys 
    770                 775                 780                 


Val Ser Lys Phe Glu Gln Arg Glu Gln Gly Ser Gln Arg Pro Ser Val 
785                 790                 795                 800 


Gly Gly Ser Gly Phe Gly His Asn Tyr Arg Pro His Arg Thr Val Ser 
                805                 810                 815     


Thr Ser Ser Thr Ser Gly Asn Asp Phe Glu Glu Thr Lys Ala His Ile 
            820                 825                 830         


Arg Phe Ser Glu Ser Ala Glu Pro Leu Gly Asn Gly Glu Gln His Phe 
        835                 840                 845             


Lys Asn Gly Glu Leu Lys Leu Glu Glu Ala Ser Arg Gln Pro Cys Gly 
    850                 855                 860                 


Gln Gln Leu Ser Gly Gly Ala Ser Asp Ser Gly Arg Gly Pro Gln Arg 
865                 870                 875                 880 


Pro Asp Ala Arg Leu Leu Arg Ser Gln Ser Thr Phe Gln Leu Ser Ser 
                885                 890                 895     


Glu Pro Glu Arg Glu Pro Glu Trp Arg Asp Arg Pro Gly Ser Pro Glu 
            900                 905                 910         


Ser Pro Leu Leu Asp Ala Pro Phe Ser Arg Ala Tyr Arg Asn Ser Ile 
        915                 920                 925             


Lys Asp Ala Gln Ser Arg Val Leu Gly Ala Thr Ser Phe Arg Arg Arg 
    930                 935                 940                 


Asp Leu Glu Leu Gly Ala Pro Val Ala Ser Arg Ser Trp Arg Pro Arg 
945                 950                 955                 960 


Pro Ser Ser Ala His Val Gly Leu Arg Ser Pro Glu Ala Ser Ala Ser 
                965                 970                 975     


Ala Ser Pro His Thr Pro Arg Glu Arg His Ser Val Thr Pro Ala Glu 
            980                 985                 990         


Gly Asp Leu Ala Arg Pro Val Pro  Pro Ala Ala Arg Arg  Gly Ala Arg 
        995                 1000                 1005             


Arg Arg  Leu Thr Pro Glu Gln  Lys Lys Arg Ser Tyr  Ser Glu Pro 
    1010                 1015                 1020             


Glu Lys  Met Asn Glu Val Gly  Ile Val Glu Glu Ala  Glu Pro Ala 
    1025                 1030                 1035             


Pro Leu  Gly Pro Gln Arg Asn  Gly Met Arg Phe Pro  Glu Ser Ser 
    1040                 1045                 1050             


Val Ala  Asp Arg Arg Arg Leu  Phe Glu Arg Asp Gly  Lys Ala Cys 
    1055                 1060                 1065             


Ser Thr  Leu Ser Leu Ser Gly  Pro Glu Leu Lys Gln  Phe Gln Gln 
    1070                 1075                 1080             


Ser Ala  Leu Ala Asp Tyr Ile  Gln Arg Lys Thr Gly  Lys Arg Pro 
    1085                 1090                 1095             


Thr Ser  Ala Ala Gly Cys Ser  Leu Gln Glu Pro Gly  Pro Leu Arg 
    1100                 1105                 1110             


Glu Arg  Ala Gln Ser Ala Tyr  Leu Gln Pro Gly Pro  Ala Ala Leu 
    1115                 1120                 1125             


Glu Gly  Ser Gly Leu Ala Ser  Ala Ser Ser Leu Ser  Ser Leu Arg 
    1130                 1135                 1140             


Glu Pro  Ser Leu Gln Pro Arg  Arg Glu Ala Thr Leu  Leu Pro Ala 
    1145                 1150                 1155             


Thr Val  Ala Glu Thr Gln Gln  Ala Pro Arg Asp Arg  Ser Ser Ser 
    1160                 1165                 1170             


Phe Ala  Gly Gly Arg Arg Leu  Gly Glu Arg Arg Arg  Gly Asp Leu 
    1175                 1180                 1185             


Leu Ser  Gly Ala Asn Gly Gly  Thr Arg Gly Thr Gln  Arg Gly Asp 
    1190                 1195                 1200             


Glu Thr  Pro Arg Glu Pro Ser  Ser Trp Gly Ala Arg  Ala Gly Lys 
    1205                 1210                 1215             


Ser Met  Ser Ala Glu Asp Leu  Leu Glu Arg Ser Asp  Val Leu Ala 
    1220                 1225                 1230             


Gly Pro  Val His Val Arg Ser  Arg Ser Ser Pro Ala  Thr Ala Asp 
    1235                 1240                 1245             


Lys Arg  Gln Asp Val Leu Leu  Gly Gln Asp Ser Gly  Phe Gly Leu 
    1250                 1255                 1260             


Val Lys  Asp Pro Cys Tyr Leu  Ala Gly Pro Gly Ser  Arg Ser Leu 
    1265                 1270                 1275             


Ser Cys  Ser Glu Arg Gly Gln  Glu Glu Met Leu Pro  Leu Phe His 
    1280                 1285                 1290             


His Leu  Thr Pro Arg Trp Gly  Gly Ser Gly Cys Lys  Ala Ile Gly 
    1295                 1300                 1305             


Asp Ser  Ser Val Pro Ser Glu  Cys Pro Gly Thr Leu  Asp His Gln 
    1310                 1315                 1320             


Arg Gln  Ala Ser Arg Thr Pro  Cys Pro Arg Pro Pro  Leu Ala Gly 
    1325                 1330                 1335             


Thr Gln  Gly Leu Val Thr Asp  Thr Arg Ala Ala Pro  Leu Thr Pro 
    1340                 1345                 1350             


Ile Gly  Thr Pro Leu Pro Ser  Ala Ile Pro Ser Gly  Tyr Cys Ser 
    1355                 1360                 1365             


Gln Asp  Gly Gln Thr Gly Arg  Gln Pro Leu Pro Pro  Tyr Thr Pro 
    1370                 1375                 1380             


Ala Met  Met His Arg Ser Asn  Gly His Thr Leu Thr  Gln Pro Pro 
    1385                 1390                 1395             


Gly Pro  Arg Gly Cys Glu Gly  Asp Gly Pro Glu His  Gly Val Glu 
    1400                 1405                 1410             


Glu Gly  Thr Arg Lys Arg Val  Ser Leu Pro Gln Trp  Pro Pro Pro 
    1415                 1420                 1425             


Ser Arg  Ala Lys Trp Ala His  Ala Ala Arg Glu Asp  Ser Leu Pro 
    1430                 1435                 1440             


Glu Glu  Ser Ser Ala Pro Asp  Phe Ala Asn Leu Lys  His Tyr Gln 
    1445                 1450                 1455             


Lys Gln  Gln Ser Leu Pro Ser  Leu Cys Ser Thr Ser  Asp Pro Asp 
    1460                 1465                 1470             


Thr Pro  Leu Gly Ala Pro Ser  Thr Pro Gly Arg Ile  Ser Leu Arg 
    1475                 1480                 1485             


Ile Ser  Glu Ser Val Leu Arg  Asp Ser Pro Pro Pro  His Glu Asp 
    1490                 1495                 1500             


Tyr Glu  Asp Glu Val Phe Val  Arg Asp Pro His Pro  Lys Ala Thr 
    1505                 1510                 1515             


Ser Ser  Pro Thr Phe Glu Pro  Leu Pro Pro Pro Pro  Pro Pro Pro 
    1520                 1525                 1530             


Pro Ser  Gln Glu Thr Pro Val  Tyr Ser Met Asp Asp  Phe Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro His Thr Val Cys  Glu Ala Gln Leu Asp  Ser Glu Asp 
    1550                 1555                 1560             


Pro Glu  Gly Pro Arg Pro Ser  Phe Asn Lys Leu Ser  Lys Val Thr 
    1565                 1570                 1575             


Ile Ala  Arg Glu Arg His Met  Pro Gly Ala Ala His  Val Val Gly 
    1580                 1585                 1590             


Ser Gln  Thr Leu Ala Ser Arg  Leu Gln Thr Ser Ile  Lys Gly Ser 
    1595                 1600                 1605             


Glu Ala  Glu Ser Thr Pro Pro  Ser Phe Met Ser Val  His Ala Gln 
    1610                 1615                 1620             


Leu Ala  Gly Ser Leu Gly Gly  Gln Pro Ala Pro Ile  Gln Thr Gln 
    1625                 1630                 1635             


Ser Leu  Ser His Asp Pro Val  Ser Gly Thr Gln Gly  Leu Glu Lys 
    1640                 1645                 1650             


Lys Val  Ser Pro Asp Pro Gln  Lys Ser Ser Glu Asp  Ile Arg Thr 
    1655                 1660                 1665             


Glu Ala  Leu Ala Lys Glu Ile  Val His Gln Asp Lys  Ser Leu Ala 
    1670                 1675                 1680             


Asp Ile  Leu Asp Pro Asp Ser  Arg Leu Lys Thr Thr  Met Asp Leu 
    1685                 1690                 1695             


Met Glu  Gly Leu Phe Pro Arg  Asp Val Asn Leu Leu  Lys Glu Asn 
    1700                 1705                 1710             


Ser Val  Lys Arg Lys Ala Ile  Gln Arg Thr Val Ser  Ser Ser Gly 
    1715                 1720                 1725             


Cys Glu  Gly Lys Arg Asn Glu  Asp Lys Glu Ala Val  Ser Met Leu 
    1730                 1735                 1740             


Val Asn  Cys Pro Ala Tyr Tyr  Ser Val Ser Ala Pro  Lys Ala Glu 
    1745                 1750                 1755             


Leu Leu  Asn Lys Ile Lys Glu  Met Pro Ala Glu Val  Asn Glu Glu 
    1760                 1765                 1770             


Glu Glu  Gln Ala Asp Val Asn  Glu Lys Lys Ala Glu  Leu Ile Gly 
    1775                 1780                 1785             


Ser Leu  Thr His Lys Leu Glu  Thr Leu Gln Glu Ala  Lys Gly Ser 
    1790                 1795                 1800             


Leu Leu  Thr Asp Ile Lys Leu  Asn Asn Ala Leu Gly  Glu Glu Val 
    1805                 1810                 1815             


Glu Ala  Leu Ile Ser Glu Leu  Cys Lys Pro Asn Glu  Phe Asp Lys 
    1820                 1825                 1830             


Tyr Arg  Met Phe Ile Gly Asp  Leu Asp Lys Val Val  Asn Leu Leu 
    1835                 1840                 1845             


Leu Ser  Leu Ser Gly Arg Leu  Ala Arg Val Glu Asn  Val Leu Ser 
    1850                 1855                 1860             


Gly Leu  Gly Glu Asp Ala Ser  Asn Glu Glu Arg Ser  Ser Leu Tyr 
    1865                 1870                 1875             


Glu Lys  Arg Lys Ile Leu Ala  Gly Gln His Glu Asp  Ala Arg Glu 
    1880                 1885                 1890             


Leu Lys  Glu Asn Leu Asp Arg  Arg Glu Arg Val Val  Leu Gly Ile 
    1895                 1900                 1905             


Leu Ala  Asn Tyr Leu Ser Glu  Glu Gln Leu Gln Asp  Tyr Gln His 
    1910                 1915                 1920             


Phe Val  Lys Met Lys Ser Thr  Leu Leu Ile Glu Gln  Arg Lys Leu 
    1925                 1930                 1935             


Asp Asp  Lys Ile Lys Leu Gly  Gln Glu Gln Val Lys  Cys Leu Leu 
    1940                 1945                 1950             


Glu Ser  Leu Pro Ser Asp Phe  Ile Pro Lys Ala Gly  Ala Leu Ala 
    1955                 1960                 1965             


Leu Pro  Pro Asn Leu Thr Ser  Glu Pro Ile Pro Ala  Gly Gly Cys 
    1970                 1975                 1980             


Thr Phe  Ser Gly Ile Phe Pro  Thr Leu Thr Ser Pro  Leu 
    1985                 1990                 1995     


<210>  69
<211>  3216
<212>  DNA
<213>  homo sapiens

<400>  69
gggcgcgcgg ctgcagcggc ggagccggag tcggagccgg gagcgctagc ggcagccgga       60

tcgcagcctg cggggcccgc cgcagccatg ggcaaccgcg gcatggaaga tctcatcccg      120

ctggtcaacc ggctgcaaga cgccttctct gccatcggcc agaacgcgga cctcgacctg      180

ccgcagatcg ctgtggtggg cggccagagc gccggcaaga gctcggtgct cgagaatttc      240

gtaggcaggg acttcttgcc tcgaggatct ggcattgtca cccgacgtcc cctggtcttg      300

cagctggtca atgcaaccac agaatatgcc gagttcctgc actgcaaggg aaagaaattc      360

accgacttcg aggaggtgcg ccttgagatc gaggccgaga ccgacagggt caccggcacc      420

aacaagggca tctcgccggt gcctatcaac ctccgcgtct actcgccgca cgtgctgaac      480

ctgaccctgg tggacctgcc cggaatgacc aaggtcccgg tgggggacca acctcccgac      540

atcgagttcc agatccgaga catgcttatg cagtttgtca ccaaggagaa ctgcctcatc      600

ctggccgtgt cccccgccaa ctctgacctg gccaattctg acgccctcaa ggtcgccaag      660

gaggtggacc cccagggcca gcgcaccatc ggggtcatca ccaagctgga cctgatggac      720

gagggcacag atgcccgtga tgtgctggag aacaagctgc tccccctgcg cagaggctac      780

attggagtgg tgaaccggag ccagaaggac attgatggca agaaggacat taccgccgcc      840

ttggctgctg aacgaaagtt cttcctctcc catccatctt atcgccactt ggctgaccgt      900

atgggcacgc cctacctgca gaaggtcctc aatcagcaac tgacgaacca catccgggac      960

acactgccgg ggctgcggaa caagctgcag agccagctac tgtccattga gaaggaggtg     1020

gaggaataca agaacttccg ccctgatgac ccagctcgca agaccaaggc cctgctgcag     1080

atggtccagc agttcgccgt agactttgag aagcgcattg agggctcagg agatcagatc     1140

gacacctacg aactgtcagg gggagcccgc attaaccgaa tcttccacga gcgcttccct     1200

ttcgagctgg tcaagatgga gtttgatgag aaggaactcc gaagggagat cagctatgct     1260

atcaagaata tccatggcat tagaacgggg ctgtttaccc cagacatggc ctttgagacc     1320

attgtgaaaa agcaggtgaa gaagatccga gaaccgtgtc tcaagtgtgt ggacatggtt     1380

atctcggagc taatcagcac cgttagacag tgcaccaaga agctccagca gtacccgcgg     1440

ctacgggagg agatggagcg catcgtgacc acccacatcc gggagcgcga gggccgcact     1500

aaggagcagg tcatgcttct catcgatatc gagctggctt acatgaacac caaccatgag     1560

gacttcatag gctttgccaa tgctcagcag aggagcaacc agatgaacaa gaagaagact     1620

tcagggaacc aggatgagat tctggtcatc cgcaagggct ggctgactat caataatatt     1680

ggcatcatga aagggggctc caaggagtac tggtttgtgc tgactgctga gaatctgtcc     1740

tggtacaagg atgatgagga gaaagagaag aaatacatgc tgtctgtgga caacctcaag     1800

ctgcgggacg tggagaaggg ctttatgtcg agcaagcata tctttgccct ctttaacacg     1860

gagcagagga atgtctacaa ggattatcgg cagctggagc tagcctgtga gacacaggag     1920

gaggtggaca gctggaaggc ctccttcctg agggctggcg tgtaccctga gcgtgttggg     1980

gacaaagaga aagccagcga gaccgaggag aatggctccg acagcttcat gcattccatg     2040

gacccacagc tggaacggca agtggagacc atccggaatc ttgtggactc atacatggcc     2100

attgtcaaca agaccgtgag ggacctcatg cccaagacca tcatgcacct catgattaac     2160

aataccaagg agttcatctt ctcggagctg ctggccaacc tgtactcgtg tggggaccag     2220

aacacgctga tggaggagtc ggcggagcag gcacagcggc gcgacgagat gctgcgcatg     2280

taccacgcac tgaaggaggc gctcagcatc atcggcgaca tcaacacgac caccgtcagc     2340

acgcccatgc ccccgcccgt ggacgactcc tggctgcagg tgcagagcgt accggccgga     2400

cgcaggtcgc ccacgtccag ccccacgccg cagcgccgag cccccgccgt gcccccagcc     2460

cggcccgggt cgcggggccc tgctcctggg cctccgcctg ctgggtccgc cctggggggg     2520

gcgccccccg tgccctccag gccgggggct tcccctgacc ctttcggccc tccccctcag     2580

gtgccctcgc gccccaaccg cgccccgccc ggggtcccca gccgatcggg tcaggcaagt     2640

ccatcccgtc ctgagagccc caggcccccc ttcgacctct aaacagatcc ctcctcttct     2700

cggagacctc cctttccaag cctgcctgga cggctgttct gtgacttgac agtggctccc     2760

ccagccccaa agccagcccc cttcatctgt gacttaatct gttgtagtgg tgagctgata     2820

cattcaggtg tgaccgttgg tgaaaacttg tgccccttct gtggtatgcc cttgccctgt     2880

tctataaata tctataaata ctcatatata tacacaccta cacatggcca accgcctcgc     2940

ctctagcgct gggaatcagt cactgtgcta tccttgtgga gtcttgtggc ccaactacca     3000

gagaacgctg tcccccgaca tcccactcca aagtgtgcca cctccagtga gcctccttgt     3060

catgcccggc ctgtggacag ccagcccccg ccatccctcc caccccctac caagcatggg     3120

ggtgctgtgc aggcagccgt gtggcctgac agtttctacc agtcctgctg tccctcggct     3180

gagaataaaa cccatttctg gatgatgggg aatgtc                               3216


<210>  70
<211>  864
<212>  PRT
<213>  homo sapiens

<400>  70

Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu 
145                 150                 155                 160 


Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro 
                165                 170                 175     


Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp 
            340                 345                 350         


Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln 
                405                 410                 415     


Val Lys Lys Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile 
            420                 425                 430         


Ser Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Leu Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser 
            500                 505                 510         


Gly Asn Gln Asp Glu Ile Leu Val Ile Arg Lys Gly Trp Leu Thr Ile 
        515                 520                 525             


Asn Asn Ile Gly Ile Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
    530                 535                 540                 


Leu Thr Ala Glu Asn Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Tyr Met Leu Ser Val Asp Asn Leu Lys Leu Arg Asp Val Glu 
                565                 570                 575     


Lys Gly Phe Met Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu 
            580                 585                 590         


Gln Arg Asn Val Tyr Lys Asp Tyr Arg Gln Leu Glu Leu Ala Cys Glu 
        595                 600                 605             


Thr Gln Glu Glu Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
    610                 615                 620                 


Val Tyr Pro Glu Arg Val Gly Asp Lys Glu Lys Ala Ser Glu Thr Glu 
625                 630                 635                 640 


Glu Asn Gly Ser Asp Ser Phe Met His Ser Met Asp Pro Gln Leu Glu 
                645                 650                 655     


Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ala Ile 
            660                 665                 670         


Val Asn Lys Thr Val Arg Asp Leu Met Pro Lys Thr Ile Met His Leu 
        675                 680                 685             


Met Ile Asn Asn Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ala Asn 
    690                 695                 700                 


Leu Tyr Ser Cys Gly Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu 
705                 710                 715                 720 


Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr His Ala Leu Lys 
                725                 730                 735     


Glu Ala Leu Ser Ile Ile Gly Asp Ile Asn Thr Thr Thr Val Ser Thr 
            740                 745                 750         


Pro Met Pro Pro Pro Val Asp Asp Ser Trp Leu Gln Val Gln Ser Val 
        755                 760                 765             


Pro Ala Gly Arg Arg Ser Pro Thr Ser Ser Pro Thr Pro Gln Arg Arg 
    770                 775                 780                 


Ala Pro Ala Val Pro Pro Ala Arg Pro Gly Ser Arg Gly Pro Ala Pro 
785                 790                 795                 800 


Gly Pro Pro Pro Ala Gly Ser Ala Leu Gly Gly Ala Pro Pro Val Pro 
                805                 810                 815     


Ser Arg Pro Gly Ala Ser Pro Asp Pro Phe Gly Pro Pro Pro Gln Val 
            820                 825                 830         


Pro Ser Arg Pro Asn Arg Ala Pro Pro Gly Val Pro Ser Arg Ser Gly 
        835                 840                 845             


Gln Ala Ser Pro Ser Arg Pro Glu Ser Pro Arg Pro Pro Phe Asp Leu 
    850                 855                 860                 


<210>  71
<211>  2105
<212>  DNA
<213>  homo sapiens

<400>  71
agactccgcc caagcatgca cacacacagg cttgatgctc gctcccgttt ctacaggagg       60

ttttgacggc tggatgctgc agggcatccc ctcgcctgga ggaggttcac ttgtggccag      120

gttcccagca cacccacttg ctcactgggg ccctggggac accgccacac tcgagcccat      180

cctacggcct caatccttac cagtccccag gccatggact gccacactgt aggtcttcaa      240

tcaaggttca gtggagtttc gaatgtacac acaccctgaa agacagcgcg gccacctcag      300

aaaacaacgc gcgcccagct ggctcccctc cgacagggcc cacggctact gggtcggcct      360

cctccggacc ctgagcacag cctggtatgc gtgcgggctc ggaatacgga tctgagcaga      420

agaaatgcga gtggagagcg gttctgcgca ggaaagagga attttgttgg aaagcctgtc      480

gacgttgcta gaaaagacca cagcatctca cgaggggcgt gcgccgggaa accgggagtt      540

gacggacctc ctgccccccg aggtctgcag tctcctgaac ccagcagcca tctacgccaa      600

caacgagatc agcctgcgtg acgttgaggt ctacggcttt gactacgact acaccctggc      660

ccagtatgca gacgcactgc accccgagat cttcagtacc gcccgtgaca tcctgatcga      720

gcactacaag tacccagaag ggattcggaa gtatgactac aaccccagct ttgccatccg      780

tggcctccac tatgacattc agaagagcct tctgatgaag attgacgcct tccactacgt      840

gcagctgggg acagcctaca ggggcctcca gcctgtgcca gacgaggagg tgattgagct      900

gtatgggggt acccagcaca tcccactata ccagatgagt ggcttctatg gcaagggtcc      960

ctccattaag cagttcatgg acatcttctc gctaccggag atggctctgc tgtcctgtgt     1020

ggtggactac tttctgggcc acagcctgga gtttgaccaa gcacatctct acaaggacgt     1080

gacggacgcc atccgagacg tgcatgtgaa gggcctcatg taccagtgga tcgagcagga     1140

catggagaag tacatcctga gaggggatga gacgtttgct gtcctgagcc gcctggtggc     1200

ccatgggaaa cagctgttcc tcatcaccaa cagtcctttc agcttcgtag acaaggggat     1260

gcggcacatg gtgggtcccg attggcgcca gctcttcgat gtggtcattg tccaggcaga     1320

caagcccagc ttcttcactg accggcgcaa gcctttcaga aaactcgatg agaagggctc     1380

acttcagtgg gaccggatca cccgcttgga aaagggcaag atctatcggc agggaaacct     1440

gtttgacttc ttacgcttga cggaatggcg tggcccccgc gtgctctact tcggggacca     1500

cctctatagt gatctggcgg atctcatgct gcggcacggc tggcgcacag gcgccatcat     1560

ccccgagctg gagcgtgaga tccgcatcat caacacggag cagtacatgc actcgctgac     1620

gtggcagcag gcgctcacgg ggctgctgga gcgcatgcag acctatcagg acgcggagtc     1680

gaggcaggtg ctggctgcct ggatgaaaga gcggcaggag ctgaggtgca tcaccaaggc     1740

cctgttcaat gcgcagttcg gcagcatctt ccgcaccttc cacaacccca cctacttctc     1800

aaggcgcctc gtgcgcttct ctgacctcta catggcctcc ctcagctgcc tgctcaacta     1860

ccgcgtggac ttcaccttct acccacgccg tacgccgctg cagcacgagg cacccctctg     1920

gatggaccag ctctgcaccg gctgcatgaa gacccccttc cttggtgaca tggcccacat     1980

ccgctgaggg cacctttatt gtctgggaca ggccctcagc ccctcctgcc ccatccaccc     2040

agacaagcaa taaaagtggt ctcctccctg tgcatgcttc tgctttcaaa aaaaaaaaaa     2100

aaaaa                                                                 2105


<210>  72
<211>  520
<212>  PRT
<213>  homo sapiens

<400>  72

Met Arg Val Glu Ser Gly Ser Ala Gln Glu Arg Gly Ile Leu Leu Glu 
1               5                   10                  15      


Ser Leu Ser Thr Leu Leu Glu Lys Thr Thr Ala Ser His Glu Gly Arg 
            20                  25                  30          


Ala Pro Gly Asn Arg Glu Leu Thr Asp Leu Leu Pro Pro Glu Val Cys 
        35                  40                  45              


Ser Leu Leu Asn Pro Ala Ala Ile Tyr Ala Asn Asn Glu Ile Ser Leu 
    50                  55                  60                  


Arg Asp Val Glu Val Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Ala Gln 
65                  70                  75                  80  


Tyr Ala Asp Ala Leu His Pro Glu Ile Phe Ser Thr Ala Arg Asp Ile 
                85                  90                  95      


Leu Ile Glu His Tyr Lys Tyr Pro Glu Gly Ile Arg Lys Tyr Asp Tyr 
            100                 105                 110         


Asn Pro Ser Phe Ala Ile Arg Gly Leu His Tyr Asp Ile Gln Lys Ser 
        115                 120                 125             


Leu Leu Met Lys Ile Asp Ala Phe His Tyr Val Gln Leu Gly Thr Ala 
    130                 135                 140                 


Tyr Arg Gly Leu Gln Pro Val Pro Asp Glu Glu Val Ile Glu Leu Tyr 
145                 150                 155                 160 


Gly Gly Thr Gln His Ile Pro Leu Tyr Gln Met Ser Gly Phe Tyr Gly 
                165                 170                 175     


Lys Gly Pro Ser Ile Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu 
            180                 185                 190         


Met Ala Leu Leu Ser Cys Val Val Asp Tyr Phe Leu Gly His Ser Leu 
        195                 200                 205             


Glu Phe Asp Gln Ala His Leu Tyr Lys Asp Val Thr Asp Ala Ile Arg 
    210                 215                 220                 


Asp Val His Val Lys Gly Leu Met Tyr Gln Trp Ile Glu Gln Asp Met 
225                 230                 235                 240 


Glu Lys Tyr Ile Leu Arg Gly Asp Glu Thr Phe Ala Val Leu Ser Arg 
                245                 250                 255     


Leu Val Ala His Gly Lys Gln Leu Phe Leu Ile Thr Asn Ser Pro Phe 
            260                 265                 270         


Ser Phe Val Asp Lys Gly Met Arg His Met Val Gly Pro Asp Trp Arg 
        275                 280                 285             


Gln Leu Phe Asp Val Val Ile Val Gln Ala Asp Lys Pro Ser Phe Phe 
    290                 295                 300                 


Thr Asp Arg Arg Lys Pro Phe Arg Lys Leu Asp Glu Lys Gly Ser Leu 
305                 310                 315                 320 


Gln Trp Asp Arg Ile Thr Arg Leu Glu Lys Gly Lys Ile Tyr Arg Gln 
                325                 330                 335     


Gly Asn Leu Phe Asp Phe Leu Arg Leu Thr Glu Trp Arg Gly Pro Arg 
            340                 345                 350         


Val Leu Tyr Phe Gly Asp His Leu Tyr Ser Asp Leu Ala Asp Leu Met 
        355                 360                 365             


Leu Arg His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Glu Arg 
    370                 375                 380                 


Glu Ile Arg Ile Ile Asn Thr Glu Gln Tyr Met His Ser Leu Thr Trp 
385                 390                 395                 400 


Gln Gln Ala Leu Thr Gly Leu Leu Glu Arg Met Gln Thr Tyr Gln Asp 
                405                 410                 415     


Ala Glu Ser Arg Gln Val Leu Ala Ala Trp Met Lys Glu Arg Gln Glu 
            420                 425                 430         


Leu Arg Cys Ile Thr Lys Ala Leu Phe Asn Ala Gln Phe Gly Ser Ile 
        435                 440                 445             


Phe Arg Thr Phe His Asn Pro Thr Tyr Phe Ser Arg Arg Leu Val Arg 
    450                 455                 460                 


Phe Ser Asp Leu Tyr Met Ala Ser Leu Ser Cys Leu Leu Asn Tyr Arg 
465                 470                 475                 480 


Val Asp Phe Thr Phe Tyr Pro Arg Arg Thr Pro Leu Gln His Glu Ala 
                485                 490                 495     


Pro Leu Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe 
            500                 505                 510         


Leu Gly Asp Met Ala His Ile Arg 
        515                 520 


<210>  73
<211>  733
<212>  DNA
<213>  homo sapiens

<400>  73
aaacagcagg aaatagaaac ttaagagaaa tacacacttc tgagaaactg aaacgacagg       60

ggaaaggagg tctcactgag caccgtccca gcatccggac accacagcgg cccttcgctc      120

cacgcagaaa accacacttc tcaaaccttc actcaacact tccttcccca aagccagaag      180

atgcacaagg aggaacatga ggtggctgtg ctgggggcac cccccagcac catccttcca      240

aggtccaccg tgatcaacat ccacagcgag acctccgtgc ccgaccatgt cgtctggtcc      300

ctgttcaaca ccctcttctt gaactggtgc tgtctgggct tcatagcatt cgcctactcc      360

gtgaagtcta gggacaggaa gatggttggc gacgtgaccg gggcccaggc ctatgcctcc      420

accgccaagt gcctgaacat ctgggccctg attctgggca tcctcatgac cattggattc      480

atcctgttac tggtattcgg ctctgtgaca gtctaccata ttatgttaca gataatacag      540

gaaaaacggg gttactagta gccgcccata gcctgcaacc tttgcactcc actgtgcaat      600

gctggccctg cacgctgggg ctgttgcccc tgcccccttg gtcctgcccc tagatacagc      660

agtttatacc cacacacctg tctacagtgt cattcaataa agtgcacgtg cttgtgaaaa      720

aaaaaaaaaa aaa                                                         733


<210>  74
<211>  125
<212>  PRT
<213>  homo sapiens

<400>  74

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  75
<211>  1743
<212>  DNA
<213>  homo sapiens

<400>  75
gtgcgcgggg gcccgaccac cgcggggccg ggacgcgatg gcggcggcag agcccgcgag       60

ctcgggccag caggcgccgg cagggcaggg gcagggccag cggccgccgc cgcagcctcc      120

gcaggcgcaa gccccgcagc cgcccccgcc gccgcagctc gggggcgccg ggggcggcag      180

cagcaggcac gagaagagcc tggggctgct cactaccaag ttcgtgtcgc tgctgcagga      240

ggccaaggac ggcgttctgg atctcaaagc ggctgctgat actttggctg tgaggcaaaa      300

aaggagaatt tatgatatca ccaatgtctt agagggaatt gacttgattg aaaaaaagtc      360

aaaaaacagt atccagtgga aaggtgtagg tgctggctgt aatactaaag aagtcataga      420

tagattaaga tatcttaaag ctgaaattga agatctagaa ctgaaggaaa gagaacttga      480

tcagcagaag ttgtggctac agcaaagcat caaaaatgtg atggacgatt ccattaataa      540

tagattttcc tatgtaactc atgaagacat ctgtaattgc tttaatggtg atacactttt      600

ggccattcag gcaccttctg gtacacaact ggaggtaccc attccagaaa tgggtcagaa      660

tggacaaaag aaataccaga tcaatctaaa gagtcattca ggacctatcc atgtgctgct      720

tataaataaa gagtcgagtt catctaagcc cgtggttttt cctgttcccc cacctgatga      780

cctcacacag ccttcctccc agtccttgac tccagtgact ccacagaaat ccagcatggc      840

aactcaaaat ctgcctgagc aacatgtctc tgaaagaagc caggctctgc agcagacatc      900

agctacagat atatcttcag caggatctat tagtggagat atcattgatg agttaatgtc      960

ttctgacgtg tttcctctct taaggctttc tcctaccccg gcagatgact acaactttaa     1020

tttagatgat aacgaaggag tttgtgatct gtttgatgtc cagatactaa attattagat     1080

tccatggaaa cttgggactg ttatctacct ctaactgtgt aacattttag acttcttaat     1140

aacctaaata tttaaaataa tgaatgtaac acctttttta gttcactgat tctgaagtgt     1200

tcttccctaa tactttcttt acttcacaaa acttcaacca taaaaacaaa gggctctgat     1260

tgctttaggg gataagtgat ttaatatcca caaacgtccc cactcccaaa agtaactata     1320

ttctggattt caacttttct tctaattgtg aatccttctg ttttttcttc ttaaggagga     1380

aagttaaagg acactacagg tcatcaaaaa caagttggcc aaggactcat tacttgtctt     1440

atatttttac tgccactaaa ctgcctgtat ttctgtatgt ccttctatcc aaacagacgt     1500

tcactgccac ttgtaaagtg aaggatgtaa acgaggatat ataactgttt cagtgaacag     1560

attttgtgaa gtgccttctg ttttagcact ttaagtttat cacattttgt tgacttctga     1620

cattccactt tcctaggtta taggaaagat ctgtttatgt agtttgtttt taaaatgtgc     1680

caatgcctgt acattaacaa gatttttaaa aataaaattg tataaaacat tcaaaaaaaa     1740

aaa                                                                   1743


<210>  76
<211>  346
<212>  PRT
<213>  homo sapiens

<400>  76

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Ala Gly Ser Ile Ser Gly Asp Ile Ile Asp 
    290                 295                 300                 


Glu Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr 
305                 310                 315                 320 


Pro Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys 
                325                 330                 335     


Asp Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345     


<210>  77
<211>  1754
<212>  DNA
<213>  homo sapiens

<400>  77
tggagcagcg gggcctggca cacagtaggc gttctataaa tgtgtcacaa gaatggcttc       60

cctcaggaag gcggcattac cgctgccttt ctgcagaaaa ggaaactaag gctcagcaag      120

aaccaccgcc cagccagagc caaggtcaca gagcacgtcc gtggcacgcg tccaggtcgt      180

gccacagcag ggccggcggc ttcgacgcgg gcagccgggt cccttttctt tgacagatgg      240

ggaaaccgag gcccggccgg ctgccggggc tcctcgcacc taccccagca actcaaattc      300

accacctcgg actcctgcga ccgcatcaaa gacgaatttc agctactgca agctcagtac      360

cacagcctca agctcgaatg tgacaagttg gccagtgaga agtcagagat gcagcgtcac      420

tatgtgatgt actacgagat gtcctacggc ttgaacatcg agatgcacaa acaggctgag      480

atcgtcaaaa ggctgaacgg gatttgtgcc caggtcctgc cctacctctc ccaagagcac      540

cagcagcagg tcttgggagc cattgagagg gccaagcagg tcaccgctcc cgagctgaac      600

tctatcatcc gacagcagct ccaagcccac cagctgtccc agctgcaggc cctggccctg      660

cccttgaccc cactacccgt ggggctgcag ccgccttcgc tgccggcggt cagcgcaggc      720

accggcctcc tctcgctgtc cgcgctgggt tcccaggccc acctctccaa ggaagacaag      780

aacgggcacg atggtgacac ccaccaggag gatgatggcg agaagtcgga ttagcagggg      840

gccgggacag ggaggttggg aggggggaca gaggggagac agaggcacgg agagaaagga      900

atgtttagca caagacacag cggagctcgg gattggctaa actcccatag tatttatggt      960

ggccgccggc gggggcccca gcccagcttg caggccacct ctagctttct tcctacccca     1020

ttcccggctt ccctcctcct cccctgcagc ctggttaggt ggatacctgc cctgacatgt     1080

gaggcaagct aaggcctgga gggtcagatg ggagaccagg tcccaaggga gcaagacctc     1140

gcgaagcgca gcagccccgg cccttccccc gttttgaaca tgtgtaaccg acagtctgcc     1200

tgggccacag ccctctcacc ctggtactgc atgcacgcaa tgctagctgc ccctttcccg     1260

tcctgggcac cccgagtctc ccccgacccc gggtcccagg tatgctccca cctccacctg     1320

ccccactcac cacctctgct agttccagac acctccacgc ccacctggtc ctctcccatc     1380

gcccacaaaa gggggggcac gagggacgag cttagctgag ctgggaggag cagggtgagg     1440

gtgggcgacc caggattccc cctccccttc ccaaataaag atgagggtac taaagttgtc     1500

ttggttttta ttttattatt atttttttct ttttccagta tactagcttg tcttttaaga     1560

aaggggatat taaaaaaaaa aaaagacaaa agtgttttta aaaaaaagca acacccacac     1620

ctgtgtctgt atatagtcag cttatctcgt gttcaatcgt ctgatctcta cagagagaag     1680

tggaaaatgc tgtatcaagg gtgggcttag ctgtgccttt ccaataaaga tgtgagaagc     1740

ttcaaaaaaa aaaa                                                       1754


<210>  78
<211>  264
<212>  PRT
<213>  homo sapiens

<400>  78

Met Cys His Lys Asn Gly Phe Pro Gln Glu Gly Gly Ile Thr Ala Ala 
1               5                   10                  15      


Phe Leu Gln Lys Arg Lys Leu Arg Leu Ser Lys Asn His Arg Pro Ala 
            20                  25                  30          


Arg Ala Lys Val Thr Glu His Val Arg Gly Thr Arg Pro Gly Arg Ala 
        35                  40                  45              


Thr Ala Gly Pro Ala Ala Ser Thr Arg Ala Ala Gly Ser Leu Phe Phe 
    50                  55                  60                  


Asp Arg Trp Gly Asn Arg Gly Pro Ala Gly Cys Arg Gly Ser Ser His 
65                  70                  75                  80  


Leu Pro Gln Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile 
                85                  90                  95      


Lys Asp Glu Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu 
            100                 105                 110         


Glu Cys Asp Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr 
        115                 120                 125             


Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys 
    130                 135                 140                 


Gln Ala Glu Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu 
145                 150                 155                 160 


Pro Tyr Leu Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu 
                165                 170                 175     


Arg Ala Lys Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln 
            180                 185                 190         


Gln Leu Gln Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro 
        195                 200                 205             


Leu Thr Pro Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val 
    210                 215                 220                 


Ser Ala Gly Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala 
225                 230                 235                 240 


His Leu Ser Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln 
                245                 250                 255     


Glu Asp Asp Gly Glu Lys Ser Asp 
            260                 


<210>  79
<211>  3748
<212>  DNA
<213>  homo sapiens

<400>  79
agtgacgcga gacgcggggt gtggctctgc cggcccaggc gcgatgaggc ggctgcccgc       60

tgggtggcgc cgatttcccg gggaggtccc ttctgggccc ccggcggagg tgggagagag      120

tcaggcagga gccgaggccg gggagccctc ttcgtcagct ggtgctcact gcgccgcgcc      180

agcgccagcc gggactcacc cgcagctcca tgcttgtgcc cggttcgact cgtccatact      240

ccaagaagag gcagcccatg aggctcccag tccccactga gtgccaccct gaaggatgtc      300

ccagctctcc tccaccctga agcgctacac agaatcggcc cgctacacag atgcccacta      360

tgccaagtcg ggctatggtg cctacacccc gtcctcctat ggggccaatc tggctgcctc      420

cttactggag aaggagaaac ttggtttcaa gccggtcccc accagcagct tcctcacccg      480

tccccgtacc tatggcccct cctccctcct ggactatgac cggggccgcc ccctgctgag      540

acccgacatc actgggggtg gtaagcgggc agagagccag acccggggta ctgagcggcc      600

tttaggcagt ggcctcagcg ggggcagcgg attcccttat ggagtgacca acaactgcct      660

cagctacctg cccatcaatg cctatgacca gggggtgacc ctaacccaga agctggacag      720

ccaatcagac ctggcccggg atttctccag cctccggacc tcagatagct accggataga      780

ccccaggaac ctgggccgca gccccatgct ggcccggacg cgcaaggagc tctgcaccct      840

gcaggggctc taccagacag ccagctgccc tgaatacctg gtcgactacc tggagaacta      900

tggtcgcaag ggcagtgcat ctcaggtgcc ctcccaggcc cctccctcac gagtccctga      960

aatcatcagc ccaacctacc gacccattgg ccgctacacg ctgtgggaga cgggaaaggg     1020

tcaggcccct gggcccagcc gctccagctc cccgggaaga gacggcatga attctaagag     1080

tgcccagggt ctggctggtc ttcgaaacct tgggaacacg tgcttcatga actcaattct     1140

gcagtgcctg agcaacactc gggagttgag agattactgc ctccagaggc tctacatgcg     1200

ggacctgcac cacggcagca atgcacacac agccctcgtg gaagagtttg caaaactaat     1260

tcagaccata tggacttcat cccccaatga tgtggtgagc ccatctgagt tcaagaccca     1320

gatccagaga tacgcaccgc gctttgttgg ctataatcag caggatgctc aggagttcct     1380

tcgctttctt ctggatgggc tccataacga ggtgaaccga gtgacactga gacctaagtc     1440

caaccctgag aacctcgatc atcttcctga tgacgagaaa ggccgacaga tgtggagaaa     1500

atatctagaa cgggaagaca gtaggatcgg ggatctcttt gttgggcagc taaagagctc     1560

gctgacgtgt acagattgtg gttactgttc tacggtcttc gaccccttct gggacctctc     1620

actgcccatt gctaagcgag gttatcctga ggtgacatta atggactgca tgaggctctt     1680

caccaaagag gatgtgcttg atggagatga aaagccaaca tgctgtcgct gccgaggcag     1740

aaaacggtgt ataaagaagt tctccatcca gaggttccca aagatcttgg tgctccatct     1800

gaagcggttc tcagaatcca ggatccgaac cagcaagctc acaacatttg tgaacttccc     1860

cctaagagac ctggacttaa gagaatttgc ctcagaaaac accaaccatg ctgtttacaa     1920

cctgtacgct gtgtccaatc actccggaac caccatgggt ggccactata cagcctactg     1980

tcgcagtcca gggacaggag aatggcacac tttcaacgac tccagcgtca ctcccatgtc     2040

ctccagccaa gtgcgcacca gcgacgccta cctgctcttc tacgaactgg ccagcccgcc     2100

ctcccgaatg tagcgccagg agccacgtcc cttctccctt ccccgtggtg gccccgctcc     2160

ctaaattttt taaaaagaca aaaacaaaac aacaacaaca acacacaaac ctgacaagag     2220

aaaaacaaac ctgaagctgc cgagcaggag tggatgcagc ctgatcaggg tctggagcaa     2280

ggagccgggc tttcctgagc tgtggcccgg cagggaagat cgcctggacg tggagccagc     2340

atcgccccgt gccctcggcg tttgcatttg taaacttgtg gtcttcctat gtgtcagaaa     2400

caactgtgtc ttggggggga agaccctcgc tgcgccgctt cccgccgcag cgcccgcgcc     2460

tccgagggga cagcgccctc tggagctcgc tgggagcatc accgcctgga cgcccgcgcc     2520

gcggaggagc cggcgcccat ctccacccgc acggctcgcc ggtccagagc catgagccaa     2580

gagccctctt cacgctgcta actccagggg acagacgaag ggacatcttt ggaaaacgct     2640

ggttttggtt tttaaaaagc ccaacttttt ttttttaatt tccataacta aagtgttcag     2700

actggagtgc tctccttcag gcctcttcat agctgggacg ttgcactggt ccttttattg     2760

cttttccaag tacaactttc taatgctagc cctccgtggt gctaggtggg cgttggccag     2820

gccccaagca cagccacagt agacctggga tctaaaacaa gtttctgttt tgggggtttg     2880

ggtttttttt tttttttttt aatgttttga atggaattta gttgcctcca agaattgtgc     2940

cttatagcat ttggggacca gggggtaact gcccctcctg aaatatccct cagcctcttc     3000

ccttttcccc agtgctctgt tcaaacccgc ctgggaaagg gatcctgccc ttagccctgg     3060

ctcgttgtgc attgcagtga ggcaaagaag aaagcaggta gattccttcc gacagggcat     3120

caagttcttc ccgcccacgt cctctagccc acccctggtc tgctccccag ctgtttgaag     3180

gatagcacaa gcccctcgtc cctagagctt ctctcccttt tatttattct cttaacatcc     3240

ctttccccct ggccttcctg cccccgcccc cttctcagag cctcctagac aataggccct     3300

ttggaccgag tttctcaggg atgcccaggc cacccctcag ctcttcttag cgctggtctc     3360

cagtcctgcc ctgggagctg gagcctgggt atttggggac atcttgcctc agttgtatgg     3420

ttctttcctg tgggctcaat tttgccctac atagttggat aaaactctgt gctgtcctgg     3480

agagtaaagc tgttcaccca cacagctggg cccggcttgt gccccgtgga gcctggcaca     3540

ttccaggctc ctaggaggag gcatcagaga aagacaccct gagttttact ggcctgacac     3600

ccttctccag agaagacctg tgaacctgag cccaagggca agtgtacact tgtttactgt     3660

gtaagcaaga gtagaagaat gtctaatgta cagtggaacc ttgtacagaa taaataatag     3720

ctttgagaaa tcaaaaaaaa aaaaaaaa                                        3748


<210>  80
<211>  605
<212>  PRT
<213>  homo sapiens

<400>  80

Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ala Arg 
1               5                   10                  15      


Tyr Thr Asp Ala His Tyr Ala Lys Ser Gly Tyr Gly Ala Tyr Thr Pro 
            20                  25                  30          


Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Leu Leu Glu Lys Glu Lys 
        35                  40                  45              


Leu Gly Phe Lys Pro Val Pro Thr Ser Ser Phe Leu Thr Arg Pro Arg 
    50                  55                  60                  


Thr Tyr Gly Pro Ser Ser Leu Leu Asp Tyr Asp Arg Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Thr Gly Gly Gly Lys Arg Ala Glu Ser Gln Thr 
                85                  90                  95      


Arg Gly Thr Glu Arg Pro Leu Gly Ser Gly Leu Ser Gly Gly Ser Gly 
            100                 105                 110         


Phe Pro Tyr Gly Val Thr Asn Asn Cys Leu Ser Tyr Leu Pro Ile Asn 
        115                 120                 125             


Ala Tyr Asp Gln Gly Val Thr Leu Thr Gln Lys Leu Asp Ser Gln Ser 
    130                 135                 140                 


Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr Arg 
145                 150                 155                 160 


Ile Asp Pro Arg Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg 
                165                 170                 175     


Lys Glu Leu Cys Thr Leu Gln Gly Leu Tyr Gln Thr Ala Ser Cys Pro 
            180                 185                 190         


Glu Tyr Leu Val Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala 
        195                 200                 205             


Ser Gln Val Pro Ser Gln Ala Pro Pro Ser Arg Val Pro Glu Ile Ile 
    210                 215                 220                 


Ser Pro Thr Tyr Arg Pro Ile Gly Arg Tyr Thr Leu Trp Glu Thr Gly 
225                 230                 235                 240 


Lys Gly Gln Ala Pro Gly Pro Ser Arg Ser Ser Ser Pro Gly Arg Asp 
                245                 250                 255     


Gly Met Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu 
            260                 265                 270         


Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr 
        275                 280                 285             


Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu 
    290                 295                 300                 


His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys 
305                 310                 315                 320 


Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro 
                325                 330                 335     


Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly 
            340                 345                 350         


Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly 
        355                 360                 365             


Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro 
    370                 375                 380                 


Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp 
385                 390                 395                 400 


Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val 
                405                 410                 415     


Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser 
            420                 425                 430         


Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg 
        435                 440                 445             


Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys 
    450                 455                 460                 


Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg 
465                 470                 475                 480 


Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys 
                485                 490                 495     


Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr 
            500                 505                 510         


Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu 
        515                 520                 525             


Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr 
    530                 535                 540                 


Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala 
545                 550                 555                 560 


Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser 
                565                 570                 575     


Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr 
            580                 585                 590         


Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        595                 600                 605 


<210>  81
<211>  2042
<212>  RNA
<213>  homo sapiens

<400>  81
agcacccaag ggcggcaacc aagcgggggg aaccaccagc aagcaggcca gggaggcgca       60

gcaggacgcg cagaccccgg agaaaaaaaa acaacgggcg gaggacgaca ggagagagac      120

ggggaagaag gcggcaaggc ccaagaagag agaggcgggc agcgccccca ggccggccag      180

gcgcccgacg gcccacacgg gccccagccc ccgccgggcg gaaggcgaca accgcgaaaa      240

ggaggggacc cccggcgggg gccggggaca cacaccccaa agcgaaacag gcccgggccg      300

gccgaagggc gcaacccccc ccggcgcccc accggccccg cgcgcccccc cgcgcccgag      360

ccgagccaag cagcgccggg gagcgcgcag gccaccagga ccgccgcccg ccgcggccgc      420

gcccacgccg ccaggccgag ccagccgggg cgccgcggac ggaccggaac cgggcgagac      480

agggagcgaa ggccagggcg cgccaacccg acgcgggcgc cgggccccag ccgcgcggcg      540

ccgccgccag cccacccccc aaccccccaa aacaagccca aggcggccga ggggcggaca      600

cccagcggcc gggcaagagg gggggacacc cgcccacccg agcgacccgc cgagagaacg      660

agggcacacg ccggcccgag caacccacag accagccacc ggccggcccg ccagcgaagc      720

ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccacgcgc gcagccccgc      780

ccgcgcccag aggcggccgg ccagcggcgg ggggcgcagg cacacgaggg ggcggaccgc      840

cggaacacac gggcgcccgg ccgggacggg ggcccccgca cggacaccca cgcaaccaca      900

ggaaccgaag acgggcaaag ccccggccgg gcaaacggga gacaagccca gcccggcgag      960

aacgcaaccc ggcaacagcc acacaaccaa acgagacccc gagggagcaa gccccccacc     1020

agccccccgg acaccagaaa aggggggcgg gggggaaaga accagggacg ggaaacaaaa     1080

caggaaaaca cagacaccac aagggcacaa acgggcgcac acgcggaggg cgggaaaggg     1140

gcaggccaga gcacccgcag agccagaaca gcgagagagc ggaggcaccc agccaccaac     1200

ccccccgccc gacaaagggg gaggcaaagc ccagagacag cgacaaaggc acacagcaag     1260

cagggggagc agagcggagg gaccgcccca gccagggccc cccacaccac aggccccgag     1320

gccccgccag gggagggcga gcccaacggc aagggaacaa gaccgaaccg ggaacggccc     1380

agagcccgag gaggaagaaa aagaagagaa cgccggcaga gcaaagaaac aaacagacaa     1440

acaagccaaa agaagaccaa aaaaaagaag gggagcaacc cggaaaagaa ccccaccaaa     1500

gaaaaccgga aaccccaggg aggcggaagc ccccagcccg cagcagaggg gcccagaaag     1560

aggacaggca ccccacaaaa gaagagcaca ggaggaaaca aggccccgaa ccgaagagaa     1620

caaacagccg ggacacgaga caacgaaaga caagggagag cccccacaca gcccggcccg     1680

ccaacagcag aacagggaga ggcagaccga cccaaggagg cgagagccca aacgcgccca     1740

aacagcaccc gcaaggagga caagcaagcc gcccaggaga gaaaaaacaa gagaaaggaa     1800

aaagaaccac caaaccacca ggaaaacccg aaagggacac ccgaacacac aacagaaaaa     1860

gccaaaaggg gacagcgaga gggcaagaaa aacagagcac ccaagggaaa cagcaccgaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2040

aa                                                                    2042


<210>  82
<211>  5125
<212>  DNA
<213>  homo sapiens

<400>  82
cgagactcag ccagaggagt acggattaag tggccgaaga aagaggagtg aggcagggga       60

gcgaggcgga cgctccgagc gcatcggact cacctgggcc ggcggcgacc ggcgagtacg      120

agtggactct tgccctccgc agcatgcgcc ccgcctgcta agtcgccgcc gtctcgccct      180

cacctagcac cgccaatccc gcctggatgg agtcccctct gggttcccat tggctcctgt      240

gagtgcttgg gtgtcgggag cctgtttttg gcgaggggaa ccaacttttg aagttcgccc      300

agaagactgc gttccagccc cagttccccg gcagcgggac ccggcgaaga cgcgaccgcg      360

gcgcgagtca ccatgggaag caaaggtgtc taccagtacc actggcaaag ccacaatgtc      420

aagcacagtg gtgtggacga catggtgcta ctgtccaaga tcacagagaa ctccatcgtg      480

gagaatctga agaagagata catggatgac tacattttta catatatagg atctgtatta      540

atctcagtca accctttcaa gcagatgcca tattttgggg aaaaggaaat tgaaatgtac      600

caaggagcgg cacagtatga aaacccacca catatctatg cccttgcaga taatatgtac      660

agaaacatga tcattgacag agagaaccag tgcgtcatta tcagtggtga aagtggtgct      720

ggaaaaacag tggctgccaa atatatcatg agctacatct ccagagtgtc tggaggaggg      780

accaaagtcc agcacgtgaa ggacattatc ctgcagtcca acccgctgct ggaggccttc      840

gggaacgcca agaccgtccg gaacaacaac tccagccgat ttggaaaata ctttgaaatc      900

cagttcagtc caggtgggga accagatggt ggaaagatct ccaacttcct tctggaaaaa      960

tctagggtgg tgatgaggaa cccaggagag cggagttttc acatatttta ccagctcatc     1020

gagggcgcct ctgcagagca gaaacacagc cttggcatca ccagcatgga ctattattac     1080

tacctgagcc tctcgggctc atacaaggtt gatgacattg acgacaggcg ggagtttcag     1140

gaaactctgc acgccatgaa tgtgattggg atctttgcag aagagcaaac gctggtgttg     1200

cagatagtgg cgggtattct ccacctggga aacatcagct tcaaagaagt tggcaactac     1260

gcggctgtgg agagtgaaga gtttttagct tttcctgcat atctgctagg gataaaccag     1320

gaccggttga aagaaaagct aacaagccgg cagatggata gcaagtgggg aggcaaatcc     1380

gaatccatcc acgtgaccct caacgtagag caggcctgtt acacccggga tgcgctcgcc     1440

aaggccctgc acgcccgggt ctttgatttc ttggtagatt ccatcaataa agccatggag     1500

aaagaccatg aagaatacaa cattggcgtc ctagacatct atggctttga aatattccag     1560

aaaaatggct ttgaacagtt ttgtatcaat tttgttaatg aaaaactgca gcagattttt     1620

attgaactga cattaaaggc agaacaggaa gaatatgttc aagagggaat aagatggaca     1680

cccattgagt actttaataa taaaatcgta tgtgacctca tagagaacaa agtgaaccct     1740

cctggcatca tgagcatcct ggatgacgtg tgcgccacga tgcatgcggt gggtgagggg     1800

gcagatcaga cgctgctcca gaaacttcag atgcagattg ggagtcatga gcacttcaac     1860

agttggaacc aaggcttcat cattcatcat tatgctggga aggtatccta tgacatggat     1920

ggcttttgtg aaaggaaccg ggatgtgctt tttatggatc tcatcgagct tatgcagagc     1980

agcgagctgc ctttcataaa gtctttattt ccggaaaatc tgcaggctga caagaaaggg     2040

cgcccaacta ctgccggaag caaaataaag aaacaagcca atgaccttgt gagcaccctg     2100

atgaaatgta cgccccacta cattcgctgc atcaagccaa acgaaaccaa gaagcccaga     2160

gactgggagg aaagcagggt aaagcatcaa gtcgaatatt tgggtctgaa agagaacatt     2220

cgagtgagaa gagctggcta tgcctatcgg cgcatcttcc aaaaattcct acagaggtat     2280

gccattctga ccaaagccac ctggccttct tggcagggag aggagaagca aggcgtcctg     2340

cacctgctgc agtcggtcaa catggacagc gaccagttcc agctggggag gagtaaagtg     2400

ttcatcaaag cccccgagtc tctatttctt ttagaagaga tgagagagag aaagtatgat     2460

gggtatgctc gagtgataca gaaatcatgg aggaaattcg tggcccggaa gaaatacgtt     2520

caaatgagag aagaagcctc agacctctta ttgaacaaga aggagagaag gagaaacagt     2580

attaacagga actttatagg ggattatatt gggatggaag agcacccaga actccagcag     2640

ttcgtgggca agagggagaa gattgatttc gcagacacag tcaccaagta tgacaggagg     2700

ttcaagggtg taaagcgaga cctgctcctt accccaaagt gcttgtactt aatcggacga     2760

gaaaaagtca aacagggccc agacaagggc ctggtgaaag aagtcctgaa gcggaaaatc     2820

gagatagaac ggatcttgtc tgtgtccctc agtactatgc aggatgacat ttttattctc     2880

catgagcaag agtatgacag tttgcttgaa tctgtcttca aaactgaatt cctaagcctc     2940

ttagcaaagc gttacgagga gaagacccag aagcaactac ctctgaaatt cagcaatacg     3000

cttgaactga agttgaaaaa ggaaaactgg ggcccctgga gtgcaggggg ctcccggcaa     3060

gtgcagttcc accaagggtt tggggacctg gctgtcctca agcccagtaa caaagtgctg     3120

caggtcagca tcggacctgg actgcccaag aactcccgtc ctaccagaag gaacactacc     3180

caaaatacag gttattccag tgggactcaa aatgccaact acccagtgag agctgcccct     3240

cctcccccag gataccatca gaacggagtc atcagaaacc agtatgtgcc atatccccat     3300

gctcctggaa gccagaggtc caatcagaaa agcctgtaca cctccatggc ccgcccgccc     3360

ttgcctcggc agcagtctac cagttcagac cgagtgtcac agacgccaga gagcctggat     3420

ttcctcaagg tcccggacca gggagctgca ggggtcagga gacaaacaac cagtcggcct     3480

cccccagcag ggggcagacc caagccccag cccaagccca agcctcaggt gccacagtgc     3540

aaggctttgt atgcctatga cgctcaggac acagacgaac tcagctttaa tgccaatgac     3600

attattgata ttatcaaaga agatccttct ggctggtgga cgggtcgact acgaggcaag     3660

cagggcctgt tccccaacaa ctatgtgacc aagatctgag gtgcccgtga ctctgacaca     3720

tggggcagag gagctccagg cacagaccag gggaggggat atttaggggc tccccttaca     3780

atccacaatg agcaattgct tctccaaggc ctggagctat tctggtacct tccccatgga     3840

ggacactgaa aaggctgggt tggggacagg gagtatcact ccataagtga tcctaaaagg     3900

tagcctcttc ataggaaccc aggaggacaa aaccaccatg cattaagatt tatttattgt     3960

atttaaacct ggtgagagga caagtgaggt ctgctcagac cttgtaggct tctatcaaaa     4020

cagcaccctg cttgctcacc aggcctagag aatggctgta ggtggccgct gacaagtgcc     4080

tttagttgaa gagcacattt ctttcatctc tcttgtccat acctgataga cacattcctc     4140

tctgccacct tccttcaggg aggacccgcc ctctgcagac tgggcttagc gtgagcaggc     4200

acttcccatg tacgtgccaa gggtaagctg gcctgctgag cccagggcga cagaggggca     4260

ctggtttaca ctttgccggg accatcaggg ccgccaagca ggtcaggggc tgggggctgg     4320

gggctgggct gctggctttg ctttctctgg gtcttcaatt agaatgtggc tggcccatat     4380

tggtttgtgt ttaaatgctg tacttactac aagaaggatc ttttttcaag ctgtacattt     4440

ataaaaacag atcatatact gtatatataa aaatcttgag atggtagaaa catgtatgaa     4500

tgtactaagt agtattccac tgtactcatt cataaggtag gttttcttac aaaactcaca     4560

ccaggtactt aaagatgtgc tctgcttttt tccaactacg gagtgtcact gctttctagg     4620

tcagtccctg cagactcttc tcaactcttt ccctatagga aacttactcc gcgtcctgcc     4680

cccacctcct aaataaataa aggaatcggc gaacaccttc ttcttttatg acatttgtta     4740

tgggttgaat tgtgtgcctc caaagaagat gttggagtcc cagccaccag tacctcacaa     4800

tatgacctta tttggaaata gagtctttat ggagcaaaca aacaaaacta attaaaatga     4860

agtcattaga gtgggtctta atccaatata atggtgtcct gatgaaaagg ggaaatttgg     4920

acacagagac caacatgcca gaggaaagac catgtgaaaa ggcagggaga agacagccat     4980

tcacaagccc tggacagagg cctggaacag attctccctc acaccctcac aaggaaccag     5040

ccctgcccac cttggtcttg gacttccaac ctccagaact gtgaggcaat acatttcgct     5100

gtttaagcca aaaaaaaaaa aaaaa                                           5125


<210>  83
<211>  1108
<212>  PRT
<213>  homo sapiens

<400>  83

Met Gly Ser Lys Gly Val Tyr Gln Tyr His Trp Gln Ser His Asn Val 
1               5                   10                  15      


Lys His Ser Gly Val Asp Asp Met Val Leu Leu Ser Lys Ile Thr Glu 
            20                  25                  30          


Asn Ser Ile Val Glu Asn Leu Lys Lys Arg Tyr Met Asp Asp Tyr Ile 
        35                  40                  45              


Phe Thr Tyr Ile Gly Ser Val Leu Ile Ser Val Asn Pro Phe Lys Gln 
    50                  55                  60                  


Met Pro Tyr Phe Gly Glu Lys Glu Ile Glu Met Tyr Gln Gly Ala Ala 
65                  70                  75                  80  


Gln Tyr Glu Asn Pro Pro His Ile Tyr Ala Leu Ala Asp Asn Met Tyr 
                85                  90                  95      


Arg Asn Met Ile Ile Asp Arg Glu Asn Gln Cys Val Ile Ile Ser Gly 
            100                 105                 110         


Glu Ser Gly Ala Gly Lys Thr Val Ala Ala Lys Tyr Ile Met Ser Tyr 
        115                 120                 125             


Ile Ser Arg Val Ser Gly Gly Gly Thr Lys Val Gln His Val Lys Asp 
    130                 135                 140                 


Ile Ile Leu Gln Ser Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys 
145                 150                 155                 160 


Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Tyr Phe Glu Ile 
                165                 170                 175     


Gln Phe Ser Pro Gly Gly Glu Pro Asp Gly Gly Lys Ile Ser Asn Phe 
            180                 185                 190         


Leu Leu Glu Lys Ser Arg Val Val Met Arg Asn Pro Gly Glu Arg Ser 
        195                 200                 205             


Phe His Ile Phe Tyr Gln Leu Ile Glu Gly Ala Ser Ala Glu Gln Lys 
    210                 215                 220                 


His Ser Leu Gly Ile Thr Ser Met Asp Tyr Tyr Tyr Tyr Leu Ser Leu 
225                 230                 235                 240 


Ser Gly Ser Tyr Lys Val Asp Asp Ile Asp Asp Arg Arg Glu Phe Gln 
                245                 250                 255     


Glu Thr Leu His Ala Met Asn Val Ile Gly Ile Phe Ala Glu Glu Gln 
            260                 265                 270         


Thr Leu Val Leu Gln Ile Val Ala Gly Ile Leu His Leu Gly Asn Ile 
        275                 280                 285             


Ser Phe Lys Glu Val Gly Asn Tyr Ala Ala Val Glu Ser Glu Glu Phe 
    290                 295                 300                 


Leu Ala Phe Pro Ala Tyr Leu Leu Gly Ile Asn Gln Asp Arg Leu Lys 
305                 310                 315                 320 


Glu Lys Leu Thr Ser Arg Gln Met Asp Ser Lys Trp Gly Gly Lys Ser 
                325                 330                 335     


Glu Ser Ile His Val Thr Leu Asn Val Glu Gln Ala Cys Tyr Thr Arg 
            340                 345                 350         


Asp Ala Leu Ala Lys Ala Leu His Ala Arg Val Phe Asp Phe Leu Val 
        355                 360                 365             


Asp Ser Ile Asn Lys Ala Met Glu Lys Asp His Glu Glu Tyr Asn Ile 
    370                 375                 380                 


Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn Gly Phe 
385                 390                 395                 400 


Glu Gln Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln Ile Phe 
                405                 410                 415     


Ile Glu Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln Glu Gly 
            420                 425                 430         


Ile Arg Trp Thr Pro Ile Glu Tyr Phe Asn Asn Lys Ile Val Cys Asp 
        435                 440                 445             


Leu Ile Glu Asn Lys Val Asn Pro Pro Gly Ile Met Ser Ile Leu Asp 
    450                 455                 460                 


Asp Val Cys Ala Thr Met His Ala Val Gly Glu Gly Ala Asp Gln Thr 
465                 470                 475                 480 


Leu Leu Gln Lys Leu Gln Met Gln Ile Gly Ser His Glu His Phe Asn 
                485                 490                 495     


Ser Trp Asn Gln Gly Phe Ile Ile His His Tyr Ala Gly Lys Val Ser 
            500                 505                 510         


Tyr Asp Met Asp Gly Phe Cys Glu Arg Asn Arg Asp Val Leu Phe Met 
        515                 520                 525             


Asp Leu Ile Glu Leu Met Gln Ser Ser Glu Leu Pro Phe Ile Lys Ser 
    530                 535                 540                 


Leu Phe Pro Glu Asn Leu Gln Ala Asp Lys Lys Gly Arg Pro Thr Thr 
545                 550                 555                 560 


Ala Gly Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ser Thr Leu 
                565                 570                 575     


Met Lys Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Glu Thr 
            580                 585                 590         


Lys Lys Pro Arg Asp Trp Glu Glu Ser Arg Val Lys His Gln Val Glu 
        595                 600                 605             


Tyr Leu Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly Tyr Ala 
    610                 615                 620                 


Tyr Arg Arg Ile Phe Gln Lys Phe Leu Gln Arg Tyr Ala Ile Leu Thr 
625                 630                 635                 640 


Lys Ala Thr Trp Pro Ser Trp Gln Gly Glu Glu Lys Gln Gly Val Leu 
                645                 650                 655     


His Leu Leu Gln Ser Val Asn Met Asp Ser Asp Gln Phe Gln Leu Gly 
            660                 665                 670         


Arg Ser Lys Val Phe Ile Lys Ala Pro Glu Ser Leu Phe Leu Leu Glu 
        675                 680                 685             


Glu Met Arg Glu Arg Lys Tyr Asp Gly Tyr Ala Arg Val Ile Gln Lys 
    690                 695                 700                 


Ser Trp Arg Lys Phe Val Ala Arg Lys Lys Tyr Val Gln Met Arg Glu 
705                 710                 715                 720 


Glu Ala Ser Asp Leu Leu Leu Asn Lys Lys Glu Arg Arg Arg Asn Ser 
                725                 730                 735     


Ile Asn Arg Asn Phe Ile Gly Asp Tyr Ile Gly Met Glu Glu His Pro 
            740                 745                 750         


Glu Leu Gln Gln Phe Val Gly Lys Arg Glu Lys Ile Asp Phe Ala Asp 
        755                 760                 765             


Thr Val Thr Lys Tyr Asp Arg Arg Phe Lys Gly Val Lys Arg Asp Leu 
    770                 775                 780                 


Leu Leu Thr Pro Lys Cys Leu Tyr Leu Ile Gly Arg Glu Lys Val Lys 
785                 790                 795                 800 


Gln Gly Pro Asp Lys Gly Leu Val Lys Glu Val Leu Lys Arg Lys Ile 
                805                 810                 815     


Glu Ile Glu Arg Ile Leu Ser Val Ser Leu Ser Thr Met Gln Asp Asp 
            820                 825                 830         


Ile Phe Ile Leu His Glu Gln Glu Tyr Asp Ser Leu Leu Glu Ser Val 
        835                 840                 845             


Phe Lys Thr Glu Phe Leu Ser Leu Leu Ala Lys Arg Tyr Glu Glu Lys 
    850                 855                 860                 


Thr Gln Lys Gln Leu Pro Leu Lys Phe Ser Asn Thr Leu Glu Leu Lys 
865                 870                 875                 880 


Leu Lys Lys Glu Asn Trp Gly Pro Trp Ser Ala Gly Gly Ser Arg Gln 
                885                 890                 895     


Val Gln Phe His Gln Gly Phe Gly Asp Leu Ala Val Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Val Leu Gln Val Ser Ile Gly Pro Gly Leu Pro Lys Asn Ser 
        915                 920                 925             


Arg Pro Thr Arg Arg Asn Thr Thr Gln Asn Thr Gly Tyr Ser Ser Gly 
    930                 935                 940                 


Thr Gln Asn Ala Asn Tyr Pro Val Arg Ala Ala Pro Pro Pro Pro Gly 
945                 950                 955                 960 


Tyr His Gln Asn Gly Val Ile Arg Asn Gln Tyr Val Pro Tyr Pro His 
                965                 970                 975     


Ala Pro Gly Ser Gln Arg Ser Asn Gln Lys Ser Leu Tyr Thr Ser Met 
            980                 985                 990         


Ala Arg Pro Pro Leu Pro Arg Gln  Gln Ser Thr Ser Ser  Asp Arg Val 
        995                 1000                 1005             


Ser Gln  Thr Pro Glu Ser Leu  Asp Phe Leu Lys Val  Pro Asp Gln 
    1010                 1015                 1020             


Gly Ala  Ala Gly Val Arg Arg  Gln Thr Thr Ser Arg  Pro Pro Pro 
    1025                 1030                 1035             


Ala Gly  Gly Arg Pro Lys Pro  Gln Pro Lys Pro Lys  Pro Gln Val 
    1040                 1045                 1050             


Pro Gln  Cys Lys Ala Leu Tyr  Ala Tyr Asp Ala Gln  Asp Thr Asp 
    1055                 1060                 1065             


Glu Leu  Ser Phe Asn Ala Asn  Asp Ile Ile Asp Ile  Ile Lys Glu 
    1070                 1075                 1080             


Asp Pro  Ser Gly Trp Trp Thr  Gly Arg Leu Arg Gly  Lys Gln Gly 
    1085                 1090                 1095             


Leu Phe  Pro Asn Asn Tyr Val  Thr Lys Ile 
    1100                 1105             


<210>  84
<211>  6152
<212>  DNA
<213>  homo sapiens

<400>  84
cgcgctgccc cctttacccc gggccgcgcc ccggggcccc gcactgacgg cccatggcgc       60

cgccagccgc ccgcctcgcc ctgctctccg ccgcggcgct cacgctggcg gcccggcccg      120

cgcctagccc cggcctcggc cccggacccg agtgtttcac agccaatggt gcggattata      180

ggggaacaca gaactggaca gcactacaag gcgggaagcc atgtctgttt tggaacgaga      240

ctttccagca tccatacaac actctgaaat accccaacgg ggaggggggc ctgggtgagc      300

acaactattg cagaaatcca gatggagacg tgagcccctg gtgctatgtg gcagagcacg      360

aggatggtgt ctactggaag tactgtgaga tacctgcttg ccagatgcct ggaaaccttg      420

gctgctacaa ggatcatgga aacccacctc ctctaactgg caccagtaaa acgtccaaca      480

aactcaccat acaaacttgc atcagttttt gtcggagtca gaggttcaag tttgctggga      540

tggagtcagg ctatgcttgc ttctgtggaa acaatcctga ttactggaag tacggggagg      600

cagccagtac cgaatgcaac agcgtctgct tcggggatca cacccaaccc tgtggtggcg      660

atggcaggat catcctcttt gatactctcg tgggcgcctg cggtgggaac tactcagcca      720

tgtcttctgt ggtctattcc cctgacttcc ccgacaccta tgccacgggg agggtctgct      780

actggaccat ccgggttccg ggggcctccc acatccactt cagcttcccc ctatttgaca      840

tcagggactc ggcggacatg gtggagcttc tggatggcta cacccaccgt gtcctagccc      900

gcttccacgg gaggagccgc ccacctctgt ccttcaacgt ctctctggac ttcgtcatct      960

tgtatttctt ctctgatcgc atcaatcagg cccagggatt tgctgtttta taccaagccg     1020

tcaaggaaga actgccacag gagaggcccg ctgtcaacca gacggtggcc gaggtgatca     1080

cggagcaggc caacctcagt gtcagcgctg cccggtcctc caaagtcctc tatgtcatca     1140

ccaccagccc cagccaccca cctcagactg tcccaggatg gacagtctat ggtctggcaa     1200

ctctcctcat cctcacagtc acagccattg tagcaaagat acttctgcac gtcacattca     1260

aatcccatcg tgttcctgct tcaggggacc ttagggattg tcatcaacca gggacttcgg     1320

gggaaatctg gagcattttt tacaagcctt ccacttcaat ttccatcttt aagaagaaac     1380

tcaagggtca gagtcaacaa gatgaccgca atccccttgt gagtgactaa aaaccccact     1440

gtgcctagga cttgaggtcc ctctttgagc tcaaggctgc cgtggtcaac ctctcctgtg     1500

gttcttctct gacagactct tcccctcctc tccctctgcc tcggcctctt cggggaaacc     1560

ctcctcctac agactaggaa gaggcaccct gctgccaggg caggcagagc ctggattcct     1620

cctgcttcat cgattgcact taggagagag actcaaagcc ctggggcccg gccctctctg     1680

catctctctc tgatctagct agcagtgggg gtgtcaggac agtgaggctg agatgacaga     1740

ggtggtcatg gctggcacag ggctcaggta cattctagat ggctgtcagg tggtgggtag     1800

ctttagttac attgaatttt tcttgcttct ctatttttgt ccacacacaa atcagtttct     1860

cctgatcttt atgtcttgga acagggccag acagggagaa ctctcaggta ctcttgggag     1920

ttggtcccat acaagtgcgg actcctggac attagcgagg tgtaaagagg gcagtgtctg     1980

tgctgccccg gcagctttgc tctccagatg ctggactagg gtgggcctcc ttcagcctgg     2040

gagggtctga gaataagatc tagtgacccc catttatatc aaacctgata ccttacacat     2100

gggcttcttt ctagattctt ctttccatag ctcatggagc tgcagggaaa gctttaagag     2160

ctttggtcat ataaaacatc cattcagctg ggcgcgatgg ctcatgcctg taatcccagc     2220

actgtgggag gctgaggcgg gcagatcacc tgaggtcagg agttcgagac cagcctggcc     2280

aacatggtga aaccccgtct ctactaaaaa tataaaaatt agtcaggcgt ggtggcaggc     2340

gcctgtaatc ccagctactc agaaggctga gacagaagaa cagcttgaac ccaggaggct     2400

gagattgcag tgagccgaga tcgcaccact gcactccagc ctgggtgaca agagtgagac     2460

tctgtctcaa aaaaacaaaa cacaaataaa caaaaaaaat ccattcattt actcatgcaa     2520

taaattctcc tgcaagcttt tatgggcact cagtaagtac tcaggattgg ctttatcagc     2580

cttgccactg agcagctcat ggtcctatgg aacctgagcc aggcctcagt ctctccatga     2640

ttggctcagc taactctcag ttcagagtgg agagtatcaa tcttgtgttt ttgcccttag     2700

gcagcactat atgagacatg gggcctgtgg tccttccttc tggtgtcccc cgtgttaaaa     2760

gataaaaaac accccaaggg ccgggcgcgg tggctcatgc ctgtaatccc agcactttgg     2820

gaggctgagg cgggtggatc acgaggtcag gtgatcgaaa ccatcctggc taagatggtg     2880

aaaccccgtc tctactaaaa atacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag     2940

tcccagctgc tcgggaggct gaggcaggag aatggcgtga acccgggagg cggagcttgc     3000

agtgagcaga gatcacgcca ctgcactcca gcctgggtga cagtgcaaga ctctgtctca     3060

aaaaaaaaaa aaacactcca agggccatcc gtgctctctg cccctcctgt ggggaccaag     3120

tggggttagg aatggctcag tggggaagga gagcactctt gtccccagtc ccttgccacc     3180

ctgtccctta gatagggagg tgggctgcag agattggtgc cagaagaggg tgggtttggg     3240

aattggagct cctccaagga gctcctccta agattgagtg ctgcagctgt agtggctgct     3300

ggttgggaga gtaagtgcca tcactaattt aaaagtcctt gccatctgga atcaggcttt     3360

gtcaacagca gctgagaaaa gcagcctgtg cctctgctgg ccaggcctag gccctcgtca     3420

gagcgtgcct ctccacaagg cacttgggcc tgggtgattg ttgcgcctct ggctttggcg     3480

tttcctcttt gcagcacttt gcctacctcc cccaagccct gagccactgc ctgctggggc     3540

tcctactgag gttctggaaa cacctctgca cctgccgccc ctgggaggaa agagggccac     3600

acaggaagtg tctgcaggga gaggtggcac tcggcagcct gagttcagga gaggtgcttg     3660

gagcttcagg cagaggggcc ttcagaggag ggaaacggag caatgtgtca caggcaggca     3720

ggggcaggac tgccacccca ggccccgtgg gaggcctgct gagggcacag agctgctcgg     3780

tgcagccttc atgctttgat ctggaaagag cagctgtccg caggcctctg tctccaagag     3840

gcctgtcaca caggaggacc gctggaaaca taccaacacg tgcagtctcc cctccaagct     3900

attcatgctg tttgtggaat ctctctcaaa cataagtgtc aggtgtgtgt cgtcccaacg     3960

ggtcctgtgc tgtgaataga tccatgtgca gcacaaaggg aatgtggcac gtggccccag     4020

gaagagttca cccggccagg gggcagttgt tcagttgcct ggggctgaca ctgaccactg     4080

gcctctgggg tgtcctgcag cccaaatgcc caccttgccc tcctcacatc tcagtcaggg     4140

gaggccatgc ccaagccaat gtgctgtcac agcctgcagc gggggcagca cttcctcgga     4200

gggcctggga ggtgctgggg atgccccagc gcttctcttc ctgcctcgcc ctggcatggc     4260

ccagcgcctc taggatcaac ttacgatccg tggagcagcc ccgggaaacc caaatctggc     4320

tcaggacagc gtacgggcag gagggctgta aatcatccca ggctaagcct ccgtgggcac     4380

tggctcctgc cgcagcctgg ctatggactc agttagaacc aggtagaaag tcagcgacac     4440

cccacagaag gccactgcgg ctaggtaaac acctgagaaa gaaactgctc cagaagagat     4500

gacgtgggct tccaggagca tggaggaggt ggcacttgaa cttttaggaa actccttaga     4560

tgagataaag tgggggttgg aggtggcgaa aagagggtaa ccctgggaaa gtcagtcaga     4620

acccatggca gaagactgca ggagaggcag gggaggggct tcggggacca ctgtggacag     4680

agctctgaaa gcaccctggc caaagcccct cctgaggtga cagagcgtgg gaggaggctg     4740

cactgggcct gcgtgccatc ctcacccctg ttccccgctg gcgccaggcc ctgccttctt     4800

ggtacctgtg ccaacaggag agccctcacc agccgatctt gtcactctcc gtggtgacag     4860

tgtcttggcc agctgtggcc cctagtttct agcagcgttt ctcagtgtcc ttggcccttc     4920

tgagaaggca ggcgggaggc acacggtgcc ctgttcttcc ccgtttgtcc agttgcttgc     4980

aaagcagaga atgagtagga gtgaacccga gtgacttcac ccgccctgtc ccccacgtca     5040

ggacaggctt gaggcctctc tgggcgtgag cgaggaaacc aggctgctct aacttctgaa     5100

gagtgggctc tggctcaaga ctccaatcgg ccagaagccc acagagatca aagcactagc     5160

aagttcagct gtcctggccc tcgggtagaa cccacgggcg tgcctgggtg cggctccacc     5220

cacatgcccc actgtcagcc caggcaggag ccttcctggc cgggctcagg atctgcctgc     5280

agcccagcca ggccatcacc cagccccgat gcatcctggc actgcacgct tactcttcac     5340

aagcacttat acgcggatgg cctccgagac cctgcctccc tggtctgctg aggtcaggcc     5400

aggtctccca cggagccggg cagctccaca ccccaccacc tggcaccgtt aggtttcaga     5460

tctcccgtgt ggtgtttgat gtcggctttt gttcctacct tgggagtttg gattgtttcc     5520

tctggtgtct ttgtttacct tcctcactgt tctacctcct ggccaggtct cagcttagct     5580

tccctggtgt ggggtgtttt tcaagccttc cagccacagc tgtctcccct caggctggac     5640

ggctccgggg tgacagggct tcaccctctg cctgcagacc cctggtgggc acatctcaca     5700

ggcttccgtc ttgctgagtt gggtacggag gcagaagtgg ggtgtggagg aaagtcagag     5760

ggaaatctgc ttcagaaagg aagggtcttt agacacaaag actggaggcc cttccccgcc     5820

cgcacgggag ctgccatcgt gggtctcatg cacgtcaaga ccttcccaca tccaaactca     5880

gcttccagca gggattttga ctttggatga caaggcttta tttgtaaata tgctcttaat     5940

atgcaacttt gagaataaaa tagaaacatc atgtatttta aaatataaga tgaagtgtga     6000

cgcactgtat acaatttaat atatattttt agggttttgt tatttaagaa aatggaatgt     6060

aatggtactt ttacaaaaga gaaaaaatgt tatttttact ttctggaaaa aataaatatt     6120

ctcattgttg tagaaagaaa aaaaaaaaaa aa                                   6152


<210>  85
<211>  458
<212>  PRT
<213>  homo sapiens

<400>  85

Met Ala Pro Pro Ala Ala Arg Leu Ala Leu Leu Ser Ala Ala Ala Leu 
1               5                   10                  15      


Thr Leu Ala Ala Arg Pro Ala Pro Ser Pro Gly Leu Gly Pro Gly Pro 
            20                  25                  30          


Glu Cys Phe Thr Ala Asn Gly Ala Asp Tyr Arg Gly Thr Gln Asn Trp 
        35                  40                  45              


Thr Ala Leu Gln Gly Gly Lys Pro Cys Leu Phe Trp Asn Glu Thr Phe 
    50                  55                  60                  


Gln His Pro Tyr Asn Thr Leu Lys Tyr Pro Asn Gly Glu Gly Gly Leu 
65                  70                  75                  80  


Gly Glu His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Ser Pro Trp 
                85                  90                  95      


Cys Tyr Val Ala Glu His Glu Asp Gly Val Tyr Trp Lys Tyr Cys Glu 
            100                 105                 110         


Ile Pro Ala Cys Gln Met Pro Gly Asn Leu Gly Cys Tyr Lys Asp His 
        115                 120                 125             


Gly Asn Pro Pro Pro Leu Thr Gly Thr Ser Lys Thr Ser Asn Lys Leu 
    130                 135                 140                 


Thr Ile Gln Thr Cys Ile Ser Phe Cys Arg Ser Gln Arg Phe Lys Phe 
145                 150                 155                 160 


Ala Gly Met Glu Ser Gly Tyr Ala Cys Phe Cys Gly Asn Asn Pro Asp 
                165                 170                 175     


Tyr Trp Lys Tyr Gly Glu Ala Ala Ser Thr Glu Cys Asn Ser Val Cys 
            180                 185                 190         


Phe Gly Asp His Thr Gln Pro Cys Gly Gly Asp Gly Arg Ile Ile Leu 
        195                 200                 205             


Phe Asp Thr Leu Val Gly Ala Cys Gly Gly Asn Tyr Ser Ala Met Ser 
    210                 215                 220                 


Ser Val Val Tyr Ser Pro Asp Phe Pro Asp Thr Tyr Ala Thr Gly Arg 
225                 230                 235                 240 


Val Cys Tyr Trp Thr Ile Arg Val Pro Gly Ala Ser His Ile His Phe 
                245                 250                 255     


Ser Phe Pro Leu Phe Asp Ile Arg Asp Ser Ala Asp Met Val Glu Leu 
            260                 265                 270         


Leu Asp Gly Tyr Thr His Arg Val Leu Ala Arg Phe His Gly Arg Ser 
        275                 280                 285             


Arg Pro Pro Leu Ser Phe Asn Val Ser Leu Asp Phe Val Ile Leu Tyr 
    290                 295                 300                 


Phe Phe Ser Asp Arg Ile Asn Gln Ala Gln Gly Phe Ala Val Leu Tyr 
305                 310                 315                 320 


Gln Ala Val Lys Glu Glu Leu Pro Gln Glu Arg Pro Ala Val Asn Gln 
                325                 330                 335     


Thr Val Ala Glu Val Ile Thr Glu Gln Ala Asn Leu Ser Val Ser Ala 
            340                 345                 350         


Ala Arg Ser Ser Lys Val Leu Tyr Val Ile Thr Thr Ser Pro Ser His 
        355                 360                 365             


Pro Pro Gln Thr Val Pro Gly Trp Thr Val Tyr Gly Leu Ala Thr Leu 
    370                 375                 380                 


Leu Ile Leu Thr Val Thr Ala Ile Val Ala Lys Ile Leu Leu His Val 
385                 390                 395                 400 


Thr Phe Lys Ser His Arg Val Pro Ala Ser Gly Asp Leu Arg Asp Cys 
                405                 410                 415     


His Gln Pro Gly Thr Ser Gly Glu Ile Trp Ser Ile Phe Tyr Lys Pro 
            420                 425                 430         


Ser Thr Ser Ile Ser Ile Phe Lys Lys Lys Leu Lys Gly Gln Ser Gln 
        435                 440                 445             


Gln Asp Asp Arg Asn Pro Leu Val Ser Asp 
    450                 455             


<210>  86
<211>  3646
<212>  DNA
<213>  homo sapiens

<400>  86
ctctccggcc gccgccggtg cgggtgctcc gctaccggct cctctccgtt ctgtgctctc       60

ttctgctctc ggctccccac cccctctccc ttccctcctc tccccttgcc tcccctcctc      120

tgcagcgcct gcattatttt ctgcccgcag gctcggcttg cactgctgct gcagcccggg      180

gaggtggctg ggtgggtggg gaggagactg tgcaagttgt aggggagggg gtgccctctt      240

cttccccgct cccttccccc gccaactcct tcccctcctt ctcccccttt cccctccccg      300

cccccacctt cttcctcctt tcggaaggac tggtaacttg tcgtgcggag cgaacggcgg      360

cggcggcggc ggcggcggca ccatccaggc gggcaccatg ggcacgtccg cgctctgggc      420

gctctggctg ctgctcgcgc tgtgctgggc gccccgggag agcggcgcca ccggaaccgg      480

gagaaaagcc aaatgtgaac cctcccaatt ccagtgcaca aatggtcgct gtattacgct      540

gttgtggaaa tgtgatgggg atgaagactg tgttgacggc agtgatgaaa agaactgtgt      600

aaagaagacg tgtgctgaat ctgacttcgt gtgcaacaat ggccagtgtg ttcccagccg      660

atggaagtgt gatggagatc ctgactgcga agatggttca gatgaaagcc cagaacagtg      720

ccatatgaga acatgccgca tacatgaaat cagctgtggc gcccattcta ctcagtgtat      780

cccagtgtcc tggagatgtg atggtgaaaa tgattgtgac agtggagaag atgaagaaaa      840

ctgtggcaat ataacatgta gtcccgacga gttcacctgc tccagtggcc gctgcatctc      900

caggaacttt gtatgcaatg gccaggatga ctgcagcgat ggcagtgatg agctggactg      960

tgccccgcca acctgtggcg cccatgagtt ccagtgcagc acctcctcct gcatccccat     1020

cagctgggta tgcgacgatg atgcagactg ctccgaccaa tctgatgagt ccctggagca     1080

gtgtggccgt cagccagtca tacacaccaa gtgtccagcc agcgaaatcc agtgcggctc     1140

tggcgagtgc atccataaga agtggcgatg tgatggggac cctgactgca aggatggcag     1200

tgatgaggtc aactgtccct ctcgaacttg ccgacctgac caatttgaat gtgaggatgg     1260

cagctgcatc catggcagca ggcagtgtaa tggtatccga gactgtgtcg atggttccga     1320

tgaagtcaac tgcaaaaatg tcaatcagtg cttgggccct ggaaaattca agtgcagaag     1380

tggagaatgc atagatatca gcaaagtatg taaccaggag caggactgca gggactggag     1440

tgatgagccc ctgaaagagt gtcatataaa cgaatgcttg gtaaataatg gtggatgttc     1500

tcatatctgc aaagacctag ttataggcta cgagtgtgac tgtgcagctg ggtttgaact     1560

gatagatagg aaaacctgtg gagatattga tgaatgccaa aatccaggaa tctgcagtca     1620

aatttgtatc aacttaaaag gcggttacaa gtgtgaatgt agtcgtggct atcaaatgga     1680

tcttgctact ggcgtgtgca aggcagtagg caaagagcca agtctgatct tcactaatcg     1740

aagagacatc aggaagattg gcttagagag gaaagaatat atccaactag ttgaacagct     1800

aagaaacact gtggctctcg atgctgacat tgctgcccag aaactattct gggccgatct     1860

aagccaaaag gctatcttca gtgcctcaat tgatgacaag gttggtagac atgttaaaat     1920

gatcgacaat gtctataatc ctgcagccat tgctgttgat tgggtgtaca agaccatcta     1980

ctggactgat gcggcttcta agactatttc agtagctacc ctagatggaa ccaagaggaa     2040

gttcctgttt aactctgact tgcgagagcc tgcctccata gctgtggacc cactgtctgg     2100

ctttgtttac tggtcagact ggggtgaacc agctaaaata gaaaaagcag gaatgaatgg     2160

attcgataga cgtccactgg tgacagcgga tatccagtgg cctaacggaa ttacacttga     2220

ccttataaaa agtcgcctct attggcttga ttctaagttg cacatgttat ccagcgtgga     2280

cttgaatggc caagatcgta ggatagtact aaagtctctg gagttcctag ctcatcctct     2340

tgcactaaca atatttgagg atcgtgtcta ctggatagat ggggaaaatg aagcagtcta     2400

tggtgccaat aaattcactg gatcagagct agccactcta gtcaacaacc tgaatgatgc     2460

ccaagacatc attgtctatc atgaacttgt acagccatca ggtaaaaatt ggtgtgaaga     2520

agacatggag aatggaggat gtgaatacct atgcctgcca gcaccacaga ttaatgatca     2580

ctctccaaaa tatacctgtt cctgtcccag tgggtacaat gtagaggaaa atggccgaga     2640

ctgtcaaagt actgcaacta ctgtgactta cagtgagaca aaagatacga acacaacaga     2700

aatttcagca actagtggac tagttcctgg agggatcaat gtgaccacag cagtatcaga     2760

ggtcagtgtt cccccaaaag ggacttctgc cgcatgggcc attcttcctc tcttgctctt     2820

agtgatggca gcagtaggtg gctacttgat gtggcggaat tggcaacaca agaacatgaa     2880

aagcatgaac tttgacaatc ctgtgtactt gaaaaccact gaagaggacc tctccataga     2940

cattggtaga cacagtgctt ctgttggaca cacgtaccca gcaatatcag ttgtaagcac     3000

agatgatgat ctagcttgac ttctgtgaca aatgttgacc tttgaggtct aaacaaataa     3060

tacccccgtc ggaatggtaa ccgagccagc agctgaagtc tctttttctt cctctcggct     3120

ggaagaacat caagatacct ttgcgtggat caagcttgtg tacttgaccg tttttatatt     3180

acttttgtaa atattcttgt ccacattcta cttcagcttt ggatgtggtt accgagtatc     3240

tgtaaccctt gaatttctag acagtattgc cacctctggc caaatatgca ctttccctag     3300

aaagccatat tccagcagtg aaacttgtgc tatagtgtat accacctgta catacattgt     3360

ataggccatc tgtaaatatc ccagagaaca atcactattc ttaagcactt tgaaaatatt     3420

tctatgtaaa ttattgtaaa ctttttcaat ggttgggaca atggcaatag gacaaaacgg     3480

gttactaaga tgaaattgcc aaaaaaattt ataaactaat tttgtacgta tgaatgatat     3540

ctttgacctc aatggaggtt tgcaaagact gagtgttcaa actactgtac attttttttc     3600

aagtgctaaa aaattaaacc aagcagctta accatgaaaa aaaaaa                    3646


<210>  87
<211>  873
<212>  PRT
<213>  homo sapiens

<400>  87

Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Ser Thr 
            740                 745                 750         


Ala Thr Thr Val Thr Tyr Ser Glu Thr Lys Asp Thr Asn Thr Thr Glu 
        755                 760                 765             


Ile Ser Ala Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210>  88
<211>  7218
<212>  DNA
<213>  homo sapiens

<400>  88
gccccgcatc gtgcccggcc ccgtcgcgga gatcccggac gaccgtcgcg ggttgatggt       60

cgcattccag atgtaaacag cttcagaagc ctgacggtca tatggtagaa tcactgtgga      120

ctgagaccca cctttctaga cctgaagccc aggaggagga agaggaggct ggttggtacc      180

atgggcataa tgctctgaat cctagtctct cacctagtat gtgagcagtc cctgcagatg      240

gcccatttgg agatcttgac aaagcctctt ctgtttccaa tggggttttt ggcgcattct      300

cacagactta gatgaaactg tgatggccac cgcagggggc aggtgctgac atcgtcccca      360

gccctgtggc tgttcatccg gacatcattt ccaacctcaa tatctaaatg ccacagtgct      420

cttggagcaa gttgggctgg ggaccactgt tgccttttaa gaccataaaa ccatgggaaa      480

cgcagaaagt caacatgtag agcacgagtt ttatggagaa aagcatgcca gcctggggcg      540

caagcacact tcccgctccc tgcgcctctc gcacaagacg cggaggacca ggcacgcttc      600

ctcggggaag gtgatccaca ggaactccga agtgagcacc cgatccagca gcacccccag      660

catcccccag tccctggctg aaaatggcct ggagcccttc tcccaagatg gtaccctaga      720

agacttcggg agccccatct gggtggaccg agtggacatg ggcttgagac ctgtgtctta      780

cactgactct tctgtcactc ccagcgtaga cagcagcatc gtcctcacag cagcctctgt      840

gcagagcatg ccagacactg aggagagcag gctttacggg gatgacgcta catatttggc      900

tgagggaggc aggaggcagc attcctatac atccaatggg cccactttca tggagacggc      960

gagctttaag aagaaacgct ccaaatctgc agacatctgg cgggaggaca gcctggaatt     1020

ctcactctct gatctgagcc aagaacattt aacaagcaac gaagaaatct tgggttccgc     1080

cgaagagaag gactgcgagg aggctcgggg gatggaaacg cgggcgagtc cgcggcagct     1140

cagcacctgt cagagagcca attccttggg tgacttgtat gctcagaaaa actctggagt     1200

gacagcaaac ggggggccgg ggagcaaatt tgcaggctac tgtcggaatt tggtgtctga     1260

tattcccaat cttgcaaacc ataagatgcc accagctgct gctgaagaga ctcctccgta     1320

cagtaattat aacacacttc cctgtaggaa atctcactgt ctctctgaag gtgccaccaa     1380

cccacaaatt agccatagca acagcatgca aggcagaaga gctaaaacaa ctcaggatgt     1440

taatgcaggc gagggcagtg agtttgcaga cagtgggatt gaaggggcca ctaccgacac     1500

ggacctcctg tccaggcgat ctaatgccac caactccagc tactcaccca ccacaggccg     1560

ggcctttgtg ggcagcgaca gcggcagcag ctccaccggg gatgcggctc gtcagggggt     1620

gtacgagaac ttccggcggg agctggagat gagcaccacc aacagcgaga gcctggagga     1680

ggccggctcg gcgcacagcg atgagcagag cagcggcacc ctgagctctc cgggccagtc     1740

ggacatcctg ctgaccgccg cacagggcac ggtgcgcaag gccggcgccc tggccgtcaa     1800

gaacttcctg gtgcacaaga agaacaagaa ggtggagtca gccacccgga ggaagtggaa     1860

gcactactgg gtgtccctga aaggatgcac gctatttttc tacgagagcg acggcaggtc     1920

tgggatagac cacaacagca tccccaaaca cgccgtctgg gtggagaaca gcattgtgca     1980

ggcggtgcct gagcacccca agaaggactt tgtcttctgc ctcagcaatt ccctgggtga     2040

tgccttcctt tttcagacca ctagccagac ggagcttgaa aactggatca ccgccatcca     2100

ctctgcctgc gccactgcgg tcgcgaggca ccaccacaag gaagacacgc tccgactcct     2160

gaaatcagag atcaaaaaac tggaacagaa gattgacatg gatgaaaaga tgaagaaaat     2220

gggtgaaatg cagctgtctt cagtcactga ctcaaagaaa aagaaaacaa tattagatca     2280

gatctttgtc tgggagcaaa atctcgagca gttccaaatg gacctgtttc gtttccgctg     2340

ttatttagcc agccttcagg gtggggagct gccaaacccc aaaaggcttc tcgcttttgc     2400

aagtcgacca acgaaagtgg ccatgggccg ccttggaatc ttttcggtat catcgtttca     2460

tgccctggtg gcagcacgca ctggtgaaac tggagtgaga agacgtactc aggccatgtc     2520

cagatccgcg agcaagcgaa ggagcaggtt ttcttctctg tggggtctgg atactacctc     2580

caaaaagaag cagggacggc caagcatcaa tcaggtgttt ggagagggaa ccgaagctgt     2640

aaagaaatct ttagagggaa tatttgatga cattgttcca gatggcaaga gggagaaaga     2700

agtggtctta cctaacgttc accagcacaa ccctgactgc gacatttggg tccacgagta     2760

tttcactcca tcctggttct gtctgcccaa taatcagcct gccctgacgg tcgtccggcc     2820

aggcgacact gcacgggaca ccctggagct gatttgcaag acacatcaac tggatcattc     2880

tgctcattac ctgcgcctga aatttctaat agaaaacaaa atgcagctct atgttccaca     2940

gcccgaggaa gacatctatg agctgctgta caaagaaatt gaaatctgtc caaaagtcac     3000

tcagagcatc cacattgaga agtcagatac agctgctgat acttacgggt tttcactttc     3060

ttctgtggaa gaagatggta ttcgaaggct gtacgtgaat agtgtgaagg aaaccggttt     3120

agcttccaag aaaggcctga aagcaggaga tgagattctt gagatcaata atcgtgctgc     3180

tgacgccctg aactcttcta tgctcaaaga tttcctctca cagccctcgc tgggcctcct     3240

ggtgaggacc taccccgagc tggaggaagg agtggagctg ctggaaagcc cgccccaccg     3300

agtggacggc cctgccgacc ttggcgagag ccccctcgcc tttctcacca gcaacccagg     3360

gcacagcctt tgcagcgagc agggcagcag tgctgagacc gctccagagg agaccgaggg     3420

gccagacttg gaatcctcag atgagactga tcacagcagc aagagtacag aacaggtggc     3480

cgcattttgc cgcagtttgc atgagatgaa cccctctgac cagagcccat ctcctcagga     3540

ctccacgggg cctcagctgg cgaccatgag acaactctcg gatgcagata agctgcgcaa     3600

ggtgatctgc gagctcctgg agacggagcg cacctacgtg aaggatttaa actgtcttat     3660

ggagagatac ctaaagcctc ttcaaaaaga aacttttctc acccaggatg agcttgacgt     3720

gctttttgga aatttaacgg aaatggtaga gtttcaagta gaattcctta aaactctaga     3780

agatggagtg agactggtac ctgatttgga aaagcttgag aaggttgatc aatttaagaa     3840

agtgctgttc tctctggggg gatcattcct gtattatgct gaccgcttca agctctacag     3900

tgccttctgc gccagccaca caaaagttcc caaggtcctg gtgaaagcca agacagacac     3960

ggctttcaag gcattcttgg atgcccagaa cccgaagcag cagcactcat ccacgctgga     4020

gtcgtacctc atcaagccca tccagaggat cctcaagtac ccacttctgc tcagggagct     4080

gttcgccctg accgatgcgg agagcgagga gcactaccac ctggacgtgg ccatcaagac     4140

catgaacaag gttgccagtc acatcaatga gatgcagaaa atccatgaag agtttggggc     4200

tgtgtttgac cagctgattg ctgaacagac tggtgagaaa aaagaggttg cagatctgag     4260

catgggagac ctgcttttgc acactaccgt gatctggctg aacccgccgg cctcgctggg     4320

caagtggaaa aaggaaccag agttggcagc attcgtcttc aaaactgctg tggtccttgt     4380

gtataaagat ggttccaaac agaagaagaa acttgtagga tctcacaggc tttccattta     4440

tgaggactgg gaccccttca gatttcgaca catgatcccc acggaagcgc tgcaggttcg     4500

agctttggcg agtgcagatg cagaggcaaa tgccgtgtgt gaaattgtcc atgtaaaatc     4560

cgagtctgaa gggaggccgg agagggtctt tcacttgtgc tgcagctccc cagagagccg     4620

aaaggatttc ctaaaggctg tgcattcaat cctgcgtgat aagcacagaa gacagctcct     4680

caaaaccgag agccttccct catcccagca atatgtccct tttggaggca aaagattgtg     4740

tgcactgaag ggggccaggc cggccatgag cagggcagtg tctgccccaa gcaagtctct     4800

tgggaggagg aggcggcggc tggctcgaaa caggtttacc attgattctg atgccgtctc     4860

cgcaagcagc ccggagaaag agtcccagca gccccccggt ggtggggaca ctgaccgatg     4920

ggtagaggag cagtttgatc ttgctcagta tgaggagcaa gatgacatca aggagacaga     4980

catcctcagt gacgatgatg agttctgtga gtccgtgaag ggtgcctcag tggacagaga     5040

cctgcaggag cggcttcagg ccacctccat cagtcagcgg gaaagaggcc ggaaaaccct     5100

ggatagtcac gcgtcccgca tggcacagct caagaagcaa gctgccctgt cggggatcaa     5160

tggaggcctg gagagcgcaa gcgaggaagt catttgggtt aggcgtgaag actttgcccc     5220

ctccaggaaa ctgaacactg agatctgact gcgtcacctg ccccgtagag aatgtgtgta     5280

gatacttcct gccctaactc tgcccaccct cctgtaccgt cgacaagaat gtccccttag     5340

gtcgcgctct tgcacacacg gttttggcag ctgacttggt tctgaagcca tgtagccacc     5400

caactttgtc attttcaaca acatcagaaa gaattgatca gaatcccaaa taagcttgag     5460

tcctatcttc tgtatattac taagggcttt tatttattct caataaatca gggcctgaac     5520

aattaaaaga aaaaagattc tatagcactg gaaagcaaat caccccagga gttaacggat     5580

gtacaacaga ttaatttaag ggatagtagc acacacacga tccttctatc tgaaatcagt     5640

ctcctagctg gggaaacctc tttcacacac aaaatgaaat gtgtacagct tgccgtgttc     5700

tgactgtacc cttccctctt ccatgtctga gaatctccgt gtattttaag aatgtgtgag     5760

gagagggtgg cgattcatgt ttcaatgagc ctcttttttt ttttccttcc tgttttggtc     5820

tatggctggt cttactctgt gtccatgttc ggaagctcta gttttgcata gaattataga     5880

gatgccaaac tctttgaaaa gagatccaaa tttatcgctt gagagaaaga aaagaaacac     5940

tattttttgt attttacctg agatacaggg gcacaaatag atgagaattt tacagtgtta     6000

gtgtatgtat ccctgagcct aaaaaatgag gatataacct tttacagaga gagtgaggcg     6060

tggtggtttt atatttatat atgaaaggcc agcaagctca tgcgaaggat atacttttct     6120

tccaaaaagc ggattttttt tttttaatgt ttgaatctat atttgagatg ggagtttggt     6180

tggattaaac atgacacccc ggtgggcggt gtgtgtgtct gttgcacatg gcagggaggg     6240

gagcctcctt ctcatggggt tgccatggtg atcattggtt tttccatcaa aattgcatct     6300

tcatccatag attaccttcc ccttccctga cagtccataa ccaaaccttt aaacagaaca     6360

acctctttaa aaacttctct tgtgtttaac actttcttca tgccaacgaa acagggtaaa     6420

catgctcaaa acattaacag tctaaacaga tatccaaata ctaagaagaa aaacaagtta     6480

tagcactttc aatttttttt ttttttttaa aaaaaggttt atagcttttt cttttcccat     6540

gtcacaatgt ccacttccta agaagggttt aaaatactat gaaaactttc tttttgggga     6600

aaatatctat ttggtgtttg acacatcagt aggtacttta aagacctgaa ttttatagta     6660

gctttaggag ttatatttta taaaaatcag ttatgacttt atatttccag acaatagaga     6720

gttcagtaca tcatgctctt gtgcctctgc ctgcttttcc tgcgttccca ccctgtattc     6780

cccccgcctt tcgggtttcc agggcttcga gcttgatctt ttgaaagttt tattctatta     6840

aatttttgct atatcttctg gttttctgaa aaagctttag aatggtttct ataccctttg     6900

tatcactgca tttttccata tcatctccgg ttcgatcgcg tccagatgga aaacggaagc     6960

agaggcttct aatcgtcgca tttactggct ccagtgcaac acatccatct gaaaacactc     7020

ggaagtctgg tgcttggaga gggtgccatt gtctcttgta cataaggtca tgacgtgtct     7080

atgtcaaaag ttcttatata tttcttttat aagctgaaag aaggtctatt tttatgtttt     7140

taggtctatg aatggaacgt tgtaaatgct tgtcaaacaa taaaaataac gaaaagtgaa     7200

aaaaaaaaaa aaaaaaaa                                                   7218


<210>  89
<211>  1591
<212>  PRT
<213>  homo sapiens

<400>  89

Met Gly Asn Ala Glu Ser Gln His Val Glu His Glu Phe Tyr Gly Glu 
1               5                   10                  15      


Lys His Ala Ser Leu Gly Arg Lys His Thr Ser Arg Ser Leu Arg Leu 
            20                  25                  30          


Ser His Lys Thr Arg Arg Thr Arg His Ala Ser Ser Gly Lys Val Ile 
        35                  40                  45              


His Arg Asn Ser Glu Val Ser Thr Arg Ser Ser Ser Thr Pro Ser Ile 
    50                  55                  60                  


Pro Gln Ser Leu Ala Glu Asn Gly Leu Glu Pro Phe Ser Gln Asp Gly 
65                  70                  75                  80  


Thr Leu Glu Asp Phe Gly Ser Pro Ile Trp Val Asp Arg Val Asp Met 
                85                  90                  95      


Gly Leu Arg Pro Val Ser Tyr Thr Asp Ser Ser Val Thr Pro Ser Val 
            100                 105                 110         


Asp Ser Ser Ile Val Leu Thr Ala Ala Ser Val Gln Ser Met Pro Asp 
        115                 120                 125             


Thr Glu Glu Ser Arg Leu Tyr Gly Asp Asp Ala Thr Tyr Leu Ala Glu 
    130                 135                 140                 


Gly Gly Arg Arg Gln His Ser Tyr Thr Ser Asn Gly Pro Thr Phe Met 
145                 150                 155                 160 


Glu Thr Ala Ser Phe Lys Lys Lys Arg Ser Lys Ser Ala Asp Ile Trp 
                165                 170                 175     


Arg Glu Asp Ser Leu Glu Phe Ser Leu Ser Asp Leu Ser Gln Glu His 
            180                 185                 190         


Leu Thr Ser Asn Glu Glu Ile Leu Gly Ser Ala Glu Glu Lys Asp Cys 
        195                 200                 205             


Glu Glu Ala Arg Gly Met Glu Thr Arg Ala Ser Pro Arg Gln Leu Ser 
    210                 215                 220                 


Thr Cys Gln Arg Ala Asn Ser Leu Gly Asp Leu Tyr Ala Gln Lys Asn 
225                 230                 235                 240 


Ser Gly Val Thr Ala Asn Gly Gly Pro Gly Ser Lys Phe Ala Gly Tyr 
                245                 250                 255     


Cys Arg Asn Leu Val Ser Asp Ile Pro Asn Leu Ala Asn His Lys Met 
            260                 265                 270         


Pro Pro Ala Ala Ala Glu Glu Thr Pro Pro Tyr Ser Asn Tyr Asn Thr 
        275                 280                 285             


Leu Pro Cys Arg Lys Ser His Cys Leu Ser Glu Gly Ala Thr Asn Pro 
    290                 295                 300                 


Gln Ile Ser His Ser Asn Ser Met Gln Gly Arg Arg Ala Lys Thr Thr 
305                 310                 315                 320 


Gln Asp Val Asn Ala Gly Glu Gly Ser Glu Phe Ala Asp Ser Gly Ile 
                325                 330                 335     


Glu Gly Ala Thr Thr Asp Thr Asp Leu Leu Ser Arg Arg Ser Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Tyr Ser Pro Thr Thr Gly Arg Ala Phe Val Gly Ser 
        355                 360                 365             


Asp Ser Gly Ser Ser Ser Thr Gly Asp Ala Ala Arg Gln Gly Val Tyr 
    370                 375                 380                 


Glu Asn Phe Arg Arg Glu Leu Glu Met Ser Thr Thr Asn Ser Glu Ser 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Ser Ala His Ser Asp Glu Gln Ser Ser Gly Thr 
                405                 410                 415     


Leu Ser Ser Pro Gly Gln Ser Asp Ile Leu Leu Thr Ala Ala Gln Gly 
            420                 425                 430         


Thr Val Arg Lys Ala Gly Ala Leu Ala Val Lys Asn Phe Leu Val His 
        435                 440                 445             


Lys Lys Asn Lys Lys Val Glu Ser Ala Thr Arg Arg Lys Trp Lys His 
    450                 455                 460                 


Tyr Trp Val Ser Leu Lys Gly Cys Thr Leu Phe Phe Tyr Glu Ser Asp 
465                 470                 475                 480 


Gly Arg Ser Gly Ile Asp His Asn Ser Ile Pro Lys His Ala Val Trp 
                485                 490                 495     


Val Glu Asn Ser Ile Val Gln Ala Val Pro Glu His Pro Lys Lys Asp 
            500                 505                 510         


Phe Val Phe Cys Leu Ser Asn Ser Leu Gly Asp Ala Phe Leu Phe Gln 
        515                 520                 525             


Thr Thr Ser Gln Thr Glu Leu Glu Asn Trp Ile Thr Ala Ile His Ser 
    530                 535                 540                 


Ala Cys Ala Thr Ala Val Ala Arg His His His Lys Glu Asp Thr Leu 
545                 550                 555                 560 


Arg Leu Leu Lys Ser Glu Ile Lys Lys Leu Glu Gln Lys Ile Asp Met 
                565                 570                 575     


Asp Glu Lys Met Lys Lys Met Gly Glu Met Gln Leu Ser Ser Val Thr 
            580                 585                 590         


Asp Ser Lys Lys Lys Lys Thr Ile Leu Asp Gln Ile Phe Val Trp Glu 
        595                 600                 605             


Gln Asn Leu Glu Gln Phe Gln Met Asp Leu Phe Arg Phe Arg Cys Tyr 
    610                 615                 620                 


Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Ala Phe Ala Ser Arg Pro Thr Lys Val Ala Met Gly Arg Leu Gly Ile 
                645                 650                 655     


Phe Ser Val Ser Ser Phe His Ala Leu Val Ala Ala Arg Thr Gly Glu 
            660                 665                 670         


Thr Gly Val Arg Arg Arg Thr Gln Ala Met Ser Arg Ser Ala Ser Lys 
        675                 680                 685             


Arg Arg Ser Arg Phe Ser Ser Leu Trp Gly Leu Asp Thr Thr Ser Lys 
    690                 695                 700                 


Lys Lys Gln Gly Arg Pro Ser Ile Asn Gln Val Phe Gly Glu Gly Thr 
705                 710                 715                 720 


Glu Ala Val Lys Lys Ser Leu Glu Gly Ile Phe Asp Asp Ile Val Pro 
                725                 730                 735     


Asp Gly Lys Arg Glu Lys Glu Val Val Leu Pro Asn Val His Gln His 
            740                 745                 750         


Asn Pro Asp Cys Asp Ile Trp Val His Glu Tyr Phe Thr Pro Ser Trp 
        755                 760                 765             


Phe Cys Leu Pro Asn Asn Gln Pro Ala Leu Thr Val Val Arg Pro Gly 
    770                 775                 780                 


Asp Thr Ala Arg Asp Thr Leu Glu Leu Ile Cys Lys Thr His Gln Leu 
785                 790                 795                 800 


Asp His Ser Ala His Tyr Leu Arg Leu Lys Phe Leu Ile Glu Asn Lys 
                805                 810                 815     


Met Gln Leu Tyr Val Pro Gln Pro Glu Glu Asp Ile Tyr Glu Leu Leu 
            820                 825                 830         


Tyr Lys Glu Ile Glu Ile Cys Pro Lys Val Thr Gln Ser Ile His Ile 
        835                 840                 845             


Glu Lys Ser Asp Thr Ala Ala Asp Thr Tyr Gly Phe Ser Leu Ser Ser 
    850                 855                 860                 


Val Glu Glu Asp Gly Ile Arg Arg Leu Tyr Val Asn Ser Val Lys Glu 
865                 870                 875                 880 


Thr Gly Leu Ala Ser Lys Lys Gly Leu Lys Ala Gly Asp Glu Ile Leu 
                885                 890                 895     


Glu Ile Asn Asn Arg Ala Ala Asp Ala Leu Asn Ser Ser Met Leu Lys 
            900                 905                 910         


Asp Phe Leu Ser Gln Pro Ser Leu Gly Leu Leu Val Arg Thr Tyr Pro 
        915                 920                 925             


Glu Leu Glu Glu Gly Val Glu Leu Leu Glu Ser Pro Pro His Arg Val 
    930                 935                 940                 


Asp Gly Pro Ala Asp Leu Gly Glu Ser Pro Leu Ala Phe Leu Thr Ser 
945                 950                 955                 960 


Asn Pro Gly His Ser Leu Cys Ser Glu Gln Gly Ser Ser Ala Glu Thr 
                965                 970                 975     


Ala Pro Glu Glu Thr Glu Gly Pro Asp Leu Glu Ser Ser Asp Glu Thr 
            980                 985                 990         


Asp His Ser Ser Lys Ser Thr Glu  Gln Val Ala Ala Phe  Cys Arg Ser 
        995                 1000                 1005             


Leu His  Glu Met Asn Pro Ser  Asp Gln Ser Pro Ser  Pro Gln Asp 
    1010                 1015                 1020             


Ser Thr  Gly Pro Gln Leu Ala  Thr Met Arg Gln Leu  Ser Asp Ala 
    1025                 1030                 1035             


Asp Lys  Leu Arg Lys Val Ile  Cys Glu Leu Leu Glu  Thr Glu Arg 
    1040                 1045                 1050             


Thr Tyr  Val Lys Asp Leu Asn  Cys Leu Met Glu Arg  Tyr Leu Lys 
    1055                 1060                 1065             


Pro Leu  Gln Lys Glu Thr Phe  Leu Thr Gln Asp Glu  Leu Asp Val 
    1070                 1075                 1080             


Leu Phe  Gly Asn Leu Thr Glu  Met Val Glu Phe Gln  Val Glu Phe 
    1085                 1090                 1095             


Leu Lys  Thr Leu Glu Asp Gly  Val Arg Leu Val Pro  Asp Leu Glu 
    1100                 1105                 1110             


Lys Leu  Glu Lys Val Asp Gln  Phe Lys Lys Val Leu  Phe Ser Leu 
    1115                 1120                 1125             


Gly Gly  Ser Phe Leu Tyr Tyr  Ala Asp Arg Phe Lys  Leu Tyr Ser 
    1130                 1135                 1140             


Ala Phe  Cys Ala Ser His Thr  Lys Val Pro Lys Val  Leu Val Lys 
    1145                 1150                 1155             


Ala Lys  Thr Asp Thr Ala Phe  Lys Ala Phe Leu Asp  Ala Gln Asn 
    1160                 1165                 1170             


Pro Lys  Gln Gln His Ser Ser  Thr Leu Glu Ser Tyr  Leu Ile Lys 
    1175                 1180                 1185             


Pro Ile  Gln Arg Ile Leu Lys  Tyr Pro Leu Leu Leu  Arg Glu Leu 
    1190                 1195                 1200             


Phe Ala  Leu Thr Asp Ala Glu  Ser Glu Glu His Tyr  His Leu Asp 
    1205                 1210                 1215             


Val Ala  Ile Lys Thr Met Asn  Lys Val Ala Ser His  Ile Asn Glu 
    1220                 1225                 1230             


Met Gln  Lys Ile His Glu Glu  Phe Gly Ala Val Phe  Asp Gln Leu 
    1235                 1240                 1245             


Ile Ala  Glu Gln Thr Gly Glu  Lys Lys Glu Val Ala  Asp Leu Ser 
    1250                 1255                 1260             


Met Gly  Asp Leu Leu Leu His  Thr Thr Val Ile Trp  Leu Asn Pro 
    1265                 1270                 1275             


Pro Ala  Ser Leu Gly Lys Trp  Lys Lys Glu Pro Glu  Leu Ala Ala 
    1280                 1285                 1290             


Phe Val  Phe Lys Thr Ala Val  Val Leu Val Tyr Lys  Asp Gly Ser 
    1295                 1300                 1305             


Lys Gln  Lys Lys Lys Leu Val  Gly Ser His Arg Leu  Ser Ile Tyr 
    1310                 1315                 1320             


Glu Asp  Trp Asp Pro Phe Arg  Phe Arg His Met Ile  Pro Thr Glu 
    1325                 1330                 1335             


Ala Leu  Gln Val Arg Ala Leu  Ala Ser Ala Asp Ala  Glu Ala Asn 
    1340                 1345                 1350             


Ala Val  Cys Glu Ile Val His  Val Lys Ser Glu Ser  Glu Gly Arg 
    1355                 1360                 1365             


Pro Glu  Arg Val Phe His Leu  Cys Cys Ser Ser Pro  Glu Ser Arg 
    1370                 1375                 1380             


Lys Asp  Phe Leu Lys Ala Val  His Ser Ile Leu Arg  Asp Lys His 
    1385                 1390                 1395             


Arg Arg  Gln Leu Leu Lys Thr  Glu Ser Leu Pro Ser  Ser Gln Gln 
    1400                 1405                 1410             


Tyr Val  Pro Phe Gly Gly Lys  Arg Leu Cys Ala Leu  Lys Gly Ala 
    1415                 1420                 1425             


Arg Pro  Ala Met Ser Arg Ala  Val Ser Ala Pro Ser  Lys Ser Leu 
    1430                 1435                 1440             


Gly Arg  Arg Arg Arg Arg Leu  Ala Arg Asn Arg Phe  Thr Ile Asp 
    1445                 1450                 1455             


Ser Asp  Ala Val Ser Ala Ser  Ser Pro Glu Lys Glu  Ser Gln Gln 
    1460                 1465                 1470             


Pro Pro  Gly Gly Gly Asp Thr  Asp Arg Trp Val Glu  Glu Gln Phe 
    1475                 1480                 1485             


Asp Leu  Ala Gln Tyr Glu Glu  Gln Asp Asp Ile Lys  Glu Thr Asp 
    1490                 1495                 1500             


Ile Leu  Ser Asp Asp Asp Glu  Phe Cys Glu Ser Val  Lys Gly Ala 
    1505                 1510                 1515             


Ser Val  Asp Arg Asp Leu Gln  Glu Arg Leu Gln Ala  Thr Ser Ile 
    1520                 1525                 1530             


Ser Gln  Arg Glu Arg Gly Arg  Lys Thr Leu Asp Ser  His Ala Ser 
    1535                 1540                 1545             


Arg Met  Ala Gln Leu Lys Lys  Gln Ala Ala Leu Ser  Gly Ile Asn 
    1550                 1555                 1560             


Gly Gly  Leu Glu Ser Ala Ser  Glu Glu Val Ile Trp  Val Arg Arg 
    1565                 1570                 1575             


Glu Asp  Phe Ala Pro Ser Arg  Lys Leu Asn Thr Glu  Ile 
    1580                 1585                 1590     


<210>  90
<211>  7597
<212>  DNA
<213>  homo sapiens

<400>  90
gagacagtaa ggagccaggg gaacagagag aattgtgggg cagcaccgct ccttgggtcc       60

ccactcccca tttctcattg cttggaaatc catgccaaga tgcctgcctt ccttggtcta      120

aagtgtctgg ggaaattgtg cagctctgag aaaagcaaag tcacctcatc tgagagaacc      180

agtgccaggg gctcgaacag aaagagactg attgttgagg accggagggt ctctgggacc      240

tccttcaccg ctcataggcg tgccactatc actcatttgc tgtatctctg tcccaaggac      300

tactgcccac gtgggcgtgt atgtaacagc gttgatcctt ttgtggccca ccctcaggac      360

cctcaccacc catcagagaa gcctgtcatt cactgccata aatgtgggga gccttgcaag      420

ggtgaagtgc ttcgggtcca gaccaaacat ttccacatca agtgtttcac ctgcaaagtg      480

tgtggctgtg acctggcaca agggggcttc ttcataaaga acggagagta tctctgcacc      540

ctggactacc agcggatgta cgggacacgc tgccatggct gtggggagtt cgtggagggc      600

gaagtggtga ctgctctggg caagacctac catcccaatt gctttgcttg tactatctgc      660

aagcgcccgt ttccacccgg agaccgagtc acattcaatg ggagagactg cctttgtcaa      720

ctctgtgcac agccgatgtc gtccagtccg aaagaaacca ccttctccag caattgtgcc      780

ggctgcggaa gagatatcaa gaatgggcag gcgctgctgg cgctggataa gcagtggcac      840

ttggggtgct ttaaatgcaa gtcctgcggg aaggtcctca ccggggagta catcagcaag      900

gatggtgctc cgtactgtga aaaggactac cagggactct ttggggtgaa atgtgaggcg      960

tgtcaccagt ttatcacagg gaaagtcctg gaggcaggtg acaaacatta ccaccccagc     1020

tgtgcacgat gcagcagatg caaccagatg ttcacagaag gagaggaaat gtatcttcaa     1080

ggctccaccg tttggcatcc cgactgtaag caatctacga agaccgagga aaagctgcgg     1140

cctaccagga catcctcgga aagtatttat tctaggccag gctccagtat tcctggctca     1200

ccaggtcata ctatctatgc aaaagtagac aatgagatcc tggattacaa ggatttagca     1260

gccattccga aggtcaaggc aatttatgac attgaacgtc cagatcttat tacctatgag     1320

cctttctaca cttcgggcta tgatgacaaa caggagagac agagccttgg agagtctccg     1380

aggactttgt ctcctactcc atcagcagaa gggtaccagg atgttcggga tcggatgatc     1440

catcggtcca cgagccaggg ctccatcaac tcccctgtgt acagccgcca cagctacact     1500

ccaaccacgt cccgctctcc ccagcatttc cacagacctg gcaatgagcc gtccagcggc     1560

cggaactccc ctctccctta ccggccagac agccgccctc taactccaac ttacgctcag     1620

gcccctaaac atttccatgt tccagatcaa ggaatcaaca tttaccgaaa gccacccatc     1680

tacaaacagc atgctgcctt ggcagcccag agcaagtcct cagaagatat catcaagttt     1740

tccaagttcc cagcagccca ggcaccagac cccagcgaga caccaaagat tgagacggac     1800

cactggcctg gtcccccctc atttgctgtc gtaggacctg acatgaaacg cagatctagt     1860

ggcagagagg aagatgatga ggaacttctg agacgtcggc agcttcaaga agagcaatta     1920

atgaagctta actcaggcct gggacagttg atcttgaaag aagagatgga gaaagagagc     1980

cgggaaaggt catctctgtt agccagtcgc tacgattctc ccatcaactc agcttcacat     2040

attccatcat ctaaaactgc atctctccct ggctatggaa gaaatgggct tcaccggcct     2100

gtttctaccg acttcgctca gtataacagc tatggggatg tcagcggggg agtgcgagat     2160

taccagacac tcccagatgg ccacatgcct gcaatgagaa tggaccgagg agtgtctatg     2220

cccaacatgt tggaaccaaa gatatttcca tatgaaatgc tcatggtgac caacagaggg     2280

cgaaacaaaa tcctcagaga ggtggacaga accaggctgg agcgccactt agcccctgaa     2340

gtgtttcggg aaatctttgg aatgtccata caggagtttg acaggttacc tctttggaga     2400

cgcaacgaca tgaagaaaaa agcaaaactc ttctaagtcc cactcgtgaa tggcaattag     2460

agaaaggact gacagtggcg gtgccccata ggatgtcata ttgaggccca aacttgattg     2520

gagaatttgc aaactaccgt cgctcagcaa caccaaaaag agaaagtctg gttaaaacac     2580

catgagtcaa atgtcgggcc agccaacagt aacacttgcc aagaagcatg gcgtagaaat     2640

ttctatgttc cgaaacacag agtagtgtcc acatgtgagc ttttcacatt accttatgta     2700

tacaacagga gctgcgttgt tttcttcttt ttcttttcct ttatctgttg tccaacaaca     2760

gtgctgactg tccggataag agctggcaag tgcccttagg atgccgcatg ggaaaaatcg     2820

gttatcataa tttcaaagta taaatatatt tattaagtag cgctgcggct aagaaggaag     2880

agtgaggggt ctgtccatgg ggtggcagtg atttcacacc cgcctttctt gaatggcttc     2940

gtgttactca gccgtgccct ggcaggaatg gaactccatc agggaacagg gcagctctgt     3000

ttgaatgggg tgaaaaacag caaaattaat tcttagcaag ctccttgttc tctactgttc     3060

accgggacct ggctggcaaa tgacttagct attagtatat ttaaaaactg ttcaaaagca     3120

aaagagaagg aacaggaatg aaaggaaacc ttcccttaac tctttctgct tcccatagca     3180

ggtctggttc ctgctccccg cctaggacag gagctgtctg gagctccacc tttgcaaaga     3240

aaggaaaaac acaaattgcc cccagattgg cccagtggca tgccattagg tgattttgca     3300

taggggccat atcattcatg gccaaaaaaa accaaaaagc aaaaaacaaa aacaagtccc     3360

atgtcctact gactctagtt cttccagtcg ttatcctctg ctgtctctct ggcatcctat     3420

gaatcagatc aagcccatgc tgttgttggt ttttaaggtt tctttcaata ataggctaag     3480

gaaagacatg tttttctctt ttaaatctct gcaactccaa agtagactcc ttcgaacgta     3540

tttaatttgg ccttttcagc tttcttcttg cccagctctg tcgaattcat gggtgtgtgt     3600

gcacatgttg gtttcactca cccagagtaa ttttgtgagc atgcatgtgc tttttaattt     3660

ctgcttgaat gtttgtcctg ctgtgttgca gcttctaaag acattgtcac cgagtgtgtg     3720

tgactcaaag atcaagagtg aggctaaact gcgaccccaa catcacttcc ttcatggaaa     3780

ggtgttggcg ctgatgtagc tcatggaagg atcagactgg gaaccacaga ggaaggatga     3840

ggtgggatgt ggaggtcaga gcatctcacg agagtccctc aggctctgca acactagatt     3900

cgaatatgag cctagggttt ccccaacacg tgcgtgcata tgaaaccaca tcatgattcc     3960

cgacgtgagt tagatgaggg agagtttgtg taactccaca cccaggaggg taagccactt     4020

tattatcatg ctttggggct gtgcttaaga atttaagctc tgttttaaag ccgaagaaga     4080

aaacatttga atttaccttc atatgccact aagaacaaaa gctctgaagt tcttcctgct     4140

ggcaccaaat attaggatta caagctgtct ctctgacacc agtggtaaaa aagcaagtag     4200

aatagtttct gagtctgtgt tgcagcctct gacacgtggc tcaccgctgt catttggggg     4260

atggaatgaa cagtcactgt tctatagcat cctcctgtgc tcttacctaa ggaatctaaa     4320

ttgtcctagc cttccattgc tatgcactga atgaggacta ctctcgtgtg tgtgtgtgtg     4380

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggat ctactaacat gtttagcaaa     4440

tggctctgac agggtggcca tgagcagatg agaccagctc ttgcttggtt ggaagccaca     4500

ctgcagtttg cagtttagcc tttggtgtct cagtggcttc ttgcttattc catgcttttt     4560

ctatcccatc ctctctctgt gccctcctgc aatggcagcc ttggcacaat gcctgggtgt     4620

cctcatcctt gctttactct ggaaagtgtg gggatggaga ggatggtgca tttccagtgc     4680

ttccttacct gtcaataaca atggtggcca cctgggtccc agcacttggc tggtggagag     4740

atttttttca ttatggagct aataaagggt ccctacgttt tacattgatt aatgaattat     4800

cacccagaca tgtgcagatg aaatgtcaat ataagaaaaa tcaaggtatt tgggaaacat     4860

gggcataatc aggtagtttt gctaaaattc ctcttccttg gtctacataa agaagacatg     4920

ggtctgtcat agaatgggga cattagactg aaaactggga caaccccctt ccttatttta     4980

tagagactag gagttaaggg gcctgcctaa gattgcagtg ataaagaact gaaccctaaa     5040

tcagctccca ctaatgaaac cctgctttcc ttgtatcttt taaactcagt tctgcatcca     5100

acttgagaag aaaaaaagct tctttccata tcaagtacca tatgagttca tttaaactgc     5160

accttgcaga aatgcattgc cagaaagcac cagtagcctc ctatctgcaa gcagagtagt     5220

gctctgctct ggggaggggt cattggaaac cataatgcag agtgggcccc ctactccatt     5280

tcccagcaaa aggctccagc tggagggatg ggttgtgggg caacctggtt cctgctaact     5340

gccagattga atgtgtgggc tagaatgcct gcacatttag ttaaactggg ctcagcatgc     5400

ttgtcctcaa aatgtccatc ctggtcacag cacacaagat ggctattggt ctgcttttac     5460

cctaccctgt actatacatg aaaattccag ttattaacac actcaaactg gtggagcttg     5520

ttcaccctag gaaggggatt gtatatatgg caggcttccc tggtgccgat gtaaagggct     5580

acatttggga acatttgact tccttgggac tcttaagtgc ataatgatgg catgaagtaa     5640

aaggggcctc aatgatgata ggaaaatcag ttcttttaaa atttcttcaa gaaaatccag     5700

gctatcacat agtctttctg tgtgacttat taggagatag gaagagcatt gggaaacttg     5760

cacagctagc tatgcatcta cattttggtt tggggttagt tatgaaatgt tcttaatatg     5820

acgtgttcaa taacttcaca taaacttcct gttctccaaa acctcaaaga gatagagtta     5880

atgagttgtt gttttttttt aaatgggggt agttttctat ctgtcatggg ctctagcatc     5940

tactccgcta cccaattctg tcatctccaa gctgagtttc ctcttctgag gcagaggctg     6000

gagcagttct ttttcagttc tcatcctctc catcccaatc cagtatatca atcaactcta     6060

actcggagac gtctagctgg caatgtttct aaaactttca ctggatttct ttagacattg     6120

aagcaaacat ttttttctaa gaattgcttc tcagatgatg atatcaaatg tatatgcttt     6180

tgcaagtttg aaaagttcaa attaaccact tttgactagg taagtctttc taaaaaccat     6240

ttaaagctaa ctgggtctta gcatcctcct gtgtatggaa gagacaggtg accgctccag     6300

gttgggtgct cacagaaccc ttttcctgac tctcatggaa gatggtggaa ggaaaataga     6360

ctgtctcatc aaccctcctg tgtcctctga agcaatctca gtttttatta accacctctt     6420

ctgtgtttct ggtagctatt taacctgtat ttaatctgta cttcctatgc cagcctcaat     6480

tttatttgat ttttacaatt attctcttct aaccaatgaa gtgtttgtca gtatgcccca     6540

aagcttgctc ttttgtgctc ccttttgaat aactttctat ccagaaaaag agattatttg     6600

ggacttgaga tttgcagtga taccaactta tagcaatgat gtactttaag ggaactaccc     6660

aactatgttg tgatagaaga aagagaaacc ttcactttgg catttttttt taatcactgt     6720

ttatttttct gtttgcggcc caggaagcag tgggaggtgg tggcagatat gctttgcata     6780

tggattgtta tgtttttatt tgggcaagtt taatcatgga aaactcaaaa agaagggggg     6840

aaatggtcag tttaagccaa aagaaacttt ctaaacaatg tataggtaca cagcaaaatt     6900

aaacaaatcc aacaatttct gaagcttagt gtaattgagt ggtggttgtt attcaataaa     6960

attattccca aaagtgtttc tcctaagagt gcagttccca tgagtcactt cctgaaccca     7020

ttgaccaaag gtggacagag acaatcctgt agaccttgac attcagaaag atgtgagctg     7080

cttactgatc atatatgcat acgtttcttt acagcagagg aaaccattgt ccacaaaact     7140

gatgttcttt tggggtttta tgtacagact tgtccaatca tgtgtgtggt tcctgcgagt     7200

tgctgatgac tccgcattga agctctctga gttctttgat tttaagttgg gtttatggaa     7260

ttttttcaaa tgttggaagg tgtgtggttc ttcctgccct ccctcccctt ttggaaatat     7320

gaaagcaaat gtttagaaga attccttttg aaaagctgtg tcgtgttccc tgtgaaactg     7380

agcaggtgtg tgttggcgcg ctaagtgcca catgcttgtg tgtagaggag gaggtggccc     7440

tgccggctcc gcgctgctgt gcctgtgatc cctacctgct ccccgctcct gttgccagca     7500

gcactcactg cactcctttg tcatatactc tgcatcactg tcatactcac aacttcgtga     7560

ataaagttgt gtgctttatt cgtagaaaaa aaaaaaa                              7597


<210>  91
<211>  778
<212>  PRT
<213>  homo sapiens

<400>  91

Met Pro Ala Phe Leu Gly Leu Lys Cys Leu Gly Lys Leu Cys Ser Ser 
1               5                   10                  15      


Glu Lys Ser Lys Val Thr Ser Ser Glu Arg Thr Ser Ala Arg Gly Ser 
            20                  25                  30          


Asn Arg Lys Arg Leu Ile Val Glu Asp Arg Arg Val Ser Gly Thr Ser 
        35                  40                  45              


Phe Thr Ala His Arg Arg Ala Thr Ile Thr His Leu Leu Tyr Leu Cys 
    50                  55                  60                  


Pro Lys Asp Tyr Cys Pro Arg Gly Arg Val Cys Asn Ser Val Asp Pro 
65                  70                  75                  80  


Phe Val Ala His Pro Gln Asp Pro His His Pro Ser Glu Lys Pro Val 
                85                  90                  95      


Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly Glu Val Leu Arg 
            100                 105                 110         


Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr Cys Lys Val Cys 
        115                 120                 125             


Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys Asn Gly Glu Tyr 
    130                 135                 140                 


Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr Arg Cys His Gly 
145                 150                 155                 160 


Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala Leu Gly Lys Thr 
                165                 170                 175     


Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys Arg Pro Phe Pro 
            180                 185                 190         


Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys Leu Cys Gln Leu 
        195                 200                 205             


Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr Thr Phe Ser Ser 
    210                 215                 220                 


Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly Gln Ala Leu Leu 
225                 230                 235                 240 


Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys Cys Lys Ser Cys 
                245                 250                 255     


Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp Gly Ala Pro Tyr 
            260                 265                 270         


Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys Cys Glu Ala Cys 
        275                 280                 285             


His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly Asp Lys His Tyr 
    290                 295                 300                 


His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln Met Phe Thr Glu 
305                 310                 315                 320 


Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp His Pro Asp Cys 
                325                 330                 335     


Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro Thr Arg Thr Ser 
            340                 345                 350         


Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile Pro Gly Ser Pro 
        355                 360                 365             


Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile Leu Asp Tyr Lys 
    370                 375                 380                 


Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr Asp Ile Glu Arg 
385                 390                 395                 400 


Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser Gly Tyr Asp Asp 
                405                 410                 415     


Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg Thr Leu Ser Pro 
            420                 425                 430         


Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp Arg Met Ile His 
        435                 440                 445             


Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val Tyr Ser Arg His 
    450                 455                 460                 


Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His Phe His Arg Pro 
465                 470                 475                 480 


Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu Pro Tyr Arg Pro 
                485                 490                 495     


Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala Pro Lys His Phe 
            500                 505                 510         


His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys Pro Pro Ile Tyr 
        515                 520                 525             


Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser Ser Glu Asp Ile 
    530                 535                 540                 


Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro Asp Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro Pro Ser Phe Ala 
                565                 570                 575     


Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly Arg Glu Glu Asp 
            580                 585                 590         


Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu Glu Gln Leu Met 
        595                 600                 605             


Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys Glu Glu Met Glu 
    610                 615                 620                 


Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser Arg Tyr Asp Ser 
625                 630                 635                 640 


Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys Thr Ala Ser Leu 
                645                 650                 655     


Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val Ser Thr Asp Phe 
            660                 665                 670         


Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly Val Arg Asp Tyr 
        675                 680                 685             


Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg Met Asp Arg Gly 
    690                 695                 700                 


Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe Pro Tyr Glu Met 
705                 710                 715                 720 


Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu Arg Glu Val Asp 
                725                 730                 735     


Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val Phe Arg Glu Ile 
            740                 745                 750         


Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro Leu Trp Arg Arg 
        755                 760                 765             


Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
    770                 775             


<210>  92
<211>  1479
<212>  DNA
<213>  homo sapiens

<400>  92
actgccccag cctcaggctc tgtgcatctc ccccgagccc ccaccacata tgtgcggagg       60

cccctggggg cccaggcctg tcctcagtcc cgactgggct ctacctgagg accctgggga      120

gcctgggcct ggccctcctc agagcttggg gcttccttgg tcgcacccac cacctgcctg      180

cccactggtc agccttcagg gaccctgagc accgcctggt ctctttcctg tggccagccc      240

agaactgaag cgctgcggca tggcgcgcgc ctgcctccag gccgtcaagt acctcatgtt      300

cgccttcaac ctgctcttct ggctgggagg ctgtggcgtg ctgggtgtcg gcatctggct      360

ggccgccaca caggggagct tcgccacgct gtcctcttcc ttcccgtccc tgtcggctgc      420

caacttgctc atcatcaccg gcgcctttgt catggccatc ggcttcgtgg gctgcctggg      480

tgccatcaag gagaacaagt gcctcctgct cactttcttc ctgctgctgc tgctggtgtt      540

cctgctggag gccaccatcg ccatcctctt cttcgcctac acggacaaga ttgacaggta      600

tgcccagcaa gacctgaaga aaggcttgca cctgtacggc acgcagggca acgtgggcct      660

caccaacgcc tggagcatca tccagaccga cttccgctgc tgtggcgtct ccaactacac      720

tgactggttc gaggtgtaca acgccacgcg ggtacctgac tcctgctgct tggagttcag      780

tgagagctgt gggctgcacg cccccggcac ctggtggaag gcgccgtgct acgagacggt      840

gaaggtgtgg cttcaggaga acctgctggc tgtgggcatc tttgggctgt gcacggcgct      900

ggtgcagatc ctgggcctga ccttcgccat gaccatgtac tgccaagtgg tcaaggcaga      960

cacctactgc gcgtaggccg cccaccgccc gcttctctgc caaaaggacg cccacgggga     1020

gatggccgca cccacagctg cctttcccac caccagcctc ggtgctctgc cccatgctgg     1080

gaggagggag ggagggacag gtgcctggag cccccggaac cctgtttctg gaaggcccta     1140

gctcaggtgg cttcagggcc tccggacccc ccctgggagg ggtggccacg tgctggctgc     1200

ggaacccagg gcaggggtgg gaggggcctc cagcactttt tatatttacg tattctccaa     1260

agcagtgttc acacgggagc cagcctgtgg cccccagcct cctggaaaac aggttggcgc     1320

tggaggagcc gggtcttggc atcctggagg tggccccact ggtcctggtg ctccaggcgg     1380

ggccgtggac ccctcaccta cattccatag tgggcccgtg gggctcctgg tgcatcttaa     1440

taaagtgtga gcagcaacct tgaaaaaaaa aaaaaaaaa                            1479


<210>  93
<211>  238
<212>  PRT
<213>  homo sapiens

<400>  93

Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Leu Gly Gly Cys Gly Val Leu Gly Val Gly Ile 
            20                  25                  30          


Trp Leu Ala Ala Thr Gln Gly Ser Phe Ala Thr Leu Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Leu Ser Ala Ala Asn Leu Leu Ile Ile Thr Gly Ala Phe Val 
    50                  55                  60                  


Met Ala Ile Gly Phe Val Gly Cys Leu Gly Ala Ile Lys Glu Asn Lys 
65                  70                  75                  80  


Cys Leu Leu Leu Thr Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu 
                85                  90                  95      


Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp 
            100                 105                 110         


Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr 
        115                 120                 125             


Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp 
    130                 135                 140                 


Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr 
145                 150                 155                 160 


Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser 
                165                 170                 175     


Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu 
            180                 185                 190         


Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe 
        195                 200                 205             


Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met 
    210                 215                 220                 


Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala 
225                 230                 235             


<210>  94
<211>  2100
<212>  DNA
<213>  homo sapiens

<400>  94
tttccttccc tctccctggg cttgggtctc ccacttgtcc agacagcggc cgggcttgtc       60

acggggctct gtgcagcctt ttccactctc ccggctgcca gcgtcccgcc ccgtcccctc      120

ccagccccca agggaggagg ggagagctgc agagaggagg aggggtcggg gaggccggct      180

ttataaaggc ggctggaaca accctgcccg ccagaccccg tcgcccggat cccctgagct      240

gcccgccatc ccacgtgacc gcgccgcccc ccagctccac cgctgagccc gctcgccatg      300

gccctcttcg gggccctctt cctagcgctg ctggcaggcg cacatgcaga gttcccaggc      360

tgcaagatcc gcgtcacctc caaggcgctg gagctggtga agcaggaggg gctgcgcttt      420

ctggagcaag agctggagac tatcaccatt ccggacctgc ggggcaaaga aggccacttc      480

tactacaaca tctctgaggt gaaggtcaca gagctgcaac tgacatcttc cgagctcgat      540

ttccagccac agcaggagct gatgcttcaa atcaccaatg cctccttggg gctgcgcttc      600

cggagacagc tgctctactg gttcttctat gatgggggct acatcaacgc ctcagctgag      660

ggtgtgtcca tccgcactgg tctggagctc tcccgggatc ccgctggacg gatgaaagtg      720

tccaatgtct cctgccaggc ctctgtctcc agaatgcacg cggccttcgg gggaaccttc      780

aagaaggtgt atgattttct ctccacgttc atcacctcag ggatgcgctt cctcctcaac      840

cagcagatct gccctgtcct ctaccacgca gggacggtcc tgctcaactc cctcctggac      900

accgtgcctg tgcgcagttc tgtggacgag cttgttggca ttgactattc cctcatgaag      960

gatcctgtgg cttccaccag caacctggac atggacttcc ggggggcctt cttccccctg     1020

actgagagga actggagcct ccccaaccgg gcagtggagc cccagctgca ggaggaagag     1080

cggatggtgt atgtggcctt ctctgagttc ttcttcgact ctgccatgga gagctacttc     1140

cgggcggggg ccctgcagct gttgctggtg ggggacaagg tgccccacga cctggacatg     1200

ctgctgaggg ccacctactt tgggagcatt gtcctgctga gcccagcagt gattgactcc     1260

ccattgaagc tggagctgcg ggtcctggcc ccaccgcgct gcaccatcaa gccctctggc     1320

accaccatct ctgtcactgc tagcgtcacc attgccctgg tcccaccaga ccagcctgag     1380

gtccagctgt ccagcatgac tatggacgcc cgtctcagcg ccaagatggc tctccggggg     1440

aaggccctgc gcacgcagct ggacctgcgc aggttccgaa tctattccaa ccattctgca     1500

ctggagtcgc tggctctgat cccattacag gcccctctga agaccatgct gcagattggg     1560

gtgatgccca tgctcaatga gcggacctgg cgtggggtgc agatcccact acctgagggc     1620

atcaactttg tgcatgaggt ggtgacgaac catgcgggat tcctcaccat cggggctgat     1680

ctccactttg ccaaagggct gcgagaggtg attgagaaga accggcctgc tgatgtcagg     1740

gcgtccactg cccccacacc gtccacagca gctgtctgag ccctcaatcc ccaagctggc     1800

agctgtcatt caggacccca acccctctca gcccctcttt tcccacattc atagcctgta     1860

gtgccccctc taacccccag tgccacagag aagacgggat ttgaagctgt acccaattta     1920

attccataat caatctatca attacagtcc gtccaccacc tccctgtggg ctgtcctgag     1980

ctctgttggg ttcctgggat ggaatcagtg catcataaag ggcattcttt aagcagagaa     2040

ggggccaggc caccccattc aggaactgct gcgggaataa agtgctaact tgcccccagg     2100


<210>  95
<211>  493
<212>  PRT
<213>  homo sapiens

<400>  95

Met Ala Leu Phe Gly Ala Leu Phe Leu Ala Leu Leu Ala Gly Ala His 
1               5                   10                  15      


Ala Glu Phe Pro Gly Cys Lys Ile Arg Val Thr Ser Lys Ala Leu Glu 
            20                  25                  30          


Leu Val Lys Gln Glu Gly Leu Arg Phe Leu Glu Gln Glu Leu Glu Thr 
        35                  40                  45              


Ile Thr Ile Pro Asp Leu Arg Gly Lys Glu Gly His Phe Tyr Tyr Asn 
    50                  55                  60                  


Ile Ser Glu Val Lys Val Thr Glu Leu Gln Leu Thr Ser Ser Glu Leu 
65                  70                  75                  80  


Asp Phe Gln Pro Gln Gln Glu Leu Met Leu Gln Ile Thr Asn Ala Ser 
                85                  90                  95      


Leu Gly Leu Arg Phe Arg Arg Gln Leu Leu Tyr Trp Phe Phe Tyr Asp 
            100                 105                 110         


Gly Gly Tyr Ile Asn Ala Ser Ala Glu Gly Val Ser Ile Arg Thr Gly 
        115                 120                 125             


Leu Glu Leu Ser Arg Asp Pro Ala Gly Arg Met Lys Val Ser Asn Val 
    130                 135                 140                 


Ser Cys Gln Ala Ser Val Ser Arg Met His Ala Ala Phe Gly Gly Thr 
145                 150                 155                 160 


Phe Lys Lys Val Tyr Asp Phe Leu Ser Thr Phe Ile Thr Ser Gly Met 
                165                 170                 175     


Arg Phe Leu Leu Asn Gln Gln Ile Cys Pro Val Leu Tyr His Ala Gly 
            180                 185                 190         


Thr Val Leu Leu Asn Ser Leu Leu Asp Thr Val Pro Val Arg Ser Ser 
        195                 200                 205             


Val Asp Glu Leu Val Gly Ile Asp Tyr Ser Leu Met Lys Asp Pro Val 
    210                 215                 220                 


Ala Ser Thr Ser Asn Leu Asp Met Asp Phe Arg Gly Ala Phe Phe Pro 
225                 230                 235                 240 


Leu Thr Glu Arg Asn Trp Ser Leu Pro Asn Arg Ala Val Glu Pro Gln 
                245                 250                 255     


Leu Gln Glu Glu Glu Arg Met Val Tyr Val Ala Phe Ser Glu Phe Phe 
            260                 265                 270         


Phe Asp Ser Ala Met Glu Ser Tyr Phe Arg Ala Gly Ala Leu Gln Leu 
        275                 280                 285             


Leu Leu Val Gly Asp Lys Val Pro His Asp Leu Asp Met Leu Leu Arg 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ser Ile Val Leu Leu Ser Pro Ala Val Ile Asp 
305                 310                 315                 320 


Ser Pro Leu Lys Leu Glu Leu Arg Val Leu Ala Pro Pro Arg Cys Thr 
                325                 330                 335     


Ile Lys Pro Ser Gly Thr Thr Ile Ser Val Thr Ala Ser Val Thr Ile 
            340                 345                 350         


Ala Leu Val Pro Pro Asp Gln Pro Glu Val Gln Leu Ser Ser Met Thr 
        355                 360                 365             


Met Asp Ala Arg Leu Ser Ala Lys Met Ala Leu Arg Gly Lys Ala Leu 
    370                 375                 380                 


Arg Thr Gln Leu Asp Leu Arg Arg Phe Arg Ile Tyr Ser Asn His Ser 
385                 390                 395                 400 


Ala Leu Glu Ser Leu Ala Leu Ile Pro Leu Gln Ala Pro Leu Lys Thr 
                405                 410                 415     


Met Leu Gln Ile Gly Val Met Pro Met Leu Asn Glu Arg Thr Trp Arg 
            420                 425                 430         


Gly Val Gln Ile Pro Leu Pro Glu Gly Ile Asn Phe Val His Glu Val 
        435                 440                 445             


Val Thr Asn His Ala Gly Phe Leu Thr Ile Gly Ala Asp Leu His Phe 
    450                 455                 460                 


Ala Lys Gly Leu Arg Glu Val Ile Glu Lys Asn Arg Pro Ala Asp Val 
465                 470                 475                 480 


Arg Ala Ser Thr Ala Pro Thr Pro Ser Thr Ala Ala Val 
                485                 490             


<210>  96
<211>  1038
<212>  DNA
<213>  homo sapiens

<400>  96
atttgaggcc atataaagtc acctgaggcc ctctccacca cagcccacca gtgaccacga       60

aggctgtgct gcttgccctg ttgatggcag gcttggccct gcagccaggc actgccctgc      120

tgtgctactc ctgcaaagcc caggtgagca acgaggactg cctgcaggtg gagaactgca      180

cccagctggg ggagcagtgc tggaccgcgc gcatccgcgc agttggcctc ctgaccgtca      240

tcagcaaagg ctgcagcttg aactgcgtgg atgactcaca ggactactac gtgggcaaga      300

agaacatcac gtgctgtgac accgacttgt gcaacgccag cggggcccat gccctgcagc      360

cggctgctgc catccttgcg ctgctccctg cactcggcct gctgctctgg ggacccggcc      420

agctctaggc tctggggggc cccgctgcag cccacactgg gtgtggtgcc ccaggcctct      480

gtgccactcc tcacacaccc ggcccagtgg gagcctgtcc tggttcctga ggcacatcct      540

aacgcaagtc tgaccatgta tgtctgcgcc cctgtccccc accctgaccc tcccatggcc      600

ctctccagga ctcccacccg gcagatcggc tctattgaca cagatccgcc tgcagatggc      660

ccctccaacc ctctctgctg ctgtttccat ggcccagcat tctccaccct taaccctgtg      720

ctcaggcacc tcttccccca ggaagccttc cctgcccacc ccatctatga cttgagccag      780

gtctggtccg tggtgtcccc cgcacccagc aggggacagg cactcaggag ggcccggtaa      840

aggctgagat gaagtggact gagtagaact ggaggacagg agtcgacgtg agttcctggg      900

agtctccaga gatggggcct ggaggcctgg aggaaggggc caggcctcac attcgtgggg      960

ctccctgaat ggcagcctca gcacagcgta ggcccttaat aaacacctgt tggataagcc     1020

agaaaaaaaa aaaaaaaa                                                   1038


<210>  97
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  97

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  98
<211>  1552
<212>  DNA
<213>  homo sapiens

<400>  98
acagactgca gggctgacta gggttagttt ggaggaggga gtaagaggtg gggaggagga       60

ggcacagtta atggatctgt aaacttgcac cctctttcag agtggtacat ggaagacagc      120

acaaagtgga tccatactct gaaatgcagt aactctgatg cttgaatttg tctcccttct      180

tgccagaaag gattctaata actcggtgtc aaagccaaga cataaactca accccttctc      240

ttccaaaagc ttcacgttac agcatggaag ctgttgccaa gtttgatttc actgcttcag      300

gtgaggatga actgagcttt cacactggag atgttttgaa gattttaagt aaccaagagg      360

agtggtttaa ggcggagctt gggagccagg aaggatatgt gcccaagaat ttcatagaca      420

tccagtttcc caaatggttt cacgaaggcc tctctcgaca ccaggcagag aacttactca      480

tgggcaagga ggttggcttc ttcatcatcc gggccagcca gagctcccca ggggacttct      540

ccatctctgt caggcatgag gatgacgttc aacacttcaa ggtcatgcga gacaacaagg      600

gtaattactt tctgtggact gagaagtttc catccctaaa taagctggta gactactaca      660

ggacaaattc catctccaga cagaagcaga tcttccttag agacagaacc cgagaagacc      720

agggtcaccg gggcaacagc ctggaccgga ggtcccaggg aggcccacac ctcagtgggg      780

ctgtgggaga agaaatccga ccttcgatga accggaagct gtcggatcac cccccgaccc      840

ttcccctgca gcagcaccag caccagccac agcctccgca atatgcccca gcgccccagc      900

agctgcagca gcccccacag cagcgatatc tgcagcacca ccatttccac caggaacgcc      960

gaggaggcag ccttgacata aatgatgggc attgtggcac cggcttgggc agtgaaatga     1020

atgcggccct catgcatcgg agacacacag acccagtgca gctccaggcg gcagggcgag     1080

tgcggtgggc ccgggcgctg tatgactttg aggccctgga ggatgacgag ctggggttcc     1140

acagcgggga ggtggtggag gtcctggata gctccaaccc atcctggtgg accggccgcc     1200

tgcacaacaa gctgggcctc ttccctgcca actacgtggc acccatgacc cgataaactc     1260

ttcaggggac agaagctttt tgtctggagc tgcccacaag aaagagggca aggaaaaaag     1320

gctggactcc atgactatat atacatacat ctatctacat ctgcctgtgt acacacacaa     1380

ctttttatac tagtaattta ttggcaattg ggctggtaat tagttgatgc aaaagggaac     1440

tcaggtggag aataatattg acacttgctt ttctgccccc ctcaggggtg tgtggaaggc     1500

agtgggggag ttgggagggg ggcagggaaa tgaaatggag ttttgtcctg gc             1552


<210>  99
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  99

Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Thr 
            180                 185                 190         


Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr Ala 
        195                 200                 205             


Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu Gln 
    210                 215                 220                 


His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile Asn 
225                 230                 235                 240 


Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala Leu 
                245                 250                 255     


Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg 
            260                 265                 270         


Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp 
        275                 280                 285             


Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser 
    290                 295                 300                 


Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe 
305                 310                 315                 320 


Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
                325                 330 


<210>  100
<211>  1871
<212>  DNA
<213>  homo sapiens

<400>  100
tttgtgcaaa taaggtttct gtggtgagac accagataaa ctcaacttcc tctttcaaca       60

acaaatgtgt cagttatcag caggatccat gccgccagag taaagctttc taccctttac      120

tccctgcaaa gaaacaagag tgcttatccc agctaagctc cagggtaatg ttatcatgac      180

agcttcaact tttagaccac aggcaaatgc tttgttaaaa ctctatgctg gtcattccct      240

tcaggatttg gcactcacca acataccctt ctttcaagtg aaaaggcatc tcttttaatg      300

gtcctgacct ttggaatagg aagcatgtac cctggacaga gcacttcaaa ctagaggaac      360

cataaatcca tggctaacct tgacaaatac actgaaacat tcaagatggg tagcaacagt      420

accagcactg ctgagattta ctgtaatgtc actaatgtga aatttcaata ctccctctat      480

gcaaccacct atatcctcat attcattcct ggtcttctgg ctaacagtgc agccttgtgg      540

gttctgtgcc gcttcatcag caagaaaaat aaagccatca ttttcatgat caacctctct      600

gtggctgacc ttgctcatgt attatcttta cccctccgga tttactatta catcagccac      660

cactggcctt tccagagagc cctttgcctg ctctgcttct acctgaagta tctcaacatg      720

tatgccagca tttgtttcct gacgtgcatc agtcttcaaa ggtgcttttt tctcctcaag      780

cccttcaggg ccagagactg gaagcgtagg tacgatgtgg gcatcagtgc tgccatctgg      840

atcgttgtgg ggactgcctg tttgccattt cccatcctga gaagcacaga cttaaacaac      900

aacaagtcct gctttgctga tcttggatac aagcaaatga atgcagttgc gttggtcggg      960

atgattacag ttgctgagct tgcaggattt gtgatcccag tgatcatcat cgcatggtgt     1020

acctggaaaa ctactatatc cttgagacag ccaccaatgg ctttccaagg gatcagtgag     1080

aggcagaaag cactgcggat ggtgttcatg tgtgctgcag tcttcttcat ctgcttcact     1140

ccctatcata ttaactttat tttttacacc atggtaaagg aaaccatcat tagcagttgt     1200

cccgttgtcc gaatcgcact gtatttccac cctttttgcc tgtgccttgc aagtctctgc     1260

tgccttttgg atccaattct ttattacttt atggcttcag agtttcgtga ccaactatcc     1320

cgccatggca gttctgtgac ccgctcccgc ctcatgagca aggagagtgg ttcatcaatg     1380

attggctaaa attaagatat ctctttaatt acgcctttgt ttacctacgt tccttgtctt     1440

tttccaaagg ccagaattgt caaccaattt ctttaattga acattgtaaa aaacaggaat     1500

aagtactttt gtgtaatatt cacagtcaac aggggtgtga tggtgaaggc agagtgtgaa     1560

aaacgtgaga gaggaagaga aaatagattt acctgattcc tctttaaaat tcaagccact     1620

ttcttattta agaaacctag atcaagtttt tacagatgta aataaaagtt gaatagttta     1680

ccttaaattt ttttcaataa gtaagttatt gttaataatg cacagtaaat atgtgaattt     1740

ttcctagatg taaaaaaaaa aatctttcat ataaagacct taaattctga aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa a                                                          1871


<210>  101
<211>  339
<212>  PRT
<213>  homo sapiens

<400>  101

Met Ala Asn Leu Asp Lys Tyr Thr Glu Thr Phe Lys Met Gly Ser Asn 
1               5                   10                  15      


Ser Thr Ser Thr Ala Glu Ile Tyr Cys Asn Val Thr Asn Val Lys Phe 
            20                  25                  30          


Gln Tyr Ser Leu Tyr Ala Thr Thr Tyr Ile Leu Ile Phe Ile Pro Gly 
        35                  40                  45              


Leu Leu Ala Asn Ser Ala Ala Leu Trp Val Leu Cys Arg Phe Ile Ser 
    50                  55                  60                  


Lys Lys Asn Lys Ala Ile Ile Phe Met Ile Asn Leu Ser Val Ala Asp 
65                  70                  75                  80  


Leu Ala His Val Leu Ser Leu Pro Leu Arg Ile Tyr Tyr Tyr Ile Ser 
                85                  90                  95      


His His Trp Pro Phe Gln Arg Ala Leu Cys Leu Leu Cys Phe Tyr Leu 
            100                 105                 110         


Lys Tyr Leu Asn Met Tyr Ala Ser Ile Cys Phe Leu Thr Cys Ile Ser 
        115                 120                 125             


Leu Gln Arg Cys Phe Phe Leu Leu Lys Pro Phe Arg Ala Arg Asp Trp 
    130                 135                 140                 


Lys Arg Arg Tyr Asp Val Gly Ile Ser Ala Ala Ile Trp Ile Val Val 
145                 150                 155                 160 


Gly Thr Ala Cys Leu Pro Phe Pro Ile Leu Arg Ser Thr Asp Leu Asn 
                165                 170                 175     


Asn Asn Lys Ser Cys Phe Ala Asp Leu Gly Tyr Lys Gln Met Asn Ala 
            180                 185                 190         


Val Ala Leu Val Gly Met Ile Thr Val Ala Glu Leu Ala Gly Phe Val 
        195                 200                 205             


Ile Pro Val Ile Ile Ile Ala Trp Cys Thr Trp Lys Thr Thr Ile Ser 
    210                 215                 220                 


Leu Arg Gln Pro Pro Met Ala Phe Gln Gly Ile Ser Glu Arg Gln Lys 
225                 230                 235                 240 


Ala Leu Arg Met Val Phe Met Cys Ala Ala Val Phe Phe Ile Cys Phe 
                245                 250                 255     


Thr Pro Tyr His Ile Asn Phe Ile Phe Tyr Thr Met Val Lys Glu Thr 
            260                 265                 270         


Ile Ile Ser Ser Cys Pro Val Val Arg Ile Ala Leu Tyr Phe His Pro 
        275                 280                 285             


Phe Cys Leu Cys Leu Ala Ser Leu Cys Cys Leu Leu Asp Pro Ile Leu 
    290                 295                 300                 


Tyr Tyr Phe Met Ala Ser Glu Phe Arg Asp Gln Leu Ser Arg His Gly 
305                 310                 315                 320 


Ser Ser Val Thr Arg Ser Arg Leu Met Ser Lys Glu Ser Gly Ser Ser 
                325                 330                 335     


Met Ile Gly 
            


<210>  102
<211>  10275
<212>  DNA
<213>  homo sapiens

<400>  102
actcccaccc taagtgctgc agactcttcc ctgaagctgc cggctgaggc cggagctgcc       60

gcctccatga gaggcttcct cctacacccc agggccagag gaccctttgc caccagagtg      120

agatcctaga gaccatcatc ctggtaaatc ccagtgcaga cagcatcagc tctgaggttc      180

atcatcttct tagcagctca tcagcttata aactactaat cttgagtggg caaagtttag      240

agcctggggg agacctcatc ctacagagtg gcacctactc atatgaaaac tttgcccagg      300

tccttcacaa ccccgagatt tcccaattgc tcagcaatag agaccctggg atacaggcct      360

tccttaccgt gtcctgctta ggggaaggtg attggagcca cctgggatta tccagttccc      420

aagagaccct gcacctccgg ctaaaccctg agcccactct gcccaccatg gacggcgtgg      480

ctgagttctc cgagtatgtc tctgagactg tggacgtgcc atccccattt gacctactag      540

agccccccac ctcagggggc ttcctcaagc tctccaagcc ttgttgctac atcttcccag      600

gtggtcgtgg ggactctgcc ctctttgctg tcaatggttt caacatcctg gtggatggtg      660

gctctgatcg caagtcctgt ttttggaagc tggtacggca cttggaccgc attgactcgg      720

tgctactcac acacattggg gcagacaacc tgccaggcat caatggacta ctgcagcgca      780

aagtggcaga gctagaggag gagcagtccc agggctctag cagttacagc gactgggtga      840

agaaccttat ctctcctgag cttggagttg tctttttcaa cgtgcctgag aagctgcggc      900

ttcctgatgc ctcccggaaa gccaagcgta gcattgagga ggcctgcctc actctgcagc      960

acttaaaccg cctgggcatc caggctgagc ctctatatcg tgtggtcagc aataccattg     1020

agccactgac cctcttccac aaaatgggtg tgggccggct ggacatgtat gtcctcaacc     1080

ctgtcaagga cagcaaggag atgcagttcc tcatgcaaaa gtgggcaggc aatagtaaag     1140

ccaagacagg catcgtgctg cccaatggga aggaggctga gatctccgtg ccctacctta     1200

cctctatcac tgctctggtg gtctggctac cagccaatcc cactgagaag attgtgcgtg     1260

tgctttttcc aggaaatgct ccccaaaaca agatcttgga gggcctagaa aagcttcggc     1320

atctggactt cctgcgttac cctgtggcca cgcagaagga cctggcttct ggggctgtgc     1380

ctaccaacct caagcccagc aaaatcaaac agcgggctga tagcaaggag agcctcaaag     1440

ccactaccaa gacggccgtg agcaagttgg ccaaacggga ggaggtggta gaagagggag     1500

ccaaggaggc acgttcagag ctggccaagg agttagccaa gacagagaag aaggcaaaag     1560

agtcatctga gaagccccca gagaagcctg ccaagcctga gagggtgaag acagagtcaa     1620

gtgaggcact gaaggcagag aagcgaaagc tgatcaaaga caaggtaggg aaaaagcacc     1680

ttaaagaaaa gatatcaaag ctggaagaaa aaaaagacaa ggagaaaaaa gagatcaaaa     1740

aggagaggaa agagctcaag aaggatgaag gaaggaagga ggagaagaag gatgccaaga     1800

aggaggagaa gaggaaagat accaaacctg agctcaagaa gatttccaag ccagacctaa     1860

agccctttac tcctgaggta cgtaagaccc tctataaagc caaggtccct ggaagagtca     1920

aaatagacag gagccgtgct atccgtgggg agaaggagct gtcttctgag ccccagacac     1980

ccccagccca gaagggaact gtaccactcc caaccatcag tgggcacagg gagctggtcc     2040

tatcctcacc agaggacctc acacaggact ttgaggagat gaagcgtgag gagagggctt     2100

tgctggctga acaaagggac acaggactag gagataagcc attccctcta gacactgcag     2160

aggagggacc cccaagtaca gctatccagg gaacaccacc ctctgttcca gggctgggac     2220

aagaagaaca tgtgatgaag gagaaagagc ttgtcccaga ggtccctgag gaacaaggca     2280

gcaaggacag aggcctagac tctggggctg aaacagagga agagaaagat acctgggagg     2340

aaaagaagca gagggaagca gagaggctcc cagacagaac agaagccaga gaggaaagtg     2400

aacctgaagt aaaggaggat gtgatagaaa aggctgagtt agaagaaatg gaggaggtac     2460

acccttcaga tgaggaggaa gaggacgcga caaaagctga gggtttttac caaaaacata     2520

tgcaggaacc cttgaaggta actccaagga gccgggaggc ttttgggggt cgggaattgg     2580

gactccaggg caaggcccct gagaaggaga cctcgttatt cctaagcagc ctgaccacac     2640

ctgcaggagc cactgagcat gtctcttaca tccaggatga gacaatccct ggctactcag     2700

agactgagca gaccatctca gatgaggaga tccatgatga gccggaggag cgcccagctc     2760

cacccagatt tcatacaagt acatatgacc tgcccgggcc tgaaggtgct ggcccattcg     2820

aagccagcca acctgccgat agtgctgttc ctgctacctc tggcaaagtc tatggaacgc     2880

cagagactga actcacctac cccactaaca tagtggctgc ccctttggct gaagaggaac     2940

atgtgtcctc ggccacttca atcactgagt gtgacaaact ttcttccttt gccacatcag     3000

tggctgagga ccaatctgtg gcctcactta cagctcccca gacagaggag acaggcaaga     3060

gctccctgct gcttgacaca gtcacaagca tcccttcctc ccgtactgaa gctacgcagg     3120

gcttggacta tgtgccatca gctggtacca tctcacccac ctcctcactg gaagaagaca     3180

agggcttcaa atcaccaccc tgtgaggact tctctgtgac tggggagtca gagaagagag     3240

gagagatcat agggaaaggc ttgtctggag agagagctgt ggaagaggaa gaggaggaga     3300

cagcaaacgt agagatgtct gagaaacttt gcagtcaata tggaactcca gtgtttagtg     3360

cccctgggca tgccctacat ccaggagaac cagcccttgg agaagcagag gagcggtgcc     3420

ttagcccaga tgacagcaca gtgaagatgg cttctcctcc accatctggc ccacccagtg     3480

ccacccacac accctttcat cagtccccag tggaagaaaa gtctgagccc caagactttc     3540

aggaggcaga ctcctgggga gacactaagc gcacaccagg tgtgggcaaa gaagatgctg     3600

ctgaggagac agtcaagcca gggcctgaag agggcacact agagaaggaa gagaaagttc     3660

ctcctcccag gagcccccag gcccaggaag cacctgtcaa cattgatgag gggcttacag     3720

gctgtaccat tcaactgttg ccagcacagg ataaagcaat agtctttgag attatggagg     3780

caggagagcc cacaggccca attctgggag cagaagccct tcccggaggt ttgaggactt     3840

taccccaaga acctggcaaa cctcagaaag atgaggtgct cagatatcct gaccgaagcc     3900

tctctcctga agatgcagaa tccctctctg tcctcagcgt gccctcccca gacactgcca     3960

accaagagcc tacccccaag tctccctgtg gcctgacaga acagtaccta cacaaagacc     4020

gttggccaga ggtatctcca gaagacaccc agtcactttc tctgtcagaa gagagtccca     4080

gcaaggagac ctccctggat gtctcttcta agcagctctc tccagaaagc cttggcaccc     4140

tccagtttgg ggaactaaac cttgggaagg aagaaatggg gcatctgatg caggccgagg     4200

atacctctca ccacacagct cccatgtctg ttccagagcc ccatgcagcc acagcgtcac     4260

ctcccacaga tgggacaact cgatactctg cacagacaga catcacagat gacagccttg     4320

acaggaagtc acctgccagc tcattctctc actctacacc ttcaggaaat gggaagtact     4380

tacctggggc gatcacaagc cctgatgaac acattctgac acctgatagc tccttctcca     4440

agagtcctga gtctttgcca ggccctgcct tggaggacat tgccataaag tgggaagata     4500

aagttccagg gttgaaagac agaacctcag aacagaagaa ggaacctgag ccaaaggatg     4560

aagttttaca gcagaaagac aaaactctgg agcacaagga ggtggtagag ccgaaggata     4620

cagccatcta tcagaaagat gaggctctgc atgtaaagaa tgaggctgtg aaacagcagg     4680

ataaggcttt agaacaaaag ggcagagact tagagcaaaa agacacagcc ctagaacaga     4740

aggacaaggc cctggaacca aaagacaaag acttagaaga aaaagacaag gccctggaac     4800

agaaggataa gattccagaa gagaaagaca aagccttaga acaaaaggat acagccctgg     4860

aacagaagga caaggccctg gaaccaaaag ataaagactt ggaacaaaag gacagggtcc     4920

tagaacagaa ggagaagatc ccagaagaga aagacaaagc cttagatcaa aaagtcagaa     4980

gtgttgaaca taaggctccg gaggacacgg tcgctgaaat gaaggacaga gacctagaac     5040

agacagacaa agcccctgaa cagaaacacc aggcccagga acaaaaggat aaagtctcag     5100

aaaagaagga tcaggcctta gaacaaaaat actgggcttt gggacagaag gatgaagccc     5160

tggaacaaaa cattcaggct ctggaagaga accaccaaac tcaggagcag gagagcctag     5220

tgcaggagga taaaaccagg aaaccaaaga tgctagagga aaaatcccca gaaaaggtca     5280

aggccatgga agagaagtta gaagctcttc tggagaagac caaagctctg ggcctggaag     5340

agagcctagt gcaggagggc agggccagag agcaggaaga aaagtactgg agggggcagg     5400

atgtggtcca ggagtggcaa gaaacatctc ctaccagaga ggagccggct ggagaacaga     5460

aagagcttgc cccggcatgg gaggacacat ctcctgagca ggacaatagg tattggaggg     5520

gcagagagga tgtggccttg gaacaggaca catactggag ggagctaagc tgtgagcgga     5580

aggtctggtt ccctcacgag ctggatggcc agggggcccg cccacactac actgaggaac     5640

gggaaagcac tttcctagat gagggcccag atgatgagca agaagtaccc ctgcgggaac     5700

acgcaacccg gagcccctgg gcctcagact tcaaggattt ccaggaatcc tcaccacaga     5760

aggggctaga ggtggagcgc tggcttgctg aatcaccagt tgggttgcca ccagaggaag     5820

aggacaaact gacccgctct ccctttgaga tcatctcccc tccagcttcc ccacctgaga     5880

tggttggaca aagggttcct tcagccccag gacaagagag tcctatccca gaccctaagc     5940

tcatgccaca catgaagaat gaacccacta ctccctcatg gctggctgac atcccaccct     6000

gggtgcccaa ggacagaccc ctcccccctg cacccctctc cccagctcct ggtcccccca     6060

cacctgcccc ggaatcccat actcctgcac ccttctcttg gggcacagcc gagtatgaca     6120

gtgtggtggc tgcagtgcag gagggggcag ctgagttgga aggtgggcca tactcccccc     6180

tggggaagga ctaccgcaag gctgaagggg aaagggaaga agaaggtagg gctgaggctc     6240

ctgacaaaag ctcacacagc tcaaaggtac cagaggccag caaaagccat gccaccacgg     6300

agcctgagca gactgagccg gagcagagag agcccacacc ctatcctgat gagagaagct     6360

ttcagtatgc agacatctat gagcagatga tgcttactgg gcttggccct gcatgcccca     6420

ctagagagcc tccacttgga gcagctgggg attggccccc atgcctctca accaaggagg     6480

cagctgccgg ccgaaacaca tctgcagaga aggagctttc atctcctatc tcacccaaga     6540

gcctccagtc tgacactcca accttcagct atgcagccct ggcaggaccc actgtacccc     6600

caaggccaga gccagggcca agtatggagc ccagcctcac cccacctgca gttccccccc     6660

gtgctcctat cctgagcaaa ggcccaagcc cccctcttaa tggtaacatc ctgagctgca     6720

gcccagatag gaggtcccca tcccccaagg aatcaggccg gagtcactgg gatgacagca     6780

ctagtgactc agaactggag aagggggctc gggaacagcc agaaaaagag gcccaatccc     6840

caagtcctcc tcaccccatt cctatggggt cccccacatt atggccagaa actgaggcac     6900

atgttagccc tcccttggac tcacacctgg ggcctgcccg acccagtctg gacttccctg     6960

cttcagcctt tggcttctcc tcattgcagc cagctccccc acagctgccc tctccagctg     7020

aaccccgctc ggcaccctgt ggctcccttg ccttctctgg ggatcgagct ctggctctgg     7080

ctccaggacc ccccaccaga acccggcatg atgaatacct ggaagtgacc aaggccccca     7140

gcctggattc ctcactgccc cagctcccat cacccagttc tcctggggcc cctctcctct     7200

ccaatctgcc acgacctgcc tcaccagccc tgtctgaggg ctcctcctct gaggctacca     7260

cgcctgtgat ttcaagtgtg gcggagcgct tctctccaag ccttgaggct gcagaacagg     7320

agtctggaga gctggaccca ggaatggaac cagctgccca cagcctctgg gacctcactc     7380

ctctgagccc agcaccccca gcttcactgg acttggccct agctccagct ccaagcctgc     7440

ctggagacat gggtgatggc atcctgccgt gccacctgga gtgctcagag gcagccacgg     7500

agaagccaag ccccttccag gttccctctg aggattgtgc agccaatggc ccaactgaaa     7560

ccagccctaa ccccccaggc cctgccccag ccaaggctga aaatgaagag gctgcggctt     7620

gccctgcctg ggaacgtggg gcctggcctg aaggagctga gaggagctcc cggcctgaca     7680

cattgctctc ccctgagcag ccagtgtgtc ctgcaggggg ctccgggggc ccacccagca     7740

gtgcctctcc tgaggtcgaa gctgggcccc agggatgtgc cactgagcct cggccccatc     7800

gtggggagct ctccccatcc ttcctgaacc cacctctgcc cccatccata gatgataggg     7860

acctctcaac tgaggaagtt cggctagtag gaagaggggg gcggcgccgg gtaggggggc     7920

cagggaccac tgggggccca tgccctgtga ctgatgagac accccctaca tcagccagtg     7980

actcaggctc ctcacagtca gattctgatg tcccgccaga aactgaggag tgtccgtcca     8040

tcacagctga ggcagccctc gactcagatg aagatggaga cttcctacct gtggacaaag     8100

ctgggggtgt cagtggtact caccacccca ggcctggcca tgacccacct cctctcccac     8160

agccagaccc ccgcccatcc cctccccgcc ctgatgtgtg catggctgac cccgaggggc     8220

tcagctcaga gtctgggaga gtagagaggc tacgggagaa ggaaaaggtt caggggcgag     8280

tagggcgcag ggccccaggc aaggccaagc cagcgtcccc tgcacggcgt ctggatcttc     8340

ggggaaaacg ctcacccacc cctggtaaag ggcctgcaga tcgagcatcc cgggccccac     8400

ctcgaccacg cagcaccaca agccaggtca ccccagcaga ggaaaaggat ggacacagcc     8460

ccatgtccaa aggcctagtc aatggactca aggcaggacc aatggccttg agttccaagg     8520

gcagctctgg tgcccctgta tatgtggatc tcgcctacat cccgaatcat tgcagtggca     8580

agactgctga ccttgacttc ttccgtcgag tgcgtgcatc ctactatgtg gtcagtggga     8640

atgaccctgc caatggcgag ccaagccggg ctgtgctgga tgccctgctg gagggcaagg     8700

cccagtgggg ggagaatctt caggtgactc tgatccctac tcatgacacg gaggtgactc     8760

gtgagtggta ccaacaaact catgagcagc agcaacaact gaatgtcctg gtcctggcta     8820

gcagcagcac cgtggtgatg caggatgagt ccttccctgc ctgcaagatt gagttctgaa     8880

agagccgccc tcccttcccc aaggatccac tcccccagct cctttagaga atggctactg     8940

ctgagtcctt tggggttgag ggagatggga gctaggggga ggggagggag atgtcttgtt     9000

gtggggactt gggctgggct aaatgggagg ggttgtccct ccccatcatc cattcctgtg     9060

aggtgtctca aaccaaagtt aacagggaga ggatggggga ggggacaaat tagaatagga     9120

tagcatctga tgcctgagaa ccctctccta gcactgtcaa atgctggtat tgaatgggga     9180

ctgaggatgg gtctcagaga gcaacctcct ccctcgtaga gggagattat atccccaact     9240

ccagggacct ctttatctca atctatttat ttggcatcct gggagggatt tccaatagta     9300

atttatgtga cctggggcag gataccgtca gtgaggtgcc cagagctgca ccctttcctc     9360

catttcccat cccccatctc ctcaaccacc agggtctgag ttctagcagg gtcctggggg     9420

tatcccactg ctatactgtt ctactgcttc cctcagtatc tgaatgtctc aatttaaaac     9480

ttgaagctct ttagaccaat agactggtga gaggagaaag gagcttatcc cccagaccct     9540

gctttatacc attcacatcc cagggctgtg tccagacagc acaaaacggc aaggagagcc     9600

caagccccaa tgccagaatt cttccaaact ccctgactct ttgaagtttt tactcacccc     9660

atttcaatta tcctgatccc ttctcatccc ctgcttggct tctctgcatg tggtcatctg     9720

ctgtggcttg gtgtttaatg ggttaaaaat aagccactgc ctgacatccc aacatttgac     9780

accccagcaa tgtgtgactc ccccaacatt ccactatgcc atcctgcagc tgaaatggga     9840

acactggctg cctctccaaa cccgctcttg gacagaggat ctgggaggtg gaagccaggc     9900

cagaggactt ggggaaaatg agatggagga aggaaaaagg gagaagctga gccacagctt     9960

aactcctaca gagtgaaatg aaaacgggct gaaaatacca ccccaggaga ggacctcgcc    10020

ccaagcaagc cagtgagcag ccctgccaga ctactgccag actgagaaac ccagaagctg    10080

gtagtcatgt gggcttgcct tctctgccaa acgactggga aaccaaaatg agcccacctt    10140

gtgttcttcc tagctccacc ctccccgtgc tgctgtgttc tgctcctccc cacgcttccc    10200

tgctatagtt cccagctgct gtaacggagc cacctccaac tctaacaata aaccaagttc    10260

attgcagata gtgta                                                     10275


<210>  103
<211>  2803
<212>  PRT
<213>  homo sapiens

<400>  103

Met Asp Gly Val Ala Glu Phe Ser Glu Tyr Val Ser Glu Thr Val Asp 
1               5                   10                  15      


Val Pro Ser Pro Phe Asp Leu Leu Glu Pro Pro Thr Ser Gly Gly Phe 
            20                  25                  30          


Leu Lys Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly 
        35                  40                  45              


Asp Ser Ala Leu Phe Ala Val Asn Gly Phe Asn Ile Leu Val Asp Gly 
    50                  55                  60                  


Gly Ser Asp Arg Lys Ser Cys Phe Trp Lys Leu Val Arg His Leu Asp 
65                  70                  75                  80  


Arg Ile Asp Ser Val Leu Leu Thr His Ile Gly Ala Asp Asn Leu Pro 
                85                  90                  95      


Gly Ile Asn Gly Leu Leu Gln Arg Lys Val Ala Glu Leu Glu Glu Glu 
            100                 105                 110         


Gln Ser Gln Gly Ser Ser Ser Tyr Ser Asp Trp Val Lys Asn Leu Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Val Val Phe Phe Asn Val Pro Glu Lys Leu Arg 
    130                 135                 140                 


Leu Pro Asp Ala Ser Arg Lys Ala Lys Arg Ser Ile Glu Glu Ala Cys 
145                 150                 155                 160 


Leu Thr Leu Gln His Leu Asn Arg Leu Gly Ile Gln Ala Glu Pro Leu 
                165                 170                 175     


Tyr Arg Val Val Ser Asn Thr Ile Glu Pro Leu Thr Leu Phe His Lys 
            180                 185                 190         


Met Gly Val Gly Arg Leu Asp Met Tyr Val Leu Asn Pro Val Lys Asp 
        195                 200                 205             


Ser Lys Glu Met Gln Phe Leu Met Gln Lys Trp Ala Gly Asn Ser Lys 
    210                 215                 220                 


Ala Lys Thr Gly Ile Val Leu Pro Asn Gly Lys Glu Ala Glu Ile Ser 
225                 230                 235                 240 


Val Pro Tyr Leu Thr Ser Ile Thr Ala Leu Val Val Trp Leu Pro Ala 
                245                 250                 255     


Asn Pro Thr Glu Lys Ile Val Arg Val Leu Phe Pro Gly Asn Ala Pro 
            260                 265                 270         


Gln Asn Lys Ile Leu Glu Gly Leu Glu Lys Leu Arg His Leu Asp Phe 
        275                 280                 285             


Leu Arg Tyr Pro Val Ala Thr Gln Lys Asp Leu Ala Ser Gly Ala Val 
    290                 295                 300                 


Pro Thr Asn Leu Lys Pro Ser Lys Ile Lys Gln Arg Ala Asp Ser Lys 
305                 310                 315                 320 


Glu Ser Leu Lys Ala Thr Thr Lys Thr Ala Val Ser Lys Leu Ala Lys 
                325                 330                 335     


Arg Glu Glu Val Val Glu Glu Gly Ala Lys Glu Ala Arg Ser Glu Leu 
            340                 345                 350         


Ala Lys Glu Leu Ala Lys Thr Glu Lys Lys Ala Lys Glu Ser Ser Glu 
        355                 360                 365             


Lys Pro Pro Glu Lys Pro Ala Lys Pro Glu Arg Val Lys Thr Glu Ser 
    370                 375                 380                 


Ser Glu Ala Leu Lys Ala Glu Lys Arg Lys Leu Ile Lys Asp Lys Val 
385                 390                 395                 400 


Gly Lys Lys His Leu Lys Glu Lys Ile Ser Lys Leu Glu Glu Lys Lys 
                405                 410                 415     


Asp Lys Glu Lys Lys Glu Ile Lys Lys Glu Arg Lys Glu Leu Lys Lys 
            420                 425                 430         


Asp Glu Gly Arg Lys Glu Glu Lys Lys Asp Ala Lys Lys Glu Glu Lys 
        435                 440                 445             


Arg Lys Asp Thr Lys Pro Glu Leu Lys Lys Ile Ser Lys Pro Asp Leu 
    450                 455                 460                 


Lys Pro Phe Thr Pro Glu Val Arg Lys Thr Leu Tyr Lys Ala Lys Val 
465                 470                 475                 480 


Pro Gly Arg Val Lys Ile Asp Arg Ser Arg Ala Ile Arg Gly Glu Lys 
                485                 490                 495     


Glu Leu Ser Ser Glu Pro Gln Thr Pro Pro Ala Gln Lys Gly Thr Val 
            500                 505                 510         


Pro Leu Pro Thr Ile Ser Gly His Arg Glu Leu Val Leu Ser Ser Pro 
        515                 520                 525             


Glu Asp Leu Thr Gln Asp Phe Glu Glu Met Lys Arg Glu Glu Arg Ala 
    530                 535                 540                 


Leu Leu Ala Glu Gln Arg Asp Thr Gly Leu Gly Asp Lys Pro Phe Pro 
545                 550                 555                 560 


Leu Asp Thr Ala Glu Glu Gly Pro Pro Ser Thr Ala Ile Gln Gly Thr 
                565                 570                 575     


Pro Pro Ser Val Pro Gly Leu Gly Gln Glu Glu His Val Met Lys Glu 
            580                 585                 590         


Lys Glu Leu Val Pro Glu Val Pro Glu Glu Gln Gly Ser Lys Asp Arg 
        595                 600                 605             


Gly Leu Asp Ser Gly Ala Glu Thr Glu Glu Glu Lys Asp Thr Trp Glu 
    610                 615                 620                 


Glu Lys Lys Gln Arg Glu Ala Glu Arg Leu Pro Asp Arg Thr Glu Ala 
625                 630                 635                 640 


Arg Glu Glu Ser Glu Pro Glu Val Lys Glu Asp Val Ile Glu Lys Ala 
                645                 650                 655     


Glu Leu Glu Glu Met Glu Glu Val His Pro Ser Asp Glu Glu Glu Glu 
            660                 665                 670         


Asp Ala Thr Lys Ala Glu Gly Phe Tyr Gln Lys His Met Gln Glu Pro 
        675                 680                 685             


Leu Lys Val Thr Pro Arg Ser Arg Glu Ala Phe Gly Gly Arg Glu Leu 
    690                 695                 700                 


Gly Leu Gln Gly Lys Ala Pro Glu Lys Glu Thr Ser Leu Phe Leu Ser 
705                 710                 715                 720 


Ser Leu Thr Thr Pro Ala Gly Ala Thr Glu His Val Ser Tyr Ile Gln 
                725                 730                 735     


Asp Glu Thr Ile Pro Gly Tyr Ser Glu Thr Glu Gln Thr Ile Ser Asp 
            740                 745                 750         


Glu Glu Ile His Asp Glu Pro Glu Glu Arg Pro Ala Pro Pro Arg Phe 
        755                 760                 765             


His Thr Ser Thr Tyr Asp Leu Pro Gly Pro Glu Gly Ala Gly Pro Phe 
    770                 775                 780                 


Glu Ala Ser Gln Pro Ala Asp Ser Ala Val Pro Ala Thr Ser Gly Lys 
785                 790                 795                 800 


Val Tyr Gly Thr Pro Glu Thr Glu Leu Thr Tyr Pro Thr Asn Ile Val 
                805                 810                 815     


Ala Ala Pro Leu Ala Glu Glu Glu His Val Ser Ser Ala Thr Ser Ile 
            820                 825                 830         


Thr Glu Cys Asp Lys Leu Ser Ser Phe Ala Thr Ser Val Ala Glu Asp 
        835                 840                 845             


Gln Ser Val Ala Ser Leu Thr Ala Pro Gln Thr Glu Glu Thr Gly Lys 
    850                 855                 860                 


Ser Ser Leu Leu Leu Asp Thr Val Thr Ser Ile Pro Ser Ser Arg Thr 
865                 870                 875                 880 


Glu Ala Thr Gln Gly Leu Asp Tyr Val Pro Ser Ala Gly Thr Ile Ser 
                885                 890                 895     


Pro Thr Ser Ser Leu Glu Glu Asp Lys Gly Phe Lys Ser Pro Pro Cys 
            900                 905                 910         


Glu Asp Phe Ser Val Thr Gly Glu Ser Glu Lys Arg Gly Glu Ile Ile 
        915                 920                 925             


Gly Lys Gly Leu Ser Gly Glu Arg Ala Val Glu Glu Glu Glu Glu Glu 
    930                 935                 940                 


Thr Ala Asn Val Glu Met Ser Glu Lys Leu Cys Ser Gln Tyr Gly Thr 
945                 950                 955                 960 


Pro Val Phe Ser Ala Pro Gly His Ala Leu His Pro Gly Glu Pro Ala 
                965                 970                 975     


Leu Gly Glu Ala Glu Glu Arg Cys Leu Ser Pro Asp Asp Ser Thr Val 
            980                 985                 990         


Lys Met Ala Ser Pro Pro Pro Ser  Gly Pro Pro Ser Ala  Thr His Thr 
        995                 1000                 1005             


Pro Phe  His Gln Ser Pro Val  Glu Glu Lys Ser Glu  Pro Gln Asp 
    1010                 1015                 1020             


Phe Gln  Glu Ala Asp Ser Trp  Gly Asp Thr Lys Arg  Thr Pro Gly 
    1025                 1030                 1035             


Val Gly  Lys Glu Asp Ala Ala  Glu Glu Thr Val Lys  Pro Gly Pro 
    1040                 1045                 1050             


Glu Glu  Gly Thr Leu Glu Lys  Glu Glu Lys Val Pro  Pro Pro Arg 
    1055                 1060                 1065             


Ser Pro  Gln Ala Gln Glu Ala  Pro Val Asn Ile Asp  Glu Gly Leu 
    1070                 1075                 1080             


Thr Gly  Cys Thr Ile Gln Leu  Leu Pro Ala Gln Asp  Lys Ala Ile 
    1085                 1090                 1095             


Val Phe  Glu Ile Met Glu Ala  Gly Glu Pro Thr Gly  Pro Ile Leu 
    1100                 1105                 1110             


Gly Ala  Glu Ala Leu Pro Gly  Gly Leu Arg Thr Leu  Pro Gln Glu 
    1115                 1120                 1125             


Pro Gly  Lys Pro Gln Lys Asp  Glu Val Leu Arg Tyr  Pro Asp Arg 
    1130                 1135                 1140             


Ser Leu  Ser Pro Glu Asp Ala  Glu Ser Leu Ser Val  Leu Ser Val 
    1145                 1150                 1155             


Pro Ser  Pro Asp Thr Ala Asn  Gln Glu Pro Thr Pro  Lys Ser Pro 
    1160                 1165                 1170             


Cys Gly  Leu Thr Glu Gln Tyr  Leu His Lys Asp Arg  Trp Pro Glu 
    1175                 1180                 1185             


Val Ser  Pro Glu Asp Thr Gln  Ser Leu Ser Leu Ser  Glu Glu Ser 
    1190                 1195                 1200             


Pro Ser  Lys Glu Thr Ser Leu  Asp Val Ser Ser Lys  Gln Leu Ser 
    1205                 1210                 1215             


Pro Glu  Ser Leu Gly Thr Leu  Gln Phe Gly Glu Leu  Asn Leu Gly 
    1220                 1225                 1230             


Lys Glu  Glu Met Gly His Leu  Met Gln Ala Glu Asp  Thr Ser His 
    1235                 1240                 1245             


His Thr  Ala Pro Met Ser Val  Pro Glu Pro His Ala  Ala Thr Ala 
    1250                 1255                 1260             


Ser Pro  Pro Thr Asp Gly Thr  Thr Arg Tyr Ser Ala  Gln Thr Asp 
    1265                 1270                 1275             


Ile Thr  Asp Asp Ser Leu Asp  Arg Lys Ser Pro Ala  Ser Ser Phe 
    1280                 1285                 1290             


Ser His  Ser Thr Pro Ser Gly  Asn Gly Lys Tyr Leu  Pro Gly Ala 
    1295                 1300                 1305             


Ile Thr  Ser Pro Asp Glu His  Ile Leu Thr Pro Asp  Ser Ser Phe 
    1310                 1315                 1320             


Ser Lys  Ser Pro Glu Ser Leu  Pro Gly Pro Ala Leu  Glu Asp Ile 
    1325                 1330                 1335             


Ala Ile  Lys Trp Glu Asp Lys  Val Pro Gly Leu Lys  Asp Arg Thr 
    1340                 1345                 1350             


Ser Glu  Gln Lys Lys Glu Pro  Glu Pro Lys Asp Glu  Val Leu Gln 
    1355                 1360                 1365             


Gln Lys  Asp Lys Thr Leu Glu  His Lys Glu Val Val  Glu Pro Lys 
    1370                 1375                 1380             


Asp Thr  Ala Ile Tyr Gln Lys  Asp Glu Ala Leu His  Val Lys Asn 
    1385                 1390                 1395             


Glu Ala  Val Lys Gln Gln Asp  Lys Ala Leu Glu Gln  Lys Gly Arg 
    1400                 1405                 1410             


Asp Leu  Glu Gln Lys Asp Thr  Ala Leu Glu Gln Lys  Asp Lys Ala 
    1415                 1420                 1425             


Leu Glu  Pro Lys Asp Lys Asp  Leu Glu Glu Lys Asp  Lys Ala Leu 
    1430                 1435                 1440             


Glu Gln  Lys Asp Lys Ile Pro  Glu Glu Lys Asp Lys  Ala Leu Glu 
    1445                 1450                 1455             


Gln Lys  Asp Thr Ala Leu Glu  Gln Lys Asp Lys Ala  Leu Glu Pro 
    1460                 1465                 1470             


Lys Asp  Lys Asp Leu Glu Gln  Lys Asp Arg Val Leu  Glu Gln Lys 
    1475                 1480                 1485             


Glu Lys  Ile Pro Glu Glu Lys  Asp Lys Ala Leu Asp  Gln Lys Val 
    1490                 1495                 1500             


Arg Ser  Val Glu His Lys Ala  Pro Glu Asp Thr Val  Ala Glu Met 
    1505                 1510                 1515             


Lys Asp  Arg Asp Leu Glu Gln  Thr Asp Lys Ala Pro  Glu Gln Lys 
    1520                 1525                 1530             


His Gln  Ala Gln Glu Gln Lys  Asp Lys Val Ser Glu  Lys Lys Asp 
    1535                 1540                 1545             


Gln Ala  Leu Glu Gln Lys Tyr  Trp Ala Leu Gly Gln  Lys Asp Glu 
    1550                 1555                 1560             


Ala Leu  Glu Gln Asn Ile Gln  Ala Leu Glu Glu Asn  His Gln Thr 
    1565                 1570                 1575             


Gln Glu  Gln Glu Ser Leu Val  Gln Glu Asp Lys Thr  Arg Lys Pro 
    1580                 1585                 1590             


Lys Met  Leu Glu Glu Lys Ser  Pro Glu Lys Val Lys  Ala Met Glu 
    1595                 1600                 1605             


Glu Lys  Leu Glu Ala Leu Leu  Glu Lys Thr Lys Ala  Leu Gly Leu 
    1610                 1615                 1620             


Glu Glu  Ser Leu Val Gln Glu  Gly Arg Ala Arg Glu  Gln Glu Glu 
    1625                 1630                 1635             


Lys Tyr  Trp Arg Gly Gln Asp  Val Val Gln Glu Trp  Gln Glu Thr 
    1640                 1645                 1650             


Ser Pro  Thr Arg Glu Glu Pro  Ala Gly Glu Gln Lys  Glu Leu Ala 
    1655                 1660                 1665             


Pro Ala  Trp Glu Asp Thr Ser  Pro Glu Gln Asp Asn  Arg Tyr Trp 
    1670                 1675                 1680             


Arg Gly  Arg Glu Asp Val Ala  Leu Glu Gln Asp Thr  Tyr Trp Arg 
    1685                 1690                 1695             


Glu Leu  Ser Cys Glu Arg Lys  Val Trp Phe Pro His  Glu Leu Asp 
    1700                 1705                 1710             


Gly Gln  Gly Ala Arg Pro His  Tyr Thr Glu Glu Arg  Glu Ser Thr 
    1715                 1720                 1725             


Phe Leu  Asp Glu Gly Pro Asp  Asp Glu Gln Glu Val  Pro Leu Arg 
    1730                 1735                 1740             


Glu His  Ala Thr Arg Ser Pro  Trp Ala Ser Asp Phe  Lys Asp Phe 
    1745                 1750                 1755             


Gln Glu  Ser Ser Pro Gln Lys  Gly Leu Glu Val Glu  Arg Trp Leu 
    1760                 1765                 1770             


Ala Glu  Ser Pro Val Gly Leu  Pro Pro Glu Glu Glu  Asp Lys Leu 
    1775                 1780                 1785             


Thr Arg  Ser Pro Phe Glu Ile  Ile Ser Pro Pro Ala  Ser Pro Pro 
    1790                 1795                 1800             


Glu Met  Val Gly Gln Arg Val  Pro Ser Ala Pro Gly  Gln Glu Ser 
    1805                 1810                 1815             


Pro Ile  Pro Asp Pro Lys Leu  Met Pro His Met Lys  Asn Glu Pro 
    1820                 1825                 1830             


Thr Thr  Pro Ser Trp Leu Ala  Asp Ile Pro Pro Trp  Val Pro Lys 
    1835                 1840                 1845             


Asp Arg  Pro Leu Pro Pro Ala  Pro Leu Ser Pro Ala  Pro Gly Pro 
    1850                 1855                 1860             


Pro Thr  Pro Ala Pro Glu Ser  His Thr Pro Ala Pro  Phe Ser Trp 
    1865                 1870                 1875             


Gly Thr  Ala Glu Tyr Asp Ser  Val Val Ala Ala Val  Gln Glu Gly 
    1880                 1885                 1890             


Ala Ala  Glu Leu Glu Gly Gly  Pro Tyr Ser Pro Leu  Gly Lys Asp 
    1895                 1900                 1905             


Tyr Arg  Lys Ala Glu Gly Glu  Arg Glu Glu Glu Gly  Arg Ala Glu 
    1910                 1915                 1920             


Ala Pro  Asp Lys Ser Ser His  Ser Ser Lys Val Pro  Glu Ala Ser 
    1925                 1930                 1935             


Lys Ser  His Ala Thr Thr Glu  Pro Glu Gln Thr Glu  Pro Glu Gln 
    1940                 1945                 1950             


Arg Glu  Pro Thr Pro Tyr Pro  Asp Glu Arg Ser Phe  Gln Tyr Ala 
    1955                 1960                 1965             


Asp Ile  Tyr Glu Gln Met Met  Leu Thr Gly Leu Gly  Pro Ala Cys 
    1970                 1975                 1980             


Pro Thr  Arg Glu Pro Pro Leu  Gly Ala Ala Gly Asp  Trp Pro Pro 
    1985                 1990                 1995             


Cys Leu  Ser Thr Lys Glu Ala  Ala Ala Gly Arg Asn  Thr Ser Ala 
    2000                 2005                 2010             


Glu Lys  Glu Leu Ser Ser Pro  Ile Ser Pro Lys Ser  Leu Gln Ser 
    2015                 2020                 2025             


Asp Thr  Pro Thr Phe Ser Tyr  Ala Ala Leu Ala Gly  Pro Thr Val 
    2030                 2035                 2040             


Pro Pro  Arg Pro Glu Pro Gly  Pro Ser Met Glu Pro  Ser Leu Thr 
    2045                 2050                 2055             


Pro Pro  Ala Val Pro Pro Arg  Ala Pro Ile Leu Ser  Lys Gly Pro 
    2060                 2065                 2070             


Ser Pro  Pro Leu Asn Gly Asn  Ile Leu Ser Cys Ser  Pro Asp Arg 
    2075                 2080                 2085             


Arg Ser  Pro Ser Pro Lys Glu  Ser Gly Arg Ser His  Trp Asp Asp 
    2090                 2095                 2100             


Ser Thr  Ser Asp Ser Glu Leu  Glu Lys Gly Ala Arg  Glu Gln Pro 
    2105                 2110                 2115             


Glu Lys  Glu Ala Gln Ser Pro  Ser Pro Pro His Pro  Ile Pro Met 
    2120                 2125                 2130             


Gly Ser  Pro Thr Leu Trp Pro  Glu Thr Glu Ala His  Val Ser Pro 
    2135                 2140                 2145             


Pro Leu  Asp Ser His Leu Gly  Pro Ala Arg Pro Ser  Leu Asp Phe 
    2150                 2155                 2160             


Pro Ala  Ser Ala Phe Gly Phe  Ser Ser Leu Gln Pro  Ala Pro Pro 
    2165                 2170                 2175             


Gln Leu  Pro Ser Pro Ala Glu  Pro Arg Ser Ala Pro  Cys Gly Ser 
    2180                 2185                 2190             


Leu Ala  Phe Ser Gly Asp Arg  Ala Leu Ala Leu Ala  Pro Gly Pro 
    2195                 2200                 2205             


Pro Thr  Arg Thr Arg His Asp  Glu Tyr Leu Glu Val  Thr Lys Ala 
    2210                 2215                 2220             


Pro Ser  Leu Asp Ser Ser Leu  Pro Gln Leu Pro Ser  Pro Ser Ser 
    2225                 2230                 2235             


Pro Gly  Ala Pro Leu Leu Ser  Asn Leu Pro Arg Pro  Ala Ser Pro 
    2240                 2245                 2250             


Ala Leu  Ser Glu Gly Ser Ser  Ser Glu Ala Thr Thr  Pro Val Ile 
    2255                 2260                 2265             


Ser Ser  Val Ala Glu Arg Phe  Ser Pro Ser Leu Glu  Ala Ala Glu 
    2270                 2275                 2280             


Gln Glu  Ser Gly Glu Leu Asp  Pro Gly Met Glu Pro  Ala Ala His 
    2285                 2290                 2295             


Ser Leu  Trp Asp Leu Thr Pro  Leu Ser Pro Ala Pro  Pro Ala Ser 
    2300                 2305                 2310             


Leu Asp  Leu Ala Leu Ala Pro  Ala Pro Ser Leu Pro  Gly Asp Met 
    2315                 2320                 2325             


Gly Asp  Gly Ile Leu Pro Cys  His Leu Glu Cys Ser  Glu Ala Ala 
    2330                 2335                 2340             


Thr Glu  Lys Pro Ser Pro Phe  Gln Val Pro Ser Glu  Asp Cys Ala 
    2345                 2350                 2355             


Ala Asn  Gly Pro Thr Glu Thr  Ser Pro Asn Pro Pro  Gly Pro Ala 
    2360                 2365                 2370             


Pro Ala  Lys Ala Glu Asn Glu  Glu Ala Ala Ala Cys  Pro Ala Trp 
    2375                 2380                 2385             


Glu Arg  Gly Ala Trp Pro Glu  Gly Ala Glu Arg Ser  Ser Arg Pro 
    2390                 2395                 2400             


Asp Thr  Leu Leu Ser Pro Glu  Gln Pro Val Cys Pro  Ala Gly Gly 
    2405                 2410                 2415             


Ser Gly  Gly Pro Pro Ser Ser  Ala Ser Pro Glu Val  Glu Ala Gly 
    2420                 2425                 2430             


Pro Gln  Gly Cys Ala Thr Glu  Pro Arg Pro His Arg  Gly Glu Leu 
    2435                 2440                 2445             


Ser Pro  Ser Phe Leu Asn Pro  Pro Leu Pro Pro Ser  Ile Asp Asp 
    2450                 2455                 2460             


Arg Asp  Leu Ser Thr Glu Glu  Val Arg Leu Val Gly  Arg Gly Gly 
    2465                 2470                 2475             


Arg Arg  Arg Val Gly Gly Pro  Gly Thr Thr Gly Gly  Pro Cys Pro 
    2480                 2485                 2490             


Val Thr  Asp Glu Thr Pro Pro  Thr Ser Ala Ser Asp  Ser Gly Ser 
    2495                 2500                 2505             


Ser Gln  Ser Asp Ser Asp Val  Pro Pro Glu Thr Glu  Glu Cys Pro 
    2510                 2515                 2520             


Ser Ile  Thr Ala Glu Ala Ala  Leu Asp Ser Asp Glu  Asp Gly Asp 
    2525                 2530                 2535             


Phe Leu  Pro Val Asp Lys Ala  Gly Gly Val Ser Gly  Thr His His 
    2540                 2545                 2550             


Pro Arg  Pro Gly His Asp Pro  Pro Pro Leu Pro Gln  Pro Asp Pro 
    2555                 2560                 2565             


Arg Pro  Ser Pro Pro Arg Pro  Asp Val Cys Met Ala  Asp Pro Glu 
    2570                 2575                 2580             


Gly Leu  Ser Ser Glu Ser Gly  Arg Val Glu Arg Leu  Arg Glu Lys 
    2585                 2590                 2595             


Glu Lys  Val Gln Gly Arg Val  Gly Arg Arg Ala Pro  Gly Lys Ala 
    2600                 2605                 2610             


Lys Pro  Ala Ser Pro Ala Arg  Arg Leu Asp Leu Arg  Gly Lys Arg 
    2615                 2620                 2625             


Ser Pro  Thr Pro Gly Lys Gly  Pro Ala Asp Arg Ala  Ser Arg Ala 
    2630                 2635                 2640             


Pro Pro  Arg Pro Arg Ser Thr  Thr Ser Gln Val Thr  Pro Ala Glu 
    2645                 2650                 2655             


Glu Lys  Asp Gly His Ser Pro  Met Ser Lys Gly Leu  Val Asn Gly 
    2660                 2665                 2670             


Leu Lys  Ala Gly Pro Met Ala  Leu Ser Ser Lys Gly  Ser Ser Gly 
    2675                 2680                 2685             


Ala Pro  Val Tyr Val Asp Leu  Ala Tyr Ile Pro Asn  His Cys Ser 
    2690                 2695                 2700             


Gly Lys  Thr Ala Asp Leu Asp  Phe Phe Arg Arg Val  Arg Ala Ser 
    2705                 2710                 2715             


Tyr Tyr  Val Val Ser Gly Asn  Asp Pro Ala Asn Gly  Glu Pro Ser 
    2720                 2725                 2730             


Arg Ala  Val Leu Asp Ala Leu  Leu Glu Gly Lys Ala  Gln Trp Gly 
    2735                 2740                 2745             


Glu Asn  Leu Gln Val Thr Leu  Ile Pro Thr His Asp  Thr Glu Val 
    2750                 2755                 2760             


Thr Arg  Glu Trp Tyr Gln Gln  Thr His Glu Gln Gln  Gln Gln Leu 
    2765                 2770                 2775             


Asn Val  Leu Val Leu Ala Ser  Ser Ser Thr Val Val  Met Gln Asp 
    2780                 2785                 2790             


Glu Ser  Phe Pro Ala Cys Lys  Ile Glu Phe 
    2795                 2800             


<210>  104
<211>  3866
<212>  DNA
<213>  homo sapiens

<400>  104
agctactcca ccccactctg gctgtagtgt gacattcctg cctgcctgag gaagaaatgg       60

tgagcagggg ctgcaattgc agacaagtgt cacccagaag ccacaagttt ctgtgagcac      120

caggtctaca aactacccaa ggcatagcaa tggcattatc actggaagaa ttcgtccact      180

cccttgacct caggacccta cccagggttc tagaaatcca ggcaggcatc tatcttgaag      240

gctctattta tgaaatgttt ggaaatgaat gctgtttttc aacaggagaa gtgattaaaa      300

ttactggtct caaagttaag aagatcatag ctgaaatttg tgagcagatt gaaggttgtg      360

agtctctaca gccatttgaa ctgcctatga attttccagg tctttttaag attgtggctg      420

ataaaactcc ataccttact atggaagaaa tcacaaggac cattcatatt ggaccaagta      480

gactagggca tccttgcttc tatcatcaga aggatataaa actagagaac ctcatcataa      540

agcagggtga gcaaatcatg ctcaactcag ttgaagagat tgatggagaa ataatggtga      600

gctgtgcagt agcaaggaat catcaaactc actcatttaa tttgcctttg tcacaagaag      660

gagaattcta cgagtgtgaa gatgaacgta tttacactct aaaggagatt gttgaatgga      720

agattcctaa gaacagaaca agaactgtaa accttacaga tttttcaaat aagtgggact      780

caacgaatcc atttcctaaa gacttttatg gtaccctgat tctcaagcct gtttatgaaa      840

ttcaaggtgt gatgaaattt cgaaaagata taatccgcat cctccccagt ctagatgtcg      900

aagtcaaaga catcactgat tcttacgatg ctaactggtt tcttcagctg ttatcaacag      960

aagatctttt tgaaatgact agtaaagagt tccccatagt gactgaagtc atagaagcac     1020

ctgaaggaaa ccacctgccc caaagcattt tacagcctgg gaaaaccatt gtgatccaca     1080

aaaagtacca ggcatcaaga atcttagctt cagaaattag aagcaatttt cctaaaagac     1140

acttcttgat ccccactagc tataaaggca agttcaagcg gcgaccgagg gagttcccaa     1200

cggcctatga cctagagatc gctaagagtg aaaaggagcc tcttcacgtg gtggccacca     1260

aagcgtttca ttcccctcat gacaagctgt catccgtatc tgttggggac cagtttctgg     1320

tgcatcagtc agagacgact gaagtcctct gtgagggaat aaaaaaagtg gtgaatgttc     1380

tggcctgtga aaaaatcctc aaaaagtcct atgaggctgc gctgctccct ttgtacatgg     1440

aaggaggttt tgtagaggtg attcatgata agaaacagta cccgatttct gagctctgta     1500

aacagttccg tttgcccttc aatgtgaagg tgtctgtcag ggatctttcc attgaagagg     1560

acgtgttggc tgccacacca ggactgcagt tggaggagga cattacagac tcttacctac     1620

tcataagtga ctttgccaac cccacggagt gctgggaaat tcctgtgggc cgcttgaata     1680

tgactgttca gttagttagt aatttctcta gggatgcaga accatttcta gtcaggactc     1740

tggtagaaga gatcactgaa gagcaatatt acatgatgcg gagatatgaa agctcagcct     1800

cacatccccc acctcgccct ccgaaacacc cctcagtaga ggaaacaaag ttaaccctgc     1860

taaccttagc agaagaaagg acggtagacc tgcccaagtc tcccaagcgt catcacgtag     1920

acataaccaa gaaacttcac ccaaatcaag ctggcctgga ttcaaaagta ctgattggta     1980

gtcagaatga tttggtggat gaagagaaag aaaggagcaa ccgtggggcc acagcaatag     2040

cagaaacatt caaaaatgaa aaacatcaaa aataacaaga tgtgacagaa gccacttagg     2100

cagcaaacat aaatgttgca gtgaaaaaag aagctagcct tctagctgaa aaacgagtat     2160

tccccaatgg actccagaag aaacttgatt catcgctgca aaggaaagaa caaccttaaa     2220

acttttaaca gataaaactt acagaaacct atgatataga attcatatag tctattctgt     2280

tgtgtctaaa tctgtaggca ttgtgttgtt gttctttagg acgtatttat ttaacttgca     2340

cattttttca gattcttatt tctactacca acaactaagt aattgggaaa taattctgta     2400

tttcagtttc tgagtaaaac cagtctgaaa taggataaaa gccaccaaat attttctttt     2460

ttttccagaa tttgttttgc cattttttag tgctatcatc attcctaaca agactaactt     2520

acagaaaaat aattatatct gactgattta aaatgttcag gtttcttatc caaatccctt     2580

ggaactatgg aaaggagttt gatttcacat tcacagtgta tttacaaaat acgctgtgtc     2640

ataaatatgt ttgaattcca acagccaaag ccattgagag tcataggagt tttccataac     2700

cttctcttct atgacccaac aacaagctca tgactgaaat ttcaccagat ttctgagacg     2760

atgtcttaat attctatgtg ctatgtacca gataattctt tagatgaatg tttcttagga     2820

ttgtaggaaa attatctagt taatcataat atttgatgga aagaaaaaga caataaaatt     2880

gtaatataat aaatttggct gacaagaaac caaagtgatt cttaattagt atacatcaga     2940

atgatgctct tatagttgta ccatctataa aaattacttt aagggctctc acattttaat     3000

aatttatctt attatgtatt aagtatacag gaacaatatt atttttcctt taacaaaatg     3060

aagagacagg ctatctggtt aatgttacat aggaatttaa tagtaatgct tgaacttcat     3120

ccatagatca tactctgtac aaaatttgtt agctaacatc ctatctcata attattttat     3180

gttttgtgga gaaatttgtt gattttgtac caaagtgttt ctgaagacaa taaattgtga     3240

gtcaacttta gaacaaaaaa aattagagtt ttttcaatgt ttatattctg attaagctta     3300

ctttacctta cattttttct aagtaacaat gaatcctgat ttctagtgtc ctaaaaattg     3360

cttagtgatt tgattgtggt aatatcattt cttatctaca atgtctaaag ttttatggga     3420

cagtttttct tttatttatt ttgcctgttt gtgcagataa gaacagaaac ttttctaaga     3480

cccacatttg gttattgaag gccacagcga atcttaacct aacagccttg acaaactgca     3540

ccataggtgt ttttagactc atataatttg ttatttttca aacaatagtg aataattaat     3600

atttttgttt ggaatttgag aacaattaaa tttgtacttt tagtaactac cattctttga     3660

ttagaaaatt aagagaatgc atatcttact ttggttgtaa attatcaagg gctttctaat     3720

agaaatcata tataacattt ctaaatataa gtcctttcac atactgtgtt tccagttgtc     3780

ttgatattga aaagtgtaat aaacttcatg ctcacctatt ggagatttgg gaaggttgaa     3840

aataaacttc ctaattttta tttgta                                          3866


<210>  105
<211>  641
<212>  PRT
<213>  homo sapiens

<400>  105

Met Ala Leu Ser Leu Glu Glu Phe Val His Ser Leu Asp Leu Arg Thr 
1               5                   10                  15      


Leu Pro Arg Val Leu Glu Ile Gln Ala Gly Ile Tyr Leu Glu Gly Ser 
            20                  25                  30          


Ile Tyr Glu Met Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu Val 
        35                  40                  45              


Ile Lys Ile Thr Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile Cys 
    50                  55                  60                  


Glu Gln Ile Glu Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro Met 
65                  70                  75                  80  


Asn Phe Pro Gly Leu Phe Lys Ile Val Ala Asp Lys Thr Pro Tyr Leu 
                85                  90                  95      


Thr Met Glu Glu Ile Thr Arg Thr Ile His Ile Gly Pro Ser Arg Leu 
            100                 105                 110         


Gly His Pro Cys Phe Tyr His Gln Lys Asp Ile Lys Leu Glu Asn Leu 
        115                 120                 125             


Ile Ile Lys Gln Gly Glu Gln Ile Met Leu Asn Ser Val Glu Glu Ile 
    130                 135                 140                 


Asp Gly Glu Ile Met Val Ser Cys Ala Val Ala Arg Asn His Gln Thr 
145                 150                 155                 160 


His Ser Phe Asn Leu Pro Leu Ser Gln Glu Gly Glu Phe Tyr Glu Cys 
                165                 170                 175     


Glu Asp Glu Arg Ile Tyr Thr Leu Lys Glu Ile Val Glu Trp Lys Ile 
            180                 185                 190         


Pro Lys Asn Arg Thr Arg Thr Val Asn Leu Thr Asp Phe Ser Asn Lys 
        195                 200                 205             


Trp Asp Ser Thr Asn Pro Phe Pro Lys Asp Phe Tyr Gly Thr Leu Ile 
    210                 215                 220                 


Leu Lys Pro Val Tyr Glu Ile Gln Gly Val Met Lys Phe Arg Lys Asp 
225                 230                 235                 240 


Ile Ile Arg Ile Leu Pro Ser Leu Asp Val Glu Val Lys Asp Ile Thr 
                245                 250                 255     


Asp Ser Tyr Asp Ala Asn Trp Phe Leu Gln Leu Leu Ser Thr Glu Asp 
            260                 265                 270         


Leu Phe Glu Met Thr Ser Lys Glu Phe Pro Ile Val Thr Glu Val Ile 
        275                 280                 285             


Glu Ala Pro Glu Gly Asn His Leu Pro Gln Ser Ile Leu Gln Pro Gly 
    290                 295                 300                 


Lys Thr Ile Val Ile His Lys Lys Tyr Gln Ala Ser Arg Ile Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Ser Asn Phe Pro Lys Arg His Phe Leu Ile Pro Thr 
                325                 330                 335     


Ser Tyr Lys Gly Lys Phe Lys Arg Arg Pro Arg Glu Phe Pro Thr Ala 
            340                 345                 350         


Tyr Asp Leu Glu Ile Ala Lys Ser Glu Lys Glu Pro Leu His Val Val 
        355                 360                 365             


Ala Thr Lys Ala Phe His Ser Pro His Asp Lys Leu Ser Ser Val Ser 
    370                 375                 380                 


Val Gly Asp Gln Phe Leu Val His Gln Ser Glu Thr Thr Glu Val Leu 
385                 390                 395                 400 


Cys Glu Gly Ile Lys Lys Val Val Asn Val Leu Ala Cys Glu Lys Ile 
                405                 410                 415     


Leu Lys Lys Ser Tyr Glu Ala Ala Leu Leu Pro Leu Tyr Met Glu Gly 
            420                 425                 430         


Gly Phe Val Glu Val Ile His Asp Lys Lys Gln Tyr Pro Ile Ser Glu 
        435                 440                 445             


Leu Cys Lys Gln Phe Arg Leu Pro Phe Asn Val Lys Val Ser Val Arg 
    450                 455                 460                 


Asp Leu Ser Ile Glu Glu Asp Val Leu Ala Ala Thr Pro Gly Leu Gln 
465                 470                 475                 480 


Leu Glu Glu Asp Ile Thr Asp Ser Tyr Leu Leu Ile Ser Asp Phe Ala 
                485                 490                 495     


Asn Pro Thr Glu Cys Trp Glu Ile Pro Val Gly Arg Leu Asn Met Thr 
            500                 505                 510         


Val Gln Leu Val Ser Asn Phe Ser Arg Asp Ala Glu Pro Phe Leu Val 
        515                 520                 525             


Arg Thr Leu Val Glu Glu Ile Thr Glu Glu Gln Tyr Tyr Met Met Arg 
    530                 535                 540                 


Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro Arg Pro Pro Lys His 
545                 550                 555                 560 


Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu Thr Leu Ala Glu Glu 
                565                 570                 575     


Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Arg His His Val Asp Ile 
            580                 585                 590         


Thr Lys Lys Leu His Pro Asn Gln Ala Gly Leu Asp Ser Lys Val Leu 
        595                 600                 605             


Ile Gly Ser Gln Asn Asp Leu Val Asp Glu Glu Lys Glu Arg Ser Asn 
    610                 615                 620                 


Arg Gly Ala Thr Ala Ile Ala Glu Thr Phe Lys Asn Glu Lys His Gln 
625                 630                 635                 640 


Lys 
    


<210>  106
<211>  2668
<212>  DNA
<213>  homo sapiens

<400>  106
ctctctggat aggaagaaat atagtagaac cctttgaaaa tggatatttt cacatatttt       60

cgttcagata caaaagctgg cagttactga aataaggact tgaagttcct tcctcttttt      120

tttatgtctt aagagcagga aataaagaga cagctgaagg tgtagccttg accaactgaa      180

agggaaatct tcatcctctg aaaaaacata tgtgattctc aaaaaacgca tctggaaaat      240

tgataaagaa gcgattctgt agattctccc agcgctgttg ggctctcaat tccttctgtg      300

aaggacaaca tatggtgatg gggaaatcag aagctttgag accctctaca cctggatatg      360

aatccccctt ctaatactta ccagaaatga aggggatact cagggcagag ttctgaatct      420

caaaacactc tactctggca aaggaatgaa gttattggag tgatgacagg aacacgggag      480

aacaatgctc tgtttgggct ggatatttct ttggcttgtt gcaggagagc gaattaaagg      540

atttaatatt tcaggttgtt ccacaaaaaa actcctttgg acatattcta caaggagtga      600

agaggaattt gtcttatttt gtgatttacc agagccacag aaatcacatt tctgccacag      660

aaatcgactc tcaccaaaac aagtccctga gcacctgccc ttcatgggta gtaacgacct      720

atctgatgtc caatggtacc aacaaccttc gaatggagat ccattagagg acattaggaa      780

aagctatcct cacatcattc aggacaaatg tacccttcac tttttgaccc caggggtgaa      840

taattctggg tcatatattt gtagacccaa gatgattaag agcccctatg atgtagcctg      900

ttgtgtcaag atgattttag aagttaagcc ccagacaaat gcatcctgtg agtattccgc      960

atcacataag caagacctac ttcttgggag cactggctct atttcttgcc ccagtctcag     1020

ctgccaaagt gatgcacaaa gtccagcggt aacctggtac aagaatggaa aactcctctc     1080

tgtggaaagg agcaaccgaa tcgtagtgga tgaagtttat gactatcacc agggcacata     1140

tgtatgtgat tacactcagt cggatactgt gagttcgtgg acagtcagag ctgttgttca     1200

agtgagaacc attgtgggag acactaaact caaaccagat attctggatc ctgtcgagga     1260

cacactggaa gtagaacttg gaaagccttt aactattagc tgcaaagcac gatttggctt     1320

tgaaagggtc tttaaccctg tcataaaatg gtacatcaaa gattctgacc tagagtggga     1380

agtctcagta cctgaggcga aaagtattaa atccacttta aaggatgaaa tcattgagcg     1440

taatatcatc ttggaaaaag tcactcagcg tgatcttcgc aggaagtttg tttgctttgt     1500

ccagaactcc attggaaaca caacccagtc cgtccaactg aaagaaaaga gaggagtggt     1560

gctcctgtac atcctgcttg gcaccatcgg gaccctggtg gccgtgctgg cggcgagtgc     1620

cctcctctac aggcactgga ttgaaatagt gctgctgtac cggacctacc agagcaagga     1680

tcagacgctt ggggataaaa aggattttga tgctttcgta tcctatgcaa aatggagctc     1740

ttttccaagt gaggccactt catctctgag tgaagaacac ttggccctga gcctatttcc     1800

tgatgtttta gaaaacaaat atggatatag cctgtgtttg cttgaaagag atgtggctcc     1860

aggaggagtg tatgcagaag acattgtgag cattattaag agaagcagaa gaggaatatt     1920

tatcttgagc cccaactatg tcaatggacc cagtatcttt gaactacaag cagcagtgaa     1980

tcttgccttg gatgatcaaa cactgaaact cattttaatt aagttctgtt acttccaaga     2040

gccagagtct ctacctcatc tcgtgaaaaa agctctcagg gttttgccca cagttacttg     2100

gagaggctta aaatcagttc ctcccaattc taggttctgg gccaaaatgc gctaccacat     2160

gcctgtgaaa aactctcagg gattcacgtg gaaccagctc agaattacct ctaggatttt     2220

tcagtggaaa ggactcagta gaacagaaac cactgggagg agctcccagc ctaaggaatg     2280

gtgaaatgag ccctggagcc ccctccagtc cagtccctgg gatagagatg ttgctggaca     2340

gaactcacag ctctgtgtgt gtgtgttcag gctgatagga aattcaaaga gtctcctgcc     2400

agcaccaagc aagcttgatg gacaatggag tgggattgag actgtggttt agagcctttg     2460

atttcctgga ctggactgac ggcgagtgaa ttctctagac cttgggtact ttcagtacac     2520

aacaccccta agatttccca gtggtccgag cagaatcaga aaatacagct acttctgcct     2580

tatggctagg gaactgtcat gtctaccatg tattgtacat atgactttat gtatacttgc     2640

aatcaaataa atattatttt attagaaa                                        2668


<210>  107
<211>  599
<212>  PRT
<213>  homo sapiens

<400>  107

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  108
<211>  3447
<212>  DNA
<213>  homo sapiens

<400>  108
actcgaagtg cggcgggaga ggcgggagcc caggagaggg tgcgggagct ggcggggcgg       60

ctcggagctg ccaggacgcc ctggtcccag ccgcgcacag gggagcgtgg acggcagagg      120

ggctcggcgg gagccgagat ccgcccgtcc cggctgcccc tcggcctccc tctgctccca      180

cctaccccct gacacccata gaaaagcgtg caaaggcgcg gagcgggacg gaaaccacaa      240

ataaatagcg gcggcggcag cgcgtcatct ggtggagcag gaagtgcagg cagagtccgg      300

aggctggtgc tttctgcgcg tccccaggac tttgccatgg gctgggggcc gcggaggctg      360

cgagcggccg ggcgagggca gcggcggcgg cgtccgcacc ggggctgagc gagcagcgac      420

gcgaggggcg cgcggagatg gcagcgtcca gcaactccag cctgtccggc tcgtcggtgt      480

cctccgatgc tgaagaatac cagcctccta tatggaaatc atacttatat cagttacagc      540

aagaggcacc tcgtcccaag agaatcattt gtcctcggga ggtggaaaac agaccaaaat      600

attatggaag agagtttcat gggatcatct ctcgggagca ggcggatgag cttcttggag      660

gcgtggaggg tgcctacatc cttagagaaa gccagcggca accaggatgc tacacgctgg      720

ctctcaggtt tggaaaccag accttaaact acaggctctt ccacgacggg aaacactttg      780

tgggtgagaa gaggtttgag tcgattcatg atctggtgac agatggcttg ataacactgt      840

acatagaaac aaaagctgcc gagtacattt caaaaatgac aactaacccc atctatgaac      900

acattggata tgccacccta ctcagagaaa aagtatccag aaggctgagc aggtctaaaa      960

atgaaccaag aaaaacaaac gtcacacatg aagaacacac agcggtggaa aagatctcct     1020

ccctggttcg aagggctgcc ctcacacaca acgacaacca cttcaattat gagaagacac     1080

acaactttaa ggtccacacg ttccgaggcc cacactggtg tgaatattgt gccaatttca     1140

tgtgggggct catcgcccaa ggggtccggt gctcagactg tggattgaac gtacacaaac     1200

agtgttccaa gcacgttccc aatgactgcc aacctgatct caagaggatc aagaaagtgt     1260

actgttgtga cctcacaaca cttgtgaagg ctcacaacac tcagagaccc atggtggtag     1320

acatatgcat tcgggaaatt gaagcaagag gattaaaatc ggaaggcctt tacagagtct     1380

ctgggttcac tgaacacatt gaagatgtca aaatggcatt tgacagagat ggtgaaaagg     1440

ccgatatatc tgccaatgtc tatccagaca taaacatcat cactggagcc cttaaactgt     1500

atttcagaga cttacccatc cctgtcatca catatgatac ctattccaaa tttatagatg     1560

cagcaaaaat ctccaatgca gatgagaggc tggaagccgt ccatgaagtg ctgatgctgc     1620

tgcctcctgc ccactatgaa accctccggt acctaatgat ccacctcaaa aaggttacta     1680

tgaatgaaaa agacaatttc atgaatgcag aaaatctggg gatcgtgttt gggcccactc     1740

tgatgaggcc ccctgaggac agcaccctga ccaccctgca tgatatgcgg taccaaaagc     1800

tgattgtgca gattttaata gaaaacgaag acgttttatt ctaatccatc agggaaatga     1860

gctgaatggc cccagcacca tccaagttga cacagctaaa ggaataaaaa catttcttac     1920

cacttgattt gttttccaag caagtgctag aatttgctgg actgcagagg atcgctgagt     1980

ggggtactgt gtctcataga catgcgccac ctccacgtga gaacaagggt gaaggtgagg     2040

gaagcccctc accttgggtc ttttgctgtg cctcctatgt atgtctggtt tgctggaaga     2100

gtgattaata catctttaat ttattaaaaa acaatgtaga cctttaaact tcagtcttat     2160

tggtaataaa agggaactta attcatacag gtacttgata cagttataca ttttccactt     2220

acaaaaagaa gacaattctg ttaaatgaaa cgtgtatcgt aaaatgtatt tttattttac     2280

ccacgagaat gttgttattt ttagcaaata gaactcaatg cagtgcattg gttattaccc     2340

tgtgtacctt gtccctcatt ttgctgtgac accctgaaaa agctgaccac aaatgcagta     2400

ttatcttgac atacctctgt cctcctcagt gctttttaat gaaatttcac ctgccccttg     2460

tgttcctgct ttggatagtt tttgctctta agcattggca ttcttctatt gtatggtatg     2520

tatttatagc aattgtagga tggtctgaaa tgtccacaca ctttctatgc atacaaattt     2580

tgtgaattcc caaagtatgc tttggaattg gtcatagtct tttcgtatca tgagtgtgta     2640

tcccagaaga tacagaatgc ggtcatttta cctgaaatta tttgagaaca ctggatgtat     2700

ctggtctgtg taaaaagtta gcacttaccc tcttttcttc ctggccaagc cctctgaatt     2760

catctgttaa tatcaaattg tatttttgcc acatttctgt attggtgaaa agcgaatctg     2820

cagaataact gtcaacgttt ttcattcttg ttttacaaac ctatttttta aagtgagaat     2880

aaggttggtt tttaccaaat atttgttcct ccttgacaaa agtagctctg tgtggataat     2940

atgattttat tactacagtt ccagtcactt ggttatattt atcttagcat gagcctttca     3000

caccaagatt tctatatttt gtaacatagg tgaaatattt aaaacatcaa aaactgtaaa     3060

tctagatttt taaaaaatcc aactgcaatg tcttttcctt tgattgagat gatttgtgta     3120

aactcaccag tcttgctttg gagtgagcag aagagaatga ctattttacg tggagcatca     3180

ttgtgtgact gttgacctgg acagtcccaa gggctatgca gatggactcc attggcacag     3240

ggaggtttga cctcttccct gctattatcc ctcctcccaa ctgtacagat ttgtttgttg     3300

tagtttatgt acttcttgat actgtcaaaa aattatctgg aaatggtttt attttgtgaa     3360

gtgaacaata ctttgtaatt tatgatagtg taaatggaag gcaaagcatc acatgtatta     3420

aattcttctg tctattaaaa aaaaaaa                                         3447


<210>  109
<211>  468
<212>  PRT
<213>  homo sapiens

<400>  109

Met Ala Ala Ser Ser Asn Ser Ser Leu Ser Gly Ser Ser Val Ser Ser 
1               5                   10                  15      


Asp Ala Glu Glu Tyr Gln Pro Pro Ile Trp Lys Ser Tyr Leu Tyr Gln 
            20                  25                  30          


Leu Gln Gln Glu Ala Pro Arg Pro Lys Arg Ile Ile Cys Pro Arg Glu 
        35                  40                  45              


Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg Glu Phe His Gly Ile Ile 
    50                  55                  60                  


Ser Arg Glu Gln Ala Asp Glu Leu Leu Gly Gly Val Glu Gly Ala Tyr 
65                  70                  75                  80  


Ile Leu Arg Glu Ser Gln Arg Gln Pro Gly Cys Tyr Thr Leu Ala Leu 
                85                  90                  95      


Arg Phe Gly Asn Gln Thr Leu Asn Tyr Arg Leu Phe His Asp Gly Lys 
            100                 105                 110         


His Phe Val Gly Glu Lys Arg Phe Glu Ser Ile His Asp Leu Val Thr 
        115                 120                 125             


Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr Lys Ala Ala Glu Tyr Ile 
    130                 135                 140                 


Ser Lys Met Thr Thr Asn Pro Ile Tyr Glu His Ile Gly Tyr Ala Thr 
145                 150                 155                 160 


Leu Leu Arg Glu Lys Val Ser Arg Arg Leu Ser Arg Ser Lys Asn Glu 
                165                 170                 175     


Pro Arg Lys Thr Asn Val Thr His Glu Glu His Thr Ala Val Glu Lys 
            180                 185                 190         


Ile Ser Ser Leu Val Arg Arg Ala Ala Leu Thr His Asn Asp Asn His 
        195                 200                 205             


Phe Asn Tyr Glu Lys Thr His Asn Phe Lys Val His Thr Phe Arg Gly 
    210                 215                 220                 


Pro His Trp Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala 
225                 230                 235                 240 


Gln Gly Val Arg Cys Ser Asp Cys Gly Leu Asn Val His Lys Gln Cys 
                245                 250                 255     


Ser Lys His Val Pro Asn Asp Cys Gln Pro Asp Leu Lys Arg Ile Lys 
            260                 265                 270         


Lys Val Tyr Cys Cys Asp Leu Thr Thr Leu Val Lys Ala His Asn Thr 
        275                 280                 285             


Gln Arg Pro Met Val Val Asp Ile Cys Ile Arg Glu Ile Glu Ala Arg 
    290                 295                 300                 


Gly Leu Lys Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Thr Glu His 
305                 310                 315                 320 


Ile Glu Asp Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp 
                325                 330                 335     


Ile Ser Ala Asn Val Tyr Pro Asp Ile Asn Ile Ile Thr Gly Ala Leu 
            340                 345                 350         


Lys Leu Tyr Phe Arg Asp Leu Pro Ile Pro Val Ile Thr Tyr Asp Thr 
        355                 360                 365             


Tyr Ser Lys Phe Ile Asp Ala Ala Lys Ile Ser Asn Ala Asp Glu Arg 
    370                 375                 380                 


Leu Glu Ala Val His Glu Val Leu Met Leu Leu Pro Pro Ala His Tyr 
385                 390                 395                 400 


Glu Thr Leu Arg Tyr Leu Met Ile His Leu Lys Lys Val Thr Met Asn 
                405                 410                 415     


Glu Lys Asp Asn Phe Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly 
            420                 425                 430         


Pro Thr Leu Met Arg Pro Pro Glu Asp Ser Thr Leu Thr Thr Leu His 
        435                 440                 445             


Asp Met Arg Tyr Gln Lys Leu Ile Val Gln Ile Leu Ile Glu Asn Glu 
    450                 455                 460                 


Asp Val Leu Phe 
465             


<210>  110
<211>  6540
<212>  DNA
<213>  homo sapiens

<400>  110
tgctgatcgc tcgtgccggt gcggccgtta accgcccttg ccggagccct aggctcaaaa       60

gcagcccctt acccttcctg ggcttccccc aacccctttc ccggtctgcc ctggggcatg      120

agcagcgatg gccggctgca tccctgagga gaaaacttac cggcgcttcc tggagctatt      180

cctgggcgag tttcgcggac cgtgcggcgg cggcgagccg gagccggaac ccgaacccga      240

acccgaaccc gaacccgagt ccgagcccga gcccgaacct gaactggtag aagctgaggc      300

ggccgaggct tcggtagagg aacccgggga ggaggcggcc acggtagccg cgacggagga      360

gggggaccag gagcaagacc cggagcccga ggaggaggcg gcggttgagg gtgaggagga      420

ggaggagggc gcggcgacgg cggcggcagc cccggggcac tcggccgtgc cgccgccgcc      480

gccccagctg ccgcctttgc ccccgctccc gcgaccgctg tcagagcgca tcacccgcga      540

ggaggtggag ggcgaaagcc tggacctgtg cctgcagcag ctctacaaat ataattgccc      600

ttcctttttg gctgctgctt tagccagagc cacatcagat gaagtccttc agagtgatct      660

ttctgcacat tatatcccaa aggaaacgga tggcacagaa gggactgtgg agattgagac      720

agtgaaattg gcccgttctg tcttcagcaa actacacgag atttgctgca gctgggtgaa      780

agacttcccc ctccgcagga gaccccagct ttattatgag acatcaatcc atgccatcaa      840

aaacatgcgc aggaaaatgg aggacaaaca tgtctgcatt cctgacttta atatgctctt      900

caacctagag gaccaggaag aacaagctta ctttgcagtg tttgatggcc atgggggagt      960

agatgctgct atttatgcct ccattcacct ccacgttaac ttagtccgcc aggagatgtt     1020

cccccatgat cctgctgagg ccctgtgcag ggccttccgg gtcactgatg agcggtttgt     1080

gcagaaagca gccagggaga gcttaagatg tgggaccaca ggagtggtga ctttcatcag     1140

aggcaacatg ctacatgtgg cctgggtggg tgattcccag gttatgcttg tgagaaaggg     1200

ccaagctgtt gaactaatga agccacacaa accagacaga gaggatgaaa agcagagaat     1260

tgaggccctt ggaggttgcg tagtctggtt tggtgcctgg agggtgaatg gaagtctgtc     1320

ggtttccaga gctattggag atgctgaaca taagccatat atctgtgggg atgcagattc     1380

tgcctccact gttctggatg ggaccgaaga ctacctcatt ctggcctgtg atggcttcta     1440

tgacaccgtg aaccctgatg aggcagtgaa agttgtgtcc gaccacctga aagagaataa     1500

tggagacagc agcatggttg cccacaaatt agtggcatca gctcgtgatg ctgggtcaag     1560

tgataacatc acggttattg tggtattcct gagggacatg aacaaagctg taaatgttag     1620

tgaggaatca gattggacag agaactcttt tcaaggaggg caagaagatg gtggggatga     1680

taaggagaat catggagagt gcaaacgccc ttggcctcag caccagtgct cagcaccagc     1740

cgacctaggc tatgatgggc gtgtggattc attcactgat agaactagcc tgagcccagg     1800

gtcccaaatc aacgtgctgg aagacccagg ctacctagat ctcacacaaa tagaagcaag     1860

caaacctcac agtgcccagt ttttgctacc agttgagatg tttggtcctg gtgcaccaaa     1920

gaaagcaaat cttattaatg agttaatgat ggagaaaaaa tcagttcagt catcattgcc     1980

tgaatggagt ggtgctggag agtttcccac tgctttcaat ttgggttcaa caggggagca     2040

gatatacaga atgcagagct tgtctcctgt ctgttcaggg ttggaaaatg aacagttcaa     2100

atccccggga aacagagttt ctagattgtc tcatttacgc caccactact caaagaagtg     2160

gcacagattc aggtttaatc caaagtttta ttcatttctc tctgctcaag agccttccca     2220

caaaataggc actagcctgt cctcacttac tggaagtggg aagagaaata ggataagaag     2280

ttctctgcca tggaggcaaa atagttggaa agggtacagt gaaaacatga ggaagctcag     2340

aaagactcat gatattccat gcccagatct tccttggagc tataaaatag aataattttt     2400

ctttcaagta ggttagctag ctctccccca ataaaaatac cactatcaga gtagaaacaa     2460

ggtagacatt tctaaaacat atgtgcttca ttatgaatcc atggatggct caattcttaa     2520

atgtaaatag atctctagga aactcaaagt acagtgtttt caatctaaaa agaagtattg     2580

gcagtttcac ttgcaaaatt acacagctgg tccctgtgat gtgtctcgac accaatacac     2640

aacccccttc ccaccatcct tcatgtcact agatacacaa cccccttccc accatccctt     2700

cagtcactag tggaagcttt caagttagtt atttcagtca ggatatacag tgttgaaatc     2760

tcaatgcagt tgaaatctgg tctgatgtgc ctaatttatc tgtggaaaat ttaatgctga     2820

attacatttg gttgggaaat gtccctcaaa atcctgggca ctatgaagga accccctgcc     2880

ccctcacctt tttgggtagg taaaagacta aaagccatat ggattttaac tgataacaat     2940

gaaagtggta aatcagtgta aaagtgtcat attctcagac ttgtgaggcg gtttatagtc     3000

agaaagattt acggattttt ttcctgtaac ataaaagatt gtgaactttt tttaattaaa     3060

aaatatttcc tagggctgta gttatttggg agtttcataa cctgttatgg tgcttttggt     3120

ggaaattttt attatttagc attttaggag accgctgtca actggtttta atctatgatg     3180

ctaatgtgtt ttccactgta ccctcatctc aggaataaaa ctgctttaac ggagatgatg     3240

tcaggtacaa atacactata gagtcaaaat accatttaca aagaaaatca aaagcatttc     3300

tatattttgt ctttttttag ttcagacagc aaaggcatgt actactataa aatacaaagt     3360

gattttagag aatgaaaaat gctactttta tcttctctaa aattatttcc cccaaggtag     3420

tgaagtaatt ggaatgaagg aggctgaaag tattgtctaa agtgagccca gaggccactg     3480

agaatgcaga ttactgacag ccaggtctgt ttagttgtaa ttggaagaca catgagtgtc     3540

ctgcttacat gtagcttcag actgcagaga caggacgtgt gcttttcatt tcaatattta     3600

gttatatttg atattttgaa actgtctgct ttttgctatt tctgcagttt caagttagtt     3660

agaagcatgt tgtcaactaa agacaacaaa ctatcagatt cattcattca gtgaagcagc     3720

ctctgattct ctaagagtca cgaatgtctt agtgttaccc tcccctagtc aacagcagac     3780

cagcctggcc aatgcctatg ggtggcccct ctggagtgct cactaacaag ggtgagtgct     3840

ctcgctaaga agtgtccccc gcctaatcat gtgtttatag gatagtacac gttccccagg     3900

cccataacag aggactaaaa tctctgaatt ttaaagacac agatgactgg catattttgg     3960

ataccagtat agctatatca aatagacaaa aacagcttca ctttagcaat gatcagattg     4020

ttaatctaca gattttattt tttaaaattt ggatgtaagt agagactttc agtatttgtt     4080

ttctcttgat tttgaagtca tttcttcttc tcacgtctgt gacaaatggt tgaaaaggag     4140

tcaacatggc cccaactata gtgccggaac cttttcatca ttctgaggct ttgccccaca     4200

catggtcctc actcatatct gtcaccttct gaagcctaga tcttgttaac ccatcaggtg     4260

cagtgtcagt ttcaaatcaa attatctaag aaaacaagaa aacaaaggca gcagactatt     4320

ggtacacatt atagtccaaa gtgcttagcg aagtaaaaaa aaaagctttt taaaatttct     4380

attgttgtct attggtaatg tttttgatca gaataaagag ggtaaaggga aaaagttact     4440

acacatgcta ggctttctca gtggggaaaa aaatggctgg atagaactgg gacaaacaca     4500

gacccatctt taggggtctg gattttgtag gtccgactac acagcagtgt taactcattt     4560

ctcatgccat tagctctcta caaaataaag caaagtagtt ctagtgtggt cgttataaac     4620

caatattgtg aaaaatagca actattcatt tgttcacaac atgcgtattt atagagtagt     4680

taggtaccat ttgtaaggta aatcctttaa aattctataa tacatactaa aatagtggtt     4740

attggtctga tatatgctgc tcttggttct ataaactaga taaaagcagt gctttgtgaa     4800

atgcagtgtt ctctcttaac gccactggtg ataggaagta gttcccttca gttcaaatcc     4860

tgtgccctta tttgctgctt gctgacgtaa gcaataagta accctctaac taatggtatc     4920

tacatatttc tgtaacttgt atttaatgat ggtgtacctg gtgattgtaa aaatattaga     4980

cagatataaa agtatctata taatatctat aaactgttaa tgctgaggta tagtctgtga     5040

attatgtgtt ttgtattttt attcattgtg taatttagtg gtggtgaaag ttctacactc     5100

aatccttaaa gagtggcagt atcccttttt caatttaaca tggtctgcat caatctgttt     5160

gcctgctaaa caagttagaa taggaaatag taaaataaat ccaaacaaga gtgtaatatt     5220

ggttagggaa acaaacttca ggtcaccaac tgaagtcatt acaaactcct tgtacattca     5280

ctgtgagttt caaagggagt cagtccctaa tttacaggtt tcctttgttc actttctaga     5340

tgtgtacttt tgagggacat gaggttaggc aacattacag caacacacac tggggctatt     5400

aatcccattt aggtctgtac taaagaggat gggtagaaac acatatgtat ataccttttc     5460

tttacctaga agtgccatcc attgtccttg aattattatg attaaagtta ctgttgcatt     5520

taggaggctc cttgaaagta acaccttttc caaggacaat ggcaacaatg tcaatgtcaa     5580

cactgagtct aattttgacc acatttatag tggtatagtg tcaatactgc attttcatga     5640

caaccacact ccactgttga aacactgtgc cagtgagaag tgcaacatcc agtgggcaga     5700

tgaaaatgat gcatggccaa gttcagtgtt tacagataaa actgctgtgg ttcaagtgct     5760

tccttcccca tcaaatcctt gataaggctt tgtgggaaaa tgatctaaat tattgtttta     5820

atttttaaac ctaatttatt cactcagtga acattcttac ctaagcaagg ctataaaagg     5880

gaatactaca gttttgtcca cactttaatt tgagaccatt tttctttgaa tcgtaagtta     5940

gcaaaagaaa tttttttcac ctttgaaaat cacgtgatgt taaaggacaa atgcccactc     6000

ttctattctg atctgcaaat agcttaaatg tctcttgcaa aacaaagtaa gataccacca     6060

gtattacaac acaatgattt tccagacaaa tggtatggtg ttgaaaaata actgttactt     6120

cttaaagcag cattttatct tctattttga agactattta ttgtaataat tagaaaacat     6180

gaaataggga actccagact gacacagcag ttgtttttga aaaggaaata aactttgatg     6240

aattagataa tccagataca tcattgtaaa ctcttactct aggtgctctt tggtgagaga     6300

caggctttgt tctcttgttc ataacatttc tctgcaaaga attctctatg gagtgaagcg     6360

aatgaagtga ataatttctt accaaataaa tttatcaatt tacaaatctg ctctacatct     6420

cacttttgag ttcagttgta gtcatgagtg atccttcata ttttattaaa agtgttcatt     6480

caggtaaggt gtatgttgaa attttgccaa ttatcttaat aaaacctggc aatttaaaaa     6540


<210>  111
<211>  755
<212>  PRT
<213>  homo sapiens

<400>  111

Met Ala Gly Cys Ile Pro Glu Glu Lys Thr Tyr Arg Arg Phe Leu Glu 
1               5                   10                  15      


Leu Phe Leu Gly Glu Phe Arg Gly Pro Cys Gly Gly Gly Glu Pro Glu 
            20                  25                  30          


Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Ser Glu Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Leu Val Glu Ala Glu Ala Ala Glu Ala Ser Val Glu 
    50                  55                  60                  


Glu Pro Gly Glu Glu Ala Ala Thr Val Ala Ala Thr Glu Glu Gly Asp 
65                  70                  75                  80  


Gln Glu Gln Asp Pro Glu Pro Glu Glu Glu Ala Ala Val Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Gly Ala Ala Thr Ala Ala Ala Ala Pro Gly His Ser 
            100                 105                 110         


Ala Val Pro Pro Pro Pro Pro Gln Leu Pro Pro Leu Pro Pro Leu Pro 
        115                 120                 125             


Arg Pro Leu Ser Glu Arg Ile Thr Arg Glu Glu Val Glu Gly Glu Ser 
    130                 135                 140                 


Leu Asp Leu Cys Leu Gln Gln Leu Tyr Lys Tyr Asn Cys Pro Ser Phe 
145                 150                 155                 160 


Leu Ala Ala Ala Leu Ala Arg Ala Thr Ser Asp Glu Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Ser Ala His Tyr Ile Pro Lys Glu Thr Asp Gly Thr Glu Gly 
            180                 185                 190         


Thr Val Glu Ile Glu Thr Val Lys Leu Ala Arg Ser Val Phe Ser Lys 
        195                 200                 205             


Leu His Glu Ile Cys Cys Ser Trp Val Lys Asp Phe Pro Leu Arg Arg 
    210                 215                 220                 


Arg Pro Gln Leu Tyr Tyr Glu Thr Ser Ile His Ala Ile Lys Asn Met 
225                 230                 235                 240 


Arg Arg Lys Met Glu Asp Lys His Val Cys Ile Pro Asp Phe Asn Met 
                245                 250                 255     


Leu Phe Asn Leu Glu Asp Gln Glu Glu Gln Ala Tyr Phe Ala Val Phe 
            260                 265                 270         


Asp Gly His Gly Gly Val Asp Ala Ala Ile Tyr Ala Ser Ile His Leu 
        275                 280                 285             


His Val Asn Leu Val Arg Gln Glu Met Phe Pro His Asp Pro Ala Glu 
    290                 295                 300                 


Ala Leu Cys Arg Ala Phe Arg Val Thr Asp Glu Arg Phe Val Gln Lys 
305                 310                 315                 320 


Ala Ala Arg Glu Ser Leu Arg Cys Gly Thr Thr Gly Val Val Thr Phe 
                325                 330                 335     


Ile Arg Gly Asn Met Leu His Val Ala Trp Val Gly Asp Ser Gln Val 
            340                 345                 350         


Met Leu Val Arg Lys Gly Gln Ala Val Glu Leu Met Lys Pro His Lys 
        355                 360                 365             


Pro Asp Arg Glu Asp Glu Lys Gln Arg Ile Glu Ala Leu Gly Gly Cys 
    370                 375                 380                 


Val Val Trp Phe Gly Ala Trp Arg Val Asn Gly Ser Leu Ser Val Ser 
385                 390                 395                 400 


Arg Ala Ile Gly Asp Ala Glu His Lys Pro Tyr Ile Cys Gly Asp Ala 
                405                 410                 415     


Asp Ser Ala Ser Thr Val Leu Asp Gly Thr Glu Asp Tyr Leu Ile Leu 
            420                 425                 430         


Ala Cys Asp Gly Phe Tyr Asp Thr Val Asn Pro Asp Glu Ala Val Lys 
        435                 440                 445             


Val Val Ser Asp His Leu Lys Glu Asn Asn Gly Asp Ser Ser Met Val 
    450                 455                 460                 


Ala His Lys Leu Val Ala Ser Ala Arg Asp Ala Gly Ser Ser Asp Asn 
465                 470                 475                 480 


Ile Thr Val Ile Val Val Phe Leu Arg Asp Met Asn Lys Ala Val Asn 
                485                 490                 495     


Val Ser Glu Glu Ser Asp Trp Thr Glu Asn Ser Phe Gln Gly Gly Gln 
            500                 505                 510         


Glu Asp Gly Gly Asp Asp Lys Glu Asn His Gly Glu Cys Lys Arg Pro 
        515                 520                 525             


Trp Pro Gln His Gln Cys Ser Ala Pro Ala Asp Leu Gly Tyr Asp Gly 
    530                 535                 540                 


Arg Val Asp Ser Phe Thr Asp Arg Thr Ser Leu Ser Pro Gly Ser Gln 
545                 550                 555                 560 


Ile Asn Val Leu Glu Asp Pro Gly Tyr Leu Asp Leu Thr Gln Ile Glu 
                565                 570                 575     


Ala Ser Lys Pro His Ser Ala Gln Phe Leu Leu Pro Val Glu Met Phe 
            580                 585                 590         


Gly Pro Gly Ala Pro Lys Lys Ala Asn Leu Ile Asn Glu Leu Met Met 
        595                 600                 605             


Glu Lys Lys Ser Val Gln Ser Ser Leu Pro Glu Trp Ser Gly Ala Gly 
    610                 615                 620                 


Glu Phe Pro Thr Ala Phe Asn Leu Gly Ser Thr Gly Glu Gln Ile Tyr 
625                 630                 635                 640 


Arg Met Gln Ser Leu Ser Pro Val Cys Ser Gly Leu Glu Asn Glu Gln 
                645                 650                 655     


Phe Lys Ser Pro Gly Asn Arg Val Ser Arg Leu Ser His Leu Arg His 
            660                 665                 670         


His Tyr Ser Lys Lys Trp His Arg Phe Arg Phe Asn Pro Lys Phe Tyr 
        675                 680                 685             


Ser Phe Leu Ser Ala Gln Glu Pro Ser His Lys Ile Gly Thr Ser Leu 
    690                 695                 700                 


Ser Ser Leu Thr Gly Ser Gly Lys Arg Asn Arg Ile Arg Ser Ser Leu 
705                 710                 715                 720 


Pro Trp Arg Gln Asn Ser Trp Lys Gly Tyr Ser Glu Asn Met Arg Lys 
                725                 730                 735     


Leu Arg Lys Thr His Asp Ile Pro Cys Pro Asp Leu Pro Trp Ser Tyr 
            740                 745                 750         


Lys Ile Glu 
        755 


<210>  112
<211>  3233
<212>  DNA
<213>  homo sapiens

<400>  112
ggctggagag gcgtgataat agaaccagtg cttcaacagc aacttctctt ttgcaatcct       60

tgctggtctg acaggctcct gcagaattac atcacttcct aaaaaacagg cacacacctc      120

tccttcaagt cagcaccgac ccaaacaagc aggaaacagg aaatgttcac gtttcagaga      180

ggctgcagcc cggcgcagca tcctgagcgc gcctctgccg aggcgagcgg acatgcaggc      240

tccccgcgca gccctagtct tcgccctggt gatcgcgctc gttcccgtcg gccggggtaa      300

ttatgaggaa ttagaaaact caggagatac aactgtggaa tctgaaagac caaataaagt      360

gactattcca agcacatttg ctgcagtgac catcaaagaa acattaaatg caaatataaa      420

ttctaccaac tttgctccgg atgaaaatca gttagagttt atactgatgg tgttaatccc      480

attgatttta ttggtcctct tacttttatc cgtggtattc cttgcaacat actataaaag      540

aaaaagaact aaacaagaac cttctagcca aggatctcag agtgctttac agacatatga      600

actgggaagt gaaaacgtga aagtccctat ttttgaggaa gatacaccct ctgttatgga      660

aattgaaatg gaagagcttg ataaatggat gaacagcatg aatagaaatg ccgactttga      720

atgtttacct accttgaagg aagagaagga atcaaatcac aacccaagtg acagtgaatc      780

ctaaacctga atggcgctca tgttttccaa gagaagcagc ccctgaggga gtctgctgag      840

gctgccaaca gaggatgaag aggatacaaa tttaattaat ttcaaatcaa catagacaca      900

agaacctttt gctgtttctt ccaacgccca ctcttcctaa tgatggcatc acttgcactt      960

ggaagaatgt gcaattgaga agtactagga aaaggcctgg ctgccatcca tcgctgcctc     1020

tgagggtgga gaaggaggcg ggtgatgtgc tcacttctga tcaacatgtg ttgcctcctc     1080

tcagccaact tctagctcac tgcactcact ctggtcatga taaatgttcg tcacctttct     1140

gcttcattcc ttagggccta aatcaggaag ctgttttatc gatggtttcc ttttgggtca     1200

gtaaccagct ttggataatt tcctctgatt attcaagtcg tgggacaggt aaactacatt     1260

cagcaggaac ttttctcgag gagtgttatg tcatggaaaa gacaccaaac acagcaagta     1320

ttttaatgaa tacaccatcc cagggggtca gtaagctctg cctgccaaga agacacagtg     1380

agaggggtcc acagtcctga tgaggtggcg tttggtaact tgtagaccct agcatggcca     1440

ggtctggtca cccttaagaa cttctcagag aaactaggaa tcttcagtga aagaactaat     1500

gttctcctca gctgaaattc ccttgcttgt cagcatttct gcaaagctca cacttgtttc     1560

accatacctc ccttggatgt gacatgtagg taggaagtat gtgcaggtgg gagtcatctg     1620

tcagccttct atgtttcaga gatcctgaag gtggtttgaa acaaacagaa gaggagcagg     1680

aaatatccgt gcctgtggca gatctcactc atcatgctta gcattctctc ccgccaagct     1740

gggataagcc tcatgtccta acacagcaca acaggaggtc tctgtcagtc catcagagat     1800

gacattctat gtgatatttt tgacatcctt gtgctaaaag caatggcaca aaatggaaaa     1860

gggcctattg accacaccta ctccagtaaa attgttcttc atttattcct taattttcta     1920

aatctgaccc ctttaaagca atctagcaaa ttgagaatcc tcagctctcc ttggatacct     1980

gatattttat ttcaagaaag agacaaagaa ggaaaatttt atttatttta ctacccacat     2040

ataaaccgaa gggagatggg actacccaaa catttgctgc tcaattttgt gtcttgtgct     2100

tgaaagtctg ccctaatgca taacaaaaac tacttgtctc ctaccttttg ggatcccttt     2160

aacaagtatt tgccttctga actacgtgga taatttcaaa ggcagagttc cagaccagag     2220

aggtctttcc atacaatgaa agctataact agctggttgt gtttaaccac tgctatcacg     2280

ctatcctggg actgcataga actttgacaa aagacagact tcatggtaca caacttcaac     2340

agattttctg tcatattctc accagcacat ctgaatgagg ctttgtgttt tccttgctct     2400

cttgcatgtt ccttttcaac tcatggccca cagtgactct cagagattta tgccaaaatt     2460

gcatacaatt gttttctgaa tcataacttg tctatttttc tgcctatgtg tgctactttc     2520

agtttgtttc tcatcaacat tttgactctc agaagagcct ccatttgccc ctttctctct     2580

ttaggtatct aagatctttg aacacctgga cctttacatt tgatccaacc ctatcaaata     2640

atgaacttct cagagaggca tctggggtcc tggaacttca tgttgatgaa gtcatattat     2700

ataatatgat aaaaatattc tcatgcagta ttttaaataa tttcaaattc tagaagaagc     2760

aaatttcagc gacatgtcat tgagttttta tttggtaaag ctataattgt gcagtgtaca     2820

aagcactttt taaaaagata gtttattctg tcagggtata tgaagttagt atacagccag     2880

aacagccaag cctcaattct tgtaccttgt gtctttttat tactgtttaa tcaatagata     2940

tcatatgttt atgacagttt caagaattgt ttttaaaccc aaacttaatt ttatgtttca     3000

gactattgtt agaaaaacaa aacaaaaaac aaaaaaaccc tcactaattt gccctaattg     3060

gatagggcaa tcagaacaaa atctgacttt cgaatattta aaagatatgt aagtttgatt     3120

gcattttcgt acattttaag caaactaggt taacaacaac atagcctagt caaacttctc     3180

aggaaacttg ttttaataaa tatgtaaaaa tacccaaaaa aaaaaaaaaa aaa            3233


<210>  113
<211>  183
<212>  PRT
<213>  homo sapiens

<400>  113

Met Gln Ala Pro Arg Ala Ala Leu Val Phe Ala Leu Val Ile Ala Leu 
1               5                   10                  15      


Val Pro Val Gly Arg Gly Asn Tyr Glu Glu Leu Glu Asn Ser Gly Asp 
            20                  25                  30          


Thr Thr Val Glu Ser Glu Arg Pro Asn Lys Val Thr Ile Pro Ser Thr 
        35                  40                  45              


Phe Ala Ala Val Thr Ile Lys Glu Thr Leu Asn Ala Asn Ile Asn Ser 
    50                  55                  60                  


Thr Asn Phe Ala Pro Asp Glu Asn Gln Leu Glu Phe Ile Leu Met Val 
65                  70                  75                  80  


Leu Ile Pro Leu Ile Leu Leu Val Leu Leu Leu Leu Ser Val Val Phe 
                85                  90                  95      


Leu Ala Thr Tyr Tyr Lys Arg Lys Arg Thr Lys Gln Glu Pro Ser Ser 
            100                 105                 110         


Gln Gly Ser Gln Ser Ala Leu Gln Thr Tyr Glu Leu Gly Ser Glu Asn 
        115                 120                 125             


Val Lys Val Pro Ile Phe Glu Glu Asp Thr Pro Ser Val Met Glu Ile 
    130                 135                 140                 


Glu Met Glu Glu Leu Asp Lys Trp Met Asn Ser Met Asn Arg Asn Ala 
145                 150                 155                 160 


Asp Phe Glu Cys Leu Pro Thr Leu Lys Glu Glu Lys Glu Ser Asn His 
                165                 170                 175     


Asn Pro Ser Asp Ser Glu Ser 
            180             


<210>  114
<211>  1951
<212>  DNA
<213>  homo sapiens

<400>  114
gagcccggag caggccgggc tcaagaaaga ggaaagttga ggacgcccca cctcggagag       60

gcggcgcccc tgagtaggcc aggagcctct cttgcaactt ctgccaccgc gggccaccgc      120

ggccgcctga tcccgcagag gaaggtcgcg gccgtggagc gatgacccgc ggcggtccgg      180

gcgggcgccc ggggctgcca cagccgccgc cgcttctgct gctgctgctg ctgctgccgc      240

tgttgttagt caccgcggag ccgccgaaac ctgcaggagt ctactatgca actgcatact      300

ggatgcctgc tgaaaagaca gtacaagtca aaaatgtaat ggacaagaat ggggacgcct      360

atggctttta caataactct gtgaaaacca caggctgggg catcctggag atcagagctg      420

gctatggctc tcaaaccctg agcaatgaga tcatcatgtt tgtggctggc tttttggagg      480

gttacctcac tgccccacac atgaatgacc actacacaaa cctctaccca cagctgatca      540

cgaaaccttc catcatggat aaagtgcagg attttatgga gaagcaagat aagtggaccc      600

ggaaaaatat caaagaatac aagactgatt cattttggag acatacaggc tatgtgatgg      660

cacaaataga tggcctctat gtaggagcaa agaagagggc tatattagaa gggacaaagc      720

caatgaccct gttccagatt cagttcctga atagtgttgg agatctattg gatctgattc      780

cctcactctc tcccacaaaa aacggcagcc taaaggtttt taagagatgg gacatgggac      840

attgctccgc tcttatcaag gttcttcctg gatttgagaa catccttttt gctcactcaa      900

gctggtacac gtatgcagcc atgctcagga tatataaaca ctgggacttc aacgtcatag      960

ataaagatac cagcagtagt cgcctctctt tcagcagtta cccagggttt ttggagtctc     1020

tggatgattt ttacattctt agcagtggat tgatattgct gcagaccaca aacagtgtgt     1080

ttaataaaac cctgctaaag caggtaatac ccgagactct cctgtcctgg caaagagtcc     1140

gtgtggccaa tatgatggca gatagtggca agaggtgggc agacatcttt tcaaaataca     1200

actctggcac ctataacaat caatacatgg ttctggacct gaagaaagta aagctgaacc     1260

acagtcttga caaaggcact ctgtacattg tggagcaaat tcctacatat gtagaatatt     1320

ctgaacaaac tgatgttcta cggaaaggat attggccctc ctacaatgtt cctttccatg     1380

aaaaaatcta caactggagt ggctatccac tgttagttca gaagctgggc ttggactact     1440

cttatgattt agctccacga gccaaaattt tccggcgtga ccaagggaaa gtgactgata     1500

cggcatccat gaaatatatc atgcgataca acaattataa gaaggatcct tacagtagag     1560

gtgacccctg taataccatc tgctgccgtg aggacctgaa ctcacctaac ccaagtcctg     1620

gaggttgtta tgacacaaag gtggcagata tctacctagc atctcagtac acatcctatg     1680

ccataagtgg tcccacagta caaggtggcc tccctgtttt tcgctgggac cgtttcaaca     1740

aaactctaca tcagggcatg ccagaggtct acaactttga ttttattacc atgaaaccaa     1800

ttttgaaact tgatataaaa tgaaggaggg agatgacgga ctagaagact gtaaataaga     1860

taccaaaggc actattttag ctatgttttt cccatcagaa ttatgcaata aaatatatta     1920

atttgtcact ttaaaaaaaa aaaaaaaaaa a                                    1951


<210>  115
<211>  553
<212>  PRT
<213>  homo sapiens

<400>  115

Met Thr Arg Gly Gly Pro Gly Gly Arg Pro Gly Leu Pro Gln Pro Pro 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu Leu Val Thr Ala 
            20                  25                  30          


Glu Pro Pro Lys Pro Ala Gly Val Tyr Tyr Ala Thr Ala Tyr Trp Met 
        35                  40                  45              


Pro Ala Glu Lys Thr Val Gln Val Lys Asn Val Met Asp Lys Asn Gly 
    50                  55                  60                  


Asp Ala Tyr Gly Phe Tyr Asn Asn Ser Val Lys Thr Thr Gly Trp Gly 
65                  70                  75                  80  


Ile Leu Glu Ile Arg Ala Gly Tyr Gly Ser Gln Thr Leu Ser Asn Glu 
                85                  90                  95      


Ile Ile Met Phe Val Ala Gly Phe Leu Glu Gly Tyr Leu Thr Ala Pro 
            100                 105                 110         


His Met Asn Asp His Tyr Thr Asn Leu Tyr Pro Gln Leu Ile Thr Lys 
        115                 120                 125             


Pro Ser Ile Met Asp Lys Val Gln Asp Phe Met Glu Lys Gln Asp Lys 
    130                 135                 140                 


Trp Thr Arg Lys Asn Ile Lys Glu Tyr Lys Thr Asp Ser Phe Trp Arg 
145                 150                 155                 160 


His Thr Gly Tyr Val Met Ala Gln Ile Asp Gly Leu Tyr Val Gly Ala 
                165                 170                 175     


Lys Lys Arg Ala Ile Leu Glu Gly Thr Lys Pro Met Thr Leu Phe Gln 
            180                 185                 190         


Ile Gln Phe Leu Asn Ser Val Gly Asp Leu Leu Asp Leu Ile Pro Ser 
        195                 200                 205             


Leu Ser Pro Thr Lys Asn Gly Ser Leu Lys Val Phe Lys Arg Trp Asp 
    210                 215                 220                 


Met Gly His Cys Ser Ala Leu Ile Lys Val Leu Pro Gly Phe Glu Asn 
225                 230                 235                 240 


Ile Leu Phe Ala His Ser Ser Trp Tyr Thr Tyr Ala Ala Met Leu Arg 
                245                 250                 255     


Ile Tyr Lys His Trp Asp Phe Asn Val Ile Asp Lys Asp Thr Ser Ser 
            260                 265                 270         


Ser Arg Leu Ser Phe Ser Ser Tyr Pro Gly Phe Leu Glu Ser Leu Asp 
        275                 280                 285             


Asp Phe Tyr Ile Leu Ser Ser Gly Leu Ile Leu Leu Gln Thr Thr Asn 
    290                 295                 300                 


Ser Val Phe Asn Lys Thr Leu Leu Lys Gln Val Ile Pro Glu Thr Leu 
305                 310                 315                 320 


Leu Ser Trp Gln Arg Val Arg Val Ala Asn Met Met Ala Asp Ser Gly 
                325                 330                 335     


Lys Arg Trp Ala Asp Ile Phe Ser Lys Tyr Asn Ser Gly Thr Tyr Asn 
            340                 345                 350         


Asn Gln Tyr Met Val Leu Asp Leu Lys Lys Val Lys Leu Asn His Ser 
        355                 360                 365             


Leu Asp Lys Gly Thr Leu Tyr Ile Val Glu Gln Ile Pro Thr Tyr Val 
    370                 375                 380                 


Glu Tyr Ser Glu Gln Thr Asp Val Leu Arg Lys Gly Tyr Trp Pro Ser 
385                 390                 395                 400 


Tyr Asn Val Pro Phe His Glu Lys Ile Tyr Asn Trp Ser Gly Tyr Pro 
                405                 410                 415     


Leu Leu Val Gln Lys Leu Gly Leu Asp Tyr Ser Tyr Asp Leu Ala Pro 
            420                 425                 430         


Arg Ala Lys Ile Phe Arg Arg Asp Gln Gly Lys Val Thr Asp Thr Ala 
        435                 440                 445             


Ser Met Lys Tyr Ile Met Arg Tyr Asn Asn Tyr Lys Lys Asp Pro Tyr 
    450                 455                 460                 


Ser Arg Gly Asp Pro Cys Asn Thr Ile Cys Cys Arg Glu Asp Leu Asn 
465                 470                 475                 480 


Ser Pro Asn Pro Ser Pro Gly Gly Cys Tyr Asp Thr Lys Val Ala Asp 
                485                 490                 495     


Ile Tyr Leu Ala Ser Gln Tyr Thr Ser Tyr Ala Ile Ser Gly Pro Thr 
            500                 505                 510         


Val Gln Gly Gly Leu Pro Val Phe Arg Trp Asp Arg Phe Asn Lys Thr 
        515                 520                 525             


Leu His Gln Gly Met Pro Glu Val Tyr Asn Phe Asp Phe Ile Thr Met 
    530                 535                 540                 


Lys Pro Ile Leu Lys Leu Asp Ile Lys 
545                 550             


<210>  116
<211>  1463
<212>  DNA
<213>  homo sapiens

<400>  116
ccggtcccag agccgcagct gctgcgcccg cgcgctcccg gggacattct aaccgccgcc       60

aggtcccgcc gcctctcgcc ccgctattaa taccggcggc ccgggagggg ggcgcagcac      120

gcgccgcgca gccatgggga ggctgctggc cttagtggtc ggcgcggcac tggtgtcctc      180

agcctgcggg ggctgcgtgg aggtggactc ggagaccgag gccgtgtatg ggatgacctt      240

caaaattctt tgcatctcct gcaagcgccg cagcgagacc aacgctgaga ccttcaccga      300

gtggaccttc cgccagaagg gcactgagga gtttgtcaag atcctgcgct atgagaatga      360

ggtgttgcag ctggaggagg atgagcgctt cgagggccgc gtggtgtgga atggcagccg      420

gggcaccaaa gacctgcagg atctgtctat cttcatcacc aatgtcacct acaaccactc      480

gggcgactac gagtgccacg tctaccgcct gctcttcttc gaaaactacg agcacaacac      540

cagcgtcgtc aagaagatcc acattgaggt agtggacaaa gccaacagag acatggcatc      600

catcgtgtct gagatcatga tgtatgtgct cattgtggtg ttgaccatat ggctcgtggc      660

agagatgatt tactgctaca agaagatcgc tgccgccacg gagactgctg cacaggagaa      720

tgcctcggaa tacctggcca tcacctctga aagcaaagag aactgcacgg gcgtccaggt      780

ggccgaatag ccctggccct gggccccgcc tcaaggaaga gccagccgta atggggactc      840

tccaggcacc gcctgccccc agcgtggggg tggccactcc tgggccccag aaagcctcag      900

agtcctgccg acggagccac tggggtggga gggggcaggg ggcttggctc gcacccccac      960

tttcgcctcc tccagctcct gccccgccgg ccgcgcaccg ccatgcatga tgggtaaagc     1020

aatactgccg ctgcccccac cctgcttctg ctgcctgttt ggggaggggg gcggtgaggt     1080

gggggcagcg gccccgcacc cctcctcctt gctgatttgc acacattggc cgcttcagac     1140

acgcacttct ggggccagcc cctccccgcc tcctccctgc ctggcggcag gggtcgcgat     1200

gatgggctgg agcagtttgg ggcagggggt tctgggaccc actccgactc cccctccccg     1260

gcatcatttc ccctcccgct tcctccggct ggacctgggg tcccccctcc ctgtaatgca     1320

ctcctgcccc ggcccaacct cgccctctct caccagcctt gaactgtggc cacctagaaa     1380

ggggcccatt cagcctcgtc tctttacaga agtagttttg ttcatgaaat aaagactctt     1440

ggacttgaaa aaaaaaaaaa aaa                                             1463


<210>  117
<211>  218
<212>  PRT
<213>  homo sapiens

<400>  117

Met Gly Arg Leu Leu Ala Leu Val Val Gly Ala Ala Leu Val Ser Ser 
1               5                   10                  15      


Ala Cys Gly Gly Cys Val Glu Val Asp Ser Glu Thr Glu Ala Val Tyr 
            20                  25                  30          


Gly Met Thr Phe Lys Ile Leu Cys Ile Ser Cys Lys Arg Arg Ser Glu 
        35                  40                  45              


Thr Asn Ala Glu Thr Phe Thr Glu Trp Thr Phe Arg Gln Lys Gly Thr 
    50                  55                  60                  


Glu Glu Phe Val Lys Ile Leu Arg Tyr Glu Asn Glu Val Leu Gln Leu 
65                  70                  75                  80  


Glu Glu Asp Glu Arg Phe Glu Gly Arg Val Val Trp Asn Gly Ser Arg 
                85                  90                  95      


Gly Thr Lys Asp Leu Gln Asp Leu Ser Ile Phe Ile Thr Asn Val Thr 
            100                 105                 110         


Tyr Asn His Ser Gly Asp Tyr Glu Cys His Val Tyr Arg Leu Leu Phe 
        115                 120                 125             


Phe Glu Asn Tyr Glu His Asn Thr Ser Val Val Lys Lys Ile His Ile 
    130                 135                 140                 


Glu Val Val Asp Lys Ala Asn Arg Asp Met Ala Ser Ile Val Ser Glu 
145                 150                 155                 160 


Ile Met Met Tyr Val Leu Ile Val Val Leu Thr Ile Trp Leu Val Ala 
                165                 170                 175     


Glu Met Ile Tyr Cys Tyr Lys Lys Ile Ala Ala Ala Thr Glu Thr Ala 
            180                 185                 190         


Ala Gln Glu Asn Ala Ser Glu Tyr Leu Ala Ile Thr Ser Glu Ser Lys 
        195                 200                 205             


Glu Asn Cys Thr Gly Val Gln Val Ala Glu 
    210                 215             


<210>  118
<211>  4396
<212>  DNA
<213>  homo sapiens

<400>  118
ggcgcggcgg ggcgcggggc gtggggacgc tagcgggcgc cggacgggcg cggcgccccg       60

tcacgggcag cgccccgaac cggggccgga cacctcggcc gctcgggccg cggcggcggg      120

gaccatgccg aagaaagtct cctgagcccg gcaacttcgg cccctccccg cccccacccg      180

gctgccctcc gcgcggccct ccccatgtgc agccggccag ccgggctctc ctcctcgcgg      240

cggatgggtg accttttcct ggcacgggca ggctgtggga ggcagcggag caggcgatga      300

agaagaagca gcagcatccc ggcggcggcg cggatccctg gccccatggg gcccctatgg      360

ggggcgcccc tccgggcctg ggcagctgga agcgtcgggt gcccctgctg cctttcctgc      420

gcttctccct ccgggactac ggcttctgca tggccaccct gctggtcttc tgcctgggct      480

ccctcctcta tcagctcagc gggggacccc ctcgcttcct gctcgacctg cggcagtact      540

tgggaaattc cacttacttg gatgaccatg gaccacctcc tagtaaggta ctacctttcc      600

caagccaggt ggtgtacaac agggtaggca agtgtgggag ccgtactgtg gtcttgcttc      660

tgagaatctt gtcggagaag cacggattta atttggtcac atcagacatt cacaacaaaa      720

ccaggcttac taaaaatgaa caaatggaac tgattaaaaa tataagtact gccgaacaac      780

cctatttatt cactcgacat gttcatttcc tcaacttctc aaggtttgga ggagaccagc      840

ctgtctacat caacatcatt agagaccccg tcaaccggtt cttatccaac tattttttcc      900

gtcgctttgg agactggaga ggggaacaaa atcacatgat ccgcaccccc agcatgaggc      960

aggaggagcg ctacctggat atcaatgagt gtattcttga aaactatccc gagtgctcca     1020

accccaggtt attttacatc attccgtact tttgtggaca gcatcccaga tgcagggagc     1080

ctggtgaatg ggcccttgag agagcaaagc tgaacgtgaa tgaaaacttc ctgctcgtgg     1140

ggattcttga agagttggaa gatgtgctgc tgttactgga aagattttta cctcattact     1200

tcaagggcgt gctcagtatc tacaaagacc cagagcacag gaagcttgga aacatgactg     1260

tgacggtgaa gaagactgtc ccctctcctg aggctgtgca gatcctctac cagcggatga     1320

gatacgagta cgagttttac cactacgtca aagagcagtt ccacctgctg aagcgcaagt     1380

ttggacttaa gtctcacgtc agcaagcccc ccctgaggcc acacttcttt atcccaactc     1440

cactggaaac cgaggagcca atcgacgatg aagaacagga tgatgaaaag tggctggaag     1500

atatttataa gaggtgatgt gactgtgttg cctctatggc tttatctccc ttttccagaa     1560

agttctttgt ttggggaagt aaaatcctta agggactaaa ttaatgcttg ggtgcattaa     1620

aaagaacaaa acattcccac atgttggggt cattgggaga tgcccggttt tgcgggtttt     1680

atttgtttaa ttttattctg tgttttctct tggctctttg ggtctttccc gggtacacta     1740

gatggctcca tcccaaggca tcttgtcata aaacagcttt cccccacccc atatcatggg     1800

aaaaggggga gaaatatagc ccctagccta ataacttatc atttgtaaaa tgacttataa     1860

aaatattacc tcaatggtag gagacatcca gacttgtata tttcagtgga aatacaaaac     1920

cacttcagag accagggtat ctcctctgga aggatctaag agaaggtaag acagattagg     1980

acatcgaaaa ggaggatgga gccaggtgcc atggcttgag cctataatcc gaggctgagg     2040

tgggaggatc acttgagccc aggagtttga ggttgcagtg agctgtgatc acaccactgc     2100

actccagcct gggtgacaga gtgagactct gtctcaatta attttttttt tttaaaggag     2160

gaggatctcc atgggtaagt ggtttctacc cgcatgggta gagttctgcc tctggtcctt     2220

ctcagggggc actttcacca agagcagtgt aattatctct gaaagagcaa gtcagcttgt     2280

gccgcatccc caaccaatcc acagcctgga gtacctttca aggtcaaagt gcatggccag     2340

ctccattgag acattccatt tcaaagcacc gtgctgacag atatcaaagt actctagcag     2400

ggaaaataat ttgtttgctg tgtaaggaag aatgtagaca agacagataa atctgaaggt     2460

catgtggcat cagggaaagg gcatggctgt gtcttttgca cccaatatga aacatcttct     2520

cccaacactg ctttaatgga agttctagga accaatttag ctcaggcatt tgactcctac     2580

agcagaagtt ctgagcctga ccacagatgg tgtgtaatct atcaaacaca cccctggcca     2640

agttgggtcc tataggacct ggtactatgt actattgtaa cttctagttc cctaagaggt     2700

acctgttttc agtaaaaagg ggtcctgagt tctgtgcagg tggaagagct acccgagaac     2760

tacctgagtt ctgtgcaggt agagtcccat ttcttatggg acctgtgtgc tcctgagaac     2820

tcttacttga gacatcaaaa agaagcagca agagcttctg ggacagagac tgcttggcca     2880

gctttgtaag taagtggctg cctccaatgt gatgtgagta catgttgggc agtctcactg     2940

tcctaaggta tgtcttcttt ccacctccca ctgcccctcc cctgccacct atcaatgatg     3000

ccttggttca gtcattagaa atctgttgct ttgagttctg aaatattttc accttaaaaa     3060

aaatgctgaa aatacacatt ctcctgggaa gacgataaac agctagctaa gaagccgagg     3120

ttcagtggtg gcagcaggaa ggacactgcc acaaattttg tctatttcat atttgtcccc     3180

tagagccagc cctagcaaat gtgtgagttg ggagtagtta atagtaaata agactctgac     3240

tttacacaag ctacacattt tatacttttc ataaaccaca aagtctctct agaatttttt     3300

ctgccttcac taaaattgga ctgtagccaa gatataaagc aagtcatttg gaacctgccg     3360

agtgagcact gaagctactt tatcatgaga tgtgtgttaa gaaggctgca gcccacagga     3420

gtccagggaa ggcggggacc acagaggcac agagtccagc acttggccgc tcatgggcct     3480

tctttctgcc tcagaggacg ggggcagaga agtgatgaag ggaaatgttc ttagaggagg     3540

aaatatcctt tgtcctgttc agagagacca gggccctacc attaggcata ctttcagaag     3600

caacctggag aacagctatc aatcatattc aaaaccagta caagaactgc tgcctggtac     3660

cctgtgagtc atttctatga aattccatat aaagaatgat gataagttta cacactgtgc     3720

aatctcacaa tctgaaaata aagttgagtt ggctgtgttt tctctgctct tgtcagaaca     3780

ttgggacaat tggtcgttca aaaacattca tcctcttact gcaagtttat ctgggtactt     3840

ttacctgtgt gttcaaaggc atttcttttc agcagtgatc attataactt cacaaaaaaa     3900

gatgctgacg gatttactta cagggcctta atgttatttt gtcccagcca acaccctcta     3960

ggtcctaaaa gtcaaggtac ttcagtttat ttggcaaaca tgacaacatt ttttttggcc     4020

ctgggcccaa cagtttgtac ttcatgaaac atattgtaca ttttacatag tttaatttaa     4080

aaaatacctt ttaagctagt tgatctttga ctgtcttatt tattataacc tttcagcaca     4140

ttccaaggtt ttagttactc aggaaggagt taattaaaat gattttattt tggtctgatg     4200

gatgtttttt aaaaggaaaa ttattattat gaaccttcag cctactttct tgagtgccgt     4260

aaaagtgctt gtaaatcttt tttttttttt aagaagaaag aaaaaaatgg tgtttgacgt     4320

tgatggaaat tcaaaaatat atatggaact gaaacattaa cttagctaaa ataaaagcaa     4380

tctgtgtttg aaaaaa                                                     4396


<210>  119
<211>  406
<212>  PRT
<213>  homo sapiens

<400>  119

Met Lys Lys Lys Gln Gln His Pro Gly Gly Gly Ala Asp Pro Trp Pro 
1               5                   10                  15      


His Gly Ala Pro Met Gly Gly Ala Pro Pro Gly Leu Gly Ser Trp Lys 
            20                  25                  30          


Arg Arg Val Pro Leu Leu Pro Phe Leu Arg Phe Ser Leu Arg Asp Tyr 
        35                  40                  45              


Gly Phe Cys Met Ala Thr Leu Leu Val Phe Cys Leu Gly Ser Leu Leu 
    50                  55                  60                  


Tyr Gln Leu Ser Gly Gly Pro Pro Arg Phe Leu Leu Asp Leu Arg Gln 
65                  70                  75                  80  


Tyr Leu Gly Asn Ser Thr Tyr Leu Asp Asp His Gly Pro Pro Pro Ser 
                85                  90                  95      


Lys Val Leu Pro Phe Pro Ser Gln Val Val Tyr Asn Arg Val Gly Lys 
            100                 105                 110         


Cys Gly Ser Arg Thr Val Val Leu Leu Leu Arg Ile Leu Ser Glu Lys 
        115                 120                 125             


His Gly Phe Asn Leu Val Thr Ser Asp Ile His Asn Lys Thr Arg Leu 
    130                 135                 140                 


Thr Lys Asn Glu Gln Met Glu Leu Ile Lys Asn Ile Ser Thr Ala Glu 
145                 150                 155                 160 


Gln Pro Tyr Leu Phe Thr Arg His Val His Phe Leu Asn Phe Ser Arg 
                165                 170                 175     


Phe Gly Gly Asp Gln Pro Val Tyr Ile Asn Ile Ile Arg Asp Pro Val 
            180                 185                 190         


Asn Arg Phe Leu Ser Asn Tyr Phe Phe Arg Arg Phe Gly Asp Trp Arg 
        195                 200                 205             


Gly Glu Gln Asn His Met Ile Arg Thr Pro Ser Met Arg Gln Glu Glu 
    210                 215                 220                 


Arg Tyr Leu Asp Ile Asn Glu Cys Ile Leu Glu Asn Tyr Pro Glu Cys 
225                 230                 235                 240 


Ser Asn Pro Arg Leu Phe Tyr Ile Ile Pro Tyr Phe Cys Gly Gln His 
                245                 250                 255     


Pro Arg Cys Arg Glu Pro Gly Glu Trp Ala Leu Glu Arg Ala Lys Leu 
            260                 265                 270         


Asn Val Asn Glu Asn Phe Leu Leu Val Gly Ile Leu Glu Glu Leu Glu 
        275                 280                 285             


Asp Val Leu Leu Leu Leu Glu Arg Phe Leu Pro His Tyr Phe Lys Gly 
    290                 295                 300                 


Val Leu Ser Ile Tyr Lys Asp Pro Glu His Arg Lys Leu Gly Asn Met 
305                 310                 315                 320 


Thr Val Thr Val Lys Lys Thr Val Pro Ser Pro Glu Ala Val Gln Ile 
                325                 330                 335     


Leu Tyr Gln Arg Met Arg Tyr Glu Tyr Glu Phe Tyr His Tyr Val Lys 
            340                 345                 350         


Glu Gln Phe His Leu Leu Lys Arg Lys Phe Gly Leu Lys Ser His Val 
        355                 360                 365             


Ser Lys Pro Pro Leu Arg Pro His Phe Phe Ile Pro Thr Pro Leu Glu 
    370                 375                 380                 


Thr Glu Glu Pro Ile Asp Asp Glu Glu Gln Asp Asp Glu Lys Trp Leu 
385                 390                 395                 400 


Glu Asp Ile Tyr Lys Arg 
                405     


<210>  120
<211>  2826
<212>  DNA
<213>  homo sapiens

<400>  120
acaagggtgg cagcctggct ctgaagtgga attatgtgct tcaaacaggt tgaaagaggg       60

aaacagtctt ttcctgcttc cagacatgaa tcaggtcact attcaatggg atgcagtaat      120

agccctttac atactcttca gctggtgtca tggaggaatt acaaatataa actgctctgg      180

ccacatctgg gtagaaccag ccacaatttt taagatgggt atgaatatct ctatatattg      240

ccaagcagca attaagaact gccaaccaag gaaacttcat ttttataaaa atggcatcaa      300

agaaagattt caaatcacaa ggattaataa aacaacagct cggctttggt ataaaaactt      360

tctggaacca catgcttcta tgtactgcac tgctgaatgt cccaaacatt ttcaagagac      420

actgatatgt ggaaaagaca tttcttctgg atatccgcca gatattcctg atgaagtaac      480

ctgtgtcatt tatgaatatt caggcaacat gacttgcacc tggaatgctg ggaagctcac      540

ctacatagac acaaaatacg tggtacatgt gaagagttta gagacagaag aagagcaaca      600

gtatctcacc tcaagctata ttaacatctc cactgattca ttacaaggtg gcaagaagta      660

cttggtttgg gtccaagcag caaacgcact aggcatggaa gagtcaaaac aactgcaaat      720

tcacctggat gatatagtga taccttctgc agccgtcatt tccagggctg agactataaa      780

tgctacagtg cccaagacca taatttattg ggatagtcaa acaacaattg aaaaggtttc      840

ctgtgaaatg agatacaagg ctacaacaaa ccaaacttgg aatgttaaag aatttgacac      900

caattttaca tatgtgcaac agtcagaatt ctacttggag ccaaacatta agtacgtatt      960

tcaagtgaga tgtcaagaaa caggcaaaag gtactggcag ccttggagtt cactgttttt     1020

tcataaaaca cctgaaacag ttccccaggt cacatcaaaa gcattccaac atgacacatg     1080

gaattctggg ctaacagttg cttccatctc tacagggcac cttacttctg acaacagagg     1140

agacattgga cttttattgg gaatgatcgt ctttgctgtt atgttgtcaa ttctttcttt     1200

gattgggata tttaacagat cattccgaac tgggattaaa agaaggatct tattgttaat     1260

accaaagtgg ctttatgaag atattcctaa tatgaaaaac agcaatgttg tgaaaatgct     1320

acaggaaaat agtgaactta tgaataataa ttccagtgag caggtcctat atgttgatcc     1380

catgattaca gagataaaag aaatcttcat cccagaacac aagcctacag actacaagaa     1440

ggagaataca ggacccctgg agacaagaga ctacccgcaa aactcgctat tcgacaatac     1500

tacagttgta tatattcctg atctcaacac tggatataaa ccccaaattt caaattttct     1560

gcctgaggga agccatctca gcaataataa tgaaattact tccttaacac ttaaaccacc     1620

agttgattcc ttagactcag gaaataatcc caggttacaa aagcatccta attttgcttt     1680

ttctgtttca agtgtgaatt cactaagcaa cacaatattt cttggagaat taagcctcat     1740

attaaatcaa ggagaatgca gttctcctga catacaaaac tcagtagagg aggaaaccac     1800

catgcttttg gaaaatgatt cacccagtga aactattcca gaacagaccc tgcttcctga     1860

tgaatttgtc tcctgtttgg ggatcgtgaa tgaggagttg ccatctatta atacttattt     1920

tccacaaaat attttggaaa gccacttcaa taggatttca ctcttggaaa agtagagctg     1980

tgtggtcaaa atcaatatga gaaagctgcc ttgcaatctg aacttgggtt ttccctgcaa     2040

tagaaattga attctgcctc tttttgaaaa aaatgtattc acatacaaat cttcacatgg     2100

acacatgttt tcatttccct tggataaata cctaggtagg ggattgctgg gccatatgat     2160

aagcatatgt ttcagttcta ccaatcttgt ttccagagta gtgacatttc tgtgctccta     2220

ccatcaccat gtaagaattc ccgggagctc catgcctttt taattttagc cattcttctg     2280

cctcatttct taaaattaga gaattaaggt cccgaaggtg gaacatgctt catggtcaca     2340

catacaggca caaaaacagc attatgtgga cgcctcatgt attttttata gagtcaacta     2400

tttcctcttt attttccctc attgaaagat gcaaaacagc tctctattgt gtacagaaag     2460

ggtaaataat gcaaaatacc tggtagtaaa ataaatgctg aaaattttcc tttaaaatag     2520

aatcattagg ccaggcgtgg tggctcatgc ttgtaatccc agcactttgg taggctgagg     2580

taggtggatc acctgaggtc aggagttcga gtccagcctg gccaatatgc tgaaaccctg     2640

tctctactaa aattacaaaa attagccggc catggtggca ggtgcttgta atcccagcta     2700

cttgggaggc tgaggcagga gaatcacttg aaccaggaag gcagaggttg cactgagctg     2760

agattgtgcc actgcactcc agcctgggca acaagagcaa aactctgtct ggaaaaaaaa     2820

aaaaaa                                                                2826


<210>  121
<211>  629
<212>  PRT
<213>  homo sapiens

<400>  121

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  122
<211>  1606
<212>  DNA
<213>  homo sapiens

<400>  122
actaagtatc tccactttca attctagatc aggaactgag gacatatcta aattttctag       60

ttttatagaa ggcttttatc cacaagaatc aagatcttcc ctctctgagc aggaatcctt      120

tgtgcattga agactttaga ttcctctctg cggtagacgt gcacttataa gtatttgatg      180

gggtggattc gtggtcggag gtctcgacac agctgggaga tgagtgaatt tcataattat      240

aacttggatc tgaagaagag tgatttttca acacgatggc aaaagcaaag atgtccagta      300

gtcaaaagca aatgtagaga aaatgcatct ccattttttt tctgctgctt catcgctgta      360

gccatgggaa tccgtttcat tattatggta acaatatgga gtgctgtatt cctaaactca      420

ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa      480

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      540

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      600

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      660

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      720

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      780

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtgtaaag atgatcaacc      840

atctcaataa aagccaggaa cagagaagag attacaccag cggtaacact gccaactgag      900

actaaaggaa acaaacaaaa acaggacaaa atgaccaaag actgtcagat ttcttagact      960

ccacaggacc aaaccataga acaatttcac tgcaaacatg catgattctc caagacaaaa     1020

gaagagagat cctaaaggca attcagatat ccccaaggct gcctctccca ccacaagccc     1080

agagtggatg ggctggggga ggggtgctgt tttaatttct aaaggtagga ccaacaccca     1140

ggggatcagt gaaggaagag aaggccagca gatcactgag agtgcaaccc caccctccac     1200

aggaaattgc ctcatgggca gggccacagc agagagacac agcatgggca gtgccttccc     1260

tgcctgtggg ggtcatgctg ccacttttaa tgggtcctcc acccaacggg gtcagggagg     1320

tggtgctgcc ccagtgggcc atgattatct taaaggcatt attctccagc cttaagtaag     1380

atcttaggac gtttcctttg ctatgatttg tacttgcttg agtcccatga ctgtttctct     1440

tcctctcttt cttccttttg gaatagtaat atccatccta tgtttgtccc actattgtat     1500

tttggaagca cataacttgt ttggtttcac aggttcacag ttaagaagga attttgcctc     1560

tgaataaata gaatcttgag tctcatgcaa aaaaaaaaaa aaaaaa                    1606


<210>  123
<211>  216
<212>  PRT
<213>  homo sapiens

<400>  123

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  124
<211>  3254
<212>  DNA
<213>  Homo sapiens

<400>  124
agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac       60

ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc      120

cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg      180

ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca      240

gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga      300

gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa      360

tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg tcctggacta      420

tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg      480

agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc      540

gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc      600

cctccgcatg agagacgcgg gcctcctggt ggagcagccg cccctggccg gggtggccgc      660

cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt      720

gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac      780

ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa      840

catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc      900

cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc      960

gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc     1020

ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga     1080

ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct     1140

gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc     1200

tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc     1260

ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc     1320

catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag     1380

catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc     1440

ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga     1500

aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg     1560

ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat     1620

ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac     1680

cagctatgag aagatagtgg gcaacaccaa agtcctggag atacccttgg agcccaaaaa     1740

caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga     1800

gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg     1860

agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat     1920

cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag     1980

ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc     2040

caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac     2100

ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa     2160

caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg     2220

aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga     2280

tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta     2340

ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc     2400

ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc     2460

agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca     2520

gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca     2580

cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc     2640

ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga     2700

gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc     2760

cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca     2820

gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt     2880

attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga     2940

tgagctgata gacacacacc ttagctggat acaaaacata ttatgaaaca gaatgactgt     3000

gatctttgat ccgagaaatc aaagttaaag ttaatgaaat tatcaggaag gagttttcag     3060

gacctcctgc cagaaatcag acgtaaaaga agccattata gcaagacacc ttctgtatct     3120

gacccctcgg agccctccac agcccctcac cttctgtctc ctttcatgtt catctcccag     3180

cccggagtcc acacgcggat caatgtatgg gcactaagcg gactctcact taaggagctc     3240

gccacctccc tcta                                                       3254


<210>  125
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr 
            900                 905                 910         


His Leu Ser Trp Ile Gln Asn Ile Leu 
        915                 920     


<210>  126
<211>  4858
<212>  DNA
<213>  Homo sapiens

<400>  126
gcatcagaaa gctccgcagt tcttgagttc cacatgcaga gcagatgcga cagctagaag       60

tgagtagggc ccagaccctg gcccaggaag atccactaaa ggaggccatc cttccgcctt      120

cttctgcagg agtcaggatg gaaaggcaga tgtaaagtcc ctcatggcga aatataacac      180

ggggggcaac ccgacagagg atgtctcagt caatagccga cccttcagag tcacagggcc      240

aaactcatct tcaggaatac aagcaagaaa gaacttattc aacaaccaag gaaatgccag      300

ccctcctgca ggacccagca atgtacctaa gtttgggtcc ccaaagccac ctgtggcagt      360

caaaccttct tctgaggaaa agcctgacaa ggaacccaag cccccgtttc taaagcccac      420

tggagcaggc caaagattcg gaacaccagc cagcttgacc accagagacc ccgaggcgaa      480

agtgggattt ctgaaacctg taggccccaa gcccatcaac ttgcccaaag aagattccaa      540

acctacattt ccctggcctc ctggaaacaa gccatctctt cacagtgtaa accaagacca      600

tgacttaaag ccactaggcc cgaaatctgg gcctactcct ccaacctcag aaaatgaaca      660

gaagcaagcg tttcccaaat tgactggggt taaagggaaa tttatgtcag catcacaaga      720

tcttgaaccc aagcccctct tccccaaacc cgcctttggc cagaagccgc ccctaagtac      780

cgagaactcc catgaagacg aaagccccat gaagaatgtg tcttcatcaa aagggtcccc      840

agctcccctg ggagtcaggt ccaaaagcgg ccctttaaaa ccagcaaggg aagactcaga      900

aaataaagac catgcagggg agatttcaag tttgcccttt cctggagtgg ttttgaaacc      960

tgctgcgagc aggggaggcc caggtctctc caaaaatggt gaagaaaaaa aggaagatag     1020

gaagatagat gctgctaaga acaccttcca gagcaaaata aatcaggaag agttggcctc     1080

agggactcct cctgccaggt tccctaaggc cccttctaag ctgacagtgg gggggccatg     1140

gggccaaagt caggaaaagg aaaagggaga caagaattca gccaccccga aacagaagcc     1200

attgcctccc ttgtttacct tgggtccacc tccaccaaaa cccaacagac caccaaatgt     1260

tgacctgacg aaattccaca aaacctcttc tggaaacagt actagcaaag gccagacgtc     1320

ttactcaaca acttccctgc caccacctcc accatcccat ccggccagcc aaccaccatt     1380

gccagcatct cacccatcac aaccaccagt cccaagccta cctcccagaa acattaaacc     1440

tccgtttgac ctaaaaagcc ctgtcaatga agacaatcaa gatggtgtca cgcactctga     1500

tggtgctgga aatctagatg aggaacaaga cagtgaagga gaaacatatg aagacataga     1560

agcatccaaa gaaagagaga agaaaaggga aaaggaagaa aagaagaggt tagagctgga     1620

gaaaaaggaa cagaaagaga aagaaaagaa agaacaagaa ataaagaaga aatttaaact     1680

aacaggccct attcaagtca tccatcttgc aaaagcttgt tgtgatgtca aaggaggaaa     1740

gaatgaactg agcttcaagc aaggagagca aattgaaatc atccgcatca cagacaaccc     1800

agaaggaaaa tggttgggca gaacagcaag gggttcatat ggctatatta aaacaactgc     1860

tgtagagatt gactatgatt ctttgaaact gaaaaaagac tctcttggtg ccccttcaag     1920

acctattgaa gatgaccaag aagtatatga tgatgttgca gagcaggatg atattagcag     1980

ccacagtcag agtggaagtg gagggatatt ccctccacca ccagatgatg acatttatga     2040

tgggattgaa gaggaagatg ctgatgatgg ctccacacta caggttcaag agaagagtaa     2100

tacgtggtcc tgggggattt tgaagatgtt aaagggaaaa gatgacagaa agaaaagtat     2160

acgagagaaa cctaaagtct ctgactcaga caataatgaa ggttcatctt tccctgctcc     2220

tcctaaacaa ttggacatgg gagatgaagt ttacgatgat gtggatacct ctgatttccc     2280

tgtttcatca gcagagatga gtcaaggaac taatgttgga aaagctaaga cagaagaaaa     2340

ggaccttaag aagctaaaaa agcaggaaaa agaagaaaaa gacttcagga aaaaatttaa     2400

atatgatggt gaaattagag tcctatattc aactaaagtt acaacttcca taacttctaa     2460

aaagtgggga accagagatc tacaggtaaa acctggtgaa tctctagaag ttatacaaac     2520

cacagatgac acaaaagttc tctgcagaaa tgaagaaggg aaatatggtt atgtccttcg     2580

gagttaccta gcggacaatg atggagagat ctatgatgat attgctgatg gctgcatcta     2640

tgacaatgac tagcactcaa ctttggtcat tctgctgtgt tcattaggtg ccaatgtgaa     2700

gtctggattt taattggcat gttattgggt atcaagaaaa ttaatgcaca aaaccactta     2760

ttatcatttg ttatgaaatc ccaattatct ttacaaagtg tttaaagttt gaacatagaa     2820

aataatctct ctgcttaatt gttaactcag aagactacat tagtgagatg taagaattat     2880

taaatattcc atttccgctt tggctacaat tatgaagaag ttgaaggtac ttcttttaga     2940

ccaccagtaa ataatcctcc ttcaaaaaat aaaaataaaa gaaaaaggaa aatcattcag     3000

gaagaaatga cctgtctaaa aaaacctaag gaagaataat aatataagaa aggaaattta     3060

aaaacattcc acaagaagaa aaattattgt ttatacttct acttatggtt atatcttata     3120

ttctctattc aagtgacctg tcttttaaaa aggcagtgct gtcttacctc ttgctagtgg     3180

gttaaatgtt ttcaaaaatt atagcagtag tagaagtttt gtataaaatt tgtccttatt     3240

tgttaattgt atataaatgt taattatttg atacgaatgt tatgcattta gtatgcacat     3300

tgaagtctaa actgtagaag agtctaaaac aagttctctt tttgcagatt cacatactaa     3360

tggtttaatt ctgtgctctg tttaaagtac tattataact agagtagatc tgaatgagga     3420

taaccctaaa atcatgagga atggaagaat ggaccttgaa actacctagg cttttatgca     3480

tggcacctct ttataatgaa gacacttttt aaagtttttg tttttgtttc aattaccgct     3540

agattttttt ttctcttttt ttaaaatcca ttttactgga aagttggcca gcagagggag     3600

tagaaattat taaaattcta gtgtttggat tgggcccttc tctaacagta catactcatt     3660

cccaaagcaa tccaaaaaca aaatgtgaac catttgggtt tcaaatgtta agaacactaa     3720

atagcatgat ttaaaaaatg aaaaatgcta acacccaaga aaagaagata ttaagtgctt     3780

tttaacaact cctagagtac aaaatgagta catcataatg ctggctcttc tactaatgaa     3840

ccatcgagtg atattgaata aattatttat cttctcagtt tccttatctg taaattacaa     3900

tattagacta agtaagtttt tccaactctt cactaccaat taccttaggc ttttataatg     3960

ctccgcctac ttcagtccca tgtttcagaa gcttttgtct attttttaaa ctcattgatt     4020

aaataatgat taatgcattc tccacatttt aatattgcaa aggcccattg gagtttctga     4080

agtggctcca cagaattgaa ataatttcaa ataactgtaa aggaactgaa aatcttcaca     4140

gagatgaagt ggggtttcca ttaggtgctt tgaaatttga taacaaatca tcaacttcca     4200

ctggtcaata tatagatttt gggtgtctga ggccccaaga ttagatgcca ctaatctcca     4260

aagattccct ccaattatga aatattttaa tgtctacttt tagagagcac tagccagtat     4320

atgaccatgt gattaatttc ttttcacact agataaaatt acctggttca aaagtggttt     4380

ttgtttatta aatttggtaa taaatatata taatacacag acaggatagt ttttatgctg     4440

aagtttttgg ccagctttag tttgaggact ccttgataag cttgctaaac tttcagagtg     4500

ccctgagaca cttccagcca tccctcctcc tgccttcatt ggggcagact tgcattgcag     4560

tctgacagta attttttttc tgattgagaa ttatgtaaat tcagtacaat gtcagttttt     4620

aaaagtcaaa gttagatcaa gagaatattt cagagttttg gtttacacat caagaaacag     4680

acacacatac ctaggaaaga tttacacaat agataatcat cttaatgtga aagatatttg     4740

aagtattaat tttaatatat taaatatgat ttctgttata gtcttctgta tggaattttg     4800

tcacttaaga tgagctgcaa ataaataata ccttcaatgg ataaaaaaaa aaaaaaaa       4858


<210>  127
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ala Lys Tyr Asn Thr Gly Gly Asn Pro Thr Glu Asp Val Ser Val 
1               5                   10                  15      


Asn Ser Arg Pro Phe Arg Val Thr Gly Pro Asn Ser Ser Ser Gly Ile 
            20                  25                  30          


Gln Ala Arg Lys Asn Leu Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro 
        35                  40                  45              


Ala Gly Pro Ser Asn Val Pro Lys Phe Gly Ser Pro Lys Pro Pro Val 
    50                  55                  60                  


Ala Val Lys Pro Ser Ser Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro 
65                  70                  75                  80  


Pro Phe Leu Lys Pro Thr Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala 
                85                  90                  95      


Ser Leu Thr Thr Arg Asp Pro Glu Ala Lys Val Gly Phe Leu Lys Pro 
            100                 105                 110         


Val Gly Pro Lys Pro Ile Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr 
        115                 120                 125             


Phe Pro Trp Pro Pro Gly Asn Lys Pro Ser Leu His Ser Val Asn Gln 
    130                 135                 140                 


Asp His Asp Leu Lys Pro Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro 
145                 150                 155                 160 


Thr Ser Glu Asn Glu Gln Lys Gln Ala Phe Pro Lys Leu Thr Gly Val 
                165                 170                 175     


Lys Gly Lys Phe Met Ser Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu 
            180                 185                 190         


Phe Pro Lys Pro Ala Phe Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn 
        195                 200                 205             


Ser His Glu Asp Glu Ser Pro Met Lys Asn Val Ser Ser Ser Lys Gly 
    210                 215                 220                 


Ser Pro Ala Pro Leu Gly Val Arg Ser Lys Ser Gly Pro Leu Lys Pro 
225                 230                 235                 240 


Ala Arg Glu Asp Ser Glu Asn Lys Asp His Ala Gly Glu Ile Ser Ser 
                245                 250                 255     


Leu Pro Phe Pro Gly Val Val Leu Lys Pro Ala Ala Ser Arg Gly Gly 
            260                 265                 270         


Pro Gly Leu Ser Lys Asn Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile 
        275                 280                 285             


Asp Ala Ala Lys Asn Thr Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu 
    290                 295                 300                 


Ala Ser Gly Thr Pro Pro Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu 
305                 310                 315                 320 


Thr Val Gly Gly Pro Trp Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp 
                325                 330                 335     


Lys Asn Ser Ala Thr Pro Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr 
            340                 345                 350         


Leu Gly Pro Pro Pro Pro Lys Pro Asn Arg Pro Pro Asn Val Asp Leu 
        355                 360                 365             


Thr Lys Phe His Lys Thr Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln 
    370                 375                 380                 


Thr Ser Tyr Ser Thr Thr Ser Leu Pro Pro Pro Pro Pro Ser His Pro 
385                 390                 395                 400 


Ala Ser Gln Pro Pro Leu Pro Ala Ser His Pro Ser Gln Pro Pro Val 
                405                 410                 415     


Pro Ser Leu Pro Pro Arg Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser 
            420                 425                 430         


Pro Val Asn Glu Asp Asn Gln Asp Gly Val Thr His Ser Asp Gly Ala 
        435                 440                 445             


Gly Asn Leu Asp Glu Glu Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp 
    450                 455                 460                 


Ile Glu Ala Ser Lys Glu Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Glu Leu Glu Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys 
                485                 490                 495     


Glu Gln Glu Ile Lys Lys Lys Phe Lys Leu Thr Gly Pro Ile Gln Val 
            500                 505                 510         


Ile His Leu Ala Lys Ala Cys Cys Asp Val Lys Gly Gly Lys Asn Glu 
        515                 520                 525             


Leu Ser Phe Lys Gln Gly Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp 
    530                 535                 540                 


Asn Pro Glu Gly Lys Trp Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly 
545                 550                 555                 560 


Tyr Ile Lys Thr Thr Ala Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu 
                565                 570                 575     


Lys Lys Asp Ser Leu Gly Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln 
            580                 585                 590         


Glu Val Tyr Asp Asp Val Ala Glu Gln Asp Asp Ile Ser Ser His Ser 
        595                 600                 605             


Gln Ser Gly Ser Gly Gly Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile 
    610                 615                 620                 


Tyr Asp Gly Ile Glu Glu Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln 
625                 630                 635                 640 


Val Gln Glu Lys Ser Asn Thr Trp Ser Trp Gly Ile Leu Lys Met Leu 
                645                 650                 655     


Lys Gly Lys Asp Asp Arg Lys Lys Ser Ile Arg Glu Lys Pro Lys Val 
            660                 665                 670         


Ser Asp Ser Asp Asn Asn Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys 
        675                 680                 685             


Gln Leu Asp Met Gly Asp Glu Val Tyr Asp Asp Val Asp Thr Ser Asp 
    690                 695                 700                 


Phe Pro Val Ser Ser Ala Glu Met Ser Gln Gly Thr Asn Val Gly Lys 
705                 710                 715                 720 


Ala Lys Thr Glu Glu Lys Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys 
                725                 730                 735     


Glu Glu Lys Asp Phe Arg Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg 
            740                 745                 750         


Val Leu Tyr Ser Thr Lys Val Thr Thr Ser Ile Thr Ser Lys Lys Trp 
        755                 760                 765             


Gly Thr Arg Asp Leu Gln Val Lys Pro Gly Glu Ser Leu Glu Val Ile 
    770                 775                 780                 


Gln Thr Thr Asp Asp Thr Lys Val Leu Cys Arg Asn Glu Glu Gly Lys 
785                 790                 795                 800 


Tyr Gly Tyr Val Leu Arg Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile 
                805                 810                 815     


Tyr Asp Asp Ile Ala Asp Gly Cys Ile Tyr Asp Asn Asp 
            820                 825                 


<210>  128
<211>  5266
<212>  DNA
<213>  Homo sapiens

<400>  128
gcttaaaaat ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat       60

ggatttttta aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat      120

tgtactttgg ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt      180

gccgctggct catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt      240

gtaggagaca cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata      300

cttcagcagt tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg      360

gcttggttgg ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat      420

atgaagctag ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag      480

ccctttctca tagaggacga caagccttga aagctgttgg cctggaagat cagattgtat      540

cccaaggtat tcccatgaga gcaagaatga tccactctct ttcaggaaaa aagtctgcaa      600

ttccctatgg gacaaagtct cagtatattc tttctgtaag cagagaaaat ctaaacaagg      660

atctattgac tgctgctgag aaatacccca atgtgaaaat gcactttaac cacaggctgt      720

tgaaatgtaa tccagaggaa ggaatgatca cagtgcttgg atctgacaaa gttcccaaag      780

atgtcacttg tgacctcatt gtaggatgtg atggagccta ttcaactgtc agatctcacc      840

tgatgaagaa acctcgcttt gattacagtc agcagtacat tcctcatggg tacatggagt      900

tgactattcc acctaagaac ggagattatg ccatggaacc taattatctg catatttggc      960

ctagaaatac ctttatgatg attgcacttc ctaacatgaa caaatcattc acatgtactt     1020

tgttcatgcc ctttgaagag tttgaaaaac ttctaaccag taatgatgtg gtagatttct     1080

tccagaaata ctttccggat gccatccctc taattggaga gaaactccta gtgcaagatt     1140

tcttcctgtt gcctgcccag cccatgatat ctgtaaagtg ctcttcattt cactttaaat     1200

ctcactgtgt actgctggga gatgcagctc atgctatagt gccgtttttt gggcaaggaa     1260

tgaatgcggg ctttgaagac tgcttggtat ttgatgagtt aatggataaa ttcagtaacg     1320

accttagttt gtgtcttcct gtgttctcaa gattgagaat cccagatgat cacgcgattt     1380

cagacctatc catgtacaat tacatagaga tgcgagcaca tgtcaactca agctggttca     1440

tttttcagaa gaacatggag agatttcttc atgcgattat gccatcgacc tttatccctc     1500

tctatacaat ggtcactttt tccagaataa gataccatga ggctgtgcag cgttggcatt     1560

ggcaaaaaaa ggtgataaac aaaggactct ttttcttggg atcactgata gccatcagca     1620

gtacctacct acttatacac tacatgtcac cacgatcttt cctccgcttg agaagaccat     1680

ggaactggat agctcacttc cggaatacaa catgtttccc cgcaaaggcc gtggactccc     1740

tagaacaaat ttccaatctc attagcaggt gatagaaagg ttttgtggta gcaaatgcat     1800

gatttctctg tgaccaaaat taagcatgaa aaaaatgttt ccattgccat atttgattca     1860

ctagtggaag atagtgttct gcttataatt aaactgaatg tagagtatct ctgtatgtta     1920

attgcaatta ctggttgggg ggtgcatttt aaaagatgaa acatgcagct tccctacatt     1980

acacacactc aggttgagtc attctaacta taaaagtgca atgactaaga tccttcactt     2040

ctctgaaagt aaggccctag atgcctcagg gaagacagta atcatgcctt ttctttaaaa     2100

gacacaatag gactcgcaac agcattgact caacacctag gactaaaaat cacaacttaa     2160

ctagcatgtt aactgcactt ttcattacgt gaatggaact tacctaacca cagggctcag     2220

acttactaga taaaaccaga aatggaaata aggaattcag gggagttcca gagacttaca     2280

aaatgaactc attttatttt cccaccttca aatataagta ttatcatcta tctgtttatc     2340

gtctatctat ctatcatcta tctatctatc tatcatctat ctatctatct atctatctat     2400

ctatctatct atctatctct atttatttat gtatttagag atcaggtctc actctgttga     2460

ccaggctgga gtgcagtggt gagatctggg ttcactgcaa cctctgcctc ctgggctcaa     2520

gcaatcctcc cacttcagcc tcccaaatag ctggggctac catggtattt ttcagtagag     2580

accgggtctt gccatgctgc ccaggccagt ctcaaactcc tggcctcatg tgatctgccc     2640

acctcagcct cccaaagtac agggattaga gttgtgagcc accgctgcca gcccagagtt     2700

accctctaaa gataagaaaa aggctattaa tatcatacta agtgaaggac aggaaagggt     2760

tttattcata aattaaatgt ctacatgtgc cagaatggaa aggaaacaag gggagacaac     2820

ttttatagaa atacaaagcc attactttat tcaatttcag accctcagaa gcaatttact     2880

aatttattct tcgactacat actgcagcag aaccagcaat acacttgatt tttaaaagca     2940

catttagtga aatgttttct ttggttcatc cttctttaac aggctgctga gtcactcaga     3000

aatccttcaa acatgattaa ttatgaagat gaaacactag agtcatataa gaaataaaaa     3060

ttgggcaata aaataaaatg attcagtgtt tcttttctat attgtcaatg aaaaccttga     3120

gttctaataa tccatgttca gtttgtaggg aaagaaaaaa taatttttcc ttctacccac     3180

tttaggttcc ttggctgggg cccctataac aaaagacaga ttgacaagag aaaaacaaac     3240

ataaatttat tagcgggtat atgtaatata tatgtgggaa atacagggga atgagcaaat     3300

ctcaaagagc tggcgtctta gaactccctg gcttatatag catcgacaaa gaacagtaaa     3360

tttttagaga aacaacaaaa caaagaaaaa gagctttgag tctgtagggg cagcaatttg     3420

ggggaagcaa atatatggga gtttgccttg tagattcctc tggtgctggt ctccaggctg     3480

acaaggattc aaagttgtct ctgaaactcc tctttgtcat actgcacata taaaacgtct     3540

tttgtttcca acaagaggat tttctttttc attctagaat tatctccttg ataacttgat     3600

cagatatagg acatgacact gaatagagtc caacagtaca aaaaaaattc agtatgttct     3660

agctacttca cacatgtgta cgcgacagtt atttttacag taaggtattt tcgagaaaaa     3720

tgcattacgt gttttggaaa atagagtaat ttaaaaaata tatttgaaat gaaaatctcc     3780

aacacattag aagatgatga tgttagatgc ccatcgtgtg ccacaagtgg ttttttcatt     3840

atgtaaagca cccgttgaat taaaagaatt tgtttttgtt caacctcttc ctgaggccca     3900

agagcatatg ggcaattcgg atttcctgct ggaccacaag gttctgttga tattacatag     3960

aacgggtatt ccagacactt cttatgatga aagtccaaaa gtggcatcca atttaaggcc     4020

ccatctttcg ttgccattct tcattcctac aaaggacgaa cttggattac atcaactttg     4080

gacccattgg ttttgtcgct gtcgtcaact gacagtgatt catcactggt gatgataaaa     4140

atgatggaag aagagttgaa agtcactttt ttctttggcc tgtccccatc tttctgtgac     4200

atcacaatgg gtctgatctg catttcactt ccagctgctg gtaggtcttt agcaggcctc     4260

tggcacctca gcagtcggag gcacagaagc tgcaaaaggg atcttcgaaa ctgggcagag     4320

aaaaaataaa gtggaatatt aagtaaaagt tgggcactaa tctggattaa cattcgagga     4380

aatcagttga gctgaattta agttgttttt tgtttgttag caggtgtgga tgtggggtta     4440

tgtggtcatg ctcagatcta cctaaatcac cccagagctt tatgtctttt attcattcta     4500

attcttatta accggaatat gtaggaccat ttcaatacct tgtaatcctc caagcttcaa     4560

tctgcacaca ctttctatga gggcaggtac aactattaag agattttgaa cattaagtta     4620

gtccacaaat attcagtggg catctactag gtgacagcca ctgtgctata attagagact     4680

ttttactata agcatcaaaa acagataagg ctcttcctgg cagagtttac agcctggtgt     4740

acttgctaat gtctctttaa ttaggtgaag aatttttttt ttctatcgaa attactaatc     4800

agttggggaa aaaaatacta tagcagacag cactaatgtc atcaacaaac attgttcttc     4860

tccgtgtcct gggtacaaca tcgaataata tttcttggcc tcctttccgc ttctcctctc     4920

tgctgttcct ctctacaaga acctgggagg ccaacgccta aagatcataa tatcacacaa     4980

tggaaggaac ctagattcct aaatgactgc ataggacaga tcccatctcc tccacccaat     5040

acattattag actgaactgt gacctgaaat gagcaataaa ctctgtatta attcactgaa     5100

atgttggggt tgcttgttat agtagtcggt ccatcatgac cagtaaaaca taaatcaaaa     5160

gttaatgtaa ttgttatccc attatttaga gcgaaataaa tgttgaatat atggactttc     5220

tcagattagg aaataccaat taaaaatata ataaatagct acattg                    5266


<210>  129
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Asp Ser Ser Val Ile Gln Arg Lys Lys Val Ala Val Ile Gly Gly 
1               5                   10                  15      


Gly Leu Val Gly Ser Leu Gln Ala Cys Phe Leu Ala Lys Arg Asn Phe 
            20                  25                  30          


Gln Ile Asp Val Tyr Glu Ala Arg Glu Asp Thr Arg Val Ala Thr Phe 
        35                  40                  45              


Thr Arg Gly Arg Ser Ile Asn Leu Ala Leu Ser His Arg Gly Arg Gln 
    50                  55                  60                  


Ala Leu Lys Ala Val Gly Leu Glu Asp Gln Ile Val Ser Gln Gly Ile 
65                  70                  75                  80  


Pro Met Arg Ala Arg Met Ile His Ser Leu Ser Gly Lys Lys Ser Ala 
                85                  90                  95      


Ile Pro Tyr Gly Thr Lys Ser Gln Tyr Ile Leu Ser Val Ser Arg Glu 
            100                 105                 110         


Asn Leu Asn Lys Asp Leu Leu Thr Ala Ala Glu Lys Tyr Pro Asn Val 
        115                 120                 125             


Lys Met His Phe Asn His Arg Leu Leu Lys Cys Asn Pro Glu Glu Gly 
    130                 135                 140                 


Met Ile Thr Val Leu Gly Ser Asp Lys Val Pro Lys Asp Val Thr Cys 
145                 150                 155                 160 


Asp Leu Ile Val Gly Cys Asp Gly Ala Tyr Ser Thr Val Arg Ser His 
                165                 170                 175     


Leu Met Lys Lys Pro Arg Phe Asp Tyr Ser Gln Gln Tyr Ile Pro His 
            180                 185                 190         


Gly Tyr Met Glu Leu Thr Ile Pro Pro Lys Asn Gly Asp Tyr Ala Met 
        195                 200                 205             


Glu Pro Asn Tyr Leu His Ile Trp Pro Arg Asn Thr Phe Met Met Ile 
    210                 215                 220                 


Ala Leu Pro Asn Met Asn Lys Ser Phe Thr Cys Thr Leu Phe Met Pro 
225                 230                 235                 240 


Phe Glu Glu Phe Glu Lys Leu Leu Thr Ser Asn Asp Val Val Asp Phe 
                245                 250                 255     


Phe Gln Lys Tyr Phe Pro Asp Ala Ile Pro Leu Ile Gly Glu Lys Leu 
            260                 265                 270         


Leu Val Gln Asp Phe Phe Leu Leu Pro Ala Gln Pro Met Ile Ser Val 
        275                 280                 285             


Lys Cys Ser Ser Phe His Phe Lys Ser His Cys Val Leu Leu Gly Asp 
    290                 295                 300                 


Ala Ala His Ala Ile Val Pro Phe Phe Gly Gln Gly Met Asn Ala Gly 
305                 310                 315                 320 


Phe Glu Asp Cys Leu Val Phe Asp Glu Leu Met Asp Lys Phe Ser Asn 
                325                 330                 335     


Asp Leu Ser Leu Cys Leu Pro Val Phe Ser Arg Leu Arg Ile Pro Asp 
            340                 345                 350         


Asp His Ala Ile Ser Asp Leu Ser Met Tyr Asn Tyr Ile Glu Met Arg 
        355                 360                 365             


Ala His Val Asn Ser Ser Trp Phe Ile Phe Gln Lys Asn Met Glu Arg 
    370                 375                 380                 


Phe Leu His Ala Ile Met Pro Ser Thr Phe Ile Pro Leu Tyr Thr Met 
385                 390                 395                 400 


Val Thr Phe Ser Arg Ile Arg Tyr His Glu Ala Val Gln Arg Trp His 
                405                 410                 415     


Trp Gln Lys Lys Val Ile Asn Lys Gly Leu Phe Phe Leu Gly Ser Leu 
            420                 425                 430         


Ile Ala Ile Ser Ser Thr Tyr Leu Leu Ile His Tyr Met Ser Pro Arg 
        435                 440                 445             


Ser Phe Leu Arg Leu Arg Arg Pro Trp Asn Trp Ile Ala His Phe Arg 
    450                 455                 460                 


Asn Thr Thr Cys Phe Pro Ala Lys Ala Val Asp Ser Leu Glu Gln Ile 
465                 470                 475                 480 


Ser Asn Leu Ile Ser Arg 
                485     


<210>  130
<211>  3060
<212>  DNA
<213>  Homo sapiens

<400>  130
acacagagcc gcctttcagc cgcccgagaa ctgcccgccg cactccgcga ctgcggcgcc       60

tgctctcggg ccggggtctg cgcgcaccac gcggccggca gaaagggtaa gagaagggaa      120

ccccgctttg cagggctcca acttcggcgg acgcgttacg gcgagggcga aatgagtcgg      180

ccgtgaacgg tgtttcctgt tccgaatccc gagagccctg gaaagttttg aaggaggagg      240

catggcccgg cagccttatc gttttcccca ggcaaggatt ccggagagag gatcaggtgt      300

tttcaggtta accgtcagaa acgcaatggc acatcgtgat tctgagatga aagaagaatg      360

tctaagggaa gacctgaagt tttacttcat gagcccttgt gaaaaatacc gagccagacg      420

ccagattccg tggaaactgg gtttgcagat tttgaagata gtcatggtca ccacacagct      480

tgttcgtttt ggtttaagta accagctggt ggttgctttc aaagaagata acactgttgc      540

ttttaagcac ttgtttttga aaggatattc tggtacagat gaagatgact acagctgcag      600

tgtatatact caagaggatg cctatgagag catctttttt gctattaatc agtatcatca      660

gctaaaggac attaccctgg ggacccttgg ttatggagaa aatgaagaca atagaattgg      720

cttaaaagtc tgtaagcagc attacaagaa agggaccatg tttccttcta atgagacact      780

gaatattgac aacgacgttg agctcgattg tgttcaatta gaccttcagg acctctccaa      840

gaagcctccg gactggaaga actcatcatt cttcagactg gaattttatc ggctcttaca      900

ggttgaaatc tcctttcatc ttaaaggcat tgacctacag acaattcatt cccgtgagtt      960

accagactgt tatgtctttc agaatacgat tatctttgac aataaagctc acagtggcaa     1020

aatcaaaatc tattttgaca gtgatgccaa aattgaagaa tgtaaagact tgaacatatt     1080

tggatctact cagaaaaatg ctcagtatgt cctggtgttt gatgcatttg tcattgtgat     1140

ttgcttggca tctcttattc tgtgtacaag atccattgtt cttgctctaa ggttacggaa     1200

gagatttcta aatttcttcc tggagaagta caagcggcct gtgtgtgaca ccgaccagtg     1260

ggagttcatc aacggctggt atgtcctggt gattatcagc gacctaatga caatcattgg     1320

ctccatatta aaaatggaaa tcaaagcaaa gaatctcaca aactatgatc tctgcagcat     1380

ttttcttgga acctctacgc tcttggtttg ggttggagtc atcagatacc tgggttattt     1440

ccaggcatat aatgtgctga ttttaacaat gcaggcctca ctgccaaaag ttcttcggtt     1500

ttgtgcttgt gctggtatga tttatctggg ttacacattc tgtggctgga ttgtcttagg     1560

accataccat gacaagtttg aaaatctgaa cacagttgct gagtgtctgt tttctctggt     1620

caacggtgat gacatgtttg caacctttgc ccaaatccag cagaagagca tcttggtgtg     1680

gctgttcagt cgtctgtatt tatattcctt catcagcctt tttatatata tgattctcag     1740

tctttttatt gcacttatta cagattctta tgacaccatt aagaaattcc aacagaatgg     1800

gtttcctgaa acggatttgc aggaattcct gaaggaatgc agtagcaaag aagagtatca     1860

gaaagagtcc tcagccttcc tgtcctgcat ctgctgtcgg aggaggaaaa gaagtgatga     1920

tcacttgata cctattagct aaagttctgc taaagatgat taaagttcag gcatccttat     1980

ccagcggctg agcagaggaa ccccaaatga cttggacaag cagttccaaa atgactctct     2040

tatttaattg tggagtggga aagaggactc acagttagcc agctgaccat gactgaagtt     2100

ccagctttac tttttataaa cttgaatgat aaagaataga ccatgggcta ctactgggca     2160

ttagtgcaat ataacagcga taataaaatt ctctattagt ctgttaattt atgacatgat     2220

ctcggaatgg aaaaagatca tttcagagtg tgcgaaataa tagtctttaa ccatgtaatt     2280

aaatatgtgt gtttattgtc aaataaggat ttgttttaaa ggtgattctt gggtttgaag     2340

acatttgtta attcatggtc tgtacagaaa tgaagctggt tgcaatacca atctagagag     2400

tccaagctgg cgaactatta agctgtttaa agatcaccct tggcctggca cagtggttca     2460

cacctgtaat cccagcactt tgggaggcct aggcaggcag actgagctca ggagcttgag     2520

accagcctgg gcaacatggc aaaaacccac ctctacaaaa agtacaaaaa ttagtcgggc     2580

gtgatggcag gcatctgtag tcccagctac ttgggaagct gaagtgggag gatcacctga     2640

gctctggagg tggaggctgc catgagccat gatcgtgcca ctacactcca gcctgggtga     2700

cagagtgaga tcctgtctca aaaaaaaaaa aaaatcaccc ttaaatcaac aaaaagacct     2760

catgctcatg cagtggacat ttcttggcct gttttcctgt gggttttctt cagcatgata     2820

tgaagcaact gttggcatag ccagtgggat aaataagaaa tggaatcatt tggctgcctc     2880

gtcacttgtg ctaatggtca gttgtacaca catgacatgt ggaagtgacc tgtagcagcg     2940

gtcactcatt ttaacaattg aactctgctg ggttgggtat ttacctttgt ctagaaaaga     3000

aatatgatat attttctcta aataaattta ttttcatcat tccaaaaaaa aaaaaaaaaa     3060


<210>  131
<211>  566
<212>  PRT
<213>  homo sapiens

<400>  131

Met Ala Arg Gln Pro Tyr Arg Phe Pro Gln Ala Arg Ile Pro Glu Arg 
1               5                   10                  15      


Gly Ser Gly Val Phe Arg Leu Thr Val Arg Asn Ala Met Ala His Arg 
            20                  25                  30          


Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp Leu Lys Phe Tyr 
        35                  40                  45              


Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg Gln Ile Pro Trp 
    50                  55                  60                  


Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val Thr Thr Gln Leu 
65                  70                  75                  80  


Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala Phe Lys Glu Asp 
                85                  90                  95      


Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly Tyr Ser Gly Thr 
            100                 105                 110         


Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln Glu Asp Ala Tyr 
        115                 120                 125             


Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln Leu Lys Asp Ile 
    130                 135                 140                 


Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp Asn Arg Ile Gly 
145                 150                 155                 160 


Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr Met Phe Pro Ser 
                165                 170                 175     


Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu Asp Cys Val Gln 
            180                 185                 190         


Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp Trp Lys Asn Ser 
        195                 200                 205             


Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln Val Glu Ile Ser 
    210                 215                 220                 


Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His Ser Arg Glu Leu 
225                 230                 235                 240 


Pro Asp Cys Tyr Val Phe Gln Asn Thr Ile Ile Phe Asp Asn Lys Ala 
                245                 250                 255     


His Ser Gly Lys Ile Lys Ile Tyr Phe Asp Ser Asp Ala Lys Ile Glu 
            260                 265                 270         


Glu Cys Lys Asp Leu Asn Ile Phe Gly Ser Thr Gln Lys Asn Ala Gln 
        275                 280                 285             


Tyr Val Leu Val Phe Asp Ala Phe Val Ile Val Ile Cys Leu Ala Ser 
    290                 295                 300                 


Leu Ile Leu Cys Thr Arg Ser Ile Val Leu Ala Leu Arg Leu Arg Lys 
305                 310                 315                 320 


Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr Lys Arg Pro Val Cys Asp 
                325                 330                 335     


Thr Asp Gln Trp Glu Phe Ile Asn Gly Trp Tyr Val Leu Val Ile Ile 
            340                 345                 350         


Ser Asp Leu Met Thr Ile Ile Gly Ser Ile Leu Lys Met Glu Ile Lys 
        355                 360                 365             


Ala Lys Asn Leu Thr Asn Tyr Asp Leu Cys Ser Ile Phe Leu Gly Thr 
    370                 375                 380                 


Ser Thr Leu Leu Val Trp Val Gly Val Ile Arg Tyr Leu Gly Tyr Phe 
385                 390                 395                 400 


Gln Ala Tyr Asn Val Leu Ile Leu Thr Met Gln Ala Ser Leu Pro Lys 
                405                 410                 415     


Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr Leu Gly Tyr Thr 
            420                 425                 430         


Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys Phe Glu Asn 
        435                 440                 445             


Leu Asn Thr Val Ala Glu Cys Leu Phe Ser Leu Val Asn Gly Asp Asp 
    450                 455                 460                 


Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser Ile Leu Val Trp 
465                 470                 475                 480 


Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr 
                485                 490                 495     


Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Ser Tyr Asp Thr 
            500                 505                 510         


Ile Lys Lys Phe Gln Gln Asn Gly Phe Pro Glu Thr Asp Leu Gln Glu 
        515                 520                 525             


Phe Leu Lys Glu Cys Ser Ser Lys Glu Glu Tyr Gln Lys Glu Ser Ser 
    530                 535                 540                 


Ala Phe Leu Ser Cys Ile Cys Cys Arg Arg Arg Lys Arg Ser Asp Asp 
545                 550                 555                 560 


His Leu Ile Pro Ile Ser 
                565     


<210>  132
<211>  1687
<212>  DNA
<213>  homo sapiens

<400>  132
cgatcgaggc tgcagcgcgg ccgccgggcg cagcatgact gccgtcggcg tgcaggccca       60

gaggcctttg ggccaaaggc agccccgccg gtccttcttt gaatccttca tccggaccct      120

catcatcacg tgtgtggccc tggctgtggt cctgtcctcg gtctccattt gtgatgggca      180

ctggctcctg gctgaggacc gcctcttcgg gctctggcac ttctgcacca ccaccaacca      240

gacgatctgc ttcagagacc tgggccaggc ccatgtgccc gggctggccg tgggcatggg      300

cctggtacgc agcgtgggcg ccttggccgt ggtggccgcc atttttggcc tggagttcct      360

catggtgtcc cagttgtgcg aggacaaaca ctcacagtgc aagtgggtca tgggttccat      420

cctcctcctg gtgtctttcg tcctctcctc cggcgggctc ctgggttttg tgatcctcct      480

caggaaccaa gtcacactca tcggcttcac cctaatgttt tggtgcgaat tcactgcctc      540

cttcctcctc ttcctgaacg ccatcagcgg ccttcacatc aacagcatca cccatccctg      600

ggaatgaccg tggaaatttt aggccccctc cagggacatc agattccaca agaaaatatg      660

gtcaaaatgg gacttttcca gcatgtggcc tctggtgggg ctgggttgga caagggcctt      720

gaaacggctg cctgtttgcc gataacttgt gggtggtcag ccagaaatgg cccgggggcc      780

tctgcacctg gtctgcaggg ccagaggcca ggagggtgcc tcagtgccac caactgcaca      840

ggcttagcca gatgttgatt ttagaggaag aaaaaaacat tttaaaactc cttcttgaat      900

tttcttccct ggactggaat acagttggaa gcacaggggt aactggtacc tgagctagct      960

gcacagccaa ggatagttca tgcctgtttc attgacacgt gctgggatag gggctgcaga     1020

atccctgggg ctcccagggt tgttaagaat ggatcattct tccagctaag ggtccaatca     1080

gtgcctagga ctttcttcca ccagctcaaa gggccttcgt atgtatgtcc ctggcttcag     1140

ctttggtcat gccaaagagg cagagttcag gattccctca gaatgccctg cacacagtag     1200

gtttccaaac catttgactc ggtttgcctc cctgcccgtt gtttaaacct tacaaaccct     1260

ggataacccc atcttctagc agctggctgt gcctctggga gctctgccta tcagaaccct     1320

accttaaggt gggtttcctt ccgagaagag ttcttgagca agctctccca ggagggccca     1380

cctgactgct aatacacagc cctccccaag gcccgtgtgt gcatgtgtct gtcttttgtg     1440

agggttagac agcctcaggg caccattttt aatcccagaa cacatttcaa agagcacgta     1500

tctagacctg ctggactctg cagggggtga gggggaacag cgagagcttg ggtaatgatt     1560

aacacccatg ctggggatgc atggaggtga agggggccag gaaccagtgg agatttccat     1620

ccttgccagc acgtctgtac ttctgttcat taaagtgctc cctttctagt cctttttctg     1680

cccagaa                                                               1687


<210>  133
<211>  190
<212>  PRT
<213>  homo sapiens

<400>  133

Met Thr Ala Val Gly Val Gln Ala Gln Arg Pro Leu Gly Gln Arg Gln 
1               5                   10                  15      


Pro Arg Arg Ser Phe Phe Glu Ser Phe Ile Arg Thr Leu Ile Ile Thr 
            20                  25                  30          


Cys Val Ala Leu Ala Val Val Leu Ser Ser Val Ser Ile Cys Asp Gly 
        35                  40                  45              


His Trp Leu Leu Ala Glu Asp Arg Leu Phe Gly Leu Trp His Phe Cys 
    50                  55                  60                  


Thr Thr Thr Asn Gln Thr Ile Cys Phe Arg Asp Leu Gly Gln Ala His 
65                  70                  75                  80  


Val Pro Gly Leu Ala Val Gly Met Gly Leu Val Arg Ser Val Gly Ala 
                85                  90                  95      


Leu Ala Val Val Ala Ala Ile Phe Gly Leu Glu Phe Leu Met Val Ser 
            100                 105                 110         


Gln Leu Cys Glu Asp Lys His Ser Gln Cys Lys Trp Val Met Gly Ser 
        115                 120                 125             


Ile Leu Leu Leu Val Ser Phe Val Leu Ser Ser Gly Gly Leu Leu Gly 
    130                 135                 140                 


Phe Val Ile Leu Leu Arg Asn Gln Val Thr Leu Ile Gly Phe Thr Leu 
145                 150                 155                 160 


Met Phe Trp Cys Glu Phe Thr Ala Ser Phe Leu Leu Phe Leu Asn Ala 
                165                 170                 175     


Ile Ser Gly Leu His Ile Asn Ser Ile Thr His Pro Trp Glu 
            180                 185                 190 


<210>  134
<211>  5929
<212>  DNA
<213>  homo sapiens

<400>  134
tttcttttta aaaatcgctg ggtctgttga gctgtcctgg gctgggtgcc ttgctctttg       60

actgagactg gagacagacg gcaacagcca caggcagact gaggtggcaa taggaaatct      120

gccgagatgt tcagtcaggt gcccaggacc ccagcctcag gctgctacta cctaaattcc      180

atgacacctg agggccagga gatgtacttg cgatttgatc agactacaag acgctctcct      240

tacaggatga gccggattct agcacgccat cagctagtga ctaaaattca acaagaaatt      300

gaggcaaaag aagcatgtga ctggctccgt gctgccgggt tcccgcaata cgctcagtta      360

tatgaggatt cacaatttcc catcaacatt gtggctgtca agaatgatca tgattttctt      420

gaaaaggacc ttgtagaacc tctttgcaga cgactaaata cgttgaacaa gtgtgcctca      480

atgaaacttg atgtgaactt ccaaaggaaa aagggtgacg actccgatga ggaagatctt      540

tgtatcagca acaaatggac tttccaaaga accagtcgca ggtggtctcg tgtggacgac      600

ctctacacgc tgctccctcg aggagacaga aatgggtcac cgggaggcac ggggatgagg      660

aacacgacca gcagtgagag cgtcctcaca gacctgagcg agcctgaggt ctgctccatt      720

cacagcgaaa gcagtggagg cagcgacagt cgcagccagc cgggccagtg ctgtacagac      780

aacccggtca tgctggatgc cccactcgtc agcagcagcc tcccacagcc ccccagagat      840

gtcctcaacc accccttcca ccccaagaat gagaagccca cgagggctag ggccaaatca      900

tttttgaaac gcatggaaac actccgaggg aagggagccc acgggaggca taaggggtct      960

gggcggacag gtggcctggt gatcagtggg cccatgttgc agcaggagcc agagtccttt     1020

aaggctatgc agtgcatcca aataccaaat ggagatctcc agaattcgcc gccacctgcc     1080

tgcagaaaag ggctcccatg ctctggcaag tcgagtggcg agagcagccc gtcggagcac     1140

agcagcagcg gggtgagcac gccctgcctg aaggaacgca agtgccacga ggccaacaag     1200

cgcgggggca tgtacttgga ggacctagat gtgctggcgg ggacagcact gccggatgca     1260

ggggaccaaa gccgtatgca tgaatttcac tcccaagaga atttggtggt gcatattccc     1320

aaggatcaca aaccaggaac attccccaag gcactttcta ttgaaagcct ctctcccaca     1380

gatagtagca atggggttaa ttggaggacc ggtagcatct ccctgggcag agagcaggtc     1440

cctggtgcca gggagccccg gctcatggcg tcctgccaca gagccagccg agtcagtatc     1500

tatgacaatg tccctggctc ccatctgtat gccagcacag gagatctttt ggacttggag     1560

aaagatgacc ttttccctca cttggatgac attctgcagc atgtcaatgg gctccaagag     1620

gtagtcgatg actggtccaa agatgtcttg cctgaactgc aaactcatga tacattggtt     1680

ggggaacctg gcttatccac ctttccatct cctaatcaga tcaccttaga ttttgaaggt     1740

aactctgtct cagaaggtcg gacgacaccc agtgatgtgg aaagagatgt aacatctctt     1800

aatgaatctg agcctcctgg ggtcagagac aggagggatt ctggtgtagg ggcctctctg     1860

accaggccaa acaggcgact ccgatggaac agtttccagc tgtcgcacca gccccggccg     1920

gccccagcat cgccccacat cagcagccag acggccagcc agctgagcct gctccagcgc     1980

ttctcactgc tccgcctcac ggccatcatg gagaagcact ccatgtccaa caagcacggc     2040

tggacatggt cagttccaaa gttcatgaag aggatgaaag ttcccgacta caaagacaag     2100

gctgtctttg gcgttcctct catagtccac gtccaaagaa cgggacagcc cctgcctcaa     2160

agtattcagc aagcactgag atatctacgc agcaactgcc tcgatcaggt gggtcttttt     2220

cgcaaatcag gagtgaagtc tcgaatccat gcccttcgcc aaatgaatga aaacttccct     2280

gagaacgtca actatgaaga ccagtctgct tatgatgtgg cggatatggt gaaacagttc     2340

ttccgggacc tccctgagcc tcttttcacc aacaagctca gtgagacctt tctccatatc     2400

tatcagtatg tctccaaaga gcagcggctg caggccgtgc aggctgccat cctgctactg     2460

gccgatgaga acagggaggt cctgcagacg ctcttgtgtt tcctgaacga cgtcgtcaac     2520

ttggtggaag agaatcagat gacgcccatg aacctggcag tgtgtctggc cccctccctc     2580

tttcatctta atttattgaa gaaagaaagc tctccacgag tcatacagaa gaaatatgcc     2640

actgggaagc cagatcaaaa ggacctcaac gagaatctgg cagcagctca ggggctagcg     2700

cacatgatca tggaatgcga cagacttttt gaggttccac acgagttggt ggcccagtct     2760

cgtaactcgt atgtggaggc tgagatccac gtgccaaccc tggaagaatt ggggacacag     2820

ctggaggaga gtggggcaac tttccacact tacctgaacc atctcatcca gggcctccag     2880

aaagaagcca aggagaagtt caaaggatgg gtcacgtgct ccagcacgga caatacagat     2940

cttgctttca aaaaggtggg cgacgggaac ccgctgaagc tgtggaaggc ttctgtggag     3000

gtggaagcac ccccctcagt ggtcctgaac cgcgtgctga gagagcgcca cctgtgggac     3060

gaggactttg tgcagtggaa ggttgtggaa actctagaca ggcaaacaga gatctaccag     3120

tatgtgctga acagcatggc tccccatcct tccagagact ttgtggttct caggacctgg     3180

aaaactgatt tgcccaaagg aatgtgtacc ctggtgtccc tctccgtgga gcatgaggaa     3240

gcccagctcc tgggtggtgt gcgagcagtg gtgatggact cgcagtactt gatagaaccg     3300

tgtggctctg gcaagtcaag actgactcac atctgcagga tagacctgaa aggtcactcc     3360

ccagaatggt acagcaaagg ctttggacat ctgtgtgcag cagaagttgc caggattaga     3420

aactctttcc agcccctcat tgctgagggc ccagaaacta aaatctgagt tttgcccagt     3480

gtgacatcaa actcagggaa gaggaagcta aagtgacgag tgtggcagag agtgtgcatg     3540

tgagaaagcg agagaaagag gaactgaagg acgcggttaa tgcctaaaaa tggaaacgtt     3600

aagaagttgg aatgttggag atgcaagaat ttccaagaac tttcttagcc ttcctggaga     3660

tggctacatc cctactaata taattttaaa atgagaactt tatatatatt acttaaaatt     3720

aaatggacta ttccttgtgc attgcctaat ttgctattta aaggcttcta agaagcgtat     3780

acctaactgt aaataaatgt atgtatagca tatgtacata tgtgtgtata tctccatctt     3840

tactgtatat atgtaaaata ccaattttat atagaattgt gtgttttgaa aatgacggtg     3900

tctgactcag tgagtccctt cctcacacag ttctttccaa gtggctctgg gccccatctc     3960

tccactgtcc tgtaagctgt gcagaacctg ctgctaacac caaggtgtga acatgccctg     4020

atgcctaacc aaagatgagt taaccaaagg aaaataacat taaaggagac ttatgtgtta     4080

acgctttgtt tctgctattc aaaaactgag agtggagatc tgggataaag caaggaaata     4140

ataattactc ctccttaaag caaatggggg ggtgagaagt cattaccaaa tttaaagcta     4200

gatgaggagt tgccactggg cccagtaaga tggaatttca gtgagatatg gaccaccgga     4260

gtcagcgaga gtgactgaaa cagaagcgat acctctcgct cccatgccca tcactacaga     4320

ccccaagtca agatgaatat catagccttt acttcttcac agccaaaggg agcccctgtg     4380

ttgtctcaag tttttataaa tacatttcat aatgttatta aatgtcattc tatttgacca     4440

gtggcctatt tggtcacagt taattggtgt tttcttattg cactgaattc aactccagac     4500

accatacaaa gggagatgat ggccattccg ttcaaatcct agatcgttac agcttcaggg     4560

aattcatatt ttgttatgtg taggatactc ttaaaatgta attcattaaa cttttacaat     4620

ctgaaagaca gggtttttaa ctaacatgag accaaaacta tgttctttga ttagttttag     4680

atagtataat cgggtttatt aattcttctg tgtttcttca ctagccagtc caagctacct     4740

atgcatttga cccaacctta tttattattg tacagatgaa gcgaattgac tccctttagc     4800

caactgctaa tggatcgaat gtgcttttta ttgtaattca acagctatag agagaaagat     4860

aacttattgt gtgtttgatt tcagggagag agattttctt tggtcatcca taatagagat     4920

tgataagatt tagcaactgg tgttggagaa aaaaagaaaa gcaaatgagt gttttcaggt     4980

ttttttgcat tatatgcatt tatgtaatgt ttctgttatc agcaatgtgc aattatttta     5040

ttgagaggaa taaaaaagct ttctatgagt ttggtatggt gcgaggaaaa tcttacagtt     5100

tgaattatga cctagaaatt tttcattccc atatctacct aagaaggaag cagtaaatcc     5160

ataatttacc ttttgggcaa tgctttgtga gcaaaacaaa gtcacttctg ccataacatc     5220

ttgaatttaa ccatatatgc cagattactt tatatgcatc aacaagatca ccagtgaagt     5280

ttaatctagc taaacactgg tcctgctcct gagatgggat cctatgtgtt tggaaaacgt     5340

gataggcaca cgaggatgag tggctttgta tcgcccagag aggtgcttgt ccagatttca     5400

catgcacatg aattgcctgg ggatcttgtg aaactgcaga ctctgctcca agtaatctgg     5460

gctgggcctg agattctgca tttctaagga gtctcaggga tgcctatgct gctggcctaa     5520

aaccacactc agaaacgagg acctagaaga tccctaaaac agaataagaa caaatgtgat     5580

tgtatttctg attctccctc tcttcgaatt atctgacttt tttgtttttg tgcacatagt     5640

aatcatatca ccgctgcata acaacacagt gcatcttttt aaaacaagga aaagggaaaa     5700

aaaggagaaa aaacgatgca tcaagcttgt ttgtcaaata ccacagtatt ttattcattg     5760

ttatcttgcc aatggaaata aagtatgata ttgcatttaa atattatatt tatacctcat     5820

gtatattttt acctcaattg ttgatatcaa tcatcaattg taaataaata attgccaagg     5880

caaataaatt tatatatatt aaatatttcc tattttctat aaaataaaa                 5929


<210>  135
<211>  1113
<212>  PRT
<213>  homo sapiens

<400>  135

Met Phe Ser Gln Val Pro Arg Thr Pro Ala Ser Gly Cys Tyr Tyr Leu 
1               5                   10                  15      


Asn Ser Met Thr Pro Glu Gly Gln Glu Met Tyr Leu Arg Phe Asp Gln 
            20                  25                  30          


Thr Thr Arg Arg Ser Pro Tyr Arg Met Ser Arg Ile Leu Ala Arg His 
        35                  40                  45              


Gln Leu Val Thr Lys Ile Gln Gln Glu Ile Glu Ala Lys Glu Ala Cys 
    50                  55                  60                  


Asp Trp Leu Arg Ala Ala Gly Phe Pro Gln Tyr Ala Gln Leu Tyr Glu 
65                  70                  75                  80  


Asp Ser Gln Phe Pro Ile Asn Ile Val Ala Val Lys Asn Asp His Asp 
                85                  90                  95      


Phe Leu Glu Lys Asp Leu Val Glu Pro Leu Cys Arg Arg Leu Asn Thr 
            100                 105                 110         


Leu Asn Lys Cys Ala Ser Met Lys Leu Asp Val Asn Phe Gln Arg Lys 
        115                 120                 125             


Lys Gly Asp Asp Ser Asp Glu Glu Asp Leu Cys Ile Ser Asn Lys Trp 
    130                 135                 140                 


Thr Phe Gln Arg Thr Ser Arg Arg Trp Ser Arg Val Asp Asp Leu Tyr 
145                 150                 155                 160 


Thr Leu Leu Pro Arg Gly Asp Arg Asn Gly Ser Pro Gly Gly Thr Gly 
                165                 170                 175     


Met Arg Asn Thr Thr Ser Ser Glu Ser Val Leu Thr Asp Leu Ser Glu 
            180                 185                 190         


Pro Glu Val Cys Ser Ile His Ser Glu Ser Ser Gly Gly Ser Asp Ser 
        195                 200                 205             


Arg Ser Gln Pro Gly Gln Cys Cys Thr Asp Asn Pro Val Met Leu Asp 
    210                 215                 220                 


Ala Pro Leu Val Ser Ser Ser Leu Pro Gln Pro Pro Arg Asp Val Leu 
225                 230                 235                 240 


Asn His Pro Phe His Pro Lys Asn Glu Lys Pro Thr Arg Ala Arg Ala 
                245                 250                 255     


Lys Ser Phe Leu Lys Arg Met Glu Thr Leu Arg Gly Lys Gly Ala His 
            260                 265                 270         


Gly Arg His Lys Gly Ser Gly Arg Thr Gly Gly Leu Val Ile Ser Gly 
        275                 280                 285             


Pro Met Leu Gln Gln Glu Pro Glu Ser Phe Lys Ala Met Gln Cys Ile 
    290                 295                 300                 


Gln Ile Pro Asn Gly Asp Leu Gln Asn Ser Pro Pro Pro Ala Cys Arg 
305                 310                 315                 320 


Lys Gly Leu Pro Cys Ser Gly Lys Ser Ser Gly Glu Ser Ser Pro Ser 
                325                 330                 335     


Glu His Ser Ser Ser Gly Val Ser Thr Pro Cys Leu Lys Glu Arg Lys 
            340                 345                 350         


Cys His Glu Ala Asn Lys Arg Gly Gly Met Tyr Leu Glu Asp Leu Asp 
        355                 360                 365             


Val Leu Ala Gly Thr Ala Leu Pro Asp Ala Gly Asp Gln Ser Arg Met 
    370                 375                 380                 


His Glu Phe His Ser Gln Glu Asn Leu Val Val His Ile Pro Lys Asp 
385                 390                 395                 400 


His Lys Pro Gly Thr Phe Pro Lys Ala Leu Ser Ile Glu Ser Leu Ser 
                405                 410                 415     


Pro Thr Asp Ser Ser Asn Gly Val Asn Trp Arg Thr Gly Ser Ile Ser 
            420                 425                 430         


Leu Gly Arg Glu Gln Val Pro Gly Ala Arg Glu Pro Arg Leu Met Ala 
        435                 440                 445             


Ser Cys His Arg Ala Ser Arg Val Ser Ile Tyr Asp Asn Val Pro Gly 
    450                 455                 460                 


Ser His Leu Tyr Ala Ser Thr Gly Asp Leu Leu Asp Leu Glu Lys Asp 
465                 470                 475                 480 


Asp Leu Phe Pro His Leu Asp Asp Ile Leu Gln His Val Asn Gly Leu 
                485                 490                 495     


Gln Glu Val Val Asp Asp Trp Ser Lys Asp Val Leu Pro Glu Leu Gln 
            500                 505                 510         


Thr His Asp Thr Leu Val Gly Glu Pro Gly Leu Ser Thr Phe Pro Ser 
        515                 520                 525             


Pro Asn Gln Ile Thr Leu Asp Phe Glu Gly Asn Ser Val Ser Glu Gly 
    530                 535                 540                 


Arg Thr Thr Pro Ser Asp Val Glu Arg Asp Val Thr Ser Leu Asn Glu 
545                 550                 555                 560 


Ser Glu Pro Pro Gly Val Arg Asp Arg Arg Asp Ser Gly Val Gly Ala 
                565                 570                 575     


Ser Leu Thr Arg Pro Asn Arg Arg Leu Arg Trp Asn Ser Phe Gln Leu 
            580                 585                 590         


Ser His Gln Pro Arg Pro Ala Pro Ala Ser Pro His Ile Ser Ser Gln 
        595                 600                 605             


Thr Ala Ser Gln Leu Ser Leu Leu Gln Arg Phe Ser Leu Leu Arg Leu 
    610                 615                 620                 


Thr Ala Ile Met Glu Lys His Ser Met Ser Asn Lys His Gly Trp Thr 
625                 630                 635                 640 


Trp Ser Val Pro Lys Phe Met Lys Arg Met Lys Val Pro Asp Tyr Lys 
                645                 650                 655     


Asp Lys Ala Val Phe Gly Val Pro Leu Ile Val His Val Gln Arg Thr 
            660                 665                 670         


Gly Gln Pro Leu Pro Gln Ser Ile Gln Gln Ala Leu Arg Tyr Leu Arg 
        675                 680                 685             


Ser Asn Cys Leu Asp Gln Val Gly Leu Phe Arg Lys Ser Gly Val Lys 
    690                 695                 700                 


Ser Arg Ile His Ala Leu Arg Gln Met Asn Glu Asn Phe Pro Glu Asn 
705                 710                 715                 720 


Val Asn Tyr Glu Asp Gln Ser Ala Tyr Asp Val Ala Asp Met Val Lys 
                725                 730                 735     


Gln Phe Phe Arg Asp Leu Pro Glu Pro Leu Phe Thr Asn Lys Leu Ser 
            740                 745                 750         


Glu Thr Phe Leu His Ile Tyr Gln Tyr Val Ser Lys Glu Gln Arg Leu 
        755                 760                 765             


Gln Ala Val Gln Ala Ala Ile Leu Leu Leu Ala Asp Glu Asn Arg Glu 
    770                 775                 780                 


Val Leu Gln Thr Leu Leu Cys Phe Leu Asn Asp Val Val Asn Leu Val 
785                 790                 795                 800 


Glu Glu Asn Gln Met Thr Pro Met Asn Leu Ala Val Cys Leu Ala Pro 
                805                 810                 815     


Ser Leu Phe His Leu Asn Leu Leu Lys Lys Glu Ser Ser Pro Arg Val 
            820                 825                 830         


Ile Gln Lys Lys Tyr Ala Thr Gly Lys Pro Asp Gln Lys Asp Leu Asn 
        835                 840                 845             


Glu Asn Leu Ala Ala Ala Gln Gly Leu Ala His Met Ile Met Glu Cys 
    850                 855                 860                 


Asp Arg Leu Phe Glu Val Pro His Glu Leu Val Ala Gln Ser Arg Asn 
865                 870                 875                 880 


Ser Tyr Val Glu Ala Glu Ile His Val Pro Thr Leu Glu Glu Leu Gly 
                885                 890                 895     


Thr Gln Leu Glu Glu Ser Gly Ala Thr Phe His Thr Tyr Leu Asn His 
            900                 905                 910         


Leu Ile Gln Gly Leu Gln Lys Glu Ala Lys Glu Lys Phe Lys Gly Trp 
        915                 920                 925             


Val Thr Cys Ser Ser Thr Asp Asn Thr Asp Leu Ala Phe Lys Lys Val 
    930                 935                 940                 


Gly Asp Gly Asn Pro Leu Lys Leu Trp Lys Ala Ser Val Glu Val Glu 
945                 950                 955                 960 


Ala Pro Pro Ser Val Val Leu Asn Arg Val Leu Arg Glu Arg His Leu 
                965                 970                 975     


Trp Asp Glu Asp Phe Val Gln Trp Lys Val Val Glu Thr Leu Asp Arg 
            980                 985                 990         


Gln Thr Glu Ile Tyr Gln Tyr Val  Leu Asn Ser Met Ala  Pro His Pro 
        995                 1000                 1005             


Ser Arg  Asp Phe Val Val Leu  Arg Thr Trp Lys Thr  Asp Leu Pro 
    1010                 1015                 1020             


Lys Gly  Met Cys Thr Leu Val  Ser Leu Ser Val Glu  His Glu Glu 
    1025                 1030                 1035             


Ala Gln  Leu Leu Gly Gly Val  Arg Ala Val Val Met  Asp Ser Gln 
    1040                 1045                 1050             


Tyr Leu  Ile Glu Pro Cys Gly  Ser Gly Lys Ser Arg  Leu Thr His 
    1055                 1060                 1065             


Ile Cys  Arg Ile Asp Leu Lys  Gly His Ser Pro Glu  Trp Tyr Ser 
    1070                 1075                 1080             


Lys Gly  Phe Gly His Leu Cys  Ala Ala Glu Val Ala  Arg Ile Arg 
    1085                 1090                 1095             


Asn Ser  Phe Gln Pro Leu Ile  Ala Glu Gly Pro Glu  Thr Lys Ile 
    1100                 1105                 1110             


<210>  136
<211>  2757
<212>  DNA
<213>  homo sapiens

<400>  136
gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt       60

cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga      120

agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga      180

atttttcttc agcaagctgt gaaactaaat ccacaacctt tggagaccca ggaacaccct      240

ccaatctctg tgtgttttgt aaacatcact ggagggtctt ctacgtgagc aattggattg      300

tcatcagccc tgcctgtttt gcacctggga agtgccctgg tcttacttgg gtccaaattg      360

ttggctttca cttttgaccc taagcatctg aagccatggg ccacacacgg aggcagggaa      420

catcaccatc caagtgtcca tacctcaatt tctttcagct cttggtgctg gctggtcttt      480

ctcacttctg ttcaggtgtt atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt      540

cctgtggtca caatgtttct gttgaagagc tggcacaaac tcgcatctac tggcaaaagg      600

agaagaaaat ggtgctgact atgatgtctg gggacatgaa tatatggccc gagtacaaga      660

accggaccat ctttgatatc actaataacc tctccattgt gatcctggct ctgcgcccat      720

ctgacgaggg cacatacgag tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg      780

aacacctggc tgaagtgacg ttatcagtca aagctgactt ccctacacct agtatatctg      840

actttgaaat tccaacttct aatattagaa ggataatttg ctcaacctct ggaggttttc      900

cagagcctca cctctcctgg ttggaaaatg gagaagaatt aaatgccatc aacacaacag      960

tttcccaaga tcctgaaact gagctctatg ctgttagcag caaactggat ttcaatatga     1020

caaccaacca cagcttcatg tgtctcatca agtatggaca tttaagagtg aatcagacct     1080

tcaactggaa tacaaccaag caagagcatt ttcctgataa cctgctccca tcctgggcca     1140

ttaccttaat ctcagtaaat ggaatttttg tgatatgctg cctgacctac tgctttgccc     1200

caagatgcag agagagaagg aggaatgaga gattgagaag ggaaagtgta cgccctgtat     1260

aacagtgtcc gcagaagcaa ggggctgaaa agatctgaag gtcccacctc catttgcaat     1320

tgacctcttc tgggaacttc ctcagatgga caagattacc ccaccttgcc ctttacgtat     1380

ctgctcttag gtgcttcttc acttcagttg ctttgcagga agtgtctaga ggaatatggt     1440

gggcacagaa gtagctctgg tgaccttgat caaggtgttt tgaaatgcag aattcttgag     1500

ttctggaagg gactttagag aataccagtg ttattaatga caaaggcact gaggcccagg     1560

gaggtgaccc gaattataaa ggccagcgcc agaacccaga tttcctaact ctggtgctct     1620

ttccctttat cagtttgact gtggcctgtt aactggtata tacatatata tgtcaggcaa     1680

agtgctgctg gaagtagaat ttgtccaata acaggtcaac ttcagagact atctgatttc     1740

ctaatgtcag agtagaagat tttatgctgc tgtttacaaa agcccaatgt aatgcatagg     1800

aagtatggca tgaacatctt taggagacta atggaaatat tattggtgtt tacccagtat     1860

tccatttttt tcattgtgtt ctctattgct gctctctcac tcccccatga ggtacagcag     1920

aaaggagaac tatccaaaac taatttcctc tgacatgtaa gacgaatgat ttaggtacgt     1980

caaagcagta gtcaaggagg aaagggatag tccaaagact taactggttc atattggact     2040

gataatctct ttaaatggct ttatgctagt ttgacctcat ttgtaaaata tttatgagaa     2100

agttctcatt taaaatgaga tcgttgttta cagtgtatgt actaagcagt aagctatctt     2160

caaatgtcta aggtagtaac tttccatagg gcctccttag atccctaaga tggctttttc     2220

tccttggtat ttctgggtct ttctgacatc agcagagaac tggaaagaca tagccaactg     2280

ctgttcatgt tactcatgac tcctttctct aaaactgcct tccacaattc actagaccag     2340

aagtggacgc aacttaagct gggataatca cattatcatc tgaaaatctg gagttgaaca     2400

gcaaaagaag acaacatttc tcaaatgcac atctcatggc agctaagcca catggctggg     2460

atttaaagcc tttagagcca gcccatggct ttagctacct cactatgctg cttcacaaac     2520

cttgctcctg tgtaaaacta tattctcagt gtagggcaga gaggtctaac accaacataa     2580

ggtactagca gtgtttcccg tattgacagg aatacttaac tcaataattc ttttcttttc     2640

catttagtaa cagttgtgat gactatgttt ctattctaag taattcctgt attctacagc     2700

agatactttg tcagcaatac taagggaaga aacaaagttg aaccgtttct ttaataa        2757


<210>  137
<211>  288
<212>  PRT
<213>  homo sapiens

<400>  137

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  138
<211>  139
<212>  PRT
<213>  homo sapiens

<400>  138

Met Ala Ala Gly Ser Ser Gly Ala Ser Met Gly Trp Arg Gly Ser Pro 
1               5                   10                  15      


Gly Arg Pro Ser Gly Arg Ser Gln His Cys Pro Arg Thr Ser Ser Ala 
            20                  25                  30          


Cys Ala Arg Trp Ala Arg Tyr Arg Gly Ser Phe Gln Gly Phe Tyr Pro 
        35                  40                  45              


Asn Ser Thr Tyr Phe Tyr Leu Phe Ser Leu Glu Leu Phe Cys Leu Tyr 
    50                  55                  60                  


Leu Ser Phe Ile Cys Lys Asn Ser Ile Arg Lys Ile His Arg Val Asn 
65                  70                  75                  80  


Ala His Gln Ala Tyr Arg Arg Ser Gly Arg Asn Met Phe Ser Pro Ala 
                85                  90                  95      


His Phe Gln Ser Val Phe Glu His Arg Gly Phe His Gly Phe Asp Ser 
            100                 105                 110         


Phe His Lys Arg Leu Val Leu Ser Val Phe Thr Ile Tyr Val Ser Glu 
        115                 120                 125             


Thr Ile Asn Tyr Ile Ile Phe Met Phe Thr His 
    130                 135                 


<210>  139
<211>  7948
<212>  DNA
<213>  homo sapiens

<400>  139
agatgcacag tggagctcgc tacccctcct ctcctccaaa aatctcatca gacgatatcc       60

cagacaggag cggttagaga gagaggaatc acatctccac acagttttag ggtgcttttt      120

atttttacaa atcttcttgt gtgttttttg ccttgatcca tcctcttccc gccgagatcg      180

tatggcgcct ttctctcgat tatgaatttg atcaatccat ctttggaaga aaacccacat      240

agttttttca ggagctgaaa attgagtcgt tatagaaata ttaggacata ttttcaatca      300

tttcggtgcc cgaagggagg caagagctca gttttatatt gagacattac gccggctgaa      360

ggcagagaat gcgtttccct gccaggacct gatgcaatcc attcaagcca acaagtttgg      420

agagaatgtt gagttcaatc aattcagaac gtcgagatgg agcccaactc actccagtgg      480

gtcggctcac cgtgtggctt gcacggacct tacattttct acaaggcttt tcaattccac      540

cttgaaggca aaccaagaat tttgtccctt ggcgactttt tctttgtaag atgtacgcca      600

aaggatccga tttgcatagc ggagctccag ctgttgtggg aagagaggac cagccggcaa      660

cttttatcca gctctaaact ttatttcctc ccagaagaca ctccccaggg cagaaatagc      720

gaccatggcg aggatgaagt cattgctgtt tccgaaaagg tgattgtgaa gcttgaagac      780

ctggtcaagt gggtacattc tgatttctcc aagtggagat gtggcttcca cgctggacca      840

gtgaaaactg aggccttggg aaggaatgga cagaaggaag ctctgctgaa gtacaggcag      900

tcaaccctaa acagtggact caacttcaaa gacgttctca aggagaaggc agacctgggg      960

gaggacgagg aagaaacgaa cgtgatagtt ctcagctacc cccagtactg ccggtaccgc     1020

tcgatgctga aacgcatcca ggataagcca tcttccattc taacggacca gtttgcattg     1080

gccctggggg gcattgcagt ggtcagcagg aaccctcaga tcctgtactg tcgggacacc     1140

tttgaccacc cgactctcat agaaaacgag agtatatgcg atgagtttgc gccaaatctt     1200

aaaggcagac cacgcaaaaa gaaaccatgc ccacaaagaa gagattcatt cagtggtgtt     1260

aaggattcca acaacaattc cgatggcaaa gccgttgcca aggtgaaatg tgaggccagg     1320

tcagccttga ccaagccgaa gaataaccat aactgtaaaa aagtctcaaa tgaagaaaaa     1380

ccaaaggttg ccattggtga agagtgcagg gcagatgaac aagccttctt ggtggcactt     1440

tataaataca tgaaagaaag gaaaacgccg atagaacgaa taccctattt aggttttaaa     1500

cagattaacc tttggactat gtttcaagct gctcaaaaac tgggaggata tgaaacaata     1560

acagcccgcc gtcagtggaa acatatttat gatgaattag gcggtaatcc tgggagcacc     1620

agcgctgcca cttgtacccg cagacattat gaaagattaa tcctaccata tgaaagattt     1680

attaaaggag aagaagataa gcccctgcct ccaatcaaac ctcggaaaca ggagaacagt     1740

tcacaggaaa atgagaacaa aacaaaagta tctggaacca aacgcatcaa acatgaaata     1800

cctaaaagca agaaagaaaa agaaaatgcc ccaaagcccc aggatgcagc agaggtttca     1860

tcagagcaag aaaaagaaca agagacttta ataagccaga aaagcatccc tgagcctctc     1920

ccagcagcag acatgaagaa aaaaatagaa gggtatcagg aattttcagc gaagcccctg     1980

gcatccagag tagacccaga gaaggacaac gaaacagacc aaggttccaa cagtgagaag     2040

gtggcagagg aggcgggaga gaaggggccc acacctccac tcccaagtgc tcctctggcc     2100

ccagaaaaag attcagcctt ggtccctggg gccagcaaac agccactcac ctctcctagt     2160

gccctggtgg actcaaaaca agaatccaaa ctgtgctgtt ttacagagag ccctgaaagt     2220

gaaccccaag aagcatcctt ccccagcttc cccaccacac agccaccgct ggcaaaccag     2280

aatgagacgg aggatgacaa actgcccgcc atggcagatt acattgccaa ctgcaccgtg     2340

aaggtggacc agctgggcag tgacgacatc cacaatgcgc tcaagcagac cccaaaggtc     2400

cttgtggtcc agtcgtttga catgttcaaa gacaaagacc tgactgggcc catgaacgag     2460

aaccatggac ttaattacac gcccctgctc tactctaggg gcaacccagg catcatgtcc     2520

ccactggcca agaaaaagct tttgtcccaa gtgagtgggg ccagcctctc cagcagctac     2580

ccttatggct ccccaccccc tttgatcagc aaaaagaaac tgattgctag ggatgacttg     2640

tgttccagtt tgtcccagac ccaccatggc caaagcactg accatatggc ggtcagccgg     2700

ccatcagtga ttcagcacgt ccagagtttc agaagcaagc cctcggaaga gagaaagacc     2760

atcaatgaca tctttaagca tgagaaactg agtcgatcag atccccaccg ctgcagcttc     2820

tccaagcatc accttaaccc ccttgctgac tcctacgtcc tgaagcaaga aattcaggag     2880

ggcaaggata aactcttaga gaaaagggcc ctcccccatt cccacatgcc tagcttcctg     2940

gctgacttct actcgtcccc tcatctccat agcctctaca gacacaccga gcaccatctt     3000

cataatgaac agacatccaa atacccttcc agggacatgt acagggaatc ggaaaacagt     3060

tcttttcctt cccacagaca ccaagaaaag ctccatgtaa attatctcac gtccctgcac     3120

ctgcaagaca aaaagtcggc ggcagcagaa gcccctacgg atgatcagcc tacagatctg     3180

agccttccca agaacccgca caaacctacc ggcaaggtcc tgggcctggc tcattccacc     3240

acagggcccc aggagagcaa aggcatctcc cagttccagg tcttaggcag ccagagtcga     3300

gactgtcacc ccaaagcctg tcgggtatca cccatgacca tgtcaggccc taaaaaatac     3360

cctgaatcgc tttcaagatc aggaaaacct caccatgtga gactggagaa tttcaggaag     3420

atggaaggca tggtccaccc aatcctgcac cggaaaatga gcccgcagaa cattggggcg     3480

gcgcggccga tcaagcgcag cctggaggat ttggaccttg tgattgcagg gaaaaaggcc     3540

cgggcagtgt ctcccttaga cccatccaag gaggtctctg ggaaggagaa ggcctctgag     3600

caggagagtg aaggcagcaa agcagcgcac ggtgggcatt ccgggggcgg atcagaaggc     3660

cacaagcttc ccctctcctc ccctatcttc ccaggtctgt attccgggag cctgtgtaac     3720

tcgggcctca actccaggct cccggctggg tattctcatt ctctgcagta cttgaaaaac     3780

cagactgtgc tttctccact catgcagccc ctggctttcc actcgcttgt gatgcaaaga     3840

ggaattttta catcaccgac aaattctcag cagctgtaca gacacttggc tgcggctaca     3900

cctgtaggaa gttcatatgg ggaccttttg cataacagca tttacccttt agctgctata     3960

aatcctcaag ctgcctttcc atcttcccag ctgtcatccg tgcaccccag tacaaaactg     4020

taggctcagc tctgcccagc agtccaaagc ggcatggcca acagagcttc actccttacc     4080

caggagtgct ggcttataga gttagaagtc agtatttctt ctaatctgag gctatgatca     4140

gtcccagctg taggggccca gaggggaggt gaacatgcct gatttttgtg ggacaactct     4200

agcccacaaa ctgactggct ggtgagtctt gactcccttc caacacagat gcccaggcac     4260

ctccagatca ttcacttcgc acgtgggcct tgtgaaggga tttgtgaata tccaggaaga     4320

acttagagga ccccatctga gttcggatgg tcaggaaaca atctgggcaa aaaagaggca     4380

ggcatttcaa aggaaggggc aaggaagact ggcaaacaga tggcaaggga tgcccctctt     4440

tttcataaaa ctctccaagg ttcaatcaat gcaatgtata gtgaaacttc aatagatctt     4500

tcattttgac actattaaac aatccagaga agtaaacact gttaaattga ctgtatatat     4560

ttgcttctta aaactacctg tatcactgtt tgctcaccta atttatatac aggtagttcc     4620

attttctccc agttccttct cgtctttttt tttttttttt tttttttttt tattaaatgg     4680

tattgctttt gtttgcaggt ctttttgttt ttgttttgtt tttgaggctg actgactgtc     4740

ctagttgttg tgtgtttgta atttttccac atcttatttt gagcagcttt gggtggtaaa     4800

gttattgttt acaaattgaa gcaactgatt ctagtggaac aaatgaaaaa gaaacagtca     4860

agcacacaat agtgcaaaga acgttccttt gtagatccgc aacttaagga ttttgttcct     4920

cataaatggc atagttgaaa gagcttatac actgcttacc cagccaaatg ctttgctttg     4980

aagtattggg ttctgtgaaa atattgagca ttgtacttac cttatctagg ctgtgaaact     5040

gtcctacata ccagagaatc ataaaaacaa aaacctcact ggcagcaagc tgccgaataa     5100

caacagagtc tagaggacat atttgtgggc tgcacagata ttttaggaat ttcagaaatt     5160

agaacaggag ccaaaatgat ttacattggc gttggcactg attcctttaa atggtctggg     5220

aaagggggtt gggaagagga tggagctcaa ctggccagaa gaggagcagc tgcagtcctg     5280

atagcttctc tagcctcggt cttttgagtg ataagtagtc atgttgtttt catccagttg     5340

gtttcttgtc attcccaaga agaatctccc aggccacatc tttggggata actgacatac     5400

tggattagcc ttttcaaaag aaaagtcatc ctatttggtt ttatggggtg tgagttttgt     5460

gtgtacacac acagaaacat gtaaggtggt ttgggtcatg tttttaacca cctggcaata     5520

cagtccactt tctggtttct tttattgtgg gaagtaaatg gtcaagctgc tcaggcagtg     5580

aaaagatgtg gagaatgtcc gttgtcattc ttgccactgt attccatttg ctaccgagat     5640

ataacattaa ggtggacaca ttttctaact gtattaatta aaagtcaatg gatacagaga     5700

gtggattttc tccccaagtc ccatccctgc tgaagaccgc ttggatgaac tccccaaccc     5760

actgtgcccc tcccgcaaca ctaccagtag actttagaac catagttaac taagtctttt     5820

acctctgaga tacttaattc tgggaaaatt ggtgacaatt ttcaacttct aaataggtaa     5880

ctcgactgca aaataatcaa aactgataac aatgaaactg cggctcttaa acaaagccat     5940

gcatgccgtg catttgtatt gaaatgtctc catgatatga agccaaatat tcaatgtaac     6000

atacttaata tccaaaggtg gaaacaaaag aatgtagaga tccagtgtta agagttccat     6060

ttgcttcaat taattattta ccttcctgtg gaataatata tatatatata tttaatagaa     6120

ccatagatag actagtagaa tttagattat aaatgtgtga gtgcagatta tcctgctatt     6180

gcacaagcta gaggggggaa aaatctcaat tccagctggc aagatgctag ccaggacaca     6240

tataagaaag ttgcactaga ttgaatggtc acagaatcgg aggacatgga agaaaaagga     6300

aacttcggtg gttctgcagc agacatgggc taggtcatat gtggtttcta tgagttcgtg     6360

tctcaaaaaa aaaaggaggg ggggcatctg tccccggtgg agctcaccta tttggaatat     6420

ggggcatttg ttttttccac tgcaatgatt tcagtctggt ttcatcatgt tggaattcga     6480

tcacaccatt ttcaaacaat gttaacatag tccagctttt gtttttctca tctcttctga     6540

gaggagactc actgtttctg tctgaggaag ctcataccct cggcaaaaca tcaggacaaa     6600

taaagagaaa tgggggtacg cattcccaac agaagcagtg tgttatttgt tttaaaactc     6660

tgaacagaga tcttggaaat ctttcaaaaa gaccattgaa ttcttcattg gctgagaacg     6720

acgttttaaa atgtcttaaa taaggctttg tttgcattgt ttgagttcaa ggggccttat     6780

tattgaatgg aattgcacaa gcctttcttt gtgcaatcaa accattgtta ttggtagttc     6840

tgtaaaggaa actgtggaat cgaattggca gtggagtcat aaatctattt actgagtgtg     6900

gcttccaaga aatgttgcaa ttcaaaatgc actaagtctg tgatttattg gagatttgga     6960

gattctaaat aatattttta aaaaacttcc atgcaacttc tggtttaatg tttggcaact     7020

ccacatgata aaaaaataaa aacagcccaa ccgagtttcg gaattaagta ttcttctagt     7080

aagtgattca aacttgtaat atttgccaca ggactgactt atttatttac tagctagaag     7140

ctcttaagtt cacttgttta tcagggcata tacagaaggg tttgttaaaa ctcgatgtta     7200

actttacaac tttctgacct ggtgcatgaa ttctcaagta ctgtatttca ctgtgttggt     7260

gtgtctgatg gaaatttcga ggtggtccca caaaaatatt ttatgtagtg tgccttcaaa     7320

gagaaccatt tatttctctt cacttatcgt cccacaaagt cacatttggt ggtggtcagc     7380

caagtcgcat ctggtctagt tttactcttg tcccaatttt aaagagaaat gggaatgagt     7440

ttgccctggt gagacccata ccattgcaat gattatcttg agcacttaaa gtccagtgtt     7500

ggctgttagt gtatttgata ttctgcctgt ctcctcatgg ttgaaatatg tctgaagaat     7560

agcagcataa tctcttggct gtttatactt ttttaaactt tcctgtgttg taaatattgt     7620

atacttttgg tgattccagc tatgtaacct ctatgctctg taaggtgatt atttgtatat     7680

agcaacatgg cccagtgata ttatatagtt tcccaatgga gaggttattg agtaaccttt     7740

gcattagttt aaacactacc agaagaatgc tgagccaact ataaacactc aattttgtat     7800

gttttccaaa ttgtacttat tactgctttt gatactgtat tacgtgccaa tagtttccca     7860

atcacatagc aggcaagaga tattttgtac tttttgatcc actgtaatat ttaataaaaa     7920

atgttactat ctgtttcctt taaaaaaa                                        7948


<210>  140
<211>  1188
<212>  PRT
<213>  homo sapiens

<400>  140

Met Glu Pro Asn Ser Leu Gln Trp Val Gly Ser Pro Cys Gly Leu His 
1               5                   10                  15      


Gly Pro Tyr Ile Phe Tyr Lys Ala Phe Gln Phe His Leu Glu Gly Lys 
            20                  25                  30          


Pro Arg Ile Leu Ser Leu Gly Asp Phe Phe Phe Val Arg Cys Thr Pro 
        35                  40                  45              


Lys Asp Pro Ile Cys Ile Ala Glu Leu Gln Leu Leu Trp Glu Glu Arg 
    50                  55                  60                  


Thr Ser Arg Gln Leu Leu Ser Ser Ser Lys Leu Tyr Phe Leu Pro Glu 
65                  70                  75                  80  


Asp Thr Pro Gln Gly Arg Asn Ser Asp His Gly Glu Asp Glu Val Ile 
                85                  90                  95      


Ala Val Ser Glu Lys Val Ile Val Lys Leu Glu Asp Leu Val Lys Trp 
            100                 105                 110         


Val His Ser Asp Phe Ser Lys Trp Arg Cys Gly Phe His Ala Gly Pro 
        115                 120                 125             


Val Lys Thr Glu Ala Leu Gly Arg Asn Gly Gln Lys Glu Ala Leu Leu 
    130                 135                 140                 


Lys Tyr Arg Gln Ser Thr Leu Asn Ser Gly Leu Asn Phe Lys Asp Val 
145                 150                 155                 160 


Leu Lys Glu Lys Ala Asp Leu Gly Glu Asp Glu Glu Glu Thr Asn Val 
                165                 170                 175     


Ile Val Leu Ser Tyr Pro Gln Tyr Cys Arg Tyr Arg Ser Met Leu Lys 
            180                 185                 190         


Arg Ile Gln Asp Lys Pro Ser Ser Ile Leu Thr Asp Gln Phe Ala Leu 
        195                 200                 205             


Ala Leu Gly Gly Ile Ala Val Val Ser Arg Asn Pro Gln Ile Leu Tyr 
    210                 215                 220                 


Cys Arg Asp Thr Phe Asp His Pro Thr Leu Ile Glu Asn Glu Ser Ile 
225                 230                 235                 240 


Cys Asp Glu Phe Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys 
                245                 250                 255     


Pro Cys Pro Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Asn Asn Ser Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg 
        275                 280                 285             


Ser Ala Leu Thr Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser 
    290                 295                 300                 


Asn Glu Glu Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp 
305                 310                 315                 320 


Glu Gln Ala Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys 
                325                 330                 335     


Thr Pro Ile Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu 
            340                 345                 350         


Trp Thr Met Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Thr Ile 
        355                 360                 365             


Thr Ala Arg Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn 
    370                 375                 380                 


Pro Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg His Tyr Glu Arg 
385                 390                 395                 400 


Leu Ile Leu Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro 
                405                 410                 415     


Leu Pro Pro Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn 
            420                 425                 430         


Glu Asn Lys Thr Lys Val Ser Gly Thr Lys Arg Ile Lys His Glu Ile 
        435                 440                 445             


Pro Lys Ser Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala 
    450                 455                 460                 


Ala Glu Val Ser Ser Glu Gln Glu Lys Glu Gln Glu Thr Leu Ile Ser 
465                 470                 475                 480 


Gln Lys Ser Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys 
                485                 490                 495     


Ile Glu Gly Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val 
            500                 505                 510         


Asp Pro Glu Lys Asp Asn Glu Thr Asp Gln Gly Ser Asn Ser Glu Lys 
        515                 520                 525             


Val Ala Glu Glu Ala Gly Glu Lys Gly Pro Thr Pro Pro Leu Pro Ser 
    530                 535                 540                 


Ala Pro Leu Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser 
545                 550                 555                 560 


Lys Gln Pro Leu Thr Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu 
                565                 570                 575     


Ser Lys Leu Cys Cys Phe Thr Glu Ser Pro Glu Ser Glu Pro Gln Glu 
            580                 585                 590         


Ala Ser Phe Pro Ser Phe Pro Thr Thr Gln Pro Pro Leu Ala Asn Gln 
        595                 600                 605             


Asn Glu Thr Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala 
    610                 615                 620                 


Asn Cys Thr Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn 
625                 630                 635                 640 


Ala Leu Lys Gln Thr Pro Lys Val Leu Val Val Gln Ser Phe Asp Met 
                645                 650                 655     


Phe Lys Asp Lys Asp Leu Thr Gly Pro Met Asn Glu Asn His Gly Leu 
            660                 665                 670         


Asn Tyr Thr Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser 
        675                 680                 685             


Pro Leu Ala Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu 
    690                 695                 700                 


Ser Ser Ser Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys 
705                 710                 715                 720 


Lys Leu Ile Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Thr His 
                725                 730                 735     


His Gly Gln Ser Thr Asp His Met Ala Val Ser Arg Pro Ser Val Ile 
            740                 745                 750         


Gln His Val Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Thr 
        755                 760                 765             


Ile Asn Asp Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His 
    770                 775                 780                 


Arg Cys Ser Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr 
785                 790                 795                 800 


Val Leu Lys Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys 
                805                 810                 815     


Arg Ala Leu Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr 
            820                 825                 830         


Ser Ser Pro His Leu His Ser Leu Tyr Arg His Thr Glu His His Leu 
        835                 840                 845             


His Asn Glu Gln Thr Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu 
    850                 855                 860                 


Ser Glu Asn Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His 
865                 870                 875                 880 


Val Asn Tyr Leu Thr Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala 
                885                 890                 895     


Ala Glu Ala Pro Thr Asp Asp Gln Pro Thr Asp Leu Ser Leu Pro Lys 
            900                 905                 910         


Asn Pro His Lys Pro Thr Gly Lys Val Leu Gly Leu Ala His Ser Thr 
        915                 920                 925             


Thr Gly Pro Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly 
    930                 935                 940                 


Ser Gln Ser Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met 
945                 950                 955                 960 


Thr Met Ser Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly 
                965                 970                 975     


Lys Pro His His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met 
            980                 985                 990         


Val His Pro Ile Leu His Arg Lys  Met Ser Pro Gln Asn  Ile Gly Ala 
        995                 1000                 1005             


Ala Arg  Pro Ile Lys Arg Ser  Leu Glu Asp Leu Asp  Leu Val Ile 
    1010                 1015                 1020             


Ala Gly  Lys Lys Ala Arg Ala  Val Ser Pro Leu Asp  Pro Ser Lys 
    1025                 1030                 1035             


Glu Val  Ser Gly Lys Glu Lys  Ala Ser Glu Gln Glu  Ser Glu Gly 
    1040                 1045                 1050             


Ser Lys  Ala Ala His Gly Gly  His Ser Gly Gly Gly  Ser Glu Gly 
    1055                 1060                 1065             


His Lys  Leu Pro Leu Ser Ser  Pro Ile Phe Pro Gly  Leu Tyr Ser 
    1070                 1075                 1080             


Gly Ser  Leu Cys Asn Ser Gly  Leu Asn Ser Arg Leu  Pro Ala Gly 
    1085                 1090                 1095             


Tyr Ser  His Ser Leu Gln Tyr  Leu Lys Asn Gln Thr  Val Leu Ser 
    1100                 1105                 1110             


Pro Leu  Met Gln Pro Leu Ala  Phe His Ser Leu Val  Met Gln Arg 
    1115                 1120                 1125             


Gly Ile  Phe Thr Ser Pro Thr  Asn Ser Gln Gln Leu  Tyr Arg His 
    1130                 1135                 1140             


Leu Ala  Ala Ala Thr Pro Val  Gly Ser Ser Tyr Gly  Asp Leu Leu 
    1145                 1150                 1155             


His Asn  Ser Ile Tyr Pro Leu  Ala Ala Ile Asn Pro  Gln Ala Ala 
    1160                 1165                 1170             


Phe Pro  Ser Ser Gln Leu Ser  Ser Val His Pro Ser  Thr Lys Leu 
    1175                 1180                 1185             


<210>  141
<211>  4454
<212>  DNA
<213>  homo sapiens

<400>  141
gacgctcgag gggcgctcgg ctagtcccgc cagagcgcga gccgccagcc cgtaacggtc       60

gccagtgtga ggggcgggag ggaaagaaga ggggtttaaa ttagattttt taaaacacag      120

agcaagcgcc agaggcgtcg gcatcccagg tgtcgccgct tcctgctgca cagggctcgg      180

cgtacaggtc cctccctcct caagccccct ccccttctcc cgccctaccc tctggggctc      240

tgcggcgctt aagaggcggc cgcagcggcg gatccggcgg ctgctgcagc ccgggcggct      300

gccgagaagg agggagggga aacacaaagc cggctacgcg ctgcgagata acaagagtaa      360

tccacagact taaaacatga gctcagatgc cagccaaggc gtgattacca ctcctcctcc      420

tcccagcatg cctcacaaag agagatattt tgaccgcatc aatgaaaatg acccagaata      480

cattagggag aggaacatgt ctcctgatct acgacaagac ttcaacatga tggagcagag      540

gaaacgagtt actcagatcc tgcaaagtcc tgcctttcgg gaagacttgg aatgccttat      600

tcaagaacag atgaagaaag gccacaaccc aactggatta ctagcattac agcagattgc      660

agattacatc atggccaatt ctttctcggg tttttcttca cctcctctca gtcttggcat      720

ggtcacacct atcaatgacc ttcctggtgc agatacatcc tcatatgtga agggagaaaa      780

acttactcgc tgtaaacttg ccagcctgta cagacttgta gacttgtttg gatgggcaca      840

cctggcaaat acctatatct cagtaagaat aagtaaggag caagaccaca ttataataat      900

tcccagaggc ctatcttttt ctgaagctac agcctccaat ttggtgaaag tcaatataat      960

aggagaagtg gttgaccagg gaagtaccaa tttgaaaatt gaccatacag gattcagtcc     1020

ccatgctgca atctattcaa cacgtcctga tgttaagtgt gtgatacaca tccataccct     1080

tgcaacagca gctgtatcct ccatgaaatg tgggatcctt ccaatttctc aagagtctct     1140

tcttctggga gatgttgcct attatgacta ccaagggtca cttgaagaac aggaggagag     1200

aattcaactg cagaaggttc tgggaccaag ttgtaaggtg ctggtactca ggaatcatgg     1260

tgtggttgca cttggagaaa cattagagga ggcttttcat tatattttta atgtgcaact     1320

agcctgtgag attcaggtgc aggccctagc aggtgcaggt ggagtagaca atctccatgt     1380

actggacttt cagaagtata aagctttcac ttacactgta gcagcgtctg gtggaggagg     1440

tgtgaatatg ggttcccatc aaaaatggaa ggttggcgaa attgagtttg aagggcttat     1500

gaggactctg gacaacttgg ggtatagaac aggctatgct tacaggcatc ctctcattcg     1560

agagaagcct aggcacaaga gtgatgtgga aatcccagca actgtgactg ctttttcctt     1620

tgaagacgat acagtgccac tctctcctct caaatacatg gcacagaggc aacagcgtga     1680

aaaaacaaga tggctgaact caccaaatac ttacatgaaa gtgaatgtgc ctgaggagtc     1740

tcggaacgga gaaaccagtc cccgaaccaa aatcacgtgg atgaaagcag aagactcatc     1800

taaagttagt ggtggaacac ctatcaaaat tgaagatcca aatcagtttg ttcctttaaa     1860

cacaaacccg aatgaggtac tagaaaagag aaataagatt cgggaacaaa atcgatatga     1920

cttgaaaaca gcaggaccac aatctcagtt gcttgctgga attgttgtgg ataagccacc     1980

ttctactatg caatttgaag atgatgatca tggcccacca gctcctccta acccatttag     2040

tcatctcaca gaaggagaac ttgaagagta taagaggaca atcgaacgta aacaacaagg     2100

cctagaagat gctgagcagg aattactctc agatgacgct tcatctgttt cacaaattca     2160

gtctcaaact cagtcaccgc aaaatgtccc tgaaaaatta gaagaaaacc atgagctgtt     2220

ttccaagagc ttcatctcca tggaagtgcc tgtcatggta gtaaatggca aggatgatat     2280

gcatgatgtt gaagatgagc ttgctaagcg agtgagtagg ttaagcacaa gtacaaccat     2340

agaaaacatc gagattacta ttaagtctcc agagaaaatc gaagaagtcc tgtcacctga     2400

aggctcccct tcaaaatcgc catccaagaa aaagaagaaa ttccgcactc cttcttttct     2460

gaaaaagaac aaaaaaaagg agaaagttga ggcctaaata aagtcttttt ataattatta     2520

ttataacaat gtgacattgc acatctaaat accacattta agttgatcat taatatgcaa     2580

tggtagatca gattggggga tgtagcaaac tggactttaa gaactggaaa gaggttttac     2640

aaaagaaaaa ctttcagatt catctctcat tttatatgtc cagaaatggc tttgaatttt     2700

aagcaattac tagttttaat tagctctgcc ctcatgaagt attattataa ttcaccataa     2760

acagctatct gtctgaatta cttcaggcct tctccataat atctgttaga aagaaattgc     2820

cagtgagcaa gtgagaattt ttatttctca atacctgctt cacttgataa tcatattata     2880

attttttatc atgattattg actatatttt tggagtccca ttgtttcagt gggcattaac     2940

agaatgcttt aaaaacttct aagacaagaa tctatagcat tagtatacac tggcacataa     3000

ttttttaaaa agttttaaga aaagattcat ttggaatttt attcacagta taaaatttcc     3060

tcacctgaag taactttgtt tgccaaaaaa gttgttttaa taaactataa tttttgaaaa     3120

cttccttttt tattagttta gaaagcccct tatttttcaa caaaggggat tttgtacaca     3180

taacatgggt tatttagttt aactctggca aaaaaaaaaa aaaaaatttt gtatgttgat     3240

gtttgtatac cgttcagtat aaaagtgtcc taagcatatt agccaatctt ttcacagtag     3300

agcatactta aggctgcttg gtactgagta tacttaaata taactccaga atccagggac     3360

ttggtgttaa aacaggatta gagcatgtaa aggtacatct agattcatat ttgaatctta     3420

aactgtattt ttctcttagt attgctaatg agtaaagaaa agtctcataa ggtagccaaa     3480

tgaaaaagaa tgaaagggaa agtgaaaaat taaggggaca aaagatggga tgtgaaaaga     3540

agaattctag tttgatggtg actcatattc acgataggat acaaagtgtg atttgttgga     3600

aacatgtccc aaatttctaa aattctgctt ctctgccaaa agcaatgtct ttcttggttg     3660

atatttgagt tttaaaaggg tcaaatcttt ctaatttttt gtatctttag agggcagcac     3720

tagaagaaat cagcaggtct aatcccacca gtaagaaaac taccacttct tgatttttac     3780

agatttaaaa aaatcttttc agtgaccttt ctttttaatg taaatacaaa tttaaaccta     3840

ggcttaatat aggcgtttcc cctttcaccc aagtgatgtc acagttcgat gcaaaatcaa     3900

tgatccagaa tgatcgtggg taaaaataac tcaaagtgtt tcttaagggt gagttggcat     3960

gcaaaaaatt acattgatta cagtgtgttt tggagctggc tctgtttgtg tgcatatgat     4020

aatgcagagt tgagccagag cctggaaatg tcattctaga tctcactaac tactggaatc     4080

agtgttttaa tctcttggtg gaaactttca gttgcttaac tctctattgg aagatttttt     4140

taatgttcta catcatttat gttgtattac aatgtatgta gaaatagtaa cctgtgaact     4200

atgcttttcc ataacttttt aaaaatatat atatctaaat gaatgcaatg tgcataaata     4260

ttttttaaac ataacagtga actattgcac cttttgctaa tgcctctatt tacttgcttt     4320

ggcataaaga atgagccaat gaacctctgt gtcctgtgga aaaatgtata aatgttatct     4380

gatattgctc ttagatgtaa tgctaattaa tgttaaatca caaataaaca gtattttaaa     4440

tataaaaaaa aaaa                                                       4454


<210>  142
<211>  706
<212>  PRT
<213>  homo sapiens

<400>  142

Met Ser Ser Asp Ala Ser Gln Gly Val Ile Thr Thr Pro Pro Pro Pro 
1               5                   10                  15      


Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Asn Asp 
            20                  25                  30          


Pro Glu Tyr Ile Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Gln Asp 
        35                  40                  45              


Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
    50                  55                  60                  


Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Ile Gln Glu Gln Met Lys 
65                  70                  75                  80  


Lys Gly His Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                85                  90                  95      


Tyr Ile Met Ala Asn Ser Phe Ser Gly Phe Ser Ser Pro Pro Leu Ser 
            100                 105                 110         


Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
        115                 120                 125             


Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Lys Leu Ala Ser Leu 
    130                 135                 140                 


Tyr Arg Leu Val Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
145                 150                 155                 160 


Ile Ser Val Arg Ile Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                165                 170                 175     


Arg Gly Leu Ser Phe Ser Glu Ala Thr Ala Ser Asn Leu Val Lys Val 
            180                 185                 190         


Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
        195                 200                 205             


Asp His Thr Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
    210                 215                 220                 


Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
225                 230                 235                 240 


Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Leu 
                245                 250                 255     


Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Glu Glu Gln 
            260                 265                 270         


Glu Glu Arg Ile Gln Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
        275                 280                 285             


Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
    290                 295                 300                 


Glu Ala Phe His Tyr Ile Phe Asn Val Gln Leu Ala Cys Glu Ile Gln 
305                 310                 315                 320 


Val Gln Ala Leu Ala Gly Ala Gly Gly Val Asp Asn Leu His Val Leu 
                325                 330                 335     


Asp Phe Gln Lys Tyr Lys Ala Phe Thr Tyr Thr Val Ala Ala Ser Gly 
            340                 345                 350         


Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
        355                 360                 365             


Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
    370                 375                 380                 


Thr Gly Tyr Ala Tyr Arg His Pro Leu Ile Arg Glu Lys Pro Arg His 
385                 390                 395                 400 


Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                405                 410                 415     


Asp Asp Thr Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
            420                 425                 430         


Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
        435                 440                 445             


Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
    450                 455                 460                 


Lys Ile Thr Trp Met Lys Ala Glu Asp Ser Ser Lys Val Ser Gly Gly 
465                 470                 475                 480 


Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                485                 490                 495     


Asn Pro Asn Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
            500                 505                 510         


Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
        515                 520                 525             


Ile Val Val Asp Lys Pro Pro Ser Thr Met Gln Phe Glu Asp Asp Asp 
    530                 535                 540                 


His Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Thr Glu Gly 
545                 550                 555                 560 


Glu Leu Glu Glu Tyr Lys Arg Thr Ile Glu Arg Lys Gln Gln Gly Leu 
                565                 570                 575     


Glu Asp Ala Glu Gln Glu Leu Leu Ser Asp Asp Ala Ser Ser Val Ser 
            580                 585                 590         


Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Asn Val Pro Glu Lys Leu 
        595                 600                 605             


Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Ile Ser Met Glu Val 
    610                 615                 620                 


Pro Val Met Val Val Asn Gly Lys Asp Asp Met His Asp Val Glu Asp 
625                 630                 635                 640 


Glu Leu Ala Lys Arg Val Ser Arg Leu Ser Thr Ser Thr Thr Ile Glu 
                645                 650                 655     


Asn Ile Glu Ile Thr Ile Lys Ser Pro Glu Lys Ile Glu Glu Val Leu 
            660                 665                 670         


Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys 
        675                 680                 685             


Phe Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val 
    690                 695                 700                 


Glu Ala 
705     


<210>  143
<211>  5205
<212>  DNA
<213>  homo sapiens

<400>  143
gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg       60

ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc      120

catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc      180

cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc      240

caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat      300

cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga      360

gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg      420

gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct      480

gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct      540

gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca      600

gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat      660

gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga      720

cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct      780

catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc      840

tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga      900

ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt      960

cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac     1020

cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga     1080

caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac     1140

cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg     1200

ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca     1260

tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca     1320

tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc     1380

ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa     1440

gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct     1500

catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat     1560

gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc     1620

tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc     1680

tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag     1740

cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga     1800

cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga     1860

cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg     1920

gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa     1980

gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca     2040

gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac     2100

caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca     2160

catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa     2220

ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga     2280

gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta     2340

ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc     2400

actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc     2460

tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt     2520

tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa     2580

tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg     2640

gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga     2700

gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc     2760

ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag     2820

catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca     2880

ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg     2940

gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg     3000

ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat     3060

gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt     3120

ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc     3180

ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt     3240

ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg     3300

tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag     3360

cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct     3420

gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga     3480

gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg     3540

gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt     3600

ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt     3660

aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct     3720

ggagttggcc tccctgctga tcaagattga cattttccct gccaagcagg agaatggtga     3780

cctcagtccc ttcagtggta cgtccctgcg ggagcggggc tcagatgcct caggccagct     3840

gtttcatggc cgagcccggg aaggctcctt tgaatcccgc taccagcagc cgtttgagga     3900

cttccgcatc tcccaggagc atctcgcaga ccattttgac agtcgagaac gaagggcccc     3960

aagaaggact cgggtcaatg gagacaaccg cctctagttg taccccagcc tcgttggaga     4020

gcagcaggtg ctgtgcgcct tgtagaatgc cgcgaactgg gttctttgga agcagccccc     4080

tgtggcggcc ttccgggtct cgcagcctga agcctggatt ccagcagtga atgctagaca     4140

gaaaccaagc cattaatgag atgttattac tgttttgggc ctccatgccc cagctctgga     4200

tgaaggcaaa aactgtactg tgtttcgcat taagcacaca catctggccc tgacttctgg     4260

agatggatcc ttccatcttg tggggccagg accatggccg aagccccttg gagagagagg     4320

ctgcctcagc cagtggcaca ggagactcca aggagctact gacattccta agagtggagg     4380

aggaggagga gccttgctgg gccagggaaa caaagtttac attgtcctgt agctttaaaa     4440

ccacagctgg gcagggtgag aagctagatg cccctgcagt ttggccctgg agccagggca     4500

gaggaatgta gggcctgcat ggagaagggt tctgccctgc ctgaggagga ggacacagca     4560

caagggcaca ttgcccatgg ctgggaacat gacccagcct gaaagataca ggggatcatg     4620

ttaaaaatag cagtattatt tttcgtctca atggtattgt aactaagtta tttactcctc     4680

ctgctcctca cccctgtagg gaaaccttgg agaggagagt ggcaggtggg ctgcctgctg     4740

tgttaagagg acttagtttg tgatgtaagg cactgtcagg aatggggggc gggccagggt     4800

gggaagagaa gaaatagcag agcctatttt ggtgaggttt tttgttttta agtcaaagaa     4860

gactcagtat gctttccctg aggaatgaaa aagggattga ggagttgcct gactcctggg     4920

tgggtggggt acaggcagtt aggtgctgaa tgaagctgcc atccttgctg cagcttctaa     4980

ctggtaaaaa gatccaggga tggagatggg aaggttagaa aggcagccct cacctctgag     5040

gacagaggcc ggggtccagg cccgtgggcg caaaggtgcc tcatagcata gccagcattc     5100

agcacacaca aacctactgc ccacatttgg gctcagggtt ggccatttgc tagttctgct     5160

gccctcttaa gatctgactg ccaaataaat catcctcatg tcctt                     5205


<210>  144
<211>  1291
<212>  PRT
<213>  homo sapiens

<400>  144

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15      


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30          


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45              


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60                  


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80  


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95      


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110         


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125             


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140                 


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160 


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175     


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190         


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205             


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220                 


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240 


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255     


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270         


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285             


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300                 


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320 


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335     


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350         


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365             


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380                 


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400 


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415     


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430         


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445             


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460                 


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480 


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495     


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510         


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525             


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540                 


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560 


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575     


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590         


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605             


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620                 


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640 


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655     


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670         


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685             


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700                 


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720 


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735     


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750         


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765             


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780                 


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800 


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815     


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830         


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845             


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860                 


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880 


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895     


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910         


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925             


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940                 


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960 


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975     


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990         


Asn Lys Ala Lys Gly Lys Lys Phe  Leu Gln Tyr Asn Arg  Leu Gln Leu 
        995                 1000                 1005             


Ser Arg  Ile Tyr Pro Lys Gly  Gln Arg Leu Asp Ser  Ser Asn Tyr 
    1010                 1015                 1020             


Asp Pro  Leu Pro Met Trp Ile  Cys Gly Ser Gln Leu  Val Ala Leu 
    1025                 1030                 1035             


Asn Phe  Gln Thr Pro Asp Lys  Pro Met Gln Met Asn  Gln Ala Leu 
    1040                 1045                 1050             


Phe Met  Thr Gly Arg His Cys  Gly Tyr Val Leu Gln  Pro Ser Thr 
    1055                 1060                 1065             


Met Arg  Asp Glu Ala Phe Asp  Pro Phe Asp Lys Ser  Ser Leu Arg 
    1070                 1075                 1080             


Gly Leu  Glu Pro Cys Ala Ile  Ser Ile Glu Val Leu  Gly Ala Arg 
    1085                 1090                 1095             


His Leu  Pro Lys Asn Gly Arg  Gly Ile Val Cys Pro  Phe Val Glu 
    1100                 1105                 1110             


Ile Glu  Val Ala Gly Ala Glu  Tyr Asp Ser Thr Lys  Gln Lys Thr 
    1115                 1120                 1125             


Glu Phe  Val Val Asp Asn Gly  Leu Asn Pro Val Trp  Pro Ala Lys 
    1130                 1135                 1140             


Pro Phe  His Phe Gln Ile Ser  Asn Pro Glu Phe Ala  Phe Leu Arg 
    1145                 1150                 1155             


Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser Asp Gln  Asn Phe Leu 
    1160                 1165                 1170             


Ala Gln  Ala Thr Phe Pro Val  Lys Gly Leu Lys Thr  Gly Tyr Arg 
    1175                 1180                 1185             


Ala Val  Pro Leu Lys Asn Asn  Tyr Ser Glu Asp Leu  Glu Leu Ala 
    1190                 1195                 1200             


Ser Leu  Leu Ile Lys Ile Asp  Ile Phe Pro Ala Lys  Gln Glu Asn 
    1205                 1210                 1215             


Gly Asp  Leu Ser Pro Phe Ser  Gly Thr Ser Leu Arg  Glu Arg Gly 
    1220                 1225                 1230             


Ser Asp  Ala Ser Gly Gln Leu  Phe His Gly Arg Ala  Arg Glu Gly 
    1235                 1240                 1245             


Ser Phe  Glu Ser Arg Tyr Gln  Gln Pro Phe Glu Asp  Phe Arg Ile 
    1250                 1255                 1260             


Ser Gln  Glu His Leu Ala Asp  His Phe Asp Ser Arg  Glu Arg Arg 
    1265                 1270                 1275             


Ala Pro  Arg Arg Thr Arg Val  Asn Gly Asp Asn Arg  Leu 
    1280                 1285                 1290     


<210>  145
<211>  61
<212>  RNA
<213>  homo sapiens

<400>  145
gggcaggaga gaaccaagcc gaagaaaggg agacaaaaac agccaaagga acacgaggcc       60

c                                                                       61


<210>  146
<211>  2083
<212>  DNA
<213>  homo sapiens

<400>  146
ctccctgctc caccccgtgc ctagggcagc acaaaagcca atcgctagca aactccctgc       60

ctagcaaggc ccagcctggg gcagaaatgg ctgcaagtgg ccgaggtctc tgcaaggctg      120

tggccgcctc tcccttcccg gcgtggagac gagataacac ggaagccagg ggaggtctga      180

agcctgagta tgatgcggtg gtgataggag caggacacaa cggactggtg gctgcagcgt      240

acctgcagag actgggggtg aacaccgccg tcttcgagag gcgccatgtg atcgggggtg      300

cagctgtcac tgaggagatc atcccagggt ttaagttctc ccgcgcgtcc tacctgctca      360

gcctgctgag gccgcagatt tacactgatc tggagctgaa gaaacatggg ctgaggcttc      420

atcttcgaaa cccctactcc ttcaccccca tgctggaaga gggtgcaggc agcaaggtgc      480

ccaggtgcct tctgctgggc acagacatgg cagaaaacca gaagcagatc gcccagttct      540

cccagaagga tgcccaggtc tttcccaaat atgaggagtt catgcatcgc ttggcattag      600

ccattgaccc tctgctggat gcggcccccg tggacatggc ggccttccag catggctcct      660

tgctgcaaag gatgaggtcg ctctccaccc tcaagcccct gctgaaggca ggccgcatcc      720

tgggagccca gcttccccga tattatgagg tcctcacagc tcccattacc aaggtgctgg      780

atcagtggtt cgagtctgag cctttaaaag ccactctagc cacagatgca gtgattggag      840

ccatgacaag tccccacact ccggggagtg ggtatgtgct gctgcaccat gtgatggggg      900

gcctggaggg aatgcagggg gcctggggct acgtccaggg gggcatgggt gccctctctg      960

atgcgatcgc aagctcagcc accacacatg gagcaagcat cttcactgaa aagacagtgg     1020

cgaaggtgca ggtgaacagt gaaggctgtg ttcaaggagt tgtgctggaa gatggcacag     1080

aggtgagaag caaaatggtg ctgtccaaca catcaccgca gatcaccttc ctgaagctga     1140

cgccacagga gtggcttcct gaggagttcc tggagagaat ctctcagctg gacacccggt     1200

cgcctgtcac caagatcaat gtggccgtag acaggctgcc cagcttcctg gcggccccca     1260

atgctcccag gggccagccg ctgccccatc accaatgctc catccacctg aactgtgaag     1320

acaccctcct ccttcatcag gcctttgaag atgccatgga tggcctgcct tcccacaggc     1380

ctgtgattga gctctgcatc ccttcctcgc tggaccccac cctggctccc cctggctgcc     1440

atgtagtctc cctcttcact cagtacatgc cctatacgct ggctggaggc aaggcctggg     1500

acgagcagga gagagacgct tatgcagaca gagtgtttga ttgcatcgag gtctatgccc     1560

ctggcttcaa ggactctgtg gttggcagag acatcctcac accaccagat ttggagagaa     1620

tcttcgggct tcctggaggg aacatattcc actgcgccat gtccctggac cagctctact     1680

tcgcccgccc cgtgcccctg cattctggct accgctgccc tctccagggc ctgtatctct     1740

gtggaagtgg ggctcatcct ggaggaggtg tgatgggagc tgctgggcga aatgcagcac     1800

atgtggcctt tagggacctc aagagcatgt gaccctgaac cagctctgac ccaggaagaa     1860

gactccaccc ctgaattcca agtgctccat tggatcagct tcccaggaag ttcagcttcg     1920

ggttagtaca taaggccacc acaatgctca agaaattatt ttagaaaaaa cgtacgagtt     1980

acatttagtg caagttgacc ttatgcccat gcctccatac atggactggt tctgttttat     2040

taaaactaat atttcataca gattaaaaaa aaaaaaaaaa aaa                       2083


<210>  147
<211>  581
<212>  PRT
<213>  homo sapiens

<400>  147

Met Ala Ala Ser Gly Arg Gly Leu Cys Lys Ala Val Ala Ala Ser Pro 
1               5                   10                  15      


Phe Pro Ala Trp Arg Arg Asp Asn Thr Glu Ala Arg Gly Gly Leu Lys 
            20                  25                  30          


Pro Glu Tyr Asp Ala Val Val Ile Gly Ala Gly His Asn Gly Leu Val 
        35                  40                  45              


Ala Ala Ala Tyr Leu Gln Arg Leu Gly Val Asn Thr Ala Val Phe Glu 
    50                  55                  60                  


Arg Arg His Val Ile Gly Gly Ala Ala Val Thr Glu Glu Ile Ile Pro 
65                  70                  75                  80  


Gly Phe Lys Phe Ser Arg Ala Ser Tyr Leu Leu Ser Leu Leu Arg Pro 
                85                  90                  95      


Gln Ile Tyr Thr Asp Leu Glu Leu Lys Lys His Gly Leu Arg Leu His 
            100                 105                 110         


Leu Arg Asn Pro Tyr Ser Phe Thr Pro Met Leu Glu Glu Gly Ala Gly 
        115                 120                 125             


Ser Lys Val Pro Arg Cys Leu Leu Leu Gly Thr Asp Met Ala Glu Asn 
    130                 135                 140                 


Gln Lys Gln Ile Ala Gln Phe Ser Gln Lys Asp Ala Gln Val Phe Pro 
145                 150                 155                 160 


Lys Tyr Glu Glu Phe Met His Arg Leu Ala Leu Ala Ile Asp Pro Leu 
                165                 170                 175     


Leu Asp Ala Ala Pro Val Asp Met Ala Ala Phe Gln His Gly Ser Leu 
            180                 185                 190         


Leu Gln Arg Met Arg Ser Leu Ser Thr Leu Lys Pro Leu Leu Lys Ala 
        195                 200                 205             


Gly Arg Ile Leu Gly Ala Gln Leu Pro Arg Tyr Tyr Glu Val Leu Thr 
    210                 215                 220                 


Ala Pro Ile Thr Lys Val Leu Asp Gln Trp Phe Glu Ser Glu Pro Leu 
225                 230                 235                 240 


Lys Ala Thr Leu Ala Thr Asp Ala Val Ile Gly Ala Met Thr Ser Pro 
                245                 250                 255     


His Thr Pro Gly Ser Gly Tyr Val Leu Leu His His Val Met Gly Gly 
            260                 265                 270         


Leu Glu Gly Met Gln Gly Ala Trp Gly Tyr Val Gln Gly Gly Met Gly 
        275                 280                 285             


Ala Leu Ser Asp Ala Ile Ala Ser Ser Ala Thr Thr His Gly Ala Ser 
    290                 295                 300                 


Ile Phe Thr Glu Lys Thr Val Ala Lys Val Gln Val Asn Ser Glu Gly 
305                 310                 315                 320 


Cys Val Gln Gly Val Val Leu Glu Asp Gly Thr Glu Val Arg Ser Lys 
                325                 330                 335     


Met Val Leu Ser Asn Thr Ser Pro Gln Ile Thr Phe Leu Lys Leu Thr 
            340                 345                 350         


Pro Gln Glu Trp Leu Pro Glu Glu Phe Leu Glu Arg Ile Ser Gln Leu 
        355                 360                 365             


Asp Thr Arg Ser Pro Val Thr Lys Ile Asn Val Ala Val Asp Arg Leu 
    370                 375                 380                 


Pro Ser Phe Leu Ala Ala Pro Asn Ala Pro Arg Gly Gln Pro Leu Pro 
385                 390                 395                 400 


His His Gln Cys Ser Ile His Leu Asn Cys Glu Asp Thr Leu Leu Leu 
                405                 410                 415     


His Gln Ala Phe Glu Asp Ala Met Asp Gly Leu Pro Ser His Arg Pro 
            420                 425                 430         


Val Ile Glu Leu Cys Ile Pro Ser Ser Leu Asp Pro Thr Leu Ala Pro 
        435                 440                 445             


Pro Gly Cys His Val Val Ser Leu Phe Thr Gln Tyr Met Pro Tyr Thr 
    450                 455                 460                 


Leu Ala Gly Gly Lys Ala Trp Asp Glu Gln Glu Arg Asp Ala Tyr Ala 
465                 470                 475                 480 


Asp Arg Val Phe Asp Cys Ile Glu Val Tyr Ala Pro Gly Phe Lys Asp 
                485                 490                 495     


Ser Val Val Gly Arg Asp Ile Leu Thr Pro Pro Asp Leu Glu Arg Ile 
            500                 505                 510         


Phe Gly Leu Pro Gly Gly Asn Ile Phe His Cys Ala Met Ser Leu Asp 
        515                 520                 525             


Gln Leu Tyr Phe Ala Arg Pro Val Pro Leu His Ser Gly Tyr Arg Cys 
    530                 535                 540                 


Pro Leu Gln Gly Leu Tyr Leu Cys Gly Ser Gly Ala His Pro Gly Gly 
545                 550                 555                 560 


Gly Val Met Gly Ala Ala Gly Arg Asn Ala Ala His Val Ala Phe Arg 
                565                 570                 575     


Asp Leu Lys Ser Met 
            580     


<210>  148
<211>  1957
<212>  DNA
<213>  homo sapiens

<400>  148
ctgtttgcat ctctgcaacc acttcagaag gcacgtgttt ggtttgctct gagcctaacc       60

tagagtgctc gcagcagtct ttcagttgag cttggggact gcagctgtgg ggagatttca      120

gtgcattgcc tcccctgggt gctcttcatc ttggatttga aagttgagag cagcatgttt      180

tgcccactga aactcatcct gctgccagtg ttactggatt attccttggg cctgaatgac      240

ttgaatgttt ccccgcctga gctaacagtc catgtgggtg attcagctct gatgggatgt      300

gttttccaga gcacagaaga caaatgtata ttcaagatag actggactct gtcaccagga      360

gagcacgcca aggacgaata tgtgctatac tattactcca atctcagtgt gcctattggg      420

cgcttccaga accgcgtaca cttgatgggg gacatcttat gcaatgatgg ctctctcctg      480

ctccaagatg tgcaagaggc tgaccaggga acctatatct gtgaaatccg cctcaaaggg      540

gagagccagg tgttcaagaa ggcggtggta ctgcatgtgc ttccagagga gcccaaagag      600

ctcatggtcc atgtgggtgg attgattcag atgggatgtg ttttccagag cacagaagtg      660

aaacacgtga ccaaggtaga atggatattt tcaggacggc gcgcaaagga ggagattgta      720

tttcgttact accacaaact caggatgtct gtggagtact cccagagctg gggccacttc      780

cagaatcgtg tgaacctggt gggggacatt ttccgcaatg acggttccat catgcttcaa      840

ggagtgaggg agtcagatgg aggaaactac acctgcagta tccacctagg gaacctggtg      900

ttcaagaaaa ccattgtgct gcatgtcagc ccggaagagc ctcgaacact ggtgaccccg      960

gcagccctga ggcctctggt cttgggtggt aatcagttgg tgatcattgt gggaattgtc     1020

tgtgccacaa tcctgctgct ccctgttctg atattgatcg tgaagaagac ctgtggaaat     1080

aagagttcag tgaattctac agtcttggtg aagaacacga agaagactaa tccagagata     1140

aaagaaaaac cctgccattt tgaaagatgt gaaggggaga aacacattta ctccccaata     1200

attgtacggg aggtgatcga ggaagaagaa ccaagtgaaa aatcagaggc cacctacatg     1260

accatgcacc cagtttggcc ttctctgagg tcagatcgga acaactcact tgaaaaaaag     1320

tcaggtgggg gaatgccaaa aacacagcaa gccttttgag aagaatggag agtcccttca     1380

tctcagcagc ggtggagact ctctcctgtg tgtgtcctgg gccactctac cagtgatttc     1440

agactcccgc tctcccagct gtcctcctgt ctcattgttt ggtcaataca ctgaagatgg     1500

agaatttgga gcctggcaga gagactggac agctctggag gaacaggcct gctgagggga     1560

ggggagcatg gacttggcct ctggagtggg acactggccc tgggaaccag gctgagctga     1620

gtggcctcaa accccccgtt ggatcagacc ctcctgtggg cagggttctt agtggatgag     1680

ttactgggaa gaatcagaga taaaaaccaa cccaaatcat tcctctggca cattatttct     1740

aaataagtgt tgtttgtgga aatcgtccta tttttatgcc tcggttgagg gggcaagtaa     1800

agtcctggtg aggaatttac agttagaaac ttttggaaaa actgaagttc ctggaggaaa     1860

gccaaaccgt gctaacacac tagaggctgg ttttggtcct gggaaaggtt tggggtgaat     1920

gggttggaag tagggtatga atacagtttt gggattt                              1957


<210>  149
<211>  394
<212>  PRT
<213>  homo sapiens

<400>  149

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  150
<211>  2805
<212>  DNA
<213>  homo sapiens

<400>  150
ctccttgcac gggccggccc agcttccccg cccctggcgt ccgctccctc ccgctcgcag       60

cttacttaac ctggcccggg cggcggaggc gctctcactt ccctggagcc gcccgcttgc      120

ccgtcggtcg ctagctcgct cggtgcgcgt cgtcccgctc catggcgctc ttcgtgcggc      180

tgctggctct cgccctggct ctggccctgg gccccgccgc gaccctggcg ggtcccgcca      240

agtcgcccta ccagctggtg ctgcagcaca gcaggctccg gggccgccag cacggcccca      300

acgtgtgtgc tgtgcagaag gttattggca ctaataggaa gtacttcacc aactgcaagc      360

agtggtacca aaggaaaatc tgtggcaaat caacagtcat cagctacgag tgctgtcctg      420

gatatgaaaa ggtccctggg gagaagggct gtccagcagc cctaccactc tcaaaccttt      480

acgagaccct gggagtcgtt ggatccacca ccactcagct gtacacggac cgcacggaga      540

agctgaggcc tgagatggag gggcccggca gcttcaccat cttcgcccct agcaacgagg      600

cctgggcctc cttgccagct gaagtgctgg actccctggt cagcaatgtc aacattgagc      660

tgctcaatgc cctccgctac catatggtgg gcaggcgagt cctgactgat gagctgaaac      720

acggcatgac cctcacctct atgtaccaga attccaacat ccagatccac cactatccta      780

atgggattgt aactgtgaac tgtgcccggc tgctgaaagc cgaccaccat gcaaccaacg      840

gggtggtgca cctcatcgat aaggtcatct ccaccatcac caacaacatc cagcagatca      900

ttgagatcga ggacaccttt gagacccttc gggctgctgt ggctgcatca gggctcaaca      960

cgatgcttga aggtaacggc cagtacacgc ttttggcccc gaccaatgag gccttcgaga     1020

agatccctag tgagactttg aaccgtatcc tgggcgaccc agaagccctg agagacctgc     1080

tgaacaacca catcttgaag tcagctatgt gtgctgaagc catcgttgcg gggctgtctg     1140

tagagaccct ggagggcacg acactggagg tgggctgcag cggggacatg ctcactatca     1200

acgggaaggc gatcatctcc aataaagaca tcctagccac caacggggtg atccactaca     1260

ttgatgagct actcatccca gactcagcca agacactatt tgaattggct gcagagtctg     1320

atgtgtccac agccattgac cttttcagac aagccggcct cggcaatcat ctctctggaa     1380

gtgagcggtt gaccctcctg gctcccctga attctgtatt caaagatgga acccctccaa     1440

ttgatgccca tacaaggaat ttgcttcgga accacataat taaagaccag ctggcctcta     1500

agtatctgta ccatggacag accctggaaa ctctgggcgg caaaaaactg agagtttttg     1560

tttatcgtaa tagcctctgc attgagaaca gctgcatcgc ggcccacgac aagaggggga     1620

ggtacgggac cctgttcacg atggaccggg tgctgacccc cccaatgggg actgtcatgg     1680

atgtcctgaa gggagacaat cgctttagca tgctggtagc tgccatccag tctgcaggac     1740

tgacggagac cctcaaccgg gaaggagtct acacagtctt tgctcccaca aatgaagcct     1800

tccgagccct gccaccaaga gaacggagca gactcttggg agatgccaag gaacttgcca     1860

acatcctgaa ataccacatt ggtgatgaaa tcctggttag cggaggcatc ggggccctgg     1920

tgcggctaaa gtctctccaa ggtgacaagc tggaagtcag cttgaaaaac aatgtggtga     1980

gtgtcaacaa ggagcctgtt gccgagcctg acatcatggc cacaaatggc gtggtccatg     2040

tcatcaccaa tgttctgcag cctccagcca acagacctca ggaaagaggg gatgaacttg     2100

cagactctgc gcttgagatc ttcaaacaag catcagcgtt ttccagggct tcccagaggt     2160

ctgtgcgact agcccctgtc tatcaaaagt tattagagag gatgaagcat tagcttgaag     2220

cactacagga ggaatgcacc acggcagctc tccgccaatt tctctcagat ttccacagag     2280

actgtttgaa tgttttcaaa accaagtatc acactttaat gtacatgggc cgcaccataa     2340

tgagatgtga gccttgtgca tgtgggggag gagggagaga gatgtacttt ttaaatcatg     2400

ttccccctaa acatggctgt taacccactg catgcagaaa cttggatgtc actgcctgac     2460

attcacttcc agagaggacc tatcccaaat gtggaattga ctgcctatgc caagtccctg     2520

gaaaaggagc ttcagtattg tggggctcat aaaacatgaa tcaagcaatc cagcctcatg     2580

ggaagtcctg gcacagtttt tgtaaagccc ttgcacagct ggagaaatgg catcattata     2640

agctatgagt tgaaatgttc tgtcaaatgt gtctcacatc tacacgtggc ttggaggctt     2700

ttatggggcc ctgtccaggt agaaaagaaa tggtatgtag agcttagatt tccctattgt     2760

gacagagcca tggtgtgttt gtaataataa aaccaaagaa acata                     2805


<210>  151
<211>  683
<212>  PRT
<213>  homo sapiens

<400>  151

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  152
<211>  6489
<212>  DNA
<213>  homo sapiens

<400>  152
gcgcgtgcgc gcgcccggcc ggccgtcgcc gcggtgaccg tcctcggagt ccgtcggctc       60

gcgccccgcc cccgtcgccc cctcccctgt cgcgcgctgg ggctgtttct cgctccttcc      120

gagttaccgc cgccgtcgcc gccgctcctc ctctcccggt cctgggtttc cttggcgctg      180

cggccgccgc tccctctgcg acctgtatga ggaggaggag gaggaggatg tgaagatggc      240

ggagctgcag atgctgctgg aagaggaaat cccggggggc cgccgggccc tcttcgacag      300

ctacacaaat ctggaacggg tggccgatta ctgcgagaac aactacatac agtcagcaga      360

taagcagaga gccctagaag aaaccaaagc ctacaccacc caatccttag caagtgttgc      420

ctatctgata aacaccttgg ccaacaatgt cctgcagatg ctggatatcc aggcatccca      480

gctacgaagg atggaatctt caatcaatca tatttcacaa acagttgata ttcataaaga      540

gaaagttgca agaagagaaa ttggtatttt gactaccaat aaaaacactt caaggacaca      600

taagattatt gctccagcca accttgaacg accagttcgt tatattagaa aacctattga      660

ctatacaatt ctagatgata ttggacatgg agtaaaggtg agtacccaga acatgaagat      720

gggtgggctg ccgcgtacaa cacctccaac tcagaagccc cctagtcccc ctatgtcagg      780

gaaagggaca cttgggcggc actcccccta tcgcacactg gagccagtgc gtcctccagt      840

ggtaccaaat gattacgtac ctagcccaac ccgtaatatg gctccctcgc agcagagccc      900

tgtgaggaca gcttctgtga atcaaagaaa tcgaacttac agcagcagtg ggagtagtgg      960

agggagccac ccaagtagtc ggagcagcag tcgagagaac agtggaagtg gtagtgtggg     1020

ggttcctatt gctgttccta ctccatctcc tcccagtgtc tttccaggtc atcctgtaca     1080

gttctacagc atgaataggc ctgcctctcg ccatactccc ccaacaatag ggggctcgtt     1140

gccctataga cgccctcctt ccattacttc acaaacaagc cttcagaatc agatgaatgg     1200

aggacctttt tatagccaga atccagtatc tcttgctcct cctcctccct ccatcctaca     1260

ggtaactcct cagttacctt taatgggatt tgtggccaga gtccaagaaa atatttcaga     1320

tacaccacct ccaccgccac ctgtggaaga accagtcttt gatgagtctc ccccacctcc     1380

tcctcctcca gaagattacg aagaggagga agctgctgtg gttgagtata gtgatcctta     1440

tgctgaagag gacccaccgt gggctccacg ttcttacttg gaaaaggttg tggcaattta     1500

tgactataca aaagacaagg aagatgagct gtcctttcag gaaggagcca ttatttatgt     1560

catcaagaag aatgacgatg gttggtatga gggagttatg aatggagtga ctgggctttt     1620

tcctgggaat tacgttgagt ctatcatgca ttattctgag taaagctcag cagggctgtg     1680

cttgcctcac aggaatagtc aggtcttccc agattatctg aaggccctgg ggattccact     1740

ccagtaaagt agaatgaagg atacaaatga taaaaattac actttttttt ttggtttatt     1800

ccccagtatt aaaaacaaag caagctgagt ctgaacaaat ggatctttct gccatcattt     1860

gtacaatgct gagctgtctg gattgaaata aaatgaccat ttttatgtat gtcaaaggta     1920

taacagcata actgtgtagc caaaacaaaa tcagattaag actgattcag aaaaatctgg     1980

gatctttctc aggaatactg tatacccttg ggatttctcc tcctgcagaa tctgtggcat     2040

tggatgttct tcattgcctg tgctaagggg ttaacctcat ggcccagtgg gtaccctagc     2100

cccttctttt cttccacttg tatgaagagg agggaaccaa catttaaata ccacacttaa     2160

ccatttttac aattatttca gatggctttt ttcctctgtg acactgtaaa ttctgcattc     2220

tctcagcact tgagtgcacc aaacgagtga atgctgaact cacttgcatc ccttcatgtt     2280

tctgtttgtg gattataagg atgatgaaat gtgaaagtct cccaacactc tgagggtggt     2340

gaacgattgc cacccgtttg attttaatgt gctgctgcat gagactgcat tgttgctaat     2400

ggccagtgta cccagatgtg aagtgtggta ggctggttca tatgtggagg tgggtgtgtg     2460

aagctagaca cgaaggtccc taaggttctg aagagacttg aactgtggaa atgctcttag     2520

caggcatccc gaacccctgc ttcggtgctg ttttgaggag taggatcttg gagttcagac     2580

caactatgac tatcatttcc ttcactatct agaaaaacgc tattctactt tggaagagaa     2640

tagtagttat tttcaagtct cctgacagtc actgggagta caaggtttgc taatgtgctc     2700

tctggacgtt attaatggcc agtattagtt gctgctgtat tactgactcg cttagctgta     2760

gaaagggtaa tactctcctg attttgtatg attggactct taagtagctg ctgttagtca     2820

gaattaaaac ccatctcaga ctaagaatat aatgaataag attaataggc caaaatatgt     2880

atctaatcac attgataaaa attaatataa ctgacacaat aaaacacatt tcccccatct     2940

gtacaataaa tacagcttca aattcagtgg agtctgtagg gcagataact ttaatcatca     3000

ctactgtagt cagtataaga aatgctgaaa aaaatccagg agggcttgtc tctttgtggg     3060

tggtcactgt gatgttgggc cagctcctgt tcaggtccag agctgctaac gtgggttcta     3120

ctcagtccca gtgacttggc cagaatagag ctttgccagg taactgccct gtgctaggtg     3180

aaaggggaaa agcagtagct ggatatattt caaatgaggt tttgaacaag ttcagaaagt     3240

ggaacttgat tgaaaagtga acaagtgtag tagtgtgtga gaaaattcag atggtgtcgg     3300

atgcagaagt taatattcca cttaatgtta tctgagcatt aaaaatcatc agcatttaac     3360

tgagacccca ctatagagtt tccttatcaa gactttttgg ttttaaagtt gtttttaatg     3420

cattgcaagt tacaatagct attttgcttt tagatttttc ccagcacttt gtatttatta     3480

gctttcatta acttgcctcc agtatacatt ccacttcgtg cttttcttag gtcatttcta     3540

catcccttat tccttgtttt cctgcagtgt aatggccctg aatgtcctct gagccttcag     3600

ctccattatg gacccaaact agactatact tggataagtt aagctcttct tcgtgtactg     3660

gtctataatt agaaaaactg ttttaaatta gatgttccca ttatttattt aaacagcttt     3720

ttgctgagaa agcttagtgg attaatgagg cagagggtgt tttgaaatcc aataaatagt     3780

tcccacaggc tgggtgtggt ggcttatgcc tgtaatccca gcactttcgg aggccgaggt     3840

gggtggatca tgaggtcaat aaattgagac catcctggcc aacatggtga aaccccatct     3900

ctactaaaaa cacaaaaatt agctgggcgt ggtggcgcac acctgtagtc ccagctactt     3960

gggaggctga ggcaggagaa tcactggaac ctgggaggca gaggttgcag tgagccgaga     4020

ttgtgccact gcactccagc ctggtgacag agcgagactc catcaaaaaa aaaaaaaaaa     4080

agttcccaca gctcaccact acagaagcag ggaagacaac tatgcagaaa acagagttag     4140

tggcggtcag caggaatgca gctggtcttt tggaccccta cgggatgggg gcagtgcaga     4200

agacactggt gaagtccttt atactgaaga cctgtggttg ggagcagggg tagtccatgg     4260

gtctgctgat tttttttccc tatttagtac taatgtgtgt gtgatctttg ttttacaaac     4320

agtacctttt gggttttctg catattttat aatttttgta cagttttgaa ttctatagat     4380

tgtcttggaa ggatactgtg tgatgggtca ggcacacagt aattggagac ttttaatgta     4440

tgtaatattt catagattgc atgctattaa tcatctgtga gggtagtatt ttttgtttta     4500

ttgtaagttt ccctcttttt ttataaatta aaagatggtt ggtattagga atttcaaatg     4560

aatgcagaaa atcttacatg ctgtgtacta ttaatattat aacagacgat ccaagtccaa     4620

aatctgacca ataaagcaac cattttatca agatagaggg attctaatgg gagaggggat     4680

tcttccctcc tgaagtttgt gtgtccagtc cccttaaaaa aaatgaatag ttgtcttttc     4740

ttgtcatatt aatactcgaa agtccatggt ggtattaatg aaagtacact ttattgttgc     4800

ctttgaactt acggccaagg caataaatca gaaacaaaaa tagtgccaat gtgtcaaaat     4860

cgacatctga gagattcagc ctcccatttg gaataaatat gaatcttcta agctatcttg     4920

tttaatattt tccatcattt agctacttcc tatctccctc agaggcgcct gctgttccca     4980

ttttagagtt gacagtggcc tgctaatttt gctatgttcc taaaagttac tgggtgtgag     5040

acattttcat cccctccttt ttcctactgc tggtgtttat tatccagcta gacaatattt     5100

tatgcatatt taccgtgatg tctggaccgt acctgtgctc cttggcagtt tatgttgaag     5160

ataactaaag atttttctct ttgggaggca tcaaaatgat ggtagtttgc ttttatcttt     5220

ttatgttcat tttcttttag taggtgacct ttctgcatta agaactgttt ttatctttta     5280

ctaccttttc ttttctcctt tgtggagaca gcatgacatg tcctgaaggt cacctttgcc     5340

tttgaaaaag gtttgatgga ggaattcaca ggtgactgac aagtctttga aaagaatggg     5400

atctgctcac ttctggtctt tttggccggg aactcctgat tggtgttaag gtggtaattt     5460

cccccatata agatttagaa tcactgagtt tgagctagat gaaattttta aaatttctgg     5520

ttgtctcatt agactgatga ggtgagtttt cttcttcata tgaacagcta gttaataaca     5580

gcagagttct cactcagtgc tcagtactta attttccact gcaccacaac tgtcttaact     5640

aaatgtgctg tatttttctt taaaagttaa gagttctatt tggtgttttc aggaatatac     5700

gtgaaaagac atgccatgtt ttggtaaata ccatcagagt tgtgtaaagg cgtgtactaa     5760

gtgcaatctt aatttgtgga aataatcttc atttacccct cctaaaacta cactcagtat     5820

aaacactttc ccataaggtg tgtgcagtaa aaatgttata ttactccaac actggcagga     5880

gcacagcaca gcagccttat tggagagagc cttataaaag tgattaaatg gaggcattga     5940

gctcattacc tttaagttta ctttgtgctg acctttgttc ctgttttgag aatctcatat     6000

aattattaaa aaaaaaaaac aattaaaacg aaacggcggg gcctagctgt gtataaatga     6060

tccttgctga atatcttaag gttttttgta agaaaaaaga aaaaccaaca aaaaaagctt     6120

attttcacat taaaatgaaa cctcttttgc aacttaagaa ttctatggaa aagcagtttt     6180

tatcatattt tgtgtccatg caccattttt cttaaaatgg cttacaaaaa agaatgtaaa     6240

caatttgtga tctggccagt tgtactttta gctcccagag ggagagttgg tggtattatg     6300

agttgagtaa aaaccatcca ggggaacttg agggagcagt ctgttgccag taatgttcct     6360

tgtgtgccat taaaccacct ccagatgagt ggaggaacat cactttttaa ttttttaatt     6420

gtatttggaa ttgttgccgt gtactaagaa cttgacctaa ataaaatccc acaaagtata     6480

aaaaaaaaa                                                             6489


<210>  153
<211>  475
<212>  PRT
<213>  homo sapiens

<400>  153

Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Val Ser Thr Gln Asn Met 
145                 150                 155                 160 


Lys Met Gly Gly Leu Pro Arg Thr Thr Pro Pro Thr Gln Lys Pro Pro 
                165                 170                 175     


Ser Pro Pro Met Ser Gly Lys Gly Thr Leu Gly Arg His Ser Pro Tyr 
            180                 185                 190         


Arg Thr Leu Glu Pro Val Arg Pro Pro Val Val Pro Asn Asp Tyr Val 
        195                 200                 205             


Pro Ser Pro Thr Arg Asn Met Ala Pro Ser Gln Gln Ser Pro Val Arg 
    210                 215                 220                 


Thr Ala Ser Val Asn Gln Arg Asn Arg Thr Tyr Ser Ser Ser Gly Ser 
225                 230                 235                 240 


Ser Gly Gly Ser His Pro Ser Ser Arg Ser Ser Ser Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Gly Ser Val Gly Val Pro Ile Ala Val Pro Thr Pro Ser Pro 
            260                 265                 270         


Pro Ser Val Phe Pro Gly His Pro Val Gln Phe Tyr Ser Met Asn Arg 
        275                 280                 285             


Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser Leu Pro Tyr 
    290                 295                 300                 


Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln Asn Gln Met 
305                 310                 315                 320 


Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Leu Ala Pro Pro 
                325                 330                 335     


Pro Pro Ser Ile Leu Gln Val Thr Pro Gln Leu Pro Leu Met Gly Phe 
            340                 345                 350         


Val Ala Arg Val Gln Glu Asn Ile Ser Asp Thr Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Val Glu Glu Pro Val Phe Asp Glu Ser Pro Pro Pro Pro Pro Pro 
    370                 375                 380                 


Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala Val Val Glu Tyr Ser Asp 
385                 390                 395                 400 


Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala Pro Arg Ser Tyr Leu Glu 
                405                 410                 415     


Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys Asp Lys Glu Asp Glu Leu 
            420                 425                 430         


Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val Ile Lys Lys Asn Asp Asp 
        435                 440                 445             


Gly Trp Tyr Glu Gly Val Met Asn Gly Val Thr Gly Leu Phe Pro Gly 
    450                 455                 460                 


Asn Tyr Val Glu Ser Ile Met His Tyr Ser Glu 
465                 470                 475 


<210>  154
<211>  3575
<212>  DNA
<213>  homo sapiens

<400>  154
aggattctaa aaagagcaat ggttcacaag gaaacttctg cctcaggtgg ggagaggagt       60

ccatagatca gggaaactta tgtcttggtg aaatggaaga ccatgtttct aaacacctgt      120

cgccaggtta cttgaatttc cactagagga gcagaaatgc caccaatgcc aagtgcccca      180

cctgtgcatc cacctccaga tggaggatgg ggttggattg tggttggagc agcttttatc      240

tccattggat tttcctatgc attccccaaa gctgtcaccg tattcttcaa agaaattcag      300

caaatattcc acactaccta cagtgaaata gcatggattt catccattat gctggctgtt      360

atgtacgcag gaggtcctgt aagtagtgtt ttggtgaata aatacggcag ccggccggtg      420

gtgatagcag gaggcttatt atgctgtctt ggaatggtgt tggcctcctt tagtagcagc      480

gtggtacagc tgtacctcac tatgggattc attacaggtt taggtttagc cttcaacctg      540

caacccgcct taaccataat tggcaaatac ttctatagga agcgacccat ggcaaatgga      600

ttggccatgg caggaagtcc tgttttctta agttcattgg ctcctttcaa tcagtacctt      660

tttaatactt ttggctggaa aggaagcttc ctgattttgg gaagtctact tttgaatgcc      720

tgtgtggctg gttccctcat gagacccctt ggacccaatc aaaccacttc taagtctaaa      780

aataagactg gcaaaacaga agatgattca agcccaaaga aaatcaaaac gaagaaatca      840

acttgggaaa aagttaataa gtatttagat ttctcccttt ttaagcatag aggatttctg      900

atatatctgt ctggaaatgt cattatgttc ctaggttttt ttgcccccat tatattcttg      960

gctccatatg ctaaagacca aggaattgat gagtactcgg cagcttttct gctatctgtt     1020

atggctttcg ttgatatgtt tgctaggcct tctgtaggat taattgcaaa ctccaaatat     1080

attcgacctc gaattcagta cttcttcagt tttgcaatca tgttcaatgg agtgtgtcac     1140

ctcttgtgcc cactggcaca ggactacaca agcctggtat tatatgctgt attttttggc     1200

cttggatttg ggagtgttag cagtgttctc tttgaaactc tcatggacct cgtgggtgca     1260

ccaagatttt ccagtgccgt cggacttgtc acaattgtgg agtgtggccc agttcttctt     1320

ggccctcctc ttgcaggtaa attggtggat ttaactggag aatataaata catgtacatg     1380

tcctgtgggg ctattgtggt agcagcaagc gtgtggctgc tcattggcaa tgctatcaac     1440

tatagattgc ttgcaaagga aaggaaggag gaaaatgcaa ggcagaagac cagagaatct     1500

gaacccttga gcaaatctaa acattcggaa gatgttaacg tcaaagtttc aaatgcacag     1560

agtgtaacct cagaaagaga aactaacatt taacaagaat cacatctctg atttcagtgt     1620

ttatgacttt atctaggagt ttgtttttca ttttgttttt ttaaagtatt agaaaaggtt     1680

ttagctgaaa tgaggagtca caattaagga tggaggtgat attttcctca atggcaaatt     1740

ttaaattagt ttttaaaaac ttacttattt gggtagttaa attttgagat tatgcataga     1800

aagaatccat gctataggtt tatttccata cctgactctg ggtgtggtgg ttaaaatact     1860

aattttaaag tcttccagtg actttcggtc ttggttatat ggagaattct gaatcccaaa     1920

cccctggttt aagtaggtag aaggaggatg cctaatcata caaagtgacc ctttatacat     1980

ttcatttttt atttgatatt aaagtatgag atagagttga gagacaatta attatcccct     2040

cttacacaca aacacacata ctcccacata cttacccaca tgtacacaga gtatctggag     2100

aataaaaccc aaattcaaaa aaaaaaatga taatttattt ttaaggtaaa aataatccat     2160

gaagataaaa gaaacatatg tctgcgtgct actttacaat gttggtttta aagataagca     2220

catgggtaaa aatgagggtg atccttattc aaaaataaca tctgactact ataaaaatat     2280

ttgcatatat aagtttgaca aagaaaagaa aatcaatgtt aaaccattaa atctgagcac     2340

tgttagactt gattaatcca tgcacatgat tttttttgag tagggagcat tagtacctgg     2400

tgctagagaa tagaaccctc aaataatttt tagaattctt acctaatatg taaaagtctg     2460

catgactctt aacaatgagt cacatccatt gattttacag ggattttagt tcgtaatcca     2520

gaaagtaata atcagggatt ttattttaat caggcatcaa tccagattca ctgttatact     2580

gaaatatcaa agtaaaatcc tagttggcag gattgtaagt agaccgaatt ctaatttttc     2640

ccaacacata gtggtaattg gaggttactg ttatgaatac tccatctgac tacgactaag     2700

agagtgaggg gtggttttaa tgaaccctct aagctctctc agttccttcc cttccacaaa     2760

atgcaagagc aaaagcaaac tacaaacagg ccttgtgctc aaccactgga aatgcctcct     2820

gggataagaa tggcagcact tgaaaattct gccctctact gatgagactt cctgctgcct     2880

ttggacataa ctaagccagg aaactttaaa agccttctag aaatagaggc actgtatgac     2940

ttgcaatcgt aggtatagtt tataacctga tagcaaaaaa cttgaaatat tgcagcccag     3000

tttaattcag cactttccca ttttcataac tatgtgaaaa catctgggaa tttgaatcac     3060

tcctgaatac agaggcatat tctttttaaa ctataaatac cattttgagt gagaaagtac     3120

ttttaaacaa gaaagaaatt gtacattatg actaaagtta taaatacaat atttatatct     3180

ataaatctga agtttaacat gattaattta aaaagtattt agtgcttgac aaagtagtgt     3240

cactcttaag atgtcaaagg gaattagcca ttttttttat tgtaataaag gcaggtgcta     3300

tttttttctg gtgagattgc acctggatac caggcttttg taatagttaa cattaaacat     3360

ttgattcata aagttaattc actgcttaag catgtggctc atatttagga agctatataa     3420

aattcagttt ttcatttaac atttgctctt ttgcatatga agagatattt gtatttttca     3480

aatgttaagt aaaacaagat gtgccaatat cataggtaaa taaattaggg aaaatgtggg     3540

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                3575


<210>  155
<211>  478
<212>  PRT
<213>  homo sapiens

<400>  155

Met Pro Pro Met Pro Ser Ala Pro Pro Val His Pro Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ile Val Val Gly Ala Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ala Val Thr Val Phe Phe Lys Glu Ile Gln 
        35                  40                  45              


Gln Ile Phe His Thr Thr Tyr Ser Glu Ile Ala Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Ala Gly Gly Pro Val Ser Ser Val Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Pro Val Val Ile Ala Gly Gly Leu Leu Cys 
                85                  90                  95      


Cys Leu Gly Met Val Leu Ala Ser Phe Ser Ser Ser Val Val Gln Leu 
            100                 105                 110         


Tyr Leu Thr Met Gly Phe Ile Thr Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr Phe Tyr Arg Lys Arg Pro 
    130                 135                 140                 


Met Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Ser 
145                 150                 155                 160 


Leu Ala Pro Phe Asn Gln Tyr Leu Phe Asn Thr Phe Gly Trp Lys Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Ser Leu Leu Leu Asn Ala Cys Val Ala Gly 
            180                 185                 190         


Ser Leu Met Arg Pro Leu Gly Pro Asn Gln Thr Thr Ser Lys Ser Lys 
        195                 200                 205             


Asn Lys Thr Gly Lys Thr Glu Asp Asp Ser Ser Pro Lys Lys Ile Lys 
    210                 215                 220                 


Thr Lys Lys Ser Thr Trp Glu Lys Val Asn Lys Tyr Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Phe Lys His Arg Gly Phe Leu Ile Tyr Leu Ser Gly Asn Val Ile 
                245                 250                 255     


Met Phe Leu Gly Phe Phe Ala Pro Ile Ile Phe Leu Ala Pro Tyr Ala 
            260                 265                 270         


Lys Asp Gln Gly Ile Asp Glu Tyr Ser Ala Ala Phe Leu Leu Ser Val 
        275                 280                 285             


Met Ala Phe Val Asp Met Phe Ala Arg Pro Ser Val Gly Leu Ile Ala 
    290                 295                 300                 


Asn Ser Lys Tyr Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ser Phe Ala 
305                 310                 315                 320 


Ile Met Phe Asn Gly Val Cys His Leu Leu Cys Pro Leu Ala Gln Asp 
                325                 330                 335     


Tyr Thr Ser Leu Val Leu Tyr Ala Val Phe Phe Gly Leu Gly Phe Gly 
            340                 345                 350         


Ser Val Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Ala 
        355                 360                 365             


Pro Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Gly 
    370                 375                 380                 


Pro Val Leu Leu Gly Pro Pro Leu Ala Gly Lys Leu Val Asp Leu Thr 
385                 390                 395                 400 


Gly Glu Tyr Lys Tyr Met Tyr Met Ser Cys Gly Ala Ile Val Val Ala 
                405                 410                 415     


Ala Ser Val Trp Leu Leu Ile Gly Asn Ala Ile Asn Tyr Arg Leu Leu 
            420                 425                 430         


Ala Lys Glu Arg Lys Glu Glu Asn Ala Arg Gln Lys Thr Arg Glu Ser 
        435                 440                 445             


Glu Pro Leu Ser Lys Ser Lys His Ser Glu Asp Val Asn Val Lys Val 
    450                 455                 460                 


Ser Asn Ala Gln Ser Val Thr Ser Glu Arg Glu Thr Asn Ile 
465                 470                 475             


<210>  156
<211>  771
<212>  DNA
<213>  homo sapiens

<400>  156
agagaagcag acatcttcta gttcctcccc cactctcctc tttccggtac ctgtgagtca       60

gctaggggag ggcagctctc acccaggctg atagttcggt gacctggctt tatctactgg      120

atgagttccg ctgggagatg gaacatagca cgtttctctc tggcctggta ctggctaccc      180

ttctctcgca agtgagcccc ttcaagatac ctatagagga acttgaggac agagtgtttg      240

tgaattgcaa taccagcatc acatgggtag agggaacggt gggaacactg ctctcagaca      300

ttacaagact ggacctggga aaacgcatcc tggacccacg aggaatatat aggtgtaatg      360

ggacagatat atacaaggac aaagaatcta ccgtgcaagt tcattatcga atgtgccaga      420

gctgtgtgga gctggatcca gccaccgtgg ctggcatcat tgtcactgat gtcattgcca      480

ctctgctcct tgctttggga gtcttctgct ttgctggaca tgagactgga aggctgtctg      540

gggctgccga cacacaagct ctgttgagga atgaccaggt ctatcagccc ctccgagatc      600

gagatgatgc tcagtacagc caccttggag gaaactgggc tcggaacaag tgaacctgag      660

actggtggct tctagaagca gccattacca actgtacctt cccttcttgc tcagccaata      720

aatatatcct ctttcactca gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a               771


<210>  157
<211>  171
<212>  PRT
<213>  homo sapiens

<400>  157

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  158
<211>  6730
<212>  DNA
<213>  homo sapiens

<400>  158
gctggtggcg cccgccagcc ggcccgggag aggggacttg agcgcttcgc ggccggtgcg       60

cagcgcggct ccggccccgc agtctgtctg caagtggcca tccccgcccc cgactcctgc      120

ggccggtgcg ggagctgtca gctgcacgtt gcgggggtac cggagaagcc ggggttgcct      180

tctcccggtt ctgtgcgcta accccggagc ccggccccgg ggaactaggg agcgtctccg      240

gctgcacagc gctcaggttt tagggtttcc tttgggccac ccaaaatgtt ttttaaatac      300

tttggataag agctaaacca cctgccactg gggacttcca tactctcggc tcccttgtca      360

tctgatggca ttttgattgt ctcgaggcca agtgacttgc tgtccatgat gagtgatgag      420

aagaaccttg gtgtgtccca aaaattggta tcaccttcaa ggagcacaag tagctgctct      480

tccaagcaag gaagtcgaca ggacagctgg gaagtggtgg aaggactgag gggggagatg      540

aattacaccc aggagccacc agttcagaaa ggatttttgc tgaaaaagag gaagtggccc      600

ttaaaaggct ggcataagag attcttctat ctggacaaag gaatcttgaa atatgccaag      660

agccaaaccg atatagagag agagaagctg catggctgca ttgatgtcgg gctctcagtg      720

atgtctgtaa agaagtcatc aaaatgcata gaccttgaca ccgaggagca catctaccat      780

ctgaaggtca agtcagaaga agtctttgat gagtgggtat cgaaacttcg ccaccacaga      840

atgtatcgtc agaatgaaat tgccatgttt ccacatgaag ttaaccactt tttctcaggg      900

tccaccatca cagactcttc atctggggtg tttgactcca tttcaagtag gaagcgtagc      960

agtatatcaa agcagaattt atttcaaact ggaagcaatg tatcattttc ttgtggtggt     1020

gagacacgag ttccattatg gttacagtct tcagaggaca tggaaaaatg ctccaaagac     1080

ctggcgcact gtcatgccta cctggtagaa atgagccagc tcctgcaaag catggacgtc     1140

ctgcatcgga catactcggc accagctatc aacgccatcc agggtggatc ttttgaaagt     1200

cccaaaaagg aaaaaagatc gcacaggagg tggcggtcca gagctattgg caaagatgct     1260

aaaggaacac tgcaggtccc gaaacctttt tctggcccag taagactaca ctcctccaat     1320

cctaatttgt caacactaga ttttggagaa gagaaaaatt attctgatgg ctctgaaacc     1380

tcatcagagt tttctaaaat gcaagaagat ctgtgtcata ttgcccataa agtttacttc     1440

actttaaggt cagcttttaa tatcatgtca gcggagagag agaaactgaa gcagctgatg     1500

gagcaggatg cctcctcctc cccgtctgct caggtcattg gtctgaagaa cgccctgtca     1560

tccgccctag cacaaaacac agatcttaaa gaacgcttac gcagaatcca tgccgagtct     1620

ctgctcctcg actcccccgc tgtcgccaag tcgggtgaca atctggcaga ggaaaactcc     1680

agagatgaaa accgagctct agttcatcag ctttctaatg aaagtagact ctccatcact     1740

gactcccttt ctgagttttt tgatgctcag gaagttctgt tatctccaag ctcttcagaa     1800

aacgagattt ctgatgatga ctcatatgtc agtgacataa gtgataatct ttccttagat     1860

aatctcagta atgatttaga taatgagaga cagaccttgg ggcctgtcct tgatagtggt     1920

cgggaagcga agtcccggag aagaacgtgc ctgccggcgc cctgcccgag cagcagtaac     1980

atcagcctgt ggaacatcct gaggaacaac atcgggaagg acctgtccaa ggtggccatg     2040

ccggtggagc tgaacgagcc cctgaacacg ctgcagaggc tctgcgagga gctggagtac     2100

agcgagctcc tggacaaggc cgcgcagatt cccagccccc tggaaaggat ggtatatgtg     2160

gcagcctttg ccatatcagc gtatgcatct agctactacc gagctggaag caagccattt     2220

aatccggttc ttggagaaac atatgaatgt attcgggagg acaagggctt ccagtttttt     2280

tcagaacagg tcagccacca tccgcctatc tctgcgtgtc atgctgagtc tagaaatttt     2340

gttttctggc aagatgtgag atggaaaaac aaattctggg gcaaatccat ggaaattgtt     2400

ccaattggca caacccatgt gactctgcca gtttttgggg atcattttga gtggaacaaa     2460

gtgacctctt gcatccataa catcttaagc gggcagaggt ggattgagca ctatggagag     2520

attgtcatca agaacctgca tgatgattcc tgctactgca aagtgaattt tataaaggca     2580

aaatactgga gcactaatgc ccatgagatt gaaggcacag tgtttgacag gagtggaaaa     2640

gcggttcatc ggctgtttgg gaaatggcat gaaagcatct actgtggcgg cggctcctct     2700

tctgcctgtg tatggagagc aaatcctatg ccgaaaggct acgagcaata ctatagcttc     2760

acacagtttg cgctggaatt aaatgaaatg gatccatcat caaagtcttt attgccacct     2820

actgacactc gatttaggcc agaccagagg tttctagagg aagggaactt agaagaagct     2880

gaaatacaaa agcagaggat tgaacaactg cagagagaaa ggcggcgggt cttagaagaa     2940

aatcatgtgg agcaccagcc tcggtttttc aggaaatccg acgatgactc ttgggtgagc     3000

aacggcacct atttggaact tagaaaagat cttggttttt ccaaactgga ccatcctgtc     3060

ttatggtgaa aaagtaaaga agaaagataa cattagtgta tttctcctgt gcttgccttc     3120

tgaagtggca caaacctgtg tttatatatt taaaagatac tctaggatga tcacttgtgc     3180

ttagcttagc attgtaactc tttaagtcta tattttcctc agtgcgtttc tttacaattt     3240

caaatgttac cctgattgtt tatatgaatg tagaacacct tgacatttct ttttatatat     3300

aaactattta ataaaaatga aagattgaat gttcatgtgt gggttaaaaa aagaagcttt     3360

aacactaatt ttccaaaggt tagggaagat tccaattaaa tttatgcctt ataaaattat     3420

gttgtagaaa aaaaatcaac ctctcccagg tgcattaaga aataagaatt cccagggtta     3480

ctcacccatg cgtaagctac ccaagtttaa tttggtagct gaaatatctt tttgcctcag     3540

acagctcttg aattgctcat acagaacaat tctgctggtg ctggagtctg aagaatattt     3600

tcatttgcat tttagtggtt agggagagga tataagatta atggaatgta tatttttata     3660

taagacgtat acggcacctt cttgaaaagg aagcatttga acttgttcct ccctatagtt     3720

ctattgcctt atatgcaaaa ttgtaccctg ttgctcagag aaattattca taagagaaaa     3780

gaattccaat taattaaata tcacaatagc atcccagaga gacagtagga aatttctcct     3840

tagtgagagc tgagtccttg agaagttaag agactgtttc ctgcttccca ccccaccccg     3900

ttttttgtcc ctccgtttga tcacctccct gttgagtatg gaatgtccca gtttaatata     3960

aaacatacag tttattccac acagcagttt gactttgtaa aagtttagca aaataactga     4020

ttgttttgga taactcaaca tgtttttctt aaatgctgtt ttagtatttt ctacctctta     4080

ataagcacca tattttagat cttgtataaa aagttgccat ctgccttata gacaaatgta     4140

gagaattgat gttcttgctt tgtgttgtgt tctggtaaag ctttaagtga gtgtcttacc     4200

cctttcctat actttcttgt tatccatatc attcttttgt gagttttgca gcagtcttga     4260

ataatacaga ttataactac tgaaagggga accttcgtct ttttaaatgt gtcatttcac     4320

attacaataa tatgtgtagt agttgaattg tgttatcaaa gcatgtccaa cttctgtcca     4380

gatgacatta aaaccaaagc ctaattgtta agcctcttat tctaaagtcc atagcaatgc     4440

tatggaatat caagtataat gatgtagtaa aaagatttct ccagaaaaca ctttgagata     4500

cttaaagaaa ttcagagcat atcgaatgtt atgaatgaag agtaaaataa ttacaggaaa     4560

agaatgcatg atttttcatt gtcacaccaa ataaccagtt ggacaatatt gcattttcaa     4620

aatggagagt tatttaaagt ggatgtgtag ccttctggaa tctgcacgtg actggcattt     4680

taaaacaact cattaaatat tggattcatt ttatcgagat gccaagatga acacaatgtg     4740

aatatcattt ccatttctaa gcagttgaat gacacagtca gattctttgg tgtatgcttt     4800

gttctttcca tctcaagcat ttatccaaat tctgctcaca gacatgagga agcaggctgt     4860

agatttaagg gcactcaagg ggaaaacaaa tgtagtttcc acagtgtgag gataaatgta     4920

gaatcgtggt aatattggct gttaaattgg cctgctccag agactggctc aaaaaagaaa     4980

gaagcaacga aaacaaaatg cacagcctga atggacgtag cactgtcatg tggcatttgg     5040

aaaatcttta attatcctaa tgttatttca cttgccctta tgctttattt tagagtccca     5100

gggacaactg gatgaaacat tacgtctgta gtcatcttat ttgagatggg ggtgggaacg     5160

aattaaaata tgatagagaa ctatatgcag attttaaaat ctagtcagta ctagcatcta     5220

taaagggctt ttctgaaatt taaacagctt ggtgatgcat cctgatatta taagcttaaa     5280

actatcttga gggggaaatg acttcttttc tccttctgtc ccttttctca aaagcatctt     5340

tcccccaaat gtatgtctct aggacatttt atagttttaa gaggaagaaa acagaaacgt     5400

ggcatcattt gggaagaacc aaggtagaat ttaattttct ggactttaaa tctcctggtt     5460

aaataatgct aatcactgta ccatttgagt tacatgtttt aacctctttt ttttttctaa     5520

ttattccatc caaaatttct ggtgaattac acagaaattt ttggaaatgg gactttgtgc     5580

aggtaaccac cctgcacttc aggtaatgtt cctgtcacag ctgtcgacta ccccacgctg     5640

caggaaatcc attcagaaat gagctaacag tctccagtgt agcaggagag ccagtcactt     5700

ccctccccag gccccaaagc accccaaggc tggtattcct tgagtcatag gtattaataa     5760

taaaagcctc aatgcagctt ctccatgtag ttcctctcct acaagccagg tggattctgg     5820

tcctaactaa agagatggga gttcacctga gggcaagaag tacccaggat gcccaaacag     5880

ccgcacaggt gtcctgtgct tcctgtgaga cttcctgggg gaaatataca aactaatata     5940

ttttttaatg tttacgtcat ttacactgct gcttttctca tattctgctt ttaattactt     6000

gtagtaaatc atttgtttgg gcttcaagca ctgtcttcca tctgcatctt ccagatttat     6060

catgagtgat cttgttctac tgttaaagat gtcaagccta aaaagtaata aagtttttat     6120

ttggctgttg aaccttgatg tagcccctac tacatacact acaagttatg ccttctggct     6180

actacagaat ctccgcagac cttttagtta tgagtagaag caataagaag gtgtccttat     6240

ggtcttagga ataatagttc caatgtattg gcataatttg tttgaatgtc tttattttga     6300

tattaacacc ggcataaatc tatttttgct accagatgat agctattttc atttgctcta     6360

ttttcctctg cattgtacta atctgttact cagtgttagt cttcattttt ctgtgttgga     6420

aacctgcgtc atgtaaatat ctgcaaatca tgacagtcta aagtgcaaac cattttcaga     6480

gactttgggg aatgcagtga tcagaagtgg ctaatttatt ttatttctga ttattttatc     6540

cagagggtac ttttttaatg gatatttgta aatcttccac ttaaccactg aaaattattt     6600

tgttttaatc ccacccttcc atccatacct ctgcctcccc aaaaagctcc tattaatttg     6660

cttatccccc tcatgtagct agttgaatgt gaataaataa catggaaaaa aaaaaaaaaa     6720

aaaaaaaaaa                                                            6730


<210>  159
<211>  887
<212>  PRT
<213>  homo sapiens

<400>  159

Met Met Ser Asp Glu Lys Asn Leu Gly Val Ser Gln Lys Leu Val Ser 
1               5                   10                  15      


Pro Ser Arg Ser Thr Ser Ser Cys Ser Ser Lys Gln Gly Ser Arg Gln 
            20                  25                  30          


Asp Ser Trp Glu Val Val Glu Gly Leu Arg Gly Glu Met Asn Tyr Thr 
        35                  40                  45              


Gln Glu Pro Pro Val Gln Lys Gly Phe Leu Leu Lys Lys Arg Lys Trp 
    50                  55                  60                  


Pro Leu Lys Gly Trp His Lys Arg Phe Phe Tyr Leu Asp Lys Gly Ile 
65                  70                  75                  80  


Leu Lys Tyr Ala Lys Ser Gln Thr Asp Ile Glu Arg Glu Lys Leu His 
                85                  90                  95      


Gly Cys Ile Asp Val Gly Leu Ser Val Met Ser Val Lys Lys Ser Ser 
            100                 105                 110         


Lys Cys Ile Asp Leu Asp Thr Glu Glu His Ile Tyr His Leu Lys Val 
        115                 120                 125             


Lys Ser Glu Glu Val Phe Asp Glu Trp Val Ser Lys Leu Arg His His 
    130                 135                 140                 


Arg Met Tyr Arg Gln Asn Glu Ile Ala Met Phe Pro His Glu Val Asn 
145                 150                 155                 160 


His Phe Phe Ser Gly Ser Thr Ile Thr Asp Ser Ser Ser Gly Val Phe 
                165                 170                 175     


Asp Ser Ile Ser Ser Arg Lys Arg Ser Ser Ile Ser Lys Gln Asn Leu 
            180                 185                 190         


Phe Gln Thr Gly Ser Asn Val Ser Phe Ser Cys Gly Gly Glu Thr Arg 
        195                 200                 205             


Val Pro Leu Trp Leu Gln Ser Ser Glu Asp Met Glu Lys Cys Ser Lys 
    210                 215                 220                 


Asp Leu Ala His Cys His Ala Tyr Leu Val Glu Met Ser Gln Leu Leu 
225                 230                 235                 240 


Gln Ser Met Asp Val Leu His Arg Thr Tyr Ser Ala Pro Ala Ile Asn 
                245                 250                 255     


Ala Ile Gln Gly Gly Ser Phe Glu Ser Pro Lys Lys Glu Lys Arg Ser 
            260                 265                 270         


His Arg Arg Trp Arg Ser Arg Ala Ile Gly Lys Asp Ala Lys Gly Thr 
        275                 280                 285             


Leu Gln Val Pro Lys Pro Phe Ser Gly Pro Val Arg Leu His Ser Ser 
    290                 295                 300                 


Asn Pro Asn Leu Ser Thr Leu Asp Phe Gly Glu Glu Lys Asn Tyr Ser 
305                 310                 315                 320 


Asp Gly Ser Glu Thr Ser Ser Glu Phe Ser Lys Met Gln Glu Asp Leu 
                325                 330                 335     


Cys His Ile Ala His Lys Val Tyr Phe Thr Leu Arg Ser Ala Phe Asn 
            340                 345                 350         


Ile Met Ser Ala Glu Arg Glu Lys Leu Lys Gln Leu Met Glu Gln Asp 
        355                 360                 365             


Ala Ser Ser Ser Pro Ser Ala Gln Val Ile Gly Leu Lys Asn Ala Leu 
    370                 375                 380                 


Ser Ser Ala Leu Ala Gln Asn Thr Asp Leu Lys Glu Arg Leu Arg Arg 
385                 390                 395                 400 


Ile His Ala Glu Ser Leu Leu Leu Asp Ser Pro Ala Val Ala Lys Ser 
                405                 410                 415     


Gly Asp Asn Leu Ala Glu Glu Asn Ser Arg Asp Glu Asn Arg Ala Leu 
            420                 425                 430         


Val His Gln Leu Ser Asn Glu Ser Arg Leu Ser Ile Thr Asp Ser Leu 
        435                 440                 445             


Ser Glu Phe Phe Asp Ala Gln Glu Val Leu Leu Ser Pro Ser Ser Ser 
    450                 455                 460                 


Glu Asn Glu Ile Ser Asp Asp Asp Ser Tyr Val Ser Asp Ile Ser Asp 
465                 470                 475                 480 


Asn Leu Ser Leu Asp Asn Leu Ser Asn Asp Leu Asp Asn Glu Arg Gln 
                485                 490                 495     


Thr Leu Gly Pro Val Leu Asp Ser Gly Arg Glu Ala Lys Ser Arg Arg 
            500                 505                 510         


Arg Thr Cys Leu Pro Ala Pro Cys Pro Ser Ser Ser Asn Ile Ser Leu 
        515                 520                 525             


Trp Asn Ile Leu Arg Asn Asn Ile Gly Lys Asp Leu Ser Lys Val Ala 
    530                 535                 540                 


Met Pro Val Glu Leu Asn Glu Pro Leu Asn Thr Leu Gln Arg Leu Cys 
545                 550                 555                 560 


Glu Glu Leu Glu Tyr Ser Glu Leu Leu Asp Lys Ala Ala Gln Ile Pro 
                565                 570                 575     


Ser Pro Leu Glu Arg Met Val Tyr Val Ala Ala Phe Ala Ile Ser Ala 
            580                 585                 590         


Tyr Ala Ser Ser Tyr Tyr Arg Ala Gly Ser Lys Pro Phe Asn Pro Val 
        595                 600                 605             


Leu Gly Glu Thr Tyr Glu Cys Ile Arg Glu Asp Lys Gly Phe Gln Phe 
    610                 615                 620                 


Phe Ser Glu Gln Val Ser His His Pro Pro Ile Ser Ala Cys His Ala 
625                 630                 635                 640 


Glu Ser Arg Asn Phe Val Phe Trp Gln Asp Val Arg Trp Lys Asn Lys 
                645                 650                 655     


Phe Trp Gly Lys Ser Met Glu Ile Val Pro Ile Gly Thr Thr His Val 
            660                 665                 670         


Thr Leu Pro Val Phe Gly Asp His Phe Glu Trp Asn Lys Val Thr Ser 
        675                 680                 685             


Cys Ile His Asn Ile Leu Ser Gly Gln Arg Trp Ile Glu His Tyr Gly 
    690                 695                 700                 


Glu Ile Val Ile Lys Asn Leu His Asp Asp Ser Cys Tyr Cys Lys Val 
705                 710                 715                 720 


Asn Phe Ile Lys Ala Lys Tyr Trp Ser Thr Asn Ala His Glu Ile Glu 
                725                 730                 735     


Gly Thr Val Phe Asp Arg Ser Gly Lys Ala Val His Arg Leu Phe Gly 
            740                 745                 750         


Lys Trp His Glu Ser Ile Tyr Cys Gly Gly Gly Ser Ser Ser Ala Cys 
        755                 760                 765             


Val Trp Arg Ala Asn Pro Met Pro Lys Gly Tyr Glu Gln Tyr Tyr Ser 
    770                 775                 780                 


Phe Thr Gln Phe Ala Leu Glu Leu Asn Glu Met Asp Pro Ser Ser Lys 
785                 790                 795                 800 


Ser Leu Leu Pro Pro Thr Asp Thr Arg Phe Arg Pro Asp Gln Arg Phe 
                805                 810                 815     


Leu Glu Glu Gly Asn Leu Glu Glu Ala Glu Ile Gln Lys Gln Arg Ile 
            820                 825                 830         


Glu Gln Leu Gln Arg Glu Arg Arg Arg Val Leu Glu Glu Asn His Val 
        835                 840                 845             


Glu His Gln Pro Arg Phe Phe Arg Lys Ser Asp Asp Asp Ser Trp Val 
    850                 855                 860                 


Ser Asn Gly Thr Tyr Leu Glu Leu Arg Lys Asp Leu Gly Phe Ser Lys 
865                 870                 875                 880 


Leu Asp His Pro Val Leu Trp 
                885         


<210>  160
<211>  5472
<212>  DNA
<213>  homo sapiens

<400>  160
tggataggag agctggcgca gctgccctgg tggcagtggc tgaagtggcg gcggcttcgg       60

cggctgcggc ggctgcaaca gcttcgggct cggggttttg gcggcggcgc cggcgggcta      120

ggctgcgcgg tgcggacccc ggcgcgcggt ccgggttgct ggggcggcgc gtagatggag      180

tcttgctaca ttgcccaggc tggtcttgaa ctgctaggct caagcagttc tcccaccttg      240

acctcccaaa gcgctgagat tacagaagat gcctctaatg gaggagtttc tgagcagcac      300

ccctggccca gtggctttga aagggagctc aaaccagaga ctatttcaag ccctggatat      360

catatcctga gggccacagg agaagagaac atggctgtga gtttggatga cgacgtgccg      420

ctcatcctga ccttggatga gggtggcagt gccccactgg ctccctccaa cggcctgggc      480

caagaagagc tacctagcaa aaatggcggc agctatgcca tccacgactc ccaggccccc      540

agtctcagct ctgggggtga gagttccccc tccagccccg cacacaactg ggagatgaat      600

taccaagagg cagcaatcta cctccaggaa ggcgagaaca acgacaagtt cttcacccac      660

cccaaggatg ccaaggcgct ggcggcctac ctctttgcac acaatcacct cttctacctg      720

atggagctgg ccacggccct gctgctgctg ctgctctccc tgtgcgaggc ccccgccgtc      780

cccgcactcc ggcttggcat ctatgtccac gccaccctgg agctgtttgc cctgatggtg      840

gtagtgtttg aactctgcat gaagttacgc tggctgggcc tccacacctt catccggcac      900

aagcggacca tggtcaagac ctcggtgctg gtggtgcagt ttgtcgaggc catcgtggtg      960

ttggtacggc agatgtccca tgtgcgggtg acccgagcac tgcgctgcat tttcctggtg     1020

gactgtcggt attgcggtgg cgtccggcgc aacctgcggc agatcttcca gtccctgccg     1080

cccttcatgg acatcctcct gctgctgctg ttcttcatga tcatctttgc catcctcggt     1140

ttctacttgt tctcccctaa cccttcagac ccctacttca gcaccctgga gaacagcatc     1200

gtcagtctgt ttgtccttct gaccacagcc aatttcccag atgtgatgat gccctcctac     1260

tcccggaacc cctggtcctg cgtcttcttc atcgtgtacc tctccatcga gctgtatttc     1320

atcatgaacc tgcttctggc tgtggtgttc gacaccttca atgacattga gaaacgcaag     1380

ttcaagtctt tgctactgca caagcgaacc gctatccagc atgcctaccg cctgctcatc     1440

agccagagga ggcctgccgg catctcctac aggcagtttg aaggcctcat gcgcttctac     1500

aagccccgga tgagtgccag ggagcgctat cttaccttca aggccctgaa tcagaacaac     1560

acacccctgc tcagcctaaa ggacttttac gatatctacg aagttgctgc tttgaagtgg     1620

aaggccaaga aaaacagaga gcactggttt gatgagcttc ccaggacggc gctcctcatc     1680

ttcaaaggta ttaatatcct tgtgaagtcc aaggccttcc agtatttcat gtacttggtg     1740

gtggcagtca acggggtctg gatcctcgtg gagacattta tgctgaaagg tgggaacttc     1800

ttctccaagc acgtgccctg gagttacctc gtctttctaa ctatctatgg ggtggagctg     1860

ttcctgaagg ttgccggcct gggccctgtg gagtacttgt cttccggatg gaacttgttt     1920

gacttctccg tgacagtgtt cgccttcctg ggactgctgg cgctggccct caacatggag     1980

cccttctatt tcatcgtggt cctgcgcccc ctccagctgc tgaggttgtt taagttgaag     2040

gagcgctacc gcaacgtgct ggacaccatg ttcgagctgc tgccccggat ggccagcctg     2100

ggcctcaccc tgctcatctt ttactactcc ttcgccatcg tgggcatgga gttcttctgc     2160

gggatcgtct tccccaactg ctgcaacacg agtacagtgg cagatgccta ccgctggcgc     2220

aaccacaccg tgggcaacag gaccgtggtg gaggaaggct actattatct caataatttt     2280

gacaacatcc tcaacagctt tgtgaccctg tttgagctca cagttgtcaa caactggtac     2340

atcatcatgg aaggcgtcac ctctcagacc tcccactgga gccgcctcta cttcatgacc     2400

ttttacattg tgaccatggt ggtgatgacg atcattgtcg cctttatcct cgaggccttc     2460

gtcttccgaa tgaactacag ccgcaagaac caggactcgg aagttgatgg tggcatcacc     2520

cttgagaagg aaatctccaa agaagagctg gttgccgtcc tggagctcta ccgggaggca     2580

cggggggcct cctcggatgt caccaggctg ctggagaccc tctcccagat ggagagatac     2640

cagcaacatt ccatggtgtt tctgggacgg cgatcaagga ccaagagcga cctgagcctg     2700

aagatgtacc aggaggagat ccaggagtgg tatgaggagc atgccaggga gcaagagcag     2760

cagcgacaac tcagcagcag tgcagccccc gccgcccagc agcccccagg cagccgccag     2820

cgctcccaga ccgttaccta gcccagcgcc cgaaagccgt ctcttctatg caataacaca     2880

atagtattac tctactgcga tgtacggaac tgcggtgtgt gtacacatac tcacgtatat     2940

gcacatattt atatacagga agaaaaaaga cagacaagat ggggcttggt ttataaccac     3000

cttgccctgt cttccttaac tccagaagcc agtttggtga ggggtggggg tgcggccacc     3060

aggtctgagc tcttcctact gtggaaggct ccagaaggcc cttcacaagg agacccctca     3120

cctggatcca gtcgactgcg gggcttgccc ctcatgtggg ctggcctcca tcggccacgt     3180

ccaaagctgt cactgctact gcttcaggct cacatccccc cgacctgatg gcgtgcccgc     3240

cccctctccc tgcggcccat gccacaggtt tctgtgtttt gctttaggga cagaaccact     3300

taggaaggaa agaactcccg gtctccaggg tggtatttca gtgtctgtga taatgtcacg     3360

caacacctct tcggggacca gtgcccagga tctaatggaa gcggaattgg ggcaactggg     3420

cccatgtggc cagagctcag ttagccagtg ccgggcggcc acagattaca ctgaccaatc     3480

tcctcccttg gctctgcaag cctcccaccc agccttctct ggcttaaccc ttgttggcga     3540

aaactcttcc acagtggcct ccttggggac ccagaacccg gaggaagggg catgaggcag     3600

gaagtggggc cgatgtctgc aacccagacc acttcgtgga atgggctctt gaccaaatcc     3660

ctttttttgc gatttacccg ttcaagcaaa acaacgtttt ggttaactaa ggattgtgct     3720

aaagccgata ccaggtcctt cacacgtgtg cactaggaac aggagcgaac agcacagaga     3780

gacgctccct gtgggacgca gcagccccgt ggccccggcc cagttcccag ccaccctccc     3840

tggctctgct cacaccagag atttccatag caggagcggt tggtgcagaa gtaggttcag     3900

atgaacctca gttaacgtcg ccacccctcc tcccaccatg gtaccctgta ggagccctgt     3960

atgacatctg agcgtggtgg aggtaggagg gttgccagct gcagtgaccc tgccacagag     4020

gcagggtcag tgcagaggtc gctttggttc cgcttccctg ggccacagaa cggaacacag     4080

cataggttct gcagcaggag ccgcagtggc aggatggagg gtgcgaaggg caaggagtgc     4140

actgctgggc attcctggcc agccccggcc ctctggtgcc tgcttcctgt gacttcagaa     4200

ggcaggtgga cagagcctcc ctctggcctt gtcctcttcc cagccacaga acgggcaggg     4260

tggcacccga ccccagggga gcagtacctg gtcccccacc ccctcctccc aaccacctcc     4320

aaggccaagc tgggtcccat agccagcacg gcatggttct ccccttcccc ccttcccagg     4380

tcaggggagt tggacaagta gcaggtgttt gtttttaaag cacagccctt tgggaaagca     4440

acacattatt gagactcact gtgattcccc cgggagtcag actggctttg tcctcttcct     4500

ctctggaggg ccatgggcca tcagcaggag ctccacatcg agccccaggc cagaaccccc     4560

tccctttcac agagagggaa ctttattgca caattgggtg ccttttagct tttgtgtgtt     4620

gaaatgggcg ttttggaagc aagggtcagg ggacagcttc taaaggtgtg agtctctgac     4680

ctgagcatct gggcctcgcc tgggcccttc ttcctcccca ggggtggaaa cgtggagggg     4740

ccagcagcac cccggggtct gcccagggga gtcaaggccc cgaggtgggg gggcctattc     4800

caggaggagt gggatctcgg ccctgtccag agcgagttaa tgtgtccatc tgcccaaccc     4860

tgtcctgaga aaggacctgg ttttggccag gacctgacaa atacccaatg gcagcagtgt     4920

caacagacgg gagtccagcc agggtgggtg cccttgtcat tgaggttagg gacagctatc     4980

cccaggttat gcctggcccc acccagcagg gagttggggt ccccccacag gctgtgagct     5040

ctgtgggccc tgggatgtga tctagctcag atgccctctc atccttgatg tcatagttga     5100

gtgcacccaa gtggcaccca ctggcggcca ggggcacagc ctggtggtgg tggcaataga     5160

actgtgcccc tcctcagctc ctcgcttccc ctcccacagc cccagcctta ctccaccatg     5220

cggacaatca ttttgtacgg atcacgggag caatgctgta cggttttgta cactggtggt     5280

ttgtttccta gaaaacccat tgtgtctctg gatttctagc acattactaa aagagcctct     5340

gctttgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5460

aaaaaaaaaa aa                                                         5472


<210>  161
<211>  888
<212>  PRT
<213>  homo sapiens

<400>  161

Met Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp 
            20                  25                  30          


Ala Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe 
        35                  40                  45              


Glu Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile 
    50                  55                  60                  


Leu Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp 
65                  70                  75                  80  


Val Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala 
                85                  90                  95      


Pro Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly 
            100                 105                 110         


Ser Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly 
        115                 120                 125             


Glu Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln 
    130                 135                 140                 


Glu Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe 
145                 150                 155                 160 


Thr His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His 
                165                 170                 175     


Asn His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly 
        195                 200                 205             


Ile Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val 
    210                 215                 220                 


Phe Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile 
225                 230                 235                 240 


Arg His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe 
                245                 250                 255     


Val Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val 
            260                 265                 270         


Thr Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly 
        275                 280                 285             


Gly Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe 
    290                 295                 300                 


Met Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile 
305                 310                 315                 320 


Leu Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser 
                325                 330                 335     


Thr Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala 
            340                 345                 350         


Asn Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser 
        355                 360                 365             


Cys Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met 
    370                 375                 380                 


Asn Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Arg Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His 
                405                 410                 415     


Ala Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr 
            420                 425                 430         


Arg Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala 
        435                 440                 445             


Arg Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro 
    450                 455                 460                 


Leu Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu 
465                 470                 475                 480 


Lys Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro 
                485                 490                 495     


Arg Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser 
            500                 505                 510         


Lys Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val 
        515                 520                 525             


Trp Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser 
    530                 535                 540                 


Lys His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val 
545                 550                 555                 560 


Glu Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser 
                565                 570                 575     


Ser Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu 
            580                 585                 590         


Gly Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val 
        595                 600                 605             


Val Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg 
    610                 615                 620                 


Tyr Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val 
                645                 650                 655     


Gly Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr 
            660                 665                 670         


Ser Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn 
        675                 680                 685             


Arg Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn 
    690                 695                 700                 


Ile Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn 
705                 710                 715                 720 


Trp Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser 
                725                 730                 735     


Arg Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr 
            740                 745                 750         


Ile Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr 
        755                 760                 765             


Ser Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu 
    770                 775                 780                 


Lys Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg 
785                 790                 795                 800 


Glu Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu 
                805                 810                 815     


Ser Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg 
            820                 825                 830         


Arg Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu 
        835                 840                 845             


Ile Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg 
    850                 855                 860                 


Gln Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser 
865                 870                 875                 880 


Arg Gln Arg Ser Gln Thr Val Thr 
                885             


<210>  162
<211>  5114
<212>  DNA
<213>  homo sapiens

<400>  162
aggtggtgca acgcctggcc cggcccatcc catcccggcc acccgggcag cgggaccagg       60

cgtctggggc acagcatgcg gggcgtgtgg ccgcccccgg tgtccgccct gctgtcggcg      120

ctggggatgt cgacgtacaa gcgggccacg ctggacgagg aggacctggt ggactcgctc      180

tccgagggcg acgcataccc caacggcctg caggtgaact tccacagccc ccggagtggc      240

cagaggtgct gggctgcacg gacccaggtg gagaagcggc tggtggtgtt ggtggtactt      300

ctggcggcag gactggtggc ctgcttggca gcactgggca tccagtacca gacaagatcc      360

ccctctgtgt gcctgagcga agcttgtgtc tcagtgacca gctccatctt gagctccatg      420

gaccccacag tggacccctg ccatgacttc ttcagctacg cctgtggggg ctggatcaag      480

gccaacccag tccctgatgg ccactcacgc tgggggacct tcagcaacct ctgggaacac      540

aaccaagcaa tcatcaagca cctcctcgaa aactccacgg ccagcgtgag cgaggcagag      600

agaaaggcgc aagtatacta ccgtgcgtgc atgaacgaga ccaggatcga ggagctcagg      660

gccaaacctc taatggagtt gattgagagg ctcgggggct ggaacatcac aggtccctgg      720

gccaaggaca acttccagga caccctgcag gtggtcaccg cccactaccg cacctcaccc      780

ttcttctctg tctatgtcag tgccgattcc aagaactcca acagcaacgt gatccaggtg      840

gaccagtctg gcctgggctt gccctcgaga gactattacc tgaacaaaac tgaaaacgag      900

aaggtgctga ccggatatct gaactacatg gtccagctgg ggaagctgct gggcggcggg      960

gacgaggagg ccatccggcc ccagatgcag cagatcttgg actttgagac ggcactggcc     1020

aacatcacca tcccacagga gaagcgccgt gatgaggagc tcatctacca caaagtgacg     1080

gcagccgagc tgcagacctt ggcacccgcc atcaactggt tgccttttct caacaccatc     1140

ttctaccccg tggagatcaa tgaatccgag cctattgtgg tctatgacaa ggaatacctt     1200

gagcagatct ccactctcat caacaccacc gacagatgcc tgctcaacaa ctacatgatc     1260

tggaacctgg tgcggaaaac aagctccttc cttgaccagc gctttcagga cgccgatgag     1320

aagttcatgg aagtcatgta cgggaccaag aagacctgtc ttcctcgctg gaagttttgc     1380

gtgagtgaca cagaaaacaa cctgggcttt gcgttgggcc ccatgtttgt caaagcaacc     1440

ttcgccgagg acagcaagag catagccacc gagatcatcc tggagattaa gaaggcattt     1500

gaggaaagcc tgagcaccct gaagtggatg gatgaggaaa cccgaaaatc agccaaggaa     1560

aaggccgatg ccatctacaa catgatagga taccccaact tcatcatgga tcccaaggag     1620

ctggacaaag tgtttaatga ctacactgca gttccagacc tctactttga aaatgccatg     1680

cggtttttca acttctcatg gagggtcact gccgatcagc tcaggaaagc ccccaacaga     1740

gatcagtgga gcatgacccc gcccatggtg aacgcctact actcgcccac caagaatgag     1800

attgtgtttc cggccgggat cctgcaggca ccattctaca cacgctcctc acccaaggcc     1860

ttaaactttg gtggcatagg tgtcgtcgtg ggccatgagc tgactcatgc ttttgatgat     1920

caaggacggg agtatgacaa ggacgggaac ctccggccat ggtggaagaa ctcatccgtg     1980

gaggccttca agcgtcagac cgagtgcatg gtagagcagt acagcaacta cagcgtgaac     2040

ggggagccgg tgaacgggcg gcacaccctg ggggagaaca tcgccgacaa cgggggtctc     2100

aaggcggcct atcgggctta ccagaactgg gtgaagaaga acggggctga gcactcgctc     2160

cccaccctgg gcctcaccaa taaccagctc ttcttcctgg gctttgcaca ggtctggtgc     2220

tccgtccgca cacctgagag ctcccacgaa ggcctcatca ccgatcccca cagcccctct     2280

cgcttccggg tcatcggctc cctctccaat tccaaggagt tctcagaaca cttccgctgc     2340

ccacctggct cacccatgaa cccgcctcac aagtgcgaag tctggtaagg acgaagcgga     2400

gagagccaag acggaggagg ggaaggggct gaggacgaga cccccatcca gcctccaggg     2460

cattgctcag cccgcttggc cacccggggc cctgcttcct cacactggcg ggttttcagc     2520

cggaaccgag cccatggtgt tggctctcaa cgtgacccgc agtctgatcc cctgtgaaga     2580

gccggacatc ccaggcacac gtgtgcgcca ccttcagcag gcattcgggt gctgggctgg     2640

tggctcatca ggcctgggcc ccacactgac aagcgccaga tacgccacaa ataccactgt     2700

gtcaaatgct ttcaagatat atttttgggg aaactatttt ttaaacactg tggaatacac     2760

tggaaatctt cagggaaaaa cacatttaaa cacttttttt tttaaggaaa gaattggtat     2820

atttattatg ttctgttttt ctaaataacc tgtggacaag ggaagcccca ctgatttact     2880

ccctctcttc cccactccct gtgaggctgg gctgaggcac ggatccctgg gccacagagc     2940

aagtctccaa atcagacagc tgcctcagcc cctgggatgt gtgatttcag ctcctgtcac     3000

ctcatgcaag ggcgtggaga ccagtagagg tgtggaggcc aggcagagag aggagcctgc     3060

tctgcggggg gcccagctca tgggcactgc cccttcagct agcctgcctc cgtcccctga     3120

gtccaacagt gggagcccta gctgggaagt tctgatcccc aaagccacag caggggactg     3180

atggctatag cagaatgagg tcgggtcagg accctcaaac accatctggg aacaccaagc     3240

accctgaatc gagactgcag gagccctgcg gggtgagact gtgtcagaga tacactgctg     3300

gccacaagtg tcccctctca gtcccacctt ttcgggctgt cccatgtcta tctcaggggc     3360

ccgttacctc tctgcagcag tcccccatcc cagccacacc agggtctgtc cggccaaccc     3420

tcttccccag ggaaaggaga aaagagaaaa caggctgggc ccggtggctc actcctgtaa     3480

tcccagcact ttgggaggtt gaggtgggcg gatcacctga ggtcaggagt ttgagaccag     3540

cctggccaac gtggtgaaac cccatctcta ctaaaaaaaa ttacaaaaat tagccgggag     3600

tggtggtggg cacctgtaat cccagttact cgggaggctg aggcaagaga atctcttgag     3660

ctcaggaggc agaggttgca gtgagctgag attgcgccac tgcactccag cctgggtgac     3720

agagggagac tccgtcccaa aaaaaagaaa agagaaacag ctgtcacctc ccgcaggacc     3780

caaatcctct ctctgagcac cgtcatccac cacatggctg ggcctggctc ccaggaccag     3840

tccagtcctc tagtgcctta tctgaggctg cagccgccag tctccacccc aaggagacag     3900

cccctgctcc tagatgccct tggcctccgc agtgcagccc ccaggtgtcc tgactgaagc     3960

acaggccata gccccatttc cccggtgcct gcagggctaa cctccacggg agcccaggag     4020

ctctggccgg caggtccatg gcacagggca tcggaagact gcaaaactgc tggacttacc     4080

ctgggctgca gtccattgtc ggcccctggg ttgaatcaag atagtacttg cagctagatg     4140

gatgctttta gccaggggac attgtgaggg gaagattcct ccacccagtc tggcctgtgg     4200

tgtctgtctc ctccctgaga ccacagcttc tccagtagca gactcatggg cgccaccaag     4260

tggaagcacc tggagcggcc tctgccatcc agtggggaag ccaggccccg agacggaggt     4320

gggggcagca cgtgccctcc acagccaccg ctttcccgcc tcagcagccc aggcctcctg     4380

gcccagccct gcctggacag tgctctcccc tcacccggga agctggaatc ctcctgcccg     4440

agaggaagca gacggcacag ggacacccct gccaccttgg gatctgcctc caagctggtg     4500

cagggtatcg agagtggatt ccagatggag gtcctggtcc cagcacgcag cagtcctggt     4560

agctctgcag aggagacagg aacccgagaa gtagctgaag cagaagccag ccgcagtccc     4620

cttgccacat agaggcgggc ttctcccagc catggtgtcc cctctgcctc ccctcccccg     4680

accctcctgc cttccgcgtg gagggtggtg gtcctgtagt gtcagcacca gcaccatggg     4740

cttggacccc ctccctggac acaggcaggt gtcctagggc tgggggtgca gcccgaggga     4800

atggagacca cactcatggc tcaggtctgc cggggccggc agggggttgg ggaagaagag     4860

ggctcaggcc cagcaggggt ggaagcccct gccactgcca ctacccgctc cagagcttta     4920

aggaaaatga agtgagaccc ctccccttag gcctggggag ccatagggct ggcttctctg     4980

tgggtgcgtg gacgtggggt tgggagctgg gaatctattt tttgtattat gttttgagct     5040

actgtagttt tggcgtggca ctattgtaat ggaaataaaa tacttgtacg gagggcaaaa     5100

aaaaaaaaaa aaaa                                                       5114


<210>  163
<211>  770
<212>  PRT
<213>  homo sapiens

<400>  163

Met Arg Gly Val Trp Pro Pro Pro Val Ser Ala Leu Leu Ser Ala Leu 
1               5                   10                  15      


Gly Met Ser Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val 
            20                  25                  30          


Asp Ser Leu Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn 
        35                  40                  45              


Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln 
    50                  55                  60                  


Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu 
65                  70                  75                  80  


Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro 
                85                  90                  95      


Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu 
            100                 105                 110         


Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr 
        115                 120                 125             


Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser 
    130                 135                 140                 


Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile 
145                 150                 155                 160 


Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg 
                165                 170                 175     


Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu 
            180                 185                 190         


Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly 
        195                 200                 205             


Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu 
    210                 215                 220                 


Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr 
225                 230                 235                 240 


Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp 
                245                 250                 255     


Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr 
            260                 265                 270         


Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu 
        275                 280                 285             


Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met 
    290                 295                 300                 


Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro 
305                 310                 315                 320 


Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala 
                325                 330                 335     


Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu 
            340                 345                 350         


Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val 
        355                 360                 365             


Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr 
    370                 375                 380                 


Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg 
385                 390                 395                 400 


Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys 
                405                 410                 415     


Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp 
            420                 425                 430         


Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly 
        435                 440                 445             


Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala 
    450                 455                 460                 


Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser 
465                 470                 475                 480 


Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys 
                485                 490                 495     


Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp 
            500                 505                 510         


Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp 
        515                 520                 525             


Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val 
    530                 535                 540                 


Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met 
545                 550                 555                 560 


Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile 
                565                 570                 575     


Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser 
            580                 585                 590         


Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu 
        595                 600                 605             


Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly 
    610                 615                 620                 


Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg 
625                 630                 635                 640 


Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly 
                645                 650                 655     


Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn 
            660                 665                 670         


Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys 
        675                 680                 685             


Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln 
    690                 695                 700                 


Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro 
705                 710                 715                 720 


Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg 
                725                 730                 735     


Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His 
            740                 745                 750         


Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu 
        755                 760                 765             


Val Trp 
    770 


<210>  164
<211>  4326
<212>  DNA
<213>  homo sapiens

<400>  164
gtcagctgtg ccccggtcgc cgagtggcga ggaggtgacg gtagccgcct tcctatttcc       60

gcccggcggg cagcgctgcg gggcgagtgc cagcagagag gcgctcggtc ctccctccgc      120

cctcccgcgc cgggggcagg ccctgcctag tctgcgtctt tttcccccgc accgcggcgc      180

cgctccgcca ctcgggcacc gcaggtaggg caggaggctg gagagcctgc tgcccgcccg      240

cccgtaaaat ggtcccctcg gctggacagc tcgccctgtt cgctctgggt attgtgttgg      300

ctgcgtgcca ggccttggag aacagcacgt ccccgctgag tgcagacccg cccgtggctg      360

cagcagtggt gtcccatttt aatgactgcc cagattccca cactcagttc tgcttccatg      420

gaacctgcag gtttttggtg caggaggaca agccagcatg tgtctgccat tctgggtacg      480

ttggtgcacg ctgtgagcat gcggacctcc tggccgtggt ggctgccagc cagaagaagc      540

aggccatcac cgccttggtg gtggtctcca tcgtggccct ggctgtcctt atcatcacat      600

gtgtgctgat acactgctgc caggtccgaa aacactgtga gtggtgccgg gccctcatct      660

gccggcacga gaagcccagc gccctcctga agggaagaac cgcttgctgc cactcagaaa      720

cagtggtctg aagagcccag aggaggagtt tggccaggtg gactgtggca gatcaataaa      780

gaaaggcttc ttcaggacag cactgccaga gatgcctggg tgtgccacag accttcctac      840

ttggcctgta atcacctgtg cagccttttg tgggccttca aaactctgtc aagaactccg      900

tctgcttggg gttattcagt gtgacctaga gaagaaatca gcggaccacg atttcaagac      960

ttgttaaaaa agaactgcaa agagacggac tcctgttcac ctaggtgagg tgtgtgcagc     1020

agttggtgtc tgagtccaca tgtgtgcagt tgtcttctgc cagccatgga ttccaggcta     1080

tatatttctt tttaatgggc cacctcccca caacagaatt ctgcccaaca caggagattt     1140

ctatagttat tgttttctgt catttgccta ctggggaaga aagtgaagga ggggaaactg     1200

tttaatatca catgaagacc ctagctttaa gagaagctgt atcctctaac cacgagaccc     1260

tcaaccagcc caacatcttc catggacaca tgacattgaa gaccatccca agctatcgcc     1320

acccttggag atgatgtctt atttattaga tggataatgg ttttattttt aatctcttaa     1380

gtcaatgtaa aaagtataaa accccttcag acttctacat taatgatgta tgtgttgctg     1440

actgaaaagc tatactgatt agaaatgtct ggcctcttca agacagctaa ggcttgggaa     1500

aagtcttcca gggtgcggag atggaaccag aggctgggtt actggtagga ataaaggtag     1560

gggttcagaa atggtgccat tgaagccaca aagccggtaa atgcctcaat acgttctggg     1620

agaaaactta gcaaatccat cagcagggat ctgtcccctc tgttggggag agaggaagag     1680

tgtgtgtgtc tacacaggat aaacccaata catattgtac tgctcagtga ttaaatgggt     1740

tcacttcctc gtgagccctc ggtaagtatg tttagaaata gaacattagc cacgagccat     1800

aggcatttca ggccaaatcc atgaaagggg gaccagtcat ttattttcca ttttgttgct     1860

tggttggttt gttgctttat ttttaaaagg agaagtttaa ctttgctatt tattttcgag     1920

cactaggaaa actattccag taattttttt ttcctcattt ccattcagga tgccggcttt     1980

attaacaaaa actctaacaa gtcacctcca ctatgtgggt cttcctttcc cctcaagaga     2040

aggagcaatt gttcccctga gcatctgggt ccatctgacc catggggcct gcctgtgaga     2100

aacagtgggt cccttcaaat acatagtgga tagctcatcc ctaggaattt tcattaaaat     2160

ttggaaacag agtaatgaag aaataatata taaactcctt atgtgaggaa atgctactaa     2220

tatctgaaaa gtgaaagatt tctatgtatt aactcttaag tgcacctagc ttattacatc     2280

gtgaaaggta catttaaaat atgttaaatt ggcttgaaat tttcagagaa ttttgtcttc     2340

ccctaattct tcttccttgg tctggaagaa caatttctat gaattttctc tttatttttt     2400

tttataattc agacaattct atgacccgtg tcttcatttt tggcactctt atttaacaat     2460

gccacacctg aagcacttgg atctgttcag agctgacccc ctagcaacgt agttgacaca     2520

gctccaggtt tttaaattac taaaataagt tcaagtttac atcccttggg ccagatatgt     2580

gggttgaggc ttgactgtag catcctgctt agagaccaat caacggacac tggtttttag     2640

acctctatca atcagtagtt agcatccaag agactttgca gaggcgtagg aatgaggctg     2700

gacagatggc ggaagcagag gttccctgcg aagacttgag atttagtgtc tgtgaatgtt     2760

ctagttccta ggtccagcaa gtcacacctg ccagtgccct catccttatg cctgtaacac     2820

acatgcagtg agaggcctca catatacgcc tccctagaag tgccttccaa gtcagtcctt     2880

tggaaaccag caggtctgaa aaagaggctg catcaatgca agcctggttg gaccattgtc     2940

catgcctcag gatagaacag cctggcttat ttggggattt ttcttctaga aatcaaatga     3000

ctgataagca ttggatccct ctgccattta atggcaatgg tagtctttgg ttagctgcaa     3060

aaatactcca tttcaagtta aaaatgcatc ttctaatcca tctctgcaag ctccctgtgt     3120

ttccttgccc tttagaaaat gaattgttca ctacaattag agaatcattt aacatcctga     3180

cctggtaagc tgccacacac ctggcagtgg ggagcatcgc tgtttccaat ggctcaggag     3240

acaatgaaaa gcccccattt aaaaaaataa caaacatttt ttaaaaggcc tccaatactc     3300

ttatggagcc tggatttttc ccactgctct acaggctgtg acttttttta agcatcctga     3360

caggaaatgt tttcttctac atggaaagat agacagcagc caaccctgat ctggaagaca     3420

gggccccggc tggacacacg tggaaccaag ccagggatgg gctggccatt gtgtccccgc     3480

aggagagatg ggcagaatgg ccctagagtt cttttccctg agaaaggaga aaaagatggg     3540

attgccactc acccacccac actggtaagg gaggagaatt tgtgcttctg gagcttctca     3600

agggattgtg ttttgcaggt acagaaaact gcctgttatc ttcaagccag gttttcgagg     3660

gcacatgggt caccagttgc tttttcagtc aatttggccg ggatggacta atgaggctct     3720

aacactgctc aggagacccc tgccctctag ttggttctgg gctttgatct cttccaacct     3780

gcccagtcac agaaggagga atgactcaaa tgcccaaaac caagaacaca ttgcagaagt     3840

aagacaaaca tgtatatttt taaatgttct aacataagac ctgttctctc tagccattga     3900

tttaccaggc tttctgaaag atctagtggt tcacacagag agagagagag tactgaaaaa     3960

gcaactcctc ttcttagtct taataattta ctaaaatggt caacttttca ttatctttat     4020

tataataaac ctgatgcttt tttttagaac tccttactct gatgtctgta tatgttgcac     4080

tgaaaaggtt aatatttaat gttttaattt attttgtgtg gtaagttaat tttgatttct     4140

gtaatgtgtt aatgtgatta gcagttattt tccttaatat ctgaattata cttaaagagt     4200

agtgagcaat ataagacgca attgtgtttt tcagtaatgt gcattgttat tgagttgtac     4260

tgtaccttat ttggaaggat gaaggaatga atcttttttt cctaaatcaa aaaaaaaaaa     4320

aaaaaa                                                                4326


<210>  165
<211>  160
<212>  PRT
<213>  homo sapiens

<400>  165

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210>  166
<211>  4416
<212>  RNA
<213>  homo sapiens

<400>  166
gaagcacccc acccggcgcg gggggaaacc aggcgcccgg aagggaaggg aagggagccg       60

ggcgcgcggg cagcccgcgc ccgaccgcgc ccacggcccg gcaccgcccc ccccccacca      120

caccgaggaa aacccccgcc cccaacaaac agcaggccca cgggccgcaa accgcccggc      180

ccagcaacaa ggccggccga gagcgagagc ccagggaagg aagggagcga aagccgggag      240

gcgaaaccag cagaaaccaa cggcaaggcc gaaaacccca cgaagacaga caccaaagca      300

ggaggcacgc gcgacaagga aagcacacaa gaaagacaag gaggacacaa aaggaagcaa      360

gacaagaaac aacaaaaccc gcaaagcagc acacggagaa cacacgggag agcacaggac      420

aagaaggaaa gcccgaagag ggacacgacc caacgaaaaa agacagcaga caaaaggaca      480

accaaaccca ccacaagagg aaaaaagagg cccccgcacc aagaaagacg cagaccaggc      540

ggaggggggg ggagaacgac agggcagcca ccgccaaaga caaaaaaacg ggagaaacaa      600

acagacagag agaagacaaa cgcaagggaa gaagaaagga cagagcagcg acggaaggga      660

ccagaggaga ccgccaacag accagacagg accagggagg agcaggaaag agaagggaag      720

caagaacgcg ggaggagaca caggaaagga agggcaagaa accggggccg aagccaggca      780

gagaagcagg agacagaaaa gagagaagcg agcagagcag aaaagagcaa aaccagacca      840

aggaagagca caacaacaag acacgcgcac cgaggcaccg aagaggacca gaggcagggc      900

acaccagaag ccagggcaga gaaaaggaac accagagcac acaaaccacc gccaaggaag      960

aggcaaaacg caccccgaaa gaacacaaaa acgcagaaaa gaagaagaaa caggccccgg     1020

cagacaccgc aacagaaccc aacgaacgca cagacacaca aaacaggaag agacaaagac     1080

aggacgcagc ggggaacgaa acaaagcacg aggggaaaag ccaaaacaaa cacaccaaaa     1140

gagcacaaga acacagggag agaagccaag aagcccaaac gcaagaaacg ccccacggcc     1200

caagccacac aaagcagaag aaagacagcg aaccggaagg gcgaccaaga acaggaccaa     1260

gacaccaggc caccgcccag cacaccaggc agcccacacg accacagaac ggcaaaagaa     1320

gagaaaaacc cccaagaaca accgaaccaa aaaaacgaac cgggaagaac aaacccaagg     1380

ggccaggaac aacgcaaccc cacaaaaggg gcacgggggg cccaacaggc aaccagcccc     1440

agggcagggc aagcggcgcc aacagggggg ccccaaagac aaaaggaaca gaagacaaag     1500

ggcggagagg aagaaaaggc aaggggagaa aacaagccaa cgcaccaaag aacaagaaac     1560

aacaagccac ccaacaacaa ggggccacga cagccacagc ccgggacaag aggaacaacc     1620

aaaaacacaa cacagcgagc agccagccaa ccaaggccca aaaaaaaaaa gaaaaccagc     1680

gcacaaacag gaaaaggaaa agaccagaag acacgaagcg agaaggacaa aagcgaaggg     1740

gggggaagaa gcacgccggg agagccagga gaaaagcacc cagaaaaagc acagaccaaa     1800

gcagccacca gccccccacc ccgcagcaga agcgagaagc cgagcccgca cagcacggag     1860

aggcaagccc agcagccacc aaagaacccg ccccaaaagc aaagcgaagc acaaccaagg     1920

cagaagagcc caaaaagcga cagaaaccac cacggagaga aaaaagggga aaagagcaag     1980

cggacagaca ggcagccgaa ccaccccgaa ccaggcaaag aaaacccgcc aagaacaaga     2040

cagcccaacg caaagcaaag aaccccagga cagcacagaa acacaaagcc gaagagacaa     2100

cccccagacc aggggacaac caccaaggcc agaagagaca ccaccccaca cccaaacccc     2160

caccagaaaa cacagggacg acacagcgag gggcacaaga agagccacaa gagaacccga     2220

ccacaccaaa gcaacaggga gaaaagaaag gcaacacaca ggaccagaac aggacgccag     2280

gaagaacccg aacgcgcgca aaaaaggagc cacaaaagga cagggacaga ccagaaccag     2340

gaaagaaccc accaaggcca accccaaaaa cgcaaccaca gcacgcccag acccacaacg     2400

ggccagcgac cagaacaggc cagcaagagc gcagcgccaa aagcaaacga cgaccccagg     2460

ggcaacacca ccaacacggc agcccgcagc caagaaccac ccgaaaggac cagccaaagg     2520

aaacaggaga aagacaagaa cagccagaag gagacaaaga gaggacagaa gaccgacaca     2580

ccgcccaaaa agaaaagcgg aagacagaaa aggaagagcg gagggacaag aaccaaaaga     2640

gagcaagaga caaaaagaac acacaggaaa agacccagag gggaacgaaa aaggcaaaac     2700

acaaacacag agaacacagc gaacacggag aaaagcccac aaggacaaag ggaaagcgcc     2760

cacaccgggc accaacacag aacacgcacc cacgaagaga gaagcggaag aacggacagc     2820

acagagcagg aagaggcagg gccgaaaccc cgaagagcac gggggccagg gcgcccccac     2880

agggcgaccg gacgagagag agaggacaag ggaagaggag aagacaggaa aaagaggaag     2940

aggaggagga aaagagagga agaagcagga agaaaaagaa ggaaaaacca caaggggaga     3000

ggaagaggag gaggaggagg aagaagggaa gaagaagagg agaagaggca gagaagaggg     3060

agaagaagca aaaacgaagg cgagaaggag acagggcgaa agcaagcaag cagcaggaca     3120

aaaagaggcg agagaggagc aaggcgaaga aaagacaaag aagccaacgc agaaggaaaa     3180

aaacaagaaa gaacgcaaaa ccgccaggaa acacagaacc gagcggaccg cacacggaaa     3240

gaaaaacaaa aaaaacaaaa acaaaacaca cacacacaca cacacacaca cacacacaca     3300

cacacaaaaa aaccgggggc cgaacccaga ccagaacagc agcaaagagg aacaaggaac     3360

agcagcagaa gaaaaccaag accagagagc aacaaacaag aggaaaggaa gcgaaaagaa     3420

gcacggcaga cacagaacac cagggacaag cgacaaggga gaaaaaaagg aaacaagcaa     3480

accgccagaa agaaaaggag aaccgcacac aaaaccccac agagaagaaa gagccaaccc     3540

ggcaacacca aaacagcaga aggagaacaa aagagcagag agcgaacaaa aggagagcca     3600

agaaagcagc gaagaagaac gaagcaccac gggaaaagga gcaaaagagc cagagcgagc     3660

agggacaaca agaacgaaag gacagcaaaa cacagaacag gggagggaaa gggaacaaga     3720

aggaagacag aagcgacccg gccaagcaag accgggcgaa ggccaccaga caaggccaac     3780

ccgcccacca aggggccaca aaacagcagg agccgacaaa acccaaaaaa acaaaaccac     3840

gaccgcagag aaacgaaaca cgggacacac ccaacccgga gaaggagaca gaaccacaga     3900

aacgaaaggg aaacaacgca ccagacgcac agacaggaca gcagaggcca aacgccaaag     3960

agaaggaccc aaaaacaaca agcgaaccac agaaacagaa gacggcaaca gacgagccaa     4020

accggcagaa aaccccacga caagacagag aaaacaaagg caaacaaaca caggaggaaa     4080

acgaggaaaa caaaaaaaga gaaaaggaaa ggaaagaaaa gagagagcaa ggcccgcaga     4140

gagaaacagg agaacaaacg ccggacgaga acagaacaaa gggaagaaga caacacaaca     4200

agcaaccacc cagaaaaaaa caaagaaaca cgggacaaag cagagccgca gaaagaaaca     4260

gccaaccaac aacccaccag aagccaaaag gaaaccaaaa cagggggaac aagaacaggc     4320

caagccgaca gagaagacag acgacccaaa gccgacacag gcacagacca gaccccacca     4380

caaaaaagca caacaagcca aaaaaaaaaa aaaaaa                               4416


<210>  167
<211>  4455
<212>  DNA
<213>  homo sapiens

<400>  167
gcggccgccg cgccgcgcac ccatggacgg cccggccatc atcacccagg tgaccaaccc       60

caaggaggac gagggccggt tgccgggcgc gggcgagaaa gcctcccagt gcaacgtcag      120

cttaaagaag cagaggagcc gcagcatcct tagctccttc ttctgctgct tccgtgatta      180

caatgtggag gcccctccac ccagcagccc cagtgtgctt ccgccactgg tggaggagaa      240

tggtgggctt cagaagggtg accagaggca ggtcattccc ataccaagtc caccagctaa      300

gtaccttctt ccagaggtga cggtgcttga ctatggaaag aaatgtgtgg tcattgattt      360

agatgaaaca ttggtgcaca gttcgtttaa gcctattagt aatgctgatt ttattgttcc      420

ggttgaaatc gatggaacta tacatcaggt gtatgtgctg aagcggccac atgtggacga      480

gttcctccag aggatggggc agctttttga atgtgtgctc tttactgcca gcttggccaa      540

gtatgcagac cctgtggctg acctcctaga ccgctggggt gtgttccggg cccggctctt      600

cagagaatca tgtgtttttc atcgtgggaa ctacgtgaag gacctgagtc gccttgggcg      660

ggagctgagc aaagtgatca ttgttgacaa ttcccctgcc tcatacatct tccatcctga      720

gaatgcagtg cctgtgcagt cctggttcga tgacatgacg gacacggagc tgctggacct      780

catccccttc tttgagggcc tgagccggga ggacgacgtg tacagcatgc tgcacagact      840

ctgcaatagg tagccctggc ctctgcctgc ctcccgcctg tgcactctgg aacctctggc      900

ctcaggggac ctgcctgtcc tcagctccct gggagctgaa agtgaggata ctccgtgctc      960

caggccacag ggtgaatgtg gccatgccta cctgttttgt ttttttaaga acagaaacaa     1020

ctattttaaa agaactcttt taagaaattt cataaaggga catgcatttt actgggtttg     1080

cttttcttaa aacataccaa aaaagaaaaa aatagaaaaa aaaaaaaaaa aagcttgatc     1140

tctatcagac ttcctttcaa ctgtcctccc ctccaagcag accacctgtc cccttctatc     1200

ccagctcaga gcagctgacc caactcagaa tctctttcct acaggatgaa gtgccttttg     1260

aatgttattt taagccgaga gttaattttt ctacacaaca tatttccaga catcttttag     1320

tcttttattg tcttagatac tataagaaga tgaacatgac aattttctag aacctggtag     1380

cgtgtgtgtg tgtggcgggg ggtgctgagg gaggggagtg agtcacagga gcctgtcccc     1440

caacaggtgt gactgctctg acaacctgtg gcatgctgca gggtcaggct cctgatagga     1500

ggatttcatg actatgtcat tgtctccact catttttgac ccagtttgga atgtatctgc     1560

aattgtgtgg ctcaacactt taggaaacaa tagattattt tatattatta tttctgatgg     1620

tgacaagttt gtcttgaggt cacattttct ccttgaaaag tgacatcctg tcacttctgc     1680

tctcacacta ctgccataca tttgtgtttt ttgttgttat tgtttgggta gagcagttac     1740

aagaaaccct aaaacccttg gatataaaag aaatctgttt attgattttt aaatctttcc     1800

tttccaaaag ctggatacac atggagctgt ttgggaattt tccttgctgc taccgcgctg     1860

ccaccaaatg gaattgacca gcggctgtta cactgttctt tgccactgtg cctatgctca     1920

gaatatgctc actgctaagc tacaaactcg gacagggtca gaaacagagg tgtcccatcc     1980

cattgcagcc tccaccacct gtaacccctt cctggcattg gccactgaag ggtacaaagg     2040

caaaaggacc acagcaccac ttaggtgtag catggatttt aaactgcagt cagtatcaga     2100

tcctgtttga taaataagct gactgttctc tcttgagaac ctgtggcctc aaccagccac     2160

caagctgatg tggcccaagt ccatctcttg gtcttctcct ttgaagcaca gcctatttct     2220

gagccaaggg ttggggaagc ctgtctagat gtgggactca ttgccccaaa ccagggagag     2280

gaagagctcc cacagggaga gcccaggctc tctttgcagc ctttcccagt ttggtgttta     2340

agcagtgcca tgttccttgt ttgacaacaa gacagtctgt aaagtattgc tcttaaaaac     2400

aattaaaaag aaccctttca tattggcacc attgccttag tcctctgtgg gttggtcttc     2460

agccagcatt ctggtgggag tgactggcat taacaagact ggaaatcggg ggtcaaagta     2520

aaatatcttt gttttgcttt cattcacaaa gtaatgaagc cagctgccaa ttacatcctc     2580

ccaacagcac tttggtctgt ggactgctgt gtgaatattc agaagggaag taagtattca     2640

gggggtaaac aggtctccca gcattctgag tgttccaaac cagtaatcca catgccaatt     2700

caaatagaac agccccttgc tagatattac cacagataat gacagttaca tggtagaact     2760

gcccatgcca caaatattta tttggaaaag tagtcattaa atgaacccac tgccttaaat     2820

gtcttgaatg ttgcagtcaa gtgtctgtca tgtgttgata tccacacaga attaggccct     2880

aatgagagcc ttagaccctc aaccatgccc ccttcgttgg catcacaggg ccttatttgg     2940

aagagcgggc aaagaggatg gaaatcataa aatatttcat gggaatcgaa cctagggata     3000

gtgctccact tctgacgatg gagtgaagac acttggcaga cttgagccag acacttcacc     3060

tagtagttcc tgaaactgtg agcaccactg cactaagcca gtgcggagct gttagggacg     3120

ggcccagctc ctgcaccacg gacacagaat gtctggagag ggccagcagg ccctctgagg     3180

gttctggaat ctgtgcacct tatttgacca cactccaaaa ttctgttttt attttaaccc     3240

ttgaatctgc tttatgtaca taatcaaaat atctatatct atatctatat ctatatctat     3300

atatttttaa tcatctacat gtaaatgaag caatagaatt ctaacataag gccaagaaat     3360

gagacgaatg tttggggttt atgtttttta aggtaaatac gggtattgtt tttaattatt     3420

accatgtatt aaattgtggg ctttgaaacc taatgaaacc tgttagccac ttctctgtgc     3480

catatacttc ccatgttacc aaaatacccc caactcttta gccaaaagag aaccctgacc     3540

tcctgagttt ccatgctcct ttctgtacca ggtttaaatg tagtcttctg gagaagtatt     3600

tttgacattg agctctggga caggacacct tgggtttgtg gactgcagcc cactatgatg     3660

ttattacttc tctggccagg cctccagtgg aagtgcacag gcactcccaa tgttgttaat     3720

gctctgtctt ccatttgttc tggaatccta cgtgttggtc tgtggttcca tgcattagct     3780

gtttgtaaat aatgcatttg catactgaaa aaggaatgcc acctgccaca gttgatggtg     3840

aggaagctcc tttgacgtgg tgcaattttg atgagatgtc tctggggaca cgaggatgcc     3900

ctaatgatgc tgacttgtca tggttgcagc atttgaactt ttggtgttaa aaaaaaaaac     3960

ctgtaagtct gtaacctggc aacattttac aaccctgtat ttttaaagat ggctttctaa     4020

taaaaaatcc agaaccacac agccctatgg tcaaacaatc ctacgtttgt gcctctgctt     4080

ttaaaggtgc tgtgctggac agttggcatg ccagggttcg agaagagtga atggcttgac     4140

gtacttgcag ttaactgtgc aaaattggct ggctgcctct gttcctactg tactgtaact     4200

ttgatcatgt ctgttcctgt tccattctcc caggagcttc tctgcagact gacacaccct     4260

cccccacccc gggtagtgga gatgctggtg tctgggtagt catggatttc tgctggacat     4320

ttgaatgtga taaacaatcc agcattactt aggaaatgct acatgcggaa tgtgcacgtt     4380

tccaggggcg agtattgtca atcaaaaggt ttgcaatgat ttccttcctg ccaaaaataa     4440

acatgtgaaa ctgca                                                      4455


<210>  168
<211>  276
<212>  PRT
<213>  homo sapiens

<400>  168

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Gly Asp 
65                  70                  75                  80  


Gln Arg Gln Val Ile Pro Ile Pro Ser Pro Pro Ala Lys Tyr Leu Leu 
                85                  90                  95      


Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys Cys Val Val Ile Asp 
            100                 105                 110         


Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Ile Ser Asn Ala 
        115                 120                 125             


Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr Ile His Gln Val Tyr 
    130                 135                 140                 


Val Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Gln 
145                 150                 155                 160 


Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp 
                165                 170                 175     


Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val Phe Arg Ala Arg Leu 
            180                 185                 190         


Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu 
        195                 200                 205             


Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile Ile Val Asp Asn Ser 
    210                 215                 220                 


Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala Val Pro Val Gln Ser 
225                 230                 235                 240 


Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu Asp Leu Ile Pro Phe 
                245                 250                 255     


Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr Ser Met Leu His Arg 
            260                 265                 270         


Leu Cys Asn Arg 
        275     


<210>  169
<211>  3571
<212>  DNA
<213>  homo sapiens

<400>  169
gcggggctga ccaggccggt cccccgggaa caggaaccct ggtggacggg tcccagcagg       60

cttcttcggt gcccgagagg gagcgggtgc ccaagggggt ggtccctgtg gcaggtcccg      120

gggtgggggc gcggcgctcc gggaagagcc ttccgcaggt ccccgccccg tcacgtgggc      180

gccggccccg gccgctgcgg tcggtccgct ggttggtcgg gcgcttggtc cggcagttgg      240

tcggtgggcc agtggcccgt cgctcgcttc tgggctctca tgtttgaagg tgggagggac      300

acgggagcgg cccgcacacc tgagccgccc ggagaggagc ctcggccccg tacccagtaa      360

gaagaggagg aggccaggca ggcaaaagga gtcatggctt ctgatgctag tcatgcgctg      420

gaagctgccc tggagcaaat ggacgggatc attgcaggca ctaaaacagg tgcagatctt      480

agtgatggta cttgtgagcc tggactggct tccccggcct cctacatgaa ccccttcccg      540

gtgctccatc tcatcgagga cttgaggctg gccttggaga tgctggagct tcctcaggag      600

agagcagccc tcctgagcca gatccctggc ccaacagctg cctacataaa ggaatggttt      660

gaagagagct tgtcccaggt aaaccaccac agtgctgcta gtaatgaaac ctaccaggaa      720

cgcttggcac gtctagaagg ggataaggag tccctcatat tgcaggtgag tgtcctcaca      780

gaccaagtag aagcccaggg agaaaagatt cgagacctgg aagtgtgtct ggaaggacac      840

caggtgaaac tcaatgctgc tgaagagatg cttcaacagg agctgctaag ccgcacatct      900

cttgagaccc agaagctcga tctgatgact gaagtgtctg agctgaagct caagctggtt      960

ggcatggaga aggagcagag agagcaggag gagaagcaga gaaaagcaga ggagttactg     1020

caagagctca ggcacctcaa aatcaaagtg gaagagttgg aaaatgaaag gaatcagtat     1080

gaatggaagc taaaggccac taaggctgaa gtcgcccagc tgcaagaaca ggtggccctg     1140

aaagatgcag aaattgagcg tctgcacagc cagctctccc ggacagcagc tctccacagt     1200

gagagtcaca cagagagaga ccaagaaatt caacgtctga aaatggggat ggaaactttg     1260

ctgcttgcca atgaagataa ggaccgtcgg atagaggagc ttacggggct gttaaaccag     1320

taccggaagg taaaggagat tgtgatggtc actcaagggc cttcggagag aactctctca     1380

atcaatgaag aagaaccgga gggaggtttc agcaagtgga acgctacaaa taaggaccct     1440

gaagaattat ttaaacaaga gatgcctcca agatgtagct ctcctacagt ggggccacct     1500

ccattgccac agaaatcact ggaaaccagg gctcagaaaa agctctcttg tagtctagaa     1560

gacttgagaa gtgaatctgt ggataagtgt atggatggga accagccctt cccggtgtta     1620

gaacccaagg acagcccttt cttggcggag cacaaatatc ccactttacc tgggaagctt     1680

tcaggagcca cgcccaatgg agaggctgcc aaatctcctc ccaccatctg ccagcctgac     1740

gccacgggga gcagcctgct gaggctgaga gacacagaaa gtggctggga cgacactgct     1800

gtggtcaatg acctctcatc cacatcatcg ggcactgaat caggtcctca gtctcctctg     1860

acaccagatg gtaaacggaa tcccaaaggc attaagaagt tctggggaaa aatccgaaga     1920

actcagtcag gaaatttcta cactgacacg ctggggatgg cagagtttcg acgaggtggg     1980

ctccgggcaa ccgcagggcc aagactctct aggaccaggg actccaaggg acagaaaagt     2040

gacgccaatg ccccctttgc ccagtggagc acagagcgtg tgtgtgcatg gctggaggac     2100

tttggcctgg ctcagtatgt gatctttgcc aggcagtggg tatcttctgg ccacacctta     2160

ttgacagcca cccctcagga catggaaaag gagctaggaa ttaagcaccc actccacagg     2220

aagaagcttg ttttagcagt gaaagccatc aacaccaaac aggaggagaa gtctgcactg     2280

ctagaccaca tttgggtgac aaggtggctt gatgatattg gcttacccca gtacaaagac     2340

cagtttcatg aatctagagt tgacggacga atgctgcaat acctaactgt gaacgattta     2400

ctcttcttaa aagtcaccag ccaactacat catctcagca tcaaatgtgc cattcacgtg     2460

ctgcatgtca acaagttcaa cccccactgc ctgcaccggc ggccagctga tgagagtaac     2520

ctttctcctt cagaagttgt acagtggtcc aaccacaggg tgatggagtg gttacgatct     2580

gtggacctgg cagagtatgc acccaatctt cgagggagtg gagtccatgg aggcctcatt     2640

atcctggagc cacgcttcac tggggacacc ctggctatgc ttctcaacat ccccccacaa     2700

aagacgctcc tcaggcgcca cctgaccacc aagttcaatg ccttgattgg tccggaggct     2760

gaacaggaga agcgagagaa aatggcctca ccagcttaca caccactgac caccacagcc     2820

aaagtccggc caaggaaact aggattttca cacttcggaa acataagaaa aaagaagttc     2880

gatgaatcga cggactacat ttgcccaatg gagcccagtg acggtgtcag tgatagtcac     2940

agggtctaca gtggctaccg gggcctcagc ccccttgatg cccctgaact ggatgggctg     3000

gaccaggtgg gacagattag ctgatgccct tgtcacctgc cctctgtgca ccctgagagc     3060

tcacagtaac actgtgtgtg tcaccatata actgcacctc acccccgcac gtgtgcatga     3120

ctcgcagaga atattccagc aattgtgtac ccctgggcca gtctctttga accctgaggg     3180

tggccaggat ctggagctgc atctctaagg ggccaggctt tggggaccat tgccaaaggt     3240

ggactcagga ggaaagacac ttaaagacac ttttacatgt ctagtaattc ttgatgttca     3300

tcttcagcac cagtggaaac acatgaactt cgatgcaggt ccagagacca tggacactcc     3360

cacgaggctc agctctcagg caccccctac acttcagttg agggaaaagc tcaagtgcct     3420

taggcccgtg gaccacagtc ttggctgaga tcaaagggat gagcaacagg gacttctgcc     3480

acagtgacaa tggaattgtg ttgtgcctta cttcagaggt ggtctcttct ttcttgtaat     3540

aaaagcaata tttatgcgga aagcaagcag c                                    3571


<210>  170
<211>  876
<212>  PRT
<213>  homo sapiens

<400>  170

Met Ala Ser Asp Ala Ser His Ala Leu Glu Ala Ala Leu Glu Gln Met 
1               5                   10                  15      


Asp Gly Ile Ile Ala Gly Thr Lys Thr Gly Ala Asp Leu Ser Asp Gly 
            20                  25                  30          


Thr Cys Glu Pro Gly Leu Ala Ser Pro Ala Ser Tyr Met Asn Pro Phe 
        35                  40                  45              


Pro Val Leu His Leu Ile Glu Asp Leu Arg Leu Ala Leu Glu Met Leu 
    50                  55                  60                  


Glu Leu Pro Gln Glu Arg Ala Ala Leu Leu Ser Gln Ile Pro Gly Pro 
65                  70                  75                  80  


Thr Ala Ala Tyr Ile Lys Glu Trp Phe Glu Glu Ser Leu Ser Gln Val 
                85                  90                  95      


Asn His His Ser Ala Ala Ser Asn Glu Thr Tyr Gln Glu Arg Leu Ala 
            100                 105                 110         


Arg Leu Glu Gly Asp Lys Glu Ser Leu Ile Leu Gln Val Ser Val Leu 
        115                 120                 125             


Thr Asp Gln Val Glu Ala Gln Gly Glu Lys Ile Arg Asp Leu Glu Val 
    130                 135                 140                 


Cys Leu Glu Gly His Gln Val Lys Leu Asn Ala Ala Glu Glu Met Leu 
145                 150                 155                 160 


Gln Gln Glu Leu Leu Ser Arg Thr Ser Leu Glu Thr Gln Lys Leu Asp 
                165                 170                 175     


Leu Met Thr Glu Val Ser Glu Leu Lys Leu Lys Leu Val Gly Met Glu 
            180                 185                 190         


Lys Glu Gln Arg Glu Gln Glu Glu Lys Gln Arg Lys Ala Glu Glu Leu 
        195                 200                 205             


Leu Gln Glu Leu Arg His Leu Lys Ile Lys Val Glu Glu Leu Glu Asn 
    210                 215                 220                 


Glu Arg Asn Gln Tyr Glu Trp Lys Leu Lys Ala Thr Lys Ala Glu Val 
225                 230                 235                 240 


Ala Gln Leu Gln Glu Gln Val Ala Leu Lys Asp Ala Glu Ile Glu Arg 
                245                 250                 255     


Leu His Ser Gln Leu Ser Arg Thr Ala Ala Leu His Ser Glu Ser His 
            260                 265                 270         


Thr Glu Arg Asp Gln Glu Ile Gln Arg Leu Lys Met Gly Met Glu Thr 
        275                 280                 285             


Leu Leu Leu Ala Asn Glu Asp Lys Asp Arg Arg Ile Glu Glu Leu Thr 
    290                 295                 300                 


Gly Leu Leu Asn Gln Tyr Arg Lys Val Lys Glu Ile Val Met Val Thr 
305                 310                 315                 320 


Gln Gly Pro Ser Glu Arg Thr Leu Ser Ile Asn Glu Glu Glu Pro Glu 
                325                 330                 335     


Gly Gly Phe Ser Lys Trp Asn Ala Thr Asn Lys Asp Pro Glu Glu Leu 
            340                 345                 350         


Phe Lys Gln Glu Met Pro Pro Arg Cys Ser Ser Pro Thr Val Gly Pro 
        355                 360                 365             


Pro Pro Leu Pro Gln Lys Ser Leu Glu Thr Arg Ala Gln Lys Lys Leu 
    370                 375                 380                 


Ser Cys Ser Leu Glu Asp Leu Arg Ser Glu Ser Val Asp Lys Cys Met 
385                 390                 395                 400 


Asp Gly Asn Gln Pro Phe Pro Val Leu Glu Pro Lys Asp Ser Pro Phe 
                405                 410                 415     


Leu Ala Glu His Lys Tyr Pro Thr Leu Pro Gly Lys Leu Ser Gly Ala 
            420                 425                 430         


Thr Pro Asn Gly Glu Ala Ala Lys Ser Pro Pro Thr Ile Cys Gln Pro 
        435                 440                 445             


Asp Ala Thr Gly Ser Ser Leu Leu Arg Leu Arg Asp Thr Glu Ser Gly 
    450                 455                 460                 


Trp Asp Asp Thr Ala Val Val Asn Asp Leu Ser Ser Thr Ser Ser Gly 
465                 470                 475                 480 


Thr Glu Ser Gly Pro Gln Ser Pro Leu Thr Pro Asp Gly Lys Arg Asn 
                485                 490                 495     


Pro Lys Gly Ile Lys Lys Phe Trp Gly Lys Ile Arg Arg Thr Gln Ser 
            500                 505                 510         


Gly Asn Phe Tyr Thr Asp Thr Leu Gly Met Ala Glu Phe Arg Arg Gly 
        515                 520                 525             


Gly Leu Arg Ala Thr Ala Gly Pro Arg Leu Ser Arg Thr Arg Asp Ser 
    530                 535                 540                 


Lys Gly Gln Lys Ser Asp Ala Asn Ala Pro Phe Ala Gln Trp Ser Thr 
545                 550                 555                 560 


Glu Arg Val Cys Ala Trp Leu Glu Asp Phe Gly Leu Ala Gln Tyr Val 
                565                 570                 575     


Ile Phe Ala Arg Gln Trp Val Ser Ser Gly His Thr Leu Leu Thr Ala 
            580                 585                 590         


Thr Pro Gln Asp Met Glu Lys Glu Leu Gly Ile Lys His Pro Leu His 
        595                 600                 605             


Arg Lys Lys Leu Val Leu Ala Val Lys Ala Ile Asn Thr Lys Gln Glu 
    610                 615                 620                 


Glu Lys Ser Ala Leu Leu Asp His Ile Trp Val Thr Arg Trp Leu Asp 
625                 630                 635                 640 


Asp Ile Gly Leu Pro Gln Tyr Lys Asp Gln Phe His Glu Ser Arg Val 
                645                 650                 655     


Asp Gly Arg Met Leu Gln Tyr Leu Thr Val Asn Asp Leu Leu Phe Leu 
            660                 665                 670         


Lys Val Thr Ser Gln Leu His His Leu Ser Ile Lys Cys Ala Ile His 
        675                 680                 685             


Val Leu His Val Asn Lys Phe Asn Pro His Cys Leu His Arg Arg Pro 
    690                 695                 700                 


Ala Asp Glu Ser Asn Leu Ser Pro Ser Glu Val Val Gln Trp Ser Asn 
705                 710                 715                 720 


His Arg Val Met Glu Trp Leu Arg Ser Val Asp Leu Ala Glu Tyr Ala 
                725                 730                 735     


Pro Asn Leu Arg Gly Ser Gly Val His Gly Gly Leu Ile Ile Leu Glu 
            740                 745                 750         


Pro Arg Phe Thr Gly Asp Thr Leu Ala Met Leu Leu Asn Ile Pro Pro 
        755                 760                 765             


Gln Lys Thr Leu Leu Arg Arg His Leu Thr Thr Lys Phe Asn Ala Leu 
    770                 775                 780                 


Ile Gly Pro Glu Ala Glu Gln Glu Lys Arg Glu Lys Met Ala Ser Pro 
785                 790                 795                 800 


Ala Tyr Thr Pro Leu Thr Thr Thr Ala Lys Val Arg Pro Arg Lys Leu 
                805                 810                 815     


Gly Phe Ser His Phe Gly Asn Ile Arg Lys Lys Lys Phe Asp Glu Ser 
            820                 825                 830         


Thr Asp Tyr Ile Cys Pro Met Glu Pro Ser Asp Gly Val Ser Asp Ser 
        835                 840                 845             


His Arg Val Tyr Ser Gly Tyr Arg Gly Leu Ser Pro Leu Asp Ala Pro 
    850                 855                 860                 


Glu Leu Asp Gly Leu Asp Gln Val Gly Gln Ile Ser 
865                 870                 875     


<210>  171
<211>  3258
<212>  DNA
<213>  homo sapiens

<400>  171
ctgtattgtg gttcctggaa cacttcagag gcttgtgatt ctactgcttc ttattcacac       60

tataatacat gtctcaccaa tagatgattc aagaacatca tttaaataca caatttttca      120

ttctctattt ttgctaaatt tcttcatact caactttcag attctttaat ctccagctca      180

gcttcaacaa ttcaacgctg ttctttctga aaaagtacac atcgtgcctt ctctacttcg      240

ctcttggaac ataatttctc atggcagtgt ttaagaccac tctgtggagg ttaatttctg      300

ggaccttagg gataatatgc ctttcgttga tggctacgtt gggaattttg ttgaaaaatt      360

cttttactaa actgagtatt gagccagcat ttactccagg acccaacata gaactccaga      420

aagactctga ctgctgttct tgccaagaaa aatgggttgg gtaccggtgc aactgttact      480

tcatttccag tgaacagaaa acttggaacg aaagtcggca tctctgtgct tctcagaaat      540

ccagcctgct tcagcttcaa aacacagatg aactggattt tatgagctcc agtcaacaat      600

tttactggat tggactctct tacagtgagg agcacaccgc ctggttgtgg gagaatggct      660

ctgcactctc ccagtatcta tttccatcat ttgaaacttt taatacaaag aactgcatag      720

cgtataatcc aaatggaaat gctttagatg aatcctgtga agataaaaat cgttatatct      780

gtaagcaaca gctcatttaa atgtttcttg gggcagagaa ggtggagagt aaagacccaa      840

cattactaac aatgatacag ttgcatgtta tattattact aattgtctac ttctggagtc      900

tataaaatgt ttttaaacag tgtcatatac aattgtcatg tatgtgaaac aatgtgtttt      960

aaaattgatg aaattcgttc acctacattt gagaattata aaattaacat aaagaatttt     1020

gtattttcat ttaatgtata tatttaatgt taaattcaat gtagttttat tacacattta     1080

tgtaatttta tttacattct tgctaattct cagcagaaat ttaaataaga tttaattcac     1140

atcaaataaa atttagaaaa taaaatttaa ctcacactgc ccaggctgga gcatagtggc     1200

aagatcatag ctcattgcaa gctcaagtga tcctcctgac tcagcctccc aagtagctag     1260

gactgcaggc accatgtcac tatgcccgac taatttttaa tttttaattt tttgtcaaga     1320

caaggtcttg ctatgttgcc caggctggtc ttgaactcct ggcctcaagg gattctccca     1380

ccttggattc ccaaagtgct gggattatag gtgtgaacca ccatccctgg ccctcttcac     1440

attcttgtat gaagattgat ttgggaaaaa tgcatttcag gtaactgaca aaagatatag     1500

gatgaaaaat aatatctttc aaatgtttaa tttgaactaa gagagcttat gcattgcact     1560

ttctggagat ttgtaatgtt ttggttttgt tgtccatgtg actacaaaat aatatatttt     1620

ttaattaaaa aatttaaaat aatacaggca agcatgtaat gattatcaat atttttttcc     1680

accaactatc ctatacccct gacctccttt cattaggcat tatcttctgt tttgatttta     1740

acacttagag tggttttctc tgttatgaat caaagctgat ctattttcat catttttgtg     1800

atgaaaaaat taattttgat tgacttagga tggaaggatt tggactgggt gtggtggttt     1860

atgcctgtaa tcgcagcact ttgggaggcc aaggcgggtg gatcacttga ggtcaggagt     1920

ttgagaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac aaaaattggc     1980

tgggtgtggt agtgcacacc tgtaatccca gctatttggg aggctgagtc gagaggatcg     2040

cttgaaccta ggaggtggag gttgcagtga gtcgagattg caccactgca ctccagcctg     2100

ggtgacagag ccagactcct ctccaaaaaa aaaaaaaaaa aaaaaagatg aaaggatttg     2160

gaaccttaat tgcatctgaa aaactgcctc acctttgtta tttagtgtac tccaaccacg     2220

gagtaacatc ccatcataat cccaaatcct actcaaacaa aaggggaagg gattatgcag     2280

gtgtacacta ggccactggt gtaccaatta gaaaccactt tagagttatg cctactgtac     2340

ccacataatc ctaaaaatat gttacaactg ctacttcata gtttatgcca cttattttat     2400

tttttacttt tattattttt ttttctgaga cacggtttca ttcccattgc ccaggctgta     2460

gtgcaatgat gcaatcatgg ttcactgcag cttcaacttc ccaggctcaa gggatcctcc     2520

cacctcagcc ttctgagtac ttgggactca ggtgcgagcc atcatgctca gctaattttt     2580

tgtatcattt gtagaaatgg ggttttgtat tgttgcccag gctgatcttg aactcctggg     2640

gtcaaggatt ctgcccgcct tggcctccta aagggctgga attacaggca taagccactg     2700

tgcccggcca gtttatataa tttaaacact gccttttggt tccttgattc ccatatgcta     2760

ggacaagtaa ttattatttt attttatttt actttaagtt ctgggttaca tgtgcagaac     2820

ctgcaggttt gttacatagg tatacatgtt ccaaggtggt ttgctgcacc tattgaccca     2880

tcatctaggt tttaagtccc acatgcatta ggtatttgtc ctaatgctct tcctcccctt     2940

gccccccacc ccccgacagg ccttggtctg tgatgttcac ctccctgtgt ccatgtgttc     3000

tcattgttca actcccactt attagtaaga acatgtggtg tttggttttc tgttcctgtg     3060

ttagtttgct gagaatgatg gtttccagct tcatccatgt cgctgcaaag gacatgaact     3120

cattcttttt atggctgcat agtattccat ggtgtatatg tgccatattt tctttatcca     3180

gtctatcact gatgggcatt tgggttggtt ccaagtcttt gctatggtaa atagtgctgc     3240

aataaacata cgtgtgca                                                   3258


<210>  172
<211>  179
<212>  PRT
<213>  homo sapiens

<400>  172

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ala Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  173
<211>  3690
<212>  DNA
<213>  homo sapiens

<400>  173
aatcggtcca attctcggcc gggaagtctc tggccgggac ggggcagggc gaacctgcca       60

gtgactggac tcagcttctt tgcgtaacca atactggaag gcatttaaag gcacctctgc      120

cgccacagac cttgcagtta actccgccct gacccaccct tcccgatgca gtccctgatg      180

caggctcccc tcctgatcgc cctgggcttg cttctcgcgg cccctgcgca agcccacctg      240

aaaaagccat cccagctcag tagcttttcc tgggataact gtgatgaagg gaaggaccct      300

gcggtgatca gaagcctgac tctggagcct gaccccatca tcgttcctgg aaatgtgacc      360

ctcagtgtca tgggcagcac cagtgtcccc ctgagttctc ctctgaaggt ggatttagtt      420

ttggagaagg aggtggctgg cctctggatc aagatcccat gcacagacta cattggcagc      480

tgtacctttg aacacttctg tgatgtgctt gacatgttaa ttcctactgg ggagccctgc      540

ccagagcccc tgcgtaccta tgggcttcct tgccactgtc ccttcaaaga aggaacctac      600

tcactgccca agagcgaatt cgttgtgcct gacctggagc tgcccagttg gctcaccacc      660

gggaactacc gcatagagag cgtcctgagc agcagtggga agcgtctggg ctgcatcaag      720

atcgctgcct ctctaaaggg catataacat ggcatctgcc acagcagaat ggagcggtgt      780

gaggaaggtc ccttttcctc tgttttgtgt ttgccaaggc caaactccca ctctctgccc      840

ccctttaatc ccctttctac agtgagtcca ctaccctcac tgaaaatcat tttgtaccac      900

ttacatttta ggctggggca agcagccctg acctaaggga gaatgagttg gacagttctt      960

gatagcccag ggcatctgct gggctgacca cgttactcat ccccgttaac attctctcta     1020

aagagcctcg ttcatttcca aagcagttaa ggaatgggaa ccagagtgtt ttaggacctg     1080

aagaatcttt atgactctct ctctttcact cttttttttt tttgtcacta agttaaaagc     1140

gaagtgagag tattaacgtt tttgttctcc tccggccccc tgttacaatg aaggggcaaa     1200

agtatttgct cttagtctat tcctccctta acttctgtga ctaattttta tttcctttct     1260

agatttgccc aattaatact agggtgcagt gtatcctgga gaggtagggt gtgtggggga     1320

ggaatccctt gggggagata ttaggagtgc tctgttgttt acaaactcag gtacccgcag     1380

ggcctagcaa gagacttaaa tgactgataa gaaccgtgag aaacatgttg cttccaggct     1440

tgatttcgat ttttcgcttt tttttttttt gagacagaat ctcactttgt caccaggctg     1500

gagtgcagtg gtgcaatctc acctcactgc aacctccgcc tcctgggttc aagcaattct     1560

cctgcctcag cctcccaagt agcttggact acaggccctg ccaccacgcc cggctaattt     1620

gtgtattttt agtagagatg gggtttcacc atgttggcca ggatggtctc gatctcttga     1680

cctcgtgatc tgtccacctt ggccttgcaa agcgctggat tacaggcatg agccactaca     1740

cccagccgat ttttcctttt tgattaaaga tgctattaca atgtaaatat ttcttacaca     1800

gaaagtcaca gcacatgtgc ccattgatac aaggctgctg aggcctggtc tccagttgga     1860

aatataatta agggtggcaa ggactggagt cagttggaga gtgcatagcc agtctgtgaa     1920

gacaactgcc agatactggc aatactccag cctggtgaca gagtgagact ctgtctcaaa     1980

aaaaaagttt caatgtttac tcctagagaa gccaaaaatc cagatttgta tatgaaatct     2040

taccatttta aaagattggc agctaattat ttttttaaaa agctgtgcag tgtgatgtgt     2100

cccaaacgga ctggctcatg ggtggccacg tcacaacctc tgatctcaga ccgtgcatgc     2160

cttgtcctct taagacaact cctgtggcac cgtttctccc tccacagggc caaagccata     2220

gtgtccggtc ccaaggacaa ggctcttcca gtgctaggag aggtatgagc agcctctcac     2280

ctgtgagctg tggggatcac aaggctgcct gcctcagtct tggagtcctg ttgggtgaat     2340

gaggcagatg ggaaagagcc tcaccagcag ctgcttttgg agcaggggtc caaggaagag     2400

agggtggcct cgacatcaaa ctgcctggat ttttctacca ccctgttaca tcataacaac     2460

ttctgaaaca cacaccagcc ctgagttctg ggctcatttg aagcctggaa tagcaataaa     2520

tctttttaac ttgcggacag tttccccttg ccttggctgc atatttcact gatcacatct     2580

caggatttca aaagcatttt tggggtgggg ctcttttggt tggaagggtt tgttggaacg     2640

gtacaggtga gccgaggtga ttccagggac ggacccttct gcaggagctt gagcttgctt     2700

gttgtctctg cttcatcgcc atccagctcc cttgtttgct attttgcttt ccatcacatc     2760

atgactgcgg agagcaaaaa tcacctagtg accattgaac aggtcccaga gacaaaatct     2820

ttttatctga ggaatttaaa agggagcaaa gaccacctgg tgactatcag gccatgcaga     2880

ggcaaaacgc cttatttggg gaaaattaaa agtaattaga ctttcctatt atctaaagca     2940

ggcatctggt tccagatttc ttttccccga aaaaaacctt agaagtaact aaaatttctg     3000

tacatctccg gaatgccatg ctgaaactca ctgcaacccc acggtcccgc tttaaggtcc     3060

ataaatatcc ctaaggaaaa atccaccgtg gtacattcag tcctctcacc gaggtgcccc     3120

atggcagtct tctgcagcat tcttctaata cctttccttt ttcaaaccta tactgttgtt     3180

ggtgaattct ttttaccaac ccacgagttg accacttccc aatgccgggg atctgacacc     3240

tcacctggca atgacctcca cagccgtttc cctctgttgg atcttccagc cttattctca     3300

acagttcatt tttagttcac attcttgacc gaatctcagt agctcagtta atctttttat     3360

gtctgctctg ctcttgggtc atatgttccg tgaggtttct taggggtggg ggatgaggag     3420

ttaaaggtgg catcttcaat cgcaggtcaa agcagacttt aataaatggt gctgagccaa     3480

ctggaaagcc ccttggagaa agttgaagtt agacctgtac ttcacaccat atgcaagaat     3540

gaactccatc tggatccagg atccaaatgt aagaaaatga agccatataa atacagaagg     3600

aaacgtggtg gaaatatcca gtggcaacaa aatattgaca catttgacta catgaagata     3660

ataaaaatgc ttagtaaaaa cacaataaaa                                      3690


<210>  174
<211>  193
<212>  PRT
<213>  homo sapiens

<400>  174

Met Gln Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser 
            20                  25                  30          


Ser Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile 
        35                  40                  45              


Arg Ser Leu Thr Leu Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val 
    50                  55                  60                  


Thr Leu Ser Val Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu 
65                  70                  75                  80  


Lys Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys 
                85                  90                  95      


Ile Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys 
            100                 105                 110         


Asp Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro 
        115                 120                 125             


Leu Arg Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr 
    130                 135                 140                 


Tyr Ser Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro 
145                 150                 155                 160 


Ser Trp Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser 
                165                 170                 175     


Ser Gly Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly 
            180                 185                 190         


Ile 
    


<210>  175
<211>  6041
<212>  DNA
<213>  homo sapiens

<400>  175
caatcccaca gagtattgat gaggaaactg aagtttggag cgatcacatc attttcccaa       60

ggtaacacaa gtggcaagac agccgggaac ccctacccca tccccttatt cagcacatga      120

aataaacaag gggcatccaa atcttgcggc aacgcccccg ggacatgcat cgtcccctgg      180

actctctcaa accccttatc cctctggaca gaatgcaggt ccaaccacgc tggtataccc      240

tcaaacccct cagacaatga attcacaacc tcaaacccgt tctccgtttt tccagaggcc      300

tcaaatacag cctcctagag ctaccatccc gaacagcagt ccttccattc gtcctggtgc      360

acagacaccc actgcagtgt accaggctaa tcagcacatc atgatggtta accatctgcc      420

catgccgtac ccagtgcccc aggggcctca gtactgtata ccacagtacc gtcatagtgg      480

ccctccttat gttgggcccc cccaacaata tccagttcaa ccaccggggc caggtccttt      540

ttatcctgga ccaggacctg gggacttccc caatgcttat ggaacgcctt tttacccaag      600

tcagccggtg tatcagtcag cacctatcat agtgcctacg cagcaacagc cgcctccagc      660

caagagagag aaaaaaacta taagaattcg ggatccaaac cagggaggta aagacataac      720

agaggagatt atgtctggag gtggcagcag aaatcctact ccacccatag gaagacccac      780

gtccacacct actcctcctc agcagctgcc cagccaggtc cccgagcaca gccctgtggt      840

ttatgggact gtggagagcg ctcatcttgc tgccagcacc cctgtcactg cagctagcga      900

ccagaagcaa gaggagaagc caaaaccaga tccagtgtta aagtctcctt ccccagtcct      960

taggctagtc ctcagtggag agaagaaaga acaagaaggc cagacatctg aaactactgc     1020

aatagtatcc atagcagagc ttcctctgcc tccatcacct accactgttt cttctgttgc     1080

tcgaagtaca attgcagccc ccacctcttc tgctcttagt agccaaccaa tattcaccac     1140

tgctatagat gacagatgtg aactctcatc cccaagagaa gacacaattc ctatacccag     1200

cctcacatct tgcacagaaa catcagaccc tttaccaaca aatgaaaatg atgatgatat     1260

atgcaagaaa ccctgtagtg tagcacctaa tgatattcca ctggtttcta gtactaacct     1320

aattaatgaa ataaatggag ttagcgaaaa attatcagcc acggagagca ttgtggaaat     1380

agtaaaacag gaagtattgc cattgactct tgaattggag attctcgaaa atcccccaga     1440

agaaatgaaa ctggagtgta tcccagctcc catcacccct tccacagttc cttcctttcc     1500

tccaactcct ccaactcctc cagcttctcc tcctcacact ccagtcattg ttcctgctgc     1560

tgccactact gttagttctc cgagtgctgc catcacagtc cagagagtcc tagaggagga     1620

cgagagcata agaacttgcc ttagtgaaga tgcaaaagag attcagaaca aaatagaggt     1680

agaagcagat gggcaaacag aagagatttt ggattctcaa aacttaaatt caagaaggag     1740

ccctgtccca gctcaaatag ctataactgt accaaagaca tggaagaaac caaaagatcg     1800

gacccgaacc actgaagaga tgttagaggc agaattggag cttaaagctg aagaggagct     1860

ttccattgac aaagtacttg aatctgaaca agataaaatg agccaggggt ttcatcctga     1920

aagagacccc tctgacctaa aaaaagtgaa agctgtggaa gaaaatggag aagaagctga     1980

gccagtacgt aatggtgctg agagtgtttc tgagggtgaa ggaatagatg ctaattcagg     2040

ctccacagat agttctggtg atggggttac atttccattt aaaccagaat cctggaagcc     2100

tactgatact gaaggtaaga agcagtatga cagggagttt ctgctggact tccagttcat     2160

gcctgcctgt atacaaaaac cagagggcct gcctcctatc agtgatgtgg ttcttgacaa     2220

gatcaaccaa cccaaattgc caatgcgaac tctggatcct cgaattttgc ctcgaggacc     2280

agactttaca ccagcctttg ctgattttgg aaggcagaca cctggtggaa gaggcgtacc     2340

tttgttgaat gttgggtcac gaagatctca acctggccaa agaagagaac ccagaaagat     2400

catcacagtt tctgtaaaag aagatgtaca cctgaaaaag gcagaaaatg cctggaagcc     2460

aagccaaaaa cgagacagcc aagccgatga tcccgaaaac attaaaaccc aggagctttt     2520

tagaaaagtt cgaagtatct taaataaatt gacaccacag atgttcaatc aactgatgaa     2580

gcaagtgtca ggacttactg ttgacacaga ggagcggctg aaaggagtta ttgacctggt     2640

ctttgagaag gctattgatg aacccagttt ctctgtggct tacgcaaaca tgtgtcgatg     2700

tctagtaacg ctgaaagtac ccatggcaga caagcctggt aacacagtga atttccggaa     2760

gctgctactg aaccgttgcc agaaggagtt tgaaaaagat aaagcagatg atgatgtctt     2820

tgagaagaag cagaaagaac ttgaggctgc cagtgctcca gaggagagga caaggcttca     2880

tgatgaactg gaagaagcca aggacaaagc ccggcggaga tccattggca acatcaagtt     2940

tattggagaa ctctttaaac tcaaaatgct gactgaagcc atcatgcatg actgtgtggt     3000

gaagctgcta aagaaccatg atgaagaatc cctggagtgc ctgtgtcgcc tgctcaccac     3060

cattggcaaa gacttggact ttgaaaaagc aaagccacgt atggaccagt actttaatca     3120

gatggagaaa attgtgaaag aaagaaaaac ctcatctagg attcggttca tgcttcaaga     3180

tgttatagac ctaaggctgt gcaattgggt atctcgaaga gcagatcaag ggcctaaaac     3240

tatcgaacag attcacaaag aggctaaaat agaagaacaa gaagagcaaa ggaaggtcca     3300

gcaactcatg accaaagaga agagaagacc aggtgtccag agagtggacg aaggtgggtg     3360

gaacactgta caaggggcca agaacagtcg ggtactggac ccctcaaaat tcctaaaaat     3420

cactaagcct acaattgatg aaaaaattca gctggtacct aaagcacagc taggcagctg     3480

gggaaaaggc agcagtggtg gagcaaaggc aagtgagact gatgccttac ggtcaagtgc     3540

ttccagttta aacagattct ctgccctgca acctccagca ccctcagggt ccacgccatc     3600

cacgcctgta gagtttgatt cccgaaggac cttaactagt cgtggaagta tgggcaggga     3660

gaagaatgac aagccccttc catctgcaac agctcggcca aatactttca tgaggggtgg     3720

cagcagtaaa gacctgctag acaatcagtc tcaagaagag cagcggagag agatgctgga     3780

gaccgtgaag cagctcacag gaggtgtgga tgtggagagg aacagcactg aggctgagcg     3840

aaataaaaca agggagtcag caaaaccaga aatttcagca atgtcagctc atgacaaggc     3900

tgcattatca gaagaggaac tggagaggaa gtcgaaatct atcattgatg aatttctaca     3960

cattaatgat tttaaggaag ccatgcagtg tgtggaagag ctgaatgccc agggcctact     4020

acatgttttt gtgagagtgg gagtggagtc caccctggaa aggagccaga tcaccaggga     4080

tcacatgggc caattactct atcagctggt acagtcagaa aaactcagca aacaggactt     4140

tttcaaaggt ttttcagaaa ctttggaatt ggcagatgac atggccattg atattcccca     4200

tatttggttg taccttgctg aactggtgac ccccatgtta aaagaaggtg gaatctccat     4260

gagagaactt accatagaat ttagcaaacc tttacttcct gttggaagag ctggggtctt     4320

gctatctgaa atattgcacc tactatgcaa acaaatgagc cataagaaag tgggagcctt     4380

atggagggag gctgacctca gctggaagga ctttttacca gaaggagaag atgtacataa     4440

ttttcttttg gagcagaagt tggacttcat agagtctgac agtccctgtt cctctgaagc     4500

actttcaaag aaagaactgt ctgccgaaga gctgtataag cgactcgaga aactcattat     4560

tgaggacaaa gcgaatgatg aacagatctt tgactgggta gaggctaatc tagacgaaat     4620

ccagatgagt tcacctacat tccttagagc tttaatgact gctgtttgta aagcagctat     4680

tatagccgac tcttctacct tcagagtgga cactgctgtt atcaagcaga gagtgccgat     4740

cttactcaag tacctagact cagatacaga gaaggaactg caagcacttt atgcactaca     4800

agcatcgata gtaaaacttg atcaacctgc caatttgctg cggatgtttt ttgattgtct     4860

atatgacgag gaggtgatct ccgaggatgc cttctacaaa tgggagagca gcaaggaccc     4920

tgcagagcag aatgggaagg gcgtggctct gaaatctgtc acggcattct tcacgtggct     4980

gcgggaagca gaagaggagt ctgaggataa ctaaaacttc aaatacacaa aatgaaacaa     5040

aagaaacaat ttaagtattt ttttaaaaag tttcacgtct tcgccaatca cagtgcagca     5100

aggccaattc tcgcagaaac ccccacgtgt gcacgagtgg gagaggggaa agagaaaaaa     5160

aggtgatcat ggaggaaaaa ggtactggat aaaagtaaac ttcaaacctt agggcgggag     5220

cactaaaacc aaaatacatg tattatttat agaaaatatt ttctgtttta atcttttctt     5280

tttaaacaag gactcatact taaaaaaatg tttagcaaaa aaaaaaaaag ttgagaactt     5340

ttaatttatt ttaaggactg caaatgccag tgtaattttt taatttgcag tttctgtaaa     5400

caacttgtat aatagaaaag cagagaaata aatttccctc cccttcaaga tgcacctcat     5460

gtttgtttta aggtatagca tttagtccag atttgagaaa gtttggggtg aacaaggtaa     5520

gaaagatttt tttttttttg gcatcaaatc tttctgcctg cctctcagct tgcttcagaa     5580

aatttaaaaa atcacaatag taatcaaaac atacataaca ttgaaacaga aggaaatgct     5640

gtggaccaca gaactccaag aattgtttaa aaaaaaaaaa gtgctaccct gagaaaagta     5700

ctcttaatac tcttgaaatc tttagagcaa ctttaaggct tgtaaataca tagaacaaat     5760

atttaaaaaa acaaaaagaa attgactcag tactatttct tttcactttg aaaatataaa     5820

gaacaaaata aagacaaaca ttgcaagttt aaaagaaagt aaagtgactt ctcctttgga     5880

cagctgctgc atgtgtgccc attcctgggg gtgctgtctg gctatttatt gtctaattca     5940

aatcactcct gaggggagag agataaaacg agagagagtg agagagtgtg tgtatgtgcg     6000

tgtatgcgca cgtatgtgca tgcacatgta tgtatgtata t                         6041


<210>  176
<211>  1585
<212>  PRT
<213>  homo sapiens

<400>  176

Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro 
    210                 215                 220                 


Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile 
                245                 250                 255     


Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser 
            260                 265                 270         


Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser 
        275                 280                 285             


Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr 
305                 310                 315                 320 


Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys 
                325                 330                 335     


Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser 
            340                 345                 350         


Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala 
        355                 360                 365             


Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr 
    370                 375                 380                 


Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu 
385                 390                 395                 400 


Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro 
                405                 410                 415     


Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val 
            420                 425                 430         


Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val 
        435                 440                 445             


Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln 
465                 470                 475                 480 


Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro 
                485                 490                 495     


Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr Trp Lys Lys Pro 
            500                 505                 510         


Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu Ala Glu Leu Glu 
        515                 520                 525             


Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val Leu Glu Ser Glu 
    530                 535                 540                 


Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg Asp Pro Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu Glu Ala Glu Pro 
                565                 570                 575     


Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu Gly Ile Asp Ala 
            580                 585                 590         


Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val Thr Phe Pro Phe 
        595                 600                 605             


Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly Lys Lys Gln Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro Ala Cys Ile Gln 
625                 630                 635                 640 


Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val Leu Asp Lys Ile 
                645                 650                 655     


Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro Arg Ile Leu Pro 
            660                 665                 670         


Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe Gly Arg Gln Thr 
        675                 680                 685             


Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly Ser Arg Arg Ser 
    690                 695                 700                 


Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile Thr Val Ser Val 
705                 710                 715                 720 


Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala Trp Lys Pro Ser 
                725                 730                 735     


Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn Ile Lys Thr Gln 
            740                 745                 750         


Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys Leu Thr Pro Gln 
        755                 760                 765             


Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu Thr Val Asp Thr 
    770                 775                 780                 


Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe Glu Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met Cys Arg Cys Leu 
                805                 810                 815     


Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly Asn Thr Val Asn 
            820                 825                 830         


Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu Lys Asp 
        835                 840                 845             


Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys Glu Leu Glu Ala 
    850                 855                 860                 


Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn Ile Lys Phe Ile 
                885                 890                 895     


Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met His Asp 
            900                 905                 910         


Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu Glu Cys 
        915                 920                 925             


Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe Glu Lys 
    930                 935                 940                 


Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys Ile Val 
945                 950                 955                 960 


Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln Asp Val 
                965                 970                 975     


Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg Ala Asp Gln Gly 
            980                 985                 990         


Pro Lys Thr Ile Glu Gln Ile His  Lys Glu Ala Lys Ile  Glu Glu Gln 
        995                 1000                 1005             


Glu Glu  Gln Arg Lys Val Gln  Gln Leu Met Thr Lys  Glu Lys Arg 
    1010                 1015                 1020             


Arg Pro  Gly Val Gln Arg Val  Asp Glu Gly Gly Trp  Asn Thr Val 
    1025                 1030                 1035             


Gln Gly  Ala Lys Asn Ser Arg  Val Leu Asp Pro Ser  Lys Phe Leu 
    1040                 1045                 1050             


Lys Ile  Thr Lys Pro Thr Ile  Asp Glu Lys Ile Gln  Leu Val Pro 
    1055                 1060                 1065             


Lys Ala  Gln Leu Gly Ser Trp  Gly Lys Gly Ser Ser  Gly Gly Ala 
    1070                 1075                 1080             


Lys Ala  Ser Glu Thr Asp Ala  Leu Arg Ser Ser Ala  Ser Ser Leu 
    1085                 1090                 1095             


Asn Arg  Phe Ser Ala Leu Gln  Pro Pro Ala Pro Ser  Gly Ser Thr 
    1100                 1105                 1110             


Pro Ser  Thr Pro Val Glu Phe  Asp Ser Arg Arg Thr  Leu Thr Ser 
    1115                 1120                 1125             


Arg Gly  Ser Met Gly Arg Glu  Lys Asn Asp Lys Pro  Leu Pro Ser 
    1130                 1135                 1140             


Ala Thr  Ala Arg Pro Asn Thr  Phe Met Arg Gly Gly  Ser Ser Lys 
    1145                 1150                 1155             


Asp Leu  Leu Asp Asn Gln Ser  Gln Glu Glu Gln Arg  Arg Glu Met 
    1160                 1165                 1170             


Leu Glu  Thr Val Lys Gln Leu  Thr Gly Gly Val Asp  Val Glu Arg 
    1175                 1180                 1185             


Asn Ser  Thr Glu Ala Glu Arg  Asn Lys Thr Arg Glu  Ser Ala Lys 
    1190                 1195                 1200             


Pro Glu  Ile Ser Ala Met Ser  Ala His Asp Lys Ala  Ala Leu Ser 
    1205                 1210                 1215             


Glu Glu  Glu Leu Glu Arg Lys  Ser Lys Ser Ile Ile  Asp Glu Phe 
    1220                 1225                 1230             


Leu His  Ile Asn Asp Phe Lys  Glu Ala Met Gln Cys  Val Glu Glu 
    1235                 1240                 1245             


Leu Asn  Ala Gln Gly Leu Leu  His Val Phe Val Arg  Val Gly Val 
    1250                 1255                 1260             


Glu Ser  Thr Leu Glu Arg Ser  Gln Ile Thr Arg Asp  His Met Gly 
    1265                 1270                 1275             


Gln Leu  Leu Tyr Gln Leu Val  Gln Ser Glu Lys Leu  Ser Lys Gln 
    1280                 1285                 1290             


Asp Phe  Phe Lys Gly Phe Ser  Glu Thr Leu Glu Leu  Ala Asp Asp 
    1295                 1300                 1305             


Met Ala  Ile Asp Ile Pro His  Ile Trp Leu Tyr Leu  Ala Glu Leu 
    1310                 1315                 1320             


Val Thr  Pro Met Leu Lys Glu  Gly Gly Ile Ser Met  Arg Glu Leu 
    1325                 1330                 1335             


Thr Ile  Glu Phe Ser Lys Pro  Leu Leu Pro Val Gly  Arg Ala Gly 
    1340                 1345                 1350             


Val Leu  Leu Ser Glu Ile Leu  His Leu Leu Cys Lys  Gln Met Ser 
    1355                 1360                 1365             


His Lys  Lys Val Gly Ala Leu  Trp Arg Glu Ala Asp  Leu Ser Trp 
    1370                 1375                 1380             


Lys Asp  Phe Leu Pro Glu Gly  Glu Asp Val His Asn  Phe Leu Leu 
    1385                 1390                 1395             


Glu Gln  Lys Leu Asp Phe Ile  Glu Ser Asp Ser Pro  Cys Ser Ser 
    1400                 1405                 1410             


Glu Ala  Leu Ser Lys Lys Glu  Leu Ser Ala Glu Glu  Leu Tyr Lys 
    1415                 1420                 1425             


Arg Leu  Glu Lys Leu Ile Ile  Glu Asp Lys Ala Asn  Asp Glu Gln 
    1430                 1435                 1440             


Ile Phe  Asp Trp Val Glu Ala  Asn Leu Asp Glu Ile  Gln Met Ser 
    1445                 1450                 1455             


Ser Pro  Thr Phe Leu Arg Ala  Leu Met Thr Ala Val  Cys Lys Ala 
    1460                 1465                 1470             


Ala Ile  Ile Ala Asp Ser Ser  Thr Phe Arg Val Asp  Thr Ala Val 
    1475                 1480                 1485             


Ile Lys  Gln Arg Val Pro Ile  Leu Leu Lys Tyr Leu  Asp Ser Asp 
    1490                 1495                 1500             


Thr Glu  Lys Glu Leu Gln Ala  Leu Tyr Ala Leu Gln  Ala Ser Ile 
    1505                 1510                 1515             


Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu Arg Met  Phe Phe Asp 
    1520                 1525                 1530             


Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu Asp Ala  Phe Tyr Lys 
    1535                 1540                 1545             


Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln Asn Gly  Lys Gly Val 
    1550                 1555                 1560             


Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr Trp Leu  Arg Glu Ala 
    1565                 1570                 1575             


Glu Glu  Glu Ser Glu Asp Asn  
    1580                 1585 


<210>  177
<211>  4363
<212>  DNA
<213>  homo sapiens

<400>  177
gcaggctgct ggagaaggcg cacctgctgc aggtgctccc ggccgccccg gaccagcgag       60

cgcgggcact gcggcgggga ggatgctgcg cgagcggacc gtgcggctgc agtacgggag      120

ccgcgtggag gcggtgtacg tgctgggcac ctacctctgg accgatgtct acagcgcggc      180

cccagccggg gcccaaacct tcagcctgaa gcactcggaa cacgtgtggg tggaggtggt      240

gcgtgatggg gaggctgagg aggtggccac caatggcaag cagcgctggc ttctctcgcc      300

cagcaccacc ctgcgggtca ccatgagcca ggcgagcacc gaggccagca gtgacaaggt      360

caccgtcaac tactatgacg aggaagggag cattcccatc gaccaggcgg ggctcttcct      420

cacagccatt gagatctccc tggatgtgga cgcagaccgg gatggtgtgg tggagaagaa      480

caacccaaag aaggcatcct ggacctgggg ccccgagggc cagggggcca tcctgctggt      540

gaactgtgac cgagagacac cctggttgcc caaggaggac tgccgtgatg agaaggtcta      600

cagcaaggaa gatctcaagg acatgtccca gatgatcctg cggaccaaag gccccgaccg      660

cctccccgcc ggatacgaga tagttctgta catttccatg tcagactcag acaaagtggg      720

cgtgttctac gtggagaacc cgttcttcgg ccaacgctat atccacatcc tgggccggcg      780

gaagctctac catgtggtca agtacacggg tggctccgcg gagctgctgt tcttcgtgga      840

aggcctctgt ttccccgacg agggcttctc aggcctggtc tccatccatg tcagcctgct      900

ggagtacatg gcccaggaca ttcccctgac tcccatcttc acggacaccg tgatattccg      960

gattgctccg tggatcatga cccccaacat cctgcctccc gtgtcggtgt ttgtgtgctg     1020

catgaaggat aattacctgt tcctgaaaga ggtgaagaac cttgtggaga aaaccaactg     1080

tgagctgaag gtctgcttcc agtacctaaa ccgaggcgat cgctggatcc aggatgaaat     1140

tgagtttggc tacatcgagg ccccccataa aggcttcccc gtggtgctgg actctccccg     1200

agatggaaac ctaaaggact tccctgtgaa ggagctcctg ggcccagatt ttggctacgt     1260

gacccgggag cccctctttg agtctgtcac cagccttgac tcatttggaa acctggaggt     1320

cagtccccca gtgaccgtga acggcaagac atacccgctt ggccgcatcc tcatcgggag     1380

cagctttcct ctgtctggtg gtcggaggat gaccaaggtg gtgcgtgact tcctgaaggc     1440

ccagcaggtg caggcgcccg tggagctcta ctcagactgg ctgactgtgg gccacgtgga     1500

tgagttcatg tcctttgtcc ccatccccgg cacaaagaaa ttcctgctac tcatggccag     1560

cacctcggcc tgctacaagc tcttccgaga gaagcagaag gacggccatg gagaggccat     1620

catgttcaaa ggcttgggtg ggatgagcag caagcgaatc accatcaaca agattctgtc     1680

caacgagagc cttgtgcagg agaacctgta cttccagcgc tgcctagact ggaaccgtga     1740

catcctcaag aaggagctgg gactgacaga gcaggacatc attgacctgc ccgctctgtt     1800

caagatggac gaggaccacc gtgccagagc cttcttccca aacatggtga acatgatcgt     1860

gctggacaag gacctgggca tccccaagcc attcgggcca caggttgagg aggaatgctg     1920

cctggagatg cacgtgcgtg gcctcctgga gcccctgggc ctcgaatgca ccttcatcga     1980

cgacatttct gcctaccaca aatttctggg ggaagtccac tgtggcacca acgtccgcag     2040

gaagcccttc accttcaagt ggtggcacat ggtgccctga cctgccaggg gccctggcgt     2100

ttgcctcctt cgcttagttc tccagaccct ccctcacacg cccagagcct tctgctgaca     2160

tggactggac agccccgctg ggagaccttt gggacgtggg gtggaatttg gggtatctgt     2220

gccttgccct ccctgagagg ggcctcagtg tcctctgaag ccatccccag tgagcctcga     2280

ctctgtccct gctgaaaata gctgggccag tgtctctgta gccctgacat aaggaacaga     2340

acacaacaaa acacagcaaa ccatgtgccc aaactgctcc ccaaagaatt ttgagtctct     2400

aatctgacac tgaatgaggg gagaagggaa ggagattctg ggattgccag ttcttccagc     2460

agccatgctc tgaaaatcaa ggtagaatcc atggaaaggg accccaggac cccgggaccc     2520

tagacgtatc ttgaactgcc atcgtcattt caaatacatc tccctcaggg tttccaggtg     2580

gccaccccca attattcatt ccttaccaac ctctcaaatc ctcttggctt tctctctgca     2640

gtgtggacac tgttggctag tcctccccac tccctgaggg tccagtaagt tagcttagaa     2700

ccttcctgga aacatttcat ctgagcaggt ttccccacgt gtgggatgct ccttttgcct     2760

catctgtctc agggatgcag gctcccccgc atgcatgggg atttctcccc agaccagcat     2820

acttgtgacc tgagagttca atgcgtaaag atgcccctgg tcagccatat ccatcttctc     2880

ttgcctggtc cttgattctc tggccgctcc ctgaccttcc tccttccact gccttgactt     2940

tcttcctttt tattcctggt gccatctgtc caggcagcta gacaagaact tgttcgccag     3000

cagccagatt caggccttcc caggggcata ataagtgacc agcccctcct ctccggacat     3060

cagatccaac acataaggac cctggcctac cctccagccc aacagccagt tctgggtcag     3120

ctgccaactt aggggtggtt tgattatccc attgaaattc accagtgcct ttgccaaaga     3180

ccctctcatt tggacatacc cagattcatt ccctggctcc aactgaaaag actcagtttc     3240

aatcgttaaa agttccttta gggccagaag aataaatgaa ttataatccc attttgaaga     3300

accgatttat aaccaatgaa aaggttataa tgtaatttat attcttggag gaacaagatt     3360

ttcatttggg attatttcct tcaaccattc aacaaacatt tgttgtatgc cactaagcgc     3420

caggcacggc gttgggctct gcaaacacag tggttagtag cagtctggac ctggtcccta     3480

ctggcatgga acccatcact ccccaacatg caaagcccac atttaaaggc cagcctctgc     3540

cccttcagtg atgcgctctt tagaaatgcc agtccactat attcagaaat ccgcagggca     3600

caaaacttcc agcaagtcac tgttgtggtg aaatgggcag tgggggtggg gggtcttctt     3660

taaacaggcc cccttcccat ctacctagcc agtacccatc caatgagtcc ccagagcctc     3720

cagaagctgt tgtctcctct ctggggacag cagctcctgc ctttggaggc caaagcccca     3780

gatctctcca gccccagagc tgaaaacacc aagtgcctat ttgagggtgt ctgtctggag     3840

acttagagtt tgtcatgtgt gtgtgtgtgt ttggttaatg tgggtttatg ggttttcttt     3900

cttttttttc tttttttttt tagtctacat tagggggaag tgagcgcctc ccatgtgcag     3960

acagtgtgtc tttatagatt tttctaaggc tttccccaat gatgtcggta atttctgatg     4020

tttctgaagt tcccaggact cacacacccg ttcccatctc acttgcccac ccagtgtgac     4080

aaccctcggt gtggatatac ccccgtggac tcatggctct tccccacccc cactttctat     4140

aaatgtaggc ctagaatacg cttctctgtt gcaaaactca gctaagttcc tgcttccacc     4200

ttgatgttga aatatcttat gtaagagggc aggggatgtc gtgaagatgg caagaagaac     4260

acagtttcaa atttctggaa aagagcctgt ggtggagatc taaagatgtt tagggaagag     4320

ctcgactaaa gaacaatgaa ataaatggtc caaggggaag tca                       4363


<210>  178
<211>  665
<212>  PRT
<213>  homo sapiens

<400>  178

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  179
<211>  2900
<212>  DNA
<213>  homo sapiens

<400>  179
ctcgtccgct cgcgctgccc accgcggctc cagcagctcc aggcgcggtt ccccggcccg       60

cgccgctccc ggccccccgg ctcgggcgcc tcccgccgca gcgcaggctc ccccgccggc      120

cgggctcctg cgcggcgcgg ctcggctcat gcccccgggc gcggggcaca caggccggcc      180

ggcagccgct gggaaatagg cccccggggg cggtggcggc ggcggggcca tggcgcggag      240

accccgggcg ccggccgcct ccggggagga gttctccttc gtcagcccgc tggtgaaata      300

cctgctcttc ttcttcaaca tgctcttctg ggtgatttcc atggtgatgg tggctgtggg      360

tgtctacgct cggctaatga agcatgcaga agcagcccta gcctgcctgg cagtggaccc      420

tgccatcctg ctgatcgtgg tgggtgtcct catgttcctg ctcaccttct gtggctgcat      480

tgggtccctc cgcgagaaca tctgcctcct gcagacgttc tccctctgcc tcaccgctgt      540

gttcctgctg cagctggccg ctgggatcct gggcttcgtc ttctcagaca aggctcgagg      600

gaaagtgagt gagatcatca acaatgccat tgtgcactac cgagatgact tggatctgca      660

gaacctcatt gattttggcc agaaaaagtt tagctgctgt ggagggattt cctacaagga      720

ctggtctcag aacatgtatt tcaactgctc agaagacaac cccagtcgag agcgctgctc      780

tgtgccttac tcctgttgct tgcctactcc tgaccaggca gtgatcaaca ctatgtgtgg      840

ccaaggtatg caggcctttg actacttgga agctagcaaa gtcatctaca ccaatggctg      900

tattgacaag ttggtcaact ggatacacag caacctattc ttacttggtg gtgtggctct      960

aggcctggcc atcccccagc tggtgggaat tctgctgtcc cagatcctag tgaatcagat     1020

caaagatcag atcaagctac agctctacaa ccagcagcac cgggctgacc catggtactg     1080

agaatccatc ctgcacctcc tcaccatgga aactggcaag cctcataaac gaacagcagt     1140

gggtgctgaa agcagcacca aatggagatt tggattccag ccccccagtg acagcccagt     1200

gggaagaagc aaactccaga tgggcagaag gcagggtgca caggtggctc cagtctcagg     1260

aggatgcgcc tcctctcccc catcccagcc ctcagcattg tgccagagtg atacccttaa     1320

gtgtttgggt ttatgttttc agttttgttt gggaaacagc agttgcacag agagttgggg     1380

gtactgctgc tgccttttca ccgaggcact gccaccacca gctctagcag ggatgctcct     1440

gagcttggcg gacatactta gatcctaacg tgccagtgag acctggctgt ggagagtagc     1500

actggcagcc ctgcctggac tccacttggc atgataccag ctccagaagg gaagggagtg     1560

gagcaggcag tgaggagaga gcctgggggt cggctgggga cagccgtatg tgctaggtag     1620

gagtggaggg agatatgttt accaaatgcc tgtcctgcca tcctcccagg tagtcagagt     1680

gagctacatc ctgccccgcc ttcatttcca tggaaacatg gcagctagga cacggggtac     1740

aacagcagcc aaattcttcc ccacctccct tacttcgaaa aaaagtttgg aaccctggtc     1800

cctatactct gcagtcagaa gtgggactga gccatacatg cccttgaatt cctccctgtc     1860

tggccctccc tctccagcaa gcagggtttt ctttaacttg gcagtgtgca gaggagaagt     1920

ggtaacaccc ccaccccatt cccctgcatc ggagctcagt attcctacag ggtaagaggt     1980

aggaatcttg ctgggacgag gggagccaga agtggcaata aaagcgtgtt gacctgggct     2040

acgcgggact ccatgaattt tccattctgg caactggaag gggaggtgta gaagggccct     2100

gcagaggacg gcactggaga ctctcctaaa cgccacacac ctcccccttg ctgcccgcca     2160

cacgcgcgtc tccttcaacc gatgcattgc caccctccca cagcctcgcc ctctgctcta     2220

aattaggtcg aaagagtccc agttccaatc taggaacagc ataattttgt tccaaaacct     2280

gatctgtgtt tttctaatta aaattaattt gtcacccaaa acaggagggg gatggggagg     2340

agggacatga gcactccgct ggggccggga cggggaatga ggaggaagaa ggccctctct     2400

tcccctaccc gggccctcca ggaccttctc cctgagtcgg ctgtagggag gactccgagg     2460

aagctcggcg cggtgcgctg ggcctcctgg cgccgggagg agcgcgcgag gcaggcgggg     2520

cgggcgcgtc cggggcgggg cgctggactt cgtgggtggt ccccgccccc gcggcggcct     2580

aggcccgcgc ctgcgtcccc caacccggag gagatggggg gctgtgctag ctgcttgccc     2640

agcgagtgtt cccggagtct cctcgccgca ccccgctatc gggcgctcag accaggggct     2700

cggcctggcg ggaaatagcc tcgaccgaac tgctgcgggg acaaagagcc gcgagttcgc     2760

tccctgcccc cagtgtctcc taagcgagcc ttctgctcct aggaaggcgc ctttccagca     2820

gccgctggga ccctggccag tgtttagctc ccaactagta acagacggaa agaaaaaata     2880

aaattatcca gaatctagaa                                                 2900


<210>  180
<211>  283
<212>  PRT
<213>  homo sapiens

<400>  180

Met Ala Arg Arg Pro Arg Ala Pro Ala Ala Ser Gly Glu Glu Phe Ser 
1               5                   10                  15      


Phe Val Ser Pro Leu Val Lys Tyr Leu Leu Phe Phe Phe Asn Met Leu 
            20                  25                  30          


Phe Trp Val Ile Ser Met Val Met Val Ala Val Gly Val Tyr Ala Arg 
        35                  40                  45              


Leu Met Lys His Ala Glu Ala Ala Leu Ala Cys Leu Ala Val Asp Pro 
    50                  55                  60                  


Ala Ile Leu Leu Ile Val Val Gly Val Leu Met Phe Leu Leu Thr Phe 
65                  70                  75                  80  


Cys Gly Cys Ile Gly Ser Leu Arg Glu Asn Ile Cys Leu Leu Gln Thr 
                85                  90                  95      


Phe Ser Leu Cys Leu Thr Ala Val Phe Leu Leu Gln Leu Ala Ala Gly 
            100                 105                 110         


Ile Leu Gly Phe Val Phe Ser Asp Lys Ala Arg Gly Lys Val Ser Glu 
        115                 120                 125             


Ile Ile Asn Asn Ala Ile Val His Tyr Arg Asp Asp Leu Asp Leu Gln 
    130                 135                 140                 


Asn Leu Ile Asp Phe Gly Gln Lys Lys Phe Ser Cys Cys Gly Gly Ile 
145                 150                 155                 160 


Ser Tyr Lys Asp Trp Ser Gln Asn Met Tyr Phe Asn Cys Ser Glu Asp 
                165                 170                 175     


Asn Pro Ser Arg Glu Arg Cys Ser Val Pro Tyr Ser Cys Cys Leu Pro 
            180                 185                 190         


Thr Pro Asp Gln Ala Val Ile Asn Thr Met Cys Gly Gln Gly Met Gln 
        195                 200                 205             


Ala Phe Asp Tyr Leu Glu Ala Ser Lys Val Ile Tyr Thr Asn Gly Cys 
    210                 215                 220                 


Ile Asp Lys Leu Val Asn Trp Ile His Ser Asn Leu Phe Leu Leu Gly 
225                 230                 235                 240 


Gly Val Ala Leu Gly Leu Ala Ile Pro Gln Leu Val Gly Ile Leu Leu 
                245                 250                 255     


Ser Gln Ile Leu Val Asn Gln Ile Lys Asp Gln Ile Lys Leu Gln Leu 
            260                 265                 270         


Tyr Asn Gln Gln His Arg Ala Asp Pro Trp Tyr 
        275                 280             


<210>  181
<211>  5121
<212>  DNA
<213>  homo sapiens

<400>  181
acaaaggcgc ccgcccgccg cccgccgccc gcgcccgcgc cgccgccatg aagccggggc       60

cgccgcaccg tgccggggcc gcccacgggg ccggcgccgg ggccggggcc gcggccgggc      120

ccggggcccg cgggctgctc ctgccaccgc tgctgctgct gctgctggcg gggcgcgccg      180

cgggggccca gcgctggcgc agtgagaact tcgagagacc cgtggacctg gagggctctg      240

gggatgatga ctcctttccc gatgatgaac tggatgacct ctactcgggg tcgggctcgg      300

gctacttcga gcaggagtcg ggcattgaga cagccatgcg cttcagccca gatgtagccc      360

tggcggtgtc caccacacct gcggtgctgc ccaccacgaa catccagcct gtgggcacac      420

catttgaaga gctcccctct gagcgcccca ccctggagcc agccaccagc cccctggtgg      480

tgacagaagt cccggaagag cccagccaga gagccaccac cgtctccact accatggcta      540

ccactgctgc cacaagcaca ggggacccga ctgtggccac agtgcctgcc acagtggcca      600

ccgccacccc cagcacccct gcagcacccc cttttacggc caccactgct gttataagga      660

ccactggcgt acggaggctt ctgcctctcc cactgaccac agtggctacg gcacgggcca      720

ctacccccga ggcgccctcc ccgcccacca cggcggctgt cttggacacc gaggccccaa      780

cacccaggct ggtcagcaca gctacctccc ggccaagagc ccttcccagg ccggccacca      840

cccaggagcc tgacatccct gagaggagca ccctgcccct ggggaccact gcccctggac      900

ccacagaggt ggctcagacc ccaactccag agaccttcct gaccacaatc cgggatgagc      960

cagaggttcc ggtgagtggg gggcccagtg gagacttcga gctgccagaa gaagagacca     1020

cacaaccaga cacagccaat gaggtggtag ctgtgggagg ggctgcggcc aaggcatcat     1080

ctccacctgg gacactgccc aagggtgccc gcccgggccc tggcctcctg gacaatgcca     1140

tcgactcggg cagctcagct gctcagctgc ctcagaagag tatcctggag cggaaggagg     1200

tgctcgtagc tgtgattgtg ggcggggtgg tgggcgccct ctttgctgcc ttcttggtca     1260

cactgctcat ctatcgtatg aagaaaaagg atgagggcag ctacacgctg gaggaaccca     1320

agcaggcgag cgtcacatac cagaagcctg acaagcagga ggagttctat gcctagtgga     1380

gccacagtgc ctccctgcag cctcaacacc accctgctgt ccagtcccca gcctggcccc     1440

accagcccaa gcctgggact gggcctggaa cctggcccca gttcttctct gccctctctc     1500

ccaaggtctg cccaggctgc cagcctcaca cagatcttcc ccgaggaaga ggggctgctg     1560

ccatctgccc cagactgtgc ccttacgagc tcatctcttg ttcccctcat ccctgccacc     1620

agtctggggc ttcaggacct catgtcagat ggatgggagg aagaaagctc ctgattggct     1680

ggtggtggaa gaaagggtgg ggcttgagat gagcctgagc cctgacttgg cacccacagt     1740

gctcactgag atctcctttt tggggcagag aggcactcag gctggtttcc aggacaaaca     1800

tttggtaaac acagcccttg aaatcatcta gacactgcaa cctcttgctc gtatcccagg     1860

gcctctctct agctgggtga gagggtgtcc cttgtcacca gcctgttttg tcctggtctc     1920

tctggggttg ttgaatctct cctcttgcct gccaagtaca catgtaccca gacttcattt     1980

ctttctgcat cttcccccaa gaaacagctt cctgagggtg ctggggcagc cactggtgag     2040

gaggggctgc tctgatgtcc ctcctatgag gggactctgc acagacacca ttgcccacac     2100

tatcaccata ttttcactca gtcacacaca agacaaaagc atgcaatgac aaaaccatac     2160

gcaatcctga ccgcccagcc aatcaagaca tatcacagaa cacacgcgtc cttccaagaa     2220

tgtttatcct catgcatcac ttacacaccc ccagacacgt actgcaatgc aagtcactag     2280

tcatggtcac atgacagtga cagtgtggcc tcctcctacc ccaaatacac ccacactctg     2340

gcaccacaca cattgtctcc agctttcagg cttactgggg agggtggaat cgagccagaa     2400

caatcagccc atattgggtc cccctaagtt gccccgtcat actcagtccc atgccatggt     2460

gcccacacca accatgcagc cgccaacccc agccagtgtc agacacaatc ccatgtggat     2520

gcacagtctc actccacatg acctgctctc aatgctggag ggaaacaggc aggcccttgc     2580

ctttctcgga aaaagtgtgg ggccacagcc cttttagggc attgcatgca ggtgggcctg     2640

gcttcacccc tacctgcttc ctccccaccg cagctggcag agggggaggt ttggggccag     2700

acccccacta gctgggagcc tgggggctcc tctaaggctg aggaaggaaa tttggcccca     2760

ggttgttggg gggtcttggg tctcccagga cggaaggccc agggcaggga gggggcatgt     2820

ggttgggctc ctttatctcc ctgtgtcccc ttcctgcttt gagctagggg gctgactctg     2880

cctcccagga cacaagtctc caaagtgcct gtgagggcgg gccctccgca ccctctgccc     2940

tctgcctggc aggccaacct cagcccacct gcccagaggc cctccctgtg gacaccccct     3000

cacctatttg gccaaacaat tctggctgca gcttcagggg ccatggctgg aagcagcccc     3060

tgcagatccc tcaggccccg aggtcagggt ttgagggatg agaccaggtg atagtggggg     3120

aggggttact tcctttgtta cctagcaagt agggctattt ccatcggtat tttaaatgtg     3180

gggtcacaga tcttttgggg agggtgtgct tggcaggggg cctcttggag ccaaagggat     3240

gtggtgtgag ttgcgattgg ctggcactca cacccccacc cctcacccac atcccagatt     3300

caagtcagga aggcaggttt tatttcaggg cccttttcaa gatgccctgg cagcagattt     3360

ctgcaggatg aggggtagcg gtgtgtaggc agtgaggggg aggttccagg ggctgtccca     3420

cagcctgtct tttccaggct gggctccatc ttccagtccc aaaaccctcc ttcacagggc     3480

ccagaggctt gtgaggaagc caggtggacc cagccttaga agagtgggca tggggggccc     3540

ctgatatctg gagggggcgg gttggcctca gtcatctttg gagcagaagg gctgggtcct     3600

ggggccacag accacaaggc tcagcctccc taccctgctc cctggggtgc tgctgtcttg     3660

gagagcacag ctctggtgag acggcctggg caggccgagg ctgagaaacc agggaggata     3720

gaggagaaaa gggcttgggc ccccagcccc agaagatgct ggaccccagg tgggagaccc     3780

aacagtgggt gcagtttctc agtagggctg gagccaatgg tgggggtggc cccggcaggc     3840

ctggctcctc acatcccagg ggttggcttc tgatttgggg cttgggctcc aggcactggc     3900

ttctcttctc tgtgtcctta gcatttgaga gaagaggcca ggggccttgt tcatggatcc     3960

ctggacccaa ggcagatgtc caggctttat cctcctgagg atgaggagtc tgaccagccc     4020

aaatctgccc tggccggcct gaccggggca aggcagtcca agagagttca gtgaggacca     4080

gctaggctct cccaggtgca atgtgggtgc agggccctca tgtcccccta cccctgcctg     4140

tgatggagtg ttctgagggg ctttggcatt tgctggaagc acagggagtt ccaaatgaga     4200

gggagcttct gtggcttgag agcctctggg gccttggctg ccagagcacg aggcaggcca     4260

ggacctggag agcccagacc ctgtctccag gaggccagga ggccagatgg gggccttgcc     4320

tgaaagactg gtccccttga tcgctggagg catgtgggtg gcaaccaggg ctgggcaggg     4380

cttagggtgt gtgggccaaa cccccctggg gttggcaaag ccgcctgtca ggcctcctgg     4440

tgggggcccc tggacacagg gagcagaccc tctgcctcat ggggtaggag tggctgcctc     4500

ctgtgttctc tggatttctt ctcccaacaa ctacaaccct ggacttgcct ccccaggcct     4560

cttgcctgta aatagaagcc cgcaaactgt acagatttac agaggcatcg agactgggcc     4620

ctgggagttg ccatctgaga gccgatggcc ccagcatccc ccaggtgcct gcctggcacc     4680

acagtgaccc tggcctcagc gtggcaaatg catgtaaata tttttcgtag gcagcgtggc     4740

tccagagagc cccctgaaga cagtgtccct ccctcctgtg agtcctttct cctgtacaga     4800

acctgcctgg ggtgggtggg ggtctgccat tccctccccc aggccttccc tgccccttct     4860

ctcccctgta acctgtttat taaccatacc tgtcctgagt tcatggccaa aaccttaaat     4920

aagaaaaaca aaagaaaaag acagtggaaa aaagagacca aggcgcctgc cccactgcgg     4980

gtactctcct gttccagcct tgtgaaggaa ctggttttgt ttttgttttt tttttttttt     5040

tttttttttt gtttgtttgt ttttttaaca cttcctgtgc tgtgcccatt tataagagga     5100

aataaaatta agctgaaatg a                                               5121


<210>  182
<211>  442
<212>  PRT
<213>  homo sapiens

<400>  182

Met Lys Pro Gly Pro Pro His Arg Ala Gly Ala Ala His Gly Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ala Ala Ala Gly Pro Gly Ala Arg Gly Leu Leu Leu 
            20                  25                  30          


Pro Pro Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln 
        35                  40                  45              


Arg Trp Arg Ser Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser 
    50                  55                  60                  


Gly Asp Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Ile Glu Thr Ala 
                85                  90                  95      


Met Arg Phe Ser Pro Asp Val Ala Leu Ala Val Ser Thr Thr Pro Ala 
            100                 105                 110         


Val Leu Pro Thr Thr Asn Ile Gln Pro Val Gly Thr Pro Phe Glu Glu 
        115                 120                 125             


Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro Ala Thr Ser Pro Leu Val 
    130                 135                 140                 


Val Thr Glu Val Pro Glu Glu Pro Ser Gln Arg Ala Thr Thr Val Ser 
145                 150                 155                 160 


Thr Thr Met Ala Thr Thr Ala Ala Thr Ser Thr Gly Asp Pro Thr Val 
                165                 170                 175     


Ala Thr Val Pro Ala Thr Val Ala Thr Ala Thr Pro Ser Thr Pro Ala 
            180                 185                 190         


Ala Pro Pro Phe Thr Ala Thr Thr Ala Val Ile Arg Thr Thr Gly Val 
        195                 200                 205             


Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr Val Ala Thr Ala Arg Ala 
    210                 215                 220                 


Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr Thr Ala Ala Val Leu Asp 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Pro Arg Leu Val Ser Thr Ala Thr Ser Arg Pro 
                245                 250                 255     


Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln Glu Pro Asp Ile Pro Glu 
            260                 265                 270         


Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu Val 
        275                 280                 285             


Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu Thr Thr Ile Arg Asp Glu 
    290                 295                 300                 


Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu Pro 
305                 310                 315                 320 


Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val 
                325                 330                 335     


Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro Pro Gly Thr Leu Pro Lys 
            340                 345                 350         


Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp Asn Ala Ile Asp Ser Gly 
        355                 360                 365             


Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu 
    370                 375                 380                 


Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala 
385                 390                 395                 400 


Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu 
                405                 410                 415     


Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln 
            420                 425                 430         


Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
        435                 440         


<210>  183
<211>  3887
<212>  DNA
<213>  homo sapiens

<400>  183
gagagcgccg gctgcaaagc gagcgcgagt gtcgacgcgt gcggcgcact aaattgtgcc       60

gcgctcgccc ccgccagacc atgtcctcct ggggaaaaag tttccctagt ccccccagca      120

gcgcgcccca ccctacgccc cgctggaaaa aaaacagcaa cataaaatcc taggcttgaa      180

cattctgtgc gtcccaaatt tctaatgtcc tcggcctgcc cggtttgccg aagggagccg      240

agtgtcgaag agaagtcggg aaaaggtaag ttgtgcagac acttggggaa gtttcaagga      300

gaccgccagc tcaagatgga aaccgcggcc cgggcgctaa ggacgggctt cagctcccgc      360

tggcaaaaag agaaagtcga gcccgccttc ctgcccaaca aaaaacaaca acatgacaac      420

aagaaccccg gagggagtgg aatgagtgac gtcacagccg cgctctgagg ctgacaaagg      480

agggggcgcg cccctcccgc tctgcgcccg cgcggccccg gagagggggc gcctgaagcg      540

ccgggtaggg aagtcagccg acttgaaact tttcctctta aagaaaaaaa aaaaaaagtt      600

gtgcgcggct cacagtgggg tttttttttt ccgccttctt ttctcgtctc ccctccccct      660

tcttcctttt gaaagtttct tctcctcccc ctgccccccc tccccgcctg accgcatggc      720

tgattcaact ccagtgtcaa tcaacttctt tttcctcctc ttcctcattt aaataagttt      780

aaagctcctc ctccccccgg cccaccaaat ctgaacttta taaattgggc tttgcgcgcc      840

ccagcccgga gtcagaaagg cgaggggcgc cgggaactgg cgtgtgggac tccagacagg      900

agaggctgcg ccttccccgc accgggacct tcgcgacaca ccagatcctc gcccctggct      960

cgcgcgaacg cacaggatga ccaccaccct cgtgtctgcc accatcttcg acttgagcga     1020

agttttatgc aagggtaaca agatgctcaa ctatagtgct cccagtgcag ggggttgcct     1080

gctggacaga aaggcagtgg gcacccctgc tggtgggggc ttccctcgga ggcactcagt     1140

caccctgccc agctccaagt tccaccagaa ccagctcctc agcagcctca agggtgagcc     1200

agcccccgct ctgagctcgc gagacagccg cttccgagac cgctccttct cggaaggggg     1260

cgagcggctg ctgcccaccc agaagcagcc cgggggcggc caggtcaact ccagccgcta     1320

caagacggag ctgtgccgcc cctttgagga aaacggtgcc tgtaagtacg gggacaagtg     1380

ccagttcgca cacggcatcc acgagctccg cagcctgacc cgccacccca agtacaagac     1440

ggagctgtgc cgcaccttcc acaccatcgg cttttgcccc tacgggcccc gctgccactt     1500

catccacaac gctgaagagc gccgtgccct ggccggggcc cgggacctct ccgctgaccg     1560

tccccgcctc cagcatagct ttagctttgc tgggtttccc agtgccgctg ccaccgccgc     1620

tgccaccggg ctgctggaca gccccacgtc catcacccca ccccctattc tgagcgccga     1680

tgacctcctg ggctcaccta ccctgcccga tggcaccaat aacccttttg ccttctccag     1740

ccaggagctg gcaagcctct ttgcccctag catggggctg cccgggggtg gctccccgac     1800

caccttcctc ttccggccca tgtccgagtc ccctcacatg tttgactctc cccccagccc     1860

tcaggattct ctctcggacc aggagggcta cctgagcagc tccagcagca gccacagtgg     1920

ctcagactcc ccgaccttgg acaactcaag acgcctgccc atcttcagca gactttccat     1980

ctcagatgac taagccaggg tagggaggga cctcctgcct actccagccc ctaccctgca     2040

cccacatccc ataccctctt ctccctaccc atcccattcc ccacaggccc tacattaaca     2100

aggttaagct caaccccttt cccccagcac ctcagaatgt gccctccctc tccccctcat     2160

aaccccacct aacataagga caagtcaatt tgtcagtagc ttcttctggc ttgaaacccc     2220

ctccctggat tttatagccc acttaccatg cataacagac aagtcccata ttttgtcagt     2280

agatgccttt ttttttccgg cttaagcctt aagtgccaaa tcacaagaga aaaagcagta     2340

acagtttaca gaagcaactt agtgccttgt aatctaactt tgtcactgtg actacattac     2400

ctcttcagcg ccagagggca cccgtgggcc tcccggagcc tctgcccatg gcggggtgga     2460

gacccggaac cagcagcccc ctccactggc gacacaactg caccttccct catttcagtc     2520

tcccgcacac ttattcctcc tcccctcttc ccggtggcac ctctccacct gtacccgccc     2580

ccccaccccc cccacccctg ccccttggaa gagttgttgc cagaccaggg ttttggggga     2640

aacctgtctt gacattcaaa acctttttct tcccgatctg aacccctgtt gactaatctt     2700

gcctgggttt gtgtaggtct gcaggaagga aggctgaaaa agcggacgaa gattttgact     2760

taagtgggac tttgtgattt aattttttct tttttttaag tggggaggaa ggggaagcta     2820

gatggactag gagagacttg attttggtgc taaagttccc cagttcatat gtgacatctt     2880

tttaaaaaaa ataacaacaa aaaaaaaatg agagaaaagc taaaaaaaaa aaagtaaggg     2940

gtgagcagtt aatggtattc attccacata caatatctgt gtaaaacgat ttcctgtaga     3000

agtagcttta atggtttttg ctctagaata ccgtaggtct atccttagag cactcacgcc     3060

atgctttctt ccctgggttt taaacttcat ataactttca gaaattggag agcaaaaatt     3120

ttgcttgtca ctgcacatca atataaaaaa gcttatttaa cttatcaaaa cgtatttatt     3180

gccaaactat gctttttttt gttaattttg ttcatattta tcgggatgac aaatccatag     3240

aatatattct tttatgttaa attatgatct tcatattaat cttaaaattt tgtgacgtgt     3300

ctttttcctt tttttccaca gttttaatat attattcttc aacgacattt tttgtaactt     3360

tacacttttt tggttatttt attttaaaaa aatgaaaaat taatttaaaa aaatgcaaaa     3420

aactgttgga ttatttattt tagaaattcc cccctttgtg ttggactgca aattgagttt     3480

ctttctcttt aggcctttca caactaggac tgagaatgta tgtaaaagtt ctgtgacagt     3540

acagaaggaa aacaactttt tatgtatagc ttctaaaagg ggaaaaaaaa aaaaagagaa     3600

accctttgac ttccacgtgc ccatctcaag acattccact cacagatttg aggttctgga     3660

ttccaggtct ggagttttcc aatgttaatg taaacagaac tggcacacac acattaagat     3720

gaatgtaatt attattcctc ttgctggtca ctaccgtcgc tttctatttc tctttctttg     3780

tgtgaattta tttaaaagaa aaaaaaactt tttgtaacga ctatttgcag tttaaaaatc     3840

aataaacccc gttttttcaa gaaacattga taaaaaaaaa aaaaaaa                   3887


<210>  184
<211>  338
<212>  PRT
<213>  homo sapiens

<400>  184

Met Thr Thr Thr Leu Val Ser Ala Thr Ile Phe Asp Leu Ser Glu Val 
1               5                   10                  15      


Leu Cys Lys Gly Asn Lys Met Leu Asn Tyr Ser Ala Pro Ser Ala Gly 
            20                  25                  30          


Gly Cys Leu Leu Asp Arg Lys Ala Val Gly Thr Pro Ala Gly Gly Gly 
        35                  40                  45              


Phe Pro Arg Arg His Ser Val Thr Leu Pro Ser Ser Lys Phe His Gln 
    50                  55                  60                  


Asn Gln Leu Leu Ser Ser Leu Lys Gly Glu Pro Ala Pro Ala Leu Ser 
65                  70                  75                  80  


Ser Arg Asp Ser Arg Phe Arg Asp Arg Ser Phe Ser Glu Gly Gly Glu 
                85                  90                  95      


Arg Leu Leu Pro Thr Gln Lys Gln Pro Gly Gly Gly Gln Val Asn Ser 
            100                 105                 110         


Ser Arg Tyr Lys Thr Glu Leu Cys Arg Pro Phe Glu Glu Asn Gly Ala 
        115                 120                 125             


Cys Lys Tyr Gly Asp Lys Cys Gln Phe Ala His Gly Ile His Glu Leu 
    130                 135                 140                 


Arg Ser Leu Thr Arg His Pro Lys Tyr Lys Thr Glu Leu Cys Arg Thr 
145                 150                 155                 160 


Phe His Thr Ile Gly Phe Cys Pro Tyr Gly Pro Arg Cys His Phe Ile 
                165                 170                 175     


His Asn Ala Glu Glu Arg Arg Ala Leu Ala Gly Ala Arg Asp Leu Ser 
            180                 185                 190         


Ala Asp Arg Pro Arg Leu Gln His Ser Phe Ser Phe Ala Gly Phe Pro 
        195                 200                 205             


Ser Ala Ala Ala Thr Ala Ala Ala Thr Gly Leu Leu Asp Ser Pro Thr 
    210                 215                 220                 


Ser Ile Thr Pro Pro Pro Ile Leu Ser Ala Asp Asp Leu Leu Gly Ser 
225                 230                 235                 240 


Pro Thr Leu Pro Asp Gly Thr Asn Asn Pro Phe Ala Phe Ser Ser Gln 
                245                 250                 255     


Glu Leu Ala Ser Leu Phe Ala Pro Ser Met Gly Leu Pro Gly Gly Gly 
            260                 265                 270         


Ser Pro Thr Thr Phe Leu Phe Arg Pro Met Ser Glu Ser Pro His Met 
        275                 280                 285             


Phe Asp Ser Pro Pro Ser Pro Gln Asp Ser Leu Ser Asp Gln Glu Gly 
    290                 295                 300                 


Tyr Leu Ser Ser Ser Ser Ser Ser His Ser Gly Ser Asp Ser Pro Thr 
305                 310                 315                 320 


Leu Asp Asn Ser Arg Arg Leu Pro Ile Phe Ser Arg Leu Ser Ile Ser 
                325                 330                 335     


Asp Asp 
        


<210>  185
<211>  6683
<212>  DNA
<213>  homo sapiens

<400>  185
gcatttcttc cttctgcgta tgggacagga ccctttctgg aatgggggtc ttatgaccta       60

caatcaaaca agaacatgga cttcccgtgc ctctggctag ggctgttgct gcctttggta      120

gctgcgctgg atttcaacta ccaccgccag gaagggatgg aagcgttttt gaagactgtt      180

gcccaaaact acagttctgt cactcactta cacagtattg ggaaatctgt gaaaggtaga      240

aacctgtggg ttcttgttgt ggggcggttt ccaaaggaac acagaattgg gattccagag      300

ttcaaatacg tggcaaatat gcatggagat gagactgttg ggcgggagct gctgctccat      360

ctgattgact atctcgtaac cagtgatggc aaagaccctg aaatcacaaa tctgatcaat      420

agtacccgga tacacatcat gccttccatg aacccagatg gatttgaagc cgtcaaaaag      480

cctgactgtt attacagcat cggaagggaa aattataacc agtatgactt gaatcgaaat      540

ttccccgatg cttttgaata taataatgtc tcaaggcagc ctgaaactgt ggcagtcatg      600

aagtggctga aaacagagac gtttgtcctc tctgcaaacc tccatggtgg tgccctcgtg      660

gccagttacc catttgataa tggtgttcaa gcaactgggg cattatactc ccgaagctta      720

acgcctgatg atgatgtttt tcaatatctt gcacatacct atgcttcaag aaatcccaac      780

atgaagaaag gagacgagtg taaaaacaaa atgaactttc ctaatggtgt tacaaatgga      840

tactcttggt atccactcca aggtggaatg caagattaca actacatctg ggcccagtgt      900

tttgaaatta cgttggagct gtcatgctgt aaatatcctc gtgaggagaa gcttccatcc      960

ttttggaata ataacaaagc ctcattaatt gaatatataa agcaggtgca cctaggtgta     1020

aagggtcaag tttttgatca gaatggaaat ccattaccca atgtaattgt ggaagtccaa     1080

gacagaaaac atatctgccc ctatagaacc aacaaatatg gagagtatta tctccttctc     1140

ttgcctgggt cttatataat aaatgttaca gtccctggac atgatccaca catcacaaag     1200

gtgattattc cggagaaatc ccagaacttc agtgctctta aaaaggatat tctacttcca     1260

ttccaagggc aattggattc tatcccagta tcaaatcctt catgcccaat gattcctcta     1320

tacagaaatt tgccagacca ctcagctgca acaaagccta gtttgttctt atttttagtg     1380

agtcttttgc acatattctt caaataaagt aaaatgtgaa actcaaccca catcaccacc     1440

tggaatcagg gattgctcac tccaggttac tgcaacccta actcactcta gtgggacctt     1500

gactggagaa actccacgat cttcctgaag aagagaaatg gatgtttcca aattccacaa     1560

taagcaatat gtggtgataa tgaaaagaat gattcagtct tgacggtgaa tggaagacac     1620

ttacctaaca agtactgctc atttacactc aaattaatct tgaagtagtc ttaaaatgtg     1680

taagaagtta aaacttgaga agcaaaaaaa tgcctgcaaa aagaagatca ttttgtatac     1740

agagaaccgg atgaatataa gcaatgaaga tgaacattta ttgatcttct acatacaaga     1800

cttcaccata aggccaggag cagtggctca caccttgtaa tcccagcact ttgggaggcc     1860

aaggtgggcg gatcaccctg aggtcaggag ttcaaaacca gcctgaccaa catggtgaaa     1920

ccctgtctct actaaatatt agcggggtgt ggtggcgggc acctgtaatc gcagcctttc     1980

aggaggctga gacaggagaa tcgcttgaac cctagaggcg gagtttgcag tgagccgaga     2040

tagtgccatt gtactccagc ttgggcaaca gagtaagact ctgtctcaaa aaaaaaaaaa     2100

caaaaacaaa caaacaaaaa aaacacctca ccatgagtgc tacatgtgaa tagatattaa     2160

gtgccatata taattagttc tcagaagaag ggagaaatga tcataggact gggaattgtt     2220

ttgcaaacgt tctaggagat gtgagagaaa atatgtaacc acatcttagt ggcccaagaa     2280

aatacaggcc tgaagggata agattgtgtc tctatagagc ttcaaagcat acaggtcaat     2340

taagaaagcc cctctctctc cagagccgtt tccctagctt ttggcacctg gatgccacag     2400

tcctccatta ggctgatgac tccaaagatg taactctagc ctcttgcctg agcttcagac     2460

tcgcgtccca ctgcccacag gacacatcca cctggatgtg actcacaggt acctccaacc     2520

catcatgtgg agatactcat cctgttcccc ctagagctgc tcttcctgct gcattctctc     2580

tctcaattac tgggaccacc aagctaggaa cctgggagtc atccttgata ctttctcttc     2640

ctccttaatc ctgtgtattc agcaagtaac taaaggttgg tgttggccag gcatggtggc     2700

tcatgcctgt aatcccagca ttttgggagg ccaaggcggg cggatcactt gaggtcagga     2760

gctcaagacc agcctggcca acatggtgaa accccatctc tactaaaaaa aaaaaaaaaa     2820

ttagtcgggc gtggtggtgc atgcctgtaa tcccagctac tggggaggct gaggcaggag     2880

aatcgcttga acctgggagg cagaggttgc agtgagccgg gattgcgcca ttgtactcca     2940

gcctgggtga agaagtgaga ctctgtctta aaaaaaaaaa ttggtgctga taaatattga     3000

tgaattctgc tctctgctct ctatggttgt caacactgca gagttgaggc ctcatatctc     3060

acctgcactg ctgcaacagc ttactggtcc cttgctccca gccttctcct cttcagtcca     3120

tcgtccacac agcactgggg aaggggagcc acttgaaaca aaagtcaaca actggttgta     3180

gttcataaac acagagctgt ttgtgtcccc tgtatctgga atgccattat gacccactac     3240

attttttctt tcctacccct cttaaaactc agttcaggta gcagctccac taggaagcct     3300

tggctgacca taatcccatt caattccatt tcacctcttc gcaggcagtc tggggttagg     3360

gaccctttct ctttgctccc caaaataaac tggttatctc tactattgga tttacaacat     3420

tgtattataa tcttctccat gtgtgccttc tctagtagaa tgtgagctct ttgaggccaa     3480

ggtctattta atttgtttga aaaattcatt gttatatcct caaagcctag cacatagtag     3540

gtactgaatg aatgaatgaa caaggggtgc caggagactg ctactcccag tccttcccag     3600

aaactgccta gggctttgag tcattttatg aagctaggtc ttaatgcgta ggcaacctcc     3660

cagctcacta tgaacgctga cagaagagtg ttttcatgtc tataatcaag aattccagat     3720

acattccttt tactgaacct tgaattgatc ctaagattgg tagtaaaggt attatgttac     3780

ctcctaacag cactacaaag tacctttttt tatcagaaaa aaattttacc attaggactc     3840

aatttgaagt actaatgctt ctcaagttct ccactatgag agttaccctg tattagaccg     3900

ttacctataa gaattaaggg gtaaagcact aaacagaaaa gaaaaaaaaa atagcaactc     3960

tggtgagcag atttctttcc tttcttcctt ccttctcctc ttcctacctt cctccctcct     4020

ttccctctcc tccccttctc tccctttccc tccccttccc ttccttttct tctttcctcc     4080

gctcccctcc ccttccctcc ccttcccatc cttctttctc ttttttttac ttaatcccca     4140

gtgtgacagt aatataggct gatttctaga agtgtggtgt attactcatg gaaagtgagt     4200

tgccttggtt attactttca attgaaagtt ctatgggatc tagaaatgag acatactggc     4260

atggagagtg agaacgacaa aggaatgaag agctacagga gcatttaggc catttctatg     4320

ccaagcttat tctacatgca caaaatcata catgttaata aatataaaca aattggaggc     4380

ttatttaaac caattatgaa atctggtaat ttgtgcagca gcaatagatg ataaccaaaa     4440

aaaactcata ataatctgaa tatcttgatc atttgtattt aaagaagcag taattatata     4500

cttgaaagta cataatatag tattgcaaaa atgactttgg tatattacaa attaaaagta     4560

tataagatga aacttgattt gctatcaagc cccaagcaat ttttcaactg ggcattgaat     4620

tctaactttt ctaagatagc aatttttgaa gagacacgaa caaaaatctg aattagttca     4680

tgagccttaa tgtaaatctc ttgctgaaat agtttttaaa atcagaattt agttatctat     4740

cagactcaaa atcatttaaa gactaacaaa acacaatcat gatattctaa ctgtggtcaa     4800

accaggtacc caagccacct ccctgcccaa cgcctttccg gcttttcccc tccctcttgg     4860

gctggtggtt atgctcctcc agctctagtt cagctataat tccttttata gagaaaccaa     4920

cctgatacac actttcatga tgggagaaaa atgtgggagt gaaatggtat ttagaaagca     4980

gcagtcaggc acggtggctc atgcctgtaa tcccagcact ttgggaggct gaggcaggcg     5040

gatcacttga ggtcaggagc tcgagaccag cctggccaac acggtgaaac cccatctcta     5100

ctaaaaaaaa atacaaaaat tagccgggcg tggtggcagg cacctgtaat cccagctact     5160

tgggaggctg aggcaggaga aatcgcctga acccagaagg cagaggttgc agtgagccaa     5220

gatcacatca ctgcactgca ctccagccgg ggtgacagag cgaacctctg tctcaaaaaa     5280

aaaaaaagaa aaaagaaaga aagaaaaaag gcagaagccc tggattcaaa tccgccacac     5340

attcagtttc tttatctgta aaatggagac caccccccgc cacgctgaac ggtgattctg     5400

tgactggtaa gagatgctac atttttggtg cttgttcagg tggaggaaag atgatagtta     5460

acactcaggt aataagtatt ttgaaggcag tataatatac cttcttaaag agtataccta     5520

ctcaaatgtt ggtaaatgtt gacatgattg aatctaaatg gcaaagagta ttttagaaaa     5580

acattaagtc cctgcagata aatgacagtg ttgatttgga tgcttaatta cattcagaca     5640

tgaactgttg gatgtatctg aaatgttaaa agctttttct caacatttcc aaaagtcttt     5700

ccaagaaatc aatgttatgt tttgttccag aagcaaattt gcatttgtga tctgtttcta     5760

aaaatggtac aagttagctc tgtttagaaa gtaaaaatat ctgatgttag attggaagta     5820

tctcttcctg gggaatccag aaagataagc atagcatatt gtcttactgc aatagataag     5880

ttgcttattg agaagtctgg ttgttattct atatggtaac aatacagttg atgtatattt     5940

tatgatagat cctttatatt ttcctcatga ctttagaagg gggaaggggg agaaaattat     6000

gatgaccaga ctagttaaag agcattgaaa gtccacagta ctgtagctaa agtagaagtt     6060

tgggtttgtt atagacttta cattatatca actaataagc agatactgta cagtattgct     6120

caccatttta tcatactttt gcatatgaac tactccattg ccttttatag atgttttata     6180

gctgatctta ccagttttcc tggtaacttt ttttatttct tttttttttt tttgagacgg     6240

agtctcgccc taacacccag gttggagtgc agtgccgtga tctcggctca ctgcaacctc     6300

tgcctcccgg gttcaagcaa ttctcctgtc tcagcctccc gagtacctgg gactaccggt     6360

gcctgtctcc acgcccggct aattttttgt atttgtagta gagacggggt ttcaccgtgt     6420

tagccaggat ggtctcgatc tcctgacctc atgatctgcc tgcctctgcc tggacctccc     6480

aaagtgctgg gattacaggc gtgagccccc gcgcccagcc actttcttta atactataac     6540

taagaattta ttaaaatgca caaattgtct aagactgtaa agtttattgg ggagaggcca     6600

tgactacctc tgaatttagt aaatttaaaa tatttctgat tctcaataaa gaactaatat     6660

ccatataaaa aaaaaaaaaa aaa                                             6683


<210>  186
<211>  443
<212>  PRT
<213>  homo sapiens

<400>  186

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr 
                245                 250                 255     


Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp 
            260                 265                 270         


Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro 
        275                 280                 285             


Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu 
    290                 295                 300                 


Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe 
305                 310                 315                 320 


Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp 
                325                 330                 335     


Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly 
        355                 360                 365             


His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn 
    370                 375                 380                 


Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu 
385                 390                 395                 400 


Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr 
                405                 410                 415     


Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu 
            420                 425                 430         


Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys 
        435                 440             


<210>  187
<211>  1641
<212>  DNA
<213>  homo sapiens

<400>  187
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagct ttacaacaaa tacccagatg ctgtggccac atggctaaac      300

cctgacccat ctcagaagca gaatctccta gccccacaga atgctgtgtc ctctgaagaa      360

accaatgact ttaaacaaga gacccttcca agtaagtcca acgaaagcca tgaccacatg      420

gatgatatgg atgatgaaga tgatgatgac catgtggaca gccaggactc cattgactcg      480

aacgactctg atgatgtaga tgacactgat gattctcacc agtctgatga gtctcaccat      540

tctgatgaat ctgatgaact ggtcactgat tttcccacgg acctgccagc aaccgaagtt      600

ttcactccag ttgtccccac agtagacaca tatgatggcc gaggtgatag tgtggtttat      660

ggactgaggt caaaatctaa gaagtttcgc agacctgaca tccagtaccc tgatgctaca      720

gacgaggaca tcacctcaca catggaaagc gaggagttga atggtgcata caaggccatc      780

cccgttgccc aggacctgaa cgcgccttct gattgggaca gccgtgggaa ggacagttat      840

gaaacgagtc agctggatga ccagagtgct gaaacccaca gccacaagca gtccagatta      900

tataagcgga aagccaatga tgagagcaat gagcattccg atgtgattga tagtcaggaa      960

ctttccaaag tcagccgtga attccacagc catgaatttc acagccatga agatatgctg     1020

gttgtagacc ccaaaagtaa ggaagaagat aaacacctga aatttcgtat ttctcatgaa     1080

ttagatagtg catcttctga ggtcaattaa aaggagaaaa aatacaattt ctcactttgc     1140

atttagtcaa aagaaaaaat gctttatagc aaaatgaaag agaacatgaa atgcttcttt     1200

ctcagtttat tggttgaatg tgtatctatt tgagtctgga aataactaat gtgtttgata     1260

attagtttag tttgtggctt catggaaact ccctgtaaac taaaagcttc agggttatgt     1320

ctatgttcat tctatagaag aaatgcaaac tatcactgta ttttaatatt tgttattctc     1380

tcatgaatag aaatttatgt agaagcaaac aaaatacttt tacccactta aaaagagaat     1440

ataacatttt atgtcactat aatcttttgt tttttaagtt agtgtatatt ttgttgtgat     1500

tatctttttg tggtgtgaat aaatctttta tcttgaatgt aataagaatt tggtggtgtc     1560

aattgcttat ttgttttccc acggttgtcc agcaattaat aaaacataac cttttttact     1620

gcctaaaaaa aaaaaaaaaa a                                               1641


<210>  188
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  188

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  189
<211>  6791
<212>  DNA
<213>  homo sapiens

<400>  189
ggacccgccg cagagccagg taagcggccc tcgcaggcct cgggccgggc acggggacta       60

ggatgccgcc ggggacgggg atgaggccgt gaggatgcgc gaagggccgc cccctctccc      120

ggcccgcggg gggcgctcgg cgctgtgccc gggctagccc gaggcccggc ctcaggcccc      180

acgcggcccc tttccccctc ggacccaccg tgcgtcccgc ggcacggacc ctctgcccgg      240

gaggcgcggg cacatcgcgg agctccggcg cggcggcggg ggagccgcag cagcaggtgc      300

gcggcctggg ccggagccgc cagcccggga ggaggcggtg ctaatctcag ggaccggaga      360

cacctgcagc ggccgcgagc ccggcagcgg cgacatcctc gagtccagtg cagaatacag      420

aaactgcagc catgaccacg cacgtcaccc tggaagatgc cctgtccaac gtggacctgc      480

ttgaagagct tcccctcccc gaccagcagc catgcatcga gcctccacct tcctccatca      540

tgtaccaggc taactttgac acaaactttg aggacaggaa tgcatttgtc acgggcattg      600

caaggtacat tgagcaggct acagtccact ccagcatgaa tgagatgctg gaggaaggac      660

atgagtatgc ggtcatgctg tacacctggc gcagctgttc ccgggccatt ccccaggtga      720

aatgcaacga gcagcccaac cgagtagaga tctatgagaa gacagtagag gtgctggagc      780

cggaggtcac caagctcatg aagttcatgt attttcagcg caaggccatc gagcggttct      840

gcagcgaggt gaagcggctg tgccatgccg agcgcaggaa ggactttgtc tctgaggcct      900

acctcctgac ccttggcaag ttcatcaaca tgtttgctgt cctggatgag ctaaagaaca      960

tgaagtgcag cgtcaagaat gaccactctg cctacaagag ggcagcacag ttcctgcgga     1020

agatggcaga tccccagtct atccaggagt cgcagaacct ttccatgttc ctggccaacc     1080

acaacaggat cacccagtgt ctccaccagc aacttgaagt gatcccaggc tatgaggagc     1140

tgctggctga cattgtcaac atctgtgtgg attactacga gaacaagatg tacctgactc     1200

ccagtgagaa acatatgctc ctcaaggtga tgggctttgg cctctaccta atggatggaa     1260

atgtcagtaa catttacaaa ctggatgcca agaagagaat taatcttagc aaaattgata     1320

aattctttaa gcagctgcag gtggtgcccc ttttcggcga catgcagata gagctggcca     1380

gatacattaa gaccagtgct cactatgaag agaacaagtc caagtggacg tgcacccaga     1440

gcagcatcag cccccagtac aatatctgcg agcagatggt tcagatccgg gatgaccaca     1500

tccgcttcat ctccgagctc gctcgctaca gcaacagtga ggtggtgacg ggctcagggc     1560

tggacagcca gaagtcagac gaggagtatc gcgagctctt cgacctagcc ctgcggggtc     1620

tgcagcttct atccaagtgg agcgcccacg tcatggaggt gtactcttgg aagctggttc     1680

atcccacaga caagttctgc aacaaggact gtcctggcac cgcggaggaa tatgagagag     1740

ccacacgcta caattacacc agtgaggaaa aatttgcctt cgttgaggtg atcgccatga     1800

tcaaaggcct gcaggtgctc atgggcagga tggagagcgt cttcaaccag gccatcagga     1860

acaccatcta cgcggcattg caggacttcg cccaggtgac gctgcgtgag cccctgcggc     1920

aggcggtacg gaagaagaag aatgtcctca tcagcgtcct acaggcaatt cgaaagacca     1980

tctgtgactg ggagggaggg cgagagcccc ctaatgaccc atgcttgaga ggggagaagg     2040

accccaaagg tggatttgat atcaaggtgc cccggcgtgc tgtggggcca tccagcacac     2100

agctgtacat ggtgcggacc atgcttgaat cactcattgc agacaaaagc ggctccaaga     2160

agaccctgag gagcagcctg gatggaccca ttgtcctcgc catagaggac tttcacaaac     2220

agtccttctt cttcacacat ctgctcaaca tcagtgaagc cctgcagcag tgttgtgacc     2280

tctcccagct ctggttccga gaattcttcc tggagttaac catgggccga cgaatccagt     2340

tccccatcga gatgtccatg ccctggattc taacggacca tatcctggaa accaaagaac     2400

cttccatgat ggagtatgtc ctctaccctc tggatctgta caacgacagc gcctactatg     2460

ctctgaccaa gtttaaaaag cagttcctgt acgatgagat agaagctgag gtgaacctgt     2520

gttttgatca gtttgtctac aagctggcag accagatctt tgcttactac aaagccatgg     2580

ctggcagtgt cctgttggat aaacgttttc gagctgagtg taagaattat ggcgtcatca     2640

ttccgtatcc accgtccaat cgctatgaaa cactgctgaa gcagagacac gtccagctgt     2700

tgggtagatc aattgacttg aacagactca ttacccagcg catctctgcc gccatgtata     2760

aatccttgga ccaagctatc agccgctttg agagtgagga cctgacctcc attgtggagc     2820

tggagtggct gctggagatt aaccggctca cgcatcggct gctctgtaag catatgacgc     2880

tggacagctt cgatgccatg ttccgagagg ccaatcacaa tgtgtccgcc ccctatggcc     2940

gtatcaccct gcatgtcttc tgggaactga actttgactt tctccccaac tactgctaca     3000

atgggtccac taaccgtttt gtgcggactg ccattccttt cacccaagaa ccacaacgag     3060

acaaacctgc caacgtccag ccttattacc tctatggatc caagcctctc aacattgcct     3120

acagccacat ctacagctcc tacaggaatt tcgtggggcc acctcatttc aagactatct     3180

gcagactcct gggttatcag ggcatcgctg tggtcatgga ggaactgcta aagattgtga     3240

agagcttgct ccaaggaacc attctccagt atgtgaaaac actgatagag gtgatgccca     3300

agatatgccg cttgccccga catgagtatg gctccccagg gatcctggag ttcttccacc     3360

accagctgaa ggacatcatt gagtacgcag agctcaaaac agacgtgttc cagagcctga     3420

gggaagtggg caatgccatc ctcttctgcc tcctcataga gcaagctctg tctcaggagg     3480

aggtctgcga tttgctccat gccgcaccct tccaaaacat cttgcctaga gtctacatca     3540

aagaggggga gcgcctggag gtccggatga aacgtctgga agccaagtat gccccgctcc     3600

acctggtccc tctgatcgag cggctgggga cccctcagca aatcgccatt gctcgcgagg     3660

gtgacctcct gaccaaggag cggctgtgct gtggcctgtc catgttcgag gtcatcctga     3720

cccgcattcg gagctacctg caggacccca tctggcgggg cccaccgccc accaatggcg     3780

tcatgcacgt cgatgagtgt gtggagttcc accggctgtg gagcgccatg cagttcgtgt     3840

actgcatccc tgtgggaacc aacgagttca cagctgagca gtgtttcggc gatggcttga     3900

actgggctgg ttgctccatc attgtcctgc tgggccagca gcgtcgcttt gacctgttcg     3960

acttctgtta ccacctgcta aaagtgcaga ggcaggacgg gaaggatgaa atcattaaga     4020

atgtgcccct gaagaagatg gccgaccgga tcaggaagta tcagatcttg aacaatgagg     4080

tttttgccat cctgaacaaa tacatgaagt ccgtggagac agacagttcc actgtggagc     4140

atgtgcgctg cttccagcca cccatccacc agtccttggc caccacttgc taagcagaag     4200

atcctgcaga cccttatctg gaggaggaag agaagcagga gagagaaagc cacagccagc     4260

ctgccatagg atccaactgg acaacgtgtg ggatggacct ggaaacaagc acctccccaa     4320

acacatcacc actccctagg gcggggcctg tgcatgctct cccatgacat ctccatgctg     4380

gtttctccat agcataaatg aaaaaaaaaa aaaaaaagta aacagggcag tgtgtgcttt     4440

ttcttttctc ccccctcaac tatattaaga actcctagtt tcaccctttc tccatcccat     4500

catcccacct atctgtggtt gcttcccaag acctcctccc aagatagaca tctcctaccc     4560

agtgcccttg tgtgacccca ggactcaagt ctcagactgt gaacagatgt ggccatgccc     4620

agagacgcca gcctggccag aagggcatgc ctcagcttac tacttcatct ctcctggttc     4680

cctccctgca gtgccccggg tgtcatcttc tcccactctg ggtaccaggg attctaccac     4740

ataggcttcc caaagcccca ttctaactcc cctctctcag ggaagcccta gagagaggtc     4800

caaaaagcat tcacagctgt atcacactct atgcaggtgg ggtaggagac tgatcaggcc     4860

tgctgtgggg aagcagtatg tatgaacaca gccagaaatg tcatagtcca aacaggatgc     4920

tttcaggcca tctcagctgc ttgatggtga gatggttccc ttattccttc aggaaaggct     4980

tagcattggg ccacataggg gaagcagctt tgaacaaatc agtcatagca ctgcctatag     5040

cattagccag tgaccaaatt agggacaacg tcttggcaca gaattgctta tcaaggaaca     5100

tttccacaag aaagaaaata ttaaggggtt atttccacag aagcccaaaa cgtcttggaa     5160

acacagaggt gaggaggagg aatagtaatt gtcaatgagc ttttaatacc aagatacacc     5220

ccctgccccc aaagaagagt cctcttttag ggaatcagaa ccttcattgt cctagaagct     5280

gaaagattct tggaacattt tagcttttac tctcaacttg ctgttctctt tacattcctt     5340

aagttagact ttcgggtgtg gcttctctcc caggggtaac atttacttcc attttctaga     5400

ctgaaccaaa agtcttctgc agaatctccc accgagtgtg gtaagaagga aggacaaaag     5460

gctttaggat ataaatttca tgttacagag catgtcattg tcaaaggaaa tctgtggccc     5520

tgagatttta agaacataaa atgtgacatt tgatatttct ccagcccagg gaagtaagat     5580

ggttagcaat ggttgcctta atcaaatggt cccattttta accccaaagg aagtgcccac     5640

agcaagaggt ttgtgtgatg cacttatgtc ctccggtgag gaaagggggc cacatatgaa     5700

aggcccctta ggtcagatcc tgagagtagc acatttgagt gcagattcct gggccccacc     5760

tcaaacctac taattctgaa tctctgggaa tagggccagg aaatctgccc tttctacaaa     5820

ctacccaagt tgttctgttg cacatcaatg tttgggaacc actgctgtaa gggaatcatt     5880

ctggtcacct tgagctttga gctaccacta agccatgaaa gaaaatacat catacaggga     5940

agagagaagg gaggaggttc caagtagtaa ctggcagatc ctcctgtctg gaggtaccac     6000

cttctattct ggtttctgac ttttccttct tgatgaccat agatgtgttc cagaggcaaa     6060

agagacacat tatcccagat ggcagaacat gctttcaaaa catataaaat gtcaaagttc     6120

cagatccttc tacatcttta gtcctgtctg aggatggtag ctggctctct gtagctgata     6180

gatggctaga gttccatcca aatccttgac cacgacttca tggagatttg aataatctat     6240

ttgatgagat ttctatttca ataacccacc tctctcaccc cacattcata tccctaaatt     6300

tgaccctctg ggccgagtca cattaccttc aggagacttg atcccagtag actgaggtct     6360

tccctttcag cagaaagatt tcatttccct ggcttgccag tggcactgat ttccgaacac     6420

ccaatgagtt taatattctt tcctccttgg cattactgcc ccagcctctt tttatttttt     6480

ttgtgtgtgt ctaataacca ggaaaaaaat aaagcttagg ttttaaaaag ttttaaaaat     6540

aatctgtttc agaaactgtc aaatgtacca tatttgtatt aagagttgtt gggaattttt     6600

gtacaatgaa tttacattta tttatggtga catatttacg cttgtgatca aataatgatg     6660

ttaaattctt aaatcatatt tgctatgcag ctgaagatga tattttgatt tgtattttgg     6720

gggtacctgt gttgagttga taaacatttc catcttcatt aaaactgctt ccaaactagt     6780

aaaaccagca a                                                          6791


<210>  190
<211>  1253
<212>  PRT
<213>  homo sapiens

<400>  190

Met Thr Thr His Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Thr Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Thr Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly His Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Thr Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Thr Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Thr Lys Leu Met Lys Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser Glu Val Lys Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Leu Thr 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Arg Ile Thr Gln Cys Leu 
    210                 215                 220                 


His Gln Gln Leu Glu Val Ile Pro Gly Tyr Glu Glu Leu Leu Ala Asp 
225                 230                 235                 240 


Ile Val Asn Ile Cys Val Asp Tyr Tyr Glu Asn Lys Met Tyr Leu Thr 
                245                 250                 255     


Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr 
            260                 265                 270         


Leu Met Asp Gly Asn Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys 
        275                 280                 285             


Arg Ile Asn Leu Ser Lys Ile Asp Lys Phe Phe Lys Gln Leu Gln Val 
    290                 295                 300                 


Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys 
305                 310                 315                 320 


Thr Ser Ala His Tyr Glu Glu Asn Lys Ser Lys Trp Thr Cys Thr Gln 
                325                 330                 335     


Ser Ser Ile Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Val Gln Ile 
            340                 345                 350         


Arg Asp Asp His Ile Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn 
        355                 360                 365             


Ser Glu Val Val Thr Gly Ser Gly Leu Asp Ser Gln Lys Ser Asp Glu 
    370                 375                 380                 


Glu Tyr Arg Glu Leu Phe Asp Leu Ala Leu Arg Gly Leu Gln Leu Leu 
385                 390                 395                 400 


Ser Lys Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu Val 
                405                 410                 415     


His Pro Thr Asp Lys Phe Cys Asn Lys Asp Cys Pro Gly Thr Ala Glu 
            420                 425                 430         


Glu Tyr Glu Arg Ala Thr Arg Tyr Asn Tyr Thr Ser Glu Glu Lys Phe 
        435                 440                 445             


Ala Phe Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu Met 
    450                 455                 460                 


Gly Arg Met Glu Ser Val Phe Asn Gln Ala Ile Arg Asn Thr Ile Tyr 
465                 470                 475                 480 


Ala Ala Leu Gln Asp Phe Ala Gln Val Thr Leu Arg Glu Pro Leu Arg 
                485                 490                 495     


Gln Ala Val Arg Lys Lys Lys Asn Val Leu Ile Ser Val Leu Gln Ala 
            500                 505                 510         


Ile Arg Lys Thr Ile Cys Asp Trp Glu Gly Gly Arg Glu Pro Pro Asn 
        515                 520                 525             


Asp Pro Cys Leu Arg Gly Glu Lys Asp Pro Lys Gly Gly Phe Asp Ile 
    530                 535                 540                 


Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Thr Gln Leu Tyr Met 
545                 550                 555                 560 


Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser Lys 
                565                 570                 575     


Lys Thr Leu Arg Ser Ser Leu Asp Gly Pro Ile Val Leu Ala Ile Glu 
            580                 585                 590         


Asp Phe His Lys Gln Ser Phe Phe Phe Thr His Leu Leu Asn Ile Ser 
        595                 600                 605             


Glu Ala Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg Glu 
    610                 615                 620                 


Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe Pro Ile Glu 
625                 630                 635                 640 


Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu Thr Lys Glu 
                645                 650                 655     


Pro Ser Met Met Glu Tyr Val Leu Tyr Pro Leu Asp Leu Tyr Asn Asp 
            660                 665                 670         


Ser Ala Tyr Tyr Ala Leu Thr Lys Phe Lys Lys Gln Phe Leu Tyr Asp 
        675                 680                 685             


Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr Lys 
    690                 695                 700                 


Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Ala Met Ala Gly Ser Val 
705                 710                 715                 720 


Leu Leu Asp Lys Arg Phe Arg Ala Glu Cys Lys Asn Tyr Gly Val Ile 
                725                 730                 735     


Ile Pro Tyr Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gln Arg 
            740                 745                 750         


His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile Thr 
        755                 760                 765             


Gln Arg Ile Ser Ala Ala Met Tyr Lys Ser Leu Asp Gln Ala Ile Ser 
    770                 775                 780                 


Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile Val Glu Leu Glu Trp Leu 
785                 790                 795                 800 


Leu Glu Ile Asn Arg Leu Thr His Arg Leu Leu Cys Lys His Met Thr 
                805                 810                 815     


Leu Asp Ser Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val Ser 
            820                 825                 830         


Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu Leu Asn Phe 
        835                 840                 845             


Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe Val 
    850                 855                 860                 


Arg Thr Ala Ile Pro Phe Thr Gln Glu Pro Gln Arg Asp Lys Pro Ala 
865                 870                 875                 880 


Asn Val Gln Pro Tyr Tyr Leu Tyr Gly Ser Lys Pro Leu Asn Ile Ala 
                885                 890                 895     


Tyr Ser His Ile Tyr Ser Ser Tyr Arg Asn Phe Val Gly Pro Pro His 
            900                 905                 910         


Phe Lys Thr Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val Val 
        915                 920                 925             


Met Glu Glu Leu Leu Lys Ile Val Lys Ser Leu Leu Gln Gly Thr Ile 
    930                 935                 940                 


Leu Gln Tyr Val Lys Thr Leu Ile Glu Val Met Pro Lys Ile Cys Arg 
945                 950                 955                 960 


Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe His 
                965                 970                 975     


His Gln Leu Lys Asp Ile Ile Glu Tyr Ala Glu Leu Lys Thr Asp Val 
            980                 985                 990         


Phe Gln Ser Leu Arg Glu Val Gly  Asn Ala Ile Leu Phe  Cys Leu Leu 
        995                 1000                 1005             


Ile Glu  Gln Ala Leu Ser Gln  Glu Glu Val Cys Asp  Leu Leu His 
    1010                 1015                 1020             


Ala Ala  Pro Phe Gln Asn Ile  Leu Pro Arg Val Tyr  Ile Lys Glu 
    1025                 1030                 1035             


Gly Glu  Arg Leu Glu Val Arg  Met Lys Arg Leu Glu  Ala Lys Tyr 
    1040                 1045                 1050             


Ala Pro  Leu His Leu Val Pro  Leu Ile Glu Arg Leu  Gly Thr Pro 
    1055                 1060                 1065             


Gln Gln  Ile Ala Ile Ala Arg  Glu Gly Asp Leu Leu  Thr Lys Glu 
    1070                 1075                 1080             


Arg Leu  Cys Cys Gly Leu Ser  Met Phe Glu Val Ile  Leu Thr Arg 
    1085                 1090                 1095             


Ile Arg  Ser Tyr Leu Gln Asp  Pro Ile Trp Arg Gly  Pro Pro Pro 
    1100                 1105                 1110             


Thr Asn  Gly Val Met His Val  Asp Glu Cys Val Glu  Phe His Arg 
    1115                 1120                 1125             


Leu Trp  Ser Ala Met Gln Phe  Val Tyr Cys Ile Pro  Val Gly Thr 
    1130                 1135                 1140             


Asn Glu  Phe Thr Ala Glu Gln  Cys Phe Gly Asp Gly  Leu Asn Trp 
    1145                 1150                 1155             


Ala Gly  Cys Ser Ile Ile Val  Leu Leu Gly Gln Gln  Arg Arg Phe 
    1160                 1165                 1170             


Asp Leu  Phe Asp Phe Cys Tyr  His Leu Leu Lys Val  Gln Arg Gln 
    1175                 1180                 1185             


Asp Gly  Lys Asp Glu Ile Ile  Lys Asn Val Pro Leu  Lys Lys Met 
    1190                 1195                 1200             


Ala Asp  Arg Ile Arg Lys Tyr  Gln Ile Leu Asn Asn  Glu Val Phe 
    1205                 1210                 1215             


Ala Ile  Leu Asn Lys Tyr Met  Lys Ser Val Glu Thr  Asp Ser Ser 
    1220                 1225                 1230             


Thr Val  Glu His Val Arg Cys  Phe Gln Pro Pro Ile  His Gln Ser 
    1235                 1240                 1245             


Leu Ala  Thr Thr Cys 
    1250             


<210>  191
<211>  9467
<212>  DNA
<213>  homo sapiens

<400>  191
gcggccaggg gcgggcggcc gcagagcagc accggccgtg gctccggtag cagcaagttc       60

gaaccccgct cccgctccgc ttcggttctc gctccttcgg cccttgggcc tccaaacacc      120

agtccccggc agctcgttgc gcattgcgct ctccccgcca ccaggatgcc ggtaaccgag      180

aaggatctag ctgaggacgc gccttggaag aagatccagc agaacacgtt cacacgctgg      240

tgcaacgagc acctcaagtg cgtgaacaaa cgcatcggca acctgcagac cgacctgagc      300

gacgggctgc ggctcatcgc gctgctcgag gtgctcagcc agaagcgcat gtaccgcaag      360

taccatcagc ggcccacctt tcgccagatg cagctcgaga atgtgtccgt ggcgctcgag      420

ttcctggacc gtgagagcat caagctcgtg tccatcgata gcaaagccat tgtggatggg      480

aacctgaagc tcatcttggg tctggtgtgg acgctgatcc tccactactc catctccatg      540

cccgtgtggg aggatgaagg ggatgatgat gccaagaagc agacgccaaa gcagaggctg      600

ctggggtgga ttcagaacaa gatcccctac ttgcccatca ccaactttaa ccagaactgg      660

caagacggca aagccctggg agccctggta gacagctgtg ctccaggtct gtgcccagac      720

tgggaatcct gggacccgca gaagcctgtg gataatgcac gagaagccat gcagcaggca      780

gatgactggc tgggtgtccc acaggtcatc actcctgaag aaatcattca cccggatgtg      840

gacgagcact cagttatgac ttacctgtcc cagttcccca aagccaagct caagccgggg      900

gctcctctca aacccaaact caacccgaag aaagccaggg cctatggcag aggaatcgag      960

cccactggaa acatggtgaa gcagccagcc aagttcactg tggacaccat cagcgccggg     1020

caaggagacg tgatggtgtt tgttgaggac ccagaaggga acaaagagga ggcacaagtg     1080

acccctgaca gtgacaagaa caagacatac tctgtggagt atctgcccaa ggtcaccggg     1140

ctacacaaag tcacagtcct ctttgcagga cagcacatct ccaagagccc atttgaagtg     1200

agtgttgaca aggcccaggg agatgccagt aaagtcactg caaaaggtcc agggttggaa     1260

gctgtaggga acatcgccaa taagcccacc tactttgaca tctatacggc aggagctggt     1320

gtgggtgaca ttggtgtgga ggtggaagat ccccagggga agaacaccgt ggagttgctc     1380

gtggaagaca aaggaaacca ggtgtatcga tgtgtgtaca aacccatgca gcctggccct     1440

cacgtggtca agatcttctt tgctggggac actattccta agagtccctt cgttgtgcag     1500

gttggggaag cctgcaatcc aaatgcctgc cgggccagtg gccgaggcct acaacccaaa     1560

ggcgtccgta tccgggagac cacagatttc aaggttgaca ccaaagctgc aggaagtggg     1620

gagctcggtg taaccatgaa gggtcctaag ggtctggagg agctggtgaa gcagaaagac     1680

tttctggatg gggtctacgc attcgagtat taccccagca ccccggggag atacagcatt     1740

gccatcacat gggggggaca ccacattcca aagagcccct ttgaagttca agttggccct     1800

gaagcgggta tgcagaaagt ccgtgcttgg ggccctgggc tccatggtgg gattgtcggg     1860

cggtcagcgg acttcgtggt agaatccatt ggctctgaag tggggtctct ggggtttgcc     1920

attgaaggcc cctctcaggc aaagattgag tacaacgacc agaatgatgg atcgtgtgat     1980

gtcaaatact ggcccaagga gcctggcgaa tatgctgttc acatcatgtg tgacgacgaa     2040

gacatcaagg acagcccgta catggccttc atccacccag ccacgggagg ctacaaccct     2100

gatctggttc gagcatacgg gccaggtttg gagaaatctg gatgcattgt caacaacctg     2160

gccgagttca ctgtggatcc taaggatgct ggaaaagctc ccttaaagat atttgctcag     2220

gatggggaag gccaacgcat tgacatccag atgaagaacc ggatggacgg cacatatgca     2280

tgctcataca ccccggtgaa ggccatcaag cacaccattg ctgtggtctg gggaggcgtg     2340

aacatcccgc acagccccta cagggtcaac atcgggcaag gtagccatcc tcagaaggtc     2400

aaagtgtttg ggccaggtgt ggagagaagt ggtctgaagg caaatgaacc tacacacttc     2460

acggtggact gtactgaggc tggggaaggt gatgtcagtg ttggcattaa gtgtgatgcc     2520

cgggtgttaa gtgaagatga ggaagacgtg gattttgaca ttattcacaa tgccaatgat     2580

acgttcacag tcaaatatgt gcctcctgct gctgggcgat acactatcaa agttctcttt     2640

gcatctcagg aaatccccgc cagccctttc agagtcaaag ttgacccttc ccacgatgcc     2700

agcaaagtga aggcagaagg cccagggctc agcaaagcag gtgtggaaaa tgggaaaccg     2760

acccacttca ctgtctacac caagggggct gggaaagccc cgctcaacgt gcagttcaac     2820

agccctcttc ctggcgatgc agtgaaggat ttggatatca tcgataatta tgactactct     2880

cacacggtta aatatacacc cacccaacag ggcaacatgc aggttctggt gacttacggt     2940

ggcgatccca tccctaaaag ccctttcact gtgggtgttg ctgcaccgct ggatctgagc     3000

aagataaaac tcaatgggct ggaaaacagg gtggaagttg ggaaggatca ggagttcacc     3060

gttgatacca ggggggcagg aggccagggg aagctggacg tgacaatcct cagcccctct     3120

cggaaggtcg tgccatgcct agtgacacct gtgacaggcc gggagaacag cacggccaag     3180

ttcatccctc gggaggaggg gctgtatgct gtagacgtga cctacgatgg acaccctgtg     3240

cccgggagcc cctacacagt ggaggcctcg ctgccaccag atcccagcaa ggtgaaggcc     3300

cacggtcccg gcctcgaagg tggtctcgtg ggcaagcctg ccgagttcac catcgatacc     3360

aaaggagctg gtactggagg tctgggctta acggtggaag gtccgtgcga ggccaaaatc     3420

gagtgctccg acaatggtga tgggacctgc tccgtctctt accttcccac aaaacccggg     3480

gagtacttcg tcaacatcct ctttgaagaa gtccacatac ctgggtctcc cttcaaagct     3540

gacattgaaa tgccctttga cccctctaaa gtcgtggcat cggggccagg tctcgagcac     3600

gggaaggtgg gtgaagctgg cctccttagc gtcgactgct cggaagcggg accgggggcc     3660

ctgggcctgg aagctgtctc ggactcggga acaaaagccg aagtcagtat tcagaacaac     3720

aaagatggca cctacgcggt gacctacgtg cccctgacgg ccggcatgta cacgttgacc     3780

atgaagtatg gtggcgaact cgtgccacac ttccccgccc gggtcaaggt ggagcccgcc     3840

gtggacacca gcaggatcaa agtctttgga ccaggaatag aagggaaaga tgtgttccgg     3900

gaagctacca ccgactttac agttgactct cggccgctga cccaggttgg gggtgaccac     3960

atcaaggccc acattgccaa cccctcaggg gcctccaccg agtgctttgt cacagacaat     4020

gcggatggga cctaccaggt ggaatacaca ccctttgaga aaggtctcca tgtagtggag     4080

gtgacatatg atgacgtgcc tatcccaaac agtcccttca aggtggctgt cactgaaggc     4140

tgccagccat ctagggtgca agcccaagga cctggattga aagaggcctt taccaacaag     4200

cccaatgtct tcaccgtggt taccagaggc gcaggaattg gtgggcttgg cataactgtt     4260

gagggaccat cagagtcgaa gataaattgc agagacaaca aggatggcag ctgcagtgct     4320

gagtacattc ctttcgcacc gggggattac gatgttaata tcacatatgg aggagcccac     4380

atccccggca gccccttcag ggttcctgtg aaggatgttg tggaccccag caaggtcaag     4440

attgccggcc ccgggctggg ctcaggcgtc cgagcccgtg tcctgcagtc cttcacggtg     4500

gacagcagca aggctggcct ggctccgctg gaagtgaggg ttctgggccc acgaggcttg     4560

gtggagccag tgaacgtggt ggacaatgga gatggcacac acacagtaac ctacacccca     4620

tctcaggagg gaccttacat ggtctcagtt aaatatgctg atgaagagat tcctcgcagt     4680

cccttcaagg tcaaggtcct tcccacatat gatgccagca aagtgactgc cagtggcccc     4740

ggccttagtt cctatggtgt gcctgccagt ctacctgtgg actttgcaat tgatgcccga     4800

gatgccgggg aaggcctgct tgctgttcaa ataacggacc aagaaggaaa acccaaaaga     4860

gccattgtcc atgacaataa agatggcacg tatgctgtca cctacatccc cgacaagact     4920

gggcgctata tgattggagt cacctacggg ggtgacgaca tcccactttc tccttatcgc     4980

atccgagcca cacagacggg tgatgccagc aagtgcctgg ccacgggtcc tggaatcgcc     5040

tccactgtga aaactggcga agaagtaggc tttgtggttg atgccaagac tgccgggaag     5100

ggtaaagtga cctgcacggt tctgacccca gatggcactg aggccgaggc cgatgtcatt     5160

gagaatgaag atggaaccta tgacatcttc tacacagctg ccaagccggg cacatatgtg     5220

atctatgtgc gcttcggtgg tgttgatatt cctaacagcc ccttcactgt catggccaca     5280

gatggggaag tcacagccgt ggaggaggca ccggtaaatg catgtccccc tggattcagg     5340

ccctgggtga ccgaagaggc ctatgtccca gtgagtgaca tgaacggcct gggatttaag     5400

ccttttgacc tggtcattcc gtttgctgtc aggaaaggag aaatcactgg agaggtccac     5460

atgccttctg ggaagacagc cacacctgag attgtggaca acaaggacgg cacggtcact     5520

gttagatatg cccccactga ggtcgggctc catgagatgc acatcaaata catgggcagc     5580

cacatccctg agagcccact ccagttctac gtgaactacc ccaacagtgg aagtgtttct     5640

gcatacggtc caggcctcgt gtatggagtg gccaacaaaa ctgccacctt caccatcgtc     5700

acagaggatg caggagaagg tggtctggac ttggctattg agggcccctc aaaagcagaa     5760

atcagctgca ttgacaataa agatgggaca tgcacagtga cctacctgcc gactctgcca     5820

ggcgactaca gcattctggt caagtacaat gacaagcaca tccctggcag ccccttcaca     5880

gccaagatca cagatgacag caggcggtgc tcccaggtga agttgggctc agccgctgac     5940

ttcctgctcg acatcagtga gactgacctc agcagcctga cggccagcat taaggcccca     6000

tctggccgag acgagccctg tctcctgaag aggctgccca acaaccacat tggcatctcc     6060

ttcatccccc gggaagtggg cgaacatctg gtcagcatca agaaaaatgg caaccatgtg     6120

gccaacagcc ccgtgtctat catggtggtc cagtcggaga ttggtgacgc ccgccgagcc     6180

aaagtctatg gccgcggcct gtcagaaggc cggactttcg agatgtctga cttcatcgtg     6240

gacacaaggg atgcaggtta tggtggcata tccttggcgg tggaaggccc cagcaaagtg     6300

gacatccaga cggaggacct ggaagatggc acctgcaaag tctcctactt ccctaccgtg     6360

cctggggttt atatcgtctc caccaaattc gctgacgagc acgtgcctgg gagcccattt     6420

accgtgaaga tcagtgggga gggaagagtc aaagagagca tcacccgcac cagtcgggcc     6480

ccgtccgtgg ccactgtcgg gagcatttgt gacctgaacc tgaaaatccc agaaatcaac     6540

agcagtgata tgtcggccca cgtcaccagc ccctctggcc gtgtgactga ggcagagatt     6600

gtgcccatgg ggaagaactc acactgcgtc cggtttgtgc cccaggagat gggcgtgcac     6660

acggtcagcg tcaagtaccg tgggcagcac gtcaccggca gccccttcca gttcaccgtg     6720

gggccacttg gtgaaggagg cgcccacaag gtgcgggcag gaggccctgg cctggagaga     6780

ggagaagcgg gagtcccagc tgagttcagc atttggaccc gggaagcagg cgctggaggc     6840

ctctccatcg ctgttgaggg ccccagtaag gccgagatta cattcgatga ccataaaaat     6900

gggtcgtgcg gtgtatctta tattgcccaa gagcctggta actacgaggt gtccatcaag     6960

ttcaatgatg agcacatccc ggaaagcccc tacctggtgc cggtcatcgc accctccgac     7020

gacgcccgcc gcctcactgt tatgagcctt caggaatcgg gattaaaagt taaccagcca     7080

gcatcctttg ctataaggtt gaatggcgca aaaggcaaga ttgatgcaaa ggtgcacagc     7140

ccctctggag ccgtggagga gtgccacgtg tctgagctgg agccagataa gtatgctgtt     7200

cgcttcatcc ctcatgagaa tggtgtccac accatcgatg tcaagttcaa tgggagccac     7260

gtggttggaa gccccttcaa agtgcgcgtt ggggagcctg gacaagcggg gaaccctgcc     7320

ctggtgtccg cctatggcac gggactcgaa gggggcacca caggtatcca gtcggaattc     7380

tttattaaca ccacccgagc aggtccaggg acattatccg tcaccatcga aggcccatcc     7440

aaggttaaaa tggattgcca ggaaacacct gaagggtaca aagtcatgta cacccccatg     7500

gctcctggta actacctgat cagcgtcaaa tacggtgggc ccaaccacat cgtgggcagt     7560

cccttcaagg ccaaggtgac aggccagcgt ctagttagcc ctggctcagc caacgagacc     7620

tcatccatcc tggtggagtc agtgaccagg tcgtctacag agacctgcta tagcgccatt     7680

cccaaggcat cctcggacgc cagcaaggtg acctctaagg gggcagggct ctcaaaggcc     7740

tttgtgggcc agaagagttc cttcctggtg gactgcagca aagctggctc caacatgctg     7800

ctgatcgggg tccatgggcc caccaccccc tgcgaggagg tctccatgaa gcatgtaggc     7860

aaccagcaat acaacgtcac atacgtcgtc aaggagaggg gcgattatgt gctggctgtg     7920

aagtgggggg aggaacacat ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt     7980

tttctcaaat cctggagaga gttcttgtgg ttgcttttgt tgcttgtttg taattcattt     8040

tatacaaagc cctccagcct gtttgtgggg ctgaaacccc atccctaaaa tattgctgtt     8100

gtaaaatgcc ttcagaaata agtcctagac tggactcttg agggacatat tggagaatct     8160

taagaaatgc aagcttgttc agggggctga gaagatcctg agtacactag gtgcaaacca     8220

gaactcttgg tggaacagac cagccactgc agcagacaga ccaggaacac aatgagactg     8280

acatttcaaa aaaacaaaac tggctagcct gagctgctgg ttcactcttc agcatttatg     8340

aaacaaggct aggggaagat gggcagagaa aaaggggaca cctagtttgg ttgtcatttg     8400

gcaaaggaga tgacttaaaa tccgcttaat ctcttccagt gtccgtgtta atgtatttgg     8460

ctattagatc actagcactg ctttaccgct cctcatcgcc aacaccccca tgctctgtgg     8520

ccttcttaca cttctcagag ggcagagtgg cagccgggca ccctacagaa actcagaggg     8580

cagagtggca gccaggccca catgtctctc aagtacctgt cccctcgctc tggtgattat     8640

ttcttgcaga atcaccacac gagaccatcc cggcagtcat ggttttgctt tagttttcca     8700

agtccgtttc agtcccttcc ttggtctgaa gaaattctgc agtggcgagc agtttcccac     8760

ttgccaaaga tcccttttaa ccaacactag cccttgtttt taacacacgc tccagccctt     8820

catcagcctg ggcagtctta ccaaaatgtt taaagtgatc tcagaggggc ccatggatta     8880

acgccctcat cccaaggtcc gtcccatgac ataacactcc acacccgccc cagccaactt     8940

catgggtcac tttttctgga aaataatgat ctgtacagac aggacagaat gaaactcctg     9000

cgggtctttg gcctgaaagt tgggaatggt tgggggagag aagggcagca gcttattggt     9060

ggtcttttca ccattggcag aaacagtgag agctgtgtgg tgcagaaatc cagaaatgag     9120

gtgtagggaa ttttgcctgc cttcctgcag acctgagctg gctttggaat gaggttaaag     9180

tgtcagggac gttgcctgag cccaaatgtg tagtgtggtc tgggcaggca gacctttagg     9240

ttttgctgct tagtcctgag gaagtggcca ctcttgtggc aggtgtagta tctggggcga     9300

gtgttggggg taaaagccca ccctacagaa agtggaacag cccggagcct gatgtgaaag     9360

gaccacgggt gttgtaagct gggacacgga agccaaactg gaatcaaacg ccgactgtaa     9420

attgtatctt ataacttatt aaataaaaca tttgctccgt aaagttg                   9467


<210>  192
<211>  2602
<212>  PRT
<213>  homo sapiens

<400>  192

Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Asn Ala Cys  Pro Pro Gly Phe Arg  Pro Trp Val 
    1715                 1720                 1725             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1730                 1735                 1740             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1745                 1750                 1755             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1760                 1765                 1770             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1775                 1780                 1785             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1790                 1795                 1800             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1805                 1810                 1815             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1820                 1825                 1830             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1835                 1840                 1845             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1850                 1855                 1860             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1865                 1870                 1875             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1880                 1885                 1890             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1895                 1900                 1905             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1910                 1915                 1920             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1925                 1930                 1935             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1955                 1960                 1965             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1970                 1975                 1980             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1985                 1990                 1995             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    2000                 2005                 2010             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    2015                 2020                 2025             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    2030                 2035                 2040             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    2045                 2050                 2055             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    2060                 2065                 2070             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    2075                 2080                 2085             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    2090                 2095                 2100             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    2105                 2110                 2115             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    2120                 2125                 2130             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    2135                 2140                 2145             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    2150                 2155                 2160             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    2165                 2170                 2175             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2180                 2185                 2190             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2195                 2200                 2205             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2210                 2215                 2220             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2225                 2230                 2235             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2240                 2245                 2250             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2255                 2260                 2265             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2270                 2275                 2280             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2285                 2290                 2295             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2300                 2305                 2310             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2315                 2320                 2325             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2330                 2335                 2340             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2345                 2350                 2355             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2360                 2365                 2370             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2375                 2380                 2385             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2390                 2395                 2400             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2405                 2410                 2415             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2420                 2425                 2430             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2435                 2440                 2445             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2450                 2455                 2460             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2465                 2470                 2475             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2480                 2485                 2490             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2495                 2500                 2505             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2510                 2515                 2520             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2525                 2530                 2535             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2540                 2545                 2550             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2555                 2560                 2565             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2570                 2575                 2580             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2585                 2590                 2595             


Val Thr  Val Pro 
    2600         


<210>  193
<211>  2440
<212>  DNA
<213>  homo sapiens

<400>  193
ggccgggcgg atcgctgcct gcagggagtc ggggatgcca ggttccagct gagcagcggc       60

cgcccgccag agtgccagtg gctccttgga ggtcgagtcc aaggacgtgg cttgaagccg      120

ggagctgggg cgccggagtc cacgcaccgg ggatggaggc gctgggtgac ctggagggac      180

cacgcgcacc aggaggtgat gatcctgcag gaagtgcagg agagaccccc gggtggcttt      240

cgagagaaca ggtttttgta ctgatatcgg cagcttcggt gaacttaggt tccatgatgt      300

gctattctat acttggaccg tttttcccca aagaggctga aaagaaggga gccagcaata      360

caattatcgg tatgatcttt ggatgttttg ctttgttcga gttgctggca tccttggtat      420

ttggaaacta tcttgtacat attggagcaa aatttatgtt tgtagcagga atgtttgtct      480

caggaggagt tacaattctc tttggtgtat tggaccgagt tccagatggg ccagtattta      540

ttgctatgtg ttttctagtg agagtaatgg atgcagttag ctttgctgca gcaatgactg      600

catcttcttc tatcctggca aaggcttttc caaataacgt ggctacggta ttgggaagtc      660

ttgagacttt ttctggactg gggctaatac taggtcctcc tgtaggtggc tttttgtatc      720

aatcctttgg ctatgaagtg ccttttattg ttctgggatg cgtcgttttg ctgatggtac      780

cactcaatat gtatatttta cccaattacg agtctgatcc aggtgaacac tcattctgga      840

aactgatcgc tttacccaaa gttggcctta tagccttcgt catcaactca ctcagctcgt      900

gttttggctt cctcgatcct actctgtctc tctttgtttt ggagaagttc aatttaccag      960

ctggatatgt gggactagta ttcctgggta tggcactgtc ctatgccatc tcttcaccac     1020

tatttggtct cctaagtgat aaaaggccac ctctaaggaa atggcttctg gtgtttggca     1080

acttaatcac agccgggtgc tacatgctct tagggcctgt cccaatcttg catattaaaa     1140

gtcagctctg gctgctggtg ctgatattag ttgtaagtgg cctctctgct ggaatgagta     1200

taattccaac tttcccggaa attctcagtt gtgcacatga aaatgggttt gaagagggat     1260

taagtacatt gggacttgta tcaggtcttt ttagtgcaat gtggtcaatt ggtgctttta     1320

tgggaccaac gctgggtgga tttctgtatg agaaaattgg ttttgaatgg gcagcagcta     1380

tacaaggtct atgggctctg ataagtggat tagccatggg cttgttttat ctactggagt     1440

attcaaggag aaaaaggtct aaatctcaaa acatcctcag cacagaggag gaacgaacta     1500

ctctcttgcc taatgaaacc tagtccgatg gatcctggat tgatacaagg ttgagaaatg     1560

aatgctcctg gccttaaaca tcaccgtagg aagggttttt aaaattttac gcgcaaaact     1620

ccgtggaccc cgtgccagtg tcttggaagt gtcaacgtgt ttttggatga tcctgtattg     1680

ggctgtactt actgtgatac tgaaaagctg tcctgctgaa gcagctatat ttgaaatatt     1740

aagtatgaaa ggagtaatta aaaacaagca aaacaaaaca agacttagtt tttaaatgac     1800

caaacttgtc cttaaagatg ttgttattaa ctcgagttag ttcttatttc ctctgtttat     1860

tttttattct aagtacactg attctgtgaa tgtacctttt ttattaacag ggaaagaaat     1920

gaattaattt gatatgctct aaatacataa aggtgcttca aaatatgtag aaacattact     1980

atgaaatcag tttttaaaag atatactttc tctttgtcct gaggtttttc ggtcttgttc     2040

aaaaggaaga attcttgcct gccatacaga aactctctag cactccctga ccttaagctt     2100

ttctaaaaat tctgtttgtg tgaaaagtac aagaataaca atacttacaa cttccatttt     2160

tgtaacctac gttcacttat gatctggatt tataaacatt acttggtata acgtttttca     2220

tttcctttaa tgtctctgtt ttttggctct accatctgtt ttgtttttgt ttttatctat     2280

atcttggtag atgtatttca tccctagagc aggtcagcct ccttccccta atgcgaatgc     2340

ttgttttgtt agggaagggc ttcctccaac ttcgtgtgaa attgtgatgt tgaagtgaat     2400

aaatgtctat tgtgtaactc tcatgaaaaa aaaaaaaaaa                           2440


<210>  194
<211>  456
<212>  PRT
<213>  homo sapiens

<400>  194

Met Glu Ala Leu Gly Asp Leu Glu Gly Pro Arg Ala Pro Gly Gly Asp 
1               5                   10                  15      


Asp Pro Ala Gly Ser Ala Gly Glu Thr Pro Gly Trp Leu Ser Arg Glu 
            20                  25                  30          


Gln Val Phe Val Leu Ile Ser Ala Ala Ser Val Asn Leu Gly Ser Met 
        35                  40                  45              


Met Cys Tyr Ser Ile Leu Gly Pro Phe Phe Pro Lys Glu Ala Glu Lys 
    50                  55                  60                  


Lys Gly Ala Ser Asn Thr Ile Ile Gly Met Ile Phe Gly Cys Phe Ala 
65                  70                  75                  80  


Leu Phe Glu Leu Leu Ala Ser Leu Val Phe Gly Asn Tyr Leu Val His 
                85                  90                  95      


Ile Gly Ala Lys Phe Met Phe Val Ala Gly Met Phe Val Ser Gly Gly 
            100                 105                 110         


Val Thr Ile Leu Phe Gly Val Leu Asp Arg Val Pro Asp Gly Pro Val 
        115                 120                 125             


Phe Ile Ala Met Cys Phe Leu Val Arg Val Met Asp Ala Val Ser Phe 
    130                 135                 140                 


Ala Ala Ala Met Thr Ala Ser Ser Ser Ile Leu Ala Lys Ala Phe Pro 
145                 150                 155                 160 


Asn Asn Val Ala Thr Val Leu Gly Ser Leu Glu Thr Phe Ser Gly Leu 
                165                 170                 175     


Gly Leu Ile Leu Gly Pro Pro Val Gly Gly Phe Leu Tyr Gln Ser Phe 
            180                 185                 190         


Gly Tyr Glu Val Pro Phe Ile Val Leu Gly Cys Val Val Leu Leu Met 
        195                 200                 205             


Val Pro Leu Asn Met Tyr Ile Leu Pro Asn Tyr Glu Ser Asp Pro Gly 
    210                 215                 220                 


Glu His Ser Phe Trp Lys Leu Ile Ala Leu Pro Lys Val Gly Leu Ile 
225                 230                 235                 240 


Ala Phe Val Ile Asn Ser Leu Ser Ser Cys Phe Gly Phe Leu Asp Pro 
                245                 250                 255     


Thr Leu Ser Leu Phe Val Leu Glu Lys Phe Asn Leu Pro Ala Gly Tyr 
            260                 265                 270         


Val Gly Leu Val Phe Leu Gly Met Ala Leu Ser Tyr Ala Ile Ser Ser 
        275                 280                 285             


Pro Leu Phe Gly Leu Leu Ser Asp Lys Arg Pro Pro Leu Arg Lys Trp 
    290                 295                 300                 


Leu Leu Val Phe Gly Asn Leu Ile Thr Ala Gly Cys Tyr Met Leu Leu 
305                 310                 315                 320 


Gly Pro Val Pro Ile Leu His Ile Lys Ser Gln Leu Trp Leu Leu Val 
                325                 330                 335     


Leu Ile Leu Val Val Ser Gly Leu Ser Ala Gly Met Ser Ile Ile Pro 
            340                 345                 350         


Thr Phe Pro Glu Ile Leu Ser Cys Ala His Glu Asn Gly Phe Glu Glu 
        355                 360                 365             


Gly Leu Ser Thr Leu Gly Leu Val Ser Gly Leu Phe Ser Ala Met Trp 
    370                 375                 380                 


Ser Ile Gly Ala Phe Met Gly Pro Thr Leu Gly Gly Phe Leu Tyr Glu 
385                 390                 395                 400 


Lys Ile Gly Phe Glu Trp Ala Ala Ala Ile Gln Gly Leu Trp Ala Leu 
                405                 410                 415     


Ile Ser Gly Leu Ala Met Gly Leu Phe Tyr Leu Leu Glu Tyr Ser Arg 
            420                 425                 430         


Arg Lys Arg Ser Lys Ser Gln Asn Ile Leu Ser Thr Glu Glu Glu Arg 
        435                 440                 445             


Thr Thr Leu Leu Pro Asn Glu Thr 
    450                 455     


<210>  195
<211>  2664
<212>  DNA
<213>  homo sapiens

<400>  195
gctatctgag gaagttctgg tagagagaag agctcaagag catgggcaga gtcagctcct       60

gagtgggctg aacgctcccc tcagctcctg cagtgctaat taagggaggg agcagcgggg      120

agcttgcagt gaccaagagg gtgttgaggc taggaggcca cgataaacag gatacgataa      180

aagtccttaa ccaagacgca gatgggaaga agcgttagag cgagcagcac tcacatctca      240

agaaccagcc tttcaaacag tttccagaga tggattatcc tactttactt ttggctcttc      300

ttcatgtata cagagctcta tgtgaagagg tgctttggca tacatcagtt ccctttgccg      360

agaacatgtc tctagaatgt gtgtatccat caatgggcat cttaacacag gtggagtggt      420

tcaagatcgg gacccagcag gattccatag ccattttcag ccctactcat ggcatggtca      480

taaggaagcc ctatgctgag agggtttact ttttgaattc aacgatggct tccaataaca      540

tgactctttt ctttcggaat gcctctgaag atgatgttgg ctactattcc tgctctcttt      600

acacttaccc acagggaact tggcagaagg tgatacaggt ggttcagtca gatagttttg      660

aggcagctgt gccatcaaat agccacattg tttcggaacc tggaaagaat gtcacactca      720

cttgtcagcc tcagatgacg tggcctgtgc aggcagtgag gtgggaaaag atccagcccc      780

gtcagatcga cctcttaact tactgcaact tggtccatgg cagaaatttc acctccaagt      840

tcccaagaca aatagtgagc aactgcagcc acggaaggtg gagcgtcatc gtcatccccg      900

atgtcacagt ctcagactcg gggctttacc gctgctactt gcaggccagc gcaggagaaa      960

acgaaacctt cgtgatgaga ttgactgtag ccgagggtaa aaccgataac caatataccc     1020

tctttgtggc tggagggaca gttttattgt tgttgtttgt tatctcaatt accaccatca     1080

ttgtcatttt ccttaacaga aggagaagga gagagagaag agatctattt acagagtcct     1140

gggatacaca gaaggcaccc aataactata gaagtcccat ctctaccagt caacctacca     1200

atcaatccat ggatgataca agagaggata tttatgtcaa ctatccaacc ttctctcgca     1260

gaccaaagac tagagtttaa gcttattctt gacatgagtg cattagtaat gactcttatg     1320

tactcatgca tggatcttta tgcaattttt ttccactacc caaggtctac cttagatact     1380

agttgtctga attgagttac tttgatagga aaaatacttc attacctaaa atcatttttc     1440

atagaactgt ttcagaaaac ctgactctaa ctggtttata tacaaaagaa aacttactgt     1500

atcatataac agaatgatcc aggggagatt aagctttggg caagggctat ttaccagggc     1560

ttaaatgttg tgtctagaat taagtatggg cataaactgg cttctgaatc cctttccaga     1620

gtgttggatc catttccctg gtcttggcct cactctcatg caggctttcc tcttgtgttg     1680

gcaagatggc tgccaactct tggcaattca tacatccttg tttctgtctg gtagagagtt     1740

tgcttctcaa atggagcaaa caaatttgat tattttttca ttgttaaata ggcaacatga     1800

ccagaaagga tggaatggct taagtaaact aagggttcac ttctagagct gagaagcagg     1860

gtcaaagcac aatactgggc aattcagagc atggttagaa gaggaaaggg gagtctcaaa     1920

gctggagagt ttaccaacaa atattgactg cagtgattaa ccaagacatt tttgttaact     1980

aaaaagtgaa atatgggatg gattctagaa atggggtatc tctgtccata cttctagaat     2040

ccactctatc agcatagtcc agaagaatac ctggcagtag aagaaatgaa tattcaagag     2100

gaagataaat gcgagagggc aatcctttac tattctcata tttatttatc tctcattctg     2160

tatagaattc ttgccgccat cccaggtcta gccttaggag caaatgtagt agatagtcga     2220

ataataaata acttaatgtt ttggacatat tttgtctact tttgagaatt atttttaata     2280

tgtaaattct ctcaaaaggg tcaggcacct agttattatt ttttaatgat tatgtgaaag     2340

ttgaatataa tataccacta aaagtgacag ttgaaagtgg tggcatagga tggtagggta     2400

gaaatttggg agggaaaaaa gaaattggga gggtacaggc aacaggagaa aggaatcaaa     2460

ccacagaaaa atacaaaggg aaacttctgc ttcactattc agacaaagac agccctaatg     2520

acatcaccaa cagtcaaagc aattagagac catacctaat attgtttaaa ttctagatgt     2580

aggctaacaa tgaaaagtat ttgccaaact gaataaaact gtcatggtta ccttgaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaa                                            2664


<210>  196
<211>  336
<212>  PRT
<213>  homo sapiens

<400>  196

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  197
<211>  4220
<212>  DNA
<213>  homo sapiens

<400>  197
tggcggtctt gcaggcgggc ggaccctcgg ccgcgctcgg ggctccggcg ccgccgctcc       60

tcctgctcgg cctgagctgc ccgggctcgg cgcgcgcttg gggcgaggct cggcgggcgc      120

ggacgcgcag catggcggtg gaggacgagg ggctccgggt cttccagagc gtgaagatca      180

agatcggtga agccaaaaac cttccctctt acccggggcc gagcaagatg agggattgct      240

actgcacggt gaacctggac caggaggagg ttttcaggac caaaattgtg gaaaagtcac      300

tctgcccgtt ttacggagaa gacttttact gtgaaattcc tcggagcttt cgtcacctgt      360

ccttctacat tttcgataga gacgttttcc ggagggattc catcataggg aaggtggcca      420

tccagaagga ggacttgcag aagtaccaca acagggacac ctggttccag ctgcagcacg      480

tggacgctga ctcggaagtg cagggcaaag tgcacctgga gctgcggctg agcgaggtca      540

tcacagacac tggggtcgtc tgccacaagc tcgccacacg catcgtcgag tgccagggcc      600

tccccatcgt gaatgggcaa tgtgacccct acgccaccgt gacgctggca ggacccttca      660

gatcagaagc aaagaagacg aaagtgaaga ggaagaccaa caatccccag ttcgatgaag      720

tgttttattt tgaggtgacc cggccctgta gctacagcaa gaagtcccac tttgactttg      780

aggaggaaga cgtggacaag ctcgaaatca gagttgacct ctggaatgcc agtaacctga      840

agtttggaga tgaattcctg ggagaactaa ggatcccgtt gaaagtcctg cggcagtcca      900

gctcctacga ggcgtggtac ttcctccagc cccgggacaa tggtagcaag agcctaaagc      960

cagacgacct gggctccctg cggctgaacg tggtatacac ggaagaccac gtgttttctt     1020

ctgactatta cagccctctg cgggacctgc tgttgaagtc tgcggatgtg gagcccgtgt     1080

cagcgtctgc ggcccacatc ctgggcgagg tttgccggga gaagcaggag gcggccgtcc     1140

cgctggtgcg gctcttccta cactatggca gggtggtgcc attcatcagt gccatcgcca     1200

gcgcggaggt gaagcggacc caggacccca acaccatctt ccgaggaaac tcactggcgt     1260

ccaagtgcat cgacgagacc atgaagctgg cggggatgca ttacctgcat gtcaccctga     1320

agcccgccat cgaggagata tgccagagcc acaaaccctg tgaaatcgac cctgtgaagt     1380

tgaaagacgg agaaaacctt gaaaacaaca tggagaacct acggcagtat gtggaccgcg     1440

tcttccacgc catcactgag tctggggtga gctgcccgac cgtcatgtgt gacatcttct     1500

tctccctccg ggaggcggcg gccaagcgct tccaggatga cccggacgtc aggtacactg     1560

cagtgagcag cttcatcttc ctgaggttct ttgcgcccgc cattctctcc cccaacctct     1620

tccagctcac gccgcaccac acggaccccc agacgtccag gacgctgaca ttgatctcca     1680

agaccgttca gaccctcggc agcctgtcca agtccaaatc tgcgagtttt aaggagtcct     1740

acatggctac attttatgaa ttcttcaatg agcagaaata tgctgatgcg gtgaagaact     1800

tcttggatct gatttcgtcc tcggggagaa gagaccccaa gagtgttgag cagcccatcg     1860

tgcttaaaga agggttcatg atcaagaggg cccaaggacg gaagcgcttt gggatgaaga     1920

attttaagaa gagatggttt cgcttgacca accatgaatt tacctaccac aaaagcaaag     1980

gggaccagcc tctctacagc attcccatcg agaacatcct ggcagtggag aagctggagg     2040

aggagtcttt caaaatgaaa aacatgttcc aggtcatcca gccagagcgt gcgctgtaca     2100

tccaggccaa caactgcgtg gaggccaagg actggatcga cattctcacc aaagtgagcc     2160

agtgcaacca gaagcgcctc accgtctacc acccgtccgc ctacctgagc ggccactggc     2220

tgtgctgtag ggcgccatcc gactcggctc cgggctgctc gccctgcact ggcggcctcc     2280

cagccaacat ccagctggac attgatgggg accgtgagac ggagcgtatc tactccctct     2340

tcaacttgta catgagcaag ctggagaaga tgcaggaggc ctgtgggagc aaatctgtgt     2400

atgacggccc ggagcaggag gagtattcga cgttcgtcat tgacgacccc caggagacct     2460

acaagacgct aaagcaagtc atcgctgggg ttggggcttt ggagcaggag cacgcccagt     2520

ataagaggga caagttcaag aagacgaaat atggaagcca ggagcacccc atcggagaca     2580

agagcttcca gaactacatc cggcagcagt ccgagacctc cactcattcc atttaaagtc     2640

tgcgggacgc gcccagtggc gccagcaagc tgcccatgca aagccgcagc ctttgggagg     2700

gagaagagaa ggaagagcgc agagccggca aagtgagatg cacgccgtcc cggcccatag     2760

acaagtggcg ctggggtttc cctctcccag aaccgctgcc accaccgcca cgccctccgc     2820

agaaagccca cctggccctg tggaacgtgt cgtcatttga ttctgtgctt tttgctcctt     2880

gtttgtgggg atctggggat cagctgaagg atcaggaagt gtgggctgtg ccctagccac     2940

accacagcca gcctcaggga gccacggccc gtctagtcga ctgtgacatg cacctccggc     3000

cgtgtgtgcg tcagtctcgt gcacgtctgt cttgcgtgca cggtgcgtgt gacgctgggc     3060

tctgtggctc tgtgcccggg aggcctgctg gccccgcctc ggctttcggc ttcatcacat     3120

tgggaggttc agagcattac tctcccactg tgcctgccat ccaggcagcc atgggaggcg     3180

gcctccctgt tccactttcg aggttcgttt gattcctggc tgaggggtca gttttatggc     3240

tgggaggtgc agaattacac agaagtccca gtctgaggat gtccttggtg cttgggggat     3300

acgggttctg tccacagagt cccttggagg gaaaggtgtg ggctccagct tctccaggcg     3360

tctgcggagc ccacagttga agcccacatc gttttgctgt tgaatggggt ttaaaatcag     3420

aattaacatt tgccaccccc cgtggaagtt tgaagatttt aaaaatagaa atgtacattt     3480

ttcaagctgt ttttctttat gtttttgaag gaccattttt aattagctct ttgatacaaa     3540

gtaactcaga acgtcaaaac ctatacccac taaagggaag gctgccggga aggcaaatgg     3600

aacaggaatg gagcctgtct caggaaggcc agctgcaggt cctccagaaa atcaaagaag     3660

ggaagaaact ctgagtttga ggtacagggg cttcggggtg cagacgtccc tccagggccc     3720

atggtcagta ttgcacctgt gttatgaacc cccagatgct gtgcagggca ggggcggggg     3780

ctgctgtttt attggggagg ggagcatcct aaaaatgggg tccaggcaga cccctccaga     3840

cctcacactg ccgaggaggc ctttcccaaa gggcgtcctc ccgggatgca gacggcaggt     3900

gtgtgggaag cgccgtttaa atacacagca cgacgtatcc ttgtaccgac ttctcccggt     3960

tcttgtttga aaatactgta gttcaggctc ttgatctaga tggcagatag gaactttctt     4020

gtcacaaaaa tactggagga aaatgttgta aaaatagact tttggacaca cagctgttgg     4080

ggctgcactg agctgcaatt tttaacatgg atttataact taatgtttct gtttataaaa     4140

tactaatgat ttgcaatgta ttttactggc caattaaaac agatgtttta ttctttctga     4200

aaaaaaaaaa aaaaaaaaaa                                                 4220


<210>  198
<211>  834
<212>  PRT
<213>  homo sapiens

<400>  198

Met Ala Val Glu Asp Glu Gly Leu Arg Val Phe Gln Ser Val Lys Ile 
1               5                   10                  15      


Lys Ile Gly Glu Ala Lys Asn Leu Pro Ser Tyr Pro Gly Pro Ser Lys 
            20                  25                  30          


Met Arg Asp Cys Tyr Cys Thr Val Asn Leu Asp Gln Glu Glu Val Phe 
        35                  40                  45              


Arg Thr Lys Ile Val Glu Lys Ser Leu Cys Pro Phe Tyr Gly Glu Asp 
    50                  55                  60                  


Phe Tyr Cys Glu Ile Pro Arg Ser Phe Arg His Leu Ser Phe Tyr Ile 
65                  70                  75                  80  


Phe Asp Arg Asp Val Phe Arg Arg Asp Ser Ile Ile Gly Lys Val Ala 
                85                  90                  95      


Ile Gln Lys Glu Asp Leu Gln Lys Tyr His Asn Arg Asp Thr Trp Phe 
            100                 105                 110         


Gln Leu Gln His Val Asp Ala Asp Ser Glu Val Gln Gly Lys Val His 
        115                 120                 125             


Leu Glu Leu Arg Leu Ser Glu Val Ile Thr Asp Thr Gly Val Val Cys 
    130                 135                 140                 


His Lys Leu Ala Thr Arg Ile Val Glu Cys Gln Gly Leu Pro Ile Val 
145                 150                 155                 160 


Asn Gly Gln Cys Asp Pro Tyr Ala Thr Val Thr Leu Ala Gly Pro Phe 
                165                 170                 175     


Arg Ser Glu Ala Lys Lys Thr Lys Val Lys Arg Lys Thr Asn Asn Pro 
            180                 185                 190         


Gln Phe Asp Glu Val Phe Tyr Phe Glu Val Thr Arg Pro Cys Ser Tyr 
        195                 200                 205             


Ser Lys Lys Ser His Phe Asp Phe Glu Glu Glu Asp Val Asp Lys Leu 
    210                 215                 220                 


Glu Ile Arg Val Asp Leu Trp Asn Ala Ser Asn Leu Lys Phe Gly Asp 
225                 230                 235                 240 


Glu Phe Leu Gly Glu Leu Arg Ile Pro Leu Lys Val Leu Arg Gln Ser 
                245                 250                 255     


Ser Ser Tyr Glu Ala Trp Tyr Phe Leu Gln Pro Arg Asp Asn Gly Ser 
            260                 265                 270         


Lys Ser Leu Lys Pro Asp Asp Leu Gly Ser Leu Arg Leu Asn Val Val 
        275                 280                 285             


Tyr Thr Glu Asp His Val Phe Ser Ser Asp Tyr Tyr Ser Pro Leu Arg 
    290                 295                 300                 


Asp Leu Leu Leu Lys Ser Ala Asp Val Glu Pro Val Ser Ala Ser Ala 
305                 310                 315                 320 


Ala His Ile Leu Gly Glu Val Cys Arg Glu Lys Gln Glu Ala Ala Val 
                325                 330                 335     


Pro Leu Val Arg Leu Phe Leu His Tyr Gly Arg Val Val Pro Phe Ile 
            340                 345                 350         


Ser Ala Ile Ala Ser Ala Glu Val Lys Arg Thr Gln Asp Pro Asn Thr 
        355                 360                 365             


Ile Phe Arg Gly Asn Ser Leu Ala Ser Lys Cys Ile Asp Glu Thr Met 
    370                 375                 380                 


Lys Leu Ala Gly Met His Tyr Leu His Val Thr Leu Lys Pro Ala Ile 
385                 390                 395                 400 


Glu Glu Ile Cys Gln Ser His Lys Pro Cys Glu Ile Asp Pro Val Lys 
                405                 410                 415     


Leu Lys Asp Gly Glu Asn Leu Glu Asn Asn Met Glu Asn Leu Arg Gln 
            420                 425                 430         


Tyr Val Asp Arg Val Phe His Ala Ile Thr Glu Ser Gly Val Ser Cys 
        435                 440                 445             


Pro Thr Val Met Cys Asp Ile Phe Phe Ser Leu Arg Glu Ala Ala Ala 
    450                 455                 460                 


Lys Arg Phe Gln Asp Asp Pro Asp Val Arg Tyr Thr Ala Val Ser Ser 
465                 470                 475                 480 


Phe Ile Phe Leu Arg Phe Phe Ala Pro Ala Ile Leu Ser Pro Asn Leu 
                485                 490                 495     


Phe Gln Leu Thr Pro His His Thr Asp Pro Gln Thr Ser Arg Thr Leu 
            500                 505                 510         


Thr Leu Ile Ser Lys Thr Val Gln Thr Leu Gly Ser Leu Ser Lys Ser 
        515                 520                 525             


Lys Ser Ala Ser Phe Lys Glu Ser Tyr Met Ala Thr Phe Tyr Glu Phe 
    530                 535                 540                 


Phe Asn Glu Gln Lys Tyr Ala Asp Ala Val Lys Asn Phe Leu Asp Leu 
545                 550                 555                 560 


Ile Ser Ser Ser Gly Arg Arg Asp Pro Lys Ser Val Glu Gln Pro Ile 
                565                 570                 575     


Val Leu Lys Glu Gly Phe Met Ile Lys Arg Ala Gln Gly Arg Lys Arg 
            580                 585                 590         


Phe Gly Met Lys Asn Phe Lys Lys Arg Trp Phe Arg Leu Thr Asn His 
        595                 600                 605             


Glu Phe Thr Tyr His Lys Ser Lys Gly Asp Gln Pro Leu Tyr Ser Ile 
    610                 615                 620                 


Pro Ile Glu Asn Ile Leu Ala Val Glu Lys Leu Glu Glu Glu Ser Phe 
625                 630                 635                 640 


Lys Met Lys Asn Met Phe Gln Val Ile Gln Pro Glu Arg Ala Leu Tyr 
                645                 650                 655     


Ile Gln Ala Asn Asn Cys Val Glu Ala Lys Asp Trp Ile Asp Ile Leu 
            660                 665                 670         


Thr Lys Val Ser Gln Cys Asn Gln Lys Arg Leu Thr Val Tyr His Pro 
        675                 680                 685             


Ser Ala Tyr Leu Ser Gly His Trp Leu Cys Cys Arg Ala Pro Ser Asp 
    690                 695                 700                 


Ser Ala Pro Gly Cys Ser Pro Cys Thr Gly Gly Leu Pro Ala Asn Ile 
705                 710                 715                 720 


Gln Leu Asp Ile Asp Gly Asp Arg Glu Thr Glu Arg Ile Tyr Ser Leu 
                725                 730                 735     


Phe Asn Leu Tyr Met Ser Lys Leu Glu Lys Met Gln Glu Ala Cys Gly 
            740                 745                 750         


Ser Lys Ser Val Tyr Asp Gly Pro Glu Gln Glu Glu Tyr Ser Thr Phe 
        755                 760                 765             


Val Ile Asp Asp Pro Gln Glu Thr Tyr Lys Thr Leu Lys Gln Val Ile 
    770                 775                 780                 


Ala Gly Val Gly Ala Leu Glu Gln Glu His Ala Gln Tyr Lys Arg Asp 
785                 790                 795                 800 


Lys Phe Lys Lys Thr Lys Tyr Gly Ser Gln Glu His Pro Ile Gly Asp 
                805                 810                 815     


Lys Ser Phe Gln Asn Tyr Ile Arg Gln Gln Ser Glu Thr Ser Thr His 
            820                 825                 830         


Ser Ile 
        


<210>  199
<211>  3691
<212>  DNA
<213>  homo sapiens

<400>  199
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc      180

aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta      240

gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt      300

attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg      360

gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg      420

aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag      480

cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg      540

gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa      600

gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc      660

aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat      720

gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg      780

gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg      840

ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg      900

agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat      960

acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc     1020

aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg     1080

ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc     1140

agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac     1200

tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca     1260

aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa     1320

tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt     1380

ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta     1440

tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt     1500

gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga     1560

tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta     1620

caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt     1680

taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt     1740

atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat     1800

ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga     1860

ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac     1920

ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc     1980

aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca     2040

gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac     2100

aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa     2160

aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata     2220

tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa     2280

ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc     2340

ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc     2400

ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa     2460

agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc     2520

tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt     2580

tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg     2640

tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg     2700

aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt     2760

cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata     2820

catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat     2880

gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa     2940

aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct     3000

ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg     3060

aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg     3120

tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc     3180

tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca     3240

tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac     3300

agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt     3360

ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata     3420

gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac     3480

tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc     3540

tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt     3600

gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca     3660

gtttaacatc ccagtggaga aagttaaaaa a                                    3691


<210>  200
<211>  290
<212>  PRT
<213>  homo sapiens

<400>  200

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  201
<211>  4900
<212>  DNA
<213>  homo sapiens

<400>  201
taaagtcatc aaaacaacgt tatatcctgt gtgaaatgct gcagtcagga tgccttgtgg       60

tttgagtgcc ttgatcatgt gccctaaggg gatggtggcg gtggtggtgg ccgtggatga      120

cggagactct caggccttgg caggtgcgtc tttcagttcc cctcacactt cgggttcctc      180

ggggaggagg ggctggaacc ctagcccatc gtcaggacaa agatgctcag gctgctcttg      240

gctctcaact tattcccttc aattcaagta acaggaaaca agattttggt gaagcagtcg      300

cccatgcttg tagcgtacga caatgcggtc aaccttagct gcaagtattc ctacaatctc      360

ttctcaaggg agttccgggc atcccttcac aaaggactgg atagtgctgt ggaagtctgt      420

gttgtatatg ggaattactc ccagcagctt caggtttact caaaaacggg gttcaactgt      480

gatgggaaat tgggcaatga atcagtgaca ttctacctcc agaatttgta tgttaaccaa      540

acagatattt acttctgcaa aattgaagtt atgtatcctc ctccttacct agacaatgag      600

aagagcaatg gaaccattat ccatgtgaaa gggaaacacc tttgtccaag tcccctattt      660

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      720

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      780

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac      840

cagccctatg ccccaccacg cgacttcgca gcctatcgct cctgacacgg acgcctatcc      900

agaagccagc cggctggcag cccccatctg ctcaatatca ctgctctgga taggaaatga      960

ccgccatctc cagccggcca cctcaggccc ctgttgggcc accaatgcca atttttctcg     1020

agtgactaga ccaaatatca agatcatttt gagactctga aatgaagtaa aagagatttc     1080

ctgtgacagg ccaagtctta cagtgccatg gcccacattc caacttacca tgtacttagt     1140

gacttgactg agaagttagg gtagaaaaca aaaagggagt ggattctggg agcctcttcc     1200

ctttctcact cacctgcaca tctcagtcaa gcaaagtgtg gtatccacag acattttagt     1260

tgcagaagaa aggctaggaa atcattcctt ttggttaaat gggtgtttaa tcttttggtt     1320

agtgggttaa acggggtaag ttagagtagg gggagggata ggaagacata tttaaaaacc     1380

attaaaacac tgtctcccac tcatgaaatg agccacgtag ttcctattta atgctgtttt     1440

cctttagttt agaaatacat agacattgtc ttttatgaat tctgatcata tttagtcatt     1500

ttgaccaaat gagggatttg gtcaaatgag ggattccctc aaagcaatat caggtaaacc     1560

aagttgcttt cctcactccc tgtcatgaga cttcagtgtt aatgttcaca atatactttc     1620

gaaagaataa aatagttctc ctacatgaag aaagaatatg tcaggaaata aggtcacttt     1680

atgtcaaaat tatttgagta ctatgggacc tggcgcagtg gctcatgctt gtaatcccag     1740

cactttggga ggccgaggtg ggcagatcac ttgagatcag gaccagcctg gtcaagatgg     1800

tgaaactccg tctgtactaa aaatacaaaa tttagcttgg cctggtggca ggcacctgta     1860

atcccagctg cccaagaggc tgaggcatga gaatcgcttg aacctggcag gcggaggttg     1920

cagtgagccg agatagtgcc acagctctcc agcctgggcg acagagtgag actccatctc     1980

aaacaacaac aacaacaaca acaacaacaa caaaccacaa aattatttga gtactgtgaa     2040

ggattatttg tctaacagtt cattccaatc agaccaggta ggagctttcc tgtttcatat     2100

gtttcagggt tgcacagttg gtctctttaa tgtcggtgtg gagatccaaa gtgggttgtg     2160

gaaagagcgt ccataggaga agtgagaata ctgtgaaaaa gggatgttag cattcattag     2220

agtatgagga tgagtcccaa gaaggttctt tggaaggagg acgaatagaa tggagtaatg     2280

aaattcttgc catgtgctga ggagatagcc agcattaggt gacaatcttc cagaagtggt     2340

caggcagaag gtgccctggt gagagctcct ttacagggac tttatgtggt ttagggctca     2400

gagctccaaa actctgggct cagctgctcc tgtaccttgg aggtccattc acatgggaaa     2460

gtattttgga atgtgtcttt tgaagagagc atcagagttc ttaagggact gggtaaggcc     2520

tgaccctgaa atgaccatgg atatttttct acctacagtt tgagtcaact agaatatgcc     2580

tggggacctt gaagaatggc ccttcagtgg ccctcaccat ttgttcatgc ttcagttaat     2640

tcaggtgttg aaggagctta ggttttagag gcacgtagac ttggttcaag tctcgttagt     2700

agttgaatag cctcaggcaa gtcactgccc acctaagatg atggttcttc aactataaaa     2760

tggagataat ggttacaaat gtctcttcct atagtataat ctccataagg gcatggccca     2820

agtctgtctt tgactctgcc tatccctgac atttagtagc atgcccgaca tacaatgtta     2880

gctattggta ttattgccat atagataaat tatgtataaa aattaaactg ggcaatagcc     2940

taagaagggg ggaatattgt aacacaaatt taaacccact acgcagggat gaggtgctat     3000

aatatgagga ccttttaact tccatcattt tcctgtttct tgaaatagtt tatcttgtaa     3060

tgaaatataa ggcacctccc acttttatgt atagaaagag gtcttttaat ttttttttaa     3120

tgtgagaagg aagggaggag taggaatctt gagattccag atcgaaaata ctgtactttg     3180

gttgattttt aagtgggctt ccattccatg gatttaatca gtcccaagaa gatcaaactc     3240

agcagtactt gggtgctgaa gaactgttgg atttaccctg gcacgtgtgc cacttgccag     3300

cttcttgggc acacagagtt cttcaatcca agttatcaga ttgtatttga aaatgacaga     3360

gctggagagt tttttgaaat ggcagtggca aataaataaa tacttttttt taaatggaaa     3420

gacttgatct atggtaataa atgattttgt tttctgactg gaaaaatagg cctactaaag     3480

atgaatcaca cttgagatgt ttcttactca ctctgcacag aaacaaagaa gaaatgttat     3540

acagggaagt ccgttttcac tattagtatg aaccaagaaa tggttcaaaa acagtggtag     3600

gagcaatgct ttcatagttt cagatatggt agttatgaag aaaacaatgt catttgctgc     3660

tattattgta agagtcttat aattaatggt actcctataa tttttgattg tgagctcacc     3720

tatttgggtt aagcatgcca atttaaagag accaagtgta tgtacattat gttctacata     3780

ttcagtgata aaattactaa actactatat gtctgcttta aatttgtact ttaatattgt     3840

cttttggtat taagaaagat atgctttcag aatagatatg cttcgctttg gcaaggaatt     3900

tggatagaac ttgctattta aaagaggtgt ggggtaaatc cttgtataaa tctccagttt     3960

agcctttttt gaaaaagcta gactttcaaa tactaatttc acttcaagca gggtacgttt     4020

ctggtttgtt tgcttgactt cagtcacaat ttcttatcag accaatggct gacctctttg     4080

agatgtcagg ctaggcttac ctatgtgttc tgtgtcatgt gaatgctgag aagtttgaca     4140

gagatccaac ttcagccttg accccatcag tccctcgggt taactaactg agccaccggt     4200

cctcatggct attttaatga gggtattgat ggttaaatgc atgtctgatc ccttatccca     4260

gccatttgca ctgccagctg ggaactatac cagacctgga tactgatccc aaagtgttaa     4320

attcaactac atgctggaga ttagagatgg tgccaataaa ggacccagaa ccaggatctt     4380

gattgctata gacttattaa taatccaggt caaagagagt gacacacact ctctcaagac     4440

ctggggtgag ggagtctgtg ttatctgcaa ggccatttga ggctcagaaa gtctctcttt     4500

cctatagata tatgcatact ttctgacata taggaatgta tcaggaatac tcaaccatca     4560

caggcatgtt cctacctcag ggcctttaca tgtcctgttt actctgtcta gaatgtcctt     4620

ctgtagatga cctggcttgc ctcgtcaccc ttcaggtcct tgctcaagtg tcatcttctc     4680

ccctagttaa actaccccac accctgtctg ctttccttgc ttatttttct ccatagcatt     4740

ttaccatctc ttacattaga catttttctt atttatttgt agtttataag cttcatgagg     4800

caagtaactt tgctttgttt cttgctgtat ctccagtgcc cagagcagtg cctggtatat     4860

aataaatatt tattgactga gtgaaaaaaa aaaaaaaaaa                           4900


<210>  202
<211>  219
<212>  PRT
<213>  homo sapiens

<400>  202

Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val Thr 
1               5                   10                  15      


Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp 
            20                  25                  30          


Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg 
        35                  40                  45              


Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val 
    50                  55                  60                  


Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys 
65                  70                  75                  80  


Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe 
                85                  90                  95      


Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys 
            100                 105                 110         


Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
        115                 120                 125             


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
    130                 135                 140                 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
145                 150                 155                 160 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                165                 170                 175     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            180                 185                 190         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        195                 200                 205             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 


<210>  203
<211>  11994
<212>  DNA
<213>  homo sapiens

<400>  203
cgccaggtcg cgcacagcgc cccgagccca ggcgcctccc cgcccccctc ccgcgctccg       60

cggcggcggc ggcggcggca gcagtagcag caatatggct gttgatgggt gtttggggtg      120

gcgctggcgg cgggaggagc tcccccgagc ccctgcgccg gctgcccgtt gctagctatg      180

gcaaatggtg gcggcggcgg cggcggcagc agcggcggcg gcggcggcgg cggaggcagc      240

agtcttagaa tgagtagcaa tatccacgcg aaccatctca gcctagacgc gtcctcctcc      300

tcctcctcct cctcttcctc ttcttcttct tcctcctcct cttcctcctc gtcctcggtc      360

cacgagccca agatggatgc gctcatcatc ccggtgacca tggaggtgcc gtgcgacagc      420

cggggccaac gcatgtggtg ggctttcctg gcctcctcca tggtgacttt cttcgggggc      480

ctcttcatca tcttgctctg gcggacgctc aagtacctgt ggaccgtgtg ctgccactgc      540

gggggcaaga cgaaggaggc ccagaagatt aacaatggct caagccaggc ggatggcact      600

ctcaaaccag tggatgaaaa agaggaggca gtggccgccg aggtcggctg gatgacctcc      660

gtgaaggact gggcgggggt gatgatatcc gcccagacac tgactggcag agtcctggtt      720

gtcttagtct ttgctctcag catcggtgca cttgtaatat acttcataga ttcatcaaac      780

ccaatagaat cctgccagaa tttctacaaa gatttcacat tacagatcga catggctttc      840

aacgtgttct tccttctcta cttcggcttg cggtttattg cagccaacga taaattgtgg      900

ttctggctgg aagtgaactc tgtagtggat ttcttcacgg tgccccccgt gtttgtgtct      960

gtgtacttaa acagaagttg gcttggtttg agatttttaa gagctctgag actgatacag     1020

ttttcagaaa ttttgcagtt tctgaatatt cttaaaacaa gtaattccat caagctggtg     1080

aatctgctct ccatatttat cagcacgtgg ctgactgcag ccgggttcat ccatttggtg     1140

gagaattcag gggacccatg ggaaaatttc caaaacaacc aggctctcac ctactgggaa     1200

tgtgtctatt tactcatggt cacaatgtcc accgttggtt atggggatgt ttatgcaaaa     1260

accacacttg ggcgcctctt catggtcttc ttcatcctcg ggggactggc catgtttgcc     1320

agctacgtcc ctgaaatcat agagttaata ggaaaccgca agaaatacgg gggctcctat     1380

agtgcggtta gtggaagaaa gcacattgtg gtctgcggac acatcactct ggagagtgtt     1440

tccaacttcc tgaaggactt tctgcacaag gaccgggatg acgtcaatgt ggagatcgtt     1500

tttcttcaca acatctcccc caacctggag cttgaagctc tgttcaaacg acattttact     1560

caggtggaat tttatcaggg ttccgtcctc aatccacatg atcttgcaag agtcaagata     1620

gagtcagcag atgcatgcct gatccttgcc aacaagtact gcgctgaccc ggatgcggag     1680

gatgcctcga atatcatgag agtaatctcc ataaagaact accatccgaa gataagaatc     1740

atcactcaaa tgctgcagta tcacaacaag gcccatctgc taaacatccc gagctggaat     1800

tggaaagaag gtgatgacgc aatctgcctc gcagagttga agttgggctt catagcccag     1860

agctgcctgg ctcaaggcct ctccaccatg cttgccaacc tcttctccat gaggtcattc     1920

ataaagattg aggaagacac atggcagaaa tactacttgg aaggagtctc aaatgaaatg     1980

tacacagaat atctctccag tgccttcgtg ggtctgtcct tccctactgt ttgtgagctg     2040

tgttttgtga agctcaagct cctaatgata gccattgagt acaagtctgc caaccgagag     2100

agccgaagcc gaaagcgtat attaattaat cctggaaacc atcttaagat ccaagaaggt     2160

actttaggat ttttcatcgc aagtgatgcc aaagaagtta aaagggcatt tttttactgc     2220

aaggcctgtc atgatgacat cacagatccc aaaagaataa aaaaatgtgg ctgcaaacgg     2280

cttgaagatg agcagccgtc aacactatca ccaaaaaaaa agcaacggaa tggaggcatg     2340

cggaactcac ccaacacctc gcctaagctg atgaggcatg accccttgtt aattcctggc     2400

aatgatcaga ttgacaacat ggactccaat gtgaagaagt acgactctac tgggatgttt     2460

cactggtgtg cacccaagga gatagagaaa gtcatcctga ctcgaagtga agctgccatg     2520

accgtcctga gtggccatgt cgtggtctgc atctttggcg acgtcagctc agccctgatc     2580

ggcctccgga acctggtgat gccgctccgt gccagcaact ttcattacca tgagctcaag     2640

cacattgtgt ttgtgggctc tattgagtac ctcaagcggg aatgggagac gcttcataac     2700

ttccccaaag tgtccatatt gcctggtacg ccattaagtc gggctgattt aagggctgtc     2760

aacatcaacc tctgtgacat gtgcgttatc ctgtcagcca atcagaataa tattgatgat     2820

acttcgctgc aggacaagga atgcatcttg gcgtcactca acatcaaatc tatgcagttt     2880

gatgacagca tcggagtctt gcaggctaat tcccaagggt tcacacctcc aggaatggat     2940

agatcctctc cagataacag cccagtgcac gggatgttac gtcaaccatc catcacaact     3000

ggggtcaaca tccccatcat cactgaacta gtgaacgata ctaatgttca gtttttggac     3060

caagacgatg atgatgaccc tgatacagaa ctgtacctca cgcagccctt tgcctgtggg     3120

acagcatttg ccgtcagtgt cctggactca ctcatgagcg cgacgtactt caatgacaat     3180

atcctcaccc tgatacggac cctggtgacc ggaggagcca cgccggagct ggaggctctg     3240

attgctgagg aaaacgccct tagaggtggc tacagcaccc cgcagacact ggccaatagg     3300

gaccgctgcc gcgtggccca gttagctctg ctcgatgggc catttgcgga cttaggggat     3360

ggtggttgtt atggtgatct gttctgcaaa gctctgaaaa catataatat gctttgtttt     3420

ggaatttacc ggctgagaga tgctcacctc agcaccccca gtcagtgcac aaagaggtat     3480

gtcatcacca acccgcccta tgagtttgag ctcgtgccga cggacctgat cttctgctta     3540

atgcagtttg accacaatgc cggccagtcc cgggccagcc tgtcccattc ctcccactcg     3600

tcgcagtcct ccagcaagaa gagctcctct gttcactcca tcccatccac agcaaaccga     3660

cagaaccggc ccaagtccag ggagtcccgg gacaaacaga acagaaaaga aatggtttac     3720

agatgaaccg gataatgcct atcccagaaa cattcaaatc aagcccatga gtacccacat     3780

ggctaaccag atcaaccaat ataaatccac aagcagcttg attccaccaa tcagagaagt     3840

tgaagatgaa tgttgactcc caggagacca gaactatttt tttaaagcct gacaaacttc     3900

ataaatggtg atgtgacttt tcttcttaca tgctgaatca ctggtggaaa cgttaggata     3960

agcaagaatt gccagaaaat aaagtagaca gatctttctc tttgtctgcc ttgaatattg     4020

cttccatgta ttttggaaaa gaaaatgatt tcatttataa atgaacatac taaaatagtc     4080

atgtatagcc tctagcattt taaattattt ttatttatta gaaagaaaat atattttttc     4140

ttttcattgt caaatatctt ccctatatct aaacaatgca aaatctaaat gaataagtgg     4200

tcagactcct taatgtgttt ttctcttctt tctctctttt tctttgagga gaatgatggt     4260

caccaccaca attaattgta attaagggaa atgaattatt aaaacaattt taaaatggcc     4320

aatgatgtat acatgtattt tagtaaatcc agaaaagaag actaagggga caggtgaata     4380

cctgctcctc gcctggatgg gtgtgtattt tgatctgcat tgacaccagc tcttaataaa     4440

tggaaactta tttattttca cagttgaaag tcatattttt gtagttctag ttttcattct     4500

gtagttctca cccctttgtt catattttta aagggaagac cttctgctgc ttttctacaa     4560

ttggcagatc aggtttgtct ggccaactaa ggacaccagg agggttgtgg gcacacctgg     4620

gatgtggaag ctgaggacca gatgcacaca aggcattgct ctgtttgctg ttctagtggt     4680

ggagactcct acgtgctgtt atgcttctca ttttatattt ccaaaccacc tgagcgagta     4740

atgtcaactt cgggagggtc tggtggactt tctccccact ccccaagtct cagagctttt     4800

agcctggaag tttgtaaaac tgattagtag ttttacttta ccataggatg tgagagggca     4860

gtcattcttc tcactgagtt tttgtttaaa aaccaggaaa tttctacaat catggagaca     4920

gattttaatt tgcatgctct cctttattta gttgctgggg ccaaacacat gaacttgtta     4980

caacaattta aaaataataa taacaaaagg aaagcaacga atgcacttca tatagactgt     5040

tagaaaaggc ctttgaaaat taccagcagt gaaatcaaat aaattagcca ctttaaactg     5100

cggtcaaaag atttttctag ccatcagatg caattacgat gtctcagagc tctgctatcg     5160

cttgcatgct cggtgtacag tctcccggca actgttttgt tccaatcaac ttagcaagtc     5220

tttcaacttt aaaattatca atctttgata tgatcatcaa ggtctctgga gaagcatgga     5280

tgtaatagtg atttctattt tcttaaaaaa tgtaaactgt ggacacttaa tggaaccaag     5340

ctaaccaaag tatctccccg aagtttcatg atatctagtc cattaactct ttgggccatg     5400

acctgtggta cctagttatg gtagtgcaaa tcagatcaga gcaaagcaat gagatcatca     5460

tgaagacata tgtccactaa gtactccaat taccagcgta ggcaaaatga gcttccacct     5520

ctgtccactc cctgcagagc caatatagtc gtgcttccac ctcgtaggca ttgtcctgca     5580

gtgatttgtc ggactgtggt tactctgtcg tcacattttg tagaattagt tctataaaag     5640

tattgtgaat acaatgtatg tccaattgga ttgtttaaaa actacttata attaatcact     5700

agcctactca gcagactaaa atgatgtcaa cagtctatat tcaggcttat aaacatttct     5760

tggtttccaa cagaagtcaa atgtgtttgt ggggagaacg ttttgctagg attttgacaa     5820

ctttcctgaa agctaggcct tttttacata atgattttgc attggggtca ccttagtata     5880

ttcacgtcaa tccacgctct tctttccttc gtgaaccata gtgggctctt cactcctgct     5940

cgtaataacc acctccaaat ttgttagagt gatttggtct cctctggcag gctgtggtgg     6000

ccacataaag gatcttccat tagagggaca caggacacaa agctccattc ccatgaccct     6060

ctcttccctg tgtctcccct aacaaggcaa tctggaagca gaaatgcaaa ctccagcccc     6120

accacacatc caccgatgca tttgtggcta gaaattttaa tctaaacttt ttttaaaaaa     6180

aatcataata gttaggatag tttcctatag caaagggctc cttgattcat aagcacctcc     6240

cccccaaaaa aaccaaattg gtaaaaattc attttctttt aaatagagca ataagttcat     6300

actgtgttgc cgttgtaata atgaattgtt ctggactaga aaacaaaatg aggcattttg     6360

ttaagggggt aggaaaatga ctgattgttg ggccctttgg caaaagctgg tgcctggtaa     6420

gtagaaacga aatggaaaca gaaataacat ttgtgaaatc actggagggc tcaagcaaat     6480

gccagagctt ctccctggct tgttcctact tgttgagctc tttggccctg agtcccatcc     6540

atctccactg caacagtctg tctttctgcc tacatccgcc tgagaccaag gagggtcttt     6600

ggtacagtcc acattatgag gctctgattt cctatcccag tttagggctc cagaaaagcc     6660

attctcccaa actaatgatt cttgggtgct gtgggtcacc aacaggctgt ttacaaagca     6720

gaaaatatca tcaccatcat aacctttctc cttgagaaaa cttttatttt tgtctaagca     6780

attttatatt ttagaatatc atcttgaacc attataaaac accttaaata aaagtgattg     6840

tgactaaggc acgttggaga acattccaat ctttcctccc aagggttctg gcaccttatg     6900

atgtactttg taaaaaaatt gattgaagat tttaaataaa caggaaatta gaagtgttag     6960

ggttagataa aggaaaagtg aaaaagcata agaaatttgg gactttttca tgttgaaagg     7020

agaaaaagca caagttccct agttaccatt taatatgagg gtgcaagagc cacatttaca     7080

aacaacaaac ttgatcttta aaaatgtttt taaaactctc tgagtctcag tgacttcatt     7140

tgtaaatgag agtgattcat ctagatgact ctaaggtctc tttcaggtcc caggggacgt     7200

gatctaagtt aggagtggga acatgggagt ggctgcttct ccttggctaa gcccatgcag     7260

actattgtgt ccaggactgg aataaaggtc ctttttgctg catcacccag gcaacactcc     7320

cagccttact caggagtggt gaacattttc tgctctggac atagaatagg taggttcatt     7380

cctggtcttt tcactttaga ttctctttag gttcaagatg cagatttctc aatttggaca     7440

cacctgcatc acgttggtca aattttgctg cctgtttcta gggttttctt ctcagtttca     7500

tccctgcctt cccttttttg ttgttttttt tttggttcaa ggcccagctt cagttaatcc     7560

cttcatctct atgccatgtc tccaattcct agtatgtaac tagaggttca agagacccca     7620

aattcctgcc attttcccca tttatgtttc cccatgtgaa tcttcaggaa gtaaccagtc     7680

ttccttctca cttcatttcc tgtcctctgt ttatttggtt attttctttc attaataaac     7740

taaccatctc ttagctactt acattcacaa atgtaatttt aatctattgt gtttcattgt     7800

gaaagagaat ctcattgaag gaaggaagga agaaattgag gaataaaggt aggaagggag     7860

agaaacaaag actatccaac caattgactg agatgtgagc cggcttgact cctaggagac     7920

taagtagatc cattcagctt gaacactgag ttccagggca gaatctgtcc attttctgtt     7980

ttgttcttac ttgctgcttt tggaatggtg gtaaagccac cagtcaccat gagccttgaa     8040

aggaccttca ctaatgagga cttgactcac cctctttaaa aagcaaaaga aacagaattt     8100

acttacaatc ttctggtaaa ttacctttct gatcctctcc ttattcccaa aaggcaattt     8160

ttttaatcca gcagagatga tttagcatat aaatcccagg tcatttgagg aggtgatgac     8220

gctatttgga tttatttatg agacagtagt aattataaat gattcctagg cagtttgtac     8280

tagtttggtc atattggttg tttaagtgga gtctcttctg attgtttgtt tccaataaag     8340

tatcagttgt taataatttc aagatttcca taaaaataag aaaacttgga aaacattttt     8400

aattttattt cttaagagac cacagagcct aattttcaat ttttatggta agcttgctta     8460

aaacatgtat aaaaagaagc ctacatgctc aaaggcagag gcacctttag ccctacaaca     8520

gttggaagct ccatgatatc acagccccac atggatagat tggagaaaga attctgactt     8580

agaccacctg tagcagacct tcctcttttg gcatattttt ttaatcacaa aaaggacctg     8640

agactcccta tctaaagata agccaaactt ggggtataca ttaagaatct gggaagaaag     8700

aaaaaaaaga aaaagatata ataagcagta ttttaaaata ccatgagtta tgggcatgca     8760

tatggtacaa agagtagttc tttgggttga aagaaagaag agtttgcatt gaactgcgta     8820

ggctggcaag aatgcagagg tatacaatgt ttgatgggct ttggaggcat ttcaatagta     8880

aatgggtgac aggactggaa agatgtggaa tatgagggtt ttccagggag atgggactta     8940

atgggccatg atgtatttgt aggaatgtga tttcaataga ttgactattt tgtctactgt     9000

gataagtttg tgtaggggaa ctgaggaaaa ctgagatgag acttcatgga aggggctaca     9060

aagtacagtc taaaggccta gataaagttt gaaacttgat ttagaaagtc atgaaaagcc     9120

actcagagtt ttaagcaaag agtgatgggg cagcaatggc tgtgcatttt tcaggttgaa     9180

agtagtgaga tgtcagttct tcctggaaga tatcatgaga atgcacacaa aactgaacat     9240

tttctcagca gcaaggagtg ctaaagggtg cacactccaa gtcaacaact caccgtgtgc     9300

agcaccttcc tcacacattt tgctttgctt tctgtcacag gaccatcaga cgtagaacgt     9360

cctgactctc ctgaattact agaatgtcag caacaaactc acaaagtaga ttagagggta     9420

ggaatagata cataaatttt taaaaacctg ccaatcatac tgttttctag acagtaatat     9480

aataagaaca tgaggcagga catccacaaa tagtagagaa taattaatag tccagaactg     9540

ccaaatagga attcccctta tgaaaacacc cttgcagcta atcaggtagc ccttgtttag     9600

aaaccaatta gcactcataa aatatttgta caaggagtga gtgggggaga aatgagcaca     9660

atatgggttc tgccatcaat cagcttataa tacaactaaa gaaagaaaac atgctcaaag     9720

caccattaga gaaagggtga gccctaatga catagtttca cattcaatat ggtaggagtt     9780

gaaacaaggg agaaatgctg tggtttgaag tggttcaaca aggtaggatt tctagagaaa     9840

ggggggttta ggagttagat aagtagagga tcagcattct aggtatgaag gcaggattat     9900

ctggcatgtg gcagggtgaa tgatgttaat cagtaactgc taattgatat ttactgagca     9960

gctgctgtgt cctcacgatg gtaagactat tagaggaaga cagcccacct gcctaactgg    10020

gaacacaagg cacacatata ttggaaagat catgttgcac aaaacaggtg ttcaataaat    10080

aatttttgaa taaatgtgaa cactgaatag caaataaatg ttatagatcg taatagttgt    10140

agaagattgg ttgggattgt agggactgga tgtggggcaa tggctgtggg tctagagtat    10200

attcattgtg cagtggacac acacctaatc tgtcctcaag gacagaacca tgtggaggaa    10260

taggaaaaca agagaagcag gcaagaagcg gaggcagtga gtacagcagc taagaaatgt    10320

tacattgggt tcatccagag caagaaaagc tgagagctgt ccgtgaggga aggccacaca    10380

ggcaagagga gtgggacagg ggagtaaagg agtgggctac aacaggccct gcagatgtgg    10440

aagccagacc cacagaggca cttagaaagt gaggatcctg gatgaattat tttagggaga    10500

aagtgtaggt ttagatcagc tggcagatgt gtttgtgggc tacagccaag tttttcagga    10560

ctaagaagga gcaaaataag tagaacttct tgggacagga gatctagggt actccagaac    10620

cagggaaatg agaaacaaga ggggaatttt aagaaagaga gggaagatca tctatgaggt    10680

tggagatgaa aggtgttgga gatggtgagg cacaagtcaa aagactcact cgaagggcag    10740

gaactctgct tatttgtcca tattcccaga gtttgtcatg aggtctggcc cacgtgggca    10800

gtcactcggc cactatgtat cactgtggct gccatggtgg atggaggctg gacagaacct    10860

gtggtgatcg gcagtctttc tggaggactc accagggagg ggtctcaggg tgggcatctc    10920

ctttcacctt cctgtgcatg tcactgcact gttcttcttc cctccctgaa cagcacacac    10980

actgcatcct tagtttcagg ggtctgaaaa caaatgctac gaccaccttg ctttggtggc    11040

ttttctgaac aggcattgtg agaagagatg ttctggccag gtgaaagtgg actttatttt    11100

taggtaggtt tttcagttta gaaaggtttc ctttgcttat cccttgagga cttctgtgct    11160

gctgcttctc ctccatcttg ctagttaaca gaacaggggc agaagtgaca ccaatgctct    11220

cggccatgcc tgccttggga agcactaccg ggccccactg tttagaatct tagatggaaa    11280

tgtacacaag gcattgacac acgcctgcgg gagtgaccca gtgcttccct cccatgggac    11340

tcagggtcag cgtgggaagg cagctggcag ggacaggagc cccgcccgca aggtggactg    11400

agcctcactt ccacacaaaa ccagagtccc atctgcccca gagcgctcgc tctcctcccc    11460

ttccttccgc tcaatgcagc ctgacacgcc tttgaccaga actgcaacat ttcaaacaca    11520

aacccagatc tgttgggaaa tcctaattaa aaacgttgca ttcccaggtg gcacaatcac    11580

atcctgccta aaacttctgg cccacatccc accacccaga tgttgaaaag aaacctttct    11640

ctgcttaaca ccaaaacctg cacttcaagg tttctttagg ggacaaagaa aaaaaaagta    11700

cacacatgca gagttcagcc tacatgttca ttgaggaaaa agagcgtggc ttattcatct    11760

ttcaatcttt tgattgttgg cattatgatt atgattatga ttaattactc tgacctgaca    11820

ggaattgaag aagagactat atgctggtgc tctgaaatga tctacccaac tctgtcatct    11880

gtaacaacca gtgataactc tcttgtcttg taaaaagggt ttgtacataa cttgtacatg    11940

gtttcatttt gtatttttcg cagattaaaa atttatgtat ttgtgttcta aaac          11994


<210>  204
<211>  1182
<212>  PRT
<213>  homo sapiens

<400>  204

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ser Arg Lys Arg Ile Leu Ile Asn Pro Gly Asn His Leu 
                645                 650                 655     


Lys Ile Gln Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys 
            660                 665                 670         


Glu Val Lys Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile 
        675                 680                 685             


Thr Asp Pro Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp 
    690                 695                 700                 


Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly 
705                 710                 715                 720 


Met Arg Asn Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro 
                725                 730                 735     


Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val 
            740                 745                 750         


Lys Lys Tyr Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu 
        755                 760                 765             


Ile Glu Lys Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu 
    770                 775                 780                 


Ser Gly His Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu 
785                 790                 795                 800 


Ile Gly Leu Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His 
                805                 810                 815     


Tyr His Glu Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu 
            820                 825                 830         


Lys Arg Glu Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu 
        835                 840                 845             


Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn 
    850                 855                 860                 


Leu Cys Asp Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp 
865                 870                 875                 880 


Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile 
                885                 890                 895     


Lys Ser Met Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser 
            900                 905                 910         


Gln Gly Phe Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser 
        915                 920                 925             


Pro Val His Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn 
    930                 935                 940                 


Ile Pro Ile Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu 
945                 950                 955                 960 


Asp Gln Asp Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln 
                965                 970                 975     


Pro Phe Ala Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu 
            980                 985                 990         


Met Ser Ala Thr Tyr Phe Asn Asp  Asn Ile Leu Thr Leu  Ile Arg Thr 
        995                 1000                 1005             


Leu Val  Thr Gly Gly Ala Thr  Pro Glu Leu Glu Ala  Leu Ile Ala 
    1010                 1015                 1020             


Glu Glu  Asn Ala Leu Arg Gly  Gly Tyr Ser Thr Pro  Gln Thr Leu 
    1025                 1030                 1035             


Ala Asn  Arg Asp Arg Cys Arg  Val Ala Gln Leu Ala  Leu Leu Asp 
    1040                 1045                 1050             


Gly Pro  Phe Ala Asp Leu Gly  Asp Gly Gly Cys Tyr  Gly Asp Leu 
    1055                 1060                 1065             


Phe Cys  Lys Ala Leu Lys Thr  Tyr Asn Met Leu Cys  Phe Gly Ile 
    1070                 1075                 1080             


Tyr Arg  Leu Arg Asp Ala His  Leu Ser Thr Pro Ser  Gln Cys Thr 
    1085                 1090                 1095             


Lys Arg  Tyr Val Ile Thr Asn  Pro Pro Tyr Glu Phe  Glu Leu Val 
    1100                 1105                 1110             


Pro Thr  Asp Leu Ile Phe Cys  Leu Met Gln Phe Asp  His Asn Ala 
    1115                 1120                 1125             


Gly Gln  Ser Arg Ala Ser Leu  Ser His Ser Ser His  Ser Ser Gln 
    1130                 1135                 1140             


Ser Ser  Ser Lys Lys Ser Ser  Ser Val His Ser Ile  Pro Ser Thr 
    1145                 1150                 1155             


Ala Asn  Arg Gln Asn Arg Pro  Lys Ser Arg Glu Ser  Arg Asp Lys 
    1160                 1165                 1170             


Gln Asn  Arg Lys Glu Met Val  Tyr Arg 
    1175                 1180         


<210>  205
<211>  11628
<212>  DNA
<213>  homo sapiens

<400>  205
aacctctccg cgcgaagacg gcttcagccc tgcagggaaa gaaaagtgca atgattctgg       60

actgagacgc gcttgggcag aggctatgta atcgtgtctg tgttgaggac ttcgcttcga      120

ggagggaaga ggagggatcg gctcgctcct ccggcggcgg cggcggcggc gactctgcag      180

gcggagtttc gcggcggcgg caccagggtt acgccagccc cgcggggagg tctctccatc      240

cagcttctgc agcggcgaaa gccccagcgc ccgagcgcct gagccggcgg ggagcaagta      300

aagctagacc gatctccggg gagccccgga gtaggcgagc ggcggccgcc agctagttga      360

gcgcaccccc cgcccgcccc agcggcgccg cggcgggcgg cgtccaggcg gcatggagaa      420

ggacggcctg tgccgcgctg accagcagta cgaatgcgtg gcggagatcg gggagggcgc      480

ctatgggaag gtgttcaagg cccgcgactt gaagaacgga ggccgtttcg tggcgttgaa      540

gcgcgtgcgg gtgcagaccg gcgaggaggg catgccgctc tccaccatcc gcgaggtggc      600

ggtgctgagg cacctggaga ccttcgagca ccccaacgtg gtcaggttgt ttgatgtgtg      660

cacagtgtca cgaacagaca gagaaaccaa actaacttta gtgtttgaac atgtcgatca      720

agacttgacc acttacttgg ataaagttcc agagcctgga gtgcccactg aaaccataaa      780

ggatatgatg tttcagcttc tccgaggtct ggactttctt cattcacacc gagtagtgca      840

tcgcgatcta aaaccacaga acattctggt gaccagcagc ggacaaataa aactcgctga      900

cttcggcctt gcccgcatct atagtttcca gatggctcta acctcagtgg tcgtcacgct      960

gtggtacaga gcacccgaag tcttgctcca gtccagctac gccacccccg tggatctctg     1020

gagtgttggc tgcatatttg cagaaatgtt tcgtagaaag cctctttttc gtggaagttc     1080

agatgttgat caactaggaa aaatcttgga cgtgattgga ctcccaggag aagaagactg     1140

gcctagagat gttgcccttc ccaggcaggc ttttcattca aaatctgccc aaccaattga     1200

gaagtttgta acagatatcg atgaactagg caaagaccta cttctgaagt gtttgacatt     1260

taacccagcc aaaagaatat ctgcctacag tgccctgtct cacccatact tccaggacct     1320

ggaaaggtgc aaagaaaacc tggattccca cctgccgccc agccagaaca cctcggagct     1380

gaatacagcc tgaggcctca gcagccgcct taagctgatc ctgcggagaa cacccttggt     1440

ggcttatggg tccccctcag caagccctac agagctgtgg aggattgcta tctggaggcc     1500

ttccagctgc tgtcttctgg acaggctctg cttctccaag gaaaccgcct agtttactgt     1560

tttgaaatca atgcaagagt gattgcagct ttatgttcat ttgtttgttt gtttgtctgt     1620

ttgtttcaag aacctggaaa aattccagaa gaagagaagc tgctgaccaa ttgtgctgcc     1680

atttgatttt tctaaccttg aatgctgcca gtgtggagtg ggtaatccag gcacagctga     1740

gttatgatgt aatctctctg cagctgccgg gcctgatttg gtacttttga gtgtgtgtgt     1800

gcatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gagagattct gtgatctttt     1860

aaagtgttac tttttgtaaa cgacaagaat aattcaattt taaagactca aggtggtcag     1920

taaataacag gcatttgttc actgaaggtg attcaccaaa atagtcttct caaattagaa     1980

agttaacccc atgtcctcag catttctttt ctggccaaaa gcagtaaatt tgctagcagt     2040

aaaagatgaa gttttataca cacagcaaaa aggagaaaaa attctagtat attttaagag     2100

atgtgcatgc attctattta gtcttcagaa tgctgaattt acttgttgta agtctatttt     2160

aaccttctgt atgacatcat gctttatcat ttcttttgga aaatagcctg taagcttttt     2220

attacttgct ataggtttag ggagtgtacc tcagatagat tttaaaaaaa agaatagaaa     2280

gcctttattt cctggtttga aattcctttc ttcccttttt ttgttgttgt tattgttgtt     2340

tgttgttgtt attttgtttt tgtttttagg aatttgtcag aaactctttc ctgttttggt     2400

ttggagagta gttctctcta actagagaca ggagtggcct tgaaattttc ctcatctatt     2460

acactgtact ttctgccaca cactgccttg ttggcaaagt atccatcttg tctatctccc     2520

ggcacttctg aaatatattg ctaccattgt ataactaata acagattgct taagctgttc     2580

ccatgcacca cctgtttgct tgctttcaat gaacctttca taaattcgca gtctcagctt     2640

atggtttatg gcctcgattc tgcaaaccta acagggtcac atatgttctc taatgcagtc     2700

cttctacctg gtgtttactt ttgttaccta aataatgagt aggatcttgt tttgttttat     2760

caccagcaca cagattgcta taaactgtta ctttgtgaat tacattttta tagaagatat     2820

tttcagtgtc tttacctgag ggtatgtctt tagctatgtt ttagggccat acatttactc     2880

tatcaaatga tcttttctcc atcccccagg ctgtgcttat ttctagtgcc ttgtgctcac     2940

tcctgctctc tacagagcca gcctggcctg ggcattgtaa acagcttttc ctttttctct     3000

tactgttttc tctacagtcc tttatatttc ataccatctc tgccttataa gtggtttagt     3060

gctcagttgg ctctagtaac cagaggacac agaaagtatc ttttggaaag tttagccacc     3120

tgtgctttct gactcagagt gcatgcaaca gttagatcat gcaacagtta gattatgttt     3180

agggttagga ttttcaaaga atggaggttg ctgcactcag aaaataattc agatcatgtt     3240

tatgcattat taagttgtac tgaattcttt gcagcttaat gtgatatatg actatcttga     3300

acaagagaaa aaactaggag atgtttctcc tgaagagctt ttggggttgg gaactattct     3360

tttttaattg ctgtactact taacattgtt ctaattcagt agcttgagga acaggaacat     3420

tgttttctag agcaagataa taaaggagat gggccataca aatgttttct actttcgttg     3480

tgacaacatt gattaggtgt tgtcagtact ataaatgctt gagatataat gaatccacag     3540

cattcaaggt caggtctact caaagtctca catggaaaag tgagttctgc ctttcctttg     3600

atcgagggtc aaaatacaaa gacatttttg ctagggccta caaattgaat ttaaaaactc     3660

actgcactga ttcatctgag ctttttggtt agtattcatg gctagagtga acatagcttt     3720

agtttttgct gttgtaaaag tgttttcata agttcactca agaaaaatgc agctgttctg     3780

aactggaatt tttcagcatt ctttagaatt ttaaatgagt agagagctca acttttattc     3840

ctagcatctg cttttgactc atttctaggc agtgcttatg aagaaaaatt aaagcacaaa     3900

cattctggca ttcaatcgtt ggcagattat cttctgatga cacagaatga aagggcatct     3960

cagcctctct gaactttgta aaaatctgtc cccagttctt ccatcggtgt agttgttgca     4020

tttgagtgaa tactctcttg atttatgtat tttatgtcca gattcgccat ttctgaaatc     4080

cagatccaac acaagcagtc ttgccgttag ggcattttga agcagatagt agagtaagaa     4140

cttagtgact acagcttatt cttctgtaac atatggtttc aaacatcttt gccaaaagct     4200

aagcagtggt gaactgaaaa gggcatattg ccccaaggtt acactgaagc agctcatagc     4260

aagttaaaat attgtgacag atttgaaatc atgtttgaat ttcatagtag gaccagtaca     4320

agaatgtccc tgctagtttc tgtttgatgt ttggttctgg cggctcaggc attttgggaa     4380

ctgttgcaca gggtggagtc aaaacaacct acatataaaa agagaaaaag agaaacttgt     4440

ccatttagct ttcataagaa atcccatggc aaagggtaat aaaaaggacc taatcttaaa     4500

aatacaattt ctaagcactt gtaagaaccc agtgggttgg agcctcccac tttgtccctc     4560

ctttgaagtg gatgggaact caaggtgcaa agaacctgtt ttggaagaaa gcttggggcc     4620

atttcagccc cctgtattct catgattttc tctcaggaag cacacactgt gaatggcaga     4680

cttttcattt agccccaggt gacttactaa aaatagttga aaattattca cctaagaata     4740

gaatctcagc attgtgttaa ataaaaatga aagctttaga aggcatgaga tgttcctatc     4800

ttaaataaag catgtttctt ttctatagag aaatgtatag tttgactctc cagaatgtac     4860

tatccatctt gatgagaaaa ctcttaaata gtaccaaaca ttttgaactt taaattatgt     4920

atttaaagtg agtgtttaag aaactgtagc tgcttctttt acaagtggtg cctattaaag     4980

tcagtaatgg ccattattgt tccattgtgg aaattaaatt atgtaagctt cctaatatca     5040

taaacatatt aaaattcttc taaaatattg cttttctttt aagtgacaat ttgactattc     5100

ttatgataag cacatgagag tgtcttacat tttccaaaag caggctttaa ttgcatagtt     5160

gagtctagga aaaaataatg ttaaaagtga atatgccacc ataattactt aattatgtta     5220

gtatagaaac tacagaatat ttaccctgga aagaaaatat tggaatgtta ttataaactc     5280

ttagatattt atataattca aaagaatgca tgtttcacat tgtgacagat aaagatgtat     5340

gatttctaag gctttaaaaa ttattcataa aacagtgggc aatagataaa ggaaattctg     5400

gagaaaatga aggtatttaa agggtagttt caaagctata tatattttga aggatatatt     5460

ctttatgaac aaatatattg taaaaattta tactaaggtc atctggtaac tgtgggatta     5520

atatggtcga aaacaaatgt tatggagaag ctgtcccaag caaactaaat tacctgtact     5580

tttttcccat ttcaagggaa gaggcaacca catgaagcaa tacttcttac acatgcctaa     5640

gaacgttcat tgaaaaaata aatttttaaa aggcatgtgt ttcctatgcc accaatactt     5700

ttgaaaaatt gtgaacctta cccaaaacca tttatcatgt ccattaagta tatttgggta     5760

tataattagg aagatattta catgttccat ctccacagtg gaaaaactta ttgaggctac     5820

caaagtgtgc caagaaatgt aagtccttag agtaattaga aatgctgttt tcctcaaaag     5880

catgagaaac tagcattttc atttcttatt tactcccttt ctatatcaat gcaattcaca     5940

acccaatttt aatacatccc tatatctcaa gcatttctat cttgtacttt ttcagaaaat     6000

aaaccaaaaa taatcctttg gtctctctat cttctgacct ttgtaagcaa cagaaatgta     6060

aaaacagaag gggtccaatt tttacacgtt tttttctcaa gtagcctttc tggggatttt     6120

tattttctta atgaagtgcc aatcagcttt tcaaaatgtt ttctatttct cagcatttcc     6180

aggaagtgat aacgtttagc taaatgagta gaagtggact tccttcaaca tattgttacc     6240

ttgtctagcc ttaggaagaa aacaagagcc acctgaaaat aaatacaggc tcttttcgag     6300

catctgctga aatactgtta cagcaatttg aagttgatgt ggtaggaaag gaaggtgact     6360

tttcttgcaa aagtctttct aaacattcac actgtcctaa gagatgagct ttcttgtttt     6420

attccggtat attccacaag gtggcacttt tagagaaaaa caaatctgat gaagactaaa     6480

gaggtacttc taaaagagat ttcattctaa ctttattttt ctgcgcatat ttaactcttt     6540

cctagcactt gttttttggg atgattaata gtctctataa tgttctgtaa cttcaatatt     6600

ttacttgtta cctaggttct gaacaattgt ctgcaaataa attgttctta aggatggata     6660

atacacccat tttgatcatt taagtaaaga aagcctagtc attcattcag tcaagaaaaa     6720

atttttgaag tacccagtta ccttactttt ctagattaaa acaggcttag ttactaaaaa     6780

ggcagtcctc atctgtgaac aggatagttt cgttagaagt ataaaactcc tttagtggcc     6840

ccagttaaaa cacacatacc ctctctgctg ctttcaaatt ccctagcatg gtggcctttc     6900

aacattgatt aaattttaaa atcctaattt aaagatcagg tgagcaaaat gagtagcaca     6960

tcagtaattc agtagacaaa acttttgtct gaaaaattgc tgtattgaaa cagagcccta     7020

aaataccaaa agaccaggta attttaacat ttgtggaatc acaaatgtaa attcataaga     7080

agctctaatt aaaaaaaaaa agtctgaagt atatgagcat aacaacttag gagtgtgtct     7140

acatacttaa cttttgaagt tttttggcaa ctttatatac tttttttaaa tttacaagtc     7200

tacttaaaga cttcttatac cccaaatgat taagttaatt ttagaggtca cctttctcac     7260

agcagtgtca cttgaaattt agtagggaag gatattgcag tatttttcag tttccttagc     7320

acagcaccac agaaagcagc ttattccttt tgagtggcag acactcgacg gtgcctgccc     7380

aactttcctc ctgagtggca agcagatgag tctcagtaat tcatactgaa ccaaaatgcc     7440

acatacacta ggggcagtca gaaactggct gagaaatccc ccgcctcatt cgcccctctg     7500

ctcccaggaa ctagagtcca gttaaagccc ctatgcgaaa ggccgaattc caccccaggg     7560

tttgttataa cagtggccag tctgaacccc atttgctcgt gctcaaaact tgattcccac     7620

ttgaaagcct tccgggcgcg ctgcctcgtt gccccgcccc tttggcagga gagaggcagt     7680

gggcgaggcc gggctggggc cccgcctccc actcacctgc cggtgcctga aattatgtgc     7740

ggccccgcgg gctgctttcc gaggtcagag tgccctgctg ctgtctcaga ggcatctgtt     7800

ctgcaaatct taggaagaaa aatgtcccta gtagcaaacg ggtgtcttct gtgcataaat     7860

aagtacaaca caattctccg aaagttcggg taaaaagaga tgcggtagca gctgccctgt     7920

gtgaagctgt ctaccccgca tctctcaggc gctaagctca gtttttgttt ttgtttttgt     7980

ttttttaaag aaaagatgta taattgcagg aatttttttt tattttttta ttttccatca     8040

ttctatatat gtgatggtga aagatatgcc tggaaaagtt ttgttttgaa aagtttattt     8100

tctgcttcgt cttcagttgg caaaagctct caattcttta gcttccagtt tcttttctct     8160

ctttttcttt gttaggtaat taaaggtatg taaacaaatt atctcatgta gcaggggatt     8220

ttcatgttga gaggaatctt ccgtgtgagt tgtttggtca cacaaataac cctttctcaa     8280

ttttaggagt ttggattgtc aaatgtaggt ttttctcaaa gggggcatat aactacatat     8340

tgactgccaa gaactatgac tgtagcacta atcagcacac atagagccac acaattattt     8400

aatttctaac tctctgtggt ccctagaaaa attccgttga tgtgcttagg ttaaagttct     8460

gaagataccc gttgtaccct tacttgaaag tttctaatct taagttttat gaaatgcaat     8520

aatatgtatc agctagcaat atttctgtga tcaccaacaa ctctcagttt gatcttaaag     8580

tctgaataat aaaacaaatc ccagcagtaa tacatttctt aaacctcaca gtgcatgata     8640

tatcttttca ttctgatcct gtgtttgcaa aaatatacac atgtatatca tagttcctca     8700

ctttttattc atttgttttc ctattacctg tagtaaatat attagttagt acatggaatt     8760

tatagcatca gctaccccca ggaacagcac ctgacaggcg ggggattttt tttcaagttg     8820

ttctacattt gcataaatta tttctattat tattcatgta tgttatttat ttctgaatca     8880

cactagtcct gtgaaagtac aactgaaggc agaaagtgtt aggattttgc atctaatgtt     8940

cattatcatg gtattgatgg acctaagaaa ataaaaatta gactaagccc ccaaataagc     9000

tgcatgcatt tgtaacatga ttagtagatt tgaatatata gatgtagtat tttgggtatc     9060

taggtgtttt atcattatgt aaaggaatta aagtaaagga ctttgtagtt gtttttatta     9120

aatatgcata tagtagagtg caaaaatata gcaaaaataa aaactaaagg tagaaaagca     9180

ttttagatat gccttaattt agaaactgtg ccaggtggcc ctcggaatag atgccaggca     9240

gagaccagtg cctgggtggt gcctcctctt gtctgccctc atgaagaagc ttccctcacg     9300

tgatgtagtg ccctcgtagg tgtcatgtgg agtagtggga acaggcagta ctgttgagag     9360

gagagcagtg tgagagtttt tctgtagaag cagaactgtc agcttgtgcc ttgaggcttc     9420

cagaacgtgt cagatggaga agtccaagtt tccatgcttc aggcaactta gctgtgtaca     9480

gaagcaatcc agtgtggtaa taaaaagcaa ggattgcctg tataatttat tataaaataa     9540

aagggatttt aacaaccaac aattcccaac acctcaaaag cttgttgcat tttttggtat     9600

ttgaggtttt tatctgaagg ttaaagggca agtgtttggt atagaagagc agtatgtgtt     9660

aagaaaagaa aaatattggt tcacgtagag tgcaaattag aactagaaag ttttatacga     9720

ttatcatttt gagatgtgtt aaagtaggtt ttcactgtaa aatgtattag tgtttctgca     9780

ttgccatagg gcctggttaa aactttctct taggtttcag gaagactgtc acatacagta     9840

agcttttttc cttctgactt ataatagaaa atgttttgaa agtaaaaaaa aaaaatctaa     9900

tttggaaatt tgacttgtta gtttctgtgt ttgaaatcat ggttctagaa atgtagaaat     9960

tgtgtatatc agatactcat ctaggctgtg tgaaccagcc caagatgacc aacatcccca    10020

cacctctaca tctctgtccc ctgtatctct tcctttctac cactaaagtg ttccctgcta    10080

ccatcctggc ttgtccacat ggtgctctcc atcttcctcc acatcatgga ccacaggtgt    10140

gcctgtctag gcctggccac cactcccaac ttgacctagc cacattcatc tagagatggt    10200

tcctgatgct gggcacagac tgtgctcatg gcacccatta gaaatgcctc tagcatcttt    10260

gtatgcatct tgatttttaa accaagtcat tgtacagagc attcagtttt ggctgtggta    10320

ccaagagaaa aactaatcaa gaatataaac cacattccag gctgctgttt tctctccatc    10380

tacaggccac acttttactg tatttcttca tacttgaaat tcattctgct attttcatat    10440

cagggtacag acttataagg gtgcatgttc cttaaaggtg cataattatt cttattccgt    10500

ttgcttatat tgctacagaa tgctctgttt tggtgctttg agttctgcag acccaagaag    10560

cagtgtggaa attcactgcc tgggacacag tcttataaga atgttggcag gtgactttgt    10620

atcagatgtt gcttctcttt tctctgtaca cagattgaga gttaccacag tggcctgtcg    10680

ggtccaccct gtgggtgcag cacagctctc tgaaagcaag aaccttccta cctattctaa    10740

cgtttttgcc ctctaagaaa aatggcctca ggtatggtat agacatagca agaggggaag    10800

ggctgtctca ctctagcaac catccctcca ttacacacag aaagccctct tgaagcaaaa    10860

gaagaagaaa gaaagaaagc ttatctctaa ggctactgtc ttcagaatgc tctgagctga    10920

atgctcttgc tcctttccca agaggcagat gaaaatatag ccagtttatc tatacccttc    10980

ctatctgagg aggagaatag aaaagtaggg taaatatgta acgtaaaata tgtcattcaa    11040

ggaccaccaa aactttaagt accctatcat taaaaatctg gttttaaaag tagctcaagt    11100

aagggatgct ttgtgaccca gggtttctga agtcagatag ccattcttac ctgcccctta    11160

ctctgactta ttgggaaagg gagaactgca gtggtgtttc tgttgcagtg gcaaaggtaa    11220

catgtcagaa aattcagagg gttgcatacc aataatcctt tggaaactgg atgtcttact    11280

gggtgctaga atgaaaatgt aggtatttat tgtcagatga tgaagttcat tgtttttttc    11340

aaaattggtg ttgaaatatc actgtccaat gtgttcactt atgtgaaagc taaattgaat    11400

gaggcaaaaa gagcaaatag tttgtatatt tgtaatacct tttgtatttc ttacaataaa    11460

aatattggta gcaaataaaa ataataaaaa caataacttt aaactgcttt ctggagatga    11520

attactctcc tggctatttt cttttttact ttaatgtaaa atgagtataa ctgtagtgag    11580

taaaattcat taaattccaa gttttagcag aaaaaaaaaa aaaaaaaa                 11628


<210>  206
<211>  326
<212>  PRT
<213>  homo sapiens

<400>  206

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  207
<211>  6506
<212>  DNA
<213>  homo sapiens

<400>  207
agacgcgcct ccaccgccgg gcagtgggca ggtatggctg agggcgtgtg agcgccgagc       60

gctaagggcc gccgccacca tgccaggggg cgcaggcgcc gcccggctct gcttgctggc      120

gtttgccctg cagcccctcc ggccgcgggc ggcgcgggag cctggatgga caagaggaag      180

tgaggaaggc agccccaagc tgcagcatga acttatcata cctcagtgga agacttcaga      240

aagccccgtg agagaaaagc atccactcaa agctgagctc agggtaatgg ctgaggggcg      300

agaactgatc ctggacctgg agaagaatga gcaacttttt gctccttcct acacagaaac      360

ccattatact tcaagtggta accctcaaac caccacacgg aaattggagg atcactgctt      420

ttaccacggc acggtgaggg agacagaact gtccagcgtc acgctcagca cttgccgagg      480

aattagagga ctgattacgg tgagcagcaa cctcagctac gtcatcgagc ccctccctga      540

cagcaagggc caacacctta tttacagatc tgaacatctc aagccgcccc cgggaaactg      600

tgggttcgag cactccaagc ccaccaccag ggactgggct cttcagttta cacaacagac      660

caagaagcga cctcgcagga tgaaaaggga agatttaaac tccatgaagt atgtggagct      720

ttacctcgtg gctgattatt tagagtttca gaagaatcga cgagaccagg acgccaccaa      780

acacaagctc atagagatcg ccaactatgt tgataagttt taccgatcct tgaacatccg      840

gattgctctc gtgggcttgg aagtgtggac ccacgggaac atgtgtgaag tttcagagaa      900

tccatattct accctctggt cctttctcag ttggaggcgc aagctgcttg cccagaagta      960

ccatgacaac gcccaattaa tcacgggcat gtccttccac ggcaccacca tcggcctggc     1020

ccccctcatg gccatgtgct ctgtgtacca gtctggagga gtcaacatgg accactccga     1080

gaatgccatt ggcgtggctg ccaccatggc ccacgagatg ggccacaact ttggcatgac     1140

ccatgattct gcagattgct gctcggccag tgcggctgat ggtgggtgca tcatggcagc     1200

tgccactggg cacccctttc ccaaagtgtt caatggatgc aacaggaggg agctggacag     1260

gtatctgcag tcaggtggtg gaatgtgtct ctccaacatg ccagacacca ggatgttgta     1320

tggaggccgg aggtgtggga acgggtatct ggaagatggg gaagagtgtg actgtggaga     1380

agaagaggaa tgtaacaacc cctgctgcaa tgcctctaat tgtaccctga ggccgggggc     1440

ggagtgtgct cacggctcct gctgccacca gtgtaagctg ttggctcctg ggaccctgtg     1500

ccgcgagcag gccaggcagt gtgacctccc ggagttctgt acgggcaagt ctccccactg     1560

ccctaccaac ttctaccaga tggatggtac cccctgtgag ggcggccagg cctactgcta     1620

caacggcatg tgcctcacct accaggagca gtgccagcag ctgtggggac ccggagcccg     1680

acctgcccct gacctctgct tcgagaaggt gaatgtggca ggagacacct ttggaaactg     1740

tggaaaggac atgaatggtg aacacaggaa gtgcaacatg agagatgcga agtgtgggaa     1800

gatccagtgt cagagctctg aggcccggcc cctggagtcc aacgcggtgc ccattgacac     1860

cactatcatc atgaatggga ggcagatcca gtgccggggc acccacgtct accgaggtcc     1920

tgaggaggag ggtgacatgc tggacccagg gctggtgatg actggaacca agtgtggcta     1980

caaccatatt tgctttgagg ggcagtgcag gaacacctcc ttctttgaaa ctgaaggctg     2040

tgggaagaag tgcaatggcc atggggtctg taacaacaac cagaactgcc actgcctgcc     2100

gggctgggcc ccgcccttct gcaacacacc gggccacggg ggcagtatcg acagtgggcc     2160

tatgccccct gagagtgtgg gtcctgtggt agctggagtg ttggtggcca tcttggtgct     2220

ggcggtcctc atgctgatgt actactgctg cagacagaac aacaaactag gccaactcaa     2280

gccctcagct ctcccttcca agctgaggca acagttcagt tgtcccttca gggtttctca     2340

gaacagcggg actggtcatg ccaacccaac tttcaagctg cagacgcccc agggcaagcg     2400

aaaggtgatc aacactccgg aaatcctgcg gaagccctcc cagcctcctc cccggccccc     2460

tccagattat ctgcgtggtg ggtccccacc tgcaccactg ccagctcacc tgagcagggc     2520

tgctaggaac tccccagggc ccgggtctca aatagagagg acggagtcgt ccaggaggcc     2580

tcctccaagc cggccaattc cccccgcacc aaattgcatc gtttcccagg acttctccag     2640

gcctcggccg ccccagaagg cactcccggc aaacccagtg ccaggccgca ggagcctccc     2700

caggccagga ggtgcatccc cactgcggcc ccctggtgct ggccctcagc agtcccggcc     2760

tctggcagca cttgccccaa agtttccaga atacagatca cagagggctg gagggatgat     2820

tagctcgaaa atctagacct gtccaagggg cttctccctt tccttgagct ctctggacac     2880

tgcagaggac ccatggccat ggaaccctga agaagcatgt ctggccgcct ctgagctcct     2940

cccaccctcc tccaggaacc tccacatctc caaaaatctc cctgttgact cagtgcctcc     3000

tcggcttcct tggaagccca gagggactat gatctgatgg cctctaggtg ttgttttgtg     3060

caatatacag ccccaggtag ggaggggaga gtatgaggag ggtgactggc agcttctcct     3120

ccagactcct agccccgagg tgctgatgga gatgctcaag gccagcaagc ccctcaggcc     3180

agcacttcgc ttgcagaagc catccattca ctcctggggt gcagggcacg caagagagct     3240

tcccattgct tctgctctcc tcagaggtcc cgggctggat ggaggctggt acttacccac     3300

cccttttagc ttttagggat taaggaaggg tcaagccagc cactgctgtg gccctgccca     3360

gggcttggtt gagggaacgg cttctggctg tatggctgca tgtgacaagc cacgtcccct     3420

cccacctctc cccaaacccc tgcatccctg tattcacacg ggtcactctg actcagacag     3480

gtactattcg taggcagtgt agacagcagg aggagcaccg ggcttgggct tcctctgagc     3540

cgtgatgcca aaggttgcga ctcctgactc tggataattt ttagttgctc tttgttttct     3600

ctgccgcact ttcctggtgc cccacgcttt tctctcttcc ttcccctctc attctccctc     3660

taatgtgtgg tgctttggtg agcaaaccct cagcagtcct gaccttcggg tgaccaggtg     3720

cttgtgacct acaagtcaga gtcctctctc acagtcggcc actggatttc cctcactggc     3780

tctcaggagt gtgaccagag tagacttggg gcatggccat tggggtcata tgtttatttt     3840

tcattgtgtt ttgtgacctc agcagggtgg gggtcttcct ccttactcta agctaaatct     3900

aggtgaggtt tccccttagg gagcccagct atttacaaag tacacacgag ggagcaggct     3960

ggtcattgac ttcgggctgg accgttgccc tctgagcaga gaacagaccc atttctggga     4020

gctgcccgag atcactggag aaggcagcca gcagcagctg cactggaaca gtcagagcag     4080

ggagcctctt cctcaaccca gctttttgtc attcacttcc ttttgttctc tctctggtca     4140

ctgcccttac ctgaccctca cagaaagaga gctctgagca ggtgaggggg tctgcggtgg     4200

ctcctgtctt ccctgcagca gggaaggagg gccgtgtggt gctttgctag ataggacggt     4260

ttttgcaaag cacctggaga tgtttgctgg gagatagact cccactccac aaaggtgctg     4320

ggtggctctc cggacaggag ctggcctgac tctcactcct ctgaggcttt cctggggcct     4380

cctcccatcc tgccatgagc aattgtttgc tcttgaaaac ctcactgcaa ggctgaggct     4440

gagcttctga ttcaccaccc cagggcctcc ttatagttct ctgcacacaa taggtgcttc     4500

ttggatgttc ttgggtttgg aaataagtgg aaaatacggg atgtacccct gggggaaaag     4560

cctgggttgg gtttagaaag atctcaggaa aatgagtttc tcttccctca gggtggctgt     4620

gatacaggtt ccccatgtcc ttgccgtggg tcatccttgc tgtgggtcat ccttgctgtg     4680

gagatccatt ccccaccttt cctgtggccc aaccttttat ttaaatgtgc taccctctgc     4740

ctcaaggctt ggttcctgga aagtaaaggt gaaaacatcc cctttcaccc ctctgcaaaa     4800

caaacaagca acatcctcaa aacccaaccc catgcctcac agagcttcct gtggcttctc     4860

cagcctttct ccctcacatc aggaggtaga tagctctgaa atgacagcgc cacagccata     4920

gtgactgcat gagccatctg aacctgcagt ccaccctccc tggaaccaca ccagaaagag     4980

acctgggttg tcgttttctt gctttttgtt ttgttttgtt ttattatttt catatcacct     5040

ccatcccata aagttgtact gtgaactgga agatggtgga atgttttgga atttgataga     5100

ctttcggcaa ccagttctac taatgcttca ctcctggctc tgttcaggga ggctgcccag     5160

gaggaagact ggccattatg catccccttt tctttccagt gcccagtatg ctgttttgag     5220

gtgtcaaata caaataaatc tgggcttagg gaaggagaga ccttattcca aagcacgatt     5280

gcagaagggg aaagggaata ttgcaaaagg gagaggaagg ggccttatgg gaatagtgaa     5340

aaggctcaga ccgaccgatg gcaagatctg caagcgtctc aaagcccagg cagaaaagga     5400

cttttctttt attggaagaa gtaaacatgg ctagaaagaa ccacgttcag ggaatgacgt     5460

tgtgcccagc cttttttttt tttttttttt ttttgtctcc aggggagggg ctgtttgctg     5520

gctcaggctg aggatggccc aaagtccagg gtctggtggg gaggagggaa gcttaactca     5580

agtttgggtt agtgagttag caagctcttt gtgcagatgg ggatgtaggt aaatcttttt     5640

aaaagtgaaa ttaacctcct gccaatttta caacccaaga attttttttt aagggccttg     5700

gagccatctc taaaacaaac ctcaagggat ttagtgccct gtctccctgt ctctagaagc     5760

cttagcctgg gcacctggct caatcttgta actgcctgct agccatagat tcctttcagc     5820

cttgctgact tctccctata aaagtaaagc ctttttctgc cccagctctg agacacttgc     5880

agatcttaag gtctgagact tgctgatttt ctggttggag tgtttttttg tattgccata     5940

gtcccttccc cctgaagcaa tagcccctcc ccacctcctg caatacgcct ttccaatctt     6000

tattggaagt ctctccctgc ctacttccta atttattctt atttgacaga gggtatggaa     6060

gacttgcaat ttgaaaactg gggaccagtt ccaaagtcag taattgtgtt aaccacgtgt     6120

ataacagctc tgctggacac ccaagaaagc catgggaacg ccaactggaa aggtcccctt     6180

ccccagggga gcctgcgaag gagaggttct gtagaatcca agcccacatt tccaaagtca     6240

cccccaacgc gtcctctcac accgtccact gtgcgtttgt atgtgtctgg gatccagggc     6300

aatgtgaatt ttctttttat ttgggagatt gttcacggaa aacagatctt cttctctctt     6360

gtccacctat taattgttta caatatttgt acatctatgc aaaatacttg aatgggccat     6420

ggtgcctttt ttccttgtta gtatttaatt aaaaatgaat tgtttgtcat ttgcaatgtt     6480

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          6506


<210>  208
<211>  918
<212>  PRT
<213>  homo sapiens

<400>  208

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  209
<211>  1311
<212>  DNA
<213>  homo sapiens

<400>  209
agtctagctg ctgcacaggc tggctggctg gctggctgct aagggctgct ccacgctttt       60

gccggaggac agagactgac atggaacagg ggaagggcct ggctgtcctc atcctggcta      120

tcattcttct tcaaggtact ttggcccagt caatcaaagg aaaccacttg gttaaggtgt      180

atgactatca agaagatggt tcggtacttc tgacttgtga tgcagaagcc aaaaatatca      240

catggtttaa agatgggaag atgatcggct tcctaactga agataaaaaa aaatggaatc      300

tgggaagtaa tgccaaggac cctcgaggga tgtatcagtg taaaggatca cagaacaagt      360

caaaaccact ccaagtgtat tacagaatgt gtcagaactg cattgaacta aatgcagcca      420

ccatatctgg ctttctcttt gctgaaatcg tcagcatttt cgtccttgct gttggggtct      480

acttcattgc tggacaggat ggagttcgcc agtcgagagc ttcagacaag cagactctgt      540

tgcccaatga ccagctctac cagcccctca aggatcgaga agatgaccag tacagccacc      600

ttcaaggaaa ccagttgagg aggaattgaa ctcaggactc agagtagtcc aggtgttctc      660

ctcctattca gttcccagaa tcaaagcaat gcattttgga aagctcctag cagagagact      720

ttcagcccta aatctagact caaggttccc agagatgaca aatggagaag aaaggccatc      780

agagcaaatt tgggggtttc tcaaataaaa taaaaataaa aacaaatact gtgtttcaga      840

agcgccacct attggggaaa attgtaaaag aaaaatgaaa agatcaaata accccctgga      900

tttgaatata attttttgtg ttgtaatttt tatttcgttt ttgtataggt tataattcac      960

atggctcaaa tattcagtga aagctctccc tccaccgcca tcccctgcta cccagtgacc     1020

ctgttgccct cttcagagac aaattagttt ctcttttttt tttttttttt tttttttttg     1080

agacagtctg gctctgtcac ccaggctgaa atgcagtggc accatctcgg ctcactgcaa     1140

cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgggcag ctgggattac     1200

aggcacacac taccacacct ggctaatttt tgtattttta gtagagacag ggttttgctc     1260

tgttggccaa gctggtctcg aactcctgac ctcaagtgat ccgcccgcct c              1311


<210>  210
<211>  182
<212>  PRT
<213>  homo sapiens

<400>  210

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  211
<211>  2161
<212>  DNA
<213>  homo sapiens

<400>  211
atctttgctg caaaggctgg gtatcggctg tgctcagcaa agcgtcaact cgtgcaagaa       60

cttagcagga atagttctgg ctaaggttag gaggctgcca ccaaagtctc ttttttgttc      120

ctctgcttct cccgtttgcc tccttatcat gagatctttt tgctaagctg gcagaaagat      180

tgcatagtca gtgcttccag ctctgctccc acctgatcct gcactgtcct ctggtccctg      240

aatgaatgaa ctctgatacc caatcttgtc tcgagccttc tctatgccac tcatggctcc      300

tcttctgctc tttccatctt tttgctgaga gttctgagct ctgtacttcc tcttggccca      360

tctcacttcc tgaaacaccc ctgaagaggg ttgcttatct tgatggaact caaaaagcca      420

aaaagctgca ggcagaggcg ttgaggacat ctgtttgggg aactaagagc agcagcactt      480

tcagattcag tccatataga gctgtcctac agcattctgg aaacttgagg atgtgcggtg      540

cataaagggg ctggaagtga cccacctgtg atgagccctt tctaaggaga agggtttcca      600

agagatcacc ccaccagaaa agggtaggaa tgagcaagtt gggaatttta gactgtcact      660

gcacatggac ctctgggaag acgtctggcg agagctaggc ccactggccc tacagacgga      720

tcttgctggc tcacctgtcc ctgtggaggt tcccctggga aggcaagatg cccaacaaca      780

gcactgctct gtcattggcc aatgttacct acatcaccat ggaaattttc attggactct      840

gcgccatagt gggcaacgtg ctggtcatct gcgtggtcaa gctgaacccc agcctgcaga      900

ccaccacctt ctatttcatt gtctctctag ccctggctga cattgctgtt ggggtgctgg      960

tcatgccttt ggccattgtt gtcagcctgg gcatcacaat ccacttctac agctgccttt     1020

ttatgacttg cctactgctt atctttaccc acgcctccat catgtccttg ctggccatcg     1080

ctgtggaccg atacttgcgg gtcaagctta ccgtcagatt cagaattcct gggctccctg     1140

ggtgcattct atcattccag ttgaaagttt gcttccttcc agtcatgtgg ctcttcattc     1200

tactctcctt ggctctcatt tcagatgcca tggtcatgga tgaaaaggtc aagagaagct     1260

ttgtgctgga cacggcttct gccatctgca actacaatgc ccactacaag aatcacccca     1320

aatactggtg ccgaggctat ttccgtgact actgcaacat catcgccttc tcccctaaca     1380

gcaccaatca tgtggccctg agggacacag ggaaccagct cattgtcact atgtcctgcc     1440

tgaccaaaga ggacacgggc tggtactggt gtggcatcca gcgggacttt gccagggatg     1500

acatggattt tacagagctg attgtaactg acgacaaagg aaccctggcc aatgactttt     1560

ggtctgggaa agacctatca ggcaacaaaa ccagaagctg caaggctccc aaagttgtcc     1620

gcaaggctga ccgctccagg acgtccattc tcatcatttg catactgatc acgggtttgg     1680

gaatcatctc tgtaatcagt catttgacca aaaggaggag aagtcaaagg aatagaaggg     1740

taggcaacac tttgaagccc ttctcgcgtg tcctgactcc aaaggaaatg gctcctactg     1800

aacagatgtg actgaagatt tttttaattt agttcataaa gtgatgctac aacagaataa     1860

tcaccatgac aactggccca cacctcagag actgattctg atctcccagg aattctgaag     1920

gaccctctat ccttgacaac aatcatttgc agccaggtag caacggcggt agtcagagga     1980

gctatgatag accacaccca agcaaggctg ccctcaaata acatctcaag atcttagttc     2040

ttatgcattc catcagtcag aagtgaagaa gaggtggaga atctggattg gggaccagga     2100

aatcacttgt attttgttag ccaataaatt cctagccagt gttgaatgaa aaaaaaaaaa     2160

a                                                                     2161


<210>  212
<211>  347
<212>  PRT
<213>  homo sapiens

<400>  212

Met Pro Asn Asn Ser Thr Ala Leu Ser Leu Ala Asn Val Thr Tyr Ile 
1               5                   10                  15      


Thr Met Glu Ile Phe Ile Gly Leu Cys Ala Ile Val Gly Asn Val Leu 
            20                  25                  30          


Val Ile Cys Val Val Lys Leu Asn Pro Ser Leu Gln Thr Thr Thr Phe 
        35                  40                  45              


Tyr Phe Ile Val Ser Leu Ala Leu Ala Asp Ile Ala Val Gly Val Leu 
    50                  55                  60                  


Val Met Pro Leu Ala Ile Val Val Ser Leu Gly Ile Thr Ile His Phe 
65                  70                  75                  80  


Tyr Ser Cys Leu Phe Met Thr Cys Leu Leu Leu Ile Phe Thr His Ala 
                85                  90                  95      


Ser Ile Met Ser Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val 
            100                 105                 110         


Lys Leu Thr Val Arg Phe Arg Ile Pro Gly Leu Pro Gly Cys Ile Leu 
        115                 120                 125             


Ser Phe Gln Leu Lys Val Cys Phe Leu Pro Val Met Trp Leu Phe Ile 
    130                 135                 140                 


Leu Leu Ser Leu Ala Leu Ile Ser Asp Ala Met Val Met Asp Glu Lys 
145                 150                 155                 160 


Val Lys Arg Ser Phe Val Leu Asp Thr Ala Ser Ala Ile Cys Asn Tyr 
                165                 170                 175     


Asn Ala His Tyr Lys Asn His Pro Lys Tyr Trp Cys Arg Gly Tyr Phe 
            180                 185                 190         


Arg Asp Tyr Cys Asn Ile Ile Ala Phe Ser Pro Asn Ser Thr Asn His 
        195                 200                 205             


Val Ala Leu Arg Asp Thr Gly Asn Gln Leu Ile Val Thr Met Ser Cys 
    210                 215                 220                 


Leu Thr Lys Glu Asp Thr Gly Trp Tyr Trp Cys Gly Ile Gln Arg Asp 
225                 230                 235                 240 


Phe Ala Arg Asp Asp Met Asp Phe Thr Glu Leu Ile Val Thr Asp Asp 
                245                 250                 255     


Lys Gly Thr Leu Ala Asn Asp Phe Trp Ser Gly Lys Asp Leu Ser Gly 
            260                 265                 270         


Asn Lys Thr Arg Ser Cys Lys Ala Pro Lys Val Val Arg Lys Ala Asp 
        275                 280                 285             


Arg Ser Arg Thr Ser Ile Leu Ile Ile Cys Ile Leu Ile Thr Gly Leu 
    290                 295                 300                 


Gly Ile Ile Ser Val Ile Ser His Leu Thr Lys Arg Arg Arg Ser Gln 
305                 310                 315                 320 


Arg Asn Arg Arg Val Gly Asn Thr Leu Lys Pro Phe Ser Arg Val Leu 
                325                 330                 335     


Thr Pro Lys Glu Met Ala Pro Thr Glu Gln Met 
            340                 345         


<210>  213
<211>  2840
<212>  DNA
<213>  homo sapiens

<400>  213
tttttcctgg cactgctgag ccacctgcag ttgcgagagc cgctgggagg gataagaggg       60

aagaggacgc ccggtgaagg ggctccagcc tggcagtttc tgcgtgttag catttctaga      120

atagagtggg tgggaactga cccaagtaaa gtcccagaga ctcgaacact gacgcacagg      180

aaagcctcaa gtgggaggag aaatgcaaat cccctactga tgatggcgtc agcggctttc      240

tcctagggac tgtgaggggc gcttctgact ttggacttga gcactgcctg ggacctgtgc      300

tgagagagcg ctagcatgtc tcagtggaat caagtccaac agttagaaat caagtttttg      360

gagcaggtgg atcaattcta tgatgacaac tttcccatgg aaattcggca tctgttggcc      420

caatggattg aaaatcaaga ctgggaggca gcttctaaca atgaaaccat ggcaacgatt      480

cttcttcaaa acttgttaat acaactggat gaacagttag gtcgtgtttc caaagagaaa      540

aacctactct tgatacacaa tctaaaaaga attaggaagg tccttcaggg aaaatttcat      600

ggaaatccaa tgcatgtagc tgtggttatt tcaaactgtt taagggaaga gaggagaata      660

ttggctgcag ccaacatgcc tgtccagggg cctctagaga aatccttaca aagttcttca      720

gtttcagaaa gacagaggaa tgtggagcac aaagtggctg ccattaaaaa cagtgtgcag      780

atgacagaac aagataccaa atacttagaa gatctgcaag acgaatttga ctacaggtat      840

aaaacaattc agacaatgga tcagagtgac aagaatagtg ccatggtgaa tcaggaagtt      900

ttgacactgc aggaaatgct taacagcctc gatttcaaga gaaaggaggc tctcagtaaa      960

atgacccaaa tcatccatga gacagacctg ttaatgaaca ccatgctcat agaagagctg     1020

caagactgga agcggcggca gcaaatcgcc tgcatcgggg gtccactcca caatgggctc     1080

gaccagcttc agaactgctt tacactattg gcagaaagtc ttttccaact gagaaggcaa     1140

ttggagaaac tagaggagca atctaccaaa atgacatatg aaggtgatcc cattccaatg     1200

caaagaactc acatgctaga aagagtcacc ttcttgatct acaacctttt caagaactca     1260

tttgtggttg agcgacagcc atgtatgcca acccaccctc agaggccgtt ggtacttaaa     1320

accctaattc agttcactgt aaaactaagg ctactaataa aattgccaga actaaactat     1380

caggtaaagg ttaaggcatc aattgacaag aatgtttcaa ctctaagcaa ccgaagattt     1440

gtactttgtg gaactaatgt caaagccatg tctattgaag aatcttccaa tgggagtctc     1500

tcagtagaat ttcgacattt gcaaccaaag gaaatgaagt ccagtgctgg aggtaaagga     1560

aatgagggct gtcacatggt gactgaagaa cttcattcca taacgtttga aacacagatc     1620

tgcctctatg gcctgaccat agatttggag accagctcat tgcctgtggt gatgatttcc     1680

aatgtcagtc agttacctaa tgcttgggca tccatcattt ggtacaacgt gtcaaccaac     1740

gattcccaga acttggtttt ctttaataat cctccacctg ccacattgag tcaactactg     1800

gaggtgatga gctggcagtt ttcatcgtac gttggtcgtg gtcttaactc agatcaactc     1860

catatgctgg cagagaagct tacagtccaa tctagctaca gtgatggtca cctcacctgg     1920

gccaagttct gcaaggaaca tttacctggt aaatcattta ccttttggac atggcttgaa     1980

gcaatattgg atctaattaa gaaacacatt cttccccttt ggattgatgg gtatgtcatg     2040

ggctttgtta gcaaagagaa ggaacggctg ttgctaaagg ataaaatgcc tggcaccttt     2100

ttattaagat tcagtgaaag ccatctcgga ggaataactt tcacctgggt ggaccattct     2160

gaaagtgggg aagtgagatt ccactctgta gaaccctaca ataaaggccg gttgtctgct     2220

ctgccattcg ctgacatcct gcgagactac aaagttatta tggctgaaaa cattcctgaa     2280

aaccctctga agtacctata tcctgacatt cccaaagaca aagccttcgg taaacactac     2340

agctctcagc cttgcgaagt ttcaagacca acagaaaggg gtgacaaagg ttatgttcct     2400

tctgttttta tccccatctc aacaatccga agtgattcaa cagagccaca ttctccatca     2460

gaccttcttc ccatgtctcc aagtgtgtat gcggtgttga gagaaaacct gagtcccaca     2520

acaattgaaa ctgcaatgaa gtctccttat tctgctgaat gacaggataa actctgacgc     2580

accaagaaag gaagcaaatg aaaaagttta aagactgttc tttgcccaat aaccacattt     2640

tatttcttca gctttgtaaa taccaggttc taggaaatgt ttgacatctg aagctctctt     2700

cacactcccg tggcactcct caattgggag tgttgtgact gaaatgcttg aaaccaaagc     2760

ttcagataaa cttgcaagat aagacaactt taagaaacca gtgttaataa caatattaac     2820

agaagaaaaa aaaaaaaaaa                                                 2840


<210>  214
<211>  748
<212>  PRT
<213>  homo sapiens

<400>  214

Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His 
            20                  25                  30          


Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn 
        35                  40                  45              


Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu 
    50                  55                  60                  


Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile 
65                  70                  75                  80  


His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly 
                85                  90                  95      


Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu 
            100                 105                 110         


Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu 
        115                 120                 125             


Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu 
    130                 135                 140                 


His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp 
145                 150                 155                 160 


Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys 
                165                 170                 175     


Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn 
            180                 185                 190         


Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys 
        195                 200                 205             


Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp 
    210                 215                 220                 


Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg 
225                 230                 235                 240 


Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp 
                245                 250                 255     


Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu 
            260                 265                 270         


Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr 
        275                 280                 285             


Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val 
    290                 295                 300                 


Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg 
305                 310                 315                 320 


Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr 
                325                 330                 335     


Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu 
            340                 345                 350         


Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser 
        355                 360                 365             


Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala 
    370                 375                 380                 


Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg 
385                 390                 395                 400 


His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn 
                405                 410                 415     


Glu Gly Cys His Met Val Thr Glu Glu Leu His Ser Ile Thr Phe Glu 
            420                 425                 430         


Thr Gln Ile Cys Leu Tyr Gly Leu Thr Ile Asp Leu Glu Thr Ser Ser 
        435                 440                 445             


Leu Pro Val Val Met Ile Ser Asn Val Ser Gln Leu Pro Asn Ala Trp 
    450                 455                 460                 


Ala Ser Ile Ile Trp Tyr Asn Val Ser Thr Asn Asp Ser Gln Asn Leu 
465                 470                 475                 480 


Val Phe Phe Asn Asn Pro Pro Pro Ala Thr Leu Ser Gln Leu Leu Glu 
                485                 490                 495     


Val Met Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser 
            500                 505                 510         


Asp Gln Leu His Met Leu Ala Glu Lys Leu Thr Val Gln Ser Ser Tyr 
        515                 520                 525             


Ser Asp Gly His Leu Thr Trp Ala Lys Phe Cys Lys Glu His Leu Pro 
    530                 535                 540                 


Gly Lys Ser Phe Thr Phe Trp Thr Trp Leu Glu Ala Ile Leu Asp Leu 
545                 550                 555                 560 


Ile Lys Lys His Ile Leu Pro Leu Trp Ile Asp Gly Tyr Val Met Gly 
                565                 570                 575     


Phe Val Ser Lys Glu Lys Glu Arg Leu Leu Leu Lys Asp Lys Met Pro 
            580                 585                 590         


Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser His Leu Gly Gly Ile Thr 
        595                 600                 605             


Phe Thr Trp Val Asp His Ser Glu Ser Gly Glu Val Arg Phe His Ser 
    610                 615                 620                 


Val Glu Pro Tyr Asn Lys Gly Arg Leu Ser Ala Leu Pro Phe Ala Asp 
625                 630                 635                 640 


Ile Leu Arg Asp Tyr Lys Val Ile Met Ala Glu Asn Ile Pro Glu Asn 
                645                 650                 655     


Pro Leu Lys Tyr Leu Tyr Pro Asp Ile Pro Lys Asp Lys Ala Phe Gly 
            660                 665                 670         


Lys His Tyr Ser Ser Gln Pro Cys Glu Val Ser Arg Pro Thr Glu Arg 
        675                 680                 685             


Gly Asp Lys Gly Tyr Val Pro Ser Val Phe Ile Pro Ile Ser Thr Ile 
    690                 695                 700                 


Arg Ser Asp Ser Thr Glu Pro His Ser Pro Ser Asp Leu Leu Pro Met 
705                 710                 715                 720 


Ser Pro Ser Val Tyr Ala Val Leu Arg Glu Asn Leu Ser Pro Thr Thr 
                725                 730                 735     


Ile Glu Thr Ala Met Lys Ser Pro Tyr Ser Ala Glu 
            740                 745             


<210>  215
<211>  2735
<212>  DNA
<213>  homo sapiens

<400>  215
agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag       60

ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag      120

cagccaaaat ggatccccag tgcactatgg gactgagtaa cattctcttt gtgatggcct      180

tcctgctctc tggtgctgct cctctgaaga ttcaagctta tttcaatgag actgcagacc      240

tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta gtattttggc      300

aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa tttgacagtg      360

ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc ctgagacttc      420

acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac aaaaagccca      480

caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct aacttcagtc      540

aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat ttgacctgct      600

catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga accaagaatt      660

caactatcga gtatgatggt attatgcaga aatctcaaga taatgtcaca gaactgtacg      720

acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg accatcttct      780

gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata gagcttgagg      840

accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta      900

tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca      960

actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag accaagaaaa     1020

gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt aaaagttcga     1080

agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa gcccatacaa     1140

gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt gatttcttcc     1200

agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc tctaagtgga     1260

atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt aattctctta     1320

ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg gctcatgacc     1380

tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt aatttcatag     1440

attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt tatctgccca     1500

gaattctaag ctggtgcccc actgaatttt gtgtacctgt gactaaacaa ctacctcctc     1560

agtctgggtg ggacttatgt atttatgacc ttatagtgtt aatatcttga aacatagaga     1620

tctatgtact gtaatagtgt gattactatg ctctagagaa aagtctaccc ctgctaagga     1680

gttctcatcc ctctgtcagg gtcagtaagg aaaacggtgg cctagggtac aggcaacaat     1740

gagcagacca acctaaattt ggggaaatta ggagaggcag agatagaacc tggagccact     1800

tctatctggg ctgttgctaa tattgaggag gcttgcccca cccaacaagc catagtggag     1860

agaactgaat aaacaggaaa atgccagagc ttgtgaaccc tgtttctctt gaagaactga     1920

ctagtgagat ggcctgggga agctgtgaaa gaaccaaaag agatcacaat actcaaaaga     1980

gagagagaga gaaaaaagag agatcttgat ccacagaaat acatgaaatg tctggtctgt     2040

ccaccccatc aacaagtctt gaaacaagca acagatggat agtctgtcca aatggacata     2100

agacagacag cagtttccct ggtggtcagg gaggggtttt ggtgataccc aagttattgg     2160

gatgtcatct tcctggaagc agagctgggg agggagagcc atcaccttga taatgggatg     2220

aatggaagga ggcttaggac tttccactcc tggctgagag aggaagagct gcaacggaat     2280

taggaagacc aagacacaga tcacccgggg cttacttagc ctacagatgt cctacgggaa     2340

cgtgggctgg cccagcatag ggctagcaaa tttgagttgg atgattgttt ttgctcaagg     2400

caaccagagg aaacttgcat acagagacag atatactggg agaaatgact ttgaaaacct     2460

ggctctaagg tgggatcact aagggatggg gcagtctctg cccaaacata aagagaactc     2520

tggggagcct gagccacaaa aatgttcctt tattttatgt aaaccctcaa gggttataga     2580

ctgccatgct agacaagctt gtccatgtaa tattcccatg tttttaccct gcccctgcct     2640

tgattagact cctagcacct ggctagtttc taacatgttt tgtgcagcac agtttttaat     2700

aaatgcttgt tacattcatt taaaaaaaaa aaaaa                                2735


<210>  216
<211>  329
<212>  PRT
<213>  homo sapiens

<400>  216

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  217
<211>  1952
<212>  DNA
<213>  homo sapiens

<400>  217
gcatttctgc attcgaagaa gaatctgaga gaaacctgac gcagggagca tgggtatctg       60

gacctcaggc actgatatct tcctaagtct ttgggagatt tacgtgtctc caagaagccc      120

cggatggatg gactttatcc agcatttggg agtttgctgt ttggttgctc ttatttcagt      180

gggcctcctg tctgtggccg cctgctggtt tctgccatca atcatagcgg ccgctgcctc      240

ctggattatc acgtgtgttc tgctgtgttg ctccaagcat gcacgatgtt ttattcttct      300

tgtctttctc tcttgtggcc tgcgtgaagg caggaatgct ttgattgcag ctggcacagg      360

gatcgtcatc ttgggacacg tagaaaatat ttttcacaac tttaaaggtc tcctagatgg      420

tatgacttgc aacctaaggg caaagagctt ttccatacat tttccacttt tgaaaaaata      480

tattgaggca attcagtgga tttatggcct tgccactcca ctaagtgtat ttgatgacct      540

tgtttcttgg aaccagaccc tggcagtctc tcttttcagt cccagccatg tcctggaggc      600

acagctaaat gacagcaaag gggaagtcct gagcgtcttg taccagatgg caacaaccac      660

agaggtgttg tcctccctgg gtcagaagct acttgccttt gcagggcttt cgctcgtcct      720

gcttggcact ggcctcttca tgaagcgatt tttgggccct tgtggttgga agtatgaaaa      780

catctacatc accagacaat ttgttcagtt tgatgaaagg gagagacatc aacagaggcc      840

ctgtgtgctc ccgctgaata aggaggaaag gaggaagtat gtcatcatcc cgactttctg      900

gccgactcct aaagaaagga aaaacctggg gctgtttttc ctccccatac ttatccatct      960

ctgcatctgg gtgctgtttg cagctgtaga ttatctgctg tatcggctca ttttctcagt     1020

gagcaagcag tttcaaagct tgccagggtt tgaggttcac ttgaaactgc acggagagaa     1080

acaaggaact caagatatta tccatgattc ttcctttaat atatctgtgt ttgaacccaa     1140

ctgtatccca aaaccaaaat tccttctatc tgagacctgg gttcctctca gtgttattct     1200

tttgatatta gtgatgctgg gactgttgtc ctctatcctt atgcaactta aaatcctggt     1260

gtcagcatct ttctacccca gcgtggagag gaagcgcatc caatatctgc atgcaaagct     1320

gcttaaaaaa agatcaaagc agccgctggg agaagtcaaa agacggctga gtctctatct     1380

tacaaagatt catttctggc ttccagtcct gaaaatgatt aggaagaagc aaatggacat     1440

ggcaagtgca gacaagtcat gagagacccc gactactcct cagccacatc gcaccaacaa     1500

ttctcttcag gtctaggatg gcagtcacta ttcatgccgg ataatagaga actatgtgac     1560

gcagtcctct caggagtctg agtttacaga gccaacttgc agcacctggt tatgcctcct     1620

ttcatctcaa agccaaagag ctgccaggta aatggttatg tggtctatgt tccaaacaaa     1680

ccacatgatc ttgcctgtgt cacaatgtaa caagactcta gctgggtccc ctggtgatga     1740

gtttcagcat agaataatgt tcaaggaaaa gaaaacgaaa acagtttaaa tctctaccac     1800

agcctcacaa gcaaatgcta aggggaacat acatgtaaaa agccagcaaa ctatcttcaa     1860

actcttccgt ccttaatgtc ttccatggct attgccccca caatggtctc ttttctccct     1920

gctcccttat taaagaactc tttctgaaac cc                                   1952


<210>  218
<211>  470
<212>  PRT
<213>  homo sapiens

<400>  218

Met Gly Ile Trp Thr Ser Gly Thr Asp Ile Phe Leu Ser Leu Trp Glu 
1               5                   10                  15      


Ile Tyr Val Ser Pro Arg Ser Pro Gly Trp Met Asp Phe Ile Gln His 
            20                  25                  30          


Leu Gly Val Cys Cys Leu Val Ala Leu Ile Ser Val Gly Leu Leu Ser 
        35                  40                  45              


Val Ala Ala Cys Trp Phe Leu Pro Ser Ile Ile Ala Ala Ala Ala Ser 
    50                  55                  60                  


Trp Ile Ile Thr Cys Val Leu Leu Cys Cys Ser Lys His Ala Arg Cys 
65                  70                  75                  80  


Phe Ile Leu Leu Val Phe Leu Ser Cys Gly Leu Arg Glu Gly Arg Asn 
                85                  90                  95      


Ala Leu Ile Ala Ala Gly Thr Gly Ile Val Ile Leu Gly His Val Glu 
            100                 105                 110         


Asn Ile Phe His Asn Phe Lys Gly Leu Leu Asp Gly Met Thr Cys Asn 
        115                 120                 125             


Leu Arg Ala Lys Ser Phe Ser Ile His Phe Pro Leu Leu Lys Lys Tyr 
    130                 135                 140                 


Ile Glu Ala Ile Gln Trp Ile Tyr Gly Leu Ala Thr Pro Leu Ser Val 
145                 150                 155                 160 


Phe Asp Asp Leu Val Ser Trp Asn Gln Thr Leu Ala Val Ser Leu Phe 
                165                 170                 175     


Ser Pro Ser His Val Leu Glu Ala Gln Leu Asn Asp Ser Lys Gly Glu 
            180                 185                 190         


Val Leu Ser Val Leu Tyr Gln Met Ala Thr Thr Thr Glu Val Leu Ser 
        195                 200                 205             


Ser Leu Gly Gln Lys Leu Leu Ala Phe Ala Gly Leu Ser Leu Val Leu 
    210                 215                 220                 


Leu Gly Thr Gly Leu Phe Met Lys Arg Phe Leu Gly Pro Cys Gly Trp 
225                 230                 235                 240 


Lys Tyr Glu Asn Ile Tyr Ile Thr Arg Gln Phe Val Gln Phe Asp Glu 
                245                 250                 255     


Arg Glu Arg His Gln Gln Arg Pro Cys Val Leu Pro Leu Asn Lys Glu 
            260                 265                 270         


Glu Arg Arg Lys Tyr Val Ile Ile Pro Thr Phe Trp Pro Thr Pro Lys 
        275                 280                 285             


Glu Arg Lys Asn Leu Gly Leu Phe Phe Leu Pro Ile Leu Ile His Leu 
    290                 295                 300                 


Cys Ile Trp Val Leu Phe Ala Ala Val Asp Tyr Leu Leu Tyr Arg Leu 
305                 310                 315                 320 


Ile Phe Ser Val Ser Lys Gln Phe Gln Ser Leu Pro Gly Phe Glu Val 
                325                 330                 335     


His Leu Lys Leu His Gly Glu Lys Gln Gly Thr Gln Asp Ile Ile His 
            340                 345                 350         


Asp Ser Ser Phe Asn Ile Ser Val Phe Glu Pro Asn Cys Ile Pro Lys 
        355                 360                 365             


Pro Lys Phe Leu Leu Ser Glu Thr Trp Val Pro Leu Ser Val Ile Leu 
    370                 375                 380                 


Leu Ile Leu Val Met Leu Gly Leu Leu Ser Ser Ile Leu Met Gln Leu 
385                 390                 395                 400 


Lys Ile Leu Val Ser Ala Ser Phe Tyr Pro Ser Val Glu Arg Lys Arg 
                405                 410                 415     


Ile Gln Tyr Leu His Ala Lys Leu Leu Lys Lys Arg Ser Lys Gln Pro 
            420                 425                 430         


Leu Gly Glu Val Lys Arg Arg Leu Ser Leu Tyr Leu Thr Lys Ile His 
        435                 440                 445             


Phe Trp Leu Pro Val Leu Lys Met Ile Arg Lys Lys Gln Met Asp Met 
    450                 455                 460                 


Ala Ser Ala Asp Lys Ser 
465                 470 


<210>  219
<211>  804
<212>  DNA
<213>  homo sapiens

<400>  219
gaaggacgca ggcagcaaag agtagtcagt cccttcttgg ctctgctgac actcgagccc       60

acattccatc acctgctccc aatcatgcag gtctccactg ctgcccttgc cgtcctcctc      120

tgcaccatgg ctctctgcaa ccaggtcctc tctgcaccac ttgctgctga cacgccgacc      180

gcctgctgct tcagctacac ctcccgacag attccacaga atttcatagc tgactacttt      240

gagacgagca gccagtgctc caagcccagt gtcatcttcc taaccaagag aggccggcag      300

gtctgtgctg accccagtga ggagtgggtc cagaaatacg tcagtgacct ggagctgagt      360

gcctgagggg tccagaagct tcgaggccca gcgacctcag tgggcccagt ggggaggagc      420

aggagcctga gccttgggaa catgcgtgtg acctctacag ctacctcttc tatggactgg      480

ttattgccaa acagccacac tgtgggactc ttcttaactt aaattttaat ttatttatac      540

tatttagttt ttataattta tttttgattt cacagtgtgt ttgtgattgt ttgctctgag      600

agttccccct gtcccctcca ccttccctca cagtgtgtct ggtgacaacc gagtggctgt      660

catcggcctg tgtaggcagt catggcacca aagccaccag actgacaaat gtgtatcaga      720

tgcttttgtt cagggctgtg atcggcctgg ggaaataata aagatgttct tttaaacggt      780

aaaaaaaaaa aaaaaaaaaa aaaa                                             804


<210>  220
<211>  93
<212>  PRT
<213>  homo sapiens

<400>  220

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  221
<211>  804
<212>  DNA
<213>  homo sapiens

<400>  221
gaaggacgca ggcagcaaag agtagtcagt cccttcttgg ctctgctgac actcgagccc       60

acattccatc acctgctccc aatcatgcag gtctccactg ctgcccttgc cgtcctcctc      120

tgcaccatgg ctctctgcaa ccaggtcctc tctgcaccac ttgctgctga cacgccgacc      180

gcctgctgct tcagctacac ctcccgacag attccacaga atttcatagc tgactacttt      240

gagacgagca gccagtgctc caagcccagt gtcatcttcc taaccaagag aggccggcag      300

gtctgtgctg accccagtga ggagtgggtc cagaaatacg tcagtgacct ggagctgagt      360

gcctgagggg tccagaagct tcgaggccca gcgacctcag tgggcccagt ggggaggagc      420

aggagcctga gccttgggaa catgcgtgtg acctctacag ctacctcttc tatggactgg      480

ttattgccaa acagccacac tgtgggactc ttcttaactt aaattttaat ttatttatac      540

tatttagttt ttataattta tttttgattt cacagtgtgt ttgtgattgt ttgctctgag      600

agttccccct gtcccctcca ccttccctca cagtgtgtct ggtgacaacc gagtggctgt      660

catcggcctg tgtaggcagt catggcacca aagccaccag actgacaaat gtgtatcaga      720

tgcttttgtt cagggctgtg atcggcctgg ggaaataata aagatgttct tttaaacggt      780

aaaaaaaaaa aaaaaaaaaa aaaa                                             804


<210>  222
<211>  93
<212>  PRT
<213>  homo sapiens

<400>  222

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  223
<211>  804
<212>  DNA
<213>  homo sapiens

<400>  223
gaaggacgca ggcagcaaag agtagtcagt cccttcttgg ctctgctgac actcgagccc       60

acattccatc acctgctccc aatcatgcag gtctccactg ctgcccttgc cgtcctcctc      120

tgcaccatgg ctctctgcaa ccaggtcctc tctgcaccac ttgctgctga cacgccgacc      180

gcctgctgct tcagctacac ctcccgacag attccacaga atttcatagc tgactacttt      240

gagacgagca gccagtgctc caagcccagt gtcatcttcc taaccaagag aggccggcag      300

gtctgtgctg accccagtga ggagtgggtc cagaaatacg tcagtgacct ggagctgagt      360

gcctgagggg tccagaagct tcgaggccca gcgacctcag tgggcccagt ggggaggagc      420

aggagcctga gccttgggaa catgcgtgtg acctctacag ctacctcttc tatggactgg      480

ttattgccaa acagccacac tgtgggactc ttcttaactt aaattttaat ttatttatac      540

tatttagttt ttataattta tttttgattt cacagtgtgt ttgtgattgt ttgctctgag      600

agttccccct gtcccctcca ccttccctca cagtgtgtct ggtgacaacc gagtggctgt      660

catcggcctg tgtaggcagt catggcacca aagccaccag actgacaaat gtgtatcaga      720

tgcttttgtt cagggctgtg atcggcctgg ggaaataata aagatgttct tttaaacggt      780

aaaaaaaaaa aaaaaaaaaa aaaa                                             804


<210>  224
<211>  93
<212>  PRT
<213>  homo sapiens

<400>  224

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  225
<211>  4131
<212>  DNA
<213>  homo sapiens

<400>  225
ggtgcgcgcc gcggcttggg ggagagttga gcgcttttcc cccctctttt tttttttttt       60

cctcttcttc ttaaacaaac cacaaacgga tgtgagggaa ggaaggtgtt tcttttactc      120

ctgagcccag acacctcact ctgttccgtc taagcttgtt ttgctgaaca ctttttttta      180

aaaaaggaaa aagaaaagga gttgcttgat gtgagagtga aatggacgta agattttatc      240

cacctccagc ccagcccgcc gctgcgcccg acgctccctg tctgggacct tctccctgcc      300

tggaccccta ctattgcaac aagtttgacg gtgagaacat gtatatgagc atgacagagc      360

cgagccagga ctatgtgcca gccagccagt cctaccctgg tccaagcctg gaaagtgaag      420

acttcaacat tccaccaatt actcctcctt ccctcccaga ccactcgctg gtgcacctga      480

atgaagttga gtctggttac cattctctgt gtcaccccat gaaccataat ggcctgctac      540

catttcatcc acaaaacatg gacctccctg aaatcacagt ctccaatatg ctgggccagg      600

atggaacact gctttctaat tccatttctg tgatgccaga tatacgaaac ccagaaggaa      660

ctcagtacag ttcccatcct cagatggcag ccatgagacc aaggggccag cctgcagaca      720

tcaggcagca gccaggaatg atgccacatg gccagctgac taccattaac cagtcacagc      780

taagtgctca acttggtttg aatatgggag gaagcaatgt tccccacaac tcaccatctc      840

cacctggaag caagtctgca actccttcac catccagttc agtgcatgaa gatgaaggcg      900

atgatacctc taagatcaat ggtggagaga agcggcctgc ctctgatatg gggaaaaaac      960

caaaaactcc caaaaagaag aagaagaagg atcccaatga gccccagaag cctgtgtctg     1020

cctatgcgtt attctttcgt gatactcagg ccgccatcaa gggccaaaat ccaaacgcta     1080

cctttggcga agtctctaaa attgtggctt caatgtggga cggtttagga gaagagcaaa     1140

aacaggtcta taaaaagaaa accgaggctg cgaagaagga gtacctgaag caactcgcag     1200

catacagagc cagccttgta tccaagagct acagtgaacc tgttgacgtg aagacatctc     1260

aacctcctca gctgatcaat tcgaagccgt cggtgttcca tgggcccagc caggcccact     1320

cggccctgta cctaagttcc cactatcacc aacaaccggg aatgaatcct cacctaactg     1380

ccatgcatcc tagtctcccc aggaacatag cccccaagcc gaataaccaa atgccagtga     1440

ctgtctctat agcaaacatg gctgtgtccc ctcctcctcc cctccagatc agcccgcctc     1500

ttcaccagca tctcaacatg cagcagcacc agccgctcac catgcagcag ccccttggga     1560

accagctccc catgcaggtc cagtctgcct tacactcacc caccatgcag caaggattta     1620

ctcttcaacc cgactatcag actattatca atcctacatc tacagctgca caagttgtca     1680

cccaggcaat ggagtatgtg cgttcggggt gcagaaatcc tcccccacaa ccggtggact     1740

ggaataacga ctactgcagt agtgggggca tgcagaggga caaagcactg taccttactt     1800

gagaatctga acacctcttc tttccactga ggaattcagg gaagtgtttt caccatggat     1860

tgctttgtac agtcaaggca gttctccatt ttattagaaa atacaagttg ctaagcactt     1920

aggaccattt gagcttgtgg gtcacccact ctggaagaaa tagtcatgct tctttattat     1980

ttttttaatc ctttatggac attgtttttc ttcttccctg aaggaaattt ggaccattca     2040

gattttatgt tggttttttg ctgtgaagtg ctgcgctcta gtaactgcct tagcaactgt     2100

agatgtctcg gataaaagtc ctggattttc cattggtttt cataatgggt gtttatatga     2160

aactactaaa gactttttaa atggcttgat gtagcagtca tagcaagttt gtaaatagca     2220

tctatgttac actctcctag agtataaaat gtgaatgttt ttgtagctaa attgtaattg     2280

aaactggctc attccagttt attgatttca caataggggt taaattggca aacattcata     2340

tttttacttc atttttaaaa caactgactg atagttctat attttcaaaa tatttgaaaa     2400

taaaaagtat tcccaagtga ttttaattta aaaacaaatt ggctttgtct cattgatcag     2460

acaaaaagaa actagtatta agggaagcgc aaacacattt attttgtact gcagaaaaat     2520

tgcttttttg tatcactttt tgtgtaatgg ttagtaaatg tcatttaagt ccttttatgt     2580

ataaaactgc caaatgctta cctggtattt tattagatgc agaaacagat tggaaacagc     2640

taaattacaa cttttacata tggctctgtc ttattgtttc ttcatactgt gtctgtattt     2700

aatctttttt tatggaacct gttgcgccta tttatgaaat aataaatata ggtgtttgta     2760

agtaaatttg ttagtatttg aaagaggttt ctttgatgtt ttaacttttg ctggcaaaaa     2820

aaaattcacg cttggtgtga atactttatt atttagtttt tacagtaaca tgaataaagc     2880

caaacctgct tttcatttag cagcaaatta aagtaaccag tccttatttc tgcatttctt     2940

tggttgatgc aaacaaaaaa ctattatatt taagaacttt atttcttcat acgacataac     3000

agaattgccc tccaagtcac acaagctcca agactaaaca aacagacagg tcctctgtct     3060

taaaaaggtt acttcttggt tctcagctgg ttctagtcaa ttctgaacca ccaccccccg     3120

ccccccgcaa aaaagtaaaa gtcaaaccaa acttcctcaa gctgcatgct tttcacaaaa     3180

tccagaaagc atttaagaat tgaactaggg gctggaagaa gtgaaaggga agcatctaaa     3240

aatgaaaggt gagtaaccag atagcaaaag aaaagggaaa gccatccaaa tttgaaagct     3300

gttgatagaa attgagattc ttgctgtctt ttgtgcctct acaagctact actcattcca     3360

gaattcctgg gtcttccaag aggattctta aggtaccaga gatttgctag ggaaccaaaa     3420

gtgcttgaga atctgcctga gggcttgcat agctttcaca ttaaaaaaag aaaaagctag     3480

cagatttact cctttttagg ggatcatatc aagaaagtta gtctggttgg aaaccaagag     3540

aatggctgat gtctctttct tggaatatgt gaaataaatt tagcagttta actaaataca     3600

aatatatgca ttgtgtaatc cactcagaat taaacagaca aaaggtatgc ttgctttgga     3660

atgattttag gcattgtaca accttgaatc acttgagcat gtaataacta ataaataatg     3720

cagatccatg tgattattaa aatgactgta gctgagagct ctaattttcc tgtcttgaaa     3780

ctgtataaga actcatgtga ttaagttcac agtttattgt ttgtctgttt agtattttag     3840

aaatatacca gcactactaa ttaactaatg tcttttattt attatattat gataaagtaa     3900

aaatttcact tgcattaagt ctaaactgag aaggtaatta ctgggaggag aatgagcagc     3960

tttgactttg acaggcggtt tgtgcaggaa agcacagtgc cgtgttgttt acagcttttc     4020

tagagcagct gtgcgaccag ggtagagagt gttgaaattc aataccaaat acagtaaaaa     4080

caaatgtaaa taaaagaaaa cacatcatca ataaaactgt tattatgcgt g              4131


<210>  226
<211>  526
<212>  PRT
<213>  homo sapiens

<400>  226

Met Asp Val Arg Phe Tyr Pro Pro Pro Ala Gln Pro Ala Ala Ala Pro 
1               5                   10                  15      


Asp Ala Pro Cys Leu Gly Pro Ser Pro Cys Leu Asp Pro Tyr Tyr Cys 
            20                  25                  30          


Asn Lys Phe Asp Gly Glu Asn Met Tyr Met Ser Met Thr Glu Pro Ser 
        35                  40                  45              


Gln Asp Tyr Val Pro Ala Ser Gln Ser Tyr Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Ser Glu Asp Phe Asn Ile Pro Pro Ile Thr Pro Pro Ser Leu Pro Asp 
65                  70                  75                  80  


His Ser Leu Val His Leu Asn Glu Val Glu Ser Gly Tyr His Ser Leu 
                85                  90                  95      


Cys His Pro Met Asn His Asn Gly Leu Leu Pro Phe His Pro Gln Asn 
            100                 105                 110         


Met Asp Leu Pro Glu Ile Thr Val Ser Asn Met Leu Gly Gln Asp Gly 
        115                 120                 125             


Thr Leu Leu Ser Asn Ser Ile Ser Val Met Pro Asp Ile Arg Asn Pro 
    130                 135                 140                 


Glu Gly Thr Gln Tyr Ser Ser His Pro Gln Met Ala Ala Met Arg Pro 
145                 150                 155                 160 


Arg Gly Gln Pro Ala Asp Ile Arg Gln Gln Pro Gly Met Met Pro His 
                165                 170                 175     


Gly Gln Leu Thr Thr Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly 
            180                 185                 190         


Leu Asn Met Gly Gly Ser Asn Val Pro His Asn Ser Pro Ser Pro Pro 
        195                 200                 205             


Gly Ser Lys Ser Ala Thr Pro Ser Pro Ser Ser Ser Val His Glu Asp 
    210                 215                 220                 


Glu Gly Asp Asp Thr Ser Lys Ile Asn Gly Gly Glu Lys Arg Pro Ala 
225                 230                 235                 240 


Ser Asp Met Gly Lys Lys Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys 
                245                 250                 255     


Asp Pro Asn Glu Pro Gln Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe 
            260                 265                 270         


Arg Asp Thr Gln Ala Ala Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe 
        275                 280                 285             


Gly Glu Val Ser Lys Ile Val Ala Ser Met Trp Asp Gly Leu Gly Glu 
    290                 295                 300                 


Glu Gln Lys Gln Val Tyr Lys Lys Lys Thr Glu Ala Ala Lys Lys Glu 
305                 310                 315                 320 


Tyr Leu Lys Gln Leu Ala Ala Tyr Arg Ala Ser Leu Val Ser Lys Ser 
                325                 330                 335     


Tyr Ser Glu Pro Val Asp Val Lys Thr Ser Gln Pro Pro Gln Leu Ile 
            340                 345                 350         


Asn Ser Lys Pro Ser Val Phe His Gly Pro Ser Gln Ala His Ser Ala 
        355                 360                 365             


Leu Tyr Leu Ser Ser His Tyr His Gln Gln Pro Gly Met Asn Pro His 
    370                 375                 380                 


Leu Thr Ala Met His Pro Ser Leu Pro Arg Asn Ile Ala Pro Lys Pro 
385                 390                 395                 400 


Asn Asn Gln Met Pro Val Thr Val Ser Ile Ala Asn Met Ala Val Ser 
                405                 410                 415     


Pro Pro Pro Pro Leu Gln Ile Ser Pro Pro Leu His Gln His Leu Asn 
            420                 425                 430         


Met Gln Gln His Gln Pro Leu Thr Met Gln Gln Pro Leu Gly Asn Gln 
        435                 440                 445             


Leu Pro Met Gln Val Gln Ser Ala Leu His Ser Pro Thr Met Gln Gln 
    450                 455                 460                 


Gly Phe Thr Leu Gln Pro Asp Tyr Gln Thr Ile Ile Asn Pro Thr Ser 
465                 470                 475                 480 


Thr Ala Ala Gln Val Val Thr Gln Ala Met Glu Tyr Val Arg Ser Gly 
                485                 490                 495     


Cys Arg Asn Pro Pro Pro Gln Pro Val Asp Trp Asn Asn Asp Tyr Cys 
            500                 505                 510         


Ser Ser Gly Gly Met Gln Arg Asp Lys Ala Leu Tyr Leu Thr 
        515                 520                 525     


<210>  227
<211>  4366
<212>  DNA
<213>  homo sapiens

<400>  227
tgcattcttt gccccaaaac tctttccttt ggttgtgcta agaggtgatg cccaaggtgc       60

accacctttc aagaactgga tcatgaacaa ctttatcctc ctggaagaac agctcatcaa      120

gaaatcccaa caaaagagaa gaacttctcc ctcgaacttt aaagtccgct tctttgtgtt      180

aaccaaagcc agcctggcat actttgaaga tcgtcatggg aagaagcgca cgctgaaggg      240

gtccattgag ctctcccgaa tcaaatgtgt tgagattgtg aaaagtgaca tcagcatccc      300

atgccactat aaatacccgt ttcaggtggt gcatgacaac tacctcctat atgtgtttgc      360

tccagatcgt gagagccggc agcgctgggt gctggccctt aaagaagaaa cgaggaataa      420

taacagtttg gtgcctaaat atcatcctaa tttctggatg gatgggaagt ggaggtgctg      480

ttctcagctg gagaagcttg caacaggctg tgcccaatat gatccaacca agaatgcttc      540

aaagaagcct cttcctccta ctcctgaaga caacaggcga ccactttggg aacctgaaga      600

aactgtggtc attgccttat atgactacca aaccaatgat cctcaggaac tcgcactgcg      660

gcgcaacgaa gagtactgcc tgctggacag ttctgagatt cactggtgga gagtccagga      720

caggaatggg catgaaggat atgtaccaag cagttatctg gtggaaaaat ctccaaataa      780

tctggaaacc tatgagtggt acaataagag tatcagccga gacaaagctg aaaaacttct      840

tttggacaca ggcaaagaag gagccttcat ggtaagggat tccaggactg caggaacata      900

caccgtgtct gttttcacca aggctgttgt aagtgagaac aatccctgta taaagcatta      960

tcacatcaag gaaacaaatg acaatcctaa gcgatactat gtggctgaaa agtatgtgtt     1020

cgattccatc cctcttctca tcaactatca ccaacataat ggaggaggcc tggtgactcg     1080

actccggtat ccagtttgtt ttgggaggca gaaagcccca gttacagcag ggctgagata     1140

cgggaaatgg gtgatcgacc cctcagagct cacttttgtg caagagattg gcagtgggca     1200

atttgggttg gtgcatctgg gctactggct caacaaggac aaggtggcta tcaaaaccat     1260

tcgggaaggg gctatgtcag aagaggactt catagaggag gctgaagtaa tgatgaaact     1320

ctctcatccc aaactggtgc agctgtatgg ggtgtgcctg gagcaggccc ccatctgcct     1380

ggtgtttgag ttcatggagc acggctgcct gtcagattat ctacgcaccc agcggggact     1440

ttttgctgca gagaccctgc tgggcatgtg tctggatgtg tgtgagggca tggcctacct     1500

ggaagaggca tgtgtcatcc acagagactt ggctgccaga aattgtttgg tgggagaaaa     1560

ccaagtcatc aaggtgtctg actttgggat gacaaggttc gttctggatg atcagtacac     1620

cagttccaca ggcaccaaat tcccggtgaa gtgggcatcc ccagaggttt tctctttcag     1680

tcgctatagc agcaagtccg atgtgtggtc atttggtgtg ctgatgtggg aagttttcag     1740

tgaaggcaaa atcccgtatg aaaaccgaag caactcagag gtggtggaag acatcagtac     1800

cggatttcgg ttgtacaagc cccggctggc ctccacacac gtctaccaga ttatgaatca     1860

ctgctggaaa gagagaccag aagatcggcc agccttctcc agactgctgc gtcaactggc     1920

tgaaattgca gaatcaggac tttagtagag actgagtacc aggccacggg ctgcagatcc     1980

tgaatggagg aaggatatgt cctcattcca tagagcatta gaagctgcca ccagcccagg     2040

accctccaga ggcagcctgg cctgtggcat cagtccctga gtcaccatgg aagcagcatc     2100

ctgaccacag ctggcagtca agccacagct ggagggtcag ccaccaagct gggagctgag     2160

ccagaacagg agtgatgtct ctgcccttcc tctagcctct tgtcacatgt ggtgcacaaa     2220

cctcaacctg acagctttca gacagcattc ttgcacttct tagcaacaga gagagacatg     2280

agtaagaccc agattgctat ttttattgtt atttttaaca tgaatctaaa gtttatggtt     2340

ccagggactt tttatttgac ccaacaacac agtatcccag gatatggagg caaggggaac     2400

aaagagcatg agtctttttc caagaaaact ggtgagttaa gtaagattag agtgagtgtg     2460

ctctgttgct gtgatgctgt cagccacagc ttcctgccgt agagaatgat agagcagctg     2520

ctcacacagg aggccggata ttctgagaag cagctttatg aggttttaca gagtatgctg     2580

ctacctctct ccttgaaggg agcatggcga gacccattgg atggattggg gtgaacagtt     2640

caggtcccat gcttggagca ttgggtatct gatgtctgca ccagaacaag agaacctctg     2700

acggtggaga accatgtggt gcaagaagag atcttaggtc tcttctttta taccaagctc     2760

atcttttata ccaagctgtg caggtgacta tgcctcctct tctgcacaga atgcttccac     2820

cagcatcctg agaagaaatg attacttctg aaaaacatcc ttttttccag cctctgggaa     2880

tcagcccccc ctctctgcac tatccgatcc tcatcaacag agggcagcat tgtgttggtc     2940

aatgttccct tggcgagcaa ttgaaacttg tttaggccct agggttgagc aattttaagg     3000

ttgagactcc aagtctccta aaattctagg agagaaataa agagtctgtt tttgctcaaa     3060

ccatcaggat ggaaacagtc aggcactgac tggggtgctt ccaagaggca tgagagtgcc     3120

tactctggct tgagcacttc tatatgcaag gtgaatatgt actgagctag gagacttccc     3180

tgcaaaatct ctgttcaccc tgggttcaca tccccatgag gtaatattat tattcccatt     3240

ttacaaataa tgtaactgag gctttaaaaa gccaagacat ctgcccaaag tgatggaact     3300

agaaagtcta gagctggtat tctagcccaa atctgtctga ccgcaataca cagattcttt     3360

attcctattc gacactggct tctactgaaa atgaaacgga ttgcagaggg aataaataca     3420

aagatggaaa gccagtaaag aagtcagtat agaaccacta gcgaatagtg ttgctctggc     3480

acagaccact gtggttgatg gcatggccct ccaacttgga ataggatttt ccttttccta     3540

ttctgtatcc ttaccttggt catgttaatg actttggagt tattcagtta atgacccttt     3600

aattctcaca accaaccagt catgttgctt gaagccattt atagacgagc ttcaaagcaa     3660

ctttaaaaga ttcttctgta gaagtatgag ttcttccttt aattatcatt ccaactttca     3720

gctgtagtct tcttgaacac ttcatgagga gggacattcc ctgatataag agaggatggt     3780

gttgcaattg gctctttcta aatcatgtga cgttttgact ggcttgagat tcagatgcat     3840

aatttttaat tataattatt gtgaagtgga gagcctcaag ataaaactct gtcattcaga     3900

agatgatttt actcagctta tccaaaatta tctctgttta ctttttagaa ttttgtacat     3960

tatcttttgg gatccttaat tagagatgat ttctggaaca ttcagtctag aaagaaaaca     4020

ttggaattga ctgatctctg tggtttggtt tagaaaattc ccctgtgcat ggtattacct     4080

ttttcaagct cagattcatc taatcctcaa ctgtacatgt gtacattctt cacctcctgg     4140

tgccctatcc cgcaaaatgg gcttcctgcc tggtttttct cttctcacat tttttaaatg     4200

gtcccctgtg tttgtagaga actcccttat acagagtttt ggttctagtt ttatttcgta     4260

gattttgcat tttgtacctt ttgagactat gtatttatat ttggatcaga tgcatattta     4320

ttaatgtaca gtcactgcta gtgttcaaaa taaaaatgtt acaaat                    4366


<210>  228
<211>  620
<212>  PRT
<213>  homo sapiens

<400>  228

Met Asn Asn Phe Ile Leu Leu Glu Glu Gln Leu Ile Lys Lys Ser Gln 
1               5                   10                  15      


Gln Lys Arg Arg Thr Ser Pro Ser Asn Phe Lys Val Arg Phe Phe Val 
            20                  25                  30          


Leu Thr Lys Ala Ser Leu Ala Tyr Phe Glu Asp Arg His Gly Lys Lys 
        35                  40                  45              


Arg Thr Leu Lys Gly Ser Ile Glu Leu Ser Arg Ile Lys Cys Val Glu 
    50                  55                  60                  


Ile Val Lys Ser Asp Ile Ser Ile Pro Cys His Tyr Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Asn Tyr Leu Leu Tyr Val Phe Ala Pro Asp Arg 
                85                  90                  95      


Glu Ser Arg Gln Arg Trp Val Leu Ala Leu Lys Glu Glu Thr Arg Asn 
            100                 105                 110         


Asn Asn Ser Leu Val Pro Lys Tyr His Pro Asn Phe Trp Met Asp Gly 
        115                 120                 125             


Lys Trp Arg Cys Cys Ser Gln Leu Glu Lys Leu Ala Thr Gly Cys Ala 
    130                 135                 140                 


Gln Tyr Asp Pro Thr Lys Asn Ala Ser Lys Lys Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Glu Asp Asn Arg Arg Pro Leu Trp Glu Pro Glu Glu Thr Val Val 
                165                 170                 175     


Ile Ala Leu Tyr Asp Tyr Gln Thr Asn Asp Pro Gln Glu Leu Ala Leu 
            180                 185                 190         


Arg Arg Asn Glu Glu Tyr Cys Leu Leu Asp Ser Ser Glu Ile His Trp 
        195                 200                 205             


Trp Arg Val Gln Asp Arg Asn Gly His Glu Gly Tyr Val Pro Ser Ser 
    210                 215                 220                 


Tyr Leu Val Glu Lys Ser Pro Asn Asn Leu Glu Thr Tyr Glu Trp Tyr 
225                 230                 235                 240 


Asn Lys Ser Ile Ser Arg Asp Lys Ala Glu Lys Leu Leu Leu Asp Thr 
                245                 250                 255     


Gly Lys Glu Gly Ala Phe Met Val Arg Asp Ser Arg Thr Ala Gly Thr 
            260                 265                 270         


Tyr Thr Val Ser Val Phe Thr Lys Ala Val Val Ser Glu Asn Asn Pro 
        275                 280                 285             


Cys Ile Lys His Tyr His Ile Lys Glu Thr Asn Asp Asn Pro Lys Arg 
    290                 295                 300                 


Tyr Tyr Val Ala Glu Lys Tyr Val Phe Asp Ser Ile Pro Leu Leu Ile 
305                 310                 315                 320 


Asn Tyr His Gln His Asn Gly Gly Gly Leu Val Thr Arg Leu Arg Tyr 
                325                 330                 335     


Pro Val Cys Phe Gly Arg Gln Lys Ala Pro Val Thr Ala Gly Leu Arg 
            340                 345                 350         


Tyr Gly Lys Trp Val Ile Asp Pro Ser Glu Leu Thr Phe Val Gln Glu 
        355                 360                 365             


Ile Gly Ser Gly Gln Phe Gly Leu Val His Leu Gly Tyr Trp Leu Asn 
    370                 375                 380                 


Lys Asp Lys Val Ala Ile Lys Thr Ile Arg Glu Gly Ala Met Ser Glu 
385                 390                 395                 400 


Glu Asp Phe Ile Glu Glu Ala Glu Val Met Met Lys Leu Ser His Pro 
                405                 410                 415     


Lys Leu Val Gln Leu Tyr Gly Val Cys Leu Glu Gln Ala Pro Ile Cys 
            420                 425                 430         


Leu Val Phe Glu Phe Met Glu His Gly Cys Leu Ser Asp Tyr Leu Arg 
        435                 440                 445             


Thr Gln Arg Gly Leu Phe Ala Ala Glu Thr Leu Leu Gly Met Cys Leu 
    450                 455                 460                 


Asp Val Cys Glu Gly Met Ala Tyr Leu Glu Glu Ala Cys Val Ile His 
465                 470                 475                 480 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Gln Val Ile 
                485                 490                 495     


Lys Val Ser Asp Phe Gly Met Thr Arg Phe Val Leu Asp Asp Gln Tyr 
            500                 505                 510         


Thr Ser Ser Thr Gly Thr Lys Phe Pro Val Lys Trp Ala Ser Pro Glu 
        515                 520                 525             


Val Phe Ser Phe Ser Arg Tyr Ser Ser Lys Ser Asp Val Trp Ser Phe 
    530                 535                 540                 


Gly Val Leu Met Trp Glu Val Phe Ser Glu Gly Lys Ile Pro Tyr Glu 
545                 550                 555                 560 


Asn Arg Ser Asn Ser Glu Val Val Glu Asp Ile Ser Thr Gly Phe Arg 
                565                 570                 575     


Leu Tyr Lys Pro Arg Leu Ala Ser Thr His Val Tyr Gln Ile Met Asn 
            580                 585                 590         


His Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Ala Phe Ser Arg Leu 
        595                 600                 605             


Leu Arg Gln Leu Ala Glu Ile Ala Glu Ser Gly Leu 
    610                 615                 620 


<210>  229
<211>  6344
<212>  DNA
<213>  homo sapiens

<400>  229
atgcattaaa ctccaggtat tttcagggag gaatcatgaa gccgctcctg ttaaatcata       60

tccattttat tacgtctctc cttgtggatt acgtagaact ttggaaaatt aaacattaga      120

catcttcata gaaaatcatg tcactgattt ttaaagccag ctcaatttaa cctgccactg      180

attccctaac cagctcttct ctgactgtat cccgagggaa aatgtattga acgcagcaga      240

aggttaaggc agaggagttc ggctagaccg ggtagcagcc aatcagatgg ggagggtcca      300

aggatctgat gcctccaggc gagcagcgcc aagctgagct ggttagtctc cttttattgt      360

ggatgaacac cacgtacatg ccgtaaatgc tccctaggct ggctgcggct acaaggcaga      420

cccgggagct gagaatagag gaatacctgc ccaagcaact cattctgcac agcagccgac      480

aagacagcga ttttcctgtg ctggaatgtg cccatccaaa gacacttgga ttggacttaa      540

tcttaaacct ctggagttca agacctttta aaaagggcta aataaacaat ctctacatgt      600

aaaaggccac tgactcctac ttcctctgta tagagcaact gttgaactca gctgcctgta      660

gggcgtgatt ctcagtcacc agactcagct tggagatctt acaatgatgg caatcaggag      720

acactgaacg gagatgctac atattcctct cttgcagcaa aaggttttag aagcgttcga      780

ccaaacctac aagataaaag atcaccaact cagagccaga taacagtgaa tggaaactca      840

ggaggtgccg tgagtcccat gagttactat cagaggccgt tttccccctc ggcatattct      900

ctcccagcct cactcaactc cagcattgtc atgcagcacg gcacatccct cgattccaca      960

gacacatatc cccagcatgc gcagtctctg gatggcacca ccagcagctc tatccccctg     1020

taccgatcct cagaggaaga gaagagagtg acagtcatca aagccccgca ttacccaggg     1080

atcgggcccg tggatgaatc cggaatcccc acagcaatta gaacgacagt cgaccggccc     1140

aaggactggt acaagacgat gtttaagcaa attcacatgg tgcacaagcc ggatgatgac     1200

acagacatgt ataatactcc ttatacatac aatgcaggtc tgtacaaccc accctacagt     1260

gctcagtcac accctgctgc aaagacccaa acctacagac ctctttccaa aagccactcc     1320

gacaacagcc ccaatgcctt taaggatgcg tcctccccag tgcctccccc acatgttcca     1380

cctccagtcc cgccgcttcg accaagagat cggtcttcaa cagaaaagca tgactgggat     1440

cctccagaca gaaaagtgga cacaagaaaa tttcggtctg agccaaggag tatttttgaa     1500

tatgaacctg gcaagtcatc aattcttcag catgaaagac cagcctcctt gtatcagtcc     1560

tctatagaca gaagcctgga aagacccatg agttctgcaa gcatggccag tgacttcagg     1620

aagcggagga agagcgagcc tgcagtgggt ccaccacggg gcttgggaga tcaaagtgcg     1680

agcaggacta gcccaggccg agtggacctc ccaggatcaa gcaccactct tacaaagtct     1740

ttcactagct cttctccttc ttccccatca agagcaaaag gtggggatga tagcaaaata     1800

tgtccatccc tttgcagtta ctcagggctc aacggcaacc cctccagtga gttagattac     1860

tgtagcactt acagacagca cttggatgtc cctcgggact caccaagagc cattagtttc     1920

aagaacggct ggcaaatggc ccggcaaaac gcagaaatct ggagcagcac ggaagaaacc     1980

gtctctccca aaatcaaatc ccggagctgt gacgatctcc taaacgacga ctgcgatagc     2040

ttcccggacc cgaaagtcaa gtcggaaagc atgggctccc tgttatgtga ggaggactcc     2100

aaggagagct gccccatggc gtgggggtcc ccctacgtcc cggaggttcg cagtaacggc     2160

agatcaagga tcagacacag gtcagcccgc aacgccccgg ggttcctgaa gatgtacaag     2220

aaaatgcacc gcatcaaccg caaggacctg atgaactccg aggtgatctg ctccgtgaag     2280

tccaggattc tgcagtacga gagcgagcag cagcacaagg acctgctgcg cgcctggagc     2340

cagtgctcca cggaggaggt gccccgggac atggtgccca cacgcatctc cgaattcgaa     2400

aagctgatcc agaagtccaa atccatgcca aatttagggg atgacatgct gtctcccgta     2460

accctagaac caccgcaaaa tggcctatgt cccaagaggc ggttttccat tgagtatttg     2520

ctggaggaag aaaatcaaag cggccccccc gctcggggcc ggcgaggctg ccagtctaac     2580

gccctggtgc ccattcacat tgaagtcacc agcgatgagc agccccgagc acacgtggag     2640

ttttccgaca gcgaccagga cggggttgtg tccgaccaca gtgactacat tcacctagag     2700

gggtcatcct tctgcagtga aagtgacttt gatcactttt ccttcacatc ctccgaaagc     2760

ttttacggat ccagccacca ccaccaccat caccaccacc accaccaccg ccacctcatc     2820

agctcctgca aaggcaggtg cccggcctcc tacactcgat ttaccacaat gttaaaacac     2880

gaaagagcca gacacgaaaa caccgaggag cccagaaggc aagaaatgga ccctggcctt     2940

tctaaacttg cttttctagt cagtcctgtg cctttccgga ggaaaaaaaa ttcggctcct     3000

aagaaacaga ctgaaaaggc aaaatgtaaa gcatctgtgt ttgaggctct ggactctgcc     3060

cttaaagaca tctgtgacca aattaaagct gaaaagaaaa gggggagctt gccggacaac     3120

agcatcctgc accgcctcat cagtgagctg ctgccagatg ttcccgagag gaactcatcc     3180

ctgagagcgc tgaggaggag ccccctgcac cagcctctcc acccactgcc tcccgatggt     3240

gctattcatt gtccacccta ccagaatgac tgcgggagaa tgccccgcag tgcctctttc     3300

caagacgtgg acacagccaa cagcagctgc caccaccaag accgtggcgg tgcactccaa     3360

gaccgtgagt cccctagaag ttactcatcc actttgactg acatggggag aagtgcacca     3420

agggaaagaa gaggaactcc agaaaaagag aaattgcctg caaaagctgt ttatgatttt     3480

aaggctcaga catctaagga gttgtcattt aagaaaggag atactgtcta catcctcagg     3540

aaaattgatc aaaattggta tgagggagaa caccacggga gagtgggcat cttcccgatc     3600

tcatacgtag agaaactcac acctcctgag aaagcacagc ctgcaagacc acctccgcca     3660

gcccagcccg gagaaatcgg agaagctata gccaaataca acttcaacgc agacacaaat     3720

gtggagctgt cactgagaaa gggagataga gttattcttc ttaaaagagt tgatcaaaac     3780

tggtatgaag gtaaaatccc aggaaccaac agacaaggca tcttccctgt ttcctatgtg     3840

gaggtcgtca agaagaacac aaaaggtgct gaggactacc ctgaccctcc aataccccac     3900

agctattcta gtgataggat tcacagcttg agctcaaata agccacagcg tcctgtgttt     3960

actcatgaaa atattcaagg tgggggggaa ccgtttcagg ctctgtataa ctatactccc     4020

aggaatgaag atgagctgga gctcagagaa agtgatgtca ttgatgtcat ggaaaagtgt     4080

gatgacggct ggtttgtggg gacctcaaga agaaccaaat tctttggtac tttccccgga     4140

aactacgtca agaggctgtg aattgcgctc cctccttctg tagaggccgc ctgccagcca     4200

tgcacctgcg tcaacgcgcc tgaaacaccc cgcgggcctc ccgttgtcat gccttacggt     4260

ttccaatgcg ccgtcaccat ctccacctgc caccaaacca ccagcagagt agccgccgct     4320

gctgtgagcc tggggacgac atggcaggct ggtccccctc cgtgaaagtg tggattccta     4380

cttcctgctc taagctttga cacgtcaaaa tgtgggatca gaaagaaaaa aatcatgata     4440

tttaaaaatg gtcaaatatt tgaggcaaaa aaaaaaaaaa aaagtgtctc caggaggctg     4500

tccagcctcg tggctccatt tcaacatctc cccccaggcg atgttctccc ccaagacgac     4560

cagaaaattg tttattgggg aatgctgtgg tttgcatttt catattcttc gcttggcagt     4620

gtgtattctt ttcacaagtt tgcctagtgt cttggtttac acaatatgac aactgtaact     4680

gtactttagc tattgtttgc ctgcacatac atgttgtaat atgcacagtg attacaacct     4740

ttaaagcaag aggaggcgag ttaatttgga tgagtgtgat tttgctgatt gaatgtgagt     4800

tttcaaatag gagtcttttt ctgcaatttg tttgcatttt ttagaagtgc aaacagtaag     4860

taaataaaag ccttcggtaa taatcatgac aatacaagag gctgagctag gctacagggg     4920

aaaactattg tgttgtaaag ttgcatcgct attttatatt aaaatgtaat gatcagcatc     4980

atgaacaatg agctcttagt gttttattta tctgaaaaaa tgtaagtaaa agcagtgtta     5040

gtgagaggtg caaagaatta ttctaacaga cacctgaaag tatctgtaag caatactagt     5100

aggtaagatt tcactgtgtg tacacataca catttgagat tgtatgagaa catataatcc     5160

atatgatatg ttgtacattt tatggaaatg taatagaatc tcacacatta ttttatagaa     5220

atagagtaca gaagcatcac aagtattaaa gttggtttta gcaaggatta ggattactac     5280

aattattttt actataataa ttatttttct tctatggaac tcagaatcct ggctacattt     5340

gaggacagga atatgttgag cctgattttc ctggtgtgtg taaaatattt cctaggaata     5400

aattaggcac tttttagaag caatgttaaa tcattcaggt tttattttct gccctgaagc     5460

agaaatttaa aaaatgatat tgggacctgg aaggtttaat atggttcaca gtgcctgaat     5520

tacacctgct ccgaaaacta gctttgtatt tcttatgact ttgcataaga actgttcatc     5580

tttggatctt gagcacctta cagataaaac tttttatggc atctctttca tggacagtga     5640

tattgatctt ttcacaatgt acgtagcctc tagaattttg tacatatgtt tgctcttttt     5700

ttgtacagac tagttgttga gaaaacaggg gcgtttccta atttggtctt tatcctgcga     5760

caacactttc agcagactag cctctcctta tctcacagat cacaagcacc cctagatagt     5820

gtgattctgt cagatagcat ttatgcaaaa atctatgaag ttaaaagatc gtagaagcca     5880

aatgaaatgt acatatctac tgactgatga caagggaatt tcattaggaa gaaggtaaag     5940

aaacatcgtt gagtagccta ccttgatttc tgtcaagttc ataaccagct tcatatttta     6000

aaggcttcag gtttgaaatt aagtcaactg catgcagctt tgctgataaa tgaataattc     6060

tctttgatgc catttatgag aaaagacttc aatatctgtt gcctgtcata tttaagaaaa     6120

attactgttt ctactctctg tatctgattt taaaagaaaa aactattcat acctggcttc     6180

caggtaattg actttgaatt cttacaagca aaggtcattg tgtttttctt gaatagacat     6240

ctaataaatt ttgcttggaa gtatacttca gtttttcttc ttgacattta tctttataaa     6300

aattgtgtat tttattccaa cttgttaaac taagagaaaa tgca                      6344


<210>  230
<211>  1100
<212>  PRT
<213>  homo sapiens

<400>  230

Met Ser Tyr Tyr Gln Arg Pro Phe Ser Pro Ser Ala Tyr Ser Leu Pro 
1               5                   10                  15      


Ala Ser Leu Asn Ser Ser Ile Val Met Gln His Gly Thr Ser Leu Asp 
            20                  25                  30          


Ser Thr Asp Thr Tyr Pro Gln His Ala Gln Ser Leu Asp Gly Thr Thr 
        35                  40                  45              


Ser Ser Ser Ile Pro Leu Tyr Arg Ser Ser Glu Glu Glu Lys Arg Val 
    50                  55                  60                  


Thr Val Ile Lys Ala Pro His Tyr Pro Gly Ile Gly Pro Val Asp Glu 
65                  70                  75                  80  


Ser Gly Ile Pro Thr Ala Ile Arg Thr Thr Val Asp Arg Pro Lys Asp 
                85                  90                  95      


Trp Tyr Lys Thr Met Phe Lys Gln Ile His Met Val His Lys Pro Asp 
            100                 105                 110         


Asp Asp Thr Asp Met Tyr Asn Thr Pro Tyr Thr Tyr Asn Ala Gly Leu 
        115                 120                 125             


Tyr Asn Pro Pro Tyr Ser Ala Gln Ser His Pro Ala Ala Lys Thr Gln 
    130                 135                 140                 


Thr Tyr Arg Pro Leu Ser Lys Ser His Ser Asp Asn Ser Pro Asn Ala 
145                 150                 155                 160 


Phe Lys Asp Ala Ser Ser Pro Val Pro Pro Pro His Val Pro Pro Pro 
                165                 170                 175     


Val Pro Pro Leu Arg Pro Arg Asp Arg Ser Ser Thr Glu Lys His Asp 
            180                 185                 190         


Trp Asp Pro Pro Asp Arg Lys Val Asp Thr Arg Lys Phe Arg Ser Glu 
        195                 200                 205             


Pro Arg Ser Ile Phe Glu Tyr Glu Pro Gly Lys Ser Ser Ile Leu Gln 
    210                 215                 220                 


His Glu Arg Pro Ala Ser Leu Tyr Gln Ser Ser Ile Asp Arg Ser Leu 
225                 230                 235                 240 


Glu Arg Pro Met Ser Ser Ala Ser Met Ala Ser Asp Phe Arg Lys Arg 
                245                 250                 255     


Arg Lys Ser Glu Pro Ala Val Gly Pro Pro Arg Gly Leu Gly Asp Gln 
            260                 265                 270         


Ser Ala Ser Arg Thr Ser Pro Gly Arg Val Asp Leu Pro Gly Ser Ser 
        275                 280                 285             


Thr Thr Leu Thr Lys Ser Phe Thr Ser Ser Ser Pro Ser Ser Pro Ser 
    290                 295                 300                 


Arg Ala Lys Gly Gly Asp Asp Ser Lys Ile Cys Pro Ser Leu Cys Ser 
305                 310                 315                 320 


Tyr Ser Gly Leu Asn Gly Asn Pro Ser Ser Glu Leu Asp Tyr Cys Ser 
                325                 330                 335     


Thr Tyr Arg Gln His Leu Asp Val Pro Arg Asp Ser Pro Arg Ala Ile 
            340                 345                 350         


Ser Phe Lys Asn Gly Trp Gln Met Ala Arg Gln Asn Ala Glu Ile Trp 
        355                 360                 365             


Ser Ser Thr Glu Glu Thr Val Ser Pro Lys Ile Lys Ser Arg Ser Cys 
    370                 375                 380                 


Asp Asp Leu Leu Asn Asp Asp Cys Asp Ser Phe Pro Asp Pro Lys Val 
385                 390                 395                 400 


Lys Ser Glu Ser Met Gly Ser Leu Leu Cys Glu Glu Asp Ser Lys Glu 
                405                 410                 415     


Ser Cys Pro Met Ala Trp Gly Ser Pro Tyr Val Pro Glu Val Arg Ser 
            420                 425                 430         


Asn Gly Arg Ser Arg Ile Arg His Arg Ser Ala Arg Asn Ala Pro Gly 
        435                 440                 445             


Phe Leu Lys Met Tyr Lys Lys Met His Arg Ile Asn Arg Lys Asp Leu 
    450                 455                 460                 


Met Asn Ser Glu Val Ile Cys Ser Val Lys Ser Arg Ile Leu Gln Tyr 
465                 470                 475                 480 


Glu Ser Glu Gln Gln His Lys Asp Leu Leu Arg Ala Trp Ser Gln Cys 
                485                 490                 495     


Ser Thr Glu Glu Val Pro Arg Asp Met Val Pro Thr Arg Ile Ser Glu 
            500                 505                 510         


Phe Glu Lys Leu Ile Gln Lys Ser Lys Ser Met Pro Asn Leu Gly Asp 
        515                 520                 525             


Asp Met Leu Ser Pro Val Thr Leu Glu Pro Pro Gln Asn Gly Leu Cys 
    530                 535                 540                 


Pro Lys Arg Arg Phe Ser Ile Glu Tyr Leu Leu Glu Glu Glu Asn Gln 
545                 550                 555                 560 


Ser Gly Pro Pro Ala Arg Gly Arg Arg Gly Cys Gln Ser Asn Ala Leu 
                565                 570                 575     


Val Pro Ile His Ile Glu Val Thr Ser Asp Glu Gln Pro Arg Ala His 
            580                 585                 590         


Val Glu Phe Ser Asp Ser Asp Gln Asp Gly Val Val Ser Asp His Ser 
        595                 600                 605             


Asp Tyr Ile His Leu Glu Gly Ser Ser Phe Cys Ser Glu Ser Asp Phe 
    610                 615                 620                 


Asp His Phe Ser Phe Thr Ser Ser Glu Ser Phe Tyr Gly Ser Ser His 
625                 630                 635                 640 


His His His His His His His His His His Arg His Leu Ile Ser Ser 
                645                 650                 655     


Cys Lys Gly Arg Cys Pro Ala Ser Tyr Thr Arg Phe Thr Thr Met Leu 
            660                 665                 670         


Lys His Glu Arg Ala Arg His Glu Asn Thr Glu Glu Pro Arg Arg Gln 
        675                 680                 685             


Glu Met Asp Pro Gly Leu Ser Lys Leu Ala Phe Leu Val Ser Pro Val 
    690                 695                 700                 


Pro Phe Arg Arg Lys Lys Asn Ser Ala Pro Lys Lys Gln Thr Glu Lys 
705                 710                 715                 720 


Ala Lys Cys Lys Ala Ser Val Phe Glu Ala Leu Asp Ser Ala Leu Lys 
                725                 730                 735     


Asp Ile Cys Asp Gln Ile Lys Ala Glu Lys Lys Arg Gly Ser Leu Pro 
            740                 745                 750         


Asp Asn Ser Ile Leu His Arg Leu Ile Ser Glu Leu Leu Pro Asp Val 
        755                 760                 765             


Pro Glu Arg Asn Ser Ser Leu Arg Ala Leu Arg Arg Ser Pro Leu His 
    770                 775                 780                 


Gln Pro Leu His Pro Leu Pro Pro Asp Gly Ala Ile His Cys Pro Pro 
785                 790                 795                 800 


Tyr Gln Asn Asp Cys Gly Arg Met Pro Arg Ser Ala Ser Phe Gln Asp 
                805                 810                 815     


Val Asp Thr Ala Asn Ser Ser Cys His His Gln Asp Arg Gly Gly Ala 
            820                 825                 830         


Leu Gln Asp Arg Glu Ser Pro Arg Ser Tyr Ser Ser Thr Leu Thr Asp 
        835                 840                 845             


Met Gly Arg Ser Ala Pro Arg Glu Arg Arg Gly Thr Pro Glu Lys Glu 
    850                 855                 860                 


Lys Leu Pro Ala Lys Ala Val Tyr Asp Phe Lys Ala Gln Thr Ser Lys 
865                 870                 875                 880 


Glu Leu Ser Phe Lys Lys Gly Asp Thr Val Tyr Ile Leu Arg Lys Ile 
                885                 890                 895     


Asp Gln Asn Trp Tyr Glu Gly Glu His His Gly Arg Val Gly Ile Phe 
            900                 905                 910         


Pro Ile Ser Tyr Val Glu Lys Leu Thr Pro Pro Glu Lys Ala Gln Pro 
        915                 920                 925             


Ala Arg Pro Pro Pro Pro Ala Gln Pro Gly Glu Ile Gly Glu Ala Ile 
    930                 935                 940                 


Ala Lys Tyr Asn Phe Asn Ala Asp Thr Asn Val Glu Leu Ser Leu Arg 
945                 950                 955                 960 


Lys Gly Asp Arg Val Ile Leu Leu Lys Arg Val Asp Gln Asn Trp Tyr 
                965                 970                 975     


Glu Gly Lys Ile Pro Gly Thr Asn Arg Gln Gly Ile Phe Pro Val Ser 
            980                 985                 990         


Tyr Val Glu Val Val Lys Lys Asn  Thr Lys Gly Ala Glu  Asp Tyr Pro 
        995                 1000                 1005             


Asp Pro  Pro Ile Pro His Ser  Tyr Ser Ser Asp Arg  Ile His Ser 
    1010                 1015                 1020             


Leu Ser  Ser Asn Lys Pro Gln  Arg Pro Val Phe Thr  His Glu Asn 
    1025                 1030                 1035             


Ile Gln  Gly Gly Gly Glu Pro  Phe Gln Ala Leu Tyr  Asn Tyr Thr 
    1040                 1045                 1050             


Pro Arg  Asn Glu Asp Glu Leu  Glu Leu Arg Glu Ser  Asp Val Ile 
    1055                 1060                 1065             


Asp Val  Met Glu Lys Cys Asp  Asp Gly Trp Phe Val  Gly Thr Ser 
    1070                 1075                 1080             


Arg Arg  Thr Lys Phe Phe Gly  Thr Phe Pro Gly Asn  Tyr Val Lys 
    1085                 1090                 1095             


Arg Leu  
    1100 


<210>  231
<211>  4356
<212>  DNA
<213>  homo sapiens

<400>  231
gccggggagg cgcgctcgct ccgcgctccc ttcgctcgct cgttccctcc tccctcggca       60

gccgcggcgg cagcaggaga aggcggcggc ggcggctagg gatcagacat ggcggcggat      120

ctgaacctgg agtggatctc cctgccccgg tcctggactt acgggatcac caggggcggc      180

cgagtcttct tcatcaacga ggaggccaag agcaccacct ggctgcaccc cgtcaccggc      240

gaggcggtgg tcaccggaca ccggcggcag agcacagatt tgcctactgg ctgggaagaa      300

gcatatactt ttgaaggtgc aagatactat ataaaccata atgaaaggaa agtgacctgc      360

aaacatccag tcacaggaca accatcacag gacaattgta tttttgtagt gaatgaacag      420

actgttgcaa ccatgacatc tgaagaaaag aaggaacggc caataagtat gataaatgaa      480

gcttctaact ataacgtgac ttcagattat gcagtgcatc caatgagccc tgtaggcaga      540

acttcacgag cttcaaaaaa agttcataat tttggaaaga ggtcaaattc aattaaaagg      600

aatcctaatg caccggttgt cagacgaggt tggctttata aacaggacag tactggcatg      660

aaattgtgga agaaacgctg gtttgtgctt tctgaccttt gcctctttta ttatagagat      720

gagaaagaag agggtatcct gggaagcata ctgttaccta gttttcagat agctttgctt      780

acctctgaag atcacattaa tcgcaaatat gcttttaagg cagcccatcc aaacatgcgg      840

acctattatt tctgcactga tacaggaaag gaaatggagt tgtggatgaa agccatgtta      900

gatgctgccc tagtacagac agaacctgtg aaaagagtgg acaagattac atctgaaaat      960

gcaccaacta aagaaaccaa taacattccc aaccatagag tgctaattaa accagagatc     1020

caaaacaatc aaaaaaacaa ggaaatgagc aaaattgaag aaaaaaaggc attagaagct     1080

gaaaaatatg gatttcagaa ggatggtcaa gatagaccct taacaaaaat taatagtgta     1140

aagctgaatt ctctgccatc tgaatatgag agtgggtcag catgccctgc tcagactgtg     1200

cactacagac caatcaactt gagcagttca gagaacaaaa tagtcaatgt tagcctggca     1260

gatcttagag gtggaaatcg ccccaataca gggcccttat acacagaggc cgatcgagtc     1320

atacagagaa caaattcaat gcagcagttg gaacagtgga ttaaaatcca gaaggggagg     1380

ggtcatgaag aagaaaccag gggagtaatt tcttaccaaa cattaccaag aaatatgcca     1440

agtcacagag cccagattat ggcccgctac cctgaaggtt atagaacact cccaagaaac     1500

agcaagacaa ggcctgaaag tatctgcagt gtaacccctt ccactcatga caagacatta     1560

ggacccggag cggaggagaa acggaggtcc atgagagatg acacaatgtg gcagctctac     1620

gaatggcagc agcgtcagtt ttataacaaa cagagcaccc tccctcgaca cagtactttg     1680

agtagtccca aaaccatggt aaatatttct gaccagacaa tgcactctat tcccacatca     1740

ccttcccacg ggtcaatagc tgcttatcag ggatactccc ctcaacgaac ttacagatcg     1800

gaagtgtctt caccaattca gagaggagat gtgacaatag accgcagaca cagggcccat     1860

caccctaagc atgtctatgt gcctgacaga aggtcagtgc cagctggcct gactttacag     1920

tctgttagtc cccagagcct ccaagggaaa acgctgtcac aagatgaagg tagaggcaca     1980

ttatacaaat acagacctga agaagtagat attgatgcca agttaagccg attatgtgaa     2040

caagataaag tggtgcatgc tctggaagag aaacttcagc aactccacaa ggagaaatac     2100

acgcttgagc aagctttgct atcagccagc caagagatag aaatgcatgc agataaccca     2160

gcagccattc agacagtggt gttacaaagg gatgatttac aaaatggact gcttagtacg     2220

tgtcgagaac tttctcgagc cactgccgaa ttggaacgag catggagaga atatgataag     2280

ttagaatacg atgtaactgt taccaggaac cagatgcaag agcagctgga tcaccttggt     2340

gaagttcaga cggaatcagc aggaattcag cgtgcacaga ttcagaaaga actttggcga     2400

attcaggatg tcatggaagg gctgagtaaa cataagcagc aaagaggtac tacagaaata     2460

ggtatgatag gatcaaagcc tttctcaaca gttaagtaca aaaatgaggg tccagattat     2520

agactctaca agagtgaacc agagttaaca acagtggcag aagttgatga atctaatgga     2580

gaagaaaaat cagaacctgt ttcagagata gaaacttcag ttgttaaagg ttcccacttt     2640

cctgttggag tagtccctcc aagagcaaaa tcaccaacac ccgaatcttc gacaatagct     2700

tcctatgtaa ccttgaggaa aactaagaag atgatggatc taagaacgga aagaccaaga     2760

agtgcagtgg aacagctctg tttggctgaa agtactcgac caaggatgac tgtggaagag     2820

caaatggaaa gaataagaag acatcaacaa gcgtgcctga gggagaagaa aaaagggtta     2880

aatgttatcg gtgcttcaga ccagtcaccc ttacaaagcc cttcaaattt aagggataat     2940

ccatttagga ctactcagac tcgaaggagg gatgataagg aactggacac tgccattaga     3000

gaaaatgatg taaagccaga ccatgaaact cctgcaacag aaattgttca actaaaagaa     3060

accgaacccc aaaatgtgga cttcagcaaa gagttaaaaa aaactgaaaa catttcatat     3120

gaaatgcttt ttgaacctga gccaaatgga gtaaattctg tggaaatgat ggataaagaa     3180

agaaacaaag acaaaatgcc tgaggatgtt acattcagcc ctcaagatga aacacagacc     3240

gcaaatcata aaccagaaga gcatcctgaa gaaaatacaa agaacagtgt tgacgaacag     3300

gaagaaactg ttatttctta cgaatcaact cctgaggttt ctagaggaaa tcaaacaatg     3360

gcagtgaaaa gtctgtcccc atctcctgag tcctcggcat cgccagttcc atccactcag     3420

ccgcagctca cagaaggatc acatttcatg tgtgtgtagt cttagaagaa ctatactgac     3480

ttctgttgaa accattcaaa gctaaagaca tggaccttca gcagtgtaag aagatattgt     3540

acagtatatt ttaaatctat gaaattcata gttctgatgc ttttggtcac agagcatcat     3600

tttatcactt ctggaaaatg tttattccaa aacagcttta atggcccata tgtacacttc     3660

gtaatctcaa ggttattatt ctgacaccag cttgctgcta tgatttcaga gcacataagt     3720

aaaggtgctt tttaatgtgc agtctatttc cagagcttac ttagttgctg atttccagat     3780

ttcgatgttt cttaagtcta ggtgaattta tatatatatt tttttgcttt tcattttcta     3840

aagttagtta ttatttccat tgaagcttgt tttctttttt ttcttcccat tttagctact     3900

gcagtgcttt tgtttcacac ttgatttgta aaaattttat atatatgtat ttaaaatgtg     3960

ccattttatt gctaagtgaa gtatgtcctg ttttctgcta taattctttc tcggtcagat     4020

tgcaatgtca gcagttactg ccacactcct gtcagcttaa acacaaatgt tactgcttat     4080

cttttcttaa aaaaaaaaaa aacaaagtgt aggtattttg aagtactggg cttatatttc     4140

attggaatac atgtgtacag caataagcag gtttccaaat ccggtactta gtttgtgtac     4200

aaatgtaatt atgttcattg tgtatatatt atacaatgag cacatgtaat gtattaaagg     4260

ctacttacta ttgtttaaat gcaaatgttc atatctcatt tcttttttta tcatgttaaa     4320

taaatgttga tgttcttaaa aaaaaaaaaa aaaaaa                               4356


<210>  232
<211>  1116
<212>  PRT
<213>  homo sapiens

<400>  232

Met Ala Ala Asp Leu Asn Leu Glu Trp Ile Ser Leu Pro Arg Ser Trp 
1               5                   10                  15      


Thr Tyr Gly Ile Thr Arg Gly Gly Arg Val Phe Phe Ile Asn Glu Glu 
            20                  25                  30          


Ala Lys Ser Thr Thr Trp Leu His Pro Val Thr Gly Glu Ala Val Val 
        35                  40                  45              


Thr Gly His Arg Arg Gln Ser Thr Asp Leu Pro Thr Gly Trp Glu Glu 
    50                  55                  60                  


Ala Tyr Thr Phe Glu Gly Ala Arg Tyr Tyr Ile Asn His Asn Glu Arg 
65                  70                  75                  80  


Lys Val Thr Cys Lys His Pro Val Thr Gly Gln Pro Ser Gln Asp Asn 
                85                  90                  95      


Cys Ile Phe Val Val Asn Glu Gln Thr Val Ala Thr Met Thr Ser Glu 
            100                 105                 110         


Glu Lys Lys Glu Arg Pro Ile Ser Met Ile Asn Glu Ala Ser Asn Tyr 
        115                 120                 125             


Asn Val Thr Ser Asp Tyr Ala Val His Pro Met Ser Pro Val Gly Arg 
    130                 135                 140                 


Thr Ser Arg Ala Ser Lys Lys Val His Asn Phe Gly Lys Arg Ser Asn 
145                 150                 155                 160 


Ser Ile Lys Arg Asn Pro Asn Ala Pro Val Val Arg Arg Gly Trp Leu 
                165                 170                 175     


Tyr Lys Gln Asp Ser Thr Gly Met Lys Leu Trp Lys Lys Arg Trp Phe 
            180                 185                 190         


Val Leu Ser Asp Leu Cys Leu Phe Tyr Tyr Arg Asp Glu Lys Glu Glu 
        195                 200                 205             


Gly Ile Leu Gly Ser Ile Leu Leu Pro Ser Phe Gln Ile Ala Leu Leu 
    210                 215                 220                 


Thr Ser Glu Asp His Ile Asn Arg Lys Tyr Ala Phe Lys Ala Ala His 
225                 230                 235                 240 


Pro Asn Met Arg Thr Tyr Tyr Phe Cys Thr Asp Thr Gly Lys Glu Met 
                245                 250                 255     


Glu Leu Trp Met Lys Ala Met Leu Asp Ala Ala Leu Val Gln Thr Glu 
            260                 265                 270         


Pro Val Lys Arg Val Asp Lys Ile Thr Ser Glu Asn Ala Pro Thr Lys 
        275                 280                 285             


Glu Thr Asn Asn Ile Pro Asn His Arg Val Leu Ile Lys Pro Glu Ile 
    290                 295                 300                 


Gln Asn Asn Gln Lys Asn Lys Glu Met Ser Lys Ile Glu Glu Lys Lys 
305                 310                 315                 320 


Ala Leu Glu Ala Glu Lys Tyr Gly Phe Gln Lys Asp Gly Gln Asp Arg 
                325                 330                 335     


Pro Leu Thr Lys Ile Asn Ser Val Lys Leu Asn Ser Leu Pro Ser Glu 
            340                 345                 350         


Tyr Glu Ser Gly Ser Ala Cys Pro Ala Gln Thr Val His Tyr Arg Pro 
        355                 360                 365             


Ile Asn Leu Ser Ser Ser Glu Asn Lys Ile Val Asn Val Ser Leu Ala 
    370                 375                 380                 


Asp Leu Arg Gly Gly Asn Arg Pro Asn Thr Gly Pro Leu Tyr Thr Glu 
385                 390                 395                 400 


Ala Asp Arg Val Ile Gln Arg Thr Asn Ser Met Gln Gln Leu Glu Gln 
                405                 410                 415     


Trp Ile Lys Ile Gln Lys Gly Arg Gly His Glu Glu Glu Thr Arg Gly 
            420                 425                 430         


Val Ile Ser Tyr Gln Thr Leu Pro Arg Asn Met Pro Ser His Arg Ala 
        435                 440                 445             


Gln Ile Met Ala Arg Tyr Pro Glu Gly Tyr Arg Thr Leu Pro Arg Asn 
    450                 455                 460                 


Ser Lys Thr Arg Pro Glu Ser Ile Cys Ser Val Thr Pro Ser Thr His 
465                 470                 475                 480 


Asp Lys Thr Leu Gly Pro Gly Ala Glu Glu Lys Arg Arg Ser Met Arg 
                485                 490                 495     


Asp Asp Thr Met Trp Gln Leu Tyr Glu Trp Gln Gln Arg Gln Phe Tyr 
            500                 505                 510         


Asn Lys Gln Ser Thr Leu Pro Arg His Ser Thr Leu Ser Ser Pro Lys 
        515                 520                 525             


Thr Met Val Asn Ile Ser Asp Gln Thr Met His Ser Ile Pro Thr Ser 
    530                 535                 540                 


Pro Ser His Gly Ser Ile Ala Ala Tyr Gln Gly Tyr Ser Pro Gln Arg 
545                 550                 555                 560 


Thr Tyr Arg Ser Glu Val Ser Ser Pro Ile Gln Arg Gly Asp Val Thr 
                565                 570                 575     


Ile Asp Arg Arg His Arg Ala His His Pro Lys His Val Tyr Val Pro 
            580                 585                 590         


Asp Arg Arg Ser Val Pro Ala Gly Leu Thr Leu Gln Ser Val Ser Pro 
        595                 600                 605             


Gln Ser Leu Gln Gly Lys Thr Leu Ser Gln Asp Glu Gly Arg Gly Thr 
    610                 615                 620                 


Leu Tyr Lys Tyr Arg Pro Glu Glu Val Asp Ile Asp Ala Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Cys Glu Gln Asp Lys Val Val His Ala Leu Glu Glu Lys Leu 
                645                 650                 655     


Gln Gln Leu His Lys Glu Lys Tyr Thr Leu Glu Gln Ala Leu Leu Ser 
            660                 665                 670         


Ala Ser Gln Glu Ile Glu Met His Ala Asp Asn Pro Ala Ala Ile Gln 
        675                 680                 685             


Thr Val Val Leu Gln Arg Asp Asp Leu Gln Asn Gly Leu Leu Ser Thr 
    690                 695                 700                 


Cys Arg Glu Leu Ser Arg Ala Thr Ala Glu Leu Glu Arg Ala Trp Arg 
705                 710                 715                 720 


Glu Tyr Asp Lys Leu Glu Tyr Asp Val Thr Val Thr Arg Asn Gln Met 
                725                 730                 735     


Gln Glu Gln Leu Asp His Leu Gly Glu Val Gln Thr Glu Ser Ala Gly 
            740                 745                 750         


Ile Gln Arg Ala Gln Ile Gln Lys Glu Leu Trp Arg Ile Gln Asp Val 
        755                 760                 765             


Met Glu Gly Leu Ser Lys His Lys Gln Gln Arg Gly Thr Thr Glu Ile 
    770                 775                 780                 


Gly Met Ile Gly Ser Lys Pro Phe Ser Thr Val Lys Tyr Lys Asn Glu 
785                 790                 795                 800 


Gly Pro Asp Tyr Arg Leu Tyr Lys Ser Glu Pro Glu Leu Thr Thr Val 
                805                 810                 815     


Ala Glu Val Asp Glu Ser Asn Gly Glu Glu Lys Ser Glu Pro Val Ser 
            820                 825                 830         


Glu Ile Glu Thr Ser Val Val Lys Gly Ser His Phe Pro Val Gly Val 
        835                 840                 845             


Val Pro Pro Arg Ala Lys Ser Pro Thr Pro Glu Ser Ser Thr Ile Ala 
    850                 855                 860                 


Ser Tyr Val Thr Leu Arg Lys Thr Lys Lys Met Met Asp Leu Arg Thr 
865                 870                 875                 880 


Glu Arg Pro Arg Ser Ala Val Glu Gln Leu Cys Leu Ala Glu Ser Thr 
                885                 890                 895     


Arg Pro Arg Met Thr Val Glu Glu Gln Met Glu Arg Ile Arg Arg His 
            900                 905                 910         


Gln Gln Ala Cys Leu Arg Glu Lys Lys Lys Gly Leu Asn Val Ile Gly 
        915                 920                 925             


Ala Ser Asp Gln Ser Pro Leu Gln Ser Pro Ser Asn Leu Arg Asp Asn 
    930                 935                 940                 


Pro Phe Arg Thr Thr Gln Thr Arg Arg Arg Asp Asp Lys Glu Leu Asp 
945                 950                 955                 960 


Thr Ala Ile Arg Glu Asn Asp Val Lys Pro Asp His Glu Thr Pro Ala 
                965                 970                 975     


Thr Glu Ile Val Gln Leu Lys Glu Thr Glu Pro Gln Asn Val Asp Phe 
            980                 985                 990         


Ser Lys Glu Leu Lys Lys Thr Glu  Asn Ile Ser Tyr Glu  Met Leu Phe 
        995                 1000                 1005             


Glu Pro  Glu Pro Asn Gly Val  Asn Ser Val Glu Met  Met Asp Lys 
    1010                 1015                 1020             


Glu Arg  Asn Lys Asp Lys Met  Pro Glu Asp Val Thr  Phe Ser Pro 
    1025                 1030                 1035             


Gln Asp  Glu Thr Gln Thr Ala  Asn His Lys Pro Glu  Glu His Pro 
    1040                 1045                 1050             


Glu Glu  Asn Thr Lys Asn Ser  Val Asp Glu Gln Glu  Glu Thr Val 
    1055                 1060                 1065             


Ile Ser  Tyr Glu Ser Thr Pro  Glu Val Ser Arg Gly  Asn Gln Thr 
    1070                 1075                 1080             


Met Ala  Val Lys Ser Leu Ser  Pro Ser Pro Glu Ser  Ser Ala Ser 
    1085                 1090                 1095             


Pro Val  Pro Ser Thr Gln Pro  Gln Leu Thr Glu Gly  Ser His Phe 
    1100                 1105                 1110             


Met Cys  Val 
    1115     


<210>  233
<211>  14773
<212>  DNA
<213>  homo sapiens

<400>  233
ctgggcggcc gggcgcgggg agagggcgcg ggagcggctc gtgcggcagg taccatgcgg       60

acgcgcgagc ccggcgaggg ccccggcagg cccggtccct gctcgggggc gcgctgagac      120

ggcgggtgag ctccacgaga gcgccgtcgc cacttcgggc caactttgcg attcccgaca      180

gttaagcaat ggggagacat ttggctttgc tcctgcttct gctccttctc ttccaacatt      240

ttggagacag tgatggcagc caacgacttg aacagactcc tctgcagttt acacacctcg      300

agtacaacgt caccgtgcag gagaactctg cagctaagac ttatgtgggg catcctgtca      360

agatgggtgt ttacattaca catccagcgt gggaagtaag gtacaaaatt gtttccggag      420

acagtgaaaa cctgttcaaa gctgaagagt acattctcgg agacttttgc tttctaagaa      480

taaggaccaa aggaggaaat acagctattc ttaatagaga agtgaaggat cactacacat      540

tgatagtgaa agcacttgaa aaaaatacta atgtggaggc gcgaacaaag gtcagggtgc      600

aggtgctgga tacaaatgac ttgagaccgt tattctcacc cacctcatac agcgtttctt      660

tacctgaaaa cacagctata aggaccagta tcgcaagagt cagcgccacg gatgcagaca      720

taggaaccaa cggggaattt tactacagtt ttaaagatcg aacagatatg tttgctattc      780

acccaaccag tggtgtgata gtgttaactg gtagacttga ttacctagag accaagctct      840

atgagatgga aatcctcgct gcggaccgtg gcatgaagtt gtatgggagc agtggcatca      900

gcagcatggc caagctaacg gtgcacatcg aacaggccaa tgaatgtgct ccggtgataa      960

cagcagtgac attgtcacca tcagaactgg acagggaccc agcatatgca attgtgacag     1020

tggatgactg cgatcagggt gccaatggtg acatagcatc tttaagcatc gtggcaggtg     1080

accttctcca gcagtttaga acagtgaggt cctttccagg gagtaaggag tataaagtca     1140

aagccatcgg tggcattgat tgggacagtc atcctttcgg ctacaatctc acactacagg     1200

ctaaagataa aggaactccg ccccagttct cttctgttaa agtcattcac gtgacttctc     1260

cacagttcaa agccgggcca gtcaagtttg aaaaggatgt ttacagagca gaaataagtg     1320

aatttgctcc tcccaacaca cctgtggtca tggtaaaggc cattcctgct tattcccatt     1380

tgaggtatgt ttttaaaagt acacctggaa aagctaaatt cagtttaaat tacaacactg     1440

gtctcatttc tattttagaa ccagttaaaa gacagcaggc agcccatttt gaacttgaag     1500

taacaacaag tgacagaaaa gcgtccacca aggtcttggt gaaagtctta ggtgcaaata     1560

gcaatccccc tgaatttacc cagacagcgt acaaagctgc ttttgatgag aacgtgccca     1620

ttggtactac tgtcatgagc ctgagtgccg tagaccctga tgagggtgag aacgggtacg     1680

tgacatacag tatcgcaaat ttaaatcatg tgccgtttgc gattgaccat ttcactggtg     1740

ccgtgagtac gtcagaaaac ctggactacg aactgatgcc tcgggtttat actctgagga     1800

ttcgtgcatc agactggggc ttgccgtacc gccgggaagt cgaagtcctt gctacaatta     1860

ctctcaataa cttgaatgac aacacacctt tgtttgagaa aataaattgt gaagggacaa     1920

ttcccagaga tctaggcgtg ggagagcaaa taaccactgt ttctgctatt gatgcagatg     1980

aacttcagtt ggtacagtat cagattgaag ctggaaatga actggatttc tttagtttaa     2040

accccaactc gggggtattg tcattaaagc gatcgctaat ggatggctta ggtgcaaagg     2100

tgtctttcca cagtctgaga atcacagcta cagatggaga aaattttgcc acaccattat     2160

atatcaacat aacagtggct gccagtcaca agctggtaaa cttgcagtgt gaagagactg     2220

gtgttgccaa aatgctggca gagaagctcc tgcaggcaaa taaattacac aaccagggag     2280

aggtggagga tattttcttc gattctcact ctgtcaatgc tcacataccg cagtttagaa     2340

gcactcttcc gactggtatt caggtaaagg aaaaccagcc tgtgggttcc agtgtaattt     2400

tcatgaactc cactgacctt gacactggct tcaatggaaa actggtctat gctgtttctg     2460

gaggaaatga ggatagttgc ttcatgattg atatggaaac aggaatgctg aaaattttat     2520

ctcctcttga ccgtgaaaca acagacaaat acaccctgaa tattaccgtc tatgaccttg     2580

ggatacccca gaaggctgcg tggcgtcttc tacatgtcgt ggttgtcgat gccaatgata     2640

atccacccga gtttttacag gagagctatt ttgtggaagt gagtgaagac aaggaggtac     2700

atagtgaaat catccaggtt gaagccacag ataaagacct ggggcccaac ggacacgtga     2760

cgtactcaat tgttacagac acagacacat tttcaattga cagcgtgacg ggtgttgtta     2820

acatcgcacg ccctctggat cgagagctgc agcatgagca ctccttaaag attgaggcca     2880

gggaccaagc cagagaagag cctcagctgt tctccactgt cgttgtgaaa gtatcactag     2940

aagatgttaa tgacaaccca cctacattta ttccacctaa ttatcgtgtg aaagtccgag     3000

aggatcttcc agaaggaacc gtcatcatgt ggttagaagc ccacgatcct gatttaggtc     3060

agtctggtca ggtgagatac agccttctgg accacggaga aggaaacttc gatgtggata     3120

aactcagtgg agcagttagg atcgtccagc agttggactt tgagaagaag caagtgtata     3180

atctcactgt gagggccaaa gacaagggaa agccagtttc tctgtcttct acttgctatg     3240

ttgaagttga ggtggttgat gtgaatgaga acctgcaccc acccgtgttt tccagctttg     3300

tggaaaaggg gacagtgaaa gaagatgcac ctgttggttc attggtaatg acggtgtcgg     3360

ctcatgatga ggacgccaga agagatgggg agatccgata ctccattaga gatggctctg     3420

gcgttggtgt tttcaaaata ggtgaagaga caggtgtcat agagacgtca gatcgactgg     3480

accgtgaatc gacctcccat tattggctaa cagtctttgc aaccgatcag ggtgtcgtgc     3540

ctctttcatc gttcatagag atctacatag aggttgagga tgtcaatgac aatgcaccac     3600

agacatcaga gcctgtttat tacccagaaa tcatggaaaa ttctcctaaa gatgtatctg     3660

tggtccagat cgaggcattt gatccagatt cgagctctaa tgacaagctc atgtacaaaa     3720

ttacaagtgg aaatccacaa ggattctttt caatacatcc taaaacaggt ctcatcacaa     3780

ctacgtcaag gaagctagac cgagaacagc aagatgaaca catattagag gttactgtga     3840

cagacaatgg tagtcccccc aaatcaacca ttgcaagagt cattgtgaaa atccttgatg     3900

aaaatgacaa caaacctcag tttctgcaaa agttctacaa aatcagactc cctgagcggg     3960

aaaagccaga ccgagaaaga aatgccagac gggagccgct ctatcacgtc atagccaccg     4020

acaaggatga gggccccaat gcagaaatct cctacagcat cgaagacggg aatgagcatg     4080

gcaaattttt catcgaaccg aaaactggag tggtttcgtc caagaggttt tcagcagctg     4140

gagaatatga tattctttca attaaggcag ttgacaatgg tcgccctcaa aagtcatcaa     4200

ccaccagact ccatattgaa tggatctcca agcccaaacc gtccctggag cccatttcat     4260

ttgaagaatc attttttacc tttactgtga tggaaagtga ccccgttgct cacatgattg     4320

gagtaatatc tgtggagcct cctggcatac ccctttggtt tgacatcact ggtggcaact     4380

acgacagtca cttcgatgtg gacaagggaa ctggaaccat cattgttgcc aaacctcttg     4440

atgcagaaca gaagtcaaac tacaacctca cagtcgaggc tacagatgga accaccacta     4500

tcctcactca ggtattcatc aaagtaatag acacaaatga ccatcgtcct cagttttcta     4560

catcaaagta tgaagttgtt attcctgaag atacagcgcc agaaacagaa attttgcaaa     4620

tcagtgctgt ggatcaggat gagaaaaaca aactaatcta cactctgcag agcagtagag     4680

atccactgag tctcaagaaa tttcgtcttg atcctgcaac cggctctctc tatacttctg     4740

agaaactgga tcatgaagct gttcaccagc acaccctcac ggtcatggta cgagatcaag     4800

atgtgcctgt aaaacgcaac tttgcaagga ttgtggtcaa tgtcagcgac acgaatgacc     4860

acgccccgtg gttcaccgct tcctcctaca aagggcgggt ttatgaatcg gcagccgttg     4920

gctcagttgt gttgcaggtg acggctctgg acaaggacaa agggaaaaat gctgaagtgc     4980

tgtactcgat cgagtcagga aatattggaa attcttttat gattgatcct gtcttgggct     5040

ctattaaaac tgccaaagaa ttagatcgaa gtaaccaagc ggagtatgat ttaatggtaa     5100

aagctacaga taagggcagt ccaccaatga gtgaaataac ttctgtgcgt atctttgtca     5160

caattgctga caacgcctct ccgaagttta catcaaaaga atattctgtt gaacttagtg     5220

aaactgtcag cattgggagt ttcgttggga tggttacagc ccatagtcaa tcatcagtgg     5280

tgtatgaaat aaaagatgga aatacaggtg atgcttttga tattaatcca cattctggaa     5340

ctatcatcac tcagaaagcc ctggactttg aaactttgcc catttacaca ttgataatac     5400

aaggaactaa catggctggt ttgtccacta atacaacggt tctagttcac ttgcaggatg     5460

agaatgacaa cgcgccagtt tttatgcagg cagaatatac aggactcatt agtgaatcag     5520

cctcaattaa cagcgtggtc ctaacagaca ggaatgtccc actggtgatt cgagcagctg     5580

atgctgataa agactcaaat gctttgcttg tatatcacat tgttgaacca tctgtacaca     5640

catattttgc tattgattct agcactggtg ctattcatac agtactaagt ctggactatg     5700

aagaaacaag tatttttcac tttaccgtcc aagtgcatga catgggaacc ccacgtttat     5760

ttgctgagta tgcagcgaat gtaacagtac atgtaattga cattaatgac tgcccccctg     5820

tgtttgccaa gccattatat gaagcatctc ttttgttacc aacatacaaa ggagtaaaag     5880

tcatcacagt aaatgctaca gatgctgatt caagtgcatt ctcacagttg atttactcca     5940

tcaccgaagg caacatcggg gagaagtttt ctatggacta caagactggt gctctcactg     6000

tccaaaacac aactcagtta agaagccgct acgagctaac cgttagagct tccgatggca     6060

gatttgccgg ccttacctct gtcaaaatta atgtgaaaga aagcaaagaa agtcacctaa     6120

agtttaccca ggatgtctac tctgcggtag tgaaagagaa ttccaccgag gccgaaacat     6180

tagctgtcat tactgctatt gggaatccaa tcaatgagcc tttgttttat cacatcctca     6240

acccagatcg cagatttaaa ataagccgca cttcaggagt tctgtcaacc actggcacgc     6300

ccttcgatcg tgagcagcag gaggcgtttg atgtggttgt agaagtgaca gaggaacata     6360

agccttctgc agtggcccac gttgtcgtga aggtcattgt agaagaccaa aatgataatg     6420

cgccggtgtt tgtcaacctt ccctactacg ccgttgttaa agtggacact gaggtgggcc     6480

atgtcattcg ctatgtcact gctgtagaca gagacagtgg cagaaacggg gaagtgcatt     6540

actacctcaa ggaacatcat gaacactttc aaattggacc cttgggtgaa atttcactga     6600

aaaagcaatt tgagcttgac accttaaata aagaatatct tgttacagtg gttgcaaaag     6660

atggagggaa cccggccttt tcagcggaag ttatcgttcc gatcactgtc atgaataaag     6720

ccatgcctgt gtttgaaaaa cctttctaca gtgcagagat tgcagagagc atccaggtgc     6780

acagccctgt ggtccacgtg caggctaaca gcccggaagg cctgaaagtg ttctacagca     6840

tcacagacgg agaccctttc agccagttca ctattaactt caatactgga gttatcaatg     6900

tcatagctcc tctggacttt gaggcccacc cggcatataa gctgagcata cgcgcaactg     6960

actccttgac gggcgctcat gctgaagtat ttgtggacat catagtagac gacatcaatg     7020

ataaccctcc tgtgtttgct cagcagtctt atgcggtgac cctgtctgag gcatctgtaa     7080

ttggaacgtc tgttgttcaa gttagagcca ccgattctga ttcagaacca aatagaggaa     7140

tctcatacca gatgtttggg aatcacagca agagtcatga tcattttcat gtagacagca     7200

gcactggcct catctcacta ctcagaaccc tggattacga gcagtcccgg cagcacacga     7260

tttttgtgag ggcagttgat ggtggtatgc ccacgctgag cagtgatgtg attgtcacgg     7320

tggacgttac cgacctcaat gataatccac cactctttga acaacagatt tatgaagcca     7380

gaattagcga gcacgcccct catgggcatt tcgtgacctg tgtaaaagcc tatgatgcag     7440

acagttcaga catagacaag ttgcagtatt ccattctgtc tggcaatgat cataaacatt     7500

ttgtcattga cagtgcaaca gggattatca ccctctcaaa cctgcaccgg cacgccctga     7560

agccatttta cagtcttaac ctgtcagtgt ctgatggagt ttttagaagt tccacccagg     7620

ttcatgtaac tgtaattgga ggcaatttgc acagtcctgc tttccttcag aacgaatatg     7680

aagtggaact agctgaaaac gctcccctac ataccctggt gatggaggtg aaaactacgg     7740

atggggattc tggtatttat ggtcacgtta cttaccatat tgtaaatgac tttgccaaag     7800

acagatttta cataaatgag agaggacaga tatttacttt ggaaaaactt gatcgagaaa     7860

ccccggcgga gaaagtgatc tcagtccgtt taatggctaa ggatgctgga ggaaaagttg     7920

ctttctgcac cgtgaatgtc atccttacag atgacaatga caatgcacca caatttcgag     7980

caaccaaata cgaagtgaat atcgggtcca gtgctgctaa agggacttca gtcgttaaag     8040

ttcttgcaag tgatgccgat gagggctcca atgccgacat cacctatgcc attgaagcag     8100

actctgaaag tgtaaaagag aatttggaaa ttaacaaact gtccggcgta atcactacaa     8160

aggagagcct cattggcttg gaaaatgaat tcttcacttt ctttgttaga gctgtggata     8220

atgggtctcc atcaaaagaa tctgttgttc ttgtctatgt taaaatcctt ccaccggaaa     8280

tgcagcttcc aaaattttca gaacctttct atacctttac agtgtcagag gacgtgccta     8340

ttggaacaga gatagatctc atccgagcag aacatagtgg gactgttctt tacagcctgg     8400

tcaaagggaa tactccagaa agcaataggg atgagtcctt tgtgattgac agacagagcg     8460

ggagactgaa gttggagaag agtcttgatc atgagacaac taagtggtat cagttttcca     8520

tactggccag gtgcactcaa gatgaccatg agatggtggc ttctgtagat gttagtatcc     8580

aagtgaaaga tgcaaatgac aacagcccgg tctttgaatc tagtccatat gaggcattca     8640

ttgttgaaaa cctgccaggg ggaagtagag taattcagat cagggcatct gatgctgact     8700

caggaaccaa cggccaagtt atgtatagcc tggatcagtc acaaagtgtg gaagtcattg     8760

aatcctttgc cattaacatg gaaacaggct ggattacaac tttaaaggaa cttgaccatg     8820

aaaagagaga caattaccag attaaagtgg ttgcatcaga tcatggtgaa aagatccagc     8880

tatcctccac agccattgtg gatgttaccg tcaccgatgt caacgatagt ccaccacgat     8940

tcacggccga gatctataaa gggactgtga gtgaggatga cccccaaggt ggggtgattg     9000

ccatcttaag taccacggat gctgattctg aagagatcaa cagacaagtt acatatttca     9060

taacaggagg ggatccttta ggacagtttg ccgttgaaac tatacagaat gaatggaagg     9120

tatatgtgaa gaaacctcta gacagggaaa aaagggacaa ttaccttctt actatcacgg     9180

caactgatgg caccttctca tcaaaagcga tagttgaagt gaaagttctg gatgcaaatg     9240

acaacagtcc agtttgtgaa aagactttat attcagacac tattcctgaa gacgtccttc     9300

ctggaaaatt gatcatgcag atctctgcta cagacgcaga catccgctct aacgctgaaa     9360

ttacttacac gttattgggt tcaggtgcag aaaaattcaa actaaatcca gacacaggtg     9420

aactgaaaac gtcaaccccc cttgatcgtg aggagcaagc tgtttatcat cttctcgtca     9480

gggccacaga tggaggagga agattctgcc aagccagtat tgtgctcacg ctagaagatg     9540

tgaacgataa cgcccccgaa ttctctgccg atccttatgc catcaccgtg tttgaaaaca     9600

cagagccggg aacgctgctg acaagagtgc aggccacaga tgccgacgca ggattaaatc     9660

ggaagatttt atactcactg attgactctg ctgatgggca gttctccatt aacgaattat     9720

ctggaattat tcagttagaa aaacctttgg acagagaact ccaggcagta tacaccctct     9780

ctttgaaagc tgtggatcaa ggcttgccaa ggaggctgac tgccactggc actgtgattg     9840

tatcagttct tgacataaat gacaaccccc ctgtgtttga gtaccgtgaa tatggtgcca     9900

ccgtgtctga ggacattctt gttggaactg aagttcttca agtgtatgca gcaagtcggg     9960

atattgaagc aaatgcagaa atcacctact caataataag tggaaatgaa catgggaaat    10020

tcagcataga ttctaaaaca ggggccgtat ttatcattga gaatctggat tatgagagct    10080

ctcatgagta ttacctaaca gtagaggcca ctgatggagg cacgccttca ctgagcgacg    10140

ttgccactgt gaacgttaat gtaacagata tcaacgataa tacccctgtg ttcagccaag    10200

acacctacac gacagtcatc agtgaagatg ccgttcttga gcagtctgtc atcacggtta    10260

tggccgatga tgccgatgga ccttccaaca gccacatcca ctactcaatt atagatggca    10320

accaaggaag ctcgttcaca attgaccccg tcaggggaga agtcaaagtg accaaacttc    10380

tcgaccgaga aacgatttca ggttacacgc tcacggttca agcttctgat aatggcagtc    10440

cacccagagt caacacgacg accgtgaaca tcgatgtgtc cgatgtcaat gacaacgcgc    10500

ccgtcttctc caggggaaac tacagtgtca ttatccagga aaataagcca gtgggcttca    10560

gcgtgctgca gctggtagta acagatgagg attcttccca taacggtcca cccttcttct    10620

ttactattgt aactggaaat gatgagaagg cttttgaagt taacccgcaa ggagtcctcc    10680

tgacatcatc tgccatcaag aggaaggaga aagatcatta cttactgcag gtgaaggtgg    10740

cagataatgg aaagcctcag ttgtcatctt tgacatacat tgacattagg gtaattgagg    10800

agagcatcta tccgcctgcg attttgcccc tggagatttt catcacctct tctggagaag    10860

aatactcagg tggcgtcatt gggaagatcc atgccacaga ccaggacgtg tatgatactc    10920

taacctacag tctcgaccct cagatggaca acctgttctc tgtttccagc acagggggca    10980

agctgatagc acacaaaaag ctagacatag ggcaatacct tctcaatgtc agcgtaacag    11040

atgggaagtt cacgacggtg gccgacatca cagtgcatat cagacaagtc acacaggaga    11100

tgttgaacca caccatcgcg atccgctttg ccaacctcac tccggaagaa ttcgttggtg    11160

actactggcg caacttccag cgagctttac ggaacatcct gggtgtgagg aggaacgaca    11220

tacagattgt tagtttgcag tcctctgaac ctcacccaca tctggacgtc ttactttttg    11280

tagagaaacc aggtagtgct cagatctcaa caaaacaact tctgcacaag attaactctt    11340

ccgtgactga cattgaggaa atcattggag ttaggatact gaatgtattc cagaaactct    11400

gcgcgggact ggactgcccc tggaagttct gcgatgaaaa ggtgtctgtg gatgaaagtg    11460

tgatgtcaac acacagcaca gccagactga gttttgtgac tccccgccac cacagggcag    11520

cggtgtgtct ctgcaaagag ggaaggtgcc cacctgtcca ccatggctgt gaagatgatc    11580

cgtgccctga gggatccgaa tgtgtgtctg atccctggga ggagaaacac acctgtgtct    11640

gtcccagcgg caggtttggt cagtgcccag ggagttcatc tatgacactg actggaaaca    11700

gctacgtgaa ataccgtctg acggaaaatg aaaacaaatt agagatgaaa ctgaccatga    11760

ggctcagaac atattccacg catgcggttg tcatgtatgc tcgaggaact gactatagca    11820

tcttggagat tcatcatgga aggctgcagt acaagtttga ctgtggaagt ggccctggaa    11880

ttgtctctgt tcagagcatt caggtcaatg atgggcagtg gcacgcagtg gccctggaag    11940

tgaatggaaa ctatgctcgc ttggttctag accaagttca tactgcatcg ggcacagccc    12000

cagggactct gaaaaccctg aacctggata actatgtgtt ttttggtggc cacatccgtc    12060

agcagggaac aaggcatgga agaagtcctc aagttggtaa tggtttcagg ggttgtatgg    12120

actccattta tttgaatggg caggagctcc ctttaaacag caaacccaga agctatgcac    12180

acatcgaaga gtcggtggat gtatctccag gctgcttcct gacggccacg gaagactgcg    12240

ccagcaaccc ttgccagaat ggaggcgttt gcaatccgtc acctgctgga ggttattact    12300

gcaaatgcag tgccttgtac atagggaccc actgtgagat aagcgtcaat ccgtgttcct    12360

ccaagccatg cctctatggg ggcacgtgtg ttgtcgacaa cggaggcttt gtttgccagt    12420

gtagaggatt atatactggt cagaggtgtc agcttagtcc atactgcaaa gatgaaccct    12480

gtaagaatgg cggaacatgc tttgacagtt tggatggcgc cgtttgtcag tgtgattcgg    12540

gttttagggg agaaaggtgt cagagtgata tcgacgagtg ctctggaaac ccttgcctgc    12600

acggggccct ctgtgagaac acgcacggct cctatcactg caactgcagc cacgagtaca    12660

ggggacgtca ctgcgaggat gctgcgccca accagtatgt gtccacgccg tggaacattg    12720

ggttggcgga aggaattgga atcgttgtgt ttgttgcagg gatattttta ctggtggtgg    12780

tgtttgttct ctgccgtaag atgattagtc ggaaaaagaa gcatcaggct gaacctaaag    12840

acaagcacct gggacccgct acggctttct tgcaaagacc gtattttgat tccaagctaa    12900

ataagaacat ttactcagac ataccacccc aggtgcctgt ccggcctatt tcctacaccc    12960

cgagtattcc aagtgactca agaaacaatc tggaccgaaa ttccttcgaa ggatctgcta    13020

tcccagagca tcccgaattc agcactttta accccgagtc tgtgcacggg caccgaaaag    13080

cagtggcggt ctgcagcgtg gcgccaaacc tgcctccccc acccccttca aactcccctt    13140

ctgacagcga ctccatccag aagcctagct gggactttga ctatgacaca aaagtggtgg    13200

atcttgatcc ctgtctttcc aagaagcctc tagaggaaaa gccttcccag ccatacagtg    13260

cccgggaaag cctgtctgaa gtgcagtctc tgagctcctt ccagtccgaa tcgtgcgatg    13320

acaatgggta tcactgggat acatcagatt ggatgccaag cgttcctctg ccggacatac    13380

aagagttccc caactatgag gtgattgatg agcagacacc cctgtactca gcagatccaa    13440

acgccatcga tacggactat taccctggag gctacgacat cgaaagtgat tttcctccac    13500

ccccagaaga cttccccgca gctgatgagc taccaccgtt accgcccgaa ttcagcaatc    13560

agtttgaatc catccaccct cctagagaca tgcctgccgc gggtagcttg ggttcttcat    13620

caagaaaccg gcagaggttc aacttgaatc agtatttgcc caatttttat cccctcgata    13680

tgtctgaacc tcaaacaaaa ggcactggtg agaatagtac ttgtagagaa ccccatgccc    13740

cttacccgcc agggtatcaa agacacttcg aggcgcccgc tgtcgagagc atgcccatgt    13800

ctgtgtacgc ctccaccgcc tcctgctctg acgtgtcagc ctgctgcgaa gtggagtccg    13860

aggtcatgat gagtgactat gagagcgggg acgacggcca cttcgaagag gtgacgatcc    13920

cgcccctgga ttcccagcag cacacggaag tctgactctc aactcccccc aaagtgcctg    13980

actttagtga acctagaggt gatgtgagta atccgcgctg ttctttgcag cagtgcttcc    14040

aagctttttt tggtgagccg aatgggcatg gctgcgctgg atcctgcgcc tctggacgtg    14100

ctagccattt ccagtgtccc aactactgtc atcgtgaggt tttcatcggc tgtgccattt    14160

cccaacgtct tttgggattt acatctgtct gtgttaaaat aatcaaacga aaaatcagtc    14220

ctgtgttgtc agcatgattc atgtatttat atagatttga ttattttaat tttcctgtct    14280

cttttttttg taaattttat gtacagattt gatttttcat agttttaact agatttccaa    14340

gatattttgt gcatttgttt caactgaatt ttggtggtgt cagtgccatt atctagcacc    14400

ctgatttttt tttttttact ataaccaggg tttcattctg tctttttcca ctgaagtgtg    14460

acattttgtt agtacatttc agtgtagtca ttcatttcta gctgtacata ggatgaagga    14520

gagatcagat acatgaacat gtcttacatg ggttgctgta tttagaatta taaacatttt    14580

tcattattgg aaagtgtaac ggggaccttc tgcatacctg tttagaacca aaaccaccat    14640

gacacagttt ttatagtgtc tgtatatttg tgatgcaatg gtcttgtaaa ggtttttaat    14700

gaaaactacc attagccagt ctttcttact gacaataaat tattaataaa atacttgagc    14760

tttaaaaaaa aaa                                                       14773


<210>  234
<211>  4588
<212>  PRT
<213>  homo sapiens

<400>  234

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  235
<211>  6475
<212>  DNA
<213>  homo sapiens

<400>  235
gagagccccc ggtggggccg gcggaggagc gcccttcccc ccgcgcgctg attgctgtgg       60

cgtcctgccc gtccccgccc gcgtgtgtgc gagggagggc gagtgcgccg ggtcggcctg      120

atgggggtaa tcgagggttt cggggacgcc gagcggcact ttcctcttcc cagcgagtga      180

aggagggcag tcggcggctc tcgcgccccg gccactttcc ctgcgcgatt cccggagctc      240

cctgcaggag gtgagagtcc ccagcgggtc cggatggcgt agttttgccg cggcgcagca      300

gctgccggag ctcgccgccg ccgagcgctg ggcggggaaa cttgccgccg ctttcctcca      360

acttgctgcg ggtggatctc cgctggacac accgcctccg aggcagtttg aaaattgcaa      420

ggagggactt taagactact tctgatttgc aaagattgtc tgtgctctga gcaggctgaa      480

gtgactggac gagacgcact gttggagaaa taaaaatgac ttcccattat gtgattgcca      540

tctttgccct gatgagctcc tgtttagcca ctgcaggtcc agagcctggt gcactgtgtg      600

aactgtcacc tgtcagtgcc tcccatcctg tccaggcctt gatggagagc ttcactgttt      660

tgtcaggctg tgccagcaga ggcacaactg ggctgccaca ggaggtgcat gtcctgaatc      720

tccgcactgc aggccagggg cctggccagc tacagagaga ggtcacactt cacctgaatc      780

ccatctcctc agtccacatc caccacaagt ctgttgtgtt cctgctcaac tccccacacc      840

ccctggtgtg gcatctgaag acagagagac ttgccactgg ggtctccaga ctgtttttgg      900

tgtctgaggg ttctgtggtc cagttttcat cagcaaactt ctccttgaca gcagaaacag      960

aagaaaggaa cttcccccat ggaaatgaac atctgttaaa ttgggcccga aaagagtatg     1020

gagcagttac ttcattcacc gaactcaaga tagcaagaaa catttatatt aaagtggggg     1080

aagatcaagt gttccctcca aagtgcaaca tagggaagaa ttttctctca ctcaattacc     1140

ttgctgagta ccttcaaccc aaagcagcag aagggtgtgt gatgtccagc cagccccaga     1200

atgaggaagt acacatcatc gagctaatca cccccaactc taacccctac agtgctttcc     1260

aggtggatat aacaattgat ataagacctt ctcaagagga tcttgaagtg gtcaaaaatc     1320

tcatcctgat cttgaagtgc aaaaagtctg tcaactgggt gatcaaatct tttgatgtta     1380

agggaagcct gaaaattatt gctcctaaca gtattggctt tggaaaagag agtgaaagat     1440

ctatgacaat gaccaaatca ataagagatg acattccttc aacccaaggg aatctggtga     1500

agtgggcttt ggacaatggc tatagtccaa taacttcata cacaatggct cctgtggcta     1560

atagatttca tcttcggctt gaaaataatg cagaggagat gggagatgag gaagtccaca     1620

ctattcctcc tgagctacgg atcctgctgg accctggtgc cctgcctgcc ctgcagaacc     1680

cgcccatccg gggaggggaa ggccaaaatg gaggccttcc gtttcctttc ccagatattt     1740

ccaggagagt ctggaatgaa gagggagaag atgggctccc tcggccaaag gaccctgtca     1800

ttcccagcat acaactgttt cctggtctca gagagccaga agaggtgcaa gggagcgtgg     1860

atattgccct gtctgtcaaa tgtgacaatg agaagatgat cgtggctgta gaaaaagatt     1920

cttttcaggc cagtggctac tcggggatgg acgtcaccct gttggatcct acctgcaagg     1980

ccaagatgaa tggcacacac tttgttttgg agtctcctct gaatggctgc ggtactcggc     2040

cccggtggtc agcccttgat ggtgtggtct actataactc cattgtgata caggttccag     2100

cccttgggga cagtagtggt tggccagatg gttatgaaga tctggagtca ggtgataatg     2160

gatttccggg agatatggat gaaggagatg cttccctgtt cacccgacct gaaatcgtgg     2220

tgtttaattg cagccttcag caggtgagga accccagcag cttccaggaa cagccccacg     2280

gaaacatcac cttcaacatg gagctataca acactgacct ctttttggtg ccctcccagg     2340

gcgtcttctc tgtgccagag aatggacacg tttatgttga ggtatctgtt actaaggctg     2400

aacaagaact gggatttgcc atccaaacgt gctttatctc tccatattcg aaccctgata     2460

ggatgtctca ttacaccatt attgagaata tttgtcctaa agatgaatct gtgaaattct     2520

acagtcccaa gagagtgcac tttcctatcc cgcaagctga catggataag aagcgattca     2580

gctttgtctt caagcctgtc ttcaacacct cactgctctt tctacagtgt gagctgacgc     2640

tgtgtacgaa gatggagaag cacccccaga agttgcctaa gtgtgtgcct cctgacgaag     2700

cctgcacctc gctggacgcc tcgataatct gggccatgat gcagaataag aagacgttca     2760

ctaagcccct tgctgtgatc caccatgaag cagaatctaa agaaaaaggt ccaagcatga     2820

aggaaccaaa tccaatttct ccaccaattt tccatggtct ggacacccta accgtgatgg     2880

gcattgcgtt tgcagccttt gtgatcggag cactcctgac gggggccttg tggtacatct     2940

attctcacac aggggagaca gcaggaaggc agcaagtccc cacctccccg ccagcctcgg     3000

aaaacagcag tgctgcccac agcatcggca gcacgcagag cacgccttgc tccagcagca     3060

gcacggccta gcccaaccca gcccaacccg gcccaaccca gcccagccca gctcagctca     3120

gctactgcca agggcaggac caatggctga gcctcgtgtc cagactcaga gggctggatt     3180

ttggttccct tgtaaagaca gagtgaattt cagtataaag atcacccgtt gtattcaccc     3240

cacacccagg gctagtataa acatgaccct gggcttctgt accacactag aattcatgtg     3300

agaaagctaa aatggtggtc ttctccacca gcccctcaca ggcttggggg ttttcaatgt     3360

gaaacacatg ccagttttta aaatgctgct ttgtccaggt gagaacatcc ataatttggg     3420

gccctgagtt ttacccagac tcaaggagtt ggtaaagggt taatagccag atagtagaac     3480

cagtgaggag atgcggccaa agattcttta tatctgaacc aagatgtaaa acaagaaatg     3540

ctttgaggct ttctaagcga tcctcctgtc taatttgcac ctttgtctgg atgcacactt     3600

ctgaccttgc tgccacaacc tgtggggtct gatgtgtccc ttgatgggtg ctgccctcag     3660

ggactgcacc ctgacaagtg ttaaggcaac attcctttct tgtgccctgg gccaaaacca     3720

atgctgatga ccttatcagc ttcctgtttc ttcccatact tgcatacacc actgcaaaat     3780

gtcttaatgc aaattttgta tttcttacag gcctacagaa attgaaaatg accaaaatca     3840

ggaaccacag atttgtgccc attcctaata ttttgttctg caaattaatg tataatttga     3900

ggtgaaattc agttataaag tcaaggacga atttgcacag tgatatattt ctatgtgtat     3960

gcaagtacaa gtatataata tgtcacctgg cacattcatt ttctcagttg aagaagagaa     4020

aatttgaaaa tgtccttatg cttttagagt tgcaacttaa gtatatttgg tagggtgagt     4080

gtttccactc aaaatatgtc aacttaaaaa aaaataggcc ctttcataaa aaccaaactg     4140

tagcaagatg caaatgcatg gcaaatcctg tcggtctcca gttggttatc tgaatagtgt     4200

caccaattcc accaagacag tgctgagatt ggaaaagggc actcatttgg attgccttac     4260

ttctcttgcc ttaaatatat cccatatatt taatatgtca aaaagggctt gaggtgaatt     4320

tcattaaatg gaataatatg atgccacttt gcagctaaaa taagctcagt gatacctcct     4380

tgttaaaaaa aaaaaaaaaa aaaaagaatg ccagggggga attatcatgc taaattattt     4440

tactgctgaa gatagcttca ttgcaaatta ttctttttcc agaatttccc ccaaacaact     4500

tagaattcca taagtagaac aagatagatt ctacccccaa aatattcata agcaaatccc     4560

actgccctta aaataaggaa gttatgcctg gttgtctgtg aatggaacct cagtaggtaa     4620

tcctgatgaa gcttaaaacc ttagggcagt gtctacatgg gaaacaagta tgtggaaatt     4680

gacaatcatt tttaccaaat cgttgagtaa taatatgact tacctgatag atatacacat     4740

tcaataagga acattttttt ttttcaataa ggaacatttt aactaaaaca ttactttagg     4800

gctgagattt ccaggctatc tacattgatc tactgaaaaa tttctagatt tccatataca     4860

aacgaagaag acatgagttt agagaatttt tttcctttaa ttttttttta acagaagggt     4920

atcagagtgg aggacctaga ttacgctacc tgtgtttgaa aatattgcgc tttgcctaac     4980

cttcggtgga atgtattgtt tcagcatatt ctatgtataa aaaagtttaa agatgtcttc     5040

aaagaagact agagtcttta agtcacttat agctatattt tactacaaaa tttgtgtata     5100

aagatatatt taagtgtttt agataaattt aagttactcc atatgaaatg tttaatttca     5160

gctactgtga attctttcga tcagtccttt gcttttttaa aaaatctttt ccatcgtgtt     5220

aaaaagaaaa ttagctatta ggagatatta aaagattgat gtcttagaag gacagggtta     5280

aaaccttctg taatatattt aaatatatat ttttaagaga gatgctacat tgccaatgat     5340

tttataaata atttaaaatt aatttacaaa tttatagatg caaaccaaaa gatcttttta     5400

aaagagagag agaggaaaaa aatcaccttt tatttgtttg ggtctcattg tcagaattat     5460

tattcagatc aagaaatctg tgtcgataaa acctaatctc atattggaga gtgaatgtcg     5520

ttaagtattt ctgaaatgtt tctaaaaaat gaacatgaaa aaaataaggt attttctccc     5580

tagcttctca ttacagtatt tctaattgct tcacacttta cagttttaat acaaagtaca     5640

agctctactt ttataacgtg tactacaagt ttctttaaaa gtattgttgt atttcagctg     5700

aactcttgta tctgcagtct tttgttattt ctgcaggcta cacccttaat ttgcagaggc     5760

cattttgttg tttgtttgat gctgaagctg ttgttaaaat gccccaaact ccaaggcaga     5820

ttgtctgtat aatacgctat agcttttcac catgtggtgt ttaccagctg ttactctgta     5880

ttttaaaaag ccagagattt cttctgtcta aactgtttct atagcatttt ctaaacaaaa     5940

aaaatggttt ttttctttgc cttgtaataa gattgtaaat ccatttcctg cttgtgttct     6000

tagtgggcat gattgtgagt gtgtgtgggg tgctcacacg cgtgccagtc tttttgtact     6060

gtaactacct catggtttga atgatgattg tactgctggt tgtgttaaca gagcacattt     6120

tgttgggtga gtcctatgtg atttttttca tgtttgtttt atctgggggt tgttcatgaa     6180

actgacagat gtttttctaa aaaggactat tatcagtttc caaatacaat acttctctct     6240

tctggttttt cctgaatgag cctgattttg ttgctggttt tcatcatcta tgagggtaaa     6300

acgagtaccc ttaaaatccc tgtggccagt ttgaacaccc ctgttgtatt cttttctctg     6360

ttcagtgtgt cagctatttt gtgaagatgc ttagatgtat agttttgata accacagttt     6420

taaatctttt atctgtgcat aataaaaaga tatatatcag ttattaaaaa aaaaa          6475


<210>  236
<211>  851
<212>  PRT
<213>  homo sapiens

<400>  236

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  237
<211>  6256
<212>  DNA
<213>  homo sapiens

<400>  237
gcggccgccg cctccgcccc gcgttcgggg ccttcccgac cctgcactgc tgccgtccgc       60

ccgcccggcc gctcttctct tcgccgtggg agccgctccg ggcgcagggc cgcgcgccga      120

gccccgcagg ctgcagcgcc gcggcccggc ccggcgcccc ggcaacttcg ccgagagttg      180

aggcgaagtt tgggcgaccg cggcaggccc cggccgagct cccctctgcg cccccggcgt      240

cccgtcgagc ccagccccgc cgggggcgct cctcgccgcc cgcgcgccct ccccagccat      300

gtcgtccatc ctgcctttca ctcccccgat cgtgaagcgc ctgctgggct ggaagaaggg      360

cgagcagaac gggcaggagg agaaatggtg cgagaaggcg gtcaagagcc tggtcaagaa      420

actcaagaag acggggcagc tggacgagct ggagaaggcc atcaccacgc agaacgtcaa      480

caccaagtgc atcaccatcc ccaggtccct ggatggccgg ttgcaggtgt cccatcggaa      540

ggggctccct catgtcatct actgccgcct gtggcgatgg ccagacctgc acagccacca      600

cgagctacgg gccatggagc tgtgtgagtt cgccttcaat atgaagaagg acgaggtctg      660

cgtgaatccc taccactacc agagagtaga gacaccagtt ctacctcctg tgttggtgcc      720

acgccacaca gagatcccgg ccgagttccc cccactggac gactacagcc attccatccc      780

cgaaaacact aacttccccg caggcatcga gccccagagc aatattccag agaccccacc      840

ccctggctac ctgagtgaag atggagaaac cagtgaccac cagatgaacc acagcatgga      900

cgcaggttct ccaaacctat ccccgaatcc gatgtcccca gcacataata acttggacct      960

gcagccagtt acctactgcg agccggcctt ctggtgctcc atctcctact acgagctgaa     1020

ccagcgcgtc ggggagacat tccacgcctc gcagccatcc atgactgtgg atggcttcac     1080

cgacccctcc aattcggagc gcttctgcct agggctgctc tccaatgtca acaggaatgc     1140

agcagtggag ctgacacgga gacacatcgg aagaggcgtg cggctctact acatcggagg     1200

ggaggtcttc gcagagtgcc tcagtgacag cgctattttt gtccagtctc ccaactgtaa     1260

ccagcgctat ggctggcacc cggccaccgt ctgcaagatc ccaccaggat gcaacctgaa     1320

gatcttcaac aaccaggagt tcgctgccct cctggcccag tcggtcaacc agggctttga     1380

ggctgtctac cagttgaccc gaatgtgcac catccgcatg agcttcgtca aaggctgggg     1440

agcggagtac aggagacaga ctgtgaccag taccccctgc tggattgagc tgcacctgaa     1500

tgggcctttg cagtggcttg acaaggtcct cacccagatg ggctccccaa gcatccgctg     1560

ttccagtgtg tcttagagac atcaagtatg gtaggggagg gcaggcttgg ggaaaatggc     1620

catgcaggag gtggagaaaa ttggaactct actcaaccca ttgttgtcaa ggaagaagaa     1680

atctttctcc ctcaactgaa ggggtgcacc cacctgtttt ctgaaacaca cgagcaaacc     1740

cagaggtgga tgttatgaac agctgtgtct gccaaacaca tttacccttt ggccccactt     1800

tgaagggcaa gaaatggcgt ctgctctggt ggcttaagtg agcagaacag gtagtattac     1860

accaccggcc ccctcccccc agactctttt tttgagtgac agctttctgg gatgtcacag     1920

tccaaccaga aacacccctc tgtctaggac tgcagtgtgg agttcacctt ggaagggcgt     1980

tctaggtagg aagagcccgc agggccatgc agacctcatg cccagctctc tgacgcttgt     2040

gacagtgcct cttccagtga acattcccag cccagccccg ccccgccccg ccccaccact     2100

ccagcagacc ttgccccttg tgagctggat agacttggga tggggaggga gggagttttg     2160

tctgtctccc tcccctctca gaacatactg attgggaggt gcgtgttcag cagaacctgc     2220

acacaggaca gcgggaaaaa tcgatgagcg ccacctcttt aaaaactcac ttacgtttgt     2280

cctttttcac tttgaaaagt tggaaggatc tgctgaggcc cagtgcatat gcaatgtata     2340

gtgtctatta tcacattaat ctcaaagaga ttcgaatgac ggtaagtgtt ctcatgaagc     2400

aggaggccct tgtcgtggga tggcatttgg tctcaggcag caccacactg ggtgcgtctc     2460

cagtcatctg taagagcttg ctccagattc tgatgcatac ggctatattg gtttatgtag     2520

tcagttgcat tcattaaatc aactttatca tatgctcttt taaatgtttg gtttatatat     2580

tttctttaaa aatcctgggc tggcacattg actgggaaac ctgagtgaga cccagcaact     2640

gcttctctcc cttctctctc ctgaggtgaa gcttttccag gttttgttga agagatacct     2700

gccagcactt ctgcaagctg aaatttacag aagcaaattc accagaaggg aaacatctca     2760

ggccaacata ggcaaatgaa aagggctatt aaaatatttt tacacctttg aaaattgcag     2820

gcttggtaca aagaggtctg tcatcttccc cctgggatat aagatgatct agctcccggt     2880

agaggatcac cggtgacaac tatagcagtt gtattgtgta acaagtactg ctcccagcag     2940

caattaggga gaaaactagt ctaaattatt tcaactggaa aaaagaaaaa agagtcctct     3000

tcttttccca gccttttgca gaacacagta gacagaactg ccaccttcaa ttggtacttt     3060

attctttgct gctgtttttg tataaaatga cctatcccac gtttttgcat gaatttatag     3120

caggaaaaat caagggattt cctatggaag tcctgcttta ttccaggtga agggaaggaa     3180

gtgtatatac ttttggcaag tcatacagct caaatgtgat gagatttctg atgttagagg     3240

gagatggaga ggcttcctga tgcctcatct gcagggtcct gtgcctctga agttctagcc     3300

atgaggtttc caggtaggac agctgctccc caagcctcct gaggacacag gaagagacgg     3360

aaggagcacc ttgacagact tgtgtgagtc ttctcgaagg agggttgact cagaacccag     3420

agacaataca aaacccctca cttcctctga gagggccaaa tgctgtgagt ctgaagtatg     3480

tgcctggtgt gaaatgatct atggcctgtt tcttacacag gaagccccct gaacctcctg     3540

tacatgtgtt catgttccca gccagctctg agacccagga accaaatatt ccattttggc     3600

ttctgctaga gcagtcatgg ttcctctcct aaaagccatg ggcagcagtt tccgagggcc     3660

tgcatgatcc acctgctgca cgatcctatg agggcttcct gtggcacaca gccctctggg     3720

tgcttgggaa ctagcttcag gcacagcctg attctggtga tccagtgatc tatggaagtc     3780

gtgtcttact ccaggtgaag ggggaaaaaa aaagcctata ctttggcagg ttatgaactt     3840

tgaatgtgat gaaatgacac gtttggctgc atttggatgg tgtcttagaa ccctcattgc     3900

tcagacctga aggctacttc taggagcatg aagtttgagt tttgtgtttt tccaaaggat     3960

acttccttgg ccctttttct ttattgacta gaccaccaga ggaggatgtg tgggattgta     4020

ggcaaaccca cctgtggcat cactgaaaat aaatttgatc atacctaaga ggttaggaaa     4080

tggtgccatt cccaccttag agtgctacat aggtgctttg ggcgtatgta acattagtgt     4140

ccttccttga agccacaagc tagttttctt agttttaaaa tcctgttgta tgaatggcat     4200

ttgtatatta aaacactttt ttaaaggaca gttgaaaagg gcaagaggaa accagggcag     4260

ttctagagga gtgctggtga ctggatagca gttttaagtg gcgttcacct agtcaacacg     4320

accgcgtgtg ttgcccctgc cctgggctcc ccgccatgac atcttcacct tgcagcttgt     4380

gctgagactg acccaagtgc agctagcact gggacacaga tccttgtctt cagcaccttc     4440

caaggagcca acttttattc cctttcctct ctcccctccc cacctcgctt cttcccaatt     4500

tagtaactta gatgcttcca gcacatacgt aggtagctac cccagccggt ttggattaca     4560

ggcctgtgct ggaacatcat ctcagttggc caccttcctg gcaggctgta gacctgacat     4620

tttgagacaa gcctagagtc aggagcaggg actttgactc ttaggaagag cacacatgag     4680

ggcaaggctg ctggcagacg tctccattgt ccttatgttg tctgtgttgt attttttttt     4740

ttttattgac catggtgatt atttttttaa accatcgtta atatactgaa gtgagctata     4800

gcacatatca tgtgcttagt ttgtttattt ttctccatct ccccttggct tcctagagtt     4860

tggacatatt ccaggctaaa tgcttttact caagactaca gaaaggtttg aagtagtgtg     4920

tgcatggcat gcacgtatgt aagtaatctg gggaagaagc aaagatctgt ttcattctta     4980

gcctcaggcc tcatgagggt ctccacaggg ccggagctca ggttacacca ctccttcgtc     5040

cttacaggag atgtagggag aagaatctgc aggctgcttg taggactgtt caccaagggg     5100

gataccagca gcaagagagt gcacccgttt agccctggac cctgtttctt actgtgtgac     5160

ttggctagag ttgggagttc ccccaaaata aacgtgtccc cattttacca gaaccaaacc     5220

tcaacacagc gaagctgtac tgtctttgtg tggcaaagat gttcccttgt aggccccttt     5280

caggtaaccg tcttcacaat gtattttcat cacagtttaa ggagcatcag ccgcttctca     5340

agtgggtagg gaaagcagaa aaacgtacgc aagaggacat ggatccaaaa tgatgatgaa     5400

gcatctccca tggggaggtg atggtgggga gatgatgggc taaacaggca acttttcaaa     5460

aacacagcta tcatagaaaa gaaacttgcc tcatgtaaac tggattgaga aattctcagt     5520

gattctgcaa tggatttttt tttaatgcag aagtaatgta tactctagta ttctggtgtt     5580

tttatattta tgtaataatt tcttaaaacc attcagacag ataactattt aatttttttt     5640

aagaaagttg gaaaggtctc tcctcccaag gacagtggct ggaagagttg gggcacagcc     5700

agttctgaat gttggtggag ggtgtagtgg ctttttggct cagcatccag aaacaccaaa     5760

ccaggctggc taaacaagtg gccgcgtgta aaaacagaca gctctgagtc aaatctgggc     5820

ccttccacaa gggtcctctg aaccaagccc cactcccttg ctaggggtga aagcattaca     5880

gagagatgga gccatctatc caagaagcct tcactcacct tcactgctgc tgttgcaact     5940

cggctgttct ggactctgat gtgtgtggag ggatggggaa tagaacattg actgtgttga     6000

ttaccttcac tattcggcca gcctgacctt ttaataactt tgtaaaaagc atgtatgtat     6060

ttatagtgtt ttagattttt ctaactttta tatcttaaaa gcagagcacc tgtttaagca     6120

ttgtacccct attgttaaag atttgtgtcc tctcattccc tctcttcctc ttgtaagtgc     6180

ccttctaata aacttttcat ggaaaagctc ctgtgccagg agctcagtct gaaaaaaaaa     6240

aaaaaaaaaa aaaaaa                                                     6256


<210>  238
<211>  425
<212>  PRT
<213>  homo sapiens

<400>  238

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Ile Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Gly Glu Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu 
            20                  25                  30          


Lys Ala Val Lys Ser Leu Val Lys Lys Leu Lys Lys Thr Gly Gln Leu 
        35                  40                  45              


Asp Glu Leu Glu Lys Ala Ile Thr Thr Gln Asn Val Asn Thr Lys Cys 
    50                  55                  60                  


Ile Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His Arg 
65                  70                  75                  80  


Lys Gly Leu Pro His Val Ile Tyr Cys Arg Leu Trp Arg Trp Pro Asp 
                85                  90                  95      


Leu His Ser His His Glu Leu Arg Ala Met Glu Leu Cys Glu Phe Ala 
            100                 105                 110         


Phe Asn Met Lys Lys Asp Glu Val Cys Val Asn Pro Tyr His Tyr Gln 
        115                 120                 125             


Arg Val Glu Thr Pro Val Leu Pro Pro Val Leu Val Pro Arg His Thr 
    130                 135                 140                 


Glu Ile Pro Ala Glu Phe Pro Pro Leu Asp Asp Tyr Ser His Ser Ile 
145                 150                 155                 160 


Pro Glu Asn Thr Asn Phe Pro Ala Gly Ile Glu Pro Gln Ser Asn Ile 
                165                 170                 175     


Pro Glu Thr Pro Pro Pro Gly Tyr Leu Ser Glu Asp Gly Glu Thr Ser 
            180                 185                 190         


Asp His Gln Met Asn His Ser Met Asp Ala Gly Ser Pro Asn Leu Ser 
        195                 200                 205             


Pro Asn Pro Met Ser Pro Ala His Asn Asn Leu Asp Leu Gln Pro Val 
    210                 215                 220                 


Thr Tyr Cys Glu Pro Ala Phe Trp Cys Ser Ile Ser Tyr Tyr Glu Leu 
225                 230                 235                 240 


Asn Gln Arg Val Gly Glu Thr Phe His Ala Ser Gln Pro Ser Met Thr 
                245                 250                 255     


Val Asp Gly Phe Thr Asp Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly 
            260                 265                 270         


Leu Leu Ser Asn Val Asn Arg Asn Ala Ala Val Glu Leu Thr Arg Arg 
        275                 280                 285             


His Ile Gly Arg Gly Val Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe 
    290                 295                 300                 


Ala Glu Cys Leu Ser Asp Ser Ala Ile Phe Val Gln Ser Pro Asn Cys 
305                 310                 315                 320 


Asn Gln Arg Tyr Gly Trp His Pro Ala Thr Val Cys Lys Ile Pro Pro 
                325                 330                 335     


Gly Cys Asn Leu Lys Ile Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu 
            340                 345                 350         


Ala Gln Ser Val Asn Gln Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg 
        355                 360                 365             


Met Cys Thr Ile Arg Met Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr 
    370                 375                 380                 


Arg Arg Gln Thr Val Thr Ser Thr Pro Cys Trp Ile Glu Leu His Leu 
385                 390                 395                 400 


Asn Gly Pro Leu Gln Trp Leu Asp Lys Val Leu Thr Gln Met Gly Ser 
                405                 410                 415     


Pro Ser Ile Arg Cys Ser Ser Val Ser 
            420                 425 


<210>  239
<211>  1514
<212>  DNA
<213>  homo sapiens

<400>  239
agttctcact gagacctgtc accccgactc aacgtgagac gcaccgcccg gactcaccat       60

gcgtgaatgc atctcagtcc acgtggggca ggcaggtgtc cagatgggca atgcctgctg      120

ggagctctat tgcttggaac atgggattca gcctgatggg cagatgccca gtgacaagac      180

cattggtgga ggggacgact ccttcaccac cttcttctgt gaaactggtg ctggaaaaca      240

cgtaccccgg gcagtttttg tggatctgga gcctacggtc attgatgaga tccgaaatgg      300

cccataccga cagctcttcc acccagagca gctcatcact gggaaagagg atgctgccaa      360

caactatgcc cgtggtcact ataccattgg caaggagatc attgacccag tgctggatcg      420

gatccgcaag ctgtctgacc agtgcacagg acttcagggc ttcctggtgt tccacagctt      480

tggtgggggc actggctctg gcttcacctc actcctgatg gagcggctct ctgttgacta      540

tggcaagaaa tccaagctgg aattctccat ctacccagcc ccccaggtgt ctacagccgt      600

ggtcgagccc tacaactcta tcctgaccac ccacaccacc ctggagcact cagactgtgc      660

cttcatggtg gacaacgaag caatctatga catctgccgc cgcaacctag acatcgagcg      720

cccaacctac accaacctca atcgcctcat tagccaaatt gtctcctcca tcacagcttc      780

tctgcgcttt gacggggccc tcaatgtgga cctgacagag ttccagacca acctggtgcc      840

ctaccctcgc atccacttcc ccctggccac ctatgcacca gtcatctctg cagaaaaggc      900

ataccacgag cagctgtcgg tggcagagat caccaatgcc tgctttgagc ctgccaacca      960

gatggtaaag tgtgatcccc ggcacggcaa gtacatggcc tgctgcctgc tgtaccgtgg     1020

agatgtggtg cccaaggatg tcaacgctgc cattgccgcc atcaagacca agcgcagcat     1080

tcagtttgtg gactggtgcc ccacaggctt caaggttggt atcaactacc agcctcccac     1140

tgtggtgcct gggggtgacc tggccaaggt gcagcgtgcc gtgtgcatgc tgagcaacac     1200

gaccgccatc gccgaggcct gggcccgcct ggaccacaag ttcgacctga tgtatgccaa     1260

gagggcgttt gtgcactggt atgtgggtga gggcatggag gagggtgagt tctccgaggc     1320

ccgtgaggat atggctgccc tggagaagga ttatgaggag gtgggcatcg actcctatga     1380

ggacgaggat gagggagaag aataaagcag ctgcctggag cctattcact atgtttattg     1440

caaaatcctt tcgaaataaa cagtttcctt gcacggttaa aaaaaaaaaa aaaaaaaaaa     1500

aaaaaaaaaa aaaa                                                       1514


<210>  240
<211>  448
<212>  PRT
<213>  homo sapiens

<400>  240

Met Arg Glu Cys Ile Ser Val His Val Gly Gln Ala Gly Val Gln Met 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Thr Thr Phe Phe Cys Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Ile Arg Asn 
65                  70                  75                  80  


Gly Pro Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Pro Val Leu Asp Arg Ile Arg Lys Leu Ser Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Ala Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Ile Asp Ser Tyr Glu Asp Glu Asp Glu Gly Glu Glu 
        435                 440                 445             


<210>  241
<211>  3381
<212>  DNA
<213>  homo sapiens

<400>  241
ataagagctg ggcccggccc acggcggcgg cggcggcggc ggagagagct ggctcagggc       60

gtccgctagg ctcggacgac ctgctgagcc tcccaaaccg cttccataag gctttgcctt      120

tccaacttca gctacagtgt tagctaagtt tggaaagaag gaaaaaagaa aatccctggg      180

ccccttttct tttgttcttt gccaaagtcg tcgttgtagt ctttttgccc aaggctgttg      240

tgtttttaga ggtgctatct ccagttcctt gcactcctgt taacaagcac ctcagcgaga      300

gcagcagcag cgatagcagc cgcagaagag ccagcggggt cgcctagtgt catgaccagg      360

gcgggagatc acaaccgcca gagaggatgc tgtggatcct tggccgacta cctgacctct      420

gcaaaattcc ttctctacct tggtcattct ctctctactt ggggagatcg gatgtggcac      480

tttgcggtgt ctgtgtttct ggtagagctc tatggaaaca gcctcctttt gacagcagtc      540

tacgggctgg tggtggcagg gtctgttctg gtcctgggag ccatcatcgg tgactgggtg      600

gacaagaatg ctagacttaa agtggcccag acctcgctgg tggtacagaa tgtttcagtc      660

atcctgtgtg gaatcatcct gatgatggtt ttcttacata aacatgagct tctgaccatg      720

taccatggat gggttctcac ttcctgctat atcctgatca tcactattgc aaatattgca      780

aatttggcca gtactgctac tgcaatcaca atccaaaggg attggattgt tgttgttgca      840

ggagaagaca gaagcaaact agcaaatatg aatgccacaa tacgaaggat tgaccagtta      900

accaacatct tagcccccat ggctgttggc cagattatga catttggctc cccagtcatc      960

ggctgtggct ttatttcggg atggaacttg gtatccatgt gcgtggagta cgttctgctc     1020

tggaaggttt accagaaaac cccagctcta gctgtgaaag ctggtcttaa agaagaggaa     1080

actgaattga aacagctgaa tttacacaaa gatactgagc caaaacccct ggagggaact     1140

catctaatgg gtgtgaaaga ctctaacatc catgagcttg aacatgagca agagcctact     1200

tgtgcctccc agatggctga gcccttccgt accttccgag atggatgggt ctcctactac     1260

aaccagcctg tgtttctggc tggcatgggt cttgctttcc tttatatgac tgtcctgggc     1320

tttgactgca tcaccacagg gtacgcctac actcagggac tgagtggttc catcctcagt     1380

attttgatgg gagcatcagc tataactgga ataatgggaa ctgtagcttt tacttggcta     1440

cgtcgaaaat gtggtttggt tcggacaggt ctgatctcag gattggcaca gctttcctgt     1500

ttgatcttgt gtgtgatctc tgtattcatg cctggaagcc ccctggactt gtccgtttct     1560

ccttttgaag atatccgatc aaggttcatt caaggagagt caattacacc taccaagata     1620

cctgaaatta caactgaaat atacatgtct aatgggtcta attctgctaa tattgtcccg     1680

gagacaagtc ctgaatctgt gcccataatc tctgtcagtc tgctgtttgc aggcgtcatt     1740

gctgctagaa tcggtctttg gtcctttgat ttaactgtga cacagttgct gcaagaaaat     1800

gtaattgaat ctgaaagagg cattataaat ggtgtacaga actccatgaa ctatcttctt     1860

gatcttctgc atttcatcat ggtcatcctg gctccaaatc ctgaagcttt tggcttgctc     1920

gtattgattt cagtctcctt tgtggcaatg ggccacatta tgtatttccg atttgcccaa     1980

aatactctgg gaaacaagct ctttgcttgc ggtcctgatg caaaagaagt taggaaggaa     2040

aatcaagcaa atacatctgt tgtttgagac agtttaactg ttgctatcct gttactagat     2100

tatatagagc acatgtgctt attttgtact gcagaattcc aataaatggc tgggtgtttt     2160

gctctgtttt taccacagct gtgccttgag aactaaaagc tgtttaggaa acctaagtca     2220

gcagaaatta actgattaat ttcccttatg ttgaggcatg gaaaaaaaat tggaaaagaa     2280

aaactcagtt taaatacgga gactataatg ataacactga attcccctat ttctcatgag     2340

tagatacaat cttacgtaaa agagtggtta gtcacgtgaa ttcagttatc atttgacaga     2400

ttcttatctg tactagaatt cagatatgtc agttttctgc aaaactcact cttgttcaag     2460

actagctaat ttattttttt gcatcttagt tatttttaaa aacaaattct tcaagtatga     2520

agactaaatt ttgataacta atattatcct tattgatcct attgatctta aggtatttac     2580

atgtatgtgg aaaaacaaaa cacttaacta gaattctcta ataaggttta tggtttagct     2640

taaagagcac ctttgtattt ttattatcag atggggcaac atattgtatg aagcatatgt     2700

agcacttcac agcatggtta tcatgtaagc tgcaggtaga agcaaagctg taaagtagat     2760

ttatcacaca atgactgcat acagacttca aatatgtcaa tagtttggtc atagaaccta     2820

gaagccaaaa gccacacaga agggcaagaa tcccaattta actcatgtta tcatcattag     2880

tgatctgtgt tgtagaacat gagggtgtaa gccttcagcc tggcaagtta catgtagaaa     2940

gcccacactt gtgaaggttt tgttttacaa atcacttgat ttaacacact caggtagaat     3000

atttttattt ttactgtttt atacccagaa gttatttcta cattgttcta cagcaagaat     3060

attcataaaa gtatcccttt caaatgcctt tgagaagaat agaagaaaaa aagtttgtat     3120

atattttaaa aaattgtttt aaaagtcagt ttgcaacatg tctgtaccaa gatggtactt     3180

tgccttaacc gtttatatgc actttcatgg agactgcaat acgttgctat gagcactttc     3240

tttatccttg gagtttaatc ctttgcttca tctttctaca gtatgacata atgatttgct     3300

atgttgtaaa atctttgtaa aaaatttcta tataaaaata ttttgaaaat cttaaaaaaa     3360

aaaaaaaaaa aaaaaaaaaa a                                               3381


<210>  242
<211>  571
<212>  PRT
<213>  homo sapiens

<400>  242

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
1               5                   10                  15      


Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
            20                  25                  30          


Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
        35                  40                  45              


Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
    50                  55                  60                  


Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
65                  70                  75                  80  


Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                85                  90                  95      


Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
            100                 105                 110         


Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
        115                 120                 125             


Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
    130                 135                 140                 


Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
145                 150                 155                 160 


Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                165                 170                 175     


Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
            180                 185                 190         


Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
        195                 200                 205             


Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
    210                 215                 220                 


Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
225                 230                 235                 240 


Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                245                 250                 255     


Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
        275                 280                 285             


Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
    290                 295                 300                 


Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
305                 310                 315                 320 


Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                325                 330                 335     


Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
            340                 345                 350         


Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
        355                 360                 365             


Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
    370                 375                 380                 


Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
385                 390                 395                 400 


Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                405                 410                 415     


Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
            420                 425                 430         


Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
        435                 440                 445             


Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
    450                 455                 460                 


Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
465                 470                 475                 480 


Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                485                 490                 495     


Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
            500                 505                 510         


Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
        515                 520                 525             


Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
    530                 535                 540                 


Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
545                 550                 555                 560 


Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                565                 570     


<210>  243
<211>  3620
<212>  DNA
<213>  homo sapiens

<400>  243
agcgccggcg aggcgcggga ggaggagaag cagtggggag gcgcagccgc tcacctgcgg       60

ggcagggcgc ggaggaggga cccgggctgc gcgctctcgg gccgaggaac caggacgcgc      120

ccggagcctc gcacgcggcc aagctcgggg cgtcccctcc cctcggccgg gcgaactcaa      180

ggggcgcagc tctttgcttt gacagagctg gccggcggag gcgtgcagag cggcgagccg      240

gcgagccagg ctgagaaact cgagccggga acaaagaggg gtcggactga gtgtgtgtgt      300

cggctcgagc tccgggcaga ggcatttggg cccgaggccc ccgctgtgac tccccgagac      360

tccgcagtgc cctccactgc ggagtccccg cgcttgccgg caaaaacttt attcttggca      420

aacttctctt tctcttcccc tcctcctcgg cccccatctt ctgctcctcc tccttctcta      480

gcagattaaa tgagcctcga gaagaaaaac cgaagcgaaa gggaagaaaa taagaagatc      540

taaaacggac atctccagcg tgggtggctc ctttttcttt ttcttttttt cccacccttc      600

aggaagtgga cgtttcgtta tcttctgatc cttgcacctt cttttggggc aaacggggcc      660

cttctgccca gatcccctct cttttctcgg aaaacaaact actaagtcgg catccggggt      720

aactacagtg gagagggttt ccgcggagac gcgccgccgg accctcctct gcactttggg      780

gaggcgtgct ccctccagaa ccggcgttct ccgcgcgcaa atcccggcga cgcggggtcg      840

cggggtggcc gccggggcag cctcgtctag cgcgcgccgc gcagacgccc ccggagtcgc      900

cagctaccgc agccctcgcc gcccagtgcc cttcggcctc gggggcgggc gcctgcgtcg      960

gtctccgcga agcgggaaag cgcggcggcc gccgggattc gggcgccgcg gcagctgctc     1020

cggctgccgg ccggcggccc cgcgctcgcc cgccccgctt ccgcccgctg tcctgctgca     1080

cgaacccttc caactctcct ttcctccccc acccttgagt tacccctctg tctttcctgc     1140

tgttgcgcgg gtgctcccac agcggagcgg agattacaga gccgccggga tgccccaact     1200

ctccggagga ggtggcggcg gcggggggga cccggaactc tgcgccacgg acgagatgat     1260

ccccttcaag gacgagggcg atcctcagaa ggaaaagatc ttcgccgaga tcagtcatcc     1320

cgaagaggaa ggcgatttag ctgacatcaa gtcttccttg gtgaacgagt ctgaaatcat     1380

cccggccagc aacggacacg aggtggccag acaagcacaa acctctcagg agccctacca     1440

cgacaaggcc agagaacacc ccgatgacgg aaagcatcca gatggaggcc tctacaacaa     1500

gggaccctcc tactcgagtt attccgggta cataatgatg ccaaatatga ataacgaccc     1560

atacatgtca aatggatctc tttctccacc catcccgaga acatcaaata aagtgcccgt     1620

ggtgcagcca tcccatgcgg tccatcctct cacccccctc atcacttaca gtgacgagca     1680

cttttctcca ggatcacacc cgtcacacat cccatcagat gtcaactcca aacaaggcat     1740

gtccagacat cctccagctc ctgatatccc tactttttat cccttgtctc cgggtggtgt     1800

tggacagatc accccacctc ttggctggca aggtcagcct gtatatccca tcacgggtgg     1860

attcaggcaa ccctacccat cctcactgtc agtcgacact tccatgtcca ggttttccca     1920

tcatatgatt cccggtcctc ctggtcccca cacaactggc atccctcatc cagctattgt     1980

aacacctcag gtcaaacagg aacatcccca cactgacagt gacctaatgc acgtgaagcc     2040

tcagcatgaa cagagaaagg agcaggagcc aaaaagacct cacattaaga agcctctgaa     2100

tgcttttatg ttatacatga aagaaatgag agcgaatgtc gttgctgagt gtactctaaa     2160

agaaagtgca gctatcaacc agattcttgg cagaaggtgg catgccctct cccgtgaaga     2220

gcaggctaaa tattatgaat tagcacggaa agaaagacag ctacatatgc agctttatcc     2280

aggctggtct gcaagagaca attatggtaa gaaaaagaag aggaagagag agaaactaca     2340

ggaatctgca tcaggtacag gtccaagaat gacagctgcc tacatctgaa acatggtgga     2400

aaacgaagct cattcccaac gtgcaaagcc aaggcagcga ccccaggacc tcttctggag     2460

atggaagctt gttgaaaacc cagactgtct ccacggcctg cccagtcgac cccaaaggaa     2520

cactgacatc aattttaccc tgaggtcact gctagagacg ctgatccata aagacaatca     2580

ctgccaaccc ctctttcgtc tactgcaaga gccaagttcc aaaataaagc ataaaaaggt     2640

tttttaaaag gaaatgtaaa agcacatgag aatgctagca ggctgtgggg cagctgagca     2700

gcttttctcc cctcatatct gcgtgcactt cccagagcat cttgcatcca aacctgtaac     2760

ctttcggcaa ggacggtaac ttggctgcat ttgcctgtca tgcgcaactg gagccagcaa     2820

ccagcacatc catcagcacc ccagtggagg agttcatgga agagttccct ctttgtttct     2880

gcttcatttt tctttctttt cttttctcct aaagctttta tttaacagtg caaaaggatc     2940

gttttttttt gcttttttaa acttgaattt ttttaattta cactttttag ttttaatttt     3000

cttgtatatt ttgctagcta tgagctttta aataaaattg aaagttctgg aaaagtttga     3060

aataatgaca taaaaagaag ccttcttttt ctgagacagc ttgtctggta agtggcttct     3120

ctgtgaattg cctgtaacac atagtggctt ctccgccctt gtaaggtgtt cagtagagct     3180

aaataaatgt aatagccaaa cccactctgt tggtagcaat tggcagccct atttcagttt     3240

attttttctt ctgttttctt cttttctttt tttaaacagt aaaccttaac agatgcgttc     3300

agcagactgg tttgcagtga attttcattt ctttccttat cacccccttg ttgtaaaaag     3360

cccagcactt gaattgttat tactttaaat gttctgtatt tgtatctgtt tttattagcc     3420

aattagtggg attttatgcc agttgttaaa atgagcattg atgtacccat tttttaaaaa     3480

agcaaggcac agcctttgcc caaaactgtc atcctaacgt ttgtcattcc agtttgagtt     3540

aatgtgctga gcattttttt aaaagaagct ttgtaataaa acatttttaa aaattgtcat     3600

ttaaaaaaaa aaaaaaaaaa                                                 3620


<210>  244
<211>  399
<212>  PRT
<213>  homo sapiens

<400>  244

Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu 
1               5                   10                  15      


Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro 
            20                  25                  30          


Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly 
        35                  40                  45              


Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile 
    50                  55                  60                  


Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln 
65                  70                  75                  80  


Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His 
                85                  90                  95      


Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser 
            100                 105                 110         


Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn 
        115                 120                 125             


Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val 
    130                 135                 140                 


Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr 
145                 150                 155                 160 


Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser 
                165                 170                 175     


Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp 
            180                 185                 190         


Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr 
        195                 200                 205             


Pro Pro Leu Gly Trp Gln Gly Gln Pro Val Tyr Pro Ile Thr Gly Gly 
    210                 215                 220                 


Phe Arg Gln Pro Tyr Pro Ser Ser Leu Ser Val Asp Thr Ser Met Ser 
225                 230                 235                 240 


Arg Phe Ser His His Met Ile Pro Gly Pro Pro Gly Pro His Thr Thr 
                245                 250                 255     


Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val Lys Gln Glu His 
            260                 265                 270         


Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro Gln His Glu Gln 
        275                 280                 285             


Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys Lys Pro Leu Asn 
    290                 295                 300                 


Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn Val Val Ala Glu 
305                 310                 315                 320 


Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg 
                325                 330                 335     


Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala 
            340                 345                 350         


Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala 
        355                 360                 365             


Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Glu Lys Leu Gln 
    370                 375                 380                 


Glu Ser Ala Ser Gly Thr Gly Pro Arg Met Thr Ala Ala Tyr Ile 
385                 390                 395                 


<210>  245
<211>  1351
<212>  DNA
<213>  homo sapiens

<400>  245
gtgatggaga gcaccagcaa agccttaggg cccatccctg gcctcctgtt acccacagag       60

gggtaggccc ttggctctct tccactatga cgtcagcttc cattcttcct ttcttataga      120

caattttcca tttcaaggaa atcagagccc ttaatagttc agtgaggtca ctttgctgag      180

cacaatccca tacccttcag cctctgctcc acagagccta agcaaaagat agaaactcac      240

aacttccttg ttttgttatc tggaaattat cccaggatct ggtgcttact cagcatattc      300

aaggaaggtc ttacttcatt cttccttgat tgtgaccatg cccaggctct ctgctcccta      360

taaaaggcag gcagagccac cgaggagcag agaggttgag aacaacccag aaaccttcac      420

ctctcatgct gaagctcaca cccttgccct ccaagatgaa ggtttctgca gcgcttctgt      480

gcctgctgct catggcagcc actttcagcc ctcagggact tgctcagcca gattcagttt      540

ccattccaat cacctgctgc tttaacgtga tcaataggaa aattcctatc cagaggctgg      600

agagctacac aagaatcacc aacatccaat gtcccaagga agctgtgatc ttcaagacca      660

aacggggcaa ggaggtctgt gctgacccca aggagagatg ggtcagggat tccatgaagc      720

atctggacca aatatttcaa aatctgaagc catgagcctt catacatgga ctgagagtca      780

gagcttgaag aaaagcttat ttattttccc caacctcccc caggtgcagt gtgacattat      840

tttattataa catccacaaa gagattattt ttaaataatt taaagcataa tatttcttaa      900

aaagtattta attatattta agttgttgat gttttaactc tatctgtcat acatcctagt      960

gaatgtaaaa tgcaaaatcc tggtgatgtg ttttttgttt ttgttttcct gtgagctcaa     1020

ctaagttcac ggcaaaatgt cattgttctc cctcctacct gtctgtagtg ttgtggggtc     1080

ctcccatgga tcatcaaggt gaaacacttt ggtattcttt ggcaatcagt gctcctgtaa     1140

gtcaaatgtg tgctttgtac tgctgttgtt gaaattgatg ttactgtata taactatgga     1200

attttgaaaa aaaatttcaa aaagaaaaaa atatatataa tttaaaacta aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    1351


<210>  246
<211>  99
<212>  PRT
<213>  homo sapiens

<400>  246

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210>  247
<211>  1657
<212>  DNA
<213>  homo sapiens

<400>  247
gctcacagga agccacgcac ccttgaaagg caccgggtcc ttcttagcat cgtgcttcct       60

gagcaagcct ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg      120

cttctggttg ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg      180

gatatagcag acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt      240

atccccaagc cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca      300

ctgtattcct tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg      360

ttcaaataca agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg      420

gatctgctct tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt      480

tttgggctag gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc      540

atattctttg tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt      600

tccttgaggg caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg      660

gctgtgttcg cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat      720

acctactgca aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg      780

gaaatcaaca ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg      840

atcatcagga ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc      900

tttgccgtgg tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta      960

gagaccctgg tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat     1020

gccatccagg ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac     1080

ttttttctgg gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc     1140

ctttttgtgc tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc     1200

tcatcttaca cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa     1260

atggtgaaat gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt     1320

agtaagagat tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc     1380

ttctcatcct gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc     1440

acctgggctg aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat     1500

gagaactctg agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc     1560

ccttctaacc tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag     1620

taaatcgcta ccttttgctg tggcaaatgg gccctct                              1657


<210>  248
<211>  360
<212>  PRT
<213>  homo sapiens

<400>  248

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  249
<211>  4287
<212>  DNA
<213>  homo sapiens

<400>  249
agagtaactg ctgaaaggag gtggcgaagg aggatccgga gcagctgctg ccagcccgcg       60

ggcactgaag tcctcccggc tgccgctcga gtagccacgg gcgcgatcgg gaccagaagt      120

ctcctcctcc atgatcactt tggaagccgg gggaagactt tgccctgccc tgagagctgg      180

tctgcgtttc ccaggcgcgg cggcggcgga gcagcagctg cagcagccga gtccaaatag      240

gagcggccac agccaggggc gtgagcgccc cgcgcggagc gagctcgggt tcccctcgga      300

atgtccccgg ggcgcccggc gcgctgaccc cgaagccgcc tccgccttcg gcgcctgctg      360

cctccctcgg ccaggcttgt tgttcgggac tgtgagcttc ctggctcctg ggcagtgggg      420

aagcccccgg gggcgagtga cctcagctgg ccacgaccca gccctccccc gtgcgtatct      480

cgcttaagat ggcagcggag tcaggggaac taatcggggc ttgtgagttc atgaaagatc      540

ggttatattt tgctacttta aggaatagac caaaaagcac agtaaatacc cactatttct      600

ccatcgatga ggagctggtc tatgaaaatt tctatgcaga ttttggaccg ctgaacttgg      660

caatggtgta cagatattgc tgcaaactaa acaagaaact aaaatcatac agtttgtcaa      720

gaaagaaaat agtgcactac acctgttttg accaacggaa aagagcaaat gcagcatttt      780

tgataggtgc ctatgcagta atctatttaa agaagacacc agaagaagcc tacagagcac      840

tcctgtctgg ctcaaacccc ccctatcttc cattcaggga tgcttccttt ggaaattgca      900

cttacaatct caccattctc gactgtttgc agggaatcag aaagggatta caacatggat      960

tttttgactt tgagacattt gatgtggatg aatatgaaca ttatgagcga gttgaaaatg     1020

gtgacttcaa ctggattgtt ccaggaaaat ttttagcatt tagtggacca catcctaaaa     1080

gcaaaattga gaatggttat cctcttcacg cccctgaagc ctactttcct tatttcaaaa     1140

agcataatgt gactgcagtt gtgaggctaa acaaaaagat ttatgaggca aagcgcttca     1200

cagacgctgg cttcgagcac tatgacctct tcttcataga tggcagcaca cccagtgaca     1260

acatcgtgcg aaggttcctg aacatctgtg agaacaccga aggggccatc gccgttcact     1320

gcaaagctgg tcttggaaga acagggacat tgatagcctg ttatgtaatg aaacactaca     1380

ggtttacaca tgctgaaata attgcttgga ttagaatatg ccggccaggc tctattatag     1440

gaccccagca gcacttcctg gaagaaaaac aagcatcgtt gtgggtccaa ggagacattt     1500

tccgatccaa actgaaaaat cgaccatcca gtgaaggaag tattaataaa attctttctg     1560

gcctagatga tatgtctatt ggtggaaatc tttcaaaaac acaaaacatg gaacgatttg     1620

gagaggataa cttagaagat gatgatgtgg aaatgaaaaa tggtataacc cagggagaca     1680

aactacgtgc cttaaaaagt cagagacagc cacgtacctc accatcctgt gcatttaggt     1740

cagatgatac aaaaggacat ccaagagcag tgtcccagcc tttcagatta agttcatccc     1800

tgcaaggatc tgcagttact ttgaagacat caaaaatggc actgtcccct tcagcaacgg     1860

ccaagaggat caacagaact tctttgtctt cgggtgccac tgtaagaagc ttttccataa     1920

actcccggct agccagttct ctagggaact tgaatgctgc aacagatgat ccagagaaca     1980

aaaagacctc ctcatcctct aaggcaggct tcacagccag cccgtttacc aacctcttga     2040

atggcagctc ccagccaact accagaaatt accctgagct caacaataat cagtacaaca     2100

gaagcagcaa cagcaacggg ggcaacctga acagcccccc aggcccccac agcgccaaga     2160

cagaggagca caccaccatc ctccgaccct cctacaccgg gctttcttct tcttcagcga     2220

gattcctgag ccgttctatc ccttcccttc agtctgaata tgttcattac taaggccttg     2280

ccactccagt gaaagctgtt cttctcttag acacaatttc ttcatctgga cgagcagtgg     2340

agagggaaag caacttcttg ctggaagaat atctctgcct tcttacctta aattaaaaag     2400

agcactaaga taacaccttc aagagacttg aaaacagaaa actggttaat gactactata     2460

aatgcactga aactatgttt atggagattt ccatactttt aaagacagtt ttaatgttga     2520

atttggtatt ttgaagggtt atttttaatg tattttggta atacatttat tattatattt     2580

acatgtacag tgttacatta tatatgtatt gtgaacttta aaagactatt ttgataaatt     2640

tataaatata taaaattatg taaaaactac actatatttt gatttagatt ttcctgctgt     2700

ttgctaccaa aaatttgtat tttaaatctg tttagtttta gtatggtttt gtctctaatg     2760

aataaataat tccttcttat taagaagaag taagggagaa agtttttaga aagtgatttt     2820

tatgctcgca ctataaatat ggcaggtcag ttcattcttt tgggaagtca gtttagttac     2880

actgagttta tccaagttta tctctaccaa gagtataatg gcatgggatg gcttatttag     2940

gacaattccc tttcctattg tttttgttgc tgagccaatt tgagttagtt ttgcatcctg     3000

gggggcttta aaatacagca tgcagtgaaa gatcagaatt cactgaatat ttcttctgag     3060

agcatggttt catggttttt ctctatgaaa tgactcaata ttccaaatgt ttttttttcc     3120

ttcctccttt caaaagagtt cttaacccaa ttaggatatc ctgctttggg tatgaggttg     3180

ttgttgcctg taatcacaca tggtttgaca tcagttttaa atcaatggag agaaaaaact     3240

gaaaaagatg ctgctaagta gttctctgta ttaaaggaga tatttttaaa acagggtaca     3300

accccctgct gcacacgcta gcatatctgg aacctactat gaaaatgaaa ggacccttat     3360

aggtactcac agccctttca tgtaagtatg atctgatatt taggtcttca gaagcctgta     3420

ggtttcattt ctatgaggaa tcgaggagcg ttacatcctg atatccttcc aggctgctta     3480

agaatggact gcttcgacac tgaaagtgct agttaaatgg attcatatga agtgctttac     3540

tcccaaccat tgagttattt ataatgtatt tattagggga gggtaccttg agtctattat     3600

atatgcttca tcaaaacatc ttgttcatgt tttatgtttt taaaaaaggc atttgaatga     3660

atgtttgact caggtttgtt aaattaacct tcagtaactg cagtaccaaa aattacactc     3720

aactgatgaa aaaaacgaat tgtatgattt aggaatcaaa aactaaaata agtggaatta     3780

tgtatctttt ctaaagttaa aaaagtaaaa tattttatta tgagttatta taaaaattgg     3840

ttaattgtat aggaagatga cagtattttt ttcaagttat cataaaaagt aattcagatg     3900

acatttgaga agtaggggaa agggaatcat gttgacagtt ttagttctgt gaacactaat     3960

ttgtgtgaag ctattaaaat gattgtaaag ttgactactg taaatttccc ataattatgt     4020

gtgtatatgt gtcatatgta tgtacatgta tatgtctaaa aattacttta cacatgtgcc     4080

tacatagaca caccaagaag tggatgtata taatatagaa agtatatagc aaagtaattt     4140

tactctgata ataaaaattg tttgacatgt attttgttat gaatagttta tcttccaaaa     4200

gatattttgc tctattttaa agtgtagaag aatacactgc taataaataa taaaagtttt     4260

attcaattta aaaaaaaaaa aaaaaaa                                         4287


<210>  250
<211>  594
<212>  PRT
<213>  homo sapiens

<400>  250

Met Ala Ala Glu Ser Gly Glu Leu Ile Gly Ala Cys Glu Phe Met Lys 
1               5                   10                  15      


Asp Arg Leu Tyr Phe Ala Thr Leu Arg Asn Arg Pro Lys Ser Thr Val 
            20                  25                  30          


Asn Thr His Tyr Phe Ser Ile Asp Glu Glu Leu Val Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu Ser Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys Lys Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro Pro Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn Leu Thr Ile Leu 
    130                 135                 140                 


Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His Gly Phe Phe Asp 
145                 150                 155                 160 


Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr Glu Arg Val Glu 
                165                 170                 175     


Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe Leu Ala Phe Ser 
            180                 185                 190         


Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr Pro Leu His Ala 
        195                 200                 205             


Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn Val Thr Ala Val 
    210                 215                 220                 


Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg Phe Thr Asp Ala 
225                 230                 235                 240 


Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly Ser Thr Pro Ser 
                245                 250                 255     


Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu Asn Thr Glu Gly 
            260                 265                 270         


Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu 
        275                 280                 285             


Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr His Ala Glu Ile 
    290                 295                 300                 


Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile Ile Gly Pro Gln 
305                 310                 315                 320 


Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp Val Gln Gly Asp 
                325                 330                 335     


Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser Glu Gly Ser Ile 
            340                 345                 350         


Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile Gly Gly Asn Leu 
        355                 360                 365             


Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Asp Asn Leu Glu Asp 
    370                 375                 380                 


Asp Asp Val Glu Met Lys Asn Gly Ile Thr Gln Gly Asp Lys Leu Arg 
385                 390                 395                 400 


Ala Leu Lys Ser Gln Arg Gln Pro Arg Thr Ser Pro Ser Cys Ala Phe 
                405                 410                 415     


Arg Ser Asp Asp Thr Lys Gly His Pro Arg Ala Val Ser Gln Pro Phe 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Gln Gly Ser Ala Val Thr Leu Lys Thr Ser 
        435                 440                 445             


Lys Met Ala Leu Ser Pro Ser Ala Thr Ala Lys Arg Ile Asn Arg Thr 
    450                 455                 460                 


Ser Leu Ser Ser Gly Ala Thr Val Arg Ser Phe Ser Ile Asn Ser Arg 
465                 470                 475                 480 


Leu Ala Ser Ser Leu Gly Asn Leu Asn Ala Ala Thr Asp Asp Pro Glu 
                485                 490                 495     


Asn Lys Lys Thr Ser Ser Ser Ser Lys Ala Gly Phe Thr Ala Ser Pro 
            500                 505                 510         


Phe Thr Asn Leu Leu Asn Gly Ser Ser Gln Pro Thr Thr Arg Asn Tyr 
        515                 520                 525             


Pro Glu Leu Asn Asn Asn Gln Tyr Asn Arg Ser Ser Asn Ser Asn Gly 
    530                 535                 540                 


Gly Asn Leu Asn Ser Pro Pro Gly Pro His Ser Ala Lys Thr Glu Glu 
545                 550                 555                 560 


His Thr Thr Ile Leu Arg Pro Ser Tyr Thr Gly Leu Ser Ser Ser Ser 
                565                 570                 575     


Ala Arg Phe Leu Ser Arg Ser Ile Pro Ser Leu Gln Ser Glu Tyr Val 
            580                 585                 590         


His Tyr 
        


<210>  251
<211>  3286
<212>  DNA
<213>  Homo Sapiens

<400>  251
ccgccagtcc ccgcgcagtc cccgcgcagt ccccgcgcag tcccagcgcc accgggcagc       60

agcggcgccg tgctcgctcc agggcgcaac catgtcgcca tttcttcgga ttggcttgtc      120

caactttgac tgcgggtcct gccagtcttg tcagggcgag gctgttaacc cttactgtgc      180

tgtgctcgtc aaagagtatg tcgaatcaga gaacgggcag atgtatatcc agaaaaagcc      240

taccatgtac ccaccctggg acagcacttt tgatgcccat atcaacaagg gaagagtcat      300

gcagatcatt gtgaaaggca aaaacgtgga cctcatctct gaaaccaccg tggagctcta      360

ctcgctggct gagaggtgca ggaagaacaa cgggaagaca gaaatatggt tagagctgaa      420

acctcaaggc cgaatgctaa tgaatgcaag atactttctg gaaatgagtg acacaaagga      480

catgaatgaa tttgagacgg aaggcttctt tgctttgcat cagcgccggg gtgccatcaa      540

gcaggcaaag gtccaccacg tcaagtgcca cgagttcact gccaccttct tcccacagcc      600

cacattttgc tctgtctgcc acgagtttgt ctggggcctg aacaaacagg gctaccagtg      660

ccgacaatgc aatgcagcaa ttcacaagaa gtgtattgat aaagttatag caaagtgcac      720

aggatcagct atcaatagcc gagaaaccat gttccacaag gagagattca aaattgacat      780

gccacacaga tttaaagtct acaattacaa gagcccgacc ttctgtgaac actgtgggac      840

cctgctgtgg ggactggcac ggcaaggact caagtgtgat gcatgtggca tgaatgtgca      900

tcatagatgc cagacaaagg tggccaacct ttgtggcata aaccagaagc taatggctga      960

agcgctggcc atgattgaga gcactcaaca ggctcgctgc ttaagagata ctgaacagat     1020

cttcagagaa ggtccggttg aaattggtct cccatgctcc atcaaaaatg aagcaaggcc     1080

gccatgttta ccgacaccgg gaaaaagaga gcctcagggc atttcctggg agtctccgtt     1140

ggatgaggtg gataaaatgt gccatcttcc agaacctgaa ctgaacaaag aaagaccatc     1200

tctgcagatt aaactaaaaa ttgaggattt tatcttgcac aaaatgttgg ggaaaggaag     1260

ttttggcaag gtcttcctgg cagaattcaa gaaaaccaat caatttttcg caataaaggc     1320

cttaaagaaa gatgtggtct tgatggacga tgatgttgag tgcacgatgg tagagaagag     1380

agttctttcc ttggcctggg agcatccgtt tctgacgcac atgttttgta cattccagac     1440

caaggaaaac ctcttttttg tgatggagta cctcaacgga ggggacttaa tgtaccacat     1500

ccaaagctgc cacaagttcg acctttccag agcgacgttt tatgctgctg aaatcattct     1560

tggtctgcag ttccttcatt ccaaaggaat agtctacagg gacctgaagc tagataacat     1620

cctgttagac aaagatggac atatcaagat cgcggatttt ggaatgtgca aggagaacat     1680

gttaggagat gccaagacga ataccttctg tgggacacct gactacatcg ccccagagat     1740

cttgctgggt cagaaataca accactctgt ggactggtgg tccttcgggg ttctccttta     1800

tgaaatgctg attggtcagt cgcctttcca cgggcaggat gaggaggagc tcttccactc     1860

catccgcatg gacaatccct tttacccacg gtggctggag aaggaagcaa aggaccttct     1920

ggtgaagctc ttcgtgcgag aacctgagaa gaggctgggc gtgaggggag acatccgcca     1980

gcaccctttg tttcgggaga tcaactggga ggaacttgaa cggaaggaga ttgacccacc     2040

gttccggccg aaagtgaaat caccatttga ctgcagcaat ttcgacaaag aattcttaaa     2100

cgagaagccc cggctgtcat ttgccgacag agcactgatc aacagcatgg accagaatat     2160

gttcaggaac ttttccttca tgaaccccgg gatggagcgg ctgatatcct gaatcttgcc     2220

cctccagaga caggaaagaa tttgccttct ccctgggaac tggttcaaga gacactgctt     2280

gggttccttt ttcaacttgg aaaaagaaag aaacactcaa caataaagac tgagacccgt     2340

tcgcccccat gtgactttta tctgtagcag aaaccaagtc tacttcacta atgacgatgc     2400

cgtgtgtctc gtctcctgac atgtctcaca gacgctcctg aagttaggtc attactaacc     2460

atagttattt acttgaaaga tgggtctccg cacttggaaa ggtttcaaga cttgatactg     2520

caataaatta tggctcttca cctgggcgcc aactgctgat caatgaaatg cttgttgaat     2580

caggggcaaa cggagtacag acgtctcaag actgaaacgg ccccattgcc tggtctagta     2640

gcggatctca ctcagccgca gacaagtaat cactaacccg ttttattcta ttcctatctg     2700

tggatgtgta aatggctggg gggccagccc tggataggtt tttatgggaa ttctttacaa     2760

taaacatagc ttgtaacttg agatctacaa atccattcat cctgattggg catgaaatcc     2820

atggtcaaga ggacaagtgg aaagtgagag ggaaggtttg ctagacacct tcgcttgtta     2880

tcttgtcaag atagaaaaga tagtatcatt tcacccttgc cagtaaaaac ctttccatcc     2940

acccattctc agcagactcc agtattggca cagtcactca ctgccattct cacactataa     3000

caagaaaaga aatgaagtgc ataagtctcc tgggaaaaga accttaaccc cttctcgtgc     3060

catgactggt gatttcatga ctcataagcc cctccgtagg catcattcaa gatcaatggc     3120

ccatgcatgc tgtttgcagc agtcaattga gttgaattag aattccaacc atacatttta     3180

aaggtatttg tgctgtgtgt atattttgat aaaatgttgt gacttcatgg caaacaggtg     3240

gatgtgtaaa aatggaataa aaaaaaaaaa agagtcaaaa aaaaaa                    3286


<210>  252
<211>  706
<212>  PRT
<213>  Homo Sapiens

<400>  252

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15      


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30          


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45              


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60                  


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80  


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95      


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110         


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125             


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140                 


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160 


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175     


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190         


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205             


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220                 


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240 


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255     


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270         


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285             


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300                 


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320 


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335     


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350         


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu Arg 
        355                 360                 365             


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380                 


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415     


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430         


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445             


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460                 


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480 


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495     


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510         


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525             


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540                 


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560 


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575     


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590         


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605             


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620                 


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640 


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655     


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670         


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685             


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700                 


Ile Ser 
705     


<210>  253
<211>  3288
<212>  DNA
<213>  Homo Sapiens

<400>  253
gctccctccc ctcctagctg gcttcggcgg ggacggcggc ggcggcggcg ggcggggagg       60

gcgtgcgccg gccgagaggt gtcggcggcg aggcaaagga agtttcaagt ggaaggtcgt      120

ccgtcggccg gcgcgtcctc ctgctctcct ccgcagcatc atggcggagc cgagcggctc      180

gcccgtgcac gtccagcttc cccagcaggc ggccccggtg acagcggcgg cggcggcggc      240

cccggcggcc gcgacagcag cgccggcccc ggcagctccc gcggccccgg ccccggcccc      300

ggccccggcg gcacaggctg tcggctggcc catctgcagg gacgcgtacg agctgcagga      360

ggttatcggc agtggagcta ctgctgtggt tcaggcagcc ctatgcaaac ccaggcaaga      420

acgtgtagca ataaaacgga tcaacttgga aaaatgccag accagtatgg atgaactatt      480

aaaagaaatt caagccatga gtcagtgcag ccatcccaac gtagtgacct attacacctc      540

ttttgtggtc aaagatgaac tttggctggt catgaaatta ctaagtggag gttcaatgtt      600

ggatatcata aaatacattg tcaaccgagg agaacacaag aatggagttc tggaagaggc      660

aataatagca acaattctta aagaggtttt ggaaggctta gactatctac acagaaacgg      720

tcagattcac agggatttga aagctggtaa tattcttctg ggtgaggatg gttcagtaca      780

aatagcagat tttggggtaa gtgcgttcct agcaacaggg ggtgatgtta cccgaaataa      840

agtaagaaaa acattcgttg gcaccccatg ttggatggct cctgaagtca tggaacaggt      900

gagaggctat gacttcaagg ctgacatgtg gagttttgga ataactgcca ttgaattagc      960

aacaggagca gcgccttatc acaaatatcc tcccatgaaa gtgttaatgt tgactttgca     1020

aaatgatcca cccactttgg aaacaggggt agaggataaa gaaatgatga aaaagtacgg     1080

caagtccttt agaaaattac tttcactgtg tcttcagaaa gatccttcca aaaggcccac     1140

agcagcagaa cttttaaaat gcaaattctt ccagaaagcc aagaacagag agtacctgat     1200

tgagaagctg cttacaagaa caccagacat agcccaaaga gccaaaaagg taagaagagt     1260

tcctgggtca agtggtcacc ttcataaaac cgaagacggg gactgggagt ggagtgacga     1320

cgagatggat gagaagagcg aagaagggaa agcagctttt tctcaggaaa agtcacgaag     1380

agtaaaagaa gaaaatccag agattgcagt gagtgccagc accatccccg aacaaataca     1440

gtccctctct gtgcacgact ctcagggccc acccaatgct aatgaagact acagagaagc     1500

ttcttcttgt gccgtgaacc tcgttttgag attaagaaac tccagaaagg aacttaatga     1560

catacgattt gagtttactc caggaagaga tacagcagat ggtgtatctc aggagctctt     1620

ctctgctggc ttggtggatg gtcacgatgt agttatagtg gctgctaatt tacagaagat     1680

tgtagatgat cccaaagctt taaaaacatt gacatttaag ttggcttctg gctgtgatgg     1740

gtcggagatt cctgatgaag tgaagctgat tgggtttgct cagttgagtg tcagctgatg     1800

tatgtccctt gatgtcaccc tgatctgtca tgccccaccg ccacccctac tcccttcaac     1860

cctccctctt tctgcccatt tcctcccacc ccctcactcc catttcctag caaaatcaga     1920

agattgtgaa gaggccggct tcaacaaaat gggataaaaa aataattttt taaaacttac     1980

aacactccga gttctgcttt attctctagc aatccacagt acaagaacaa gcaaatgcca     2040

cagctgcacg actgttgctc atttttccaa aagctattta atattcttag caatcaattt     2100

ggatatccct taagtgaaaa gaatctgaaa tacactcagg tggtcttatt tattggcaac     2160

aaaaggaatt ttctatccag aagcctattt ctcctttcat tgttgttatt tctgttataa     2220

tactttaatt gtacatctga caatactgcc tcttttatgt tgtatttaga aattaatata     2280

cttataaaat taagatttat tagccaaact tgaattctag ttttaaaact gactgtgaat     2340

tttatttttc atatatttat gcattacaca ccttagctat aagaaaaaaa gggttttgat     2400

tatatgcttc ttgcagttaa tctcgttatt taaacaaaaa gttttgggtc tgtctttgga     2460

gtatttgtaa cttctaaatt ttgaaatgac tgaattagga atttggatgc ttattctttt     2520

agtctgtttg cctaaaaacc aatttacaat ctgactgtct cttgggagag ggaggtgcct     2580

tgcaaacttt cacattaaga atgtgcctga ggctgcttta ctctggaata gtctcagatc     2640

taaaatttcc tctatataag gtggcatatg ttaagttttg cttcattgga ccgtttagaa     2700

tgctatgtaa aatgttgcca ttctgttaga ttgctaacta tatacccatc tctgatttgg     2760

ctctccttaa gtgataggat ttgttattct aaaggtgata aacttgaaaa tatcagaatc     2820

tgagttttac ttgaaatttt gcagaatacc caggtggagt gaaaattgga agggttttgt     2880

gcaatgacta aaaggtaaaa cgctgttaag gttcaagaat caatactttc aacccaagta     2940

gccctctgct tgactgtata ttatggaact agtaaacctt aggattttga aaattggagt     3000

ctaatctttc aaggaggtgg gctcccagga tggtaccatt gctctttcct agctaaccct     3060

agatatggca gctctttaat gtacttcaaa aagcaaatat atattactaa ggaaaaaaag     3120

ttatttataa ttgccttgtc ataattgtta aggtgttcta gagccatttg catacaattt     3180

aatgtaattt cattccattc tattgtttac acaacgatta ctcgaagatg actgcaaagg     3240

taaaaggaaa ataaaagtgt attgcacaat gagaaaaaaa aaaaaaaa                  3288


<210>  254
<211>  545
<212>  PRT
<213>  Homo Sapiens

<400>  254

Met Ala Glu Pro Ser Gly Ser Pro Val His Val Gln Leu Pro Gln Gln 
1               5                   10                  15      


Ala Ala Pro Val Thr Ala Ala Ala Ala Ala Ala Pro Ala Ala Ala Thr 
            20                  25                  30          


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Ala Gln Ala Val Gly Trp Pro Ile Cys Arg Asp Ala Tyr Glu 
    50                  55                  60                  


Leu Gln Glu Val Ile Gly Ser Gly Ala Thr Ala Val Val Gln Ala Ala 
65                  70                  75                  80  


Leu Cys Lys Pro Arg Gln Glu Arg Val Ala Ile Lys Arg Ile Asn Leu 
                85                  90                  95      


Glu Lys Cys Gln Thr Ser Met Asp Glu Leu Leu Lys Glu Ile Gln Ala 
            100                 105                 110         


Met Ser Gln Cys Ser His Pro Asn Val Val Thr Tyr Tyr Thr Ser Phe 
        115                 120                 125             


Val Val Lys Asp Glu Leu Trp Leu Val Met Lys Leu Leu Ser Gly Gly 
    130                 135                 140                 


Ser Met Leu Asp Ile Ile Lys Tyr Ile Val Asn Arg Gly Glu His Lys 
145                 150                 155                 160 


Asn Gly Val Leu Glu Glu Ala Ile Ile Ala Thr Ile Leu Lys Glu Val 
                165                 170                 175     


Leu Glu Gly Leu Asp Tyr Leu His Arg Asn Gly Gln Ile His Arg Asp 
            180                 185                 190         


Leu Lys Ala Gly Asn Ile Leu Leu Gly Glu Asp Gly Ser Val Gln Ile 
        195                 200                 205             


Ala Asp Phe Gly Val Ser Ala Phe Leu Ala Thr Gly Gly Asp Val Thr 
    210                 215                 220                 


Arg Asn Lys Val Arg Lys Thr Phe Val Gly Thr Pro Cys Trp Met Ala 
225                 230                 235                 240 


Pro Glu Val Met Glu Gln Val Arg Gly Tyr Asp Phe Lys Ala Asp Met 
                245                 250                 255     


Trp Ser Phe Gly Ile Thr Ala Ile Glu Leu Ala Thr Gly Ala Ala Pro 
            260                 265                 270         


Tyr His Lys Tyr Pro Pro Met Lys Val Leu Met Leu Thr Leu Gln Asn 
        275                 280                 285             


Asp Pro Pro Thr Leu Glu Thr Gly Val Glu Asp Lys Glu Met Met Lys 
    290                 295                 300                 


Lys Tyr Gly Lys Ser Phe Arg Lys Leu Leu Ser Leu Cys Leu Gln Lys 
305                 310                 315                 320 


Asp Pro Ser Lys Arg Pro Thr Ala Ala Glu Leu Leu Lys Cys Lys Phe 
                325                 330                 335     


Phe Gln Lys Ala Lys Asn Arg Glu Tyr Leu Ile Glu Lys Leu Leu Thr 
            340                 345                 350         


Arg Thr Pro Asp Ile Ala Gln Arg Ala Lys Lys Val Arg Arg Val Pro 
        355                 360                 365             


Gly Ser Ser Gly His Leu His Lys Thr Glu Asp Gly Asp Trp Glu Trp 
    370                 375                 380                 


Ser Asp Asp Glu Met Asp Glu Lys Ser Glu Glu Gly Lys Ala Ala Phe 
385                 390                 395                 400 


Ser Gln Glu Lys Ser Arg Arg Val Lys Glu Glu Asn Pro Glu Ile Ala 
                405                 410                 415     


Val Ser Ala Ser Thr Ile Pro Glu Gln Ile Gln Ser Leu Ser Val His 
            420                 425                 430         


Asp Ser Gln Gly Pro Pro Asn Ala Asn Glu Asp Tyr Arg Glu Ala Ser 
        435                 440                 445             


Ser Cys Ala Val Asn Leu Val Leu Arg Leu Arg Asn Ser Arg Lys Glu 
    450                 455                 460                 


Leu Asn Asp Ile Arg Phe Glu Phe Thr Pro Gly Arg Asp Thr Ala Asp 
465                 470                 475                 480 


Gly Val Ser Gln Glu Leu Phe Ser Ala Gly Leu Val Asp Gly His Asp 
                485                 490                 495     


Val Val Ile Val Ala Ala Asn Leu Gln Lys Ile Val Asp Asp Pro Lys 
            500                 505                 510         


Ala Leu Lys Thr Leu Thr Phe Lys Leu Ala Ser Gly Cys Asp Gly Ser 
        515                 520                 525             


Glu Ile Pro Asp Glu Val Lys Leu Ile Gly Phe Ala Gln Leu Ser Val 
    530                 535                 540                 


Ser 
545 


<210>  255
<211>  3871
<212>  DNA
<213>  Homo Sapiens

<400>  255
ctgcagcctc cgcagaggcg attggctgaa gctaccggcc gcgtggggcg ggactcggtt       60

gccagggagc ggcgcgggag ccctgagggg actgcggcgg ctgcgcggag gagcgaggca      120

cttgctgggg tcggggctgc gcgacggcgc aggggctgcg gggagcgccg cgcaggccgt      180

gcagttccta gcgaggaggc gccgccgcca ttgccgctct ctcggtgagc gcagccccgc      240

tctccgggcc gggccttcgc gggccaccgg cgccatgggc cagtgcggca tcacctcctc      300

caagaccgtg ctggtctttc tcaacctcat cttctggggg gcagctggca ttttatgcta      360

tgtgggagcc tatgtcttca tcacttatga tgactatgac cacttctttg aagatgtgta      420

cacgctcatc cctgctgtag tgatcatagc tgtaggagcc ctgcttttca tcattgggct      480

aattggctgc tgtgccacaa tccgggaaag tcgctgtgga cttgccacgt ttgtcatcat      540

cctgctcttg gtttttgtca cagaagttgt tgtagtggtt ttgggatatg tttacagagc      600

aaaggtggaa aatgaggttg atcgcagcat tcagaaagtg tataagacct acaatggaac      660

caaccctgat gctgctagcc gggctattga ttatgtacag agacagctgc attgttgtgg      720

aattcacaac tactcagact gggaaaatac agattggttc aaagaaacca aaaaccagag      780

tgtccctctt agctgctgca gagagactgc cagcaattgt aatggcagcc tggcccaccc      840

ttccgacctc tatgctgagg ggtgtgaggc tctagtagtg aagaagctac aagaaatcat      900

gatgcatgtg atctgggccg cactggcatt tgcagctatt cagctgctgg gcatgctgtg      960

tgcttgcatc gtgttgtgca gaaggagtag agatcctgct tacgagctcc tcatcactgg     1020

cggaacctat gcatagttga caactcaagc ctgagctttt tggtcttgtt ctgatttgga     1080

aggtgaattg agcaggtctg ctgctgttgg cctctggagt tcatttagtt aaagcacatg     1140

tacactggtg ttggacagag cagcttggct tttcatgtgc ccacctactt acctactacc     1200

tgcgactttc tttttccttg ttctagctga ctcttcatgc ccctaagatt ttaagtacga     1260

tggtgaacgt tctaatttca gaaccaattg cgagtcatgt agtgtggtag aattaaagga     1320

ggacacgagc ctgcttctgt tacctccaag tggtaacagg actgatgccg aaatgtcacc     1380

aggtcctttc agtcttcaca gtggagaact cttggccaaa ggtttttgcg gggaggagga     1440

ggaaaccagc tttctggtta aggttaacac cagatggtgc ccctcattgg tgtcctttta     1500

aaaaatattt actgtagtcc aataagatag cagctgtaca aaatgactaa aatagattgt     1560

aggatcatat ggcgtatatc ttggttcatc ttcaaaatca gagactgagc tttgaaacta     1620

gtggttttta atcaaagttg gctttatagg aggagtataa tgtatgcact actgttttaa     1680

aagaattagt gtgagtgtgt ttttgtatga atgagcccat tcatggtaag tcttaagctt     1740

gttggaaata atgtacccat gtagactagc aaaatagtat gtagatgtga tctcagttgt     1800

aaatagaaaa atctaattca ataaactctg tatcagcccc caacatatta tttttcatta     1860

tttgggggat atttcagttc cagagcagca gtatcatgtt ttctttgttg gtgctgtcta     1920

tagttcatca tggtttacgt gtgttttcgt tatagctgtt gccagattct aaagggcttg     1980

atattcaaaa aaccacagat gctttcagtc cagtatatcc tagaaatata gagctctact     2040

ttgtgcaatg cactggggat acagtggcga tactgtcctt gtcttcaagg agttcggagt     2100

cctagtatag gagacataca taggagaaga taattttcac actgcagtgg ttgtagtaat     2160

agaatgggag tccaaagggg agttccggag aggtcagggg tgacttcctg gaggagatgc     2220

ccaagcttgg aggctggata ggctttgttg aaagatggta cacaagagtg tgaaacaaaa     2280

ttgtgtgtgc agggagctta aaatacaagg ctggggaaag aagttggaga agcaggaaag     2340

cccaggccct ctagtgtctt acggaacatc ctgtggaggt gagagctgac ttgtaggtgg     2400

aagcagctct ttggaggttt gatttggaag gtgaactgag aagaaggtgg tgatgcaagc     2460

cggccgtgct gaagccagga tgaattggtg tgactgggct tcagttaggc tggcatagca     2520

gttgagagag cttagcagtg ggcagcaggg cactgttggg ggcggtggtg agcggtggat     2580

tctggctgtt tggaggcagg acagtggtgg aattcgatca ttgattggac gtgggacaga     2640

gaagggagaa gagaagactc atctaggatg agtcccaggt ttctggctca gtcaactggg     2700

gaaacaaagt cacagagcta gggagtagtt agagaacaca tctgggggtg tgactcatgg     2760

tcagttttgg gctcgtcagt tttgagatgc ccaaatatca tgcagatctg tcccacctga     2820

aaatggagaa gacacgggaa aggagaggag taaaaactaa ctccttttca caaagtggaa     2880

gttaccagaa tgtgatttca gaggccccgg gggatttatc atgtgactac tgacccatcc     2940

cacctcttgc ccctgcctgt tgcacagtgg gcaagaatgt ttgtgacctt tcactaccac     3000

cacctccccc gagcatggtc cccccagttt tcaatatgaa ccatcctgtg ggtaccctgt     3060

cacaggctgg ccctgaggtg agcaatattt ggactgtgat gttggttgtt ctccactctt     3120

tctacaggac agaacagggc ctctagagtg ggaaatggct ttgggaaata tgccaagcag     3180

tagccttgtt cttcaacttg cccaagagga taattctcca cacccttcct gtactcagtc     3240

ctcagtttgc ctggtgagag agcagcctcc tcccgtgtgc tctgccagct ggacccagac     3300

tggccatatt accagtgaga ccaaaaagat ggaggtgggg aggtagctct gaggtctggg     3360

aaaccattcc agctcctgcc agttttaact tgtgtttaat tcctggcaca gttgtcctgg     3420

aaatgccttt ttctcttgcc tgggaaccac tagaagggga tgttgtctgt gttggccagg     3480

gccatgcaaa ttcaacatct tgtttctgcc cttcccccgt gtagctgagg ctaggtgttg     3540

gcattaccca gtgcttgttc ttcagagagc aaaagcactg ctcgtcatgt ctgaaattta     3600

gtgagtgagc tcacccacta ggctggtgtt tcctgcccgt ggctgcacat tggaagcacc     3660

ggggcacttt gagaactaca gatgcctggg tcccagagca tctaaggtgc tctagggtgt     3720

gtccaggaca cagccctggt tgaggaccac tgctatattg tatggcctct tttaaaaaag     3780

ttaattttac ttggaaatga tttcaaagct acagaaaagt tgcaagaata aaaactgtac     3840

aaatgaggct caaaaaaaaa aaaaaaaaaa a                                    3871


<210>  256
<211>  253
<212>  PRT
<213>  Homo Sapiens

<400>  256

Met Gly Gln Cys Gly Ile Thr Ser Ser Lys Thr Val Leu Val Phe Leu 
1               5                   10                  15      


Asn Leu Ile Phe Trp Gly Ala Ala Gly Ile Leu Cys Tyr Val Gly Ala 
            20                  25                  30          


Tyr Val Phe Ile Thr Tyr Asp Asp Tyr Asp His Phe Phe Glu Asp Val 
        35                  40                  45              


Tyr Thr Leu Ile Pro Ala Val Val Ile Ile Ala Val Gly Ala Leu Leu 
    50                  55                  60                  


Phe Ile Ile Gly Leu Ile Gly Cys Cys Ala Thr Ile Arg Glu Ser Arg 
65                  70                  75                  80  


Cys Gly Leu Ala Thr Phe Val Ile Ile Leu Leu Leu Val Phe Val Thr 
                85                  90                  95      


Glu Val Val Val Val Val Leu Gly Tyr Val Tyr Arg Ala Lys Val Glu 
            100                 105                 110         


Asn Glu Val Asp Arg Ser Ile Gln Lys Val Tyr Lys Thr Tyr Asn Gly 
        115                 120                 125             


Thr Asn Pro Asp Ala Ala Ser Arg Ala Ile Asp Tyr Val Gln Arg Gln 
    130                 135                 140                 


Leu His Cys Cys Gly Ile His Asn Tyr Ser Asp Trp Glu Asn Thr Asp 
145                 150                 155                 160 


Trp Phe Lys Glu Thr Lys Asn Gln Ser Val Pro Leu Ser Cys Cys Arg 
                165                 170                 175     


Glu Thr Ala Ser Asn Cys Asn Gly Ser Leu Ala His Pro Ser Asp Leu 
            180                 185                 190         


Tyr Ala Glu Gly Cys Glu Ala Leu Val Val Lys Lys Leu Gln Glu Ile 
        195                 200                 205             


Met Met His Val Ile Trp Ala Ala Leu Ala Phe Ala Ala Ile Gln Leu 
    210                 215                 220                 


Leu Gly Met Leu Cys Ala Cys Ile Val Leu Cys Arg Arg Ser Arg Asp 
225                 230                 235                 240 


Pro Ala Tyr Glu Leu Leu Ile Thr Gly Gly Thr Tyr Ala 
                245                 250             


<210>  257
<211>  7573
<212>  DNA
<213>  Homo Sapiens

<400>  257
gcggaacgtg ggctcgcgcg ccccgccttt gtctcccggg cgcgagccgc cgcagccccg       60

cgcccgctgc tcgctgcgga gccgttttgt gccgcggcgc gggggaacgg ggacgcgggg      120

cggggggcgc ggagccggcg ggcgcagcct cagcatggac gtgacagtct cggagctcct      180

ggagctcttc ctgcagagcc cgctggtgac ctgggtgaaa acttttggcc cgtttggaag      240

cggcagccag gacaacctga ctatgtacat ggatttagtg gacggcatct ttttgaacca      300

aattatgctg caaatagatc ccaggcccac aaatcaacgc atcaataagc acgtcaacaa      360

tgatgtgaac cttcgcattc agaatttgac catcttggtg agaaacatta agacctacta      420

ccaggaagtt ctccagcagc tgattgtaat gaatttgccc aatgttttga tgattggcag      480

agacccactg tctgggaaga gcatggagga aatcaagaag gtgctgctgc tggtgctggg      540

ctgtgctgtc cagtgtgaga ggaaagagga gttcattgaa agaatcaaac agctggacat      600

tgagacccag gctggcatcg tggcccatat ccaggaggtg actcacaacc aagagaacgt      660

gtttgacctg cagtggctgg agctgcccga cgtggctccg gaggagctgg aggccctgtc      720

gaggagcatg gtgctccacc tgcggaggct catcgaccag cgggacgagt gcaccgagct      780

gatcgtggac ctcactcagg aacgggacta cctgcaggca cagcatccac ccagccccat      840

caagtcctcc agcgccgact ccactcccag ccccaccagc agcctctcta gcgaagacaa      900

gcagcacctg gccgtagagc tggccgacac caaggccagg ctgcggcgcg tcaggcagga      960

gctggaggat aagacagagc agcttgtgga caccagacat gaggtggacc agctggtgct     1020

ggaactgcag aaagttaagc aggagaacat ccagctagcg gcagacgccc ggtctgctcg     1080

tgcctatcga gacgagctgg attccctgcg ggagaaggcg aaccgcgtgg agaggctgga     1140

gctggagctg acccgctgca aggagaagct gcacgacgtg gacttctaca aggcccgcat     1200

ggaggagctg agagaagata atatcatttt aattgaaacc aaggccatgc tggaggaaca     1260

gctgactgct gctcgggccc ggggcgataa agtccatgag ctggaaaagg agaacctgca     1320

gctgaaatcc aagcttcacg acctggaatt ggaccgggac acagataaga aacgaattga     1380

ggagctgctg gaagaaaaca tggtccttga gattgcacag aagcagagca tgaacgaatc     1440

tgcccacctt ggctgggagc tggagcagct gtccaagaac gcagacttgt cagacgcctc     1500

caggaagtcg tttgtgtttg agctgaacga atgtgcgtcc agccgcatcc tgaagctgga     1560

gaaggagaat cagagcctcc agagcaccat ccaggggctg cgggacgcgt ccctggtgtt     1620

ggaggagagc ggcctcaagt gcggggagct ggagaaggag aaccaccagc tcagcaagaa     1680

gattgaaaag ttacaaaccc agctggagag agaaaagcag agcaaccaag atctggagac     1740

cctcagtgag gagctgatca gagagaagga gcagctgcag agtgacatgg agaccctgaa     1800

ggctgacaaa gccaggcaga tcaaggacct tgagcaggaa aaggaccacc tcaaccgagc     1860

catgtggtcg ctgcgggaga ggtcgcaggt cagcagtgag gcccgcatga aagacgtgga     1920

gaaggagaac aaagccctcc accagacggt gacggaggcc aatggcaagc tcagccagtt     1980

ggagtttgag aagcggcagc tgcacaggga cttggagcag gccaaggaga agggggagcg     2040

ggcagagaag ctggagaggg agctacagcg actccaggag gagaacggga ggctggccag     2100

gaaggtgacc tccctggaga cagccaccga gaaagtcgag gccctggagc atgagagcca     2160

gggcctgcag ctggagaacc ggactctgag gaagtctctg gacaccttgc agaacgtgtc     2220

cctgcagctt gagggcctgg agcgtgacaa caagcagctg gacgcagaga acctggagct     2280

gcgcaggctg gtggagacca tgcgcttcac cagcaccaag ctggcacaga tggagaggga     2340

gaaccagcag ctggagcgtg agaaggagga gctgaggaag aacgtggatc tgctcaaggc     2400

gctgggcaag aagtcagagc gcctggagct cagctaccag agcgtgagcg ctgagaacct     2460

ccggctgcag cagagcctgg agagcagcag ccacaagacg cagaccttgg agagtgagct     2520

gggcgagctg gaggctgagc gccaggcgct gcggcgggac ctggaggccc tccggctggc     2580

caatgcacag ttggaggggg ccgagaagga caggaaggcc ctggagcagg aggtggccca     2640

gctcgagaag gataagaagc tgctggagaa ggaggccaag cggctgtggc agcaggtgga     2700

gctcaaggat gcagtcttgg acgatagcac tgccaaactg tccgccgttg agaaggagag     2760

ccgcgcgctg gacaaggagc tggcccgctg cagggacgca gccggcaagc tgaaggagct     2820

ggagaaggac aaccgggacc tcaccaagca agtcaccgtg catgcaagga cactgacaac     2880

tctgagggag gacctggtgc tcgagaagct gaagagccag cagctcagca gtgagctgga     2940

caagctgagc caggaactgg agaaggtcgg cctcaacagg gagctgctgt tgcaggagga     3000

cgacagcggc agtgacacaa aatacaagat tttggagggc agaaatgaat cagcattaaa     3060

aacaacacta gccatgaaag aagaaaagat tgtgctctta gaagcacaga tggaagagaa     3120

agcgagccta aatcgccagt tagagagtga gctgcagatg ctaaagaagg agtgtgagac     3180

cctcaggcag aaccagggag aggggcagca cttgcagaac tctttcaagc accctgcggg     3240

gaagacagcc gccagtcacc aggggaagga ggcctggggg cccggccata aggaagccac     3300

catggagctt ctccgagtga aggaccgggc catcgagctg gagcggaata atgcagctct     3360

gcaggctgag aagcagctgc taaaggaaca gctgcagcac ctggagaccc agaacgtgac     3420

cttcagcagc cagatcttga cactgcagaa acagagcgcc ttcctgcagg agcacaacac     3480

cacactgcag acccagaccg ccaagctgca ggtggagaac tccacgctga gttcccagag     3540

cgcagcgctc accgcgcagt acacgctgct gcagaaccac cacacggcca aggagacgga     3600

gaacgaaagc ctgcagaggc agcaggagca acttacagcg gcctacgagg ccctgctgca     3660

ggaccacgag cacctgggca cgctgcacga gcggcaatcg gccgagtacg aggccctcat     3720

ccgccagcac agctgcctaa agacactgca tcggaatctg gagctggagc acaaggagct     3780

cggggagagg cacggtgaca tgctgaagcg caaggcggag ctggaggagc gggagaaggt     3840

cttgaccact gagcgagagg cgctgcagca ggagcagagg acaaacgccc tcgccatggg     3900

cgagaaccag aggctgcggg gcgagctgga cagggtcaat ttcctgcacc accagctgaa     3960

gggggagtac gaggagctgc acgcccacac caaggagctg aaaacctcac tgaacaacgc     4020

gcagctggag ctcaaccgct ggcaggcccg cttcgacgag ctgaaggagc agcaccagac     4080

catggacatc tcgctgacca agctggacaa ccactgtgag ctgctctccc gtctcaaggg     4140

gaacttggag gaagaaaatc atcacctcct gagccagatc cagctgttga gccagcagaa     4200

ccagatgctt ctggagcaga acatggagaa caaggagcag taccatgagg agcagaagca     4260

gtacatagac aaattaaatg ccttacgaag acataaggaa aagctggaag aaaaaatcat     4320

ggatcaatac aagttctatg atcctcctcc aaagaagaag aaccactgga ttggagccaa     4380

agccttagtc aaactcatca aaccaaagaa agagggttcg agggaacgct taaaatccac     4440

cgtggacagc cctccctggc agctggagtc ctcagacccc gcctcgccgg cggcctctca     4500

gccgctcaga tcacaggccg agaaccccga cacccccgca ctgggctcca actgtgcaga     4560

agagcgcgac gcccacaacg ggtctgtggg gaaaggccct ggggatctaa aaccaaagcg     4620

aggctcccca cacagaggca gccttgaccg cacagatgcc tccaccgatc tggccatgag     4680

gtcctggccc tcggagctgg gctcccggac ttgctcaact tcagccacca ctacagcccc     4740

ttccaactcc acccccatcg cccggcaccc aggccgcacc aaaggctata actcagatga     4800

caacctctgt gagccatccc tggagtttga ggtccccaac cacaggcagt acgtgtcgcg     4860

gccaagtagc ttagagagca gtagaaacac atccagcaac agctcacctc ttaacctaaa     4920

aggctcctcc gagcagctcc atggccggtc tgagagcttc agcagcgaag acctgatccc     4980

cagcagggac ctggccactt tgccccggga agccagcaca ccgggacgca acgccctcgg     5040

ccgccacgag taccccttgc ctcggaacgg gcctctccca caggagggtg cccagaagag     5100

gggcacagcc cctccctacg tcggagtgcg gccctgctcg gcctccccca gcagtgagat     5160

ggtcaccttg gaggagttcc tggaggagag caaccgcagc tcccccaccc atgacactcc     5220

cagttgccgg gatgacctgc tgagtgacta cttccgaaag gccagcgatc ccccagccat     5280

cggaggccaa ccaggaccac ctgccaagaa agaaggggcc aagatgccca ccaactttgt     5340

ggcccccacc gtcaaaatgg ccgcccccac ctcggagggg aggccgctga agcccgggca     5400

gtacgtaaag ccaaacttca gactgactga ggccgaggcc ccacccagcg tggccccgag     5460

acaggcccag cctccccaga gcctgtctct gggcagaccc cggcaggctc cggtgccccc     5520

agcttcccat gcacctgcca gccgcagtgc ctccttgagc cgggccttca gcctggcctc     5580

agctgacctt ctccgggcca gcgggccaga ggcctgcaaa caggagtccc ctcagaagct     5640

gggggctcct gaggccttag ggggcagaga gacaggcagc cacaccctgc aaagccccgc     5700

accccccagc tcccatagcc tggcccggga gcggacccca cttgtgggaa aggctggcag     5760

ctcctgtcag ggcccaggtc cccgcagccg gccgctggac acgaggcgct tctccctggc     5820

tcccccaaag gaggagaggc tggcccccct gcatcagtct gccacagccc ccgccattgc     5880

cactgcaggt gctggtgctg ctgctgctgg cagtggcagc aactcccagc tcctgcactt     5940

ctcacctgct gcagccccgg ctgccaggac caagcccaag gcgcccccac gctcagggga     6000

ggtggccacc atcacccctg tccgggcagg gctcagcctc tcagagggag acggggtccc     6060

ggggcagggc tgcagtgagg ggcttccggc caagagccca ggtcggtctc ccgatttggc     6120

tccccacctc ggccgggccc tggaggactg cagtcgaggg agcgtctcaa agagcagtcc     6180

ggcctccccg gagcccggcg gggatccgca gaccgtgtgg tatgagtacg gctgtgtgtg     6240

actgtctcgt ggttgagctc gcaaacctga aaactactga cgcgccttcc gactctcacg     6300

gccttttctc ttgcttgcct gcggtgccag gagagggttt ggaatgagga aaggggttcc     6360

cacgcatttc tgctgtttgt tctgtgaatg gaaacactgt gccaagcccc aagaggatta     6420

cgcttccagg tgtgtaacgt gttttctgtg tctgccgctt ccagcagctg atatctttgg     6480

aacaaataat ccacgtcagc atggggacca attaggatgc aatgacaaac tgacttcccc     6540

caaagcagac actactccag tatgtcccag tagaacactc atttgcaatg tgttgagctc     6600

cgttaagcac acacacactc acacaacagg cttacgaggc tcaggcctgg cgggtcagaa     6660

agcccactcc ctctcccaag gccactggat cccaggagaa gcccagactg gcgatactac     6720

aaaggtctcc agggcctggc agaccccaga gtcaggcctg ctgttaaaaa gtgagagtgc     6780

tgctgttcca ttcctggggt cccaagcact tccctttacc ccaggaccca gggcagcctg     6840

cagggcagct ggcggtggcc ttggccattt gcccccagcc tccagctggc tcctgagctc     6900

tgcaccaggg ggtttgggga ccacacaggc acctgccttc ctagatttcc ctggctcact     6960

tttctgcaaa cactggatct gccaggcctg gggattgggg ggcaggaaag aggcccccat     7020

ccagccccct ccaggccagt gtgcacagtg caccgagggg tcatccgcac agagcgaggt     7080

gcaagctcga tgtgtaacct ggctgcggca cccgacatcc ccggtctcgg ggtgttgatt     7140

tatttctgaa taactttttg ggtatagaaa ccaatttttt ttaatatatg acatgtatat     7200

gtacacactc atgtgaaata tgtatacttt ggggggatct atttatgttc cagtgggagt     7260

cactctcttc tgtcgggaat cttatctgct gctttgtgtc tttggtcaga ttcctgacaa     7320

tttagtttcc tgttgtaaag gtgcttttcc tggggtgaac taaacctatt gatttttttt     7380

ttttaagatt tttttttcct tttgatttaa tatactgaga aagaaatggg agacttttga     7440

atgttaacaa gatccatttt aggagtgttt ggggttgtgt attaaatagc cattcattct     7500

ggaactcaag gacaggactg taataaaatg gaatggaacc gaaaaaaaaa aaaaaaaaaa     7560

aaaaaaaaaa aaa                                                        7573


<210>  258
<211>  2028
<212>  PRT
<213>  Homo Sapiens

<400>  258

Met Asp Val Thr Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Thr Trp Val Lys Thr Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Thr Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Thr Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Thr Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Thr Tyr Tyr Gln Glu Val Leu Gln Gln Leu 
                85                  90                  95      


Ile Val Met Asn Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu 
            100                 105                 110         


Ser Gly Lys Ser Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu 
        115                 120                 125             


Gly Cys Ala Val Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile 
    130                 135                 140                 


Lys Gln Leu Asp Ile Glu Thr Gln Ala Gly Ile Val Ala His Ile Gln 
145                 150                 155                 160 


Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu 
                165                 170                 175     


Leu Pro Asp Val Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met 
            180                 185                 190         


Val Leu His Leu Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Thr Glu 
        195                 200                 205             


Leu Ile Val Asp Leu Thr Gln Glu Arg Asp Tyr Leu Gln Ala Gln His 
    210                 215                 220                 


Pro Pro Ser Pro Ile Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro 
225                 230                 235                 240 


Thr Ser Ser Leu Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu 
                245                 250                 255     


Ala Asp Thr Lys Ala Arg Leu Arg Arg Val Arg Gln Glu Leu Glu Asp 
            260                 265                 270         


Lys Thr Glu Gln Leu Val Asp Thr Arg His Glu Val Asp Gln Leu Val 
        275                 280                 285             


Leu Glu Leu Gln Lys Val Lys Gln Glu Asn Ile Gln Leu Ala Ala Asp 
    290                 295                 300                 


Ala Arg Ser Ala Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu 
305                 310                 315                 320 


Lys Ala Asn Arg Val Glu Arg Leu Glu Leu Glu Leu Thr Arg Cys Lys 
                325                 330                 335     


Glu Lys Leu His Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu 
            340                 345                 350         


Arg Glu Asp Asn Ile Ile Leu Ile Glu Thr Lys Ala Met Leu Glu Glu 
        355                 360                 365             


Gln Leu Thr Ala Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu 
    370                 375                 380                 


Lys Glu Asn Leu Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp 
385                 390                 395                 400 


Arg Asp Thr Asp Lys Lys Arg Ile Glu Glu Leu Leu Glu Glu Asn Met 
                405                 410                 415     


Val Leu Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu 
            420                 425                 430         


Gly Trp Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala 
        435                 440                 445             


Ser Arg Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg 
    450                 455                 460                 


Ile Leu Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Thr Ile Gln 
465                 470                 475                 480 


Gly Leu Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys 
                485                 490                 495     


Gly Glu Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys 
            500                 505                 510         


Leu Gln Thr Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu 
        515                 520                 525             


Thr Leu Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp 
    530                 535                 540                 


Met Glu Thr Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu 
545                 550                 555                 560 


Gln Glu Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg 
                565                 570                 575     


Ser Gln Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn 
            580                 585                 590         


Lys Ala Leu His Gln Thr Val Thr Glu Ala Asn Gly Lys Leu Ser Gln 
        595                 600                 605             


Leu Glu Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys 
    610                 615                 620                 


Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu 
625                 630                 635                 640 


Gln Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Thr Ser Leu Glu Thr 
                645                 650                 655     


Ala Thr Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln 
            660                 665                 670         


Leu Glu Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr Leu Gln Asn Val 
        675                 680                 685             


Ser Leu Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala 
    690                 695                 700                 


Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Thr Met Arg Phe Thr Ser 
705                 710                 715                 720 


Thr Lys Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu 
                725                 730                 735     


Lys Glu Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys 
            740                 745                 750         


Lys Ser Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn 
        755                 760                 765             


Leu Arg Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Thr Gln Thr 
    770                 775                 780                 


Leu Glu Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg 
785                 790                 795                 800 


Arg Asp Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala 
                805                 810                 815     


Glu Lys Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys 
            820                 825                 830         


Asp Lys Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val 
        835                 840                 845             


Glu Leu Lys Asp Ala Val Leu Asp Asp Ser Thr Ala Lys Leu Ser Ala 
    850                 855                 860                 


Val Glu Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg 
865                 870                 875                 880 


Asp Ala Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu 
                885                 890                 895     


Thr Lys Gln Val Thr Val His Ala Arg Thr Leu Thr Thr Leu Arg Glu 
            900                 905                 910         


Asp Leu Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu 
        915                 920                 925             


Asp Lys Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu 
    930                 935                 940                 


Leu Leu Gln Glu Asp Asp Ser Gly Ser Asp Thr Lys Tyr Lys Ile Leu 
945                 950                 955                 960 


Glu Gly Arg Asn Glu Ser Ala Leu Lys Thr Thr Leu Ala Met Lys Glu 
                965                 970                 975     


Glu Lys Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu 
            980                 985                 990         


Asn Arg Gln Leu Glu Ser Glu Leu  Gln Met Leu Lys Lys  Glu Cys Glu 
        995                 1000                 1005             


Thr Leu  Arg Gln Asn Gln Gly  Glu Gly Gln His Leu  Gln Asn Ser 
    1010                 1015                 1020             


Phe Lys  His Pro Ala Gly Lys  Thr Ala Ala Ser His  Gln Gly Lys 
    1025                 1030                 1035             


Glu Ala  Trp Gly Pro Gly His  Lys Glu Ala Thr Met  Glu Leu Leu 
    1040                 1045                 1050             


Arg Val  Lys Asp Arg Ala Ile  Glu Leu Glu Arg Asn  Asn Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ala Glu Lys Gln Leu  Leu Lys Glu Gln Leu  Gln His Leu 
    1070                 1075                 1080             


Glu Thr  Gln Asn Val Thr Phe  Ser Ser Gln Ile Leu  Thr Leu Gln 
    1085                 1090                 1095             


Lys Gln  Ser Ala Phe Leu Gln  Glu His Asn Thr Thr  Leu Gln Thr 
    1100                 1105                 1110             


Gln Thr  Ala Lys Leu Gln Val  Glu Asn Ser Thr Leu  Ser Ser Gln 
    1115                 1120                 1125             


Ser Ala  Ala Leu Thr Ala Gln  Tyr Thr Leu Leu Gln  Asn His His 
    1130                 1135                 1140             


Thr Ala  Lys Glu Thr Glu Asn  Glu Ser Leu Gln Arg  Gln Gln Glu 
    1145                 1150                 1155             


Gln Leu  Thr Ala Ala Tyr Glu  Ala Leu Leu Gln Asp  His Glu His 
    1160                 1165                 1170             


Leu Gly  Thr Leu His Glu Arg  Gln Ser Ala Glu Tyr  Glu Ala Leu 
    1175                 1180                 1185             


Ile Arg  Gln His Ser Cys Leu  Lys Thr Leu His Arg  Asn Leu Glu 
    1190                 1195                 1200             


Leu Glu  His Lys Glu Leu Gly  Glu Arg His Gly Asp  Met Leu Lys 
    1205                 1210                 1215             


Arg Lys  Ala Glu Leu Glu Glu  Arg Glu Lys Val Leu  Thr Thr Glu 
    1220                 1225                 1230             


Arg Glu  Ala Leu Gln Gln Glu  Gln Arg Thr Asn Ala  Leu Ala Met 
    1235                 1240                 1245             


Gly Glu  Asn Gln Arg Leu Arg  Gly Glu Leu Asp Arg  Val Asn Phe 
    1250                 1255                 1260             


Leu His  His Gln Leu Lys Gly  Glu Tyr Glu Glu Leu  His Ala His 
    1265                 1270                 1275             


Thr Lys  Glu Leu Lys Thr Ser  Leu Asn Asn Ala Gln  Leu Glu Leu 
    1280                 1285                 1290             


Asn Arg  Trp Gln Ala Arg Phe  Asp Glu Leu Lys Glu  Gln His Gln 
    1295                 1300                 1305             


Thr Met  Asp Ile Ser Leu Thr  Lys Leu Asp Asn His  Cys Glu Leu 
    1310                 1315                 1320             


Leu Ser  Arg Leu Lys Gly Asn  Leu Glu Glu Glu Asn  His His Leu 
    1325                 1330                 1335             


Leu Ser  Gln Ile Gln Leu Leu  Ser Gln Gln Asn Gln  Met Leu Leu 
    1340                 1345                 1350             


Glu Gln  Asn Met Glu Asn Lys  Glu Gln Tyr His Glu  Glu Gln Lys 
    1355                 1360                 1365             


Gln Tyr  Ile Asp Lys Leu Asn  Ala Leu Arg Arg His  Lys Glu Lys 
    1370                 1375                 1380             


Leu Glu  Glu Lys Ile Met Asp  Gln Tyr Lys Phe Tyr  Asp Pro Pro 
    1385                 1390                 1395             


Pro Lys  Lys Lys Asn His Trp  Ile Gly Ala Lys Ala  Leu Val Lys 
    1400                 1405                 1410             


Leu Ile  Lys Pro Lys Lys Glu  Gly Ser Arg Glu Arg  Leu Lys Ser 
    1415                 1420                 1425             


Thr Val  Asp Ser Pro Pro Trp  Gln Leu Glu Ser Ser  Asp Pro Ala 
    1430                 1435                 1440             


Ser Pro  Ala Ala Ser Gln Pro  Leu Arg Ser Gln Ala  Glu Asn Pro 
    1445                 1450                 1455             


Asp Thr  Pro Ala Leu Gly Ser  Asn Cys Ala Glu Glu  Arg Asp Ala 
    1460                 1465                 1470             


His Asn  Gly Ser Val Gly Lys  Gly Pro Gly Asp Leu  Lys Pro Lys 
    1475                 1480                 1485             


Arg Gly  Ser Pro His Arg Gly  Ser Leu Asp Arg Thr  Asp Ala Ser 
    1490                 1495                 1500             


Thr Asp  Leu Ala Met Arg Ser  Trp Pro Ser Glu Leu  Gly Ser Arg 
    1505                 1510                 1515             


Thr Cys  Ser Thr Ser Ala Thr  Thr Thr Ala Pro Ser  Asn Ser Thr 
    1520                 1525                 1530             


Pro Ile  Ala Arg His Pro Gly  Arg Thr Lys Gly Tyr  Asn Ser Asp 
    1535                 1540                 1545             


Asp Asn  Leu Cys Glu Pro Ser  Leu Glu Phe Glu Val  Pro Asn His 
    1550                 1555                 1560             


Arg Gln  Tyr Val Ser Arg Pro  Ser Ser Leu Glu Ser  Ser Arg Asn 
    1565                 1570                 1575             


Thr Ser  Ser Asn Ser Ser Pro  Leu Asn Leu Lys Gly  Ser Ser Glu 
    1580                 1585                 1590             


Gln Leu  His Gly Arg Ser Glu  Ser Phe Ser Ser Glu  Asp Leu Ile 
    1595                 1600                 1605             


Pro Ser  Arg Asp Leu Ala Thr  Leu Pro Arg Glu Ala  Ser Thr Pro 
    1610                 1615                 1620             


Gly Arg  Asn Ala Leu Gly Arg  His Glu Tyr Pro Leu  Pro Arg Asn 
    1625                 1630                 1635             


Gly Pro  Leu Pro Gln Glu Gly  Ala Gln Lys Arg Gly  Thr Ala Pro 
    1640                 1645                 1650             


Pro Tyr  Val Gly Val Arg Pro  Cys Ser Ala Ser Pro  Ser Ser Glu 
    1655                 1660                 1665             


Met Val  Thr Leu Glu Glu Phe  Leu Glu Glu Ser Asn  Arg Ser Ser 
    1670                 1675                 1680             


Pro Thr  His Asp Thr Pro Ser  Cys Arg Asp Asp Leu  Leu Ser Asp 
    1685                 1690                 1695             


Tyr Phe  Arg Lys Ala Ser Asp  Pro Pro Ala Ile Gly  Gly Gln Pro 
    1700                 1705                 1710             


Gly Pro  Pro Ala Lys Lys Glu  Gly Ala Lys Met Pro  Thr Asn Phe 
    1715                 1720                 1725             


Val Ala  Pro Thr Val Lys Met  Ala Ala Pro Thr Ser  Glu Gly Arg 
    1730                 1735                 1740             


Pro Leu  Lys Pro Gly Gln Tyr  Val Lys Pro Asn Phe  Arg Leu Thr 
    1745                 1750                 1755             


Glu Ala  Glu Ala Pro Pro Ser  Val Ala Pro Arg Gln  Ala Gln Pro 
    1760                 1765                 1770             


Pro Gln  Ser Leu Ser Leu Gly  Arg Pro Arg Gln Ala  Pro Val Pro 
    1775                 1780                 1785             


Pro Ala  Ser His Ala Pro Ala  Ser Arg Ser Ala Ser  Leu Ser Arg 
    1790                 1795                 1800             


Ala Phe  Ser Leu Ala Ser Ala  Asp Leu Leu Arg Ala  Ser Gly Pro 
    1805                 1810                 1815             


Glu Ala  Cys Lys Gln Glu Ser  Pro Gln Lys Leu Gly  Ala Pro Glu 
    1820                 1825                 1830             


Ala Leu  Gly Gly Arg Glu Thr  Gly Ser His Thr Leu  Gln Ser Pro 
    1835                 1840                 1845             


Ala Pro  Pro Ser Ser His Ser  Leu Ala Arg Glu Arg  Thr Pro Leu 
    1850                 1855                 1860             


Val Gly  Lys Ala Gly Ser Ser  Cys Gln Gly Pro Gly  Pro Arg Ser 
    1865                 1870                 1875             


Arg Pro  Leu Asp Thr Arg Arg  Phe Ser Leu Ala Pro  Pro Lys Glu 
    1880                 1885                 1890             


Glu Arg  Leu Ala Pro Leu His  Gln Ser Ala Thr Ala  Pro Ala Ile 
    1895                 1900                 1905             


Ala Thr  Ala Gly Ala Gly Ala  Ala Ala Ala Gly Ser  Gly Ser Asn 
    1910                 1915                 1920             


Ser Gln  Leu Leu His Phe Ser  Pro Ala Ala Ala Pro  Ala Ala Arg 
    1925                 1930                 1935             


Thr Lys  Pro Lys Ala Pro Pro  Arg Ser Gly Glu Val  Ala Thr Ile 
    1940                 1945                 1950             


Thr Pro  Val Arg Ala Gly Leu  Ser Leu Ser Glu Gly  Asp Gly Val 
    1955                 1960                 1965             


Pro Gly  Gln Gly Cys Ser Glu  Gly Leu Pro Ala Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Asp Leu Ala Pro  His Leu Gly Arg Ala  Leu Glu Asp 
    1985                 1990                 1995             


Cys Ser  Arg Gly Ser Val Ser  Lys Ser Ser Pro Ala  Ser Pro Glu 
    2000                 2005                 2010             


Pro Gly  Gly Asp Pro Gln Thr  Val Trp Tyr Glu Tyr  Gly Cys Val 
    2015                 2020                 2025             


<210>  259
<211>  8240
<212>  DNA
<213>  Homo Sapiens

<400>  259
cccctctcgg tagccctgag gctctggcgc cttcaagtga gaagctaagc accagcctct       60

gctgggctgc agaagcggcg gcggcggcag cagcagcagc agcatcagga aggcgctcgg      120

gccagcgcgg tgaacccggg ctgggcagca ggtcgcggag ccgcgagcca ggatggaggc      180

agagggcagc agcgcgccgg cccgggcggg cagcggagag ggcagcgaca gcgccggcgg      240

ggccacgctc aaagccccca agcatctctg gaggcacgag cagcaccacc agtacccgct      300

ccggcagccc cagttccgcc tcctgcatcc ccatcaccac ctgcccccgc cgccgccacc      360

ctcgccccag ccccagcccc agtgtccgct acagccgccg ccgccgcccc ccctgccgcc      420

gcccccgccg ccgcccgggg ctgcccgcgg ccgctacgcc tcgagcgggg ccaccggccg      480

cgtccggcat cgcggctact cggacaccga gcgctacctg tactgtcgcg ccatggaccg      540

cacctcctac gcggtggaga ccggccaccg gcccggcctg aagaaatcca ggatgtcctg      600

gccctcctcg ttccagggac tcaggcgttt tgatgtggac aatggcacat ctgcgggacg      660

gagtcccttg gatcccatga ccagcccagg atccgggcta attctccaag caaattttgt      720

ccacagtcaa cgacgggagt ccttcctgta tcgatccgac agcgattatg acctctctcc      780

aaagtctatg tcccggaact cctccattgc cagtgatata cacggagatg acttgattgt      840

gactccattt gctcaggtct tggccagtct gcgaactgta cgaaacaact ttgctgcatt      900

aactaatttg caagatcgag cacctagcaa aagatcaccc atgtgcaacc aaccatccat      960

caacaaagcc accataacag aggaggccta ccagaaactg gccagcgaga ccctggagga     1020

gctggactgg tgtctggacc agctagagac cctacagacc aggcactccg tcagtgagat     1080

ggcctccaac aagtttaaaa ggatgcttaa tcgggagctc acccatctct ctgaaatgag     1140

tcggtctgga aatcaagtgt cagagtttat atcaaacaca ttcttagata agcaacatga     1200

agtggaaatt ccttctccaa ctcagaagga aaaggagaaa aagaaaagac caatgtctca     1260

gatcagtgga gtcaagaaat tgatgcacag ctctagtctg actaattcaa gtatcccaag     1320

gtttggagtt aaaactgaac aagaagatgt ccttgccaag gaactagaag atgtgaacaa     1380

atggggtctt catgttttca gaatagcaga gttgtctggt aaccggccct tgactgttat     1440

catgcacacc atttttcagg aacgggattt attaaaaaca tttaaaattc cagtagatac     1500

tttaattaca tatcttatga ctctcgaaga ccattaccat gctgatgtgg cctatcacaa     1560

caatatccat gctgcagatg ttgtccagtc tactcatgtg ctattatcta cacctgcttt     1620

ggaggctgtg tttacagatt tggagattct tgcagcaatt tttgccagtg caatacatga     1680

tgtagatcat cctggtgtgt ccaatcaatt tctgatcaat acaaactctg aacttgcctt     1740

gatgtacaat gattcctcag tcttagagaa ccatcatttg gctgtgggct ttaaattgct     1800

tcaggaagaa aactgtgaca ttttccagaa tttgaccaaa aaacaaagac aatctttaag     1860

gaaaatggtc attgacatcg tacttgcaac agatatgtca aaacacatga atctactggc     1920

tgatttgaag actatggttg aaactaagaa agtgacaagc tctggagttc ttcttcttga     1980

taattattcc gataggattc aggttcttca gaatatggtg cactgtgcag atctgagcaa     2040

cccaacaaag cctctccagc tgtaccgcca gtggacggac cggataatgg aggagttctt     2100

ccgccaagga gaccgagaga gggaacgtgg catggagata agccccatgt gtgacaagca     2160

caatgcttcc gtggaaaaat cacaggtggg cttcatagac tatattgttc atcccctctg     2220

ggagacatgg gcagacctcg tccaccctga cgcccaggat attttggaca ctttggagga     2280

caatcgtgaa tggtaccaga gcacaatccc tcagagcccc tctcctgcac ctgatgaccc     2340

agaggagggc cggcagggtc aaactgagaa attccagttt gaactaactt tagaggaaga     2400

tggtgagtca gacacggaaa aggacagtgg cagtcaagtg gaagaagaca ctagctgcag     2460

tgactccaag actctttgta ctcaagactc agagtctact gaaattcccc ttgatgaaca     2520

ggttgaagag gaggcagtag gggaagaaga ggaaagccag cctgaagcct gtgtcataga     2580

tgatcgttct cctgacacgt aacagtgcaa aaactttcat gccttttttt tttttaagta     2640

gaaaaattgt ttccaaagtg catgtcacat gccacaacca cggtcacacc tcactgtcat     2700

ctgccaggac gtttgttgaa caaaactgac cttgactact cagtccagcg ctcaggaata     2760

tcgtaaccag ttttttcacc tccatgtcat ccgagcaagg tggacatctt cacgaacagc     2820

gtttttaaca agatttcagc ttggtagagc tgacaaagca gataaaatct actccaaatt     2880

attttcaaga gagtgtgact catcaggcag cccaaaagtt tattggactt ggggtttcta     2940

ttccttttta tttgtttgca atattttcag aagaaaggca ttgcacagag tgaacttaat     3000

ggacgaagca acaaatatgt caagaacagg acatagcacg aatctgttac cagtaggagg     3060

aggatgagcc acagaaattg cataattttc taatttcaag tcttcctgat acatgactga     3120

atagtgtggt tcagtgagct gcactgacct ctacattttg tatgatatgt aaaacagatt     3180

ttttgtagag cttactttta ttattaaatg tattgaggta ttatatttaa aaaaaactat     3240

gttcagaact tcatctgcca ctggttattt ttttctaagg agtaacttgc aagttttcag     3300

tacaaatctg tgctacactg gataaaaatc taatttatga attttacttg caccttatag     3360

ttcatagcaa ttaactgatt tgtagtgatt cattgtttgt tttatatacc aatgacttcc     3420

atattttaaa agagaaaaac aactttatgt tgcaggaaac cctttttgta agtctttatt     3480

atttactttg cattttgttt cactctttcc agataagcag agttgctctt caccagtgtt     3540

tttcttcatg tgcaaagtga ctatttgttc tataatactt ttatgtgtgt tatatcaaat     3600

gtgtcttaag cttcatgcaa actcagtcat cagttcgtgt tgtctgaagc aagtgggaga     3660

tatataaata cccagtagct aaaatggtca gtctttttta gatgttttcc tacttagtat     3720

ctcctaataa cgttttgctg tgtcactaga tgttcatttc acaagtgcat gtctttctaa     3780

taatccacac atttcatgct ctaataatcc acacatttca tgctcatttt tattgttttt     3840

acagccagtt atagtaagaa aaaggttttt ccccttgtgc tgctttataa tttagcgtgt     3900

gtctgaacct tatccatgtt tgctagatga ggtcttgtca aatatatcac taccattgtc     3960

accggtgaaa agaaacaggt agttaagtta gggttaacat tcatttcaac cacgaggttg     4020

tatatcatga ctagctttta ctcttggttt acagagaaaa gttaaacagc caactaggca     4080

gtttttaaga atattaacaa tatattaaca aacaccaata caactaatcc tatttggttt     4140

taatgatttc accatgggat taagaactat atcaggaaca tccctgagaa acggttttaa     4200

gtgtagcaac tactcttcct taatggacag ccacataacg tgtaggaagt cctttatcac     4260

ttatcctcga tccataagca tatcttgcag aggggaacta cttctttaaa cacatggagg     4320

gaaagaagat gatgccactg gcaccagagg gttagtactg tgatgcatcc taaaatattt     4380

attatattgg taaaaattct ggttaaataa aaaattagag atcactcttg gctgatttca     4440

gcaccaggaa ctgtattaca gttttagaga ttaattccta gtgtttacct gattatagca     4500

gttggcatca tggggcattt aattctgact ttatccccac gtcagcctta ataaagtctt     4560

ctttaccttc tctatgaaga ctttaaagcc caaataatca tttttcacat tgatattcaa     4620

gaattgagat agatagaagc caaagtgggt atctgacaag tggaaaatca aacgtttaag     4680

aagaattaca actctgaaaa gcatttatat gtggaacttc tcaaggagcc tcctggggac     4740

tggaaagtaa gtcatcagcc aggcaaatga ctcatgctga agagagtccc catttcagtc     4800

ccctgagatc tagctgatgc ttagatcctt tgaaataaaa attatgtctt tataactctg     4860

atcttttaca taaagcagaa gaggaatcaa ctagttaatt gcaaggtttc tactctgttt     4920

cctctgtaaa gatcagatgg taatctttca aataagaaaa aaataaagac gtatgtttga     4980

ccaagtagtt tcacaagaat atttgggaac ttgtttcttt taattttatt tgtccctgag     5040

tgaagtctag aaagaaaggt aaagagtcta gagtttattc ctctttccaa aacattctca     5100

ttcctctcct ccctacactt agtatttccc ccacagagtg cctagaatct taataatgaa     5160

taaaataaaa agcagcaata tgtcattaac aaatccagac ctgaaagggt aaagggttta     5220

taactgcact aataaagaga ggctcttttt ttttcttcca gtttgttggt ttttaatggt     5280

accgtgttgt aaagataccc actaatggac aatcaaattg cagaaaaggc tcaatatcca     5340

agagacaggg actaatgcac tgtacaatct gcttatcctt gcccttctct cttgccaaag     5400

tgtgcttcag aaatatatac tgctttaaaa aagaataaaa gaatatcctt ttacaagtgg     5460

ctttacattt cctaaaatgc cataagaaaa tgcaatatct gggtactgta tggggaaaaa     5520

aatgtccaag tttgtgtaaa accagtgcat ttcagcttgc aagttactga acacaataat     5580

gctgttttaa ttttgtttta tatcagttaa aattcacaat aatgtagata gaacaaatta     5640

cagacaagga aagaaaaaac ttgaatgaaa tggattttac agaaagcttt atgataattt     5700

ttgaatgcat tatttatttt ttgtgccatg catttttttt ctcaccaaat gaccttacct     5760

gtaatacagt cttgtttgtc tgtttacaac catgtattta ttgcaatgta catactgtaa     5820

tgttaattgt aaattatctg ttcttattaa aacatcatcc catgatggga tggtgttgat     5880

atatttggaa actcttggtg agagaatgaa tggtgtgtat acatactctg tacatttttc     5940

ttttctcctg taatatagtc ttgtcacctt agagcttgtt tatggaagat tcaagaaaac     6000

tataaaatac ttaaagatat ataaatttaa aaaaacatag ctgcaggtct ttggtcccag     6060

ggctgtgcct taactttaac caatattttc ttctgttttg ctgcatttga aaggtaacag     6120

tggagctagg gctgggcatt ttacatccag gcttttaatt gattagaatt ctgccaatag     6180

gtggatttta caaaaccaca gacaacctct gaaagattct gagacccttt tgagacagaa     6240

gctcttaagt acttcttgcc agggagcagc actgcatgtg tgatggttgt ttgccatctg     6300

ttgatcagga actacttcag ctacttgcat ttgattattt cctttttttt tttttttaac     6360

tcggaaacac aactggggaa atatattctt tcccagtgat tataaacaat ctttttcttt     6420

tttttaagtc cttttggctt ctagagctca taggaaaatg gacttgattt gaaattggag     6480

ccagagttta ctcgtgttgg ttatctattc atcagcttcc tgacatgtta agagaataca     6540

ttaaagagaa aatactgttt tttaatccta aaatttttct tccactaaga taaaccaaat     6600

gtccttacat atatgtaaac ccatctattt aaacgcaaag gtgggttgat gtcagtttac     6660

atagcagaaa gcattcacta tcctctaaga tttgtttctg caaaactttc attgctttag     6720

aattttaaaa tttcaccttg tacaatggcc agcccctaaa gcaggaaaca tttataatgg     6780

attatatgga aacatcctcc cagtacttgc ccagcccttg aatcatgtgg cttttcagtg     6840

aaaggaaaga ttctttttct aggaaaaatg agcctatttt attttatttt attttatttt     6900

ttgacacaaa ctgtagattt tagcagccct ggcccaaagg aatttgatta cttttgtttt     6960

aaacagtaca aaggggacac tataattaca aaaacatcct taactgattt gagttgtttt     7020

tatttctttg gatatatttt cagagtggta aattgtgtgt gagaattaca aatgattatt     7080

cttttagtgg tttcttagcc tctcttacag cccacgggga tagtactgta catcaatacc     7140

ttcatatgaa atttttatat gcaatgaaaa taaaagcatg ggttgattct gcctatttat     7200

gactcaatct tttacaaata aaagattatt cattttaaat tatagttcaa tcagcatgtc     7260

tcttaggata ctgaacgtgg ttgaaatgaa aggatagtga catcataagt tagtactgat     7320

attcataacc aaataaagcc aacttgagta attttgctac attaaaaatt accaaaatta     7380

cttagatggc ctataagatt aagcatggtg ttttctaagc aagctttgaa aggggccttc     7440

catacttact taattgaata ttctgggata ttgaaaatta ttcagatact tgacaattat     7500

ttttggttac ctactccgca aactacaaag ttttaaggac tcaacaataa gttaatgaga     7560

cacagtgttt gctttcatgg agcttacagt ctggagggga caaaggctta aacaatactc     7620

atataattat atatgtgatc agtacaatga aggagctcag tggggtaaat aagcaggaac     7680

ctgaacttga tctgttccgg agggccacag aaggcttcct tgaggccttg agaaagtgat     7740

ttgcatctga gttctgaagg attgtaagag gtaactaggg aaaaagttga caggaagagg     7800

aaggggatcc agacaagaaa catttgcaaa gatcttgagg cataaatgag cttgagacat     7860

ctggagaaac tgaggaaaag tgagagagta ggcagggcct ggagccgcag agccattgct     7920

aaccatcctg tgtgagatat cccccattct gtagctttat tctcataacc ctgctcaatt     7980

ttctttataa cacttctcac agatttatat acgtgtttgt ttttgttatc tgtctctccc     8040

accagaccac agctccatga gagcaaggtc tttgcttacc aatatatcac tagcacttaa     8100

aactatgcct ggtacacagt aggttcttaa tatgtgttga atatagccat caaattgata     8160

ttggatataa ttcaatctga taagatattt tgagatatta aagagttttt aacttgatac     8220

cataaaaaaa aaaaaaaaaa                                                 8240


<210>  260
<211>  809
<212>  PRT
<213>  Homo Sapiens

<400>  260

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  261
<211>  2521
<212>  DNA
<213>  Homo Sapiens

<400>  261
aggagcttag agtggagttt acaggaatga atcactgatt agcggcaggc ctaagtgtgg       60

gcactgtcgc accacacacc cagatactac tccaggcacg ggcattaggg gctcccacag      120

gctggacagg ccttggactt tcctggttga accgtgaggc cgcggtgtca gtccacactc      180

cactgtgggt ggcgggttcg gccccgcgag gaggcgccgc tctcaaaccc cacggtcccg      240

cgcagcgaag aggcgaggcg gccgcggaag gcaggcgcag cccactcttc ccgagaggcc      300

ccgacatctc ccggataatc tggagctttc aaaatgtttg ccaaagcaac caggaatttt      360

cttagagaag ttgatgctga tggtgacctg attgcagtat caaatctgaa tgactctgat      420

aagttacagc ttctaagtct ggtgacaaaa aagaagagat tctggtgctg gcagagaccc      480

aagtaccagt ttttatccct cacccttggc gatgtactca tagaagacca atttccgagt      540

ccagtggtcg tggagtcgga ctttgtgaaa tacgagggca agtttgcaaa ccacgtgagt      600

ggaaccctgg agactgcact ggggaaggtc aagctgaacc tggggggcag cagccgcgta      660

gagagccagt cttcatttgg aaccctgagg aagcaggagg tggatttgca gcagctcatc      720

agagactctg ccgagagaac aataaatctg agaaaccctg tgctccagca ggtgctggaa      780

ggaaggaatg aggtcctgtg cgttttgaca cagaagatca cgacgatgca gaagtgtgtg      840

atctctgagc acatgcaggt cgaggagaag tgtggtggca tcgtgggcat ccagaccaag      900

acggtgcagg tgtcagcgac ggaggatggg aatgtcacca aggactccaa cgtggtgctg      960

gagatcccag ctgccaccac cattgcctac ggtgtcattg agttatacgt gaaactggac     1020

ggccagttcg agttctgcct tctccgaggg aagcaaggtg gcttcgagaa caagaagaga     1080

attgactctg tctacctgga ccccctggtc tttcgagagt ttgcattcat agacatgcca     1140

gatgctgcgc atgggatatc ttcccaggat ggaccattaa gtgttttaaa gcaagcgacc     1200

ctgctcctgg agaggaattt ccatccattt gcggagctgc ctgagccaca acagacagct     1260

ttgagtgaca tcttccaggc ggtcctattt gatgatgaac tactcatggt cctggaacca     1320

gtgtgcgatg acctggtcag cggcctctcg cccacagtgg cggtgctggg ggagctgaag     1380

ccccggcagc agcaggacct tgtggccttc ctgcagctgg tggggtgcag cttacagggt     1440

gggtgtccgg gccccgagga tgcaggcagc aagcagctgt ttatgacagc ctacttcttg     1500

gtcagtgccc tcgcagaaat gccagatagc gcagcagctc tgctgggcac ttgctgcaaa     1560

ctccagatca ttcccacact gtgccacttg cttcgtgctc tgtctgatga tggagtatct     1620

gatcttgaag acccaacctt gactcccctg aaagatacag aaaggtttgg gattgtgcag     1680

cgcttgtttg cctcagctga cattagtctg gagagactga agtcatctgt gaaagctgtc     1740

attctgaagg actctaaagt cttcccactg cttctttgta taaccctgaa tggactctgt     1800

gctttaggca gagaacattc atgatgtcat atgtgaacta gaagtacgtg ttactggcca     1860

aggctatttt tcagaactgt taaaggtcat atgcacgtta aaagttgacc aatgaaatga     1920

atttacagaa cagtttaaga agtggtgaca ttttgcatga tgaatgacct gacttttagc     1980

caccaggtac tctttaaaca gttttcctta tcagaggccc tcctgtgctg gtgacccagc     2040

atctgagtta ggttccagca tgtaaagagc tgggagggcg gagaattctt agcatacatt     2100

cagacgtttt ttctgcacaa taataagtcc atctgtcact tgcattccac tttttgttac     2160

atagaaagag tctgaccctt taatccaaaa ggtcttttta cattgtgaat gctgtgggaa     2220

ggcaatttct ctgcacacaa gaggctacgt tttggaagtg atgtatgtta tttgatgact     2280

gaaaatgaac tgtaaatgct cctagagtat attcctctgc tgaacaaaat taaacttcaa     2340

aaaaatctaa cagtaacaca cccctgcttg ggaccctagc tatatgcatt ttatgtgacc     2400

ttgccatgct tcagtgaaca tactaattct atgtctagca catgttgatt tcctatgtat     2460

tctgggtatt ctattaaagg aaactttgaa ctatgaaaaa aaaaaaaaaa aaaaaaaaaa     2520

a                                                                     2521


<210>  262
<211>  496
<212>  PRT
<213>  Homo Sapiens

<400>  262

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  263
<211>  3549
<212>  DNA
<213>  Homo Sapiens

<400>  263
acatctggcg gctgccctcc cttgtttccg ctgcatccag acttcctcag gcggtggctg       60

gaggctgcgc atctggggct ttaaacatac aaagggattg ccaggacctg cggcggcggc      120

ggcggcggcg ggggctgggg cgcgggggcc ggaccatgag ccgctgagcc gggcaaaccc      180

caggccaccg agccagcgga ccctcggagc gcagccctgc gccgcggagc aggctccaac      240

caggcggcga ggcggccaca cgcaccgagc cagcgacccc cgggcgacgc gcggggccag      300

ggagcgctac gatggaggcg ctaatggccc ggggcgcgct cacgggtccc ctgagggcgc      360

tctgtctcct gggctgcctg ctgagccacg ccgccgccgc gccgtcgccc atcatcaagt      420

tccccggcga tgtcgccccc aaaacggaca aagagttggc agtgcaatac ctgaacacct      480

tctatggctg ccccaaggag agctgcaacc tgtttgtgct gaaggacaca ctaaagaaga      540

tgcagaagtt ctttggactg ccccagacag gtgatcttga ccagaatacc atcgagacca      600

tgcggaagcc acgctgcggc aacccagatg tggccaacta caacttcttc cctcgcaagc      660

ccaagtggga caagaaccag atcacataca ggatcattgg ctacacacct gatctggacc      720

cagagacagt ggatgatgcc tttgctcgtg ccttccaagt ctggagcgat gtgaccccac      780

tgcggttttc tcgaatccat gatggagagg cagacatcat gatcaacttt ggccgctggg      840

agcatggcga tggatacccc tttgacggta aggacggact cctggctcat gccttcgccc      900

caggcactgg tgttggggga gactcccatt ttgatgacga tgagctatgg accttgggag      960

aaggccaagt ggtccgtgtg aagtatggga acgccgatgg ggagtactgc aagttcccct     1020

tcttgttcaa tggcaaggag tacaacagct gcactgatac cggccgcagc gatggcttcc     1080

tctggtgctc caccacctac aactttgaga aggatggcaa gtacggcttc tgtccccatg     1140

aagccctgtt caccatgggc ggcaacgctg aaggacagcc ctgcaagttt ccattccgct     1200

tccagggcac atcctatgac agctgcacca ctgagggccg cacggatggc taccgctggt     1260

gcggcaccac tgaggactac gaccgcgaca agaagtatgg cttctgccct gagaccgcca     1320

tgtccactgt tggtgggaac tcagaaggtg ccccctgtgt cttccccttc actttcctgg     1380

gcaacaaata tgagagctgc accagcgccg gccgcagtga cggaaagatg tggtgtgcga     1440

ccacagccaa ctacgatgat gaccgcaagt ggggcttctg ccctgaccaa gggtacagcc     1500

tgttcctcgt ggcagcccac gagtttggcc acgccatggg gctggagcac tcccaagacc     1560

ctggggccct gatggcaccc atttacacct acaccaagaa cttccgtctg tcccaggatg     1620

acatcaaggg cattcaggag ctctatgggg cctctcctga cattgacctt ggcaccggcc     1680

ccacccccac gctgggccct gtcactcctg agatctgcaa acaggacatt gtatttgatg     1740

gcatcgctca gatccgtggt gagatcttct tcttcaagga ccggttcatt tggcggactg     1800

tgacgccacg tgacaagccc atggggcccc tgctggtggc cacattctgg cctgagctcc     1860

cggaaaagat tgatgcggta tacgaggccc cacaggagga gaaggctgtg ttctttgcag     1920

ggaatgaata ctggatctac tcagccagca ccctggagcg agggtacccc aagccactga     1980

ccagcctggg actgccccct gatgtccagc gagtggatgc cgcctttaac tggagcaaaa     2040

acaagaagac atacatcttt gctggagaca aattctggag atacaatgag gtgaagaaga     2100

aaatggatcc tggcttcccc aagctcatcg cagatgcctg gaatgccatc cccgataacc     2160

tggatgccgt cgtggacctg cagggcggcg gtcacagcta cttcttcaag ggtgcctatt     2220

acctgaagct ggagaaccaa agtctgaaga gcgtgaagtt tggaagcatc aaatccgact     2280

ggctaggctg ctgagctggc cctggctccc acaggccctt cctctccact gccttcgata     2340

caccgggcct ggagaactag agaaggaccc ggaggggcct ggcagccgtg ccttcagctc     2400

tacagctaat cagcattctc actcctacct ggtaatttaa gattccagag agtggctcct     2460

cccggtgccc aagaatagat gctgactgta ctcctcccag gcgccccttc cccctccaat     2520

cccaccaacc ctcagagcca cccctaaaga gatactttga tattttcaac gcagccctgc     2580

tttgggctgc cctggtgctg ccacacttca ggctcttctc ctttcacaac cttctgtggc     2640

tcacagaacc cttggagcca atggagactg tctcaagagg gcactggtgg cccgacagcc     2700

tggcacaggg cagtgggaca gggcatggcc aggtggccac tccagacccc tggcttttca     2760

ctgctggctg ccttagaacc tttcttacat tagcagtttg ctttgtatgc actttgtttt     2820

tttctttggg tcttgttttt tttttccact tagaaattgc atttcctgac agaaggactc     2880

aggttgtctg aagtcactgc acagtgcatc tcagcccaca tagtgatggt tcccctgttc     2940

actctactta gcatgtccct accgagtctc ttctccactg gatggaggaa aaccaagccg     3000

tggcttcccg ctcagccctc cctgcccctc ccttcaacca ttccccatgg gaaatgtcaa     3060

caagtatgaa taaagacacc tactgagtgg ccgtgtttgc catctgtttt agcagagcct     3120

agacaagggc cacagaccca gccagaagcg gaaacttaaa aagtccgaat ctctgctccc     3180

tgcagggcac aggtgatggt gtctgctgga aaggtcagag cttccaaagt aaacagcaag     3240

agaacctcag ggagagtaag ctctagtccc tctgtcctgt agaaagagcc ctgaagaatc     3300

agcaattttg ttgctttatt gtggcatctg ttcgaggttt gcttcctctt taagtctgtt     3360

tcttcattag caatcatatc agttttaatg ctactactaa caatgaacag taacaataat     3420

atccccctca attaatagag tgctttctat gtgcaaggca cttttcacgt gtcacctatt     3480

ttaacctttc caaccacata aataaaaaag gccattatta gttgaaaaaa aaaaaaaaaa     3540

aaaaaaaaa                                                             3549


<210>  264
<211>  660
<212>  PRT
<213>  Homo Sapiens

<400>  264

Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala 
1               5                   10                  15      


Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
            20                  25                  30          


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
        35                  40                  45              


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
    50                  55                  60                  


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
65                  70                  75                  80  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
                85                  90                  95      


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
            100                 105                 110         


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
        115                 120                 125             


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
    130                 135                 140                 


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
145                 150                 155                 160 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
                165                 170                 175     


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
            180                 185                 190         


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
        195                 200                 205             


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
    210                 215                 220                 


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
                245                 250                 255     


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
            260                 265                 270         


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
        275                 280                 285             


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
305                 310                 315                 320 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
                325                 330                 335     


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
            340                 345                 350         


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
        355                 360                 365             


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
    370                 375                 380                 


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
385                 390                 395                 400 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
                405                 410                 415     


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
            420                 425                 430         


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
        435                 440                 445             


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
    450                 455                 460                 


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
465                 470                 475                 480 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
                485                 490                 495     


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
            500                 505                 510         


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
        515                 520                 525             


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
    530                 535                 540                 


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
545                 550                 555                 560 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
                565                 570                 575     


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
            580                 585                 590         


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
        595                 600                 605             


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
    610                 615                 620                 


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
625                 630                 635                 640 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
                645                 650                 655     


Trp Leu Gly Cys 
            660 


<210>  265
<211>  3903
<212>  DNA
<213>  Homo Sapiens

<400>  265
agtgtgccag gaagggggcc gactgagcag tgtgtggaag ctgtcgtgga ggtgaccgtg       60

gggggatgag aaaaggggaa ggaaggaaca gacagcacca gagggacttg aacaaaggga      120

gaagggggat taaagtcaaa tcactgtcag cagcccagga gcagacaaaa ccaccagagt      180

aagccctgaa atggaaatga gagggaaaag aagcaagccg ctaacagcta ccaagaagag      240

gaggaagtgg gagatgcgct gcttcctgta gaaagaacgt tgattgaaga caaagctggg      300

tggggactag tccctgggct gcagccgctg ctacacatac tcacaacgct gccgccgcgc      360

tccgtgggca actcctacta ctgctgggct gggctgggct gggctgggct gcgccggagc      420

tcgcctgcac agatcagctc cggagagggg aaaaccacgc tcctcggacc aagcctcggg      480

agctaagcca gatctgccag tgagcctcag gctttaggaa ctgaagagtg tttctgaaag      540

atctatccag cactccgatg gccagcaaca acaccgccag catagcacaa gccaggaagc      600

tggtagagca gcttaagatg gaagccaata tcgacaggat aaaggtgtcc aaggcagctg      660

cagatttgat ggcctactgt gaagcacatg ccaaggaaga ccccctcctg acccctgttc      720

cggcttcaga aaacccgttt agggagaaga agtttttctg tgccatcctt taagtctttg      780

agaggggcct gaagagcctc cgggctcctg ggacattgat gtagagtttt tagtgaagtg      840

ggcacctttc tagtccacgg catttgaaga gagcgaggag aaccattctg gaaactctag      900

gctatgcatg tttaaagatc tggtcccctt tatgagaatg caagccgatc cacatcctga      960

cttaagagat ctgattctga cgaactgcct ggaggagggg aatatataaa aataaaattg     1020

gtgtcacttc ttttctgcta tcccccagcc ccccccccaa aatcctcatg tttctgcttc     1080

atattttgaa aaataacaat taaaacagac agctgtactg aggtaagata tgtgtgacct     1140

tcttggaatg aatattgtct ttagaatacc ctttgataag ctgagctgtc ccgtgtagat     1200

gcaattcggt ttaatggcat tgatgtatag tcactgtgcc tttctttttc tttcttcctt     1260

ctcctctacc cctccttcca cccctcccca ttagagtagt gtggagataa ggctggactg     1320

gtctatcaga ttgaactcca agaatgatca cacaaaatgt ttagggagat gttccccgtg     1380

gtgtatcctc atggtaacaa cgacaaaaaa tgccggttgt ctgtgttctc ttttcactat     1440

tcctaacatg tgtacatgat agctttgatt ctgcaagtaa aagtaaatcc tgtgttgtga     1500

ctggtgcttt catatatttg tgacaatttt tgagtaatat tgcatgaaaa tgtccctatg     1560

ttacatccat tcagaagttt tgttgtttta ctctaaagct gggaaaggaa atgagaggga     1620

aaagaccccg gagagggaag aaaatctcag tattttgaaa attgagatta cttcagagcc     1680

ttagccacac ctaaaatacc tcctagttaa tagtggtata aatgcctctt caatacgttt     1740

tccagaatcc aaagcatttt ggtttatcca ggacccaggg cagcacagct gtcaccaagc     1800

aggagagtta aggattcacc atgagctggg aaatgctttt gccatgagta tgagcaaatt     1860

ccctctttcc ctgaatcatg gacattctag attaaaagaa catttttttg tgctcttaac     1920

aagaaaacca tggccctcct ttgttcaagt atcagaagaa ataaacccac agctccagag     1980

aaggtgacca ttctcagaac tccagctatt cactctccag ggagaaggac ctcaaatcgc     2040

cactctttgg gcggcaggtg cggtccccac ggccggctct acgaggaaga gttctggctc     2100

ttttgtccac tgagatggtc ttggtttttc acttaacaaa ttttttaatg gaatctttgt     2160

ttttgttctc catcttgttt gttagagtct ctcggccttt atttacaaat tccttgcaac     2220

tagagcgctc cttccccaag atatggtagt gagagtaatt tttcattgta gctgtagtct     2280

ccatcagtaa cagcaggccc tggaagactt gatcaccttt ttctgtgtca ttttcagtca     2340

aagagggcct ctcttacatc ttgtttgctt tcaaatcccc aaatatcatc tccatctccc     2400

aattaatttt attgtctctt tcctctctat tcgctttctc ctgttttttt tttaaaaaaa     2460

aagcatgaaa aaggaagaga aaaagtttga tatgccaagg acagattttg aaacagactt     2520

ggtaaatgtt ttccttagct ccttcatggg catgctggtg aaagaataaa tacatccaat     2580

taaagctcat gctggggtcg gggagaagag gatactgaaa catttgtgaa atgtatgaat     2640

gcacttctgt aaccagatac ttctgttctt ctgttcaaat tgtggggttt ttgttacagt     2700

taggacgccc atgaagattt aggggtgaaa aaaacagcag agtatttatt aaactacagc     2760

attgtacaat tagcttagta acactatgga ataagctaaa acatatcaca gtttttacat     2820

gggccaaaac atgaattgag tatgtggtca catgaaaaca cggatgaatg aataaaacac     2880

tctttggtgg tgactgaggc atcattagaa ggcccagacg atttccacta ttcacagcat     2940

ttccttttct cagaaggact ctttatattt ccatgtaaat ctagatcttt ggagcaatta     3000

agatggaatt acaatttcta gggagcattt taaggaaaat gttttggctt tttcataatt     3060

ttatgtctta cagtatggaa ttataatacg aaaatcttta tatgagtttt ggcttcttgg     3120

tatttgtact tattcagggg aaaaagtctt tcgattactt atgcctctat agagcttaat     3180

ttcttgagaa attcaacagt cattttcacc agcataattt tatcttaagg aataactaat     3240

aggaaaagtc agcttaatta tttaaggccc tagtttctac atataatata ttcgatagaa     3300

atgaaaatct gccgtggaat taactaataa gtagtaacaa taaacttcat atttagaatg     3360

caaagtctat aaagaataat tttacatgat cctcaatatc aactccagtt taaaaagtgt     3420

tatttttaaa acatttgaaa ccaagtactg tttaatttca atcagaagat gcaaatacat     3480

actttgatct atgtttgatt ttgctaataa tatttgaagg agattgccta ccaaggacaa     3540

aacaataaat ttaaaaatca aacgatttct ccatacgctc atagtcacat atggaatttt     3600

gagaaaataa agcatgctgt ctttaggaat ttttatactt ctttgtcttt cttccttaat     3660

atttgcttct agctgctctt ggcaatgatg aattgttatg tatgcattaa tgttttgcag     3720

cccaaaagtt gttcacattt ttcctatata agatctgtgg agtgtgtgtt tcaaagagag     3780

aactacagaa atgttaaagc aggaaaacct gaatgtgatg tgcacatttt catcccacat     3840

ggacaatgta tgtgttttaa taaatggaat tttcagattc atttcaaaaa aaaaaaaaaa     3900

aaa                                                                   3903


<210>  266
<211>  71
<212>  PRT
<213>  Homo Sapiens

<400>  266

Met Ala Ser Asn Asn Thr Ala Ser Ile Ala Gln Ala Arg Lys Leu Val 
1               5                   10                  15      


Glu Gln Leu Lys Met Glu Ala Asn Ile Asp Arg Ile Lys Val Ser Lys 
            20                  25                  30          


Ala Ala Ala Asp Leu Met Ala Tyr Cys Glu Ala His Ala Lys Glu Asp 
        35                  40                  45              


Pro Leu Leu Thr Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys 
    50                  55                  60                  


Lys Phe Phe Cys Ala Ile Leu 
65                  70      


<210>  267
<211>  5143
<212>  DNA
<213>  Homo Sapiens

<400>  267
agttggaaag agaccacaga ctttgaggga agctcactca ggatctgctc tccggcaaag       60

tagtaagtga ggtgctgaga gcagaatgag ctactttgtg gattctgctg ggagcagccc      120

cgtcccttac tcagcgcctc gtcctgcagt ggtgaggcaa ggacctagca acacttatga      180

agatcctcga atgaactgtg gtttccagtc caattatcac cagcaaagac cttgctaccc      240

cttttgggat gagatggcaa ctcaggaagt tcctactggt cttgaacact gtgtctcaga      300

tatggaatgt gcagatgtcc cactattaac tccaagcagc aaagaaatga tgtctcaagc      360

attaaaagct actttcagtg gtttcactaa agaacagcaa cgactgggga tcccaaaaga      420

cccccggcag tggacagaaa cccatgttcg ggactgggtg atgtgggctg tgaatgaatt      480

cagcctgaaa ggtgtagact tccagaagtt ctgtatgaat ggagcagccc tctgcgccct      540

gggtaaagac tgctttctcg agctggcccc agactttgtt ggggacatct tatgggaaca      600

tctagagatc ctgcagaaag aggatgtgaa accatatcaa gttaatggag tcaacccagc      660

ctatccagaa tcccgctata cctcggatta cttcattagc tatggtattg agcatgccca      720

gtgtgttcca ccatcggagt tctcagagcc cagcttcatc acagagtcct atcagacgct      780

ccatcccatc agctcggaag agctcctctc cctcaagtat gagaatgact acccctcggt      840

cattctccga gaccctctcc agacagacac cttgcagaat gactactttg ctatcaaaca      900

agaagtcgtc accccagaca acatgtgcat ggggaggacc agtcgtggta aactcggggg      960

ccaggactct tttgaaagca tagagagcta cgatagttgt gatcgcctca cccagtcctg     1020

gagcagccag tcatctttca acagcctgca gcgtgttccc tcctatgaca gcttcgactc     1080

agaggactat ccggctgccc tgcccaacca caagcccaag ggcaccttca aggactatgt     1140

gcgggaccgt gctgacctca ataaggacaa gcctgtcatt cctgctgctg ccctagctgg     1200

ctacacaggc agtggaccaa tccagctatg gcagtttctt ctggaattac tcactgataa     1260

atcctgtcag tcttttatca gctggacagg agatggctgg gaattcaaac tttctgaccc     1320

agatgaggtg gccaggagat ggggaaagag gaaaaacaaa cctaagatga attatgagaa     1380

actgagccgt ggcctacgct actattacga caaaaacatc atccacaaga cagcggggaa     1440

acgctacgtg taccgctttg tgtgtgacct gcagagcctg ctggggtaca cccctgagga     1500

gctgcacgcc atgctggacg tcaagccaga tgccgacgag tgatggcact gaaggggctg     1560

gggaaaccct gctgagacct tccaaggaca gccgtgttgg ttggactctg aattttgaat     1620

tgttattcta ttttttattt tccagaactc attttttacc ttcaggggtg ggagctaagt     1680

cagttgcagc tgtaatcaat tgtgcgcagt tgggaaagga aagccaggac ttgtggggtg     1740

ggtgggacca gaaattcttg agcaaatttt caggagaggg agaagggcct tctcagaagc     1800

ttgaaggctc tggcttaaca gagaaagaga ctaatgtgtc caatcatttt taaaaatcat     1860

ccatgaaaaa gtgtcttgag ttgtggaccc attagcaagt gacattgtca catcagaact     1920

catgaaactg atgtaaggca attaatttgc ttctgttttt aggtctggga gggcaaaaaa     1980

gaggtgggtg ggatgaaaca tgttttgggg ggggatgcac tgaaaatctg agaactattt     2040

acctatcact ctagttttga agcaaagatg gacttcagtg gggaggggcc aaaaccgttg     2100

ttgtgttaaa atttatttta ttaaattttg tgccagtatt ttttttctta aaaatcgtct     2160

taagctctaa ggtggtctca gtattgcaat atcatgtaag tttgttttta tttgccggct     2220

gaggattctg tcacaatgaa agaaaactgt ttatatagac cccattggaa aagcaaaacg     2280

ctctcactga gatcagggat cccaaattca tgggacttat ataagaagga caattaatgc     2340

tgatttgggt acaggggaat tatgtgtgtg aatgtcatct acaattaaaa aaaattagca     2400

catcccttta cttacttgtt atcagtggat tctcggggtt tggacttaat gttgagctaa     2460

gaagcattaa gtctttgaac tgaatgtatt ttgcatccct ggttttggac gacagtaaac     2520

gtaggagcac tgttgaagtc ctggaaggga gatcgaagga ggaagattga cttggttctt     2580

tcttagtcct atatctgtag catagatgac ttggaataaa agctgtatgc atgggcatta     2640

cccctcaggt cctaagaaat aagtcctgaa tgcatgtcgt tccaaactaa cactctgtaa     2700

tttttctttt atgtcttatt ttccaagagt cctccatttt ttgcaccccc tcaccgccaa     2760

ctctgttatt cagtagagag aagtgtacgg ctttctgatt ggtgagtgaa aaagtaactt     2820

gagacacgac ctaagttgaa gagtttagac ttgctgagtt ttagaagtga tggaaattaa     2880

gagagcattt caataaaatg tgacttggct gtctttggaa gagaagtgca aggctttcct     2940

ttgaagaatt taaattagtc cggtaggatg tcaggtgaga ctgtgtatgc aaaatgaatg     3000

gcacaggtga tgccagggcc tcttgcttgg gtctgatgtc ttggcacagg gtaagtgaag     3060

gttaattcca gaagagagga atgacttgaa ggcaaaggaa actaaggaag gaggttcagt     3120

gaggaaaata aggttgtcca tgagatttga atagattttt agttccccca aggtttaaat     3180

acaaacatag tcaagcaagg tagtcatctt tctgctggtt gtgaggggga atctgaaaat     3240

ggagttttag aggaaaagtc aacatctaac tagtgaggaa aagtgcctaa tacaattaga     3300

atctccctca ctctatagtt gcccagttga aaggataagg aggaggggtg gcttttatgg     3360

acttccatga gagaaggaaa gaaatatttc aggtaagctt ctcagggctg gccctttttg     3420

ggatttggat gagaaattgg aagtactaac tactttctag catatcttta agaaaattga     3480

ttgttattta ctcccagatc ctcttgcaga cccagaatta tcaggaacat agctctgtga     3540

ttcatgagtg tccccatact gatgaattgg agcatccata tggaaagcaa aggcagaatt     3600

atcccagctg tattattttg atcttttgga tgcaggtgcc ttaatgaagc tctcaaaata     3660

ttttaggagc tgctcaggga gtgttgggtg gaactgtttg gactacattg ttttctctta     3720

gattatgtga tttttgttgg gcactggcaa aaggtgtgtg tgtgaatgtg tgcatgtgtg     3780

tgaatgttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttgcagac     3840

atgcaaaact gcagctgaaa taatacctta gatttctagg taagtctttc cacatttcaa     3900

taatgggtaa gagtagaacc agggccgggt atcaattatt gcttgctgtt tgcaaccagg     3960

cataaaatca ctttctcaaa tcatccaccg ttcctattaa atttatgccg gaaactctcc     4020

ttctgtgagt ataactcctg cagttcctat agcagataag atataagaaa gtgcctccta     4080

gtgctcctcc gcccgcttgt ttgctaaaat tccctttctc tctaagtcca ccattttcaa     4140

gatttgtaga tagtgtatta gttaagacag ctttgtcgat ctggccagat gttttttctc     4200

ctttgtccaa aggccagaga ccatcccagg aagagtggtg ggtggtttat acactggaaa     4260

tgttgcgttt atgcttttta aaaacacacg ttaacttcag aggaaggatg ggcaaatctg     4320

gtctagctgg gtgaaaccct tattttccca gagatgcctt aacctttgtt ggttttggct     4380

ttagggttca gagtcacttt tgttcccttc tccattctgg agagggactt cccctacata     4440

gagccctgat ttttgtggct gtggggattg gaggtagcat tcaaagatca gatgtgcttt     4500

tcctcacttt ggagatgaac actctgggtt ttacagcatt aacctgccta accttcatgg     4560

tgagaaatac accatctctc ttctagtcat gctgtgcatg ccgcttactc tgttggggtc     4620

tatataaatt tgttgaactc ttacctacat tccaaagaag tttcaaggaa ccataaatat     4680

atgtatacat atacatatat aaaatatata tattaaaata aaattatcag gaatactgcc     4740

tcagttattg aacttttttt tttaagaata cttttttttt aagctgagaa gtatagggat     4800

gaaaaagatg ttatattgtg tttgactatt ttccaacttg tattttcata taatttatat     4860

tttttaaaag ctgaaaattt agaagcaaga tgaaaaaaag gaaaagcagg tgctttttaa     4920

aaatcagaac tgaggtagct tagagatgta gcgatgtaag tgtcgatgtt tttttaaaaa     4980

aaaatgcaaa aaaattctta tggcggagtt ttttgtttgt ttattttagt agctgatgct     5040

ggcacatcat tttgctggag agttttttat atactgtagc ctgatttcat attgtatttt     5100

aaactgtgtg aaattaaaaa caaagaattt cattcataat gct                       5143


<210>  268
<211>  485
<212>  PRT
<213>  Homo Sapiens

<400>  268

Met Ser Tyr Phe Val Asp Ser Ala Gly Ser Ser Pro Val Pro Tyr Ser 
1               5                   10                  15      


Ala Pro Arg Pro Ala Val Val Arg Gln Gly Pro Ser Asn Thr Tyr Glu 
            20                  25                  30          


Asp Pro Arg Met Asn Cys Gly Phe Gln Ser Asn Tyr His Gln Gln Arg 
        35                  40                  45              


Pro Cys Tyr Pro Phe Trp Asp Glu Met Ala Thr Gln Glu Val Pro Thr 
    50                  55                  60                  


Gly Leu Glu His Cys Val Ser Asp Met Glu Cys Ala Asp Val Pro Leu 
65                  70                  75                  80  


Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala Leu Lys Ala Thr 
                85                  90                  95      


Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly Ile Pro Lys Asp 
            100                 105                 110         


Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp Val Met Trp Ala 
        115                 120                 125             


Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln Lys Phe Cys Met 
    130                 135                 140                 


Asn Gly Ala Ala Leu Cys Ala Leu Gly Lys Asp Cys Phe Leu Glu Leu 
145                 150                 155                 160 


Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His Leu Glu Ile Leu 
                165                 170                 175     


Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly Val Asn Pro Ala 
            180                 185                 190         


Tyr Pro Glu Ser Arg Tyr Thr Ser Asp Tyr Phe Ile Ser Tyr Gly Ile 
        195                 200                 205             


Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser Glu Pro Ser Phe 
    210                 215                 220                 


Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser Ser Glu Glu Leu 
225                 230                 235                 240 


Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val Ile Leu Arg Asp 
                245                 250                 255     


Pro Leu Gln Thr Asp Thr Leu Gln Asn Asp Tyr Phe Ala Ile Lys Gln 
            260                 265                 270         


Glu Val Val Thr Pro Asp Asn Met Cys Met Gly Arg Thr Ser Arg Gly 
        275                 280                 285             


Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Ile Glu Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Ser Glu Asp Tyr Pro 
                325                 330                 335     


Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe Lys Asp Tyr Val 
            340                 345                 350         


Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val Ile Pro Ala Ala 
        355                 360                 365             


Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe 
    370                 375                 380                 


Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp 
385                 390                 395                 400 


Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro Asp Glu Val Ala 
                405                 410                 415     


Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys 
            420                 425                 430         


Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys 
        435                 440                 445             


Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Ser 
    450                 455                 460                 


Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met Leu Asp Val Lys 
465                 470                 475                 480 


Pro Asp Ala Asp Glu 
                485 


<210>  269
<211>  1502
<212>  DNA
<213>  Homo Sapiens

<400>  269
atcacaatca gaagacagga gctgcagaac agaacacttt ctcatgtcca gggtcagatt       60

acaagagcac tcaagacttt actgacgaaa actcaggaaa tcctctatca caaagaggtt      120

tggcaactaa actaagacat taaaaggaaa ataccagatg ccactctgca ggttgcaata      180

actactactt actggataca ttcaaaccct ccagaatcaa cagttatcag gtaaccaaca      240

agaaatgcaa gccgtcgaca acctcacctc tgcgcctggt aacaccagtc tgtgcaccag      300

agactacaaa atcacccagg tcctcttccc actgctctac actgtcctgt tttttgttgg      360

acttatcaca aatggcctgg cgatgaggat tttctttcaa atccggagta aatcaaactt      420

tattattttt cttaagaaca cagtcatttc tgatcttctc atgattctga cttttccatt      480

caaaattctt agtgatgcca aactgggaac aggaccactg agaacttttg tgtgtcaagt      540

tacctccgtc atattttatt tcacaatgta tatcagtatt tcattcctgg gactgataac      600

tatcgatcgc taccagaaga ccaccaggcc atttaaaaca tccaacccca aaaatctctt      660

gggggctaag attctctctg ttgtcatctg ggcattcatg ttcttactct ctttgcctaa      720

catgattctg accaacaggc agccgagaga caagaatgtg aagaaatgct ctttccttaa      780

atcagagttc ggtctagtct ggcatgaaat agtaaattac atctgtcaag tcattttctg      840

gattaatttc ttaattgtta ttgtatgtta tacactcatt acaaaagaac tgtaccggtc      900

atacgtaaga acgaggggtg taggtaaagt ccccaggaaa aaggtgaacg tcaaagtttt      960

cattatcatt gctgtattct ttatttgttt tgttcctttc cattttgccc gaattcctta     1020

caccctgagc caaacccggg atgtctttga ctgcactgct gaaaatactc tgttctatgt     1080

gaaagagagc actctgtggt taacttcctt aaatgcatgc ctggatccgt tcatctattt     1140

tttcctttgc aagtccttca gaaattcctt gataagtatg ctgaagtgcc ccaattctgc     1200

aacatctctg tcccaggaca ataggaaaaa agaacaggat ggtggtgacc caaatgaaga     1260

gactccaatg taaacaaatt aactaaggaa atatttcaat ctctttgtgt tcagaactcg     1320

ttaaagcaaa gcgctaagta aaaatattaa ctgacgaaga agcaactaag ttaataataa     1380

tgactctaaa gaaacagaag attacaaaag caattttcat ttacctttcc agtatgaaaa     1440

gctatcttaa aatatagaaa actaatctaa actgtagctg tattagcagc aaaacaaacg     1500

ac                                                                    1502


<210>  270
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  270

Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 
1               5                   10                  15      


Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 
            20                  25                  30          


Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 
        35                  40                  45              


Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys 
    50                  55                  60                  


Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys 
65                  70                  75                  80  


Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val 
                85                  90                  95      


Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile 
            100                 105                 110         


Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg 
        115                 120                 125             


Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 
    130                 135                 140                 


Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 
145                 150                 155                 160 


Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 
                165                 170                 175     


Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr 
            180                 185                 190         


Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys 
        195                 200                 205             


Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg 
    210                 215                 220                 


Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile 
225                 230                 235                 240 


Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg 
                245                 250                 255     


Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 
            260                 265                 270         


Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 
        275                 280                 285             


Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 
    290                 295                 300                 


Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr 
305                 310                 315                 320 


Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro 
                325                 330                 335     


Asn Glu Glu Thr Pro Met 
            340         


<210>  271
<211>  3647
<212>  DNA
<213>  Homo Sapiens

<400>  271
aaaagagaca gggctgcttt aagagagaaa caggaagttg taactagaag ccatctgaat       60

actaagccag ggcagaatgc ttgtgaagta gcaactaaag tggcagtgtt tcttctgaaa      120

ttctcaggca gtcagactgt cttaggcaaa tcttgataaa atagccttta tccaggtttt      180

tatctaagga atcccaagaa gactggggaa tggagagaca gtcaagggtt atgtcagaaa      240

aggatgagta tcagtttcaa catcagggag cggtggagct gcttgtcttc aattttttgc      300

tcatccttac cattttgaca atctggttat ttaaaaatca tcgattccgc ttcttgcatg      360

aaactggagg agcaatggtg tatggcctta taatgggact aattttacga tatgctacag      420

caccaactga tattgaaagt ggaactgtct atgactgtgt aaaactaact ttcagtccat      480

caactctgct ggttaatatc actgaccaag tttatgaata taaatacaaa agagaaataa      540

gtcagcacaa catcaatcct catcaaggaa atgctatact tgaaaagatg acatttgatc      600

cagaaatctt cttcaatgtt ttactgccac caattatatt tcatgcagga tatagtctaa      660

agaagagaca cttttttcaa aacttaggat ctattttaac gtatgccttc ttgggaactg      720

ccatctcctg catcgtcata gggttaatta tgtatggttt tgtgaaggct atgatacatg      780

ctggccagct gaaaaatgga gactttcatt tcactgactg tttatttttt ggttcactga      840

tgtctgctac agatccagtg acagtgctgg ccattttcca tgaactgcac gtcgaccctg      900

acctgtacac actcttgttt ggagagagtg tgttgaatga tgcagtggcc atagtcctta      960

catattctat atccatttac agtcccaagg agaatccaaa tgcatttgat gccgcagcat     1020

tcttccagtc tgtggggaat ttcctgggaa tcttcgctgg ctcatttgca atggggtctg     1080

cgtatgccat catcacagca ctgttgacca aatttaccaa gctgtgtgag ttcccgatgc     1140

tggaaaccgg cctgtttttc ctgctttctt ggagtgcctt cctgtctgcc gaggctgccg     1200

gcctaacagg gatagttgct gttctcttct gtggagtcac acaagcacat tatacctaca     1260

acaatctgtc ttcggattcc aaaataagaa ctaaacagtt gtttgaattt atgaactttt     1320

tggcggagaa cgtcatcttc tgttacatgg gcctggcact gttcacgttc cagaatcata     1380

tctttaatgc tctttttata cttggagcct ttctagcaat ttttgttgcc agagcctgca     1440

acatatatcc cctctccttc ctcctgaatc taggccgaaa acagaagatc ccctggaact     1500

ttcagcacat gatgatgttt tcaggtttgc gaggagcgat cgcatttgcc ttagctattc     1560

ggaacacaga atctcagccc aaacaaatga tgtttaccac tacgctgctc ctcgtgttct     1620

tcactgtctg ggtatttgga ggaggaacaa cccccatgtt gacttggctt cagatcagag     1680

ttggcgtgga cctggatgaa aatctgaagg aggacccctc ctcacaacac caggaagcaa     1740

ataacttgga taaaaacatg acgaaagcag agagtgctcg gctcttcaga atgtggtata     1800

gctttgacca caagtatctg aaaccaattt taacccactc tggtcctccg ctgactacaa     1860

cattacctga atggtgtggt ccgatttcca ggctgcttac cagtcctcaa gcctatgggg     1920

aacagctaaa agaggatgat gtggaatgca ttgtaaacca ggatgaacta gccataaatt     1980

accaggagca agcctcctca ccctgcagtc ctcctgcaag gctaggtctg gaccagaaag     2040

cttcacccca gacgccaggc aaggaaaaca tttatgaggg agacctcggc ctgggaggct     2100

atgaactcaa gcttgagcaa actttgggtc aatcccagtt gaattaattg gcatgaagag     2160

tacagatgta atcacaagta atgcaagact cactgaggaa tacaagccaa gctgatgagg     2220

cagtacaggg gagaggctgg aaaacatatt aagagcataa attggagaga atcaaagcct     2280

tgtcacatgg atcctctggt gcctgaagaa atgagatttt attatccctc tctattatgc     2340

aaatgaattt agttttttga cagcagccat tctgattact ggattggctg gggtggggat     2400

ggaggtatca ggagtctagc tgctggagga tgggacagct gtgctgggtc ttcagggcat     2460

ttctgctgcg aatgcggctc tccaggccct tcacttctat tctggatttt attccctcca     2520

ttaaggagag tttaaaaata aaagaaagct tctgagagta aacattttgc tcctaagctg     2580

aagggaatgc ccagctattt agtaagtgat aagtttctta ttttgaggac ttgactccca     2640

tttgctctca gtgaccccag ggcagagccc agagaagtgt tccgtaccca ctgctgatgg     2700

tttcccagag cccacactga gttgaagaac ctattgttct tcttggcatc cttcttatgc     2760

tacttctccc atcgctcaaa ggggttgcct atggctgggt gtgccctgcc ctaaatgcag     2820

caccactttc aagcttagta ggaccattcc aagaaaacca ggtttcttct ccccatacca     2880

cgttgtgcct gaagaacaag ccttcccgtc cttgcctgca tgtgagtcac ttcttggctg     2940

tgcagcaggt ccccccctcc ccgcgatatg ctggagggta ggattctgca gcctgtgttg     3000

ctctctacct ggcagcagac tgtgcaggag ccccaacctg tcctccaatt ccagcattca     3060

cagctgatga gcagtgcagg agcagggcga gaggaacaga gccaatgatg tgtgggttac     3120

actgaggagc caaggacagg gcctcaggtc tcccccttac aaggcgtggc tcatggcctg     3180

cattccagag accaacatga tagcttttaa ttcagctgca tgacctgtgc cttttaagcc     3240

ataaagatac ctcaagccta gcacctcttg aaatccagat gttcatatta gactcgaaaa     3300

aataggctcc aggcctaggt gcccaggcta tgatgagtct gcttttgaag gaggtaggga     3360

atgacatctt ccttggaccc aaagcttaaa agtaatgtat gctttgctga ccactgtttg     3420

ttaggcctta aacaacattc actgtggtgg tatcaggcac actgctatgt gcatcaatta     3480

tttttttgct ttccaaacag aatctctggg gcacaagttt tacactcaag ctaagtataa     3540

ctttgtcatt tcaggtaaat atgacaagtg gtggagcatg aagttttcta atttgactta     3600

atcctaataa atttttgtta caaagtaaaa aaaaaaaaaa aaaaaaa                   3647


<210>  272
<211>  645
<212>  PRT
<213>  Homo Sapiens

<400>  272

Met Glu Arg Gln Ser Arg Val Met Ser Glu Lys Asp Glu Tyr Gln Phe 
1               5                   10                  15      


Gln His Gln Gly Ala Val Glu Leu Leu Val Phe Asn Phe Leu Leu Ile 
            20                  25                  30          


Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys Asn His Arg Phe Arg Phe 
        35                  40                  45              


Leu His Glu Thr Gly Gly Ala Met Val Tyr Gly Leu Ile Met Gly Leu 
    50                  55                  60                  


Ile Leu Arg Tyr Ala Thr Ala Pro Thr Asp Ile Glu Ser Gly Thr Val 
65                  70                  75                  80  


Tyr Asp Cys Val Lys Leu Thr Phe Ser Pro Ser Thr Leu Leu Val Asn 
                85                  90                  95      


Ile Thr Asp Gln Val Tyr Glu Tyr Lys Tyr Lys Arg Glu Ile Ser Gln 
            100                 105                 110         


His Asn Ile Asn Pro His Gln Gly Asn Ala Ile Leu Glu Lys Met Thr 
        115                 120                 125             


Phe Asp Pro Glu Ile Phe Phe Asn Val Leu Leu Pro Pro Ile Ile Phe 
    130                 135                 140                 


His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Gln Asn Leu Gly 
145                 150                 155                 160 


Ser Ile Leu Thr Tyr Ala Phe Leu Gly Thr Ala Ile Ser Cys Ile Val 
                165                 170                 175     


Ile Gly Leu Ile Met Tyr Gly Phe Val Lys Ala Met Ile His Ala Gly 
            180                 185                 190         


Gln Leu Lys Asn Gly Asp Phe His Phe Thr Asp Cys Leu Phe Phe Gly 
        195                 200                 205             


Ser Leu Met Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe His 
    210                 215                 220                 


Glu Leu His Val Asp Pro Asp Leu Tyr Thr Leu Leu Phe Gly Glu Ser 
225                 230                 235                 240 


Val Leu Asn Asp Ala Val Ala Ile Val Leu Thr Tyr Ser Ile Ser Ile 
                245                 250                 255     


Tyr Ser Pro Lys Glu Asn Pro Asn Ala Phe Asp Ala Ala Ala Phe Phe 
            260                 265                 270         


Gln Ser Val Gly Asn Phe Leu Gly Ile Phe Ala Gly Ser Phe Ala Met 
        275                 280                 285             


Gly Ser Ala Tyr Ala Ile Ile Thr Ala Leu Leu Thr Lys Phe Thr Lys 
    290                 295                 300                 


Leu Cys Glu Phe Pro Met Leu Glu Thr Gly Leu Phe Phe Leu Leu Ser 
305                 310                 315                 320 


Trp Ser Ala Phe Leu Ser Ala Glu Ala Ala Gly Leu Thr Gly Ile Val 
                325                 330                 335     


Ala Val Leu Phe Cys Gly Val Thr Gln Ala His Tyr Thr Tyr Asn Asn 
            340                 345                 350         


Leu Ser Ser Asp Ser Lys Ile Arg Thr Lys Gln Leu Phe Glu Phe Met 
        355                 360                 365             


Asn Phe Leu Ala Glu Asn Val Ile Phe Cys Tyr Met Gly Leu Ala Leu 
    370                 375                 380                 


Phe Thr Phe Gln Asn His Ile Phe Asn Ala Leu Phe Ile Leu Gly Ala 
385                 390                 395                 400 


Phe Leu Ala Ile Phe Val Ala Arg Ala Cys Asn Ile Tyr Pro Leu Ser 
                405                 410                 415     


Phe Leu Leu Asn Leu Gly Arg Lys Gln Lys Ile Pro Trp Asn Phe Gln 
            420                 425                 430         


His Met Met Met Phe Ser Gly Leu Arg Gly Ala Ile Ala Phe Ala Leu 
        435                 440                 445             


Ala Ile Arg Asn Thr Glu Ser Gln Pro Lys Gln Met Met Phe Thr Thr 
    450                 455                 460                 


Thr Leu Leu Leu Val Phe Phe Thr Val Trp Val Phe Gly Gly Gly Thr 
465                 470                 475                 480 


Thr Pro Met Leu Thr Trp Leu Gln Ile Arg Val Gly Val Asp Leu Asp 
                485                 490                 495     


Glu Asn Leu Lys Glu Asp Pro Ser Ser Gln His Gln Glu Ala Asn Asn 
            500                 505                 510         


Leu Asp Lys Asn Met Thr Lys Ala Glu Ser Ala Arg Leu Phe Arg Met 
        515                 520                 525             


Trp Tyr Ser Phe Asp His Lys Tyr Leu Lys Pro Ile Leu Thr His Ser 
    530                 535                 540                 


Gly Pro Pro Leu Thr Thr Thr Leu Pro Glu Trp Cys Gly Pro Ile Ser 
545                 550                 555                 560 


Arg Leu Leu Thr Ser Pro Gln Ala Tyr Gly Glu Gln Leu Lys Glu Asp 
                565                 570                 575     


Asp Val Glu Cys Ile Val Asn Gln Asp Glu Leu Ala Ile Asn Tyr Gln 
            580                 585                 590         


Glu Gln Ala Ser Ser Pro Cys Ser Pro Pro Ala Arg Leu Gly Leu Asp 
        595                 600                 605             


Gln Lys Ala Ser Pro Gln Thr Pro Gly Lys Glu Asn Ile Tyr Glu Gly 
    610                 615                 620                 


Asp Leu Gly Leu Gly Gly Tyr Glu Leu Lys Leu Glu Gln Thr Leu Gly 
625                 630                 635                 640 


Gln Ser Gln Leu Asn 
                645 


<210>  273
<211>  2725
<212>  DNA
<213>  Homo Sapiens

<400>  273
agaatgctga gcagtcaaca gcatttcttg ttccaagatc acccttctga gtacctctct       60

ggctgccaaa ttgccagggc cttcacagtt tgattccatt tctcagctcc aagcattagg      120

taaacccacc aagcaatcct agcctgtgat ggcgtttgac gtcagctgct tcttttgggt      180

ggtgctgttt tctgccggct gtaaagtcat cacctcctgg gatcagatgt gcattgagaa      240

agaagccaac aaaacatata actgtgaaaa tttaggtctc agtgaaatcc ctgacactct      300

accaaacaca acagaatttt tggaattcag ctttaatttt ttgcctacaa ttcacaatag      360

aaccttcagc agactcatga atcttacctt tttggattta actaggtgcc agattaactg      420

gatacatgaa gacacttttc aaagccatca tcaattaagc acacttgtgt taactggaaa      480

tcccctgata ttcatggcag aaacatcgct taatgggccc aagtcactga agcatctttt      540

cttaatccaa acgggaatat ccaatctcga gtttattcca gtgcacaatc tggaaaactt      600

ggaaagcttg tatcttggaa gcaaccatat ttcctccatt aagttcccca aagacttccc      660

agcacggaat ctgaaagtac tggattttca gaataatgct atacactaca tctctagaga      720

agacatgagg tctctggagc aggccatcaa cctaagcctg aacttcaatg gcaataatgt      780

taaaggtatt gagcttgggg cttttgattc aacgatcttc caaagtttga actttggagg      840

aactccaaat ttgtctgtta tattcaatgg tctgcagaac tctactactc agtctctctg      900

gctgggaaca tttgaggaca ttgatgacga agatattagt tcagccatgc tcaagggact      960

ctgtgaaatg tctgttgaga gcctcaacct gcaggaacac cgcttctctg acatctcatc     1020

caccacattt cagtgcttca cccaactcca agaattggat ctgacagcaa ctcacttgaa     1080

agggttaccc tctgggatga agggtctgaa cttgctcaag aaattagttc tcagtgtaaa     1140

tcatttcgat caattgtgtc aaatcagtgc tgccaatttc ccctccctta cacacctcta     1200

catcagaggc aacgtgaaga aacttcacct tggtgttggc tgcttggaga aactaggaaa     1260

ccttcagaca cttgatttaa gccataatga catagaggct tctgactgct gcagtctgca     1320

actcaaaaac ctgtcccact tgcaaacctt aaacctgagc cacaatgagc ctcttggtct     1380

ccagagtcag gcattcaaag aatgtcctca gctagaactc ctcgatttgg catttacccg     1440

cttacacatt aatgctccac aaagtccctt ccaaaacctc catttccttc aggttctgaa     1500

tctcacttac tgcttccttg ataccagcaa tcagcatctt ctagcaggcc taccagttct     1560

ccggcatctc aacttaaaag ggaatcactt tcaagatggg actatcacga agaccaacct     1620

acttcagacc gtgggcagct tggaggttct gattttgtcc tcttgtggtc tcctctctat     1680

agaccagcaa gcattccaca gcttgggaaa aatgagccat gtagacttaa gccacaacag     1740

cctgacatgc gacagcattg attctcttag ccatcttaag ggaatctacc tcaatctggc     1800

tgccaacagc attaacatca tctcaccccg tctcctccct atcttgtccc agcagagcac     1860

cattaattta agtcataacc ccctggactg cacttgctcg aatattcatt tcttaacatg     1920

gtacaaagaa aacctgcaca aacttgaagg ctcggaggag accacgtgtg caaacccgcc     1980

atctctaagg ggagttaagc tatctgatgt caagctttcc tgtgggatta cagccatagg     2040

cattttcttt ctcatagtat ttctattatt gttggctatt ctgctatttt ttgcagttaa     2100

ataccttctc aggtggaaat accaacacat ttagtgctga aggtttccag agaaagcaaa     2160

taagtgtgct tagcaaaatt gctctaagtg aaagaactgt catctgctgg tgaccagacc     2220

agacttttca gattgcttcc tggaactggg cagggactca ctgtgctttt ctgagcttct     2280

tactcctgtg agtcccagag ctaaagaacc ttctaggcaa gtacaccgaa tgactcagtc     2340

cagagggtca gatgctgctg tgagaggcac agagcccttt ccgcatgtgg aagagtggga     2400

ggaagcagag ggagggactg ggcagggact gccggccccg gagtctccca cagggaggcc     2460

attccccttc tactcaccga catccctccc agcaccacac accccgcccc tgaaaggaga     2520

tcatcagccc ccacaatttg tcagagctga agccagccca ctacccaccc ccactacagc     2580

attgtgcttg ggtctgggtt ctcagtaatg tagccatttg agaaacttac ttggggacaa     2640

agtctcaatc cttattttaa atgaaaaaag aaaagaaaag cataataaat ttaaaagaaa     2700

aggctgagaa atgaaaaaaa aaaaa                                           2725


<210>  274
<211>  661
<212>  PRT
<213>  Homo Sapiens

<400>  274

Met Ala Phe Asp Val Ser Cys Phe Phe Trp Val Val Leu Phe Ser Ala 
1               5                   10                  15      


Gly Cys Lys Val Ile Thr Ser Trp Asp Gln Met Cys Ile Glu Lys Glu 
            20                  25                  30          


Ala Asn Lys Thr Tyr Asn Cys Glu Asn Leu Gly Leu Ser Glu Ile Pro 
        35                  40                  45              


Asp Thr Leu Pro Asn Thr Thr Glu Phe Leu Glu Phe Ser Phe Asn Phe 
    50                  55                  60                  


Leu Pro Thr Ile His Asn Arg Thr Phe Ser Arg Leu Met Asn Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Leu Thr Arg Cys Gln Ile Asn Trp Ile His Glu Asp Thr 
                85                  90                  95      


Phe Gln Ser His His Gln Leu Ser Thr Leu Val Leu Thr Gly Asn Pro 
            100                 105                 110         


Leu Ile Phe Met Ala Glu Thr Ser Leu Asn Gly Pro Lys Ser Leu Lys 
        115                 120                 125             


His Leu Phe Leu Ile Gln Thr Gly Ile Ser Asn Leu Glu Phe Ile Pro 
    130                 135                 140                 


Val His Asn Leu Glu Asn Leu Glu Ser Leu Tyr Leu Gly Ser Asn His 
145                 150                 155                 160 


Ile Ser Ser Ile Lys Phe Pro Lys Asp Phe Pro Ala Arg Asn Leu Lys 
                165                 170                 175     


Val Leu Asp Phe Gln Asn Asn Ala Ile His Tyr Ile Ser Arg Glu Asp 
            180                 185                 190         


Met Arg Ser Leu Glu Gln Ala Ile Asn Leu Ser Leu Asn Phe Asn Gly 
        195                 200                 205             


Asn Asn Val Lys Gly Ile Glu Leu Gly Ala Phe Asp Ser Thr Ile Phe 
    210                 215                 220                 


Gln Ser Leu Asn Phe Gly Gly Thr Pro Asn Leu Ser Val Ile Phe Asn 
225                 230                 235                 240 


Gly Leu Gln Asn Ser Thr Thr Gln Ser Leu Trp Leu Gly Thr Phe Glu 
                245                 250                 255     


Asp Ile Asp Asp Glu Asp Ile Ser Ser Ala Met Leu Lys Gly Leu Cys 
            260                 265                 270         


Glu Met Ser Val Glu Ser Leu Asn Leu Gln Glu His Arg Phe Ser Asp 
        275                 280                 285             


Ile Ser Ser Thr Thr Phe Gln Cys Phe Thr Gln Leu Gln Glu Leu Asp 
    290                 295                 300                 


Leu Thr Ala Thr His Leu Lys Gly Leu Pro Ser Gly Met Lys Gly Leu 
305                 310                 315                 320 


Asn Leu Leu Lys Lys Leu Val Leu Ser Val Asn His Phe Asp Gln Leu 
                325                 330                 335     


Cys Gln Ile Ser Ala Ala Asn Phe Pro Ser Leu Thr His Leu Tyr Ile 
            340                 345                 350         


Arg Gly Asn Val Lys Lys Leu His Leu Gly Val Gly Cys Leu Glu Lys 
        355                 360                 365             


Leu Gly Asn Leu Gln Thr Leu Asp Leu Ser His Asn Asp Ile Glu Ala 
    370                 375                 380                 


Ser Asp Cys Cys Ser Leu Gln Leu Lys Asn Leu Ser His Leu Gln Thr 
385                 390                 395                 400 


Leu Asn Leu Ser His Asn Glu Pro Leu Gly Leu Gln Ser Gln Ala Phe 
                405                 410                 415     


Lys Glu Cys Pro Gln Leu Glu Leu Leu Asp Leu Ala Phe Thr Arg Leu 
            420                 425                 430         


His Ile Asn Ala Pro Gln Ser Pro Phe Gln Asn Leu His Phe Leu Gln 
        435                 440                 445             


Val Leu Asn Leu Thr Tyr Cys Phe Leu Asp Thr Ser Asn Gln His Leu 
    450                 455                 460                 


Leu Ala Gly Leu Pro Val Leu Arg His Leu Asn Leu Lys Gly Asn His 
465                 470                 475                 480 


Phe Gln Asp Gly Thr Ile Thr Lys Thr Asn Leu Leu Gln Thr Val Gly 
                485                 490                 495     


Ser Leu Glu Val Leu Ile Leu Ser Ser Cys Gly Leu Leu Ser Ile Asp 
            500                 505                 510         


Gln Gln Ala Phe His Ser Leu Gly Lys Met Ser His Val Asp Leu Ser 
        515                 520                 525             


His Asn Ser Leu Thr Cys Asp Ser Ile Asp Ser Leu Ser His Leu Lys 
    530                 535                 540                 


Gly Ile Tyr Leu Asn Leu Ala Ala Asn Ser Ile Asn Ile Ile Ser Pro 
545                 550                 555                 560 


Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Thr Ile Asn Leu Ser His 
                565                 570                 575     


Asn Pro Leu Asp Cys Thr Cys Ser Asn Ile His Phe Leu Thr Trp Tyr 
            580                 585                 590         


Lys Glu Asn Leu His Lys Leu Glu Gly Ser Glu Glu Thr Thr Cys Ala 
        595                 600                 605             


Asn Pro Pro Ser Leu Arg Gly Val Lys Leu Ser Asp Val Lys Leu Ser 
    610                 615                 620                 


Cys Gly Ile Thr Ala Ile Gly Ile Phe Phe Leu Ile Val Phe Leu Leu 
625                 630                 635                 640 


Leu Leu Ala Ile Leu Leu Phe Phe Ala Val Lys Tyr Leu Leu Arg Trp 
                645                 650                 655     


Lys Tyr Gln His Ile 
            660     


<210>  275
<211>  7580
<212>  DNA
<213>  Homo Sapiens

<400>  275
ggcgaggatg gggagcaatg caaagctctg ctcgcccccc atctcacccc ccaagcggat       60

actggtcttc tcgtcggatt gcccatgcac ttgttgcaga aacagccaag gccctggctg      120

tggagaatgc tgaaggaaga agacgcagaa gcaggacgac cctgaaagat tcagcctctt      180

catcctcaaa caggaccagg cctcctcttc ccacctgtcc agcagcatga aagcagcatg      240

attggccgac cgcaggagaa gcccccagaa ccaggccccc aactcagcca tctgcggagg      300

tcaaggtgtg agcgacgtct cctcaccaca gtgctgtgtg gtctatacct cagccaggga      360

gaggatgtga aaccccccgc cctgcacatg agtggtacag gccaacagga acacctggct      420

ccagccacgt tcacagacat gtcagccgtg gagtagtgct gacacttttc tctcagcttc      480

tcagggtttc agtccttttg ggtttgtttt atttaccttt tttatggttt tgtggctgga      540

cgttcacaac caaggcagac agcatgggtg accagcaact gtacaagacc aaccatgtgg      600

cccatggtag tgagaacctt ttctaccaac agccaccact tggcgtccac agcgggctga      660

accacaacta tgggaatgca gttacagggg gcggaatgga tgcccctcag gcctcgccaa      720

tctcccccca cttccctcaa gatacacggg atggtctggg cttgcctgtt ggctccaaaa      780

accttggcca aatggatacc tcgaggcagg gagggtgggg aagtcatgca gggcctggaa      840

accatgtcca gctacgtgga aacctggcca actcaaacat gatgtggggg gcaccagccc      900

aggctgagcc cactgatggc taccaataca cctactccca ggccagcgag atccggaccc      960

agaagcttac cagcggtgtc ttacacaagc tggactcttt cacccaggtg tttgccaacc     1020

aaaacctgcg aattcaggtc aacaatatgg cccaggtgct gcacactcag tcagcagtga     1080

tggatggagc ccctgacagt gctctccgcc agctgctgtc tcagaagccc atggagcccc     1140

cagcaccggc tatcccttcc cgctaccagc aggtgcccca gcagcctcac cctggtttca     1200

ctggtgggct gtccaaacca gctcttcagg tcgggcagca ccctacccaa gggcacctgt     1260

attatgacta ccagcagcct ctggctcagg tgccagtgca gggaggacag ccactgcagg     1320

ccccacagat gctgtcacag cacatgcaac agatgcagca gcaccagtat tacccaccgc     1380

agcaacagca gcaagccggg caacagcgta tctccatgca agaaatacag acgcagccgc     1440

aacaaattcg cccatcacag ccacagccgc cgccacagca gcagcagccg cagcagctac     1500

agctgcagca gcggcagggt tcaatgcaga tacctcagta ttatcagccc caacccatga     1560

tgcagcactt gcaagagcag cagcagcaac agatgcacct gcagcctcct tcttatcaca     1620

gggaccctca ccagtatacc ccagagcagg cacacactgt ccagctgatt cccctgggct     1680

ccatgtccca gtactactac caggagcccc agcagcccta cagccacccc ctctaccagc     1740

agagccacct gtcccagcac cagcagcgtg aggacagtca gctgaagacc tactctagtg     1800

acagacaggc ccaggccatg ctgagctccc atggggacct ggggcctcct gacacaggaa     1860

tgggagaccc agcgagctca gatctgaccc gggtcagcag caccctcccc catcgccccc     1920

tcctatcccc cagtgggatc cacctcaaca acatggggcc tcagcatcag cagctgtctc     1980

ccagtgccat gtggccccag atgcacctac ctgatgggag agcccagcca gggtcccctg     2040

agtcaagtgg ccaacccaaa ggagcgtttg gggagcagtt tgatgccaag aacaagctga     2100

catgctccat ctgcctgaag gagttcaaga acctgcctgc cctgaatggc cacatgcggt     2160

cccacggggg aatgagggcc tcccccaacc tcaaacagga ggaaggagag aaggtcctgc     2220

cgcctcagcc ccagccacca ctgccgcctc cgcctccgcc tccgccgcca ccacagctcc     2280

ctcccgaggc agaaagcctc acgcctatgg tcatgcccgt gtctgtccct gtcaagcttc     2340

tcccgcccaa gcccagctct caggggttca ccaacagcac cgttgccgcc ccctccgcca     2400

gagacaagcc agccagctcg atgtcggacg acgagatgcc tgtgctcgaa atccccagga     2460

agcatcagcc gagtgtgccc aaagccgagg agcccctcaa gaccgtgcag gagaagaaaa     2520

agttccggca ccggccggaa cctctcttca tcccgccgcc gccctcctac aacccgaacc     2580

ccgctgcctc ctactcgggc gccaccctgt accagagcca gctgcgctcc ccgcgcgtcc     2640

tcggggacca cctgctcctg gaccccaccc acgagctgcc cccttacacg cccccaccca     2700

tgctgagccc ggtgcgccag ggctcggggc tcttcagcaa tgtcctcatc tccggccacg     2760

gccctggcgc ccacccgcag ctgcccctga cgcccctgac gcccacacca cgggtgctgc     2820

tgtgtcgctc caacagcatc gatggcagca acgtgacggt caccccaggg cctggagagc     2880

agactgtaga tgttgaacca cgcatcaaca ttggcttgag attccaagca gaaatccctg     2940

aactccaaga tatctctgcc ctggcccagg acacacacaa ggccacactg gtatggaagc     3000

cctggccaga actagaaaac catgacctcc agcaaagagt ggagaatctt ctgaatttgt     3060

gctgttccag tgcattgcca ggtggaggga ccaattctga atttgctttg cactctctgt     3120

ttgaggccaa aggtgatgtg atggttgctc tggaaatgct gctactgcgg aagcctgtca     3180

ggttaaaatg tcatccttta gcaaattacc actatgccgg ttcggacaag tggacctccc     3240

tagaaagaaa actgtttaac aaagcactag ccacttacag caaagacttt atttttgtac     3300

agaagatggt gaagtccaag acggtggctc agtgcgtgga gtactactac acgtggaaaa     3360

agatcatgcg gctggggcgg aaacaccgga cacgcctggc agaaatcatc gacgattgtg     3420

tgacaagtga agaagaagaa gagttagagg aggaggagga ggaggacccg gaagaagata     3480

ggaaatccac aaaagaagaa gagagtgagg tgccgaagtc cccggagcca ccacccgtcc     3540

ccgtcctggc tcccacggag gggccgcccc tgcaggccct gggccagccc tcaggctcct     3600

tcatctgtga aatgcccaac tgtggggctg tgttcagctc ccgacaggca ctgaatggcc     3660

atgcccgcat ccacgggggc accaaccagg tgaccaaggc ccgaggtgcc atcccctctg     3720

ggaagcagaa gcctggtggc acccagagtg ggtactgttc ggtaaagagc tcaccctctc     3780

acagcaccac cagcggcgag acagacccca ccaccatctt cccctgcaag gagtgtggca     3840

aagtcttctt caagatcaaa agccgaaatg cacacatgaa aactcacagg cagcaggagg     3900

aacaacagag gcaaaaggct cagaaggcgg cttttgcagc tgagatggca gccacgattg     3960

agaggactac ggggcccgtg ggggcgccgg ggctgctgcc cctggaccag ctgagtctga     4020

tcaaacccat caaggatgtg gacatcctcg acgacgacgt cgtccagcag ttgggaggtg     4080

tcatggaaga ggctgaagtt gtggacaccg atcttctctt ggatgatcaa gattcagtct     4140

tgcttcaggg tgacgcagaa ctataaagcc ctgtgtgtca cttagagaca gtgaaaaccc     4200

acggcctcca tcttcattaa tcaggaaacc tggactgcct gcttgttttg taaccctttt     4260

aaactacctg ttttaaaagt ggtcatttta ttcaggttta gaaaaaaaaa tcctatttct     4320

tttcctttta tttaaaaaaa tttgtttttg tggggggttg ggggaataaa taattggcac     4380

aactatcttt aagaggtgtt tcatctgggc taccttctca tgaaatcatt cccagtaggg     4440

actgaagctg accttcatgt tccattgcat tcagatgtca accatcccgg ttgcctttta     4500

tcccaaagct tgctgtgagt gtgtgtgtgt gagacgcagg cgaccctctt agtactgggg     4560

tcttggggcc aacttttccc atcaagcgtt actttgattc tgttctgacc tcattccata     4620

gtttgcagtg agcatggcat ctttgcctgg agatactatg ctaggggcag ctttccaggg     4680

gcaaagcaag ccctcgtgtt acacggctct cctccagctc acacgacatg tgaggagatg     4740

accaaatgtg aaaacaggtt tcccctgtgt tgcccgtcat cctttggccc gttcacagga     4800

atggagtact gtataatttt aggctttcat tcccagcagt gtttactgag gacctggttt     4860

tctagaacag gtgtgtcctg tcctcttcca tgttccctgg gggctggtca gctccaagtt     4920

gtgggtggca gagctgtgtt tcagcatgaa ctgactagag acccatctgg aggcaaatat     4980

taagttgcca ggactgcttt cacttcaggg tgattgaagg acacatattg aagtacctag     5040

aatgccagaa agtgttctat tgcccaaaaa acaaatcaga aaagcctatt cttttttgca     5100

acgctgttaa tgattagtgg agttctgaaa ttactttgtg ccacttggaa gtactgtgaa     5160

accgcattca ctgggatttt gctgtaattc acatccgctg gactgaagtt taccttgatg     5220

ttagctataa gaaatagttt tctaacacat acgatagcaa atacaagaca aatagcattg     5280

aaggccaaca aaaatggctt cagatacacc ttagctataa tgtttgcatt caaacaatga     5340

atgtattcat cacaagtcac ttaccaaagc acttctagac ttctccaacc tccatgactt     5400

tgctctgctt cctcctgtcc ctgtcagcag ggttgctgtt tgtacttgaa ggtaataaac     5460

ctgtaatcct tcaaaaatgc catttagccc caggcttctg agctgagtca gactgaccca     5520

tcccaccgtt agggcaaaag tcaggctggg acacagcgcc agtacagaga ggatcctgct     5580

tcatgcaact ccccttttgg agttaatgca gcgtgatttc ctgggccggt gttttcaggc     5640

atcgcccacc ccaggtatgc tggttcccag ctccacgtag gtgtgcctat cacgctgggc     5700

cactttgctg acaacattca tagcttgaca tgagagagaa tatcagcaga agcatgagag     5760

taggacctga cgtctttgac tctgcaaaag catttagcac acactcatgg gggggaactg     5820

gctgtgagcc acagcagccc cacacagaca gtggtctctg aacttcagga aagccatgga     5880

cagaaaaaaa aataaaattc ttttccatca ttctattttc aaagaggtct tggcgttttc     5940

ctacatcttt tgtttagagg gggaaaaaag tttcatttgc tgccatttca gaaaggttat     6000

gctatcctgt tttatccaag cagttgtgag tcaggaactg cctgggcagt gtgcatcaac     6060

tttgtggccg aaccattaca gctgtcatat ccttggctga tcgtctctcc cagggactac     6120

tgccctccac ttagtgtctg agggtaagcc tagaagggtg ctgctattgg gtctatggaa     6180

gcttatctat caaaggagca aacatccaga aaagtgttta taaagcaaat gtattgcctc     6240

tgtttagaga tttgcccagc tgttccagtt ttaaacatta aaaaataaac tcagttgcca     6300

tggcaaaaat agaatgcaca gcttacttat aattttccat gcagtatagc ataaggattt     6360

ttgacttgaa acaaccaaag aactcctcct taacgagaca gttcaaattc ctgaattagt     6420

atttcttgac tatcaactta aagaatggac ttcctagtac aatgttgcac ttattttttt     6480

ttctgaaata attctgcctg catgtatgtg ttgtgtttta gcttctcccc ttaccccacc     6540

ccaaagatct tttcttccta atggttaatg tctcaactcg gttactgttt actatcagat     6600

ggtttttcat tagtgaattt agacctcttt gagaaagctt gtatataaaa agttaacaga     6660

tatattttat ggaaaaaccc atcttatttt caaatatatt taactgctgt tatattttat     6720

tagaggaagg ttgtaaatat tttctaggag ttctattgta aagaaaagta tttttgaaaa     6780

aaattaatgt aataaaaagg aaaacatttt taaatagtgg ttgtgattgc ttcctgttct     6840

ggcttcgtta tgttctattc tcagcagatg aattgcatgc cttccatatc aggatgtaat     6900

ttattcaggt ttgcactatt ataagttgac atcataatat ctagtgtgct taactgtatt     6960

ttcccggaat gcaagtccct tggtccatat taaagcacta tgtatagcat attcataatt     7020

tttcttttgt aacgtgtgta tttttaataa ggattttatg taacattttg gcaacaagag     7080

gaccgtattt tctagtgaat tttataataa cattttgcta aaaatgtttc ttcctaggtc     7140

agtttttgtt aaggtgaacc aaaagtctta ttttaccagg ggtttaaaaa aagtttgaag     7200

cttgaaagca aagttatatt taaacatcat atgtaacaaa taaataaaga tgttttatag     7260

acttgtccta aaaaggtgca ttccttaaaa aaaaaaaaaa gaaaaaaaaa ggaaactggg     7320

gcattctagg ttgtttcccc tccaagtgat aagctttttt tttttcttaa ttatcacaat     7380

gcttcttcaa aaagggaacc agggaaattt tatttaacac attctaatca ttagcctctc     7440

agaaagttat tacagttcct atagatgggc attcatcaaa tggagatgta accaaacaga     7500

cactgtcata tttatttgtg aaaacctgat tcaatattgc atcagctgct ctgaaaataa     7560

aatattaatc ttttgcgttt                                                 7580


<210>  276
<211>  1200
<212>  PRT
<213>  Homo Sapiens

<400>  276

Met Gly Asp Gln Gln Leu Tyr Lys Thr Asn His Val Ala His Gly Ser 
1               5                   10                  15      


Glu Asn Leu Phe Tyr Gln Gln Pro Pro Leu Gly Val His Ser Gly Leu 
            20                  25                  30          


Asn His Asn Tyr Gly Asn Ala Val Thr Gly Gly Gly Met Asp Ala Pro 
        35                  40                  45              


Gln Ala Ser Pro Ile Ser Pro His Phe Pro Gln Asp Thr Arg Asp Gly 
    50                  55                  60                  


Leu Gly Leu Pro Val Gly Ser Lys Asn Leu Gly Gln Met Asp Thr Ser 
65                  70                  75                  80  


Arg Gln Gly Gly Trp Gly Ser His Ala Gly Pro Gly Asn His Val Gln 
                85                  90                  95      


Leu Arg Gly Asn Leu Ala Asn Ser Asn Met Met Trp Gly Ala Pro Ala 
            100                 105                 110         


Gln Ala Glu Pro Thr Asp Gly Tyr Gln Tyr Thr Tyr Ser Gln Ala Ser 
        115                 120                 125             


Glu Ile Arg Thr Gln Lys Leu Thr Ser Gly Val Leu His Lys Leu Asp 
    130                 135                 140                 


Ser Phe Thr Gln Val Phe Ala Asn Gln Asn Leu Arg Ile Gln Val Asn 
145                 150                 155                 160 


Asn Met Ala Gln Val Leu His Thr Gln Ser Ala Val Met Asp Gly Ala 
                165                 170                 175     


Pro Asp Ser Ala Leu Arg Gln Leu Leu Ser Gln Lys Pro Met Glu Pro 
            180                 185                 190         


Pro Ala Pro Ala Ile Pro Ser Arg Tyr Gln Gln Val Pro Gln Gln Pro 
        195                 200                 205             


His Pro Gly Phe Thr Gly Gly Leu Ser Lys Pro Ala Leu Gln Val Gly 
    210                 215                 220                 


Gln His Pro Thr Gln Gly His Leu Tyr Tyr Asp Tyr Gln Gln Pro Leu 
225                 230                 235                 240 


Ala Gln Val Pro Val Gln Gly Gly Gln Pro Leu Gln Ala Pro Gln Met 
                245                 250                 255     


Leu Ser Gln His Met Gln Gln Met Gln Gln His Gln Tyr Tyr Pro Pro 
            260                 265                 270         


Gln Gln Gln Gln Gln Ala Gly Gln Gln Arg Ile Ser Met Gln Glu Ile 
        275                 280                 285             


Gln Thr Gln Pro Gln Gln Ile Arg Pro Ser Gln Pro Gln Pro Pro Pro 
    290                 295                 300                 


Gln Gln Gln Gln Pro Gln Gln Leu Gln Leu Gln Gln Arg Gln Gly Ser 
305                 310                 315                 320 


Met Gln Ile Pro Gln Tyr Tyr Gln Pro Gln Pro Met Met Gln His Leu 
                325                 330                 335     


Gln Glu Gln Gln Gln Gln Gln Met His Leu Gln Pro Pro Ser Tyr His 
            340                 345                 350         


Arg Asp Pro His Gln Tyr Thr Pro Glu Gln Ala His Thr Val Gln Leu 
        355                 360                 365             


Ile Pro Leu Gly Ser Met Ser Gln Tyr Tyr Tyr Gln Glu Pro Gln Gln 
    370                 375                 380                 


Pro Tyr Ser His Pro Leu Tyr Gln Gln Ser His Leu Ser Gln His Gln 
385                 390                 395                 400 


Gln Arg Glu Asp Ser Gln Leu Lys Thr Tyr Ser Ser Asp Arg Gln Ala 
                405                 410                 415     


Gln Ala Met Leu Ser Ser His Gly Asp Leu Gly Pro Pro Asp Thr Gly 
            420                 425                 430         


Met Gly Asp Pro Ala Ser Ser Asp Leu Thr Arg Val Ser Ser Thr Leu 
        435                 440                 445             


Pro His Arg Pro Leu Leu Ser Pro Ser Gly Ile His Leu Asn Asn Met 
    450                 455                 460                 


Gly Pro Gln His Gln Gln Leu Ser Pro Ser Ala Met Trp Pro Gln Met 
465                 470                 475                 480 


His Leu Pro Asp Gly Arg Ala Gln Pro Gly Ser Pro Glu Ser Ser Gly 
                485                 490                 495     


Gln Pro Lys Gly Ala Phe Gly Glu Gln Phe Asp Ala Lys Asn Lys Leu 
            500                 505                 510         


Thr Cys Ser Ile Cys Leu Lys Glu Phe Lys Asn Leu Pro Ala Leu Asn 
        515                 520                 525             


Gly His Met Arg Ser His Gly Gly Met Arg Ala Ser Pro Asn Leu Lys 
    530                 535                 540                 


Gln Glu Glu Gly Glu Lys Val Leu Pro Pro Gln Pro Gln Pro Pro Leu 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Pro Glu Ala 
                565                 570                 575     


Glu Ser Leu Thr Pro Met Val Met Pro Val Ser Val Pro Val Lys Leu 
            580                 585                 590         


Leu Pro Pro Lys Pro Ser Ser Gln Gly Phe Thr Asn Ser Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Ala Arg Asp Lys Pro Ala Ser Ser Met Ser Asp Asp Glu 
    610                 615                 620                 


Met Pro Val Leu Glu Ile Pro Arg Lys His Gln Pro Ser Val Pro Lys 
625                 630                 635                 640 


Ala Glu Glu Pro Leu Lys Thr Val Gln Glu Lys Lys Lys Phe Arg His 
                645                 650                 655     


Arg Pro Glu Pro Leu Phe Ile Pro Pro Pro Pro Ser Tyr Asn Pro Asn 
            660                 665                 670         


Pro Ala Ala Ser Tyr Ser Gly Ala Thr Leu Tyr Gln Ser Gln Leu Arg 
        675                 680                 685             


Ser Pro Arg Val Leu Gly Asp His Leu Leu Leu Asp Pro Thr His Glu 
    690                 695                 700                 


Leu Pro Pro Tyr Thr Pro Pro Pro Met Leu Ser Pro Val Arg Gln Gly 
705                 710                 715                 720 


Ser Gly Leu Phe Ser Asn Val Leu Ile Ser Gly His Gly Pro Gly Ala 
                725                 730                 735     


His Pro Gln Leu Pro Leu Thr Pro Leu Thr Pro Thr Pro Arg Val Leu 
            740                 745                 750         


Leu Cys Arg Ser Asn Ser Ile Asp Gly Ser Asn Val Thr Val Thr Pro 
        755                 760                 765             


Gly Pro Gly Glu Gln Thr Val Asp Val Glu Pro Arg Ile Asn Ile Gly 
    770                 775                 780                 


Leu Arg Phe Gln Ala Glu Ile Pro Glu Leu Gln Asp Ile Ser Ala Leu 
785                 790                 795                 800 


Ala Gln Asp Thr His Lys Ala Thr Leu Val Trp Lys Pro Trp Pro Glu 
                805                 810                 815     


Leu Glu Asn His Asp Leu Gln Gln Arg Val Glu Asn Leu Leu Asn Leu 
            820                 825                 830         


Cys Cys Ser Ser Ala Leu Pro Gly Gly Gly Thr Asn Ser Glu Phe Ala 
        835                 840                 845             


Leu His Ser Leu Phe Glu Ala Lys Gly Asp Val Met Val Ala Leu Glu 
    850                 855                 860                 


Met Leu Leu Leu Arg Lys Pro Val Arg Leu Lys Cys His Pro Leu Ala 
865                 870                 875                 880 


Asn Tyr His Tyr Ala Gly Ser Asp Lys Trp Thr Ser Leu Glu Arg Lys 
                885                 890                 895     


Leu Phe Asn Lys Ala Leu Ala Thr Tyr Ser Lys Asp Phe Ile Phe Val 
            900                 905                 910         


Gln Lys Met Val Lys Ser Lys Thr Val Ala Gln Cys Val Glu Tyr Tyr 
        915                 920                 925             


Tyr Thr Trp Lys Lys Ile Met Arg Leu Gly Arg Lys His Arg Thr Arg 
    930                 935                 940                 


Leu Ala Glu Ile Ile Asp Asp Cys Val Thr Ser Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Leu Glu Glu Glu Glu Glu Glu Asp Pro Glu Glu Asp Arg Lys Ser Thr 
                965                 970                 975     


Lys Glu Glu Glu Ser Glu Val Pro Lys Ser Pro Glu Pro Pro Pro Val 
            980                 985                 990         


Pro Val Leu Ala Pro Thr Glu Gly  Pro Pro Leu Gln Ala  Leu Gly Gln 
        995                 1000                 1005             


Pro Ser  Gly Ser Phe Ile Cys  Glu Met Pro Asn Cys  Gly Ala Val 
    1010                 1015                 1020             


Phe Ser  Ser Arg Gln Ala Leu  Asn Gly His Ala Arg  Ile His Gly 
    1025                 1030                 1035             


Gly Thr  Asn Gln Val Thr Lys  Ala Arg Gly Ala Ile  Pro Ser Gly 
    1040                 1045                 1050             


Lys Gln  Lys Pro Gly Gly Thr  Gln Ser Gly Tyr Cys  Ser Val Lys 
    1055                 1060                 1065             


Ser Ser  Pro Ser His Ser Thr  Thr Ser Gly Glu Thr  Asp Pro Thr 
    1070                 1075                 1080             


Thr Ile  Phe Pro Cys Lys Glu  Cys Gly Lys Val Phe  Phe Lys Ile 
    1085                 1090                 1095             


Lys Ser  Arg Asn Ala His Met  Lys Thr His Arg Gln  Gln Glu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Gln Lys Ala Gln  Lys Ala Ala Phe Ala  Ala Glu Met 
    1115                 1120                 1125             


Ala Ala  Thr Ile Glu Arg Thr  Thr Gly Pro Val Gly  Ala Pro Gly 
    1130                 1135                 1140             


Leu Leu  Pro Leu Asp Gln Leu  Ser Leu Ile Lys Pro  Ile Lys Asp 
    1145                 1150                 1155             


Val Asp  Ile Leu Asp Asp Asp  Val Val Gln Gln Leu  Gly Gly Val 
    1160                 1165                 1170             


Met Glu  Glu Ala Glu Val Val  Asp Thr Asp Leu Leu  Leu Asp Asp 
    1175                 1180                 1185             


Gln Asp  Ser Val Leu Leu Gln  Gly Asp Ala Glu Leu  
    1190                 1195                 1200 


<210>  277
<211>  2592
<212>  DNA
<213>  Homo Sapiens

<400>  277
accactttgt ctaaggcagt tgaggaaggg aagtagatat aatggagctt agtggcagag       60

cagctggaat cctgagagaa gagaataact ttagttcaga gcaggtgggg aaatgagaga      120

ttgagtagga ggaccaaggt tgagggaagc agatcttctt agttgctgtc agcggctgat      180

ggggaagatt gttggtagaa ggaagtcaga atataggtac agagggataa gtttgctaag      240

aacagagatc agcaaacagc ttttctgaga gaaagaaaca tctgcaaatg acatgctgtt      300

tctgcagttt ctgctgctag ctcttcttct cccaggtggt gacaatgcag acgcatccca      360

ggaacacgtc tccttccatg tcatccagat cttctcattt gtcaaccaat cctgggcacg      420

aggtcagggc tcaggatggc tggacgagtt gcagactcat ggctgggaca gtgaatcagg      480

cacaataatt ttcctgcata actggtccaa gggcaacttc agcaatgaag agttgtcaga      540

cctagagttg ttatttcgtt tctacctctt tggattaact cgggagattc aagaccatgc      600

aagtcaagat tactcgaaat atccctttga agtacaggtg aaagcgggct gtgagctgca      660

ttctggaaag agcccagaag gcttctttca ggtagctttc aacggattag atttactgag      720

tttccagaat acaacatggg tgccatctcc aggctgtgga agtttggccc aaagtgtctg      780

tcatctactc aatcatcagt atgaaggcgt cacagaaaca gtgtataatc tcataagaag      840

cacttgcccc cgatttctct tgggtctcct ggatgcaggg aagatgtatg tacacaggca      900

agtgaggcca gaagcctggc tgtccagtcg ccccagcctt gggtctggcc agctgttgct      960

ggtttgtcat gcctccggct tctacccaaa gcctgtttgg gtgacatgga tgcggaatga     1020

acaggagcaa ctgggcacta aacatggtga tattcttcct aatgctgatg ggacatggta     1080

tcttcaggtg atcctggagg tggcatctga ggagcctgct ggcctgtctt gtcgagtgag     1140

acacagcagt ctaggaggcc aggacatcat cctctactgg ggacaccact tttccatgaa     1200

ttggattgcc ttggtagtga tagtgccctt ggtgattcta atagtccttg tgttatggtt     1260

taagaagcac tgctcatatc aggacatcct gtgagactct tccccctgac tcccccattg     1320

tgttaagaac ccagcaaccc aggagcctag tacaatatag tgatgccatc ccgtcgactc     1380

tccatttaaa ttgtttctct ttctgcataa taaacatttg ttaataaaaa ccaaattcta     1440

atttggaatg tttttcttgg aatctccact ttttatatag cactcaacct tcaaagccca     1500

tttctgatgt catttcctcc aacgatcttc cttgacccat actgaaccca gagagcccct     1560

caactgttat gtgcatgcaa cacttcctac cctgtgttgc agctacttga gtctttcatt     1620

tcacattttt aagcttttag gaggcaagga tcatgataaa tgtgcctttc ctgcatatga     1680

taggctcagt gaaacacaaa acaaaacatc atatctaagt tggattaact gtcatgttga     1740

caatttttct cattatattc cttcccaatg ttgttgtagc attggaaata ttcatgcttc     1800

tctttttgtt taaatgcttc atacctagca gataaattcc actctccttt agctccctca     1860

ttttctcctt aaacatttaa ggaaaagtgc agccttgtgc cttgatacac ttattttcta     1920

aacacagaga attacaaatg caaatagaca gagagtgtgc aagttacatg tgatgatcag     1980

tggtgcagat atgtcacaga atacttaaga aaaggaacaa gagatttggt cctcagggtt     2040

ggagtgggat caaggcaacc gttgtgctgt atatggaaga caaatttcct aaaggactgt     2100

gttatctgag atagccttgg ctaaacttta gtccctttag gtttcattca ctaattcaac     2160

taatattttt tgggtactga gttgagacag gcacatacag cttctaaact ggtggtggat     2220

aaaacaaatg agattgtgtc cactctcctg aagttgcaat gtttgcttcc tcaatctgtc     2280

catgtttctt ttctattgtt ttcatgtttt tatttatttc aaaaaatttt aaatagattt     2340

tattgatgta taatttatag taaaatttga atctttaagt gtacagttct atttattttg     2400

ataattatat aagcccatgt aaacaaaatc acaatcaaga tattaaatgt cataacccct     2460

catacctgtt tgtagtcaag cacaccaaca acctggcatt cttgcaacta ctgatatact     2520

ttatgtcact taagcttaaa cttgtatttt ctatgatttt attaagatgg aaataaacat     2580

atctacttgg ta                                                         2592


<210>  278
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  278

Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210>  279
<211>  4140
<212>  DNA
<213>  Homo Sapiens

<400>  279
gaagccagag gctgggggag ctgctggagc ctcgcgaagc cgcggccggc gccctgcgcc       60

gtcgccgccg cctgctagtt tcctccgggt tctcagcccc gggtactgag gcttcggtct      120

ataaatagca ggttacagct cctcctgggc gcgcacacgc tcacacgctc gcaagcgaac      180

gcaggaaagt caggctaaaa gtgtctgctg ctgctgccgc cccccactcc gcctccggga      240

gagaatacaa agaaatggtg ttacctggca agaggtcttc tgtcttttat gaaaaattag      300

acaaaggctt tacaggaggc atagtactgg aaatctgctc ctgatgaggt ctcagaaagc      360

ttccactcgt ggtggaaggc aaaggaggag caggcacatc acatgagcct tgaaaccagc      420

gaaacaataa tcaaagagca gttctgtcaa agaaaacaac ataaatcagg tacagaattt      480

cagagtggga tatcagatct ttagtgtgaa gatacatcta cattaaacca ggaatcacta      540

gaactgacat ttggacaaga aaatttggaa aattttaaaa ctgtgaaggt tgatcatgga      600

aattaaagag gaaggggcat cagaagaagg gcagcacttt cttcctacag cccaggccaa      660

tgatcccggg gactgtcagt tcacaagtat ccagaagact ccaaatgaac cgcagttgga      720

attcatcctt gcatgcaagg atctcgtggc tcctgtccgt gatcgtaaac tgaatacact      780

ggtgcagatc tccgtaatcc accccgtgga gcagagtctg acaagatact ccagcaccga      840

aattgtggag ggaacaaggg acccactgtt tttgactggt gtcacattcc catctgagta      900

tcccatctat gaggagacca aaataaaact aacagtctat gatgtcaagg ataagtctca      960

tgacaccgtt cgaaccagtg tcctaccaga acataaggat cccccgccag aagttgggcg     1020

aagtttcttg ggctatgcca gttttaaagt gggagagctg ctgaagtcaa aggagcaatt     1080

gctggtcctg agcctgagaa cttcagatgg tggcaaagtg gttggcacca tagaagtcag     1140

tgtcgtgaag atgggggaga ttgaggatgg ggaagccgac cacatcacca cagatgtaca     1200

gggacaaaag tgtgccctgg tatgtgaatg tacagccccg gaaagtgtga gcggaaaaga     1260

taacttacct tttttgaatt cagtgttaaa gaacccagta tgtaaattat atagatttcc     1320

cacatctgac aataagtgga tgcgaattcg agagcagatg tcagagagca ttctttcctt     1380

tcatattcct aaggaattga tttcccttca cattaaagaa gatttgtgca gaaaccagga     1440

gataaaagaa cttggtgagc tttctccaca ttgggacaat ctgcgaaaaa atgtccttac     1500

tcactgtgat caaatggtga atatgtacca agacattctg acagaactta gcaaggaaac     1560

agggtcctct ttcaaatcaa gcagcagcaa aggagagaaa acattagaat ttgttccaat     1620

aaatctacat ctgcaaagaa tgcaggtaca cagccctcac ttgaaagatg ctctctacga     1680

tgtcatcact gtgggagccc cagctgccca ttttcaggga tttaagaatg gtggtcttcg     1740

gaagctactc catagatttg aaacagaaag aagaaatacc ggataccagt ttatttacta     1800

ttcacctgaa aacacagcca aagcaaagga agttctcagc aacatcaatc aactacaacc     1860

tcttatagca acccatgcag acctactgct taattctgca agccagcatt ctccagacag     1920

cttgaagaat tctttaaaga tgctttcaga aaaaacagag ctttttgtac atgccttcaa     1980

ggatcaactt gtcaggagtg ctcttttagc actctacact gcaaggccag gaggcattct     2040

taagaagcca ccctctccta agagcagcac agaggagagc agtccccaag accaaccccc     2100

agtgatgaga gggcaggact ccataccaca tcattcagac tatgatgagg aagagtggga     2160

cagggtgtgg gccaatgtgg ggaagagcct gaactgcatt attgctatgg tggacaaact     2220

gattgaaaga gatggtggca gtgaaggcag tggcggcaac aatgatggag aaaaggaacc     2280

ttcattaaca gatgccattc cctctcaccc aagagaggac tggtatgaac agttgtatcc     2340

cctcatcctt accctgaagg actgcatggg agaagtggtg aaccgagcca agcagtccct     2400

gacatttgtg ctccttcagg aacttgcgta cagcttgccc cagtgtctga tgctgacgct     2460

aagaagagac atcgtcttca gccaagcact tgctggattg gtttgtggtt ttatcatcaa     2520

attacagaca agtctgtatg acccaggctt cctacagcag cttcacacag tggggttgat     2580

agtacaatat gaaggactgc taagtacata cagcgatgaa attggaatgc tagaggacat     2640

ggccgttggc atttccgatt taaagaaagt tgcatttaaa ataattgaag ccaaatccaa     2700

tgatgtgttg ccagttataa caggaagacg agaacattac gtggtagagg tcaagcttcc     2760

agccagaatg tttgagtcac tacctctaca gattaaagaa ggacagttgc ttcatgtgta     2820

tccagtactt tttaatgttg gaatcaatga acagcaaact ctggctgaaa ggtttggaga     2880

tgtctctttg caagaaagta ttaatcagga aaacttcgaa cttctacaag aatattacaa     2940

gatatttatg gaaaagatgc ctcctgatta tatttcacat tttcaggaac aaaatgattt     3000

aaaagcattg ctagaaaatc tccttcaaaa tatccaatcc aaaaaaagaa agaatgtaga     3060

aattatgtgg ctggctgcaa cgatttgccg caaactgaat ggtattcgtt tcacctgttg     3120

taaaagtgcc aaagacagga catcgatgtc agtgacactt gaacaatgct caatcttgag     3180

agatgagcac cagttacaca aggacttctt tatccgagcg ctggattgca tgagaagaga     3240

aggatgccgc atagagaatg tactgaagaa tatcaaatgc agaaagtatg ctttcaacat     3300

gctacagctg atggctttcc ccaagtacta cagacctcca gaggggactt atggaaaagc     3360

tgacacctaa gtttaccaac atgttaataa acaggaacac aaatacattt cagttggata     3420

atcttcacct tggtcttttt tgtttgtttt tattgtcatg aatttgtggt gggggagatg     3480

atcacagatg tttcccaaaa tctaggaact acttcaattc atcatcagca tattgctctg     3540

aaagaaatcc attttaaaaa atcttacatg attcagtact gtcatttcta gttctaagct     3600

tctatgtgtt gagcctagct gattgagatt ggttcacaaa gtgtaaattt cattcatgag     3660

tatttaaatg tttctgagga aacatggatc atttcaatag gactaggggt gattcacaga     3720

gcaccactct ccaaccaaat ggaagagagg agagggggaa aaggaacata ttttttttgt     3780

gatacaactt aatagcctat gagaacacag tcaacctgag aatcaatgta agggatttaa     3840

aaaaaatgtg tagccactca attaggtaga gttaactcat gatctggaat actgaggcag     3900

tttgcaggta tgttccacaa tgatctctat catccagtca aggtgtgact cctcccttgc     3960

aacaggcata tgcatggagt gagtaaagtg gtcaacagac ctttcaaaac catggcatct     4020

tttcagaact ctgacttggg ttgtgtgatc tagctgtgaa tgtagcaata tagaacgttt     4080

aatagaatga taagcaaaac actgcaatga tctaaaatta caaaaaaaaa aaaaaaaaaa     4140


<210>  280
<211>  924
<212>  PRT
<213>  Homo Sapiens

<400>  280

Met Glu Ile Lys Glu Glu Gly Ala Ser Glu Glu Gly Gln His Phe Leu 
1               5                   10                  15      


Pro Thr Ala Gln Ala Asn Asp Pro Gly Asp Cys Gln Phe Thr Ser Ile 
            20                  25                  30          


Gln Lys Thr Pro Asn Glu Pro Gln Leu Glu Phe Ile Leu Ala Cys Lys 
        35                  40                  45              


Asp Leu Val Ala Pro Val Arg Asp Arg Lys Leu Asn Thr Leu Val Gln 
    50                  55                  60                  


Ile Ser Val Ile His Pro Val Glu Gln Ser Leu Thr Arg Tyr Ser Ser 
65                  70                  75                  80  


Thr Glu Ile Val Glu Gly Thr Arg Asp Pro Leu Phe Leu Thr Gly Val 
                85                  90                  95      


Thr Phe Pro Ser Glu Tyr Pro Ile Tyr Glu Glu Thr Lys Ile Lys Leu 
            100                 105                 110         


Thr Val Tyr Asp Val Lys Asp Lys Ser His Asp Thr Val Arg Thr Ser 
        115                 120                 125             


Val Leu Pro Glu His Lys Asp Pro Pro Pro Glu Val Gly Arg Ser Phe 
    130                 135                 140                 


Leu Gly Tyr Ala Ser Phe Lys Val Gly Glu Leu Leu Lys Ser Lys Glu 
145                 150                 155                 160 


Gln Leu Leu Val Leu Ser Leu Arg Thr Ser Asp Gly Gly Lys Val Val 
                165                 170                 175     


Gly Thr Ile Glu Val Ser Val Val Lys Met Gly Glu Ile Glu Asp Gly 
            180                 185                 190         


Glu Ala Asp His Ile Thr Thr Asp Val Gln Gly Gln Lys Cys Ala Leu 
        195                 200                 205             


Val Cys Glu Cys Thr Ala Pro Glu Ser Val Ser Gly Lys Asp Asn Leu 
    210                 215                 220                 


Pro Phe Leu Asn Ser Val Leu Lys Asn Pro Val Cys Lys Leu Tyr Arg 
225                 230                 235                 240 


Phe Pro Thr Ser Asp Asn Lys Trp Met Arg Ile Arg Glu Gln Met Ser 
                245                 250                 255     


Glu Ser Ile Leu Ser Phe His Ile Pro Lys Glu Leu Ile Ser Leu His 
            260                 265                 270         


Ile Lys Glu Asp Leu Cys Arg Asn Gln Glu Ile Lys Glu Leu Gly Glu 
        275                 280                 285             


Leu Ser Pro His Trp Asp Asn Leu Arg Lys Asn Val Leu Thr His Cys 
    290                 295                 300                 


Asp Gln Met Val Asn Met Tyr Gln Asp Ile Leu Thr Glu Leu Ser Lys 
305                 310                 315                 320 


Glu Thr Gly Ser Ser Phe Lys Ser Ser Ser Ser Lys Gly Glu Lys Thr 
                325                 330                 335     


Leu Glu Phe Val Pro Ile Asn Leu His Leu Gln Arg Met Gln Val His 
            340                 345                 350         


Ser Pro His Leu Lys Asp Ala Leu Tyr Asp Val Ile Thr Val Gly Ala 
        355                 360                 365             


Pro Ala Ala His Phe Gln Gly Phe Lys Asn Gly Gly Leu Arg Lys Leu 
    370                 375                 380                 


Leu His Arg Phe Glu Thr Glu Arg Arg Asn Thr Gly Tyr Gln Phe Ile 
385                 390                 395                 400 


Tyr Tyr Ser Pro Glu Asn Thr Ala Lys Ala Lys Glu Val Leu Ser Asn 
                405                 410                 415     


Ile Asn Gln Leu Gln Pro Leu Ile Ala Thr His Ala Asp Leu Leu Leu 
            420                 425                 430         


Asn Ser Ala Ser Gln His Ser Pro Asp Ser Leu Lys Asn Ser Leu Lys 
        435                 440                 445             


Met Leu Ser Glu Lys Thr Glu Leu Phe Val His Ala Phe Lys Asp Gln 
    450                 455                 460                 


Leu Val Arg Ser Ala Leu Leu Ala Leu Tyr Thr Ala Arg Pro Gly Gly 
465                 470                 475                 480 


Ile Leu Lys Lys Pro Pro Ser Pro Lys Ser Ser Thr Glu Glu Ser Ser 
                485                 490                 495     


Pro Gln Asp Gln Pro Pro Val Met Arg Gly Gln Asp Ser Ile Pro His 
            500                 505                 510         


His Ser Asp Tyr Asp Glu Glu Glu Trp Asp Arg Val Trp Ala Asn Val 
        515                 520                 525             


Gly Lys Ser Leu Asn Cys Ile Ile Ala Met Val Asp Lys Leu Ile Glu 
    530                 535                 540                 


Arg Asp Gly Gly Ser Glu Gly Ser Gly Gly Asn Asn Asp Gly Glu Lys 
545                 550                 555                 560 


Glu Pro Ser Leu Thr Asp Ala Ile Pro Ser His Pro Arg Glu Asp Trp 
                565                 570                 575     


Tyr Glu Gln Leu Tyr Pro Leu Ile Leu Thr Leu Lys Asp Cys Met Gly 
            580                 585                 590         


Glu Val Val Asn Arg Ala Lys Gln Ser Leu Thr Phe Val Leu Leu Gln 
        595                 600                 605             


Glu Leu Ala Tyr Ser Leu Pro Gln Cys Leu Met Leu Thr Leu Arg Arg 
    610                 615                 620                 


Asp Ile Val Phe Ser Gln Ala Leu Ala Gly Leu Val Cys Gly Phe Ile 
625                 630                 635                 640 


Ile Lys Leu Gln Thr Ser Leu Tyr Asp Pro Gly Phe Leu Gln Gln Leu 
                645                 650                 655     


His Thr Val Gly Leu Ile Val Gln Tyr Glu Gly Leu Leu Ser Thr Tyr 
            660                 665                 670         


Ser Asp Glu Ile Gly Met Leu Glu Asp Met Ala Val Gly Ile Ser Asp 
        675                 680                 685             


Leu Lys Lys Val Ala Phe Lys Ile Ile Glu Ala Lys Ser Asn Asp Val 
    690                 695                 700                 


Leu Pro Val Ile Thr Gly Arg Arg Glu His Tyr Val Val Glu Val Lys 
705                 710                 715                 720 


Leu Pro Ala Arg Met Phe Glu Ser Leu Pro Leu Gln Ile Lys Glu Gly 
                725                 730                 735     


Gln Leu Leu His Val Tyr Pro Val Leu Phe Asn Val Gly Ile Asn Glu 
            740                 745                 750         


Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Val Ser Leu Gln Glu Ser 
        755                 760                 765             


Ile Asn Gln Glu Asn Phe Glu Leu Leu Gln Glu Tyr Tyr Lys Ile Phe 
    770                 775                 780                 


Met Glu Lys Met Pro Pro Asp Tyr Ile Ser His Phe Gln Glu Gln Asn 
785                 790                 795                 800 


Asp Leu Lys Ala Leu Leu Glu Asn Leu Leu Gln Asn Ile Gln Ser Lys 
                805                 810                 815     


Lys Arg Lys Asn Val Glu Ile Met Trp Leu Ala Ala Thr Ile Cys Arg 
            820                 825                 830         


Lys Leu Asn Gly Ile Arg Phe Thr Cys Cys Lys Ser Ala Lys Asp Arg 
        835                 840                 845             


Thr Ser Met Ser Val Thr Leu Glu Gln Cys Ser Ile Leu Arg Asp Glu 
    850                 855                 860                 


His Gln Leu His Lys Asp Phe Phe Ile Arg Ala Leu Asp Cys Met Arg 
865                 870                 875                 880 


Arg Glu Gly Cys Arg Ile Glu Asn Val Leu Lys Asn Ile Lys Cys Arg 
                885                 890                 895     


Lys Tyr Ala Phe Asn Met Leu Gln Leu Met Ala Phe Pro Lys Tyr Tyr 
            900                 905                 910         


Arg Pro Pro Glu Gly Thr Tyr Gly Lys Ala Asp Thr 
        915                 920                 


<210>  281
<211>  5069
<212>  DNA
<213>  Homo Sapiens

<400>  281
gaggcggagg cggccccggg ctcgggcggc tgggatggag cagaagagcg cggagcaccg       60

gagggcacgc agctgacgga gctgcgctgc gttcgcctcg tttgcctcgc gccctccact      120

ggagctgttc gcgcctcccg gctcccaccg cagcccaccc ggcagaggag tcgctaccag      180

cgcccagtgc gctctgtcag tccgcaaact ccttgccgcc cgccccgggc tgggcaccaa      240

ataccaggct accatggtct acaagactct cttcgctctt tgcatcttaa ctgcaggatg      300

gagggtacag agtctgccta catcagctcc tttgtctgtt tctcttccga caaacattgt      360

accaccgacc accatctgga ctagctctcc acaaaacact gatgcagaca ctgcctcccc      420

atccaacggc actcacaaca actcggtgct cccagttaca gcatcagccc caacatctct      480

gcttcctaag aacatttcca tagagtccag agaagaggag atcaccagcc caggttcgaa      540

ttgggaaggc acaaacacag acccctcacc ttctgggttc tcgtcaacaa gcggtggagt      600

ccacttaaca accacgttgg aggaacacag ctcgggcact cctgaagcag gcgtggcagc      660

tacactgtcg cagtccgctg ctgagcctcc cacactcatc tcccctcaag ctccagcctc      720

atcaccctca tccctatcaa cctcaccacc tgaggtcttt tctgcctccg ttactaccaa      780

ccatagctcc actgtgacca gcacccaacc cactggagct ccaactgcac cagagtcccc      840

gacagaggag tccagctctg accacacacc cacttcacat gccacagctg agccagtacc      900

ccaggagaaa acacccccaa caactgtgtc aggcaaagtg atgtgtgagc tcatagacat      960

ggagaccacc accacctttc ccagggtgat catgcaggaa gtagaacatg cattaagttc     1020

aggcagcatc gccgccatta ccgtgacagt cattgccgtg gtgctgctgg tgtttggagt     1080

tgcagcctac ctaaaaatca ggcattcctc ctatggaaga cttttggacg accatgacta     1140

cgggtcctgg ggaaactaca acaaccctct gtacgatgac tcctaacaat ggaatatggc     1200

ctgggatgag gattaactgt tctttattta taagtgctta tccagtagaa ttaataagta     1260

cctgatgcgc attgaacgac aatcttaagc cctgttttgt tggtatggtt gtttttgttt     1320

tcctccctct cctctggctg ctacaacttc ccctttctgg tacaagaaga accattcttt     1380

aaaggtgagt ggaggctgat ttgcagctga agtgggccag ccttgcacca gccaggccag     1440

accaccatgg tgaaggcttc tttccccact gcaggaccca ctttgagaag gaccgaggag     1500

gaggatttgg gttgttttgt taggggttac tttcagggga acatttcatt tgtgttattt     1560

cttaaacttc tatttaggaa attacattaa gtattaatga ggggaaagga aatgagctct     1620

acgaggattt caccctgcat gggagagagc agggttttct cagattcctt tttaatctct     1680

atttatctgg ttgtttctga caggatgctg cctgcttggc tctacaagct ggaaagcagc     1740

ttcttagctg cctaattaat gaaagatgaa aataggaagt gccctggagg gggccagcag     1800

gtcacggggc agaatctctc aggttgctgt gggatctcag tgtgccccta cctgttctcc     1860

cctccaggcc acctgtctct gtaaaggatg tctgctctgt tcaaaaggca gctgggatcc     1920

cagcccacaa gtgatcagca gagttgcatt tccaaagaaa aaggctatga gatgagctga     1980

gttatagaga gaaagggaga ggcatgtacg gtgtggggaa gtggaagaga agctggcggg     2040

ggagaaggag gctaacctgc actgagtact tcattaggac aagtgagaat cagctattga     2100

taatggccag agatatccac agcttggagg agcccagaga ccgtttgctt tatacccaca     2160

cagcaactgg tccactgctt tactgtctgt tggataatgg ctgtaaaatg tttaaaaaca     2220

aaacaaaaca aaaaagaggc actagtctat ctgcaattac tcaacgaggc attttcatag     2280

gaaacagact atgattaatc catttattct tcccacacac ttaccttact aagtctttgc     2340

tttaataaat gagcaaccct gggtatagtc ttaaaattct gcacaataaa ttttgagaaa     2400

gaattgttcc tctttgtagg tatctgtgta ttgcaatcat tctcaaccag gaggtgattt     2460

tgccccctga ctccacccca gggacattca aaaatgtctg gtgacagttt tcattgtcat     2520

gacttggggg tgctactaga agccaggaat gctgccaaac attctaccat gcacagcaca     2580

acctacaaca gcaaagaatc atccacccca aaatatcagt agtgccgaga ttgagaaacc     2640

ctgatttatc acaatgccca ctgtgacaga acaagacact cacagattag tgatacgttt     2700

tatttttaac aaaatgaaat gatgtgttaa gtttttattt ccaaagtgtt tagtttattg     2760

gctgatgggt tgttcttggt atgcatggtg acctttttat ttctgtgtgc ttcctagaga     2820

gctttatttc atggcgacaa ctctgtcttc ttgtaacagc tgatattagc aagcagcatc     2880

ttatgtcctg atttcatata gtagaaaaca aacattgggt ccgacttcaa aatgtgttgt     2940

attgtcctac agtgtcataa agaacctgaa aatgaacttt tgtttctaaa gttggacctt     3000

gctgccatga ctgtttagtt tacagaaact tgaccccggc tcatcctgtc tctggctgtg     3060

gcccggcaaa gcactgaaaa cccctctggt ctcagagaca gtaggggcag tgccactttc     3120

tacaacctgc caacccacac actggagtaa ttctgaaaaa aattattcct aaactctcta     3180

agtgtggacg gagaatgagc aagccccaga agtattttac aaccagagtg ggtaatgagg     3240

agggggctta ctggaatcgt catatctctg aatattgaaa acaacaacta aaaaagtgga     3300

ccttctcaga aaaaaagggc agcaaatgac caagggcgcc ccttctggcc gtgcttggct     3360

tgagtaactg tctctctttc cccaccccca tcacagggct ttcagtttgg caaaggaaaa     3420

gcagataaaa acagaacatt ccatatgttt ctttctccat cggccaaaaa cattttgaca     3480

caatgtttgt gaaacacctt tggagaggtg cacttctgaa tgctgcctct gccgtaaatc     3540

ctggggcaag ggatcagcct cttcccagga accatcgcct tctataaacc gtgaactcaa     3600

gcaggcattt tttttttctt accgaaaggc tgctattgtg caagggcaca taatgggtct     3660

gttgctctta ttggcttcca aatgtgcatg gcaaagagag agatgtgggc ctagagcaga     3720

tatattcagc aaggtgacag cttcccataa caattctaac acttcttatc ttatgtgaga     3780

ataaaatatt taagggttga accttatttt gccaaatgta tcttttctgc ttttgaattg     3840

ggcagaagat tttagcaact atattctaca aatgttactt ataacacaca cacacacatc     3900

tgaaatatat gccgaaaatt gacgtctttg acctcaggga gagcacctgt ccaggtctgc     3960

ctaaaggaaa tggctccagt gggtctaaac aaccacatcc tatccatgga taggtctagt     4020

cataacactt tagagagaat gtcagagcag gagggaggca agccgcctct tctcggccat     4080

cgactgcaga tgatgaaaga gcgggattca actttgtttt cttttcctgt ggccccagtg     4140

aaacctcctg ccctccctgc acgtctgtgt cttcatttct aaaatggggg tgatgctttc     4200

atattgacct caccccatac tacctcacag atgtgttgtg aggattaata aaattatgtc     4260

tatggtattt tcagtttctg gagaaaaata cttatagaca gtttaactat tacatagata     4320

tataagtgat ctcagtttct tgtttgctgt gatactaatg tgttgtttta acttattcca     4380

taaaatgaca gttgtgtcct agccacatca gacagctatc taagctctgg actacccctt     4440

tgtgcagctg aatcactgca gggttgacca tgcctggtgc cacagccatg gtttccattt     4500

ctagatgaaa ggatggccta ggacataggt ctcaaagact cttggatcag aatcaggaga     4560

ttagggaaaa caggatggat acctgagcac taacagcagt agacgtagac ctctgtcctt     4620

taccatctga ggtcttctgg attctttgtg gggttaattt tgatttgatg tcatctgttt     4680

gcccttcatc ttgcttgcaa gtgtgcatgg ttcaatccct cacatccagg aaatgaattt     4740

tgcaattggg ccagatgcta atttgcacgt tgattcacct tctttgcctt taagcctttt     4800

ttttcttttt tttttttttg gcaaatgaat gtaccatttc aactttgatt ttaatagtgc     4860

tagttgatat tggtaataat gctaaccaag agatcaatgc cagatttttc tcttggggta     4920

agttagctga agtcatttaa agatggaaag gtgggaaaat tctttgatat ttgatgtcat     4980

tgtatccaca tttgttgtaa gacatattgc ataccaatta taattatatc aattaaagtt     5040

gataaaagct tccaaaaaaa aaaaaaaaa                                       5069


<210>  282
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  282

Met Val Tyr Lys Thr Leu Phe Ala Leu Cys Ile Leu Thr Ala Gly Trp 
1               5                   10                  15      


Arg Val Gln Ser Leu Pro Thr Ser Ala Pro Leu Ser Val Ser Leu Pro 
            20                  25                  30          


Thr Asn Ile Val Pro Pro Thr Thr Ile Trp Thr Ser Ser Pro Gln Asn 
        35                  40                  45              


Thr Asp Ala Asp Thr Ala Ser Pro Ser Asn Gly Thr His Asn Asn Ser 
    50                  55                  60                  


Val Leu Pro Val Thr Ala Ser Ala Pro Thr Ser Leu Leu Pro Lys Asn 
65                  70                  75                  80  


Ile Ser Ile Glu Ser Arg Glu Glu Glu Ile Thr Ser Pro Gly Ser Asn 
                85                  90                  95      


Trp Glu Gly Thr Asn Thr Asp Pro Ser Pro Ser Gly Phe Ser Ser Thr 
            100                 105                 110         


Ser Gly Gly Val His Leu Thr Thr Thr Leu Glu Glu His Ser Ser Gly 
        115                 120                 125             


Thr Pro Glu Ala Gly Val Ala Ala Thr Leu Ser Gln Ser Ala Ala Glu 
    130                 135                 140                 


Pro Pro Thr Leu Ile Ser Pro Gln Ala Pro Ala Ser Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Thr Ser Pro Pro Glu Val Phe Ser Ala Ser Val Thr Thr Asn 
                165                 170                 175     


His Ser Ser Thr Val Thr Ser Thr Gln Pro Thr Gly Ala Pro Thr Ala 
            180                 185                 190         


Pro Glu Ser Pro Thr Glu Glu Ser Ser Ser Asp His Thr Pro Thr Ser 
        195                 200                 205             


His Ala Thr Ala Glu Pro Val Pro Gln Glu Lys Thr Pro Pro Thr Thr 
    210                 215                 220                 


Val Ser Gly Lys Val Met Cys Glu Leu Ile Asp Met Glu Thr Thr Thr 
225                 230                 235                 240 


Thr Phe Pro Arg Val Ile Met Gln Glu Val Glu His Ala Leu Ser Ser 
                245                 250                 255     


Gly Ser Ile Ala Ala Ile Thr Val Thr Val Ile Ala Val Val Leu Leu 
            260                 265                 270         


Val Phe Gly Val Ala Ala Tyr Leu Lys Ile Arg His Ser Ser Tyr Gly 
        275                 280                 285             


Arg Leu Leu Asp Asp His Asp Tyr Gly Ser Trp Gly Asn Tyr Asn Asn 
    290                 295                 300                 


Pro Leu Tyr Asp Asp Ser 
305                 310 


<210>  283
<211>  2094
<212>  DNA
<213>  Homo Sapiens

<400>  283
gcggaggcag aggcggaggc ggcacccagg ggccggggca ggggaggccg ggaccatcgc       60

agtgacaatt tattttcctg cagcagcggc agcagggacg gttgctgcag gttcggggtc      120

ggccggcctg cgcgtgggct tgcgaggacg ctgttcgtcc cctgcgctgg ggtgtccgac      180

agcgaggagg agaacgacgc acggagcccg cgcgactgga accagcaaag ctccatctgt      240

cggcagagga gaagggggag gaggcacggc cgaggcaaac gagcggacgc ctcgtcgccg      300

ggtgccggta tcaccccgct gcaacgcctt ccagcaaaag ccaccgcggc ccgggttgca      360

gcagccggac ggatgccaag gccacacggc agccacgggg gcagccgtcg cagtcgccgt      420

cccacacggg ctgcggacac caagggttgc taatgaagtg attgagaaga aacagtgaac      480

atcctcattt cacagataag acaacatgga tcagcctttt actgtgaatt ctctgaaaaa      540

gttagctgct atgcctgacc atacagatgt ttccctaagc ccagaagagc gagtccgtgc      600

cctaagcaag cttggttgta atatcaccat cagtgaagac atcactccac gacgttactt      660

taggtctgga gtagagatgg agaggatggc gtctgtgtat ttggaagaag gaaatttgga      720

aaatgccttt gttctttata ataaatttat aaccttattt gtagaaaagc ttcctaacca      780

tcgagattac cagcaatgtg cagtacctga aaagcaggat attatgaaga aactgaagga      840

gattgcattc ccaaggacag atgaattgaa aaacgacctt ttaaagaaat ataacgtaga      900

ataccaagaa tatttgcaaa gcaaaaacaa atataaagct gaaattctca aaaaattgga      960

gcatcagaga ttgatagagg cagaaaggaa gcggattgct cagatgcgcc agcagcagct     1020

agaatcggag cagtttctgt ttttcgaaga tcaactcaag aagcaagagt tagcccgagg     1080

tcaaatgcga agtcagcaaa cctcagggct gtcagagcag attgatggga gcgctttgtc     1140

ctgcttttcc acacaccaga acaattcctt gctgaatgta tttgcagatc aacctaataa     1200

aagtgatgca accaattatg ctagccactc tcctcctgta aacagggcct taacgccagc     1260

tgctactcta agtgctgttc agaatttagt ggttgaagga ctgcgatgtg tagttttgcc     1320

agaagatctt tgccacaaat ttctgcaact ggcagaatct aatacagtga gaggaataga     1380

aacctgtgga atactctgtg gaaaactgac acataatgaa tttactatta cccatgtaat     1440

tgtgccaaag cagtctgcgg gaccagacta ttgtgacatg gagaatgtag aggaattatt     1500

caatgttcag gatcaacatg atctcctcac tctaggatgg atccatacac atcccactca     1560

aactgcattt ttatccagcg ttgatcttca cactcactgt tcctatcaac tcatgttgcc     1620

agaggccatt gccattgttt gctcaccaaa gcataaagac actggcatct tcaggctcac     1680

caatgctggc atgcttgagg tttctgcttg taaaaaaaag ggctttcatc cacacaccaa     1740

ggagcccagg ctgttcagta tatgcaaaca tgtgttggta aaagacataa aaataattgt     1800

gttggatctg aggtgatatg ttctgaatgt aagcaccgtc aacatcagac acctactcat     1860

ggacatgtgg ttgccggatt ttcttaagat gtttccagaa atgactgata ttttatattt     1920

atacatttta gatgacaaag cttgatattt attgctgttg cacattttaa agttttcttt     1980

ttgggttgct ctgtgtcaag agaggttaca tggtgttaaa tcggtacctg ataatgtacc     2040

caaatactat ggccagataa taaattgtgc tgcaaacaac atgtcttgta ttta           2094


<210>  284
<211>  436
<212>  PRT
<213>  Homo Sapiens

<400>  284

Met Asp Gln Pro Phe Thr Val Asn Ser Leu Lys Lys Leu Ala Ala Met 
1               5                   10                  15      


Pro Asp His Thr Asp Val Ser Leu Ser Pro Glu Glu Arg Val Arg Ala 
            20                  25                  30          


Leu Ser Lys Leu Gly Cys Asn Ile Thr Ile Ser Glu Asp Ile Thr Pro 
        35                  40                  45              


Arg Arg Tyr Phe Arg Ser Gly Val Glu Met Glu Arg Met Ala Ser Val 
    50                  55                  60                  


Tyr Leu Glu Glu Gly Asn Leu Glu Asn Ala Phe Val Leu Tyr Asn Lys 
65                  70                  75                  80  


Phe Ile Thr Leu Phe Val Glu Lys Leu Pro Asn His Arg Asp Tyr Gln 
                85                  90                  95      


Gln Cys Ala Val Pro Glu Lys Gln Asp Ile Met Lys Lys Leu Lys Glu 
            100                 105                 110         


Ile Ala Phe Pro Arg Thr Asp Glu Leu Lys Asn Asp Leu Leu Lys Lys 
        115                 120                 125             


Tyr Asn Val Glu Tyr Gln Glu Tyr Leu Gln Ser Lys Asn Lys Tyr Lys 
    130                 135                 140                 


Ala Glu Ile Leu Lys Lys Leu Glu His Gln Arg Leu Ile Glu Ala Glu 
145                 150                 155                 160 


Arg Lys Arg Ile Ala Gln Met Arg Gln Gln Gln Leu Glu Ser Glu Gln 
                165                 170                 175     


Phe Leu Phe Phe Glu Asp Gln Leu Lys Lys Gln Glu Leu Ala Arg Gly 
            180                 185                 190         


Gln Met Arg Ser Gln Gln Thr Ser Gly Leu Ser Glu Gln Ile Asp Gly 
        195                 200                 205             


Ser Ala Leu Ser Cys Phe Ser Thr His Gln Asn Asn Ser Leu Leu Asn 
    210                 215                 220                 


Val Phe Ala Asp Gln Pro Asn Lys Ser Asp Ala Thr Asn Tyr Ala Ser 
225                 230                 235                 240 


His Ser Pro Pro Val Asn Arg Ala Leu Thr Pro Ala Ala Thr Leu Ser 
                245                 250                 255     


Ala Val Gln Asn Leu Val Val Glu Gly Leu Arg Cys Val Val Leu Pro 
            260                 265                 270         


Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu Ser Asn Thr Val 
        275                 280                 285             


Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu Thr His Asn 
    290                 295                 300                 


Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln Ser Ala Gly Pro 
305                 310                 315                 320 


Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe Asn Val Gln Asp 
                325                 330                 335     


Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr His Pro Thr Gln 
            340                 345                 350         


Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys Ser Tyr Gln 
        355                 360                 365             


Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser Pro Lys His Lys 
    370                 375                 380                 


Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met Leu Glu Val Ser 
385                 390                 395                 400 


Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys Glu Pro Arg Leu 
                405                 410                 415     


Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile Lys Ile Ile Val 
            420                 425                 430         


Leu Asp Leu Arg 
        435     


<210>  285
<211>  3059
<212>  DNA
<213>  Homo Sapiens

<400>  285
tcctctgcgt cccgccccgg gagtggctgc gaggctaggc gagccgggaa agggggcgcc       60

gcccagcccc gagccccgcg ccccgtgccc cgagcccgga gccccctgcc cgccgcggca      120

ccatgcgcgc cgagccggcg tgaccggctc cgcccgcggc cgccccgcag ctagcccggc      180

gctctcgccg gccacacgga gcggcgcccg ggagctatga gccatgaagc cgcccggcag      240

cagctcgcgg cagccgcccc tggcgggctg cagccttgcc ggcgcttcct gcggccccca      300

acgcggcccc gccggctcgg tgcctgccag cgccccggcc cgcacgccgc cctgccgcct      360

gcttctcgtc cttctcctgc tgcctccgct cgccgcctcg tcccggcccc gcgcctgggg      420

ggctgctgcg cccagcgctc cgcattggaa tgaaactgca gaaaaaaatt tgggagtcct      480

ggcagatgaa gacaatacat tgcaacagaa tagcagcagt aatatcagtt acagcaatgc      540

aatgcagaaa gaaatcacac tgccttcaag actcatatat tacatcaacc aagactcgga      600

aagcccttat cacgttcttg acacaaaggc aagacaccag caaaaacata ataaggctgt      660

ccatctggcc caggcaagct tccagattga agccttcggc tccaaattca ttcttgacct      720

catactgaac aatggtttgt tgtcttctga ttatgtggag attcactacg aaaatgggaa      780

accacagtac tctaagggtg gagagcactg ttactaccat ggaagcatca gaggcgtcaa      840

agactccaag gtggctctgt caacctgcaa tggacttcat ggcatgtttg aagatgatac      900

cttcgtgtat atgatagagc cactagagct ggttcatgat gagaaaagca caggtcgacc      960

acatataatc cagaaaacct tggcaggaca gtattctaag caaatgaaga atctcactat     1020

ggaaagaggt gaccagtggc cctttctctc tgaattacag tggttgaaaa gaaggaagag     1080

agcagtgaat ccatcacgtg gtatatttga agaaatgaaa tatttggaac ttatgattgt     1140

taatgatcac aaaacgtata agaagcatcg ctcttctcat gcacatacca acaactttgc     1200

aaagtccgtg gtcaaccttg tggattctat ttacaaggag cagctcaaca ccagggttgt     1260

cctggtggct gtagagacct ggactgagaa ggatcagatt gacatcacca ccaaccctgt     1320

gcagatgctc catgagttct caaaataccg gcagcgcatt aagcagcatg ctgatgctgt     1380

gcacctcatc tcgcgggtga catttcacta taagagaagc agtctgagtt actttggagg     1440

tgtctgttct cgcacaagag gagttggtgt gaatgagtat ggtcttccaa tggcagtggc     1500

acaagtatta tcgcagagcc tggctcaaaa ccttggaatc caatgggaac cttctagcag     1560

aaagccaaaa tgtgactgca cagaatcctg gggtggctgc atcatggagg aaacaggggt     1620

gtcccattct cgaaaatttt caaagtgcag cattttggag tatagagact ttttacagag     1680

aggaggtgga gcctgccttt tcaacaggcc aacaaagcta tttgagccca cggaatgtgg     1740

aaatggatac gtggaagctg gggaggagtg tgattgtggt tttcatgtgg aatgctatgg     1800

attatgctgt aagaaatgtt ccctctccaa cggggctcac tgcagcgacg ggccctgctg     1860

taacaatacc tcatgtcttt ttcagccacg agggtatgaa tgccgggatg ctgtgaacga     1920

gtgtgatatt actgaatatt gtactggaga ctctggtcag tgcccaccaa atcttcataa     1980

gcaagacgga tatgcatgca atcaaaatca gggccgctgc tacaatggcg agtgcaagac     2040

cagagacaac cagtgtcagt acatctgggg aacaaaggct gcagggtctg acaagttctg     2100

ctatgaaaag ctgaatacag aaggcactga gaagggaaac tgcgggaagg atggagaccg     2160

gtggattcag tgcagcaaac atgatgtgtt ctgtggattc ttactctgta ccaatcttac     2220

tcgagctcca cgtattggtc aacttcaggg tgagatcatt ccaacttcct tctaccatca     2280

aggccgggtg attgactgca gtggtgccca tgtagtttta gatgatgata cggatgtggg     2340

ctatgtagaa gatggaacgc catgtggccc gtctatgatg tgtttagatc ggaagtgcct     2400

acaaattcaa gccctaaata tgagcagctg tccactcgat tccaagggta aagtctgttc     2460

gggccatggg gtgtgtagta atgaagccac ctgcatttgt gatttcacct gggcagggac     2520

agattgcagt atccgggatc cagttaggaa ccttcacccc cccaaggatg aaggacccaa     2580

gggtcctagt gccaccaatc tcataatagg ctccatcgct ggtgccatcc tggtagcagc     2640

tattgtcctt gggggcacag gctggggatt taaaaatgtc aagaagagaa ggttcgatcc     2700

tactcagcaa ggccccatct gaatcagctg cgctggatgg acaccgcctt gcactgttgg     2760

attctgggta tgacatactc gcagcagtgt tactggaact attaagtttg taaacaaaac     2820

ctttgggtgg taatgactac ggagctaaag ttggggtgac aaggatgggg taaaagaaaa     2880

ctgtctcttt tggaaataat gtcaaagaac acctttcacc acctgtcagt aaacggggga     2940

gggggcaaaa gaccatgcta taaaaagaac tgttccagaa tctttttttt ccctaatgga     3000

cgaaggaaca acacacacac aaaaattaaa tgcaataaag gaatcattaa aaaaaaaaa      3059


<210>  286
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  286

Met Lys Pro Pro Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys 
1               5                   10                  15      


Ser Leu Ala Gly Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser 
            20                  25                  30          


Val Pro Ala Ser Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu 
        35                  40                  45              


Val Leu Leu Leu Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala 
    50                  55                  60                  


Trp Gly Ala Ala Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu 
65                  70                  75                  80  


Lys Asn Leu Gly Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn 
                85                  90                  95      


Ser Ser Ser Asn Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr 
            100                 105                 110         


Leu Pro Ser Arg Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro 
        115                 120                 125             


Tyr His Val Leu Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys 
    130                 135                 140                 


Ala Val His Leu Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser 
145                 150                 155                 160 


Lys Phe Ile Leu Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp 
                165                 170                 175     


Tyr Val Glu Ile His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly 
            180                 185                 190         


Gly Glu His Cys Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser 
        195                 200                 205             


Lys Val Ala Leu Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp 
    210                 215                 220                 


Asp Thr Phe Val Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu 
225                 230                 235                 240 


Lys Ser Thr Gly Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln 
                245                 250                 255     


Tyr Ser Lys Gln Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp 
            260                 265                 270         


Pro Phe Leu Ser Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val 
        275                 280                 285             


Asn Pro Ser Arg Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met 
    290                 295                 300                 


Ile Val Asn Asp His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala 
305                 310                 315                 320 


His Thr Asn Asn Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile 
                325                 330                 335     


Tyr Lys Glu Gln Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr 
            340                 345                 350         


Trp Thr Glu Lys Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met 
        355                 360                 365             


Leu His Glu Phe Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp 
    370                 375                 380                 


Ala Val His Leu Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser 
385                 390                 395                 400 


Leu Ser Tyr Phe Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val 
                405                 410                 415     


Asn Glu Tyr Gly Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser 
            420                 425                 430         


Leu Ala Gln Asn Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro 
        435                 440                 445             


Lys Cys Asp Cys Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr 
    450                 455                 460                 


Gly Val Ser His Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr 
465                 470                 475                 480 


Arg Asp Phe Leu Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro 
                485                 490                 495     


Thr Lys Leu Phe Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala 
            500                 505                 510         


Gly Glu Glu Cys Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys 
        515                 520                 525             


Cys Lys Lys Cys Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro 
    530                 535                 540                 


Cys Cys Asn Asn Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys 
545                 550                 555                 560 


Arg Asp Ala Val Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp 
                565                 570                 575     


Ser Gly Gln Cys Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys 
            580                 585                 590         


Asn Gln Asn Gln Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp 
        595                 600                 605             


Asn Gln Cys Gln Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys 
    610                 615                 620                 


Phe Cys Tyr Glu Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys 
625                 630                 635                 640 


Gly Lys Asp Gly Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe 
                645                 650                 655     


Cys Gly Phe Leu Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly 
            660                 665                 670         


Gln Leu Gln Gly Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg 
        675                 680                 685             


Val Ile Asp Cys Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp 
    690                 695                 700                 


Val Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys 
705                 710                 715                 720 


Leu Asp Arg Lys Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys 
                725                 730                 735     


Pro Leu Asp Ser Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser 
            740                 745                 750         


Asn Glu Ala Thr Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys 
        755                 760                 765             


Ser Ile Arg Asp Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly 
    770                 775                 780                 


Pro Lys Gly Pro Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly 
785                 790                 795                 800 


Ala Ile Leu Val Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe 
                805                 810                 815     


Lys Asn Val Lys Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile 
            820                 825                 830         


<210>  287
<211>  8475
<212>  DNA
<213>  Homo Sapiens

<400>  287
gttgtgacca ctgaacaaaa cttgcccatt gaaagcaaac ccggaacagc tggataatgt       60

ccaccccgag ccgattcaag aaggacaaag agatcatagc cgagtatgaa agtcaagtca      120

aagaaattcg agctcaactg gtagaacaac aaaaatgcct ggagcagcaa acggagatgc      180

gagttcagct tctccaggat ctgcaagatt tcttccgaaa aaaagctgaa attgagacgg      240

aatattcccg gaatctagag aagttagcag aaaggttcat ggcaaaaaca agaagcacta      300

aggatcatca acaatacaag aaagaccaga acctgttgtc tccagtgaac tgctggtatt      360

tgctcctgaa ccaagtaagg agagaaagca aagaccatgc aaccttgagt gacatctatc      420

tgaacaatgt gattatgcgg ttcatgcaga taagtgagga ttctaccagg atgtttaaaa      480

agagcaaaga gattgcattc caacttcatg aggatttaat gaaggttctt aatgagcttt      540

atacggtgat gaaaacatac catatgtatc atgcagagag catcagtgca gagagcaagc      600

tgaaagaggc cgaaaaacaa gaggaaaagc aaattgggag atctggtgat ccagtcttcc      660

atattcgact agaggagaga catcaacggc gaagctctgt aaagaaaatt gaaaaaatga      720

aagaaaaaag acaagcaaaa tattcagaaa ataagctaaa atcaattaag gcacggaacg      780

aatatctcct aacacttgaa gccaccaatg cctcagtttt caagtactat attcatgatc      840

tttctgattt aattgattgc tgtgatcttg gctaccatgc aagtctgaac agagccctaa      900

gaacatatct gtctgcggag tacaaccttg aaacctccag acatgagggc ttagacatta      960

ttgagaatgc agttgataat ttagagccca ggagcgataa gcagagattc atggagatgt     1020

accctgctgc gttctgtcca ccaatgaagt ttgagtttca gtctcacatg ggtgatgagg     1080

tgtgccaggt cagtgcccag cagccagtcc aggcagagct catgctcagg taccaacagt     1140

tgcagtcccg ccttgccacg ctcaaaatcg agaatgaaga ggttaagaaa acgactgaag     1200

ccaccttgca gacgatacaa gatatggtca ccatcgagga ctatgatgtt tctgaatgct     1260

tccagcacag tcgttccaca gaatcagtga agtccactgt ctctgaaacc tacctgagta     1320

aacccagcat cgccaagaga agagccaacc agcaggaaac tgaacagttc tacttcatga     1380

aactcagaga atatttggaa ggcagtaatc tcatcacaaa acttcaagcc aaacatgact     1440

tgctgcagag gaccctggga gaaggtcata gagctgaata tatgactaca aggcctccaa     1500

atgttccccc taagccccag aaacacagga agtccaggcc ccgctcacag tataatacta     1560

agttgtttaa tggggatttg gaaacattcg tcaaggactc aggacaggtt attcccctca     1620

ttgtggaaag ctgtattcgg ttcatcaatc tctatggtct tcagcatcag gggattttca     1680

gagtgtctgg ttcccaggtg gaagtcaatg atattaaaaa ttcatttgag agaggtgaaa     1740

atcctttggc tgatgaccag agtaaccatg atattaactc agttgctggc gttctgaagc     1800

tctatttccg tgggctggaa aaccccctct ttcctaagga aagatttaac gatctgattt     1860

cttgtatcag aatagataat ctctatgaga gggcgcttca catccgcaaa ctcctcctga     1920

ctttgcccag gtcggtcctt atagtgatga ggtacctctt tgccttcctc aatcatctat     1980

cacagtacag cgatgagaat atgatggacc cttataacct ggccatttgc tttggcccaa     2040

cattgatgcc tgtcccagaa atacaggatc aagtgtcttg ccaggcacat gtgaatgaaa     2100

ttatcaaaac catcatcatc caccatgaga ctattttccc agatgctaaa gagctggatg     2160

gccctgttta tgagaaatgt atggctggag atgactattg cgacagccca tacagtgagc     2220

acggtacatt ggaggaagtg gaccaagatg ctggtacaga gccccacaca agtgaagatg     2280

aatgtgagcc aatagaagca atagccaagt ttgactatgt tgggcggtct gccagagaac     2340

tatccttcaa gaagggtgcc tccctgctgc tgtatcaccg tgcatctgag gactggtggg     2400

aaggcaggca caacgggatt gacgggctgg tgcctcacca gtatatagtg gtgcaggata     2460

tggatgatac gttttcagac actctgagcc aaaaagccga cagtgaggcc agcagtgggc     2520

cagtcacgga agacaagtcc tcatccaagg acatgaactc cccgacagac cgtcatcctg     2580

acggctattt agccaggcaa cgaaaaagag gagagccacc ccctccagta aggcgtcctg     2640

gcaggaccag tgatggccat tgcccgctcc accctccaca tgccctttct aactcctcag     2700

ttgacctagg gtccccaagc cttgccagtc acccccgggg cctgctgcag aaccgtggcc     2760

tcaacaatga cagtcctgag cggaggcgca ggcctggcca tggcagcctg accaacatca     2820

gccggcacga ctccctcaag aagatcgaca gccctcccat tagaaggtcc acgtcatcag     2880

ggcaatacac gggcttcaat gaccacaagc cactggaccc agagacaatt gctcaggata     2940

ttgaagaaac gatgaacaca gctttgaatg aactccgaga actggagaga cagagcacag     3000

caaagcatgc ccctgatgtg gtgctggata ccctggagca agtgaaaaac tctcccaccc     3060

ctgccacttc cacggaatct ctcagccctt tgcacaacgt tgccctcagg agctccgagc     3120

ctcagattcg acgtagcacg agctcctcca gtgacacaat gagtactttc aagcctatgg     3180

tggcacccag aatgggcgtg cagctgaagc ctccagccct taggccaaaa cctgctgttc     3240

ttccaaaaac aaatcctacc ataggacctg ccccacctcc ccagggtcca acagacaagt     3300

catgcacaat gtaaaaacca gccaagcaag gccataaagg gaggtgactt aaaaaagaaa     3360

atggattagt gacaaaagtc actgatccat aactttcctt agttttgtgc ttataactgg     3420

agatcttttg gcttttctat gttgtcgaat gtaatgtctg agactagcta aattaacacg     3480

ggcatttgta ttttgtaatt tttttaaata actggacata tgtcatttta aggacaatag     3540

aaacacttag acttacttga aaatccaatg ctgcaccact tgtaatgaag gcaacaccgc     3600

tctccacatt gtacagagct tcaggtttaa tgtagcccag ctgagtcaga aaggttgtga     3660

cctgaaggca gaagaacccg aatgccacac ctcattggag tatagccagt gttggtctgt     3720

ggcacttggg ctgaaaggtg ataatggcat tgcgtggtag ctgacaatga gcaccttcgg     3780

ttccatgtgg agcggggttt agctcatgca aaagacttgc aattgtctcc atgggacgat     3840

cccagtggga ctgtcagccc acagctcgag tgggttggat gcttgcctct ttcctaacag     3900

ttatttcccc gggtccagct taaagactcg atggaaggag gtagaacctc tgctgttact     3960

gcttgaactt aacctgggaa aggagaggaa gacaccatct ccaaagctat taatgtcact     4020

ccttttgcga gcatgattag gccccggaga tttccaagtc cccccatcta cacttacaaa     4080

cgattagaag ggtttaattt taaagacttt ctggttacac tactccacga actcctccaa     4140

agatccgtta ttcaataact gcctagaaaa tgtttccatc tcctctaaat ccctgtgttc     4200

tcctctgtgg aaatgaaggc agcaagaagc acctgaggcc ttggttcatg cagtgttctc     4260

ttttgactaa atcacctagg ttcctttaaa catgctacaa agcccaggca tggtggtgca     4320

cacctgtact cccagctact cgggtggttt acacaggagg atggctttgg gcctagtagt     4380

tcgagtccag cctgggcagc atagtgtgag accctgtctc ttaaaaaaaa aaaaaatgct     4440

acaaagtcct gatgatccta aatttgaaat cccaactgtc ctctccattt gtctttgagc     4500

caaccctgaa ctggccctgg tacctgagta agagccatgc agggccatca gcagaacatg     4560

gccttgtggt tctcacccag ttgtgtacct cacaaccaca acttcttttt ctttgtccct     4620

tttccccttt ttggttttgg ttttgtatgt gggctctatg taactcccat agtcagctga     4680

actctcaatt ggagaccctc tttctctggc atcctagcac acaggcaatt ttttaagcct     4740

atatttatgc tacattttcc cccatcttaa gaaaatttgc tttgatttcc attctcctac     4800

tagcagcagc tgatatcacc tgtagaccta tgagcatttt atctattcta tcattgaagt     4860

tactgataaa gatttttgtt gttgttgttg ttgttgggag aaatggattt cccacaacta     4920

atccctctgg cccaccatta atttccttct tggtttcatt tcaaactggc agccaattgc     4980

acgcccatct aagagctaca cagtgtagat tttacttcat cagcccattg gtgaatgcat     5040

cgtgcagaaa agaactggga tctgtactaa aatcaagatc attactttga tctctacctc     5100

agtttgccag tgtagtcatt ctattgcagg aagagattaa attgatgaga tattgttact     5160

ttcagagtca cactgctgat tgcttgcctg gggcctaatt tcacaaatga atagtgactt     5220

ttttcccatg tatttctagg tatggtaaac ttttaaacct ccaaattttc agagccatac     5280

tttttgccca ttttgaaaaa gaagcccagg acagcacctt gtctagcccc tccccatttc     5340

tcctgagctt ttggggtcct tcagcaccct tggacaccgt ggagatccag ccaagactga     5400

gctttgaata gcactagccc ttttaaacaa tcctcacaaa ttccttagga atttaaactt     5460

tccaaaataa tcccccactt tttttttttt tttttttttt ttttgagttg gagtcttgct     5520

ctgtcgccca ggccagagta cagtggtgca atctcggctc cctgcaacct ccatctcccg     5580

ggttcaagca attctcctga gtagctggga ttacaggcgc caccaccacg cccagctaat     5640

ttttgtattt ttagtagaga tggggtgtca ccatgttggc caggctggtc tcaaactcct     5700

gacctcaggt gacccaccag cctcagcctc ccaaagtgct gggattacag atgtgagcca     5760

ccatgcccgg ccattccacc acttctttaa aatagtaaga attcttaaaa accatattcc     5820

ttgtttgatg gaagagtaag atgttaacag agggcatcaa agggccagag gtgtctttga     5880

atttattttt tttcaatgtc ttttctgagc ttcagcctta gcttttcaga tcttcctcct     5940

acctgttcat ttattcagcc ttctatctgg tcatcctccc cagcggctcc tctctctgat     6000

gtgtccacct acggtggaac gaggattgcc tttctgtgct ccccatcagg actttgctgt     6060

cttggccggc aggagtcgtg ctgctgcaga gcctcacagg ctgtgccttg tttcaggaaa     6120

cagctcctaa tactctccca tcactcactt tacctgtctc catcttattt ccctatactc     6180

ctattgtcag cttgagactt tttttttttt tcaattccaa atgaagggta tgacctcaga     6240

gtgagtgagg actcagtaaa gactcacctc tccttacttg gtttattaaa tgtcttcaga     6300

ttccagagat aagacaaggt ggccacttca caaagaatcc agaatcatgc tcagtaaagc     6360

tcattaaaag ccactgcagc tgagaaggtt cacagccctt ctttatagcc acagaggcag     6420

cacacagggg aggtgggaag acacagggaa acgagagaag aaggataatg aggccttgag     6480

gtgttctgcc cccaatttca aggagcttat caggcttcat gtgcaatttg gggaggggag     6540

ctttttgatg gtgggtaaat aatggctcta caaagattac ctgactccac tgacacaaga     6600

atatgtattc tcagctgata taactgtgtg ttcacatccc atccatagaa ctcactgaag     6660

gagattcatc aagtcagcct tttggactgg gttggggttt ggggagtgga tttggggata     6720

gagagaaagg tgtacttagt acacattttc taatgggcgt tacgtgaact gtttgaacct     6780

gctgagtggc gctttgtaga gctccatgtt cacgttcagt gtcaacacca ttcaacagct     6840

ttgcacatct tcgtacaaca taatctggct ttggtgcccc ttgagccacc tgtagaataa     6900

tttatagcag ggtcccacaa tctactgcaa tgatcgtgaa cagttatcag tggatatagt     6960

gctccaagag tcaaattgta tccgttaagg gttttctaac ttttgctatc ccccccgcga     7020

ccaaaaaaag ggggggttta taatttaaag aaaaggaaaa gaggcgtggg ttggtagttg     7080

tgtccttaac atttaggaat gacatagcct ctggagtcta caaactgaag aaactttcat     7140

ctgatcagcc ttggaaatcc aaagttaaag agcctatgtg tctcttgagg cgggggttag     7200

aggattcaaa tttgggatga tgctcattga ttcctgacca tagcagtgag aggccatttt     7260

ttgtgcagga aatgtgctta ggactcagtc ttgttttcga ttatccacca cagaaaccct     7320

gagacacaga gcagcttaga agtctctacc caggcgtaaa tagagctccc tactccagac     7380

cacctgccac ccacctccca agttgagaac acaagctcca gctgggctgg agagtcaggc     7440

ttggtgcagg gtgactttgg cgaagttttg tcagatccat aaagcaaact ggaatttgag     7500

ctttcactta ccctagtata cgttcttaaa aaaaaaaaaa agtctatgtg gtataatcga     7560

gatggatacc tgtgtcttta aattacgtag ggaattttgt atgtttaaat aattgtactg     7620

ggttccataa tgcttatctt agaaacttta gtaaaagaaa atatatgaac cgtgcatttg     7680

tgaatgcccc ccttagagca ttcatccaag ttcagtgtgt agtgtgatgg ttattataga     7740

tatttaaagt atagtaagtg gctgtgtaac aggagagact gctgtttacc tacgtactga     7800

agggtaactg ctgcccgcgt aattaaatca gtattgtcct ttcctgtcgg tttgatcaat     7860

tgcggtaccg gtagcttcct gcttgtgact gttacctaat tgtgtcaatg tacatctgta     7920

gtatgtacat gtgaaagtgc ctttctattt tagaggagtt ttagccttgc tcttgtaccg     7980

ttgccccgct ctgtgcccca cccccacctc ctcctcccaa ttcctgctgc ccactcgagt     8040

gtttcgaagc ttcctccctg tcccccacct tccccatccc cgccttcctg tgcctcggtg     8100

ctcagtaatg tcccatctca cctccctgtc ggtcctcaga ctgtctcgtt ttccttgtag     8160

acgtgattgt gcctttctca cccctgtgtc ctcccatccc accgcatcag tcccccgctc     8220

atgtgctgct gacagcatcg cattcgcccg tgctctgtac tgcctctcac catttcattc     8280

cctcctctct gaggtgaaaa taaaggggga tgcttttaca gtctggaaag aaaaaaaatg     8340

ttttgttaat ctgttgtgac aatgcacttt tatgtatagt actgtacatt tttggcatgt     8400

accattacag gcttcagtat acagtcaggt ttgttcttca cggtgtatct ttataataaa     8460

taagatagtt ctggc                                                      8475


<210>  288
<211>  1085
<212>  PRT
<213>  Homo Sapiens

<400>  288

Met Ser Thr Pro Ser Arg Phe Lys Lys Asp Lys Glu Ile Ile Ala Glu 
1               5                   10                  15      


Tyr Glu Ser Gln Val Lys Glu Ile Arg Ala Gln Leu Val Glu Gln Gln 
            20                  25                  30          


Lys Cys Leu Glu Gln Gln Thr Glu Met Arg Val Gln Leu Leu Gln Asp 
        35                  40                  45              


Leu Gln Asp Phe Phe Arg Lys Lys Ala Glu Ile Glu Thr Glu Tyr Ser 
    50                  55                  60                  


Arg Asn Leu Glu Lys Leu Ala Glu Arg Phe Met Ala Lys Thr Arg Ser 
65                  70                  75                  80  


Thr Lys Asp His Gln Gln Tyr Lys Lys Asp Gln Asn Leu Leu Ser Pro 
                85                  90                  95      


Val Asn Cys Trp Tyr Leu Leu Leu Asn Gln Val Arg Arg Glu Ser Lys 
            100                 105                 110         


Asp His Ala Thr Leu Ser Asp Ile Tyr Leu Asn Asn Val Ile Met Arg 
        115                 120                 125             


Phe Met Gln Ile Ser Glu Asp Ser Thr Arg Met Phe Lys Lys Ser Lys 
    130                 135                 140                 


Glu Ile Ala Phe Gln Leu His Glu Asp Leu Met Lys Val Leu Asn Glu 
145                 150                 155                 160 


Leu Tyr Thr Val Met Lys Thr Tyr His Met Tyr His Ala Glu Ser Ile 
                165                 170                 175     


Ser Ala Glu Ser Lys Leu Lys Glu Ala Glu Lys Gln Glu Glu Lys Gln 
            180                 185                 190         


Ile Gly Arg Ser Gly Asp Pro Val Phe His Ile Arg Leu Glu Glu Arg 
        195                 200                 205             


His Gln Arg Arg Ser Ser Val Lys Lys Ile Glu Lys Met Lys Glu Lys 
    210                 215                 220                 


Arg Gln Ala Lys Tyr Ser Glu Asn Lys Leu Lys Ser Ile Lys Ala Arg 
225                 230                 235                 240 


Asn Glu Tyr Leu Leu Thr Leu Glu Ala Thr Asn Ala Ser Val Phe Lys 
                245                 250                 255     


Tyr Tyr Ile His Asp Leu Ser Asp Leu Ile Asp Cys Cys Asp Leu Gly 
            260                 265                 270         


Tyr His Ala Ser Leu Asn Arg Ala Leu Arg Thr Tyr Leu Ser Ala Glu 
        275                 280                 285             


Tyr Asn Leu Glu Thr Ser Arg His Glu Gly Leu Asp Ile Ile Glu Asn 
    290                 295                 300                 


Ala Val Asp Asn Leu Glu Pro Arg Ser Asp Lys Gln Arg Phe Met Glu 
305                 310                 315                 320 


Met Tyr Pro Ala Ala Phe Cys Pro Pro Met Lys Phe Glu Phe Gln Ser 
                325                 330                 335     


His Met Gly Asp Glu Val Cys Gln Val Ser Ala Gln Gln Pro Val Gln 
            340                 345                 350         


Ala Glu Leu Met Leu Arg Tyr Gln Gln Leu Gln Ser Arg Leu Ala Thr 
        355                 360                 365             


Leu Lys Ile Glu Asn Glu Glu Val Lys Lys Thr Thr Glu Ala Thr Leu 
    370                 375                 380                 


Gln Thr Ile Gln Asp Met Val Thr Ile Glu Asp Tyr Asp Val Ser Glu 
385                 390                 395                 400 


Cys Phe Gln His Ser Arg Ser Thr Glu Ser Val Lys Ser Thr Val Ser 
                405                 410                 415     


Glu Thr Tyr Leu Ser Lys Pro Ser Ile Ala Lys Arg Arg Ala Asn Gln 
            420                 425                 430         


Gln Glu Thr Glu Gln Phe Tyr Phe Met Lys Leu Arg Glu Tyr Leu Glu 
        435                 440                 445             


Gly Ser Asn Leu Ile Thr Lys Leu Gln Ala Lys His Asp Leu Leu Gln 
    450                 455                 460                 


Arg Thr Leu Gly Glu Gly His Arg Ala Glu Tyr Met Thr Thr Arg Pro 
465                 470                 475                 480 


Pro Asn Val Pro Pro Lys Pro Gln Lys His Arg Lys Ser Arg Pro Arg 
                485                 490                 495     


Ser Gln Tyr Asn Thr Lys Leu Phe Asn Gly Asp Leu Glu Thr Phe Val 
            500                 505                 510         


Lys Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser Cys Ile Arg 
        515                 520                 525             


Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe Arg Val Ser 
    530                 535                 540                 


Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe Glu Arg Gly 
545                 550                 555                 560 


Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile Asn Ser Val 
                565                 570                 575     


Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn Pro Leu Phe 
            580                 585                 590         


Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg Ile Asp Asn 
        595                 600                 605             


Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu Thr Leu Pro 
    610                 615                 620                 


Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe Leu Asn His 
625                 630                 635                 640 


Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr Asn Leu Ala 
                645                 650                 655     


Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile Gln Asp Gln 
            660                 665                 670         


Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr Ile Ile Ile 
        675                 680                 685             


His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp Gly Pro Val 
    690                 695                 700                 


Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser Pro Tyr Ser 
705                 710                 715                 720 


Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly Thr Glu Pro 
                725                 730                 735     


His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile Ala Lys Phe 
            740                 745                 750         


Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys Lys Gly Ala 
        755                 760                 765             


Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp Glu Gly Arg 
    770                 775                 780                 


His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile Val Val Gln 
785                 790                 795                 800 


Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys Ala Asp Ser 
                805                 810                 815     


Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser Ser Lys Asp 
            820                 825                 830         


Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu Ala Arg Gln 
        835                 840                 845             


Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro Gly Arg Thr 
    850                 855                 860                 


Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu Ser Asn Ser 
865                 870                 875                 880 


Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro Arg Gly Leu 
                885                 890                 895     


Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg Arg Arg Arg 
            900                 905                 910         


Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp Ser Leu Lys 
        915                 920                 925             


Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser Gly Gln Tyr 
    930                 935                 940                 


Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr Ile Ala Gln 
945                 950                 955                 960 


Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu Arg Glu Leu 
                965                 970                 975     


Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val Leu Asp Thr 
            980                 985                 990         


Leu Glu Gln Val Lys Asn Ser Pro  Thr Pro Ala Thr Ser  Thr Glu Ser 
        995                 1000                 1005             


Leu Ser  Pro Leu His Asn Val  Ala Leu Arg Ser Ser  Glu Pro Gln 
    1010                 1015                 1020             


Ile Arg  Arg Ser Thr Ser Ser  Ser Ser Asp Thr Met  Ser Thr Phe 
    1025                 1030                 1035             


Lys Pro  Met Val Ala Pro Arg  Met Gly Val Gln Leu  Lys Pro Pro 
    1040                 1045                 1050             


Ala Leu  Arg Pro Lys Pro Ala  Val Leu Pro Lys Thr  Asn Pro Thr 
    1055                 1060                 1065             


Ile Gly  Pro Ala Pro Pro Pro  Gln Gly Pro Thr Asp  Lys Ser Cys 
    1070                 1075                 1080             


Thr Met  
    1085 


<210>  289
<211>  1591
<212>  DNA
<213>  Homo Sapiens

<400>  289
atataagcgt tggcggagcg tcggttgtag cactctgcgc gcccgctctt ctgctgctgt       60

ttgtctactt cctcctgctt ccccgccgcc gccgccgcca tcatgaggga aatcgtgcac      120

ttgcaggccg ggcagtgcgg caaccaaatc ggcgccaagt tttgggaggt gatcagcgat      180

gagcacggca tcgaccccac gggcacctac cacggggaca gcgacctgca gctggaacgc      240

atcaacgtgt actacaatga ggccaccggc ggcaagtacg tgccccgcgc cgtgctcgtg      300

gatctggagc ccggcaccat ggactccgtg cgctcggggc ccttcgggca gatcttccgg      360

ccggacaact tcgttttcgg tcagagtggt gctgggaaca actgggccaa ggggcactac      420

acagaaggcg cggagctggt ggactcggtg ctggatgttg tgagaaagga ggctgagagc      480

tgtgactgcc tgcagggttt ccagctgacc cactccctgg gtggggggac tgggtctggg      540

atgggtaccc tcctcatcag caagatccgg gaggagtacc cagacaggat catgaacacg      600

tttagtgtgg tgccttcgcc caaagtgtca gacacagtgg tggagcccta caacgccacc      660

ctctcagtcc accagctcgt agaaaacaca gacgagacct actgcattga taacgaagct      720

ctctacgaca tttgcttcag aaccctaaag ctgaccacgc ccacctatgg tgacctgaac      780

cacctggtgt ctgctaccat gagtggggtc accacctgcc tgcgcttccc aggccagctc      840

aatgctgacc tgcggaagct ggctgtgaac atggtcccgt ttccccggct gcacttcttc      900

atgcccggct ttgccccact gaccagccgg ggcagccagc agtaccgggc gctgaccgtg      960

cccgagctca cccagcagat gtttgatgcc aagaacatga tggctgcctg cgacccccgc     1020

catggccgct acctgacggt tgccgccgtg ttcaggggcc gcatgtccat gaaggaggtg     1080

gatgagcaaa tgcttaatgt ccaaaacaaa aacagcagct attttgttga gtggatcccc     1140

aacaatgtga aaacggctgt ctgtgacatc ccacctcggg ggctaaaaat gtccgccacc     1200

ttcattggca acagcacggc catccaggag ctgttcaagc gcatctccga gcagttcacg     1260

gccatgttcc ggcgcaaggc cttcctgcac tggtacacgg gcgagggcat ggacgagatg     1320

gagttcaccg aggccgagag caacatgaat gacctggtgt ccgagtacca gcagtaccag     1380

gatgccacag ccgaggagga gggcgagttc gaggaggagg ctgaggagga ggtggcctag     1440

agccttcagt cactggggaa agcagggaag cagtgtgaac tctttattca ctcccagcct     1500

gtcctgtggc ctgtcccact gtgtgcactt gctgttttcc ctgtccacat ccatgctgta     1560

cagacaccac cattaaagca ttttcatagt g                                    1591


<210>  290
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  290

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 445 


<210>  291
<211>  2027
<212>  DNA
<213>  Homo Sapiens

<400>  291
agcgcagggc ggtaactctg ggcggggctg ggctccaggg ctggacagca cagtccctct       60

gaactgcaca gagacctcgc aggccccgag aactgtcgcc cttccacgat gtggctccgt      120

gcctttatcc tggccactct ctctgcttcc gcggcttggg cagggcatcc gtcctcgcca      180

cctgtggtgg acaccgtgca tggcaaagtg ctggggaagt tcgtcagctt agaaggattt      240

gcacagcctg tggccatttt cctgggaatc ccttttgcca agccgcctct tggacccctg      300

aggtttactc caccgcagcc tgcagaacca tggagctttg tgaagaatgc cacctcgtac      360

cctcctatgt gcacccaaga tcccaaggcg gggcagttac tctcagagct atttacaaac      420

cgaaaggaga acattcctct caagctttct gaagactgtc tttacctcaa tatttacact      480

cctgctgact tgaccaagaa aaacaggctg ccggtgatgg tgtggatcca cggagggggg      540

ctgatggtgg gtgcggcatc aacctatgat gggctggccc ttgctgccca tgaaaacgtg      600

gtggtggtga ccattcaata tcgcctgggc atctggggat tcttcagcac aggggatgaa      660

cacagccggg ggaactgggg tcacctggac caggtggctg ccctgcgctg ggtccaggac      720

aacattgcca gctttggagg gaacccaggc tctgtgacca tctttggaga gtcagcggga      780

ggagaaagtg tctctgttct tgttttgtct ccattggcca agaacctctt ccaccgggcc      840

atttctgaga gtggcgtggc cctcacttct gttctggtga agaaaggtga tgtcaagccc      900

ttggctgagc aaattgctat cactgctggg tgcaaaacca ccacctctgc tgtcatggtt      960

cactgcctgc gacagaagac ggaagaggag ctcttggaga cgacattgaa aatgaaattc     1020

ttatctctgg acttacaggg agaccccaga gagagtcaac cccttctggg cactgtgatt     1080

gatgggatgc tgctgctgaa aacacctgaa gagcttcaag ctgaaaggaa tttccacact     1140

gtcccctaca tggtcggaat taacaagcag gagtttggct ggttgattcc aatgcagttg     1200

atgagctatc cactctccga agggcaactg gaccagaaga cagccatgtc actcctgtgg     1260

aagtcctatc cccttgtttg cattgctaag gaactgattc cagaagccac tgagaaatac     1320

ttaggaggaa cagacgacac tgtcaaaaag aaagacctgt tcctggactt gatagcagat     1380

gtgatgtttg gtgtcccatc tgtgattgtg gcccggaacc acagagatgc tggagcaccc     1440

acctacatgt atgagtttca gtaccgtcca agcttctcat cagacatgaa acccaagacg     1500

gtgataggag accacgggga tgagctcttc tccgtctttg gggccccatt tttaaaagag     1560

ggtgcctcag aagaggagat cagacttagc aagatggtga tgaaattctg ggccaacttt     1620

gctcgcaatg gaaaccccaa tggggaaggg ctgccccact ggccagagta caaccagaag     1680

gaagggtatc tgcagattgg tgccaacacc caggcggccc agaagctgaa ggacaaagaa     1740

gtagctttct ggaccaacct ctttgccaag aaggcagtgg agaagccacc ccagacagaa     1800

cacatagagc tgtgaatgaa gatccagccg gccttgggag cctggaggag caaagactgg     1860

ggtcttttgc gaaagggatt gcaggttcag aaggcatctt accatggctg gggaattgtc     1920

tggtggtggg gggcagggga cagaggccat gaaggagcaa gttttgtatt tgtgacctca     1980

gctttgggaa taaaggatct tttgaaggcc aaaaaaaaaa aaaaaaa                   2027


<210>  292
<211>  568
<212>  PRT
<213>  Homo Sapiens

<400>  292

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Ala Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly 
            20                  25                  30          


Lys Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val 
        35                  40                  45              


Ala Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu 
    50                  55                  60                  


Arg Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn 
65                  70                  75                  80  


Ala Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln 
                85                  90                  95      


Leu Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys 
            100                 105                 110         


Leu Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu 
        115                 120                 125             


Thr Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly 
    130                 135                 140                 


Leu Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala 
145                 150                 155                 160 


His Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp 
                165                 170                 175     


Gly Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His 
            180                 185                 190         


Leu Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser 
        195                 200                 205             


Phe Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly 
    210                 215                 220                 


Gly Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu 
225                 230                 235                 240 


Phe His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu 
                245                 250                 255     


Val Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr 
            260                 265                 270         


Ala Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg 
        275                 280                 285             


Gln Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe 
    290                 295                 300                 


Leu Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu 
305                 310                 315                 320 


Gly Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu 
                325                 330                 335     


Gln Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn 
            340                 345                 350         


Lys Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro 
        355                 360                 365             


Leu Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp 
    370                 375                 380                 


Lys Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala 
385                 390                 395                 400 


Thr Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp 
                405                 410                 415     


Leu Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val 
            420                 425                 430         


Ile Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr 
        435                 440                 445             


Glu Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr 
    450                 455                 460                 


Val Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro 
465                 470                 475                 480 


Phe Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met 
                485                 490                 495     


Val Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly 
            500                 505                 510         


Glu Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu 
        515                 520                 525             


Gln Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu 
    530                 535                 540                 


Val Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro 
545                 550                 555                 560 


Pro Gln Thr Glu His Ile Glu Leu 
                565             


<210>  293
<211>  3913
<212>  DNA
<213>  Homo Sapiens

<400>  293
ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg       60

tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag      120

gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg      180

ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc      240

gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc      300

tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc      360

cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat      420

gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg      480

caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc      540

acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt      600

gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat      660

gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat      720

agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa      780

aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt      840

acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt      900

attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac      960

atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag     1020

tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat     1080

gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata     1140

atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct     1200

ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc     1260

ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg     1320

gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca     1380

gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg     1440

ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg     1500

cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc     1560

agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg     1620

gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag     1680

atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac     1740

tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat     1800

tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa     1860

atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg     1920

tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc     1980

ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc     2040

ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa     2100

ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat     2160

tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa     2220

aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt     2280

atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca     2340

atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt     2400

tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg     2460

tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg     2520

gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc     2580

ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa     2640

aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt     2700

cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg     2760

tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc     2820

cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc     2880

catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga     2940

tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca     3000

aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac     3060

agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg     3120

aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt     3180

aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat     3240

gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc     3300

agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc     3360

cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa     3420

cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa     3480

aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat     3540

ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt     3600

aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat     3660

cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc     3720

ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact     3780

tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca     3840

ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa     3900

aaaaaaaaaa aaa                                                        3913


<210>  294
<211>  766
<212>  PRT
<213>  Homo Sapiens

<400>  294

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  295
<211>  1601
<212>  DNA
<213>  Homo Sapiens

<400>  295
ggcgaccgcg gctgaggtac aggtgcctcg cggtgcagcc gggtcgcctt ccagcccgtc       60

cgcctcccga ccagggcccg cgccccgtcc cgcctctctc ccgcccagcc aaatgcaggc      120

cgccgccctc cctgaggaga tccgttggct cctggaagat gctgaagagt ttctggcaga      180

aggtttgcgg aatgagaacc tcagcgctgt tgcaagggat cacagagacc atattctacg      240

gggctttcag caaatcaaag ccaggtacta ttgggatttt cagccccaag ggggagacat      300

tggacaggac agctctgatg ataatcacag cgggactctt ggcctgtccc tcacatccga      360

tgcacccttt ttgtcagatt atcaggatga gggaatggaa gacatcgtaa aaggagctca      420

agaacttgat aacgtaatca agcaaggata cttggagaag aaaagcaaag atcatagttt      480

ctttggatcg gagtggcaga agcgatggtg tgttgtcagc agaggtctct tctactacta      540

tgctaatgag aagagcaagc agcccaaagg gaccttcctc attaagggct acggtgtacg      600

gatggccccc cacctgcgaa gagattccaa gaaagaatcc tgctttgaac tgacctccca      660

ggataggcgc agctatgagt ttacagctac tagtccagca gaagccagag actgggtgga      720

tcaaataagt ttcttgttaa aggatctgag ctccttaacc attccatatg aagaggatga      780

ggaggaagaa gaaaaagaag agacatatga tgatattgat ggttttgact ccccaagttg      840

tggttcccag tgcagaccca ctatcttgcc tgggagtgtg gggataaaag agcctacaga      900

ggagaaagaa gaagaagata tttatgaagt cttgccagat gaagagcatg atctagaaga      960

ggatgagagt ggcactcgac gaaaaggagt agactatgcc agttactacc agggcctatg     1020

ggattgccat ggtgaccagc cagatgaact gtccttccaa cggggtgacc tcatccgtat     1080

tctgagcaag gagtataaca tgtatggctg gtgggtggga gaactgaaca gcctcgttgg     1140

gattgttcca aaggagtatc tcaccactgc ctttgaagtg gaagaaagat gaaacccagg     1200

aaatatattc ttccctctct cctgccttta tgaggaaact gatcatcaaa agttcccact     1260

ccctacttct gccaccccac caacgccttg gactcctctc tttgctgaag agacccaagt     1320

ctcttgacac ctcagagtga ctgtaagcta ccagtaagac aagtgggaag aggcacgttc     1380

atcaaacctg ttactaaacc agcctagtca tagctcatcc ccatctctaa atgtgtccac     1440

acaaccacat ctgccttttc cacaagcttt tcacaaagaa ggtgagagag aaggaaacct     1500

tgggaggagg acattactgg ttgttctggc tggtttgaaa agcacaaata aacttgggat     1560

gtggttcctt gccatgaaaa aaaaaaaaaa aaaaaaaaaa a                         1601


<210>  296
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  296

Met Gln Ala Ala Ala Leu Pro Glu Glu Ile Arg Trp Leu Leu Glu Asp 
1               5                   10                  15      


Ala Glu Glu Phe Leu Ala Glu Gly Leu Arg Asn Glu Asn Leu Ser Ala 
            20                  25                  30          


Val Ala Arg Asp His Arg Asp His Ile Leu Arg Gly Phe Gln Gln Ile 
        35                  40                  45              


Lys Ala Arg Tyr Tyr Trp Asp Phe Gln Pro Gln Gly Gly Asp Ile Gly 
    50                  55                  60                  


Gln Asp Ser Ser Asp Asp Asn His Ser Gly Thr Leu Gly Leu Ser Leu 
65                  70                  75                  80  


Thr Ser Asp Ala Pro Phe Leu Ser Asp Tyr Gln Asp Glu Gly Met Glu 
                85                  90                  95      


Asp Ile Val Lys Gly Ala Gln Glu Leu Asp Asn Val Ile Lys Gln Gly 
            100                 105                 110         


Tyr Leu Glu Lys Lys Ser Lys Asp His Ser Phe Phe Gly Ser Glu Trp 
        115                 120                 125             


Gln Lys Arg Trp Cys Val Val Ser Arg Gly Leu Phe Tyr Tyr Tyr Ala 
    130                 135                 140                 


Asn Glu Lys Ser Lys Gln Pro Lys Gly Thr Phe Leu Ile Lys Gly Tyr 
145                 150                 155                 160 


Gly Val Arg Met Ala Pro His Leu Arg Arg Asp Ser Lys Lys Glu Ser 
                165                 170                 175     


Cys Phe Glu Leu Thr Ser Gln Asp Arg Arg Ser Tyr Glu Phe Thr Ala 
            180                 185                 190         


Thr Ser Pro Ala Glu Ala Arg Asp Trp Val Asp Gln Ile Ser Phe Leu 
        195                 200                 205             


Leu Lys Asp Leu Ser Ser Leu Thr Ile Pro Tyr Glu Glu Asp Glu Glu 
    210                 215                 220                 


Glu Glu Glu Lys Glu Glu Thr Tyr Asp Asp Ile Asp Gly Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Cys Gly Ser Gln Cys Arg Pro Thr Ile Leu Pro Gly Ser Val 
                245                 250                 255     


Gly Ile Lys Glu Pro Thr Glu Glu Lys Glu Glu Glu Asp Ile Tyr Glu 
            260                 265                 270         


Val Leu Pro Asp Glu Glu His Asp Leu Glu Glu Asp Glu Ser Gly Thr 
        275                 280                 285             


Arg Arg Lys Gly Val Asp Tyr Ala Ser Tyr Tyr Gln Gly Leu Trp Asp 
    290                 295                 300                 


Cys His Gly Asp Gln Pro Asp Glu Leu Ser Phe Gln Arg Gly Asp Leu 
305                 310                 315                 320 


Ile Arg Ile Leu Ser Lys Glu Tyr Asn Met Tyr Gly Trp Trp Val Gly 
                325                 330                 335     


Glu Leu Asn Ser Leu Val Gly Ile Val Pro Lys Glu Tyr Leu Thr Thr 
            340                 345                 350         


Ala Phe Glu Val Glu Glu Arg 
        355                 


<210>  297
<211>  2164
<212>  DNA
<213>  Homo Sapiens

<400>  297
ataaatatca gagtgtgctg ctgtggcttt gtggagctgc cagagtaaag caaagagaaa       60

ggaagcaggc ccgttggaag tggttgtgac aaccccagca atgtggagaa gcctggggct      120

tgccctggct ctctgtctcc tcccatcggg aggaacagag agccaggacc aaagctcctt      180

atgtaagcaa cccccagcct ggagcataag agatcaagat ccaatgctaa actccaatgg      240

ttcagtgact gtggttgctc ttcttcaagc cagctgatac ctgtgcatac tgcaggcatc      300

taaattagaa gacctgcgag taaaactgaa gaaagaagga tattctaata tttcttatat      360

tgttgttaat catcaaggaa tctcttctcg attaaaatac acacatctta agaataaggt      420

ttcagagcat attcctgttt atcaacaaga agaaaaccaa acagatgtct ggactctttt      480

aaatggaagc aaagatgact tcctcatata tgatagatgt ggccgtcttg tatatcatct      540

tggtttgcct ttttccttcc taactttccc atatgtagaa gaagccatta agattgctta      600

ctgtgaaaag aaatgtggaa actgctctct cacgactctc aaagatgaag acttttgtaa      660

acgtgtatct ttggctactg tggataaaac agttgaaact ccatcgcctc attaccatca      720

tgagcatcat cacaatcatg gacatcagca ccttggcagc agtgagcttt cagagaatca      780

gcaaccagga gcaccaaatg ctcctactca tcctgctcct ccaggccttc atcaccacca      840

taagcacaag ggtcagcata ggcagggtca cccagagaac cgagatatgc cagcaagtga      900

agatttacaa gatttacaaa agaagctctg tcgaaagaga tgtataaatc aattactctg      960

taaattgccc acagattcag agttggctcc taggagctga tgctgccatt gtcgacatct     1020

gatatttgaa aaaacagggt ctgcaatcac ctgacagtgt aaagaaaacc tcccatcttt     1080

atgtagctga cagggacttc gggcagagga gaacataact gaatcttgtc agtgacgttt     1140

gcctccagct gcctgacaaa taagtcagca gcttataccc acagaagcca gtgccagttg     1200

acgctgaaag aatcaggcaa aaaagtgaga atgaccttca aactaaatat ttaaaatagg     1260

acatactccc caatttagtc tagacacaat ttcatttcca gcatttttat aaactaccaa     1320

attagtgaac caaaaataga aattagattt gtgcaaacat ggagaaatct actgaattgg     1380

cttccagatt ttaaatttta tgtcatagaa atattgactc aaaccatatt ttttatgatg     1440

gagcaactga aaggtgattg cagcttttgg ttaatatgtc tttttttttc tttttccagt     1500

gttctatttg ctttaatgag aatagaaacg taaactatga cctaggggtt tctgttggat     1560

aattagcagt ttagaatgga ggaagaacaa caaagacatg ctttccattt ttttctttac     1620

ttatctctca aaacaatatt actttgtctt ttcaatcttc tacttttaac taataaaata     1680

agtggatttt gtattttaag atccagaaat acttaacacg tgaatatttt gctaaaaaag     1740

catatataac tattttaaat atccatttat cttttgtata tctaagactc atcctgattt     1800

ttactatcac acatgaataa agcctttgta tctttctttc tctaatgttg tatcatactc     1860

ttctaaaact tgagtggctg tcttaaaaga tataagggga aagataatat tgtctgtctc     1920

tatattgctt agtaagtatt tccatagtca atgatggttt aataggtaaa ccaaacccta     1980

taaacctgac ctcctttatg gttaatacta ttaagcaaga atgcagtaca gaattggata     2040

cagtacggat ttgtccaaat aaattcaata aaaaccttaa agctgaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaa                                                                  2164


<210>  298
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  298

Met Trp Arg Ser Leu Gly Leu Ala Leu Ala Leu Cys Leu Leu Pro Ser 
1               5                   10                  15      


Gly Gly Thr Glu Ser Gln Asp Gln Ser Ser Leu Cys Lys Gln Pro Pro 
            20                  25                  30          


Ala Trp Ser Ile Arg Asp Gln Asp Pro Met Leu Asn Ser Asn Gly Ser 
        35                  40                  45              


Val Thr Val Val Ala Leu Leu Gln Ala Ser Tyr Leu Cys Ile Leu Gln 
    50                  55                  60                  


Ala Ser Lys Leu Glu Asp Leu Arg Val Lys Leu Lys Lys Glu Gly Tyr 
65                  70                  75                  80  


Ser Asn Ile Ser Tyr Ile Val Val Asn His Gln Gly Ile Ser Ser Arg 
                85                  90                  95      


Leu Lys Tyr Thr His Leu Lys Asn Lys Val Ser Glu His Ile Pro Val 
            100                 105                 110         


Tyr Gln Gln Glu Glu Asn Gln Thr Asp Val Trp Thr Leu Leu Asn Gly 
        115                 120                 125             


Ser Lys Asp Asp Phe Leu Ile Tyr Asp Arg Cys Gly Arg Leu Val Tyr 
    130                 135                 140                 


His Leu Gly Leu Pro Phe Ser Phe Leu Thr Phe Pro Tyr Val Glu Glu 
145                 150                 155                 160 


Ala Ile Lys Ile Ala Tyr Cys Glu Lys Lys Cys Gly Asn Cys Ser Leu 
                165                 170                 175     


Thr Thr Leu Lys Asp Glu Asp Phe Cys Lys Arg Val Ser Leu Ala Thr 
            180                 185                 190         


Val Asp Lys Thr Val Glu Thr Pro Ser Pro His Tyr His His Glu His 
        195                 200                 205             


His His Asn His Gly His Gln His Leu Gly Ser Ser Glu Leu Ser Glu 
    210                 215                 220                 


Asn Gln Gln Pro Gly Ala Pro Asn Ala Pro Thr His Pro Ala Pro Pro 
225                 230                 235                 240 


Gly Leu His His His His Lys His Lys Gly Gln His Arg Gln Gly His 
                245                 250                 255     


Pro Glu Asn Arg Asp Met Pro Ala Ser Glu Asp Leu Gln Asp Leu Gln 
            260                 265                 270         


Lys Lys Leu Cys Arg Lys Arg Cys Ile Asn Gln Leu Leu Cys Lys Leu 
        275                 280                 285             


Pro Thr Asp Ser Glu Leu Ala Pro Arg Ser Cys Cys His Cys Arg His 
    290                 295                 300                 


Leu Ile Phe Glu Lys Thr Gly Ser Ala Ile Thr Gln Cys Lys Glu Asn 
305                 310                 315                 320 


Leu Pro Ser Leu Cys Ser Gln Gly Leu Arg Ala Glu Glu Asn Ile Thr 
                325                 330                 335     


Glu Ser Cys Gln Arg Leu Pro Pro Ala Ala Gln Ile Ser Gln Gln Leu 
            340                 345                 350         


Ile Pro Thr Glu Ala Ser Ala Ser Arg Lys Asn Gln Ala Lys Lys Glu 
        355                 360                 365             


Pro Ser Asn 
    370     


<210>  299
<211>  4400
<212>  DNA
<213>  Homo Sapiens

<400>  299
acgcggggct cgggtggccg cggcagcagc agcagcaacc cccgccgctc gcggtcggcc       60

cccgggccgc agccatggtc ccgagtggcg gcgtccccca gggcctcggc ggccgctctg      120

cctgcgcgct gctcctgctc tgctacctga atgttgtacc atctttgggt aggcagactt      180

tccctgacga catcagtgat acccaaagct gagcagagcg tggcttacaa agactttatt      240

tattttactg tctttgaagg aaacgttcgc aacgtttctg aagtctcggt tgagtattta      300

tgctctcagc cttgtgttgt caatttggaa gcagttgttt catctgagtt cagaagtagc      360

attcccgtgt acaaaaaaag gtggaagaat gagaaacatc ttcacaccag caggacacaa      420

atagtacatg tgaaatttcc aggcattatg gtttacagag atgattattt catcagacat      480

tccatctctg tatctgcagt gatagtacgc gcctggatta ctcacaaata cagtggcaga      540

gactggaatg ttaaatggga ggaaaacttg ctccatgctg tagcaaagaa ttataccctc      600

ctgcagacca tcccgccttt tgaacgccct ttcaaagatc atcaagtgtg ccttgagtgg      660

aacatgggtt atatttggaa ccttcgggca aacaggattc cacagtgtcc tctggaaaat      720

gatgtggttg ccctgcttgg ctttccttat gcctccagtg gagaaaacac aggcattgtc      780

aagaagttcc cgaggtttcg gaaccgagag ctggaggcca ctcgacgcca gaggatggat      840

tacccagtgt ttactgtttc attgtggctt tatttactcc attattgcaa ggccaacctc      900

tgtgggattc tgtactttgt tgactctaat gagatgtacg gcacaccttc tgtatttctt      960

acggaagagg gctatttgca tattcagatg catcttgtca aaggggaaga ccttgctgta     1020

aaaactaaat tcatcatacc tttgaaggag tggtttcgac tggatatctc ttttaacgga     1080

ggccagatag tagtaaccac tagcattgga caggatttga aaagctacca caatcagacc     1140

attagcttcc gggaggattt ccattataat gacacagctg ggtacttcat tattggaggg     1200

agcaggtatg tggctggcat tgaagggttt tttggacccc tgaagtacta tcgccttcgc     1260

agtctgcacc ccgcccagat ttttaatccc ctccttgaga agcaacttgc tgaacaaatc     1320

aagttatatt atgaaaggtg tgctgaggtt caagaaatag tatctgtgta tgcatctgca     1380

gcaaagcacg ggggcgagag acaagaagca tgccacctcc acaactccta cctggacctc     1440

cagcgcaggt atgggagacc ctcgatgtgc agagccttcc cctgggagaa ggagctgaaa     1500

gacaaacacc ccagcttgtt ccaggcattg ctggagatgg atctgctgac cgtgccaagg     1560

aaccaaaatg aatctgtatc agaaatcggt gggaagatat ttgagaaggc tgtaaagaga     1620

ctctctagca ttgatggtct tcaccaaatt agctctatcg tcccctttct gacggattcc     1680

agctgctgtg gataccataa agcatcctac taccttgcag tcttttatga gactggatta     1740

aatgttcctc gggatcagct gcagggcatg ttgtatagtt tggttggagg ccaggggagt     1800

gagaggctgt cttcaatgaa tcttgggtat aaacactacc agggtattga caactacccc     1860

ctggactggg aactgtcgta tgcctactac agcaacattg ccaccaagac accccttgac     1920

cagcacacac tgcaaggaga tcaggcatat gttgaaacaa ttagactaaa agatgatgaa     1980

atactcaagg tacaaaccaa agaagatgga gatgtcttta tgtggttgaa gcatgaagct     2040

acccgaggca atgcagcagc tcagcaacga ttggcccaga tgctgttctg ggggcagcaa     2100

ggtgtggcca agaatcccga agcagcaatt gagtggtacg ccaagggcgc cctggagacg     2160

gaggatcctg cgttaatcta tgactatgcc attgtgctat tcaagggtca aggagtaaaa     2220

aagaacagac ggcttgcctt agagctgatg aagaaagcag cttccaaggg attgcatcag     2280

gcagtcaatg gcctgggatg gtattaccac aaattcaaga aaaattacgc caaagcagca     2340

aagtactggt taaaagcaga agaaatgggg aacccagatg cgtcatacaa tcttggagtc     2400

ctgcatttgg atggcatctt ccctggagtt cctggaagga atcaaacttt agctggtgaa     2460

attttccata aggctgcgca aggtggacac atggaaggga ccttgtggtg ttctctctac     2520

tatatcacag gcaacctgga gacattccct agagatcctg agaaagctgt tgtatgggca     2580

aaacatgtag ctgagaaaaa tggctacttg ggccatgtca tccgcaaagg cctcaatgcc     2640

tacctggaag gttcatggca tgaagctttg ctgtattatg ttttagcagc agaaactgga     2700

attgaagtgt cacagacaaa tttagcacac atctgtgagg agaggccaga cctggccagg     2760

agatacttgg gtgttaactg tgtttggaga tactataatt tctctgtttt tcaaatcgat     2820

gctccttcct ttgcatattt gaagatggga gacctttact actatggcca ccaaaaccag     2880

tcacaagacc tggagttgtc tgtgcagatg tacgcccaag ccgccctgga tggagactcc     2940

cagggatttt ttaacctggc cctgctaatc gaggaaggta cgataatccc acaccatatc     3000

ttggatttct tggaaattga ctcaactctc cattctaata acatctccat tctccaggaa     3060

ctgtacgaaa ggtgctggag ccacagtaac gaggagtcct tcagcccctg ctccttggcc     3120

tggctttacc tgcacttgcg gcttctctgg ggtgctatcc tgcactcagc cctgatctac     3180

tttctgggaa cctttctgct atccatattg atcgcctgga ctgtgcagta tttccagtct     3240

gtctcagcaa gcgatccccc tccaagacca tcccaggcct ccccagacac tgccacatcc     3300

actgcaagtc cagctgtgac tccagctgca gatgcctctg accaagacca gcccacagta     3360

actaataacc cggagccacg tgggtgaact gtgcactcca gttctctcca gatgagagag     3420

aatcttttca acagctggta ttgggaagct ggggccaggg catgatcctg ataaacacct     3480

taaatgtctt gtcaactgga tgcaaatttt gcaattggtg tcattttttt taaagtcaaa     3540

ttacaaggaa gtacccagat caggcagtgg taataccaaa ggtcatcaaa cacatacaag     3600

gaacatcttg atcatagggc atgtggggaa gtttactggg ccatcacaga cttttgttct     3660

agtgattgta tgtattagga gtcatagcat gccctacggc agatctggat tcttatacac     3720

taagatgtgt cttaagaatc acagtgcgtg cttcatccct ttattgaaga acagaaaatt     3780

atgactactc tacaaggtgg ataatatttt ggtacctgtg cttgccacag ccctgttcct     3840

caaagctgaa ttgatagatt tctctttgac ttccaagacc tagcagttat aaggcacctt     3900

gaaataaatt gtttgtgcct ggaaatgcag ggagggcaat agctttgtaa attggtttac     3960

atttttctcc ttgaattttt ctagggtcct agtgcttccg aatcatttaa tggcattgtc     4020

ggatatcttt tacatttcaa ttgcaatcca tgaaattaca tttagaagat tcttagtact     4080

taactgtagt cttctccatg aattacacgt tagaatagac tggcagcaac ggaatatgca     4140

gcaagtaagc ctctagctta tagtttcatc cctacccctc atgcctgcgt gagtctgtac     4200

agggatatgt gtgtgtgtgt gtgtgtgtgt gtgttagaga ggaagaggaa gagcagaatg     4260

tctgtatact acatgctgct aaggtagtga ataaatcagt aatgcaatat tgtgggtcca     4320

aactactctt tgcactactt tatttacagt agtaaataaa attattttta tacaattgac     4380

taccaaaaaa aaaaaaaaaa                                                 4400


<210>  300
<211>  979
<212>  PRT
<213>  Homo Sapiens

<400>  300

Met Val Tyr Arg Asp Asp Tyr Phe Ile Arg His Ser Ile Ser Val Ser 
1               5                   10                  15      


Ala Val Ile Val Arg Ala Trp Ile Thr His Lys Tyr Ser Gly Arg Asp 
            20                  25                  30          


Trp Asn Val Lys Trp Glu Glu Asn Leu Leu His Ala Val Ala Lys Asn 
        35                  40                  45              


Tyr Thr Leu Leu Gln Thr Ile Pro Pro Phe Glu Arg Pro Phe Lys Asp 
    50                  55                  60                  


His Gln Val Cys Leu Glu Trp Asn Met Gly Tyr Ile Trp Asn Leu Arg 
65                  70                  75                  80  


Ala Asn Arg Ile Pro Gln Cys Pro Leu Glu Asn Asp Val Val Ala Leu 
                85                  90                  95      


Leu Gly Phe Pro Tyr Ala Ser Ser Gly Glu Asn Thr Gly Ile Val Lys 
            100                 105                 110         


Lys Phe Pro Arg Phe Arg Asn Arg Glu Leu Glu Ala Thr Arg Arg Gln 
        115                 120                 125             


Arg Met Asp Tyr Pro Val Phe Thr Val Ser Leu Trp Leu Tyr Leu Leu 
    130                 135                 140                 


His Tyr Cys Lys Ala Asn Leu Cys Gly Ile Leu Tyr Phe Val Asp Ser 
145                 150                 155                 160 


Asn Glu Met Tyr Gly Thr Pro Ser Val Phe Leu Thr Glu Glu Gly Tyr 
                165                 170                 175     


Leu His Ile Gln Met His Leu Val Lys Gly Glu Asp Leu Ala Val Lys 
            180                 185                 190         


Thr Lys Phe Ile Ile Pro Leu Lys Glu Trp Phe Arg Leu Asp Ile Ser 
        195                 200                 205             


Phe Asn Gly Gly Gln Ile Val Val Thr Thr Ser Ile Gly Gln Asp Leu 
    210                 215                 220                 


Lys Ser Tyr His Asn Gln Thr Ile Ser Phe Arg Glu Asp Phe His Tyr 
225                 230                 235                 240 


Asn Asp Thr Ala Gly Tyr Phe Ile Ile Gly Gly Ser Arg Tyr Val Ala 
                245                 250                 255     


Gly Ile Glu Gly Phe Phe Gly Pro Leu Lys Tyr Tyr Arg Leu Arg Ser 
            260                 265                 270         


Leu His Pro Ala Gln Ile Phe Asn Pro Leu Leu Glu Lys Gln Leu Ala 
        275                 280                 285             


Glu Gln Ile Lys Leu Tyr Tyr Glu Arg Cys Ala Glu Val Gln Glu Ile 
    290                 295                 300                 


Val Ser Val Tyr Ala Ser Ala Ala Lys His Gly Gly Glu Arg Gln Glu 
305                 310                 315                 320 


Ala Cys His Leu His Asn Ser Tyr Leu Asp Leu Gln Arg Arg Tyr Gly 
                325                 330                 335     


Arg Pro Ser Met Cys Arg Ala Phe Pro Trp Glu Lys Glu Leu Lys Asp 
            340                 345                 350         


Lys His Pro Ser Leu Phe Gln Ala Leu Leu Glu Met Asp Leu Leu Thr 
        355                 360                 365             


Val Pro Arg Asn Gln Asn Glu Ser Val Ser Glu Ile Gly Gly Lys Ile 
    370                 375                 380                 


Phe Glu Lys Ala Val Lys Arg Leu Ser Ser Ile Asp Gly Leu His Gln 
385                 390                 395                 400 


Ile Ser Ser Ile Val Pro Phe Leu Thr Asp Ser Ser Cys Cys Gly Tyr 
                405                 410                 415     


His Lys Ala Ser Tyr Tyr Leu Ala Val Phe Tyr Glu Thr Gly Leu Asn 
            420                 425                 430         


Val Pro Arg Asp Gln Leu Gln Gly Met Leu Tyr Ser Leu Val Gly Gly 
        435                 440                 445             


Gln Gly Ser Glu Arg Leu Ser Ser Met Asn Leu Gly Tyr Lys His Tyr 
    450                 455                 460                 


Gln Gly Ile Asp Asn Tyr Pro Leu Asp Trp Glu Leu Ser Tyr Ala Tyr 
465                 470                 475                 480 


Tyr Ser Asn Ile Ala Thr Lys Thr Pro Leu Asp Gln His Thr Leu Gln 
                485                 490                 495     


Gly Asp Gln Ala Tyr Val Glu Thr Ile Arg Leu Lys Asp Asp Glu Ile 
            500                 505                 510         


Leu Lys Val Gln Thr Lys Glu Asp Gly Asp Val Phe Met Trp Leu Lys 
        515                 520                 525             


His Glu Ala Thr Arg Gly Asn Ala Ala Ala Gln Gln Arg Leu Ala Gln 
    530                 535                 540                 


Met Leu Phe Trp Gly Gln Gln Gly Val Ala Lys Asn Pro Glu Ala Ala 
545                 550                 555                 560 


Ile Glu Trp Tyr Ala Lys Gly Ala Leu Glu Thr Glu Asp Pro Ala Leu 
                565                 570                 575     


Ile Tyr Asp Tyr Ala Ile Val Leu Phe Lys Gly Gln Gly Val Lys Lys 
            580                 585                 590         


Asn Arg Arg Leu Ala Leu Glu Leu Met Lys Lys Ala Ala Ser Lys Gly 
        595                 600                 605             


Leu His Gln Ala Val Asn Gly Leu Gly Trp Tyr Tyr His Lys Phe Lys 
    610                 615                 620                 


Lys Asn Tyr Ala Lys Ala Ala Lys Tyr Trp Leu Lys Ala Glu Glu Met 
625                 630                 635                 640 


Gly Asn Pro Asp Ala Ser Tyr Asn Leu Gly Val Leu His Leu Asp Gly 
                645                 650                 655     


Ile Phe Pro Gly Val Pro Gly Arg Asn Gln Thr Leu Ala Gly Glu Ile 
            660                 665                 670         


Phe His Lys Ala Ala Gln Gly Gly His Met Glu Gly Thr Leu Trp Cys 
        675                 680                 685             


Ser Leu Tyr Tyr Ile Thr Gly Asn Leu Glu Thr Phe Pro Arg Asp Pro 
    690                 695                 700                 


Glu Lys Ala Val Val Trp Ala Lys His Val Ala Glu Lys Asn Gly Tyr 
705                 710                 715                 720 


Leu Gly His Val Ile Arg Lys Gly Leu Asn Ala Tyr Leu Glu Gly Ser 
                725                 730                 735     


Trp His Glu Ala Leu Leu Tyr Tyr Val Leu Ala Ala Glu Thr Gly Ile 
            740                 745                 750         


Glu Val Ser Gln Thr Asn Leu Ala His Ile Cys Glu Glu Arg Pro Asp 
        755                 760                 765             


Leu Ala Arg Arg Tyr Leu Gly Val Asn Cys Val Trp Arg Tyr Tyr Asn 
    770                 775                 780                 


Phe Ser Val Phe Gln Ile Asp Ala Pro Ser Phe Ala Tyr Leu Lys Met 
785                 790                 795                 800 


Gly Asp Leu Tyr Tyr Tyr Gly His Gln Asn Gln Ser Gln Asp Leu Glu 
                805                 810                 815     


Leu Ser Val Gln Met Tyr Ala Gln Ala Ala Leu Asp Gly Asp Ser Gln 
            820                 825                 830         


Gly Phe Phe Asn Leu Ala Leu Leu Ile Glu Glu Gly Thr Ile Ile Pro 
        835                 840                 845             


His His Ile Leu Asp Phe Leu Glu Ile Asp Ser Thr Leu His Ser Asn 
    850                 855                 860                 


Asn Ile Ser Ile Leu Gln Glu Leu Tyr Glu Arg Cys Trp Ser His Ser 
865                 870                 875                 880 


Asn Glu Glu Ser Phe Ser Pro Cys Ser Leu Ala Trp Leu Tyr Leu His 
                885                 890                 895     


Leu Arg Leu Leu Trp Gly Ala Ile Leu His Ser Ala Leu Ile Tyr Phe 
            900                 905                 910         


Leu Gly Thr Phe Leu Leu Ser Ile Leu Ile Ala Trp Thr Val Gln Tyr 
        915                 920                 925             


Phe Gln Ser Val Ser Ala Ser Asp Pro Pro Pro Arg Pro Ser Gln Ala 
    930                 935                 940                 


Ser Pro Asp Thr Ala Thr Ser Thr Ala Ser Pro Ala Val Thr Pro Ala 
945                 950                 955                 960 


Ala Asp Ala Ser Asp Gln Asp Gln Pro Thr Val Thr Asn Asn Pro Glu 
                965                 970                 975     


Pro Arg Gly 
            


<210>  301
<211>  2272
<212>  DNA
<213>  Homo Sapiens

<400>  301
attgctgtgt caagttccag agaaaagctt ctgttcgtcc aagttactaa ccaggctaaa       60

ccacatagac gtgaaggaag gggctagaag gaagggagtg ccccactgtt gatggggtaa      120

gaggatcctg tactgagaag ttgaccagag agggtctcac catgcgcaca gttccttctg      180

tacctgtgtg gaggaaaagt actgagtgaa gggcagaaaa agagaaaaca gaaatgctct      240

gcccttggag aactgctaac ctagggctac tgttgatttt gactatcttc ttagtggccg      300

aagcggaggg tgctgctcaa ccaaacaact cattaatgct gcaaactagc aaggagaatc      360

atgctttagc ttcaagcagt ttatgtatgg atgaaaaaca gattacacag aactactcga      420

aagtactcgc agaagttaac acttcatggc ctgtaaagat ggctacaaat gctgtgcttt      480

gttgccctcc tatcgcatta agaaatttga tcataataac atgggaaata atcctgagag      540

gccagccttc ctgcacaaaa gcctacaaga aagaaacaaa tgagaccaag gaaaccaact      600

gtactgatga gagaataacc tgggtctcca gacctgatca gaattcggac cttcagattc      660

gtaccgtggc catcactcat gacgggtatt acagatgcat aatggtaaca cctgatggga      720

atttccatcg tggatatcac ctccaagtgt tagttacacc tgaagtgacc ctgtttcaaa      780

acaggaatag aactgcagta tgcaaggcag ttgcagggaa gccagctgcg catatctcct      840

ggatcccaga gggcgattgt gccactaagc aagaatactg gagcaatggc acagtgactg      900

ttaagagtac atgccactgg gaggtccaca atgtgtctac cgtgacctgc cacgtctccc      960

atttgactgg caacaagagt ctgtacatag agctacttcc tgttccaggt gccaaaaaat     1020

cagcaaaatt atatattcca tatatcatcc ttactattat tattttgacc atcgtgggat     1080

tcatttggtt gttgaaagtc aatggctgca gaaaatataa attgaataaa acagaatcta     1140

ctccagttgt tgaggaggat gaaatgcagc cctatgccag ctacacagag aagaacaatc     1200

ctctctatga tactacaaac aaggtgaagg catctgaggc attacaaagt gaagttgaca     1260

cagacctcca tactttataa gttgttggac tctagtacca agaaacaaca acaaacgaga     1320

tacattataa ttactgtctg attttcttac agttctagaa tgaagactta tattgaaatt     1380

aggttttcca aggttcttag aagacatttt aatggattct cattcatacc cttgtataat     1440

tggaattttt gattcttagc tgctaccagc tagttctctg aagaactgat gttattacaa     1500

agaaaataca tgcccatgac caaatattca aattgtgcag gacagtaaat aatgaaaacc     1560

aaatttcctc aagaaataac tgaagaagga gcaagtgtga acagtttctt gtgtatcctt     1620

tcagaatatt ttaatgtaca tatgacatgt gtatatgcct atggtatatg tgtcaattta     1680

tgtgtcccct tacatataca tgcacatatc tttgtcaagg caccagtggg aacaatacac     1740

tgcattactg ttctatacat atgaaaacct aataatataa gtcttagaga tcattttata     1800

tcatgacaag tagagctacc tcattctttt taatggttat ataaaattcc attgtatagt     1860

tatatcatta tttaattaaa aacaacccta atgatggata tttagattct tttaagtttt     1920

gtttatttct tttaagtttt gtttgtggta taaacaatac cacatagaat gtttcttgtg     1980

catatatctc tttgtttttg agtatatctg taggataact ttcttgagtg gaattgtcag     2040

gtcaaagggt ttgtgcattt tactattgat atatatgtta aattgtgtca aatatatatg     2100

tcaaattccc tccaacattg tttaaatgtg cctttcccta aatttctatt ttaataactg     2160

tactattcct gcttctacag ttgccacttt ctctttttaa tcaaccagat taaatatgat     2220

gtgagattat aataagaatt atactattta ataaaaatgg atttatattt tt             2272


<210>  302
<211>  348
<212>  PRT
<213>  Homo Sapiens

<400>  302

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro 
                165                 170                 175     


Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala 
            180                 185                 190         


Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp 
        195                 200                 205             


Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys 
    210                 215                 220                 


Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His 
225                 230                 235                 240 


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
                245                 250                 255     


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile 
            260                 265                 270         


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
        275                 280                 285             


Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro 
    290                 295                 300                 


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala 
                325                 330                 335     


Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
            340                 345             


<210>  303
<211>  3572
<212>  DNA
<213>  Homo Sapiens

<400>  303
gcctttctgg ggcctggggg atcctcttgc actggtgggt ggagagaagc gcctgcagcc       60

aaccagggtc aggctgtgct cacagtttcc tctggcggca tgtaaaggct ccacaaagga      120

gttgggagtt caaatgaggc tgctgcggac ggcctgagga tggaccccaa gccctggacc      180

tgccgagcgt ggcactgagg cagcggctga cgctactgtg agggaaagaa ggttgtgagc      240

agccccgcag gacccctggc cagccctggc cccagcctct gccggagccc tctgtggagg      300

cagagccagt ggagcccagt gaggcagggc tgcttggcag ccaccggcct gcaactcagg      360

aacccctcca gaggccatgg acaggctgcc ccgctgacgg ccagggtgaa gcatgtgagg      420

agccgccccg gagccaagca ggagggaaga ggctttcata gattctattc acaaagaata      480

accaccattt tgcaaggacc atgaggccac tgtgcgtgac atgctggtgg ctcggactgc      540

tggctgccat gggagctgtt gcaggccagg aggacggttt tgagggcact gaggagggct      600

cgccaagaga gttcatttac ctaaacaggt acaagcgggc gggcgagtcc caggacaagt      660

gcacctacac cttcattgtg ccccagcagc gggtcacggg tgccatctgc gtcaactcca      720

aggagcctga ggtgcttctg gagaaccgag tgcataagca ggagctagag ctgctcaaca      780

atgagctgct caagcagaag cggcagatcg agacgctgca gcagctggtg gaggtggacg      840

gcggcattgt gagcgaggtg aagctgctgc gcaaggagag ccgcaacatg aactcgcggg      900

tcacgcagct ctacatgcag ctcctgcacg agatcatccg caagcgggac aacgcgttgg      960

agctctccca gctggagaac aggatcctga accagacagc cgacatgctg cagctggcca     1020

gcaagtacaa ggacctggag cacaagtacc agcacctggc cacactggcc cacaaccaat     1080

cagagatcat cgcgcagctt gaggagcact gccagagggt gccctcggcc aggcccgtcc     1140

cccagccacc ccccgctgcc ccgccccggg tctaccaacc acccacctac aaccgcatca     1200

tcaaccagat ctctaccaac gagatccaga gtgaccagaa cctgaaggtg ctgccacccc     1260

ctctgcccac tatgcccact ctcaccagcc tcccatcttc caccgacaag ccgtcgggcc     1320

catggagaga ctgcctgcag gccctggagg atggccacga caccagctcc atctacctgg     1380

tgaagccgga gaacaccaac cgcctcatgc aggtgtggtg cgaccagaga cacgaccccg     1440

ggggctggac cgtcatccag agacgcctgg atggctctgt taacttcttc aggaactggg     1500

agacgtacaa gcaagggttt gggaacattg acggcgaata ctggctgggc ctggagaaca     1560

tttactggct gacgaaccaa ggcaactaca aactcctggt gaccatggag gactggtccg     1620

gccgcaaagt ctttgcagaa tacgccagtt tccgcctgga acctgagagc gagtattata     1680

agctgcggct ggggcgctac catggcaatg cgggtgactc ctttacatgg cacaacggca     1740

agcagttcac caccctggac agagatcatg atgtctacac aggaaactgt gcccactacc     1800

agaagggagg ctggtggtat aacgcctgtg cccactccaa cctcaacggg gtctggtacc     1860

gcgggggcca ttaccggagc cgctaccagg acggagtcta ctgggctgag ttccgaggag     1920

gctcttactc actcaagaaa gtggtgatga tgatccgacc gaaccccaac accttccact     1980

aagccagctc cccctcctga cctctcgtgg ccattgccag gagcccaccc tggtcacgct     2040

ggccacagca caaagaacaa ctcctcacca gttcatcctg aggctgggag gaccgggatg     2100

ctggattctg ttttccgaag tcactgcagc ggatgatgga actgaatcga tacggtgttt     2160

tctgtccctc ctactttcct tcacaccaga cagcccctca tgtctccagg acaggacagg     2220

actacagaca actctttctt taaataaatt aagtctctac aataaaaaca caactgcaaa     2280

gtaccttcat aatatacatg tgtatgagcc tcccttgtgc acgtatgtgt ataccacata     2340

tatatgcatt tagatataca tcacatgtga tatatctaga tccatatata ggtttgcctt     2400

agatacctaa atacacatat attcagttct cagatgttga agctgtcacc agcagctttg     2460

ctcttaggag aaaagcattt cattagtgtt gtattacttg agtctaaggg tagatcacag     2520

actgtgtggt ctcaactgaa aggatcaccc ttggcatctg tgtgcctgga ttcttccaga     2580

atgtctacaa tgctaatctc tcacatagag gttcccagct tcttaagaac cccttttggc     2640

acctaatcaa atttcaaaat ccctcccccc acattttcat acttttcccc attctcagga     2700

cttttcacca tccatcaccc acttatccct tcatttgaca ccattcatta agtgccttct     2760

gtgtgtcagt ccctggccac tcactgcagt tcaaggcccc ctttccgctc tgctgtactc     2820

ctcgcctacc tactccttgc cttttctgtc gcacagcccc ttctttccag gcgagattcc     2880

tcagcttctg agtaggaaac actccgggct ccaggtttct ggttgggaag ggaaggccag     2940

gccaaaagct ccaccggccg tatagataat gtactcgcag ttttgtatct tccattcata     3000

ctttaaccta caggtcattt gagtcttcac acaaataata acctatctgg ccaggagaat     3060

tatctcagaa cagaagtcat cagatcatca gagcccccag atggctacag accagagatt     3120

ccacgctctc aggctgacta gagtccgcat ctcatctcca aactacactt ccctggagaa     3180

caagtgccac aaaaatgaaa acaggccact tctcaggagt tgaataatca ggggtcaccg     3240

gaccccttgg ttgatgcact gcagcatggt ggctttctga gtcctgttgg ccaccaagtg     3300

tcagcctcag cactcccggg actattgcca agaaggggca agggatgagt caagaaggtg     3360

agacccttcc cggtgggcac gtgggccagg ctgtgtgaga tgttggatgt ttggtactgt     3420

ccatgtctgg gtgtgtgcct attacctcag catttctcac aaagtgtacc atgtagcatg     3480

ttttgtgtat ataaaaggga gggttttttt aaaaatatat tcccagatta tccttgtaat     3540

gacacgaatc tgcaataaaa gccatcagtg ct                                   3572


<210>  304
<211>  493
<212>  PRT
<213>  Homo Sapiens

<400>  304

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  305
<211>  1074
<212>  DNA
<213>  Homo Sapiens

<400>  305
gatcaacaca tttcatctgg gcttcttaaa tctaaatctt taaaatgact aagttttctt       60

ccttttctct gtttttccta atagttgggg cttatatgac tcatgtgtgt ttcaatatgg      120

aaattattgg agggaaagaa gtgtcacctc attccaggcc atttatggcc tccatccagt      180

atggcggaca tcacgtttgt ggaggtgttc tgattgatcc acagtgggtg ctgacagcag      240

cccactgcca atatcggttt accaaaggcc agtctcccac tgtggtttta ggcgcacact      300

ctctctcaaa gaatgaggcc tccaaacaaa cactggagat caaaaaattt ataccattct      360

caagagttac atcagatcct caatcaaatg atatcatgct ggttaagctt caaacagccg      420

caaaactcaa taaacatgtc aagatgctcc acataagatc caaaacctct cttagatctg      480

gaaccaaatg caaggttact ggctggggag ccaccgatcc agattcatta agaccttctg      540

acaccctgcg agaagtcact gttactgtcc taagtcgaaa actttgcaac agccaaagtt      600

actacaacgg cgaccctttt atcaccaaag acatggtctg tgcaggagat gccaaaggcc      660

agaaggattc ctgtaagggt gactcagggg gccccttgat ctgtaaaggt gtcttccacg      720

ctatagtctc tggaggtcat gaatgtggtg ttgccacaaa gcctggaatc tacaccctgt      780

taaccaagaa ataccagact tggatcaaaa gcaaccttgt cccgcctcat acaaattaag      840

ttacaaataa ttttattgga tgcacttgct tcttttttcc taatatgctc gcaggttaga      900

gttgggtgta agtaaagcag agcacatatg gggtccattt ttgcacttgt aagtcatttt      960

attaaggaat caagttcttt ttcacttgta tcactgatgt atttctacca tgctggtttt     1020

attctaaata aaatttagaa gactcaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           1074


<210>  306
<211>  264
<212>  PRT
<213>  Homo Sapiens

<400>  306

Met Thr Lys Phe Ser Ser Phe Ser Leu Phe Phe Leu Ile Val Gly Ala 
1               5                   10                  15      


Tyr Met Thr His Val Cys Phe Asn Met Glu Ile Ile Gly Gly Lys Glu 
            20                  25                  30          


Val Ser Pro His Ser Arg Pro Phe Met Ala Ser Ile Gln Tyr Gly Gly 
        35                  40                  45              


His His Val Cys Gly Gly Val Leu Ile Asp Pro Gln Trp Val Leu Thr 
    50                  55                  60                  


Ala Ala His Cys Gln Tyr Arg Phe Thr Lys Gly Gln Ser Pro Thr Val 
65                  70                  75                  80  


Val Leu Gly Ala His Ser Leu Ser Lys Asn Glu Ala Ser Lys Gln Thr 
                85                  90                  95      


Leu Glu Ile Lys Lys Phe Ile Pro Phe Ser Arg Val Thr Ser Asp Pro 
            100                 105                 110         


Gln Ser Asn Asp Ile Met Leu Val Lys Leu Gln Thr Ala Ala Lys Leu 
        115                 120                 125             


Asn Lys His Val Lys Met Leu His Ile Arg Ser Lys Thr Ser Leu Arg 
    130                 135                 140                 


Ser Gly Thr Lys Cys Lys Val Thr Gly Trp Gly Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Ser Leu Arg Pro Ser Asp Thr Leu Arg Glu Val Thr Val Thr Val Leu 
                165                 170                 175     


Ser Arg Lys Leu Cys Asn Ser Gln Ser Tyr Tyr Asn Gly Asp Pro Phe 
            180                 185                 190         


Ile Thr Lys Asp Met Val Cys Ala Gly Asp Ala Lys Gly Gln Lys Asp 
        195                 200                 205             


Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys Lys Gly Val Phe 
    210                 215                 220                 


His Ala Ile Val Ser Gly Gly His Glu Cys Gly Val Ala Thr Lys Pro 
225                 230                 235                 240 


Gly Ile Tyr Thr Leu Leu Thr Lys Lys Tyr Gln Thr Trp Ile Lys Ser 
                245                 250                 255     


Asn Leu Val Pro Pro His Thr Asn 
            260                 


<210>  307
<211>  2918
<212>  DNA
<213>  Homo Sapiens

<400>  307
gcggccgcct gcgcgctggc cgcctgcgcg ctgccagccc gcccgcccgc caggggctcc       60

gccgccctcg cctcggcctc gttagcccgc caggagcccc gcagctcctc cgggagcccg      120

ctggtaactc gcgtccctcg cgcttctccg gcgcctgagg ggcccgcctc gggccatggt      180

gctctcccag gaggagccgg actccgcgcg gggcacgagc gaggcgcagc cgctcggccc      240

cgcgcccacg ggggccgctc cgccgcccgg cccgggaccc tcggacagcc ccgaggcggc      300

tgtcgagaag gtggaggtgg agctggcggg gccggcgacc gcggagcccc atgagccccc      360

cgaacccccc gagggcggct ggggctggct ggtgatgctg gcggccatgt ggtgcaacgg      420

gtcggtgttc ggcatccaga acgcttgcgg ggtgctcttc gtgtccatgc tggaaacctt      480

cggctccaaa gacgatgaca agatggtctt taagacagca tgggtaggtt ctctctccat      540

ggggatgatt ttcttttgct gcccaatagt cagcgtcttc acagacctat ttggttgtcg      600

gaaaacagct gtcgtgggtg ctgctgttgg atttgttggg ctcatgtcca gttcttttgt      660

aagttccatc gagcctctgt accttaccta tggaatcata tttgcctgcg gctgctcctt      720

tgcataccag ccttcattgg tcattttggg acactatttc aagaagcgcc ttggactggt      780

gaatggcatt gtcactgctg gcagcagtgt cttcacaatc ctgctgcctt tgctcttaag      840

ggttctgatt gacagcgtgg gcctctttta cacattgagg gtgctctgca tcttcatgtt      900

tgttctcttt ctggctggct ttacttaccg acctcttgct accagtacca aagataaaga      960

gagtggaggt agcggatcct ccctcttttc caggaaaaag ttcagtcctc caaaaaaaat     1020

tttcaatttt gccatcttca aggtgacagc ttatgcagtg tgggcagttg gaataccact     1080

tgcacttttt ggatactttg tgccttatgt tcacttgatg aaacatgtaa atgaaagatt     1140

tcaagatgaa aaaaataaag aggttgttct catgtgcatt ggcgtcactt caggagttgg     1200

acgactgctc tttggccgga ttgcagatta tgtgcctggt gtgaagaagg tttatctaca     1260

ggtactctcc tttttcttca ttggtctgat gtccatgatg attcctctgt gtagcatctt     1320

tggggccctc attgctgtgt gcctcatcat gggtctcttc gatggatgct tcatttccat     1380

tatggctccc atagcctttg agttagttgg tgcccaggat gtctcccaag caattggatt     1440

tctgctcgga ttcatgtcta tacccatgac tgttggccca cccattgcag ggttacttcg     1500

tgacaaactg ggctcctatg atgtggcatt ctacctcgct ggagtccctc cccttattgg     1560

aggtgctgtg ctttgtttta tcccgtggat ccatagtaag aagcaaagag agatcagtaa     1620

aaccactgga aaagaaaaga tggagaaaat gttggaaaac cagaactctc tgctgtcaag     1680

ttcatctgga atgttcaaga aagaatctga ctctattatt taatatctta catacctcca     1740

ccagactgga cttgcttttt gaattttaag caagtttcct ttccttttat acaaattgca     1800

aatttcatat ttttttaatc acatcctagg aatagcacaa taattgggaa atagaaccct     1860

tatcactaga agaaccattt tctgccacta aatatctctg atgtttccat gagtctgagg     1920

gcagagactc tggtatatga aaacgtctga aagtcacata ttgtgaaaat ttgaagctat     1980

ctcagtaaaa agcagctttg gaaactgtga atgatcttta gcttgtacaa atgtttaaaa     2040

atacctcagg ctatactgaa agggttgcag tttggttagg agtggaaata ttttgtttgt     2100

taatgatgtc ttcagttctg gtacctctgt tttactttct tatgctcttt ggaaactttt     2160

tgcaaaattt aagcctgggt tctagataat accagatcta cctaaacctc aagtctatgt     2220

taaagttgct ttcctgctgt taaataagct atgatattaa gatattctga cttgctccag     2280

tgtcaaggga ccttctggga gcaggtgcta acatagtgtt cagaatcaat atgtgagatg     2340

aaaaggatcc cctccaggag gatcctgagc tgttcagaaa tcatttaagt ttacagcgtt     2400

gttccctttg cgtttgcagt gcgttttact caagtagcca gaaacacccc acgtttctga     2460

atttgtttaa actgtaacaa taaagtaaaa tagaatgcat gaaagatatt ctggcgattg     2520

taacttagaa tttttctgac ttctggattt gttggcacta gaacctgata tttaaagtct     2580

tactgagcag ctatcaagtg gcagttacag gcacaaattg gtggaggctg gaggatgggg     2640

aggggagcaa aaccctttat atttgtgaag aaaatatctg tagctgatag aaataattgc     2700

ttaaattggt ttatgaaatt aatgagtctg aaaaggttaa aagcacttat aaaaagaacc     2760

aagtcctaca tttccagaac tttctggcaa aaatttgcac tcatattatt tatcctatga     2820

acattcccat tgtttttttt tgctatttat atacagatta tcataagaaa gctctcagtt     2880

tgaggaccca aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             2918


<210>  308
<211>  515
<212>  PRT
<213>  Homo Sapiens

<400>  308

Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      


Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              


Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  


Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  


Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      


Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         


Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             


Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 


Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 


Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     


Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         


His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             


Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 


Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 


Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     


Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         


Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             


Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 


Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 


Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     


Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         


Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             


Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 


Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 


Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     


Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         


Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             


Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 


Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 


Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     


Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         


Ser Ile Ile 
        515 


<210>  309
<211>  4304
<212>  DNA
<213>  Homo Sapiens

<400>  309
cttgggcgtt ggaccccgca tcttattagc aaccagggag atttctccat tttcctcttg       60

tctacagtgc ggctacaaat ctgggatttt tttattactt cttttttttt cgaactacac      120

ttgggctcct ttttttgtgc tcgacttttc cacccttttt ccctccctcc tgtgctgctg      180

ctttttgatc tcttcgacta aaattttttt atccggagtg tatttaatcg gttctgttct      240

gtcctctcca ccacccccac ccccctccct ccggtgtgtg tgccgctgcc gctgttgccg      300

ccgccgctgc tgctgctcgc cccgtcgtta caccaacccg aggctctttg tttcccctct      360

tggatctgtt gagtttcttt gttgaagaag ccagcatggg tgcccagttc tccaagaccg      420

cagcgaaggg agaagccgcc gcggagaggc ctggggaggc ggctgtggcc tcgtcgcctt      480

ccaaagcgaa cggacaggag aatggccacg tgaaggtaaa cggcgacgct tcgcccgcgg      540

ccgccgagtc gggcgccaag gaggagctgc aggccaacgg cagcgccccg gccgccgaca      600

aggaggagcc cgcggccgcc gggagcgggg cggcgtcgcc ctccgcggcc gagaaaggtg      660

agccggccgc cgccgctgcc cccgaggccg gggccagccc ggtagagaag gaggcccccg      720

cggaaggcga ggctgccgag cccggctcgc ccacggccgc ggagggagag gccgcgtcgg      780

ccgcctcctc gacttcttcg cccaaggccg aggacggggc cacgccctcg cccagcaacg      840

agaccccgaa aaaaaaaaag aagcgctttt ccttcaagaa gtctttcaag ctgagcggct      900

tctccttcaa gaagaacaag aaggaggctg gagaaggcgg tgaggctgag gcgcccgctg      960

ccgaaggcgg caaggacgag gccgccgggg gcgcagctgc ggccgccgcc gaggcgggcg     1020

cggcctccgg ggagcaggca gcggcgccgg gcgaggaggc ggcagcgggc gaggaggggg     1080

cggcgggtgg cgacccgcag gaggccaagc cccaggaggc cgctgtcgcg ccagagaagc     1140

cgcccgccag cgacgagacc aaggccgccg aggagcccag caaggtggag gagaaaaagg     1200

ccgaggaggc cggggccagc gccgccgcct gcgaggcccc ctccgccgcc gggcccggcg     1260

cgcccccgga gcaggaggca gcccccgcgg aggagcccgc ggccgccgca gcctcgtcag     1320

cctgcgcagc cccctcacag gaggcccagc ccgagtgcag tccagaagcc cccccagcgg     1380

aggcggcaga gtaaaagagc aagcttttgt gagataatcg aagaactttt ctcccccgtt     1440

tgtttgttgg agtggtgcca ggtactggtt ttggagaact tgtctacaac cagggattga     1500

ttttaaagat gtcttttttt attttacttt tttttaagca ccaaattttg ttgttttttt     1560

tttttctccc ctccccacag atcccatctc aaatcattct gttaaccacc attccaacag     1620

gtcgaggaga gcttaaacac cttcttcctc tgccttgttt ctcttttatt ttttattttt     1680

tcgcatcagt attaatgttt ttgcatactt tgcatcttta ttcaaaagtg taaactttct     1740

ttgtcaatct atggacatgc ccatatatga aggagatggg tgggtcaaaa agggatatca     1800

aatgaagtga taggggtcac aatggggaaa ttgaagtggt gcataacatt gccaaaatag     1860

tgtgccacta gaaatggtgt aaaggctgtc tttttttttt ttttttaaag aaaagttatt     1920

accatgtatt ttgtgaggca ggtttacaac actacaagtc ttgagttaag aaggaaagag     1980

gaaaaaagaa aaaacaccaa tacccagatt taaaaaaaaa aaaacgatca tagtcttagg     2040

agttcattta aaccatagga acttttcact tatctcatgt tagctgtacc agtcagtgat     2100

taagtagaac tacaagttgt ataggcttta ttgtttattg ctggtttatg accttaataa     2160

agtgtaatta tgtattacca gcagggtgtt tttaactgtg actattgtat aaaaacaaat     2220

cttgatatcc agaagcacat gaagtttgca actttccacc ctgcccattt ttgtaaaact     2280

gcagtcatct tggacctttt aaaacacaaa ttttaaactc aaccaagctg tgataagtgg     2340

aatggttact gtttatactg tggtatgttt ttgattacag cagataatgc tttcttttcc     2400

agtcgtcttt gagaataaag gaaaaaaaaa tcttcagatg caatggtttt gtgtagcatc     2460

ttgtctatca tgttttgtaa atactggaga agctttgacc aatttgactt agagatggaa     2520

tgtaactttg cttacaaaaa ttgctattaa actcctgctt aaggtgttct aattttctgt     2580

gagcacacta aaagcgaaaa ataaatgtga ataaaatgta caaatttgtt gtgttttttt     2640

atgttctaat aatactgaga cttctaggtc ttaggttaat ttttaggaag atcttgcatg     2700

ccatcaggag taaattttat tgtggttctt aatctgaagt tttcaagctc tgaaattcat     2760

aatccgcagt gtcagattac gtagaggaag atcttacaac attccatgtc aaatctgtta     2820

ccatttattg gcatttagtt ttcatttaag aattgaacat aattattttt attgtagcta     2880

tatagcatgt cagattaaat catttacaac aaaaggggtg tgaacctaag actatttaaa     2940

tgtcttatga gaaaatttca taaagccatt ctcttgtcat tcaggtccag aaacaaattt     3000

taaactgagt gagagtctat agaatccata ctgcagatgg gtcatgaaat gtgaccaaat     3060

gtgtttcaaa aattgatggt gtattacctg ctattgtaat tgcttagtgc ttggctaatt     3120

tccaaattat tgcataatat gttctacctt aagaaaacag gtttatgtaa caaagtaatg     3180

gtgttgaatg gatgatgtca gttcatgggc ctttagcata gttttaagca tcattttttt     3240

tttttttttt gaaagtgtgt tagcatcttg ttactcaaag gataagacag acaataatac     3300

ttcactgaat attaataatc tttactagtt tacctcctct gctctttgcc acccgataac     3360

tggatatctt ttccttcaaa ggaccctaaa ctgattgaaa tttaagatat gtatcaaaaa     3420

cattatttca tttaatgcac atctgttttg ctgtttttga gcagtgtgca gtttagggtt     3480

catgataaat cattgaacca catgtgtaac aactgaatgc caaatcttaa actcattaga     3540

aaaataacaa attaggtttt gacacgcatt cttaattgga ataatggatc aaaaatagtg     3600

gttcatgacc ttaccaaaca cccttgctac taataaaatc aaataacact tagaagggta     3660

tgtattttta gttagggttt cttgatcttg gaggatgttt gaaagttaaa aattgaattt     3720

ggtaaccaaa ggactgattt atgggtcttt cctatcttaa ccaacgtttt cttagttacc     3780

tagatggcca agtacagtgc ctggtatgta gtaagactca gtaaaaaagt ggatttttaa     3840

aaataactcc caaagtgaat agtcaaaaat cctgttagca aactgttata tattgctaag     3900

tttgttcttt taacagctgg aatttattaa gatgcattat tttgatttta ttcactgcct     3960

aaaacacttt gggtggtatt gatggagttg gtggattttc ctccaagtga ttaaatgaaa     4020

tttgacgtat cttttcatcc aaagttttgt acatcatgtt ttctaacgga aaaaaatgtt     4080

aatatggctt ttttgtatta ctaaaaatag ctttgagatt aaggaaaaat aaataactct     4140

tgtacagttc agtattgtct attaaatctg tattggcagt atgtataatg gcatttgctg     4200

tggttacaaa atacttcctc tgggttataa taatcatttg atccaattcc tattgcttgt     4260

aaaataaagt tttaccagtt gatataatca aaaaaaaaaa aaaa                      4304


<210>  310
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  310

Met Gly Ala Gln Phe Ser Lys Thr Ala Ala Lys Gly Glu Ala Ala Ala 
1               5                   10                  15      


Glu Arg Pro Gly Glu Ala Ala Val Ala Ser Ser Pro Ser Lys Ala Asn 
            20                  25                  30          


Gly Gln Glu Asn Gly His Val Lys Val Asn Gly Asp Ala Ser Pro Ala 
        35                  40                  45              


Ala Ala Glu Ser Gly Ala Lys Glu Glu Leu Gln Ala Asn Gly Ser Ala 
    50                  55                  60                  


Pro Ala Ala Asp Lys Glu Glu Pro Ala Ala Ala Gly Ser Gly Ala Ala 
65                  70                  75                  80  


Ser Pro Ser Ala Ala Glu Lys Gly Glu Pro Ala Ala Ala Ala Ala Pro 
                85                  90                  95      


Glu Ala Gly Ala Ser Pro Val Glu Lys Glu Ala Pro Ala Glu Gly Glu 
            100                 105                 110         


Ala Ala Glu Pro Gly Ser Pro Thr Ala Ala Glu Gly Glu Ala Ala Ser 
        115                 120                 125             


Ala Ala Ser Ser Thr Ser Ser Pro Lys Ala Glu Asp Gly Ala Thr Pro 
    130                 135                 140                 


Ser Pro Ser Asn Glu Thr Pro Lys Lys Lys Lys Lys Arg Phe Ser Phe 
145                 150                 155                 160 


Lys Lys Ser Phe Lys Leu Ser Gly Phe Ser Phe Lys Lys Asn Lys Lys 
                165                 170                 175     


Glu Ala Gly Glu Gly Gly Glu Ala Glu Ala Pro Ala Ala Glu Gly Gly 
            180                 185                 190         


Lys Asp Glu Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Glu Ala Gly 
        195                 200                 205             


Ala Ala Ser Gly Glu Gln Ala Ala Ala Pro Gly Glu Glu Ala Ala Ala 
    210                 215                 220                 


Gly Glu Glu Gly Ala Ala Gly Gly Asp Pro Gln Glu Ala Lys Pro Gln 
225                 230                 235                 240 


Glu Ala Ala Val Ala Pro Glu Lys Pro Pro Ala Ser Asp Glu Thr Lys 
                245                 250                 255     


Ala Ala Glu Glu Pro Ser Lys Val Glu Glu Lys Lys Ala Glu Glu Ala 
            260                 265                 270         


Gly Ala Ser Ala Ala Ala Cys Glu Ala Pro Ser Ala Ala Gly Pro Gly 
        275                 280                 285             


Ala Pro Pro Glu Gln Glu Ala Ala Pro Ala Glu Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Ala Cys Ala Ala Pro Ser Gln Glu Ala Gln Pro Glu 
305                 310                 315                 320 


Cys Ser Pro Glu Ala Pro Pro Ala Glu Ala Ala Glu 
                325                 330         


<210>  311
<211>  1866
<212>  DNA
<213>  Homo Sapiens

<400>  311
gcattgctac ctgcccttct caaagcccac atgttgtatt ttatgcaaat ctacagatta       60

tctatcatta tctaaatgca ggcatctgaa aaccagcagt aatcctgcct ctgaagttta      120

tcaggaaagg agcttaaaag agaaccaaat tcagcctgtg ttggaactct cagtcccaga      180

ggggtgtggt ttgtagctct ccggcctgct gttggactta ggctgtgacc cacagaagga      240

cgccagaaag tactcaagac attcacggtg ccccggtcag cactcgccat gacgaagact      300

tctacatgca tataccactt ccttgttctg agctggtata ctttcctcaa ttattacatc      360

tcacaggaag gaaaagacga ggtgaaaccc aaaatcttgg caaatggtgc aaggtggaaa      420

tatatgacgc tgcttaatct gctcaagaac aggactgctg ggtttgacat ctaccagcca      480

ggaagcttta ggcagctctt gcagaccatt ttctacgggg tcacctgcct ggatgatgtg      540

ctgaaaagaa ccaaaggggg aaaagacatt aagttcctaa ctgccttcag agacctgctt      600

ttcaccactc tggcttttcc tgtatccacg tttgtatttt tggcattctg gatcctcttt      660

ctctacaatc gagatctcat ttaccccaag gtcctagata ctgtcatccc cgtgtggctg      720

aatcatgcaa tgcacacttt catattcccc atcacattgg ctgaagtcgt cctcaggcct      780

cactcctatc catcaaagaa gacaggactc accttgctgg ctgctgccag cattgcttac      840

atcagccgca tcctatggct ctactttgag acgggtacct gggtgtatcc tgtgtttgcc      900

aaactcagcc tcttgggtct agcagctttc ttctctctca gctacgtctt catcgccagc      960

atctacctac ttggagagaa gctcaaccac tggaaatggg gtgacatgag gcagccacgg     1020

aagaagagga agtaattgca caccattttc caagaaccaa gaaagaagaa aacacaagag     1080

atttttctca tctttttttt ttttttctgg tggagggagg tggtggagga acatagcaaa     1140

gtaggaggga cagagagtga tacttaaatt taataagagg ttcgtgaagg tagcttaact     1200

tgagaactct tggttttttg aaaggttgac tgcacatgcc aaaaacaact cctgctatct     1260

cagaattaat tatctttgac cttcgtggag gatggtctct ggttaaaatc tggccaaaga     1320

aactcacata aacttggtgt tagagaacat ctagagagag agagaggaac ttagagtcat     1380

ttaaactctt cagtttacag agaaggatgc tgaggaccta gatgagaagt tacctgcaaa     1440

aggcaaaagg gttacttagt gtcagaacca aggcaatgac ttctctctcc cagatctcct     1500

agctactggt cctgggccat tttttttttt ttaaataatc ccaactttct ttaaaagaca     1560

agcatttcag taagctagtt attttcatgg gttgctcatc catttttttc agtgatctaa     1620

aaatgtaggg agatggctac tactgaagtt gtctgtctac ttgggataat agcaaattaa     1680

ttgaagacaa tgggaaagta agttataaaa aatactggga aatctgtttc tcttctgagc     1740

aagcattcag ggcaggtata aacatcaaac atagtgacat tgtcaaaacc tcttccattt     1800

gaacattgat taattcatca aataaatggt atagtaataa attttgcttg cagaagaaaa     1860

aaaaaa                                                                1866


<210>  312
<211>  248
<212>  PRT
<213>  Homo Sapiens

<400>  312

Met Thr Lys Thr Ser Thr Cys Ile Tyr His Phe Leu Val Leu Ser Trp 
1               5                   10                  15      


Tyr Thr Phe Leu Asn Tyr Tyr Ile Ser Gln Glu Gly Lys Asp Glu Val 
            20                  25                  30          


Lys Pro Lys Ile Leu Ala Asn Gly Ala Arg Trp Lys Tyr Met Thr Leu 
        35                  40                  45              


Leu Asn Leu Leu Lys Asn Arg Thr Ala Gly Phe Asp Ile Tyr Gln Pro 
    50                  55                  60                  


Gly Ser Phe Arg Gln Leu Leu Gln Thr Ile Phe Tyr Gly Val Thr Cys 
65                  70                  75                  80  


Leu Asp Asp Val Leu Lys Arg Thr Lys Gly Gly Lys Asp Ile Lys Phe 
                85                  90                  95      


Leu Thr Ala Phe Arg Asp Leu Leu Phe Thr Thr Leu Ala Phe Pro Val 
            100                 105                 110         


Ser Thr Phe Val Phe Leu Ala Phe Trp Ile Leu Phe Leu Tyr Asn Arg 
        115                 120                 125             


Asp Leu Ile Tyr Pro Lys Val Leu Asp Thr Val Ile Pro Val Trp Leu 
    130                 135                 140                 


Asn His Ala Met His Thr Phe Ile Phe Pro Ile Thr Leu Ala Glu Val 
145                 150                 155                 160 


Val Leu Arg Pro His Ser Tyr Pro Ser Lys Lys Thr Gly Leu Thr Leu 
                165                 170                 175     


Leu Ala Ala Ala Ser Ile Ala Tyr Ile Ser Arg Ile Leu Trp Leu Tyr 
            180                 185                 190         


Phe Glu Thr Gly Thr Trp Val Tyr Pro Val Phe Ala Lys Leu Ser Leu 
        195                 200                 205             


Leu Gly Leu Ala Ala Phe Phe Ser Leu Ser Tyr Val Phe Ile Ala Ser 
    210                 215                 220                 


Ile Tyr Leu Leu Gly Glu Lys Leu Asn His Trp Lys Trp Gly Asp Met 
225                 230                 235                 240 


Arg Gln Pro Arg Lys Lys Arg Lys 
                245             


<210>  313
<211>  6531
<212>  DNA
<213>  Homo Sapiens

<400>  313
gcccagccag cttgcgtcac cgcttcagag cggagaagag cgagcagggg agagcgagac       60

cagttttaag gggaggaccg gtgcgagtga ggcagccccg aggctctgct cgcccaccac      120

ccaatcctcg cctcccttct gctccacctt ctctctctgc cctcacctct cccccgaaaa      180

ccccctattt agccaaagga aggaggtcag gggaacgctc tcccctcccc ttccaaaaaa      240

caaaaacaga aaaacccttt tccaggccgg ggaaagcagg agggagaggg gccgccgggc      300

tggccatgga gctgctgtgc cacgaggtgg acccggtccg cagggccgtg cgggaccgca      360

acctgctccg agacgaccgc gtcctgcaga acctgctcac catcgaggag cgctaccttc      420

cgcagtgctc ctacttcaag tgcgtgcaga aggacatcca accctacatg cgcagaatgg      480

tggccacctg gatgctggag gtctgtgagg aacagaagtg cgaagaagag gtcttccctc      540

tggccatgaa ttacctggac cgtttcttgg ctggggtccc gactccgaag tcccatctgc      600

aactcctggg tgctgtctgc atgttcctgg cctccaaact caaagagacc agcccgctga      660

ccgcggagaa gctgtgcatt tacaccgaca actccatcaa gcctcaggag ctgctggagt      720

gggaactggt ggtgctgggg aagttgaagt ggaacctggc agctgtcact cctcatgact      780

tcattgagca catcttgcgc aagctgcccc agcagcggga gaagctgtct ctgatccgca      840

agcatgctca gaccttcatt gctctgtgtg ccaccgactt taagtttgcc atgtacccac      900

cgtcgatgat cgcaactgga agtgtgggag cagccatctg tgggctccag caggatgagg      960

aagtgagctc gctcacttgt gatgccctga ctgagctgct ggctaagatc accaacacag     1020

acgtggattg tctcaaagct tgccaggagc agattgaggc ggtgctcctc aatagcctgc     1080

agcagtaccg tcaggaccaa cgtgacggat ccaagtcgga ggatgaactg gaccaagcca     1140

gcacccctac agacgtgcgg gatatcgacc tgtgaggatg ccagttgggc cgaaagagag     1200

agacgcgtcc ataatctggt ctcttcttct ttctggttgt ttttgttctt tgtgttttag     1260

ggtgaaactt aaaaaaaaaa ttctgccccc acctagatca tatttaaaga tcttttagaa     1320

gtgagagaaa aaggtcctac gaaaacggaa taataaaaag catttggtgc ctatttgaag     1380

tacagcataa gggaatccct tgtatatgcg aacagttatt gtttgattat gtaaaagtaa     1440

tagtaaaatg cttacaggaa aacctgcaga gtagttagag aatatgtatg cctgcaatat     1500

gggaacaaat tagaggagac tttttttttt catgttatga gctagcacat acaccccctt     1560

gtagtataat ttcaaggaac tgtgtacgcc atttatggca tgattagatt gcaaagcaat     1620

gaactcaaga aggaattgaa ataaggaggg acatgatggg gaaggagtac aaaacaatct     1680

ctcaacatga ttgaaccatt tgggatggag aagcaccttt gctctcagcc acctgttact     1740

aagtcaggag tgtagttgga tctctacatt aatgtcctct tgctgtctac agtagctgct     1800

acctaaaaaa agatgtttta ttttgccagt tggacacagg tgattggctc ctgggtttca     1860

tgttctgtga catcctgctt cttcttccaa atgcagttca ttgcagacac caccatattg     1920

ctatctaatg gggaaatgta gctatgggcc ataaccaaaa ctcacatgaa acggaggcag     1980

atggagacca agggtgggat ccagaatgga gtcttttctg ttattgtatt taaaagggta     2040

atgtggcctt ggcatttctt cttagaaaaa aactaatttt tggtgctgat tggcatgtct     2100

ggttcacagt ttagcattgt tataaaccat tccattcgaa aagcactttg aaaaattgtt     2160

cccgagcgat agatgggatg gtttatgcaa gtcatgctga atactcctcc cctcttctct     2220

tttgccccct cccttcctgc ccccagtctg ggttactctt cgcttctggt atctggcgtt     2280

ctttggtaca cagttctggt gttcctacca ggactcaaga gacacccctt cctgctgaca     2340

ttcccatcac aacattcctc agacaagcct gtaaactaaa atctgttacc attctgatgg     2400

cacagaagga tcttaattcc catctctata cttctccttt ggacatggaa agaaaagtta     2460

ttgctggtgc aaagatagat ggctgaacat cagggtgtgg cattttgttc ccttttccgt     2520

tttttttttt ttattgttgt tgttaatttt attgcaaagt tgtattcagc gtacttgaat     2580

ttttcttcct ctccacttct tagaggcatt cagttagcaa agaggttgga gcaacaactt     2640

tttttttttt ttttgcacaa ttgtaattga caggtaatga agctatttgt taaaatattt     2700

gcctttttaa gtaaaaaaga aaaatcagaa cagggctatt tgaagaatta ttttatacac     2760

agattctgcc ttgtttcata gtatgagggt tgaagacgga aaacaatcta agggtctctc     2820

atttttttaa ttttgttttg ttcagtttgg tttttttttt tttttgcgct gctaagaagc     2880

taaagtcatc catccttatt cacgttgaca gtacctagct gtaatgtttc acagagtgtg     2940

ctgctatttt ataaacattt ttataatata ttattttact gcttaaattc caagtcctga     3000

agtagatggt tgagatatga gttcttcgta ctggaaaagc ccttccgtag tttgttttct     3060

tctggtagca tattcatggt tgtttttttt tttctttttt ggttttttgg tttttttttt     3120

ttcctctgat cacattcttc aaagacggag tattctttac ctcaggttta ctggacaaaa     3180

tcaataacta caaaaggcaa tgattcacgc ttttgttttc ataatacctc acaaccgtac     3240

agtttctgct tgggagccca ttcgcatgag gaatacagaa gcagtgtgag cagggctgac     3300

tccctctcag gtggaaggca gggcggtctc actcccaggg acctttttgg tcatggaggc     3360

catcgggctc ccagttagac cctggtatcc tcatcatgat ggaaaaaata cattgaacca     3420

agggatcctc cctccccttc aaggcagacg ttcagtacaa acatttatgc ggtaggctca     3480

gatgtcgtaa tttgcactta ggtaccaggt gtcaggaaac agactaaaaa gaattccacc     3540

aggctgtttg gagatcctca tcttggagct ttttcaaaag cggggcttca tctgcaaagg     3600

gccctttcat cttgaagttt ttcccctccg tctttcccct cccctggcat ggacaccttg     3660

tgtttaggat catctctgca ggtttcctag gtctgaatct gcgagtagat gaacctgcag     3720

caagcagcgt ttatggtgct tccttctccc tcctctgtct caaactgcgc aggcaagcac     3780

tatgcaagcc caggccctct gctgagcggt actaaacggt cgggttttca atcacactga     3840

attggcagga taagaaaaat aggtcagata agtatgggat gatagttgaa gggaggtgaa     3900

gaggctgctt ctctacagag gtgaaattcc agatgagtca gtctcttggg aagtgtgttt     3960

agaagggttc aggactttgt gagttagcat gaccctaaaa ttctagggga tttctggtgg     4020

gacaatgggt ggtgaattct gaagttttgg agagggaagt ggagcagcca gcaagtaagc     4080

tagccagagt tttctcaaga gccagctttg ctcagcacac tctcctgggc cccaaggagt     4140

cccacggaat ggggaaagcg ggaaccctgg agttcttggg aatcttggag cctaaagaga     4200

aaccgaggtg caaattcatt tcatggtgac tgacccttga gcttaaacag aagcagcaaa     4260

tgaaagaacc ggacaaataa ggaagggcac aagcctaccc gactctattt acagtctgta     4320

actttccact cttcctgtag tcccgaggcc cctgggtcct tctagctttt ctctttccca     4380

tccttggggc cttgtgtgat gatgggtgtg gggctgccga tgggaaagtc gggggttgtt     4440

aggcttttct gcctgctcct gcttaaacac aagaaggaat cctggatttt gccctctcct     4500

tagctcttag tctctttggt aggagttttg ttccagagga gctctccccc ttggatttga     4560

acttgctctt tttgttgttg ttgttctttc tcttcttttt cttacctccc actaaagggg     4620

ttccaaatta tcctggtctt tttctacctt gttgtgtttc tatctcgtct ttacttccat     4680

ctgtttgttt ttttctccat cagtgggggc cgagttgttc ccccagcctg ccaaattttg     4740

atccttcccc tcttttggcc aaatcctagg gggaagaaat cctagtatgc caaaaatata     4800

tgctaagcat aattaaactc catgcgggtc cataacagcc aagaagcctg caggagaaag     4860

ccaagggcag ttccctccgc agaacacccc atgcgtgctg agaggcgagc tccttgaaga     4920

aggggctgtt cttccaggag gccttatttt gaactgcctc aggaccccac tggagagcac     4980

agcatgcctt actactgggt catccttggt ctatgtgctc tgtactggag gctctgttct     5040

gcctcttatc agccaggtca ggggcacaca tggcttaagt gacaaagcca gaggagaaga     5100

caaccctgac agcatcacgc tgcatcccat tgctagcagg attggcaact cttcagacgg     5160

agctgcgctt ccctgcagtc tagcacctct agggcctctc cagactgtgc cctgggagct     5220

ctgggactga aaggttaaga acataaggca ggatcagatg actctctcca agagggcagg     5280

ggaattttct ctccatgggc cacaggggac agggctggga gaagaaatag acttgcacct     5340

tatgtcatgt aaataattga ttttctagtt caagaagata atattggtag tgtgggaatt     5400

ggaggtagga aggggaggaa gtctgagtaa gccagttggc ttctaagcca aaaggattcc     5460

tctttgttta tctctgagac agtccaacct tgagaatagc tttaaaaggg aaattaatgc     5520

tgagatgata aagtcccctt aagccaacaa accctctgta gctatagaat gagtgcaggt     5580

ttctattggt gtggactcag agcaatttac aagagctgtt catgcagcca tccatttgtg     5640

caaaataggg taagaagatt caagaggata tttattactt cctcatacca catggctttt     5700

gatgattctg gattctaaac aacccagaat ggtcatttca ggcacaacga tactacattc     5760

gtgtgtgtct gcttttaaac ttggctgggc tatcagaccc tattctcggc tcaggttttg     5820

agaagccatc agcaaatgtg tacgtgcatg ctgtagctgc agcctgcatc ccttcgcctg     5880

cagcctactt tggggaaata aagtgcctta ctgactgtag ccattacagt atccaatgtc     5940

ttttgacagg tgcctgtcct tgaaaaacaa agtttctatt tttattttta attggtttag     6000

ttcttaactg ctggccaact cttacatccc cagcaaatca tcgggccatt ggattttttc     6060

cattatgttc atcaccctta tatcatgtac ctcagatctc tctctctctc ctctctctca     6120

gttatgtagt ttcttgtctt ggactttttt ttttcttttc tttttctttt tttttttgct     6180

ttaaaacaag tgtgatgcca tatcaagtcc atgttattct ctcacagtgt actctataag     6240

aggtgtgggt gtctgtttgg tcaggatgtt agaaagtgct gataagtagc atgatcagtg     6300

tatgcgaaaa ggtttttagg aagtatggca aaaatgttgt attggctatg atggtgacat     6360

gatatagtca gctgcctttt aagaggtctt atctgttcag tgttaagtga tttaaaaaaa     6420

taataacctg ttttctgact agtttaaaga tggatttgaa aatggttttg aatgcaatta     6480

ggttatgcta tttggacaat aaactcacct tgacctaaat taaaaaaaaa a              6531


<210>  314
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  314

Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg 
1               5                   10                  15      


Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 
            20                  25                  30          


Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 
        35                  40                  45              


Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu 
    50                  55                  60                  


Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala 
65                  70                  75                  80  


Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser 
                85                  90                  95      


His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu 
            100                 105                 110         


Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp 
        115                 120                 125             


Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu 
    130                 135                 140                 


Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile 
145                 150                 155                 160 


Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 
                165                 170                 175     


Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe 
            180                 185                 190         


Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly 
        195                 200                 205             


Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr 
    210                 215                 220                 


Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val 
225                 230                 235                 240 


Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn 
                245                 250                 255     


Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu 
            260                 265                 270         


Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 
        275                 280                 285             


Leu 
    


<210>  315
<211>  3296
<212>  DNA
<213>  Homo Sapiens

<400>  315
ccggcaccga caagtgcgct gcaccagtgg caccggctgg gggcgagccg acctcgagca       60

gccgccgccg ccgccgtcgt tgctactgcc gcagcggagt tcagagggcc cggaggtggg      120

agacttccca cacggtgact gagatgtcgt ccactgcggc tttttacctt ctctctacgc      180

taggaggata cttggtgacc tcattcttgt tgcttaaata cccgaccttg ctgcaccaga      240

gaaagaagca gcgattcctc agtaaacaca tctctcaccg cggaggtgct ggagaaaatt      300

tggagaatac aatggcagcc tttcagcatg cggttaaaat cggaactgat atgctagaat      360

tggactgcca tatcacaaaa gatgaacaag ttgtagtgtc acatgatgag aatctaaaga      420

gagcaactgg ggtcaatgta aacatctctg atctcaaata ctgtgagctc ccaccttacc      480

ttggcaaact ggatgtctca tttcaaagag catgccagtg tgaaggaaaa gataaccgaa      540

ttccattact gaaggaagtt tttgaggcct ttcctaacac tcccattaac atcgatatca      600

aagtcaacaa caatgtgctg attaagaagg tttcagagtt ggtgaagcgg tataatcgag      660

aacacttaac agtgtggggt aatgccaatt atgaaattgt agaaaagtgc tacaaagaga      720

attcagatat tcctatactc ttcagtctac aacgtgtcct gctcattctt ggccttttct      780

tcactggcct cttgcccttt gtgcccattc gagaacagtt ttttgaaatc ccaatgcctt      840

ctattatact gaagctaaaa gaaccacaca ccatgtccag aagtcaaaag tttctcatct      900

ggctttctga tctcttacta atgaggaaag ctttgtttga ccacctaact gctcgaggca      960

ttcaagtgta tatttgggta ttaaatgaag aacaagaata caaaagagct tttgatttgg     1020

gagcaactgg ggtgatgaca gactatccaa caaagcttag ggatttttta cataactttt     1080

cagcatagaa aaagaggtac ttagaagtat tgaaggaaaa aatgaagacc taagaaaaaa     1140

atatttcatg atcatttccc taagccattt ccagaatggt aaaaggttta atcagttttt     1200

attacctcat ttttaagcct gtatgagaat gtagaaacta tatattatat gtatatttat     1260

tttaaataat attgtatatt ttatgtttgt aaattgttta gaaagataat tggttatgag     1320

atgtaagttt taatttctta atgtgcattt ttgtttctag atcttataca gaaatcttga     1380

ttaataacat acacagaaat gtacatacta catcatctac agaaatcttg atcaataacc     1440

tagaaactag gttatctagg ttattgatca agatttctgt agatgatgca gtgttctatc     1500

ataagtaatt ctggaatcaa agactattgg atacatttgg cattgggctg agtgtggtgg     1560

ctcatgcctg taatcccagc actttgggag gctgagacag gcggatcatc tgaagtcagg     1620

agttaaagac cagcctggcc aacatggcaa aaccccatct ctaccaaaaa tacaaaaatt     1680

aaccatgcgt ggtggtacac gtctgtcatc ccagcagctc ttaaggctga ggcacaagaa     1740

ttgcttgaac ccgggaggca gaggctgtag tgagccaaga tagcaccact gcactccagc     1800

ctgggagaca gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaaaaaa atgggaggcc     1860

gaggcgggcg gatcacgagg tcaggagatc gagaccatcc tggctaacat ggtgaaaccc     1920

cgtctctact aaaaatacaa aaaattagct gggcgtggtg gtgggcacct tagtcccagc     1980

tactcgggag gctgagtcag gagaatggcg tgaacccggg aggcggagct tgcagtgagc     2040

cgagatcgcg ccactgcact ccagcctggg ctacagagca agactccgtc tcaaaaaaag     2100

aaaaaaagaa aaaaaattgg caatagtctt cactggaata caatcaatta gtaaaagatt     2160

tttttttttt ttttgacatg tagtcttgct ctgtcgccga ggccggagtg cagtggtgcg     2220

atcttggctc actgcaacct ctgcctccca ggttccagca attctcctgc ctctgcctcc     2280

cgagtacctg ggattacagg tgcctgctac catgcccagc taatttttgt atttttagta     2340

gagacagggt tttgccacgt tggccagact ggtctcgaac tcctgacctc aggtgatcca     2400

cccacctcgg cctctcaaag tgctgggatt acaggtttga accactgcac ccggccagta     2460

aaagaaattt tgaaggccat tgcagctatt tggtagtgtc ttgttatttc taggtgtacc     2520

ttagttaaag aggaaaaata aaacggaaaa aagcttggaa atcagtgatg tgtagttatt     2580

tggcaagtta tacataatca gcagcagcca ggctcaagaa aataaaagtt gattagttga     2640

tcagaaataa aatctgtaga gtgaattaga tttctgagtt gttgttgtta atggaacatt     2700

ctatttgaga cctttttcag gtgtgtagca attctaccat gtccattttt ttaagcatta     2760

aaaaggaact taccagttgt aaattaagac aagatccaaa tagtcatatt tttgtgtttc     2820

ctctaaaaaa atgtaagatt tccatttttg gcactgacta actgagccta catctagatt     2880

ttaaatacca tcttgaatcc taataattaa actgatgaaa gtgcatatca ttgttcctaa     2940

catttatgaa cccccataaa gatgttcctg atctttaaaa ctcattaatc tgagtattaa     3000

gtagaaacag aattttccaa agcattagac atcactttct cagtttatct gaggtgactt     3060

cgtgtacatc tgtttctaat atatttgact aattttcatg atctcagatt gtgaggtaaa     3120

tgtaatctgg aataataagt gtcttttacc tagattacat ctctcatttg gagtttggca     3180

atgaaactgc tatgaagaat gactgtactc tcctatctgt ccctggatga cataaatatc     3240

atttgctttg ttgtttaaac tgaaataaag ttttccaaga acaaaaaaaa aaaaaa         3296


<210>  316
<211>  314
<212>  PRT
<213>  Homo Sapiens

<400>  316

Met Ser Ser Thr Ala Ala Phe Tyr Leu Leu Ser Thr Leu Gly Gly Tyr 
1               5                   10                  15      


Leu Val Thr Ser Phe Leu Leu Leu Lys Tyr Pro Thr Leu Leu His Gln 
            20                  25                  30          


Arg Lys Lys Gln Arg Phe Leu Ser Lys His Ile Ser His Arg Gly Gly 
        35                  40                  45              


Ala Gly Glu Asn Leu Glu Asn Thr Met Ala Ala Phe Gln His Ala Val 
    50                  55                  60                  


Lys Ile Gly Thr Asp Met Leu Glu Leu Asp Cys His Ile Thr Lys Asp 
65                  70                  75                  80  


Glu Gln Val Val Val Ser His Asp Glu Asn Leu Lys Arg Ala Thr Gly 
                85                  90                  95      


Val Asn Val Asn Ile Ser Asp Leu Lys Tyr Cys Glu Leu Pro Pro Tyr 
            100                 105                 110         


Leu Gly Lys Leu Asp Val Ser Phe Gln Arg Ala Cys Gln Cys Glu Gly 
        115                 120                 125             


Lys Asp Asn Arg Ile Pro Leu Leu Lys Glu Val Phe Glu Ala Phe Pro 
    130                 135                 140                 


Asn Thr Pro Ile Asn Ile Asp Ile Lys Val Asn Asn Asn Val Leu Ile 
145                 150                 155                 160 


Lys Lys Val Ser Glu Leu Val Lys Arg Tyr Asn Arg Glu His Leu Thr 
                165                 170                 175     


Val Trp Gly Asn Ala Asn Tyr Glu Ile Val Glu Lys Cys Tyr Lys Glu 
            180                 185                 190         


Asn Ser Asp Ile Pro Ile Leu Phe Ser Leu Gln Arg Val Leu Leu Ile 
        195                 200                 205             


Leu Gly Leu Phe Phe Thr Gly Leu Leu Pro Phe Val Pro Ile Arg Glu 
    210                 215                 220                 


Gln Phe Phe Glu Ile Pro Met Pro Ser Ile Ile Leu Lys Leu Lys Glu 
225                 230                 235                 240 


Pro His Thr Met Ser Arg Ser Gln Lys Phe Leu Ile Trp Leu Ser Asp 
                245                 250                 255     


Leu Leu Leu Met Arg Lys Ala Leu Phe Asp His Leu Thr Ala Arg Gly 
            260                 265                 270         


Ile Gln Val Tyr Ile Trp Val Leu Asn Glu Glu Gln Glu Tyr Lys Arg 
        275                 280                 285             


Ala Phe Asp Leu Gly Ala Thr Gly Val Met Thr Asp Tyr Pro Thr Lys 
    290                 295                 300                 


Leu Arg Asp Phe Leu His Asn Phe Ser Ala 
305                 310                 


<210>  317
<211>  1494
<212>  DNA
<213>  Homo Sapiens

<400>  317
agtgaaacag aaggggaggt gcagtttcag aacccagcca gcctctctct tgctgcctag       60

cctcctgccg gcctcatctt cgcccagcca accccgcctg gagccctatg gccaactgcg      120

agttcagccc ggtgtccggg gacaaaccct gctgccggct ctctaggaga gcccaactct      180

gtcttggcgt cagtatcctg gtcctgatcc tcgtcgtggt gctcgcggtg gtcgtcccga      240

ggtggcgcca gcagtggagc ggtccgggca ccaccaagcg ctttcccgag accgtcctgg      300

cgcgatgcgt caagtacact gaaattcatc ctgagatgag acatgtagac tgccaaagtg      360

tatgggatgc tttcaagggt gcatttattt caaaacatcc ttgcaacatt actgaagaag      420

actatcagcc actaatgaag ttgggaactc agaccgtacc ttgcaacaag attcttcttt      480

ggagcagaat aaaagatctg gcccatcagt tcacacaggt ccagcgggac atgttcaccc      540

tggaggacac gctgctaggc taccttgctg atgacctcac atggtgtggt gaattcaaca      600

cttccaaaat aaactatcaa tcttgcccag actggagaaa ggactgcagc aacaaccctg      660

tttcagtatt ctggaaaacg gtttcccgca ggtttgcaga agctgcctgt gatgtggtcc      720

atgtgatgct caatggatcc cgcagtaaaa tctttgacaa aaacagcact tttgggagtg      780

tggaagtcca taatttgcaa ccagagaagg ttcagacact agaggcctgg gtgatacatg      840

gtggaagaga agattccaga gacttatgcc aggatcccac cataaaagag ctggaatcga      900

ttataagcaa aaggaatatt caattttcct gcaagaatat ctacagacct gacaagtttc      960

ttcagtgtgt gaaaaatcct gaggattcat cttgcacatc tgagatctga gccagtcgct     1020

gtggttgttt tagctccttg actccttgtg gtttatgtca tcatacatga ctcagcatac     1080

ctgctggtgc agagctgaag attttggagg gtcctccaca ataaggtcaa tgccagagac     1140

ggaagccttt ttccccaaag tcttaaaata acttatatca tcagcatacc tttattgtga     1200

tctatcaata gtcaagaaaa attattgtat aagattagaa tgaaaattgt atgttaagtt     1260

acttcacttt aattctcatg tgatcctttt atgttattta tatattggta acatcctttc     1320

tattgaaaaa tcaccacacc aaacctctct tattagaaca ggcaagtgaa gaaaagtgaa     1380

tgctcaagtt tttcagaaag cattacattt ccaaatgaat gaccttgttg catgatgtat     1440

ttttgtaccc ttcctacaga tagtcaaacc ataaacttca tggtcatggg taaa           1494


<210>  318
<211>  300
<212>  PRT
<213>  Homo Sapiens

<400>  318

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  319
<211>  5966
<212>  DNA
<213>  Homo Sapiens

<400>  319
gtgatgttat ctgctggcag cagaaggttc gctccgagcg gagctccaga agctcctgac       60

aagagaaaga cagattgaga tagagataga aagagaaaga gagaaagaga cagcagagcg      120

agagcgcaag tgaaagaggc aggggagggg gatggagaat attagcctga cggtctaggg      180

agtcatccag gaacaaactg aggggctgcc cggctgcaga caggaggaga cagagaggat      240

ctattttagg gtggcaagtg cctacctacc ctaagcgagc aattccacgt tggggagaag      300

ccagcagagg ttgggaaagg gtgggagtcc aagggagccc ctgcgcaacc ccctcaggaa      360

taaaactccc cagccagggt gtcgcaaggg ctgccgttgt gatccgcagg gggtgaacgc      420

aaccgcgacg gctgatcgtc tgtggctggg ttggcgtttg gagcaagaga aggaggagca      480

ggagaaggag ggagctggag gctggaagcg tttgcaagcg gcggcggcag caacgtggag      540

taaccaagcg ggtcagcgcg cgcccgccag ggtgtaggcc acggagcgca gctcccagag      600

caggatccgc gccgcctcag cagcctctgc ggcccctgcg gcacccgacc gagtaccgag      660

cgccctgcga agcgcaccct cctccccgcg gtgcgctggg ctcgccccca gcgcgcgcac      720

acgcacacac acacacacac acacacacgc acgcacacac gtgtgcgctt ctctgctccg      780

gagctgctgc tgctcctgct ctcagcgccg cagtggaagg caggaccgaa ccgctccttc      840

tttaaatata taaatttcag cccaggtcag cctcggcggc ccccctcacc gcgctcccgg      900

cgcccctccc gtcagttcgc cagctgccag ccccgggacc ttttcatctc ttcccttttg      960

gccggaggag ccgagttcag atccgccact ccgcacccga gactgacaca ctgaactcca     1020

cttcctcctc ttaaatttat ttctacttaa tagccactcg tctctttttt tccccatctc     1080

attgctccaa gaattttttt cttcttactc gccaaagtca gggttccctc tgcccgtccc     1140

gtattaatat ttccactttt ggaactactg gccttttctt tttaaaggaa ttcaagcagg     1200

atacgttttt ctgttgggca ttgactagat tgtttgcaaa agtttcgcat caaaaacaac     1260

aacaacaaaa aaccaaacaa ctctccttga tctatacttt gagaattgtt gatttctttt     1320

ttttattctg acttttaaaa acaacttttt tttccacttt tttaaaaaat gcactactgt     1380

gtgctgagcg cttttctgat cctgcatctg gtcacggtcg cgctcagcct gtctacctgc     1440

agcacactcg atatggacca gttcatgcgc aagaggatcg aggcgatccg cgggcagatc     1500

ctgagcaagc tgaagctcac cagtccccca gaagactatc ctgagcccga ggaagtcccc     1560

ccggaggtga tttccatcta caacagcacc agggacttgc tccaggagaa ggcgagccgg     1620

agggcggccg cctgcgagcg cgagaggagc gacgaagagt actacgccaa ggaggtttac     1680

aaaatagaca tgccgccctt cttcccctcc gaaactgtct gcccagttgt tacaacaccc     1740

tctggctcag tgggcagctt gtgctccaga cagtcccagg tgctctgtgg gtaccttgat     1800

gccatcccgc ccactttcta cagaccctac ttcagaattg ttcgatttga cgtctcagca     1860

atggagaaga atgcttccaa tttggtgaaa gcagagttca gagtctttcg tttgcagaac     1920

ccaaaagcca gagtgcctga acaacggatt gagctatatc agattctcaa gtccaaagat     1980

ttaacatctc caacccagcg ctacatcgac agcaaagttg tgaaaacaag agcagaaggc     2040

gaatggctct ccttcgatgt aactgatgct gttcatgaat ggcttcacca taaagacagg     2100

aacctgggat ttaaaataag cttacactgt ccctgctgca cttttgtacc atctaataat     2160

tacatcatcc caaataaaag tgaagaacta gaagcaagat ttgcaggtat tgatggcacc     2220

tccacatata ccagtggtga tcagaaaact ataaagtcca ctaggaaaaa aaacagtggg     2280

aagaccccac atctcctgct aatgttattg ccctcctaca gacttgagtc acaacagacc     2340

aaccggcgga agaagcgtgc tttggatgcg gcctattgct ttagaaatgt gcaggataat     2400

tgctgcctac gtccacttta cattgatttc aagagggatc tagggtggaa atggatacac     2460

gaacccaaag ggtacaatgc caacttctgt gctggagcat gcccgtattt atggagttca     2520

gacactcagc acagcagggt cctgagctta tataatacca taaatccaga agcatctgct     2580

tctccttgct gcgtgtccca agatttagaa cctctaacca ttctctacta cattggcaaa     2640

acacccaaga ttgaacagct ttctaatatg attgtaaagt cttgcaaatg cagctaaaat     2700

tcttggaaaa gtggcaagac caaaatgaca atgatgatga taatgatgat gacgacgaca     2760

acgatgatgc ttgtaacaag aaaacataag agagccttgg ttcatcagtg ttaaaaaatt     2820

tttgaaaagg cggtactagt tcagacactt tggaagtttg tgttctgttt gttaaaactg     2880

gcatctgaca caaaaaaagt tgaaggcctt attctacatt tcacctactt tgtaagtgag     2940

agagacaaga agcaaatttt ttttaaagaa aaaaataaac actggaagaa tttattagtg     3000

ttaattatgt gaacaacgac aacaacaaca acaacaacaa acaggaaaat cccattaagt     3060

ggagttgctg tacgtaccgt tcctatcccg cgcctcactt gatttttctg tattgctatg     3120

caataggcac ccttcccatt cttactctta gagttaacag tgagttattt attgtgtgtt     3180

actatataat gaacgtttca ttgcccttgg aaaataaaac aggtgtataa agtggagacc     3240

aaatactttg ccagaaactc atggatggct taaggaactt gaactcaaac gagccagaaa     3300

aaaagaggtc atattaatgg gatgaaaacc caagtgagtt attatatgac cgagaaagtc     3360

tgcattaaga taaagaccct gaaaacacat gttatgtatc agctgcctaa ggaagcttct     3420

tgtaaggtcc aaaaactaaa aagactgtta ataaaagaaa ctttcagtca gaataagtct     3480

gtaagttttt ttttttcttt ttaattgtaa atggttcttt gtcagtttag taaaccagtg     3540

aaatgttgaa atgttttgac atgtactggt caaacttcag accttaaaat attgctgtat     3600

agctatgcta taggtttttt cctttgtttt ggtatatgta accataccta tattattaaa     3660

atagatggat atagaagcca gcataattga aaacacatct gcagatctct tttgcaaact     3720

attaaatcaa aacattaact actttatgtg taatgtgtaa atttttacca tattttttat     3780

attctgtaat aatgtcaact atgatttaga ttgacttaaa tttgggctct ttttaatgat     3840

cactcacaaa tgtatgtttc ttttagctgg ccagtacttt tgagtaaagc ccctatagtt     3900

tgacttgcac tacaaatgca tttttttttt aataacattt gccctacttg tgctttgtgt     3960

ttctttcatt attatgacat aagctacctg ggtccacttg tcttttcttt tttttgtttc     4020

acagaaaaga tgggttcgag ttcagtggtc ttcatcttcc aagcatcatt actaaccaag     4080

tcagacgtta acaaattttt atgttaggaa aaggaggaat gttatagata catagaaaat     4140

tgaagtaaaa tgttttcatt ttagcaagga tttagggttc taactaaaac tcagaatctt     4200

tattgagtta agaaaagttt ctctaccttg gtttaatcaa tatttttgta aaatcctatt     4260

gttattacaa agaggacact tcataggaaa catctttttc tttagtcagg tttttaatat     4320

tcagggggaa attgaaagat atatatttta gtcgattttt caaaagggga aaaaagtcca     4380

ggtcagcata agtcattttg tgtatttcac tgaagttata aggtttttat aaatgttctt     4440

tgaaggggaa aaggcacaag ccaatttttc ctatgatcaa aaaattcttt ctttcctctg     4500

agtgagagtt atctatatct gaggctaaag tttaccttgc tttaataaat aatttgccac     4560

atcattgcag aagaggtatc ctcatgctgg ggttaataga atatgtcagt ttatcacttg     4620

tcgcttattt agctttaaaa taaaaattaa taggcaaagc aatggaatat ttgcagtttc     4680

acctaaagag cagcataagg aggcgggaat ccaaagtgaa gttgtttgat atggtctact     4740

tcttttttgg aatttcctga ccattaatta aagaattgga tttgcaagtt tgaaaactgg     4800

aaaagcaaga gatgggatgc cataatagta aacagccctt gtgttggatg taacccaatc     4860

ccagatttga gtgtgtgttg attatttttt tgtcttccac ttttctatta tgtgtaaatc     4920

acttttattt ctgcagacat tttcctctca gataggatga cattttgttt tgtattattt     4980

tgtctttcct catgaatgca ctgataatat tttaaatgct ctattttaag atctcttgaa     5040

tctgtttttt ttttttttaa tttgggggtt ctgtaaggtc tttatttccc ataagtaaat     5100

attgccatgg gaggggggtg gaggtggcaa ggaaggggtg aagtgctagt atgcaagtgg     5160

gcagcaatta tttttgtgtt aatcagcagt acaatttgat cgttggcatg gttaaaaaat     5220

ggaatataag attagctgtt ttgtattttg atgaccaatt acgctgtatt ttaacacgat     5280

gtatgtctgt ttttgtggtg ctctagtggt aaataaatta tttcgatgat atgtggatgt     5340

ctttttccta tcagtaccat catcgagtct agaaaacacc tgtgatgcaa taagactatc     5400

tcaagctgga aaagtcatac cacctttccg attgccctct gtgctttctc ccttaaggac     5460

agtcacttca gaagtcatgc tttaaagcac aagagtcagg ccatatccat caaggataga     5520

agaaatccct gtgccgtctt tttattccct tatttattgc tatttggtaa ttgtttgaga     5580

tttagtttcc atccagcttg actgccgacc agaaaaaatg cagagagatg tttgcaccat     5640

gctttggctt tctggttcta tgttctgcca acgccagggc caaaagaact ggtctagaca     5700

gtatcccctg tagccccata acttggatag ttgctgagcc agccagatat aacaagagcc     5760

acgtgctttc tggggttggt tgtttgggat cagctacttg cctgtcagtt tcactggtac     5820

cactgcacca caaacaaaaa aacccaccct atttcctcca atttttttgg ctgctaccta     5880

caagaccaga ctcctcaaac gagttgccaa tctcttaata aataggatta ataaaaaaag     5940

taattgtgac tcaaaaaaaa aaaaaa                                          5966


<210>  320
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  320

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                 120                 125             


Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                 135                 140                 


Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                 150                 155                 160 


Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                 170                 175     


Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                 185                 190         


Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                 200                 205             


Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                 215                 220                 


Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                 230                 235                 240 


His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                 250                 255     


Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                 265                 270         


Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                 280                 285             


Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                 295                 300                 


Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                 310                 315                 320 


Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                 330                 335     


Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                 345                 350         


Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                 360                 365             


Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                 375                 380                 


Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                 390                 395                 400 


Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                 410                 415     


Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                 425                 430         


Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                 440         


<210>  321
<211>  4074
<212>  DNA
<213>  Homo Sapiens

<400>  321
gacaggcctc tcggcgagcc ggtgccccat cgggtaccgc acggctgccg cggcggcctt       60

accctgccgc gagcgcctgt gacagcggcg ccgctgtgct cgcgaccccg gctccgggcc      120

tctgccgacc tcaggggcag gaaagagtcg cccggcggga tgggcgggga ggctgggtgc      180

gcggcggccg tgggtgccga gggccgcgtg aagagcctgg gtctggtgtt cgaggacgag      240

cgcaagggct gctattccag cggcgagaca gtggccgggc acgtgctgct ggaggcgtcc      300

gagccggtgg ccctgcgcgc gctgcgcctg gaggcccagg ggcgcgccac cgccgcctgg      360

ggcccgagca cctgcccccg cgcctcggcc agcaccgcgg ccctggctgt cttctcggag      420

gtggagtacc tgaacgtgcg cctcagcctg cgggagcccc cggccggtga aggcatcatt      480

ttattacagc ctggaaaaca tgaatttcca tttcgctttc aacttccatc tgaacctttg      540

gtcacctcgt ttactgggaa atatggaagc attcagtact gtgtgcgggc agtgttggaa      600

cgacccaagg tacctgatca gagtgtaaag cgggaactcc aggttgttag tcatgtcgat      660

gtcaacacac cagcattatt aacccctgta ttgaaaactc aagagaaaat ggttggctgt      720

tggtttttca cttctggtcc agtctcgctg agtgccaaaa ttgaaagaaa gggatactgt      780

aatggagaag ctattccaat ctatgcagaa atagaaaatt gttcctctcg tctgattgtt      840

ccaaaggctg ctattttcca aacgcagaca tatttggcta gtggaaaaac aaagaccatt      900

cgacacatgg tcgccaatgt gcgaggaaac cacatcgctt ctgggagcac agacacatgg      960

aatgggaaaa cgctaaaaat cccacctgtt actccatcca tcctggattg ctgcattatc     1020

agagtggact attccttagc tgtatacatt cacattcctg gtgctaaaaa attgatgctc     1080

gaactgccat tagtgatcgg tacaattcca tataatggtt ttggcagcag aaactccagc     1140

attgccagcc agttcagtat ggatatgagc tggttgacac tgaccctgcc agagcagcct     1200

gaagcaccac caaattatgc agatgtggta tcagaggaag aattctctag acacattcct     1260

ccttaccctc aaccccctaa ctgtgaggga gaagtgtgct gtcctgtgtt tgcctgtata     1320

caagaattcc ggtttcaacc cccacctctt tattcagagg ttgacccaca tcctagcgac     1380

gtagaagaga gccagcctgt ttccttcatt ctctgaacgt atttcagaaa tcactgtgtt     1440

catcatcaaa ttagaatgtt ggttcttttc cttctgcctt tttgggaaag agacaggaaa     1500

gattcacttg aaaacataaa tgaacgtcaa gactgaaggc aatagaaatt aaagaatgtg     1560

agaaagttct ggtgggccgg caggattgcc gcacaagttt atatgatggt cgtatatata     1620

tccctgttaa aaactgggat gaagatgtgc aaagtcacag aatgtaatgg aagtcctgat     1680

ggttacagag taagtgaaag ggtgcctgcg ctgacgtgag agaaaggaat ctgtaaacag     1740

tggaaacact gtgggagttt cccatggtga agagtggaac gaaggcgata tgaactgaag     1800

gggtgaagac ttgattttgg agagggcaac aaaacaaggg tgtgtgtgca taggagaatg     1860

gcccactcca aatacgaagt gagatcctga gtctttgggt gcttcatgat ttcctaccat     1920

attcaggcct aaagacattg aaaaagcatc ttttcttgag atcatggtca tatgaggtcc     1980

taatgaagta ctacagtttt cattctttca agggtagact aaaatatagt ttataaatcg     2040

gcagtacggt attatgaaac caagaaaggg tttcttgaaa agcttgtcgg ttcaaagagg     2100

aaagatgaat ttcaatgtga aaacacgttt tgttgagggc tgtacttttt acccccttta     2160

agtgctttaa caggatatac gtttgatttt cctcatatct tatttaccta ggagcatgta     2220

agagaaagaa gggagagaaa aggttgcatc tgcaggatgc cttgataact acacagtccc     2280

aaataaaagg cctttttcta acctacctct aatggggtta tcagatatgt ttttaaatct     2340

ctcgccctga gtactcttct tgggagttgc tgctgtttac agccacagtc tcatctatca     2400

ctaaatatga aactgggcca aggggaaaat tcagtaagtt agcgttaaat ggaagtaaat     2460

atatgtatac ctaagagaat gtcaaaataa acaccaaacc aaaagaaggt aggagtgcca     2520

tttttagaaa agacacaact ttaattcctg tcaagagacc taggtctact gatggcagtc     2580

actgcattgt acattattcc agttcttcag taattctgtt taaactgtga ttttctttat     2640

tgtgttggtg caatatttta ttatcattta acctcaggat attcagacca acaggattgt     2700

gttgctgctg aaagtctgag cagtgtttta ccgtccccag cccccctccc acatggtcac     2760

atgttcactt gcttttcctt ccatctgttg gttttgtgag ctgagagcat ctctggacac     2820

atggaaggga gccagggatt cctgtgatac agattttgaa ccagcagagt actttggttt     2880

tcttcatgtc ctaagggttt gatccagaaa ccctggtgct tcccctgcag aatactgtac     2940

ttcatttaac agaatgattg atttttcttt caatcagcat gttcaccaaa aatagaaaag     3000

ttcttctaag gttaaatttt gtatttaaaa gttagttggc catttgatca gggaattttc     3060

tacacacatt aggcaaatgt atgcttttca tcctctgggc ttacctctct cctctgcaat     3120

cctggaagca tcgtgcatag ttctttcatt gtaagccgct atttaaattc ccacaatgca     3180

aaactgttag accagtaatt gtgctactga aattgtcaca aaacgttatt ccttgatttg     3240

gtttttaaat tttgctttcg tgtgtgtgtc tttaaacagg taatgtgtat ttaagtgttg     3300

tctaaacagt tgatttttac tttagaaaag atcatcttca actgtttatt gacttctgag     3360

ttatatagtt catgccctgc caaggcattg ttcgactcca tgatactaaa acataatgaa     3420

agaaacaaac tccagtatgg agaagagaaa gtttaattat ttggttccat ctagaaaagc     3480

aacaacttaa aggaatcctt cactaggatt gtcttatcac ctttattaga taaatcatga     3540

agtgtccctg tgaaattgaa gtgaaactat ctctgtagga cttaagagaa tagctaaaag     3600

gtgtgacttg ccttattgaa atgatactgg catatctgac tgtaagcagt aggttgaaga     3660

tatcatttta tgaatgtgga gaattctaca ttgaaacaga aaatacctgg gaatgaagat     3720

taaaaatgta gctgctgtta tttgcttggt tattcccctc ttgctcttct ttagtttgaa     3780

aaaacaaaaa cgtggccttg gaattttcat tttgatgcag aaattttgaa attgaaaatg     3840

tgcatgtttt ggtgcacaaa atccttctgt gggcaaaact ttgtttttgt tttgcacagt     3900

aagaaacaat aggcaagcgt tatgtttttg gtaagttaac tatgaaagct ttcttatttt     3960

tattattaaa aatgtaacaa tttaacccac aggaaaaaaa attactttgt atgcttgttt     4020

gaaccctatg ggttcgtttt attaataaaa ttattacact aatgctaaaa aaaa           4074


<210>  322
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  322

Met Gly Gly Glu Ala Gly Cys Ala Ala Ala Val Gly Ala Glu Gly Arg 
1               5                   10                  15      


Val Lys Ser Leu Gly Leu Val Phe Glu Asp Glu Arg Lys Gly Cys Tyr 
            20                  25                  30          


Ser Ser Gly Glu Thr Val Ala Gly His Val Leu Leu Glu Ala Ser Glu 
        35                  40                  45              


Pro Val Ala Leu Arg Ala Leu Arg Leu Glu Ala Gln Gly Arg Ala Thr 
    50                  55                  60                  


Ala Ala Trp Gly Pro Ser Thr Cys Pro Arg Ala Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Ala Leu Ala Val Phe Ser Glu Val Glu Tyr Leu Asn Val Arg Leu Ser 
                85                  90                  95      


Leu Arg Glu Pro Pro Ala Gly Glu Gly Ile Ile Leu Leu Gln Pro Gly 
            100                 105                 110         


Lys His Glu Phe Pro Phe Arg Phe Gln Leu Pro Ser Glu Pro Leu Val 
        115                 120                 125             


Thr Ser Phe Thr Gly Lys Tyr Gly Ser Ile Gln Tyr Cys Val Arg Ala 
    130                 135                 140                 


Val Leu Glu Arg Pro Lys Val Pro Asp Gln Ser Val Lys Arg Glu Leu 
145                 150                 155                 160 


Gln Val Val Ser His Val Asp Val Asn Thr Pro Ala Leu Leu Thr Pro 
                165                 170                 175     


Val Leu Lys Thr Gln Glu Lys Met Val Gly Cys Trp Phe Phe Thr Ser 
            180                 185                 190         


Gly Pro Val Ser Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Cys Asn 
        195                 200                 205             


Gly Glu Ala Ile Pro Ile Tyr Ala Glu Ile Glu Asn Cys Ser Ser Arg 
    210                 215                 220                 


Leu Ile Val Pro Lys Ala Ala Ile Phe Gln Thr Gln Thr Tyr Leu Ala 
225                 230                 235                 240 


Ser Gly Lys Thr Lys Thr Ile Arg His Met Val Ala Asn Val Arg Gly 
                245                 250                 255     


Asn His Ile Ala Ser Gly Ser Thr Asp Thr Trp Asn Gly Lys Thr Leu 
            260                 265                 270         


Lys Ile Pro Pro Val Thr Pro Ser Ile Leu Asp Cys Cys Ile Ile Arg 
        275                 280                 285             


Val Asp Tyr Ser Leu Ala Val Tyr Ile His Ile Pro Gly Ala Lys Lys 
    290                 295                 300                 


Leu Met Leu Glu Leu Pro Leu Val Ile Gly Thr Ile Pro Tyr Asn Gly 
305                 310                 315                 320 


Phe Gly Ser Arg Asn Ser Ser Ile Ala Ser Gln Phe Ser Met Asp Met 
                325                 330                 335     


Ser Trp Leu Thr Leu Thr Leu Pro Glu Gln Pro Glu Ala Pro Pro Asn 
            340                 345                 350         


Tyr Ala Asp Val Val Ser Glu Glu Glu Phe Ser Arg His Ile Pro Pro 
        355                 360                 365             


Tyr Pro Gln Pro Pro Asn Cys Glu Gly Glu Val Cys Cys Pro Val Phe 
    370                 375                 380                 


Ala Cys Ile Gln Glu Phe Arg Phe Gln Pro Pro Pro Leu Tyr Ser Glu 
385                 390                 395                 400 


Val Asp Pro His Pro Ser Asp Val Glu Glu Ser Gln Pro Val Ser Phe 
                405                 410                 415     


Ile Leu 
        


<210>  323
<211>  1851
<212>  DNA
<213>  Homo Sapiens

<400>  323
gtgcaggtga ggcacgttta gcctgagccg gccacggact ccacttcccc tgctcttccc       60

ccagtggcaa atccgcgcca cctcgcaaac ccccaactca ggcacttggg ccccttttgg      120

gccccctctc gctcctccct ttaggcacct ccctgggccc gcccacggtc tccccccagt      180

ttgggactgc gtcataagta tcccagacct cggcttgcag tagtgttaga ctgaagataa      240

agtaagtgct gtttgggcta acaggatctc ctcttgcagt ctgcagccca ggacgctgat      300

tccagcagcg ccttaccgcg cagcccgaag attcactatg gtgaaaatcg ccttcaatac      360

ccctaccgcc gtgcaaaagg aggaggcgcg gcaagacgtg gaggccctcc tgagccgcac      420

ggtcagaact cagatactga ccggcaagga gctccgagtt gccacccagg aaaaagaggg      480

ctcctctggg agatgtatgc ttactctctt aggcctttca ttcatcttgg caggacttat      540

tgttggtgga gcctgcattt acaagtactt catgcccaag agcaccattt accgtggaga      600

gatgtgcttt tttgattctg aggatcctgc aaattccctt cgtggaggag agcctaactt      660

cctgcctgtg actgaggagg ctgacattcg tgaggatgac aacattgcaa tcattgatgt      720

gcctgtcccc agtttctctg atagtgaccc tgcagcaatt attcatgact ttgaaaaggg      780

aatgactgct tacctggact tgttgctggg gaactgctat ctgatgcccc tcaatacttc      840

tattgttatg cctccaaaaa atctggtaga gctctttggc aaactggcga gtggcagata      900

tctgcctcaa acttatgtgg ttcgagaaga cctagttgct gtggaggaaa ttcgtgatgt      960

tagtaacctt ggcatcttta tttaccaact ttgcaataac agaaagtcct tccgccttcg     1020

tcgcagagac ctcttgctgg gtttcaacaa acgtgccatt gataaatgct ggaagattag     1080

acacttcccc aacgaattta ttgttgagac caagatctgt caagagtaag aggcaacaga     1140

tagagtgtcc ttggtaataa gaagtcagag atttacaata tgactttaac attaaggttt     1200

atgggatact caagatattt actcatgcat ttactctatt gcttatgctt taaaaaaagg     1260

aaaaaaaaaa actactaacc actgcaagct cttgtcaaat tttagtttaa ttggcattgc     1320

ttgttttttg aaactgaaat tacatgagtt tcattttttc tttgaattta tagggtttag     1380

atttctgaaa gcagcatgaa tatatcacct aacatcctga caataaattc catccgttgt     1440

tttttttgtt tgtttgtttt ttcttttcct ttaagtaagc tctttattca tcttatggtg     1500

gagcaatttt aaaatttgaa atattttaaa ttgtttttga actttttgtg taaaatatat     1560

cagatctcaa cattgttggt ttcttttgtt tttcattttg tacaactttc ttgaatttag     1620

aaattacatc tttgcagttc tgttaggtgc tctgtaatta acctgactta tatgtgaaca     1680

attttcatga gacagtcatt tttaactaat gcagtgattc tttctcacta ctatctgtat     1740

tgtggaatgc acaaaattgt gtaggtgctg aatgctgtaa ggagtttagg ttgtatgaat     1800

tctacaaccc tataataaat tttactctat acaaaaaaaa aaaaaaaaaa a              1851


<210>  324
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  324

Met Val Lys Ile Ala Phe Asn Thr Pro Thr Ala Val Gln Lys Glu Glu 
1               5                   10                  15      


Ala Arg Gln Asp Val Glu Ala Leu Leu Ser Arg Thr Val Arg Thr Gln 
            20                  25                  30          


Ile Leu Thr Gly Lys Glu Leu Arg Val Ala Thr Gln Glu Lys Glu Gly 
        35                  40                  45              


Ser Ser Gly Arg Cys Met Leu Thr Leu Leu Gly Leu Ser Phe Ile Leu 
    50                  55                  60                  


Ala Gly Leu Ile Val Gly Gly Ala Cys Ile Tyr Lys Tyr Phe Met Pro 
65                  70                  75                  80  


Lys Ser Thr Ile Tyr Arg Gly Glu Met Cys Phe Phe Asp Ser Glu Asp 
                85                  90                  95      


Pro Ala Asn Ser Leu Arg Gly Gly Glu Pro Asn Phe Leu Pro Val Thr 
            100                 105                 110         


Glu Glu Ala Asp Ile Arg Glu Asp Asp Asn Ile Ala Ile Ile Asp Val 
        115                 120                 125             


Pro Val Pro Ser Phe Ser Asp Ser Asp Pro Ala Ala Ile Ile His Asp 
    130                 135                 140                 


Phe Glu Lys Gly Met Thr Ala Tyr Leu Asp Leu Leu Leu Gly Asn Cys 
145                 150                 155                 160 


Tyr Leu Met Pro Leu Asn Thr Ser Ile Val Met Pro Pro Lys Asn Leu 
                165                 170                 175     


Val Glu Leu Phe Gly Lys Leu Ala Ser Gly Arg Tyr Leu Pro Gln Thr 
            180                 185                 190         


Tyr Val Val Arg Glu Asp Leu Val Ala Val Glu Glu Ile Arg Asp Val 
        195                 200                 205             


Ser Asn Leu Gly Ile Phe Ile Tyr Gln Leu Cys Asn Asn Arg Lys Ser 
    210                 215                 220                 


Phe Arg Leu Arg Arg Arg Asp Leu Leu Leu Gly Phe Asn Lys Arg Ala 
225                 230                 235                 240 


Ile Asp Lys Cys Trp Lys Ile Arg His Phe Pro Asn Glu Phe Ile Val 
                245                 250                 255     


Glu Thr Lys Ile Cys Gln Glu 
            260             


<210>  325
<211>  2418
<212>  DNA
<213>  Homo Sapiens

<400>  325
agccccagcc ccagccccgg ccccggcccc ggctcgcggg cgctgcgtct ccgcgtacag       60

gaggcggcgg cggctcccag tcaccggccc ccgccggcga gcgcacgatg cactgcctgg      120

gcgccgagta cctggtttct gcagaaggag cccctaggca aagggagtgg cgaccccaga      180

tttataggaa atgcacagat acggcatggt tattcctgtt ctttctcttt tggactggtt      240

tggtgtttat catgggctac tcggtggtgg ctggagccgc gggaagactc ctctttggct      300

atgacagctt tggcaacatg tgtggcaaga agaactcccc cgtggaaggg gcccctcttt      360

cagggcagga catgacccta aaaaaacacg tgttctttat gaattcctgc aacctggaag      420

tcaaaggtac gcagctcaac cgcatggccc tctgtgtatc caactgccct gaagagcagc      480

ttgactccct ggaagaggtc cagttctttg caaacaccag tgggtccttc ctgtgtgttt      540

atagtttgaa ttccttcaac tatacccaca gtccaaaagc agactcactg tgtcccaggc      600

taccagttcc tccaagcaag tcatttccct tatttaaccg atgtgtccct caaacacctg      660

agtgctactc cctatttgca tctgttttga taaatgatgt tgacaccctc caccgaattc      720

taagtggaat catgtcggga agagatacaa tccttggcct gtgtatcctc gcattagcct      780

tgtctttggc catgatgttt accttcagat tcatcaccac ccttctggtt cacattttca      840

tttcattggt tattttggga ttgttgtttg tctgcggtgt tttatggtgg ctgtattatg      900

actataccaa cgacctcagc atagaattgg acacagaaag ggaaaatatg aagtgcgtgc      960

tggggtttgc tatcgtatcc acaggcatca cggcagtgct gctcgtcttg atttttgttc     1020

tcagaaagag aataaaattg acagttgagc ttttccaaat cacaaataaa gccatcagca     1080

gtgctccctt cctgctgttc cagccactgt ggacatttgc catcctcatt ttcttctggg     1140

tcctctgggt ggctgtgctg ctgagcctgg gaactgcagg agctgcccag gttatggaag     1200

gcggccaagt ggaatataag cccctttcgg gcattcggta catgtggtcg taccatttaa     1260

ttggcctcat ctggactagt gaattcatcc ttgcgtgcca gcaaatgact atagctgggg     1320

cagtggttac ttgttatttc aacagaagta aaaatgatcc tcctgatcat cccatccttt     1380

cgtctctctc cattctcttc ttctaccatc aaggaaccgt tgtgaaaggg tcatttttaa     1440

tctctgtggt gaggattccg agaatcattg tcatgtacat gcaaaacgca ctgaaagaac     1500

agcagcatgg tgcattgtcc aggtacctgt tccgatgctg ctactgctgt ttctggtgtc     1560

ttgacaaata cctgctccat ctcaaccaga atgcatatac tacaactgct attaatggga     1620

cagatttctg tacatcagca aaagatgcat tcaaaatctt gtccaagaac tcaagtcact     1680

ttacatctat taactgcttt ggagacttca taatttttct aggaaaggtg ttagtggtgt     1740

gtttcactgt ttttggagga ctcatggctt ttaactacaa tcgggcattc caggtgtggg     1800

cagtccctct gttattggta gctttttttg cctacttagt agcccatagt tttttatctg     1860

tgtttgaaac tgtgctggat gcacttttcc tgtgttttgc tgttgatctg gaaacaaatg     1920

atggatcgtc agaaaagccc tactttatgg atcaagaatt tctgagtttc gtaaaaagga     1980

gcaacaaatt aaacaatgca agggcacagc aggacaagca ctcattaagg aatgaggagg     2040

gaacagaact ccaggccatt gtgagataga tacccattta ggtatctgta cctggaaaac     2100

atttccttct aagagccatt tacagaatag aagatgagac cactagagaa aagttagtga     2160

attttttttt aaaagaccta ataaacccta ttcttcctca ttgtctttgt cattattgtt     2220

tgaccaggta acaatactgg aactatatta gtttaccttt ttttgtacaa attaggacag     2280

aaaaactctt ctaaaaccat gtttatatgc atcaacttac aaagtacact atgtaagaac     2340

tgaggtaagt ttgtaagtgc acaactaata aataaacctt tttaagataa ggaaaaaaaa     2400

aaaaaaaaaa aaaaaaaa                                                   2418


<210>  326
<211>  653
<212>  PRT
<213>  Homo Sapiens

<400>  326

Met His Cys Leu Gly Ala Glu Tyr Leu Val Ser Ala Glu Gly Ala Pro 
1               5                   10                  15      


Arg Gln Arg Glu Trp Arg Pro Gln Ile Tyr Arg Lys Cys Thr Asp Thr 
            20                  25                  30          


Ala Trp Leu Phe Leu Phe Phe Leu Phe Trp Thr Gly Leu Val Phe Ile 
        35                  40                  45              


Met Gly Tyr Ser Val Val Ala Gly Ala Ala Gly Arg Leu Leu Phe Gly 
    50                  55                  60                  


Tyr Asp Ser Phe Gly Asn Met Cys Gly Lys Lys Asn Ser Pro Val Glu 
65                  70                  75                  80  


Gly Ala Pro Leu Ser Gly Gln Asp Met Thr Leu Lys Lys His Val Phe 
                85                  90                  95      


Phe Met Asn Ser Cys Asn Leu Glu Val Lys Gly Thr Gln Leu Asn Arg 
            100                 105                 110         


Met Ala Leu Cys Val Ser Asn Cys Pro Glu Glu Gln Leu Asp Ser Leu 
        115                 120                 125             


Glu Glu Val Gln Phe Phe Ala Asn Thr Ser Gly Ser Phe Leu Cys Val 
    130                 135                 140                 


Tyr Ser Leu Asn Ser Phe Asn Tyr Thr His Ser Pro Lys Ala Asp Ser 
145                 150                 155                 160 


Leu Cys Pro Arg Leu Pro Val Pro Pro Ser Lys Ser Phe Pro Leu Phe 
                165                 170                 175     


Asn Arg Cys Val Pro Gln Thr Pro Glu Cys Tyr Ser Leu Phe Ala Ser 
            180                 185                 190         


Val Leu Ile Asn Asp Val Asp Thr Leu His Arg Ile Leu Ser Gly Ile 
        195                 200                 205             


Met Ser Gly Arg Asp Thr Ile Leu Gly Leu Cys Ile Leu Ala Leu Ala 
    210                 215                 220                 


Leu Ser Leu Ala Met Met Phe Thr Phe Arg Phe Ile Thr Thr Leu Leu 
225                 230                 235                 240 


Val His Ile Phe Ile Ser Leu Val Ile Leu Gly Leu Leu Phe Val Cys 
                245                 250                 255     


Gly Val Leu Trp Trp Leu Tyr Tyr Asp Tyr Thr Asn Asp Leu Ser Ile 
            260                 265                 270         


Glu Leu Asp Thr Glu Arg Glu Asn Met Lys Cys Val Leu Gly Phe Ala 
        275                 280                 285             


Ile Val Ser Thr Gly Ile Thr Ala Val Leu Leu Val Leu Ile Phe Val 
    290                 295                 300                 


Leu Arg Lys Arg Ile Lys Leu Thr Val Glu Leu Phe Gln Ile Thr Asn 
305                 310                 315                 320 


Lys Ala Ile Ser Ser Ala Pro Phe Leu Leu Phe Gln Pro Leu Trp Thr 
                325                 330                 335     


Phe Ala Ile Leu Ile Phe Phe Trp Val Leu Trp Val Ala Val Leu Leu 
            340                 345                 350         


Ser Leu Gly Thr Ala Gly Ala Ala Gln Val Met Glu Gly Gly Gln Val 
        355                 360                 365             


Glu Tyr Lys Pro Leu Ser Gly Ile Arg Tyr Met Trp Ser Tyr His Leu 
    370                 375                 380                 


Ile Gly Leu Ile Trp Thr Ser Glu Phe Ile Leu Ala Cys Gln Gln Met 
385                 390                 395                 400 


Thr Ile Ala Gly Ala Val Val Thr Cys Tyr Phe Asn Arg Ser Lys Asn 
                405                 410                 415     


Asp Pro Pro Asp His Pro Ile Leu Ser Ser Leu Ser Ile Leu Phe Phe 
            420                 425                 430         


Tyr His Gln Gly Thr Val Val Lys Gly Ser Phe Leu Ile Ser Val Val 
        435                 440                 445             


Arg Ile Pro Arg Ile Ile Val Met Tyr Met Gln Asn Ala Leu Lys Glu 
    450                 455                 460                 


Gln Gln His Gly Ala Leu Ser Arg Tyr Leu Phe Arg Cys Cys Tyr Cys 
465                 470                 475                 480 


Cys Phe Trp Cys Leu Asp Lys Tyr Leu Leu His Leu Asn Gln Asn Ala 
                485                 490                 495     


Tyr Thr Thr Thr Ala Ile Asn Gly Thr Asp Phe Cys Thr Ser Ala Lys 
            500                 505                 510         


Asp Ala Phe Lys Ile Leu Ser Lys Asn Ser Ser His Phe Thr Ser Ile 
        515                 520                 525             


Asn Cys Phe Gly Asp Phe Ile Ile Phe Leu Gly Lys Val Leu Val Val 
    530                 535                 540                 


Cys Phe Thr Val Phe Gly Gly Leu Met Ala Phe Asn Tyr Asn Arg Ala 
545                 550                 555                 560 


Phe Gln Val Trp Ala Val Pro Leu Leu Leu Val Ala Phe Phe Ala Tyr 
                565                 570                 575     


Leu Val Ala His Ser Phe Leu Ser Val Phe Glu Thr Val Leu Asp Ala 
            580                 585                 590         


Leu Phe Leu Cys Phe Ala Val Asp Leu Glu Thr Asn Asp Gly Ser Ser 
        595                 600                 605             


Glu Lys Pro Tyr Phe Met Asp Gln Glu Phe Leu Ser Phe Val Lys Arg 
    610                 615                 620                 


Ser Asn Lys Leu Asn Asn Ala Arg Ala Gln Gln Asp Lys His Ser Leu 
625                 630                 635                 640 


Arg Asn Glu Glu Gly Thr Glu Leu Gln Ala Ile Val Arg 
                645                 650             


<210>  327
<211>  9288
<212>  DNA
<213>  Homo Sapiens

<400>  327
agtgctcgcc cgcccgaccc cggcggctcg cgcccgggag cgccgcaggg tcgctagagt       60

cggccgcgtc ctttgtgtgg cgctcaggct gcgccgcggg gcggcgggac ggaatgtggg      120

cgctgcgggg gcttttctct cctacccgaa ctgtgggaac aatggactga aaggggaaga      180

tggattgagg ggccgagcgg ggaagcgagc tgcaccgggg aatcatgact tctgcagccg      240

agataaagaa gccaccagtg gcccccaagc ccaagtttgt tgtggcaaat aataagccag      300

ccccacctcc tattgcacct aaacccgaca ttgtgatttc tagtgttcca cagtcgacaa      360

agaaaatgaa accagcaata gccccaaaac caaaagtcct gaagacctca cctgttcgag      420

agattgggca gtcgccatca aggaaaatca tgttgaacct ggaagggcat aaacaggaat      480

tagctgaaag cactgacaac tttaattgta aatatgaagg caatcagagc aatgattata      540

tttcaccaat gtgttcctgc agttctgagt gtatccataa gctgggccat agagagaatt      600

tgtgtgtaaa gcagcttgtt ttagagcccc tggaaatgaa tgaaaattta gaaaacagta      660

aaattgatga gactttgact ataaaaacta ggagtaaatg tgatttgtat ggtgaaaaag      720

ccaagaacca gggtggggtt gttttaaagg caagcgtttt agaagaggag ctcaaagatg      780

ccttaataca ccaaatgcca ccttttattt ctgcacagaa gcacaggccc acagacagcc      840

cagaaatgaa tggtggctgt aattcaaatg gacaattcag aattgaattt gcggatttgt      900

caccttcccc atccagcttt gaaaaagttc ctgatcatca cagttgccac ttacagcttc      960

ctagtgatga atgtgaacat tttgaaactt gccaggatga cagtgaaaaa agcaataatt     1020

gctttcagtc atctgaacta gaggctctgg aaaatgggaa aaggagtact ttaatatctt     1080

cagatggagt tagtaagaaa tcagaagtca aagaccttgg tcccttagaa attcatttag     1140

taccatatac cccaaaattt ccaactccca agcccagaaa gacacgaact gctcgtctgt     1200

tacgccaaaa gtgtgtagat actcctagtg aaagcactga agaaccgggg aattcagaca     1260

gtagctcttc ctgtcttact gaaaatagtt tgaaaatcaa taaaatcagt gttctgcatc     1320

agaatgtttt gtgtaagcag gaacaggtgg ataaaatgaa gctaggaaat aaaagtgaat     1380

tgaatatgga atccaacagt gatgcacagg acttagtcaa ttcacagaaa gccatgtgta     1440

atgaaacaac ttcctttgaa aaaatggcac cttcttttga taaagactct aatttgagtt     1500

ctgacagcac aactgtagat ggttctagta tgtcgcttgc tgtggacgaa gggaccggtt     1560

ttataagatg tactgtatct atgagcctgc ctaagcagct caaattaact tgcaatgaac     1620

atttgcaatc tgggagaaac ctgggagttt ctgcccctca aatgcaaaag gaatctgtta     1680

taaaagagga aaattctcta cgaattgtcc ccaaaaaacc tcaaagacat agcttgcctg     1740

ctacaggagt gcttaaaaag gctgcctccg aggagctttt ggaaaaaagt tcttatcctt     1800

caagtgaaga aaaaagttca gagaagagtc tagaaagaaa tcaccttcag catttgtgtg     1860

cccaaaaccg tggtgtgtca tcctcctttg atatgcctaa acgggcttca gaaaagccag     1920

tgtggaagtt acctcatcct attttaccct tttcagggaa cccagaattc ttaaagtctg     1980

tcaccgtatc gtcaaacagt gagccttcaa cagccctaac caagcccaga gcaaaatcgt     2040

tatctgctat ggatgtggaa aagtgcacta agccttgcaa agactctaca aagaaaaact     2100

cttttaaaaa gttgctcagc atgaaactgt ccatctgttt catgaagagt gactttcaaa     2160

aattttggtc caagagtagc caactcggag acaccaccac aggccacctc tccagtgggg     2220

agcagaaggg gattgaaagt gattggcaag gcttgttggt aggagaggag aagagaagta     2280

aacccatcaa ggcatattcc acagaaaact atagcctgga atctcaaaag aagaggaaga     2340

agtctcgggg ccagaccagt gcagctaatg gtctgagagc tgagtctttg gatgaccaaa     2400

tgctctcccg ggagtcatca tctcaggcac cttacaagtc tgttacaagc ctctgtgcac     2460

cggagtatga aaatatacgc cattatgagg aaataccaga gtacgagaac ttgccattta     2520

ttatggctat acggaaaact caagagttgg aatggcagaa ttccagcagc atggaggacg     2580

ctgatgcaaa tgtgtatgag gtagaagagc cgtatgaagc tccagatggc cagctgcagc     2640

ttggacccag acatcagcat tccagttcag gagcatccca ggaggaacag aatgatcttg     2700

gtcttggtga ccttccctct gatgaggagg aaatcatcaa cagttctgat gaagatgatg     2760

tcagctctga gtcaagtaaa ggagagcctg acccactgga agataaacag gatgaagata     2820

atggaatgaa aagtaaagtt catcatattg ccaaggagat catgagctca gagaaagtgt     2880

ttgtggatgt gttaaaactt ttgcatattg atttccggga tgcagtagct catgcttcca     2940

ggcaacttgg gaaaccagtg attgaggacc ggattctaaa tcagatccta tactacttgc     3000

ctcagctgta tgagctcaac cgggatctct tgaaggaact ggaggaaaga atgttgcact     3060

ggactgaaca acaaagaatt gctgatatct ttgtaaagaa gggaccatat ctaaaaatgt     3120

attccacata catcaaagaa tttgataaga atatagcctt gctggatgaa cagtgcaaga     3180

aaaatccagg ttttgctgct gttgttagag aatttgagat gagccctcgc tgtgctaatc     3240

tggccctcaa gcactacctg ctcaagccgg ttcagaggat cccccagtac aggctgttgc     3300

tgacagatta tttgaagaat ctcatagaag atgctggaga ttacagagac actcaagatg     3360

cccttgctgt tgttatagag gtagccaacc acgccaatga caccatgaag caaggagaca     3420

actttcagaa acttatgcaa attcagtaca gcttaaatgg acaccatgaa attgtgcagc     3480

ctggtcgggt ttttctcaaa gaaggaattc tgatgaagct gtctcggaaa gtgatgcaac     3540

ctcgaatgtt tttcctgttt aatgatgccc tgctgtatac aacaccagtg cagtctggga     3600

tgtataaact gaacaacatg ctctcactgg ctggaatgaa ggtcagaaaa cctacccaag     3660

aagcctatca gaatgaatta aagattgaaa gtgtagaacg ttccttcatt ctctcagcca     3720

gttctgccac agaaagggat gaatggctag aagcgatttc cagggcaata gaagagtatg     3780

ccaagaaaag aatcaccttc tgtcctagta ggagtcttga tgaggcagac tcagaaaata     3840

aagaagaagt tagtcctctt ggatcgaagg ctcccatctg gattcctgat accagagcca     3900

caatgtgtat gatctgcaca agcgaattca ctctcacctg gagacgacac cactgccggg     3960

cctgtggaaa gattgtatgc caagcttgtt cgtctaataa gtatggctta gattacctga     4020

aaaatcaacc agcaagagta tgtgaacatt gtttccaaga actgcagaaa ttagatcacc     4080

agcactcccc taggattgga tctcctggaa atcacaaatc tccttcaagt gccttatcat     4140

cagtcttaca tagcattcca tcagggagga aacagaaaaa aatcccagct gctctcaaag     4200

aagtatcagc aaacacagag gattcttcta tgagtggcta cttgtacaga tcaaagggca     4260

ataaaaaacc ctggaaacac ttttggtttg tcataaaaaa taaagtacta tatacatatg     4320

ctgcaagtga ggacgtggcc gctttggaga gtcagccttt attaggattc actgttattc     4380

aagttaaaga tgagaattcc gagtctaaag tatttcagtt actgcacaaa aacatgttat     4440

tttatgtatt caaagcagag gatgctcatt cggctcagaa gtggatagaa gcatttcagg     4500

aaggcacaat attgtagcag tattggtttc atctcttctg tgattccaaa gaggtggaat     4560

ttcatcagaa tggagtaaat gcaattcaaa aattgtataa aaatgaacac tgccaagata     4620

aagccaacca gacccttcat caaagaaatt gttttgttag gtataagcaa tttttaaaag     4680

gtgtttgttt tttcatttat gttatttatt aaaattttga tgtttactta atggtcagaa     4740

ttatttctga gacacactga attctaaagt accatttctt tagagaccag aaaaactatc     4800

ttaatactgt atactgtatt aactattcgt gacatagttc acactgtttt cttaccttac     4860

attgtaacaa tcttactggt ggaaagtctt tgtaaggaaa aaacacatag caaggagcaa     4920

atttccacaa agtgcttggt ttaggaattg tgattattat aaaactgctg atgaaaaaaa     4980

tgcatgtctt tgaatcaata aacttgggtg aatatttgta tcttttagtg gaaaaacatg     5040

gccagcttct acctcagtaa ctgtgaactg aaatttcagt aaattatcta aagtatttct     5100

gttgttaggt acctctttgg caggagttaa tattacatca tcaaagaatt atagcaaaga     5160

gatagaatct gaatttttta aaactgtgag taggaatgaa gatgttttta tttgcagaat     5220

accacaaata accaactctt ccggctttta agtccaatct tttaaaaaat ctaccacttc     5280

gaaacaaaca taaatgtatc attttttaaa atagcaaaat atagcaagca ttatgtcaca     5340

taatattccc tgctattata agagttctga gcccaagtca atgatgatat ttgtatctat     5400

aagtaatgtt acatttccaa aaatattgtg cattacaaat ggaactggaa ttactatatc     5460

agaaaagcat aattataagc cagtaataac tgaaattcta tagtattcat tttcaaaagg     5520

tctttttctg ccagtttgtg atatcctccc tcctaattaa aaaaaaaaac aacaaatcct     5580

ttctctataa gcagctatca gcacacctcc ttaggaaaga tttagattca taattctggt     5640

gcacttactg tttaacatat gaactacctt gcacatacaa ttgttgatta gcagaagaaa     5700

atgaaataac actgtgataa aagccatccc tgatgttcac aatacacaat ttattaacta     5760

agtttaaact ataaattatc ttaactgcca tgagcggtgg ctcacaccta caatctcagc     5820

attttgggag gccgaggccg ttggaccacc tgaggtcagg agatcgagac cagcctggcc     5880

aatatggtga aaccccatct ctattaaaaa tacaagaatt agccggtcgt ggtggtacat     5940

ggctgtagtc ctagctattc agcaggctga ggcaggagca tcgcttgaac ccaggaggca     6000

gaggttgcag tgagccgaga tggtgccact gcactccagc ctgggatgac agagcgagac     6060

tccatctcaa aaaaaaaaaa aaaaaaaaaa ttgaacagca aggttatcca tataatattt     6120

ctttaaaggg tacaagaatt ttcctttctg cctctaaata aaggatttcc taattcagtg     6180

tgatccttaa cagcaaccat gaggattact gagtgccttt ctggggcctt ttgaatgctg     6240

tttggtacag caccagagtc cctactagat ctagagttgg ctgctatagt tttttgtggc     6300

gattttttgc catggagtca tttgaacctc atacacaatc ctaacatgcc atcccctttc     6360

tgtcatagca ggtacactaa aatttctttg tagctcaatt ttatataatc aagatcacat     6420

aaataaggct tccatgttag aatcgttgca gtttttagtg tattcctttt tggaggctaa     6480

agttgtacct tataaactgt ttctgcgtct ggcatttagc aagacaagtt atttgggttt     6540

tctttccctc ctcttgagct ctcagccttc tgactacaag gtttggctta agccttataa     6600

tctaaaaaat atcagccagg ctattctatc ttctaagacc tggctgaatc atgagccagt     6660

tctaaatcta aagagagtga gagagggaag aaatctggca caaacttaca gtctctttaa     6720

ttacatgtaa aatgcatgtg actgtattac ctattggctt agccccatgg agggtttaga     6780

aaaatgtgta gtctttgtgg aagctatcca attatccttc tcccaaaaag atgttttaaa     6840

tgtggaatag tattacattc ccctgcccct ttatgagtcc ttcataactt actaaagctg     6900

accaattgtt atttatgtaa cctggctcat tcattgtcaa ctaagaacct aattatatgc     6960

aatttattgt aaaaaaagct ataaaaatat attttgctag tattttagag gaaaaatgat     7020

attgggcaca gtctataaat ggggagaaaa gttaagtagt atctagattc caaggatact     7080

atatttatta tacagatatg tgtgcctgtg cttccatcaa accctttttc aggtatctcc     7140

ttttaattca taaggaggaa agagtagggc atttataaag ctaagctaaa aatgatgcta     7200

agcataacgt agatgagacg ccaggctgaa ccaggggaag gctggcattg ttagtgtccc     7260

caactagcag tccaccttta tctgtggcag ctataaatgt acaggaccca tcagagtcct     7320

aagaaaatga gagtaattat ctctggcatc atccacattt ccgactcttt ccaatctctt     7380

ttcccttttt ctgtaatgta cccagcatcc ccctattgta ttttggttgc ccaagattct     7440

tgattctttg agtgtgtagt agcatttctt aaaatgagat catcagacca acccttgatt     7500

cacatgaaag ctgtaatgac acaacaaaga gaaggcgaca gttttaaagt ataattgtca     7560

gccaaatgtg tattttatat ttggttcata gaatatatct agatgtgggg aaagtctcct     7620

atttggtaat ttagttaaaa tgtaaatgtt atatcacagc atatgttggt atgttttgga     7680

gtgtgcttcc attgtgctca gcttttgaaa agtttgaaat ccactttagt caaatgtagt     7740

caatgggatt tccagagata catattgttt ttcttagtgt accacacact ccttgaaggc     7800

agatactgta cttaatatat cactgtcttc cataatactg ccctaggtct ttttagtttt     7860

taagagaccg ggtctcgcta tgtttcccat gctgaactca aatgcctggg cttaagcaat     7920

cctcccacct cagcctctgg agtagctggg actacagggg catgcaccac caggcctggc     7980

ttcctaggag ggtctttaaa gagaaaatat ttgttcaatt gaaaacagga ttcttgtcat     8040

ctacaactcc aacacagcct gaaaatatcc acattataac ctggacctta gacctacttt     8100

ctccactatc ctgcaaagct acatctgtaa ctacctattg gctatctata tgagtcctca     8160

agcatctcag actttacatg aataaaactc aacttccttc ccattcaaat ctgtttattt     8220

tcttctgtaa gagaaagata ccatttgaga ctccagaatc tgcctctaac tctcaacaag     8280

actctgcaat tactcaagta tcctttccat cctcattgcc ctgctgttat tacataggcc     8340

ctggttcaag tccttgttac ttgttcccat tattgcaata acttctaatt ccaatgccgt     8400

tgtgtgatcc cattttaaac acggccagag cagtcttcca acaacatagc tctaatctag     8460

tttcatcccc acttttacat gcctcagtgg ctttcccagt gacttggcat ggaacacgtc     8520

ctcagttgcc atacattcca gctaactctt acccaacctt tctttgttca cacagtttcc     8580

ttttccttcc tcattgaccc atccgcatct ctgtttatcc aagacttctc tgtgatagct     8640

gacccttagt ctttctctcc cctattcctc cagactagat cctgtctcct tcctgcagcc     8700

ccgacacagc cttcagttca tatcttttgc atgatgctta gcaccttcta tccctaagga     8760

caacttactc atttgagatt tctggcaggg taccttgcat gcagtggaca ctcagtattt     8820

gctgaattaa attccttcct atggatccct tctgattttt tttaagtgcc tctaatacac     8880

atatcattct agggctcatg ccacttttaa tgtcattttc taaaggaaaa tcttatctat     8940

gatattttcc cttataagag atagttgttt tgagtagggt tttttaaaag ataaaggtag     9000

taggaaattt tttaaagcct aaatatcaaa ttcctttccc tttggagttg ggggaaggaa     9060

tgaaggggga gcaacttgct ctttcatatg agttggtcat agcatgtaag aaccaatctt     9120

gaaatatcgt ttttttttta atggcttata atgtatttct agaaatactt tgtacttaaa     9180

atgataacag tttgtatctt tttgtccata tatactttat aaataaaaaa attagcattg     9240

taaataatgt taatatgtat ttatacaaaa taaatttact ataatata                  9288


<210>  328
<211>  1430
<212>  PRT
<213>  Homo Sapiens

<400>  328

Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 
    1205                 1210                 1215             


Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 
    1220                 1225                 1230             


Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 
    1235                 1240                 1245             


Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 
    1250                 1255                 1260             


Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 
    1265                 1270                 1275             


Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 
    1280                 1285                 1290             


Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 
    1295                 1300                 1305             


His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 
    1310                 1315                 1320             


Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 
    1325                 1330                 1335             


Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 
    1340                 1345                 1350             


Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 
    1355                 1360                 1365             


Glu Asp  Val Ala Ala Leu Glu  Ser Gln Pro Leu Leu  Gly Phe Thr 
    1370                 1375                 1380             


Val Ile  Gln Val Lys Asp Glu  Asn Ser Glu Ser Lys  Val Phe Gln 
    1385                 1390                 1395             


Leu Leu  His Lys Asn Met Leu  Phe Tyr Val Phe Lys  Ala Glu Asp 
    1400                 1405                 1410             


Ala His  Ser Ala Gln Lys Trp  Ile Glu Ala Phe Gln  Glu Gly Thr 
    1415                 1420                 1425             


Ile Leu  
    1430 


<210>  329
<211>  6932
<212>  DNA
<213>  Homo Sapiens

<400>  329
gcatttaaaa gacagcgtga gactcgcgcc ctccggcacg gaaaaggcca ggcgacaggt       60

gtcgcttgaa aagactgggc ttgtccttgc tggtgcatgc gtcgtcggcc tctgggcagc      120

aggtttacaa aggaggaaaa cgacttcttc tagatttttt tttcagtttc ttctataaat      180

caaaacatct caaaatggag acctaaaatc cttaaaggga cttagtctaa tctcgggagg      240

tagttttgtg catgggtaaa caaattaagt attaactggt gttttactat ccaaagaatg      300

ctaattttat aaacatgatc gagttatata aggtatacca taatgagttt gattttgaat      360

ttgatttgtg gaaataaagg aaaagtgatt ctagctgggg catattgtta aagcattttt      420

ttcagagttg gccaggcagt ctcctactgg cacattctcc cattatgtag aatagaaata      480

gtacctgtgt ttgggaaaga ttttaaaatg agtgacagtt atttggaaca aagagctaat      540

aatcaatcca ctgcaaatta aagaaacatg cagatgaaag ttttgacaca ttaaaatact      600

tctacagtga caaagaaaaa tcaagaacaa agctttttga tatgtgcaac aaatttagag      660

gaagtaaaaa gataaatgtg atgattggtc aagaaattat ccagttattt acaaggccac      720

tgatatttta aacgtccaaa agtttgttta aatgggctgt taccgctgag aatgatgagg      780

atgagaatga tggttgaagg ttacatttta ggaaatgaag aaacttagaa aattaatata      840

aagacagtga tgaatacaaa gaagattttt ataacaatgt gtaaaatttt tggccaggga      900

aaggaatatt gaagttagat acaattactt acctttgagg gaaataattg ttggtaatga      960

gatgtgatgt ttctcctgcc acctggaaac aaagcattga agtctgcagt tgaaaagccc     1020

aacgtctgtg agatccagga aaccatgctt gcaaaccact ggtaaaaaaa aaaaaaaaaa     1080

aaaaaaaaag ccacagtgac ttgcttattg gtcattgcta gtattatcga ctcagaacct     1140

ctttactaat ggctagtaaa tcataattga gaaattctga attttgacaa ggtctctgct     1200

gttgaaatgg taaatttatt attttttttg tcatgataaa ttctggttca aggtatgcta     1260

tccatgaaat aatttctgac caaaactaaa ttgatgcaat ttgattatcc atcttagcct     1320

acagatggca tctggtaact tttgactgtt ttaaaaaata aatccactat cagagtagat     1380

ttgatgttgg cttcagaaac atttagaaaa acaaaagttc aaaaatgttt tcaggaggtg     1440

ataagttgaa taactctaca atgttagttc tttgaggggg acaaaaaatt taaaatcttt     1500

gaaaggtctt attttacagc catatctaaa ttatcttaag aaaattttta acaaagggaa     1560

tgaaatatat atcatgattc tgtttttcca aaagtaacct gaatatagca atgaagttca     1620

gttttgttat tggtagtttg ggcagagtct ctttttgcag cacctgttgt ctaccataat     1680

tacagaggac atttccatgt tctagccaag tatactatta gaataaaaaa acttaacatt     1740

gagttgcttc aacagcatga aactgagtcc aaaagaccaa atgaacaaac acattaatct     1800

ctgattattt attttaaata gaatatttaa ttgtgtaaga tctaatagta tcattatact     1860

taagcaatca tattcctgat gatctatggg aaataactat tatttaatta atattgaaac     1920

caggttttaa gatgtgttag ccagtcctgt tactagtaaa tctctttatt tggagagaaa     1980

ttttagattg ttttgttctc cttattagaa ggattgtaga aagaaaaaaa tgactaattg     2040

gagaaaaatt ggggatatat catatttcac tgaattcaaa atgtcttcag ttgtaaatct     2100

taccattatt ttacgtacct ctaagaaata aaagtgcttc taattaaaat atgatgtcat     2160

taattatgaa atacttcttg ataacagaag ttttaaaata gccatcttag aatcagtgaa     2220

atatggtaat gtattatttt cctcctttga gttaggtctt gtgctttttt ttcctggcca     2280

ctaaatttca caatttccaa aaagcaaaat aaacatattc tgaatatttt tgctgtgaaa     2340

cacttgacag cagagctttc caccatgaaa agaagcttca tgagtcacac attacatctt     2400

tgggttgatt gaatgccact gaaacattct agtagcctgg agaagttgac ctacctgtgg     2460

agatgcctgc cattaaatgg catcctgatg gcttaataca catcactctt ctgtgaaggg     2520

ttttaatttt caacacagct tactctgtag catcatgttt acattgtatg tataaagatt     2580

atacaaaggt gcaattgtgt atttcttcct taaaatgtat cagtatagga tttagaatct     2640

ccatgttgaa actctaaatg catagaaata aaaataataa aaaatttttc attttggctt     2700

ttcagcctag tattaaaact gataaaagca aagccatgca caaaactacc tccctagaga     2760

aaggctagtc ccttttcttc cccattcatt tcattatgaa catagtagaa aacagcatat     2820

tcttatcaaa tttgatgaaa agcgccaaca cgtttgaact gaaatacgac ttgtcatgtg     2880

aactgtaccg aatgtctacg tattccactt ttcctgctgg ggttcctgtc tcagaaagga     2940

gtcttgctcg tgctggtttc tattacactg gtgtgaatga caaggtcaaa tgcttctgtt     3000

gtggcctgat gctggataac tggaaaagag gagacagtcc tactgaaaag cataaaaagt     3060

tgtatcctag ctgcagattc gttcagagtc taaattccgt taacaacttg gaagctacct     3120

ctcagcctac ttttccttct tcagtaacaa attccacaca ctcattactt ccgggtacag     3180

aaaacagtgg atatttccgt ggctcttatt caaactctcc atcaaatcct gtaaactcca     3240

gagcaaatca agatttttct gccttgatga gaagttccta ccactgtgca atgaataacg     3300

aaaatgccag attacttact tttcagacat ggccattgac ttttctgtcg ccaacagatc     3360

tggcaaaagc aggcttttac tacataggac ctggagacag agtggcttgc tttgcctgtg     3420

gtggaaaatt gagcaattgg gaaccgaagg ataatgctat gtcagaacac ctgagacatt     3480

ttcccaaatg cccatttata gaaaatcagc ttcaagacac ttcaagatac acagtttcta     3540

atctgagcat gcagacacat gcagcccgct ttaaaacatt ctttaactgg ccctctagtg     3600

ttctagttaa tcctgagcag cttgcaagtg cgggttttta ttatgtgggt aacagtgatg     3660

atgtcaaatg cttttgctgt gatggtggac tcaggtgttg ggaatctgga gatgatccat     3720

gggttcaaca tgccaagtgg tttccaaggt gtgagtactt gataagaatt aaaggacagg     3780

agttcatccg tcaagttcaa gccagttacc ctcatctact tgaacagctg ctatccacat     3840

cagacagccc aggagatgaa aatgcagagt catcaattat ccattttgaa cctggagaag     3900

accattcaga agatgcaatc atgatgaata ctcctgtgat taatgctgcc gtggaaatgg     3960

gctttagtag aagcctggta aaacagacag ttcagagaaa aatcctagca actggagaga     4020

attatagact agtcaatgat cttgtgttag acttactcaa tgcagaagat gaaataaggg     4080

aagaggagag agaaagagca actgaggaaa aagaatcaaa tgatttatta ttaatccgga     4140

agaatagaat ggcacttttt caacatttga cttgtgtaat tccaatcctg gatagtctac     4200

taactgccgg aattattaat gaacaagaac atgatgttat taaacagaag acacagacgt     4260

ctttacaagc aagagaactg attgatacga ttttagtaaa aggaaatatt gcagccactg     4320

tattcagaaa ctctctgcaa gaagctgaag ctgtgttata tgagcattta tttgtgcaac     4380

aggacataaa atatattccc acagaagatg tttcagatct accagtggaa gaacaattgc     4440

ggagactaca agaagaaaga acatgtaaag tgtgtatgga caaagaagtg tccatagtgt     4500

ttattccttg tggtcatcta gtagtatgca aagattgtgc tccttcttta agaaagtgtc     4560

ctatttgtag gagtacaatc aagggtacag ttcgtacatt tctttcatga agaagaacca     4620

aaacatcgtc taaactttag aattaattta ttaaatgtat tataacttta acttttatcc     4680

taatttggtt tccttaaaat ttttatttat ttacaactca aaaaacattg ttttgtgtaa     4740

catatttata tatgtatcta aaccatatga acatatattt tttagaaact aagagaatga     4800

taggcttttg ttcttatgaa cgaaaaagag gtagcactac aaacacaata ttcaatcaaa     4860

atttcagcat tattgaaatt gtaagtgaag taaaacttaa gatatttgag ttaaccttta     4920

agaattttaa atattttggc attgtactaa taccgggaac atgaagccag gtgtggtggt     4980

atgtgcctgt agtcccaggc tgaggcaaga gaattacttg agcccaggag tttgaatcca     5040

tcctgggcag catactgaga ccctgccttt aaaaacaaac agaacaaaaa caaaacacca     5100

gggacacatt tctctgtctt ttttgatcag tgtcctatac atcgaaggtg tgcatatatg     5160

ttgaatgaca ttttagggac atggtgtttt tataaagaat tctgtgagaa aaaatttaat     5220

aaagcaacaa aaattactct tattcttcat tgctttattt caatgacatt ggatagttta     5280

gtcactccca gactctttcc ataccttctt aaagcctctc aaatattgaa ctacagttta     5340

tactccttcc cataagatgc ttcttcattg acacttgtag aacacggggt caacacatca     5400

taaaatctat tatggaatgc ctgagacaag aatcaaacag tccctttagt aagtttgttt     5460

attcacttct ctattgattc attcaagaag tctcatgcca gccccaccta ttggaagaag     5520

gtctgagttt tattcttatc tctttggtat taattctgaa acttagaaag tacactggtt     5580

agcaatgctt gggaccaaca ggttgttctg gtaaataaat ctgtttcata ttgtcagtgc     5640

aacaaaatgt ccccctctgc attatgttat tggtactcaa cacgtccgag tcataactct     5700

gtcctttgct tcttatagag gtattaggtc ttcaagagca gaagtaagac tgtaataggg     5760

aatactcagg ggaaggcagg caaaggctag tcatctaaac cagttctaga tgtctgtata     5820

ggggcagatg gctctgtaag ggcagaaggg aaagacccct tcataagggt cacagctgac     5880

aatcctataa caaaagacag gttaacaaga gaaaaactta acaaatttat ttaatcacag     5940

atttacatca ccggggagcc ttcgtaatga agatccaaaa ttacagggga aactgtgcat     6000

ttttatgctt aggtttgata atgaatggac agccctgaag aatagtgatt ggaaaaaaag     6060

gatatgatct aatgggaata gacacaggtt ggggacccag caaggcctgt ctgttcagat     6120

tattcttggt ctctgtgcag cattccttcc tcctggatat agggcagggc ctgtatggga     6180

tggggatatt ataacctgct atcaagcaag gtaggtcaga gaatttattt atggccagct     6240

cttacatagt taggtgagga aagattagag tactatcttt aagatgtaag tctggcattg     6300

tggaaagatg gttccagttt ctatgaccta ccttggggaa gaggaattca agtttctgtg     6360

gcttgccttc agggagaatg aggctgagac aggagggcag gataacatca gagaaaaact     6420

ttgcttctga ggccttcact ttgggttttc tgagccccaa catctgctag tgttgtaaag     6480

agaacaatta gggaccaagt gaggggagga aagaatccat ctctgcattc tgatgctggg     6540

agacttattt ccttgaaatg caattgattt tgcctctgct aagaggctct gctggctacc     6600

catgtactag ccagtgtcct gcatgggtgc taggctgaat tatttgtaat tgtgcttagg     6660

tgatttgtaa ctcaggtata gggtatttaa atagtaggca ccctttttgc accatgtgtt     6720

ttttttttta tctagttctt gtatactaca gataatattt gaactttgtc atctcactgt     6780

aaaacttttg ttcatttctc attatggtaa taaatagcta ttataaccaa cccatttatt     6840

caaatatgtt atttccctaa gtgttatttt gacattttgt tttggaaaaa ataaatcacc     6900

atagataata aaaaaaaaaa aaaaaaaaaa aa                                   6932


<210>  330
<211>  604
<212>  PRT
<213>  Homo Sapiens

<400>  330

Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr 
            100                 105                 110         


Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe 
                165                 170                 175     


Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala 
                245                 250                 255     


Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
        595                 600                 


<210>  331
<211>  9454
<212>  DNA
<213>  Homo Sapiens

<400>  331
cacacagtga tttctgttat ggcgattggg cggctgcaga gaccaggact cagttcccct       60

gccctagtct gagcctagtg ggtgggactc agctcagagt cagttttcca gaagcaggtt      120

tcagtgcaga gttttcctac acttttcctg cgctagagca gcgagcagcc tggaacagac      180

ccaggcggag gacacctgtg ggggagggag cgcctggagg agcttagaga ccccagccgg      240

gcgtgatctc accatgtgcg gatttgcgag gcgcgccctg gagctgctag agatccggaa      300

gcacagcccc gaggtgtgcg aagccaccaa gactgcggct cttggagaaa gcgtgagcag      360

ggggccaccg cggtctccgc gcctgtctgc accctgtcgc ctgagctgcc tgacagtgac      420

aatgacatcc cagttaccag tgtccttgaa ttgatagtgg cttctgtttg tcagtctcat      480

ataagaacta cagctcatca ggaggagatc gcagcagggt aagagacacc aacaccatgt      540

tctgcacgaa gctcaaggat ctcaagatca caggagagtg tcctttctcc ttactggcac      600

caggtcaagt tcctaacgag tcttcagagg aggcagcagg aagctcagag agctgcaaag      660

caaccgtgcc catctgtcaa gacattcctg agaagaacat acaagaaagt cttcctcaaa      720

gaaaaaccag tcggagccga gtctatcttc acactttggc agagagtatt tgcaaactga      780

ttttcccaga gtttgaacgg ctgaatgttg cacttcagag aacattggca aagcacaaaa      840

taaaagaaag caggaaatct ttggaaagag aagactttga aaaaacaatt gcagagcaag      900

cagttgcagc aggagttcca gtggaggtta tcaaagaatc tcttggtgaa gaggttttta      960

aaatatgtta cgaggaagat gaaaacatcc ttggggtggt tggaggcacc cttaaagatt     1020

ttttaaacag cttcagtacc cttctgaaac agagcagcca ttgccaagaa gcaggaaaaa     1080

ggggcaggct tgaggacgcc tccattctat gcctggataa ggaggatgat tttctacatg     1140

tttactactt cttccctaag agaaccacct ccctgattct tcccggcatc ataaaggcag     1200

ctgctcacgt attatatgaa acggaagtgg aagtgtcgtt aatgcctccc tgcttccata     1260

atgattgcag cgagtttgtg aatcagccct acttgttgta ctccgttcac atgaaaagca     1320

ccaagccatc cctgtccccc agcaaacccc agtcctcgct ggtgattccc acatcgctat     1380

tctgcaagac atttccattc catttcatgt ttgacaaaga tatgacaatt ctgcaatttg     1440

gcaatggcat cagaaggctg atgaacagga gagactttca aggaaagcct aattttgaag     1500

aatactttga aattctgact ccaaaaatca accagacgtt tagcgggatc atgactatgt     1560

tgaatatgca gtttgttgta cgagtgagga gatgggacaa ctctgtgaaa aaatcttcaa     1620

gggttatgga cctcaaaggc caaatgatct acattgttga atccagtgca atcttgtttt     1680

tggggtcacc ctgtgtggac agattagaag attttacagg acgagggctc tacctctcag     1740

acatcccaat tcacaatgca ctgagggatg tggtcttaat aggggaacaa gcccgagctc     1800

aagatggcct gaagaagagg ctggggaagc tgaaggctac ccttgagcaa gcccaccaag     1860

ccctggagga ggagaagaaa aagacagtag accttctgtg ctccatattt ccctgtgagg     1920

ttgctcagca gctgtggcaa gggcaagttg tgcaagccaa gaagttcagt aatgtcacca     1980

tgctcttctc agacatcgtt gggttcactg ccatctgctc ccagtgctca ccgctgcagg     2040

tcatcaccat gctcaatgca ctgtacactc gcttcgacca gcagtgtgga gagctggatg     2100

tctacaaggt ggagaccatt ggcgatgcct attgtgtagc tgggggatta cacaaagaga     2160

gtgatactca tgctgttcag atagcgctga tggccctgaa gatgatggag ctctctgatg     2220

aagttatgtc tccccatgga gaacctatca agatgcgaat tggactgcac tctggatcag     2280

tttttgctgg cgtcgttgga gttaaaatgc cccgttactg tctttttgga aacaatgtca     2340

ctctggctaa caaatttgag tcctgcagtg taccacgaaa aatcaatgtc agcccaacaa     2400

cttacagatt actcaaagac tgtcctggtt tcgtgtttac ccctcgatca agggaggaac     2460

ttccaccaaa cttccctagt gaaatccccg gaatctgcca ttttctggat gcttaccaac     2520

aaggaacaaa ctcaaaacca tgcttccaaa agaaagatgt ggaagatggc aatgccaatt     2580

ttttaggcaa agcatcagga atagattagc aacctatata cctatttata agtctttggg     2640

gtttgactca ttgaagatgt gtagagcctc tgaaagcact ttagggattg tagatggcta     2700

acaagcagta ttaaaatttc aggagccaag tcacaatctt tctcctgttt aacatgacaa     2760

aatgtatgta ctcacttcag tacttcagct cttcaagaaa aaaaaaaaaa accttaaaaa     2820

gctacttttg tgggagtatt tctattatat aaccagcact tactacctgt actcaaaatt     2880

cagcaccttg tacatatatc agataattgt agtcaattgt acaaactgat ggagtcacct     2940

gcaatctcat atcctggtgg aatgccatgg ttattaaagt gtgtttgtga tagtgtcgtc     3000

aaaaaaaagg tttttgaata gaaattacat tctttgacac cctcagttct ttcaaacttt     3060

caactctgca ttttattgca ttttctcatt taactgttag tatatgtttg aatataggct     3120

gacttttttt ctctattgca ctttcttctt tttttctttt tagaaaataa gcaattaggg     3180

gttagatgca atatgaatat aaaatagttc tgtaaatacc aaatattatt tttagttctg     3240

gaagttaaaa atactctcca tagtaacgtg tgttataata ataaatattt cttttgtttg     3300

acttttttaa aattctacaa tggtaaaagc tattttaatc catgttagca atttaattcc     3360

tattaattca ttttactatc ataatagcaa agtattcaga ataaaagagg tttatatctt     3420

ctattaaaat gcagtaatac tattcaaatc taatttagct ggaagcaaca tgggagtaaa     3480

gtaatcatcc aggggaccca ccataaagga cattggtaaa acatttacac acgtaaacac     3540

acgtgcaggc acacttggaa caatatggac ccacttcagc agacatcttc tattgccatg     3600

ctgagctgtt taaagtttta agaagaaaat ctaagtatgg aagtagaaaa taagacttgt     3660

tcttttggtg gatatctcat ttttcttgag tatttgtgct gaacattttg gtgtatgtct     3720

atgaactaag aatcaagttt ttgtctcatt aaatatacat atatgaagtg tttttattct     3780

acttgaaata tcttgactta aaaaaaacga ctgttagtat tgatgaagca aatgaggcag     3840

tgactacatt atggaaatgt ctaagtattt tttccggaac ttcaactttt tctttttgtt     3900

ttacataaac atttaagcag ctaggaactt ttagttttag ttaggtcagt tgaagttctc     3960

tggtgaacta aaaaatctac attttggttg gggataaaga tttgatttta aaaacagctt     4020

gaatttaaag caagaaaaag atgaacgtta tagttttaaa atcaatatta gcagagccat     4080

agataggctg agctcttatt tggggttctg agaaataact cagtttaaaa cttctttaac     4140

tgcctccctt agtacccagg ctagcccatg gtgacatcag ggatattcat tactgattgg     4200

cctctagtat tccaagggta ctactataga tattacaatg atgctgttta ctaagtgata     4260

accccgtatc ttacaggact gactttgact caataaacca ctcagcctat tattggaaag     4320

tgccataggc cttgagaaag tatagttaca tcctcacaaa tatatgaagt taagtcacta     4380

cttacaagga aaaaaaatgt aaatacattt ttctttctgg aaccgaactc ttattatggg     4440

gaaataatag aaataaagaa aatgtaaaag catgaaatgg aatgtagtct tgatcaaaca     4500

tttcagcaga cctcaatttg cttacaatct gtactcaaaa agtttataat tcaatcagaa     4560

ttcaaaaagt attttgtgtg tttgtgatgt attagcatat acacaaaaca aatgagggga     4620

atgtatataa tcttggtgaa aagttgtatg ggagtttttt gtacgattcc tgcaactttt     4680

ctataaacgt ggcattatat ctaaataaaa aattaccaaa aaacatattt tcacagtgaa     4740

gttaaatcat ctgtgatagg ttccccagac cagcctacaa aggcccatta aatacagaat     4800

aatttgtgga tcttcaaaga ggatgaacat acatttccat gacagagtcc atacgaaatt     4860

cacaatttag atgctaaaaa atttaaggaa tatctttttt tctctatctt atctgctttg     4920

aagcatagcg attagcgaga aacttttcag atccagacca ctgatggtag ccagagtaga     4980

gaccctggag catagattct taaaataaat aaggggccca agtcagagct ttgaggtatt     5040

gaagatggaa aaatagtgga caaacagcct gtaatcaggt tggggattac gggtactgag     5100

ttatgttgcc atttaactat tctaaaaaat aagactgggt ctcaagactg cttccctaac     5160

agactgtttc tcctgaaaat gcaggagcta ttctttctgt tctggttata tagtttccat     5220

tcatggcttc ttgtcctgtt gttttttgtg tcgagtacac tatataaatt atctccttat     5280

acatatttct caggcaagca cagagttata ctgaactttt ctaaagatgc tttgcatcaa     5340

gaagcaaagg gaaatacaga attaaaatgt ttctttccat tttgctttgt ttttctatat     5400

cgatctagac tttgtaggaa aatgcaaagc gtatatttaa gaaaacctaa ataagaatag     5460

attcatttac tcattttcat ttattcattc atgaagaatt tattgaatgc ctactatgtg     5520

ccaggaatat tgctatattt ttgaaattta aggataaaat atggcccaat ctatcaagaa     5580

aggaaagtga aagacaaatg taagacataa ttacaacatt ctgtgggagc acaaagtagg     5640

ggactcagtt cttagagaag tcttttggtc ttagagttca tcaagcagag aaggggaagg     5700

acatggtcca ggaaaataaa tcagcacaca aagagatggg gtcttgaggg tgcatagtac     5760

attctggaca gccagttacc tgggatgagt tgggagggag gagaataagg acaaaagacc     5820

atctgggcaa aaatcacgaa ggggtatgtg tgtcatgtaa aggtgtgcca tgatagttat     5880

tcatattgct attgtaatat taatatatag taattaacta cacatgacac agctttacat     5940

gaccttaagt agttatcaac attaccataa tagtaatatt aataactaca ataagagcca     6000

ttattattca cttgaggcac ttgttcaaaa tagattttac aaaagaaaaa aaaaaaagaa     6060

gcaacatgag taaaattaga tccattggct actgactccc tctccaacag ttttaaagct     6120

actagataag agaagcatca agtcttaaag gaagagaatg gtatgatcag atgtgtgttt     6180

tccaaagact attagaaaca gcatggttaa ggatagggtg gatatttact tgcacaggtg     6240

actgaatgaa catctgttta tacatcaagg gaaaatgatt cattttatat cctggatatt     6300

ttaccataag tatgagcata aagctgggat gtctggcatt ggaattttat gtcactctca     6360

aggctaatta gtctttcaga tcctttggta gggaggaaag aagagttgct tcagcatttt     6420

gactaacatt tcttccaaat ttcttctccc tgatatttcc agccacgcca aggcaaagac     6480

ttcccagctc tgtctcaggt taggttaaaa gaaggcatag gatggaagag ggtggtctgt     6540

ggtaggccta gcaaatgaaa gagatgaata aacaagagtg tctagtctaa ctagtgcctg     6600

aggaatagac atcagtcctc tgagattacc cagctggaaa actgcccaga tggagcttta     6660

catgcaaagc tccagtgaag tctagtgctg tataatgctt taaatccaca atcaagccct     6720

tgttgatgca aatgttagtc gcccaaagca gaatgggtta acgaattact gcagtggttt     6780

taggtgcatg ggtttgaccc atgtaaatca ttttaataag taaaattgaa tctttgatac     6840

atatttgttg aggagcttgt cagatcacta cctttcactg aacagtaaaa catggatcat     6900

ttatttcacc tcattttgca cttcaatgca atttcactct ttaggtggtt gtacttggac     6960

agttaaatga agactgtctt taagggtgca gggatggaga acacagcata tatgagaggt     7020

gggagggcag agacgccttg cgattcctgt gaggagggac ttaccgtctc ctccaaaaca     7080

gaaattcagt gctgcagaga cggtagcaaa gtgcagttct cttgttaaaa cacaggctaa     7140

aagcagtgac tgcttaactt attaagcaga gaaaaccaaa atgtcatttt caaccaaaat     7200

tgagtgttag agtttatggt ctctgttatg atacttttca agacctggga aatatttgta     7260

tcctttagtg aaaaggggaa gaatcaatta ctgaaagcca taagcttaca gtaacggagc     7320

caattaatcc tttgtcatct ttgttgagtt tagttttctt ctgttcttag cacgtcagct     7380

agtagatctt tgatgaactg ttgctcctct ttaaatgttt cttttattat attgatgatg     7440

tgcactcatt cagtattctt attttaagct gcagtaatca ctgtacattt gattgccatc     7500

tgtacttccc ttgaagcagc tttgcttatt acagccacac ctgcatctgt tttgactagc     7560

ccacataacc tacacatttt tcatccaaag ctatcccatt accttattta tgtccattta     7620

ttttcatata tagtatctgc caaaatagta gcaaaagttt tatcaatgtg tagatttcaa     7680

tcagaaaaac ctaagcaaaa ggaaaaaaaa gtgatattct aaaagccaca cttcttttat     7740

caccagtgca gttttttcca tcatcataaa cttagtttta tgaaaatgtt aatatcttgg     7800

atttaaacat tggggtagaa atcaggacaa aatttaaatg tcatatccag gacttaatct     7860

cagatattct ggtagaagat atttagataa ggttgtggct gcctgtcaag ttttttaatt     7920

ttttaaatta tataatgtca gaaaattaaa tcacaaatga gccttccaga ttgtgaggaa     7980

aattacttgg ctgaaaatga ctttgcataa tgcccaaatc ttgaagtatc tgctcagatg     8040

tttgttccat ctgaaatgct gccaaatcca tctgtattga ggaaagagct atgaggtagt     8100

ttcagagaaa gtgaaaacaa aacaaagcaa aacaaaaatg ctattacaga agttggacag     8160

cccaatgtgt taagtattat acacctggaa caagagcagc aaaactgaag ctctttggaa     8220

agttatggca acagtggtct gggaattctg ggcctttaga aataatcatt cccagtgata     8280

cagggatgtg cagcatccag acactgctta atcacagtga gctgccgtct tccctgaata     8340

agttgtatct tataacattg aagtgaatga aaatgtatta gtatttgaga atttactatt     8400

ccttcacctc cttgcacatg taaattaaag atgttttgga aaatatgaga acttgatgtt     8460

cactgcccta gagcactatt ctccaacctt ttagattcct gcaatctgtt aataaaatat     8520

tgtaggacaa caactctata gactgataca tgctgctctc aatccatata ctacatatta     8580

ggacagcttt tcttttctaa atgagcatga atataaatag aaattctagt attttcttca     8640

cctaccccag tgaatcatct ttatatttta cttgggaaac tgctacagtt ggctagtggg     8700

tcttcacttt tattgctttg agaaatggat aaaagacata gactatcacc cctccaaaaa     8760

tgtgcatatg gccccataca agacacatgt actgccagag cttggggaac tccctagaat     8820

ctactcctag accaccctag tgaagtacca tagaccatat tgtctagatg ggacaaaata     8880

ataaattttg actaagaact tactgtttag agagaaaaaa tagtaaataa tgttcaaaat     8940

gagaagacaa taactgacaa gtctgtgatt tttgggttag atgagaccac ttttgatttt     9000

tgaggaataa aaggagttag ttttttggtc ctgatgtgta aaatgattca tggggtttca     9060

catacagaca agtagttttc ttttcagcaa atatttaaca tatctctcaa tatatttttc     9120

accagttttt ggtaaatatg cattgctata ggtataccaa gttttttttg ttatgtttag     9180

taactaattt cattttttct gtatatgtaa atatagctat tggaccctgc attgaaaacc     9240

ttcttagtac taacaacact ccttttatta ttaccttcat agttacttta aatgacatat     9300

ttatttcgag ttttacttct ggctgagttg caaagtctat gagaatgtta cctcctgtct     9360

cagaagcttg ttagttattg tgccacctaa atattgtaat aaaagtgttt aaataaaaat     9420

cttcttaaaa tttaaaatga aaaaaaaaaa aaaa                                 9454


<210>  332
<211>  690
<212>  PRT
<213>  Homo Sapiens

<400>  332

Met Phe Cys Thr Lys Leu Lys Asp Leu Lys Ile Thr Gly Glu Cys Pro 
1               5                   10                  15      


Phe Ser Leu Leu Ala Pro Gly Gln Val Pro Asn Glu Ser Ser Glu Glu 
            20                  25                  30          


Ala Ala Gly Ser Ser Glu Ser Cys Lys Ala Thr Val Pro Ile Cys Gln 
        35                  40                  45              


Asp Ile Pro Glu Lys Asn Ile Gln Glu Ser Leu Pro Gln Arg Lys Thr 
    50                  55                  60                  


Ser Arg Ser Arg Val Tyr Leu His Thr Leu Ala Glu Ser Ile Cys Lys 
65                  70                  75                  80  


Leu Ile Phe Pro Glu Phe Glu Arg Leu Asn Val Ala Leu Gln Arg Thr 
                85                  90                  95      


Leu Ala Lys His Lys Ile Lys Glu Ser Arg Lys Ser Leu Glu Arg Glu 
            100                 105                 110         


Asp Phe Glu Lys Thr Ile Ala Glu Gln Ala Val Ala Ala Gly Val Pro 
        115                 120                 125             


Val Glu Val Ile Lys Glu Ser Leu Gly Glu Glu Val Phe Lys Ile Cys 
    130                 135                 140                 


Tyr Glu Glu Asp Glu Asn Ile Leu Gly Val Val Gly Gly Thr Leu Lys 
145                 150                 155                 160 


Asp Phe Leu Asn Ser Phe Ser Thr Leu Leu Lys Gln Ser Ser His Cys 
                165                 170                 175     


Gln Glu Ala Gly Lys Arg Gly Arg Leu Glu Asp Ala Ser Ile Leu Cys 
            180                 185                 190         


Leu Asp Lys Glu Asp Asp Phe Leu His Val Tyr Tyr Phe Phe Pro Lys 
        195                 200                 205             


Arg Thr Thr Ser Leu Ile Leu Pro Gly Ile Ile Lys Ala Ala Ala His 
    210                 215                 220                 


Val Leu Tyr Glu Thr Glu Val Glu Val Ser Leu Met Pro Pro Cys Phe 
225                 230                 235                 240 


His Asn Asp Cys Ser Glu Phe Val Asn Gln Pro Tyr Leu Leu Tyr Ser 
                245                 250                 255     


Val His Met Lys Ser Thr Lys Pro Ser Leu Ser Pro Ser Lys Pro Gln 
            260                 265                 270         


Ser Ser Leu Val Ile Pro Thr Ser Leu Phe Cys Lys Thr Phe Pro Phe 
        275                 280                 285             


His Phe Met Phe Asp Lys Asp Met Thr Ile Leu Gln Phe Gly Asn Gly 
    290                 295                 300                 


Ile Arg Arg Leu Met Asn Arg Arg Asp Phe Gln Gly Lys Pro Asn Phe 
305                 310                 315                 320 


Glu Glu Tyr Phe Glu Ile Leu Thr Pro Lys Ile Asn Gln Thr Phe Ser 
                325                 330                 335     


Gly Ile Met Thr Met Leu Asn Met Gln Phe Val Val Arg Val Arg Arg 
            340                 345                 350         


Trp Asp Asn Ser Val Lys Lys Ser Ser Arg Val Met Asp Leu Lys Gly 
        355                 360                 365             


Gln Met Ile Tyr Ile Val Glu Ser Ser Ala Ile Leu Phe Leu Gly Ser 
    370                 375                 380                 


Pro Cys Val Asp Arg Leu Glu Asp Phe Thr Gly Arg Gly Leu Tyr Leu 
385                 390                 395                 400 


Ser Asp Ile Pro Ile His Asn Ala Leu Arg Asp Val Val Leu Ile Gly 
                405                 410                 415     


Glu Gln Ala Arg Ala Gln Asp Gly Leu Lys Lys Arg Leu Gly Lys Leu 
            420                 425                 430         


Lys Ala Thr Leu Glu Gln Ala His Gln Ala Leu Glu Glu Glu Lys Lys 
        435                 440                 445             


Lys Thr Val Asp Leu Leu Cys Ser Ile Phe Pro Cys Glu Val Ala Gln 
    450                 455                 460                 


Gln Leu Trp Gln Gly Gln Val Val Gln Ala Lys Lys Phe Ser Asn Val 
465                 470                 475                 480 


Thr Met Leu Phe Ser Asp Ile Val Gly Phe Thr Ala Ile Cys Ser Gln 
                485                 490                 495     


Cys Ser Pro Leu Gln Val Ile Thr Met Leu Asn Ala Leu Tyr Thr Arg 
            500                 505                 510         


Phe Asp Gln Gln Cys Gly Glu Leu Asp Val Tyr Lys Val Glu Thr Ile 
        515                 520                 525             


Gly Asp Ala Tyr Cys Val Ala Gly Gly Leu His Lys Glu Ser Asp Thr 
    530                 535                 540                 


His Ala Val Gln Ile Ala Leu Met Ala Leu Lys Met Met Glu Leu Ser 
545                 550                 555                 560 


Asp Glu Val Met Ser Pro His Gly Glu Pro Ile Lys Met Arg Ile Gly 
                565                 570                 575     


Leu His Ser Gly Ser Val Phe Ala Gly Val Val Gly Val Lys Met Pro 
            580                 585                 590         


Arg Tyr Cys Leu Phe Gly Asn Asn Val Thr Leu Ala Asn Lys Phe Glu 
        595                 600                 605             


Ser Cys Ser Val Pro Arg Lys Ile Asn Val Ser Pro Thr Thr Tyr Arg 
    610                 615                 620                 


Leu Leu Lys Asp Cys Pro Gly Phe Val Phe Thr Pro Arg Ser Arg Glu 
625                 630                 635                 640 


Glu Leu Pro Pro Asn Phe Pro Ser Glu Ile Pro Gly Ile Cys His Phe 
                645                 650                 655     


Leu Asp Ala Tyr Gln Gln Gly Thr Asn Ser Lys Pro Cys Phe Gln Lys 
            660                 665                 670         


Lys Asp Val Glu Asp Gly Asn Ala Asn Phe Leu Gly Lys Ala Ser Gly 
        675                 680                 685             


Ile Asp 
    690 


<210>  333
<211>  3859
<212>  DNA
<213>  Homo Sapiens

<400>  333
ctaggcggcg gcggccgggt ccccaaggct gggcgctgct tgcggaaccg acggggcgga       60

gaggagcgtg gcgggaggag gagtaggaga agggggctgg tcaagggaag tgcgacgtgt      120

ctgcggagcc tttttatacc tccttcccgg gagtccggca gccgctgctg ctgctgctgc      180

tgctgctgcc gccgccgccg ccgccgtccc tgcgtccttc ggtctctgct cccgggaccc      240

gggctccgcc gcagccagcc agcatgtcgg ggatcaagaa gcaaaagacg gagaaccagc      300

agaaatccac caatgtagtc tatcaggccc accatgtgag caggaataag agagggcaag      360

tggttggaac aaggggtggg ttccgaggat gtaccgtgtg gctaacaggt ctctctggtg      420

ctggaaaaac aacgataagt tttgccctgg aggagtacct tgtctcccat gccatccctt      480

gttactccct ggatggggac aatgtccgtc atggccttaa cagaaatctc ggattctctc      540

ctggggacag agaggaaaat atccgccgga ttgctgaggt ggctaagctg tttgctgatg      600

ctggtctggt ctgcattacc agctttattt ctccattcgc aaaggatcgt gagaatgccc      660

gcaaaataca tgaatcagca gggctgccat tctttgaaat atttgtagat gcacctctaa      720

atatttgtga aagcagagac gtaaaaggcc tctataaaag ggccagagct ggggagatta      780

aaggatttac aggtattgat tctgattatg agaaacctga aactcctgag cgtgtgctta      840

aaaccaattt gtccacagtg agtgactgtg tccaccaggt agtggaactt ctgcaagagc      900

agaacattgt accctatact ataatcaaag atatccacga actctttgtg ccggaaaaca      960

aacttgacca cgtccgagct gaggctgaaa ctctcccttc attatcaatt actaagctgg     1020

atctccagtg ggtccaggtt ttgagcgaag gctgggccac tcccctcaaa ggtttcatgc     1080

gggagaagga gtacttacag gttatgcact ttgacaccct gctagatgat ggcgtgatca     1140

acatgagcat ccccattgta ctgcccgtct ctgcagagga taagacacgg ctggaagggt     1200

gcagcaagtt tgtcctggca catggtggac ggagggtagc tatcttacga gacgctgaat     1260

tctatgaaca cagaaaagag gaacgctgtt cccgtgtttg ggggacaaca tgtacaaaac     1320

acccccatat caaaatggtg atggaaagtg gggactggct ggttggtgga gaccttcagg     1380

tgctggagaa aataagatgg aatgatgggc tggaccaata ccgtctgaca cctctggagc     1440

tcaaacagaa atgtaaagaa atgaatgctg atgcggtgtt tgcattccag ttgcgcaatc     1500

ctgtccacaa tggccatgcc ctgttgatgc aggacactcg ccgcaggctc ctagagaggg     1560

gctacaagca cccggtcctc ctactacacc ctctgggcgg ctggaccaag gatgacgatg     1620

tgcctctaga ctggcggatg aagcagcacg cggctgtgct cgaggaaggg gtcctggatc     1680

ccaagtcaac cattgttgcc atctttccgt ctcccatgtt atatgctggc cccacagagg     1740

tccagtggca ctgcaggtcc cggatgattg cgggtgccaa tttctacatt gtggggaggg     1800

accctgcagg aatgccccat cctgaaacca agaaggatct gtatgaaccc actcatgggg     1860

gcaaggtctt gagcatggcc cctggcctca cctctgtgga aatcattcca ttccgagtgg     1920

ctgcctacaa caaagccaaa aaagccatgg acttctatga tccagcaagg cacaatgagt     1980

ttgacttcat ctcaggaact cgaatgagga agctcgcccg ggaaggagag aatcccccag     2040

atggcttcat ggcccccaaa gcatggaagg tcctgacaga ttattacagg tccctggaga     2100

agaactaagc ctttggctcc agagtttctt tctgaagtgc tctttgatta ccttttctat     2160

ttttatgatt agatgctttg tattaaattg cttctcaatg atgcatttta atcttttata     2220

atgaagtaaa agttgtgtct ataattaaaa aaaaatatat atatatacac acacacatat     2280

acatacaaag tcaaactgaa gaccaaatct tagcaggtaa aagcaatatt cttatacatt     2340

tcataataaa attagctcta tgtattttct actgcacctg agcaggcagg tcccagattt     2400

cttaaggctt tgtttgacca tgtgtctagt tacttgctga aaagtgaata tattttccag     2460

catgtcttga caacctgtac tcttccaatg tcatttatca gttgtaaaat atatcagatt     2520

gtgtcctctt ctgtacaatt gacaaaaaaa aaaatttttt tttctcactc taaaagaggt     2580

gtggctcaca tcaagattct tcctgatatt ttacctcatg ctgtacaaag ccttaatgtt     2640

gtaatcatat cttacgtgtt gaagacctga ctggagaaac aaaatgtgca ataacgtgaa     2700

ttttatctta gagatctgtg cagcctattt ctgtcacaaa agttatattg tctaataaga     2760

gaagtcttaa tggcctctgt gaataatgta actccagtta cacggtgact tttaatagca     2820

tacagtgatt tgatgaaagg acgtcaaaca atgtggcgat gtcgtggaaa gttatctttc     2880

ccgctctttg ctgtggtcat tgtgtcttgc agaaaggatg gccctgatgc agcagcagcg     2940

ccagctgtaa taaaaaataa ttcacactat cagactagca aggcactaga actggaaaag     3000

accacagaaa acaaagaatc caaccctttc atcttacagg tgaacaaact gtgatgatgc     3060

acatgtatgt gttttgtaag ctgtgagcac cgtaacaaaa tgtaaatttg ccattattag     3120

gaagtgctgg tggcagtgaa gaagcaccca ggccacttga ctcccagtct ggtgccctgt     3180

ctacaccaga caacacagga gctgggtcag attcccctca gctgcttaac aaagttcctc     3240

gaacagaaag tgcttacaaa gctgccttct cggatactga aaggtcgagt tttctgaact     3300

gcactgattt tattgcagtt gaaaaaaaaa aaaagctatt ccaaagattt caagctgttc     3360

tgagacatct tctgatggct ttacttcctg agaggcaatg tttttacttt atgcataatt     3420

cattgttgcc aaggaataaa gtgaagaaac agcacctttt aatatatagg tctctctgga     3480

agagacctaa attagaaaga gaaaactgtg acaattttca tattctcatt cttaaaaaac     3540

actaatctta actaacaaaa gttcttttga gaataagtta cacacaatgg ccacagcagt     3600

ttgtctttaa tagtatagtg cctatactca tgtaatcggt tactcactac tgcctttaaa     3660

aaaaaaaacc agcatattta ttgaaaacat gagacaggat tatagtgcct taaccgatat     3720

attttgtgac ttaaaaaata catttaaaac tgctcttctg ctctagtacc atgcttagtg     3780

caaatgatta tttctatgta caactgatgc ttgttcttat tttaataaat ttatcagagt     3840

gaaaaaaaaa aaaaaaaaa                                                  3859


<210>  334
<211>  614
<212>  PRT
<213>  Homo Sapiens

<400>  334

Met Ser Gly Ile Lys Lys Gln Lys Thr Glu Asn Gln Gln Lys Ser Thr 
1               5                   10                  15      


Asn Val Val Tyr Gln Ala His His Val Ser Arg Asn Lys Arg Gly Gln 
            20                  25                  30          


Val Val Gly Thr Arg Gly Gly Phe Arg Gly Cys Thr Val Trp Leu Thr 
        35                  40                  45              


Gly Leu Ser Gly Ala Gly Lys Thr Thr Ile Ser Phe Ala Leu Glu Glu 
    50                  55                  60                  


Tyr Leu Val Ser His Ala Ile Pro Cys Tyr Ser Leu Asp Gly Asp Asn 
65                  70                  75                  80  


Val Arg His Gly Leu Asn Arg Asn Leu Gly Phe Ser Pro Gly Asp Arg 
                85                  90                  95      


Glu Glu Asn Ile Arg Arg Ile Ala Glu Val Ala Lys Leu Phe Ala Asp 
            100                 105                 110         


Ala Gly Leu Val Cys Ile Thr Ser Phe Ile Ser Pro Phe Ala Lys Asp 
        115                 120                 125             


Arg Glu Asn Ala Arg Lys Ile His Glu Ser Ala Gly Leu Pro Phe Phe 
    130                 135                 140                 


Glu Ile Phe Val Asp Ala Pro Leu Asn Ile Cys Glu Ser Arg Asp Val 
145                 150                 155                 160 


Lys Gly Leu Tyr Lys Arg Ala Arg Ala Gly Glu Ile Lys Gly Phe Thr 
                165                 170                 175     


Gly Ile Asp Ser Asp Tyr Glu Lys Pro Glu Thr Pro Glu Arg Val Leu 
            180                 185                 190         


Lys Thr Asn Leu Ser Thr Val Ser Asp Cys Val His Gln Val Val Glu 
        195                 200                 205             


Leu Leu Gln Glu Gln Asn Ile Val Pro Tyr Thr Ile Ile Lys Asp Ile 
    210                 215                 220                 


His Glu Leu Phe Val Pro Glu Asn Lys Leu Asp His Val Arg Ala Glu 
225                 230                 235                 240 


Ala Glu Thr Leu Pro Ser Leu Ser Ile Thr Lys Leu Asp Leu Gln Trp 
                245                 250                 255     


Val Gln Val Leu Ser Glu Gly Trp Ala Thr Pro Leu Lys Gly Phe Met 
            260                 265                 270         


Arg Glu Lys Glu Tyr Leu Gln Val Met His Phe Asp Thr Leu Leu Asp 
        275                 280                 285             


Asp Gly Val Ile Asn Met Ser Ile Pro Ile Val Leu Pro Val Ser Ala 
    290                 295                 300                 


Glu Asp Lys Thr Arg Leu Glu Gly Cys Ser Lys Phe Val Leu Ala His 
305                 310                 315                 320 


Gly Gly Arg Arg Val Ala Ile Leu Arg Asp Ala Glu Phe Tyr Glu His 
                325                 330                 335     


Arg Lys Glu Glu Arg Cys Ser Arg Val Trp Gly Thr Thr Cys Thr Lys 
            340                 345                 350         


His Pro His Ile Lys Met Val Met Glu Ser Gly Asp Trp Leu Val Gly 
        355                 360                 365             


Gly Asp Leu Gln Val Leu Glu Lys Ile Arg Trp Asn Asp Gly Leu Asp 
    370                 375                 380                 


Gln Tyr Arg Leu Thr Pro Leu Glu Leu Lys Gln Lys Cys Lys Glu Met 
385                 390                 395                 400 


Asn Ala Asp Ala Val Phe Ala Phe Gln Leu Arg Asn Pro Val His Asn 
                405                 410                 415     


Gly His Ala Leu Leu Met Gln Asp Thr Arg Arg Arg Leu Leu Glu Arg 
            420                 425                 430         


Gly Tyr Lys His Pro Val Leu Leu Leu His Pro Leu Gly Gly Trp Thr 
        435                 440                 445             


Lys Asp Asp Asp Val Pro Leu Asp Trp Arg Met Lys Gln His Ala Ala 
    450                 455                 460                 


Val Leu Glu Glu Gly Val Leu Asp Pro Lys Ser Thr Ile Val Ala Ile 
465                 470                 475                 480 


Phe Pro Ser Pro Met Leu Tyr Ala Gly Pro Thr Glu Val Gln Trp His 
                485                 490                 495     


Cys Arg Ser Arg Met Ile Ala Gly Ala Asn Phe Tyr Ile Val Gly Arg 
            500                 505                 510         


Asp Pro Ala Gly Met Pro His Pro Glu Thr Lys Lys Asp Leu Tyr Glu 
        515                 520                 525             


Pro Thr His Gly Gly Lys Val Leu Ser Met Ala Pro Gly Leu Thr Ser 
    530                 535                 540                 


Val Glu Ile Ile Pro Phe Arg Val Ala Ala Tyr Asn Lys Ala Lys Lys 
545                 550                 555                 560 


Ala Met Asp Phe Tyr Asp Pro Ala Arg His Asn Glu Phe Asp Phe Ile 
                565                 570                 575     


Ser Gly Thr Arg Met Arg Lys Leu Ala Arg Glu Gly Glu Asn Pro Pro 
            580                 585                 590         


Asp Gly Phe Met Ala Pro Lys Ala Trp Lys Val Leu Thr Asp Tyr Tyr 
        595                 600                 605             


Arg Ser Leu Glu Lys Asn 
    610                 


<210>  335
<211>  5561
<212>  DNA
<213>  Homo Sapiens

<400>  335
agggggccga ctggcgcggc tctggagagc gctcctccgc cccgcgcgcc gtccctgcgc       60

cccgctccgc ccgcgcctct ctcccagcgc cgcgcctcgg gcgtaaagag cgcgcccctc      120

gcaccgcagc cagtgccgac cgcagcagcc cagccccagc cttcctccgc ctccgcctct      180

ctctcctcct cctcctccgc cgccggacac gcagccgcag gccgggaccg ggacgcagct      240

ggggagtcag ggacgcgcgc agccagccct tccccctccg gctcccgcac cgccggccgc      300

ctcccctcgc cctcctactc tcccctccct gctccttcgc tttttcctcc tcctcctctc      360

ccggccccgg ctgccagcac catgtccgca gggggagatt ttgggaatcc actgagaaaa      420

ttcaagttgg tgttcttggg ggagcagagc gtcgggaaga cgtctctgat tacgaggttc      480

atgtacgaca gcttcgacaa cacataccag gcaaccattg ggattgactt cttgtcaaaa      540

accatgtact tggaggaccg cacggtgcga ctgcagctct gggacacagc tggtcaggag      600

aggttccgca gcctgatccc cagctacatc cgggactcca cggtggctgt ggtggtgtac      660

gacatcacaa atctcaactc cttccaacag acctctaagt ggatcgacga cgtcaggaca      720

gagaggggca gtgatgttat catcatgctg gtgggcaaca agacggacct ggctgataag      780

aggcagataa ccatcgagga gggggagcag cgcgccaaag aactgagcgt catgttcatt      840

gagaccagtg cgaagactgg ctacaacgtg aagcagcttt ttcgacgtgt ggcgtcggct      900

ctacccggaa tggagaatgt ccaggagaaa agcaaagaag ggatgatcga catcaagctg      960

gacaaacccc aggagccccc ggccagcgag ggcggctgct cctgctaatg cagagccgac     1020

ctgtggcttc ccatgacact ccttgcttgt tgtgttgctt cctattggct agcttcctaa     1080

ggggggaggg aaccgagtta tcaagatggg aggatttttc ttttctctct gtctttagga     1140

gtagggtggg atggggaggg aggctgggca tcagggatca catcactctt aacggctgtt     1200

acttaaacaa ctattttttg gtttggttgt aatatattgt actttattaa gattgccaaa     1260

aactgttaaa atttaaaaaa aatttaaatc atgtgtatac aattttttgc cagataaaaa     1320

tgtagtcatt tttatttgaa agatgtgctt tttgtttttg tatatttgta aacttataga     1380

gaaccttttc cacacacctc ctccttcctg ttctctttga accattcatc acctctgcct     1440

tcctcctatc cccagcccaa taaattaaaa caattaactg agcaaattaa ttaggcttca     1500

gtctggggcc atctggcccc actctctagg ccctactcca gttaaatcaa acattggttg     1560

aacacatcag cctctgaaaa ggtagctctg actcttgtct ttccatggcc agagtgggtc     1620

gtcaacctcg tgtggagctg agaccaaggt ctgtgggctc taggcagccc ggcagcagcc     1680

cccagaggaa ctgctcccac ctctccttct ctttccctga aaagccttga agggggttga     1740

gggtacaggc aaccttgtgt tctctgtgcc ctcagggact ggcagagcaa gaggccatca     1800

gaaggacgag gtgctgttgg caattgcagc tgcgtggtgc gtggtttata gactggggtg     1860

ccatgtgtac ttctgaaaat attttaacca gcccacccag cagtcagtac acatgcctgg     1920

gccaagtcta agaaactcag tgtgtgatgt tgggcagtgt gccatcctga agccttcctc     1980

ctggatgtca gggaagctgg accacctgga gttgatcctc tgtgatgggg aggcgggggg     2040

gggggggggt gttgtctgca gaaccaccac cttgaaagat ccatgttctt agagcctcag     2100

ctgctaatat tgttgagtgc tttctggaaa agctgatttg ttgctatgtt ttcaccccag     2160

tggcatggcg cagttgaagt ctttgtggac atatctttgt ggctactgtg gctgcgctgt     2220

ggtcacctga ggatgtggtt caggtggggt ctccagaagg ctgcttgccc ccagagagcc     2280

atctcttcca tttttgattc attcctgaga atggcttagt cctgagaatc tgcaaagtct     2340

ctgaagagaa ctctctcttc ccactaagtg atataaccta cttggccagc attccaaata     2400

gactcagact cactgccctg agcctgcaca gagccaggtg caatgggcag tgagtctggc     2460

caaaatgtaa accccaccct ccctgctgtc attggctctc cctccaggct gctgctgggc     2520

atgtcataga tgggatgaat gaccatctgg ggtatggtgg gctgaactcc acaaggtcgt     2580

tggaatgaat tttgaaactt ctcagaaatt aatctgaaat ggcaggcagt aagtgcagca     2640

gaatctggca ggactgatat ttgtgcagtg ggcctgccac acaccctctg cctaggaggc     2700

tgtatgccag agctcatctc tagcaaggaa tttatcttca ggtgaagaag agaggaagca     2760

ggatcccact gagcacctct tgcagaaggc aaggaccaat gtttgaacgt gtttcagatg     2820

tcatgtgttt agtttttata tgtgtgtaca taattatata tagagataga cttgtgtata     2880

caccttccac aaacacatcc tcacggagat acatgtgctc aatgtatatt cttgtttctc     2940

ctgctctcaa gttggaactt gcattgtgat aagttttgga aattcaaaag tactgcaacg     3000

tgttgaaata agaaatactt aatattgtca aataacttgt gattgtcttg ccatcaataa     3060

aataatgcat agttgtgtta aactacaggc aaacatagcc cacgggaata tctccaccat     3120

ttctctatgt actttatatg cacgggtgtg catgcctgtg tgggccagtg tccccccacc     3180

atgggcacac ccccaagtgg tgcttgttgg aagagtgctt acttacctcg agagaattta     3240

caggagtcca catgacagtg tcctgcctgg ttggcagcgg gggccatcac ctgtggcctc     3300

tgagaccgcc ccatttacag gaatctgcac tgggtctcag tgaatgaacg tatggtagat     3360

ttttattttc ttggcactaa agattagctt ttttaaaaaa acatcccata aaacagtaga     3420

aactcagttc ccttctcagg ggcacacaca tccaaggcac cgtggactgt gtttccatcc     3480

tggcctagag gagcagtaaa agatagcatt tggtttgaca tggccttagt gagtcctgcc     3540

tttcctagca tgcacacaac atcctctctt tgagtttggg ttctccccag ccccttggcc     3600

tctgaggctg agggtggctt cctcccatcc tcccatctca gtggttccat ggcgctccct     3660

tcggcacgtg cggtttccgc ccctcccttc ctggggtgtg gaaaggcagc cagacctctt     3720

tttcagaagt tgttggttcc ctgatttttg tcttgagcag gcaccatccc tgtccccttg     3780

cttgcaggta gaattggcac agagttaagg ttccataata aactgttagg tgctcttgaa     3840

gaagatgtca tggcattgcc tcagcacccc agcaagagca ttgcatcttt gctgaatcca     3900

gatgggttag cagagggcaa attggaggat tcctttgagg aaatgttctc aattgagcaa     3960

ttcagtccct ctccccaaag actagacgtg acctggcaga ttagcaggat cctcttggcc     4020

ttcttttttg gggatggtgg gagtgaaggg ggtgaatctt aaaagcttat caacaaagct     4080

cctgttctgc aggcatcagg aaagttgagt gtaagatgga aaaagcaaac agcctattta     4140

caagtggaaa cacattggtt ctgatcactc ctaacttgct gggtgatcat acatacatca     4200

acatgaaggt gtgacatcag aatcatgagc accatggctg cagttgtgtg atccaaggct     4260

agttggcttg gtagctgttg gcagcagttt cccttggtca gaggcctcct tgctatctat     4320

cgctgctctc ttcttgtcat ccttaaacat tcagtcatgt tcccaggtct gaggggagca     4380

atggccagac cagtttcagt atctctggca acagaaacaa ggattgaaat ggtggtagtt     4440

aagagtgcag acacatctgg ggtgcaacgt ctgcatcatc ctggtggcta gccagtgcgg     4500

ggaggccctg ccctgggata ccagttgtga caataaaggg atggccctcc tggcttcagc     4560

atcctgcagg tagagcagcc tcattccttc acaagatgga aggcaggtga ggatgtcagg     4620

atgagatggg accaggtagc cgaggacagt gaggcatgtc tgagccactt gaggggcagc     4680

tgaacagaag gatgtctgtg tgcatcaacc gagcagattg tgcgcacact cgtttccgaa     4740

ctgcctctcc ccaaagaatg tgaggcattg tcaccttgtt acagctatgt gaagcagagc     4800

tgtcacaact tttcctgtct acaggcagga aaaccaggat ggagaagggc aacttgctta     4860

ttaagatcac ccagcaagtt aggagtgatc agaaccagtg aagtttccat ttttcatcca     4920

ttgctgccct gtgtgtgaac aaatgtgact ccatatttat tacacagcaa ggactgctgt     4980

gtgtgggtgt gttcctcaga ccatctctac tctttttggt taggacacta ggttcttccc     5040

agcatatgag tgagaatatt ggtggtattt tgggctcctc tactgcacaa gggccagtcc     5100

ccaagtctac tctgattgat tgtcatgggc acccacacag atcaggacac cctttgaatt     5160

tttgtttgac atgaactatt taggtgttcc aaaaccttgg gatctcaatg tgcaaactcc     5220

ttggactcca gacccctgtc tggttggcac tcccagcagt gtgtggtttc atcaggaaat     5280

ccttgcagca ggggtttaga tggttccttc aggaggtggg aagcctccat agcattgaag     5340

gccagcctgc atctcgcggt gtgtgtccac ttctcccctc actttcccct cacccatccc     5400

tttaaagtga ttggctgtga ggagcacaga gggtggcaat tccatctgtt atgggctcag     5460

aagacatagc cgccatgttg atttcacatt aaactgtgta aaatgtggaa aagactcagc     5520

atgttggtca aacaataaac tgtcctaatt ctcaaaacaa a                         5561


<210>  336
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  336

Met Ser Ala Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu 
1               5                   10                  15      


Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg 
            20                  25                  30          


Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile 
        35                  40                  45              


Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Val Arg Leu 
    50                  55                  60                  


Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro 
65                  70                  75                  80  


Ser Tyr Ile Arg Asp Ser Thr Val Ala Val Val Val Tyr Asp Ile Thr 
                85                  90                  95      


Asn Leu Asn Ser Phe Gln Gln Thr Ser Lys Trp Ile Asp Asp Val Arg 
            100                 105                 110         


Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr 
        115                 120                 125             


Asp Leu Ala Asp Lys Arg Gln Ile Thr Ile Glu Glu Gly Glu Gln Arg 
    130                 135                 140                 


Ala Lys Glu Leu Ser Val Met Phe Ile Glu Thr Ser Ala Lys Thr Gly 
145                 150                 155                 160 


Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ser Ala Leu Pro Gly 
                165                 170                 175     


Met Glu Asn Val Gln Glu Lys Ser Lys Glu Gly Met Ile Asp Ile Lys 
            180                 185                 190         


Leu Asp Lys Pro Gln Glu Pro Pro Ala Ser Glu Gly Gly Cys Ser Cys 
        195                 200                 205             


<210>  337
<211>  8487
<212>  DNA
<213>  Homo Sapiens

<400>  337
ccttcggccc cggcggggct ctggcgtacc caaaatgcag gccccagcgg aacgcacagc       60

cctcctgtcc tccgccggtg cccctttagc cgccccaccc ccatccctaa gggctctcat      120

tctccagctg cagccgcagc tgggttccga acacgccgcc gggccccggg agggagaggg      180

gcaggtgcca gggcggcgcg cagcctctgc tcccggtgcc agcttcagtg cgccgggcac      240

acgcgcgccc cgcaacccct ccctcaccct ttccccgttg ctcaatctcc gccagccgcg      300

gtcgctgcat cgtcagagag ctgcaagagg gaggcagcaa ggtgcggccg ccagcagtga      360

caccatgtga ccggcacggc tcactgacac gcagctttgg ttaaagagcg ggcgcacagg      420

aggggaggag accgcgcgcg ggacggggag gaatggcctg tccgcgttaa accatcacaa      480

gccatggttg cggaagggcc acgcgtcccc cagtaggaga atgactccga ttcgtgaccc      540

tcagcgccgg tgcatgtcga tgtaagtgcg aggccggcga gcagagtgtg agtgggggtt      600

ggtggtgagg ggagattctg atgcaatcgg cccggaaagg aggagagcca ggcgagcgcg      660

gactggggcg gccacgccac tccgccagaa ggtcgccagg agcctccgcc cttcaccttc      720

ctccgaaatc cgccaggcca cgccaagctc cctgcccaac ccttactgac gggggccaca      780

ttttcccggc ctccgcagcc agaccttgac acaaaggaca tcaaactgcc gagggtaaaa      840

accccggaag ggcggacacc tccacatcgc cttttgccac ctttcccttt atttccggag      900

atatttattg agtgtctact gtgtgccagg cactatatct atgtgcatag aaaaaccctg      960

gaaggccata caacaatata tatagagtga tcgtctctgc ttgctgagct aacaggggtg     1020

tcaagcttcc attttggtat ctacttctaa atacactcag aacaggagaa atttggacta     1080

attttcaaac tacagacact ttctaatcat gatgcatttc aaaagtggac tcgaattaac     1140

tgagttgcaa aacatgacag tgcccgagga tgataacatt agcaatgact ccaatgattt     1200

caccgaagta gaaaatggtc agataaatag caagtttatt tctgatcgtg aaagtagaag     1260

aagtctcaca aacagccatt tggaaaaaaa gaagtgtgat gagtatattc caggtacaac     1320

ctccttaggc atgtctgttt ttaacctaag caacgccatt atgggcagtg ggattttggg     1380

actcgccttt gccctggcaa acactggaat cctacttttt ctggtacttt tgacttcagt     1440

gacattgctg tctatatatt caataaacct cctattgatc tgttcaaaag aaacaggctg     1500

catggtgtat gaaaagctgg gggaacaagt ctttggcacc acagggaagt tcgtaatctt     1560

tggagccacc tctctacaga acactggagc aatgctgagc tacctcttca tcgtaaaaaa     1620

tgaactaccc tctgccataa agtttctaat gggaaaggaa gagacatttt cagcctggta     1680

cgtggatggc cgcgttctgg tggtgatagt tacctttggc ataattctcc ctctgtgtct     1740

cttgaagaac ttagggtatc ttggctatac tagtggattt tccttgagct gtatggtttt     1800

tttcctaatt gtggttattt acaagaaatt tcaaattccc tgcattgttc cagagctaaa     1860

ttcaacaata agtgctaatt caacaaatgc tgacacgtgt acgccaaaat atgttacctt     1920

caattcaaag accgtgtatg ctttacccac cattgcattt gcatttgttt gccacccgtc     1980

agtcctgcca atttacagtg agcttaaaga ccgatcacag aaaaaaatgc agatggtttc     2040

aaacatctcc tttttcgcca tgtttgttat gtacttcttg actgccattt ttggctactt     2100

gacattctat gacaacgtgc agtccgacct ccttcacaaa tatcagagta aagatgacat     2160

tctcatcctg acagtgcggc tggctgtcat tgttgctgtg atcctcacag tgccggtgtt     2220

atttttcacg gttcgttcat ctttatttga actggctaag aaaacaaagt ttaatttatg     2280

tcgtcatacc gtggttacct gcatactctt ggttgttatc aacttgttgg tgatcttcat     2340

accctccatg aaggatattt ttggagtcgt aggagttaca tctgctaaca tgcttatttt     2400

cattcttcct tcatctcttt atttaaaaat cacagaccag gatggagata aaggaactca     2460

aagaatttgg gctgcccttt tcttgggcct gggggtgttg ttctccttgg tcagcattcc     2520

cttggtcatc tatgactggg cctgctcatc gagtagtgac gaaggccact gaaacccgcc     2580

gagaaaaaga aacatccctg ttgtctgctc agtcaagtcc ccacacatca gcaatctctc     2640

accacttctt ttgcaagttt acagaagcaa acagaaatgt acaggatact taaaatggaa     2700

taactttttg gttgcaaaac agagacatgg ttctataatg cttcatgtcc ctccaagatt     2760

tgagatcaat ttagggattg tgaaattttt ttttcaaatt tcatacaatc atatttccca     2820

gtacttttca caatcatttt ttacccatct aactctatgt tttgtggctt cccggtctct     2880

tagaactttg aaaacatgat atacaataat gtttatttat tatacatcca gattctgaaa     2940

taattttcct actgatgttc agctcacact atctgtacct ttttagaaga gaaaagaatc     3000

ttgaattgta tatatttatt ttgctttaca gaaaaaaatg gtttcgtaaa taatttgcct     3060

attttggtta acatagcaca tggagataat catctgaaag ttatagggca ctgccactgc     3120

tgaatcagag catgcccaat atttgaggtg gctctgattt cctggcagct gaactcgggt     3180

agtccagtgg cctagctggt accacatcta ttcccatcca gagacattct ctggcaagtg     3240

ttctcagctg aaaagtggtt ggggatgatt cttaccttgg taattaaatg aagctacaca     3300

tttgggtaat ctagcaaatg aagtattttt tccctcttgg caacttgtgt cagagttact     3360

ctggtctgag tcaactttcg ctggggaaaa cctatggaac ctactgcaaa aagattgtcc     3420

aaaatgccta agaaaatact cctctgatgc atttagcctt caaccctacc tgtcttgctg     3480

aagggagaaa aatgttttag tacattatag gcccagcagc ttttattcat gtccaccagc     3540

tagttgcaca gagaatcatg tgtacctaac taaggatgat ctaggataag taactcctgt     3600

tttatattga gtattttagg gaagtcttta aaagacttgt tttatatcta taaatctagg     3660

ttattacaaa tacaagaatt ttgtacctta aataagcctc atttctattt cttcttcatt     3720

aattctccat ctagtcttgt gaaaaaaaaa aaaaaaaaac cctcagagat agtctttgtg     3780

aagagcttct gacagaatca ctgagtacct tccttccccc agatgaggaa gacaaggggg     3840

tctcagtgtc tgtgctgtct cctcttctct tccccaacca aggactgtgc cattactgcc     3900

cgtctcaact gtccatgcag gaggacagag ttgcctggta ctcttaccct tgtccctctc     3960

ctaaagggag cacaaggaaa ctgaagagac tgaaaaagaa gagagtttgt agctgaaaaa     4020

gaatagggat agcaaggaaa cccagaactg cattccccta agtggggcca tcccatgtga     4080

ttgaattgtc catagcttgc ctatggtgag aaatgtgcat gctccgtgag ctggtctctt     4140

gaaacaggac ttatgcttcc tctatattct ggttaaattt tccaaacaca taagttcact     4200

gagcacagat ttcttatcca gagacaagta gaatctaacc gcagactgtt ggcagagttt     4260

ccaggcactt agccatgttc ccttcctgac tcaaatcccc aaaggccttc actctcactg     4320

agaatcacac tactgtccca tagataaggc aggcattgaa gcacctgtcg tgatcctcta     4380

ggggggagaa tgaaaggtta tttcctgcat tgcatcatca tagcttttaa tataatgcta     4440

cagaatcata tccacattag gttagagttc agatatttgg atatgaatac ctaacctagc     4500

catatccatg gccatctctg ttcttttcag caatgttttc catattatat tagcaatgac     4560

agaaacagaa caagccaaga tccagtcagt tcttgggagc ttgtctagag caccaagtaa     4620

tgaaatagcc aggtagtggg atgactgtac ctttaaaaat acataattta gtttgcaagc     4680

tatattatgc tactttctat tttccttgtt actttatagc aattcatttt accctcacaa     4740

agtcaattta gaaccttatc attaactggg atgtgtagtg atatttttgg gcctctgggt     4800

ttcatgtgtc aatacaagga atatttattt aaaatagatt tatttagagg aggcacagtg     4860

ttgttgatct gtgtgacacc acccatattt ttaaaaacct ttgtatgttt ctctaaattt     4920

gttgttgact gaatataata gaccctacca taattcgtca aatatcactg attagttaca     4980

tcctttgtgt gagattagct gtaaagtata ctgctcttat tcttattcag aatagttaat     5040

tggtagccaa aaatacatgt atcacagatg ttaggtcgaa tttaaacagc acagtcaagt     5100

gctatggaag tttttctgct aaattagtag attaaagaat actataccct aggcatgggg     5160

agcagcacgt tttcctttgg taggtaggat ctctatacta gtgaacagtg ccagttccac     5220

actttggact tagaactgtt ctctagttat tgtaacacag aatactgtca atccctaatt     5280

tacttaatgt tacttattgg aagtggggct gatgaaatac gcacaggagg gaaatctact     5340

gtgtttaggc acaggcagcc ccagtgtata aggagatcat attccaaaag gttgtcagtt     5400

ggttgtttgc aacctggaat gtattttcct ttagagacca ggttatccat ggtggttagg     5460

cccctagagc agctggaaaa gatgatcaaa ccaataggtt agctgacatc gaataatgta     5520

ataggtttgc taaagaatct aaccatcaaa tataatattg tttccaggga gggtgtttgt     5580

tcagagttgc ctgttagtag aatctggact gtccatccca gccacatccc acctactgga     5640

cagtaggggt agagatgcca ccagactaca ggtgaccaga ttggcctgaa acatggtgtc     5700

cagtaaaaac ggggaggaat aagtccatga ctgctggaga gcttggtggt aggaggaggg     5760

tgaaggaggg tgagggggcc tctcatgggt cagaaacctc cagggacatc cctcagctgg     5820

taactctgct gttgtccgga gggttcaggc ttggtgtgcc ttcttctgtt tgtctgactt     5880

ttggctccta tggttcatct cctgccctgc ccaccacaga aaaggatgct gctgcatagc     5940

ttctccaatg taccagtcat tgaggccagc gcgcagcact tttaatgttt ttagtgctag     6000

taactgtgtt ttaactctcc aggaataagc tgggaggtta gaaaacaaga aaaaaggggg     6060

aaaaaaaaac ctctccaccc actttccttt tttacagtta cagaccctgt tgagaaaaag     6120

aagcacccag atgggtgatg gtgatagggc ttgtggtgga cacagggttg tggtaagatt     6180

cctcagtgct tcggcgagca cctaagacta ttaccctgga actgactgct ttctagagct     6240

tgattcatgc ctctaagcca gtggttctca aagtgtggcc cctagaccag tagcatcagc     6300

atcatcgggg acctcattag aatgcagatt ctcagccccc tcccagacat ggtgaagtca     6360

gaagctctca gggagggact cagcaaatga ttctaaagcg catcaagttt gagaaccacc     6420

ctaagccaat gagtctccct tttacttccc attagtcctc cctcaccaga tgattcctag     6480

gactcatggt gcaacataca ggagccaggc tttagggagg ggaggaaagg agcctggcgg     6540

caggggtctc tgcaatggca agaaagtgag tgaatccagc gctgccacct ggttatcccc     6600

ttctcgttga aaatagcagc gcaggtgcaa attcctaaac acaggctgcc tgcactcggt     6660

gttacctcgg gctgaggcat gataatattt tattttttaa agctgtgagg aaatgaaagt     6720

gaggctttgg ttggggcgag gcagttgtga aagaaattaa aataaaagac cctttgtaaa     6780

tgcagactta gaagaaatac tgaatttgtg tcagaagttc tccagtgttt gtgttaatcg     6840

tgtggtgata atcctgtcct ccttttaaag cgaattctct actgaaaggt ctgctctgct     6900

taaggagcta caaactgctc tcaaaagaat gaaatactga gttccaattc agtgaggcac     6960

agtgttggac tatggcacat ttagttggag tcggggggag gtcaggaata tgatcagata     7020

atggatttta taccttagag caaaatctat tagtctctct cagtttatca atttaaatgg     7080

ctttaggctt atagggggtg taaactttaa gaatataatt ctcccattca agtttacagc     7140

aaacatctag ccaccttcaa aacaaagaat atacagacca tcatttagca atactaatac     7200

atgattttcc ttggggatgg caggtttgag aatcctttag caacaggaca tacttcccct     7260

aaattacagt gaattattta taacgagata aagctttcag gtacaagctg aaggtggggt     7320

gtctaacaac taaaaactat cactaaatct caaagagaaa gttcttgcaa aatatgtaaa     7380

gttcacaagg tgcagacatt ttccttcttt aggcttttat ctaaggaagg gctatgaaac     7440

tgggcccatc tgtatacagg ctcaaattta cgtttttaaa ggaagaatct atgcagctga     7500

ggcttattgc aggaaatact tcatttgtat gtaaatatta ttgtaaataa ataggaggct     7560

gtatattttt gaagttgttg atctgcactg aaatagaagt ctctaggatc tgcatataaa     7620

caataaatgt ttcctagaaa ttagtggttt tgtttgggaa ttagaaaaat ttacattctc     7680

tcccaggtaa catagttctc tcaatgtaaa cttggaacct gaaaccctac ttaatttaga     7740

gaaagaaatg tctgagaaat agttcccttg atttcttatg ctggcattaa gatcaattat     7800

ttaacagata gtcctctgag atacaagtaa ggaatattta gacacaaatc cttgtcctat     7860

agaaacagat atacccaaat gacaaattgt ttcttcataa tgatcttcca tttttaacac     7920

tgataccact acacagtaca tatgaaaaca gaagctgggg agaagaatgt ttttttcaca     7980

attgaattgc tgcatttctc aaactttggg atctatgaaa gcggggagag ggaacctgaa     8040

tattaattat gagcacaaat ttgaaggaaa gaaaacaaag aaccattatc taatcaagct     8100

ttgaaagtcc tgcatgtttg ccttttattt tagtgttgac gccaacatag actgtctaag     8160

gtattttttt ccccaaacac ttgaatcttg gtcgttggta tgtaatccac tctctagagt     8220

ccagtgtact ttagacttca tctgagtcca atacatgtac cacactactg ttttattaat     8280

gtaaaaacct tgtaaatgaa tttcagatgg gtgatttaag tgagtcacaa gtcacaaaac     8340

tttgctattc atagttaatc aaatagaact gggttttttt tttcagagtg tggtgtaaat     8400

aaagaaatat aagaagttct gttctataac tgctctgtta acatagtttt taaacattaa     8460

aaaatgtgaa ctaaaagtat ttaaaaa                                         8487


<210>  338
<211>  487
<212>  PRT
<213>  Homo Sapiens

<400>  338

Met Met His Phe Lys Ser Gly Leu Glu Leu Thr Glu Leu Gln Asn Met 
1               5                   10                  15      


Thr Val Pro Glu Asp Asp Asn Ile Ser Asn Asp Ser Asn Asp Phe Thr 
            20                  25                  30          


Glu Val Glu Asn Gly Gln Ile Asn Ser Lys Phe Ile Ser Asp Arg Glu 
        35                  40                  45              


Ser Arg Arg Ser Leu Thr Asn Ser His Leu Glu Lys Lys Lys Cys Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Gly Thr Thr Ser Leu Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Met Gly Ser Gly Ile Leu Gly Leu Ala Phe Ala Leu 
                85                  90                  95      


Ala Asn Thr Gly Ile Leu Leu Phe Leu Val Leu Leu Thr Ser Val Thr 
            100                 105                 110         


Leu Leu Ser Ile Tyr Ser Ile Asn Leu Leu Leu Ile Cys Ser Lys Glu 
        115                 120                 125             


Thr Gly Cys Met Val Tyr Glu Lys Leu Gly Glu Gln Val Phe Gly Thr 
    130                 135                 140                 


Thr Gly Lys Phe Val Ile Phe Gly Ala Thr Ser Leu Gln Asn Thr Gly 
145                 150                 155                 160 


Ala Met Leu Ser Tyr Leu Phe Ile Val Lys Asn Glu Leu Pro Ser Ala 
                165                 170                 175     


Ile Lys Phe Leu Met Gly Lys Glu Glu Thr Phe Ser Ala Trp Tyr Val 
            180                 185                 190         


Asp Gly Arg Val Leu Val Val Ile Val Thr Phe Gly Ile Ile Leu Pro 
        195                 200                 205             


Leu Cys Leu Leu Lys Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Phe 
    210                 215                 220                 


Ser Leu Ser Cys Met Val Phe Phe Leu Ile Val Val Ile Tyr Lys Lys 
225                 230                 235                 240 


Phe Gln Ile Pro Cys Ile Val Pro Glu Leu Asn Ser Thr Ile Ser Ala 
                245                 250                 255     


Asn Ser Thr Asn Ala Asp Thr Cys Thr Pro Lys Tyr Val Thr Phe Asn 
            260                 265                 270         


Ser Lys Thr Val Tyr Ala Leu Pro Thr Ile Ala Phe Ala Phe Val Cys 
        275                 280                 285             


His Pro Ser Val Leu Pro Ile Tyr Ser Glu Leu Lys Asp Arg Ser Gln 
    290                 295                 300                 


Lys Lys Met Gln Met Val Ser Asn Ile Ser Phe Phe Ala Met Phe Val 
305                 310                 315                 320 


Met Tyr Phe Leu Thr Ala Ile Phe Gly Tyr Leu Thr Phe Tyr Asp Asn 
                325                 330                 335     


Val Gln Ser Asp Leu Leu His Lys Tyr Gln Ser Lys Asp Asp Ile Leu 
            340                 345                 350         


Ile Leu Thr Val Arg Leu Ala Val Ile Val Ala Val Ile Leu Thr Val 
        355                 360                 365             


Pro Val Leu Phe Phe Thr Val Arg Ser Ser Leu Phe Glu Leu Ala Lys 
    370                 375                 380                 


Lys Thr Lys Phe Asn Leu Cys Arg His Thr Val Val Thr Cys Ile Leu 
385                 390                 395                 400 


Leu Val Val Ile Asn Leu Leu Val Ile Phe Ile Pro Ser Met Lys Asp 
                405                 410                 415     


Ile Phe Gly Val Val Gly Val Thr Ser Ala Asn Met Leu Ile Phe Ile 
            420                 425                 430         


Leu Pro Ser Ser Leu Tyr Leu Lys Ile Thr Asp Gln Asp Gly Asp Lys 
        435                 440                 445             


Gly Thr Gln Arg Ile Trp Ala Ala Leu Phe Leu Gly Leu Gly Val Leu 
    450                 455                 460                 


Phe Ser Leu Val Ser Ile Pro Leu Val Ile Tyr Asp Trp Ala Cys Ser 
465                 470                 475                 480 


Ser Ser Ser Asp Glu Gly His 
                485         


<210>  339
<211>  6330
<212>  DNA
<213>  Homo Sapiens

<400>  339
tgacgccccc gaacccagct gcagaagctg ccgccacctc caatgcacaa ggtgtctcat       60

ctgaaaagaa acctgagccc cagggaggcg gcgcggagcg accctggcag agctggcgca      120

aacagggcga gaggtcgctg ggcagcgttc gaggaccaga gggagctcgg ccacagaaga      180

ccccagtgat ctgatcccgg gatcccggct ccaagctctc ctcgcatttt acagatttca      240

cccccgcgac tatctcccca aaacggagcc tttatatcaa gagaaggtgc gggagctggg      300

gcaaccagga ctttctcggg cacccaagat gcgctccatt aggaagaggt ggacgatctg      360

cacaataagt ctgctcctga tcttttataa gacaaaagaa atagcaagaa ctgaggagca      420

ccaggagacg caactcatcg gagatggtga attgtctttg agtcggtcac ttgtcaatag      480

ctctgataaa atcattcgaa aggctggctc ttcaatcttc cagcacaatg tagaaggttg      540

gaaaatcaat tcctctttgg tcctagagat aaggaagaac atacttcgtt tcttagatgc      600

agaacgagat gtgtcagtgg tcaagagcag ttttaagcct ggtgatgtca tacactatgt      660

gcttgacagg cgccggacac taaacatttc tcatgatcta catagcctcc tacctgaagt      720

ttcaccaatg aagaatcgca ggtttaagac ctgtgcagtt gttggaaatt ctggcattct      780

gttagacagt gaatgtggaa aggagattga cagtcacaat tttgtaataa ggtgtaatct      840

agctcctgtg gtggagtttg ctgcagatgt gggaactaaa tcagatttta ttaccatgaa      900

tccatcagtt gtacaaagag catttggagg ctttcgaaat gagagtgaca gagaaaaatt      960

tgtgcataga ctttccatgc tgaatgacag tgtcctttgg attcctgctt tcatggtcaa     1020

aggaggagag aagcacgtgg agtgggttaa tgcattaatc cttaagaata aactgaaagt     1080

gcgaactgcc tatccgtcat tgagacttat tcatgctgtc agaggttact ggctgaccaa     1140

caaagttcct atcaaaagac ccagcacagg tcttctcatg tatacacttg ccacaagatt     1200

ctgtgatgaa attcacctgt atggattctg gcccttccct aaggatttaa atggaaaagc     1260

ggtcaaatat cattattatg atgacttaaa atataggtac ttttccaatg caagccctca     1320

cagaatgcca ttagaattca aaacattaaa tgtgctacat aatagaggag ctctaaaact     1380

gacaacagga aagtgtgtaa agcaataaag cacattttga aacaaacaat atgcacttct     1440

tttctgaaga tgcttccgaa gatttgaaaa taggatccaa aacacggctg ggtttcagca     1500

tccaccaatg aactgaaagg tgaataaagg acgttcatga gaaatcgact accagctgat     1560

gaaatacctg caaagtgctc taaaaattaa atattttgac tttaagggtc ctagtaagtg     1620

ccacttccac taagaataca gtttgaatgt ataatcagta gtgtttacaa gatccaacag     1680

tgcactcatc attagttaac aaagcaaata tgttcatcac tgtcaggctg cccacagcaa     1740

caccaagcat attagaagag gaaccccagg aacgcaactc agaccttggg aaattaaacc     1800

atccttgtca gcagaagcca agatggaagc agtttgagca atgaaatccg taagattaaa     1860

caactcaagt aaatgcttca gtcaggactc tgagtctgat catgaatttt atgttttaat     1920

ttatgttttt tttttgtctt ctggaatctc ttttggtttg gatattggga tgcttagaaa     1980

tcctttctga gatgcatatg agtgaggaaa taaactttaa gtaattattt ttaaagttct     2040

tatacttttt aaaagctatc acacaaagac tttttttttt ttttttgtct cgctctgttg     2100

cccaggctgg agtacagtgg cgcgatctca gctcactgca agctccgcct cccaagttca     2160

ctccattctc ctgcctcagc ctccggagta gctgggactg caggcgcctg ccaccacgcc     2220

tggctaattt tttgtatttt tagtggagac ggattttcac cgtgttagcc aggatggtct     2280

caatctcctg acctcgtgat ccacccgcct tggcctccca aagtgctggg attacaggcg     2340

tgagccaccg tgcctggccg acatttttaa aaaagtttta ttttgcacgg ctctaaacct     2400

ccatgttatt ttccagtggt gtagaaggta ccagctaaag tgaaccacta tgtaatatta     2460

ggccattcta aaggaaagat gttccatgtc atcagagatg gtaaaatagg ccgggaaaaa     2520

aaaatctttg gtaccaaaga ttacacttgt gtttctacac agcaaaccat ttttctttca     2580

tgaaaataat atattattaa catgaatata ttattttgct attaatgtga aagttgtctc     2640

taaatatttt ttaattttca aactcatact ttattttcat ttgaaatgtt tttcacacct     2700

tttgcattac ataataattt tgtggaagca ttttgccctt tagaataaat attagattga     2760

tatagctgaa atgtgacttc cagttctttg atattcccct tgttattcaa atagaaatat     2820

ggaaatgctt tatatattac tgttaaattt cttagtgcag aaataacatt attaatagag     2880

tattgttttc aaaacagaga tgattaattt caagaggttt aacagtgaaa ttgtgtcaat     2940

attttgcatt taaaatgaat ttaattgacc gatattttct gtagttaaat ttagtcacaa     3000

tatcacatat gttcttcaag aaacacatga aattattaat aaagtaatta aaaaattttt     3060

aatgtataac agaattgacc aataggccag ttttctggta acttatgata gtagattgtt     3120

tctttagaaa ctgggcagaa gctctgcatt ctcacttgta ctttgatttc ttatttcttg     3180

ggcaggcaat ttgaggaaag aagaaatggc atggggaata tatatgtttt gtttcttagg     3240

gaaaacagtc tgagaaatga ataaaaagca tgaagtacgt gtgtgtgtgt gtgtgttacc     3300

atggaaaagg atattcacag tagtacagtt ctcaatattt ttaattagat gtcatatttt     3360

tttaatatag taaaaccttg ggatatagaa tattacatct tttgagaatg tatgtgtctc     3420

taagtaagta aaatctaatg cgtataggag actgatagct aaaaatgaat ggaacattaa     3480

tgtactttta taattaaacc tcttatctat cagaaattgt aagagaatag atacatgttt     3540

tgaatgtaaa gttgaaaagt ctggtttact taataaattg aaagtgattt ataaaatcta     3600

aatttggact acttgcaaat gataagctat tctagtagcc tttagtttaa atccaacaga     3660

aatctagaag tcacaagcaa atatcttaaa ggtaaaatcc atctgggcac tcatttaaag     3720

tatatcttaa aaaagcagca gcaaggtacc ttgccatttt tagcatattt tcttcctttt     3780

tcttttttct tttttttttt tttttgagat ggagtctcac tctgtcacac aggctggaat     3840

gcagtgatgc catctcagct cactgcaacc tccacctcct gggttcaagt gattctcgtg     3900

cctcagcctc ccaagtagct ggggttacag gcgcccacca ccacactcgg ctaattttgt     3960

gtttttagta gagacaaagt ttcaccatgt tggccaggct ggtcttgaac ttcctgacct     4020

caggttatcc acccacctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgca     4080

gccggaccat ttttagtata ttttcagtaa atacatttaa acaatgttaa ggccacagca     4140

cacatatctc agccattcat tgttctgtgc attgatgttt atctcataga tgcattgagt     4200

agtgcctttt tagctttttc acattacttt gtcaccatat cctttgtgtt ctctaaatac     4260

attgcccact tccaaaaatg ttcagcatga aaaaaagggc ttcagtgtcg attgagattg     4320

cttttgttca tctcagggat ttcaatagtc aagaatgaat tcagttaaag gtatttaggg     4380

ttcaaagaag acaaactgta caagcccatt tcattccttg ttgtatacct ttccatctgc     4440

cctcccattt taactatcta ctgtggcctt tttatggaaa cagagcaaga tcaatgaagg     4500

ctaatggcaa gaataagaaa aagagttgag atttaaccaa tagcggagca taaaggatca     4560

tgacaaaatc aaattataaa agcatacttg aaataggtgg agctttttct tttgaaaata     4620

tatattcaca attttaatat tttaatttat tttttactat ttaaccctgt acttggcaat     4680

gctcaggcag ctgattgtga aatattcttg tcctttacag aacatggttg ttattgtgct     4740

gttgacatga atagaccatg gaaacatttt catcattatt attcagcctg tgctgtagtt     4800

aatgttaagt tgctgaaata aaaagtgagc aagtaataga ttttcttggc aaatctaatg     4860

attcagccca caggactgtt gaaactactg cggaagtttt tctatctgaa agaaggtgct     4920

gggcattcaa atgtgttcat gtattgtata tcatatgaat tgtatatcaa ttactaatgg     4980

gaatttctac atatatgctt acaaaagcaa tttatttaag taatgctagg ggtagtgtac     5040

ataccaatta gttattcagc tactatacag aaaaaggatg aacaaattaa tttatttcta     5100

attgagccag ttagacataa tgcatataac gtgatatttg gttcatgaaa gagttgtttt     5160

catgtggtta ttgtagggag tatatataat tgtggaaggg gtatgggaag agttgtgtat     5220

agttagttgt tatctctaca agtttgaaag ttttcccatc aaacattatc aatataccaa     5280

tgttttaaaa attgagtgag ggttattatt tgtatttgat gaaagaaaat ccaaataaag     5340

cccacctaga aatagatatt ttattatata tgtgctatag atatacctat atagtacaaa     5400

tagacatgtg tgatgcatat atacaatgtt atatatgtgt atatgtctgt atacacactg     5460

agtctgtaat atgtatacac taaatttgtg ttatgctaac atcttcaggg tctgcactgt     5520

gaactcccct ggagataagt aagtccactt tagaataaag aagttctttt gagacttcag     5580

ttactaacgt gctttaagag gtatctactt tataactgaa ttctatgtcg ttcatacgta     5640

gagttacagt aagggtctag tatgtccaaa tcttaataat aaagaagaaa agtaaaggct     5700

tcaagctagc aatgtattcg aattacagtt ttcagattgt ggctccaggc cttgtgtttc     5760

tcatttaagt agcacctttt aataaaaacc gtttctttgt gtaggcaaaa gcacaagtgt     5820

ttcaaatgta aatagcagga aaaaaaaaga gtttacagag atagcattgc tgcacagaat     5880

aattgctact gagtatttct tatagaattt gtggaactga aagatgaggt ttattctgtc     5940

aagttcaagt tcattctgtt caacactgtt ttcttattgt ttgtgtatag caaccgggta     6000

ttattgtttt atcatttgta aaattgtaaa ataaattaat cccttttttt cactgtttct     6060

cttatctcat atatccaagc ccttggttat actttgtatg tcaatgttag gtgatcattt     6120

ttaacaagct ttggcttgtg ctttgctttt ccactcccct tagccctagt ggttggcaat     6180

taggcaaacc atttattttt aagtgtatac atgggaatat gaacaatgtc aaaaacccca     6240

tgaatattag gaaatcctta acgatatttt gtgtagcaca ttctgtttgc ggttgaggga     6300

ataaagtatt tcacaagtga aaaaaaaaaa                                      6330


<210>  340
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  340

Met Arg Ser Ile Arg Lys Arg Trp Thr Ile Cys Thr Ile Ser Leu Leu 
1               5                   10                  15      


Leu Ile Phe Tyr Lys Thr Lys Glu Ile Ala Arg Thr Glu Glu His Gln 
            20                  25                  30          


Glu Thr Gln Leu Ile Gly Asp Gly Glu Leu Ser Leu Ser Arg Ser Leu 
        35                  40                  45              


Val Asn Ser Ser Asp Lys Ile Ile Arg Lys Ala Gly Ser Ser Ile Phe 
    50                  55                  60                  


Gln His Asn Val Glu Gly Trp Lys Ile Asn Ser Ser Leu Val Leu Glu 
65                  70                  75                  80  


Ile Arg Lys Asn Ile Leu Arg Phe Leu Asp Ala Glu Arg Asp Val Ser 
                85                  90                  95      


Val Val Lys Ser Ser Phe Lys Pro Gly Asp Val Ile His Tyr Val Leu 
            100                 105                 110         


Asp Arg Arg Arg Thr Leu Asn Ile Ser His Asp Leu His Ser Leu Leu 
        115                 120                 125             


Pro Glu Val Ser Pro Met Lys Asn Arg Arg Phe Lys Thr Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Ile Leu Leu Asp Ser Glu Cys Gly Lys Glu Ile 
145                 150                 155                 160 


Asp Ser His Asn Phe Val Ile Arg Cys Asn Leu Ala Pro Val Val Glu 
                165                 170                 175     


Phe Ala Ala Asp Val Gly Thr Lys Ser Asp Phe Ile Thr Met Asn Pro 
            180                 185                 190         


Ser Val Val Gln Arg Ala Phe Gly Gly Phe Arg Asn Glu Ser Asp Arg 
        195                 200                 205             


Glu Lys Phe Val His Arg Leu Ser Met Leu Asn Asp Ser Val Leu Trp 
    210                 215                 220                 


Ile Pro Ala Phe Met Val Lys Gly Gly Glu Lys His Val Glu Trp Val 
225                 230                 235                 240 


Asn Ala Leu Ile Leu Lys Asn Lys Leu Lys Val Arg Thr Ala Tyr Pro 
                245                 250                 255     


Ser Leu Arg Leu Ile His Ala Val Arg Gly Tyr Trp Leu Thr Asn Lys 
            260                 265                 270         


Val Pro Ile Lys Arg Pro Ser Thr Gly Leu Leu Met Tyr Thr Leu Ala 
        275                 280                 285             


Thr Arg Phe Cys Asp Glu Ile His Leu Tyr Gly Phe Trp Pro Phe Pro 
    290                 295                 300                 


Lys Asp Leu Asn Gly Lys Ala Val Lys Tyr His Tyr Tyr Asp Asp Leu 
305                 310                 315                 320 


Lys Tyr Arg Tyr Phe Ser Asn Ala Ser Pro His Arg Met Pro Leu Glu 
                325                 330                 335     


Phe Lys Thr Leu Asn Val Leu His Asn Arg Gly Ala Leu Lys Leu Thr 
            340                 345                 350         


Thr Gly Lys Cys Val Lys Gln 
        355                 


<210>  341
<211>  7529
<212>  DNA
<213>  Homo Sapiens

<400>  341
gcctctgggg cagaccctgg agatcgggct cgcggcgcct tccatcgtgg ctccgcgctg       60

gggcttgcgg agcacgcttc ccgcccctcg gagcccgcgg gcccggccgc cccgcccccg      120

ggcgccctga gcgagcaggc ggggagggcg gggagggtcc gcgcgttggt ggtgctcgcc      180

tcgcagctgc gcccgccggc ttcagcacct tccgctgtcc gccgctgcag ccgcctcctc      240

ctccaggtgc tgactattct gatgccgagt ttccaattgc cttgattaaa gtagaaacat      300

tctatggctt ggatgactta catttcaaat tggtttgagc aagatgattg gtatgaagga      360

ctacaaagag caaacatgtc ccaggtaagg caagtgggat tgctggctgc tggatgtcag      420

ccatggaaca aggatgtatg tgctgccagt ggagacaggt ttgcatattg tgcgaccctg      480

gctatctata tttatcagtt ggatcaccgt tataatgaat tcaaacttca cgcaattatg      540

tctgaacata aaaaaacaat cacagcaatt tcttggtgtc cacataatcc tgatctgttt      600

gcaagtggca gtactgataa tttagtgatc atttggaatg ttgcagaaca aaaagtcatt      660

gctaaactcg acagtacaaa agggatccct gcttctctta gttggtgctg gaatgcagag      720

gatgtggtgg catttgtttc ccacagaggc ccactgttca tttggaccat ctcaggacca      780

gatagtggag tgattgtaca caaagatgct catagcttct tgtctgatat ctgtatgttc      840

agatggcata cacaccaaaa ggggaaagtt gtgtttggtc atattgatgg aagtctatca      900

atttttcatc caggtaataa aaatcagaaa catgttttga gaccagaatc tcttgaaggg      960

acagatgaag aggatccagt tacggccttg gaatgggacc cactatctac tgattatctt     1020

ctagtggtta atttgcatta tggaattcgc ctggtagatt ctgaatcact ttcttgcata     1080

acaacattta atcttcccag tgcagcagct tctgtacagt gcttagcctg ggttcccagt     1140

gctcctggga tgtttataac tggagattct caagtgggtg ttttacgcat ttggaatgtt     1200

tcaagaacaa cacctattga taatcttaaa ttaaagaaaa caggatttca ctgcttacat     1260

gtacttaatt ctcctccaag aaaaaagttt tcagtccaat ctccaaccaa aaatcattat     1320

acatcctcaa caagcgaagc agttccaccc ccaactttaa cacagaatca agcattttct     1380

cttcctcctg gtcatgcagt gtgttgtttc ttggatggtg gagttggact ttatgatatg     1440

ggagctaaga agtgggattt tcttagagac ttgggacatg tggaaactat ctttgactgc     1500

aaattcaaac ctgacgatcc taatctttta gcaacagctt catttgatgg cactataaaa     1560

gtctgggata taaacacatt aacagcagtg tacacatccc cgggtaatga aggtgttatt     1620

tattcccttt cttgggctcc aggtggttta aattgtattg ctgggggaac ttcccgaaat     1680

ggtgctttta tttggaatgt tcaaaagggc aaaattatac aacgatttaa tgagcatgga     1740

acaaatggaa tattctgcat tgcctggagt cataaagatt ctaaaagaat agcaacctgc     1800

agcagtgatg gtttctgtat tattcgaaca attgatggta aagtgctaca caaatataaa     1860

catccagctg cagtgtttgg ttgtgattgg agccaaaaca ataaagacat gatagccact     1920

ggctgtgaag acacaaatgt tcgtgtttat tatgtagcca ccagctcaga tcaaccattg     1980

aaagtattta gtgggcatac agcaaaagtg tttcatgtta aatggtctcc tctgagagag     2040

ggaattcttt gcagtggttc tgatgatggt accgttcgaa tctgggatta tactcaggat     2100

gcttgcatca atattcttaa tggacacact gcacctgtga gaggattaat gtggaatact     2160

gagattccat atctgctcat atctggcagc tgggactata ctataaaagt atgggacact     2220

cgagaaggaa cttgtgtgga tactgtgtat gatcacggtg cagatgtata tggtttaacc     2280

tgccatccca gtcgcccctt cactatggcc tcttgctccc gtgactctac agtgagactc     2340

tggtcattaa cagccttagt cactcctgta caaataaata ttctggcaga cagatcttgg     2400

gaagaaatta ttgggaacac tgattatgct atagaaccag gcactcctcc tctactgtgt     2460

ggtaaagtgt caagagatat tagacaggaa atagaaaaac taactgctaa ttctcaagtg     2520

aaaaaactaa gatggttctc agaatgttta tctcctccag gtggcagtga caatttatgg     2580

aacttggttg ctgtgataaa aggacaggat gatagcttac ttcctcagaa ctactgcaaa     2640

ggaataatgc acttgaaaca tctgattaaa tttagaacat ctgaagctca agaactaaca     2700

acagtcaaga tgtctaaatt tggtggtggt attggtgtac ctgctaaaga ggaaagactg     2760

aaggaagctg ctgaaatcca cttgagatta ggacaaattc agagatactg tgaacttatg     2820

gttgaacttg gagagtggga caaagccctg tcaattgcac caggagtctc tgtgaaatac     2880

tggaagaagt taatgcagag gagagctgac caattaatcc aggaagataa ggatgatgtc     2940

attccatact gcatagccat tggtgatgtg aaaaagctag tccatttttt catgtcaaga     3000

ggtcagctta aagaagctct gcttgttgca caggctgctt gtgaaggaaa tatgcagccc     3060

ttacatgttt ccgtgcctaa aggagcttca tattctgatg atatctacaa ggaagacttt     3120

aatgaactcc tgcacaaagt cagtaaagaa ctggcagaat ggtattttca agatggtcga     3180

gcagtactag ccgcatgttg ccatcttgcc atagataata ttgagcttgc tatggcatac     3240

ctgattcgcg gaaatgaact ggagttggca gtctgtgtgg gcacagtact aggagagtct     3300

gcagcaccag caacccacta tgccttagaa ttactggcga gaaagtgcat gatgatttca     3360

gtatgctttc catgtgttgg atacagtgtc cccttttgtt acgttaacag gaatttggca     3420

gctgatcttc ttctgatgat tcctgataat gaactacatt taataaaact ctgtgctttc     3480

tacccaggat gtactgaaga gataaatgac cttcatgata agtgtaagct acccacagtg     3540

gaagaatgta tgcagttagc tgagacagcc cgtgcagatg acaatatatt tgaaactgta     3600

aaatattact tgttaagtca agaacctgaa aaagcccttc ctattggtat tagctttgtt     3660

aaagaataca tcagtagctc agactggact ttggatacca tataccctgt tcttgaccta     3720

ctgagctata ttcgtactga aaaattactc ttgcatacgt gtactgaagc tcgaaatgag     3780

ttgctgatat tatgtggtta cattggtgca ttactggcta tcagaagaca gtaccaaagc     3840

attgttccag cactttatga gtacacaagt cagctattaa aacgtcggga ggtgtcagta     3900

cctttaaaaa ttgaatatct ttctgaggaa ttggatgcat ggagagcttg cacacagtcc     3960

accaacagat cattagaaga ctctccgtat acaccccctt ctgattcaca aagaatgatt     4020

tatgcaactt tattaaagag actaaaagaa gagtcactga aaggaattat tggaccagat     4080

tatgtgactg gatcaaatct tccaagtcat tctgatattc acatttcttg tcttacggga     4140

ttaaaaatcc agggccctgt gtttttcctt gaagacggga aatctgctat ctccttgaat     4200

gatgctttga tgtgggcaaa ggtgaatcca ttctcacctt tagggactgg aatacgactc     4260

aatccattct gatagaagat ttttgtccat gcttgatttt tttttttaaa gaaaaacttt     4320

catgggttag cattacctta atctttgttg ctcaagtgcc agaggttggg agaaggattg     4380

caggttggga gaggtgggaa atagcagtga attttagtca ttaacttcaa aatatatata     4440

tatatataat ttaaaggaaa aataggtgcc tcctttataa acagtaatag ctacgtttgg     4500

gaaggaggaa acatttaaat tataaaggac tgaataatct aaaaagcata taaaagtttc     4560

acacagcata aaagatacca aaatatcata tggttgaaat attgaaacat attaaattgt     4620

gcaacaccta gaatagtgct agacatacag taagtactta atggatattt gaatgattga     4680

atatcttgaa atgttgaaat gtaaggtgtg cacagtgatc ttcaacttaa caaacactta     4740

cgttctcctt tataaaatgc atagtaaacc actaacgtta gctgttttaa taaaagtttt     4800

cagttataag tttagtaaat attaataaat ggatacacat tcaaaatact tttaaaaaaa     4860

agaaaatgtt accagttttt ttatctgaag tttaactgtc ccattgtaaa ggtgtaagtt     4920

atataggctt gaaaaaaatt ggcgggtaaa aatcacaaaa tgcagtcgaa tatatatatg     4980

aaaacttgca ttaggtgata aagtgactat tttaagagat tcagcatgca tggatattag     5040

ttttgattaa tgtgtacaat aatttacaca gtatactcta gtcaatttat gttaacttta     5100

tttaaaacac aatttatttg gccgggcacg gtggctcaca cctgtaatct cagcactttg     5160

gcaggccaag gcaggtggat cacctgaggt caggagttca tgaccagcct ggccagcatg     5220

gtaaaaccct gtctccacta aaaatacaaa aattagccag gcatggtggc gggcacctgt     5280

aatcccagtt acttgggaag ctgaggcagg agaatccctt gaacctggga ggcagaggtt     5340

ccagtgagcc aagatcgcac cactgcactc cagcctgggc aacaaagagc gaaactctgt     5400

ctcaaaaaac aaaccaacaa aaaccacaat tgatttgatg aaaattagtt ttaagtaaat     5460

gtttgtaaat agatattggt tgaatttttg gatatattat gttgatttaa cttttaaaat     5520

gttgtttaaa agtgtgaagc tatgaaaagc ctgataatgt gactacagat atttcagttg     5580

gactagaatt ctgactttga aacttattaa attaatgcat actggaagta ctttgatact     5640

caagttgttt cacaagattt ataatataga tggttttgtt tgactaaaga ataatctcat     5700

ataactagaa tacttgtggc ttttattatc tttaaacttg ttgcatttaa aatattttta     5760

aaaccttctt aacaaaactt cttaaaactg gaaaaaatat atattatgta tctatgtatc     5820

atatttatca catgaccact tttgattcct taaaaagaca ttacaggctt aaattccatt     5880

ttattaaaaa aaaaaaattg cctgtaatcc cagcacttca ggaggccgag atgggcagat     5940

cttgaggtcg gtagatggag accatcctgg ccaacatggt gaaaccctgt ctctactaaa     6000

aatacaaaaa ttagctgggt gtggtggtgt gtacctgtag tcccagctac ccaggaagct     6060

aaggcaggag aatcgcttga atccaggagg cggaggttgc agtgagctga gatcgcacta     6120

ctgcactcca gcctgggcga cagagcaaga ccaccatctc caaaaattat atatataaaa     6180

ataattaata ttatagaaga gaatatacac aactcagaga tgcaatggat aatataaaaa     6240

gagtacctga gatgtatttt tttaaactct tagagatatc tgtaactcaa atttttctta     6300

ggtgaggagg attattaact ggcacatatg tactaaaaac ccctcactta aaaatggcag     6360

tctcaatcct actgtcattc tttttatttt aaaataaata aataagccta tctttttgtg     6420

cttacatact taaaaggata tcattaagta tataaacaat cattacttct gtatttttaa     6480

tgaatgcagg aaaataatat ttttatgtat aaaagatgaa gaaaaaattt tgcaagtctt     6540

taagcacata aatacaacag aatagccacc caatttctgt ctgaaatcta aattggatgg     6600

atttgaccat cattctatta tctttgattt ctacaatgtc tatatcttat tacctataac     6660

tattaatttt tcatagaatt ataaatgtca tttgactatg tcaatctgta tatattgtac     6720

cttaatatga aaaacaaatt ttttaattca taaaagtatt tttattagat ttcatatgca     6780

tgaaacccaa gcaaattata tgaatttatt ttactatttg aaaatgttca tattaccaat     6840

aatgtggaca aattactttg caggtttaaa tatgcctctg taaaggaaga gtctcattag     6900

acaatgattt ttaaagcatt ggaaaaatat tttgcctgta aaagttagta actaggtggt     6960

tcacaaaatt acaacatcaa aatagttaca tcttgtgaaa atatatgatt tttatgtcaa     7020

tcaagacaaa tgaaatatat atgtatgtgt atatatatac atgtatgtat gaaatatata     7080

tatgtgcgtg tgtgtgtgta tatatatata tatatatata tatttctatg aaattgtcca     7140

gatgtgttca ggaacatgat tgcattagag caatgactgt attttgttgt ccttataaca     7200

tttatattat ttcagtttta agtcaaaagg tattctgaat ataataaaag cctcacaaat     7260

tatttgtaaa atttagtagt tcatatttag tatatcagta atatagaaga catctttata     7320

gtcaactctt aattaatgct tattgtacca aatctttgag atatttgtac ataaatgaaa     7380

tatgtacttt catgctaaaa ttatatatca tgactgtgct ataatttggc atgtcattat     7440

ctagatttat atgtatgtac gtatttcagg tccttgaaat tttaataaat attacagtta     7500

aatcctgata tgacatagtt aaaaaaaaa                                       7529


<210>  342
<211>  1322
<212>  PRT
<213>  Homo Sapiens

<400>  342

Met Ala Trp Met Thr Tyr Ile Ser Asn Trp Phe Glu Gln Asp Asp Trp 
1               5                   10                  15      


Tyr Glu Gly Leu Gln Arg Ala Asn Met Ser Gln Val Arg Gln Val Gly 
            20                  25                  30          


Leu Leu Ala Ala Gly Cys Gln Pro Trp Asn Lys Asp Val Cys Ala Ala 
        35                  40                  45              


Ser Gly Asp Arg Phe Ala Tyr Cys Ala Thr Leu Ala Ile Tyr Ile Tyr 
    50                  55                  60                  


Gln Leu Asp His Arg Tyr Asn Glu Phe Lys Leu His Ala Ile Met Ser 
65                  70                  75                  80  


Glu His Lys Lys Thr Ile Thr Ala Ile Ser Trp Cys Pro His Asn Pro 
                85                  90                  95      


Asp Leu Phe Ala Ser Gly Ser Thr Asp Asn Leu Val Ile Ile Trp Asn 
            100                 105                 110         


Val Ala Glu Gln Lys Val Ile Ala Lys Leu Asp Ser Thr Lys Gly Ile 
        115                 120                 125             


Pro Ala Ser Leu Ser Trp Cys Trp Asn Ala Glu Asp Val Val Ala Phe 
    130                 135                 140                 


Val Ser His Arg Gly Pro Leu Phe Ile Trp Thr Ile Ser Gly Pro Asp 
145                 150                 155                 160 


Ser Gly Val Ile Val His Lys Asp Ala His Ser Phe Leu Ser Asp Ile 
                165                 170                 175     


Cys Met Phe Arg Trp His Thr His Gln Lys Gly Lys Val Val Phe Gly 
            180                 185                 190         


His Ile Asp Gly Ser Leu Ser Ile Phe His Pro Gly Asn Lys Asn Gln 
        195                 200                 205             


Lys His Val Leu Arg Pro Glu Ser Leu Glu Gly Thr Asp Glu Glu Asp 
    210                 215                 220                 


Pro Val Thr Ala Leu Glu Trp Asp Pro Leu Ser Thr Asp Tyr Leu Leu 
225                 230                 235                 240 


Val Val Asn Leu His Tyr Gly Ile Arg Leu Val Asp Ser Glu Ser Leu 
                245                 250                 255     


Ser Cys Ile Thr Thr Phe Asn Leu Pro Ser Ala Ala Ala Ser Val Gln 
            260                 265                 270         


Cys Leu Ala Trp Val Pro Ser Ala Pro Gly Met Phe Ile Thr Gly Asp 
        275                 280                 285             


Ser Gln Val Gly Val Leu Arg Ile Trp Asn Val Ser Arg Thr Thr Pro 
    290                 295                 300                 


Ile Asp Asn Leu Lys Leu Lys Lys Thr Gly Phe His Cys Leu His Val 
305                 310                 315                 320 


Leu Asn Ser Pro Pro Arg Lys Lys Phe Ser Val Gln Ser Pro Thr Lys 
                325                 330                 335     


Asn His Tyr Thr Ser Ser Thr Ser Glu Ala Val Pro Pro Pro Thr Leu 
            340                 345                 350         


Thr Gln Asn Gln Ala Phe Ser Leu Pro Pro Gly His Ala Val Cys Cys 
        355                 360                 365             


Phe Leu Asp Gly Gly Val Gly Leu Tyr Asp Met Gly Ala Lys Lys Trp 
    370                 375                 380                 


Asp Phe Leu Arg Asp Leu Gly His Val Glu Thr Ile Phe Asp Cys Lys 
385                 390                 395                 400 


Phe Lys Pro Asp Asp Pro Asn Leu Leu Ala Thr Ala Ser Phe Asp Gly 
                405                 410                 415     


Thr Ile Lys Val Trp Asp Ile Asn Thr Leu Thr Ala Val Tyr Thr Ser 
            420                 425                 430         


Pro Gly Asn Glu Gly Val Ile Tyr Ser Leu Ser Trp Ala Pro Gly Gly 
        435                 440                 445             


Leu Asn Cys Ile Ala Gly Gly Thr Ser Arg Asn Gly Ala Phe Ile Trp 
    450                 455                 460                 


Asn Val Gln Lys Gly Lys Ile Ile Gln Arg Phe Asn Glu His Gly Thr 
465                 470                 475                 480 


Asn Gly Ile Phe Cys Ile Ala Trp Ser His Lys Asp Ser Lys Arg Ile 
                485                 490                 495     


Ala Thr Cys Ser Ser Asp Gly Phe Cys Ile Ile Arg Thr Ile Asp Gly 
            500                 505                 510         


Lys Val Leu His Lys Tyr Lys His Pro Ala Ala Val Phe Gly Cys Asp 
        515                 520                 525             


Trp Ser Gln Asn Asn Lys Asp Met Ile Ala Thr Gly Cys Glu Asp Thr 
    530                 535                 540                 


Asn Val Arg Val Tyr Tyr Val Ala Thr Ser Ser Asp Gln Pro Leu Lys 
545                 550                 555                 560 


Val Phe Ser Gly His Thr Ala Lys Val Phe His Val Lys Trp Ser Pro 
                565                 570                 575     


Leu Arg Glu Gly Ile Leu Cys Ser Gly Ser Asp Asp Gly Thr Val Arg 
            580                 585                 590         


Ile Trp Asp Tyr Thr Gln Asp Ala Cys Ile Asn Ile Leu Asn Gly His 
        595                 600                 605             


Thr Ala Pro Val Arg Gly Leu Met Trp Asn Thr Glu Ile Pro Tyr Leu 
    610                 615                 620                 


Leu Ile Ser Gly Ser Trp Asp Tyr Thr Ile Lys Val Trp Asp Thr Arg 
625                 630                 635                 640 


Glu Gly Thr Cys Val Asp Thr Val Tyr Asp His Gly Ala Asp Val Tyr 
                645                 650                 655     


Gly Leu Thr Cys His Pro Ser Arg Pro Phe Thr Met Ala Ser Cys Ser 
            660                 665                 670         


Arg Asp Ser Thr Val Arg Leu Trp Ser Leu Thr Ala Leu Val Thr Pro 
        675                 680                 685             


Val Gln Ile Asn Ile Leu Ala Asp Arg Ser Trp Glu Glu Ile Ile Gly 
    690                 695                 700                 


Asn Thr Asp Tyr Ala Ile Glu Pro Gly Thr Pro Pro Leu Leu Cys Gly 
705                 710                 715                 720 


Lys Val Ser Arg Asp Ile Arg Gln Glu Ile Glu Lys Leu Thr Ala Asn 
                725                 730                 735     


Ser Gln Val Lys Lys Leu Arg Trp Phe Ser Glu Cys Leu Ser Pro Pro 
            740                 745                 750         


Gly Gly Ser Asp Asn Leu Trp Asn Leu Val Ala Val Ile Lys Gly Gln 
        755                 760                 765             


Asp Asp Ser Leu Leu Pro Gln Asn Tyr Cys Lys Gly Ile Met His Leu 
    770                 775                 780                 


Lys His Leu Ile Lys Phe Arg Thr Ser Glu Ala Gln Glu Leu Thr Thr 
785                 790                 795                 800 


Val Lys Met Ser Lys Phe Gly Gly Gly Ile Gly Val Pro Ala Lys Glu 
                805                 810                 815     


Glu Arg Leu Lys Glu Ala Ala Glu Ile His Leu Arg Leu Gly Gln Ile 
            820                 825                 830         


Gln Arg Tyr Cys Glu Leu Met Val Glu Leu Gly Glu Trp Asp Lys Ala 
        835                 840                 845             


Leu Ser Ile Ala Pro Gly Val Ser Val Lys Tyr Trp Lys Lys Leu Met 
    850                 855                 860                 


Gln Arg Arg Ala Asp Gln Leu Ile Gln Glu Asp Lys Asp Asp Val Ile 
865                 870                 875                 880 


Pro Tyr Cys Ile Ala Ile Gly Asp Val Lys Lys Leu Val His Phe Phe 
                885                 890                 895     


Met Ser Arg Gly Gln Leu Lys Glu Ala Leu Leu Val Ala Gln Ala Ala 
            900                 905                 910         


Cys Glu Gly Asn Met Gln Pro Leu His Val Ser Val Pro Lys Gly Ala 
        915                 920                 925             


Ser Tyr Ser Asp Asp Ile Tyr Lys Glu Asp Phe Asn Glu Leu Leu His 
    930                 935                 940                 


Lys Val Ser Lys Glu Leu Ala Glu Trp Tyr Phe Gln Asp Gly Arg Ala 
945                 950                 955                 960 


Val Leu Ala Ala Cys Cys His Leu Ala Ile Asp Asn Ile Glu Leu Ala 
                965                 970                 975     


Met Ala Tyr Leu Ile Arg Gly Asn Glu Leu Glu Leu Ala Val Cys Val 
            980                 985                 990         


Gly Thr Val Leu Gly Glu Ser Ala  Ala Pro Ala Thr His  Tyr Ala Leu 
        995                 1000                 1005             


Glu Leu  Leu Ala Arg Lys Cys  Met Met Ile Ser Val  Cys Phe Pro 
    1010                 1015                 1020             


Cys Val  Gly Tyr Ser Val Pro  Phe Cys Tyr Val Asn  Arg Asn Leu 
    1025                 1030                 1035             


Ala Ala  Asp Leu Leu Leu Met  Ile Pro Asp Asn Glu  Leu His Leu 
    1040                 1045                 1050             


Ile Lys  Leu Cys Ala Phe Tyr  Pro Gly Cys Thr Glu  Glu Ile Asn 
    1055                 1060                 1065             


Asp Leu  His Asp Lys Cys Lys  Leu Pro Thr Val Glu  Glu Cys Met 
    1070                 1075                 1080             


Gln Leu  Ala Glu Thr Ala Arg  Ala Asp Asp Asn Ile  Phe Glu Thr 
    1085                 1090                 1095             


Val Lys  Tyr Tyr Leu Leu Ser  Gln Glu Pro Glu Lys  Ala Leu Pro 
    1100                 1105                 1110             


Ile Gly  Ile Ser Phe Val Lys  Glu Tyr Ile Ser Ser  Ser Asp Trp 
    1115                 1120                 1125             


Thr Leu  Asp Thr Ile Tyr Pro  Val Leu Asp Leu Leu  Ser Tyr Ile 
    1130                 1135                 1140             


Arg Thr  Glu Lys Leu Leu Leu  His Thr Cys Thr Glu  Ala Arg Asn 
    1145                 1150                 1155             


Glu Leu  Leu Ile Leu Cys Gly  Tyr Ile Gly Ala Leu  Leu Ala Ile 
    1160                 1165                 1170             


Arg Arg  Gln Tyr Gln Ser Ile  Val Pro Ala Leu Tyr  Glu Tyr Thr 
    1175                 1180                 1185             


Ser Gln  Leu Leu Lys Arg Arg  Glu Val Ser Val Pro  Leu Lys Ile 
    1190                 1195                 1200             


Glu Tyr  Leu Ser Glu Glu Leu  Asp Ala Trp Arg Ala  Cys Thr Gln 
    1205                 1210                 1215             


Ser Thr  Asn Arg Ser Leu Glu  Asp Ser Pro Tyr Thr  Pro Pro Ser 
    1220                 1225                 1230             


Asp Ser  Gln Arg Met Ile Tyr  Ala Thr Leu Leu Lys  Arg Leu Lys 
    1235                 1240                 1245             


Glu Glu  Ser Leu Lys Gly Ile  Ile Gly Pro Asp Tyr  Val Thr Gly 
    1250                 1255                 1260             


Ser Asn  Leu Pro Ser His Ser  Asp Ile His Ile Ser  Cys Leu Thr 
    1265                 1270                 1275             


Gly Leu  Lys Ile Gln Gly Pro  Val Phe Phe Leu Glu  Asp Gly Lys 
    1280                 1285                 1290             


Ser Ala  Ile Ser Leu Asn Asp  Ala Leu Met Trp Ala  Lys Val Asn 
    1295                 1300                 1305             


Pro Phe  Ser Pro Leu Gly Thr  Gly Ile Arg Leu Asn  Pro Phe 
    1310                 1315                 1320         


<210>  343
<211>  4809
<212>  DNA
<213>  Homo Sapiens

<400>  343
gtgaactgtt gcaccgtgca attgcacact ataaatgtct ttccttatct gtgtgtactc       60

ttatctcact gttctatttt ttctcctcat ttatattaac tctttcttac ctttttttct      120

gaacttctag gccttctctt tccagaactg gtggaagaca aatgaaacgg ccaagatggt      180

aagaaacaag ccgcatttct ccttggggag actgataatt taaaaggttt gttgtgtcag      240

aaacattccc agcttcatca ccaacccttt ccttccacct ctgcccactg gagaccactt      300

atatcccgaa gcggacgcgg cagctgaagt caggaaacca tgcatcacat tagcaggagc      360

caactgcaga ctttaaactc cgttcaacat gtggatgcgg cagagaaatg acctgtccag      420

acaagccggg gcagctcata aactggttca tctgctccct gtgcgtcccg cgggtgcgta      480

agctctggag cagccggcgt ccaaggaccc ggagaaacct tctgctgggc actgcgtgtg      540

ccatctactt gggcttcctg gtgagccagg tggggagggc ctctctccag catggacagg      600

cggctgagaa ggggccacat cgcagccgcg acaccgccga gccatccttc cctgagatac      660

ccctggatgg taccctggcc cctccagagt cccagggcaa tgggtccact ctgcagccca      720

atgtggtgta cattacccta cgctccaagc gcagcaagcc ggccaatatc cgtggcaccg      780

tgaagcccaa gcgcaggaaa aagcatgcag tggcatcggc tgccccaggg caggaggctt      840

tggtcggacc atcccttcag ccgcaggaag cggcaaggga agctgatgct gtagcacctg      900

ggtacgctca gggagcaaac ctggttaaga ttggagagcg accctggagg ttggtgcggg      960

gtccgggagt gcgagccggg ggcccagact tcctgcagcc cagctccagg gagagcaaca     1020

ttaggatcta cagcgagagc gccccctcct ggctgagcaa agatgacatc cgaagaatgc     1080

gactcttggc ggacagcgca gtggcagggc tccggcctgt gtcctctagg agcggagccc     1140

gtttgctggt gctggagggg ggcgcacctg gcgctgtgct ccgctgtggc cctagcccct     1200

gtgggcttct caagcagccc ttggacatga gtgaggtgtt tgccttccac ctagacagga     1260

tcctggggct caacaggacc ctgccgtctg tgagcaggaa agcagagttc atccaagatg     1320

gccgcccatg ccccatcatt ctttgggatg catctttatc ttcagcaagt aatgacaccc     1380

attcttctgt taagctcacc tggggaactt atcagcagtt gctgaaacag aaatgctggc     1440

agaatggccg agtacccaag cctgaatcgg gttgtactga aatacatcat catgagtggt     1500

ccaagatggc actctttgat tttttgttac agatttataa tcgcttagat acaaattgct     1560

gtggattcag acctcgcaag gaagatgcct gtgtacagaa tggattgagg ccaaaatgtg     1620

atgaccaagg ttctgcggct ctagcacaca ttatccagcg aaagcatgac ccaaggcatt     1680

tggtttttat agacaacaag ggtttctttg acaggagtga agataactta aacttcaaat     1740

tgttagaagg catcaaagag tttccagctt ctgcagtttc tgttttgaag agccagcact     1800

tacggcagaa acttcttcag tctctgtttc ttgataaagt gtattgggaa agtcaaggag     1860

gtagacaagg aattgaaaag cttatcgatg taatagaaca cagagccaaa attcttatca     1920

cctatatcaa tgcacacggg gtcaaagtat tacctatgaa tgaatgacaa aagaatcttc     1980

tggctagggt gttagatata tttatgcatt tttggttttg tttttaaatc aagcacatca     2040

acctcaagcc cgtttagcaa tgaggcagtg tagatgaata cgtaaaataa atgactttaa     2100

ccaagtagct ataatgggac ttagcactgt atgcatactt aaaaaggttt tgaaaaacaa     2160

actacttgag aaatatttgt ttatattttt ctctaacatc atgctatgtg tcagtctgaa     2220

catctgacaa cagaaatttc agttattatt ctagctaagt tttgaaaaca tttgtcatgc     2280

tgtttaatag aaaactgcaa accagagaca ctgactccat taataaacca tattttgtgc     2340

cgttttgact gttctgacca aatactaatg ggaacaattc ttgacgtttt tctgttgctg     2400

attgttaaca tagagcagtc tctacactac cctgaggcaa ctctacattg gaacactgag     2460

gcttacagcc tgcaagagca tcagagctga ccatacattt aaacagaaat gctggtttat     2520

ttgcaaaatc accagtatat tttctattgt gtctataaaa aatcagtcat ttaagtacaa     2580

gaatcatatt ttccattcct ttttagaaat ttattttgtt gtccctatgg aaatcattca     2640

catctgacaa tttatatgtt aaagagtttt actctctcta ttttggtcca atttgtatct     2700

agtggctgag aaattaaata attctaaagt atgaagttac ctatctgaaa atgtacttac     2760

agagtatcat tttaaaatgg atgtctcttt aaaaattttg ttacttttac caacaatgta     2820

atataattta tgtatatttt attaataata gtgaattcct taaaatttgt tctatgtact     2880

tatatttaat ttgatttaat ggttactgcc cagatattga gaattggttc aaatattgag     2940

tgtgtttcaa tatattatct ggcttatttc aacatgagta atatgagcaa aataagttaa     3000

aacctgcgtc tgatcaattt tcctcatgac tagaactaaa acagtaaatt tggacaatat     3060

taagcctcaa ataatcatct ccaaactcct tctaacactt tttaaatcag attggaagac     3120

atggacaaat caggttcatg tgttgcatct ttatgtcctt tgccaatatc caagatcatc     3180

acatatggta gatattcaca tggagtttca aattcagaat agattaccat taccttcctg     3240

cccttacaca tcctactcct tatttaaaag ttctatttgt gacttttcat ttcctgaaag     3300

tttaaaaata caatttgaga atgtttataa tacattctct cctgtctttt cacggttacg     3360

tctgttattg ctgaaataca ccacattttc tttgttctgg tcaaggttaa ctcaatatct     3420

gtgtgaaaga gaactactaa caacgttaca atagaggcta gatttgaaaa aaaaaatcta     3480

tagatctaat tgatacaatt gtagaacaaa atgtcaaaat aatgttttaa gtataagaga     3540

agatggacca aggagagaga gatcatttga aaatctaatt gtagcttttc taggctcaca     3600

ttcatgtact acttttagca cccttatggg ctgtgctcgc cccctggaca gttgagcttt     3660

ggattatctt cctcttcaat tttccctcta ttgacccgag tgtctccctc tgcttctaca     3720

gatttatagt actccttggc tcttttgagt ctccactttt actcactgtc tctgggattt     3780

ttaagatcct tttcttctct tataaatcat cctcttaatg aaaattagcc taacaaaagt     3840

ttggagactg gaatcctact ttgagccact gacttgaaat aactcttttg gcaagttgcc     3900

tgacatcctg tcttaccaag gtggcatatt tgcattttta ctgcttaaaa catttttttt     3960

tttttaccat ctttatccaa atttatcata ttgatggtag gactaacagg ctttttagaa     4020

gctggcttta actttgagtc tcaagctaca atgctgttgg gcagcctggt cttcccacgt     4080

gagggtttaa ctttgtttat ttgcctccag ttattccaaa atgcttatta aatgaaagtc     4140

ccaggaacat gtttatttta gtcacctttg ctttttaaca attttgtttt gtaatcaatg     4200

agtaattcat gatgaattat ttttgactaa tggatagccg aaggccaggc ttttaattct     4260

aataggtaat gttcttcttt tgtcttattg aaacaatgag aatactctgt gcatttcaaa     4320

tgcactccga ttatgctgtg gttttattca cataagcaca atatgtgttt tatttataac     4380

ttcataacaa acttataata taataattta ccttagcaga catgcaaaag cttattcttg     4440

tgtgacttac tttctttaag ctaataatat aaaaataaat atgtatctta aaaatctata     4500

ataaaacatt agaaattaaa gatatgtgct ttttattttg cagatgagtt catttgcttt     4560

tgtagatgtg ttttcagagc taggtacaga ggaatgtttg ctacctttag cggtgaaaaa     4620

agaaagagag tcaagaattt tgttggattg tgtttgtgtg tgcatatatt tgatatcatc     4680

attatatttg taatctttgg acttgtaatc atagcctgtt tattctactg tgccattaaa     4740

tatactttac cttatacata acgaataaaa tacctagaag tagatttatt tacaaaaaaa     4800

aaaaaaaaa                                                             4809


<210>  344
<211>  519
<212>  PRT
<213>  Homo Sapiens

<400>  344

Met Thr Cys Pro Asp Lys Pro Gly Gln Leu Ile Asn Trp Phe Ile Cys 
1               5                   10                  15      


Ser Leu Cys Val Pro Arg Val Arg Lys Leu Trp Ser Ser Arg Arg Pro 
            20                  25                  30          


Arg Thr Arg Arg Asn Leu Leu Leu Gly Thr Ala Cys Ala Ile Tyr Leu 
        35                  40                  45              


Gly Phe Leu Val Ser Gln Val Gly Arg Ala Ser Leu Gln His Gly Gln 
    50                  55                  60                  


Ala Ala Glu Lys Gly Pro His Arg Ser Arg Asp Thr Ala Glu Pro Ser 
65                  70                  75                  80  


Phe Pro Glu Ile Pro Leu Asp Gly Thr Leu Ala Pro Pro Glu Ser Gln 
                85                  90                  95      


Gly Asn Gly Ser Thr Leu Gln Pro Asn Val Val Tyr Ile Thr Leu Arg 
            100                 105                 110         


Ser Lys Arg Ser Lys Pro Ala Asn Ile Arg Gly Thr Val Lys Pro Lys 
        115                 120                 125             


Arg Arg Lys Lys His Ala Val Ala Ser Ala Ala Pro Gly Gln Glu Ala 
    130                 135                 140                 


Leu Val Gly Pro Ser Leu Gln Pro Gln Glu Ala Ala Arg Glu Ala Asp 
145                 150                 155                 160 


Ala Val Ala Pro Gly Tyr Ala Gln Gly Ala Asn Leu Val Lys Ile Gly 
                165                 170                 175     


Glu Arg Pro Trp Arg Leu Val Arg Gly Pro Gly Val Arg Ala Gly Gly 
            180                 185                 190         


Pro Asp Phe Leu Gln Pro Ser Ser Arg Glu Ser Asn Ile Arg Ile Tyr 
        195                 200                 205             


Ser Glu Ser Ala Pro Ser Trp Leu Ser Lys Asp Asp Ile Arg Arg Met 
    210                 215                 220                 


Arg Leu Leu Ala Asp Ser Ala Val Ala Gly Leu Arg Pro Val Ser Ser 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Leu Leu Val Leu Glu Gly Gly Ala Pro Gly Ala 
                245                 250                 255     


Val Leu Arg Cys Gly Pro Ser Pro Cys Gly Leu Leu Lys Gln Pro Leu 
            260                 265                 270         


Asp Met Ser Glu Val Phe Ala Phe His Leu Asp Arg Ile Leu Gly Leu 
        275                 280                 285             


Asn Arg Thr Leu Pro Ser Val Ser Arg Lys Ala Glu Phe Ile Gln Asp 
    290                 295                 300                 


Gly Arg Pro Cys Pro Ile Ile Leu Trp Asp Ala Ser Leu Ser Ser Ala 
305                 310                 315                 320 


Ser Asn Asp Thr His Ser Ser Val Lys Leu Thr Trp Gly Thr Tyr Gln 
                325                 330                 335     


Gln Leu Leu Lys Gln Lys Cys Trp Gln Asn Gly Arg Val Pro Lys Pro 
            340                 345                 350         


Glu Ser Gly Cys Thr Glu Ile His His His Glu Trp Ser Lys Met Ala 
        355                 360                 365             


Leu Phe Asp Phe Leu Leu Gln Ile Tyr Asn Arg Leu Asp Thr Asn Cys 
    370                 375                 380                 


Cys Gly Phe Arg Pro Arg Lys Glu Asp Ala Cys Val Gln Asn Gly Leu 
385                 390                 395                 400 


Arg Pro Lys Cys Asp Asp Gln Gly Ser Ala Ala Leu Ala His Ile Ile 
                405                 410                 415     


Gln Arg Lys His Asp Pro Arg His Leu Val Phe Ile Asp Asn Lys Gly 
            420                 425                 430         


Phe Phe Asp Arg Ser Glu Asp Asn Leu Asn Phe Lys Leu Leu Glu Gly 
        435                 440                 445             


Ile Lys Glu Phe Pro Ala Ser Ala Val Ser Val Leu Lys Ser Gln His 
    450                 455                 460                 


Leu Arg Gln Lys Leu Leu Gln Ser Leu Phe Leu Asp Lys Val Tyr Trp 
465                 470                 475                 480 


Glu Ser Gln Gly Gly Arg Gln Gly Ile Glu Lys Leu Ile Asp Val Ile 
                485                 490                 495     


Glu His Arg Ala Lys Ile Leu Ile Thr Tyr Ile Asn Ala His Gly Val 
            500                 505                 510         


Lys Val Leu Pro Met Asn Glu 
        515                 


<210>  345
<211>  1815
<212>  DNA
<213>  Homo Sapiens

<400>  345
cttagctgaa gatgactgac agtgttattt attccatgtt agagttgcct acggcaaccc       60

aagcccagaa tgactatgga ccacagcaaa aatcttcctc ttccaggcct tcttgttctt      120

gccttgtggc aatagctttg gggcttctga ctgcagttct tctgagtgtg ctgctatacc      180

agtggatcct gtgccagggc tccaactact ccacttgtgc cagctgtcct agctgcccag      240

accgctggat gaaatatggt aaccattgtt attatttctc agtggaggaa aaggactgga      300

attctagtct ggaattctgc ctagccagag actcacacct ccttgtgata acggacaatc      360

aggaaatgag cctgctccaa gttttcctca gtgaggcctt ttgctggatt ggtctgagga      420

acaattctgg ctggaggtgg gaagatggat cacctctaaa cttctcaagg atttcttcta      480

atagctttgt gcagacatgc ggtgccatca acaaaaatgg tcttcaagcc tcaagctgtg      540

aagttccttt acactgggtg tgtaagaagg tcagactttg atagatgacc actctgtcct      600

gaccctcaga tctgtcatgt atccctaaaa ggagggagct ggccactggc tgttgggaaa      660

gccatgagta tatagttagc aaatactgaa ctttctcaga tatggcatta gatgcaagac      720

aacctcctag ggattgatgc ctaactgatg gattctcttt gagactattt agatattatg      780

tgagcaattt aaagaccaga tctaagcaaa ttttgaaata gatgtttgtt ttttgtattt      840

ctcagtatgg aaactaatgc tgccactctc atccccgtcc caaccatctc tgtcaaaaat      900

ataccttttt catatgatat tctgagctaa tctgataaaa tctatgccaa tatatactat      960

tgcttgtgta ctagagaagt acattattgc tgtactcctc tgtacattac tgatccctga     1020

tggtatattt ctatcctaac agtgtccctt tgcagatcaa gctttattct gaagaataaa     1080

cctagctggc atgctggtgt gtacctgtag tcctagctat ttgggaagct gaggtgggag     1140

ggtcgcttga gcccaggagt ttgaggctgc agtgagctat gattgtgcca ctgtactcca     1200

gcctgggaga tagagcaaga ctccatctct aaaaaaaaaa aaaaatgcta atgtgagaat     1260

ataaattgtg ggaaatgagt gagggcaagg tggtacttcc tccttctgag ctcttcacac     1320

gtaatgcaaa aacccggtct taactgattt tgtttttttt ctgagtatgc atatatgtgg     1380

ttgaatgaac caatgtgtga ttgtatcttt tccattatgt gactgtttga cctgcatatt     1440

aatttcaaga tagcagtcaa ttcgataagg cattttcata gaggaaagtt tacagaaaca     1500

gtttatgtgg ttggatcacc aaattatctt aggtactaag gcctcaaaaa taagaaaaac     1560

tttattattt ctcctcagta gagtttggac atacataagg agagaaggta cagtgatgaa     1620

ggagaccata attctgtagt gttgatgatc ctggattata atctttttct ctttatcttt     1680

catagttttt ttaaaaacat ggactgtatc ttatctacca ctatatccca aatacctaag     1740

atagtgctta cgttcagtga ctattaaata aataaatgga tgaattaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaa                                                      1815


<210>  346
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  346

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu 
            180                 185                 


<210>  347
<211>  2799
<212>  DNA
<213>  Homo Sapiens

<400>  347
attggctgcc cggccccctt tgttcccggg tccgggccgc aggcccgctg cggcggactg       60

ggcggcggaa gttcgacggc gccgggcgag tggctgttga gcggcgccgc gggagttccg      120

caggtttccc gtgttcgcag cggagccgga ggccagctga acccggccgt gggatcccgg      180

ataggaggag gaggggaccc ataggacgcg ttaacatgga cctggaaaac aaagtgaaga      240

agatgggctt aggtcacgag caaggatttg gagccccttg tttaaaatgc aaagaaaaat      300

gtgaaggatt cgaactgcac ttctggagaa aaatatgtcg taactgcaag tgtggccaag      360

aagagcatga tgtcctcttg agcaatgaag aggatcgaaa agtgggaaaa ctttttgaag      420

acaccaagta taccactctg attgcaaaac taaagtcaga tggaattccc atgtataaac      480

gcaatgttat gatattgacg aatccagttg ctgccaagaa gaatgtctcc atcaatacag      540

ttacctatga gtgggctcct cctgtccaga atcaagcatt ggccaggcag tacatgcaga      600

tgctacccaa ggaaaagcag ccagtagcag gctcagaggg ggcacagtac cggaagaagc      660

agctggcaaa gcagctccct gcacatgacc aggacccttc aaagtgccat gagttgtctc      720

ccagagaggt gaaggagatg gagcagtttg tgaagaaata taagagcgaa gctctgggag      780

taggagatgt caaacttccc tgtgagatgg atgcccaagg ccccaaacaa atgaacattc      840

ctggagggga tagaagcacc ccagcagcag tgggggccat ggaggacaaa tctgctgagc      900

acaaaagaac tcaatattcc tgctattgct gcaaactgag tatgaaagaa ggtgacccag      960

ccatctatgc cgaaagggct ggctatgata aactgtggca cccagcttgt tttgtctgca     1020

gcacctgcca tgaactcctg gttgacatga tttatttttg gaagaatgag aagctatact     1080

gtggcagaca ttactgtgac agcgagaaac cccgatgtgc tggctgtgac gagctgatat     1140

tcagcaatga gtatacccag gcagaaaacc agaattggca cctgaaacac ttctgctgct     1200

ttgactgtga tagcattcta gctggggaga tatacgtgat ggtcaatgac aagcccgtgt     1260

gcaagccctg ctatgtgaag aatcacgctg tggtgtgtca aggatgccac aatgccatcg     1320

acccagaagt gcagcgggtg acctataaca atttcagctg gcatgcatcc acagagtgct     1380

ttctgtgctc ttgctgcagc aaatgcctca ttgggcagaa gttcatgcca gtagaaggga     1440

tggttttctg ttcagtggaa tgtaagaaga ggatgtctta ggaggagggc acccagaagt     1500

atcgagccat agctatccaa agtggtctgc atttctactg taaaatgcaa tttgaaaaaa     1560

ataaaacgca aaaaaagaaa ctgtaaagga aaccaagaga ttttgtttaa tttttttggc     1620

cattttttct tcatcaattt tttttcggtc tcaactttta aacttggttt aagcatttga     1680

tttgtaaaac agtaaataat tgtatctttc catagctttt caaatgtgaa atcatttttg     1740

gaagcttgga tctcattaaa cttcatgtct ctattccatt tgtgccacac acttaaaagt     1800

tagtgtactg aatggaaaga tgagcattcc tagttctaca cttctttttt ccccctcatg     1860

tgtaaaatga aaagaaaact aaatttgccc taataccaag gcgctacgtt tattgcctcg     1920

tcttattcac tgacctttgt aatgatacac agtgaattct ttttgacaaa gagaaatgca     1980

gtgtagtatg cagagctgct gttttaatgc ctatgcattt actctttcct gatttaggca     2040

gaggtggcat tttctttatt gcatttctct atttttttaa tgtaccctac cttcagtatt     2100

ctctttgtaa gttggtgact tgcatctgtg gccttgaata ttttattatc acatgtggca     2160

taacagtatc cacacttttt agttctttat tttttttttt ttattttgag caattctcct     2220

gcctcagcct cccaaatagc tgggattaca ggtgcatgcc accacaccca gctaattttt     2280

gtatttttag tagagacagg ttttcaccat gttagccagg ctggtctcaa actcctgacc     2340

tcagatgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gggagccacc     2400

atgcctgacc cacacacttt ttacttgtat agatgatttt tggcttggac ataaaagcca     2460

agccacccat ttgcttttaa tccaaagaac atgtatagtt tttgtaccca gagactatga     2520

tttatattga ttgcacttgc ctgccatgat ttagataaga ttttttttgc atggttttta     2580

ttctttccta atggatcctg ttttataata cttccaagcc tgtccatgga tatatcaaat     2640

gtcttcactt gtatattttc atggctaggt atttctaatg tttattcttc cctgtgtact     2700

tctacacata gctatgcact atgaaaatta aatggaatga atgatatgta tattactcaa     2760

aataaagttt ctttcacttt aaaaaaaaaa aaaaaaaaa                            2799


<210>  348
<211>  421
<212>  PRT
<213>  Homo Sapiens

<400>  348

Met Asp Leu Glu Asn Lys Val Lys Lys Met Gly Leu Gly His Glu Gln 
1               5                   10                  15      


Gly Phe Gly Ala Pro Cys Leu Lys Cys Lys Glu Lys Cys Glu Gly Phe 
            20                  25                  30          


Glu Leu His Phe Trp Arg Lys Ile Cys Arg Asn Cys Lys Cys Gly Gln 
        35                  40                  45              


Glu Glu His Asp Val Leu Leu Ser Asn Glu Glu Asp Arg Lys Val Gly 
    50                  55                  60                  


Lys Leu Phe Glu Asp Thr Lys Tyr Thr Thr Leu Ile Ala Lys Leu Lys 
65                  70                  75                  80  


Ser Asp Gly Ile Pro Met Tyr Lys Arg Asn Val Met Ile Leu Thr Asn 
                85                  90                  95      


Pro Val Ala Ala Lys Lys Asn Val Ser Ile Asn Thr Val Thr Tyr Glu 
            100                 105                 110         


Trp Ala Pro Pro Val Gln Asn Gln Ala Leu Ala Arg Gln Tyr Met Gln 
        115                 120                 125             


Met Leu Pro Lys Glu Lys Gln Pro Val Ala Gly Ser Glu Gly Ala Gln 
    130                 135                 140                 


Tyr Arg Lys Lys Gln Leu Ala Lys Gln Leu Pro Ala His Asp Gln Asp 
145                 150                 155                 160 


Pro Ser Lys Cys His Glu Leu Ser Pro Arg Glu Val Lys Glu Met Glu 
                165                 170                 175     


Gln Phe Val Lys Lys Tyr Lys Ser Glu Ala Leu Gly Val Gly Asp Val 
            180                 185                 190         


Lys Leu Pro Cys Glu Met Asp Ala Gln Gly Pro Lys Gln Met Asn Ile 
        195                 200                 205             


Pro Gly Gly Asp Arg Ser Thr Pro Ala Ala Val Gly Ala Met Glu Asp 
    210                 215                 220                 


Lys Ser Ala Glu His Lys Arg Thr Gln Tyr Ser Cys Tyr Cys Cys Lys 
225                 230                 235                 240 


Leu Ser Met Lys Glu Gly Asp Pro Ala Ile Tyr Ala Glu Arg Ala Gly 
                245                 250                 255     


Tyr Asp Lys Leu Trp His Pro Ala Cys Phe Val Cys Ser Thr Cys His 
            260                 265                 270         


Glu Leu Leu Val Asp Met Ile Tyr Phe Trp Lys Asn Glu Lys Leu Tyr 
        275                 280                 285             


Cys Gly Arg His Tyr Cys Asp Ser Glu Lys Pro Arg Cys Ala Gly Cys 
    290                 295                 300                 


Asp Glu Leu Ile Phe Ser Asn Glu Tyr Thr Gln Ala Glu Asn Gln Asn 
305                 310                 315                 320 


Trp His Leu Lys His Phe Cys Cys Phe Asp Cys Asp Ser Ile Leu Ala 
                325                 330                 335     


Gly Glu Ile Tyr Val Met Val Asn Asp Lys Pro Val Cys Lys Pro Cys 
            340                 345                 350         


Tyr Val Lys Asn His Ala Val Val Cys Gln Gly Cys His Asn Ala Ile 
        355                 360                 365             


Asp Pro Glu Val Gln Arg Val Thr Tyr Asn Asn Phe Ser Trp His Ala 
    370                 375                 380                 


Ser Thr Glu Cys Phe Leu Cys Ser Cys Cys Ser Lys Cys Leu Ile Gly 
385                 390                 395                 400 


Gln Lys Phe Met Pro Val Glu Gly Met Val Phe Cys Ser Val Glu Cys 
                405                 410                 415     


Lys Lys Arg Met Ser 
            420     


<210>  349
<211>  5296
<212>  DNA
<213>  Homo Sapiens

<400>  349
ctgctggagt aggcacccat ttaaagaaaa aatgaagaag cagcaataaa gaagttgtaa       60

tcgttaccta gacaaacaga gaactggttt tgacagtgtt tctagagtgc tttttattat      120

tttcctgaca gttgtgttcc accatgatta ctttctcctt cagcgaatag gctaaatgaa      180

tatgaaacag aaaagcgtgt atcagcaaac caaagcactt ctgtgcaaga attttcttaa      240

gaaatggagg atgaaaagag agagcttatt ggaatggggc ctctcaatac ttctaggact      300

gtgtattgct ctgttttcca gttccatgag aaatgtccag tttcctggaa tggctcctca      360

gaatctggga agggtagata aatttaatag ctcttcttta atggttgtgt atacaccaat      420

atctaattta acccagcaga taatgaataa aacagcactt gctcctcttt tgaaaggaac      480

aagtgtcatt ggggcaccaa ataaaacaca catggacgaa atacttctgg aaaatttacc      540

atatgctatg ggaatcatct ttaatgaaac tttctcttat aagttaatat ttttccaggg      600

atataacagt ccactttgga aagaagattt ctcagctcat tgctgggatg gatatggtga      660

gttttcatgt acattgacca aatactggaa tagaggattt gtggctttac aaacagctat      720

taatactgcc attatagaaa tcacaaccaa tcaccctgtg atggaggagt tgatgtcagt      780

tactgctata actatgaaga cattaccttt cataactaaa aatcttcttc acaatgagat      840

gtttatttta ttcttcttgc ttcatttctc cccacttgta tattttatat cactcaatgt      900

aacaaaagag agaaaaaagt ctaagaattt gatgaaaatg atgggtctcc aagattcagc      960

attctggctc tcctggggtc taatctatgc tggcttcatc tttattattt ccatattcgt     1020

tacaattatc ataacattca cccaaattat agtcatgact ggcttcatgg tcatatttat     1080

actctttttt ttatatggct tatctttggt agctttggtg ttcctgatga gtgtgctgtt     1140

aaagaaagct gtcctcacca atttggttgt gtttctcctt accctctttt ggggatgtct     1200

gggattcact gtattttatg aacaacttcc ttcatctctg gagtggattt tgaatatttg     1260

tagccctttt gcctttacta ctggaatgat tcagattatc aaactggatt ataacttgaa     1320

tggtgtaatt tttcctgacc cttcaggaga ctcatataca atgatagcaa ctttttctat     1380

gttgcttttg gatggtctca tctacttgct attggcatta tactttgaca aaattttacc     1440

ctatggagat gagcgccatt attctccttt atttttcttg aattcatcat cttgtttcca     1500

acaccaaagg actaatgcta aggttattga gaaagaaatc gatgctgagc atccctctga     1560

tgattatttt gaaccagtag ctcctgaatt ccaaggaaaa gaagccatca gaatcagaaa     1620

tgttaagaag gaatataaag gaaaatctgg aaaagtggaa gcattgaaag gcttgctctt     1680

tgacatatat gaaggtcaaa tcacggcaat cctgggtcac agtggagctg gcaaatcttc     1740

actgctaaat attcttaatg gattgtctgt tccaacagaa ggatcagtta ccatctataa     1800

taaaaatctc tctgaaatgc aagacttgga ggaaatcaga aagataactg gcgtctgtcc     1860

tcaattcaat gttcaatttg acatactcac cgtgaaggaa aacctcagcc tgtttgctaa     1920

aataaaaggg attcatctaa aggaagtgga acaagaggta caacgaatat tattggaatt     1980

ggacatgcaa aacattcaag ataaccttgc taaacattta agtgaaggac agaaaagaaa     2040

gctgactttt gggattacca ttttaggaga tcctcaaatt ttgcttttag atgaaccaac     2100

tactggattg gatccctttt ccagagatca agtgtggagc ctcctgagag agcgtagagc     2160

agatcatgtg atccttttca gtacccagtc catggatgag gctgacatcc tggctgatag     2220

aaaagtgatc atgtccaatg ggagactgaa gtgtgcaggt tcttctatgt ttttgaaaag     2280

aaggtggggt cttggatatc acctaagttt acataggaat gaaatatgta acccagaaca     2340

aataacatcc ttcattactc atcacatccc cgatgctaaa ttaaaaacag aaaacaaaga     2400

aaagcttgta tatactttgc cactggaaag gacaaataca tttccagatc ttttcagtga     2460

tctggataag tgttctgacc agggagtgac aggttatgac atttccatgt caactctaaa     2520

tgaagtcttt atgaaactgg aaggacagtc aactatcgaa caagatttcg aacaagtgga     2580

gatgataaga gactcagaaa gcctcaatga aatggagctg gctcactctt ccttctctga     2640

aatgcagaca gctgtgagtg acatgggcct ctggagaatg caagtctttg ccatggcacg     2700

gctccgtttc ttaaagttaa aacgtcaaac taaagtgtta ttgaccctat tattggtatt     2760

tggaatcgca atattccctt tgattgttga aaatataatg tatgctatgt taaatgaaaa     2820

gatcgattgg gaatttaaaa acgaattgta ttttctctct cctggacaac ttccccagga     2880

accccgtacc agcctgttga tcatcaataa cacagaatca aatattgaag attttataaa     2940

atcactgaag catcaaaata tacttttgga agtagatgac tttgaaaaca gaaatggtac     3000

tgatggcctc tcatacaatg gagctatcat agtttctggt aaacaaaagg attatagatt     3060

ttcagttgtg tgtaatacca agagattgca ctgttttcca attcttatga atattatcag     3120

caatgggcta cttcaaatgt ttaatcacac acaacatatt cgaattgagt caagcccatt     3180

tcctcttagc cacataggac tctggactgg gttgccggat ggttcctttt tcttattttt     3240

ggttctatgt agcatttctc cttatatcac catgggcagc atcagtgatt acaagaaaaa     3300

tgctaagtcc cagctatgga tttcaggcct ctacacttct gcttactggt gtgggcaggc     3360

actagtggac gtcagcttct tcattttaat tctcctttta atgtatttaa ttttctacat     3420

agaaaacatg cagtaccttc ttattacaag ccaaattgtg tttgctttgg ttatagttac     3480

tcctggttat gcagcttctc ttgtcttctt catatatatg atatcattta tttttcgcaa     3540

aaggagaaaa aacagtggcc tttggtcatt ttacttcttt tttgcctcca ccatcatgtt     3600

ttccatcact ttaatcaatc attttgacct aagtatattg attaccacca tggtattggt     3660

tccttcatat accttgcttg gatttaaaac ttttttggaa gtgagagacc aggagcacta     3720

cagagaattt ccagaggcaa attttgaatt gagtgccact gattttctag tctgcttcat     3780

accctacttt cagactttgc tattcgtttt tgttctaaga tgcatggaac taaaatgtgg     3840

aaagaaaaga atgcgaaaag atcctgtttt cagaatttcc ccccaaagta gagatgctaa     3900

gccaaatcca gaagaaccca tagatgaaga tgaagatatt caaacagaaa gaataagaac     3960

agccactgct ctgaccactt caatcttaga tgagaaacct gttataattg ccagctgtct     4020

acacaaagaa tatgcaggcc agaagaaaag ttgcttttca aagaggaaga agaaaatagc     4080

agcaagaaat atctctttct gtgttcaaga aggtgaaatt ttgggattgc taggacccaa     4140

tggtgctgga aaaagttcat ctattagaat gatatctggg atcacaaagc caactgctgg     4200

agaggtggaa ctgaaaggct gcagttcagt tttgggccac ctggggtact gccctcaaga     4260

gaacgtgctg tggcccatgc tgacgttgag ggaacacctg gaggtgtatg ctgccgtcaa     4320

ggggctcagg aaagcggacg cgaggctcgc catcgcaaga ttagtgagtg ctttcaaact     4380

gcatgagcag ctgaatgttc ctgtgcagaa attaacagca ggaatcacga gaaagttgtg     4440

ttttgtgctg agcctcctgg gaaactcacc tgtcttgctc ctggatgaac catctacggg     4500

catagacccc acagggcagc agcaaatgtg gcaggcaatc caggcagtcg ttaaaaacac     4560

agagagaggt gtcctcctga ccacccataa cctggctgag gcggaagcct tgtgtgaccg     4620

tgtggccatc atggtgtctg gaaggcttag atgcattggc tccatccaac acctgaaaaa     4680

caaacttggc aaggattaca ttctagagct aaaagtgaag gaaacgtctc aagtgacttt     4740

ggtccacact gagattctga agcttttccc acaggctgca gggcaggaaa ggtattcctc     4800

tttgttaacc tataagctgc ccgtggcaga cgtttaccct ctatcacaga cctttcacaa     4860

attagaagca gtgaagcata actttaacct ggaagaatac agcctttctc agtgcacact     4920

ggagaaggta ttcttagagc tttctaaaga acaggaagta ggaaattttg atgaagaaat     4980

tgatacaaca atgagatgga aactcctccc tcattcagat gaaccttaaa acctcaaacc     5040

tagtaatttt ttgttgatct cctataaact catgttttat gtaataatta atagtatgtt     5100

taattttaaa gatcatttaa aattaacatc aggtatattt tgtaaattta gttaacaaat     5160

acataaattt taaaattatt cttcctctca aacatagggg tgatagcaaa cctgtgataa     5220

aggcaataca aaatattagt aaagtcaccc aaagagtcag gcactgggta ttgtggaaat     5280

aaaactatat aaactt                                                     5296


<210>  350
<211>  1617
<212>  PRT
<213>  Homo Sapiens

<400>  350

Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu 
            20                  25                  30          


Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser 
        35                  40                  45              


Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu 
    50                  55                  60                  


Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr 
65                  70                  75                  80  


Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala 
                85                  90                  95      


Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His 
            100                 105                 110         


Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile 
        115                 120                 125             


Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn 
    130                 135                 140                 


Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr 
145                 150                 155                 160 


Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val 
                165                 170                 175     


Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn 
            180                 185                 190         


His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys 
        195                 200                 205             


Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile 
    210                 215                 220                 


Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu 
225                 230                 235                 240 


Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met 
                245                 250                 255     


Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala 
            260                 265                 270         


Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe 
        275                 280                 285             


Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe 
    290                 295                 300                 


Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val 
305                 310                 315                 320 


Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr 
                325                 330                 335     


Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro 
            340                 345                 350         


Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr 
        355                 360                 365             


Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val 
    370                 375                 380                 


Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe 
385                 390                 395                 400 


Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr 
                405                 410                 415     


Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu 
            420                 425                 430         


Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala 
        435                 440                 445             


Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr 
    450                 455                 460                 


Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala 
                485                 490                 495     


Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile 
            500                 505                 510         


Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn 
        515                 520                 525             


Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn 
    530                 535                 540                 


Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val 
545                 550                 555                 560 


Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn 
                565                 570                 575     


Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu 
            580                 585                 590         


Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln 
        595                 600                 605             


Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr 
    610                 615                 620                 


Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Thr Gly Leu Asp Pro Phe Ser Arg Asp Gln Val Trp Ser Leu 
                645                 650                 655     


Leu Arg Glu Arg Arg Ala Asp His Val Ile Leu Phe Ser Thr Gln Ser 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Ile Met Ser Asn 
        675                 680                 685             


Gly Arg Leu Lys Cys Ala Gly Ser Ser Met Phe Leu Lys Arg Arg Trp 
    690                 695                 700                 


Gly Leu Gly Tyr His Leu Ser Leu His Arg Asn Glu Ile Cys Asn Pro 
705                 710                 715                 720 


Glu Gln Ile Thr Ser Phe Ile Thr His His Ile Pro Asp Ala Lys Leu 
                725                 730                 735     


Lys Thr Glu Asn Lys Glu Lys Leu Val Tyr Thr Leu Pro Leu Glu Arg 
            740                 745                 750         


Thr Asn Thr Phe Pro Asp Leu Phe Ser Asp Leu Asp Lys Cys Ser Asp 
        755                 760                 765             


Gln Gly Val Thr Gly Tyr Asp Ile Ser Met Ser Thr Leu Asn Glu Val 
    770                 775                 780                 


Phe Met Lys Leu Glu Gly Gln Ser Thr Ile Glu Gln Asp Phe Glu Gln 
785                 790                 795                 800 


Val Glu Met Ile Arg Asp Ser Glu Ser Leu Asn Glu Met Glu Leu Ala 
                805                 810                 815     


His Ser Ser Phe Ser Glu Met Gln Thr Ala Val Ser Asp Met Gly Leu 
            820                 825                 830         


Trp Arg Met Gln Val Phe Ala Met Ala Arg Leu Arg Phe Leu Lys Leu 
        835                 840                 845             


Lys Arg Gln Thr Lys Val Leu Leu Thr Leu Leu Leu Val Phe Gly Ile 
    850                 855                 860                 


Ala Ile Phe Pro Leu Ile Val Glu Asn Ile Met Tyr Ala Met Leu Asn 
865                 870                 875                 880 


Glu Lys Ile Asp Trp Glu Phe Lys Asn Glu Leu Tyr Phe Leu Ser Pro 
                885                 890                 895     


Gly Gln Leu Pro Gln Glu Pro Arg Thr Ser Leu Leu Ile Ile Asn Asn 
            900                 905                 910         


Thr Glu Ser Asn Ile Glu Asp Phe Ile Lys Ser Leu Lys His Gln Asn 
        915                 920                 925             


Ile Leu Leu Glu Val Asp Asp Phe Glu Asn Arg Asn Gly Thr Asp Gly 
    930                 935                 940                 


Leu Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Lys Gln Lys Asp Tyr 
945                 950                 955                 960 


Arg Phe Ser Val Val Cys Asn Thr Lys Arg Leu His Cys Phe Pro Ile 
                965                 970                 975     


Leu Met Asn Ile Ile Ser Asn Gly Leu Leu Gln Met Phe Asn His Thr 
            980                 985                 990         


Gln His Ile Arg Ile Glu Ser Ser  Pro Phe Pro Leu Ser  His Ile Gly 
        995                 1000                 1005             


Leu Trp  Thr Gly Leu Pro Asp  Gly Ser Phe Phe Leu  Phe Leu Val 
    1010                 1015                 1020             


Leu Cys  Ser Ile Ser Pro Tyr  Ile Thr Met Gly Ser  Ile Ser Asp 
    1025                 1030                 1035             


Tyr Lys  Lys Asn Ala Lys Ser  Gln Leu Trp Ile Ser  Gly Leu Tyr 
    1040                 1045                 1050             


Thr Ser  Ala Tyr Trp Cys Gly  Gln Ala Leu Val Asp  Val Ser Phe 
    1055                 1060                 1065             


Phe Ile  Leu Ile Leu Leu Leu  Met Tyr Leu Ile Phe  Tyr Ile Glu 
    1070                 1075                 1080             


Asn Met  Gln Tyr Leu Leu Ile  Thr Ser Gln Ile Val  Phe Ala Leu 
    1085                 1090                 1095             


Val Ile  Val Thr Pro Gly Tyr  Ala Ala Ser Leu Val  Phe Phe Ile 
    1100                 1105                 1110             


Tyr Met  Ile Ser Phe Ile Phe  Arg Lys Arg Arg Lys  Asn Ser Gly 
    1115                 1120                 1125             


Leu Trp  Ser Phe Tyr Phe Phe  Phe Ala Ser Thr Ile  Met Phe Ser 
    1130                 1135                 1140             


Ile Thr  Leu Ile Asn His Phe  Asp Leu Ser Ile Leu  Ile Thr Thr 
    1145                 1150                 1155             


Met Val  Leu Val Pro Ser Tyr  Thr Leu Leu Gly Phe  Lys Thr Phe 
    1160                 1165                 1170             


Leu Glu  Val Arg Asp Gln Glu  His Tyr Arg Glu Phe  Pro Glu Ala 
    1175                 1180                 1185             


Asn Phe  Glu Leu Ser Ala Thr  Asp Phe Leu Val Cys  Phe Ile Pro 
    1190                 1195                 1200             


Tyr Phe  Gln Thr Leu Leu Phe  Val Phe Val Leu Arg  Cys Met Glu 
    1205                 1210                 1215             


Leu Lys  Cys Gly Lys Lys Arg  Met Arg Lys Asp Pro  Val Phe Arg 
    1220                 1225                 1230             


Ile Ser  Pro Gln Ser Arg Asp  Ala Lys Pro Asn Pro  Glu Glu Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asp Glu Asp Ile  Gln Thr Glu Arg Ile  Arg Thr Ala 
    1250                 1255                 1260             


Thr Ala  Leu Thr Thr Ser Ile  Leu Asp Glu Lys Pro  Val Ile Ile 
    1265                 1270                 1275             


Ala Ser  Cys Leu His Lys Glu  Tyr Ala Gly Gln Lys  Lys Ser Cys 
    1280                 1285                 1290             


Phe Ser  Lys Arg Lys Lys Lys  Ile Ala Ala Arg Asn  Ile Ser Phe 
    1295                 1300                 1305             


Cys Val  Gln Glu Gly Glu Ile  Leu Gly Leu Leu Gly  Pro Asn Gly 
    1310                 1315                 1320             


Ala Gly  Lys Ser Ser Ser Ile  Arg Met Ile Ser Gly  Ile Thr Lys 
    1325                 1330                 1335             


Pro Thr  Ala Gly Glu Val Glu  Leu Lys Gly Cys Ser  Ser Val Leu 
    1340                 1345                 1350             


Gly His  Leu Gly Tyr Cys Pro  Gln Glu Asn Val Leu  Trp Pro Met 
    1355                 1360                 1365             


Leu Thr  Leu Arg Glu His Leu  Glu Val Tyr Ala Ala  Val Lys Gly 
    1370                 1375                 1380             


Leu Arg  Lys Ala Asp Ala Arg  Leu Ala Ile Ala Arg  Leu Val Ser 
    1385                 1390                 1395             


Ala Phe  Lys Leu His Glu Gln  Leu Asn Val Pro Val  Gln Lys Leu 
    1400                 1405                 1410             


Thr Ala  Gly Ile Thr Arg Lys  Leu Cys Phe Val Leu  Ser Leu Leu 
    1415                 1420                 1425             


Gly Asn  Ser Pro Val Leu Leu  Leu Asp Glu Pro Ser  Thr Gly Ile 
    1430                 1435                 1440             


Asp Pro  Thr Gly Gln Gln Gln  Met Trp Gln Ala Ile  Gln Ala Val 
    1445                 1450                 1455             


Val Lys  Asn Thr Glu Arg Gly  Val Leu Leu Thr Thr  His Asn Leu 
    1460                 1465                 1470             


Ala Glu  Ala Glu Ala Leu Cys  Asp Arg Val Ala Ile  Met Val Ser 
    1475                 1480                 1485             


Gly Arg  Leu Arg Cys Ile Gly  Ser Ile Gln His Leu  Lys Asn Lys 
    1490                 1495                 1500             


Leu Gly  Lys Asp Tyr Ile Leu  Glu Leu Lys Val Lys  Glu Thr Ser 
    1505                 1510                 1515             


Gln Val  Thr Leu Val His Thr  Glu Ile Leu Lys Leu  Phe Pro Gln 
    1520                 1525                 1530             


Ala Ala  Gly Gln Glu Arg Tyr  Ser Ser Leu Leu Thr  Tyr Lys Leu 
    1535                 1540                 1545             


Pro Val  Ala Asp Val Tyr Pro  Leu Ser Gln Thr Phe  His Lys Leu 
    1550                 1555                 1560             


Glu Ala  Val Lys His Asn Phe  Asn Leu Glu Glu Tyr  Ser Leu Ser 
    1565                 1570                 1575             


Gln Cys  Thr Leu Glu Lys Val  Phe Leu Glu Leu Ser  Lys Glu Gln 
    1580                 1585                 1590             


Glu Val  Gly Asn Phe Asp Glu  Glu Ile Asp Thr Thr  Met Arg Trp 
    1595                 1600                 1605             


Lys Leu  Leu Pro His Ser Asp  Glu Pro 
    1610                 1615         


<210>  351
<211>  4481
<212>  DNA
<213>  Homo Sapiens

<400>  351
ttcctgtcta cgtttcattt cctgggggct tgccaagtga taaacagacc caggcgtgtg       60

tggtagagtt cgggtttttt agcacgaagt gggtggctgg agtttgcttg aaaacatcaa      120

ttgactttgt gatcattaca gaaatgctgg tgtaaggtgt tcagaagaca atggagaaaa      180

aatggaaata ctgtgctgtc tattacatca tccagataca ttttgtcaag ggagtttggg      240

aaaaaacagt caacacagaa gaaaatgttt atgctacact tggctctgat gtcaacctga      300

cctgccaaac acagacagta ggcttcttcg tgcagatgca atggtccaag gtcaccaata      360

agatagacct gattgctgtc tatcatcccc aatacggctt ctactgtgcc tatgggagac      420

cctgtgagtc acttgtgact ttcacagaaa ctcctgagaa tgggtcaaaa tggactctgc      480

acttaaggaa tatgtcttgt tcagtcagtg gaaggtacga gtgtatgctt gttctgtatc      540

cagagggcat tcagactaaa atctacaacc ttctcattca gacacacgtt acagcagatg      600

aatggaacag caaccatacg atagaaatag agataaatca gactctggaa ataccatgct      660

ttcaaaatag ctcctcaaaa atttcatctg agttcaccta tgcatggtcg gtggaaaaca      720

gcagcacgga ttcttgggtc cttctttcta agggtataaa ggaggataat ggaactcagg      780

aaacacttat ctcccaaaat cacctcatca gcaattccac attacttaaa gatagagtca      840

agcttggtac agactacaga ctccacctct ctccagtcca aatcttcgat gatgggcgga      900

agttctcttg ccacattaga gtcggtccta acaaaatctt gaggagctcc accacagtca      960

aggtttttgc taaaccagaa atccctgtga ttgtggaaaa taactccacg gatgtcttgg     1020

tagagagaag atttacctgc ttactaaaga atgtatttcc caaagcaaat atcacatggt     1080

ttatagatgg aagttttctt catgatgaaa aagaaggaat atatattact aatgaagaga     1140

gaaaaggcaa agatggattt ttggaactga agtctgtttt aacaagggta catagtaata     1200

aaccagccca atcagacaac ttgaccattt ggtgtatggc tctgtctcca gtcccaggaa     1260

ataaagtgtg gaacatctca tcagaaaaga tcacttttct cttaggttct gaaatttcct     1320

caacagaccc tccactgagt gttacagaat ctacccttga cacccaacct tctccagcca     1380

gcagtgtatc tcctgcaaga tatccagcta catcttcagt gacccttgta gatgtgagtg     1440

ccttgaggcc aaacaccact cctcaaccca gcaattccag tatgactacc cgaggcttca     1500

actatccctg gacctccagt gggacagata ccaaaaaatc agtttcacgg atacctagtg     1560

aaacatacag ttcatccccg tcaggtgcag gctcaacact tcatgacaat gtctttacca     1620

gcacagccag agcattttca gaagtcccca caactgccaa tggatctacg aaaactaatc     1680

acgtccatat cactggtatt gtggtcaata agcccaaaga tggaatgtcc tggccagtga     1740

ttgtagcagc tttactcttt tgctgcatga tattgtttgg tcttggagtg agaaaatggt     1800

gtcagtacca aaaagaaata atggaaagac ctccaccttt caagccacca ccacctccca     1860

tcaagtacac ttgcattcaa gagcccaacg aaagtgatct gccttatcat gagatggaga     1920

ccctctagtc tcgtgagact ttgccccatg gcagaactct gctggaatcc tattgagaag     1980

gtagacattg tgctttatta atatagtcgc tcttcagcca tgcctttgct gcagctgaaa     2040

tggaagtcag aagtgagtga cctgttttcc cagcaactca ccctcttcca tctccaaacg     2100

cctgaagctt aaccaagagt gagaggatat gtcatgttca cactcaatgc aattcgtagt     2160

ggttttcttg cttatgtaag aagtacatat tagtctgcca tctttaaaaa aaaatacagt     2220

attttcattt aaattctctg atggagggac aacaatggtt tcaactgtat gcccatgcct     2280

gatcctctta tttgaacatc tatcaacatt gtaaactctt tgccaaaatc ctggggcttt     2340

gctgcattcc ctaagataat tacaggaaaa agaaaatgta aaagtgctaa caaggctgcc     2400

aagtaatgga gaagtatggt tagtcttcat attgaaattc tgttgcttat tttcatggaa     2460

ggaaacagaa tactttgcac aggaaccaca ttttcaatcc tccttcactg tcttcctacc     2520

atgttcagcc cagactcctg ccacatggac caggatgaag agggatcaaa gagataatta     2580

gccaaaaacc cagtagccta gaagatacaa aactccactg gcctctaaaa ttatattagc     2640

caagagtggt ttcatttgag tgccttcgtg tgtatgtcca tcaaactgga accaaactgt     2700

tttgtaagta aacaggcagc ctaagcccaa ccctactttc taattccagt tattctcttt     2760

ttcatctggg gatttacctg ttcatttaat ctgcctgttt tgatctgttt tgaaaaagat     2820

aaagagcctc aaatcagacc agcactgatt aattaaccct gctcctacca atctttttta     2880

aagcagttga agcagaatgt ataggtgtca gagaagaaac ctagtcagcc agacgtgctc     2940

tgtattcagc aatagtttgt gaatgaataa attactaatc ctccttgtcg cttgaaacct     3000

tcccacactc cctgctccag gagggaaaaa cagatgttgt tgacagatag agtgataggc     3060

aaattctgtg tggactttag tcccaaaagg aaactttagt tcacttgcag tatgcttatc     3120

cttgactgca catgagaatg ccttgtgcag agttatttgg agattatgtc tttttcttaa     3180

acaccatggc tgtcacactt cagttcaatt aaatcagaat gtctgaggag tgagacacag     3240

gcatcaacac tctcaaatga ttcacatgtt cagccaaagt tgagaaccat cgagcctgtg     3300

gaagttcttt ctcatggctc agaatcttag gtaggtgctt aactcttgtg gtggccagcc     3360

tccaagatga gccccagtgt tcttgcctcc tactattcac atctttatgt ggtcccctcc     3420

aatgctgaat acagatgatt tgtgtaacct gaggccagga ttaaggggag gcaatcaatg     3480

cacctaggga aaaaatttaa ggaggtattc acactcaggg tcatgcactt gcacaatgtt     3540

gagaatgagt accactctca ccattggtat agccaaaaaa gcttggaagt gaccaaggct     3600

aggtcacaaa atacactgtg gcttcttctt tgatctctct ttgaccatac tgacactggg     3660

aaaagcccat tcccatgcca tgaagacacc aaggcagccc tattgagaaa tctacctgtc     3720

gtggccgggc gcagtggctc acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg     3780

gatcacgagg tcaggagatc gagaccatcc tggctaacac agtgaaaccc cgtctctact     3840

aaaaatacaa aaaattagcc gggtgtggtg tcgggcacct gtagtcccag ctactcagga     3900

ggctgaggca ggagaagggt gggaacccgg gaggcagagc ttgcagtgag ccgagattgt     3960

gccactgcac actccaatct gggtgaaaga ccgagactcc gcctcaaaaa aaaaaaaaaa     4020

agaaagaaag aaagaaagaa agaaatctac ctgtcaagga actaaggtat tttgctaaca     4080

agcaccaact tgccagccat gtaagggagc catcttggaa gcagatcctc cagcctccag     4140

tcaagtcttc agataattgc aacttcagtt gatcttttga ccaagacctc aagagagcca     4200

gaactaccca gctaagcctt ttactaaatt tctgaacttc taacactatt agataataag     4260

tgcttattgt ttaacaccat taattttgag tataatttgt tacatagcga cagataacta     4320

tacagctcaa caactagaaa aataaactgt ttacctgcct taattattta tctttagttc     4380

cttattagtt ctcaagaaac aaatgctagc ttcatatgta tggctgttgc tttgcttcat     4440

gtgtatggct atttgtattt aacaagactt aatcatcagt a                         4481


<210>  352
<211>  585
<212>  PRT
<213>  Homo Sapiens

<400>  352

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
        515                 520                 525             


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
    530                 535                 540                 


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
                565                 570                 575     


Leu Pro Tyr His Glu Met Glu Thr Leu 
            580                 585 


<210>  353
<211>  2026
<212>  DNA
<213>  Homo Sapiens

<400>  353
caatcccccc tcccccccca atctgtcttt ctagcatgtt gccctttttc aaccacattt       60

gtgtttcagg tgtagagagg agagagagtg aacagggagc ggggcttttg tctgttggtc      120

tccctggact gaagagaggg agaatagaag cccaagacta agattctcaa aatggtttat      180

tacccagaac tctttgtctg ggtcagtcaa gaaccatttc caaacaagga catggaggga      240

aggcttccta agggaagact tcctgtccca aaggaagtga accgcaagaa gaacgatgag      300

acaaacgctg cctccctgac tccactgggc agcagtgaac tccgctcccc aagaatcagt      360

tacctccact ttttttaatc gtaacacctc catttgtatt acatatggtg tatgggtatt      420

gatgaggtca tggtatcata tatgggattt ttttctgtgt aaatcatcaa gtataagaag      480

aaactatggg actctgagcc ttgctttaga gaatttacag tggacaaata ggtgtcatca      540

aaccagtttt taatcattct gactcaagtg aaaacgctca gaatttcaca ctgtgaatcc      600

acgtttacaa cccttacagg tgggccttca ggcctggttc gctacaacaa tgtcttccac      660

aactcaaact cccaccgcgc tcacacaacc ggtccactcc tgccttttca ctcacacagc      720

tcccgactgc ttcttgcaga ggctgagagt ccccccccca cctttttttt catttagatg      780

taacaaacct agtagtttat gttcatcaat tgtctgtata tctctatatt ttatccatgt      840

actcttttga tgtatagaag tagtttgaaa ctcattgttt ccttgtggta agtgaccgag      900

atgctgccac aggacctgag acactgatga atggtgctat tttggacttt caacatgctc      960

cttggcgagg tagctctgat ggagttattt tttatttcca tgttctaaga aggtgttggt     1020

actctgtttc cctgaatgtt gttctctaga ctggattgac ttgttttcct tgtgtcttca     1080

gtgtggcttt cttcctcagt gttgtaggtt gagcgaatgc taccagagtg tgagagacca     1140

ttgtctcgtt ggctggcgct cacggacatg cagtcacggt agcgggagca atcacaaaac     1200

tgtaatttac ttaccaaatc tcttcctttc cgtagcctcg cctgcctgac ttagagaaag     1260

aaaagcaata attttacagg cattttgagg tgtctctttg ggttctttct gtttgaaagg     1320

atatttgtcg aaaaaaagag caaaaccgtt ttaaataaac tccccctgga aaaaaaccca     1380

aaacactggc atctgagtgg gaatatgaaa atgacacctt ttccaaatat taaattggaa     1440

aacaaggtct acaaaatcat gatacttttt taaaaggcag agcattcttt tttcggcaat     1500

tttgataagc aaggtgtaga tttacatttt tgtccttgct cccaacgaaa tggataaaca     1560

aaaataaatt accatctact catggaatgt tgttgtgtta gccagtctga aagcccacct     1620

taatttttat ataactgtct ttagctcttc ttttgacagg gcaggccttg ttctgaactg     1680

tttcgcttct gactgttaaa caccgatgac gcatgcactg cacttcttcg ttttcttctt     1740

gctcccccat tggcctgagt ttcttgtgca ttactcctct ccctccttcg ttagaatagg     1800

tatatcagct gtgtaaatag agcaagaaaa cagtattctg catctgtggc atttatgtag     1860

agttgcagtt gtgtactgct gaaaatgcag gcttttgtaa cagtgtgatc tttactgatg     1920

cactcatgac aagtacccaa tgtattttag ctattttagt agtatttgtt caataaatac     1980

gcaagctgta aggtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    2026


<210>  354
<211>  68
<212>  PRT
<213>  Homo Sapiens

<400>  354

Met Val Tyr Tyr Pro Glu Leu Phe Val Trp Val Ser Gln Glu Pro Phe 
1               5                   10                  15      


Pro Asn Lys Asp Met Glu Gly Arg Leu Pro Lys Gly Arg Leu Pro Val 
            20                  25                  30          


Pro Lys Glu Val Asn Arg Lys Lys Asn Asp Glu Thr Asn Ala Ala Ser 
        35                  40                  45              


Leu Thr Pro Leu Gly Ser Ser Glu Leu Arg Ser Pro Arg Ile Ser Tyr 
    50                  55                  60                  


Leu His Phe Phe 
65              


<210>  355
<211>  4894
<212>  DNA
<213>  Homo Sapiens

<400>  355
cgccgcggga ggcggacgag atgcgagcgc ggccgcggcc ccggccgctc tgggcgactg       60

tgctggcgct gggggcgctg gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc      120

gaggtgtgag ctcctgccag cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg      180

atgaggccct gcctctgggc tcacctcgct gtgacctgaa ggagaatctg ctgaaggata      240

actgtgcccc agaatccatc gagttcccag tgagtgaggc ccgagtacta gaggacaggc      300

ccctcagcga caagggctct ggagacagct cccaggtcac tcaagtcagt ccccagagga      360

ttgcactccg gctccggcca gatgattcga agaatttctc catccaagtg cggcaggtgg      420

aggattaccc tgtggacatc tactacttga tggacctgtc ttactccatg aaggatgatc      480

tgtggagcat ccagaacctg ggtaccaagc tggccaccca gatgcgaaag ctcaccagta      540

acctgcggat tggcttcggg gcatttgtgg acaagcctgt gtcaccatac atgtatatct      600

ccccaccaga ggccctcgaa aacccctgct atgatatgaa gaccacctgc ttgcccatgt      660

ttggctacaa acacgtgctg acgctaactg accaggtgac ccgcttcaat gaggaagtga      720

agaagcagag tgtgtcacgg aaccgagatg ccccagaggg tggctttgat gccatcatgc      780

aggctacagt ctgtgatgaa aagattggct ggaggaatga tgcatcccac ttgctggtgt      840

ttaccactga tgccaagact catatagcat tggacggaag gctggcaggc attgtccagc      900

ctaatgacgg gcagtgtcat gttggtagtg acaatcatta ctctgcctcc actaccatgg      960

attatccctc tttggggctg atgactgaga agctatccca gaaaaacatc aatttgatct     1020

ttgcagtgac tgaaaatgta gtcaatctct atcagaacta tagtgagctc atcccaggga     1080

ccacagttgg ggttctgtcc atggattcca gcaatgtcct ccagctcatt gttgatgctt     1140

atgggaaaat ccgttctaaa gtagagctgg aagtgcgtga cctccctgaa gagttgtctc     1200

tatccttcaa tgccacctgc ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg     1260

gactcaagat tggagacacg gtgagcttca gcattgaggc caaggtgcga ggctgtcccc     1320

aggagaagga gaagtccttt accataaagc ccgtgggctt caaggacagc ctgatcgtcc     1380

aggtcacctt tgattgtgac tgtgcctgcc aggcccaagc tgaacctaat agccatcgct     1440

gcaacaatgg caatgggacc tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg     1500

gatcccagtg tgagtgctca gaggaggact atcgcccttc ccagcaggac gaatgcagcc     1560

cccgggaggg tcagcccgtc tgcagccagc ggggcgagtg cctctgtggt caatgtgtct     1620

gccacagcag tgactttggc aagatcacgg gcaagtactg cgagtgtgac gacttctcct     1680

gtgtccgcta caagggggag atgtgctcag gccatggcca gtgcagctgt ggggactgcc     1740

tgtgtgactc cgactggacc ggctactact gcaactgtac cacgcgtact gacacctgca     1800

tgtccagcaa tgggctgctg tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct     1860

gtatccagcc gggctcctat ggggacacct gtgagaagtg ccccacctgc ccagatgcct     1920

gcacctttaa gaaagaatgt gtggagtgta agaagtttga ccggggagcc ctacatgacg     1980

aaaatacctg caaccgttac tgccgtgacg agattgagtc agtgaaagag cttaaggaca     2040

ctggcaagga tgcagtgaat tgtacctata agaatgagga tgactgtgtc gtcagattcc     2100

agtactatga agattctagt ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc     2160

ccaagggccc tgacatcctg gtggtcctgc tctcagtgat gggggccatt ctgctcattg     2220

gccttgccgc cctgctcatc tggaaactcc tcatcaccat ccacgaccga aaagaattcg     2280

ctaaatttga ggaagaacgc gccagagcaa aatgggacac agccaacaac ccactgtata     2340

aagaggccac gtctaccttc accaatatca cgtaccgggg cacttaatga taagcagtca     2400

tcctcagatc attatcagcc tgtgccacga ttgcaggagt ccctgccatc atgtttacag     2460

aggacagtat ttgtggggag ggatttgggg ctcagagtgg ggtaggttgg gagaatgtca     2520

gtatgtggaa gtgtgggtct gtgtgtgtgt atgtgggggt ctgtgtgttt atgtgtgtgt     2580

gttgtgtgtg ggagtgtgta atttaaaatt gtgatgtgtc ctgataagct gagctcctta     2640

gcctttgtcc cagaatgcct cctgcaggga ttcttcctgc ttagcttgag ggtgactatg     2700

gagctgagca ggtgttcttc attacctcag tgagaagcca gctttcctca tcaggccatt     2760

gtccctgaag agaagggcag ggctgaggcc tctcattcca gaggaaggga caccaagcct     2820

tggctctacc ctgagttcat aaatttatgg ttctcaggcc tgactctcag cagctatggt     2880

aggaactgct gggcttggca gcccgggtca tctgtacctc tgcctccttt cccctccctc     2940

aggccgaagg aggagtcagg gagagctgaa ctattagagc tgcctgtgcc ttttgccatc     3000

ccctcaaccc agctatggtt ctctcgcaag ggaagtcctt gcaagctaat tctttgacct     3060

gttgggagtg aggatgtctg ggccactcag gggtcattca tggcctgggg gatgtaccag     3120

catctcccag ttcataatca caacccttca gatttgcctt attggcagct ctactctgga     3180

ggtttgttta gaagaagtgt gtcaccctta ggccagcacc atctctttac ctcctaattc     3240

cacaccctca ctgctgtaga catttgctat gagctgggga tgtctctcat gaccaaatgc     3300

ttttcctcaa agggagagag tgctattgta gagccagagg tctggcccta tgcttccggc     3360

ctcctgtccc tcatccatag cacctccaca tacctggccc tgtgccttgg tgtgctgtat     3420

ccatccatgg ggctgattgt atttaccttc tacctcttgg ctgccttgtg aaggaattat     3480

tcccatgagt tggctgggaa taagtgccag gatggaatga tgggtcagtt gtatcagcac     3540

gtgtggcctg ttcttctatg ggttggacaa cctcatttta actcagtctt taatctgaga     3600

ggccacagtg caattttatt ttatttttct catgatgagg ttttcttaac ttaaaagaac     3660

atgtatataa acatgcttgc attatatttg taaatttatg tgatggcaaa gaaggagagc     3720

ataggaaacc acacagactt gggcagggta cagacactcc cacttggcat cattcacagc     3780

aagtcactgg ccagtggctg gatctgtgag gggctctctc atgatagaag gctatgggga     3840

tagatgtgtg gacacattgg acctttcctg aggaagaggg actgttcttt tgtcccagaa     3900

aagcagtggc tccattggtg ttgacataca tccaacatta aaagccaccc ccaaatgccc     3960

aagaaaaaaa gaaagactta tcaacatttg ttccatgagc agaaaactgg agctctggcc     4020

tcagtgttac agctaaataa tctttaatta aggcaagtca ctttcttctt cttaaagctg     4080

ttttctagtt tgagaaatga tgggatttta gcagccagtc ttgaaggtct ctttcagtat     4140

caacattcta agatgctggg acttactgtg tcatcaaatg tgcggttaag attctctggg     4200

atattgatac tgtttgtgtt tttagttggg agatctgaga gacctggctt tggcaagagc     4260

agatgtcatt ccatatcacc tttctcaatg aaagtctcat tctatcctct ctccaaaccc     4320

gttttccaac atttgttaat agttacgtct ctcctgatgt agcacttaag cttcatttag     4380

ttattatttc tttcttcact ttgcacacat ttgcatccac atattaggga agaggaatcc     4440

ataagtagct gaaatatcta ttctgtatta ttgtgttaac attgagaata agccttggaa     4500

ttagatatgg ggcaatgact gagccctgtc tcacccatgg attactcctt actgtaggga     4560

atggcagtat ggtagaggga taaatagggg gcggggaggg atagtcatgg atccaagaag     4620

tccttagaaa tagtggcagg gaacaggtgt ggaagctcat gcctgtaatt ataaccttca     4680

gctactaaga caggtgtggt ggctcacgcc tgtgattata atcttcagtt actaagacag     4740

agtccatgag agtgttaatg ggacattttc tttagataag atgttttata tgaagaaact     4800

gtatcaaagg gggaagaaaa tgtatttaac aggtgaatca aatcaggaat cttgtctgag     4860

ctactggaat gaagttcaca ggtcttgaag acca                                 4894


<210>  356
<211>  788
<212>  PRT
<213>  Homo Sapiens

<400>  356

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  357
<211>  7346
<212>  DNA
<213>  Homo Sapiens

<400>  357
gcgaggagga aacggtgccg gagcgcgcag ggcttgctgc cgccaccgcc gctgcacagg       60

ctgccggagc gagcctgccg cgcgccgccc tccccgctct ccttcctggg cgagctgcgg      120

ggatggggcg gccgcgggag cccgagcgcg cgcaggaacc gccgccgccg ccgcccgcgt      180

ctccgttgcc gcgcgcctga gccgccgtcg ccgccgcgcg ccctgcccgg gggcggcccc      240

cccagcccca tggaggtctc ccggaggaag gcgccgccgc gccccccgcg ccccgcagcg      300

ccactgcccc tgctcgccta tctgctggca ctggcggctc ccggccgggg cgcggacgag      360

cccgtgtggc ggtcggagca agccatcgga gccatcgcgg cgagccagga ggacggcgtg      420

tttgtggcga gcggcagctg cctggaccag ctggactaca gcctggagca cagcctctcg      480

cgcctgtacc gggaccaagc gggcaactgc acagagccgg tctcgctggc gccccccgcg      540

cggccccggc ccgggagcag cttcagcaag ctgctgctgc cctaccgcga gggggcggcc      600

ggcctcgggg ggctgctgct caccggctgg accttcgacc ggggcgcctg cgaggtgcgg      660

cccctgggca acctgagccg caactccctg cgcaacggca ccgaggtggt gtcgtgccac      720

ccgcagggct cgacggccgg cgtggtgtac cgcgcgggcc ggaacaaccg ctggtacctg      780

gcggtggccg ccacctacgt gctgcctgag ccggagacgg cgagccgctg caaccccgcg      840

gcatccgacc acgacacggc catcgcgctc aaggacacgg aggggcgcag cctggccacg      900

caggagctgg ggcgcctcaa gctgtgcgag ggcgcgggca gcctgcactt cgtggacgcc      960

tttctctgga acggcagcat ctacttcccc tactacccct acaactacac gagcggcgct     1020

gccaccggct ggcccagcat ggcgcgcatc gcgcagagca ccgaggtgct gttccagggc     1080

caggcatccc tcgactgcgg ccacggccac cccgacggcc gccgcctgct cctctcctcc     1140

agcctagtgg aggccctgga cgtctgggcg ggagtgttca gcgcggccgc tggagagggc     1200

caggagcggc gctcccccac caccacggcg ctctgcctct tcagaatgag tgagatccag     1260

gcgcgcgcca agagggtcag ctgggacttc aagacggccg agagccactg caaagaaggg     1320

gatcaacctg aaagagtcca accaatcgca tcatctacct tgatccattc cgacctgaca     1380

tccgtttatg gcaccgtggt aatgaacagg actgttttat tcttggggac tggagatggc     1440

cagttactta aggttattct tggtgagaat ttgacttcaa attgtccaga ggttatctat     1500

gaaattaaag aagagacacc tgttttctac aaactcgttc ctgatcctgt gaagaatatc     1560

tacatttatc taacagctgg gaaagaggtg aggagaattc gtgttgcaaa ctgcaataaa     1620

cataaatcct gttcggagtg tttaacagcc acagaccctc actgcggttg gtgccattcg     1680

ctacaaaggt gcacttttca aggagattgt gtacattcag agaacttaga aaactggctg     1740

gatatttcgt ctggagcaaa aaagtgccct aaaattcaga taattcgaag cagtaaagaa     1800

aagactacag tgactatggt gggaagcttc tctccaagac actcaaagtg catggtgaag     1860

aatgtggact ctagcaggga gctctgccag aataaaagtc agcccaaccg gacctgcacc     1920

tgtagcatcc caaccagagc aacctacaaa gatgtttcag ttgtcaacgt gatgttctcc     1980

ttcggttctt ggaatttatc agacagattc aactttacca actgctcatc attaaaagaa     2040

tgcccagcat gcgtagaaac tggctgcgcg tggtgtaaaa gtgcaagaag gtgtatccac     2100

cccttcacag cttgcgaccc ttctgattat gagagaaacc aggaacagtg tccagtggct     2160

gtcgagaaga catcaggagg aggaagaccc aaggagaaca aggggaacag aaccaaccag     2220

gctttacagg tcttctacat taagtccatt gagccacaga aagtatcgac attagggaaa     2280

agcaacgtga tagtaacggg agcaaacttt acccgggcat cgaacatcac aatgatcctg     2340

aaaggaacca gtacctgtga taaggatgtg atacaggtta gccatgtgct aaatgacacc     2400

cacatgaaat tctctcttcc atcaagccgg aaagaaatga aggatgtgtg tatccagttt     2460

gatggtggga actgctcttc tgtgggatcc ttatcctaca ttgctctgcc acattgttcc     2520

cttatatttc ctgctaccac ctggatcagt ggtggtcaaa atataaccat gatgggcaga     2580

aattttgatg taattgacaa cttaatcatt tcacatgaat taaaaggaaa cataaatgtc     2640

tctgaatatt gtgtggcgac ttactgcggg tttttagccc ccagtttaaa gagttcaaaa     2700

gtgcgcacga atgtcactgt gaagctgaga gtacaagaca cctacttgga ttgtggaacc     2760

ctgcagtatc gggaggaccc cagattcacg gggtatcggg tggaatccga ggtggacaca     2820

gaactggaag tgaaaattca aaaagaaaat gacaacttca acatttccaa aaaagacatt     2880

gaaattactc tcttccatgg ggaaaatggg caattaaatt gcagttttga aaatattact     2940

agaaatcaag atcttaccac catcctttgc aaaattaaag gcatcaagac tgcaagcacc     3000

attgccaact cttctaagaa agttcgggtc aagctgggaa acctggagct ctacgtcgag     3060

caggagtcag ttccttccac atggtatttt ctgattgtgc tccctgtctt gctagtgatt     3120

gtcatttttg cggccgtggg ggtgaccagg cacaaatcga aggagctgag tcgcaaacag     3180

agtcaacaac tagaattgct ggaaagcgag ctccggaaag agatacgtga cggctttgct     3240

gagctgcaga tggataaatt ggatgtggtt gatagttttg gaactgttcc cttccttgac     3300

tacaaacatt ttgctctgag aactttcttc cctgagtcag gtggcttcac ccacatcttc     3360

actgaagata tgcataacag agacgccaac gacaagaatg aaagtctcac agctttggat     3420

gccctaatct gtaataaaag ctttcttgtt actgtcatcc acacccttga aaagcagaag     3480

aacttttctg tgaaggacag gtgtctgttt gcctccttcc taaccattgc actgcaaacc     3540

aagctggtct acctgaccag catcctagag gtgctgacca gggacttgat ggaacagtgt     3600

agtaacatgc agccgaaact catgctgaga cgcacggagt ccgtcgtcga aaaactcctc     3660

acaaactgga tgtccgtctg cctttctgga tttctccggg agactgtcgg agagcccttc     3720

tatttgctgg tgacgactct gaaccagaaa attaacaagg gtcccgtgga tgtaatcact     3780

tgcaaagccc tgtacacact taatgaagac tggctgttgt ggcaggttcc ggaattcagt     3840

actgtggcat taaacgtcgt ctttgaaaaa atcccggaaa acgagagtgc agatgtctgt     3900

cggaatattt cagtcaatgt tctcgactgt gacaccattg gccaagccaa agaaaagatt     3960

ttccaagcat tcttaagcaa aaatggctct ccttatggac ttcagcttaa tgaaattggt     4020

cttgagcttc aaatgggcac acgacagaaa gaacttctgg acatcgacag ttcctccgtg     4080

attcttgaag atggaatcac caagctaaac accattggcc actatgagat atcaaatgga     4140

tccactataa aagtctttaa gaagatagca aattttactt cagatgtgga gtactcggat     4200

gaccactgcc atttgatttt accagattcg gaagcattcc aagatgtgca aggaaagaga     4260

catcgaggga agcacaagtt caaagtaaaa gaaatgtatc tgacaaagct gctgtcgacc     4320

aaggtggcaa ttcattctgt gcttgaaaaa ctttttagaa gcatttggag tttacccaac     4380

agcagagctc catttgctat aaaatacttt tttgactttt tggacgccca ggctgaaaac     4440

aaaaaaatca cagatcctga cgtcgtacat atttggaaaa caaacagcct tcctcttcgc     4500

ttctgggtaa acatcctgaa gaaccctcag tttgtctttg acattaagaa gacaccacat     4560

atagacggct gtttgtcagt gattgcccag gcattcatgg atgcattttc tctcacagag     4620

cagcaactag ggaaggaagc accaactaat aagcttctct atgccaagga tatcccaacc     4680

tacaaagaag aagtaaaatc ttattacaaa gcaatcaggg atttgcctcc attgtcatcc     4740

tcagaaatgg aagaattttt aactcaggaa tctaagaaac atgaaaatga atttaatgaa     4800

gaagtggcct tgacagaaat ttacaaatac atcgtaaaat attttgatga gattctaaat     4860

aaactagaaa gagaacgagg gctggaagaa gctcagaaac aactcttgca tgtaaaagtc     4920

ttatttgatg aaaagaagaa atgcaagtgg atgtaagcac tctggggcct ggcttaatct     4980

ggcaaagttc ttcagacgac ttgggagcaa aatggctgct tgagctactc tgtgtcgtta     5040

atttgttgtt tgcacatagg ttccactttg ggcactgtct ttttaagaga ccaaggcaca     5100

tgcacagctt ttagaaagca taccaaccct tgtgcctgtg tgtataccgt gggaaccctt     5160

ctgtaaatag agttgaagtg gttgttgcaa acagcctcct tgtttacaga gaatacaagg     5220

ccagtaagcg aatgtcagta ttgtaactac agtctccact taagcacaat gatataagtg     5280

gttttgtttg aaaactacag ctatgtagca cttgtgctac actgcacctc tgcattgtaa     5340

agggatactg ccagtgctca aaacaaaatg tgaaatgagt catttggaaa caaggtgggg     5400

gtgttagggc aacctcgagg atttgcagca ttgaaacttt ccccagtagt tcttggaaaa     5460

gctgaccgca gaatttggta gtgtacactt agcatttgtg agtgtgtgtg tgtgtttaaa     5520

ccaaaaacta acagtgttgc aacattgttg aaagggctcg tgtttttcag tggtcatcaa     5580

ctgcactcca tcaaactcac ctccatttca ccaaggagct ctaaagtaag gagagtgggc     5640

tttatttaaa tgaacagcat tttaaccaga tactttgtcc taatgtatgt tccttttctt     5700

catctgtttt ttcatactaa atgtatttga tagtggacat gttggatatt atacaaaaaa     5760

atcattaatt catttctgtt ccaaaacctt tgatcagaac gatctgtgga agagtaactc     5820

catttctata tgagtgagtg tctccttgct ttagatttct ggtgaaccct gtggttatga     5880

atacttgtgt gtgatttaaa aaaaaaaaga tacattttac atttcatcga attgctgttc     5940

acactggagt attatatata aatatatata tttgaggccc aaggcctgaa aaatattagt     6000

atacaacttg gtatcttagt cttactatgt actttttgaa agtattcctc gcaggagaaa     6060

gaatttaaaa tacccatttt attcatgcct ttctttttaa agaattctct atccagttat     6120

actgtagtct ttttagtgct gattttttaa ttcctgaatt tttgctgctc atgaccagtt     6180

ttaataccac tgtgttttcc ttctattaaa ccagaagaag taaacagcat aattggcaac     6240

tcttgagctt ttcttgtggc aggcaccttt tacccttggt gctccaaatc ccccatctag     6300

gaaagaaaat tttttcaagt caaataacat tgatcacata ttccttgaaa tcatttacca     6360

acactgtatg gagcattagg atttaaatat gaatttgtct taaaggcaat tcctttttgc     6420

ttctgtatta tctggaaaag catgagagag gtgacacctc aacaaactga tcagagaaaa     6480

taagcagtta ctaccctgat aggcaccttc ccaatcctgt tgcttttgac cattgtctgt     6540

ccaacggaca cacctcaaac aaacaaaact accaaataga tgacagatca gaataaaggt     6600

gagaggtctg gtccccattg aaggctgcta cagtcttcaa agaggtgaag gagttcataa     6660

gagaacaaca gtaggaaagt tgagagccaa gggtaggaga gttgcccaaa agacttcccc     6720

tactacttta gggtactgaa aactcaaagg atcagctaca gctttatcta agtatttact     6780

aaatgctaca tgagggtgtc cctgtccagc tttctggcac atgagtcctg tgtggagagt     6840

tacctcctct tccagggact gtgctgttgg gaactttggg caagtcactt acctctttgt     6900

gcctcaattt ctgtataata tttctaagct acctcactga ggtggtatga agattcacta     6960

atgtatgtag cgtgtttgtc aatcctccag tgaaaagcac tatctagatc acattttgga     7020

tcacattagc caaatgcagt aaatggccaa attagatgtg tgctgaagac aatcagtcac     7080

tgggtctata ttaaacagca accagagcaa caaatggcaa acaatttcta ttttcaagtt     7140

tctttgcata tttttttggt gcaaaaccat ttataaactt ttttttctaa cactagtgtc     7200

tacagcagca ttcaaaaaaa ttctgttacc ttttctgtat taggatttaa agtctatttc     7260

ttattgtata cctgattgaa gctgttcttg gagatgaatg ttttaaatgt ctatatccaa     7320

aaaataaaca ttttgatgta actgtg                                          7346


<210>  358
<211>  1568
<212>  PRT
<213>  Homo Sapiens

<400>  358

Met Glu Val Ser Arg Arg Lys Ala Pro Pro Arg Pro Pro Arg Pro Ala 
1               5                   10                  15      


Ala Pro Leu Pro Leu Leu Ala Tyr Leu Leu Ala Leu Ala Ala Pro Gly 
            20                  25                  30          


Arg Gly Ala Asp Glu Pro Val Trp Arg Ser Glu Gln Ala Ile Gly Ala 
        35                  40                  45              


Ile Ala Ala Ser Gln Glu Asp Gly Val Phe Val Ala Ser Gly Ser Cys 
    50                  55                  60                  


Leu Asp Gln Leu Asp Tyr Ser Leu Glu His Ser Leu Ser Arg Leu Tyr 
65                  70                  75                  80  


Arg Asp Gln Ala Gly Asn Cys Thr Glu Pro Val Ser Leu Ala Pro Pro 
                85                  90                  95      


Ala Arg Pro Arg Pro Gly Ser Ser Phe Ser Lys Leu Leu Leu Pro Tyr 
            100                 105                 110         


Arg Glu Gly Ala Ala Gly Leu Gly Gly Leu Leu Leu Thr Gly Trp Thr 
        115                 120                 125             


Phe Asp Arg Gly Ala Cys Glu Val Arg Pro Leu Gly Asn Leu Ser Arg 
    130                 135                 140                 


Asn Ser Leu Arg Asn Gly Thr Glu Val Val Ser Cys His Pro Gln Gly 
145                 150                 155                 160 


Ser Thr Ala Gly Val Val Tyr Arg Ala Gly Arg Asn Asn Arg Trp Tyr 
                165                 170                 175     


Leu Ala Val Ala Ala Thr Tyr Val Leu Pro Glu Pro Glu Thr Ala Ser 
            180                 185                 190         


Arg Cys Asn Pro Ala Ala Ser Asp His Asp Thr Ala Ile Ala Leu Lys 
        195                 200                 205             


Asp Thr Glu Gly Arg Ser Leu Ala Thr Gln Glu Leu Gly Arg Leu Lys 
    210                 215                 220                 


Leu Cys Glu Gly Ala Gly Ser Leu His Phe Val Asp Ala Phe Leu Trp 
225                 230                 235                 240 


Asn Gly Ser Ile Tyr Phe Pro Tyr Tyr Pro Tyr Asn Tyr Thr Ser Gly 
                245                 250                 255     


Ala Ala Thr Gly Trp Pro Ser Met Ala Arg Ile Ala Gln Ser Thr Glu 
            260                 265                 270         


Val Leu Phe Gln Gly Gln Ala Ser Leu Asp Cys Gly His Gly His Pro 
        275                 280                 285             


Asp Gly Arg Arg Leu Leu Leu Ser Ser Ser Leu Val Glu Ala Leu Asp 
    290                 295                 300                 


Val Trp Ala Gly Val Phe Ser Ala Ala Ala Gly Glu Gly Gln Glu Arg 
305                 310                 315                 320 


Arg Ser Pro Thr Thr Thr Ala Leu Cys Leu Phe Arg Met Ser Glu Ile 
                325                 330                 335     


Gln Ala Arg Ala Lys Arg Val Ser Trp Asp Phe Lys Thr Ala Glu Ser 
            340                 345                 350         


His Cys Lys Glu Gly Asp Gln Pro Glu Arg Val Gln Pro Ile Ala Ser 
        355                 360                 365             


Ser Thr Leu Ile His Ser Asp Leu Thr Ser Val Tyr Gly Thr Val Val 
    370                 375                 380                 


Met Asn Arg Thr Val Leu Phe Leu Gly Thr Gly Asp Gly Gln Leu Leu 
385                 390                 395                 400 


Lys Val Ile Leu Gly Glu Asn Leu Thr Ser Asn Cys Pro Glu Val Ile 
                405                 410                 415     


Tyr Glu Ile Lys Glu Glu Thr Pro Val Phe Tyr Lys Leu Val Pro Asp 
            420                 425                 430         


Pro Val Lys Asn Ile Tyr Ile Tyr Leu Thr Ala Gly Lys Glu Val Arg 
        435                 440                 445             


Arg Ile Arg Val Ala Asn Cys Asn Lys His Lys Ser Cys Ser Glu Cys 
    450                 455                 460                 


Leu Thr Ala Thr Asp Pro His Cys Gly Trp Cys His Ser Leu Gln Arg 
465                 470                 475                 480 


Cys Thr Phe Gln Gly Asp Cys Val His Ser Glu Asn Leu Glu Asn Trp 
                485                 490                 495     


Leu Asp Ile Ser Ser Gly Ala Lys Lys Cys Pro Lys Ile Gln Ile Ile 
            500                 505                 510         


Arg Ser Ser Lys Glu Lys Thr Thr Val Thr Met Val Gly Ser Phe Ser 
        515                 520                 525             


Pro Arg His Ser Lys Cys Met Val Lys Asn Val Asp Ser Ser Arg Glu 
    530                 535                 540                 


Leu Cys Gln Asn Lys Ser Gln Pro Asn Arg Thr Cys Thr Cys Ser Ile 
545                 550                 555                 560 


Pro Thr Arg Ala Thr Tyr Lys Asp Val Ser Val Val Asn Val Met Phe 
                565                 570                 575     


Ser Phe Gly Ser Trp Asn Leu Ser Asp Arg Phe Asn Phe Thr Asn Cys 
            580                 585                 590         


Ser Ser Leu Lys Glu Cys Pro Ala Cys Val Glu Thr Gly Cys Ala Trp 
        595                 600                 605             


Cys Lys Ser Ala Arg Arg Cys Ile His Pro Phe Thr Ala Cys Asp Pro 
    610                 615                 620                 


Ser Asp Tyr Glu Arg Asn Gln Glu Gln Cys Pro Val Ala Val Glu Lys 
625                 630                 635                 640 


Thr Ser Gly Gly Gly Arg Pro Lys Glu Asn Lys Gly Asn Arg Thr Asn 
                645                 650                 655     


Gln Ala Leu Gln Val Phe Tyr Ile Lys Ser Ile Glu Pro Gln Lys Val 
            660                 665                 670         


Ser Thr Leu Gly Lys Ser Asn Val Ile Val Thr Gly Ala Asn Phe Thr 
        675                 680                 685             


Arg Ala Ser Asn Ile Thr Met Ile Leu Lys Gly Thr Ser Thr Cys Asp 
    690                 695                 700                 


Lys Asp Val Ile Gln Val Ser His Val Leu Asn Asp Thr His Met Lys 
705                 710                 715                 720 


Phe Ser Leu Pro Ser Ser Arg Lys Glu Met Lys Asp Val Cys Ile Gln 
                725                 730                 735     


Phe Asp Gly Gly Asn Cys Ser Ser Val Gly Ser Leu Ser Tyr Ile Ala 
            740                 745                 750         


Leu Pro His Cys Ser Leu Ile Phe Pro Ala Thr Thr Trp Ile Ser Gly 
        755                 760                 765             


Gly Gln Asn Ile Thr Met Met Gly Arg Asn Phe Asp Val Ile Asp Asn 
    770                 775                 780                 


Leu Ile Ile Ser His Glu Leu Lys Gly Asn Ile Asn Val Ser Glu Tyr 
785                 790                 795                 800 


Cys Val Ala Thr Tyr Cys Gly Phe Leu Ala Pro Ser Leu Lys Ser Ser 
                805                 810                 815     


Lys Val Arg Thr Asn Val Thr Val Lys Leu Arg Val Gln Asp Thr Tyr 
            820                 825                 830         


Leu Asp Cys Gly Thr Leu Gln Tyr Arg Glu Asp Pro Arg Phe Thr Gly 
        835                 840                 845             


Tyr Arg Val Glu Ser Glu Val Asp Thr Glu Leu Glu Val Lys Ile Gln 
    850                 855                 860                 


Lys Glu Asn Asp Asn Phe Asn Ile Ser Lys Lys Asp Ile Glu Ile Thr 
865                 870                 875                 880 


Leu Phe His Gly Glu Asn Gly Gln Leu Asn Cys Ser Phe Glu Asn Ile 
                885                 890                 895     


Thr Arg Asn Gln Asp Leu Thr Thr Ile Leu Cys Lys Ile Lys Gly Ile 
            900                 905                 910         


Lys Thr Ala Ser Thr Ile Ala Asn Ser Ser Lys Lys Val Arg Val Lys 
        915                 920                 925             


Leu Gly Asn Leu Glu Leu Tyr Val Glu Gln Glu Ser Val Pro Ser Thr 
    930                 935                 940                 


Trp Tyr Phe Leu Ile Val Leu Pro Val Leu Leu Val Ile Val Ile Phe 
945                 950                 955                 960 


Ala Ala Val Gly Val Thr Arg His Lys Ser Lys Glu Leu Ser Arg Lys 
                965                 970                 975     


Gln Ser Gln Gln Leu Glu Leu Leu Glu Ser Glu Leu Arg Lys Glu Ile 
            980                 985                 990         


Arg Asp Gly Phe Ala Glu Leu Gln  Met Asp Lys Leu Asp  Val Val Asp 
        995                 1000                 1005             


Ser Phe  Gly Thr Val Pro Phe  Leu Asp Tyr Lys His  Phe Ala Leu 
    1010                 1015                 1020             


Arg Thr  Phe Phe Pro Glu Ser  Gly Gly Phe Thr His  Ile Phe Thr 
    1025                 1030                 1035             


Glu Asp  Met His Asn Arg Asp  Ala Asn Asp Lys Asn  Glu Ser Leu 
    1040                 1045                 1050             


Thr Ala  Leu Asp Ala Leu Ile  Cys Asn Lys Ser Phe  Leu Val Thr 
    1055                 1060                 1065             


Val Ile  His Thr Leu Glu Lys  Gln Lys Asn Phe Ser  Val Lys Asp 
    1070                 1075                 1080             


Arg Cys  Leu Phe Ala Ser Phe  Leu Thr Ile Ala Leu  Gln Thr Lys 
    1085                 1090                 1095             


Leu Val  Tyr Leu Thr Ser Ile  Leu Glu Val Leu Thr  Arg Asp Leu 
    1100                 1105                 1110             


Met Glu  Gln Cys Ser Asn Met  Gln Pro Lys Leu Met  Leu Arg Arg 
    1115                 1120                 1125             


Thr Glu  Ser Val Val Glu Lys  Leu Leu Thr Asn Trp  Met Ser Val 
    1130                 1135                 1140             


Cys Leu  Ser Gly Phe Leu Arg  Glu Thr Val Gly Glu  Pro Phe Tyr 
    1145                 1150                 1155             


Leu Leu  Val Thr Thr Leu Asn  Gln Lys Ile Asn Lys  Gly Pro Val 
    1160                 1165                 1170             


Asp Val  Ile Thr Cys Lys Ala  Leu Tyr Thr Leu Asn  Glu Asp Trp 
    1175                 1180                 1185             


Leu Leu  Trp Gln Val Pro Glu  Phe Ser Thr Val Ala  Leu Asn Val 
    1190                 1195                 1200             


Val Phe  Glu Lys Ile Pro Glu  Asn Glu Ser Ala Asp  Val Cys Arg 
    1205                 1210                 1215             


Asn Ile  Ser Val Asn Val Leu  Asp Cys Asp Thr Ile  Gly Gln Ala 
    1220                 1225                 1230             


Lys Glu  Lys Ile Phe Gln Ala  Phe Leu Ser Lys Asn  Gly Ser Pro 
    1235                 1240                 1245             


Tyr Gly  Leu Gln Leu Asn Glu  Ile Gly Leu Glu Leu  Gln Met Gly 
    1250                 1255                 1260             


Thr Arg  Gln Lys Glu Leu Leu  Asp Ile Asp Ser Ser  Ser Val Ile 
    1265                 1270                 1275             


Leu Glu  Asp Gly Ile Thr Lys  Leu Asn Thr Ile Gly  His Tyr Glu 
    1280                 1285                 1290             


Ile Ser  Asn Gly Ser Thr Ile  Lys Val Phe Lys Lys  Ile Ala Asn 
    1295                 1300                 1305             


Phe Thr  Ser Asp Val Glu Tyr  Ser Asp Asp His Cys  His Leu Ile 
    1310                 1315                 1320             


Leu Pro  Asp Ser Glu Ala Phe  Gln Asp Val Gln Gly  Lys Arg His 
    1325                 1330                 1335             


Arg Gly  Lys His Lys Phe Lys  Val Lys Glu Met Tyr  Leu Thr Lys 
    1340                 1345                 1350             


Leu Leu  Ser Thr Lys Val Ala  Ile His Ser Val Leu  Glu Lys Leu 
    1355                 1360                 1365             


Phe Arg  Ser Ile Trp Ser Leu  Pro Asn Ser Arg Ala  Pro Phe Ala 
    1370                 1375                 1380             


Ile Lys  Tyr Phe Phe Asp Phe  Leu Asp Ala Gln Ala  Glu Asn Lys 
    1385                 1390                 1395             


Lys Ile  Thr Asp Pro Asp Val  Val His Ile Trp Lys  Thr Asn Ser 
    1400                 1405                 1410             


Leu Pro  Leu Arg Phe Trp Val  Asn Ile Leu Lys Asn  Pro Gln Phe 
    1415                 1420                 1425             


Val Phe  Asp Ile Lys Lys Thr  Pro His Ile Asp Gly  Cys Leu Ser 
    1430                 1435                 1440             


Val Ile  Ala Gln Ala Phe Met  Asp Ala Phe Ser Leu  Thr Glu Gln 
    1445                 1450                 1455             


Gln Leu  Gly Lys Glu Ala Pro  Thr Asn Lys Leu Leu  Tyr Ala Lys 
    1460                 1465                 1470             


Asp Ile  Pro Thr Tyr Lys Glu  Glu Val Lys Ser Tyr  Tyr Lys Ala 
    1475                 1480                 1485             


Ile Arg  Asp Leu Pro Pro Leu  Ser Ser Ser Glu Met  Glu Glu Phe 
    1490                 1495                 1500             


Leu Thr  Gln Glu Ser Lys Lys  His Glu Asn Glu Phe  Asn Glu Glu 
    1505                 1510                 1515             


Val Ala  Leu Thr Glu Ile Tyr  Lys Tyr Ile Val Lys  Tyr Phe Asp 
    1520                 1525                 1530             


Glu Ile  Leu Asn Lys Leu Glu  Arg Glu Arg Gly Leu  Glu Glu Ala 
    1535                 1540                 1545             


Gln Lys  Gln Leu Leu His Val  Lys Val Leu Phe Asp  Glu Lys Lys 
    1550                 1555                 1560             


Lys Cys  Lys Trp Met 
    1565             


<210>  359
<211>  8482
<212>  DNA
<213>  Homo Sapiens

<400>  359
gcgcgcagtg agaggcgccg gggctgccgc ccggtgctcg gcgcgctctc gggagccgcc       60

cgcccgctgg tcccgcagcc ttccgggagg aagcggtgcc ggcagcgtcc agggcgcgct      120

ctcgggcacc ctcacctgcc ggcgcccggc cgcttacccg gcagggcgtg cgcagggtag      180

ggtgcgggac cggggggacc tggaggcaga ggggagaacc ggccgtccgc gccgcagcac      240

agccgctggg agcgcctcag accccgcgcg gggcgccggc tccatggcga ccgggctcgg      300

ggagccggtc tatggacttt ccgaagacga gggagagtcc cgtattctca gagtaaaagt      360

tgtttctgga attgatctcg ccaaaaagga catctttgga gccagtgatc cgtatgtgaa      420

actttcattg tacgtagcgg atgagaatag agaacttgct ttggtccaga caaaaacaat      480

taaaaagaca ctgaacccaa aatggaatga agaattttat ttcagggtaa acccatctaa      540

tcacagactc ctatttgaag tatttgacga aaatagactg acacgagacg acttcctggg      600

ccaggtggac gtgcccctta gtcaccttcc gacagaagat ccaaccatgg agcgacccta      660

tacatttaag gactttctcc tcagaccaag aagtcataag tctcgagtta agggattttt      720

gcgattgaaa atggcctata tgccaaaaaa tggaggtcaa gatgaagaaa acagtgacca      780

gagggatgac atggagcatg gatgggaagt tgttgactca aatgactcgg cttctcagca      840

ccaagaggaa cttcctcctc ctcctctgcc tcccgggtgg gaagaaaaag tggacaattt      900

aggccgaact tactatgtca accacaacaa ccggaccact cagtggcaca gaccaagcct      960

gatggacgtg tcctcggagt cggacaataa catcagacag atcaaccagg aggcagcaca     1020

ccggcgcttc cgctcccgca ggcacatcag cgaagacttg gagcccgagc cctcggaggg     1080

cggggatgtc cccgagcctt gggagaccat ttcagaggaa gtgaatatcg ctggagactc     1140

tctcggtctg gctctgcccc caccaccggc ctccccagga tctcggacca gccctcagga     1200

gctgtcagag gaactaagca gaaggcttca gatcactcca gactccaatg gggaacagtt     1260

cagctctttg attcaaagag aaccctcctc aaggttgagg tcatgcagtg tcaccgacgc     1320

agttgcagaa cagggccatc taccaccgcc cagtgcccca gctgggagag cgcgttcatc     1380

aactgtcacg ggtggtgagg aaccaacgcc atcagtggcc tatgtacata ccacgccggg     1440

tctgccttca ggctgggaag aaagaaaaga tgctaagggg cgcacatact atgtcaatca     1500

taacaatcga accacaactt ggactcgacc tatcatgcag cttgcagaag atggtgcgtc     1560

cggatcagcc acaaacagta acaaccatct aatcgagcct cagatccgcc ggcctcgtag     1620

cctcagctcg ccaacagtaa ctttatctgc cccgctggag ggtgccaagg actcacccgt     1680

acgtcgggct gtgaaagaca ccctttccaa cccacagtcc ccacagccat caccttacaa     1740

ctcccccaaa ccacaacaca aagtcacaca gagcttcttg ccacccggct gggaaatgag     1800

gatagcgcca aacggccggc ccttcttcat tgatcataac acaaagacta caacctggga     1860

agatccacgt ttgaaatttc cagtacatat gcggtcaaag acatctttaa accccaatga     1920

ccttggcccc cttcctcctg gctgggaaga aagaattcac ttggatggcc gaacgtttta     1980

tattgatcat aatagcaaaa ttactcagtg ggaagaccca agactgcaga acccagctat     2040

tactggtccg gctgtccctt actccagaga atttaagcag aaatatgact acttcaggaa     2100

gaaattaaag aaacctgctg atatccccaa taggtttgaa atgaaacttc acagaaataa     2160

catatttgaa gagtcctatc ggagaattat gtccgtgaaa agaccagatg tcctaaaagc     2220

tagactgtgg attgagtttg aatcagagaa aggtcttgac tatgggggtg tggccagaga     2280

atggttcttc ttactgtcca aagagatgtt caacccctac tacggcctct ttgagtactc     2340

tgccacggac aactacaccc ttcagatcaa ccctaattca ggcctctgta atgaggatca     2400

tttgtcctac ttcactttta ttggaagagt tgctggtctg gccgtatttc atgggaagct     2460

cttagatggt ttcttcatta gaccatttta caagatgatg ttgggaaagc agataaccct     2520

gaatgacatg gaatctgtgg atagtgaata ttacaactct ttgaaatgga tcctggagaa     2580

tgaccctact gagctggacc tcatgttctg catagacgaa gaaaactttg gacagacata     2640

tcaagtggat ttgaagccca atgggtcaga aataatggtc acaaatgaaa acaaaaggga     2700

atatatcgac ttagtcatcc agtggagatt tgtgaacagg gtccagaagc agatgaacgc     2760

cttcttggag ggattcacag aactacttcc tattgatttg attaaaattt ttgatgaaaa     2820

tgagctggag ttgctcatgt gcggcctcgg tgatgtggat gtgaatgact ggagacagca     2880

ttctatttac aagaacggct actgcccaaa ccaccccgtc attcagtggt tctggaaggc     2940

tgtgctactc atggacgccg aaaagcgtat ccggttactg cagtttgtca cagggacatc     3000

gcgagtacct atgaatggat ttgccgaact ttatggttcc aatggtcctc agctgtttac     3060

aatagagcaa tggggcagtc ctgagaaact gcccagagct cacacatgct ttaatcgcct     3120

tgacttacct ccatatgaaa cctttgaaga tttacgagag aaacttctca tggccgtgga     3180

aaatgctcaa ggatttgaag gggtggatta agcaccctgt gcctcggggg tggttgttct     3240

tcaagcaagt tctgcttgca cttttgcatt tgcctaacag acttttgcag aggcgatggc     3300

agagagcagc tgcaggcatg gtccctggag ccgagccttc accacgcact cgtccaagtt     3360

cggatgcggg aacctggtcc cagcttgagt tcctgccttt cccaccacaa attatcaact     3420

ggttgatgtg tacactaatt acatttcagg aggacttaat gctatttatg ttgtgcctct     3480

gcaggcaaag cccttaataa atattttaca tcctttctaa tgacaatgaa tggaattaat     3540

cactcaacag gtatagtatt acgactcatg tttacttttt aaaatgattt agaccgattt     3600

tcagatttta tttcgttatg attaaagatg tctcatgtac ttggaaaagt gagcattttt     3660

tttttttttg tatttcactt tcataccagg cttaatgtca atgacatttt tatttttgaa     3720

gtactctgac acctccaccc tctactttat tagaattgga aggcaaattt ttgtccaaaa     3780

acctacagac aagtactttg agagaatttc caatataata ttagacataa tgataatttt     3840

ttccatactc agaatgaaaa actggatatt acgtttttgt tttggggttt ttttgtacaa     3900

atttagctaa tagctacagg ctgagagaat tgtaacatag catgacaaat tttgtgttga     3960

cttgaaagga atcacaccat tattccttag aagtaattac atgtgttcta acacatttga     4020

gacagggttg gactcccatt tctcatccga gaaattactt aacccttcct ggcgctgtac     4080

agtcatcttt tattctattt cctctttgct gtttgtagta gagacatttt gaatgaaact     4140

tggcactgct tgattcaaaa ctgtggaaac cagatctgtt tagtctcctg tttgtatgcg     4200

tttgctaatg gtagctaaat aaccagtttt tgttgtaaat gcaccaattc tgaaggcact     4260

ttatgtacta catggaggtc atatctggtt ttgtttttat ttttttatca tgaacattaa     4320

atgtgatgat gatttctttt ccctgcacac atctttccgg tgcaatatct atcaattgtg     4380

aatctggctg ctggtgtata aaaacctgga tgtaaagctg agcctacaga cctgtcctca     4440

ccaactgttt tgtgatttct actcaactac aaagatttat ttaatgtact cttaatctaa     4500

ctgagttttg ttaccaatga cctgttgcat gcttcaatac cgtgtactgc ctgagttgtg     4560

cctcttgtgt gctagattaa aagtgagaca gagacttgac ttgatcctct gagctcaagc     4620

tattgagctg gtagtggcag aggactgagg gtacctgcac agtttgattc ttttccacgt     4680

gtaagtctcc attgcagaat tgtcgtgctt tgagaaaaca cctgaggcag tgtgggagtt     4740

gaacgaccct gctgtccttt ttaacctgtg ttgtcctaga ccctgtcggg gcagtcaggg     4800

gacactagag atttgatctc atgcgagtca tcaataggac aaaaaagttg tggtttgggg     4860

aggtctgttt gttacataaa aaggaccttt cggtgtaaga aattgccgtt tttaccctgc     4920

cctggctggc atgtgagaag ccatggaagg ttgtggttgt aaatgagttg tctaaagggg     4980

tgcagaggcc tgaggtttct aaaagaaggt agatttctac agagctgagt gttggttcct     5040

ttttcttatt ggttgaaaat tacctggtag tgatcagaaa acttagatgc tatgtaacta     5100

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaattcc cgctcatgag ttttgactat     5160

tggtgagatg ttttccgcta cagttaacat gacaaatgtc tcagtggcaa aaatcccctt     5220

tttgtaagcc cccatagtct agaggcagtt ttctttttaa gaatcatgcc agagcctgag     5280

tcgagcagta tgctttcttg gtttttgaga gtaattgtgt aattgtagag ggagaaatcc     5340

aattctaacc taagaactgg gattcttctg tcatcttgta aaccgtatat tgaaaaaaac     5400

agaatgtcac taaatgcata ttaagtcaag tattggaaag tataaaagaa aaatcattct     5460

gacaatttct aagccagaag caaacaagaa ttactgaaat ctaccccatg aatacttgga     5520

aggcagtaat tgtgagtgac acctcagttc atcaacccct taataatatc agcttaattt     5580

taatgacaac taaatatgct gaagtgagga tttagtattt tttaaaaaag caaaacaagg     5640

ttcagtagtc ctcagcaatt ctccaagttt ctctctttgc ctaaaatggt catagatctt     5700

gatttctctg aatcgtgatg accacaccca gtcatcttca cagcataatt gcaggtggca     5760

gtaaagagag tgtgctgggt aaggagcagt tgctgggtca ttccttgggc cccgacctgc     5820

ccggggagta gccctggggg agagagggca gtgttgccta tcccagaggt cccagcagtc     5880

acactgctct gcaggccggg ctctctttat agccagagaa atcaccttaa tgcagtctct     5940

ttagttgtct gctgaagctg tagttattat gggccactta catgaggctg agaagtacgt     6000

gccggagctc acacactgcc tgttgcggtt ctcttaacat cagttatcac agctgcctgt     6060

gggtcccggg tatttccatt cctgcccctt gttggcccga ggaaggatgt ggaaagagca     6120

cctggtggga tgaaggtcca acagcctgtg cctctccact gctggccctg gagccggcag     6180

cagtgaggca ttcattgtct gtgttgcggt gtattcccag cttcagtgct cttttccttt     6240

ttgcctgaaa tgtttatgct tctctgcagc cagtcctcta acaaatctca agaacaaagg     6300

taagacactt ggtttttgtt tccaggaccc ttcagaaggt gacatcagat attccctaaa     6360

ttcagacaat gagggataca gagcgacttg gcatgtatta tttctcccat gtaaggacaa     6420

agggacagat tattattgtt atttctgaga cagagtcttg ctctgtagct caggctggag     6480

tgcagtggct caatctcagc tcaccacaac ctctgcctcc tggcttcaag cgattcttct     6540

gcctcagcct ccccgaatag ttgggattac aggcacccac caccacgcct ggctaatttt     6600

tgtattttta gtagagatgg tttcaccatg ctggccaggc tggtcttgaa ctcctgacct     6660

caggtgatcc tcccgcctca gccttccaaa gtgctgggat tacaagcatg agccaccgca     6720

cccggcctca cagtgacaga ttctgagaaa cagcatgcaa aacatttgaa ccattttcta     6780

catctcccat tgttgcatag agagtgtgca ccgctgctat cttgccagat ccacactggt     6840

cctcccgaaa gccaggttca tacacagcaa ctttttaatt attctaacag ttacccatta     6900

acagtcgact cctgtatttc tgagagtctt gtactcacct ctgaaattta aaaacgtata     6960

aagagagcct gggttaatca gttctgcagc ccctacgtga cactgtgcta gttctccttc     7020

ttctgtctcc tccttaccct ggccctgcac ccctgtactt aagagggaga ggtgggaggt     7080

gctgtctggt atcatttgct gcctcgccag tagagggtgc cgctgtgcag ggtaactgcc     7140

cgcctgctcc cttcctgacc tcccctgacc ccgaagatca ctacctctgt cattcaggca     7200

ttggggtaca tcctgataag tcgtgtcaga actgccaatt tcaggactga gatgtgtttt     7260

taaaaaacaa atccttataa actccacttt gtactttaga ttttaaaact ggggaaaaat     7320

gtgatattct ttggaccact tttttaattt atataagcct taatgaacag tgtctataca     7380

tttgcataca cacaccccca ccccagagtg ttctcagtat gtcagagaaa gtgccacagc     7440

attaggacgg gagcttggag aacgttttct agaaaagggt tagcttcctg ttggcatgaa     7500

attttccaag caaacctcat taaacatctg ttgtttgtta aagatgttcc actgaaagca     7560

acgcatgttt caaaggcacg tctttccgtt cgttggtttt ctgtgtgtaa ggagtagcat     7620

tgctgttggc gcctaacctc gcgtgcactg cattctcaac cccgtaccag tgcatcatca     7680

gaagccttcc tcgtgaccat aactctgtgt ctgcagatat gtgttcccgt gtaagccagt     7740

tttccccttt tactcagact gatttcacct agattgtcac ggtttccttc atgttaactt     7800

tgcgtgactt tgttcttcct ttactactct gtatgtaata tatatacata tatacgtaca     7860

tatgctgtcc aaatatattt gtatatattt gtatagcatt tttacacctt tattgagtaa     7920

tctggtttcg aaaggaggtg agagtttagt cccttctgca gttttctcca agctgtgtcc     7980

tgtgaatttc aacccttgga gcctaagaaa accctaggaa gatgatgtta atttgctgtc     8040

atttcctaat tcaggatcta tcatcaaatg aaacatgaaa aaaacagtga cttttaaggt     8100

gaaaagagtt tcaagcattc caaataaatt atcaatgttt cataactttt tattataaac     8160

ccacctccta ataggaagcc aagtactatt tgatacagtg gtaaaaacca aactaccttg     8220

aattttttta aggcaactta tgaataatgc tcattttcac agtcagaata gctttaaaat     8280

atggttgaat ttgatacaca caggaagttt tcttgaagaa caatcctttc gcttttcttt     8340

tttcttgaga gatctaaaga gaaactgtag attgttttcc tgacagcaaa agactaatgt     8400

gacaaaatga agtcattgta aagaagcgat gcaacttgtc aaatatttaa taaagaatta     8460

tggaagctgg aacattttct ac                                              8482


<210>  360
<211>  975
<212>  PRT
<213>  Homo Sapiens

<400>  360

Met Ala Thr Gly Leu Gly Glu Pro Val Tyr Gly Leu Ser Glu Asp Glu 
1               5                   10                  15      


Gly Glu Ser Arg Ile Leu Arg Val Lys Val Val Ser Gly Ile Asp Leu 
            20                  25                  30          


Ala Lys Lys Asp Ile Phe Gly Ala Ser Asp Pro Tyr Val Lys Leu Ser 
        35                  40                  45              


Leu Tyr Val Ala Asp Glu Asn Arg Glu Leu Ala Leu Val Gln Thr Lys 
    50                  55                  60                  


Thr Ile Lys Lys Thr Leu Asn Pro Lys Trp Asn Glu Glu Phe Tyr Phe 
65                  70                  75                  80  


Arg Val Asn Pro Ser Asn His Arg Leu Leu Phe Glu Val Phe Asp Glu 
                85                  90                  95      


Asn Arg Leu Thr Arg Asp Asp Phe Leu Gly Gln Val Asp Val Pro Leu 
            100                 105                 110         


Ser His Leu Pro Thr Glu Asp Pro Thr Met Glu Arg Pro Tyr Thr Phe 
        115                 120                 125             


Lys Asp Phe Leu Leu Arg Pro Arg Ser His Lys Ser Arg Val Lys Gly 
    130                 135                 140                 


Phe Leu Arg Leu Lys Met Ala Tyr Met Pro Lys Asn Gly Gly Gln Asp 
145                 150                 155                 160 


Glu Glu Asn Ser Asp Gln Arg Asp Asp Met Glu His Gly Trp Glu Val 
                165                 170                 175     


Val Asp Ser Asn Asp Ser Ala Ser Gln His Gln Glu Glu Leu Pro Pro 
            180                 185                 190         


Pro Pro Leu Pro Pro Gly Trp Glu Glu Lys Val Asp Asn Leu Gly Arg 
        195                 200                 205             


Thr Tyr Tyr Val Asn His Asn Asn Arg Thr Thr Gln Trp His Arg Pro 
    210                 215                 220                 


Ser Leu Met Asp Val Ser Ser Glu Ser Asp Asn Asn Ile Arg Gln Ile 
225                 230                 235                 240 


Asn Gln Glu Ala Ala His Arg Arg Phe Arg Ser Arg Arg His Ile Ser 
                245                 250                 255     


Glu Asp Leu Glu Pro Glu Pro Ser Glu Gly Gly Asp Val Pro Glu Pro 
            260                 265                 270         


Trp Glu Thr Ile Ser Glu Glu Val Asn Ile Ala Gly Asp Ser Leu Gly 
        275                 280                 285             


Leu Ala Leu Pro Pro Pro Pro Ala Ser Pro Gly Ser Arg Thr Ser Pro 
    290                 295                 300                 


Gln Glu Leu Ser Glu Glu Leu Ser Arg Arg Leu Gln Ile Thr Pro Asp 
305                 310                 315                 320 


Ser Asn Gly Glu Gln Phe Ser Ser Leu Ile Gln Arg Glu Pro Ser Ser 
                325                 330                 335     


Arg Leu Arg Ser Cys Ser Val Thr Asp Ala Val Ala Glu Gln Gly His 
            340                 345                 350         


Leu Pro Pro Pro Ser Ala Pro Ala Gly Arg Ala Arg Ser Ser Thr Val 
        355                 360                 365             


Thr Gly Gly Glu Glu Pro Thr Pro Ser Val Ala Tyr Val His Thr Thr 
    370                 375                 380                 


Pro Gly Leu Pro Ser Gly Trp Glu Glu Arg Lys Asp Ala Lys Gly Arg 
385                 390                 395                 400 


Thr Tyr Tyr Val Asn His Asn Asn Arg Thr Thr Thr Trp Thr Arg Pro 
                405                 410                 415     


Ile Met Gln Leu Ala Glu Asp Gly Ala Ser Gly Ser Ala Thr Asn Ser 
            420                 425                 430         


Asn Asn His Leu Ile Glu Pro Gln Ile Arg Arg Pro Arg Ser Leu Ser 
        435                 440                 445             


Ser Pro Thr Val Thr Leu Ser Ala Pro Leu Glu Gly Ala Lys Asp Ser 
    450                 455                 460                 


Pro Val Arg Arg Ala Val Lys Asp Thr Leu Ser Asn Pro Gln Ser Pro 
465                 470                 475                 480 


Gln Pro Ser Pro Tyr Asn Ser Pro Lys Pro Gln His Lys Val Thr Gln 
                485                 490                 495     


Ser Phe Leu Pro Pro Gly Trp Glu Met Arg Ile Ala Pro Asn Gly Arg 
            500                 505                 510         


Pro Phe Phe Ile Asp His Asn Thr Lys Thr Thr Thr Trp Glu Asp Pro 
        515                 520                 525             


Arg Leu Lys Phe Pro Val His Met Arg Ser Lys Thr Ser Leu Asn Pro 
    530                 535                 540                 


Asn Asp Leu Gly Pro Leu Pro Pro Gly Trp Glu Glu Arg Ile His Leu 
545                 550                 555                 560 


Asp Gly Arg Thr Phe Tyr Ile Asp His Asn Ser Lys Ile Thr Gln Trp 
                565                 570                 575     


Glu Asp Pro Arg Leu Gln Asn Pro Ala Ile Thr Gly Pro Ala Val Pro 
            580                 585                 590         


Tyr Ser Arg Glu Phe Lys Gln Lys Tyr Asp Tyr Phe Arg Lys Lys Leu 
        595                 600                 605             


Lys Lys Pro Ala Asp Ile Pro Asn Arg Phe Glu Met Lys Leu His Arg 
    610                 615                 620                 


Asn Asn Ile Phe Glu Glu Ser Tyr Arg Arg Ile Met Ser Val Lys Arg 
625                 630                 635                 640 


Pro Asp Val Leu Lys Ala Arg Leu Trp Ile Glu Phe Glu Ser Glu Lys 
                645                 650                 655     


Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Phe Phe Leu Leu Ser 
            660                 665                 670         


Lys Glu Met Phe Asn Pro Tyr Tyr Gly Leu Phe Glu Tyr Ser Ala Thr 
        675                 680                 685             


Asp Asn Tyr Thr Leu Gln Ile Asn Pro Asn Ser Gly Leu Cys Asn Glu 
    690                 695                 700                 


Asp His Leu Ser Tyr Phe Thr Phe Ile Gly Arg Val Ala Gly Leu Ala 
705                 710                 715                 720 


Val Phe His Gly Lys Leu Leu Asp Gly Phe Phe Ile Arg Pro Phe Tyr 
                725                 730                 735     


Lys Met Met Leu Gly Lys Gln Ile Thr Leu Asn Asp Met Glu Ser Val 
            740                 745                 750         


Asp Ser Glu Tyr Tyr Asn Ser Leu Lys Trp Ile Leu Glu Asn Asp Pro 
        755                 760                 765             


Thr Glu Leu Asp Leu Met Phe Cys Ile Asp Glu Glu Asn Phe Gly Gln 
    770                 775                 780                 


Thr Tyr Gln Val Asp Leu Lys Pro Asn Gly Ser Glu Ile Met Val Thr 
785                 790                 795                 800 


Asn Glu Asn Lys Arg Glu Tyr Ile Asp Leu Val Ile Gln Trp Arg Phe 
                805                 810                 815     


Val Asn Arg Val Gln Lys Gln Met Asn Ala Phe Leu Glu Gly Phe Thr 
            820                 825                 830         


Glu Leu Leu Pro Ile Asp Leu Ile Lys Ile Phe Asp Glu Asn Glu Leu 
        835                 840                 845             


Glu Leu Leu Met Cys Gly Leu Gly Asp Val Asp Val Asn Asp Trp Arg 
    850                 855                 860                 


Gln His Ser Ile Tyr Lys Asn Gly Tyr Cys Pro Asn His Pro Val Ile 
865                 870                 875                 880 


Gln Trp Phe Trp Lys Ala Val Leu Leu Met Asp Ala Glu Lys Arg Ile 
                885                 890                 895     


Arg Leu Leu Gln Phe Val Thr Gly Thr Ser Arg Val Pro Met Asn Gly 
            900                 905                 910         


Phe Ala Glu Leu Tyr Gly Ser Asn Gly Pro Gln Leu Phe Thr Ile Glu 
        915                 920                 925             


Gln Trp Gly Ser Pro Glu Lys Leu Pro Arg Ala His Thr Cys Phe Asn 
    930                 935                 940                 


Arg Leu Asp Leu Pro Pro Tyr Glu Thr Phe Glu Asp Leu Arg Glu Lys 
945                 950                 955                 960 


Leu Leu Met Ala Val Glu Asn Ala Gln Gly Phe Glu Gly Val Asp 
                965                 970                 975 


<210>  361
<211>  2073
<212>  DNA
<213>  Homo Sapiens

<400>  361
agatgccacg ccccatagct ccaccagtca ccgcggcaca gtggccctta agcgaggagc       60

ggcggcgccc gcagcaatca cagcagtgcc gacgtcgtgg gtgtttggtg tgaggctgcg      120

agccgccgcg agttctcacg gtcccgccgg cgccaccacc gcggtcactc accgccgccg      180

ccgccaccac tgccaccacg gtcgcctgcc acaggtgtct gcaattgaac tccaaggtgc      240

agaatggttt ggaaagtagc tgtattcctc agtgtggccc tgggcattgg tgccgttcct      300

atagatgatc ctgaagatgg aggcaagcac tgggtggtga tcgtggcagg ttcaaatggc      360

tggtataatt ataggcacca ggcagacgcg tgccatgcct accagatcat tcaccgcaat      420

gggattcctg acgaacagat cgttgtgatg atgtacgatg acattgctta ctctgaagac      480

aatcccactc caggaattgt gatcaacagg cccaatggca cagatgtcta tcagggagtc      540

ccgaaggact acactggaga ggatgttacc ccacaaaatt tccttgctgt gttgagaggc      600

gatgcagaag cagtgaaggg cataggatcc ggcaaagtcc tgaagagtgg cccccaggat      660

cacgtgttca tttacttcac tgaccatgga tctactggaa tactggtttt tcccaatgaa      720

gatcttcatg taaaggacct gaatgagacc atccattaca tgtacaaaca caaaatgtac      780

cgaaagatgg tgttctacat tgaagcctgt gagtctgggt ccatgatgaa ccacctgccg      840

gataacatca atgtttatgc aactactgct gccaacccca gagagtcgtc ctacgcctgt      900

tactatgatg agaagaggtc cacgtacctg ggggactggt acagcgtcaa ctggatggaa      960

gattcggacg tggaagatct gactaaagag accctgcaca agcagtacca cctggtaaaa     1020

tcgcacacca acaccagcca cgtcatgcag tatggaaaca aaacaatctc caccatgaaa     1080

gtgatgcagt ttcagggtat gaaacgcaaa gccagttctc ccgtccccct acctccagtc     1140

acacaccttg acctcacccc cagccctgat gtgcctctca ccatcatgaa aaggaaactg     1200

atgaacacca atgatctgga ggagtccagg cagctcacgg aggagatcca gcggcatctg     1260

gatgccaggc acctcattga gaagtcagtg cgtaagatcg tctccttgct ggcagcgtcc     1320

gaggctgagg tggagcagct cctgtccgag agagccccgc tcacggggca cagctgctac     1380

ccagaggccc tgctgcactt ccggacccac tgcttcaact ggcactcccc cacgtacgag     1440

tatgcgttga gacatttgta cgtgctggtc aacctttgtg agaagccgta tccgcttcac     1500

aggataaaat tgtccatgga ccacgtgtgc cttggtcact actgaagagc tgcctcctgg     1560

aagcttttcc aagtgtgagc gccccaccga ctgtgtgctg atcagagact ggagaggtgg     1620

agtgagaagt ctccgctgct cgggccctcc tggggagccc ccgctccagg gctcgctcca     1680

ggaccttctt cacaagatga cttgctcgct gttacctgct tccccagtct tttctgaaaa     1740

actacaaatt agggtgggaa aagctctgta ttgagaaggg tcatatttgc tttctaggag     1800

gtttgttgtt ttgcctgtta gttttgagga gcaggaagct catgggggct tctgtagccc     1860

ctctcaaaag gagtctttat tctgagaatt tgaagctgaa acctctttaa atcttcagaa     1920

tgattttatt gaagagggcc gcaagcccca aatggaaaac tgtttttaga aaatatgatg     1980

atttttgatt gcttttgtat ttaattctgc aggtgttcaa gtcttaaaaa ataaagattt     2040

ataacagaac ccaaataaaa aaaaaaaaaa aaa                                  2073


<210>  362
<211>  433
<212>  PRT
<213>  Homo Sapiens

<400>  362

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  363
<211>  3261
<212>  DNA
<213>  Homo Sapiens

<400>  363
gcttggaagc cagcgctgcg ctccccgtgg gaagcgatcg tctcctctgt caactcgcgc       60

ctgggcactt agcccctccc gtttcagggc gccgcctccc cggatggcaa acactataaa      120

gtggcggcga ataaggttcc tcctgctgct ctcggtttag tccaagatca gcgatatcac      180

gcgtcccccg gagcatcgcg tgcaggagcc atggcgcggg agctatacca cgaagagttc      240

gcccgggcgg gcaagcaggc ggggctgcag gtctggagga ttgagaagct ggagctggtg      300

cccgtgcccc agagcgctca cggcgacttc tacgtcgggg atgcctacct ggtgctgcac      360

acggccaaga cgagccgagg cttcacctac cacctgcact tctggctcgg aaaggagtgt      420

tcccaggatg aaagcacagc tgctgccatc ttcactgttc agatggatga ctatttgggt      480

ggcaagccag tgcagaatag agaacttcaa ggatatgagt ctaatgactt tgttagctat      540

ttcaaaggcg gtctgaaata caaggctgga ggcgtggcat ctggattaaa tcatgttctt      600

acgaacgacc tgacagccaa gaggctccta catgtgaagg gtcgtagagt ggtgagagcc      660

acagaagttc cccttagctg ggacagtttc aacaagggtg actgcttcat cattgacctt      720

ggcaccgaaa tttatcagtg gtgtggttcc tcgtgcaaca aatatgaacg tctgaaggca      780

aaccaggtag ctactggcat tcggtacaat gaaaggaaag gaaggtctga actaattgtc      840

gtggaagaag gaagtgaacc ctcagaactt ataaaggtct taggggaaaa gccagagctt      900

ccagatggag gtgatgatga tgacattata gcagacataa gtaacaggaa aatggctaaa      960

ctatacatgg tttcagatgc aagtggctcc atgagagtga ctgtggtggc agaagaaaac     1020

cccttctcaa tggcaatgct gctgtctgaa gaatgcttta ttttggacca cggggctgcc     1080

aaacaaattt tcgtatggaa aggtaaagat gctaatcccc aagagaggaa ggctgcaatg     1140

aagacagctg aagaatttct acagcaaatg aattattcca agaataccca aattcaagtt     1200

cttccagaag gaggtgaaac accaatcttc aaacagtttt ttaaggactg gagagataaa     1260

gatcagagtg atggcttcgg gaaagtttat gtcacagaga aagtggctca aataaaacaa     1320

attccctttg atgcctcaaa attacacagt tctccgcaga tggcagccca gcacaatatg     1380

gtggatgatg gttctggcaa agtggagatt tggcgtgtag aaaacaatgg taggatccaa     1440

gttgaccaaa actcatatgg tgaattctat ggtggtgact gctacatcat actctacacc     1500

tatcccagag gacagattat ctacacgtgg caaggagcaa atgccacacg agatgagctg     1560

acaacatctg cgttcctgac tgttcagttg gatcggtccc ttggaggaca ggctgtgcag     1620

atccgagtct cccaaggcaa agagcctgtt cacctactga gtttgttcaa agacaaaccg     1680

ctcattattt acaagaatgg aacatcaaag aaaggaggtc aggcacctgc tccccctaca     1740

cgcctctttc aagtccggag aaacctggca tctatcacca gaattgtgga ggttgatgtt     1800

gatgcaaatt cactgaattc taacgatgtt tttgtcctga aactgccaca aaatagtggc     1860

tacatctggg taggaaaagg tgctagccag gaggaggaga aaggagcaga gtatgtagca     1920

agtgtcctaa agtgcaaaac cttaaggatc caagaaggcg aggagccaga ggagttctgg     1980

aattcccttg gagggaaaaa agactaccag acctcaccac tactggaaac ccaggctgaa     2040

gaccatccac ctcggcttta cggctgctct aacaaaactg gaagatttgt tattgaagag     2100

attccaggag agttcaccca ggatgattta gctgaagatg atgtcatgtt actagatgct     2160

tgggaacaga tatttatttg gattggcaaa gatgctaatg aagttgagaa aaaagaatct     2220

ctgaagtctg ccaaaatgta ccttgagaca gacccttctg gaagagacaa gaggacacca     2280

attgtcatca taaaacaggg ccatgagcca cccacattca caggctggtt cctgggctgg     2340

gattccagca agtggtaaat tggtatttgt aaaaagcaaa caaacattac aaggcagtta     2400

tctcattgct gttttgggag aggaacggga aaagcttttt gcttatttgt cttttgaaaa     2460

ttaaggctgg gcgcggtggc tcacacctgt aatcccagca ctttgagagg atgaggtagg     2520

cggatcactg gggtcaggat ttcgagacca gcctggccaa catggcgaaa cctcgcctct     2580

actaaaaata caaaaaaatt agctgcgcgt ggtggtgcac gcctgtagtc cctgctactt     2640

ggaaggctga gacaggaaaa ttgcttgaac ccaggaggct gaggttgcag tgagccagga     2700

ttgcgccacc acactccagc ctgggcaaca gagactctgt ctcaaaaaaa aaaaaaaaaa     2760

aaattaacct caaccaaacg cctatttttt aatgcttagt tttggcttga aattcttctt     2820

cacctggagt tttcttacgt taatacatta aaataacctg aaggaaactt tcgttatggg     2880

ccaatattag ctcttatgga aactgattta tatctttttt atgacctttc aaaagtaaaa     2940

tactatgcat aatctagaaa gatttgtcag ataggaaatt ttataatgca ttagccatta     3000

gtcagagttg ttttttaaca tgccagagaa aaagttgtaa tgccttggaa gttattctct     3060

tttctataga ttgtgttcaa aagatgtgta tacttgcaat aaggtttatg ttaaggtggc     3120

tttaacaatt ggttgctatt ttccttcttt agtcaatatg actttgatgt cattaactgc     3180

taagtgttat tttctaagag gaattttatc ttttttttaa ccttattaaa agcctttgaa     3240

aacacaaaaa aaaaaaaaaa a                                               3261


<210>  364
<211>  715
<212>  PRT
<213>  Homo Sapiens

<400>  364

Met Ala Arg Glu Leu Tyr His Glu Glu Phe Ala Arg Ala Gly Lys Gln 
1               5                   10                  15      


Ala Gly Leu Gln Val Trp Arg Ile Glu Lys Leu Glu Leu Val Pro Val 
            20                  25                  30          


Pro Gln Ser Ala His Gly Asp Phe Tyr Val Gly Asp Ala Tyr Leu Val 
        35                  40                  45              


Leu His Thr Ala Lys Thr Ser Arg Gly Phe Thr Tyr His Leu His Phe 
    50                  55                  60                  


Trp Leu Gly Lys Glu Cys Ser Gln Asp Glu Ser Thr Ala Ala Ala Ile 
65                  70                  75                  80  


Phe Thr Val Gln Met Asp Asp Tyr Leu Gly Gly Lys Pro Val Gln Asn 
                85                  90                  95      


Arg Glu Leu Gln Gly Tyr Glu Ser Asn Asp Phe Val Ser Tyr Phe Lys 
            100                 105                 110         


Gly Gly Leu Lys Tyr Lys Ala Gly Gly Val Ala Ser Gly Leu Asn His 
        115                 120                 125             


Val Leu Thr Asn Asp Leu Thr Ala Lys Arg Leu Leu His Val Lys Gly 
    130                 135                 140                 


Arg Arg Val Val Arg Ala Thr Glu Val Pro Leu Ser Trp Asp Ser Phe 
145                 150                 155                 160 


Asn Lys Gly Asp Cys Phe Ile Ile Asp Leu Gly Thr Glu Ile Tyr Gln 
                165                 170                 175     


Trp Cys Gly Ser Ser Cys Asn Lys Tyr Glu Arg Leu Lys Ala Asn Gln 
            180                 185                 190         


Val Ala Thr Gly Ile Arg Tyr Asn Glu Arg Lys Gly Arg Ser Glu Leu 
        195                 200                 205             


Ile Val Val Glu Glu Gly Ser Glu Pro Ser Glu Leu Ile Lys Val Leu 
    210                 215                 220                 


Gly Glu Lys Pro Glu Leu Pro Asp Gly Gly Asp Asp Asp Asp Ile Ile 
225                 230                 235                 240 


Ala Asp Ile Ser Asn Arg Lys Met Ala Lys Leu Tyr Met Val Ser Asp 
                245                 250                 255     


Ala Ser Gly Ser Met Arg Val Thr Val Val Ala Glu Glu Asn Pro Phe 
            260                 265                 270         


Ser Met Ala Met Leu Leu Ser Glu Glu Cys Phe Ile Leu Asp His Gly 
        275                 280                 285             


Ala Ala Lys Gln Ile Phe Val Trp Lys Gly Lys Asp Ala Asn Pro Gln 
    290                 295                 300                 


Glu Arg Lys Ala Ala Met Lys Thr Ala Glu Glu Phe Leu Gln Gln Met 
305                 310                 315                 320 


Asn Tyr Ser Lys Asn Thr Gln Ile Gln Val Leu Pro Glu Gly Gly Glu 
                325                 330                 335     


Thr Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Arg Asp Lys Asp Gln 
            340                 345                 350         


Ser Asp Gly Phe Gly Lys Val Tyr Val Thr Glu Lys Val Ala Gln Ile 
        355                 360                 365             


Lys Gln Ile Pro Phe Asp Ala Ser Lys Leu His Ser Ser Pro Gln Met 
    370                 375                 380                 


Ala Ala Gln His Asn Met Val Asp Asp Gly Ser Gly Lys Val Glu Ile 
385                 390                 395                 400 


Trp Arg Val Glu Asn Asn Gly Arg Ile Gln Val Asp Gln Asn Ser Tyr 
                405                 410                 415     


Gly Glu Phe Tyr Gly Gly Asp Cys Tyr Ile Ile Leu Tyr Thr Tyr Pro 
            420                 425                 430         


Arg Gly Gln Ile Ile Tyr Thr Trp Gln Gly Ala Asn Ala Thr Arg Asp 
        435                 440                 445             


Glu Leu Thr Thr Ser Ala Phe Leu Thr Val Gln Leu Asp Arg Ser Leu 
    450                 455                 460                 


Gly Gly Gln Ala Val Gln Ile Arg Val Ser Gln Gly Lys Glu Pro Val 
465                 470                 475                 480 


His Leu Leu Ser Leu Phe Lys Asp Lys Pro Leu Ile Ile Tyr Lys Asn 
                485                 490                 495     


Gly Thr Ser Lys Lys Gly Gly Gln Ala Pro Ala Pro Pro Thr Arg Leu 
            500                 505                 510         


Phe Gln Val Arg Arg Asn Leu Ala Ser Ile Thr Arg Ile Val Glu Val 
        515                 520                 525             


Asp Val Asp Ala Asn Ser Leu Asn Ser Asn Asp Val Phe Val Leu Lys 
    530                 535                 540                 


Leu Pro Gln Asn Ser Gly Tyr Ile Trp Val Gly Lys Gly Ala Ser Gln 
545                 550                 555                 560 


Glu Glu Glu Lys Gly Ala Glu Tyr Val Ala Ser Val Leu Lys Cys Lys 
                565                 570                 575     


Thr Leu Arg Ile Gln Glu Gly Glu Glu Pro Glu Glu Phe Trp Asn Ser 
            580                 585                 590         


Leu Gly Gly Lys Lys Asp Tyr Gln Thr Ser Pro Leu Leu Glu Thr Gln 
        595                 600                 605             


Ala Glu Asp His Pro Pro Arg Leu Tyr Gly Cys Ser Asn Lys Thr Gly 
    610                 615                 620                 


Arg Phe Val Ile Glu Glu Ile Pro Gly Glu Phe Thr Gln Asp Asp Leu 
625                 630                 635                 640 


Ala Glu Asp Asp Val Met Leu Leu Asp Ala Trp Glu Gln Ile Phe Ile 
                645                 650                 655     


Trp Ile Gly Lys Asp Ala Asn Glu Val Glu Lys Lys Glu Ser Leu Lys 
            660                 665                 670         


Ser Ala Lys Met Tyr Leu Glu Thr Asp Pro Ser Gly Arg Asp Lys Arg 
        675                 680                 685             


Thr Pro Ile Val Ile Ile Lys Gln Gly His Glu Pro Pro Thr Phe Thr 
    690                 695                 700                 


Gly Trp Phe Leu Gly Trp Asp Ser Ser Lys Trp 
705                 710                 715 


<210>  365
<211>  1695
<212>  DNA
<213>  Homo Sapiens

<400>  365
gaggcacaga taaagataag ttttactgtc atgctgcttt taacataaca gagcaacatc       60

acctaggaaa aaagtttgta ggaggatttt taatccatat atttgtctta tggctagata      120

aagatttctc tgaaaaaaag aagcatgtca ggaatctctg ggtgcccctt tttcctctgg      180

ggacttctag cattgttggg cttggctttg gttatatcac tgatcttcaa tatttcccac      240

tatgtggaaa agcaacgaca agataaaatg tacagctact ccagtgacca caccagggtt      300

gatgagtatt atattgaaga cacaccaatt tatggtaact tagatgatat gatttcagaa      360

ccaatggatg aaaattgcta tgaacaaatg aaagcccgac cagagaaatc tgtaaataag      420

atgcaggaag ccaccccatc tgcacaggca accaatgaaa cacagatgtg ctacgcctca      480

cttgatcaca gcgttaaggg gaagcgtaga aagcccagga aacagaatac tcatttctca      540

gacaaggatg gagatgagca actacatgca atagatgcca gcgtttctaa gaccacctta      600

gtagacagtt tctccccaga aagccaggca gtagaggaaa acattcatga tgatcccatc      660

agactgtttg gattgatccg tgctaagaga gaacctataa actagctgga ccatgatcta      720

gttcaatgat ttggctccta ttgaagatgg cttctaagaa aacaagatgc acagaggaca      780

cagaaggact tggcagcagg gtgatgacct gatcatttgt tgatgggatg gtggcttacc      840

tcttattcac agcttacact tatgcatgcc aaatgtaagg ccatgaaaat cagtatttca      900

aataacttaa aaaatgcttt actactaaaa tgtaaaaaat taatgtgctc acctcggcag      960

cacatatact aaaaattaat aagacccagc ttgaaaattg agcctgataa caagattaca     1020

aattcacaat acctaatact tagggaaata taaaaattta agcatgaatg cgttctggaa     1080

cacgttagaa gaaaaataaa agccaatgag ttttttttta attctccttt ctcaccaatg     1140

ggcaatagcc cataattgaa ataaatttct gattgaaagg tataggaaac attaaaatgc     1200

attactaaga gaagtaatat aattttctta caaagtattt ttcccaaaga tagctttact     1260

atttcaaaaa ttgtcaaatt aatgcatgct ccttacaaca aacaaatatc aaaaagagtt     1320

taggaattct actagccaga gatagtcact tggagaaact ttctatatat ccttctaaat     1380

atttttctgg gcatgcttat gtatgtacat cagttgtttc tttttatttt gaaccaaaaa     1440

tgtggtttct tttgtacaca ttacttaaac tttctttcca gtcaacaata tattgtggat     1500

ttattttcac tgttatattt aactatatat aaatacgcat atattgtaat tttaatgtct     1560

gcttagcacc ccactgataa ccaaatcaca gtttatttaa ataattttaa tgacttttca     1620

aaaacaattt attgatgcaa aaagcaaggt tgagatgaca atgtttcttt caataattaa     1680

aaaatactgc ttcac                                                      1695


<210>  366
<211>  186
<212>  PRT
<213>  Homo Sapiens

<400>  366

Met Ser Gly Ile Ser Gly Cys Pro Phe Phe Leu Trp Gly Leu Leu Ala 
1               5                   10                  15      


Leu Leu Gly Leu Ala Leu Val Ile Ser Leu Ile Phe Asn Ile Ser His 
            20                  25                  30          


Tyr Val Glu Lys Gln Arg Gln Asp Lys Met Tyr Ser Tyr Ser Ser Asp 
        35                  40                  45              


His Thr Arg Val Asp Glu Tyr Tyr Ile Glu Asp Thr Pro Ile Tyr Gly 
    50                  55                  60                  


Asn Leu Asp Asp Met Ile Ser Glu Pro Met Asp Glu Asn Cys Tyr Glu 
65                  70                  75                  80  


Gln Met Lys Ala Arg Pro Glu Lys Ser Val Asn Lys Met Gln Glu Ala 
                85                  90                  95      


Thr Pro Ser Ala Gln Ala Thr Asn Glu Thr Gln Met Cys Tyr Ala Ser 
            100                 105                 110         


Leu Asp His Ser Val Lys Gly Lys Arg Arg Lys Pro Arg Lys Gln Asn 
        115                 120                 125             


Thr His Phe Ser Asp Lys Asp Gly Asp Glu Gln Leu His Ala Ile Asp 
    130                 135                 140                 


Ala Ser Val Ser Lys Thr Thr Leu Val Asp Ser Phe Ser Pro Glu Ser 
145                 150                 155                 160 


Gln Ala Val Glu Glu Asn Ile His Asp Asp Pro Ile Arg Leu Phe Gly 
                165                 170                 175     


Leu Ile Arg Ala Lys Arg Glu Pro Ile Asn 
            180                 185     


<210>  367
<211>  8058
<212>  DNA
<213>  Homo Sapiens

<400>  367
agtcatcttc aactcggcag gaacccacaa gtgtgcatgt gtggctcgga ggcttcagct       60

ggggccccgc cctcgtcccc aggcgcacac tgacacacgc agcccagacc cggcccgagc      120

gggctcctgc cctcggcgtg gcttctctcc agccgggagt cccagggcca gctagcctcc      180

tcccctaaag gggacggcct gtcagcgcag tgccagagtc cagcaccggg aggaaagttt      240

cggagtgcgg agggagttgg ggccgccgga ggagaagagt ctccactcct agtttgttct      300

gccgtcgccg cgtcccaggg accccttgtc ccgaagcgca cggcagcggg ggggacttca      360

gccctccagg cggggtgggt tccaggtccg ggtccgaggc gggcgctgga ggctcggccc      420

caggccggag aggaactcct ttcgcgagct gtcgccgtgg gcccgcattg tctgcaggaa      480

ctctccggaa tcgggagggg gaggactgga tcgcgcttcc actgggattc gtcaagagtt      540

ccggcggcag ctgcggcggt ggcggagact ccctttgtcc tctcaggacc tccctctctc      600

cctccctgtc agctggtggg tcccgctgcc gcaggcgccg gcgtctcagc tgctcgccgc      660

cccccacccc agagtgcgtg ccgggtgact cccgccacct ttgcgaccct cctgagctta      720

ggggactgcg agcgggaggg agtctcaggc ccccggccgc aggatggtgg cggagcggtc      780

cccggcccgc agccccggga gctggctgtt ccccgggctg tggctgttgg tgctcagcgg      840

tcccgggggg ctgctgcgcg cccaggagca gccctcctgc agaagagcct ttgatctcta      900

cttcgtcctg gacaagtctg ggagtgtggc aaataactgg attgaaattt ataatttcgt      960

acagcaactt gcggagagat ttgtgagccc tgaaatgaga ttatctttca ttgtgttttc     1020

ttctcaagca actattattt tgccattaac tggagacaga ggcaaaatca gtaaaggctt     1080

ggaggattta aaacgtgtta gtccagtagg agagacatat atccatgaag gactaaagct     1140

agcgaatgaa caaattcaga aagcaggagg cttgaaaacc tccagtatca taattgctct     1200

gacagatggc aagttggacg gtctggtgcc atcatatgca gagaaagagg caaagatatc     1260

caggtcactt ggggctagtg tttattgtgt tggtgtcctt gattttgaac aagcacagct     1320

tgaaagaatt gctgattcca aggagcaagt tttccctgtc aaaggtggat ttcaggctct     1380

taaaggaata attaattcta tactagctca gtcatgtact gaaatcctag aattgcagcc     1440

ctcaagtgtc tgtgtggggg aggaatttca gattgtctta agtggaagag gattcatgct     1500

gggcagtcgg aatggcagtg ttctctgcac ttacactgta aatgaaacat atacaacgag     1560

tgtaaaacca gtaagtgtac agcttaattc tatgctttgt cctgcaccta tcctgaataa     1620

agctggagaa actcttgatg tttcagtgag ctttaatgga ggaaaatctg tcatttcagg     1680

atcattaatt gtcacagcca cagaatgttc taacgggatc gcagccatca ttgttatttt     1740

ggtgttactg ctactcctgg ggatcggttt gatgtggtgg ttttggcccc tttgctgcaa     1800

agtggttatt aaggatcctc caccaccacc cgcccctgca ccaaaagagg aggaagaaga     1860

acctttgcct actaaaaagt ggccaactgt ggatgcttcc tattatggtg gtcgaggggt     1920

tggaggaatt aaaagaatgg aggttcgttg gggtgataaa ggatctactg aggaaggtgc     1980

aaggctagag aaagccaaaa atgctgtggt gaagattcct gaagaaacag aggaacccat     2040

caggcctaga ccacctcgac ccaaacccac acaccagcct cctcagacaa aatggtacac     2100

cccaattaag ggtcgtcttg atgctctctg ggctttgttg aggcggcagt atgaccgggt     2160

ttctttgatg cgacctcagg aaggagatga gggccggtgc ataaacttct cccgagttcc     2220

atctcagtaa aagggaagca ggaagaccaa gaaggtacga agatggcaca ttttcacata     2280

gctgattttc aaccaaatga aaaaaatcaa gtgcatttca gaagcttttg gaagagcagc     2340

ttaattcctc tcagtcggga aatgttttct ctgccttctg ctttgcttgc accaaacatt     2400

tctaaacact tgttctgcca tctacatggg aggtgatgaa actcagtggt aactcatgat     2460

ttatgacatt gaaaataaag aggaacattg acctgcagac tatggtttgt acaagaaagt     2520

ttgtttgaat gtgtagaaga ggaaaaagca acaacagcaa caacacgaag atgataccaa     2580

aacaaggacc acaaaacaac tagccatgat gggagacagg agttttttac atggaaacat     2640

ggcacttgtg tttttatgtg gcaagatctt tatccatagg cagagtatga aatttcccac     2700

caggctaagc aaataaagaa gtccattgcc ttatagctat gtcagatcac agaatccttc     2760

caagtgctct atcacagtgt gccttatggg aagtttctga ctggaaaatc ttgtcattct     2820

aacactgaaa agtgcacacg catgacaaaa tgtagacaag atgcctcaag gtattggtag     2880

caagcaagat tttgcccttt agttttcgaa gacacctttc tttcattatg cactcgggac     2940

aagaaaatta atagagcgtt attccacaga aggcctctag ccagagatct tgagtgtagt     3000

gcaagggact cattttttgc gaacttgtcc ctgtgactag tagattcccc cttttcctgt     3060

gtttaggatt tagtagtgca taaagcatta atatccataa acatacctag aagtttgttt     3120

tgcttttaat ttaaaggaag cagtaaccac aaagcttccg ctcagggttt tttctttctt     3180

caagtctcca agggctcttc agcgtcacaa gccagcaact ctctttgcat taaaatttca     3240

aagtttaatt aatataatta aaagcaacag caagcagcag cctgtgaaga ttttgctcat     3300

cttttttatg ccttttgaca ttgaatgacc tattactgta tgcgcattac ttggattttg     3360

aggggcactc taccttggtt atgattcagt agaggaaaaa gaccaccttt cttcaattta     3420

caaattaaat cttctggagg gtcgctatca caaaacattg acgatgtatg tattataatt     3480

ttttagaaaa accaccatcg tgtcacgtcg acgatgccaa attatgttag cgtgagcaga     3540

aacaccgtgg gggaggaagg cagcagctga agaaaaaagc tcaaatgatc tagtcacttt     3600

cgatactgta cttcagatgc gaaatggata ttcgagtgga aacctgacaa agtgcgcctg     3660

ctttgatgtg aactggtata gacaatgacc agtggctggg tcagtgggat gtctctctgt     3720

gagcacaaag gcttatcaaa tgacactaaa aataagttca acaaccatca cattggaagg     3780

gagaaggcga acatttcatg tttggcgggc atgtgagtgc acaagatgga aagagcgatt     3840

ggagcatcct ggtataatta cccccattgt gctcttaatg gaaatttcaa aggacgggag     3900

tattctgttg gttggtgtcc aggtttgtgg cactgttcca agaggcctta cacacacaca     3960

caaatatata attttctata catatatatc ctctagcttg aaacttttgc tcaagtttat     4020

ttatgtcact ggctggctgg atccaaagtc atgtgtccac acattcataa ataaaaattt     4080

tacctatgcc tgtgctacca tttctttaag cccacataaa gctaatgcct tcttgggttg     4140

aatatgcagt tgttatgctt agtttcaggg atggaattct attcagttcc aaaatgtccc     4200

tcatgttcac agatgatact attggcagta gctgcatatg caagtgtaac ttggaagcct     4260

gatatagtat acccaaccct ttctgcaatg agttattgta tccctttgtt ctgcatttgc     4320

atctggaaca agacctaatg tggcttcctt aaatgggcac ttcatttctg atgagtgcac     4380

accaattatt gctattttaa tatcattgag aatactacag aagctaaggc tatgtttctt     4440

tggtaactac ttcaaatttc tctagaatta tgtagcatac ttacattttg ctgcatgaac     4500

aatgaaaatt aacctctgcc tttaaatgga aaaataactt tctgtagatt gttatacagc     4560

tactatgaag agctcttaat gaagaggaag tggcagtggt ctatatgtag actgaaaaaa     4620

tatcattaat aaagttcaaa gactgatgga atttcattgc ccttaaagat atgaaccaga     4680

tctgttttat gcttttctcc aattatacta actagcagtt gaaaagaatt tgttttgaag     4740

agtgttattt tcttaccaaa agaccagatc aaaaatccct atacttttcc accaaaaaaa     4800

gattaaaatg aagccatttc tataaattta atggcacttt atattttata tagagaaata     4860

gcttctgttt gattttctgg acaccatgtc agtcaagatc tactttctgt gtaaaaatga     4920

ataagtcttg cacataatcc attcgtgttg cataaggttg caaaaacaat taagtgggaa     4980

atgactccta acttatgtgt ctactctgcc tagaaagaaa gttttgaagg catctatata     5040

tatttcataa caatgtctgt tctttatgga tttgatccat aaatatttat ctatctgaaa     5100

actttgatac ttggaatgtt ttccttagag catttggtgc tccaagaaaa aacatttggt     5160

gctaagagtt gcagcactga tgcctttccc taagttaatt ctattttaaa aatttatatt     5220

tccttcccaa tgagatgcag agtaaaattt gagaccctcc attgactagg gagcagcatc     5280

tgtcatctat ggttaattac tattttgaca aaaatataga aggtttaaac ccccatgtat     5340

ttcagattgt tagagaaaga agtagtttgc ttatatttcc cttgaacttt attctaacca     5400

tttaaataat aaattattca atatttgtta taataaatcc ttactagata caagatttgg     5460

gtgtttctgt gaagttaact ttattatcta aatatcacta accattgttt actgctcaga     5520

ggcagataca tttgtttagt ttaaagttga aacaaattct atattgtgga taattaggtg     5580

tttaaaacat tttgatagac cagcttatat atgttatttt tgaaatttaa gaaggcagaa     5640

tgtaattagg tcacatttac aagtagaagg aattataact tcctactcca tgcatatatt     5700

gtatattggt tagcttttac tagcattttc tagcatcaca ttactttaga aagtttttga     5760

gagtttcatt actactggaa aagtttggtg ggtatatgta cacaggaaag aaatatatgc     5820

atcatttcaa tatgaaagga aatacataat ctagaaacat agaataactc ttggtacatc     5880

tgttacatag ttaaggaaag aaacaggcag gtgaggctgg agaatgttgt ctatttgtag     5940

gaaataaagt cagtgcagac gcatattcta gtttagagtt agattaatat tgtgcttagt     6000

gaatttctat gacatatttc tgagaacact ttaatatatt tccacaccta ctggaatcta     6060

attcagtcga tcggataaaa gaaagacttt tttgttgttg tttttgaaaa tccataatgt     6120

agcaggttct gcgctggttt tttaatgtat tttatttttg tgctctcctg ccaaaagaaa     6180

aggctgataa gtaagtacac agtacaacat gtaaatttgt ataaaaatat gcttgtttag     6240

attgctctac aataactata ttaaggtaaa ttgtgtgtgt gtgtgtgaga gagagagaga     6300

gagagagaaa cagagggaga attgactcaa tgtgttttct atgaagagtc ttagcttagg     6360

aatcaggtaa cagagaggtc ctagaccata gacccagcca tcaactagct tgctgatgtt     6420

gaacagatca actctcaacc atagactgaa gatggaatga agatatcaaa agttcctttt     6480

agcactgact agattttttt tctttttttt gaaacagagt ctcactctgt cacccaggct     6540

ggagttcaat ggcatggtct gggctgactg taacctcctc ttcctgggtt caagtgattc     6600

tcatccctca gcctcctgag tagctgggat tacaggcaca taacaccaca cccagctaac     6660

tcttgtattt ttgtagaaat ggggtttcgc tatgttgctc agactggtct caaacacctg     6720

gcctcaagtg atcctcctgc ctcagtctcc caaatgctgt gattacaggc acaagctact     6780

gcaccaggcc tctgactaca tttctattaa tatggttagg ttggaggttt tagtattttt     6840

gtatctcata tttgtatcaa tatgactggc ttctttgtct gtagtgtgtg gtaatattag     6900

ttctgtaaac tgtcagttgc aaaaaaaaaa aataccttga actatagtat atgttgataa     6960

ttagccataa taatttctta gttaatttct tataattaaa tttgtcaaag aggaaactta     7020

cagtttatat ctgatgaaat ctctaaaaag atgggtaaaa cattgggaaa tgtatgcatg     7080

tacttcactc tggtttcata gggttagcaa gtgtcttaaa aacatatata aagaagcaca     7140

gagattgtta ggagatattt atgctcccag ttttaataat tgggatactt tgtataccac     7200

agaaagaaaa attactaaac tcctcttttt ttagtcaaaa ttggaaaaaa agtcttaatt     7260

gacagttact atgcctgtgc tacccatagc aagtattcag tggaaaatac tttactaagt     7320

aagtaatttg aacacagctt aaaatccata gtatgttaca attgctagcc tttcacaaag     7380

tttgcattgt cttaatgtag aaggatactg tgatctaaga attcacaatt ttaaaaagtg     7440

gaacctaaat agggtttcct aattgccatg aagttatttg tatcttagat gaattatatt     7500

tacaacattg taaatgtcag tgggtgatcc aaaataaatt gttaaagtta ttaaaatgta     7560

catttaagta ggtttcagtt tgactagaaa taattggcaa gaaggcaaga actagtcttc     7620

tagagcaggg atcccatccc ccaggtcatg gactggtact ggtccatggc ctgttagaaa     7680

ccaggccaca cagcaggaga tgagtggaaa gcaagtgaaa cttcatgggt atttacagca     7740

attccccgtc gctcgcatta ccacctgagc tgtgtctcct gtgagatcag cagcagcatt     7800

agattctcaa ggagcacaaa cccttttgga actgtgtgtg agggatctaa gttgcgcatt     7860

tcttatgaga atctaatacc tgatgatctg ttgttgtctc ccaccacccc cagatgggac     7920

catctagttg caggaaaaca agctcaggct cccactgatt ctacattata gtgagttgtg     7980

taattatttc attatatata acaatgtaat aataatagaa ataaagtaca taataaatgt     8040

aaaaaaaaaa aaaaaaaa                                                   8058


<210>  368
<211>  488
<212>  PRT
<213>  Homo Sapiens

<400>  368

Met Val Ala Glu Arg Ser Pro Ala Arg Ser Pro Gly Ser Trp Leu Phe 
1               5                   10                  15      


Pro Gly Leu Trp Leu Leu Val Leu Ser Gly Pro Gly Gly Leu Leu Arg 
            20                  25                  30          


Ala Gln Glu Gln Pro Ser Cys Arg Arg Ala Phe Asp Leu Tyr Phe Val 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Ala Asn Asn Trp Ile Glu Ile Tyr Asn 
    50                  55                  60                  


Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr 
                85                  90                  95      


Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val 
            100                 105                 110         


Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn 
        115                 120                 125             


Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile 
    130                 135                 140                 


Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu 
145                 150                 155                 160 


Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val 
                165                 170                 175     


Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser 
            180                 185                 190         


Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly 
        195                 200                 205             


Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu 
    210                 215                 220                 


Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser 
225                 230                 235                 240 


Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr 
                245                 250                 255     


Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val 
            260                 265                 270         


Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly 
        275                 280                 285             


Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile 
    290                 295                 300                 


Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala 
305                 310                 315                 320 


Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu 
                325                 330                 335     


Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro 
            340                 345                 350         


Pro Pro Pro Pro Ala Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu 
        355                 360                 365             


Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg 
    370                 375                 380                 


Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly 
385                 390                 395                 400 


Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val 
                405                 410                 415     


Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg 
            420                 425                 430         


Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile 
        435                 440                 445             


Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp 
    450                 455                 460                 


Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp Glu Gly Arg Cys Ile 
465                 470                 475                 480 


Asn Phe Ser Arg Val Pro Ser Gln 
                485             


<210>  369
<211>  674
<212>  DNA
<213>  Homo Sapiens

<400>  369
acaggacaca gctaggttct gaagcttctg agttctgcag cctcacctct gagaaaacct       60

ctttgccacc aataccatga agctctgcgt gactgtcctg tctctcctcg tgctagtagc      120

tgccttctgc tctctagcac tctcagcacc aatgggctca gaccctccca ccgcctgctg      180

cttttcttac accgcgagga agcttcctcg caactttgtg gtagattact atgagaccag      240

cagcctctgc tcccagccag ctgtggtatt ccaaaccaaa agaggcaagc aagtctgcgc      300

tgaccccagt gagtcctggg tccaggagta cgtgtatgac ctggaactga actgagctgc      360

tcagagacag gaagtcttca gggaaggtca cctgagcctg gatgcttctc catgagccgc      420

atctcctcca tactcaggac tcctctccgc agttcctgtc tcttctctta atgtaatctc      480

ttttatgtgc tgtattattg tattaggtgt tatttccatt atttatatta gtttagccaa      540

aggataagtg tcccctatgg ggatggtcca ctctcactct ttctctgctg ttgcaaatac      600

atggataaca ccgttaattc catgtgtttt cataataaaa ctttaaaata aaatgcaaaa      660

aaaaaaaaaa aaaa                                                        674


<210>  370
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  370

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  371
<211>  4584
<212>  DNA
<213>  Homo Sapiens

<400>  371
tcccacgacc ttggccggcg ccggggccct acacgccaga cctggctcgg ggtgggagtg       60

cagaggcaac caaaaaggaa cccacacctc cctccagggc ccggggcgct gtcagacggg      120

gcagcaacca ggagattccc tgggcctgca ggaagccctt ccgcggaccg aaagattgtt      180

ccccattttg gagatgaaga aactgagact caaagcagct gagtgacctt cccaaggaca      240

cacactgaac tgggcggtga tcaggatctg aatgcacagg gcgggtgttc agcgattgtt      300

tactacgttg aacgtgacct ccaggaaagc agttctggcc gagatcccct gacaacgcaa      360

agcaagaagt aacgtggaag gaggctcccc aagctggctg gccattttgc tgctgtgtgt      420

ggaggtgctg ccagtggcat gcccaaaccc aaagctggaa gaggaataaa ttacaagtgg      480

tcaaggttgc atccttttga gcccaggacc tgcttgtaag ccgagagggt tctctggccc      540

taatctagcc aagcaccatg gagagaatca gtgccttctt cagctctatc tgggacacca      600

tcttgaccaa acaccaagaa ggcatctaca acaccatctg cctgggagtc ctcctgggcc      660

tgccactctt ggtgatcatc acactcctct tcatctgttg ccattgctgc tggagcccac      720

caggcaagag gggccagcag ccagagaaga acaagaagaa gaagaagaag aagaagaaga      780

aggatgaaga agacctctgg atctctgctc aacccaagct tctccagatg gagaagagac      840

catcactgcc tgtttagtta ggcaggaagc agaggtgttt cctttctggg gctaagcctc      900

cttctgacca cacacagaca tttcaggaac ccctgaaata atgcactatg tccatgtcca      960

cagagtaact actcaaccaa ggaacaaacc tcagactaag tgtcccagtg gagggcagtc     1020

ccagggacca cgtggacaat tcttggatac tgtcttggca gctatgtgtc caatagcaat     1080

gctccttact gcagacccag gcatgcctcc cacctgtctc tggcataccc cacatgcaaa     1140

gcacaaagaa catttatcca tacatctcaa tatggttccc aagtgtgtgc acatgcacgt     1200

aacacacaca cacacaaatt caggtagcag gtacgtgggc aagtatattc tgctcatcaa     1260

atggtcattg gctatgtact ttgtgcaggg aagtacatta tctacagtca caaaaatgtc     1320

tcatgggaaa gccttgccag attcagacac atatatacaa tttcctaacc agcaaggccc     1380

ccatacacca tctattccat aaaccactca ggttacagat gcatgctttc ctatttctaa     1440

ctctacacat aaacttttac tggaagtact cataattgga cattccagca acctgctaca     1500

gtccccaccc ttgtgtgtct tgatacagac acaccaagtt tctgtgcctc tgacccctca     1560

cctgtgccaa gatgtttaaa gtgtgatggt tcaaaattca ttgaaagctc ttttcttgta     1620

actcatgaca aagtccgtcc tcattgccac tgagaggtgt ttaatgtgat ccaagacctc     1680

tctgtgaaac attacccccg caaaccactc agcaaagtgc ctttctccaa gcaagaacaa     1740

agagctcttg gtggtgactg ctagaaaatt atggaagccc actcatttat gtcagtggac     1800

tgcaactgtg tacctgtgca atgtttacag atggaaaggg tgaggagatg ctacacctga     1860

gctaggtatc tcctatataa ccaaagtttc cagcagggaa ggaactagac aatcatcagt     1920

gcagtctcac agaaggcaac actggaagtg atgtcataag gttgtgatgt gtgcacggta     1980

tggcacaggt gggatgcaga ggtaacagag tttaaatgaa agtaggatga agctataaag     2040

aggtttattt atatttatat tgaagctcag gcaagtgcct tgcacacagt aggtacttat     2100

aactaactgt ggttactgtt ggatatgtga tgttgttaag ggtaagcttg taatacctca     2160

ccagttctcc ccgagtgatc ttctcttcta agtgagccca ctaattgctg caatggatga     2220

aattgggtgt ttaatgctgg agagcacatg taggtgacac atgtgccttg aggtatgtga     2280

ggacatgtaa attagatcca cagtgagctg aggagggctt tccccgccag agtgaggttg     2340

ggaagcagag ttaatccact tataggatga actgcttggt atttttattg tattgtgact     2400

gtattacaaa gatggacaat tcactccttg ggagcaagtt atgctctaga agtttattta     2460

caaatatgct gggcagctct cttgaaatat tttcccaagg aagctattct acacagtggc     2520

aaaattgcta tctaattaat aatgtagcta aactatgata tttatagtag caaaaaacta     2580

aattctataa gattgcatta aaggaaagat atattctatt tgctcacttg ggctgcttgg     2640

tactcacctg ccctccaggt gtactttagg cctgtggagg gtgggcattt agtggtgacc     2700

cttgcaccag ggttttctaa cagatgaccc tgtgaatcat aatttaaacc tgcatatatt     2760

ttatagccag tcacatttgc cctctcaccc tatatggcca taaactgcct aagcactcag     2820

gcctcccact catcaacccc tttgaccaga gaaagaagca ctctggttct ctatcccctt     2880

gtcacataga gagtttgtca tggggcctct ggctgtgccc ttcacataac agaatgactt     2940

gccatctgcc tgcaccaaac ccagggatgt ggaagacatc tccccacaac tgccactgct     3000

caccaggaca agctgccctt cctgtctcca cctctcagtc cccctagaat ggatggctgg     3060

ggagaggtgg aggctgacag ctgagacgta gtgtcagata tgatctagga gggcggatca     3120

ccgggatccg ggaccataca agtaacatgg tttccatggc aactgcttgc tcctttgaat     3180

taagacagca gtcagttgtc attgccatga caaggcctct atctccaggc acaatgtccc     3240

tgctgtctcc taatccaatg gacttgctct caccccaggg atgaaacacc cagaaactca     3300

cttctcagtc acttccacag ccgatgactc agaagagcca aacccagaat ggggcctctc     3360

ttttccccat cacagactcc cctgacaacc tttcctggcg taactagagg agtcccagtg     3420

caggataggc cctaaacgtt ttgttaaata aacaggtgca tgaaaggagc ctaaggccat     3480

tgttgatatc cactctcttc tttccacttc cttctcatct ttttctccat gttttatgct     3540

tctctgattc cctcttctgc ctgcaccaga ccagccccag ccctttattc ctctccattt     3600

tcactccttc cagcctctgt ccctgaactg ccactggcaa cccatgggac ctcaggacca     3660

gagactgctt gactcatctg gggagggtaa gttcacgggg gacaaaaaaa tgattcctaa     3720

agaagaggct tcctagacca gcacaggctc gagaaagaca tcccctaggc ctggacttct     3780

gagcagcttt agccaggctc cggacggcag ccagaggagg cctttcccca ttgctccttt     3840

ccccattgct caatggattc catgtttctt tttcttgggg ggagcaggga gggagaaagg     3900

tagaaaaatg gcagccacct ttccaagaaa aatataaagg gtccaagctg tatagtattt     3960

gtcagtattt ttttctgtaa aattcaaaca cacacaaaag aaaaatttat ttaaataaaa     4020

tactttgaaa atgaaaagtc ttgatgtagt cagatggtta ctctcttaac attaggtatt     4080

acccccactc agacatcact cagaaatgat caatgcaggg actctttctg tgacacaaat     4140

gtcccagccc tccctggtca ccgccttcgc catggtagag tcataggtct gaggatgagg     4200

aatgtggctg tctcaccctt gcttgcaaaa cagatggcct tggagaccag actccctcaa     4260

aggtgccagc tacaggaaaa atatactgat gttccttggc aacacttaca gaactttcca     4320

tcaatgaggt ccatcaatgg cttcttaaag gaaaaggggg gaaatagcaa aaacctaagg     4380

aagaatggac ctttgagtta aatccagtgt ttgttgggaa aggagggatc aaaaacctct     4440

atagtagcca ctagggcaaa aactgtgtgt atgtgtgtgt gtaagtgtgt gtacactgtt     4500

caatatggtt caatatggta ccaatagcca catgtgacta tttaaattca ttgcaatgaa     4560

ataaaattaa aggtatacta gctc                                            4584


<210>  372
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  372

Ser Glu Gln Ile Asp Asn Asn Met Met Glu Arg Ile Ser Ala Phe Phe 
1               5                   10                  15      


Ser Ser Ile Trp Asp Thr Ile Leu Thr Lys His Gln Glu Gly Ile Tyr 
            20                  25                  30          


Asn Thr Ile Cys Leu Gly Val Leu Leu Gly Leu Pro Leu Leu Val Ile 
        35                  40                  45              


Ile Thr Leu Leu Phe Ile Cys Cys His Cys Cys Trp Ser Pro Pro Gly 
    50                  55                  60                  


Lys Arg Gly Gln Gln Pro Glu Lys Asn Lys Lys Lys Lys Lys Lys Lys 
65                  70                  75                  80  


Lys Lys Lys Asp Glu Glu Asp Leu Trp Ile Ser Ala Gln Pro Lys Leu 
                85                  90                  95      


Leu Gln Met Glu Lys Arg Pro Ser Leu Pro Val 
            100                 105         


<210>  373
<211>  5182
<212>  DNA
<213>  Homo Sapiens

<400>  373
cgcgctggcg ccatggcgga gcaggagagc ctggaattcg gcaaggcaga cttcgtgctg       60

atggacaccg tctccatgcc cgagttcatg gccaacctca ggctcagatt tgaaaaaggg      120

cgcatctata cgttcattgg agaagtcgtc gtttctgtga acccttacaa gttgttgaac      180

atctatggaa gagacacaat tgagcagtat aaaggccgtg agctgtatga gagaccgcct      240

cacctttttg ctattgcgga tgctgcttac aaggctatga agaggcgatc aaaagacact      300

tgtattgtga tatcagggga aagtggagct ggtaaaacgg aagccagtaa gtacattatg      360

cagtatattg cggccatcac caaccccagt cagagagcag aggttgaaag agtgaagaat      420

atgttgctta agtccaactg tgttttggaa gcttttggaa atgccaaaac caaccgtaat      480

gacaactcaa gcaggtttgg aaaatacatg gatatcaact ttgacttcaa gggtgaccct      540

attggtgggc atatcaataa ctacttacta gaaaagtctc gagtgattgt gcaacagcca      600

ggagaaagaa gctttcattc tttctatcag ctactccaag gaggttcaga acaaatgcta      660

cgctctctac atctccagaa atccctttca tcctacaact atattcatgt gggagctcaa      720

ttaaagtctt ctatcaatga tgctgccgaa ttcagagttg ttgctgatgc catgaaagtc      780

attggcttca aacctgagga gatccaaaca gtgtataaga ttttggctgc tattctgcac      840

ttgggaaatt taaaatttgt agtagatggt gacacgcctc ttattgagaa tggcaaagta      900

gtatctatca tagcagaatt gctctctact aagacagata tggttgagaa agcccttctt      960

taccggactg tggccacagg ccgtgacatc attgacaagc agcacacaga acaagaggcc     1020

agctacggca gagacgcctt tgccaaggca atatatgagc gccttttttg ttggatcgtt     1080

actcgcatca atgatattat tgaggtcaag aactatgaca ccacaatcca tgggaaaaac     1140

actgttattg gtgtcttgga tatctatggc tttgaaatct tcgacaacaa cagttttgaa     1200

caattctgta tcaattactg caatgagaaa ctgcagcagc tatttattca gctggttctg     1260

aagcaagaac aagaggaata ccagcgggaa gggatcccct ggaaacatat tgactacttc     1320

aacaatcaga tcattgttga cctcgtggag caacagcaca aagggatcat tgcaatcctt     1380

gatgatgctt gcatgaatgt cggcaaagtc accgatgaaa tgtttcttga agcacttaac     1440

agtaaattgg gcaaacacgc ccatttttcc agccgaaagc tctgtgcctc agacaaaatt     1500

ctggagtttg atcgagattt tcgaattcga cattatgcag gcgatgtagt ctattctgtc     1560

attggtttta ttgacaaaaa taaagatact ttatttcaag atttcaagcg ccttatgtat     1620

aacagttcaa atcctgtgct caagaatatg tggcctgaag gcaaactgag cattacagag     1680

gtgaccaagc gacctctgac tgctgctacc ttgtttaaga attctatgat tgctctagta     1740

gacaaccttg catcaaagga accatattac gttcgttgca tcaaacccaa tgacaagaaa     1800

tctccacaga tatttgatga tgaacgctgc cggcaccaag tagaatatct tggactactg     1860

gaaaatgtga gagtgcgtcg ggcaggattt gccttccgcc agacatacga gaagtttctt     1920

cacaggtata agatgatctc tgaattcacc tggcccaacc atgaccttcc ttcagacaaa     1980

gaggctgtca agaaactaat tgaacggtgt ggttttcagg atgatgtagc ttatgggaag     2040

accaaaattt tcattcgaac accccgaaca ttgtttacct tggaagaact ccgtgcccag     2100

atgctcataa ggattgtcct ctttctacaa aaggtgtggc ggggcaccct ggcccgcatg     2160

cggtacaaaa gaaccaaggc agctctgaca ataatcaggt actaccggcg ctacaaagtg     2220

aagtcgtaca tccacgaggt ggccagacgc ttccatggcg tcaagaccat gcgagactac     2280

gggaagcacg tgaagtggcc aagccctcct aaagttcttc gccgttttga ggaggccctg     2340

cagacgattt tcaatagatg gagagcatcc cagctcatca agagcattcc ggcctcagac     2400

ctgccccagg tcagggcaaa ggttgcagcc gtggaaatgt tgaagggtca aagggctgac     2460

ctcgggctcc agagggcctg ggagggcaac tatcttgctt caaagccaga tacacctcag     2520

acctcaggca cttttgtccc tgttgctaat gaattgaaac ggaaggacaa atacatgaat     2580

gtcctctttt cctgtcacgt ccgtaaggta aatcgattta gtaaggtgga agacagagca     2640

atttttgtca ctgaccgtca cctgtataaa atggatccca ctaaacagta caaggtgatg     2700

aagactatcc ctctatacaa tttgactggt ctgagtgtct ccaatggaaa ggaccaactt     2760

gtagtgttcc atacgaaaga caacaaagac ctcattgtct gcctcttcag caaacagcca     2820

acccatgaga gtcgaattgg agaacttgtt ggagtgctgg tgaatcattt caagagtgag     2880

aagcgccacc ttcaagtgaa cgtcaccaac ccagtacagt gcagcctgca cgggaagaag     2940

tgcaccgtct ccgtggagac gcggctcaac cagccccagc ccgacttcac caagaatcgc     3000

tcgggcttca tcctcagcgt gcccgggaac tgacgccccg cggaggcctg gcccggagcc     3060

cggccacact ccgagtcctg ggtcccagtc cagctgctgc ctcccaaccc atgcccgcta     3120

gaaacctgct gcgagggccc ctcccagagg agccccgccc ctgtaagatt tccttcctgg     3180

ttttctgcct ttggtatcat cttcctctgt ccttactgtc cacggtccct gttcaataag     3240

ccaaagaccc tggtgccccg cccagacccc tgggctgacg tccagaccaa tctcacccca     3300

gaggcaactg gatggtgcct ttagttggtg cggatgcccc gtggccaggt caagtcagag     3360

cacctggaca ggtgtcctcc ctgctgctga ccctgcagag ggaaggggtg gggatgcagg     3420

accccgctct gcgggagccc catagccacc tctcttgccc aaggtgagcc agccctgggg     3480

acccagctca gggaggctct gctcagagtt cggcggaccc accccaaccc aactcccagc     3540

cgccagccaa agccactggg tgagcagagt cacccacagg gccagcccct cagccaggag     3600

ccagtggcag gagcggaaca gcccatccag cagagtgagt ccatccttcc caggttctcc     3660

cctgggagac tccctttgcc accaaggccc ccaccagggc ctctgaccac cgctctggag     3720

aggacagtgt ggcatgctcc aaggatcatc ttacttaact cgcagcctgt ggctgtggtc     3780

ctcttataga tactttcacc gtttgcaggg ttgctaatca gatacctgct gtcaccacac     3840

ttgggtcagg aaccctaatg agaacgggga gctgccaggg tgagggcagc cctcagggtc     3900

ggccgctttc cctctggacc acctcccgct gcgtttccta ctcagagaaa cagcaagggc     3960

ggggtcaaga cacgggatga cgggaagcag gaagcggggc agcagcacag cgtggggtcc     4020

tggcactgca ggccaggcca ggatgcccac cccgccctct acacggcccc ttggggcctg     4080

cgcccgtgaa actggtgcca gggagcactg ccagcttgcc agtttctgcc cagcaaaagc     4140

acgtatgctt caggggcctt ctgagaccac cttccccact gagccccagc tgctgagaag     4200

gccttgaggg aagtagaggc tgggagcaaa tgccccatgc ggtgagagga tgaggggagc     4260

ctacgcctca ggcatgtggt gagaggatga gggggaggga gcccacgcct caggtggagt     4320

gggcagaggt gcaagagagg gatgtactga agcttcttcc cgtcctgcca cagacacttc     4380

tcctgccttc ccaccctgac ccggcagaac ccaccaagtg cctgtgtgca gcctcctgtg     4440

cctcacccag ggcctgaccc cagagtggtc ccaacaaccc ggtctcatgc ccactcccca     4500

tccctgcttc ccaaaaattg cactgtgtgc agtttgcaac aaagaatccc gctggcatcc     4560

tgtccttggg aaccctttct cattctccaa gcctggtcag ctgcctgcac aggcagaggt     4620

gccctcagcc caggttagca acactcatag ttttgccaat taccagtaga cactagtgga     4680

accatctaac tggaacttcc tctctccttc cacttatttc ctcaaacttg ttgctttaca     4740

ctagacacat gcaaatgtat gttttaaaca caccaaaaca gatcatgcca aatgagttgc     4800

ctgtcaaagg ctggagggca ggaggagggc ctgggtttgg gttctttcct cccagccttt     4860

ggatggtgcc ttgggcccct tagccccagc gccagggcct cccagctgag gccacaggac     4920

aagcactttt ttatgatgta ctaaaagcca cagtatgtgg caactgcaaa aggatcagga     4980

atttagggta tgatctcggt cacgtgtccc gggcgctgag gggaaaggaa gcgggcatga     5040

ttgtagacaa tgagggggtt ctcttgatgt aatgaaatgc aattttatgg tttggtgcaa     5100

aaactcctat tttccagtaa attaacttta tttctaaagc atattttgat ttgccatcaa     5160

gagcaataaa gcattaaatc tt                                              5182


<210>  374
<211>  1006
<212>  PRT
<213>  Homo Sapiens

<400>  374

Met Ala Glu Gln Glu Ser Leu Glu Phe Gly Lys Ala Asp Phe Val Leu 
1               5                   10                  15      


Met Asp Thr Val Ser Met Pro Glu Phe Met Ala Asn Leu Arg Leu Arg 
            20                  25                  30          


Phe Glu Lys Gly Arg Ile Tyr Thr Phe Ile Gly Glu Val Val Val Ser 
        35                  40                  45              


Val Asn Pro Tyr Lys Leu Leu Asn Ile Tyr Gly Arg Asp Thr Ile Glu 
    50                  55                  60                  


Gln Tyr Lys Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Phe Ala 
65                  70                  75                  80  


Ile Ala Asp Ala Ala Tyr Lys Ala Met Lys Arg Arg Ser Lys Asp Thr 
                85                  90                  95      


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110         


Lys Tyr Ile Met Gln Tyr Ile Ala Ala Ile Thr Asn Pro Ser Gln Arg 
        115                 120                 125             


Ala Glu Val Glu Arg Val Lys Asn Met Leu Leu Lys Ser Asn Cys Val 
    130                 135                 140                 


Leu Glu Ala Phe Gly Asn Ala Lys Thr Asn Arg Asn Asp Asn Ser Ser 
145                 150                 155                 160 


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175     


Ile Gly Gly His Ile Asn Asn Tyr Leu Leu Glu Lys Ser Arg Val Ile 
            180                 185                 190         


Val Gln Gln Pro Gly Glu Arg Ser Phe His Ser Phe Tyr Gln Leu Leu 
        195                 200                 205             


Gln Gly Gly Ser Glu Gln Met Leu Arg Ser Leu His Leu Gln Lys Ser 
    210                 215                 220                 


Leu Ser Ser Tyr Asn Tyr Ile His Val Gly Ala Gln Leu Lys Ser Ser 
225                 230                 235                 240 


Ile Asn Asp Ala Ala Glu Phe Arg Val Val Ala Asp Ala Met Lys Val 
                245                 250                 255     


Ile Gly Phe Lys Pro Glu Glu Ile Gln Thr Val Tyr Lys Ile Leu Ala 
            260                 265                 270         


Ala Ile Leu His Leu Gly Asn Leu Lys Phe Val Val Asp Gly Asp Thr 
        275                 280                 285             


Pro Leu Ile Glu Asn Gly Lys Val Val Ser Ile Ile Ala Glu Leu Leu 
    290                 295                 300                 


Ser Thr Lys Thr Asp Met Val Glu Lys Ala Leu Leu Tyr Arg Thr Val 
305                 310                 315                 320 


Ala Thr Gly Arg Asp Ile Ile Asp Lys Gln His Thr Glu Gln Glu Ala 
                325                 330                 335     


Ser Tyr Gly Arg Asp Ala Phe Ala Lys Ala Ile Tyr Glu Arg Leu Phe 
            340                 345                 350         


Cys Trp Ile Val Thr Arg Ile Asn Asp Ile Ile Glu Val Lys Asn Tyr 
        355                 360                 365             


Asp Thr Thr Ile His Gly Lys Asn Thr Val Ile Gly Val Leu Asp Ile 
    370                 375                 380                 


Tyr Gly Phe Glu Ile Phe Asp Asn Asn Ser Phe Glu Gln Phe Cys Ile 
385                 390                 395                 400 


Asn Tyr Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Val Leu 
                405                 410                 415     


Lys Gln Glu Gln Glu Glu Tyr Gln Arg Glu Gly Ile Pro Trp Lys His 
            420                 425                 430         


Ile Asp Tyr Phe Asn Asn Gln Ile Ile Val Asp Leu Val Glu Gln Gln 
        435                 440                 445             


His Lys Gly Ile Ile Ala Ile Leu Asp Asp Ala Cys Met Asn Val Gly 
    450                 455                 460                 


Lys Val Thr Asp Glu Met Phe Leu Glu Ala Leu Asn Ser Lys Leu Gly 
465                 470                 475                 480 


Lys His Ala His Phe Ser Ser Arg Lys Leu Cys Ala Ser Asp Lys Ile 
                485                 490                 495     


Leu Glu Phe Asp Arg Asp Phe Arg Ile Arg His Tyr Ala Gly Asp Val 
            500                 505                 510         


Val Tyr Ser Val Ile Gly Phe Ile Asp Lys Asn Lys Asp Thr Leu Phe 
        515                 520                 525             


Gln Asp Phe Lys Arg Leu Met Tyr Asn Ser Ser Asn Pro Val Leu Lys 
    530                 535                 540                 


Asn Met Trp Pro Glu Gly Lys Leu Ser Ile Thr Glu Val Thr Lys Arg 
545                 550                 555                 560 


Pro Leu Thr Ala Ala Thr Leu Phe Lys Asn Ser Met Ile Ala Leu Val 
                565                 570                 575     


Asp Asn Leu Ala Ser Lys Glu Pro Tyr Tyr Val Arg Cys Ile Lys Pro 
            580                 585                 590         


Asn Asp Lys Lys Ser Pro Gln Ile Phe Asp Asp Glu Arg Cys Arg His 
        595                 600                 605             


Gln Val Glu Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala 
    610                 615                 620                 


Gly Phe Ala Phe Arg Gln Thr Tyr Glu Lys Phe Leu His Arg Tyr Lys 
625                 630                 635                 640 


Met Ile Ser Glu Phe Thr Trp Pro Asn His Asp Leu Pro Ser Asp Lys 
                645                 650                 655     


Glu Ala Val Lys Lys Leu Ile Glu Arg Cys Gly Phe Gln Asp Asp Val 
            660                 665                 670         


Ala Tyr Gly Lys Thr Lys Ile Phe Ile Arg Thr Pro Arg Thr Leu Phe 
        675                 680                 685             


Thr Leu Glu Glu Leu Arg Ala Gln Met Leu Ile Arg Ile Val Leu Phe 
    690                 695                 700                 


Leu Gln Lys Val Trp Arg Gly Thr Leu Ala Arg Met Arg Tyr Lys Arg 
705                 710                 715                 720 


Thr Lys Ala Ala Leu Thr Ile Ile Arg Tyr Tyr Arg Arg Tyr Lys Val 
                725                 730                 735     


Lys Ser Tyr Ile His Glu Val Ala Arg Arg Phe His Gly Val Lys Thr 
            740                 745                 750         


Met Arg Asp Tyr Gly Lys His Val Lys Trp Pro Ser Pro Pro Lys Val 
        755                 760                 765             


Leu Arg Arg Phe Glu Glu Ala Leu Gln Thr Ile Phe Asn Arg Trp Arg 
    770                 775                 780                 


Ala Ser Gln Leu Ile Lys Ser Ile Pro Ala Ser Asp Leu Pro Gln Val 
785                 790                 795                 800 


Arg Ala Lys Val Ala Ala Val Glu Met Leu Lys Gly Gln Arg Ala Asp 
                805                 810                 815     


Leu Gly Leu Gln Arg Ala Trp Glu Gly Asn Tyr Leu Ala Ser Lys Pro 
            820                 825                 830         


Asp Thr Pro Gln Thr Ser Gly Thr Phe Val Pro Val Ala Asn Glu Leu 
        835                 840                 845             


Lys Arg Lys Asp Lys Tyr Met Asn Val Leu Phe Ser Cys His Val Arg 
    850                 855                 860                 


Lys Val Asn Arg Phe Ser Lys Val Glu Asp Arg Ala Ile Phe Val Thr 
865                 870                 875                 880 


Asp Arg His Leu Tyr Lys Met Asp Pro Thr Lys Gln Tyr Lys Val Met 
                885                 890                 895     


Lys Thr Ile Pro Leu Tyr Asn Leu Thr Gly Leu Ser Val Ser Asn Gly 
            900                 905                 910         


Lys Asp Gln Leu Val Val Phe His Thr Lys Asp Asn Lys Asp Leu Ile 
        915                 920                 925             


Val Cys Leu Phe Ser Lys Gln Pro Thr His Glu Ser Arg Ile Gly Glu 
    930                 935                 940                 


Leu Val Gly Val Leu Val Asn His Phe Lys Ser Glu Lys Arg His Leu 
945                 950                 955                 960 


Gln Val Asn Val Thr Asn Pro Val Gln Cys Ser Leu His Gly Lys Lys 
                965                 970                 975     


Cys Thr Val Ser Val Glu Thr Arg Leu Asn Gln Pro Gln Pro Asp Phe 
            980                 985                 990         


Thr Lys Asn Arg Ser Gly Phe Ile  Leu Ser Val Pro Gly  Asn 
        995                 1000                 1005     


<210>  375
<211>  1545
<212>  DNA
<213>  Homo Sapiens

<400>  375
tttccgcgag cgccggcact gcccgctccg agcccgtgtc tgtcgggtgc cgagccaact       60

ttcctgcgtc catgcagccc cgccggcaac ggctgcctgc tccctggtcc gggcccaggg      120

gcccgcgccc caccgccccg ctgctcgcgc tgctgctgtt gctcgccccg gtggcggcgc      180

ccgcggggtc cggggacccc gacgaccctg ggcagcctca ggatgctggg gtcccgcgca      240

ggctcctgca gcaggcggcg cgcgcggcgc ttcacttctt caacttccgg tccggctcgc      300

ccagcgcgct acgagtgctg gccgaggtgc aggagggccg cgcgtggatt aatccaaaag      360

agggatgtaa agttcacgtg gtcttcagca cagagcgcta caacccagag tctttacttc      420

aggaaggtga gggacgtttg gggaaatgtt ctgctcgagt gtttttcaag aatcagaaac      480

ccagaccaac catcaatgta acttgtacac ggctcatcga gaaaaagaaa agacaacaag      540

aggattacct gctttacaag caaatgaagc aactgaaaaa ccccttggaa atagtcagca      600

tacctgataa tcatggacat attgatccct ctctgagact catctgggat ttggctttcc      660

ttggaagctc ttacgtgatg tgggaaatga caacacaggt gtcacactac tacttggcac      720

agctcactag tgtgaggcag tggaaaacta atgatgatac aattgatttt gattatactg      780

ttctacttca tgaattatca acacaggaaa taattccctg tcgcattcac ttggtctggt      840

accctggcaa acctcttaaa gtgaagtacc actgtcaaga gctacagaca ccagaagaag      900

cctccggaac tgaagaagga tcagctgtag taccaacaga gcttagtaat ttctaaaaag      960

aaaaaatgat ctttttccga cttctaaaca agtgactata ctagcataaa tcattcttct     1020

agtaaaacag ctaaggtata gacattctaa taatttggga aaacctatga ttacaagtaa     1080

aaactcagaa atgcaaagat gttggttttt tgtttctcag tctgctttag cttttaactc     1140

tggaagcgca tgcacactga actctgctca gtgctaaaca gtcaccagca ggttcctcag     1200

ggtttcagcc ctaaaatgta aaacctggat aatcagtgta tgttgcacca gaatcagcat     1260

ttttttttta actgcaaaaa atgatggtct catctctgaa tttatatttc tcattctttt     1320

gaacatacta tagctaatat attttatgtt gctaaattgc ttctatctag catgttaaac     1380

aaagataata tactttcgat gaaagtaaat tataggaaaa aaattaactg ttttaaaaag     1440

aacttgatta tgttttatga tttcaggcaa gtattcattt ttaacttgct acctactttt     1500

aaataaatgt ttacatttct aaataaaaaa aaaaaaaaaa aaaaa                     1545


<210>  376
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  376

Met Gln Pro Arg Arg Gln Arg Leu Pro Ala Pro Trp Ser Gly Pro Arg 
1               5                   10                  15      


Gly Pro Arg Pro Thr Ala Pro Leu Leu Ala Leu Leu Leu Leu Leu Ala 
            20                  25                  30          


Pro Val Ala Ala Pro Ala Gly Ser Gly Asp Pro Asp Asp Pro Gly Gln 
        35                  40                  45              


Pro Gln Asp Ala Gly Val Pro Arg Arg Leu Leu Gln Gln Ala Ala Arg 
    50                  55                  60                  


Ala Ala Leu His Phe Phe Asn Phe Arg Ser Gly Ser Pro Ser Ala Leu 
65                  70                  75                  80  


Arg Val Leu Ala Glu Val Gln Glu Gly Arg Ala Trp Ile Asn Pro Lys 
                85                  90                  95      


Glu Gly Cys Lys Val His Val Val Phe Ser Thr Glu Arg Tyr Asn Pro 
            100                 105                 110         


Glu Ser Leu Leu Gln Glu Gly Glu Gly Arg Leu Gly Lys Cys Ser Ala 
        115                 120                 125             


Arg Val Phe Phe Lys Asn Gln Lys Pro Arg Pro Thr Ile Asn Val Thr 
    130                 135                 140                 


Cys Thr Arg Leu Ile Glu Lys Lys Lys Arg Gln Gln Glu Asp Tyr Leu 
145                 150                 155                 160 


Leu Tyr Lys Gln Met Lys Gln Leu Lys Asn Pro Leu Glu Ile Val Ser 
                165                 170                 175     


Ile Pro Asp Asn His Gly His Ile Asp Pro Ser Leu Arg Leu Ile Trp 
            180                 185                 190         


Asp Leu Ala Phe Leu Gly Ser Ser Tyr Val Met Trp Glu Met Thr Thr 
        195                 200                 205             


Gln Val Ser His Tyr Tyr Leu Ala Gln Leu Thr Ser Val Arg Gln Trp 
    210                 215                 220                 


Lys Thr Asn Asp Asp Thr Ile Asp Phe Asp Tyr Thr Val Leu Leu His 
225                 230                 235                 240 


Glu Leu Ser Thr Gln Glu Ile Ile Pro Cys Arg Ile His Leu Val Trp 
                245                 250                 255     


Tyr Pro Gly Lys Pro Leu Lys Val Lys Tyr His Cys Gln Glu Leu Gln 
            260                 265                 270         


Thr Pro Glu Glu Ala Ser Gly Thr Glu Glu Gly Ser Ala Val Val Pro 
        275                 280                 285             


Thr Glu Leu Ser Asn Phe 
    290                 


<210>  377
<211>  2518
<212>  DNA
<213>  Homo Sapiens

<400>  377
ctcatttgtg tgttttctga gtcagcatta gctaaatttt ccagaaggcc atccacaaag       60

tacagcctgg gcgttcaagg gacgtcattc atttccccca gtgaccttga caagtcagaa      120

gcttgaaagc agggaaatcc ggatgtctcg gttatgaagt ggagcagtga gtgtgagcct      180

caacatagtt ccagaactct ccatccggac tagttattga gcatctgcct ctcatatcac      240

cagtggccat ctgaggtgtt tccctggctc tgaaggggta ggcacgatgg ccaggtgctt      300

cagcctggtg ttgcttctca cttccatctg gaccacgagg ctcctggtcc aaggctcttt      360

gcgtgcagaa gagctttcca tccaggtgtc atgcagaatt atggggatca cccttgtgag      420

caaaaaggcg aaccagcagc tgaatttcac agaagctaag gaggcctgta ggctgctggg      480

actaagtttg gccggcaagg accaagttga aacagccttg aaagctagct ttgaaacttg      540

cagctatggc tgggttggag atggattcgt ggtcatctct aggattagcc caaaccccaa      600

gtgtgggaaa aatggggtgg gtgtcctgat ttggaaggtt ccagtgagcc gacagtttgc      660

agcctattgt tacaactcat ctgatacttg gactaactcg tgcattccag aaattatcac      720

caccaaagat cccatattca acactcaaac tgcaacacaa acaacagaat ttattgtcag      780

tgacagtacc tactcggtgg catcccctta ctctacaata cctgccccta ctactactcc      840

tcctgctcca gcttccactt ctattccacg gagaaaaaaa ttgatttgtg tcacagaagt      900

ttttatggaa actagcacca tgtctacaga aactgaacca tttgttgaaa ataaagcagc      960

attcaagaat gaagctgctg ggtttggagg tgtccccacg gctctgctag tgcttgctct     1020

cctcttcttt ggtgctgcag ctggtcttgg attttgctat gtcaaaaggt atgtgaaggc     1080

cttccctttt acaaacaaga atcagcagaa ggaaatgatc gaaaccaaag tagtaaagga     1140

ggagaaggcc aatgatagca accctaatga ggaatcaaag aaaactgata aaaacccaga     1200

agagtccaag agtccaagca aaactaccgt gcgatgcctg gaagctgaag tttagatgag     1260

acagaaatga ggagacacac ctgaggctgg tttctttcat gctccttacc ctgccccagc     1320

tggggaaatc aaaagggcca aagaaccaaa gaagaaagtc cacccttggt tcctaactgg     1380

aatcagctca ggactgccat tggactatgg agtgcaccaa agagaatgcc cttctcctta     1440

ttgtaaccct gtctggatcc tatcctccta cctccaaagc ttcccacggc ctttctagcc     1500

tggctatgtc ctaataatat cccactggga gaaaggagtt ttgcaaagtg caaggaccta     1560

aaacatctca tcagtatcca gtggtaaaaa ggcctcctgg ctgtctgagg ctaggtgggt     1620

tgaaagccaa ggagtcactg agaccaaggc tttctctact gattccgcag ctcagaccct     1680

ttcttcagct ctgaaagaga aacacgtatc ccacctgaca tgtccttctg agcccggtaa     1740

gagcaaaaga atggcagaaa agtttagccc ctgaaagcca tggagattct cataacttga     1800

gacctaatct ctgtaaagct aaaataaaga aatagaacaa ggctgaggat acgacagtac     1860

actgtcagca gggactgtaa acacagacag ggtcaaagtg ttttctctga acacattgag     1920

ttggaatcac tgtttagaac acacacactt actttttctg gtctctacca ctgctgatat     1980

tttctctagg aaatatactt ttacaagtaa caaaaataaa aactcttata aatttctatt     2040

tttatctgag ttacagaaat gattactaag gaagattact cagtaatttg tttaaaaagt     2100

aataaaattc aacaaacatt tgctgaatag ctactatatg tcaagtgctg tgcaaggtat     2160

tacactctgt aattgaatat tattcctcaa aaaattgcac atagtagaac gctatctggg     2220

aagctatttt tttcagtttt gatatttcta gcttatctac ttccaaacta atttttattt     2280

ttgctgagac taatcttatt cattttctct aatatggcaa ccattataac cttaatttat     2340

tattaacata cctaagaagt acattgttac ctctatatac caaagcacat tttaaaagtg     2400

ccattaacaa atgtatcact agccctcctt tttccaacaa gaagggactg agagatgcag     2460

aaatatttgt gacaaaaaat taaagcattt agaaaacttc aaaaaaaaaa aaaaaaaa       2518


<210>  378
<211>  322
<212>  PRT
<213>  Homo Sapiens

<400>  378

Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr 
1               5                   10                  15      


Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile 
            20                  25                  30          


Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala 
        35                  40                  45              


Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu 
    50                  55                  60                  


Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala 
65                  70                  75                  80  


Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val 
                85                  90                  95      


Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly 
            100                 105                 110         


Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys 
        115                 120                 125             


Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile 
    130                 135                 140                 


Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr 
145                 150                 155                 160 


Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser 
                165                 170                 175     


Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser 
            180                 185                 190         


Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu 
        195                 200                 205             


Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala 
    210                 215                 220                 


Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu 
225                 230                 235                 240 


Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe 
                245                 250                 255     


Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn 
            260                 265                 270         


Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala 
        275                 280                 285             


Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro 
    290                 295                 300                 


Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala 
305                 310                 315                 320 


Glu Val 
        


<210>  379
<211>  1258
<212>  DNA
<213>  Homo Sapiens

<400>  379
caccattagg caaagatagt ttctctagag agaatcatgc ctgctaatta cacgtgtacc       60

aggccagatg gagacaatac agattttcga tactttattt atgcagtgac atacactgtc      120

attcttgtgc caggtctcat agggaatata ttagccctgt gggtattcta tggttatatg      180

aaagaaacaa aacgagctgt gatatttatg ataaacttag ccattgctga cttactacaa      240

gttctttcct tgccactgag gatcttctac tacttgaatc atgactggcc atttgggcct      300

ggtctctgca tgttctgttt ctacctgaag tatgtcaaca tgtatgcaag catctacttc      360

ttggtctgca tcagtgtgcg acgattttgg tttctcatgt acccctttcg cttccatgac      420

tgcaaacaga aatatgacct gtacatcagc attgctggct ggctgatcat ctgccttgcc      480

tgtgtactct ttccactcct cagaaccagt gatgatacct ctggcaatag gaccaaatgc      540

tttgtggatc ttcctaccag gaatgtcaac ctggcccagt ccgttgttat gatgaccatt      600

ggcgagttga ttgggtttgt aactccgctt ctgattgtcc tatattgtac ctggaagacg      660

gttttatcac tgcaagataa atatcccatg gcccaagatc ttggagagaa acagaaagcc      720

ttgaagatga ttctaacctg tgcaggggta ttcctaattt gctttgcacc ttatcatttc      780

agttttcctt tagatttcct ggtgaagtcc aatgaaatta aaagctgcct agccagaagg      840

gtgattctaa tatttcattc tgtggcattg tgtcttgcta gtctgaattc atgtcttgac      900

ccagtcatat actacttttc cactaatgag ttccgaagac ggctttcaag acaagatttg      960

catgacagca tccaactcca tgcaaaatcc tttgtgagta accatacagc ttccaccatg     1020

acacctgaat tatgctaaaa caaaaaacca aactgaatgt gacctgaaat gcaagtacat     1080

cagaacatat ctgcaatacc caagccacag ggaagaactt gcaaaacaac acagcttttc     1140

agttctgctc tatcttactg ctatggggaa ttcacttctt caaagcagga cctatttgga     1200

gcattacgat ccacgattat tgatgttgac atgtccatgt agtaattttt cttcaagt       1258


<210>  380
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  380

Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp 
1               5                   10                  15      


Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 
            20                  25                  30          


Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 
        35                  40                  45              


Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala 
    50                  55                  60                  


Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 
65                  70                  75                  80  


Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 
                85                  90                  95      


Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 
            100                 105                 110         


Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp 
        115                 120                 125             


Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile 
    130                 135                 140                 


Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp 
145                 150                 155                 160 


Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn 
                165                 170                 175     


Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile 
            180                 185                 190         


Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr 
        195                 200                 205             


Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu 
    210                 215                 220                 


Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 
225                 230                 235                 240 


Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 
                245                 250                 255     


Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 
            260                 265                 270         


Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 
        275                 280                 285             


Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser 
    290                 295                 300                 


Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val 
305                 310                 315                 320 


Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys 
                325                 330             


<210>  381
<211>  2031
<212>  DNA
<213>  Homo Sapiens

<400>  381
gccgcccggt tgcgcggacc ggcgctagtg cgcgggtggg ggcggcgcgc cgcggtggcc       60

cggcgtcccg tgtgcgtcca gtgtgcgccc cgcgggggcg cggccagcgc cagagtagat      120

acctgtcccg cccgccgcgg ccagcagcct cggaggaagc cagggcaaag agggccggcg      180

gagaccaggt ccgcgccgga ggaagccgcg cccggccgag gccccggacc ctgcgccccg      240

agctccacgg caccatggcc ccgaagctgc tgctcctcct ctgcctgttc tcgggcttgc      300

acgcgcggtc cagaaaggtg gaagaggatg aatatgaaga ttcatcatca aaccaaaagt      360

gggtcttggc tccaaaatcc caagacaccg acgtgactct tattctcaac aagttgctaa      420

gagaatatga taaaaagctg aggccagata ttggaataaa accgaccgta attgacgttg      480

acatttatgt taacagcatt ggtcctgtgt catcaataaa catggaatac caaattgaca      540

tattttttgc tcagacctgg acagatagtc gccttcgatt caacagcaca atgaaaattc      600

ttactctgaa cagcaacatg gtggggttaa tctggatccc agacaccatc ttccgcaatt      660

ctaaaaccgc agaggctcac tggatcacca cacccaatca gctcctccgg atttggaatg      720

acgggaaaat cctttacact ttgaggctca ccatcaatgc tgagtgccag ctgcagctgc      780

acaacttccc catggacgaa cactcctgcc cgctgatttt ctccagctat ggctatccca      840

aagaagaaat gatttataga tggagaaaaa attcagtgga ggcagctgac cagaaatcat      900

ggcggcttta tcagtttgac ttcatgggcc tcagaaacac cacagaaatc gtgacaacgt      960

ctgcaggtga ttatgttgtc atgactatat attttgaatt gagtagaaga atgggatact     1020

tcaccattca gacatacatt ccctgtatac tgactgtggt tttatcctgg gtgtcatttt     1080

ggatcaaaaa agatgctacg ccagcaagaa cagcattagg catcaccacg gtgctgacca     1140

tgaccaccct gagcaccatc gccaggaagt ccttgccacg cgtgtcctac gtgaccgcca     1200

tggacctttt tgtgaccgtg tgcttcctgt ttgtcttcgc cgcgctgatg gagtatgcca     1260

ccctcaacta ctattccagc tgtagaaaac caaccaccac gaagaagaca acatcgttac     1320

tacatccaga ttcctcaaga tggattcctg agcgaataag cctacaagcc ccttccaact     1380

attccctcct ggacatgagg ccaccaccaa ctgcgatgat cactttaaac aattccgttt     1440

actggcagga atttgaagat acctgtgtct atgagtgtct ggatggcaaa gactgtcaga     1500

gcttcttctg ctgctatgaa gaatgtaaat caggatcctg gaggaaaggg cgtattcaca     1560

tagacatctt ggagctggac tcgtactccc gggtcttttt ccccacgtcc ttcctgctct     1620

ttaacctggt ctactgggtt ggatacctgt atctctaagt gttgctcaga gtgaagagtg     1680

aagagcattt ggtacacact tgaccttctg tcgtccccag accagtagtg accaatcggg     1740

agtagcaagg aaggacactg cccagtgtat cttgttataa atgacctttc agcaacacag     1800

gaagtaccca gcaaaggttt ctattatgta ttttacacac acacatacat acacacacac     1860

agctaattga gttttaaagt aatattcttg ctaatcccta ctgaattgta gcttggtgtt     1920

gtttctgaat ggtttttgga tattggaagc agccgctgat tacccttgca aagaaatctg     1980

taaaatgtgc acgtgaatgt ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa a              2031


<210>  382
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  382

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Asp Tyr 
225                 230                 235                 240 


Val Val Met Thr Ile Tyr Phe Glu Leu Ser Arg Arg Met Gly Tyr Phe 
                245                 250                 255     


Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Lys Lys Asp Ala Thr Pro Ala Arg Thr Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala Arg 
    290                 295                 300                 


Lys Ser Leu Pro Arg Val Ser Tyr Val Thr Ala Met Asp Leu Phe Val 
305                 310                 315                 320 


Thr Val Cys Phe Leu Phe Val Phe Ala Ala Leu Met Glu Tyr Ala Thr 
                325                 330                 335     


Leu Asn Tyr Tyr Ser Ser Cys Arg Lys Pro Thr Thr Thr Lys Lys Thr 
            340                 345                 350         


Thr Ser Leu Leu His Pro Asp Ser Ser Arg Trp Ile Pro Glu Arg Ile 
        355                 360                 365             


Ser Leu Gln Ala Pro Ser Asn Tyr Ser Leu Leu Asp Met Arg Pro Pro 
    370                 375                 380                 


Pro Thr Ala Met Ile Thr Leu Asn Asn Ser Val Tyr Trp Gln Glu Phe 
385                 390                 395                 400 


Glu Asp Thr Cys Val Tyr Glu Cys Leu Asp Gly Lys Asp Cys Gln Ser 
                405                 410                 415     


Phe Phe Cys Cys Tyr Glu Glu Cys Lys Ser Gly Ser Trp Arg Lys Gly 
            420                 425                 430         


Arg Ile His Ile Asp Ile Leu Glu Leu Asp Ser Tyr Ser Arg Val Phe 
        435                 440                 445             


Phe Pro Thr Ser Phe Leu Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  383
<211>  1145
<212>  DNA
<213>  Homo Sapiens

<400>  383
atttcactca gtgcttacca gagcgcgttg tctaccctgt accgaagaca gaggctgtgg       60

ggacagccta ggggcctgga tctattgcct acttagagag aggccaactc agacacagcc      120

gtgtatgctc ccagcagcaa cggaggttca gctccgcctg cagggacaga aagacatggt      180

ctggaaatgg atgccacttc tgctgcttct ggtctgtgta gccaccatgt gcagtgccca      240

ggacaggact gatctcctca atgtctgtat ggatgccaag caccacaaga caaagccagg      300

tcctgaggac aagctgcatg accaatgcag tccctggaag aagaatgcct gctgcacagc      360

cagcaccagc caggagctgc acaaggacac ctcccgcctg tacaacttta actgggacca      420

ctgcggcaag atggagcccg cctgcaagcg ccacttcatc caggacacct gtctctatga      480

gtgctcaccc aacctggggc cctggatcca gcaggtgaat cagagctggc gcaaagaacg      540

cttcctggat gtgcccttat gcaaagagga ctgtcagcgc tggtgggagg attgtcacac      600

ctcccacacg tgcaagagca actggcacag aggatgggac tggacctcag gagttaacaa      660

gtgcccagct ggggctctct gccgcacctt tgagtcctac ttccccactc cagctgccct      720

ttgtgaaggc ctctggagtc actcatacaa ggtcagcaac tacagccgag ggagcggccg      780

ctgcatccag atgtggtttg attcagccca gggcaacccc aacgaggaag tggcgaggtt      840

ctatgctgca gccatgcatg tgaatgctgg tgagatgctt catgggactg ggggtctcct      900

gctcagtctg gccctgatgc tgcaactctg gctccttggc tgagttcagt cctcccagac      960

tacctgccct cagcttggat aaccaggctg ggctcagctc agctcccaca aatgacagcc     1020

ccttaagcat gcttctatta gtcacctaac cctctgtcac ccagtctgtt gctgctccat     1080

ggtggggcca agagtcactt ctaataaaca gactgttttc taataattcc aaaaaaaaaa     1140

aaaaa                                                                 1145


<210>  384
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  384

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  385
<211>  1862
<212>  DNA
<213>  Homo Sapiens

<400>  385
ctgcaatggg gttgctactg ctgcggctaa ccaaacagct catgcttctc tgaagacttg       60

cagcaaggct tgctgaggct cacagaagat agccccagtg ttttggagtg gttttgaatg      120

tgattctgag atcagactga ctgagctgga atcctggctt tatatcttac cagctacaca      180

accttggagt cttagaaatt ttttcttttc aataagcagt catccttact ttccctcaag      240

atgacaaaca gttcgttctt ctgcccagtt tataaagatc tggagccatt cacgtatttt      300

ttttatttag ttttccttgt tggaattatt ggaagttgtt ttgcaacctg ggcttttata      360

cagaagaata cgaatcacag gtgtgtgagc atctacttaa ttaatttgct tacagccgat      420

ttcctgctta ctctggcatt accagtgaaa attgttgttg acttgggtgt ggcaccttgg      480

aagctgaaga tattccactg ccaagtaaca gcctgcctca tctatatcaa tatgtattta      540

tcaattatct tcttagcatt tgtcagcatt gaccgctgtc ttcagctgac acacagctgc      600

aagatctacc gaatacaaga acccggattt gccaaaatga tatcaaccgt tgtgtggcta      660

atggtccttc ttataatggt gccaaatatg atgattccca tcaaagacat caaggaaaag      720

tcaaatgtgg gttgtatgga gtttaaaaag gaatttggaa gaaattggca tttgctgaca      780

aatttcatat gtgtagcaat atttttaaat ttctcagcca tcattttaat atccaattgc      840

cttgtaattc gacagctcta cagaaacaaa gataatgaaa attacccaaa tgtgaaaaag      900

gctctcatca acatactttt agtgaccacg ggctacatca tatgctttgt tccttaccac      960

attgtccgaa tcccgtatac cctcagccag acagaagtca taactgattg ctcaaccagg     1020

atttcactct tcaaagccaa agaggctaca ctgctcctgg ctgtgtcgaa cctgtgcttt     1080

gatcctatcc tgtactatca cctctcaaaa gcattccgct caaaggtcac tgagactttt     1140

gcctcaccta aagagaccaa ggctcagaaa gaaaaattaa gatgtgaaaa taatgcataa     1200

aagacaggat tttttgtgct accaattctg gccttactgg accataaagt taattatagc     1260

tttgaaagat aaaaaaaaaa aaaacaaaaa aaaactcagt atgaaaaaat acagttagct     1320

agcaaatatg gacaggttta cttagaaatc ctgtttctaa atgcaagtca agctttattg     1380

ttaggcttgc tgctactcat taacccaaat atttgtacaa aaaactaaag agtctcattg     1440

aacgaatgta aaatcctgca atatccttga aatccaaaag aggtccatga catagaccca     1500

aaggtattca tgagttattc atttaaatgc ctggaactga cttcttgata aaaatataaa     1560

aaataatttc catgtaagtt accagaaagc ccaccagcaa cataatttta aagcctttca     1620

gattactttt aaaaaatgca gcttacatat aacaacttgt gcctatttta tttctaatct     1680

atcacttcaa aagatggtaa tctttcaact cattattcct ccaattttta atgtcgaatt     1740

tttttctaac acaataacca aaagctttta tttataaaaa ggcttgaaaa atataaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aa                                                                    1862


<210>  386
<211>  319
<212>  PRT
<213>  Homo Sapiens

<400>  386

Met Thr Asn Ser Ser Phe Phe Cys Pro Val Tyr Lys Asp Leu Glu Pro 
1               5                   10                  15      


Phe Thr Tyr Phe Phe Tyr Leu Val Phe Leu Val Gly Ile Ile Gly Ser 
            20                  25                  30          


Cys Phe Ala Thr Trp Ala Phe Ile Gln Lys Asn Thr Asn His Arg Cys 
        35                  40                  45              


Val Ser Ile Tyr Leu Ile Asn Leu Leu Thr Ala Asp Phe Leu Leu Thr 
    50                  55                  60                  


Leu Ala Leu Pro Val Lys Ile Val Val Asp Leu Gly Val Ala Pro Trp 
65                  70                  75                  80  


Lys Leu Lys Ile Phe His Cys Gln Val Thr Ala Cys Leu Ile Tyr Ile 
                85                  90                  95      


Asn Met Tyr Leu Ser Ile Ile Phe Leu Ala Phe Val Ser Ile Asp Arg 
            100                 105                 110         


Cys Leu Gln Leu Thr His Ser Cys Lys Ile Tyr Arg Ile Gln Glu Pro 
        115                 120                 125             


Gly Phe Ala Lys Met Ile Ser Thr Val Val Trp Leu Met Val Leu Leu 
    130                 135                 140                 


Ile Met Val Pro Asn Met Met Ile Pro Ile Lys Asp Ile Lys Glu Lys 
145                 150                 155                 160 


Ser Asn Val Gly Cys Met Glu Phe Lys Lys Glu Phe Gly Arg Asn Trp 
                165                 170                 175     


His Leu Leu Thr Asn Phe Ile Cys Val Ala Ile Phe Leu Asn Phe Ser 
            180                 185                 190         


Ala Ile Ile Leu Ile Ser Asn Cys Leu Val Ile Arg Gln Leu Tyr Arg 
        195                 200                 205             


Asn Lys Asp Asn Glu Asn Tyr Pro Asn Val Lys Lys Ala Leu Ile Asn 
    210                 215                 220                 


Ile Leu Leu Val Thr Thr Gly Tyr Ile Ile Cys Phe Val Pro Tyr His 
225                 230                 235                 240 


Ile Val Arg Ile Pro Tyr Thr Leu Ser Gln Thr Glu Val Ile Thr Asp 
                245                 250                 255     


Cys Ser Thr Arg Ile Ser Leu Phe Lys Ala Lys Glu Ala Thr Leu Leu 
            260                 265                 270         


Leu Ala Val Ser Asn Leu Cys Phe Asp Pro Ile Leu Tyr Tyr His Leu 
        275                 280                 285             


Ser Lys Ala Phe Arg Ser Lys Val Thr Glu Thr Phe Ala Ser Pro Lys 
    290                 295                 300                 


Glu Thr Lys Ala Gln Lys Glu Lys Leu Arg Cys Glu Asn Asn Ala 
305                 310                 315                 


<210>  387
<211>  1828
<212>  DNA
<213>  Homo Sapiens

<400>  387
cagttacagg gagcaccacc agggaacatc tcggggagcc tggttggaag ctgcaggctt       60

agtctgtcgg ctgcgggtct ctgactgccc tgtggggagg gtcttgcctt aacatccctt      120

gcatttggct gcaaagaaat ctgcttggaa gaaggggtta cgctgtttgg ccgggcagaa      180

actccgctga gcagaacttg ccgccagaat gctcctcctg ttgctgagta tcatcgtcct      240

ccacgtcgcg gtgctggtgc tgctgttcgt ctccacgatc gtcagccaat ggatcgtggg      300

caatggacac gcaactgatc tctggcagaa ctgtagcacc tcttcctcag gaaatgtcca      360

ccactgtttc tcatcatcac caaacgaatg gctgcagtct gtccaggcca ccatgatcct      420

gtcgatcatc ttcagcattc tgtctctgtt cctgttcttc tgccaactct tcaccctcac      480

caaggggggc aggttttaca tcactggaat cttccaaatt cttgctggtc tgtgcgtgat      540

gagtgctgcg gccatctaca cggtgaggca cccggagtgg catctcaact cggattactc      600

ctacggtttc gcctacatcc tggcctgggt ggccttcccc ctggcccttc tcagcggtgt      660

catctatgtg atcttgcgga aacgcgaatg aggcgcccag acggtctgtc tgaggctctg      720

agcgtacata gggaagggag gaagggaaaa cagaaagcag acaaagaaaa aagagctagc      780

ccaaaatccc aaactcaaac caaaccaaac agaaagcagt ggaggtgggg gttgctgttg      840

attgaagatg tatataatat ctccggttta taaaacctat ttataacact ttttacatat      900

atgtacatag tattgtttgc tttttatgtt gaccatcagc ctcgtgttga gccttaaaga      960

agtagctaag gaactttaca tcctaacagt ataatccagc tcagtatttt tgttttgttt     1020

tttgtttgtt tgttttgttt tacccagaaa taagataact ccatctcgcc ccttcccttt     1080

catctgaaag aagatacctc cctcccagtc cacctcattt agaaaaccaa agtgtgggta     1140

gaaaccccaa atgtccaaaa gcccttttct ggtgggtgac ccagtgcatc caacagaaac     1200

agccgctgcc cgaacctctg tgtgaagctt tacgcgcaca cggacaaaat gcccaaactg     1260

gagcccttgc aaaaacacgg cttgtggcat tggcatactt gcccttacag gtggagtatc     1320

ttcgtcacac atctaaatga gaaatcagtg acaacaagtc tttgaaatgg tgctatggat     1380

ttaccattcc ttattatcac taatcatcta aacaactcac tggaaatcca attaacaatt     1440

ttacaacata agatagaatg gagacctgaa taattctgtg taatataaat ggtttataac     1500

tgcttttgta cctagctagg ctgctattat tactataatg agtaaatcat aaagccttca     1560

tcactcccac atttttctta cggtcggagc atcagaacaa gcgtctagac tccttgggac     1620

cgtgagttcc tagagcttgg ctgggtctag gctgttctgt gcctccaagg actgtctggc     1680

aatgacttgt attggccacc aactgtagat gtatatatgg tgcccttctg atgctaagac     1740

tccagacctt ttgtttttgc tttgcatttt ctgattttat accaactgtg tggactaaga     1800

tgcattaaaa taaacatcag agtaactc                                        1828


<210>  388
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  388

Met Leu Leu Leu Leu Leu Ser Ile Ile Val Leu His Val Ala Val Leu 
1               5                   10                  15      


Val Leu Leu Phe Val Ser Thr Ile Val Ser Gln Trp Ile Val Gly Asn 
            20                  25                  30          


Gly His Ala Thr Asp Leu Trp Gln Asn Cys Ser Thr Ser Ser Ser Gly 
        35                  40                  45              


Asn Val His His Cys Phe Ser Ser Ser Pro Asn Glu Trp Leu Gln Ser 
    50                  55                  60                  


Val Gln Ala Thr Met Ile Leu Ser Ile Ile Phe Ser Ile Leu Ser Leu 
65                  70                  75                  80  


Phe Leu Phe Phe Cys Gln Leu Phe Thr Leu Thr Lys Gly Gly Arg Phe 
                85                  90                  95      


Tyr Ile Thr Gly Ile Phe Gln Ile Leu Ala Gly Leu Cys Val Met Ser 
            100                 105                 110         


Ala Ala Ala Ile Tyr Thr Val Arg His Pro Glu Trp His Leu Asn Ser 
        115                 120                 125             


Asp Tyr Ser Tyr Gly Phe Ala Tyr Ile Leu Ala Trp Val Ala Phe Pro 
    130                 135                 140                 


Leu Ala Leu Leu Ser Gly Val Ile Tyr Val Ile Leu Arg Lys Arg Glu 
145                 150                 155                 160 


<210>  389
<211>  2424
<212>  DNA
<213>  Homo Sapiens

<400>  389
gcatcctctc accgccggaa gctgaactga ctcgtccgcg gccgctctac cccaacaggc       60

cgccaccagc gagagtgcgg ccataaccat cacgtgaccg cccaccgaca ccagcgagag      120

tgcagtcgta accgtcacgt gaccgcccac cgtcggcccg gcgctcccct ccgcccgaag      180

ctagcaagcg gcgcggccaa tgagaaaggc gcatgcctgg cccccgccgg cctgcagtct      240

agccgtagtg cgcctgcgcg cggctaggag gggccgtcag gcggggatac agcctggaag      300

gtgcgtgtgg ggctgggtct cggagtggga gacgtggagt gcaggctgga gcgaccgtgt      360

ctggggagcc gagccccgct tctcgctgcg gtgagcccgg actggggcac gcactgcgca      420

gactccccgc tgcagtgggc ggagctccca caggccccgc cccctcctcc caccctcgtt      480

cagcctgtcc agacagaagc tggggcccac cggaggtagc tgcagacgcc tgagagcgag      540

gccgaggccc ctcagggttt ggagaccctg acacacccac cttctcacct gggctctgcg      600

tatcccccag ccttgaggga agatgaagcc taaactgatg taccaggagc tgaaggtgcc      660

tgcagaggag cccgccaatg agctgcccat gaatgagatt gaggcgtgga aggctgcgga      720

aaagaaagcc cgctgggtcc tgctggtcct cattctggcg gttgtgggct tcggagccct      780

gatgactcag ctgtttctat gggaatacgg cgacttgcat ctctttgggc ccaaccagcg      840

cccagccccc tgctatgacc cttgcgaagc agtgctggtg gaaagcattc ctgagggcct      900

ggacttcccc aatgcctcca cggggaaccc ttccaccagc caggcctggc tgggcctgct      960

cgccggtgcg cacagcagcc tggacatcgc ctccttctac tggaccctca ccaacaatga     1020

cacccacacg caggagccct ctgcccagca gggtgaggag gtcctccggc agctgcagac     1080

cctggcacca aagggcgtga acgtccgcat cgctgtgagc aagcccagcg ggccccagcc     1140

acaggcggac ctgcaggctc tgctgcagag cggtgcccag gtccgcatgg tggacatgca     1200

gaagctgacc catggcgtcc tgcataccaa gttctgggtg gtggaccaga cccacttcta     1260

cctgggcagt gccaacatgg actggcgttc actgacccag gtcaaggagc tgggcgtggt     1320

catgtacaac tgcagctgcc tggctcgaga cctgaccaag atctttgagg cctactggtt     1380

cctgggccag gcaggcagct ccatcccatc aacttggccc cggttctatg acacccgcta     1440

caaccaagag acaccaatgg agatctgcct caatggaacc cctgctctgg cctacctggc     1500

gagtgcgccc ccacccctgt gtccaagtgg ccgcactcca gacctgaagg ctctactcaa     1560

cgtggtggac aatgcccgga gtttcatcta cgtcgctgtc atgaactacc tgcccactct     1620

ggagttctcc caccctcaca ggttctggcc tgccattgac gatgggctgc ggcgggccac     1680

ctacgagcgt ggcgtcaagg tgcgcctgct catcagctgc tggggacact cggagccatc     1740

catgcgggcc ttcctgctct ctctggctgc cctgcgtgac aaccataccc actctgacat     1800

ccaggtgaaa ctctttgtgg tccccgcgga tgaggcccag gctcgaatcc catatgcccg     1860

tgtcaaccac aacaagtaca tggtgactga acgcgccacc tacatcggaa cctccaactg     1920

gtctggcaac tacttcacgg agacggcggg cacctcgctg ctggtgacgc agaatgggag     1980

gggcggcctg cggagccagc tggaggccat tttcctgagg gactgggact ccccttacag     2040

ccatgacctt gacacctcag ctgacagcgt gggcaacgcc tgccgcctgc tctgaggccc     2100

gatccagtgg gcaggccaag gcctgctggg cccccgcgga cccaggtgct ctgggtcacg     2160

gtccctgtcc ccgcgccccc gcttctgtct gccccattgt ggctcctcag gctctctccc     2220

ctgctctccc acctctacct ccacccccac cggcctgacg ctgtggcccc gggacccagc     2280

agagctgggg gagggatcag cccccaaaga aatgggggtg catgctgggc ctggccccct     2340

ggcccacccc cactttccag ggcaaaaagg gcccagggtt ataataagta aataacttgt     2400

ctgtaaaaaa aaaaaaaaaa aaaa                                            2424


<210>  390
<211>  490
<212>  PRT
<213>  Homo Sapiens

<400>  390

Met Lys Pro Lys Leu Met Tyr Gln Glu Leu Lys Val Pro Ala Glu Glu 
1               5                   10                  15      


Pro Ala Asn Glu Leu Pro Met Asn Glu Ile Glu Ala Trp Lys Ala Ala 
            20                  25                  30          


Glu Lys Lys Ala Arg Trp Val Leu Leu Val Leu Ile Leu Ala Val Val 
        35                  40                  45              


Gly Phe Gly Ala Leu Met Thr Gln Leu Phe Leu Trp Glu Tyr Gly Asp 
    50                  55                  60                  


Leu His Leu Phe Gly Pro Asn Gln Arg Pro Ala Pro Cys Tyr Asp Pro 
65                  70                  75                  80  


Cys Glu Ala Val Leu Val Glu Ser Ile Pro Glu Gly Leu Asp Phe Pro 
                85                  90                  95      


Asn Ala Ser Thr Gly Asn Pro Ser Thr Ser Gln Ala Trp Leu Gly Leu 
            100                 105                 110         


Leu Ala Gly Ala His Ser Ser Leu Asp Ile Ala Ser Phe Tyr Trp Thr 
        115                 120                 125             


Leu Thr Asn Asn Asp Thr His Thr Gln Glu Pro Ser Ala Gln Gln Gly 
    130                 135                 140                 


Glu Glu Val Leu Arg Gln Leu Gln Thr Leu Ala Pro Lys Gly Val Asn 
145                 150                 155                 160 


Val Arg Ile Ala Val Ser Lys Pro Ser Gly Pro Gln Pro Gln Ala Asp 
                165                 170                 175     


Leu Gln Ala Leu Leu Gln Ser Gly Ala Gln Val Arg Met Val Asp Met 
            180                 185                 190         


Gln Lys Leu Thr His Gly Val Leu His Thr Lys Phe Trp Val Val Asp 
        195                 200                 205             


Gln Thr His Phe Tyr Leu Gly Ser Ala Asn Met Asp Trp Arg Ser Leu 
    210                 215                 220                 


Thr Gln Val Lys Glu Leu Gly Val Val Met Tyr Asn Cys Ser Cys Leu 
225                 230                 235                 240 


Ala Arg Asp Leu Thr Lys Ile Phe Glu Ala Tyr Trp Phe Leu Gly Gln 
                245                 250                 255     


Ala Gly Ser Ser Ile Pro Ser Thr Trp Pro Arg Phe Tyr Asp Thr Arg 
            260                 265                 270         


Tyr Asn Gln Glu Thr Pro Met Glu Ile Cys Leu Asn Gly Thr Pro Ala 
        275                 280                 285             


Leu Ala Tyr Leu Ala Ser Ala Pro Pro Pro Leu Cys Pro Ser Gly Arg 
    290                 295                 300                 


Thr Pro Asp Leu Lys Ala Leu Leu Asn Val Val Asp Asn Ala Arg Ser 
305                 310                 315                 320 


Phe Ile Tyr Val Ala Val Met Asn Tyr Leu Pro Thr Leu Glu Phe Ser 
                325                 330                 335     


His Pro His Arg Phe Trp Pro Ala Ile Asp Asp Gly Leu Arg Arg Ala 
            340                 345                 350         


Thr Tyr Glu Arg Gly Val Lys Val Arg Leu Leu Ile Ser Cys Trp Gly 
        355                 360                 365             


His Ser Glu Pro Ser Met Arg Ala Phe Leu Leu Ser Leu Ala Ala Leu 
    370                 375                 380                 


Arg Asp Asn His Thr His Ser Asp Ile Gln Val Lys Leu Phe Val Val 
385                 390                 395                 400 


Pro Ala Asp Glu Ala Gln Ala Arg Ile Pro Tyr Ala Arg Val Asn His 
                405                 410                 415     


Asn Lys Tyr Met Val Thr Glu Arg Ala Thr Tyr Ile Gly Thr Ser Asn 
            420                 425                 430         


Trp Ser Gly Asn Tyr Phe Thr Glu Thr Ala Gly Thr Ser Leu Leu Val 
        435                 440                 445             


Thr Gln Asn Gly Arg Gly Gly Leu Arg Ser Gln Leu Glu Ala Ile Phe 
    450                 455                 460                 


Leu Arg Asp Trp Asp Ser Pro Tyr Ser His Asp Leu Asp Thr Ser Ala 
465                 470                 475                 480 


Asp Ser Val Gly Asn Ala Cys Arg Leu Leu 
                485                 490 


<210>  391
<211>  1869
<212>  DNA
<213>  Homo Sapiens

<400>  391
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc       60

caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct      120

ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta      180

tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa      240

tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt      300

acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca      360

gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct      420

ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca      480

gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaact      540

ctctgtctcc aagcccacag tgacaactgg cagcggttat ggcttcacgg tgccccaggg      600

aatgaggatt agccttcaat gccaggctcg gggttctcct cccatcagtt atatttggta      660

taagcaacag actaataacc aggaacccat caaagtagca accctaagta ccttactctt      720

caagcctgcg gtgatagccg actcaggctc ctatttctgc actgccaagg gccaggttgg      780

ctctgagcag cacagcgaca ttgtgaagtt tgtggtcaaa gactcctcaa agctactcaa      840

gaccaagact gaggcaccta caaccatgac ataccccttg aaagcaacat ctacagtgaa      900

gcagtcctgg gactggacca ctgacatgga tggctacctt ggagagacca gtgctgggcc      960

aggaaagagc ctgcctgtct ttgccatcat cctcatcatc tccttgtgct gtatggtggt     1020

ttttaccatg gcctatatca tgctctgtcg gaagacatcc caacaagagc atgtctacga     1080

agcagccagg gcacatgcca gagaggccaa cgactctgga gaaaccatga gggtggccat     1140

cttcgcaagt ggctgctcca gtgatgagcc aacttcccag aatctgggca acaactactc     1200

tgatgagccc tgcataggac aggagtacca gatcatcgcc cagatcaatg gcaactacgc     1260

ccgcctgctg gacacagttc ctctggatta tgagtttctg gccactgagg gcaaaagtgt     1320

ctgttaaaaa tgccccatta ggccaggatc tgctgacata attgcctagt cagtccttgc     1380

cttctgcatg gccttcttcc ctgctacctc tcttcctgga tagcccaaag tgtccgccta     1440

ccaacactgg agccgctggg agtcactggc tttgccctgg aatttgccag atgcatctca     1500

agtaagccag ctgctggatt tggctctggg cccttctagt atctctgccg ggggcttctg     1560

gtactcctct ctaaatacca gagggaagat gcccatagca ctaggacttg gtcatcatgc     1620

ctacagacac tattcaactt tggcatcttg ccaccagaag acccgaggga ggctcagctc     1680

tgccagctca gaggaccagc tatatccagg atcatttctc tttcttcagg gccagacagc     1740

ttttaattga aattgttatt tcacaggcca gggttcagtt ctgctcctcc actataagtc     1800

taatgttctg actctctcct ggtgctcaat aaatatctaa tcataacagc aaaaaaaaaa     1860

aaaaaaaaa                                                             1869


<210>  392
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  392

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210>  393
<211>  11332
<212>  DNA
<213>  Homo Sapiens

<400>  393
tttttttttt ccccaagcga agcatgaaca gttgctaagt ggaaaatgga ggctgaattt       60

tacatggtga ttcttacctg cttgatcttc aggaactcag aagggtttca gattgtccat      120

gtccagaaac aacagtgtct tttcaaaaat gagaaagtgg tcgtgggctc atgcaacagg      180

accatccaga accagcagtg gatgtggact gaggatgaaa agctccttca tgttaaatct      240

gcactgtgct tggccatctc caactcttcc cgcggcccct cccgctcagc catcttggac      300

cgctgttccc aggcaccccg atggacctgc tatgatcagg aaggcttcct tgaggtggaa      360

aatgcctctc tctttctcca gaaacaaggc tccagagtag tggtcaagaa ggccaggaaa      420

tacctccata gctggatgaa aatagatgtc aacaaggagg gaaaactggt caatgaaagc      480

ctctgtttac aaaaagctgg cctgggagca gaagtttcgg tgaggagcac tagaaacacg      540

gctccacccc agattctcac tacctttaat gcagttccag atggcctggt attccttatt      600

aggaatacca cagaggcctt catcagaaat gctgcagaaa actacagcca aaacagcagc      660

gagaggcagc atcccaatct gcacatgact ggaattacag acacatcatg ggttttgtcg      720

actactcagc ccttctccag caccactgaa gagactggac tggcggagcc agagagatgt      780

aacttcaccc tggcggagtc caaggcctcc agccattctg tgtctatcca gtggagaatt      840

ttgggctcac cctgtaactt tagcctcatc tatagcagtg acaccctggg ggccgcgttg      900

tgccctacct ttcggataga caacaccaca tacggatgta accttcaaga tttacaagca      960

ggaaccatct ataacttcag gattatttct ctggatgaag agagaacagt ggtcttgcaa     1020

acagatcctt tacctcctgc taggtttgga gtcagtaaag agaagacgac ttcaaccagc     1080

ttgcatgttt ggtggactcc ttcttccgga aaagtcacct catatgaggt gcaattattt     1140

gatgaaaata accaaaagat acagggggtt caaattcaag aaagtacttc atggaatgaa     1200

tacacttttt tcaatctcac tgctggtagt aaatacaata ttgccatcac agctgtttct     1260

ggaggaaaac gttctttttc agtttatacc aatggatcaa cagtgccatc tccagtgaaa     1320

gatattggta tttccacaaa agccaattct ctcctgattt cctggtccca tggttctggg     1380

aatgtggaac gataccggct gatgctaatg gataaaggga tcctagttca tggcggtgtt     1440

gtggacaaac atgctacttc ctatgctttt cacgggctga cccctggcta cctctacaac     1500

ctcactgtta tgactgaggc tgcagggctg caaaactaca ggtggaaact agtcaggaca     1560

gcccccatgg aagtctcaaa tctgaaggtg acaaatgatg gcagtttgac ctctctaaaa     1620

gtcaaatggc aaagacctcc tggaaatgtg gattcttaca atatcaccct gtctcacaaa     1680

gggaccatca aggaatccag agtattagca ccttggatta ctgaaactca ctttaaagag     1740

ttagtccccg gtcgacttta tcaagttact gtcagctgtg tctctggtga actgtctgct     1800

cagaagatgg cagtgggcag aacatttcca gacaaagttg caaacctgga ggcaaacaat     1860

aatggcagga tgaggtctct tgtagtgagc tggtcgcccc ctgctggaga ctgggagcag     1920

tatcggatcc tactcttcaa tgattctgtg gtgctgctca acatcactgt gggaaaggaa     1980

gaaacacagt atgtcatgga tgacacgggg ctcgtaccgg gaagacagta tgaggtggaa     2040

gtcattgttg agagtggaaa tttgaagaat tctgagcgtt gccaaggcag gacagtcccc     2100

ctggctgtcc tccagcttcg tgtcaaacat gccaatgaaa cctcactgag tatcatgtgg     2160

cagacccctg tagcagaatg ggagaaatac atcatttccc tagctgacag agacctctta     2220

ctgatccaca agtcactctc caaagatgcc aaagaattca cttttactga cctggtgcct     2280

ggacgaaaat acatggctac agtcaccagt attagtggag acttaaaaaa ttcctcttca     2340

gtaaaaggaa gaacagtgcc tgcccaagtg actgacttgc atgtggccaa ccaaggaatg     2400

accagtagtc tgtttactaa ctggacccag gcacaaggag acgtagaatt ttaccaagtc     2460

ttactgatcc atgaaaatgt ggtcattaaa aatgaaagca tctccagtga gaccagcaga     2520

tacagcttcc actctctcaa gtccggcagc ctgtactccg tggtggtaac aacagtgagt     2580

ggagggatct cttcccgaca agtggttgtg gagggaagaa cagtcccttc cagtgtgagt     2640

ggagtaacgg tgaacaattc cggtcgtaat gactacctca gcgtttcctg gctgctggcg     2700

cccggagatg tggataacta tgaggtaaca ttgtctcatg acggcaaggt ggttcagtcc     2760

cttgtcattg ccaagtctgt cagagaatgt tccttcagct ccctcacccc aggccgcctc     2820

tacaccgtga ccataactac aaggagtggc aagtatgaaa atcactcctt cagccaagag     2880

cggacagtgc ctgacaaagt ccagggagtc agtgttagca actcagccag gagtgactat     2940

ttaagggtat cctgggtgca tgccactgga gactttgatc actatgaagt caccattaaa     3000

aacaaaaaca acttcattca aactaaaagc attcccaagt cagaaaacga atgtgtattt     3060

gttcagctag tccctggacg gttgtacagt gtcactgtta ctacaaaaag tggacaatat     3120

gaagccaatg aacaagggaa tgggagaaca attccagagc ctgttaagga tctaacattg     3180

cgcaacagga gcactgagga cttgcatgtg acttggtcag gagctaatgg ggatgtcgac     3240

caatatgaga tccagctgct cttcaatgac atgaaagtat ttcctccttt tcaccttgta     3300

aataccgcaa ccgagtatcg atttacttcc ctaacaccag gccgccaata caaaattctt     3360

gtcttgacga ttagcgggga tgtacagcag tcagccttca ttgagggctt cacagttcct     3420

agtgctgtca aaaatattca catttctccc aatggagcaa cagatagcct gacggtgaac     3480

tggactcctg gtgggggaga cgttgattcc tacacggtgt cggcattcag gcacagtcaa     3540

aaggttgact ctcagactat tcccaagcac gtctttgagc acacgttcca cagactggag     3600

gccggggagc agtaccagat catgattgcc tcagtcagcg ggtccctgaa gaatcagata     3660

aatgtggttg ggcggacagt tccagcatct gtccaaggag taattgcaga caatgcatac     3720

agcagttatt ccttaatagt aagttggcaa aaagctgctg gtgtggcaga aagatatgat     3780

atcctgcttc taactgaaaa tggaatcctt ctgcgcaaca catcagagcc agccaccact     3840

aagcaacaca aatttgaaga tctaacacca ggcaagaaat acaagataca gatcctaact     3900

gtcagtggag gcctctttag caaggaagcc cagactgaag gccgaacagt cccagcagct     3960

gtcaccgacc tgaggatcac agagaactcc accaggcacc tgtccttccg ctggaccgcc     4020

tcagaggggg agctcagctg gtacaacatc tttttgtaca acccagatgg gaatctccag     4080

gagagagctc aagttgaccc actagtccag agcttctctt tccagaactt gctacaaggc     4140

agaatgtaca agatggtgat tgtaactcac agtggggagc tgtctaatga gtctttcata     4200

tttggtagaa cagtcccagc ctctgtgagt catctcaggg ggtccaatcg gaacacgaca     4260

gacagccttt ggttcaactg gagtccagcc tctggggact ttgactttta tgagctgatt     4320

ctctataatc ccaatggcac aaagaaggaa aactggaaag acaaggacct gacggagtgg     4380

cggtttcaag gccttgttcc tggaaggaag tacgtgctgt gggtggtaac tcacagtgga     4440

gatctcagca ataaagtcac agcggagagc agaacagctc caagtcctcc cagtcttatg     4500

tcatttgctg acattgcaaa cacatccttg gccatcacgt ggaaagggcc cccagactgg     4560

acagactaca acgactttga gctgcagtgg ttgcccagag atgcacttac tgtcttcaac     4620

ccctacaaca acagaaaatc agaaggacgc attgtgtatg gtcttcgtcc agggagatcc     4680

tatcaattca acgtcaagac tgtcagtggt gattcctgga aaacttacag caaaccaatt     4740

tttggatctg tgaggacaaa gcctgacaag atacaaaacc tgcattgccg gcctcagaac     4800

tccacggcca ttgcctgttc ttggatccct cctgattctg actttgatgg ttatagtatt     4860

gaatgccgga aaatggacac ccaagaagtt gagttttcca gaaagctgga gaaagaaaaa     4920

tctctgctca acatcatgat gctagtgccc cataagaggt acctggtgtc catcaaagtg     4980

cagtcggccg gcatgaccag cgaggtggtt gaagacagca ctatcacaat gatagaccgc     5040

ccccctcctc cacccccaca cattcgtgtg aatgaaaagg atgtgctaat tagcaagtct     5100

tccatcaact ttactgtcaa ctgcagctgg ttcagcgaca ccaatggagc tgtgaaatac     5160

ttcacagtgg tggtgagaga ggctgatggc agtgatgagc tgaagccaga acagcagcac     5220

cctctccctt cctacctgga gtacaggcac aatgcctcca ttcgggtgta tcagactaat     5280

tattttgcca gcaaatgtgc cgaaaatcct aacagcaact ccaagagttt taacattaag     5340

cttggagcag agatggagag cctaggtgga aaatgcgatc ccactcagca aaaattctgt     5400

gatggaccac tgaagccaca cactgcctac agaatcagca ttcgagcttt tacacagctc     5460

tttgatgagg acctgaagga attcacaaag ccactctatt cagacacatt tttttcttta     5520

cccatcacta ctgaatcaga gcccttgttt ggagctattg aaggtgtgag tgctggtctg     5580

tttttaattg gcatgctagt ggctgttgtt gccttattga tctgcagaca gaaagtgagc     5640

catggtcgag aaagaccctc tgcccgtctg agcattcgta gggatcgacc attatctgtc     5700

cacttaaacc tgggccagaa aggtaaccgg aaaacttctt gtccaataaa aataaatcag     5760

tttgaagggc atttcatgaa gctacaggct gactccaact accttctatc caaggaatac     5820

gaggagttaa aagacgtggg ccgaaaccag tcatgtgaca ttgcactctt gccggagaat     5880

agagggaaaa atcgatacaa caatatattg ccctatgatg ccacgcgagt gaagctctcc     5940

aatgtagatg atgatccttg ctctgactac atcaatgcca gctacatccc tggcaacaac     6000

ttcagaagag aatacattgt cactcaggga ccgcttcctg gcaccaagga tgacttctgg     6060

aaaatggtgt gggaacaaaa cgttcacaac atcgtcatgg tgacccagtg tgttgagaag     6120

ggccgagtaa agtgtgacca ttactggcca gcggaccagg attccctcta ctatggggac     6180

ctcatcctgc agatgctctc agagtccgtc ctgcctgagt ggaccatccg ggagtttaag     6240

atatgcggtg aggaacagct tgatgcacac agactcatcc gccactttca ctatacggtg     6300

tggccagacc atggagtccc agaaaccacc cagtctctga tccagtttgt gagaactgtc     6360

agggactaca tcaacagaag cccgggtgct gggcccactg tggtgcactg cagtgctggt     6420

gtgggtagga ctggaacctt tattgcattg gaccgaatcc tccagcagtt agactccaaa     6480

gactctgtgg acatttatgg agcagtgcac gacctaagac ttcacagggt tcacatggtc     6540

cagactgagt gtcagtatgt ctacctacat cagtgtgtaa gagatgtcct cagagcaaga     6600

aagctacgga gtgaacaaga aaaccccttg tttccaatct atgaaaatgt gaatccagag     6660

tatcacagag atccagtcta ttcaaggcat tgagaatgta cctgaagagc tcctggataa     6720

aaattattca ctgtgtgatt tgtttttaaa aacttgcttc atgccctaca gaggtgccag     6780

ctatttctgt tgatactatg tataatttat taatctggag aatgtttaaa attttatata     6840

atttaaaggt aacagatatt attgtacata gttgtatttt gtagtttctt ctgtaaatat     6900

gtatttttca taatgtttaa tattaagctt tatataatac tatttttcca cactaaagtg     6960

ttcatgactt gttctacata aaactaattc aacctgtatg acaggactac tggtaaaatg     7020

catatggagg tggtggcaga gacaatcctt caggccatgt tttctacctg ttttgatatt     7080

cactggacag gaaaaagggc agggctagag agagcaaata ctatggctag atttgctgca     7140

ttgctgtccc atgaatctcg agagccaaca gacatgtcct aacttgctat taggacaaat     7200

gtgacagtca aaaaaaggat tagagggagg gagaaaaaag aattaagcag taccaaagct     7260

gaactagatg cttgtgtctg aactagttgc tctctctctc ctttctcctt ccagggattc     7320

aagccaaagt ggtcagctca gggatcatgt aacttgcagt gcaagcccag gatggtagga     7380

tgcagggttg agggttctga tagagaatga ttccaaacag aagtgatgaa ttccttttgt     7440

taataagatg ccagctatac ccagactgga aacataacat gcaaagcact atctacagtg     7500

attagagatc ctttcattgc attcatggtg tggagtgtga acatccacac ccatactgta     7560

atgtatttat acacactagt ttctgtctca ttttcagtgg tctccattcc tagaaaagtc     7620

acaattatcc attcctactt gatttcccat taaaagaata ttatggtagc agattgtgcc     7680

cctcattaaa aggcttaatg ccaacatttt catagaaatg actacaaaca tcatatatag     7740

taaatttaaa aacaatagca aaaacaaaaa cagtggtctt cagtaaaatt ttcaaaactt     7800

cttttagtaa atcaatgaag tcaaaatgtc aagtaatcac ccaaagttgc atttaataac     7860

aaaaggcact acatactgta ccaagtttat cttcaatatt tgtgccttac ttactttgac     7920

tataacaaat tccaatgagt cagaaagtat ttccttcatc aaggtccagt tccgacagca     7980

ttcctgggaa aaatttgaaa ggagtttgta cggaatcttc atagatacct gagaagatga     8040

gctggagatg tttgcctttt tcacactaca aatttttctg taataaactt gggaattaga     8100

ggtcaagttt gttgatggca tagcttcctt tgcataaaga gtatatttct tttcaaagta     8160

tatatttttg taacctacca taaagtccgt aagtgaatac aacgaatgta attgacataa     8220

taattgaaaa tcattgacta tacctaaaat agttctttat aattaaataa ctctacaccc     8280

aatctggaaa tttttccaag gttatttgaa gtttacaaaa atgtgaagca taatcataag     8340

cttcaaagat tcacagtttc attgtgctca atgctcttgt gaaatgacag tcttaagctc     8400

tgattctgta tcaaggaact aagtgaatct tctggaaatg aaaaggaaca acatatgtgt     8460

aagtgcagta gatgtaccac cagcgagaaa atagaggtca gagatctaca acgtgtggca     8520

tccattagaa atcacctttc ctacattgaa aagaaaaaag agaaaaagca gaattttaca     8580

ctaatgttgc ttgatgcaaa gcacattaat gcttggaagg atacattcat tttcgacttt     8640

tcattcactc agaaaacttc tagtaagtat ctgcaacctg ctaggcactg ttccagaatc     8700

tacacatttc tactcacata aagagaatcc tcataaagtt aggattgttg ttactacctt     8760

caattgagct taaaagacag cctcatcaag ggaatgggat aactgagcca gtctaggaca     8820

gtggtcacct tccacaggcc acacactgga aagtgctaat gctactttaa tagcaaacct     8880

ctggatctag gagagagagc aattaattgc acaaaccagg agttaaaacc ataaaaaaaa     8940

cctatgcatc tgtaatagta aataacactc acgtactctg gcaacatcta gggtagtatc     9000

agaattatgt aaatggacat gacagggaaa aatcgtaggt ttttttagtc taatccaacc     9060

caggaaatgt ttattcctac cctacaccta attttaaacc ttcttagcaa caaatatttc     9120

actattcgct cctactcctg ggaagactaa atatataatt gacttattta ttaaatttag     9180

gagaaaaaaa aagttttcct tgacattcag ctctattgga tttatttcca tttaattgca     9240

tcatgtgtta tgtcttggta aacactccat ttcctgtctt ggtgggcatc ctgtctgtgt     9300

acctgtgcag tacactttaa tcatcaagac ttcaaagtgc ttttgagcta tcaaatcttg     9360

ggagagtccc atctagcatc ttaataatta tttttccaag ttcgttataa ttaactcctt     9420

taacctcatc tcattaaatc aattttgtat tgtcattctg ttgttctctg gaaagcagcc     9480

aattgttcag ctcttgaatc agaattttca aagactcacc tctcttacct gggcttgcac     9540

atatttgtcc taagtaattc tctatccctt aaacctctga gtccctctgt tttattactt     9600

gccccactcc tcctacttga atatgtttgt tttcccagtt gaatgtgatt tttatctact     9660

gttcatatta tcttttatac ccatgagtat aatttcatag tcctttcagg ttccacatca     9720

tcaaagagat gaccataatt tcactttttt ttgaaatgaa gtcttgctct gttgcccagg     9780

ctggagtgca gtggcacaat ctcagctcac tacaacctcc gcctcccagg ttcaagcgat     9840

tctgccttag cctcccaagt agctggaatt acaggtgcct gccaccatgt ctggctaatt     9900

tttgtgtttt tagtagagat ggggtttcac catgttggcc aggctggtct tgaactcgtg     9960

accttaggtg atccacccac ctcaacctcc caaagtgcta ggattacaag agtgagccac    10020

cgcacctggc caattcactt ttaaatacta aaaggcacac agcacacaga cattttcggg    10080

gcagttttct ttgggagggt ctttgataaa ttttgtaatc acctctcgga agaaagccca    10140

aaatgacatg tgaaaataat attaaaccat ttaccagatg tccagcaata taaaaataga    10200

cctcacatgc tacccttcac atgctgattc tcttgccttg ctgtttaagg atccagtttc    10260

ttatgttaaa cattttcctt accttttgca ataatattat tggccatata ctaaattctc    10320

attcacttag ctttctaaga attctttgag gttggaatcc tgaaatcata aagctaccag    10380

atctgcacaa cagcagtggt agtatctgag cccaaactct gagacgctct agagttttag    10440

tttacaaaca tgagccagac caaacctgac ctggtgaaaa tcaataggta ataaactgct    10500

tgtatatgat agcagttcaa gggctttctg ggttccattt cactgaggaa atgaaaatat    10560

aactgattag ccaagacaga gtggcaataa ggaataactg atcctcctcc aagttgcagt    10620

gagcaagccc tcaagcctac ctcattcctg aagagttgaa ggagaaaatg ccgtgctaat    10680

tttctgccct gctattttta acctgaaatt tagaattaca tcaggtattc aaagaatgtt    10740

ccctatcaaa ggaaaatctg taaacgatga ctgcaaaaag caagtgaaat gatgcaaaga    10800

gaaaatattt gcaaaacaga atctaaccag acatcatcat gaagataaaa tggcatctct    10860

tctgtgtggc ctgggtgtgc ttggacaatc ctgtcacacg tttctattag gacatgttgc    10920

ccttttgagg attcactcta tgttggccag atggtttaac tgattaaaca attgaatcaa    10980

tttattttgc tttttgaatt gaccagatat ttaactaaat gtactgggtt tggcatttta    11040

gacacactgc cttagattct tgtagtgcat gatgactttg aaaatgtttg gccattttag    11100

ttaaaatgca gggtaacatt tgatgcagcc atgataacag gaaaaatctg ttctgttcta    11160

aaaatgtttc tagcaataga agtatttctg gctaagagaa tactcttgac ttgtagggag    11220

gctccctcgg aataaatgta tgcaacacaa ataaggcatt ttatttttta aaagattgtc    11280

tatataagat acacttatta aataaagaaa ttgttggtga atgctctgaa aa            11332


<210>  394
<211>  2215
<212>  PRT
<213>  Homo Sapiens

<400>  394

Met Glu Ala Glu Phe Tyr Met Val Ile Leu Thr Cys Leu Ile Phe Arg 
1               5                   10                  15      


Asn Ser Glu Gly Phe Gln Ile Val His Val Gln Lys Gln Gln Cys Leu 
            20                  25                  30          


Phe Lys Asn Glu Lys Val Val Val Gly Ser Cys Asn Arg Thr Ile Gln 
        35                  40                  45              


Asn Gln Gln Trp Met Trp Thr Glu Asp Glu Lys Leu Leu His Val Lys 
    50                  55                  60                  


Ser Ala Leu Cys Leu Ala Ile Ser Asn Ser Ser Arg Gly Pro Ser Arg 
65                  70                  75                  80  


Ser Ala Ile Leu Asp Arg Cys Ser Gln Ala Pro Arg Trp Thr Cys Tyr 
                85                  90                  95      


Asp Gln Glu Gly Phe Leu Glu Val Glu Asn Ala Ser Leu Phe Leu Gln 
            100                 105                 110         


Lys Gln Gly Ser Arg Val Val Val Lys Lys Ala Arg Lys Tyr Leu His 
        115                 120                 125             


Ser Trp Met Lys Ile Asp Val Asn Lys Glu Gly Lys Leu Val Asn Glu 
    130                 135                 140                 


Ser Leu Cys Leu Gln Lys Ala Gly Leu Gly Ala Glu Val Ser Val Arg 
145                 150                 155                 160 


Ser Thr Arg Asn Thr Ala Pro Pro Gln Ile Leu Thr Thr Phe Asn Ala 
                165                 170                 175     


Val Pro Asp Gly Leu Val Phe Leu Ile Arg Asn Thr Thr Glu Ala Phe 
            180                 185                 190         


Ile Arg Asn Ala Ala Glu Asn Tyr Ser Gln Asn Ser Ser Glu Arg Gln 
        195                 200                 205             


His Pro Asn Leu His Met Thr Gly Ile Thr Asp Thr Ser Trp Val Leu 
    210                 215                 220                 


Ser Thr Thr Gln Pro Phe Ser Ser Thr Thr Glu Glu Thr Gly Leu Ala 
225                 230                 235                 240 


Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala Glu Ser Lys Ala Ser Ser 
                245                 250                 255     


His Ser Val Ser Ile Gln Trp Arg Ile Leu Gly Ser Pro Cys Asn Phe 
            260                 265                 270         


Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly Ala Ala Leu Cys Pro Thr 
        275                 280                 285             


Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys Asn Leu Gln Asp Leu Gln 
    290                 295                 300                 


Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile Ser Leu Asp Glu Glu Arg 
305                 310                 315                 320 


Thr Val Val Leu Gln Thr Asp Pro Leu Pro Pro Ala Arg Phe Gly Val 
                325                 330                 335     


Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu His Val Trp Trp Thr Pro 
            340                 345                 350         


Ser Ser Gly Lys Val Thr Ser Tyr Glu Val Gln Leu Phe Asp Glu Asn 
        355                 360                 365             


Asn Gln Lys Ile Gln Gly Val Gln Ile Gln Glu Ser Thr Ser Trp Asn 
    370                 375                 380                 


Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly Ser Lys Tyr Asn Ile Ala 
385                 390                 395                 400 


Ile Thr Ala Val Ser Gly Gly Lys Arg Ser Phe Ser Val Tyr Thr Asn 
                405                 410                 415     


Gly Ser Thr Val Pro Ser Pro Val Lys Asp Ile Gly Ile Ser Thr Lys 
            420                 425                 430         


Ala Asn Ser Leu Leu Ile Ser Trp Ser His Gly Ser Gly Asn Val Glu 
        435                 440                 445             


Arg Tyr Arg Leu Met Leu Met Asp Lys Gly Ile Leu Val His Gly Gly 
    450                 455                 460                 


Val Val Asp Lys His Ala Thr Ser Tyr Ala Phe His Gly Leu Thr Pro 
465                 470                 475                 480 


Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr Glu Ala Ala Gly Leu Gln 
                485                 490                 495     


Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala Pro Met Glu Val Ser Asn 
            500                 505                 510         


Leu Lys Val Thr Asn Asp Gly Ser Leu Thr Ser Leu Lys Val Lys Trp 
        515                 520                 525             


Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr Asn Ile Thr Leu Ser His 
    530                 535                 540                 


Lys Gly Thr Ile Lys Glu Ser Arg Val Leu Ala Pro Trp Ile Thr Glu 
545                 550                 555                 560 


Thr His Phe Lys Glu Leu Val Pro Gly Arg Leu Tyr Gln Val Thr Val 
                565                 570                 575     


Ser Cys Val Ser Gly Glu Leu Ser Ala Gln Lys Met Ala Val Gly Arg 
            580                 585                 590         


Thr Phe Pro Asp Lys Val Ala Asn Leu Glu Ala Asn Asn Asn Gly Arg 
        595                 600                 605             


Met Arg Ser Leu Val Val Ser Trp Ser Pro Pro Ala Gly Asp Trp Glu 
    610                 615                 620                 


Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser Val Val Leu Leu Asn Ile 
625                 630                 635                 640 


Thr Val Gly Lys Glu Glu Thr Gln Tyr Val Met Asp Asp Thr Gly Leu 
                645                 650                 655     


Val Pro Gly Arg Gln Tyr Glu Val Glu Val Ile Val Glu Ser Gly Asn 
            660                 665                 670         


Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg Thr Val Pro Leu Ala Val 
        675                 680                 685             


Leu Gln Leu Arg Val Lys His Ala Asn Glu Thr Ser Leu Ser Ile Met 
    690                 695                 700                 


Trp Gln Thr Pro Val Ala Glu Trp Glu Lys Tyr Ile Ile Ser Leu Ala 
705                 710                 715                 720 


Asp Arg Asp Leu Leu Leu Ile His Lys Ser Leu Ser Lys Asp Ala Lys 
                725                 730                 735     


Glu Phe Thr Phe Thr Asp Leu Val Pro Gly Arg Lys Tyr Met Ala Thr 
            740                 745                 750         


Val Thr Ser Ile Ser Gly Asp Leu Lys Asn Ser Ser Ser Val Lys Gly 
        755                 760                 765             


Arg Thr Val Pro Ala Gln Val Thr Asp Leu His Val Ala Asn Gln Gly 
    770                 775                 780                 


Met Thr Ser Ser Leu Phe Thr Asn Trp Thr Gln Ala Gln Gly Asp Val 
785                 790                 795                 800 


Glu Phe Tyr Gln Val Leu Leu Ile His Glu Asn Val Val Ile Lys Asn 
                805                 810                 815     


Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr Ser Phe His Ser Leu Lys 
            820                 825                 830         


Ser Gly Ser Leu Tyr Ser Val Val Val Thr Thr Val Ser Gly Gly Ile 
        835                 840                 845             


Ser Ser Arg Gln Val Val Val Glu Gly Arg Thr Val Pro Ser Ser Val 
    850                 855                 860                 


Ser Gly Val Thr Val Asn Asn Ser Gly Arg Asn Asp Tyr Leu Ser Val 
865                 870                 875                 880 


Ser Trp Leu Leu Ala Pro Gly Asp Val Asp Asn Tyr Glu Val Thr Leu 
                885                 890                 895     


Ser His Asp Gly Lys Val Val Gln Ser Leu Val Ile Ala Lys Ser Val 
            900                 905                 910         


Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro Gly Arg Leu Tyr Thr Val 
        915                 920                 925             


Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu Asn His Ser Phe Ser Gln 
    930                 935                 940                 


Glu Arg Thr Val Pro Asp Lys Val Gln Gly Val Ser Val Ser Asn Ser 
945                 950                 955                 960 


Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp Val His Ala Thr Gly Asp 
                965                 970                 975     


Phe Asp His Tyr Glu Val Thr Ile Lys Asn Lys Asn Asn Phe Ile Gln 
            980                 985                 990         


Thr Lys Ser Ile Pro Lys Ser Glu  Asn Glu Cys Val Phe  Val Gln Leu 
        995                 1000                 1005             


Val Pro  Gly Arg Leu Tyr Ser  Val Thr Val Thr Thr  Lys Ser Gly 
    1010                 1015                 1020             


Gln Tyr  Glu Ala Asn Glu Gln  Gly Asn Gly Arg Thr  Ile Pro Glu 
    1025                 1030                 1035             


Pro Val  Lys Asp Leu Thr Leu  Arg Asn Arg Ser Thr  Glu Asp Leu 
    1040                 1045                 1050             


His Val  Thr Trp Ser Gly Ala  Asn Gly Asp Val Asp  Gln Tyr Glu 
    1055                 1060                 1065             


Ile Gln  Leu Leu Phe Asn Asp  Met Lys Val Phe Pro  Pro Phe His 
    1070                 1075                 1080             


Leu Val  Asn Thr Ala Thr Glu  Tyr Arg Phe Thr Ser  Leu Thr Pro 
    1085                 1090                 1095             


Gly Arg  Gln Tyr Lys Ile Leu  Val Leu Thr Ile Ser  Gly Asp Val 
    1100                 1105                 1110             


Gln Gln  Ser Ala Phe Ile Glu  Gly Phe Thr Val Pro  Ser Ala Val 
    1115                 1120                 1125             


Lys Asn  Ile His Ile Ser Pro  Asn Gly Ala Thr Asp  Ser Leu Thr 
    1130                 1135                 1140             


Val Asn  Trp Thr Pro Gly Gly  Gly Asp Val Asp Ser  Tyr Thr Val 
    1145                 1150                 1155             


Ser Ala  Phe Arg His Ser Gln  Lys Val Asp Ser Gln  Thr Ile Pro 
    1160                 1165                 1170             


Lys His  Val Phe Glu His Thr  Phe His Arg Leu Glu  Ala Gly Glu 
    1175                 1180                 1185             


Gln Tyr  Gln Ile Met Ile Ala  Ser Val Ser Gly Ser  Leu Lys Asn 
    1190                 1195                 1200             


Gln Ile  Asn Val Val Gly Arg  Thr Val Pro Ala Ser  Val Gln Gly 
    1205                 1210                 1215             


Val Ile  Ala Asp Asn Ala Tyr  Ser Ser Tyr Ser Leu  Ile Val Ser 
    1220                 1225                 1230             


Trp Gln  Lys Ala Ala Gly Val  Ala Glu Arg Tyr Asp  Ile Leu Leu 
    1235                 1240                 1245             


Leu Thr  Glu Asn Gly Ile Leu  Leu Arg Asn Thr Ser  Glu Pro Ala 
    1250                 1255                 1260             


Thr Thr  Lys Gln His Lys Phe  Glu Asp Leu Thr Pro  Gly Lys Lys 
    1265                 1270                 1275             


Tyr Lys  Ile Gln Ile Leu Thr  Val Ser Gly Gly Leu  Phe Ser Lys 
    1280                 1285                 1290             


Glu Ala  Gln Thr Glu Gly Arg  Thr Val Pro Ala Ala  Val Thr Asp 
    1295                 1300                 1305             


Leu Arg  Ile Thr Glu Asn Ser  Thr Arg His Leu Ser  Phe Arg Trp 
    1310                 1315                 1320             


Thr Ala  Ser Glu Gly Glu Leu  Ser Trp Tyr Asn Ile  Phe Leu Tyr 
    1325                 1330                 1335             


Asn Pro  Asp Gly Asn Leu Gln  Glu Arg Ala Gln Val  Asp Pro Leu 
    1340                 1345                 1350             


Val Gln  Ser Phe Ser Phe Gln  Asn Leu Leu Gln Gly  Arg Met Tyr 
    1355                 1360                 1365             


Lys Met  Val Ile Val Thr His  Ser Gly Glu Leu Ser  Asn Glu Ser 
    1370                 1375                 1380             


Phe Ile  Phe Gly Arg Thr Val  Pro Ala Ser Val Ser  His Leu Arg 
    1385                 1390                 1395             


Gly Ser  Asn Arg Asn Thr Thr  Asp Ser Leu Trp Phe  Asn Trp Ser 
    1400                 1405                 1410             


Pro Ala  Ser Gly Asp Phe Asp  Phe Tyr Glu Leu Ile  Leu Tyr Asn 
    1415                 1420                 1425             


Pro Asn  Gly Thr Lys Lys Glu  Asn Trp Lys Asp Lys  Asp Leu Thr 
    1430                 1435                 1440             


Glu Trp  Arg Phe Gln Gly Leu  Val Pro Gly Arg Lys  Tyr Val Leu 
    1445                 1450                 1455             


Trp Val  Val Thr His Ser Gly  Asp Leu Ser Asn Lys  Val Thr Ala 
    1460                 1465                 1470             


Glu Ser  Arg Thr Ala Pro Ser  Pro Pro Ser Leu Met  Ser Phe Ala 
    1475                 1480                 1485             


Asp Ile  Ala Asn Thr Ser Leu  Ala Ile Thr Trp Lys  Gly Pro Pro 
    1490                 1495                 1500             


Asp Trp  Thr Asp Tyr Asn Asp  Phe Glu Leu Gln Trp  Leu Pro Arg 
    1505                 1510                 1515             


Asp Ala  Leu Thr Val Phe Asn  Pro Tyr Asn Asn Arg  Lys Ser Glu 
    1520                 1525                 1530             


Gly Arg  Ile Val Tyr Gly Leu  Arg Pro Gly Arg Ser  Tyr Gln Phe 
    1535                 1540                 1545             


Asn Val  Lys Thr Val Ser Gly  Asp Ser Trp Lys Thr  Tyr Ser Lys 
    1550                 1555                 1560             


Pro Ile  Phe Gly Ser Val Arg  Thr Lys Pro Asp Lys  Ile Gln Asn 
    1565                 1570                 1575             


Leu His  Cys Arg Pro Gln Asn  Ser Thr Ala Ile Ala  Cys Ser Trp 
    1580                 1585                 1590             


Ile Pro  Pro Asp Ser Asp Phe  Asp Gly Tyr Ser Ile  Glu Cys Arg 
    1595                 1600                 1605             


Lys Met  Asp Thr Gln Glu Val  Glu Phe Ser Arg Lys  Leu Glu Lys 
    1610                 1615                 1620             


Glu Lys  Ser Leu Leu Asn Ile  Met Met Leu Val Pro  His Lys Arg 
    1625                 1630                 1635             


Tyr Leu  Val Ser Ile Lys Val  Gln Ser Ala Gly Met  Thr Ser Glu 
    1640                 1645                 1650             


Val Val  Glu Asp Ser Thr Ile  Thr Met Ile Asp Arg  Pro Pro Pro 
    1655                 1660                 1665             


Pro Pro  Pro His Ile Arg Val  Asn Glu Lys Asp Val  Leu Ile Ser 
    1670                 1675                 1680             


Lys Ser  Ser Ile Asn Phe Thr  Val Asn Cys Ser Trp  Phe Ser Asp 
    1685                 1690                 1695             


Thr Asn  Gly Ala Val Lys Tyr  Phe Thr Val Val Val  Arg Glu Ala 
    1700                 1705                 1710             


Asp Gly  Ser Asp Glu Leu Lys  Pro Glu Gln Gln His  Pro Leu Pro 
    1715                 1720                 1725             


Ser Tyr  Leu Glu Tyr Arg His  Asn Ala Ser Ile Arg  Val Tyr Gln 
    1730                 1735                 1740             


Thr Asn  Tyr Phe Ala Ser Lys  Cys Ala Glu Asn Pro  Asn Ser Asn 
    1745                 1750                 1755             


Ser Lys  Ser Phe Asn Ile Lys  Leu Gly Ala Glu Met  Glu Ser Leu 
    1760                 1765                 1770             


Gly Gly  Lys Cys Asp Pro Thr  Gln Gln Lys Phe Cys  Asp Gly Pro 
    1775                 1780                 1785             


Leu Lys  Pro His Thr Ala Tyr  Arg Ile Ser Ile Arg  Ala Phe Thr 
    1790                 1795                 1800             


Gln Leu  Phe Asp Glu Asp Leu  Lys Glu Phe Thr Lys  Pro Leu Tyr 
    1805                 1810                 1815             


Ser Asp  Thr Phe Phe Ser Leu  Pro Ile Thr Thr Glu  Ser Glu Pro 
    1820                 1825                 1830             


Leu Phe  Gly Ala Ile Glu Gly  Val Ser Ala Gly Leu  Phe Leu Ile 
    1835                 1840                 1845             


Gly Met  Leu Val Ala Val Val  Ala Leu Leu Ile Cys  Arg Gln Lys 
    1850                 1855                 1860             


Val Ser  His Gly Arg Glu Arg  Pro Ser Ala Arg Leu  Ser Ile Arg 
    1865                 1870                 1875             


Arg Asp  Arg Pro Leu Ser Val  His Leu Asn Leu Gly  Gln Lys Gly 
    1880                 1885                 1890             


Asn Arg  Lys Thr Ser Cys Pro  Ile Lys Ile Asn Gln  Phe Glu Gly 
    1895                 1900                 1905             


His Phe  Met Lys Leu Gln Ala  Asp Ser Asn Tyr Leu  Leu Ser Lys 
    1910                 1915                 1920             


Glu Tyr  Glu Glu Leu Lys Asp  Val Gly Arg Asn Gln  Ser Cys Asp 
    1925                 1930                 1935             


Ile Ala  Leu Leu Pro Glu Asn  Arg Gly Lys Asn Arg  Tyr Asn Asn 
    1940                 1945                 1950             


Ile Leu  Pro Tyr Asp Ala Thr  Arg Val Lys Leu Ser  Asn Val Asp 
    1955                 1960                 1965             


Asp Asp  Pro Cys Ser Asp Tyr  Ile Asn Ala Ser Tyr  Ile Pro Gly 
    1970                 1975                 1980             


Asn Asn  Phe Arg Arg Glu Tyr  Ile Val Thr Gln Gly  Pro Leu Pro 
    1985                 1990                 1995             


Gly Thr  Lys Asp Asp Phe Trp  Lys Met Val Trp Glu  Gln Asn Val 
    2000                 2005                 2010             


His Asn  Ile Val Met Val Thr  Gln Cys Val Glu Lys  Gly Arg Val 
    2015                 2020                 2025             


Lys Cys  Asp His Tyr Trp Pro  Ala Asp Gln Asp Ser  Leu Tyr Tyr 
    2030                 2035                 2040             


Gly Asp  Leu Ile Leu Gln Met  Leu Ser Glu Ser Val  Leu Pro Glu 
    2045                 2050                 2055             


Trp Thr  Ile Arg Glu Phe Lys  Ile Cys Gly Glu Glu  Gln Leu Asp 
    2060                 2065                 2070             


Ala His  Arg Leu Ile Arg His  Phe His Tyr Thr Val  Trp Pro Asp 
    2075                 2080                 2085             


His Gly  Val Pro Glu Thr Thr  Gln Ser Leu Ile Gln  Phe Val Arg 
    2090                 2095                 2100             


Thr Val  Arg Asp Tyr Ile Asn  Arg Ser Pro Gly Ala  Gly Pro Thr 
    2105                 2110                 2115             


Val Val  His Cys Ser Ala Gly  Val Gly Arg Thr Gly  Thr Phe Ile 
    2120                 2125                 2130             


Ala Leu  Asp Arg Ile Leu Gln  Gln Leu Asp Ser Lys  Asp Ser Val 
    2135                 2140                 2145             


Asp Ile  Tyr Gly Ala Val His  Asp Leu Arg Leu His  Arg Val His 
    2150                 2155                 2160             


Met Val  Gln Thr Glu Cys Gln  Tyr Val Tyr Leu His  Gln Cys Val 
    2165                 2170                 2175             


Arg Asp  Val Leu Arg Ala Arg  Lys Leu Arg Ser Glu  Gln Glu Asn 
    2180                 2185                 2190             


Pro Leu  Phe Pro Ile Tyr Glu  Asn Val Asn Pro Glu  Tyr His Arg 
    2195                 2200                 2205             


Asp Pro  Val Tyr Ser Arg His  
    2210                 2215 


<210>  395
<211>  5888
<212>  DNA
<213>  Homo Sapiens

<400>  395
acttctgaca gtggggaaag cagctgtgtg tgatagcttg gaaggtttac tgctgcctca       60

agtcctcttc tctgcagttg aggtttcagg tttcaatcct cccaatacca caagacagag      120

cacggggcgg ctgccgcctc cgcctccgcg ccttaaccta ggcggcttgc cgaagatctc      180

agccccgcgg ccgcgcgctc gccctgccct agaccagggt tgggcgcagc ggcggaggtg      240

gcttctgggc tgcgcgagct gggagagctg ggaggcggcg atcgcagctg ggccgggact      300

tccttcctcc accgcacggc aacaaaacaa ccctgcggca ggcactgagt gcttcgcagc      360

tgtctgggcg agaggcacag cgatgggctc cgtgctgagc accgacagcg gcaaatcggc      420

gcccgcctct gccaccgcgc gggccctgga gcgcaggagg gacccggagt tgcccgtcac      480

gtccttcgac tgcgccgtgt gccttgaggt gttacaccag cctgtccgga cccgctgtgg      540

ccacgtattc tgccgttcct gtattgctac cagtctaaag aacaacaagt ggacctgtcc      600

ttattgccgg gcatatcttc cttcagaagg agttccagca actgatgtag ccaaaagaat      660

gaaatcagag tataagaact gcgctgagtg tgacaccctg gtttgcctca gtgaaatgag      720

ggcacatatt cggacttgtc agaagtacat agataagtat ggaccactac aagaacttga      780

ggagacagca gcaaggtgtg tatgtccctt ttgtcagagg gaactgtatg aagacagctt      840

gctggatcat tgtattactc atcacagatc ggaacggagg cctgtgttct gtccactttg      900

ccgtttaata cccgatgaga atccaagcag cttcagtggc agtttaataa gacatctgca      960

agttagtcac actttgtttt atgatgattt catagatttt aatataattg aggaagctct     1020

tatccgaaga gtcttagacc ggtcacttct tgaatatgtg aatcactcga acaccacata     1080

attttattaa aacgaaggga aaagggacca ctgaattgca ccatttaaga tgctgcttga     1140

acaaatggga gggaagttgt caatgattga tgggcaaaaa tgtacaacac agttatgtgt     1200

ttgtccatgt ttattgttat agtgcattta aaaactgctt taattttaat ggtttaaatc     1260

tgttttacat ccttgagatt cttacacatc taacaacaaa aaaaattatc tacatcagtc     1320

attgttacat ggaaaagaca ggtggtaggc aagtaggtgg aggatctcgg tttgcaaatt     1380

agataatact ctgtgtataa tgctacatat caataactac catcatggtt aggcacgata     1440

actaatcttt gttctgtgta aaaaaatatg gagagtgaaa caaagtgcag acattcaaag     1500

aaataagaaa tctgctccaa tgctcttgtt ctaatctcta ataggttaac gttaataatc     1560

ttgtatggga gttggaaagg aaaattttgg aagtcaagaa agtccattta ggccggacgc     1620

ggtggcttac gcttgtaatc ccagcacttt gggaggctga agcaggcgga tcacaaggtc     1680

aggagttcga gaccagcctg gccaacactg gtctctgtga aactccgtct ctactaaaaa     1740

tacaaaaatt agctggacgt gttggcgggc atctgtaata ccagctactt gggaggctga     1800

ggcagaagaa tcacttgaac ccgggaggca gaggttacag tgagctgaga tcgcaccagt     1860

acactccagc ctgggtaaca gagctagact ccatctcaaa aaaaaaaaaa aaaaaaatcc     1920

atttaaccaa attgtcttac ataatactgt aacaaaacaa attttgtgtt agaaaagtat     1980

acttaattct ttgacttttt ataactgcat acataagaat tcaatatttt tcaaatattt     2040

atagcttatt tagaaatatt tctataatat aagcaatttc ttaaaaacca tcagatgata     2100

cttacagtat aagtattcac atccagactt tttagtagaa aaccctaagg gctttgatat     2160

cttttttgat tgtaacattt taaaaattat gaaataaaag tactgaaaac cagacacaaa     2220

atttatagct gaatgcctta ttataaggaa atactctttt aggactcagc cagtcacccc     2280

acgtgtcctt tttgtgtcct gtcacaatta caaccccaca aaagtaactg ctagactgat     2340

ttaaatggta atcactttgt tgcatttgat tactgctgcc acacctaaat gcatatatct     2400

atattttaat attatcaatt taaagttgtt attaaatgta tattttattt tacatctctt     2460

ttttaatcta gaagttcctc cttctttcca gttccttaaa atttacctgg tgaagaacct     2520

gatcctagga cctatagagt ttcccatact ttgtattttg ctgattgcac actcatggca     2580

cggttcagca cattgccctg tcctctcgat attagcacac agtgcaggtt caggcacatt     2640

gaatttgaga agacttaggt tcagtccttt ggcaagactg taaatcacgg tgtctttctt     2700

tccttcctcc ttcttctctc tctctctctc tctctctttc cttttctttc tctttttttc     2760

agagttgcac tctgttgccc aggctggagt acagtggcac gatctcgact cactgcaacc     2820

tccatctccc gggttcaagc agttctcctg tttcagcctc ccaagtagct gggactacag     2880

gtgcacgcca ccatgcccgg ctaatttttg tatttttagt agaggggttt caccataatg     2940

gtcaggctgg tcttgaactc ctgaactcaa gtgatccacc agccttggcc tcccaaaatg     3000

ctgggattac aggcatgagc caccatgccc agctaatttt tgtattttta gtagagacag     3060

ggtttcacca taatagccag gctggtctca aactccttac cttgtgatcc gcccacctca     3120

gccttccaaa gtgctgggat tataggcgtg agccactgtg cccggcctac agggttttta     3180

tctaaccttt ctgttacaac tgtacctctc cttctgtact gaaagtcctg gttttcaaga     3240

acacagggca cgatagaatt agaacatccc acaattactc atttctttta tttatcttac     3300

acttacagct gtctcagaat aacaatagaa atacaaccac aaataatatg gcaattgaaa     3360

caattaaaaa gttttcattt gcttttctca ttctttccca attttttttt ttttttgaga     3420

tggagtctcg cgctcttgtt gcccaggctg gagtgcaatg gcacgatctc ggctcactgc     3480

aacctctgcc tcctggattc aagcaattct cctgcctcag cttcccgagt agctgggatt     3540

ataggcatgc gccaccacgc cctgctaatt ttgtattttt agtagagtca ggatttctcc     3600

acattggtca ggctggcctc aaactctcga cctcaggtga tccgcctgcc tcggcctccc     3660

aaagtgctgg gattacaggt gtgagccact gcgcccgaca tcccaatttt taaaatagtt     3720

atactatgtc aacattttca gaacatactg gtatagcata ctgtactttc ttccttttat     3780

cccccattta ttcttagttc ttcaactata tatttaacac ttgcccccag ttttgttttg     3840

ttttgttttg aggaggaatc ttgctctgtt gcccaggctg gagtgcagtg gtgtgatctt     3900

ggctcactgc aacctccgcc tcccgggttc aagtgattct cctgcctcag cctctcgagt     3960

agctgggatt acaagtgggc accaccacac ccggctaatt gttgtatttt tagtagagat     4020

gggttttgcc atgttggcca ggctggtttt gaactcctga cctcaagtga tccacctgtg     4080

ttggcctcct aaagtactgg gattacaggt gtgtgccacc gcgccaggca attgccccca     4140

gtttttattt gatggctctg actgtttctc atatctgact ctttaattat gaatccaggg     4200

catagattag tatctccatc ttgtaaggat gcaaagaagc catgaaaata agtaatatca     4260

actcctgagg ataaaacgtt acttgactag agttagcttt ttaattgtaa tcatttataa     4320

acttctttgt tccttacata taagcatagt cataaccatg gtacccaaaa ttttctataa     4380

gttattgtaa ctccttaaag gtcttgctac agttctttta tccagtacaa ataattggga     4440

aaatgtaaag ctgaatgaaa tctagtgagc ctcatatcct cccttttaga tattgatttt     4500

aagtttgctt ttcacagctg ctaaaaagta acaactgatt tttagttcca caacctctct     4560

ttcttcaatt tagatggatc atacaataaa gcaaaatctg gctggttaca gtggctcaca     4620

cctataatcc cagcactttg ggaggctgag gtggagggtc tcatgagccc aggagttcaa     4680

gaccaacctg ggcaatatag tgagactctt tctatttaaa caaaaacaaa aacaaacaaa     4740

caaacaaaca aaaagctggg catgatgcac acctttagtt tcagctacta aggaggctga     4800

ggttggagga tcacttgagc ctaggaggtc aacactgcag tgagctatga tcatgctact     4860

gccctccagc ctgggcaaca gagcaagacc ctgtctccaa aaacataaat aattaaatat     4920

aaataaaaat aaagcaaaat ctgttgggaa acgagaaaaa ggagaggaat ttttcaggaa     4980

taatcataaa aagaaatgat catcagactg aaagtccaga gcctgagaaa tgaaaacata     5040

tttttaagca ttggtgttga ccatgcagac aaacttttgt taattcagag cgatacaaaa     5100

ggcactttga atctataaaa cttgaaaaag ttaaaaattg tatgtcggat aaagctttaa     5160

gtcatctgtc actattaacc tcagtgcagc aattctgact cctgtgcctg gattcctttt     5220

atgataattt tgccacctac aggacagatt aggtgctggt cgcctgaatt attttgtgtt     5280

ctgaattatt ttgagctcta aaatggtaaa gtacaaatac tcattgtttt actgtgcctt     5340

tggcctttta taaaaaggta tttataattc gttgataaaa accaatattt gaagctgttg     5400

attaccaaca aaaaagtttc actctcttta tagtgcttca ggatacaact ttttcagggc     5460

cttattagag aaaaactgat tcacatgtta ttcttctaaa gctaaattat taaaatgtag     5520

gttgaaagat tggattgatt gtgaatctac actaaagata tggttccagg cagacctcct     5580

tagagacctc caggcagacc tccttactgt cttcagtgat gtttaatttc attactgtta     5640

ctgggtgcca agtgtctttc atttggaagt gaacttactc cagttattga atgtttatca     5700

tatcataatt tgcatttttc caacattgaa ggtattttaa aaagtcacta agagattcat     5760

tcttttatta ttcaactaca aaaaaatagt gtaatgatca gaatttaaaa tgtgtgattc     5820

tttttcttct gtaagtatgt attgctatga taaataaaaa atggcaggac cattgttttt     5880

attaaaat                                                              5888


<210>  396
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  396

Met Gly Ser Val Leu Ser Thr Asp Ser Gly Lys Ser Ala Pro Ala Ser 
1               5                   10                  15      


Ala Thr Ala Arg Ala Leu Glu Arg Arg Arg Asp Pro Glu Leu Pro Val 
            20                  25                  30          


Thr Ser Phe Asp Cys Ala Val Cys Leu Glu Val Leu His Gln Pro Val 
        35                  40                  45              


Arg Thr Arg Cys Gly His Val Phe Cys Arg Ser Cys Ile Ala Thr Ser 
    50                  55                  60                  


Leu Lys Asn Asn Lys Trp Thr Cys Pro Tyr Cys Arg Ala Tyr Leu Pro 
65                  70                  75                  80  


Ser Glu Gly Val Pro Ala Thr Asp Val Ala Lys Arg Met Lys Ser Glu 
                85                  90                  95      


Tyr Lys Asn Cys Ala Glu Cys Asp Thr Leu Val Cys Leu Ser Glu Met 
            100                 105                 110         


Arg Ala His Ile Arg Thr Cys Gln Lys Tyr Ile Asp Lys Tyr Gly Pro 
        115                 120                 125             


Leu Gln Glu Leu Glu Glu Thr Ala Ala Arg Cys Val Cys Pro Phe Cys 
    130                 135                 140                 


Gln Arg Glu Leu Tyr Glu Asp Ser Leu Leu Asp His Cys Ile Thr His 
145                 150                 155                 160 


His Arg Ser Glu Arg Arg Pro Val Phe Cys Pro Leu Cys Arg Leu Ile 
                165                 170                 175     


Pro Asp Glu Asn Pro Ser Ser Phe Ser Gly Ser Leu Ile Arg His Leu 
            180                 185                 190         


Gln Val Ser His Thr Leu Phe Tyr Asp Asp Phe Ile Asp Phe Asn Ile 
        195                 200                 205             


Ile Glu Glu Ala Leu Ile Arg Arg Val Leu Asp Arg Ser Leu Leu Glu 
    210                 215                 220                 


Tyr Val Asn His Ser Asn Thr Thr 
225                 230         


<210>  397
<211>  2104
<212>  DNA
<213>  Homo Sapiens

<400>  397
tacctccagg agggctgctc tgcccttcct tcctctgttc tttggcctta tgttccccgc       60

caccacagac cttcccccgc cccacccctc tgcagactta gccgtgcatt gcaggcatgg      120

aggattaatc agtgacagga agctgcgtct ctcggagcgg tgaccagctg tggtcaggag      180

agcctcagca gggccagccc caggagtctt tcccgattct tgctcactgc tcacccacct      240

gctgctgcca tgaggcacct tggggccttc ctcttccttc tgggggtcct gggggccctc      300

actgagatgt gtgaaatacc agagatggac agccatctgg tagagaagtt gggccagcac      360

ctcttacctt ggatggaccg gctttccctg gagcacttga accccagcat ctatgtgggc      420

ctacgcctct ccagtctgca ggctgggacc aaggaagacc tctacctgca cagcctcaag      480

cttggttacc agcagtgcct cctagggtct gccttcagcg aggatgacgg tgactgccag      540

ggcaagcctt ccatgggcca gctggccctc tacctgctcg ctctcagagc caactgtgag      600

tttgtcaggg gccacaaggg ggacaggctg gtctcacagc tcaaatggtt cctggaggat      660

gagaagagag ccattgggca tgatcacaag ggccaccccc acactagcta ctaccagtat      720

ggcctgggca ttctggccct gtgtctccac cagaagcggg tccatgacag cgtggtggac      780

aaacttctgt atgctgtgga acctttccac cagggccacc attctgtgga cacagcagcc      840

atggcaggct tggcattcac ctgtctgaag cgctcaaact tcaaccctgg tcggagacaa      900

cggatcacca tggccatcag aacagtgcga gaggagatct tgaaggccca gacccccgag      960

ggccactttg ggaatgtcta cagcacccca ttggcattac agttcctcat gacttccccc     1020

atgcgtgggg cagaactggg aacagcatgt ctcaaggcga gggttgcttt gctggccagt     1080

ctgcaggatg gagccttcca gaatgctctc atgatttccc agctgctgcc cgttctgaac     1140

cacaagacct acattgatct gatcttccca gactgtctgg caccacgagt catgttggaa     1200

ccagctgctg agaccattcc tcagacccaa gagatcatca gtgtcacgct gcaggtgctt     1260

agtctcttgc cgccgtacag acagtccatc tctgttctgg ccgggtccac cgtggaagat     1320

gtcctgaaga aggcccatga gttaggagga ttcacatatg aaacacaggc ctccttgtca     1380

ggcccctact taacctccgt gatggggaaa gcggccggag aaagggagtt ctggcagctt     1440

ctccgagacc ccaacacccc actgttgcaa ggtattgctg actacagacc caaggatgga     1500

gaaaccattg agctgaggct ggttagctgg tagcccctga gctccctcat cccagcagcc     1560

tcgcacactc cctaggcttc taccctccct cctgatgtcc ctggaacagg aactcgcctg     1620

accctgctgc cacctcctgt gcactttgag caatgccccc tgggatcacc ccagccacaa     1680

gcccttcgag ggccctatac catggcccac cttggagcag agagccaagc atcttccctg     1740

ggaagtcttt ctggccaagt ctggccagcc tggccctgca ggtctcccat gaaggccacc     1800

ccatggtctg atgggcatga agcatctcag actccttggc aaaaaacgga gtccgcaggc     1860

cgcaggtgtt gtgaagacca ctcgttctgt ggttggggtc ctgcaagaag gcctcctcag     1920

cccgggggct atggccctga ccccagctct ccactctgct gttagagtgg cagctccgag     1980

ctggttgtgg cacagtagct ggggagacct cagcagggct gctcagtgcc tgcctctgac     2040

aaaattaaag cattgatggc ctgtggacct gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaa                                                                  2104


<210>  398
<211>  427
<212>  PRT
<213>  Homo Sapiens

<400>  398

Met Arg His Leu Gly Ala Phe Leu Phe Leu Leu Gly Val Leu Gly Ala 
1               5                   10                  15      


Leu Thr Glu Met Cys Glu Ile Pro Glu Met Asp Ser His Leu Val Glu 
            20                  25                  30          


Lys Leu Gly Gln His Leu Leu Pro Trp Met Asp Arg Leu Ser Leu Glu 
        35                  40                  45              


His Leu Asn Pro Ser Ile Tyr Val Gly Leu Arg Leu Ser Ser Leu Gln 
    50                  55                  60                  


Ala Gly Thr Lys Glu Asp Leu Tyr Leu His Ser Leu Lys Leu Gly Tyr 
65                  70                  75                  80  


Gln Gln Cys Leu Leu Gly Ser Ala Phe Ser Glu Asp Asp Gly Asp Cys 
                85                  90                  95      


Gln Gly Lys Pro Ser Met Gly Gln Leu Ala Leu Tyr Leu Leu Ala Leu 
            100                 105                 110         


Arg Ala Asn Cys Glu Phe Val Arg Gly His Lys Gly Asp Arg Leu Val 
        115                 120                 125             


Ser Gln Leu Lys Trp Phe Leu Glu Asp Glu Lys Arg Ala Ile Gly His 
    130                 135                 140                 


Asp His Lys Gly His Pro His Thr Ser Tyr Tyr Gln Tyr Gly Leu Gly 
145                 150                 155                 160 


Ile Leu Ala Leu Cys Leu His Gln Lys Arg Val His Asp Ser Val Val 
                165                 170                 175     


Asp Lys Leu Leu Tyr Ala Val Glu Pro Phe His Gln Gly His His Ser 
            180                 185                 190         


Val Asp Thr Ala Ala Met Ala Gly Leu Ala Phe Thr Cys Leu Lys Arg 
        195                 200                 205             


Ser Asn Phe Asn Pro Gly Arg Arg Gln Arg Ile Thr Met Ala Ile Arg 
    210                 215                 220                 


Thr Val Arg Glu Glu Ile Leu Lys Ala Gln Thr Pro Glu Gly His Phe 
225                 230                 235                 240 


Gly Asn Val Tyr Ser Thr Pro Leu Ala Leu Gln Phe Leu Met Thr Ser 
                245                 250                 255     


Pro Met Arg Gly Ala Glu Leu Gly Thr Ala Cys Leu Lys Ala Arg Val 
            260                 265                 270         


Ala Leu Leu Ala Ser Leu Gln Asp Gly Ala Phe Gln Asn Ala Leu Met 
        275                 280                 285             


Ile Ser Gln Leu Leu Pro Val Leu Asn His Lys Thr Tyr Ile Asp Leu 
    290                 295                 300                 


Ile Phe Pro Asp Cys Leu Ala Pro Arg Val Met Leu Glu Pro Ala Ala 
305                 310                 315                 320 


Glu Thr Ile Pro Gln Thr Gln Glu Ile Ile Ser Val Thr Leu Gln Val 
                325                 330                 335     


Leu Ser Leu Leu Pro Pro Tyr Arg Gln Ser Ile Ser Val Leu Ala Gly 
            340                 345                 350         


Ser Thr Val Glu Asp Val Leu Lys Lys Ala His Glu Leu Gly Gly Phe 
        355                 360                 365             


Thr Tyr Glu Thr Gln Ala Ser Leu Ser Gly Pro Tyr Leu Thr Ser Val 
    370                 375                 380                 


Met Gly Lys Ala Ala Gly Glu Arg Glu Phe Trp Gln Leu Leu Arg Asp 
385                 390                 395                 400 


Pro Asn Thr Pro Leu Leu Gln Gly Ile Ala Asp Tyr Arg Pro Lys Asp 
                405                 410                 415     


Gly Glu Thr Ile Glu Leu Arg Leu Val Ser Trp 
            420                 425         


<210>  399
<211>  4088
<212>  DNA
<213>  Homo Sapiens

<400>  399
cacttcgcct caagcgctgg agtcgaccag aactctgcgg ctcggctgcc ggcaagaccc       60

ggatagcgga tttcgctcct ggctgcgggg cgcgcactcg cccgcccgcc cgctcgctcg      120

ttcctcgcgc gggcactggg catgcgcggc gcgcggttgg cactggctgc gagcgggcgg      180

gcggctccag acttcacagg cagcagctag cgaggcggtc tcgcccggcg cgaggccggc      240

gctgtgctcg cctcggagat cgctgctctt tagctgggtg cagaaggcgg ctccgcggct      300

cgcggacgac tggctgggcg cgaatcagat tggggggctt tctcccggtc ccctcccacc      360

tcgtctgggc tcgcggcgtc tccggggaaa gccgtggccc cgagggcgga tccgagaaca      420

cacaagtgaa agacacaatg aatggtcata tttctaatca tcccagtagt tttggaatgt      480

acccatctca gatgaatggc tacggatcat cacctacctt ttcccagacg gacagagaac      540

atggttcaaa aacaagtgca aaggcccttt atgaacaaag gaagaattat gcacgggaca      600

gtgtcagcag tgtgtcagat atatctcaat accgtgttga acacttgact acctttgtcc      660

tggatcggaa agatgctatg atcactgttg atgatggaat aaggaaattg aaattgcttg      720

atgccaaggg caaagtgtgg actcaagata tgattcttca agtggatgac agagctgtga      780

gcctgattga tttagaatca aagaatgaac tggagaattt tcctttaaac acaatccagc      840

actgccaagc tgtgatgcat tcatgcagct atgattcagt tcttgcactg gtgtgcaaag      900

agccaaccca gaacaagcca gatcttcatc tcttccagtg tgatgaggtt aaggcaaacc      960

taattagtga agatattgaa agtgcaatca gtgacagtaa aggagggaaa cagaagaggc     1020

ggcccgacgc cctgaggatg atttccaatg cagaccctag tataccgcct ccacccagag     1080

ctcctgcccc tgcgccccct gggaccgtca cccaggtgga tgttagaagt cgagtggcag     1140

cctggtctgc atgggcagcc gaccaagggg actttgagaa accaaggcag tatcatgagc     1200

aggaagaaac acctgagatg atggcagccc gcattgacag agatgtgcaa atcttaaacc     1260

acattttgga tgacattgaa ttttttatca caaaactcca aaaagcagca gaagcatttt     1320

ctgagctttc taaaaggaag aaaaacaaga aaggtaaaag gaaaggacca ggagagggtg     1380

ttttaacgct gcgggcaaaa cctccacctc ctgatgaatt tcttgactgt ttccaaaagt     1440

ttaaacacgg atttaacctt ctggccaaac tgaagtctca tattcagaat cctagtgctg     1500

cagatttggt tcactttttg tttactccat taaatatggt ggtgcaggca acaggaggtc     1560

ctgaactagc cagttcagta cttagtcccc tattgaataa ggacacaatt gatttcttaa     1620

attatactgt caatggtgat gaacggcagc tgtggatgtc attgggagga acttggatga     1680

aagccagagc agagtggcca aaagaacagt ttattccacc atatgttcca cgattccgca     1740

atggctggga gcccccaatg ctgaacttta tgggagccac aatggaacaa gatctttatc     1800

aactggcaga atctgtggca aatgtagcag aacatcagcg caaacaggaa ataaaaagat     1860

tatccacaga gcattccagt gtatcagagt atcatccagc cgatggctat gcgttcagta     1920

gcaacattta cacaagagga tcccacctgg accaagggga agctgctgtt gcttttaagc     1980

caacttctaa tcgccatata gatagaaatt atgaaccact caaaacacaa cccaagaaat     2040

atgccaaatc caagtatgac tttgtagcaa ggaacaacag tgagctctcg gttctaaagg     2100

atgatatttt agagatactt gatgatcgga agcaatggtg gaaagttcga aatgcaagtg     2160

gagactctgg atttgtgcca aataacattt tggatattgt gagacctcca gaatctggat     2220

tggggcgtgc tgatccacct tatactcata ctatacagaa acaaaggatg gagtatggcc     2280

caagaccagc tgatactccc cctgctccat cacctcctcc aacaccagct cctgttcctg     2340

ttccccttcc cccttccact ccagcacctg ttcctgtgtc aaaggtccca gcaaatataa     2400

cacgtcaaaa cagcagctcc agtgacagtg gtggcagtat cgtgcgagac agccagagac     2460

acaaacaact tccggtggac cgaaggaaat ctcagatgga ggaagtgcaa gatgaactca     2520

tccacagact gaccattggt cggagtgccg ctcagaagaa attccatgtg ccacggcaga     2580

acgtgccagt tatcaatatc acttacgact ccacaccaga ggatgtgaag acgtggttac     2640

agtcaaaggg attcaaccct gtgactgtca atagtcttgg agtattaaat ggtgcacaac     2700

ttttctctct caataaggat gaactgagga cagtctgccc tgaaggggcg agagtctata     2760

gccaaatcac tgtacaaaaa gctgcattgg aggatagcag tggcagctcc gagttacaag     2820

aaattatgag aagacgacag gaaaaaatca gtgctgccgc tagtgattca ggagtggaat     2880

cttttgatga aggaagcagt cactaatttg tttgtttgta tttaaactcc attgtttttg     2940

gcattattcc aacatgcttt gttttaagaa gccttgaagg gaatgtcaga ttcatttttc     3000

ttgatgtaat ttatcaccat aaaaaaaaaa cccatgcaaa cctgagtgag cacaggattt     3060

gcttctaggc ccattatttt tattaaaact gaaaaaattt aaactgaatt ttttgacctt     3120

ggaaaatatt tttcttactt taccaaggtg aagtttcctt aattagacta attattttat     3180

ccccatccca gggtataaac aggaattgtt ttgatagtgg tggagttatt cactgcaaca     3240

aagcaacaat gttgtccatg attcaaaatc taagcagttt cgattttgcc tgtgaatatg     3300

gtgtctgtca ttcagggcat agctcactgt aggctagcct ctgcttactt aagtctcttc     3360

tctgacatac tcaatggaag aatatttaga tttatttaaa gttcttaatg ccaacagttt     3420

aaaaaaaaat taaaacattt gaatgaactg taaagtacag ccataccttg gacatgcaaa     3480

tataaatcta tggagcattc tcaagacagt ttgtcatggc tctgttgatt gcaactcctt     3540

gtatagcttg tattttgatt tagtttatat tctgcttatt atgtatactg tgttcttata     3600

tatgagaaag cacaaatgcg aaagaggtca tgtcttctca aaatctagca aaggaagtag     3660

tctgcattgg tgtgcattac agtattttgc ttaatgaaag cctcagttct gaatgttgat     3720

atgagtagtt aaaaggaagt ggggccattt tatgtgttta tctgtgtcaa gtatttctgg     3780

taataagaag cacttaattt acacatattt taatcctgtg aaagattcca catagagaaa     3840

agaaagatac ctaaccttca acaaatgtta tttttggaaa cacaattttt gtcattaaat     3900

gttatattat ttcacatata taaaacagat gttatgtaag aatgttgtat attttaacat     3960

aaatcattta gagaaattat ctagattcat taattttcat agtgcctttt tcacatgagt     4020

cagctggaaa gtctgcaata aacagtattt gctgtctgtt aataaatggt ttctgtctca     4080

ttaaaaaa                                                              4088


<210>  400
<211>  822
<212>  PRT
<213>  Homo Sapiens

<400>  400

Met Asn Gly His Ile Ser Asn His Pro Ser Ser Phe Gly Met Tyr Pro 
1               5                   10                  15      


Ser Gln Met Asn Gly Tyr Gly Ser Ser Pro Thr Phe Ser Gln Thr Asp 
            20                  25                  30          


Arg Glu His Gly Ser Lys Thr Ser Ala Lys Ala Leu Tyr Glu Gln Arg 
        35                  40                  45              


Lys Asn Tyr Ala Arg Asp Ser Val Ser Ser Val Ser Asp Ile Ser Gln 
    50                  55                  60                  


Tyr Arg Val Glu His Leu Thr Thr Phe Val Leu Asp Arg Lys Asp Ala 
65                  70                  75                  80  


Met Ile Thr Val Asp Asp Gly Ile Arg Lys Leu Lys Leu Leu Asp Ala 
                85                  90                  95      


Lys Gly Lys Val Trp Thr Gln Asp Met Ile Leu Gln Val Asp Asp Arg 
            100                 105                 110         


Ala Val Ser Leu Ile Asp Leu Glu Ser Lys Asn Glu Leu Glu Asn Phe 
        115                 120                 125             


Pro Leu Asn Thr Ile Gln His Cys Gln Ala Val Met His Ser Cys Ser 
    130                 135                 140                 


Tyr Asp Ser Val Leu Ala Leu Val Cys Lys Glu Pro Thr Gln Asn Lys 
145                 150                 155                 160 


Pro Asp Leu His Leu Phe Gln Cys Asp Glu Val Lys Ala Asn Leu Ile 
                165                 170                 175     


Ser Glu Asp Ile Glu Ser Ala Ile Ser Asp Ser Lys Gly Gly Lys Gln 
            180                 185                 190         


Lys Arg Arg Pro Asp Ala Leu Arg Met Ile Ser Asn Ala Asp Pro Ser 
        195                 200                 205             


Ile Pro Pro Pro Pro Arg Ala Pro Ala Pro Ala Pro Pro Gly Thr Val 
    210                 215                 220                 


Thr Gln Val Asp Val Arg Ser Arg Val Ala Ala Trp Ser Ala Trp Ala 
225                 230                 235                 240 


Ala Asp Gln Gly Asp Phe Glu Lys Pro Arg Gln Tyr His Glu Gln Glu 
                245                 250                 255     


Glu Thr Pro Glu Met Met Ala Ala Arg Ile Asp Arg Asp Val Gln Ile 
            260                 265                 270         


Leu Asn His Ile Leu Asp Asp Ile Glu Phe Phe Ile Thr Lys Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Ala Phe Ser Glu Leu Ser Lys Arg Lys Lys Asn Lys 
    290                 295                 300                 


Lys Gly Lys Arg Lys Gly Pro Gly Glu Gly Val Leu Thr Leu Arg Ala 
305                 310                 315                 320 


Lys Pro Pro Pro Pro Asp Glu Phe Leu Asp Cys Phe Gln Lys Phe Lys 
                325                 330                 335     


His Gly Phe Asn Leu Leu Ala Lys Leu Lys Ser His Ile Gln Asn Pro 
            340                 345                 350         


Ser Ala Ala Asp Leu Val His Phe Leu Phe Thr Pro Leu Asn Met Val 
        355                 360                 365             


Val Gln Ala Thr Gly Gly Pro Glu Leu Ala Ser Ser Val Leu Ser Pro 
    370                 375                 380                 


Leu Leu Asn Lys Asp Thr Ile Asp Phe Leu Asn Tyr Thr Val Asn Gly 
385                 390                 395                 400 


Asp Glu Arg Gln Leu Trp Met Ser Leu Gly Gly Thr Trp Met Lys Ala 
                405                 410                 415     


Arg Ala Glu Trp Pro Lys Glu Gln Phe Ile Pro Pro Tyr Val Pro Arg 
            420                 425                 430         


Phe Arg Asn Gly Trp Glu Pro Pro Met Leu Asn Phe Met Gly Ala Thr 
        435                 440                 445             


Met Glu Gln Asp Leu Tyr Gln Leu Ala Glu Ser Val Ala Asn Val Ala 
    450                 455                 460                 


Glu His Gln Arg Lys Gln Glu Ile Lys Arg Leu Ser Thr Glu His Ser 
465                 470                 475                 480 


Ser Val Ser Glu Tyr His Pro Ala Asp Gly Tyr Ala Phe Ser Ser Asn 
                485                 490                 495     


Ile Tyr Thr Arg Gly Ser His Leu Asp Gln Gly Glu Ala Ala Val Ala 
            500                 505                 510         


Phe Lys Pro Thr Ser Asn Arg His Ile Asp Arg Asn Tyr Glu Pro Leu 
        515                 520                 525             


Lys Thr Gln Pro Lys Lys Tyr Ala Lys Ser Lys Tyr Asp Phe Val Ala 
    530                 535                 540                 


Arg Asn Asn Ser Glu Leu Ser Val Leu Lys Asp Asp Ile Leu Glu Ile 
545                 550                 555                 560 


Leu Asp Asp Arg Lys Gln Trp Trp Lys Val Arg Asn Ala Ser Gly Asp 
                565                 570                 575     


Ser Gly Phe Val Pro Asn Asn Ile Leu Asp Ile Val Arg Pro Pro Glu 
            580                 585                 590         


Ser Gly Leu Gly Arg Ala Asp Pro Pro Tyr Thr His Thr Ile Gln Lys 
        595                 600                 605             


Gln Arg Met Glu Tyr Gly Pro Arg Pro Ala Asp Thr Pro Pro Ala Pro 
    610                 615                 620                 


Ser Pro Pro Pro Thr Pro Ala Pro Val Pro Val Pro Leu Pro Pro Ser 
625                 630                 635                 640 


Thr Pro Ala Pro Val Pro Val Ser Lys Val Pro Ala Asn Ile Thr Arg 
                645                 650                 655     


Gln Asn Ser Ser Ser Ser Asp Ser Gly Gly Ser Ile Val Arg Asp Ser 
            660                 665                 670         


Gln Arg His Lys Gln Leu Pro Val Asp Arg Arg Lys Ser Gln Met Glu 
        675                 680                 685             


Glu Val Gln Asp Glu Leu Ile His Arg Leu Thr Ile Gly Arg Ser Ala 
    690                 695                 700                 


Ala Gln Lys Lys Phe His Val Pro Arg Gln Asn Val Pro Val Ile Asn 
705                 710                 715                 720 


Ile Thr Tyr Asp Ser Thr Pro Glu Asp Val Lys Thr Trp Leu Gln Ser 
                725                 730                 735     


Lys Gly Phe Asn Pro Val Thr Val Asn Ser Leu Gly Val Leu Asn Gly 
            740                 745                 750         


Ala Gln Leu Phe Ser Leu Asn Lys Asp Glu Leu Arg Thr Val Cys Pro 
        755                 760                 765             


Glu Gly Ala Arg Val Tyr Ser Gln Ile Thr Val Gln Lys Ala Ala Leu 
    770                 775                 780                 


Glu Asp Ser Ser Gly Ser Ser Glu Leu Gln Glu Ile Met Arg Arg Arg 
785                 790                 795                 800 


Gln Glu Lys Ile Ser Ala Ala Ala Ser Asp Ser Gly Val Glu Ser Phe 
                805                 810                 815     


Asp Glu Gly Ser Ser His 
            820         


<210>  401
<211>  8245
<212>  DNA
<213>  Homo Sapiens

<400>  401
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga       60

aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca      120

aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg      180

agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg      240

gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt      300

tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct      360

ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca      420

ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa      480

accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac      540

atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga      600

gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac      660

agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga      720

catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt      780

tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga      840

tgctgcctca aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc      900

agagtccaga atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc      960

agtgaacaca gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca     1020

ggacagtaaa cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggctgaa     1080

ttctccctct ggaaactgag ttacaaccac caatactggc aggttccctg gatccagatc     1140

ttctctgccc aactcttact gggagattgc aaactgccac atctcagcct gtaagcaaag     1200

caggaaacct tctgctgggc atagcttgtg cctaaatgga caaatggatg catacccttc     1260

ctgaaatgac tcccttctga atgaatgaca aagcaggtta cctagtatag ttttcccaaa     1320

cttcttccca tcatagcaca tgtagaaaat aatattttta tggcacactg ggataaacaa     1380

gcaagattgc tcacttctgg aagctgcata tgactagagg cctcttgtga ctggaggtaa     1440

caaccctgcc cagtaactgt gggagaaggg gatcaatatt ttgcacacct gtaataggcc     1500

atggcacacc agccaagatg ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt     1560

ggccttcacc acgcatcttg agcaaattag gaaaatgtac ccttcgcttg aggcagatgc     1620

agcccttccc ccgagtgcat ggcttggaga gcagaatgtg ggctgcatat aagcacactc     1680

atccctttgt ctgggaatct ttgtgcaggg cataacaggc ttagtaagtc caaacacaga     1740

tgacagtgct gtgtgggtct ctgtcagagt tgtggctctc agccatgtag acacactctc     1800

caaatggagt gttggaaaat gttctttctg cagggtctag agactgctgg gacacttttc     1860

ttggagtgct acttcagaag ccttatagga ttttctttct ggccaagatt tccttctgta     1920

tcactccaag cagcctcagc agaagaagca gccatgccca gtattcccac tctccaaaag     1980

gaactgacca gcttatattt ctcacacttc tggggaactg ggtataatcc aaccatcaaa     2040

atagaagacc ttgcaagaag cagagtcatt ctccagaagg aacttgggag atgatggtgc     2100

agatgatgaa actgggttca tcccagttcc aaagactcag agaactagag tttaagctga     2160

ggcagagtgc cgccaccctg gcatgcccca caaacagatc accagccagc ttacacaggc     2220

attaactctc ctcaatgagg aagaatcatt cacaactgag caagacattc atatgatcat     2280

ttaaggaagt gtttccctta tgtgttagca agtataatcg gctaactcct aaatcccaat     2340

gaatagtcct aggctggaca gcaatgggct gcaattaggc agataaagac atcagtccca     2400

gtaaatgaat ccatagactc atctagcacc aactaccatt agcactatgt taggagctgc     2460

aaggccccaa agtagaagat gtgcataatg tctgctcttg tgtagctcag gagacaattc     2520

cagcacagac actacagtta acgctgaact gcagctgcaa gtaatagcat gaacagtcag     2580

aaaaatacct tatgaggggg cagggctgaa gctgggcctt gaaggatgga tgaaatttgg     2640

atagagaatg aggaagacag agggcctcca agtgagagaa gcatgaaaaa tgagcagggg     2700

cctggatcag tggggtgtat tcagagcacc tctccagatg caccatgcat gctcacagtc     2760

ccttgcctat gtgtggcaga gtgtcccagc cagatgtgtg ccctcacccc atgtccattt     2820

acatgtcctt caatgcccac ctcaaaaggt acctcttctg taaagctttc cctggtatca     2880

ggaatcaaaa ttaatcaggg atcttttcac actgctgttt tttcctcttt ggtccttcta     2940

tcactaaaac tcatctcatt cagccttaca gcataactaa ttatttgttt tcctcactac     3000

attgtacatg tgggaattac agataaacgg aagccggctg gggtggtggc tcacgcctgt     3060

aatcccaaca ctttgggagg ccaaggcagg cggatcacct gaggtcagga gttcgagatt     3120

agtctggcca acatggtgaa accccatctc tactaaaaat acgaaattag ccaggtgtgg     3180

tggcacacat ctgtagtccc agctactctg gaggctgaga caggagaatc gcttgaaccc     3240

aggaagtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggagagaca     3300

gagtgagact ccatctcgaa aaaaaaaaaa agatagaagc caataagcat ggtgcaatca     3360

aattctggca agcattaaat atcaggatgc agctgggcac ggtggctcac gcctgtaatc     3420

ccagcacttt gggaggccaa ggtgggcgga tcacttgagg tcaggaattt gagaggatcc     3480

tggccagcat ggcaaaaccc catctgtact taaaatacaa aaaaattagc tgggcgtggt     3540

ggtgcacacc tgtaatccca gctacttggg aggctgaggt gggagaattg cttgaacctg     3600

ggaggtggag gttgcagtga gctgagatcc tgccactgca ctccaggctg ggcaacagag     3660

tgagaccatg tctcaaaaaa taaaaataaa ataaaataat atcaggatgc atacatcaga     3720

ggctgttcct agtgtaaagg cactttggag ggagaagact ttcagagtta ggcagaccaa     3780

ctaagaggtc agctgaagca cctaaccagt tgtaaggagg tgaaagacag caccccaaga     3840

agagacgtgc aggaaggagg aaagaggctt ggtcataaag gatggaggaa ttccaaagtg     3900

acactgaaca ggctgcgttt atcctaaaat aaaaccactc ctcactctgt ggatgcgttg     3960

aagactcatt cccaaacatc tttattctct aacttgccct cttcctcttc ctaatatgct     4020

cactcaagta aaattactag tgtcctaatg cccctatgca tattgtcaaa aataaaaatc     4080

agaagcaggt tagatctgtt aggtcttcca gaagagcaaa cctgggatga agccagagcc     4140

caggaattct gaaggtagcc tttggactca ggacacccta ctcttgtctc tcctctcagt     4200

ttctctgcta tgaatctcct gattcatgaa cacgttatct gttcaccctt ctctctaggt     4260

cttagttctt agattttcct tctgtaaaat gcatgtgatc ttattttccc ctccacaact     4320

ttccagatga actagactgt gaccaagagg tctataaaat caaagcatca tggaacagga     4380

tcttgtatca gaccaaagtg tgccagtttt taaaaatgtg catcaaaatg gaagtctcag     4440

agacagagcc ctctggtgga aagttctagt aggttaggac agtcctgcct gcagacacct     4500

tgggctttac tgagggactc aactgagaaa atgaggaatg ttgcagctca tgattcttag     4560

aagaagaaag tgaagcttgt ttaaaatatg atttaaaaaa tctgtagaac actgtaaact     4620

acacaggcta tgagggaata gcctggttgg gccagcttgg aaatcgggca caggcaggaa     4680

ggggcctgtc tggtttgggc cgtgtccaca gagagcactt cttaggtcct gcctggagag     4740

aaggaatggc tgggctatat tttcttccag actcattatt tttcttctgt ttgacttttc     4800

tctgaatttc ccttgatttg tataaatttt ctcaataatt agtgacagtg tctactgatt     4860

gtaaaatgaa gcttgaaggc caggcgcagt ggctcatgcc tgtaatccta gaattttggg     4920

aggccaaggt gggtggatca caaggagttc gagaccagcc tggccaaggt tgtgaaaccg     4980

cgtctctact aaaaatacaa aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca     5040

gctactcagg aagctgaggc aacagaatca cttgaacctg ggaggtggag gttgcagtga     5100

gccgagatca cgccactgca ctccagcctg ggcgagagag tgagactccg tctcaaaaaa     5160

aaaaaaaaaa aaaaaagttt gaagaacaaa gacaataaga ggaaatataa tgagtggtca     5220

taaatgtggg ctctgacagt agagtgcctg ggtctgcatc ctggtttctt agtcatgtga     5280

ccttaggcaa gttactttaa cctcgctgta cctcaggttg tccatctgta aaatggggat     5340

aataatagtg cctacctttt aaggttgatg tggggattaa atgaggtgtt gctcatacag     5400

gaatgtgcct gtgcatggca aagttcggga aattttttat aagctgttct aggcctgaaa     5460

tcttcagaag atgctaatct aaattcatga aataagcttc ttacaacaga aatgctgcta     5520

gtattatgca aaattaatgt tgtatatcaa acttttaact ctcatccctc cttattcaga     5580

tatattttgt tataagcaat gtttgttccc ctcgttatta taccacagtc tacttacctg     5640

atgctatatc tgcctcccca gttagactga gagaacaggg gatataccta aataataata     5700

ataataataa taataataaa taataatgga gagctccttg aagataggga gcctgtaaga     5760

atcattgagg gcttattttg tataccaact gctaaactag atgcttcata cattgttgtc     5820

aatactcatg acagccttgt aaagtagaaa ttaattcttc cagttaacac taaggctgac     5880

atatgaatac cttggcaaat ctggaaagct gggaagacag tatttgaatt caagacttct     5940

tgtcaccaag ggccatgcac ttgtactctg ccatgtggcc cttttttacc tcctgtggat     6000

tctccctacc tggtacttgg ccttaggtgt acacacacct ggcactttgc ttgacacata     6060

ataggtggac cacaaatatc tactaaatga atatttgcat atagtaatat tttaaggtac     6120

taaaagcagc tcaaagtaaa tatattaata tattaattcc attgctatct ggataaccac     6180

tcaactttcc tgctgaaaat gcccatttaa ttaaagaagg ttggatagag ctctctatat     6240

gcattttgga caggcagggg tttcaggtca taaacattct gatgagttaa tataaaataa     6300

gagaaactgt aaatttccac tactaaaaat cacaaaaata acagaaacaa aagaagagat     6360

aagaatttgg ggaattgtgc tgaacaattt agtggttaaa aaaaacaact gtgcatgttt     6420

agacttaaat aagcccccat ccaagtgtga ggggtccagt aatttttcaa aacatatgaa     6480

agtgttaata catttcgaca aaggaccatt aaaaaagtcc tgaattctga cttgagggag     6540

gaaagtaatg actaatacat tctctagaga cttgcagact ttgggaattc ataaaggaat     6600

ggatgataat tattaactgt tgctggctga ttgcccagac agttctcaac agccctgtac     6660

aagtctctgg gtttgggatg gatcaattct gagactggaa aatggccaaa tctttgcaaa     6720

tgagaaatat ttttcttata agttcttatt gtaggcaaat aattacatag attattcatc     6780

agagaatttt taaatgctca taatctcaac tctttcattt acaacttgta tttccaatag     6840

tttatgggtc atctctgcat agatgtcaga agtcacctca agtttagcgt gtccaaaatc     6900

taactcacag gtctgtttct gacctcccaa cttgctttcc ttgtgttttt cctatgctaa     6960

tgatccacca taatcaaaat aattaacatt tatccagtgc ctactatgta ctattccctg     7020

tcctgtttta catttactca tttaaagtcc ataagaaaca ttaaatctca tctgccttct     7080

gaagaagata caaccatgct ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa     7140

gtctttaagg ctgaatcaca gtagctcatc ctagtaaata gaaaagccag gattcaactc     7200

caggggctgg gtgcagaact gctattcttc actgcttcac caatcagcag ctacccaagg     7260

cagaaaactt tttcatcctt ggctccttca ttctccctgt caccccagat cccctctaca     7320

tctagtcaga gaataggtcc tgtcaattcc aacttctcta tatggctcct ctcaggcatg     7380

tgcccttaat tggcctaatt ctctaataca ccttccctct acatgctcac tccctcagat     7440

cattgcttta tcacgtgtta cctgggttgc tattacataa agagcaatct ttctaaaatg     7500

aggatcttat cacttcactt ccacactaaa atgtttttcc tggggaacca cactccttag     7560

caatctgacc catcagacct tccaggctgt ctcctgcctg ctccctaagg ctccagccac     7620

acagaattat catgggccca cacacccacc aaatcctccc atgcctttgc ccatgttgtc     7680

tgggatgccc ttctctccct tctgtctaca tcaagcatca gactgaatat ccctcttgtg     7740

cggccttcta aaacctcccg tccaaagcga aatatattgc cctctattta tacttttaca     7800

gcatttggca cacaagtaca gagtagtagc tttttatcac attctctgat aattatatag     7860

atatggtatt tcttagctct ctctccaact ggctaataag ttgctttttg tctgagtgcc     7920

taattttgtg ttttgtgtct gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt     7980

cattattcat ttgaacatgg aaattatgct cactagtggc aaatgccact aaccgtattc     8040

cagaagctag gtgtcatgtt tgcaataaga tatattatcc cttctacaag tcacctttta     8100

tttcaggcat ttgtaaatgc ccattaataa agtatggttc ataaatttta ccttgtaagt     8160

gcctaagaaa tgagactaca agctccattt cagcaggaca caataaatat tattttataa     8220

tgcatctaaa aaaaaaaaaa aaaaa                                           8245


<210>  402
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  402

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 
                245                 250                 255     


Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 
            260                 265                 270         


Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 
        275                 280                 285             


Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 
    290                 295                 300                 


Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 
305                 310                 315                 320 


Thr Ser Ser Tyr Glu Ile Val Ile 
                325             


<210>  403
<211>  3863
<212>  DNA
<213>  Homo Sapiens

<400>  403
atttaagagc caactgtctt gtctttcccg agtccgtttg aggaagtccc cgaggcgcac       60

agagcaagcc cacgcgaggg cacctctgga ggggagcgcc tgcaggacct tgtaaagtca      120

aaaatgtcag aaacttccag gaccgccttt ggaggcagaa gagcagttcc acccaataac      180

tctaatgcag cggaagatga cctgcccaca gtggagcttc agggcgtggt gccccggggc      240

gtcaacctgc aagagtttct taatgtcacg agcgttcacc tgttcaagga gagatgggac      300

actaacaagg tggaccacca cactgacaag tatgaaaaca acaagctgat tgtccgcaga      360

gggcagtctt tctatgtgca gattgacttc agtcgtccat atgaccccag aagggatctc      420

ttcagggtgg aatacgtcat tggtcgctac ccacaggaga acaagggaac ctacatccca      480

gtgcctatag tctcagagtt acaaagtgga aagtgggggg ccaagattgt catgagagag      540

gacaggtctg tgcggctgtc catccagtct tcccccaaat gtattgtggg gaaattccgc      600

atgtatgttg ctgtctggac tccctatggc gtacttcgaa ccagtcgaaa cccagaaaca      660

gacacgtaca ttctcttcaa tccttggtgt gaagatgatg ctgtgtatct ggacaatgag      720

aaagaaagag aagagtatgt cctgaatgac atcggggtaa ttttttatgg agaggtcaat      780

gacatcaaga ccagaagctg gagctatggt cagtttgaag atggcatcct ggacacttgc      840

ctgtatgtga tggacagagc acaaatggac ctctctggaa gagggaatcc catcaaagtc      900

agccgtgtgg ggtctgcaat ggtgaatgcc aaagatgacg aaggtgtcct cgttggatcc      960

tgggacaata tctatgccta tggcgtcccc ccatcggcct ggactggaag cgttgacatt     1020

ctattggaat accggagctc tgagaatcca gtccggtatg gccaatgctg ggtttttgct     1080

ggtgtcttta acacattttt acgatgcctt ggaataccag caagaattgt taccaattat     1140

ttctctgccc atgataatga tgccaatttg caaatggaca tcttcctgga agaagatggg     1200

aacgtgaatt ccaaactcac caaggattca gtgtggaact accactgctg gaatgaagca     1260

tggatgacaa ggcctgacct tcctgttgga tttggaggct ggcaagctgt ggacagcacc     1320

ccccaggaaa atagcgatgg catgtatcgg tgtggccccg cctcggttca agccatcaag     1380

cacggccatg tctgcttcca atttgatgca ccttttgttt ttgcagaggt caacagcgac     1440

ctcatttaca ttacagctaa gaaagatggc actcatgtgg tggaaaatgt ggatgccacc     1500

cacattggga aattaattgt gaccaaacaa attggaggag atggcatgat ggatattact     1560

gatacttaca aattccaaga aggtcaagaa gaagagagat tggccctaga aactgccctg     1620

atgtacggag ctaaaaagcc cctcaacaca gaaggtgtca tgaaatcaag gtccaacgtt     1680

gacatggact ttgaagtgga aaatgctgtg ctgggaaaag acttcaagct ctccatcacc     1740

ttccggaaca acagccacaa ccgttacacc atcacagctt atctctcagc caacatcacc     1800

ttctacaccg gggtcccgaa ggcagaattc aagaaggaga cgttcgacgt gacgctggag     1860

cccttgtcct tcaagaaaga ggcggtgctg atccaagccg gcgagtacat gggtcagctg     1920

ctggaacaag cgtccctgca cttctttgtc acagctcgca tcaatgagac cagggatgtt     1980

ctggccaagc aaaagtccac cgtgctaacc atccctgaga tcatcatcaa ggtccgtggc     2040

actcaggtag ttggttctga catgactgtg acagttgagt ttaccaatcc tttaaaagaa     2100

accctgcgaa atgtctgggt acacctggat ggtcctggag taacaagacc aatgaagaag     2160

atgttccgtg aaatccggcc caactccacc gtgcagtggg aagaagtgtg ccggccctgg     2220

gtctctgggc atcggaagct gatagccagc atgagcagtg actccctgag acatgtgtat     2280

ggcgagctgg acgtgcagat tcaaagacga ccttccatgt gaatgcacag gaagctgaga     2340

tgaaccctgg catttggcct cttgtagtct tggctaagga aattctaacg caaaaatagc     2400

tcttgctttg acttaggtgt gaagacccag acaggactgc agagggctcc agagtggaga     2460

tcccacatat ttcaaaaaca tgcttttcca aacccaggct attcggcaag gaagttagtt     2520

tttaatctct ccaccttcca aagagtgcta agcattagct ttaattaagc tctcatagct     2580

cataagagta acagtcatca tttatcatca caaatggcta catctccaaa tatcagtggg     2640

ctctcttacc agggagattt gctcaatacc tggcctcatt taaaacaaga cttcagattc     2700

cccactcagc cttttgggaa taatagcaca tgatttgggc tctagaattc cagtcccctt     2760

tctcggggtc aggttctacc ctccatgtga gaatattttt cccaggacta gagcacaaca     2820

taatttttat ttttggcaaa gccagaaaaa gatctttcat tttgcacctg cagccaagca     2880

aatgcctgcc aaattttaga tttaccttgt tagaagaggt ggccccatat taacaaattg     2940

catttgtggg aaacttaacc acctacaagg agataagaaa gcaggtgcaa cactcaagtc     3000

tattgaataa tgtagttttg tgatgcattt tatagaatgt gtcacactgt ggcctgatca     3060

gcaggagcca atatccctta ctttaaccct ttctgggatg caatactagg aagtaaagtg     3120

aagaatttat ctctttagtt agtgattata tttcacccat ctctcaggaa tcatctcctt     3180

tgcagaatga tgcaggttca ggtccccttt cagagatata ataagcccaa caagttgaag     3240

aagctggcgg atctagtgac cagatatata gaaggactgc agccactgat tctctcttgt     3300

ccttcacatc acccatgttg agacctcagc ttggcactca ggtgctgaag ggtaatatgg     3360

actcagcctt gcaaatagcc agtgctagtt ctgacccaac cacagaggat gctgacatca     3420

tttgtattat gttccaaggc tactacagag aaggctgcct gctatgtatt tgcaaggctg     3480

atttatggtc agaatttccc tctgatatgt ctagggtgtg atttaggtca gtagactgtg     3540

attcttagca aaaaatgaac agtgataagt atactggggg caaaatcaga atggaatgct     3600

ctggtctata taaccacatt tctaagcctt tgagactgtt cctgagcctt cagcactaac     3660

ctatgagggt gagctggtcc cctctatata tacatcatac ttaactttac taagtaatct     3720

cacagcattt gccaagtctc ccaatatcca attttaaaat gaaatgcatt ttgctagaca     3780

gttaaactgg cttaacttag tatattatta ttaattacaa tgtaatagaa gcttaaaata     3840

aagttaaact gattatattt gca                                             3863


<210>  404
<211>  732
<212>  PRT
<213>  Homo Sapiens

<400>  404

Met Ser Glu Thr Ser Arg Thr Ala Phe Gly Gly Arg Arg Ala Val Pro 
1               5                   10                  15      


Pro Asn Asn Ser Asn Ala Ala Glu Asp Asp Leu Pro Thr Val Glu Leu 
            20                  25                  30          


Gln Gly Val Val Pro Arg Gly Val Asn Leu Gln Glu Phe Leu Asn Val 
        35                  40                  45              


Thr Ser Val His Leu Phe Lys Glu Arg Trp Asp Thr Asn Lys Val Asp 
    50                  55                  60                  


His His Thr Asp Lys Tyr Glu Asn Asn Lys Leu Ile Val Arg Arg Gly 
65                  70                  75                  80  


Gln Ser Phe Tyr Val Gln Ile Asp Phe Ser Arg Pro Tyr Asp Pro Arg 
                85                  90                  95      


Arg Asp Leu Phe Arg Val Glu Tyr Val Ile Gly Arg Tyr Pro Gln Glu 
            100                 105                 110         


Asn Lys Gly Thr Tyr Ile Pro Val Pro Ile Val Ser Glu Leu Gln Ser 
        115                 120                 125             


Gly Lys Trp Gly Ala Lys Ile Val Met Arg Glu Asp Arg Ser Val Arg 
    130                 135                 140                 


Leu Ser Ile Gln Ser Ser Pro Lys Cys Ile Val Gly Lys Phe Arg Met 
145                 150                 155                 160 


Tyr Val Ala Val Trp Thr Pro Tyr Gly Val Leu Arg Thr Ser Arg Asn 
                165                 170                 175     


Pro Glu Thr Asp Thr Tyr Ile Leu Phe Asn Pro Trp Cys Glu Asp Asp 
            180                 185                 190         


Ala Val Tyr Leu Asp Asn Glu Lys Glu Arg Glu Glu Tyr Val Leu Asn 
        195                 200                 205             


Asp Ile Gly Val Ile Phe Tyr Gly Glu Val Asn Asp Ile Lys Thr Arg 
    210                 215                 220                 


Ser Trp Ser Tyr Gly Gln Phe Glu Asp Gly Ile Leu Asp Thr Cys Leu 
225                 230                 235                 240 


Tyr Val Met Asp Arg Ala Gln Met Asp Leu Ser Gly Arg Gly Asn Pro 
                245                 250                 255     


Ile Lys Val Ser Arg Val Gly Ser Ala Met Val Asn Ala Lys Asp Asp 
            260                 265                 270         


Glu Gly Val Leu Val Gly Ser Trp Asp Asn Ile Tyr Ala Tyr Gly Val 
        275                 280                 285             


Pro Pro Ser Ala Trp Thr Gly Ser Val Asp Ile Leu Leu Glu Tyr Arg 
    290                 295                 300                 


Ser Ser Glu Asn Pro Val Arg Tyr Gly Gln Cys Trp Val Phe Ala Gly 
305                 310                 315                 320 


Val Phe Asn Thr Phe Leu Arg Cys Leu Gly Ile Pro Ala Arg Ile Val 
                325                 330                 335     


Thr Asn Tyr Phe Ser Ala His Asp Asn Asp Ala Asn Leu Gln Met Asp 
            340                 345                 350         


Ile Phe Leu Glu Glu Asp Gly Asn Val Asn Ser Lys Leu Thr Lys Asp 
        355                 360                 365             


Ser Val Trp Asn Tyr His Cys Trp Asn Glu Ala Trp Met Thr Arg Pro 
    370                 375                 380                 


Asp Leu Pro Val Gly Phe Gly Gly Trp Gln Ala Val Asp Ser Thr Pro 
385                 390                 395                 400 


Gln Glu Asn Ser Asp Gly Met Tyr Arg Cys Gly Pro Ala Ser Val Gln 
                405                 410                 415     


Ala Ile Lys His Gly His Val Cys Phe Gln Phe Asp Ala Pro Phe Val 
            420                 425                 430         


Phe Ala Glu Val Asn Ser Asp Leu Ile Tyr Ile Thr Ala Lys Lys Asp 
        435                 440                 445             


Gly Thr His Val Val Glu Asn Val Asp Ala Thr His Ile Gly Lys Leu 
    450                 455                 460                 


Ile Val Thr Lys Gln Ile Gly Gly Asp Gly Met Met Asp Ile Thr Asp 
465                 470                 475                 480 


Thr Tyr Lys Phe Gln Glu Gly Gln Glu Glu Glu Arg Leu Ala Leu Glu 
                485                 490                 495     


Thr Ala Leu Met Tyr Gly Ala Lys Lys Pro Leu Asn Thr Glu Gly Val 
            500                 505                 510         


Met Lys Ser Arg Ser Asn Val Asp Met Asp Phe Glu Val Glu Asn Ala 
        515                 520                 525             


Val Leu Gly Lys Asp Phe Lys Leu Ser Ile Thr Phe Arg Asn Asn Ser 
    530                 535                 540                 


His Asn Arg Tyr Thr Ile Thr Ala Tyr Leu Ser Ala Asn Ile Thr Phe 
545                 550                 555                 560 


Tyr Thr Gly Val Pro Lys Ala Glu Phe Lys Lys Glu Thr Phe Asp Val 
                565                 570                 575     


Thr Leu Glu Pro Leu Ser Phe Lys Lys Glu Ala Val Leu Ile Gln Ala 
            580                 585                 590         


Gly Glu Tyr Met Gly Gln Leu Leu Glu Gln Ala Ser Leu His Phe Phe 
        595                 600                 605             


Val Thr Ala Arg Ile Asn Glu Thr Arg Asp Val Leu Ala Lys Gln Lys 
    610                 615                 620                 


Ser Thr Val Leu Thr Ile Pro Glu Ile Ile Ile Lys Val Arg Gly Thr 
625                 630                 635                 640 


Gln Val Val Gly Ser Asp Met Thr Val Thr Val Glu Phe Thr Asn Pro 
                645                 650                 655     


Leu Lys Glu Thr Leu Arg Asn Val Trp Val His Leu Asp Gly Pro Gly 
            660                 665                 670         


Val Thr Arg Pro Met Lys Lys Met Phe Arg Glu Ile Arg Pro Asn Ser 
        675                 680                 685             


Thr Val Gln Trp Glu Glu Val Cys Arg Pro Trp Val Ser Gly His Arg 
    690                 695                 700                 


Lys Leu Ile Ala Ser Met Ser Ser Asp Ser Leu Arg His Val Tyr Gly 
705                 710                 715                 720 


Glu Leu Asp Val Gln Ile Gln Arg Arg Pro Ser Met 
                725                 730         


<210>  405
<211>  2437
<212>  DNA
<213>  Homo Sapiens

<400>  405
gcaggagcac gtggagaggc cgagtagcca cagcggcagc tccagcccgg cccggcagcg       60

acatggaaga tatacaaaca aatgcggaac tgaaaagcac tcaggagcag tctgtgcccg      120

cagaaagtgc agcggttttg aatgactaca gtttaaccaa atctcatgaa atggaaaatg      180

tggacagtgg agaaggccca gccaatgaag atgaagacat aggagatgat tcaatgaaag      240

tgaaagatga atacagtgaa agagatgaga atgttttaaa gtcagaaccc atgggaaatg      300

cagaagagcc tgaaatccct tacagctatt caagagaata taatgaatat gaaaacatta      360

agttggagag acatgttgtc tcattcgata gtagcaggcc aaccagtgga aagatgaact      420

gcgatgtgtg tggattatcc tgcatcagct tcaatgtctt aatggttcat aagcgaagcc      480

atactggtga acgcccattc cagtgtaatc agtgtggggc atcttttact cagaaaggta      540

acctcctccg ccacattaaa ctgcacacag gggaaaaacc ttttaagtgt cacctctgca      600

actatgcatg ccaaagaaga gatgcgctca cggggcatct taggacacat tctgtggaga      660

aaccctacaa atgtgagttt tgtggaagga gttacaagca gagaagttcc cttgaggagc      720

acaaggagcg ctgccgtaca tttcttcaga gcactgaccc aggggacact gcaagtgcgg      780

aggcaagaca catcaaagca gagatgggaa gtgaaagagc tctcgtactg gacagattag      840

caagcaatgt ggcaaaacga aaaagctcaa tgcctcagaa attcattggt gagaagcgcc      900

actgctttga tgtcaactat aattcaagtt acatgtatga gaaagagagt gagctcatac      960

agacccgcat gatggaccaa gccatcaata acgccatcag ctatcttggc gccgaagccc     1020

tgcgcccctt ggtccagaca ccgcctgctc ccacctcgga gatggttcca gttatcagca     1080

gcatgtatcc catagccctc acccgggctg agatgtcaaa cggtgcccct caagagctgg     1140

aaaagaaaag catccacctt ccagagaaga gcgtgccttc tgagagaggc ctctctccca     1200

acaatagtgg ccacgactcc acggacactg acagcaacca tgaagaacgc cagaatcaca     1260

tctatcagca aaatcacatg gtcctgtctc gggcccgcaa tgggatgcca cttctgaagg     1320

aggttccccg ctcttacgaa ctcctcaagc ccccgcccat ctgcccaaga gactccgtca     1380

aagtgatcaa caaggaaggg gaggtgatgg atgtgtatcg gtgtgaccac tgccgcgtcc     1440

tcttcctgga ctatgtgatg ttcacgattc acatgggctg ccacggcttc cgtgaccctt     1500

tcgagtgtaa catgtgtgga tatcgaagcc atgatcggta tgagttctcg tctcacatag     1560

ccagaggaga acacagagcc ctgctgaagt gaatatctgg tctcagggat tgctcctatg     1620

tattcagcat cgtttctaaa aaccaatgac ctcgcctaac agattgctct caaaacatac     1680

tcagttccaa acttcttttc ataccatttt tagctgtgtt cacaggggta gccagggaaa     1740

cactgtcttc cttcagaaat tattcgcagg tctagcatat tattactttt gtgaaacctt     1800

tgttttccca tcagggactt gaattttatg gaatttaaaa gccaaaaagg tatttggtca     1860

ttatcttcta cagcagtgga atgagtggtc ccggagatgt gctatatgaa acattctttc     1920

tgagatatat caaccacacg tggaaaagcc tttcagtcat acatgcaaat ccacaaagag     1980

gaagagctga ccagctgacc ttgctgggaa gcctcaccct tctgcccttc acaggctgaa     2040

gggttaagat ctaatctccc taatctaaat gacagtctaa gagtaagtaa aagaacagcc     2100

ataaaataag tatctgttac gagtaactga agaccccatt ctccaagcat cagatccatt     2160

tcctatcaca acatttttaa aaaatgtcat ctgatggcac ttctgcttct gtcctttacc     2220

ttcccatctc cagtgaaaag ctgagctgct ttgggctaaa ccagttgtct atagaagaaa     2280

atctatgcca gaagaactca tggttttaaa tatagaccat catcgaaact ccagaaattt     2340

atccactgtg gatgatgaca tcgctttcct ttggtcaagg ttggcagagc aagggtataa     2400

agggggaaat tgtttggcag caccaacaga aaacaaa                              2437


<210>  406
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  406

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr 
            20                  25                  30          


Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn 
        35                  40                  45              


Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr 
    50                  55                  60                  


Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala 
65                  70                  75                  80  


Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr 
                85                  90                  95      


Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg 
            100                 105                 110         


Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile 
        115                 120                 125             


Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly 
        195                 200                 205             


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
    210                 215                 220                 


Arg Thr Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Ala Ser Ala Glu 
225                 230                 235                 240 


Ala Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu 
                245                 250                 255     


Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln 
            260                 265                 270         


Lys Phe Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn Ser 
        275                 280                 285             


Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met Met 
    290                 295                 300                 


Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu 
305                 310                 315                 320 


Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro 
                325                 330                 335     


Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met Ser 
            340                 345                 350         


Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro Glu 
        355                 360                 365             


Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly His 
    370                 375                 380                 


Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His Ile 
385                 390                 395                 400 


Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met Pro 
                405                 410                 415     


Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro Pro 
            420                 425                 430         


Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu Val 
        435                 440                 445             


Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp Tyr 
    450                 455                 460                 


Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe 
465                 470                 475                 480 


Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser 
                485                 490                 495     


Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
            500                 505                 


<210>  407
<211>  4660
<212>  DNA
<213>  Homo Sapiens

<400>  407
aggttctctg ctctggactt gggaggctcc gttgcctgct cccggaggga gacgcgctgc       60

cgaggagaac ccagcgggag aacatttcag gataggaata ggccaagtgc tgagaagatg      120

agtcttagga ttgatgtgga tacaaacttt cctgagtgtg ttgtagatgc aggaaaagtc      180

acccttggga ctcagcagag gcaggagatg gaccctcgcc tgcgggagaa acagaatgaa      240

atcatcctgc gagcagtatg tgctctgctg aattctggtg ggggcataat caaggctgag      300

attgagaaca aaggctacaa ttatgaacgt catggagtag gattggatgt gcctccaatt      360

ttcagaagcc atttagataa gatgcagaag gaaaaccact ttttgatttt tgtgaaatca      420

tggaacacag aggctggtgt gccacttgct accttatgct ccaatttgta ccacagagag      480

agaacatcca ccgatgtcat ggattctcag gaagctctgg cattcctcaa atgcaggact      540

cagactccaa cgaatattaa tgtttccaat tcattaggtc cacaggcagc tcagggtagt      600

gtacaatatg aaggtaacat aaatgtgtca gctgctgctt tatttgatag aaagcggctt      660

cagtatctgg aaaaactcaa ccttcctgag tccacacatg ttgaatttgt aatgttctcg      720

acagacgtgt cacactgtgt taaagacaga cttccgaagt gtgtttctgc atttgcaaat      780

actgaaggag gatatgtatt ttttggtgtg catgatgaga cttgtcaagt gattggatgt      840

gaaaaagaga aaatagacct tacgagcttg agggcttcta ttgatggctg tattaagaag      900

ctacctgtcc atcatttctg cacacagagg cctgagataa aatatgtcct taacttcctt      960

gaagtgcatg ataagggggc cctccgtgga tatgtctgtg caatcaaggt ggagaaattc     1020

tgctgtgcgg tgtttgccaa agtgcctagt tcctggcagg tgaaggacaa ccgtgtgaga     1080

caattgccca caagagaatg gactgcttgg atgatggaag ctgacccaga cctttccagg     1140

tgtcctgaga tggttctcca gttgagtttg tcatctgcca cgccccgcag caagcctgtg     1200

tgcattcata agaattcgga atgtctgaaa gagcagcaga aacgctactt tccagtattt     1260

tcagacagag tggtatatac tccagaaagc ctctacaagg aactcttctc acaacataaa     1320

ggactcagag acttaataaa tacagaaatg cgccctttct ctcaaggaat attgattttt     1380

tctcaaagct gggctgtgga tttaggtctg caagagaagc agggagtcat ctgtgatgct     1440

cttctaattt cccagaacaa cacccctatt ctctacacca tcttcagcaa gtgggatgcg     1500

gggtgcaagg gctattctat gatagttgcc tattctttga agcagaagct ggtgaacaaa     1560

ggcggctaca ctgggaggtt atgcatcacc cccttggtct gtgtgctgaa ttctgataga     1620

aaagcacaga gcgtttacag ttcgtattta caaatttacc ctgaatccta taacttcatg     1680

accccccagc acatggaagc cctgttacag tccctcgtga tagtcttgct tgggttcaaa     1740

tccttcttaa gtgaagagct gggctctgag gttttgaacc tactgacaaa taaacagtat     1800

gagttgcttt caaagaacct tcgcaagacc agagagttgt ttgttcatgg cttacctgga     1860

tcagggaaga ctatcttggc tcttaggatc atggagaaga tcaggaatgt gtttcactgt     1920

gaaccggcta acattctcta catctgtgaa aaccagcccc tgaagaagtt ggtgagtttc     1980

agcaagaaaa acatctgcca gccagtgacc cggaaaacct tcatgaaaaa caactttgaa     2040

cacatccagc acattatcat tgatgacgct cagaatttcc gtactgaaga tggggactgg     2100

tatgggaaag caaagttcat cactcagaca gcaagggatg gcccaggagt tctctggatc     2160

tttctggact actttcagac ctatcacttg agttgcagtg gcctcccccc tccctcagac     2220

cagtatccaa gagaagagat caacagagtg gtccgcaatg caggtccaat agctaattac     2280

ctacaacaag taatgcagga agcccgacaa aatcctccac ctaacctccc ccctgggtcc     2340

ctggtgatgc tctatgaacc taaatgggct caaggtgtcc caggcaactt agagattatt     2400

gaagacttga acttggagga gatactgatc tatgtagcga ataaatgccg ttttctcttg     2460

cggaatggtt attctccgaa ggatattgct gtgcttttca ccaaagcaag tgaagtggaa     2520

aaatataaag acaggcttct aacagcaatg aggaagagaa aactgtctca gctccatgag     2580

gagtctgatc tgttactaca gatcggtgat gcgtcggatg ttctaaccga tcacattgtg     2640

ttggacagtg tctgtcgatt ttcaggcctg gaaagaaata tcgtgtttgg aatcaatcca     2700

ggagtagccc caccggctgg ggcctacaat cttctgctct gtttggcttc tagggcaaaa     2760

agacatctgt atattctgaa ggcttctgtg tgacaggaaa cccaagccta agaaacaatt     2820

aagtggttct catctctaat taactgtgaa accatttaat ccaaacatgt aagcacacac     2880

tcacttatta agtcacatac ttttctaggt gctggggatt gagaacgaat cgatgtaaga     2940

ttcctccttt agggcagaga cagaccactg acaaatacac agatagacaa ggaatttccc     3000

atggtaaaaa gggatatcag taattagagg accgtgagac tcagagatgt gtgtgtgtgt     3060

gtgtgtgtgt gtgtgtgtgt gtgcgcgcgc gcacgtgcac atgtgtgtag gtagatggag     3120

ggggtgatta ttttgggtgg tcagggaagt gctcagtgag ggaagaactt gtcatgagaa     3180

tctctgagcg tgccaggcag actcggatat ttttataaat ttttaacatg gccacttgca     3240

gaagagcttg aatgggacgt gcagcgagaa tgtgaaggat ggagcaggta gctcatctgg     3300

ccttgtaggt gccgggaacg ggcaagacat gttttgaaat gtaagatcac agactgtttt     3360

ttgcaagacc acattatatt actttattat tttctgcttt ttcttttaac gacattagtg     3420

tttttgatca ctatatttta aaatgctttt tgtgagcctt ttggttatgt ggaatctgtt     3480

ccttagctct gattttttat tcttatggag cgtcttaggt tactacatga aggtaagact     3540

gccacagtcc cccagggagg cacactgtgt tttactgatt gatttgaaga tgatagagag     3600

cctaggggga tgagtctatt ggactcaaag gttacatttt gtttttccat ttaatttaat     3660

aatcaacaaa acgacaaagt cagtttaata tctttcttct gctgagtctt caggatgtta     3720

gctagtcttt caaaagccat tgctacaaaa gtgcaaattt ctcatttcct gtgggtctct     3780

agaaactctc tcaatattta aagccaaaca aatccatctt ttctgagaga cagaaactaa     3840

aaaattcaga gttaattcac tattaaaaac agcaaggccc tgctatttcc caagaataaa     3900

gaaatttaaa attctcattg taagaagtat gaacttgaag ctagaattgg tttatttctg     3960

gcagctactt acaatattaa gaactttact ttttaaattt gagacaattt cacaggaaag     4020

caagaaatta gtctattgtg aaatgttttt acaactaact tggaatatac tgcaaatcac     4080

tagtaagtag agacacattt aagataaaat gattaataaa acaattggta attctgaata     4140

aggatctgaa taaatccaga tcacagactg ttcctttacc aatatgtaaa agaatgtgca     4200

aaattagtaa aaatataccc aaaaatttac cagcaacaga gaagcaaaga atggagttca     4260

accttacact ataaacatct aatagatatg tatgaaaatt taaaaactag aaaaggttgg     4320

gcatggtggc tcatgcttgt gatcccagga ctttaggagg ccaaggtggg aggattgttt     4380

gagcccagga gttcaagacc agcttgagca atatagtgag accctgtctc tacaaaaaca     4440

aacaaacaaa caaacaaata aataaataaa taaaattagc tgggaatggt gatgcacacc     4500

tggagtccta gctactcaga aggctgaggc aggacgatca cttgacctca gaagtctgag     4560

gttacagtga gctatgatca taccagtgca ctccagtctg ggtgacagaa caagaccctg     4620

tctccaaaaa ttaaataaat aaaacaaaaa aaaaaaaaaa                           4660


<210>  408
<211>  891
<212>  PRT
<213>  Homo Sapiens

<400>  408

Met Ser Leu Arg Ile Asp Val Asp Thr Asn Phe Pro Glu Cys Val Val 
1               5                   10                  15      


Asp Ala Gly Lys Val Thr Leu Gly Thr Gln Gln Arg Gln Glu Met Asp 
            20                  25                  30          


Pro Arg Leu Arg Glu Lys Gln Asn Glu Ile Ile Leu Arg Ala Val Cys 
        35                  40                  45              


Ala Leu Leu Asn Ser Gly Gly Gly Ile Ile Lys Ala Glu Ile Glu Asn 
    50                  55                  60                  


Lys Gly Tyr Asn Tyr Glu Arg His Gly Val Gly Leu Asp Val Pro Pro 
65                  70                  75                  80  


Ile Phe Arg Ser His Leu Asp Lys Met Gln Lys Glu Asn His Phe Leu 
                85                  90                  95      


Ile Phe Val Lys Ser Trp Asn Thr Glu Ala Gly Val Pro Leu Ala Thr 
            100                 105                 110         


Leu Cys Ser Asn Leu Tyr His Arg Glu Arg Thr Ser Thr Asp Val Met 
        115                 120                 125             


Asp Ser Gln Glu Ala Leu Ala Phe Leu Lys Cys Arg Thr Gln Thr Pro 
    130                 135                 140                 


Thr Asn Ile Asn Val Ser Asn Ser Leu Gly Pro Gln Ala Ala Gln Gly 
145                 150                 155                 160 


Ser Val Gln Tyr Glu Gly Asn Ile Asn Val Ser Ala Ala Ala Leu Phe 
                165                 170                 175     


Asp Arg Lys Arg Leu Gln Tyr Leu Glu Lys Leu Asn Leu Pro Glu Ser 
            180                 185                 190         


Thr His Val Glu Phe Val Met Phe Ser Thr Asp Val Ser His Cys Val 
        195                 200                 205             


Lys Asp Arg Leu Pro Lys Cys Val Ser Ala Phe Ala Asn Thr Glu Gly 
    210                 215                 220                 


Gly Tyr Val Phe Phe Gly Val His Asp Glu Thr Cys Gln Val Ile Gly 
225                 230                 235                 240 


Cys Glu Lys Glu Lys Ile Asp Leu Thr Ser Leu Arg Ala Ser Ile Asp 
                245                 250                 255     


Gly Cys Ile Lys Lys Leu Pro Val His His Phe Cys Thr Gln Arg Pro 
            260                 265                 270         


Glu Ile Lys Tyr Val Leu Asn Phe Leu Glu Val His Asp Lys Gly Ala 
        275                 280                 285             


Leu Arg Gly Tyr Val Cys Ala Ile Lys Val Glu Lys Phe Cys Cys Ala 
    290                 295                 300                 


Val Phe Ala Lys Val Pro Ser Ser Trp Gln Val Lys Asp Asn Arg Val 
305                 310                 315                 320 


Arg Gln Leu Pro Thr Arg Glu Trp Thr Ala Trp Met Met Glu Ala Asp 
                325                 330                 335     


Pro Asp Leu Ser Arg Cys Pro Glu Met Val Leu Gln Leu Ser Leu Ser 
            340                 345                 350         


Ser Ala Thr Pro Arg Ser Lys Pro Val Cys Ile His Lys Asn Ser Glu 
        355                 360                 365             


Cys Leu Lys Glu Gln Gln Lys Arg Tyr Phe Pro Val Phe Ser Asp Arg 
    370                 375                 380                 


Val Val Tyr Thr Pro Glu Ser Leu Tyr Lys Glu Leu Phe Ser Gln His 
385                 390                 395                 400 


Lys Gly Leu Arg Asp Leu Ile Asn Thr Glu Met Arg Pro Phe Ser Gln 
                405                 410                 415     


Gly Ile Leu Ile Phe Ser Gln Ser Trp Ala Val Asp Leu Gly Leu Gln 
            420                 425                 430         


Glu Lys Gln Gly Val Ile Cys Asp Ala Leu Leu Ile Ser Gln Asn Asn 
        435                 440                 445             


Thr Pro Ile Leu Tyr Thr Ile Phe Ser Lys Trp Asp Ala Gly Cys Lys 
    450                 455                 460                 


Gly Tyr Ser Met Ile Val Ala Tyr Ser Leu Lys Gln Lys Leu Val Asn 
465                 470                 475                 480 


Lys Gly Gly Tyr Thr Gly Arg Leu Cys Ile Thr Pro Leu Val Cys Val 
                485                 490                 495     


Leu Asn Ser Asp Arg Lys Ala Gln Ser Val Tyr Ser Ser Tyr Leu Gln 
            500                 505                 510         


Ile Tyr Pro Glu Ser Tyr Asn Phe Met Thr Pro Gln His Met Glu Ala 
        515                 520                 525             


Leu Leu Gln Ser Leu Val Ile Val Leu Leu Gly Phe Lys Ser Phe Leu 
    530                 535                 540                 


Ser Glu Glu Leu Gly Ser Glu Val Leu Asn Leu Leu Thr Asn Lys Gln 
545                 550                 555                 560 


Tyr Glu Leu Leu Ser Lys Asn Leu Arg Lys Thr Arg Glu Leu Phe Val 
                565                 570                 575     


His Gly Leu Pro Gly Ser Gly Lys Thr Ile Leu Ala Leu Arg Ile Met 
            580                 585                 590         


Glu Lys Ile Arg Asn Val Phe His Cys Glu Pro Ala Asn Ile Leu Tyr 
        595                 600                 605             


Ile Cys Glu Asn Gln Pro Leu Lys Lys Leu Val Ser Phe Ser Lys Lys 
    610                 615                 620                 


Asn Ile Cys Gln Pro Val Thr Arg Lys Thr Phe Met Lys Asn Asn Phe 
625                 630                 635                 640 


Glu His Ile Gln His Ile Ile Ile Asp Asp Ala Gln Asn Phe Arg Thr 
                645                 650                 655     


Glu Asp Gly Asp Trp Tyr Gly Lys Ala Lys Phe Ile Thr Gln Thr Ala 
            660                 665                 670         


Arg Asp Gly Pro Gly Val Leu Trp Ile Phe Leu Asp Tyr Phe Gln Thr 
        675                 680                 685             


Tyr His Leu Ser Cys Ser Gly Leu Pro Pro Pro Ser Asp Gln Tyr Pro 
    690                 695                 700                 


Arg Glu Glu Ile Asn Arg Val Val Arg Asn Ala Gly Pro Ile Ala Asn 
705                 710                 715                 720 


Tyr Leu Gln Gln Val Met Gln Glu Ala Arg Gln Asn Pro Pro Pro Asn 
                725                 730                 735     


Leu Pro Pro Gly Ser Leu Val Met Leu Tyr Glu Pro Lys Trp Ala Gln 
            740                 745                 750         


Gly Val Pro Gly Asn Leu Glu Ile Ile Glu Asp Leu Asn Leu Glu Glu 
        755                 760                 765             


Ile Leu Ile Tyr Val Ala Asn Lys Cys Arg Phe Leu Leu Arg Asn Gly 
    770                 775                 780                 


Tyr Ser Pro Lys Asp Ile Ala Val Leu Phe Thr Lys Ala Ser Glu Val 
785                 790                 795                 800 


Glu Lys Tyr Lys Asp Arg Leu Leu Thr Ala Met Arg Lys Arg Lys Leu 
                805                 810                 815     


Ser Gln Leu His Glu Glu Ser Asp Leu Leu Leu Gln Ile Gly Asp Ala 
            820                 825                 830         


Ser Asp Val Leu Thr Asp His Ile Val Leu Asp Ser Val Cys Arg Phe 
        835                 840                 845             


Ser Gly Leu Glu Arg Asn Ile Val Phe Gly Ile Asn Pro Gly Val Ala 
    850                 855                 860                 


Pro Pro Ala Gly Ala Tyr Asn Leu Leu Leu Cys Leu Ala Ser Arg Ala 
865                 870                 875                 880 


Lys Arg His Leu Tyr Ile Leu Lys Ala Ser Val 
                885                 890     


<210>  409
<211>  2272
<212>  DNA
<213>  Homo Sapiens

<400>  409
agtctccctc cagcgggcgg cgactccggg ttccccctcg cgccctctcg cagaggctcg       60

cccccttccc cgcccaccgt ccctgcgagc gcgggcggcg gcggtgggcg tgtgcgcgcg      120

tgaaggacgc cgcctctctc tcgctcctgc gttcgcaggc ggcggctggc ggccggcttc      180

tcgctcgggc agcggcggcg gcggcggcgg cggcttccgg agtcccgctg cgaagatgct      240

caaagtcacg gtgccctcct gctccgcctc gtcctgctct tcggtcaccg ccagtgcggc      300

cccggggacc gcgagcctcg tcccggatta ctggatcgac ggctccaaca gggatgcgct      360

gagcgatttc ttcgaggtgg agtcggagct gggacggggt gctacatcca ttgtgtacag      420

atgcaaacag aaggggaccc agaagcctta tgctctcaaa gtgttaaaga aaacagtgga      480

caaaaaaatc gtaagaactg agataggagt tcttcttcgc ctctcacatc caaacattat      540

aaaacttaaa gagatatttg aaacccctac agaaatcagt ctggtcctag aactcgtcac      600

aggaggagaa ctgtttgata ggattgtgga aaagggatat tacagtgagc gagatgctgc      660

agatgccgtt aaacaaatcc tggaggcagt tgcttatcta catgaaaatg ggattgtcca      720

tcgtgatctc aaaccagaga atcttcttta tgcaactcca gccccagatg caccactcaa      780

aatcgctgat tttggactct ctaaaattgt ggaacatcaa gtgctcatga agacagtatg      840

tggaacccca gggtactgcg cacctgaaat tcttagaggt tgtgcctatg gacctgaggt      900

ggacatgtgg tctgtaggaa taatcaccta catcttactt tgtggatttg aaccattcta      960

tgatgaaaga ggcgatcagt tcatgttcag gagaattctg aattgtgaat attactttat     1020

ctccccctgg tgggatgaag tatctctaaa tgccaaggac ttggtcagaa aattaattgt     1080

tttggatcca aagaaacggc tgactacatt tcaagctctc cagcatccgt gggtcacagg     1140

taaagcagcc aattttgtac acatggatac cgctcaaaag aagctccaag aattcaatgc     1200

ccggcgtaag cttaaggcag cggtgaaggc tgtggtggcc tcttcccgcc tgggaagtgc     1260

cagcagcagc catggcagca tccaggagag ccacaaggct agccgagacc cttctccaat     1320

ccaagatggc aacgaggaca tgaaagctat tccagaagga gagaaaattc aaggcgatgg     1380

ggcccaagcc gcagttaagg gggcacaggc tgagctgatg aaggtgcaag ccttagagaa     1440

agttaaaggt gcagatataa atgctgaaga ggcccccaaa atggtgccca aggcagtgga     1500

ggatgggata aaggtggctg acctggaact agaggagggc ctagcagagg agaagctgaa     1560

gactgtggag gaggcagcag ctcccagaga agggcaagga agctctgctg tgggttttga     1620

agttccacag caagatgtga tcctgccaga gtactaaaca gcttccttca gatctggaag     1680

ccaaacaccg gcattttatg tactttgtcc ttcagcaaga aaggtgtgga agcatgatat     1740

gtactatagt gattctgttt ttgaggtgca aaaaacatac atatatacca gttggtaatt     1800

ctaacttcaa tgcatgtgac tgctttatga aaataatagt gtcttctatg gcatgtaatg     1860

gatacctaat accgatgagt taaatcttgc aagttaacac aacgtaacac ttaaaagcat     1920

acattttcag caaccagtgg cacatatttg aagtgaatag tagcaaattg tttttgcttt     1980

gaaaatctag ccatcctaca tcctttggat ttcttcacaa ggcagtaatt cctttgaact     2040

actgcttagc taatactagg tagtgctaaa agacatgttc ccataacttt tacaacattt     2100

tactttttat cattgatgtg ttcaaactgt ttacaaggag atgcttatag atgatagttg     2160

tacatatgtg caaaaaaaaa tccacttgca atggtaagaa attgaagtat ccttaaaggc     2220

catgaagcca tatgtcccta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             2272


<210>  410
<211>  473
<212>  PRT
<213>  Homo Sapiens

<400>  410

Met Leu Lys Val Thr Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Thr Ala Ser Ala Ala Pro Gly Thr Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Thr Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Thr Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Thr 
65                  70                  75                  80  


Val Asp Lys Lys Ile Val Arg Thr Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95      


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Thr Pro Thr 
            100                 105                 110         


Glu Ile Ser Leu Val Leu Glu Leu Val Thr Gly Gly Glu Leu Phe Asp 
        115                 120                 125             


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140                 


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160 


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Thr Pro Ala 
                165                 170                 175     


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190         


Glu His Gln Val Leu Met Lys Thr Val Cys Gly Thr Pro Gly Tyr Cys 
        195                 200                 205             


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220                 


Trp Ser Val Gly Ile Ile Thr Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240 


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255     


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270         


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285             


Leu Thr Thr Phe Gln Ala Leu Gln His Pro Trp Val Thr Gly Lys Ala 
    290                 295                 300                 


Ala Asn Phe Val His Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320 


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335     


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350         


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365             


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380                 


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400 


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415     


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430         


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala 
        435                 440                 445             


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460                 


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470             


<210>  411
<211>  1880
<212>  DNA
<213>  Homo Sapiens

<400>  411
gggtcggggc cacaaggccg cgctaggcgg acccaggaca cagcccgcgc gcagcccacc       60

cgcccgccgc ctgccagagc tgctcggccc gcagccaggg ggacagcggc tggtcggagg      120

ctcgcagtgc tgtcggcgag aagcagtcgg gtttggagcg cttgggtcgc gttggtgcgc      180

ggtggaacgc gcccagggac cccagttccc gcgagcagct ccgcgccgcg cctgagagac      240

taagctgaaa ctgctgctca gctcccaaga tggtgccacc caaattgcat gtgcttttct      300

gcctctgcgg ctgcctggct gtggtttatc cttttgactg gcaatacata aatcctgttg      360

cccatatgaa atcatcagca tgggtcaaca aaatacaagt actgatggct gctgcaagct      420

ttggccaaac taaaatcccc cggggaaatg ggccttattc cgttggttgt acagacttaa      480

tgtttgatca cactaataag ggcaccttct tgcgtttata ttatccatcc caagataatg      540

atcgccttga caccctttgg atcccaaata aagaatattt ttggggtctt agcaaatttc      600

ttggaacaca ctggcttatg ggcaacattt tgaggttact ctttggttca atgacaactc      660

ctgcaaactg gaattcccct ctgaggcctg gtgaaaaata tccacttgtt gttttttctc      720

atggtcttgg ggcattcagg acactttatt ctgctattgg cattgacctg gcatctcatg      780

ggtttatagt tgctgctgta gaacacagag atagatctgc atctgcaact tactatttca      840

aggaccaatc tgctgcagaa ataggggaca agtcttggct ctaccttaga accctgaaac      900

aagaggagga gacacatata cgaaatgagc aggtacggca aagagcaaaa gaatgttccc      960

aagctctcag tctgattctt gacattgatc atggaaagcc agtgaagaat gcattagatt     1020

taaagtttga tatggaacaa ctgaaggact ctattgatag ggaaaaaata gcagtaattg     1080

gacattcttt tggtggagca acggttattc agactcttag tgaagatcag agattcagat     1140

gtggtattgc cctggatgca tggatgtttc cactgggtga tgaagtatat tccagaattc     1200

ctcagcccct cttttttatc aactctgaat atttccaata tcctgctaat atcataaaaa     1260

tgaaaaaatg ctactcacct gataaagaaa gaaagatgat tacaatcagg ggttcagtcc     1320

accagaattt tgctgacttc acttttgcaa ctggcaaaat aattggacac atgctcaaat     1380

taaagggaga catagattca aatgtagcta ttgatcttag caacaaagct tcattagcat     1440

tcttacaaaa gcatttagga cttcataaag attttgatca gtgggactgc ttgattgaag     1500

gagatgatga gaatcttatt ccagggacca acattaacac aaccaatcaa cacatcatgt     1560

tacagaactc ttcaggaata gagaaataca attaggatta aaataggttt tttaaaagtc     1620

ttgtttcaaa actgtctaaa attatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag     1680

agagagagag agagagagag agagagagag agaattttaa tgtattttcc caaaggactc     1740

atattttaaa atgtaggcta tactgtaatc gtgattgaag cttggactaa gaattttttc     1800

cctttagatg taaagaaaga atacagtata caatattcaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa                                                 1880


<210>  412
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  412

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  413
<211>  10276
<212>  DNA
<213>  Homo Sapiens

<400>  413
ctcagttgct cccagcagtg gccctgggac cagctctgct ccttgcaccc cgctccctgc       60

ctggacacag gctcactcgc tgccttcttc tgggggaaac cagcttcttg ccagccacag      120

ctgctgcctc cgccactggc caccgcccct gtcctgggag tcccttggcc cagacaccca      180

cctgacttag tggctcctct gcaggaaagg tggctgcccc ctgcgttcct ccatccaacc      240

atgagctggt gcccatcacc actgagaatg caccaaagaa tgtagtggac aagggagaag      300

gagcctcccg gggtggaaac acacggaaaa gcctcgagga caacggctcc accagggtca      360

ccccgagtgt ccagccccac ctccagccca tcagaaacat gagtgtgagc cggaccatgg      420

aggacagctg tgagctggac ctggtgtacg tcacagagag gatcatcgct gtctccttcc      480

ccagcacagc caatgaggag aacttccgga gcaacctccg tgaggtggcg cagatgctca      540

agtccaaaca tggaggcaac tacctgctgt tcaacctctc tgagcggaga cctgacatca      600

cgaagctcca tgccaaggta ctggaatttg gctggcccga cctccacacc ccagccctgg      660

agaagatctg cagcatctgt aaggccatgg acacatggct caatgcagac cctcacaatg      720

tcgttgttct acacaacaag ggaaaccgag gcaggatagg agttgtcatc gcggcttaca      780

tgcactacag caacatttct gccagtgcgg accaggctct ggaccggttt gcaatgaagc      840

ggttctatga ggataagatt gtgcccattg gccagccatc ccaaagaagg tacgtgcatt      900

acttcagtgg cctgctctcc ggctccatca aaatgaacaa caagcccttg tttctgcacc      960

acgtgatcat gcacggcatc cccaactttg agtctaaagg aggatgtcgg ccatttctcc     1020

gcatctacca ggccatgcaa cctgtgtaca catctggcat ctacaacatc ccaggagaca     1080

gccagactag cgtctgcatc accatcgagc caggactgct cttgaaggga gacatcttgc     1140

tgaagtgcta ccacaagaag ttccgaagcc cagcccgaga cgtcatcttc cgtgtgcagt     1200

tccacacctg tgccatccat gacctggggg ttgtctttgg gaaggaggac cttgatgatg     1260

ctttcaaaga tgatcgattt ccagagtatg gcaaagtgga gtttgtattt tcttatgggc     1320

cagagaaaat tcaaggcatg gagcacctgg agaacgggcc gagcgtgtct gtggactata     1380

acacctccga ccccctcatc cgctgggact cctacgacaa cttcagtggg catcgagatg     1440

acggcatgga ggaggtggtg ggacacacgc aggggccact agatgggagc ctgtatgcta     1500

aggtgaagaa gaaagactcc ctgcacggca gcaccggggc tgttaatgcc acacgtccta     1560

cactgtcggc cacccccaac cacgtggaac acacgctttc tgtgagcagc gactcgggca     1620

actccacagc ctccaccaag accgacaaga ccgacgagcc tgtccccggg gcctccagtg     1680

ccactgctgc cttgagtccc caggagaagc gggagctgga ccgcctgctg agtggctttg     1740

gcttagagcg agagaagcaa ggcgccatgt accacaccca gcacctcagg tcccgcccag     1800

cagggggctc ggctgtgccc tcctctggac gccacgttgt cccagcccag gttcatgtca     1860

atggtggggc gttagcatct gagcgggaga cagacatcct ggacgatgaa ttgccaaacc     1920

aggatggtca cagtgcgggc agcatgggca cactctcttc tctggacggg gtcaccaaca     1980

ccagtgaggg gggctaccca gaggccctgt ccccactgac caacggtctg gacaagtcct     2040

accccatgga gcctatggtc aatggaggag gctaccccta cgagtctgcc agccgggcgg     2100

ggcctgccca tgctggccac acggccccca tgcggccctc ctactctgca caggagggtt     2160

tagctggcta ccagagggag gggccccacc cagcctggcc acagccagtg accacctccc     2220

actatgccca tgaccccagc ggtatgttcc gctctcaatc cttttcggaa gctgaacccc     2280

agctgccccc agctccggtc cgagggggaa gcagccggga ggctgtgcaa aggggactga     2340

attcgtggca gcagcagcag cagcagcagc agcagcctcg cccacctcca cgccagcagg     2400

aaagagccca cttggagagt cttgtagcca gcaggcccag ccctcagcca ttggcagaga     2460

cccccatccc cagtctccct gagttcccgc gagcagcctc ccagcaggag attgaacagt     2520

ccatcgaaac actcaatatg ctgatgctgg acctggagcc agcctccgct gctgccccac     2580

tacacaagtc ccagagtgtc cccggggcct ggccaggggc ttctccactc tcctcccagc     2640

ccctctctgg atcctcccgt cagtcccatc cactgaccca gtccagatct ggctatatcc     2700

ccagtgggca ttcgttggga acccctgagc cagccccacg ggcctctctg gagtctgtcc     2760

ctcctggcag gtcttactca ccttatgact atcagccatg tttggctggg cctaaccagg     2820

atttccattc aaagagccca gcctcttcct ccttgcctgc cttccttccg accacccaca     2880

gccctccagg gcctcagcaa cccccagcct ctctccctgg cctcactgct cagcctctgc     2940

tctcaccaaa ggaagcgact tcagacccct cccggactcc agaggaggag ccattgaatt     3000

tagaagggct ggtggcccac agggtagcag gggtacaggc tcgggagaag cagcctgcag     3060

agcccccagc ccctctgcgg aggcgggcgg ccagtgatgg acagtatgag aaccagtctc     3120

cagaagccac atcccctcgt agccctgggg ttcgctcccc tgtccagtgt gtctccccgg     3180

agctggctct taccatcgct ctcaatcctg gagggcggcc caaagagccc catttgcaca     3240

gctacaagga ggccttcgag gagatggagg gaacctcccc gagcagccca ccacccagtg     3300

gggtgcggtc ccccccgggt ctggccaaga cacccctgtc tgctctgggc ctgaaacctc     3360

acaacccagc ggacatcctg ttgcacccca caggagttac cagaagacgg atccagccag     3420

aggaagatga ggggaaggtg gtggtcaggc tgtcagaaga gccccggagc tatgtggagt     3480

ctgtggcacg gacagcggtg gctggacccc gagctcagga ctctgagccc aagagcttta     3540

gtgctccagc cacccaggcc tatggccatg agatacccct gaggaacggg accctgggtg     3600

gctcctttgt ctcccccagc cccctctcca ccagcagccc catcctcagt gctgacagca     3660

cttcagtggg gagtttcccg tcgggagaga gcagtgacca gggtccccgg acgcccaccc     3720

agcctctgtt ggagtctggc ttccgctcag gcagcctggg acagcccagc ccgtctgccc     3780

agagaaacta ccagagctct tctcctctcc cgactgtggg cagtagctac agcagccccg     3840

actactcact tcagcatttc agctcctctc cggaaagcca ggctcgagct cagttcagtg     3900

tggctggcgt ccacacggtg cctgggagcc ctcaggcgcg ccacagaaca gtgggcacca     3960

acactccccc tagtcctggc ttcggctggc gggccatcaa tcccagcatg gctgccccca     4020

gcagtcccag tttgagccat caccagatga tgggtccacc aggcactggc ttccatggta     4080

gcactgtctc cagcccccag agcagtgcag cgaccacccc ggggagcccc agcctgtgtc     4140

ggcacccagc aggggtctac caggtttctg gcctccacaa caaagtggcc accaccccgg     4200

ggagtcccag cctgggccgg caccctgggg ctcaccaagg caacctggcc tccggtcttc     4260

atagcaatgc aatagccagc cctggaagcc ccagcctggg ccgtcacctc ggagggtctg     4320

gatctgtggt tcccggcagc ccctgcttgg accggcatgt ggcctatggt ggctattcta     4380

ccccggagga tcggagaccc acactgtccc ggcagagcag tgcctctggc taccaggctc     4440

cttccacgcc ctccttccct gtctcccctg cctactaccc tggcctgagc agccctgcca     4500

cctccccgtc accagactcc gcagccttcc ggcaagggag cccaacacca gccttgccag     4560

agaagcgaag gatgtcagtg ggagaccggg caggcagcct ccccaactat gccaccatca     4620

atgggaaggt gtcttcgcct gtcgccagcg gcatgtccag tcccagtggg ggcagcaccg     4680

tctccttctc ccacactctg cccgacttct ccaagtactc catgccagac aacagcccgg     4740

agacgcgggc taaagtgaag tttgtccagg acacttctaa gtattggtac aagcctgaga     4800

tctccaggga gcaggccatc gcgctcctca aggaccagga gccgggggcc ttcatcatcc     4860

gcgacagtca ctccttccga ggcgcgtacg ggctggccat gaaggtgtct tcgccacctc     4920

caaccatcat gcagcagaat aaaaaaggag acatgaccca tgagctggtc aggcattttc     4980

tgatagagac tggccccaga ggagtcaagc tcaagggctg ccccaatgag ccaaacttcg     5040

gatcgctgtc tgccctggtc taccagcact ccatcatccc attggccctg ccttgcaagc     5100

tggtcattcc aaaccgagac cccacagatg aatcgaaaga tagctccggc cctgccaact     5160

caactgcaga cctgctgaaa caaggggcag cctgcaatgt gctcttcgtc aactctgtgg     5220

acatggagtc actcactggg ccacaggcca tctctaaagc cacatctgag acgttggctg     5280

cagaccccac gccagctgcc accatcgttc acttcaaagt ctctgcccag ggaatcactc     5340

tgactgacaa ccagagaaag ctctttttca gacgccacta ccctctcaac actgtcacct     5400

tctgtgacct ggatccacag gaaagaaagt ggatgaaaac agagggtggt gcccctgcta     5460

agctcttcgg cttcgtggcc cggaagcagg gcagcaccac ggacaacgcc tgccacctct     5520

ttgctgagct tgaccccaac cagccggcct ctgccatcgt caacttcgtc tccaaggtca     5580

tgctgaatgc cggccaaaag agatgaaccc tgccccttgc ccagggccag tgccatgggg     5640

aaggggcttg tggggagggg acccatgaat cctgaccact cttgaaccca gaaggaggac     5700

tttgggccaa tttcggagga gagaagaaag tgcaacgtgg ggagagggaa gtgaattgca     5760

gaggggaggg ggaaaagaga gagagagaga gagagagaga gagagagaaa gatggaggag     5820

aagaacttgg attcccctgg gtagatggaa actgcaaaaa cccaaagcct ccaaaactaa     5880

ccaggtccac ctaacacccc ctccctcccc taagaagatg gatgtcctca aaagagaagg     5940

aacaaacctc cttgggaatc cacatttttt gggggaatgg aaaagctctg tctccctaac     6000

tcaactgctt tgcaagggga aatcaagctg ggagaatctt tttctggcca cctgtggggt     6060

aggttgtcaa accaaacaga gccaccgtgg gacatcaagt ggaagaactt gtttgcttga     6120

aagtatctca gacccaaggc acctcaggtc tctttgctgt gcctccacta tattgtcgtg     6180

tgggtgtgtg tctgcaccca catcctcaca cattgatcta gatctgcctt tatccactcg     6240

aattataaac agctcggctt gtccttgtcc catgtgtttg tagacacaca tgcatactgt     6300

ccaaagatta gggttggtgg tggcagtgca gcaggggagg gacaaacaac caagctatgg     6360

gtgacagagg ctctctcctg gtgcctgcac ctgcactcta gtgaccctgg gtgccgccag     6420

acccttctct tctacaaaga ccccagcagg agtgggaggg tctgcaatgg catcgccctg     6480

tcctgccttg gccagaagcc tggagctttg gtttgaggag gtagagatat gtgtatccat     6540

aggaagagat ctgtcagaac aggcagctgt tgagctcggg gtgtcttccc caaggcatgt     6600

ggctcagcag caagaaaggc aagttgctcc tgctggggcc ctggactctg ccttagctcc     6660

cacctctcag ccttgttatt gggtttcatg cccctggacc agccttatct cagacctgct     6720

tacctgcatg atgccttttt gggggctggg gattgagtct tgctgctctg cccagccctg     6780

ttctattctg cagggtccct gtgttggaat tctccctggg gaacctactt tctgctcagt     6840

gaggctccgg ccagaaacct ggagtcctta tcctcccctc tgtaagtgtt ttagggtctg     6900

gcttttgcag gcaccctctg acctcagcag agctcctggg cctgctgcct gcacaccaca     6960

tcgcctacct acaatgccaa agcctcactg tcaccctttc tgccttggtt tccctagctg     7020

agccacgctg cccatgcagc agagggcaga aggcttgcac ttgggccaaa gggcctaagg     7080

tccactggac agttgggaaa acacctgacc accatttaag gactctaagc cagaatggaa     7140

aattcaccag gactccattc ttaagcctat gcgagtcccc tagagagagg cattgtactg     7200

atatataaat attatataat atatacatga gacatactga cagaatctgt aagctaataa     7260

aatgtaagaa aaggttaaaa aaagaatagg taaattgaca agaagtattt attgtttttc     7320

catattgctt tattgccttc cttggggata aaccaattcc tatccttttt tatatgtgta     7380

agtaaagcct gaagtgtagg gggcctttgt tcttgaagca gccagggtct ccttgccctg     7440

gccttggcct tccctagact gtgtggggct cagcattggg aggggttgca catgtcccag     7500

cctttggccc ccttactttt cagcaagcca ggggcccagc agtcagctcc caggatgtgt     7560

ggggagctgt ccctgactct gcaggcctga gcgagtgtgt gagcatgcgg ggacatgggt     7620

gtgtatggca cacataggtg cgtgtgtgtc ttttgtattt tttctcctcc aaggagctgt     7680

gtcagtgtgg acgttctgtt tcagggagtt ggaaaggagg gtgtctgcag aaggtggaga     7740

gcaggggcag aggccccact ggccaccccc tgcttcccag agtgaaacct tgtgcctggt     7800

gaccaaagtc cctccaaagt gctcttcctt ctgggttatt caagccaaat atctgggttt     7860

ccccctctcc tcattcccta gcaaacccca attatcttcc aagataggag atatttccca     7920

tccccttcct ttgtaaatat ctcatctccc actggagagc ccaggagcct attcctggca     7980

tggatgttct gtccacactt gaggctgggc ggtgtatcag acccttcaag cagcctggct     8040

ggggcccagg actgagtctg gggtcagctt tcacggtcgc ttttcccttc ctcaccaccc     8100

accacagccc accttgcatg catggccagc ccctccactc cagcctgagc catgtgtgcc     8160

cctgcgggag gacccattca tgccagaaag ctggtaactc cctcccagca tccctgcgga     8220

aggagtcagt ttctgagagt gtgacttttc aaggcgaatg atggggaagg gttccccagt     8280

ccccacagtg gccccacctc tgggccctgc accagagccc ttctgtgtca cggcgggctg     8340

tgcacccatg cacacaccta cgcacacaca acactccgca ctgcagtata ttcttgccaa     8400

agatttcctt taaaagcaag cacttttact aattattatt ttgtaaatgt ttatcttctt     8460

ctgtcttctc cctccctgaa tctattttac tgttgtttat tgttgaatct gtgtgtcagc     8520

caggagagcg ctgtctggcc ttgaacatgg gctgggatgg gaaagggtct gggagaagat     8580

gggcaacaaa gagccaggga gtcatggaca tcgcagcgac gcagacccca gcaggttcag     8640

tcccgtgctg ccaccagctg tccagctggg tgtctggagg gaagagggca gaggagggtc     8700

atgtcccttc agctggggga ggggcccagt gagctccacg tggctttttc ccaaagggag     8760

caagagggaa ggattgggcg agaaaacaat ggagagggga cctgcgaagg aaaacaggga     8820

ggaagtgagc ggtttgatca gcctgctatc acggtgttct ggctctctta tttagccagg     8880

cgcttaaggg acagatacat cacatcctaa gtttgggaaa ggcctttgac ccatgtcatc     8940

tgagcgtctc ctccagtagc tctgaaagct gtggacacca atggccagga ttccttctcc     9000

cctggttttt gaggatccct gggtcttctg agactggcca ggagagggat ggtggggcca     9060

gtggttgtgt gaaagcagga ggggcagccc tcctggacaa gtgtgatccc cctataaacg     9120

gctctcagga ggttagtgag taggagattc tgccttgttc tgatgagcct gtgcaggggc     9180

tccaggggag catgctgtcc agggggcaca gaagggtggt gagtgtgatc aaatctagtc     9240

tcactcccac tttttagtct cactcctact tttgtccacc acccctgcct cctggatctt     9300

ctcccacttt ttttttcagc tttaggacct ggggagatcc tgtgagtcaa ggcagacacc     9360

caatcctgcc cccacactcg gggtcctcca agaggttggg gggcagagtc ccagagcagc     9420

cctttacccc aggtccaggc cctggaatcc tgagactcgc gtttccttgg ccagtggtaa     9480

cacaggacgt gtgtgcgcat gtgcaagtgt ggatgtatgt gtgtgcgtgt gttttgctca     9540

tttctttagg gaacttggga gtcggggttg gaggtgctgg gcaatggaac ttcaaattca     9600

atgtcgccca gcagtgaggg gagtcgggag gtgaggcctg taggccaacc aattggtgga     9660

gtctcagcga tagcccaggt gagaagtggt tcacccagag gggcagggtg ggggcctcgg     9720

gcagatctgt ccctcttggc acctctgtcc tcaaatgtcc aaaatgttgg aggacctctg     9780

ttcatatccc acgcctgggc tcttgccagc agtggagtta ctgtagaggg atgtcccaag     9840

cttgttttcc aatcagtgtt aagctgtttg aaactctcct gtgtctgtgt tttgtttgtg     9900

cgtgtgtgtg agagcacatc agtgtgtgca ggctgtgttt ccccatttct ctcctccctt     9960

cagacccatc attgagaaca aatgtaagaa atcccttccc accaccctcc ctgcctccca    10020

ggccctctgc gggggaaaca agatcaccca gcatccttcc ccaccccagc tgtgtattta    10080

tatagatgga aatatacttt atattttgta tcatcgtgcc tatagccgct gccaccgtgt    10140

ataaatcctg gtgtatgctc cttatcctgg acatgaatgt attgtacact gacgcgtccc    10200

cactcctgta cagctgcttt gtttctttgc aatgcattgt atggctttat aaatgataaa    10260

gttaaagaaa actctg                                                    10276


<210>  414
<211>  1735
<212>  PRT
<213>  Homo Sapiens

<400>  414

Met Ser Val Ser Arg Thr Met Glu Asp Ser Cys Glu Leu Asp Leu Val 
1               5                   10                  15      


Tyr Val Thr Glu Arg Ile Ile Ala Val Ser Phe Pro Ser Thr Ala Asn 
            20                  25                  30          


Glu Glu Asn Phe Arg Ser Asn Leu Arg Glu Val Ala Gln Met Leu Lys 
        35                  40                  45              


Ser Lys His Gly Gly Asn Tyr Leu Leu Phe Asn Leu Ser Glu Arg Arg 
    50                  55                  60                  


Pro Asp Ile Thr Lys Leu His Ala Lys Val Leu Glu Phe Gly Trp Pro 
65                  70                  75                  80  


Asp Leu His Thr Pro Ala Leu Glu Lys Ile Cys Ser Ile Cys Lys Ala 
                85                  90                  95      


Met Asp Thr Trp Leu Asn Ala Asp Pro His Asn Val Val Val Leu His 
            100                 105                 110         


Asn Lys Gly Asn Arg Gly Arg Ile Gly Val Val Ile Ala Ala Tyr Met 
        115                 120                 125             


His Tyr Ser Asn Ile Ser Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe 
    130                 135                 140                 


Ala Met Lys Arg Phe Tyr Glu Asp Lys Ile Val Pro Ile Gly Gln Pro 
145                 150                 155                 160 


Ser Gln Arg Arg Tyr Val His Tyr Phe Ser Gly Leu Leu Ser Gly Ser 
                165                 170                 175     


Ile Lys Met Asn Asn Lys Pro Leu Phe Leu His His Val Ile Met His 
            180                 185                 190         


Gly Ile Pro Asn Phe Glu Ser Lys Gly Gly Cys Arg Pro Phe Leu Arg 
        195                 200                 205             


Ile Tyr Gln Ala Met Gln Pro Val Tyr Thr Ser Gly Ile Tyr Asn Ile 
    210                 215                 220                 


Pro Gly Asp Ser Gln Thr Ser Val Cys Ile Thr Ile Glu Pro Gly Leu 
225                 230                 235                 240 


Leu Leu Lys Gly Asp Ile Leu Leu Lys Cys Tyr His Lys Lys Phe Arg 
                245                 250                 255     


Ser Pro Ala Arg Asp Val Ile Phe Arg Val Gln Phe His Thr Cys Ala 
            260                 265                 270         


Ile His Asp Leu Gly Val Val Phe Gly Lys Glu Asp Leu Asp Asp Ala 
        275                 280                 285             


Phe Lys Asp Asp Arg Phe Pro Glu Tyr Gly Lys Val Glu Phe Val Phe 
    290                 295                 300                 


Ser Tyr Gly Pro Glu Lys Ile Gln Gly Met Glu His Leu Glu Asn Gly 
305                 310                 315                 320 


Pro Ser Val Ser Val Asp Tyr Asn Thr Ser Asp Pro Leu Ile Arg Trp 
                325                 330                 335     


Asp Ser Tyr Asp Asn Phe Ser Gly His Arg Asp Asp Gly Met Glu Glu 
            340                 345                 350         


Val Val Gly His Thr Gln Gly Pro Leu Asp Gly Ser Leu Tyr Ala Lys 
        355                 360                 365             


Val Lys Lys Lys Asp Ser Leu His Gly Ser Thr Gly Ala Val Asn Ala 
    370                 375                 380                 


Thr Arg Pro Thr Leu Ser Ala Thr Pro Asn His Val Glu His Thr Leu 
385                 390                 395                 400 


Ser Val Ser Ser Asp Ser Gly Asn Ser Thr Ala Ser Thr Lys Thr Asp 
                405                 410                 415     


Lys Thr Asp Glu Pro Val Pro Gly Ala Ser Ser Ala Thr Ala Ala Leu 
            420                 425                 430         


Ser Pro Gln Glu Lys Arg Glu Leu Asp Arg Leu Leu Ser Gly Phe Gly 
        435                 440                 445             


Leu Glu Arg Glu Lys Gln Gly Ala Met Tyr His Thr Gln His Leu Arg 
    450                 455                 460                 


Ser Arg Pro Ala Gly Gly Ser Ala Val Pro Ser Ser Gly Arg His Val 
465                 470                 475                 480 


Val Pro Ala Gln Val His Val Asn Gly Gly Ala Leu Ala Ser Glu Arg 
                485                 490                 495     


Glu Thr Asp Ile Leu Asp Asp Glu Leu Pro Asn Gln Asp Gly His Ser 
            500                 505                 510         


Ala Gly Ser Met Gly Thr Leu Ser Ser Leu Asp Gly Val Thr Asn Thr 
        515                 520                 525             


Ser Glu Gly Gly Tyr Pro Glu Ala Leu Ser Pro Leu Thr Asn Gly Leu 
    530                 535                 540                 


Asp Lys Ser Tyr Pro Met Glu Pro Met Val Asn Gly Gly Gly Tyr Pro 
545                 550                 555                 560 


Tyr Glu Ser Ala Ser Arg Ala Gly Pro Ala His Ala Gly His Thr Ala 
                565                 570                 575     


Pro Met Arg Pro Ser Tyr Ser Ala Gln Glu Gly Leu Ala Gly Tyr Gln 
            580                 585                 590         


Arg Glu Gly Pro His Pro Ala Trp Pro Gln Pro Val Thr Thr Ser His 
        595                 600                 605             


Tyr Ala His Asp Pro Ser Gly Met Phe Arg Ser Gln Ser Phe Ser Glu 
    610                 615                 620                 


Ala Glu Pro Gln Leu Pro Pro Ala Pro Val Arg Gly Gly Ser Ser Arg 
625                 630                 635                 640 


Glu Ala Val Gln Arg Gly Leu Asn Ser Trp Gln Gln Gln Gln Gln Gln 
                645                 650                 655     


Gln Gln Gln Pro Arg Pro Pro Pro Arg Gln Gln Glu Arg Ala His Leu 
            660                 665                 670         


Glu Ser Leu Val Ala Ser Arg Pro Ser Pro Gln Pro Leu Ala Glu Thr 
        675                 680                 685             


Pro Ile Pro Ser Leu Pro Glu Phe Pro Arg Ala Ala Ser Gln Gln Glu 
    690                 695                 700                 


Ile Glu Gln Ser Ile Glu Thr Leu Asn Met Leu Met Leu Asp Leu Glu 
705                 710                 715                 720 


Pro Ala Ser Ala Ala Ala Pro Leu His Lys Ser Gln Ser Val Pro Gly 
                725                 730                 735     


Ala Trp Pro Gly Ala Ser Pro Leu Ser Ser Gln Pro Leu Ser Gly Ser 
            740                 745                 750         


Ser Arg Gln Ser His Pro Leu Thr Gln Ser Arg Ser Gly Tyr Ile Pro 
        755                 760                 765             


Ser Gly His Ser Leu Gly Thr Pro Glu Pro Ala Pro Arg Ala Ser Leu 
    770                 775                 780                 


Glu Ser Val Pro Pro Gly Arg Ser Tyr Ser Pro Tyr Asp Tyr Gln Pro 
785                 790                 795                 800 


Cys Leu Ala Gly Pro Asn Gln Asp Phe His Ser Lys Ser Pro Ala Ser 
                805                 810                 815     


Ser Ser Leu Pro Ala Phe Leu Pro Thr Thr His Ser Pro Pro Gly Pro 
            820                 825                 830         


Gln Gln Pro Pro Ala Ser Leu Pro Gly Leu Thr Ala Gln Pro Leu Leu 
        835                 840                 845             


Ser Pro Lys Glu Ala Thr Ser Asp Pro Ser Arg Thr Pro Glu Glu Glu 
    850                 855                 860                 


Pro Leu Asn Leu Glu Gly Leu Val Ala His Arg Val Ala Gly Val Gln 
865                 870                 875                 880 


Ala Arg Glu Lys Gln Pro Ala Glu Pro Pro Ala Pro Leu Arg Arg Arg 
                885                 890                 895     


Ala Ala Ser Asp Gly Gln Tyr Glu Asn Gln Ser Pro Glu Ala Thr Ser 
            900                 905                 910         


Pro Arg Ser Pro Gly Val Arg Ser Pro Val Gln Cys Val Ser Pro Glu 
        915                 920                 925             


Leu Ala Leu Thr Ile Ala Leu Asn Pro Gly Gly Arg Pro Lys Glu Pro 
    930                 935                 940                 


His Leu His Ser Tyr Lys Glu Ala Phe Glu Glu Met Glu Gly Thr Ser 
945                 950                 955                 960 


Pro Ser Ser Pro Pro Pro Ser Gly Val Arg Ser Pro Pro Gly Leu Ala 
                965                 970                 975     


Lys Thr Pro Leu Ser Ala Leu Gly Leu Lys Pro His Asn Pro Ala Asp 
            980                 985                 990         


Ile Leu Leu His Pro Thr Gly Val  Thr Arg Arg Arg Ile  Gln Pro Glu 
        995                 1000                 1005             


Glu Asp  Glu Gly Lys Val Val  Val Arg Leu Ser Glu  Glu Pro Arg 
    1010                 1015                 1020             


Ser Tyr  Val Glu Ser Val Ala  Arg Thr Ala Val Ala  Gly Pro Arg 
    1025                 1030                 1035             


Ala Gln  Asp Ser Glu Pro Lys  Ser Phe Ser Ala Pro  Ala Thr Gln 
    1040                 1045                 1050             


Ala Tyr  Gly His Glu Ile Pro  Leu Arg Asn Gly Thr  Leu Gly Gly 
    1055                 1060                 1065             


Ser Phe  Val Ser Pro Ser Pro  Leu Ser Thr Ser Ser  Pro Ile Leu 
    1070                 1075                 1080             


Ser Ala  Asp Ser Thr Ser Val  Gly Ser Phe Pro Ser  Gly Glu Ser 
    1085                 1090                 1095             


Ser Asp  Gln Gly Pro Arg Thr  Pro Thr Gln Pro Leu  Leu Glu Ser 
    1100                 1105                 1110             


Gly Phe  Arg Ser Gly Ser Leu  Gly Gln Pro Ser Pro  Ser Ala Gln 
    1115                 1120                 1125             


Arg Asn  Tyr Gln Ser Ser Ser  Pro Leu Pro Thr Val  Gly Ser Ser 
    1130                 1135                 1140             


Tyr Ser  Ser Pro Asp Tyr Ser  Leu Gln His Phe Ser  Ser Ser Pro 
    1145                 1150                 1155             


Glu Ser  Gln Ala Arg Ala Gln  Phe Ser Val Ala Gly  Val His Thr 
    1160                 1165                 1170             


Val Pro  Gly Ser Pro Gln Ala  Arg His Arg Thr Val  Gly Thr Asn 
    1175                 1180                 1185             


Thr Pro  Pro Ser Pro Gly Phe  Gly Trp Arg Ala Ile  Asn Pro Ser 
    1190                 1195                 1200             


Met Ala  Ala Pro Ser Ser Pro  Ser Leu Ser His His  Gln Met Met 
    1205                 1210                 1215             


Gly Pro  Pro Gly Thr Gly Phe  His Gly Ser Thr Val  Ser Ser Pro 
    1220                 1225                 1230             


Gln Ser  Ser Ala Ala Thr Thr  Pro Gly Ser Pro Ser  Leu Cys Arg 
    1235                 1240                 1245             


His Pro  Ala Gly Val Tyr Gln  Val Ser Gly Leu His  Asn Lys Val 
    1250                 1255                 1260             


Ala Thr  Thr Pro Gly Ser Pro  Ser Leu Gly Arg His  Pro Gly Ala 
    1265                 1270                 1275             


His Gln  Gly Asn Leu Ala Ser  Gly Leu His Ser Asn  Ala Ile Ala 
    1280                 1285                 1290             


Ser Pro  Gly Ser Pro Ser Leu  Gly Arg His Leu Gly  Gly Ser Gly 
    1295                 1300                 1305             


Ser Val  Val Pro Gly Ser Pro  Cys Leu Asp Arg His  Val Ala Tyr 
    1310                 1315                 1320             


Gly Gly  Tyr Ser Thr Pro Glu  Asp Arg Arg Pro Thr  Leu Ser Arg 
    1325                 1330                 1335             


Gln Ser  Ser Ala Ser Gly Tyr  Gln Ala Pro Ser Thr  Pro Ser Phe 
    1340                 1345                 1350             


Pro Val  Ser Pro Ala Tyr Tyr  Pro Gly Leu Ser Ser  Pro Ala Thr 
    1355                 1360                 1365             


Ser Pro  Ser Pro Asp Ser Ala  Ala Phe Arg Gln Gly  Ser Pro Thr 
    1370                 1375                 1380             


Pro Ala  Leu Pro Glu Lys Arg  Arg Met Ser Val Gly  Asp Arg Ala 
    1385                 1390                 1395             


Gly Ser  Leu Pro Asn Tyr Ala  Thr Ile Asn Gly Lys  Val Ser Ser 
    1400                 1405                 1410             


Pro Val  Ala Ser Gly Met Ser  Ser Pro Ser Gly Gly  Ser Thr Val 
    1415                 1420                 1425             


Ser Phe  Ser His Thr Leu Pro  Asp Phe Ser Lys Tyr  Ser Met Pro 
    1430                 1435                 1440             


Asp Asn  Ser Pro Glu Thr Arg  Ala Lys Val Lys Phe  Val Gln Asp 
    1445                 1450                 1455             


Thr Ser  Lys Tyr Trp Tyr Lys  Pro Glu Ile Ser Arg  Glu Gln Ala 
    1460                 1465                 1470             


Ile Ala  Leu Leu Lys Asp Gln  Glu Pro Gly Ala Phe  Ile Ile Arg 
    1475                 1480                 1485             


Asp Ser  His Ser Phe Arg Gly  Ala Tyr Gly Leu Ala  Met Lys Val 
    1490                 1495                 1500             


Ser Ser  Pro Pro Pro Thr Ile  Met Gln Gln Asn Lys  Lys Gly Asp 
    1505                 1510                 1515             


Met Thr  His Glu Leu Val Arg  His Phe Leu Ile Glu  Thr Gly Pro 
    1520                 1525                 1530             


Arg Gly  Val Lys Leu Lys Gly  Cys Pro Asn Glu Pro  Asn Phe Gly 
    1535                 1540                 1545             


Ser Leu  Ser Ala Leu Val Tyr  Gln His Ser Ile Ile  Pro Leu Ala 
    1550                 1555                 1560             


Leu Pro  Cys Lys Leu Val Ile  Pro Asn Arg Asp Pro  Thr Asp Glu 
    1565                 1570                 1575             


Ser Lys  Asp Ser Ser Gly Pro  Ala Asn Ser Thr Ala  Asp Leu Leu 
    1580                 1585                 1590             


Lys Gln  Gly Ala Ala Cys Asn  Val Leu Phe Val Asn  Ser Val Asp 
    1595                 1600                 1605             


Met Glu  Ser Leu Thr Gly Pro  Gln Ala Ile Ser Lys  Ala Thr Ser 
    1610                 1615                 1620             


Glu Thr  Leu Ala Ala Asp Pro  Thr Pro Ala Ala Thr  Ile Val His 
    1625                 1630                 1635             


Phe Lys  Val Ser Ala Gln Gly  Ile Thr Leu Thr Asp  Asn Gln Arg 
    1640                 1645                 1650             


Lys Leu  Phe Phe Arg Arg His  Tyr Pro Leu Asn Thr  Val Thr Phe 
    1655                 1660                 1665             


Cys Asp  Leu Asp Pro Gln Glu  Arg Lys Trp Met Lys  Thr Glu Gly 
    1670                 1675                 1680             


Gly Ala  Pro Ala Lys Leu Phe  Gly Phe Val Ala Arg  Lys Gln Gly 
    1685                 1690                 1695             


Ser Thr  Thr Asp Asn Ala Cys  His Leu Phe Ala Glu  Leu Asp Pro 
    1700                 1705                 1710             


Asn Gln  Pro Ala Ser Ala Ile  Val Asn Phe Val Ser  Lys Val Met 
    1715                 1720                 1725             


Leu Asn  Ala Gly Gln Lys Arg  
    1730                 1735 


<210>  415
<211>  774
<212>  DNA
<213>  Homo Sapiens

<400>  415
agggcaagtt aagggaatag tggaatgaag gttcattttt cattctcaca aactaatgaa       60

accctgctta tcttaaacca acctgctcac tggagcaggg aggacaggac cagcataaaa      120

ggcagggcag agtcgactgt tgcttacact ttcttctgac ataacagtgt tcactagcaa      180

cctcaaacag acaccatggt gcatctgact cctgaggaga agactgctgt caatgccctg      240

tggggcaaag tgaacgtgga tgcagttggt ggtgaggccc tgggcagatt actggtggtc      300

tacccttgga cccagaggtt ctttgagtcc tttggggatc tgtcctctcc tgatgctgtt      360

atgggcaacc ctaaggtgaa ggctcatggc aagaaggtgc taggtgcctt tagtgatggc      420

ctggctcacc tggacaacct caagggcact ttttctcagc tgagtgagct gcactgtgac      480

aagctgcacg tggatcctga gaacttcagg ctcttgggca atgtgctggt gtgtgtgctg      540

gcccgcaact ttggcaagga attcacccca caaatgcagg ctgcctatca gaaggtggtg      600

gctggtgtgg ctaatgccct ggctcacaag taccattgag atcctggact gtttcctgat      660

aaccataaga agaccctatt tccctagatt ctattttctg aacttgggaa cacaatgcct      720

acttcaaggg tatggcttct gcctaataaa gaatgttcag ctcaacttcc tgat            774


<210>  416
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  416

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  417
<211>  1730
<212>  DNA
<213>  Homo Sapiens

<400>  417
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agtaggtgtg caccagccct ggcaacgaga gcgtctaccc cgaactctgc      240

tggccttgag gtggggaagc cggggagggc agttgaggac cccgcggagg cgcgtgactg      300

gttgagcggg caggccagcc tccgagccgg gtggacacag gttttaaaac atgaatccta      360

cactcatcct tgctgccttt tgcctgggaa ttgcctcagc tactctaaca tttgatcaca      420

gtttagaggc acagtggacc aagtggaagg cgatgcacaa cagattatac ggcatgaatg      480

aagaaggatg gaggagagca gtgtgggaga agaacatgaa gatgattgaa ctgcacaatc      540

aggaatacag ggaagggaaa cacagcttca caatggccat gaacgccttt ggagacatga      600

ccagtgaaga attcaggcag gtgatgaatg gctttcaaaa ccgtaagccc aggaagggga      660

aagtgttcca ggaacctctg ttttatgagg cccccagatc tgtggattgg agagagaaag      720

gctacgtgac tcctgtgaag aatcagggtc agtgtggttc ttgttgggct tttagtgcta      780

ctggtgctct tgaaggacag atgttccgga aaactgggag gcttatctca ctgagtgagc      840

agaatctggt agactgctct gggcctcaag gcaatgaagg ctgcaatggt ggcctaatgg      900

attatgcttt ccagtatgtt caggataatg gaggcctgga ctctgaggaa tcctatccat      960

atgaggcaac agaagaatcc tgtaagtaca atcccaagta ttctgttgct aatgacaccg     1020

gctttgtgga catccctaag caggagaagg ccctgatgaa ggcagttgca actgtggggc     1080

ccatttctgt tgctattgat gcaggtcatg agtccttcct gttctataaa gaaggcattt     1140

attttgagcc agactgtagc agtgaagaca tggatcatgg tgtgctggtg gttggctacg     1200

gatttgaaag cacagaatca gataacaata aatattggct ggtgaagaac agctggggtg     1260

aagaatgggg catgggtggc tacgtaaaga tggccaaaga ccggagaaac cattgtggaa     1320

ttgcctcagc agccagctac cccactgtgt gagctggtgg acggtgatga ggaaggactt     1380

gactggggat ggcgcatgca tgggaggaat tcatcttcag tctaccagcc cccgctgtgt     1440

cggatacaca ctcgaatcat tgaagatccg agtgtgattt gaattctgtg atattttcac     1500

actggtaaat gttacctcta ttttaattac tgctataaat aggtttatat tattgattca     1560

cttactgact ttgcattttc gtttttaaaa ggatgtataa atttttacct gtttaaataa     1620

aatttaattt caaatgtagt ggtggggctt ctttctattt ttgatgcact gaatttttgt     1680

gtaataaaga acataattgg gctctaagcc ataaaaaaaa aaaaaaaaaa                1730


<210>  418
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  418

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  419
<211>  2442
<212>  DNA
<213>  Homo Sapiens

<400>  419
aggaggaagg ggagggaaaa ggggaggagg aggaggatgt gagactgggt tagagaaatg       60

aaagaaagca aggctttctg ttgacattca gtgcagtcta cctgcagcac agcacactcc      120

ctttgggcaa ggacctgaga cccttgtgct aagtcaagag gctcaatggg ctgcagaaga      180

actagagaag gaccaagcaa agccatgata tttccatgga aatgtcagag cacccagagg      240

gacttatgga acatcttcaa gttgtggggg tggacaatgc tctgttgtga tttcctggca      300

catcatggaa ccgactgctg gacttaccat tattctgaaa aacccatgaa ctggcaaagg      360

gctagaagat tctgccgaga caattacaca gatttagttg ccatacaaaa caaggcggaa      420

attgagtatc tggagaagac tctgcctttc agtcgttctt actactggat aggaatccgg      480

aagataggag gaatatggac gtgggtggga accaacaaat ctcttactga agaagcagag      540

aactggggag atggtgagcc caacaacaag aagaacaagg aggactgcgt ggagatctat      600

atcaagagaa acaaagatgc aggcaaatgg aacgatgacg cctgccacaa actaaaggca      660

gccctctgtt acacagcttc ttgccagccc tggtcatgca gtggccatgg agaatgtgta      720

gaaatcatca ataattacac ctgcaactgt gatgtggggt actatgggcc ccagtgtcag      780

tttgtgattc agtgtgagcc tttggaggcc ccagagctgg gtaccatgga ctgtactcac      840

cctttgggaa acttcagctt cagctcacag tgtgccttca gctgctctga aggaacaaac      900

ttaactggga ttgaagaaac cacctgtgga ccatttggaa actggtcatc tccagaacca      960

acctgtcaag tgattcagtg tgagcctcta tcagcaccag atttggggat catgaactgt     1020

agccatcccc tggccagctt cagctttacc tctgcatgta ccttcatctg ctcagaagga     1080

actgagttaa ttgggaagaa gaaaaccatt tgtgaatcat ctggaatctg gtcaaatcct     1140

agtccaatat gtcaaaaatt ggacaaaagt ttctcaatga ttaaggaggg tgattataac     1200

cccctcttca ttccagtggc agtcatggtt actgcattct ctgggttggc atttatcatt     1260

tggctggcaa ggagattaaa aaaaggcaag aaatccaaga gaagtatgaa tgacccatat     1320

taaatcgccc ttggtgaaag aaaattcttg gaatactaaa aatcatgaga tcctttaaat     1380

ccttccatga aacgttttgt gtggtggcac ctcctacgtc aaacatgaag tgtgtttcct     1440

tcagtgcatc tgggaagatt tctacctgac caacagttcc ttcagcttcc atttcgcccc     1500

tcatttatcc ctcaaccccc agcccacagg tgtttataca gctcagcttt ttgtcttttc     1560

tgaggagaaa caaataagac cataaaggga aaggattcat gtggaatata aagatggctg     1620

actttgctct ttcttgactc ttgttttcag tttcaattca gtgctgtact tgatgacaga     1680

cacttctaaa tgaagtgcaa atttgataca tatgtgaata tggactcagt tttcttgcag     1740

atcaaatttc acgtcgtctt ctgtatactg tggaggtaca ctcttataga aagttcaaaa     1800

agtctacgct ctcctttctt tctaactcca gtgaagtaat ggggtcctgc tcaagttgaa     1860

agagtcctat ttgcactgta gcctcgccgt ctgtgaattg gaccatccta tttaactggc     1920

ttcagcctcc ccaccttctt cagccacctc tctttttcag ttggctgact tccacaccta     1980

gcatctcatg agtgccaagc aaaaggagag aagagagaaa tagcctgcgc tgttttttag     2040

tttgggggtt ttgctgtttc cttttatgag acccattcct atttcttata gtcaatgttt     2100

cttttatcac gatattatta gtaagaaaac atcactgaaa tgctagctgc aagtgacatc     2160

tctttgatgt catatggaag agttaaaaca ggtggagaaa ttccttgatt cacaatgaaa     2220

tgctctcctt tcccctgccc ccagaccttt tatccactta cctagattct acatattctt     2280

taaatttcat ctcaggcctc cctcaacccc accacttctt ttataactag tcctttacta     2340

atccaaccca tgatgagctc ctcttcctgg cttcttactg aaaggttacc ctgtaacatg     2400

caattttgca tttgaataaa gcctgctttt taagtgttaa ct                        2442


<210>  420
<211>  385
<212>  PRT
<213>  Homo Sapiens

<400>  420

Met Gly Cys Arg Arg Thr Arg Glu Gly Pro Ser Lys Ala Met Ile Phe 
1               5                   10                  15      


Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn Ile Phe Lys 
            20                  25                  30          


Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala His His Gly 
        35                  40                  45              


Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln 
    50                  55                  60                  


Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile 
65                  70                  75                  80  


Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser 
                85                  90                  95      


Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr 
            100                 105                 110         


Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly 
        115                 120                 125             


Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile 
    130                 135                 140                 


Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys 
145                 150                 155                 160 


His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp 
                165                 170                 175     


Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr 
            180                 185                 190         


Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile 
        195                 200                 205             


Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr 
    210                 215                 220                 


His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys 
225                 230                 235                 240 


Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro 
                245                 250                 255     


Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys 
            260                 265                 270         


Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro 
        275                 280                 285             


Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu 
    290                 295                 300                 


Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly 
305                 310                 315                 320 


Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe 
                325                 330                 335     


Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala 
            340                 345                 350         


Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala 
        355                 360                 365             


Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro 
    370                 375                 380                 


Tyr 
385 


<210>  421
<211>  1953
<212>  DNA
<213>  Homo Sapiens

<400>  421
acagaaccca gaaaaacaac tcattcgctt tcatttcctc actgactata aaagaataga       60

gaaggaaggg cttcagtgac cggctgcctg gctgacttac agcagtcaga ctctgacagg      120

atcatggcta tgatggaggt ccagggggga cccagcctgg gacagacctg cgtgctgatc      180

gtgatcttca cagtgctcct gcagtctctc tgtgtggctg taacttacgt gtactttacc      240

aacgagctga agcagatgca ggacaagtac tccaaaagtg gcattgcttg tttcttaaaa      300

gaagatgaca gttattggga ccccaatgac gaagagagta tgaacagccc ctgctggcaa      360

gtcaagtggc aactccgtca gctcgttaga aagatgattt tgagaacctc tgaggaaacc      420

atttctacag ttcaagaaaa gcaacaaaat atttctcccc tagtgagaga aagaggtcct      480

cagagagtag cagctcacat aactgggacc agaggaagaa gcaacacatt gtcttctcca      540

aactccaaga atgaaaaggc tctgggccgc aaaataaact cctgggaatc atcaaggagt      600

gggcattcat tcctgagcaa cttgcacttg aggaatggtg aactggtcat ccatgaaaaa      660

gggttttact acatctattc ccaaacatac tttcgatttc aggaggaaat aaaagaaaac      720

acaaagaacg acaaacaaat ggtccaatat atttacaaat acacaagtta tcctgaccct      780

atattgttga tgaaaagtgc tagaaatagt tgttggtcta aagatgcaga atatggactc      840

tattccatct atcaaggggg aatatttgag cttaaggaaa atgacagaat ttttgtttct      900

gtaacaaatg agcacttgat agacatggac catgaagcca gtttttttgg ggccttttta      960

gttggctaac tgacctggaa agaaaaagca ataacctcaa agtgactatt cagttttcag     1020

gatgatacac tatgaagatg tttcaaaaaa tctgaccaaa acaaacaaac agaaaacaga     1080

aaacaaaaaa acctctatgc aatctgagta gagcagccac aaccaaaaaa ttctacaaca     1140

cacactgttc tgaaagtgac tcacttatcc caagagaatg aaattgctga aagatctttc     1200

aggactctac ctcatatcag tttgctagca gaaatctaga agactgtcag cttccaaaca     1260

ttaatgcaat ggttaacatc ttctgtcttt ataatctact ccttgtaaag actgtagaag     1320

aaagagcaac aatccatctc tcaagtagtg tatcacagta gtagcctcca ggtttcctta     1380

agggacaaca tccttaagtc aaaagagaga agaggcacca ctaaaagatc gcagtttgcc     1440

tggtgcagtg gctcacacct gtaatcccaa cattttggga acccaaggtg ggtagatcac     1500

gagatcaaga gatcaagacc atagtgacca acatagtgaa accccatctc tactgaaagt     1560

acaaaaatta gctgggtgtg ttggcacatg cctgtagtcc cagctacttg agaggctgag     1620

gcaagagaat tgtttgaacc cgggaggcag aggttgcagt gtggtgagat catgccacta     1680

cactccagcc tggcgacaga gcgagacttg gtttcaaaaa aaaaaaaaaa aaaaacttca     1740

gtaagtacgt gttatttttt tcaataaaat tctattacag tatgtcatgt ttgctgtagt     1800

gctcatattt attgttgttt ttgttttagt actcacttgt ttcataatat caagattact     1860

aaaaatgggg gaaaagactt ctaatctttt tttcataata tctttgacac atattacaga     1920

agaaataaat ttcttacttt taatttaata tga                                  1953


<210>  422
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  422

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  423
<211>  2702
<212>  DNA
<213>  Homo Sapiens

<400>  423
atttaaatgt tagatcacga ggaagaagga aaacgatttc aagagctgca cttaagcatc       60

tagaattttc tgcgtcacac ctcttgagag aagagactgg ctccaggtct gactcagtcc      120

actacaagct agacggtctt cttaaagcac caacattact tgagtctttg gataaaattg      180

agaaaagagt ctacaagtat tgtggactct acaggaggca ggaggctgac aactggcagt      240

aaagacaaag atgtcaggcc tgcggcccgg cactcaagtg gaccctgaga ttgagctttt      300

tgtaaaggct ggaagtgatg gagagagtat tggaaactgt cccttttgcc aacgcctttt      360

catgatcctc tggcttaaag gagttaaatt taatgtgaca actgttgaca tgaccagaaa      420

gcctgaagaa ctaaaggact tagccccagg taccaatcct ccgttcctgg tgtataacaa      480

ggagttgaaa acagacttca ttaaaattga ggagttttta gaacaaaccc tggctcctcc      540

aaggtaccct cacctgagtc ccaagtacaa ggagtctttt gatgtgggct gtaacctctt      600

tgccaagttt tctgcataca ttaagaatac acaaaaggag gcaaataaga attttgaaaa      660

atctctgctc aaagaattca agcgtctgga tgactactta aacaccccac ttctggatga      720

aattgatcca gacagtgctg aggaaccccc agtttccaga agactattct tggatgggga      780

ccagctaaca ctggctgatt gtagcttgtt acccaagctg aacattatta aagttgctgc      840

caagaaatat cgtgactttg acattccagc agaattctca ggagtctggc gttatctcca      900

caatgcctat gcccgtgaag aatttaccca cacgtgtcct gaagacaaag aaattgaaaa      960

tacttacgca aatgtggcta aacagaagag ttaggagagc tcttacagga gaaaaggcta     1020

tatttgtgat cagattttac ttattgacat attagaaagg tttttgcaaa taagaatatg     1080

aaaaatactg tttcttctat ccaactctct tatgaaaagg aactctgtat tttctattag     1140

ccataaataa tctgtccact gtattttaca ggtcttcata cttttactta attttcttta     1200

tctgtatggc aaaccactgc aatcctgaat gacatggaaa gcatcacaat cttttgccct     1260

ttgcttgaat tcctggaatg catacatata agctaaacag atgtctgcag ttataaatgt     1320

cataagtaga ggtacaatct caccctgctc cttagaaaca tttccatata aatcgctaaa     1380

ataatttcac atttttgtta gtttaatata tacatgagtt tatttctgat ataaataata     1440

aatacagaga gtgagcatat cagagaggca aattcttaaa gaatgatttt taaaatcagc     1500

tctaggaaga gctcaagatc aattggtcat agaacagcat ttgacgccta gaactatgac     1560

cacctcatgg tcagagatga gaatgtagcc tttgtgacca gattatatta tttttaaatg     1620

aagaagcact cattaaataa aacataattt taaaaaacaa tataagaaac aaagtcaact     1680

gaatctttta ttcatagaaa tgaaaaggaa aataaaaact gtggctgacc aaaaggtctt     1740

cttgttgtcc ataaaaggat aaggtaaaca gtccttagat aattacaaaa ctttctacaa     1800

aagttaaaat gttacattac tatacgtatt cagattcact tgttaaagta ctcttaaatc     1860

attcaaatct ggaaacaaaa gctgaactta actcttgctc cctcaaaaga gaaacacaag     1920

cataagtgca gcttcaaaaa aggaaaatat tttaggcttt ggtggaaggg tggagtttag     1980

ataaaattta aatgaagtag cgttttaata ggttcaaaga aaagtaaggc aatgagcaaa     2040

ctcaaagtac tgtccttgaa aaccatagag tcaagataaa tgtatagtgt atggttaggt     2100

ggcagagaaa tgcaatcatg ttgataatct ttgagataca tcctgtcatc agtatatttc     2160

agaatacatg caatgcacta gcaagttaca attgatagaa tacatttgaa atgttaaatg     2220

aaataagcca ggcacagaaa gacaaacacc acatgatctc actcatatgt ggaattttaa     2280

aaagttgatc tcactcatat gtggaatttt aaaaagttga tctcacacaa gtagagggta     2340

gaatcgtggt taccaggggc tagggagaga aagaaggcag aggcactgaa agatgttggt     2400

caatgggtat aaagttacac ctaggaagaa taaattttgg tattcaccac agtagggtga     2460

ctatagcaaa taataatgta gcatgtattt caagatagct agaaaagcag gtttttaaat     2520

gtcaccacaa agaaataaca aatgtttata gtggtggata tggtaattac gcctatttga     2580

tcattatact gtgtgtacat gcattgaaac accacattgt atcccatata tatgtacaat     2640

tatgtgccca ttatacattt aaaaaataaa ttttaaaaac cttcaaaaaa aaaaaaaaaa     2700

aa                                                                    2702


<210>  424
<211>  247
<212>  PRT
<213>  Homo Sapiens

<400>  424

Met Ser Gly Leu Arg Pro Gly Thr Gln Val Asp Pro Glu Ile Glu Leu 
1               5                   10                  15      


Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile Gly Asn Cys Pro Phe 
            20                  25                  30          


Cys Gln Arg Leu Phe Met Ile Leu Trp Leu Lys Gly Val Lys Phe Asn 
        35                  40                  45              


Val Thr Thr Val Asp Met Thr Arg Lys Pro Glu Glu Leu Lys Asp Leu 
    50                  55                  60                  


Ala Pro Gly Thr Asn Pro Pro Phe Leu Val Tyr Asn Lys Glu Leu Lys 
65                  70                  75                  80  


Thr Asp Phe Ile Lys Ile Glu Glu Phe Leu Glu Gln Thr Leu Ala Pro 
                85                  90                  95      


Pro Arg Tyr Pro His Leu Ser Pro Lys Tyr Lys Glu Ser Phe Asp Val 
            100                 105                 110         


Gly Cys Asn Leu Phe Ala Lys Phe Ser Ala Tyr Ile Lys Asn Thr Gln 
        115                 120                 125             


Lys Glu Ala Asn Lys Asn Phe Glu Lys Ser Leu Leu Lys Glu Phe Lys 
    130                 135                 140                 


Arg Leu Asp Asp Tyr Leu Asn Thr Pro Leu Leu Asp Glu Ile Asp Pro 
145                 150                 155                 160 


Asp Ser Ala Glu Glu Pro Pro Val Ser Arg Arg Leu Phe Leu Asp Gly 
                165                 170                 175     


Asp Gln Leu Thr Leu Ala Asp Cys Ser Leu Leu Pro Lys Leu Asn Ile 
            180                 185                 190         


Ile Lys Val Ala Ala Lys Lys Tyr Arg Asp Phe Asp Ile Pro Ala Glu 
        195                 200                 205             


Phe Ser Gly Val Trp Arg Tyr Leu His Asn Ala Tyr Ala Arg Glu Glu 
    210                 215                 220                 


Phe Thr His Thr Cys Pro Glu Asp Lys Glu Ile Glu Asn Thr Tyr Ala 
225                 230                 235                 240 


Asn Val Ala Lys Gln Lys Ser 
                245         


<210>  425
<211>  5113
<212>  DNA
<213>  Homo Sapiens

<400>  425
agaaacgctt ttctgcggtc cagtctaggg ggtctcagat tggcggggat gggcagcagc       60

ggcaggtggc cttggctttt gctgcagccg tcaacgacct atcatcgggg tcctgcgtaa      120

ggtccggctg gctgggactt ggctgtgggt gggatggact ggctgccgga ccgagtgccc      180

tgcagttggt aggagtatga ggcagagtga tgcacacccg ggcgcccagc atcgttctaa      240

ttgccggaga cattgcctca gactgtgcgc tgctagaggc tgcgttcctg agcaggaagc      300

ccgtttcctg ggattggaac tacccttctt ggccagcggg aagtccccaa ggacggagtc      360

gaaaggtcaa atcttatctg tcagtgctgt gtgacagcat cgcaacggga tctgcagaac      420

ctgaactcga tccgtaatgc ctcctgcctg cctctttcaa gatggaggtg aaacctgtgg      480

gagaacctac tcaagaggtg tctaaattca aactttccac caaggtagaa agcacgggac      540

actggctggt ggaagatcat gttcgaatat gggaagtttt aaagacagag gagagctcga      600

ttcaggactg gggtgaagag gtagaggaag gagctgttta ccatgtcacc ctcaaaagag      660

tccagattca acaggctgcc aataaaggag caagatggct aggggttgaa ggggaccagc      720

tgcctccagg acacacagtc agtcaatatg aaacctgtaa gatcaggacc ataaaagctg      780

gcaccttgga gaagcttgtg gagaacctgc tgacagcttt tggggacaat gactttacct      840

atatcagcat ctttctttca acgtacagag gctttgcctc cactaaagaa gtgctggaac      900

tactgctgga caggtatgga aacctgacaa gcccaaactg tgaagaagat ggaagccaaa      960

gttcatcaga gtccaaaatg gtgatcagga atgcaatcgc ttccatacta agggcctggc     1020

ttgaccagtg tgcagaagac ttccgagagc cccctcactt cccttgctta cagaaactgc     1080

tggattatct cacacggatg atgccgggct ctgacccaga aagaagagca caaaatcttc     1140

ttgagcagtt tcagaagcaa gaagtggaaa ctgacaatgg gcttcccaac acgatctcct     1200

tcagcctgga agaggaagag gaactggagg gtggagagtc agcagaattc acgtgcttct     1260

cagaagatct cgtggcagag cagctgacct acatggatgc acaactcttc aagaaagtag     1320

tgcctcacca ctgcctgggc tgcatttggt ctcgaaggga taagaaggaa aacaaacatt     1380

tggctcctac gatccgtgcc accatctctc agtttaatac cctcaccaaa tgtgttgtca     1440

gcaccatcct ggggggcaaa gaactcaaaa ctcagcagag agccaaaatc attgagaagt     1500

ggatcaacat cgctcatgaa tgtagactcc tgaagaattt ttcctccttg agggccatcg     1560

tttcggcact gcagtctaat tccatctatc ggttaaaaaa gacttgggct gccgtcccaa     1620

gggaccgaat gctgatgttt gaagaacttt cagatatctt ctcagaccat aataaccatt     1680

tgaccagccg agaactactg atgaaggaag gaacctcaaa atttgcaaac ctggacagca     1740

gtgtgaaaga aaaccagaag cgtacccaga ggcggctgca gctccagaag gacatgggtg     1800

tgatgcaggg aactgtgccc tacctgggca ccttcctgac tgacctgacc atgcttgaca     1860

ctgcccttca ggactacatc gagggtggac tgataaactt tgagaaaagg agaagggaat     1920

ttgaagtgat tgcccagata aagctcttac agtctgcctg caacagctat tgcatgaccc     1980

cagaccaaaa gttcatccag tggttccaga ggcagcagct cctgacagag gaggagagct     2040

atgccctgtc atgtgagatt gaagcagctg ctgacgccag caccacctcg cccaagcctc     2100

ggaagagcat ggtgaagaga ctcagcctac tgtttctagg gtctgacatg atcaccagtc     2160

ccactcccac caaagagcag cccaagtcca ctgccagcgg gagctctggt gaaagcatgg     2220

actctgtcag cgtgtcatcc tgcgagtcga accactcaga ggctgaggag ggctccatta     2280

ctcccatgga cacccctgat gagcctcaaa aaaagctctc tgagtcctcc tcatcctgtt     2340

cttctatcca ttccatggac acaaattcct cagggatgtc ttccttaatc aaccccctct     2400

cctcccctcc gtcctgcaac aacaacccca aaatccacaa gcgctctgtc tcggtgacgt     2460

ccattacctc gactgtgctg cctcctgttt acaaccaaca gaatgaagac acctgcataa     2520

tccgcatcag tgtggaagac aataacggca acatgtacaa gagcatcatg ttgacgagcc     2580

aggataaaac ccccgctgtg atccagagag ccatgctgaa gcacaatctg gactcagacc     2640

ccgccgagga gtacgagctg gtgcaggtca tctcggagga caaagaactt gtgattccag     2700

actcagcaaa tgtcttttat gccatgaaca gccaagtgaa ctttgacttc attttgcgca     2760

aaaagaactc catggaagaa caagtgaaac tgcgtagccg gaccagcttg acgttgccca     2820

ggacagctaa acggggctgc tggagtaaca gacacagcaa aatcaccctc tgaagggagg     2880

gaccagtggc cccttgtttg ccaaaggcag agtggggctg agaaacaggc tgcggtgatt     2940

gcaattacca tccggtgttc gaggatcatt ggtgaagtca gcagatattt attgagttcc     3000

tgtggtgtgc aaagcattat gataggcacc gtggggaaac tggaaatgaa tttgacatga     3060

aaaggatgaa cgattcactg attctctttg actcatttga gactaaaatg cagaattacc     3120

aacatttaaa acatatatat gcacatgtat ttggtatgca tgtgtatcta tataaaaata     3180

tataagaggg actttatggg atagtatgga ctatggaaaa acaaatttgc acaatggcct     3240

gggaagttga ggtcactttt tacagggaaa tagaagaaac tgagaaccta gtctcgtata     3300

ttctgagtaa atggaatcag tcctgggaat agagagtgtc ctttgtgcca gtattacaag     3360

aagcccaaac tttattttta taaagggaga ggatgacttt ctcaatcaag tgccaccaga     3420

taaaaacaac tgcagaggct ggaactgcca caggctgtat gaaaggccac tttggaaagg     3480

gtttggatga gctggtggcc ttcaacctct gcctgcatct gccactttct gctaccctag     3540

ggaggccagg aggagcttcg gaggaccatc gccccactgg tctagccatc atgacacctc     3600

tggaggtgtc aagctcctga aacaagctca tttcagtttc tggcaacccc gtgtatttcc     3660

gttttccccc taaagaacat atcataatca ttgcacaaat aaccatgttc tttggtaatg     3720

aagccagaaa agaaagcgca aaagaatggt gactcatttg gactcttatc tgtcttggaa     3780

tgtcactgct tcattgcctt ctctgattgc cttttgcatg taaaactatg tgtctggagt     3840

cttttgccat ctggatctta gtacctcttt attatgtgca atttattcct caggtgtgga     3900

aatttctact gcaattgact acgtttgatt attttgagct tgtgaaagat ttctgaacag     3960

tgattgtccc gttaatagcc cctcagaaga tgttccctgc tgataacagc atcctatttt     4020

acttactttt atagcattac tgtgcctagt cgtggggaaa gagatggggc tgtatagatt     4080

atctgaatca tttgtctaag aggtacattc ttccagatgg aatcaataac tttttttttt     4140

ccaggttccc gtgcttgcta tcacagtatc attgttaagt gacacttttg tctctcataa     4200

caccatcaca ctcttccttc caagtctgag ctgtgctggg gtttgaacta aaagccatat     4260

gtggaatatt gacatgtgta agaagcactt tcagaatgtt gtccttttta agaaatgatt     4320

ctcaaaatac cagtttttat tccaaaaatt tagagaacaa acccggaata tgaagtgcag     4380

attgtaacat ggagctattt ttttttctta atcccataat acagctccta aaagttgtgt     4440

gggatttgcg ttgcataaat agccatgtga attccacaag aagcaccagg gaaagtttag     4500

agatttgcgg caatggaccg aagaacgggc caggaagtcc tccaatttcc tttggtcttt     4560

ccaggagatt ggactacaca ttgtaaagac tgactgggtt tcaactagtc aaaaagcact     4620

ttcttctgtt ttcaatccct gttcgatttg tgcttctgtg cttgtaggag agatggccag     4680

ggtggcagcc ctcatgcagg ttgaagtata tgtagcctca gcctgatatt cttggtgcga     4740

aggtaaaaaa aaaaaaataa ataaaaccat tggcctggtt gagggcgtga ccaccaagac     4800

atatatgttg tgcccgtgtt catcctgtgt atttatactg tatatgtaga gtctagattt     4860

atatactgca atgtaaaata tatatatatt tacctttttt aaagacaatg gaaattccaa     4920

gtagctaaaa cttagcttca tttatttaat gccactttaa atgtcttaaa tttgtttcct     4980

ggtggacagc cgggtaatgc ttttagctgc tcgcatgctt gtctttctgc atctccatca     5040

tctgtttacc ttttggttaa actaataaac tagtttggga cttggctggc atgtgctgcc     5100

agacccaaag gga                                                        5113


<210>  426
<211>  803
<212>  PRT
<213>  Homo Sapiens

<400>  426

Met Glu Val Lys Pro Val Gly Glu Pro Thr Gln Glu Val Ser Lys Phe 
1               5                   10                  15      


Lys Leu Ser Thr Lys Val Glu Ser Thr Gly His Trp Leu Val Glu Asp 
            20                  25                  30          


His Val Arg Ile Trp Glu Val Leu Lys Thr Glu Glu Ser Ser Ile Gln 
        35                  40                  45              


Asp Trp Gly Glu Glu Val Glu Glu Gly Ala Val Tyr His Val Thr Leu 
    50                  55                  60                  


Lys Arg Val Gln Ile Gln Gln Ala Ala Asn Lys Gly Ala Arg Trp Leu 
65                  70                  75                  80  


Gly Val Glu Gly Asp Gln Leu Pro Pro Gly His Thr Val Ser Gln Tyr 
                85                  90                  95      


Glu Thr Cys Lys Ile Arg Thr Ile Lys Ala Gly Thr Leu Glu Lys Leu 
            100                 105                 110         


Val Glu Asn Leu Leu Thr Ala Phe Gly Asp Asn Asp Phe Thr Tyr Ile 
        115                 120                 125             


Ser Ile Phe Leu Ser Thr Tyr Arg Gly Phe Ala Ser Thr Lys Glu Val 
    130                 135                 140                 


Leu Glu Leu Leu Leu Asp Arg Tyr Gly Asn Leu Thr Ser Pro Asn Cys 
145                 150                 155                 160 


Glu Glu Asp Gly Ser Gln Ser Ser Ser Glu Ser Lys Met Val Ile Arg 
                165                 170                 175     


Asn Ala Ile Ala Ser Ile Leu Arg Ala Trp Leu Asp Gln Cys Ala Glu 
            180                 185                 190         


Asp Phe Arg Glu Pro Pro His Phe Pro Cys Leu Gln Lys Leu Leu Asp 
        195                 200                 205             


Tyr Leu Thr Arg Met Met Pro Gly Ser Asp Pro Glu Arg Arg Ala Gln 
    210                 215                 220                 


Asn Leu Leu Glu Gln Phe Gln Lys Gln Glu Val Glu Thr Asp Asn Gly 
225                 230                 235                 240 


Leu Pro Asn Thr Ile Ser Phe Ser Leu Glu Glu Glu Glu Glu Leu Glu 
                245                 250                 255     


Gly Gly Glu Ser Ala Glu Phe Thr Cys Phe Ser Glu Asp Leu Val Ala 
            260                 265                 270         


Glu Gln Leu Thr Tyr Met Asp Ala Gln Leu Phe Lys Lys Val Val Pro 
        275                 280                 285             


His His Cys Leu Gly Cys Ile Trp Ser Arg Arg Asp Lys Lys Glu Asn 
    290                 295                 300                 


Lys His Leu Ala Pro Thr Ile Arg Ala Thr Ile Ser Gln Phe Asn Thr 
305                 310                 315                 320 


Leu Thr Lys Cys Val Val Ser Thr Ile Leu Gly Gly Lys Glu Leu Lys 
                325                 330                 335     


Thr Gln Gln Arg Ala Lys Ile Ile Glu Lys Trp Ile Asn Ile Ala His 
            340                 345                 350         


Glu Cys Arg Leu Leu Lys Asn Phe Ser Ser Leu Arg Ala Ile Val Ser 
        355                 360                 365             


Ala Leu Gln Ser Asn Ser Ile Tyr Arg Leu Lys Lys Thr Trp Ala Ala 
    370                 375                 380                 


Val Pro Arg Asp Arg Met Leu Met Phe Glu Glu Leu Ser Asp Ile Phe 
385                 390                 395                 400 


Ser Asp His Asn Asn His Leu Thr Ser Arg Glu Leu Leu Met Lys Glu 
                405                 410                 415     


Gly Thr Ser Lys Phe Ala Asn Leu Asp Ser Ser Val Lys Glu Asn Gln 
            420                 425                 430         


Lys Arg Thr Gln Arg Arg Leu Gln Leu Gln Lys Asp Met Gly Val Met 
        435                 440                 445             


Gln Gly Thr Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Thr Met 
    450                 455                 460                 


Leu Asp Thr Ala Leu Gln Asp Tyr Ile Glu Gly Gly Leu Ile Asn Phe 
465                 470                 475                 480 


Glu Lys Arg Arg Arg Glu Phe Glu Val Ile Ala Gln Ile Lys Leu Leu 
                485                 490                 495     


Gln Ser Ala Cys Asn Ser Tyr Cys Met Thr Pro Asp Gln Lys Phe Ile 
            500                 505                 510         


Gln Trp Phe Gln Arg Gln Gln Leu Leu Thr Glu Glu Glu Ser Tyr Ala 
        515                 520                 525             


Leu Ser Cys Glu Ile Glu Ala Ala Ala Asp Ala Ser Thr Thr Ser Pro 
    530                 535                 540                 


Lys Pro Arg Lys Ser Met Val Lys Arg Leu Ser Leu Leu Phe Leu Gly 
545                 550                 555                 560 


Ser Asp Met Ile Thr Ser Pro Thr Pro Thr Lys Glu Gln Pro Lys Ser 
                565                 570                 575     


Thr Ala Ser Gly Ser Ser Gly Glu Ser Met Asp Ser Val Ser Val Ser 
            580                 585                 590         


Ser Cys Glu Ser Asn His Ser Glu Ala Glu Glu Gly Ser Ile Thr Pro 
        595                 600                 605             


Met Asp Thr Pro Asp Glu Pro Gln Lys Lys Leu Ser Glu Ser Ser Ser 
    610                 615                 620                 


Ser Cys Ser Ser Ile His Ser Met Asp Thr Asn Ser Ser Gly Met Ser 
625                 630                 635                 640 


Ser Leu Ile Asn Pro Leu Ser Ser Pro Pro Ser Cys Asn Asn Asn Pro 
                645                 650                 655     


Lys Ile His Lys Arg Ser Val Ser Val Thr Ser Ile Thr Ser Thr Val 
            660                 665                 670         


Leu Pro Pro Val Tyr Asn Gln Gln Asn Glu Asp Thr Cys Ile Ile Arg 
        675                 680                 685             


Ile Ser Val Glu Asp Asn Asn Gly Asn Met Tyr Lys Ser Ile Met Leu 
    690                 695                 700                 


Thr Ser Gln Asp Lys Thr Pro Ala Val Ile Gln Arg Ala Met Leu Lys 
705                 710                 715                 720 


His Asn Leu Asp Ser Asp Pro Ala Glu Glu Tyr Glu Leu Val Gln Val 
                725                 730                 735     


Ile Ser Glu Asp Lys Glu Leu Val Ile Pro Asp Ser Ala Asn Val Phe 
            740                 745                 750         


Tyr Ala Met Asn Ser Gln Val Asn Phe Asp Phe Ile Leu Arg Lys Lys 
        755                 760                 765             


Asn Ser Met Glu Glu Gln Val Lys Leu Arg Ser Arg Thr Ser Leu Thr 
    770                 775                 780                 


Leu Pro Arg Thr Ala Lys Arg Gly Cys Trp Ser Asn Arg His Ser Lys 
785                 790                 795                 800 


Ile Thr Leu 
            


<210>  427
<211>  1077
<212>  DNA
<213>  Homo Sapiens

<400>  427
acgtatatac agagcctccc tggccctcct ggaaagagtc ctggaaagac aaccttcagg       60

tccagccctg gagctggagg agtggagccc cactctgaag acgcagcctt tctccaggtt      120

ctgtctctcc cattctgatt cttgacacca gatgcaggat ggtgtcctct ccctgcacgc      180

aggcaagctc acggacttgc tcccgtatcc tgggactgag ccttgggact gcagccctgt      240

ttgctgctgg ggccaacgtg gcactcctcc ttcctaactg ggatgtcacc tacctgttga      300

ggggcctcct tggcaggcat gccatgctgg gaactgggct ctggggagga ggcctcatgg      360

tactcactgc agctatcctc atctccttga tgggctggag atacggctgc ttcagtaaga      420

gtgggctctg tcgaagcgtg cttactgctc tgttgtcagg tggcctggct ttacttggag      480

ccctgatttg ctttgtcact tctggagttg ctctgaaaga tggtcctttt tgcatgtttg      540

atgtttcatc cttcaatcag acacaagctt ggaaatatgg ttacccattc aaagacctgc      600

atagtaggaa ttatctgtat gaccgttcgc tctggaactc cgtctgcctg gagccctctg      660

cagctgttgt ctggcacgtg tccctcttct ccgcccttct gtgcatcagc ctgctccagc      720

ttctcctggt ggtcgttcat gtcatcaaca gcctcctggg ccttttctgc agcctctgcg      780

agaagtgaca ggcagaacct tcacttgcaa gcatgggtgt tttcatcatc ggctgtcttg      840

aatcctttct acaaggagtg ggtacgaatt ataaacaaac ttccccttta ggtatccctg      900

gagtaataat gacaacaaaa ttcactgcag gtcggtggaa tgatagaatg cattttaaat      960

cacattgtaa acttccaggt gatccatgga taggataaat aactaagtta ttataattgt     1020

ttaggaattt atagtccata aaatatcctc cagccaggga aaaaaaaaaa aaaaaaa        1077


<210>  428
<211>  209
<212>  PRT
<213>  Homo Sapiens

<400>  428

Met Val Ser Ser Pro Cys Thr Gln Ala Ser Ser Arg Thr Cys Ser Arg 
1               5                   10                  15      


Ile Leu Gly Leu Ser Leu Gly Thr Ala Ala Leu Phe Ala Ala Gly Ala 
            20                  25                  30          


Asn Val Ala Leu Leu Leu Pro Asn Trp Asp Val Thr Tyr Leu Leu Arg 
        35                  40                  45              


Gly Leu Leu Gly Arg His Ala Met Leu Gly Thr Gly Leu Trp Gly Gly 
    50                  55                  60                  


Gly Leu Met Val Leu Thr Ala Ala Ile Leu Ile Ser Leu Met Gly Trp 
65                  70                  75                  80  


Arg Tyr Gly Cys Phe Ser Lys Ser Gly Leu Cys Arg Ser Val Leu Thr 
                85                  90                  95      


Ala Leu Leu Ser Gly Gly Leu Ala Leu Leu Gly Ala Leu Ile Cys Phe 
            100                 105                 110         


Val Thr Ser Gly Val Ala Leu Lys Asp Gly Pro Phe Cys Met Phe Asp 
        115                 120                 125             


Val Ser Ser Phe Asn Gln Thr Gln Ala Trp Lys Tyr Gly Tyr Pro Phe 
    130                 135                 140                 


Lys Asp Leu His Ser Arg Asn Tyr Leu Tyr Asp Arg Ser Leu Trp Asn 
145                 150                 155                 160 


Ser Val Cys Leu Glu Pro Ser Ala Ala Val Val Trp His Val Ser Leu 
                165                 170                 175     


Phe Ser Ala Leu Leu Cys Ile Ser Leu Leu Gln Leu Leu Leu Val Val 
            180                 185                 190         


Val His Val Ile Asn Ser Leu Leu Gly Leu Phe Cys Ser Leu Cys Glu 
        195                 200                 205             


Lys 
    


<210>  429
<211>  9306
<212>  DNA
<213>  Homo Sapiens

<400>  429
gggttcggag cgcgaagccg ccgctgggtc ctcggcgcgc cccgcgtctg cgcttgctgc       60

cgcgccccgg tcggcgcgct gggagttcca gccatgctct tctggcacac gcagcccgag      120

cactacaacc agcacaactc cggcagctac ctgcgtgatg tgctcgctct gcccatcttc      180

aagcaggagg aaccccagct gtcccccgag aacgaggccc gcctgccacc cctgcaatat      240

gtgttgtgtg ctgccacgtc cccagccgtg aagctgcatg aagagacgct gacctacctc      300

aaccaaggtc agtcttatga aatccgacta ctggagaatc ggaagctggg agactttcaa      360

gatctgaaca caaaatatgt caagagcatc atccgtgtgg tcttccatga ccgccggctg      420

cagtatacgg agcaccagca gctggagggc tggcggtgga gtcggccagg ggaccggatc      480

ctggacatcg atattccact gtctgttggt atcttggacc ccagggccag cccgacccag      540

ctgaatgcag tcgagttttt gtgggaccct gcgaagagag cttctgcatt cattcaggta      600

cactgcatca gcacagaatt cacccccagg aagcacgggg gcgagaaggg agtgcccttt      660

cgagtccaga ttgacacgtt taagcagaac gagaatgggg agtacacgga gcacctgcac      720

tcagccagct gccagatcaa ggtgttcaag ccgaagggag ccgatcggaa acagaagact      780

gaccgggaga agatggagaa aagaactgcc caagagaagg agaaatacca gccgtcctat      840

gaaaccacca tcctcacaga gtgctctcca tggcccgacg tggcctacca ggtgaacagc      900

gccccgtccc caagctacaa tggttctcca aacagctttg gcctcggcga aggcaacgcc      960

tctccgaccc acccggtgga ggccctgccc gtgggcagtg accacctgct cccatcagct     1020

tcgatccagg atgcccagca gtggcttcac cgcaacaggt tctcgcagtt ctgccggctc     1080

tttgccagct tctcaggtgc tgacttgctg aagatgtccc gagatgattt ggtccagatc     1140

tgtggtcccg cagatgggat ccggctcttc aacgccatca aaggccggaa tgtgaggcca     1200

aagatgacca tttatgtctg tcaggagctg gagcagaatc gagtgcccct gcagcagaag     1260

cgggacggca gtggagacag caacctgtct gtgtaccacg ccatcttcct ggaagagctg     1320

accaccttgg agctgattga gaagatcgcc aacctgtaca gcatctcccc ccagcacatc     1380

caccgagtct accggcaggg ccccacgggc atccatgtgg tggtgagcaa cgagatggtg     1440

cagaacttcc aagatgaatc ctgttttgtc ctcagcacaa ttaaagctga gagcaatgat     1500

ggctaccaca tcatcctgaa atgtggactc tgagcagcag tggacctcat acctgtctcc     1560

agctcccagc cctgtggatc cccgtggatg tagacattgc cccactgtaa gctgtggcct     1620

caccaggcaa gctgaggcca ggagggaccc tgcccagtct gtgaaagcta cagagcacca     1680

accagcagaa gcctgtggac accaagtacg gtgtacagaa agccagtggc tcctttctcc     1740

cttcctcttg gcctccagat tttgaatggt tccttgttct tttctattgg tccaaccctg     1800

acgttctaaa agggcaaaca gtggagacgt ctgctctgaa atccctcatc ccttagttgg     1860

aagctgattg ggtatcttgg tgctgcctgt attggtccct tctgaccact ctcctgcctc     1920

cagagaaagc tctgcttcac cctggaagct ggtaccttta cctcctcctc tgggagttgg     1980

ctgcatggcc agcactgccg acttgatggg agcagtttgc cctcattctc ctgtttcagg     2040

tttgcttccc ttctcagtga ccctggtgag catccgcctt tcctgttctt ggatgaattg     2100

atgggagtgg ggctattctg tgccttctac ctctttcttc tctacgttgt ttctaaggat     2160

ctgctgctgc ggaacccaaa gatgtgctcc tgtctctgca ctggcgcatt ggcatggtag     2220

atgccacaat gtatgtgcac ggcctttctc agagacatta gttctgaggc cctttgtggg     2280

gaggttaggg ggatggtaat agaaaaagac tattttattt cctggcaatc acgggtaagg     2340

aggattagga atgagtattc cattcctagg tgtcatcaga tgaccttgac caccacaata     2400

ccaggccctc ttggatggac ttatagaaag ttagagaaga ccttgttgaa ccgctgctaa     2460

acttgccaca ggagcgatgt gttttctctg agtgcccctc acttacatgt ttatctttgt     2520

ttgtagaggc tatgtttagg atattttgcc tgcatcagaa tgggtgcatc atctttctta     2580

atggcctaac tatcgggaaa tttgagtgtc agtaactgtg gtagactcag aaattcgtct     2640

ttgtcttgcc tctggttcct gggatccagt gatctctact ggcccagggc ttcagctctt     2700

ggttaattta ggttcatggg gaaccctctg accacctgaa tgggatgtca tagcttctaa     2760

atggagcttc tgtggaatga agtgctagac tgaaggacta ccagaataaa acagggtcta     2820

caatggggag aacttgtttt atagatgagg aaaccaaggc tcagaggggc aaagtcacct     2880

gcatggtagc acatagtgat agggtagcga tataaattta tcatataaac caggacatct     2940

cggaataaaa ggggctctgt tagtcattat gttgggtaat agccgtggca ttcctacaga     3000

acagagtgag gacaggctcc tgattcctct tccttcttta gaggagaagc ggggagtggg     3060

ttaactaaca gctttattga gatgtcattc acatgccatt cagtttaccc attgctagtg     3120

tccaattgta ttcacagaac caccatcaat tcacagaatt acagtcaacg ttggtacatt     3180

ttcatcaccc ccagtaaaac cccgtaccct tggtctgtca ctcctgcttt cctaactcct     3240

gcagtccaag gcagccatga atctactttc tatgtaagat taacctactc tggacatttc     3300

atatatctgg aatcatgtga tatctctttt gtgactggct tcttccactg aatgttttct     3360

agggccgtcc aagttgagga tgtatcagta cttcattctt ttgtattgct gaataatact     3420

tcattgtata gatagaccac atttgtttat tgattcatca gttgatggac atttgtgtgt     3480

ttttactttt tggctactct gaatgatgct gctatgaaca tatttctaca agattttgtg     3540

tggacatatg ttttcatttc ttttagcaat atacatagga gtggaattgc taggtcttac     3600

agtaactccg tgttttaact ttttgagaaa ctgccagact gttttctata gcagctgtac     3660

cattttacat tcccaccagc aatgtatcca ggtttcaatt tgtctacatc ctcatcaaca     3720

cttgctatta tctgtctttt tgcttttagc atcctaatga gtatgaaatg ctatcttgtg     3780

gttttgattt gcattcccct gatggcaact gatgctgagt gtcttttcct gtgcttacgg     3840

gccatgcgta tttctttgga gaaaggtcta tccaggtcct ttgcctattt ttaattgagt     3900

tgtctttttt tttttaagtt ttctgttttc ctaaccacta gactaccagg gatgagcctt     3960

ctttttatta ttgagttggg tgagctattt gtatattcta gacgccagtc ttttatcagg     4020

tatatgactg gtaaaaatgt tctccccttc tgtggattgt tttcagtttc ttgttggtgt     4080

cctttgagac acaaaacttt ttaactttga tgatttccaa gatacgtatt ttttttctat     4140

tgtcacttgt gcttttggtg ccatatctag aaaaccattg cctaatccaa ggtcaagaag     4200

attaatgcct gtgttttctt ctaagaacta tacttttagt tctcacaatg gtctttgatc     4260

catttcgagt atatttttat atatgatgtg atgtaggggt ccagcttcat tcttttgctt     4320

gtggatctcc acttgtccca ctgctgatta ttgagaaaaa tatcctttct ccacggaatt     4380

gtcttggcat ccttgctaaa ggcctctgct tcttactgga tcttctttcc tgggacatgg     4440

tgtcgttggg aagcttacct tttttttttt tttacttagt ctgtgtttgg ttccaccagt     4500

tttatgctgc ctttctactc tgttcttgct gtctccctct ttacctgagt caacggtact     4560

gagtcctatc tctctctgat gttccccagt cttccttggt gcatgttcta gctccacaca     4620

ctagtccttg gaggaaggtt gagaccaatg atttcctgtt atgagtcatg aggaaactga     4680

atcacctaga agtggaataa tgtgctcagg gtcaccatag cccattagtg gaaggaccag     4740

gactagacct ttagtcttct gaggtccagc cccttaggct gtctgtcatc actgtaccca     4800

agtgatgtca ctaccaaggc caaatgatgg tgggctaaat tttaattctc aaaagtgtag     4860

gaggctaata ttgtcttcta agttccaaaa gaagatgtaa taaaagtctg ttaccttaag     4920

tgtgctatta gtagagtctt ccatttttct ggcatgcccc tggcatctgc tcttcttacc     4980

ttctcgtggt tgtagttaaa gcttatagct tatgaaagaa tagaaaataa taaataccaa     5040

aaaaaagtac acatggtaat ttggtaccaa aatatctcag ctgcctaatt tagcagctca     5100

tcccttccac aggggtcaga tgagctaaag ctccaggttt tatttttcat ttgattgaca     5160

tacagaaaag ccatagccct tcccacagct gtccagggtc tttcctgtga gtccggaggt     5220

gctggcctat tgagcaggac agctcttccc agggcattcc caccaacctg tggcttctga     5280

actgtagctt ctttttacag tgaaccccag agggaaataa gacagacaca tgtgctcagg     5340

ccaccatctt gaactggaag cccaaagctg agttccttac tcttaggtcg tcacggtttt     5400

tgcggggtat ctgcaaggtt gagataaacc ctttcctgtt taccaggttg tcctttctgg     5460

atgaagggac agaggctgtt gaatggagga ataataggtt tgctggagga ggggcatggt     5520

atgcctgtgg aaaggacagg atggggtggg gaggtcgagg ctttgacttg gggtcctaaa     5580

caaaggtcag gtgttgccct agtgacctct tgcccagaca gcccagagcc ccttacacag     5640

agctattaac ctagggaagg ctttaccagc agtggactgg agccagccag ggtcacaagt     5700

ttccaagtcc agcattgctt caggggctgg cctgagtaac tgaagatctg aaaatcatta     5760

acaagtcgat gaaataaacg gaaaagcctc ttaggctgtt gtcagtggag cagagggaga     5820

aagtccctag gcgctcagag ggggtgagaa agcagtggat gattgggcgg gggtggggga     5880

ttagatgttg acactgcctg gggtgtagga agaggaacag agaacccaga gtcagggtcc     5940

tagatcccag accctcgctc agtatgagtc tctttgcctc tctgggtctc tatctcctcc     6000

tcttacaaat acaggcttgg tgatctctga agatggcacc aacctgccat gaaatgaatc     6060

tgaggggttt tcccattttt ccctccatca aaatcgtaca aaaagctgga cgtggtggcc     6120

catgcctcta atcctagcat tttgggaggc cgaggtggga gaatcacttg acgccaagag     6180

ttcgagacca gcctgggcat cgtagtgaga ctccatctct gtctttttga aaataaaaaa     6240

tctttgaaaa ttgcacaaca ggcaggagac ctttacgtgt gcccatcctg gttgtacaca     6300

gtgccaccag tgctcctgca gtgcaaggcg gcatgcttct tgacatgggt cagattgtgt     6360

ccatcgtgtc tttgggaatc agccctagct cctaactggg ctgactactt cctccgcaaa     6420

cttatggggg ctcccagata ttccttgcca gccaggggcc agacacagtg caggcacagt     6480

ctgtgtcatt ggtgcacatg tgcgtgttta catgtgtacc tgggttcctt cccttgccca     6540

tgaatttgcc atgagcacag ccagaagcag cctcagcttg gcaaggtgtg gagatgactg     6600

ctgttccctt cgcatttggg gaaaacaggc tccctcggta gctcgatgat cctcttttga     6660

tcttgtgtga cctcctggag agtggatgaa gctggtggcc ttagcttttc tagacagtgt     6720

aagtggcact gggcaaggcc cccagagcag ggcaaggtct ctagagcggg tctcccacat     6780

gactggcttc acacaggcac ttccgctcgg gttgcatgct ctgtgtcatc ttaccggtcc     6840

agggttgcag gtaggaaatg tttgtaccct cttctgattg ccacctcctt cccatcgccc     6900

cttagggaca gggcttgagg gccagtgagg cgctggtcag gcaccccagg cctccttggg     6960

acctgcccag gggcaccctg agagctcctg aaacccccac ttagcttcca gacctttctg     7020

caaaagctcc tcctggcttt cctccctccc ccaatctatg ggtcacagct aacagatctg     7080

agggcaactg ctgtgctagt ggccagggct gcacctgcca tccccggctc tgccacttta     7140

gggccttcta gaggcagtgt ccttaggaag tagctctgag gcatgggttt tctgctcctg     7200

tgcagggcag ctgatgggat aaggtgggga aggacggtca gtgcttgggc cccagctggc     7260

cagcctggcg atggggaaac caaaccatgt cccccagcga agggccagag tgggaacctg     7320

tcctcatgcc cttcgtcctg aggagccctg aggtgggcag caggggccag gggaagtttt     7380

caggccttca tcaaagagaa caacatcctc agctccgcac ccctcatcct gtatcagcac     7440

ttaccggtgt gtgactgccc ttgtcagcta gcatacggtg ggcccacctg gcccactggc     7500

tgtttatgcc actgatttat gatagggaat attatctttg aacccaatga agtgttttct     7560

cccccatcac aaaaaaaaaa attcttattt ttagtagaca tgtatttacc aaaaatatgt     7620

actcaattat tgtattttgg attttatcaa tttaaaaatt gtggaaattt gtttgctctt     7680

acgccaacat aatattgatt ttgcctcttg gctctgaaag cccaaaatat ttaccgtcta     7740

gcccgttaca gaaaaagtct gctgactact gagccagacc tccattacct ccatccctgt     7800

tggattattt aaagaaagcc tcagacagta agggcttttt taaaagaata aaatgacttg     7860

gtttgcgctt ggaagcaggg gaagcattca gatgagcggt ttctgcatta accctgccta     7920

tcacgcatct cgtgtcctgt gtggctggcg agcccccctt ggaaggttct ggtgcttcag     7980

ctggctcctg cagagtccac cccgcctcgt ggtgggaatg cagagccctt tgctttcctt     8040

cttgccgcct gcttcctgtt cctggggacc cgctgggcct ttggtctgca tcccctggcc     8100

aggtccctca gggttgatgc gtggagaagg actttgagca gtggtgggca gcagtggcct     8160

cctggccagc tcacactctt gtcctgggag gggcagcctg atctcacctc cacctagtac     8220

cttggggact gaggaccttt tggcttctct ggagcctgca agcctcttcc catgtgtcca     8280

gctgctcttc ctgctacaaa ggggactgct cacagtggcc tcagcttggt ggttttgagg     8340

ggccgccccc cggccctcca taagggtatc ctgggcctga gaattctgca tctgccattg     8400

gaggatggac agcctcaaat ggaaggagtc ccacgggaga tgggtccgag gtccggctgt     8460

ggccatccag ccccctgtgg cttgtccagc ctctgtgcac ccctggtgtc ttcactccag     8520

gggcagacag cagccactgc agttcctttc ttcgtgagta acagtagtga tagcagctgg     8580

ggctaacagg ctaggctttg tgttctgcgc atttggtcag cttctcactc gatcctccct     8640

aaagcaatgg ggaggccccc actagcccag ttttcaggaa gtcaactggg aggttagatg     8700

ggggccaggg tcccacagct actgatggcc cgagccaggt tgagcttcct ggtgtccagt     8760

ccggatccca cttgcagatc tcatgctctc agataggtgg gacaagttct tttgtcacag     8820

tgctggctct gtcctgaggc ctcattgctg gctgggtgtg ctctgctggg aaaagctttg     8880

cggggcttgc ttggttaacc acagaagaga aggggactgt ttggggtgcc tctctgcagc     8940

ctccccgtgc tgggtggaag cacggttact gtgttctcta atgttcatgt atttaaaatg     9000

atttctttct aaagatgtaa cctccacacc tttctccaga ttgggtgact cttttctaaa     9060

ggtggtggga gtatctgtcg gggtggtgtg gcccttggat gggtcaggtg ggtgtgagag     9120

gtcctgggga ggtgggcgtt gagctcaaag ttgtcctact gccatgtttt tgtacctgaa     9180

ataaagcata ttttgcactt gttactgtac catagtgcgg acgagaagtc tgtatgtggg     9240

atctgtgctt gggttagaat gcaaataaaa ctcacatttg taagaaaaaa aaaaaaaaaa     9300

aaaaaa                                                                9306


<210>  430
<211>  479
<212>  PRT
<213>  Homo Sapiens

<400>  430

Met Leu Phe Trp His Thr Gln Pro Glu His Tyr Asn Gln His Asn Ser 
1               5                   10                  15      


Gly Ser Tyr Leu Arg Asp Val Leu Ala Leu Pro Ile Phe Lys Gln Glu 
            20                  25                  30          


Glu Pro Gln Leu Ser Pro Glu Asn Glu Ala Arg Leu Pro Pro Leu Gln 
        35                  40                  45              


Tyr Val Leu Cys Ala Ala Thr Ser Pro Ala Val Lys Leu His Glu Glu 
    50                  55                  60                  


Thr Leu Thr Tyr Leu Asn Gln Gly Gln Ser Tyr Glu Ile Arg Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Lys Leu Gly Asp Phe Gln Asp Leu Asn Thr Lys Tyr Val 
                85                  90                  95      


Lys Ser Ile Ile Arg Val Val Phe His Asp Arg Arg Leu Gln Tyr Thr 
            100                 105                 110         


Glu His Gln Gln Leu Glu Gly Trp Arg Trp Ser Arg Pro Gly Asp Arg 
        115                 120                 125             


Ile Leu Asp Ile Asp Ile Pro Leu Ser Val Gly Ile Leu Asp Pro Arg 
    130                 135                 140                 


Ala Ser Pro Thr Gln Leu Asn Ala Val Glu Phe Leu Trp Asp Pro Ala 
145                 150                 155                 160 


Lys Arg Ala Ser Ala Phe Ile Gln Val His Cys Ile Ser Thr Glu Phe 
                165                 170                 175     


Thr Pro Arg Lys His Gly Gly Glu Lys Gly Val Pro Phe Arg Val Gln 
            180                 185                 190         


Ile Asp Thr Phe Lys Gln Asn Glu Asn Gly Glu Tyr Thr Glu His Leu 
        195                 200                 205             


His Ser Ala Ser Cys Gln Ile Lys Val Phe Lys Pro Lys Gly Ala Asp 
    210                 215                 220                 


Arg Lys Gln Lys Thr Asp Arg Glu Lys Met Glu Lys Arg Thr Ala Gln 
225                 230                 235                 240 


Glu Lys Glu Lys Tyr Gln Pro Ser Tyr Glu Thr Thr Ile Leu Thr Glu 
                245                 250                 255     


Cys Ser Pro Trp Pro Asp Val Ala Tyr Gln Val Asn Ser Ala Pro Ser 
            260                 265                 270         


Pro Ser Tyr Asn Gly Ser Pro Asn Ser Phe Gly Leu Gly Glu Gly Asn 
        275                 280                 285             


Ala Ser Pro Thr His Pro Val Glu Ala Leu Pro Val Gly Ser Asp His 
    290                 295                 300                 


Leu Leu Pro Ser Ala Ser Ile Gln Asp Ala Gln Gln Trp Leu His Arg 
305                 310                 315                 320 


Asn Arg Phe Ser Gln Phe Cys Arg Leu Phe Ala Ser Phe Ser Gly Ala 
                325                 330                 335     


Asp Leu Leu Lys Met Ser Arg Asp Asp Leu Val Gln Ile Cys Gly Pro 
            340                 345                 350         


Ala Asp Gly Ile Arg Leu Phe Asn Ala Ile Lys Gly Arg Asn Val Arg 
        355                 360                 365             


Pro Lys Met Thr Ile Tyr Val Cys Gln Glu Leu Glu Gln Asn Arg Val 
    370                 375                 380                 


Pro Leu Gln Gln Lys Arg Asp Gly Ser Gly Asp Ser Asn Leu Ser Val 
385                 390                 395                 400 


Tyr His Ala Ile Phe Leu Glu Glu Leu Thr Thr Leu Glu Leu Ile Glu 
                405                 410                 415     


Lys Ile Ala Asn Leu Tyr Ser Ile Ser Pro Gln His Ile His Arg Val 
            420                 425                 430         


Tyr Arg Gln Gly Pro Thr Gly Ile His Val Val Val Ser Asn Glu Met 
        435                 440                 445             


Val Gln Asn Phe Gln Asp Glu Ser Cys Phe Val Leu Ser Thr Ile Lys 
    450                 455                 460                 


Ala Glu Ser Asn Asp Gly Tyr His Ile Ile Leu Lys Cys Gly Leu 
465                 470                 475                 


<210>  431
<211>  4488
<212>  DNA
<213>  Homo Sapiens

<400>  431
agcgagagcc acaagccaca gcgctgagct gcaggcgcgg cgaaacttcc ctctacccgc       60

ccggcccgcg gcgcgcaccg ttggcgctgg acgcttcctc cttggaagcg cctctccctc      120

agttatggag aaaacttgta tagatgcact tcctcttact atgaattctt cagaaaagca      180

agagactgta tgtatttttg gaactggtga ttttggaaga tcactgggat tgaaaatgct      240

ccagtgtggt tattctgttg tttttggaag tcgaaacccc cagaagacca ccctactgcc      300

cagtggtgca gaagtcttga gctattcaga agcagccaag aagtctggca tcataatcat      360

agcaatccac agagagcatt atgattttct cacagaatta actgaggttc tcaatggaaa      420

aatattggta gacatcagca acaacctcaa aatcaatcaa tatccagaat ctaatgcaga      480

gtaccttgct catttggtgc caggagccca cgtggtaaaa gcatttaaca ccatctcagc      540

ctgggctctc cagtcaggag cactggatgc aagtcggcag gtgtttgtgt gtggaaatga      600

cagcaaagcc aagcaaagag tgatggatat tgttcgtaat cttggactta ctccaatgga      660

tcaaggatca ctcatggcag ccaaagaaat tgaaaagtac cccctgcagc tatttccaat      720

gtggaggttc cccttctatt tgtctgctgt gctgtgtgtc ttcttgtttt tctattgtgt      780

tataagagac gtaatctacc cttatgttta tgaaaagaaa gataatacat ttcgtatggc      840

tatttccatt ccaaatcgta tctttccaat aacagcactt acactgcttg ctttggttta      900

cctccctggt gttattgctg ccattctaca actgtaccga ggcacaaaat accgtcgatt      960

cccagactgg cttgaccact ggatgctttg ccgaaagcag cttggcttgg tagctctggg     1020

atttgccttc cttcatgtcc tctacacact tgtgattcct attcgatatt atgtacgatg     1080

gagattggga aacttaaccg ttacccaggc aatactcaag aaggagaatc catttagcac     1140

ctcctcagcc tggctcagtg attcatatgt ggctttggga atacttgggt tttttctgtt     1200

tgtactcttg ggaatcactt ctttgccatc tgttagcaat gcagtcaact ggagagagtt     1260

ccgatttgtc cagtccaaac tgggttattt gaccctgatc ttgtgtacag cccacaccct     1320

ggtgtacggt gggaagagat tcctcagccc ttcaaatctc agatggtatc ttcctgcagc     1380

ctacgtgtta gggcttatca ttccttgcac tgtgctggtg atcaagtttg tcctaatcat     1440

gccatgtgta gacaacaccc ttacaaggat ccgccagggc tgggaaagga actcaaaaca     1500

ctagaaaaag cattgaatgg aaaatcaata tttaaaacaa agttcaattt agctggattt     1560

ctgaactatg gttttgaatg tttaaagaag aatgatgggt acagttagga aagttttttt     1620

cttacaccgt gactgaggga aacattgctt gtctttgaga aattgactga catactggaa     1680

gagaacacca ttttatctca ggttagtgaa gaatcagtgc aggtccctga ctcttatttt     1740

cccagaggcc atggagctga gattgagact agccttgtgg tttcacacta aagagtttcc     1800

ttgttatggg caacatgcat gacctaatgt cttgcaaaat ccaatagaag tattgcagct     1860

tccttctctg gctcaagggc tgagttaagt gaaaggaaaa acagcacaat ggtgaccact     1920

gataaaggct ttattaggta tatctgagga agtgggtcac atgaaatgta aaaagggaat     1980

gaggtttttg ttgttttttg gaagtaaagg caaacataaa tattaccatg atgaattcta     2040

gtgaaatgac cccttgactt tgcttttctt aatacagata tttactgaga ggaactattt     2100

ttataacaca agaaaaattt acaattgatt aaaagtatcc atgtcttgga tacatacgta     2160

tctatagagc tggcatgtaa ttcttcctct ataaagaata ggtataggaa agactgaata     2220

aaaatggagg gatatcccct tggatttcac ttgcattgtg caataagcaa agaagggttg     2280

ataaaagttc ttgatcaaaa agttcaaaga aaccagaatt ttagacagca agctaaataa     2340

atattgtaaa attgcactat attaggttaa gtattattta ggtattataa tatgctttgt     2400

aaattttata ttccaaatat tgctcaatat ttttcatcta ttaaattaat ttctagtgta     2460

aataagtagc ttctatatct gtcttagtct attataattg taaggagtaa aattaaatga     2520

atagtctgca ggtataaatt tgaacaatgc atagatgatc gaaaattacg gaaaatcata     2580

gggcagagag gtgtgaagat tcatcattat gtgaaatttg gatctttctc aaatccttgc     2640

tgaaatttag gatggttctc actgtttttc tgtgctgata gtaccctttc caaggtgacc     2700

ttcaggggga ttaaccttcc tagctcaagc aatgagctaa aaggagcctt atgcatgatc     2760

ttcccacata tcaaaataac taaaaggcac tgagtttggc atttttctgc ctgctctgct     2820

aagacctttt ttttttttta ctttcattat aacatattat acatgacatt atacaaaaat     2880

gattaaaata tattaaaaca acatcaacaa tccaggatat ttttctataa aactttttaa     2940

aaataattgt atctatatat tcaattttac atcctttttc aaaggctttg tttttctaaa     3000

ggctttgttt tcctttttat tatttttttc ttttttattt ttttgagaca gtcttgctct     3060

gtcgctcagg ctggagtgca gtggcacgat ctcagctcac tgcaacctcc tcctcccagg     3120

ttcaagtgat tcttgttcat cagcctcccg agtagctggg actacaggca tgtgccacta     3180

tgcccagcta atttttgtac ttttagtaga gacagggttt caccacattg gtcaggctgg     3240

tcttgaaatg ctggcgtcaa gtgatctgcc tgcctccgcc tcacaaagca ctgggattac     3300

aggcatgaat ctggccttac gtaatatatt ttcttaatgg ctgcataata tcacatcaaa     3360

taggcatttt tcaaacctct ttccttatta aacatgtaga ctatatccat tttttactaa     3420

aataaataac atttcagata atatctttgc actgataatg ttgccaagcc atttctaaag     3480

tgaccttatc aatttaatta ccattggatg agggtgttgc tttcatcgca ccattgtaga     3540

ttgtcttttt tatttcaatt tgcgtttatt tataactggt tgcaaaggta cacagaacac     3600

acgctccttc aacttatctt tgataaaccc aagcaaggat acaaaaagtt ggacgacatt     3660

gagtagagtc atggtatacg gtgctgaccc tacagtatca gtggaaaaga taaggaaaat     3720

gtcactactc acctatgtta tgcaaaacag ttaggtgtgc tggggctgga tactgctctt     3780

ttacttgagc attggttgat taaagtttag gtaccatcca ggctggtcta gagaagtctt     3840

tggagttaac catgctcttt ttgttaaaga agagagtaat gtgtttatcc tggctcatag     3900

tccgtcaccg aaaatagaaa atgccatcca taggtaaaat gctgacctat agaaaaaaat     3960

gaactctact tttatagcct agtaaaaatg ctctacctga gtagttaaaa gcaattcatg     4020

aagcctgaag ctaaagagca ctctgatggt tttggcataa tagctgcatt tccagacctg     4080

acctttggcc ccaaccacaa gtgctccaag ccccaccagc tgaccaaaga aagcccaagt     4140

tctccttctg tccttcccac aacctccctg ctcccaaaac tatgaaatta atttgaccat     4200

attaacacag ctgactcctc cagtttactt aaggtagaaa gaatgagttt acaacagatg     4260

aaaataagtg ctttgggcga actgtattcc ttttaacaga tccaaactat tttacattta     4320

aaaaaaaagt taaactaaac ttctttactg ctgatatgtt tcctgtattc tagaaaaatt     4380

tttacacttt cacattattt ttgtacactt tccccatgtt aagggatgat ggcttttata     4440

aatgtgtatt cattaaatgt tactttaaaa ataaaaaaaa aaaaaaaa                  4488


<210>  432
<211>  459
<212>  PRT
<213>  Homo Sapiens

<400>  432

Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser 
1               5                   10                  15      


Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Gly Ile Ile Ile Ile Ala 
65                  70                  75                  80  


Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu 
                85                  90                  95      


Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr 
                165                 170                 175     


Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala 
        195                 200                 205             


Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Leu Thr Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asp Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Leu Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Gly Asn Leu Thr Val Thr Gln Ala Ile Leu Lys Lys Glu Asn Pro 
                325                 330                 335     


Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu 
                405                 410                 415     


Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val 
            420                 425                 430         


Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His 
    450                 455                 


<210>  433
<211>  1083
<212>  DNA
<213>  Homo Sapiens

<400>  433
atggacccag aagaaacttc agtttatttg gattattact atgctacgag cccaaactct       60

gacatcaggg agacccactc ccatgttcct tacacctctg tcttccttcc agtcttttac      120

acagctgtgt tcctgactgg agtgctgggg aaccttgttc tcatgggagc gttgcatttc      180

aaacccggca gccgaagact gatcgacatc tttatcatca atctggctgc ctctgacttc      240

atttttcttg tcacattgcc tctctgggtg gataaagaag catctctagg actgtggagg      300

acgggctcct tcctgtgcaa agggagctcc tacatgatct ccgtcaatat gcactgcagt      360

gtcctcctgc tcacttgcat gagtgttgac cgctacctgg ccattgtgtg gccagtcgta      420

tccaggaaat tcagaaggac agactgtgca tatgtagtct gtgccagcat ctggtttatc      480

tcctgcctgc tggggttgcc tactcttctg tccagggagc tcacgctgat tgatgataag      540

ccatactgtg cagagaaaaa ggcaactcca attaaactca tatggtccct ggtggcctta      600

attttcacct tttttgtccc tttgttgagc attgtgacct gctactgttg cattgcaagg      660

aagctgtgtg cccattacca gcaatcagga aagcacaaca aaaagctgaa gaaatctata      720

aagatcatct ttattgtcgt ggcagccttt cttgtctcct ggctgccctt caatactttc      780

aagttcctgg ccattgtctc tgggttgcgg caagaacact atttaccctc agctattctt      840

cagcttggta tggaggtgag tggacccttg gcatttgcca acagctgtgt caaccctttc      900

atttactata tcttcgacag ctacatccgc cgggccattg tccactgctt gtgcccttgc      960

ctgaaaaact atgactttgg gagtagcact gagacatcag atagtcacct cactaaggct     1020

ctctccacct tcattcatgc agaagatttt gccaggagga ggaagaggtc tgtgtcactc     1080

taa                                                                   1083


<210>  434
<211>  360
<212>  PRT
<213>  Homo Sapiens

<400>  434

Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr 
1               5                   10                  15      


Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr 
            20                  25                  30          


Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val 
        35                  40                  45              


Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser 
    50                  55                  60                  


Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe 
65                  70                  75                  80  


Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu 
                85                  90                  95      


Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met 
            100                 105                 110         


Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe 
    130                 135                 140                 


Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile 
145                 150                 155                 160 


Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu 
                165                 170                 175     


Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys 
            180                 185                 190         


Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu 
        195                 200                 205             


Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala 
    210                 215                 220                 


His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile 
225                 230                 235                 240 


Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro 
                245                 250                 255     


Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu 
            260                 265                 270         


His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly 
        275                 280                 285             


Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile 
    290                 295                 300                 


Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys 
305                 310                 315                 320 


Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His 
                325                 330                 335     


Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg 
            340                 345                 350         


Arg Arg Lys Arg Ser Val Ser Leu 
        355                 360 


<210>  435
<211>  4390
<212>  DNA
<213>  Homo Sapiens

<400>  435
gagttggggc cagctcccca cccccaagag gccccacatt ccgggccagc agcccagaaa       60

gtccctcccc gcaggcggag acagccccaa gaagtcgacg ccccggtccc gccgcccggc      120

cactacccag agggctgccg ccgcctctcc aagttcttgt ggcccccgcg gtgcggagta      180

tggggcgctg atggccatgg agggctactg gcgcttcctg gcgctgctgg ggtcggcact      240

gctcgtcggc ttcctgtcgg tgatcttcgc cctcgtctgg gtcctccact accgagaggg      300

gcttggctgg gatgggagcg cactagagtt taactggcac ccagtgctca tggtcaccgg      360

cttcgtcttc atccagggca tcgccatcat cgtctacaga ctgccgtgga cctggaaatg      420

cagcaagctc ctgatgaaat ccatccatgc agggttaaat gcagttgctg ccattcttgc      480

aattatctct gtggtggccg tgtttgagaa ccacaatgtt aacaatatag ccaatatgta      540

cagtctgcac agctgggttg gactgatagc tgtcatatgc tatttgttac agcttctttc      600

aggtttttca gtctttctgc ttccatgggc tccgctttct ctccgagcat ttctcatgcc      660

catacatgtt tattctggaa ttgtcatctt tggaacagtg attgcaacag cacttatggg      720

attgacagag aaactgattt tttccctgag agatcctgca tacagtacat tcccgccaga      780

aggtgttttc gtaaatacgc ttggccttct gatcctggtg ttcggggccc tcattttttg      840

gatagtcacc agaccgcaat ggaaacgtcc taaggagcca aattctacca ttcttcatcc      900

aaatggaggc actgaacagg gagcaagagg ttccatgcca gcctactctg gcaacaacat      960

ggacaaatca gattcagagt taaacagtga agtagcagca aggaaaagaa acttagctct     1020

ggatgaggct gggcagagat ctaccatgta aaatgttgta gagatagagc catataacgt     1080

cacgtttcaa aactagctct acagttttgc ttctcctatt agccatatga taattgggct     1140

atgtagtatc aatatttact ttaatcacaa aggatggttt cttgaaataa tttgtattga     1200

ttgaggccta tgaactgacc tgaattggaa aggatgtgat taatataaat aatagcagat     1260

ataaattgtg gttatgttac ctttatcttg ttgaggacca caacattagc acggtgcctt     1320

gtgcagaata gatactcaat atgtgaatat gtgtctacta gtagttaatt ggataaactg     1380

gcagcatccc tggcctgttg tcatgcagtc atttcctgtt aattctggga gacaatgatt     1440

tcacaactag cgggaagcag tcctaaaagt ttaaaatccg ataaggaata tctgggacag     1500

ggtttagatc atgactctac acagatacca tgatgagagt atattaaaga aatttaggaa     1560

agcacctggt tcctttctcc ccatgcctgc cttctgctcc ctccccagct ggtttgggct     1620

caaattgtcc ctggagacta gggtttatgt tagggtattg atagattaga gcaggtggtt     1680

gaagagatct tctctggtca gacttggaag aatttccaaa actgaagtta gccccaagac     1740

ttccctaggg ttgatgtact ttatgatcca gatgctaaac ttcttagaat gaaaatatgc     1800

ttcaacactt aagtagcata cactgcccta caaacctcag agagcacttt tccccaagtt     1860

cttgttttta tttttgaaag tactcacaca gcacttacta tgctccaaac actcctctaa     1920

gcactttaca catattagct cattcagtcc ccagacagac gggatgaagt aggtattgtt     1980

actgttccca ttttacaggt gagagatttg aagcctgggg aggctagtaa ctcaccccaa     2040

ggtcacacgg ctcatacatg gtgggactga gactcagatg caggcagtct ggcacctcag     2100

tctggattct aaccatttca ctaagctatt tttgtcttgt actactttga cccacccctg     2160

aataaacctc aattgctgga gtggggtgta gttattaaag ggatgctttt taccttttgc     2220

tgtttgctgt ggcagattcc ccagataacc aaggaaaagg ggccacccat acctggaaat     2280

aggccatagg gcccctacta ctgccaacaa gccatggcct accttgacac ttgtttgatc     2340

ttaaaattgt gtcttggtaa caaaagattt ggacaggcat atctgtagct ttcaagttaa     2400

ttaattgcaa tatttttttc ttcaggattt tagctgctga acaactttca gtttggagct     2460

aaaagagacc tgtctcatgg tctgcccttc cctggggcaa tagctagggt ctttcctgat     2520

ttttatggaa ttttagggga tattttgagc tttgggttct cagtagtgaa ttgagacttg     2580

gaggtgactt ttcatgtttg gagtatcatc tctgtctggg atctgggctg acaaattaaa     2640

acctagagta gtgcttatgc tgaaatgata cttttcattt tttggttgat ttttttgcct     2700

tcccttcaat tttaaactga agcattttaa tatgggtaga aactctacac caaatacact     2760

aaacattttg gtgcttagtg gatttctttt taggtaactg gtacttactt ccaaagactg     2820

aatacaagcc acactccatc atatccctta aacttcatga aaaaccattc aagatcccct     2880

tgctgcaaca ctgttctctt cttctctact aaattctatt tccaaaattg gtaatagagc     2940

cagaaggatc cccagtaccc agccctctgc ctggcacaaa gtggtagcac aattaaattc     3000

agtatgggtg gagcatggta cagtcttggt gccatagaag gagtagttgc atagtcacac     3060

atcatttgat aagttggatg ttccattaca tagaggaaca caaaattcca gggtttttgg     3120

aggaagggat tagatagtga ctaagccgcc agaattgagg tggccattcc tttttgtata     3180

ggctaagaaa caggttatca gtgaaaagtt aattatggct ttggcactag aatagcactg     3240

ttgcaaagta tttaagcacc ccccatctca gccctttatt ttatctttca tgtgggctaa     3300

tgtgaggata atcttacaga tattatagga atttcttttc tatctttatg aaaacaacgt     3360

atataaaata tatctagaaa acctttgttt gagactctta tttaatgggc ttttgattct     3420

aatgataatt gtacctttat ctttcaaaag ctgatatttc ctacctaagc atctcccgag     3480

aaaaatatct cattaaaaag cccataaata ataggggaga agaaagcctt aggtatcaat     3540

tccaaaacag tgattgaaat ttcccaaaat aattatggct tctgtcatct ccagagataa     3600

tctggcttgg tttaccccat aatctaattt cagaaaagaa agctttattt taacactcat     3660

ctgaatcaac attaaagcct tttctctcaa agcgtttatt gagaaactca aatgaatata     3720

ctttttgaat tactgtcatc aaaagtgtac ggcttcctgt gctgcttgtg tcaaatggaa     3780

cctgccctct aaagcacttt ctttccttta cttgcgtggt ttcatgtaag ctgtgctgtt     3840

tagaaacaac atctcagact ttacaaagaa atgacaaaga aggcaattgc actttttaag     3900

ggatatcgac aagcagtttc tgttttctaa aggacaaaat acagagtgtg tgtcattttt     3960

aattagattc tttcccctgc tgagttggaa attccagtgc agcactgatt gaccacagtt     4020

gccaatctaa aagcacaaag acagaagtaa agctttatgc taattttatt tcaatatgat     4080

agaaaattta tcttggtatg tcctttttta gataactcca gcaggaaact gtaactgcta     4140

tgtctttagg aaaatgtaga agaaagaaca ttattgttct ttaattccta caaggtactc     4200

gaaaacctta agtgaaaaag atttctatct ttttatctta gcgcatttat ggaaaaaata     4260

ttaactatcc tgaatatttt ataattttgt aggaaaaata tgcatctatt ttttcttgac     4320

ttcttttata tagtaataaa agttattttg gaagctcaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa                                                            4390


<210>  436
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  436

Met Ala Met Glu Gly Tyr Trp Arg Phe Leu Ala Leu Leu Gly Ser Ala 
1               5                   10                  15      


Leu Leu Val Gly Phe Leu Ser Val Ile Phe Ala Leu Val Trp Val Leu 
            20                  25                  30          


His Tyr Arg Glu Gly Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn 
        35                  40                  45              


Trp His Pro Val Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile 
    50                  55                  60                  


Ala Ile Ile Val Tyr Arg Leu Pro Trp Thr Trp Lys Cys Ser Lys Leu 
65                  70                  75                  80  


Leu Met Lys Ser Ile His Ala Gly Leu Asn Ala Val Ala Ala Ile Leu 
                85                  90                  95      


Ala Ile Ile Ser Val Val Ala Val Phe Glu Asn His Asn Val Asn Asn 
            100                 105                 110         


Ile Ala Asn Met Tyr Ser Leu His Ser Trp Val Gly Leu Ile Ala Val 
        115                 120                 125             


Ile Cys Tyr Leu Leu Gln Leu Leu Ser Gly Phe Ser Val Phe Leu Leu 
    130                 135                 140                 


Pro Trp Ala Pro Leu Ser Leu Arg Ala Phe Leu Met Pro Ile His Val 
145                 150                 155                 160 


Tyr Ser Gly Ile Val Ile Phe Gly Thr Val Ile Ala Thr Ala Leu Met 
                165                 170                 175     


Gly Leu Thr Glu Lys Leu Ile Phe Ser Leu Arg Asp Pro Ala Tyr Ser 
            180                 185                 190         


Thr Phe Pro Pro Glu Gly Val Phe Val Asn Thr Leu Gly Leu Leu Ile 
        195                 200                 205             


Leu Val Phe Gly Ala Leu Ile Phe Trp Ile Val Thr Arg Pro Gln Trp 
    210                 215                 220                 


Lys Arg Pro Lys Glu Pro Asn Ser Thr Ile Leu His Pro Asn Gly Gly 
225                 230                 235                 240 


Thr Glu Gln Gly Ala Arg Gly Ser Met Pro Ala Tyr Ser Gly Asn Asn 
                245                 250                 255     


Met Asp Lys Ser Asp Ser Glu Leu Asn Ser Glu Val Ala Ala Arg Lys 
            260                 265                 270         


Arg Asn Leu Ala Leu Asp Glu Ala Gly Gln Arg Ser Thr Met 
        275                 280                 285     


<210>  437
<211>  2974
<212>  DNA
<213>  Homo Sapiens

<400>  437
gcggccgagg gggagcccgc gccgcggctg cagctgccaa gggagcgttc cgagcccacg       60

tcaggggagg tgtcgggata aatagggtcc cgcaatggcc gtggctggct gcgctccgag      120

ctgcggagtc cgggactgga gctgcccggg cgggttcgcg ccccgaaggc tgagagctgg      180

cgctgctcgt gccctgtgtg ccagacggcg gagctccgcg gccggacccc gcggccccgc      240

tttgctgccg actggagttt gggggaagaa actctcctgc gccccagagg atttcttcct      300

cggcgaaggg acagcgaaag atgagggtgg caggaagaga agggcgcttt ctgtctgccg      360

gggtcgcagc gcgagagggc agtgccatgt tcctctccat cctagtggcg ctgtgcctgt      420

ggctgcacct ggcgctgggc gtgcgcggcg cgccctgcga ggcggtgcgc atccctatgt      480

gccggcacat gccctggaac atcacgcgga tgcccaacca cctgcaccac agcacgcagg      540

agaacgccat cctggccatc gagcagtacg aggagctggt ggacgtgaac tgcagcgccg      600

tgctgcgctt cttcctctgt gccatgtacg cgcccatttg caccctggag ttcctgcacg      660

accctatcaa gccgtgcaag tcggtgtgcc aacgcgcgcg cgacgactgc gagcccctca      720

tgaagatgta caaccacagc tggcccgaaa gcctggcctg cgacgagctg cctgtctatg      780

accgtggcgt gtgcatctcg cctgaagcca tcgtcacgga cctcccggag gatgttaagt      840

ggatagacat cacaccagac atgatggtac aggaaaggcc tcttgatgtt gactgtaaac      900

gcctaagccc cgatcggtgc aagtgtaaaa aggtgaagcc aactttggca acgtatctca      960

gcaaaaacta cagctatgtt attcatgcca aaataaaagc tgtgcagagg agtggctgca     1020

atgaggtcac aacggtggtg gatgtaaaag agatcttcaa gtcctcatca cccatccctc     1080

gaactcaagt cccgctcatt acaaattctt cttgccagtg tccacacatc ctgccccatc     1140

aagatgttct catcatgtgt tacgagtggc gctcaaggat gatgcttctt gaaaattgct     1200

tagttgaaaa atggagagat cagcttagta aaagatccat acagtgggaa gagaggctgc     1260

aggaacagcg gagaacagtt caggacaaga agaaaacagc cgggcgcacc agtcgtagta     1320

atccccccaa accaaaggga aagcctcctg ctcccaaacc agccagtccc aagaagaaca     1380

ttaaaactag gagtgcccag aagagaacaa acccgaaaag agtgtgagct aactagtttc     1440

caaagcggag acttccgact tccttacagg atgaggctgg gcattgcctg ggacagccta     1500

tgtaaggcca tgtgcccctt gccctaacaa ctcactgcag tgctcttcat agacacatct     1560

tgcagcattt ttcttaaggc tatgcttcag tttttctttg taagccatca caagccatag     1620

tggtaggttt gccctttggt acagaaggtg agttaaagct ggtggaaaag gcttattgca     1680

ttgcattcag agtaacctgt gtgcatactc tagaagagta gggaaaataa tgcttgttac     1740

aattcgacct aatatgtgca ttgtaaaata aatgccatat ttcaaacaaa acacgtaatt     1800

tttttacagt atgttttatt accttttgat atctgttgtt gcaatgttag tgatgtttta     1860

aaatgtgatc gaaaatataa tgcttctaag aaggaacagt agtggaatga atgtctaaaa     1920

gatctttatg tgtttatggt ctgcagaagg atttttgtga tgaaagggga ttttttgaaa     1980

aatctagaga agtagcatat ggaaaactat aatgtgtctt ttttacaatg acttcagctc     2040

tgtttttagc tagaaactct aaaaacaaaa ataataataa agaaaaataa ataaaaagga     2100

gaggcagaca atgtctggat tcctgttttt tggttacctg atttcatgat catgatgctt     2160

cttgtcaaca ccctcttaag cagcaccaga aacagtgagt ttgtctgtac cattaggagt     2220

taggtactaa ttagttggct aatgctcaag tattttatac ccacaagaga ggtatgtcac     2280

tcatcttact tcccaggaca tccaccctga gaataatttg acaagcttaa aaatggcctt     2340

catgtgagtg ccaaattttg ttttcttcat ttaaatattt tctttgccta aatacatgtg     2400

agaggagtta aatataaatg tacagagagg aaagttgagg ttccacctct gaaatgagaa     2460

ttacttgaca gttgggatac tttaatcaga aaaaaagaac ttatcttgca gcattttatc     2520

aacaaatttc ataattgtgg acaattggag gcatttattt taaaaaacaa ttttattggc     2580

cttttgctaa cacagtaagc atgtattctc tataaggcat tcaataaatg cacaacgccc     2640

aaaggaaata aaatcctatc taatcctact ctccactaca cagaggtaat cactattagt     2700

attttggcat attattctcc aggtgtttct tatgcactta taaaatgatt tgaacaaata     2760

aaactaggaa cctgctatac atgtgtttca taacctgcct cctttgcttg gccctttatt     2820

gagataagtt ttcctgtcaa gaaagcagaa accatctcat ttctaacagc tgtgttatat     2880

tccatagtat gcattactca acaaactgtt gtgctattgg atacttaggt ggtttcttca     2940

ctgacaatac tgaataaaca tctcaatagt caaa                                 2974


<210>  438
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  438

Met Phe Leu Ser Ile Leu Val Ala Leu Cys Leu Trp Leu His Leu Ala 
1               5                   10                  15      


Leu Gly Val Arg Gly Ala Pro Cys Glu Ala Val Arg Ile Pro Met Cys 
            20                  25                  30          


Arg His Met Pro Trp Asn Ile Thr Arg Met Pro Asn His Leu His His 
        35                  40                  45              


Ser Thr Gln Glu Asn Ala Ile Leu Ala Ile Glu Gln Tyr Glu Glu Leu 
    50                  55                  60                  


Val Asp Val Asn Cys Ser Ala Val Leu Arg Phe Phe Leu Cys Ala Met 
65                  70                  75                  80  


Tyr Ala Pro Ile Cys Thr Leu Glu Phe Leu His Asp Pro Ile Lys Pro 
                85                  90                  95      


Cys Lys Ser Val Cys Gln Arg Ala Arg Asp Asp Cys Glu Pro Leu Met 
            100                 105                 110         


Lys Met Tyr Asn His Ser Trp Pro Glu Ser Leu Ala Cys Asp Glu Leu 
        115                 120                 125             


Pro Val Tyr Asp Arg Gly Val Cys Ile Ser Pro Glu Ala Ile Val Thr 
    130                 135                 140                 


Asp Leu Pro Glu Asp Val Lys Trp Ile Asp Ile Thr Pro Asp Met Met 
145                 150                 155                 160 


Val Gln Glu Arg Pro Leu Asp Val Asp Cys Lys Arg Leu Ser Pro Asp 
                165                 170                 175     


Arg Cys Lys Cys Lys Lys Val Lys Pro Thr Leu Ala Thr Tyr Leu Ser 
            180                 185                 190         


Lys Asn Tyr Ser Tyr Val Ile His Ala Lys Ile Lys Ala Val Gln Arg 
        195                 200                 205             


Ser Gly Cys Asn Glu Val Thr Thr Val Val Asp Val Lys Glu Ile Phe 
    210                 215                 220                 


Lys Ser Ser Ser Pro Ile Pro Arg Thr Gln Val Pro Leu Ile Thr Asn 
225                 230                 235                 240 


Ser Ser Cys Gln Cys Pro His Ile Leu Pro His Gln Asp Val Leu Ile 
                245                 250                 255     


Met Cys Tyr Glu Trp Arg Ser Arg Met Met Leu Leu Glu Asn Cys Leu 
            260                 265                 270         


Val Glu Lys Trp Arg Asp Gln Leu Ser Lys Arg Ser Ile Gln Trp Glu 
        275                 280                 285             


Glu Arg Leu Gln Glu Gln Arg Arg Thr Val Gln Asp Lys Lys Lys Thr 
    290                 295                 300                 


Ala Gly Arg Thr Ser Arg Ser Asn Pro Pro Lys Pro Lys Gly Lys Pro 
305                 310                 315                 320 


Pro Ala Pro Lys Pro Ala Ser Pro Lys Lys Asn Ile Lys Thr Arg Ser 
                325                 330                 335     


Ala Gln Lys Arg Thr Asn Pro Lys Arg Val 
            340                 345     


<210>  439
<211>  5496
<212>  DNA
<213>  Homo Sapiens

<400>  439
agtcccattc agggaagcag ccccggcggc cagcagggag ctcaggacag agcaggctcc       60

ctgggaagcc tccgggtgat aggggtgttc cagctgcggc gctctggggg ttcagagggg      120

gatcttgaat gaacaaatga atgaactgct ttctgggcaa acagccacag ccagaggagc      180

ctgtgattgg cagaaagaag ccagggtgtg caagtctccc caacagcctc gagtggcctg      240

cagtcacagg gaaccctcag gaagaccttc cgggcagaga ccagagggaa gcccatctct      300

ccagcagaac tgcttggatt tttctaccag gaggctcagg gctctgcaac aatgatagca      360

gaagctgatg gcatctagag atctaggctg ggactagcac agcatcactt ctaccacttt      420

ctgttggtca cagcaactca ccatgccagt gcagattcaa ggggaggaga aatagagtcc      480

acttcttgat gggaggcgtg acatgtgttt ctagctgtgt acagggactg attggctgag      540

gactcacatt ggagagctgc agacaacata acggtgaatg agaatggagg atgaagatta      600

caacacttcc atcagttacg gtgatgaata ccctgattat ttagactcca ttgtggtttt      660

ggaggactta tcccccttgg aagccagggt gaccaggatc ttcctggtgg tggtctacag      720

catcgtctgc ttcctcggga ttctgggcaa tggtctggtg atcatcattg ccaccttcaa      780

gatgaagaag acagtgaaca tggtctggtt cctcaacctg gcagtggcag atttcctgtt      840

caacgtcttc ctcccaatcc atatcaccta tgccgccatg gactaccact gggttttcgg      900

gacagccatg tgcaagatca gcaacttcct tctcatccac aacatgttca ccagcgtctt      960

cctgctgacc atcatcagct ctgaccgctg catctctgtg ctcctccctg tctggtccca     1020

gaaccaccgc agcgttcgcc tggcttacat ggcctgcatg gtcatctggg tcctggcttt     1080

cttcttgagt tccccatctc tcgtcttccg ggacacagcc aacctgcatg ggaaaatatc     1140

ctgcttcaac aacttcagcc tgtccacacc tgggtcttcc tcgtggccca ctcactccca     1200

aatggaccct gtggggtata gccggcacat ggtggtgact gtcacccgct tcctctgtgg     1260

cttcctggtc ccagtcctca tcatcacagc ttgctacctc accatcgtgt gcaaactgca     1320

gcgcaaccgc ctggccaaga ccaagaagcc cttcaagatt attgtgacca tcatcattac     1380

cttcttcctc tgctggtgcc cctaccacac actcaacctc ctagagctcc accacactgc     1440

catgcctggc tctgtcttca gcctgggttt gcccctggcc actgcccttg ccattgccaa     1500

cagctgcatg aaccccattc tgtatgtttt catgggtcag gacttcaaga agttcaaggt     1560

ggccctcttc tctcgcctgg tcaatgctct aagtgaagat acaggccact cttcctaccc     1620

cagccataga agctttacca agatgtcatc aatgaatgag aggacttcta tgaatgagag     1680

ggagaccggc atgctttgat cctcactgtg gaacccctca atggactctc tcaacccagg     1740

gacacccaag gatatgtctt ctgaagatca aggcaagaac ctctttagca tccaccaatt     1800

ttcactgcat tttgcatggg atgaacagtg ttttatgctg ggaatctagg gcctggaacc     1860

cctttcttct agtggacaga acatgctgtg ttccatacag ccttggacta gcaatttatg     1920

cttcttggga ggccagcctt gactgactca aagcaaaaaa ggaagaattc tcaaaagcat     1980

tgccatgaac tgggattggc atagggcggt gggattaagc tgcctattgt gtgtgcccca     2040

gaaatgacac tctccaaggt ccattcctgg tgtgagcagt gagggggtca gagcaaaccc     2100

agtgtgatgc agatcacact tggcccttgt atatatatta tcagtagctg gccagaaaac     2160

cctaccttca agtcactgct ctgtgttaaa gtatgtggaa atgcataggt gatctgggag     2220

aggaaggtga catatcagcc catgaactcc ataggccatg aatttggctt tcggatcagc     2280

taggaagaca gagaactggt cctgagaggt cctgtgggct ctttgcaagg gcaagacaag     2340

tgagggatgc aacgaggact tgagatttgg caaagaaatg agaaaggaga aaagaacctt     2400

taaaggatgc aggcatggag cagctcaccc tagaacatcg caggctgatg gtgctttagg     2460

ctggagctat ttggggcgtc agggtggtgc cagcccctga tctcaccttg cccctcttac     2520

ctgggggtgg ggttgtggca ggcatcttca ccagcagccc tcaccccatc acagggattt     2580

ttttctgcct ttcctaatcc actcagctct ggctggaggt gcttagaata aaacactggt     2640

ggtggggctt ctcattctgg ttaatttcct caacgccttt ggagacaggt ccaaaatgca     2700

gctttgggaa gcaactccgg agagtcccct gggaagaaga gtatgtccga ggactcagtc     2760

acttgagaca gagtctggag ctggactcct tgaactgtgt ttctgagctg cagacaccaa     2820

atacctcctg gatacaggtg cctggcatgg cttttctcat ctaatactga cacgtccctg     2880

tggccacaga gtgtcatagc cccatttaca aatgacatag ctgaggccca gatggggaaa     2940

gtaacttgcc cagcatcaca cagctaatca gtggcagagt taagatctga acctggctcc     3000

gtctggctcc agaaactctg ttcttctatt tggaatttat ctgtggagat tattctagta     3060

tattgatagc ctacatttat ttagcacttt ttatattatg cactttacat atgttttctc     3120

atttaatcat tacagcaacc ctgagttagg tatggttata acttcccttt tacataggag     3180

gaatctgagg cttagagagg ttaagtaact tgcccaaagg tacccagcta gtctctgccg     3240

gagcttggat ttgaacttca gtttgcctgg ctcaaatgag gctgcagagt tgggaaggac     3300

ttaaaaagtt tggagatttt tgccataaat attgattttt ctgcaaatga ggatgaacat     3360

cttaatggcc tttaagaaac tttgcaaata gttttcaaaa atgatgcaac atggcagaga     3420

aaatgcactt ggcttccagc tccctcaaca gccattaaca gcctcctacc gtggctccca     3480

cctcctatgt ctccagagat caaggcaatg gggagggaaa gctggcagga ggcagtccct     3540

tgtgggcctg aggccctttg gctcctaagt gtccacattc tgttctcttc caagtccctt     3600

cattgttaag ctgattctcc aacaagatgc aatgaacaga tgcaatgtct accccgcgct     3660

gggcgagttc ccgaggccat gggctgtttg gaatcacact tcattaagag acaaactgtt     3720

ccttccctta ttgtgcctta atgcttatga caaggcagct ctgaattgat cccaagctgg     3780

agcctctgaa tgctttaaag agtttgaata tagacggttt gagagcaaaa agggagcttt     3840

aaatattgct cagtggcccc catctcccct cttcccacat ttactgaggc acgagatggg     3900

atgggacctg tcccgggtca cagcagcagt cgtcagcgcc ttggccctcc tggcttgtag     3960

gatgctgctt ttcctgggct tctggcagtc caggccagga tgggggagcc aggaattcat     4020

gttgtcattg gaaaagctga taaacaggag cacaattcaa accggctgtt ttcctcctta     4080

gagtctggcc tccctctttc tggctgctct gtgggtcttc ctgttctgac ttaggttcct     4140

gtcaagtact taaatgcagc cttaacatcc catacagtct tgtccccaca gcttcatgtg     4200

aacatctcca tgggtcatgc atatatcgtc cctgcagtgt gcaaagtgtg ctcacctgca     4260

ctgctgcaca ggcaaccaac atacttagtg cccagagcct tctctctggg cccaggactc     4320

agtgatgggg ccttacttag ccctgcctcc tgggtggggt gggggagctg agggatcgtg     4380

aggacaagag gtagagggaa aagaaaagaa gatggtgttt gaggataggg gagggacagg     4440

agaggggaca gaaaggtccc agagcatgat gatgaaggaa agggatctgg cattcatgaa     4500

gcacctacga tggttcaggc acaaacactg aaacctcaaa ttggccctgg cagaagggga     4560

ccatcatagc aaggtggggg gggggtgcag aaagtgagtt tctgtttcaa gaacagactt     4620

cactagttca gagttgcaca gctagtgagg tatggagctg ggctttgaat caggtcagct     4680

gcctgaatgc ccaacttctt cagcccttgg aaggagaggg tggggagaag aagaaggaaa     4740

agacaaggaa gaaagaaaga agagagaagg ggagaggaat ggaagtccaa agagtgggag     4800

gaatttgatt tcagaaccat ctccagctga cccttgagcc agcaaggaca gggagaaggg     4860

aagagcaaga acacgaaggg cctcaagcac cgggatgcct ttgccagcct tagataattc     4920

ccagagcgca cagagccctg caggttcctg ggtccttctc cagagaagag gcacagagat     4980

tctggcagca aggttcagaa ggggtgagga aactgggcac tgacaaaggg aggggattgg     5040

ctcaaattcg accccagagt cagctctggt ggggttggga gcctggatgg gtgggagaag     5100

atagaatcca atcgtgaaaa ccataaggga ccttcaaact catcttgccc agatgtctcc     5160

catttcacag atgagggaac tgaggttttg agagcttccc ctgaggactc tgcaaaacga     5220

ggtggtgtct ggtttggatg aaagtggtcg gtgattcctc aactcctgcc ctgcctccct     5280

ctctcgttcc tccctaacat gttatgctct tgttggggct gggatgccct aggcccaagg     5340

ttaccaaatc ctgggtttgg aaaattgctg ctgggggtgg tatctaggac cagagaggaa     5400

tctactattt ctactgtgaa ataattcagc agggggtctt cttacttctt ccctttgagg     5460

acaaagtttc tctcgaataa agagactgaa gcaaga                               5496


<210>  440
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  440

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  441
<211>  2820
<212>  DNA
<213>  Homo Sapiens

<400>  441
gggagttcag acctagatct ttccagttaa tcacacaaca aacttagctc atcgcaataa       60

aaagcagctc agagccgact ggctctttta ggcactgact ccgaacagga ttctttcacc      120

caggcatctc ctccagaggg atccgccagc ccgtccagca gcaccatgtg ggtgaccaaa      180

ctcctgccag ccctgctgct gcagcatgtc ctcctgcatc tcctcctgct ccccatcgcc      240

atcccctatg cagagggaca aaggaaaaga agaaatacaa ttcatgaatt caaaaaatca      300

gcaaagacta ccctaatcaa aatagatcca gcactgaaga taaaaaccaa aaaagtgaat      360

actgcagacc aatgtgctaa tagatgtact aggaataaag gacttccatt cacttgcaag      420

gcttttgttt ttgataaagc aagaaaacaa tgcctctggt tccccttcaa tagcatgtca      480

agtggagtga aaaaagaatt tggccatgaa tttgacctct atgaaaacaa agactacatt      540

agaaactgca tcattggtaa aggacgcagc tacaagggaa cagtatctat cactaagagt      600

ggcatcaaat gtcagccctg gagttccatg ataccacacg aacacagctt tttgccttcg      660

agctatcggg gtaaagacct acaggaaaac tactgtcgaa atcctcgagg ggaagaaggg      720

ggaccctggt gtttcacaag caatccagag gtacgctacg aagtctgtga cattcctcag      780

tgttcagaag ttgaatgcat gacctgcaat ggggagagtt atcgaggtct catggatcat      840

acagaatcag gcaagatttg tcagcgctgg gatcatcaga caccacaccg gcacaaattc      900

ttgcctgaaa gatatcccga caagggcttt gatgataatt attgccgcaa tcccgatggc      960

cagccgaggc catggtgcta tactcttgac cctcacaccc gctgggagta ctgtgcaatt     1020

aaaacatgcg ctgacaatac tatgaatgac actgatgttc ctttggaaac aactgaatgc     1080

atccaaggtc aaggagaagg ctacaggggc actgtcaata ccatttggaa tggaattcca     1140

tgtcagcgtt gggattctca gtatcctcac gagcatgaca tgactcctga aaatttcaag     1200

tgcaaggacc tacgagaaaa ttactgccga aatccagatg ggtctgaatc accctggtgt     1260

tttaccactg atccaaacat ccgagttggc tactgctccc aaattccaaa ctgtgatatg     1320

tcacatggac aagattgtta tcgtgggaat ggcaaaaatt atatgggcaa cttatcccaa     1380

acaagatctg gactaacatg ttcaatgtgg gacaagaaca tggaagactt acatcgtcat     1440

atcttctggg aaccagatgc aagtaagctg aatgagaatt actgccgaaa tccagatgat     1500

gatgctcatg gaccctggtg ctacacggga aatccactca ttccttggga ttattgccct     1560

atttctcgtt gtgaaggtga taccacacct acaatagtca atttagacca tcccgtaata     1620

tcttgtgcca aaacgaaaca attgcgagtt gtaaatggga ttccaacacg aacaaacata     1680

ggatggatgg ttagtttgag atacagaaat aaacatatct gcggaggatc attgataaag     1740

gagagttggg ttcttactgc acgacagtgt ttcccttctc gagacttgaa agattatgaa     1800

gcttggcttg gaattcatga tgtccacgga agaggagatg agaaatgcaa acaggttctc     1860

aatgtttccc agctggtata tggccctgaa ggatcagatc tggttttaat gaagcttgcc     1920

aggcctgctg tcctggatga ttttgttagt acgattgatt tacctaatta tggatgcaca     1980

attcctgaaa agaccagttg cagtgtttat ggctggggct acactggatt gatcaactat     2040

gatggcctat tacgagtggc acatctctat ataatgggaa atgagaaatg cagccagcat     2100

catcgaggga aggtgactct gaatgagtct gaaatatgtg ctggggctga aaagattgga     2160

tcaggaccat gtgaggggga ttatggtggc ccacttgttt gtgagcaaca taaaatgaga     2220

atggttcttg gtgtcattgt tcctggtcgt ggatgtgcca ttccaaatcg tcctggtatt     2280

tttgtccgag tagcatatta tgcaaaatgg atacacaaaa ttattttaac atataaggta     2340

ccacagtcat agctgaagta agtgtgtctg aagcacccac caatacaact gtcttttaca     2400

tgaagatttc agagaatgtg gaatttaaaa tgtcacttac aacaatccta agacaactac     2460

tggagagtca tgtttgttga aattctcatt aatgtttatg ggtgttttct gttgttttgt     2520

ttgtcagtgt tattttgtca atgttgaagt gaattaaggt acatgcaagt gtaataacat     2580

atctcctgaa gatacttgaa tggattaaaa aaacacacag gtatatttgc tggatgataa     2640

agatttcatg ggaaaaaaaa tcaattaatc tgtctaagct gctttctgat gttggtttct     2700

taataatgag taaaccacaa attaaatgtt attttaacct caccaaaaca atttatacct     2760

tgtgtcccta aattgtagcc ctatattaaa ttatattaca tttcaaaaaa aaaaaaaaaa     2820


<210>  442
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  442

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  443
<211>  760
<212>  DNA
<213>  Homo Sapiens

<400>  443
gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac       60

tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac      120

cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta      180

taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag      240

cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc      300

tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac      360

tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct      420

agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa      480

cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt      540

catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca      600

cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt      660

ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt      720

acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa                            760


<210>  444
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  444

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  445
<211>  10607
<212>  DNA
<213>  Homo Sapiens

<400>  445
attctgcgag gaatggcagc ggcagcagca tccccgccag aggcggcggc ggcggcggca       60

gcggccacgg ccaccaccgc ggacgctatt gttccctggt gttagacgcg ctctccctcc      120

ttctcatctg aagcgaacaa tagcaggaaa gagctttgct ttctgtactc tttgaaaaga      180

cgttccaaga gcggagaaaa attccctgcc gagcgtgcta cggctctgga ccctggagtg      240

gctgcaggcg gcatggggct gcaagccagg cgctgggcgt ccgggagccg gggcgctgcg      300

gggccgcgcc ggggcgtcct gcagctgctg ccgctgccgc tgccgctgcc gctgctcctg      360

ctgctgctgc tacgcccggg cgccggcagg gctgcggcgc agggcgaggc ggaggcgccc      420

accctctatc tgtggaagac tggtccatgg ggccgatgta tgggagatga atgtggtccc      480

ggaggcatcc aaacgagggc tgtgtggtgt gctcatgtgg agggatggac tacactgcat      540

actaactgta agcaggccga gagacccaat aaccagcaga attgtttcaa agtttgcgat      600

tggcacaaag agttgtacga ctggagactg ggaccttgga atcagtgtca gcccgtgatt      660

tcaaaaagcc tagagaaacc tcttgagtgc attaaggggg aagaaggtat tcaggtgagg      720

gagatagcgt gcatccagaa agacaaagac attcctgcgg aggatatcat ctgtgagtac      780

tttgagccca agcctctcct ggagcaggct tgcctcattc cttgccagca agattgcatc      840

gtgtctgaat tttctgcctg gtccgaatgc tccaagacct gcggcagcgg gctccagcac      900

cggacgcgtc atgtggtggc gcccccgcag ttcggaggct ctggctgtcc aaacctgacg      960

gagttccagg tgtgccaatc cagtccatgc gaggccgagg agctcaggta cagcctgcat     1020

gtggggccct ggagcacctg ctcaatgccc cactcccgac aagtaagaca agcaaggaga     1080

cgcgggaaga ataaagaacg ggaaaaggac cgcagcaaag gagtaaagga tccagaagcc     1140

cgcgagctta ttaagaaaaa gagaaacaga aacaggcaga acagacaaga gaacaaatat     1200

tgggacatcc agattggata tcagaccaga gaggttatgt gcattaacaa gacggggaaa     1260

gctgctgatt taagcttttg ccagcaagag aagcttccaa tgaccttcca gtcctgtgtg     1320

atcaccaaag agtgccaggt ttccgagtgg tcagagtgga gcccctgctc aaaaacatgc     1380

catgacatgg tgtcccctgc aggcactcgt gtaaggacac gaaccatcag gcagtttccc     1440

attggcagtg aaaaggagtg tccagaattt gaagaaaaag aaccctgttt gtctcaagga     1500

gatggagttg tcccctgtgc cacgtatggc tggagaacta cagagtggac tgagtgccgt     1560

gtggaccctt tgctcagtca gcaggacaag aggcgcggca accagacggc cctctgtgga     1620

gggggcatcc agacccgaga ggtgtactgc gtgcaggcca acgaaaacct cctctcacaa     1680

ttaagtaccc acaagaacaa agaagcctca aagccaatgg acttaaaatt atgcactgga     1740

cctatcccta atactacaca gctgtgccac attccttgtc caactgaatg tgaagtttca     1800

ccttggtcag cttggggacc ttgtacttat gaaaactgta atgatcagca agggaaaaaa     1860

ggcttcaaac tgaggaagcg gcgcattacc aatgagccca ctggaggctc tggggtaacc     1920

ggaaactgcc ctcacttact ggaagccatt ccctgtgaag agcctgcctg ttatgactgg     1980

aaagcagtga gactgggaaa ctgcgagcca gataacggaa aggagtgtgg tccaggcacg     2040

caagttcaag aggttgtgtg catcaacagt gatggagaag aagttgacag acagctgtgc     2100

agagatgcca tcttccccat ccctgtggcc tgtgatgccc catgcccgaa agactgtgtg     2160

ctcagcacat ggtctacgtg gtcctcctgc tcacacacct gctcagggaa aacgacagaa     2220

gggaaacaga tacgagcacg atccattctg gcctatgcgg gtgaagaagg tggaattcgc     2280

tgtccaaata gcagtgcttt gcaagaagta cgaagctgta atgagcatcc ttgcacagtg     2340

taccactggc aaactggtcc ctggggccag tgcattgagg acacctcagt atcgtccttc     2400

aacacaacta cgacttggaa tggggaggcc tcctgctctg tcggcatgca gacaagaaaa     2460

gtcatctgtg tgcgagtcaa tgtgggccaa gtgggaccca aaaaatgtcc tgaaagcctt     2520

cgacctgaaa ctgtaaggcc ttgtctgctt ccttgtaaga aggactgtat tgtgacccca     2580

tatagtgact ggacatcatg cccctcttcg tgtaaagaag gggactccag tatcaggaag     2640

cagtctaggc atcgggtcat cattcagctg ccagccaacg ggggccgaga ctgcacagat     2700

cccctctatg aagagaaggc ctgtgaggca cctcaagcgt gccaaagcta caggtggaag     2760

actcacaaat ggcgcagatg ccaattagtc ccttggagcg tgcaacaaga cagccctgga     2820

gcacaggaag gctgtgggcc tgggcgacag gcaagagcca ttacttgtcg caagcaagat     2880

ggaggacagg ctggaatcca tgagtgccta cagtatgcag gccctgtgcc agcccttacc     2940

caggcctgcc agatcccctg ccaggatgac tgtcaattga ccagctggtc caagttttct     3000

tcatgcaatg gagactgtgg tgcagttagg accagaaagc gcactcttgt tggaaaaagt     3060

aaaaagaagg aaaaatgtaa aaattcccat ttgtatcccc tgattgagac tcagtattgt     3120

ccttgtgaca aatataatgc acaacctgtg gggaactggt cagactgtat tttaccagag     3180

ggaaaagtgg aagtgttgct gggaatgaaa gtacaaggag acatcaagga atgcggacaa     3240

ggatatcgtt accaagcaat ggcatgctac gatcaaaatg gcaggcttgt ggaaacatct     3300

agatgtaaca gccatggtta cattgaggag gcctgcatca tcccctgccc ctcagactgc     3360

aagctcagtg agtggtccaa ctggtcgcgc tgcagcaagt cctgtgggag tggtgtgaag     3420

gttcgttcta aatggctgcg tgaaaaacca tataatggag gaaggccttg ccccaaactg     3480

gaccatgtca accaggcaca ggtgtatgag gttgtcccat gccacagtga ctgcaaccag     3540

tacctatggg tcacagagcc ctggagcatc tgcaaggtga cctttgtgaa tatgcgggag     3600

aactgtggag agggcgtgca aacccgaaaa gtgagatgca tgcagaatac agcagatggc     3660

ccttctgaac atgtagagga ttacctctgt gacccagaag agatgcccct gggctctaga     3720

gtgtgcaaat taccatgccc tgaggactgt gtgatatctg aatggggtcc atggacccaa     3780

tgtgttttgc cttgcaatca aagcagtttc cggcaaaggt cagctgatcc catcagacaa     3840

ccagctgatg aaggaagatc ttgccctaat gctgttgaga aagaaccctg taacctgaac     3900

aaaaactgct accactatga ttataatgta acagactgga gtacatgtca gctgagtgag     3960

aaggcagttt gtggaaatgg aataaaaaca aggatgttgg attgtgttcg aagtgatggc     4020

aagtcagttg acctgaaata ttgtgaagcg cttggcttgg agaagaactg gcagatgaac     4080

acgtcctgca tggtggaatg ccctgtgaac tgtcagcttt ctgattggtc tccttggtca     4140

gaatgttctc aaacatgtgg cctcacagga aaaatgatcc gaagacgaac agtgacccag     4200

ccctttcaag gtgatggaag accatgccct tccctgatgg accagtccaa accctgccca     4260

gtgaagcctt gttatcggtg gcaatatggc cagtggtctc catgccaagt gcaggaggcc     4320

cagtgtggag aagggaccag aacaaggaac atttcttgtg tagtaagtga tgggtcagct     4380

gatgatttca gcaaagtggt ggatgaggaa ttctgtgctg acattgaact cattatagat     4440

ggtaataaaa atatggttct ggaggaatcc tgcagccagc cttgcccagg tgactgttat     4500

ttgaaggact ggtcttcctg gagcctgtgt cagctgacct gtgtgaatgg tgaggatcta     4560

ggctttggtg gaatacaggt cagatccaga ccggtgatta tacaagaact agagaatcag     4620

catctgtgcc cagagcagat gttagaaaca aaatcatgtt atgatggaca gtgctatgaa     4680

tataaatgga tggccagtgc ttggaagggc tcttcccgaa cagtgtggtg tcaaaggtca     4740

gatggtataa atgtaacagg gggctgcttg gtgatgagcc agcctgatgc cgacaggtct     4800

tgtaacccac cgtgtagtca accccactcg tactgtagcg agacaaaaac atgccattgt     4860

gaagaagggt acactgaagt catgtcttct aacagcaccc ttgagcaatg cacacttatc     4920

cccgtggtgg tattacccac catggaggac aaaagaggag atgtgaaaac cagtcgggct     4980

gtacatccaa cccaaccctc cagtaaccca gcaggacggg gaaggacctg gtttctacag     5040

ccatttgggc cagatgggag actaaagacc tgggtttacg gtgtagcagc tggggcattt     5100

gtgttactca tctttattgt ctccatgatt tatctagctt gcaaaaagcc aaagaaaccc     5160

caaagaaggc aaaacaaccg actgaaacct ttaaccttag cctatgatgg agatgccgac     5220

atgtaacata taacttttcc tggcaacaac cagtttcggc tttctgactt catagatgtc     5280

cagaggccac aacaaatgta tccaaactgt gtggattaaa atatatttta atttttaaaa     5340

atggcatcat aaagacaaga gtgaaaatca tactgccact ggagatattt aagacagtac     5400

cacttatata cagaccatca accgtgagaa ttataggaga tttagctgaa tacatgctgc     5460

attctgaaag ttttatgtca tcttttctga aatctaccga ctgaaaaacc actttcatct     5520

ctaaaaaata atggtggaat tggccagtta ggatgcctga tacaagaccg tctgcagtgt     5580

taatccataa aacttcctag catgaagagt ttctaccaag atctccacaa tactatggtc     5640

aaattaacat gtgtactcag ttgaatgaca cacattatgt cagattatgt acttgctaat     5700

aagcaatttt aacaatgcat aacaaataaa ctctaagcta agcagaaaat ccactgaata     5760

aattcagcat cttggtggtc gatggtagat tttattgacc tgcatttcag agacaaagcc     5820

tcttttttaa gacttcttgt ctctctccaa agtaagaatg ctggacaagt actagtgtct     5880

tagaagaacg agtcctcaag ttcagtattt tatagtggta attgtctgga aaactaattt     5940

acttgtgtta atacaatacg tttctacttt ccctgatttt caaactggtt gcctgcatct     6000

tttttgctat atggaaggca catttttgca ctatattagt gcagcacgat aggcgcttaa     6060

ccagtattgc catagaaact gcctcttttc atgtgggatg aagacatctg tgccaagagt     6120

ggcatgaaga catttgcaag ttcttgtatc ctgaagagag taaagttcag tttggatggc     6180

agcaagatga aatcagctat tacacctgct gtacacacac ttcctcatca ctgcagccat     6240

tgtgaaattg acaacatggc ggtaatttaa gtgttgaagt ccctaacccc ttaaccctct     6300

aaaaggtgga ttcctctagt tggtttgtaa ttgttctttg aaggctgttt atgactagat     6360

ttttatattt gttatctttg ttaagaaaaa aaaagaaaaa ggaactggat gtctttttaa     6420

ttttgagcag atggagaaaa taaataatgt atcaatgacc tttgtaacta aaggaaatca     6480

aaattatatg ttgatttttc tttctctctg atttcccagt ttcagattga atgtctgtct     6540

tgcaggcagt tatttcaaaa tccatagtct tttgcctttc tcactggcaa aatttgaagc     6600

aatctctctc ttcaatgtat gatttcaaaa ctaaaatttt aaaagagaag aataaatatc     6660

ttatccaaga cttcattgca tatctagagc aagagtggca aactttttct gtaaaggact     6720

atatagaaaa tattttccac aaggtctatg ttgcaacttc tcaactttgc cattctgcta     6780

atgcaatctt agtaaataaa agaatgaaca taactgtttt cctatataac ttcccttaca     6840

aaaacagcca gtaggccacc tttgcaggtc atattttgct gacccctggt ctggatgttt     6900

tttaatgcta gctctccatg gtgtcatctt tcgttttcat tcatttttca aaggtgagaa     6960

tttacagtca ttacatttcc cactgtatca gaagtagctg tattttctac agatgtagcc     7020

ctgggaatgg cacagtggaa caatatttaa ctaactcagc agacttcttg caaatgaaaa     7080

gaaaactcaa aaggtgccat taaaaagcaa taccattttc aggcaacatt attgcaacaa     7140

cctttgtgag agaggacact agcttttcag gatatttgaa aaataatata actaacatgc     7200

tattttatct taaacagctg tgttcctgta aaagtgtttt ggattagaag gtatttttac     7260

cttcatactg gagtatgaac tccccctgct gttcattaga gtatttgcaa agattacaaa     7320

agacatcagg ttaggatgtc attgtcccca aaatgaaaat atttgtatgt atttcaataa     7380

gaactaaatg cagtaagcgc taattcctca ttcaatattc actatattag gaaatgtaaa     7440

tcatttcaaa gagaacaggt agtcaggaag atgaaaattt tactttaaag caaggattta     7500

aacaaagaaa accataaaaa caaagtccat tttatctgtt ttattaaaga ggaagaaaaa     7560

ataatattgt tactttaaaa ctgtgattgt caatatatat aatcaggggt cttccagata     7620

atcctaaagt tgatctcttt gaataaaata aactccattt gtccaaaata gttaagaaag     7680

actctattgt ggttacttga aaaattcagc taaccctctt atgaaatgtg tgcaacacct     7740

attaattttg aaatgtggga tagaatacct actaaagcta tatttaaggt attgtaaaat     7800

gtcattaatt cagaaaagat tagtatcatc ctacctataa gaattaaatt agcaaatcaa     7860

aattatagaa tgttatgaaa aatacatttt attcataaat taattagatt ttacagcata     7920

tatgcatgca tatatatata tacacacaca cacacacaca cccatatata tgagagagag     7980

gaaattaggt tcaacatgac ctaatattag agaacatatt ggaaggtcac tgtttgttag     8040

gataaataaa tactggataa cctcgttaga aaggtggaaa gaggagaacg tagcaatctg     8100

gctattttgg acaaagggaa ggttattata ttcatgttta taacatgaaa atggccttat     8160

ttttgtttct gacatgagac aataatgagt taaatatttt attggaattt catcaaaacc     8220

ttatttttac tgttccttct aaaaatttgg gaggggaata tagtagtaac ttctctattg     8280

acacttttac ctcaccgagg gggtaaaaga tgtagaactg ctgttcccta gaatgaaggt     8340

ctgttgtttg gtttttaaaa aaagaagagc agaaaaagtt tgacacagta ttatatgatt     8400

ttgctggact atttcactag aaaccacgta gaataggact aactgatctc ttttgaaagg     8460

ggctgatttg cttattcatc aataactaat ccaatatgtg gacagtaatc ttaatttcaa     8520

agcctttttt gaggatacta cggtgtagct taagtgaatt taaaaagagt gcataaaagc     8580

ttgtttttaa ttacttataa caaagcacaa attacttcta acaaggcaaa tatttattga     8640

catataagac attctgctag gcattgtaaa aaaaaaaaaa aaagtaatgg cttttgtata     8700

cataggtact taagacagac atccaaaaga aggaaaaaat gcttaatgag tgaagatagc     8760

actgaaacat gttgactttt actctaggtt tgtttttaga tggggttagt attttcccct     8820

acgtaatgta catgtcttta ggccacagta ttaggagttt gatttttccc tgccccaccc     8880

tcaggtaggt ggcagtggtc attgtagctt aatcagaccc ctgttaagtt cctgggcatt     8940

tcaaggtaaa ttcacgtctt ccttctcaca gaaattgaat agacctctca cacacttatt     9000

tacctccccc aacaacctgt atccttggcc ctttctgatt ttctctgctt ggtctctttc     9060

tactcttgac agctattctt acctacttcc cactaaacat gcccaatttt ttaattaaaa     9120

aaaaaagaat tcctatattt ccttccctat tagaatcaaa gtgtcactca ctcagagtgt     9180

gaacatcctg atttacacca aatccactgg tcaaagaaat gaataaaggg aaaaggaaaa     9240

atgtggaagg catgcaggaa aaaaaaaaaa aaaaaagccc ttttctgtaa aaatgtccat     9300

gcctacactt gctttagacc atcccatatc ctcctgcctc catctcgagt ctttgttcac     9360

attccacacc acaagacagt gagggaggac tgtacttttc agtaccatac agaagggaga     9420

gcctgttcta aagctgacgt gggtctcaat agtacatgag aagcacaatt cccaaatgat     9480

ctgggatctc ctgtttataa atatattacc aaattcaagt gtgggttctt cttctatttc     9540

cactgtaaga ttgagggtgt tgaaaaaaca gtagtccttg agcaaatctg tgaggaatct     9600

tgtcagaatg tgatctttcc tgggactagt ttagttgtga gaactacatc tgcttgttct     9660

gggaataagg gtctccccag gtcctgccct caggtggccc tggctgcagg acaggatttc     9720

aggtatcaga aactggtgtg tgagccaagc aaatagttat ccatttataa aaaggatggt     9780

ttgcagtgtg ttataataat tttatatcta gcagggacaa tgaaaaatgg ttatgtctac     9840

attattaaat gaatgaaact aatgctaaac agttaatttt gcatttttat ttttctgtgt     9900

ttctaccaag tcagatctta aaaatgggca gtatatgaag agctttagtt tgtgggagtc     9960

atgttttcag tgatcaaaaa tctctatatt atttagaata taattgtcag tcttgttgtg    10020

ttttgtagat ttattgtttt taagccatag tttctagatt acctactttt aaccctcaag    10080

taaacttttc cctatttttc agaaatctgt ttgtgtttat ttttagaaag taaacattta    10140

gattcctttt ctggtacttt ttttctccat ttctatcaca cagatttgaa gagatcagta    10200

tctatcattg taaaatataa ctttattaaa atttgcaatc tgtctttcta taaattatta    10260

ttccctaaat gtgtatttta tgttaattta actacctgaa tatttatttt gtttaaataa    10320

ggaggcagct gtctaagaat ttttgttaat attactttgt aaattgcgta atgtaattta    10380

ttttacatta tgtacatttc ctttttaacg cacaaaatgt ctatgtacaa ttaactacag    10440

atttgcaaat aatgtcacta agctttattc agtcaataca gatggcatgt gaagatgtaa    10500

tatgcttttt tacattttca tatgggttat ttgtaaataa ctatattgct gacaaacata    10560

aatacggaaa tcattttcat tctaaaaaaa aaaaaaaaaa aaaaaaa                  10607


<210>  446
<211>  1657
<212>  PRT
<213>  Homo Sapiens

<400>  446

Met Gly Leu Gln Ala Arg Arg Trp Ala Ser Gly Ser Arg Gly Ala Ala 
1               5                   10                  15      


Gly Pro Arg Arg Gly Val Leu Gln Leu Leu Pro Leu Pro Leu Pro Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Leu Leu Leu Arg Pro Gly Ala Gly Arg Ala Ala 
        35                  40                  45              


Ala Gln Gly Glu Ala Glu Ala Pro Thr Leu Tyr Leu Trp Lys Thr Gly 
    50                  55                  60                  


Pro Trp Gly Arg Cys Met Gly Asp Glu Cys Gly Pro Gly Gly Ile Gln 
65                  70                  75                  80  


Thr Arg Ala Val Trp Cys Ala His Val Glu Gly Trp Thr Thr Leu His 
                85                  90                  95      


Thr Asn Cys Lys Gln Ala Glu Arg Pro Asn Asn Gln Gln Asn Cys Phe 
            100                 105                 110         


Lys Val Cys Asp Trp His Lys Glu Leu Tyr Asp Trp Arg Leu Gly Pro 
        115                 120                 125             


Trp Asn Gln Cys Gln Pro Val Ile Ser Lys Ser Leu Glu Lys Pro Leu 
    130                 135                 140                 


Glu Cys Ile Lys Gly Glu Glu Gly Ile Gln Val Arg Glu Ile Ala Cys 
145                 150                 155                 160 


Ile Gln Lys Asp Lys Asp Ile Pro Ala Glu Asp Ile Ile Cys Glu Tyr 
                165                 170                 175     


Phe Glu Pro Lys Pro Leu Leu Glu Gln Ala Cys Leu Ile Pro Cys Gln 
            180                 185                 190         


Gln Asp Cys Ile Val Ser Glu Phe Ser Ala Trp Ser Glu Cys Ser Lys 
        195                 200                 205             


Thr Cys Gly Ser Gly Leu Gln His Arg Thr Arg His Val Val Ala Pro 
    210                 215                 220                 


Pro Gln Phe Gly Gly Ser Gly Cys Pro Asn Leu Thr Glu Phe Gln Val 
225                 230                 235                 240 


Cys Gln Ser Ser Pro Cys Glu Ala Glu Glu Leu Arg Tyr Ser Leu His 
                245                 250                 255     


Val Gly Pro Trp Ser Thr Cys Ser Met Pro His Ser Arg Gln Val Arg 
            260                 265                 270         


Gln Ala Arg Arg Arg Gly Lys Asn Lys Glu Arg Glu Lys Asp Arg Ser 
        275                 280                 285             


Lys Gly Val Lys Asp Pro Glu Ala Arg Glu Leu Ile Lys Lys Lys Arg 
    290                 295                 300                 


Asn Arg Asn Arg Gln Asn Arg Gln Glu Asn Lys Tyr Trp Asp Ile Gln 
305                 310                 315                 320 


Ile Gly Tyr Gln Thr Arg Glu Val Met Cys Ile Asn Lys Thr Gly Lys 
                325                 330                 335     


Ala Ala Asp Leu Ser Phe Cys Gln Gln Glu Lys Leu Pro Met Thr Phe 
            340                 345                 350         


Gln Ser Cys Val Ile Thr Lys Glu Cys Gln Val Ser Glu Trp Ser Glu 
        355                 360                 365             


Trp Ser Pro Cys Ser Lys Thr Cys His Asp Met Val Ser Pro Ala Gly 
    370                 375                 380                 


Thr Arg Val Arg Thr Arg Thr Ile Arg Gln Phe Pro Ile Gly Ser Glu 
385                 390                 395                 400 


Lys Glu Cys Pro Glu Phe Glu Glu Lys Glu Pro Cys Leu Ser Gln Gly 
                405                 410                 415     


Asp Gly Val Val Pro Cys Ala Thr Tyr Gly Trp Arg Thr Thr Glu Trp 
            420                 425                 430         


Thr Glu Cys Arg Val Asp Pro Leu Leu Ser Gln Gln Asp Lys Arg Arg 
        435                 440                 445             


Gly Asn Gln Thr Ala Leu Cys Gly Gly Gly Ile Gln Thr Arg Glu Val 
    450                 455                 460                 


Tyr Cys Val Gln Ala Asn Glu Asn Leu Leu Ser Gln Leu Ser Thr His 
465                 470                 475                 480 


Lys Asn Lys Glu Ala Ser Lys Pro Met Asp Leu Lys Leu Cys Thr Gly 
                485                 490                 495     


Pro Ile Pro Asn Thr Thr Gln Leu Cys His Ile Pro Cys Pro Thr Glu 
            500                 505                 510         


Cys Glu Val Ser Pro Trp Ser Ala Trp Gly Pro Cys Thr Tyr Glu Asn 
        515                 520                 525             


Cys Asn Asp Gln Gln Gly Lys Lys Gly Phe Lys Leu Arg Lys Arg Arg 
    530                 535                 540                 


Ile Thr Asn Glu Pro Thr Gly Gly Ser Gly Val Thr Gly Asn Cys Pro 
545                 550                 555                 560 


His Leu Leu Glu Ala Ile Pro Cys Glu Glu Pro Ala Cys Tyr Asp Trp 
                565                 570                 575     


Lys Ala Val Arg Leu Gly Asn Cys Glu Pro Asp Asn Gly Lys Glu Cys 
            580                 585                 590         


Gly Pro Gly Thr Gln Val Gln Glu Val Val Cys Ile Asn Ser Asp Gly 
        595                 600                 605             


Glu Glu Val Asp Arg Gln Leu Cys Arg Asp Ala Ile Phe Pro Ile Pro 
    610                 615                 620                 


Val Ala Cys Asp Ala Pro Cys Pro Lys Asp Cys Val Leu Ser Thr Trp 
625                 630                 635                 640 


Ser Thr Trp Ser Ser Cys Ser His Thr Cys Ser Gly Lys Thr Thr Glu 
                645                 650                 655     


Gly Lys Gln Ile Arg Ala Arg Ser Ile Leu Ala Tyr Ala Gly Glu Glu 
            660                 665                 670         


Gly Gly Ile Arg Cys Pro Asn Ser Ser Ala Leu Gln Glu Val Arg Ser 
        675                 680                 685             


Cys Asn Glu His Pro Cys Thr Val Tyr His Trp Gln Thr Gly Pro Trp 
    690                 695                 700                 


Gly Gln Cys Ile Glu Asp Thr Ser Val Ser Ser Phe Asn Thr Thr Thr 
705                 710                 715                 720 


Thr Trp Asn Gly Glu Ala Ser Cys Ser Val Gly Met Gln Thr Arg Lys 
                725                 730                 735     


Val Ile Cys Val Arg Val Asn Val Gly Gln Val Gly Pro Lys Lys Cys 
            740                 745                 750         


Pro Glu Ser Leu Arg Pro Glu Thr Val Arg Pro Cys Leu Leu Pro Cys 
        755                 760                 765             


Lys Lys Asp Cys Ile Val Thr Pro Tyr Ser Asp Trp Thr Ser Cys Pro 
    770                 775                 780                 


Ser Ser Cys Lys Glu Gly Asp Ser Ser Ile Arg Lys Gln Ser Arg His 
785                 790                 795                 800 


Arg Val Ile Ile Gln Leu Pro Ala Asn Gly Gly Arg Asp Cys Thr Asp 
                805                 810                 815     


Pro Leu Tyr Glu Glu Lys Ala Cys Glu Ala Pro Gln Ala Cys Gln Ser 
            820                 825                 830         


Tyr Arg Trp Lys Thr His Lys Trp Arg Arg Cys Gln Leu Val Pro Trp 
        835                 840                 845             


Ser Val Gln Gln Asp Ser Pro Gly Ala Gln Glu Gly Cys Gly Pro Gly 
    850                 855                 860                 


Arg Gln Ala Arg Ala Ile Thr Cys Arg Lys Gln Asp Gly Gly Gln Ala 
865                 870                 875                 880 


Gly Ile His Glu Cys Leu Gln Tyr Ala Gly Pro Val Pro Ala Leu Thr 
                885                 890                 895     


Gln Ala Cys Gln Ile Pro Cys Gln Asp Asp Cys Gln Leu Thr Ser Trp 
            900                 905                 910         


Ser Lys Phe Ser Ser Cys Asn Gly Asp Cys Gly Ala Val Arg Thr Arg 
        915                 920                 925             


Lys Arg Thr Leu Val Gly Lys Ser Lys Lys Lys Glu Lys Cys Lys Asn 
    930                 935                 940                 


Ser His Leu Tyr Pro Leu Ile Glu Thr Gln Tyr Cys Pro Cys Asp Lys 
945                 950                 955                 960 


Tyr Asn Ala Gln Pro Val Gly Asn Trp Ser Asp Cys Ile Leu Pro Glu 
                965                 970                 975     


Gly Lys Val Glu Val Leu Leu Gly Met Lys Val Gln Gly Asp Ile Lys 
            980                 985                 990         


Glu Cys Gly Gln Gly Tyr Arg Tyr  Gln Ala Met Ala Cys  Tyr Asp Gln 
        995                 1000                 1005             


Asn Gly  Arg Leu Val Glu Thr  Ser Arg Cys Asn Ser  His Gly Tyr 
    1010                 1015                 1020             


Ile Glu  Glu Ala Cys Ile Ile  Pro Cys Pro Ser Asp  Cys Lys Leu 
    1025                 1030                 1035             


Ser Glu  Trp Ser Asn Trp Ser  Arg Cys Ser Lys Ser  Cys Gly Ser 
    1040                 1045                 1050             


Gly Val  Lys Val Arg Ser Lys  Trp Leu Arg Glu Lys  Pro Tyr Asn 
    1055                 1060                 1065             


Gly Gly  Arg Pro Cys Pro Lys  Leu Asp His Val Asn  Gln Ala Gln 
    1070                 1075                 1080             


Val Tyr  Glu Val Val Pro Cys  His Ser Asp Cys Asn  Gln Tyr Leu 
    1085                 1090                 1095             


Trp Val  Thr Glu Pro Trp Ser  Ile Cys Lys Val Thr  Phe Val Asn 
    1100                 1105                 1110             


Met Arg  Glu Asn Cys Gly Glu  Gly Val Gln Thr Arg  Lys Val Arg 
    1115                 1120                 1125             


Cys Met  Gln Asn Thr Ala Asp  Gly Pro Ser Glu His  Val Glu Asp 
    1130                 1135                 1140             


Tyr Leu  Cys Asp Pro Glu Glu  Met Pro Leu Gly Ser  Arg Val Cys 
    1145                 1150                 1155             


Lys Leu  Pro Cys Pro Glu Asp  Cys Val Ile Ser Glu  Trp Gly Pro 
    1160                 1165                 1170             


Trp Thr  Gln Cys Val Leu Pro  Cys Asn Gln Ser Ser  Phe Arg Gln 
    1175                 1180                 1185             


Arg Ser  Ala Asp Pro Ile Arg  Gln Pro Ala Asp Glu  Gly Arg Ser 
    1190                 1195                 1200             


Cys Pro  Asn Ala Val Glu Lys  Glu Pro Cys Asn Leu  Asn Lys Asn 
    1205                 1210                 1215             


Cys Tyr  His Tyr Asp Tyr Asn  Val Thr Asp Trp Ser  Thr Cys Gln 
    1220                 1225                 1230             


Leu Ser  Glu Lys Ala Val Cys  Gly Asn Gly Ile Lys  Thr Arg Met 
    1235                 1240                 1245             


Leu Asp  Cys Val Arg Ser Asp  Gly Lys Ser Val Asp  Leu Lys Tyr 
    1250                 1255                 1260             


Cys Glu  Ala Leu Gly Leu Glu  Lys Asn Trp Gln Met  Asn Thr Ser 
    1265                 1270                 1275             


Cys Met  Val Glu Cys Pro Val  Asn Cys Gln Leu Ser  Asp Trp Ser 
    1280                 1285                 1290             


Pro Trp  Ser Glu Cys Ser Gln  Thr Cys Gly Leu Thr  Gly Lys Met 
    1295                 1300                 1305             


Ile Arg  Arg Arg Thr Val Thr  Gln Pro Phe Gln Gly  Asp Gly Arg 
    1310                 1315                 1320             


Pro Cys  Pro Ser Leu Met Asp  Gln Ser Lys Pro Cys  Pro Val Lys 
    1325                 1330                 1335             


Pro Cys  Tyr Arg Trp Gln Tyr  Gly Gln Trp Ser Pro  Cys Gln Val 
    1340                 1345                 1350             


Gln Glu  Ala Gln Cys Gly Glu  Gly Thr Arg Thr Arg  Asn Ile Ser 
    1355                 1360                 1365             


Cys Val  Val Ser Asp Gly Ser  Ala Asp Asp Phe Ser  Lys Val Val 
    1370                 1375                 1380             


Asp Glu  Glu Phe Cys Ala Asp  Ile Glu Leu Ile Ile  Asp Gly Asn 
    1385                 1390                 1395             


Lys Asn  Met Val Leu Glu Glu  Ser Cys Ser Gln Pro  Cys Pro Gly 
    1400                 1405                 1410             


Asp Cys  Tyr Leu Lys Asp Trp  Ser Ser Trp Ser Leu  Cys Gln Leu 
    1415                 1420                 1425             


Thr Cys  Val Asn Gly Glu Asp  Leu Gly Phe Gly Gly  Ile Gln Val 
    1430                 1435                 1440             


Arg Ser  Arg Pro Val Ile Ile  Gln Glu Leu Glu Asn  Gln His Leu 
    1445                 1450                 1455             


Cys Pro  Glu Gln Met Leu Glu  Thr Lys Ser Cys Tyr  Asp Gly Gln 
    1460                 1465                 1470             


Cys Tyr  Glu Tyr Lys Trp Met  Ala Ser Ala Trp Lys  Gly Ser Ser 
    1475                 1480                 1485             


Arg Thr  Val Trp Cys Gln Arg  Ser Asp Gly Ile Asn  Val Thr Gly 
    1490                 1495                 1500             


Gly Cys  Leu Val Met Ser Gln  Pro Asp Ala Asp Arg  Ser Cys Asn 
    1505                 1510                 1515             


Pro Pro  Cys Ser Gln Pro His  Ser Tyr Cys Ser Glu  Thr Lys Thr 
    1520                 1525                 1530             


Cys His  Cys Glu Glu Gly Tyr  Thr Glu Val Met Ser  Ser Asn Ser 
    1535                 1540                 1545             


Thr Leu  Glu Gln Cys Thr Leu  Ile Pro Val Val Val  Leu Pro Thr 
    1550                 1555                 1560             


Met Glu  Asp Lys Arg Gly Asp  Val Lys Thr Ser Arg  Ala Val His 
    1565                 1570                 1575             


Pro Thr  Gln Pro Ser Ser Asn  Pro Ala Gly Arg Gly  Arg Thr Trp 
    1580                 1585                 1590             


Phe Leu  Gln Pro Phe Gly Pro  Asp Gly Arg Leu Lys  Thr Trp Val 
    1595                 1600                 1605             


Tyr Gly  Val Ala Ala Gly Ala  Phe Val Leu Leu Ile  Phe Ile Val 
    1610                 1615                 1620             


Ser Met  Ile Tyr Leu Ala Cys  Lys Lys Pro Lys Lys  Pro Gln Arg 
    1625                 1630                 1635             


Arg Gln  Asn Asn Arg Leu Lys  Pro Leu Thr Leu Ala  Tyr Asp Gly 
    1640                 1645                 1650             


Asp Ala  Asp Met 
    1655         


<210>  447
<211>  2799
<212>  DNA
<213>  Homo Sapiens

<400>  447
agcttcgagg ccagtgggag gagggagggg ccaggcagct gagggccagg aaagatgtga       60

aaaactctag ctggtgaccg agaggaggag tagagtgtgc ccttagttca tatgaactag      120

agggagttgg tatttgcaca gcagtcaggg tcacatgagt gatcatggta cagtgagaag      180

ttctccctcc cagggccagg tcacagggtt tgtttctgtt caatccggat tcttccagta      240

aaagcttcaa cttcccacac tgaagctgag agcctcccaa agtgctggct acctgctgag      300

cgcccccgta actctgacac agtagtaatt tgagcctctg caattgccgt ctgcttcctg      360

tgaaagtcct ttccgtgccc actgaccctt gagtgggcct ttgagctgct gactttcagc      420

tggaacttga agggacccca accctgagac actatggccc tgacctcaga cctggggaaa      480

cagataaaac tgaaagaggt ggaggggacc ctcctgcagc ctgcaactgt ggacaactgg      540

agccagatcc agagcttcga ggccaaacca gatgatctcc tcatctgcac ctaccctaaa      600

gcagggacaa cgtggattca ggaaattgtg gatatgattg aacagaatgg ggacgtggag      660

aagtgccagc gagccatcat ccaacaccgc catcctttca ttgagtgggc tcggccaccc      720

caaccttctg gtgtggaaaa agccaaagca atgccctctc cacggatact aaagactcac      780

ctttccactc agctgctgcc accgtctttc tgggaaaaca actgcaagtt cctttatgta      840

gctcgaaatg ccaaagactg tatggtttcc tactaccatt tccaaaggat gaaccacatg      900

cttcctgacc ctggtacctg ggaagagtat tttgaaacct tcatcaatgg aaaagtggtt      960

tggggttcct ggtttgacca cgtgaaagga tggtgggaga tgaaagacag acaccagatt     1020

ctcttcctct tctatgagga cataaagagg gacccaaagc atgaaattcg gaaggtgatg     1080

cagttcatgg gaaagaaggt ggatgaaaca gtgctagata aaattgtcca ggagacgtca     1140

tttgagaaaa tgaaagaaaa tcccatgaca aatcgttcta cagtttccaa atctatcttg     1200

gaccagtcaa tttcctcctt catgagaaaa ggaactgtgg gggattggaa aaaccacttc     1260

actgttgccc agaatgagag gtttgatgaa atctatagaa gaaagatgga aggaacctcc     1320

ataaacttct gcatggaact ctgagcaaga tgtaaataaa attaaaaggt ggatggcaag     1380

agtgcaaata ctatcttcaa tccttcagtc ccagccagaa gaatctctga aagcatattg     1440

tgaatgtata caatgtagta caaacaatct ctgtgatgat taacagtatg tcaccacttc     1500

attttttaaa aaggatcacg tctaatgccc attttcccaa ctattctttc caaagtaaga     1560

tataaggtag cttaataaac taagtaaaac gtatgacttg agtacaaaag gattgtttta     1620

atccccatta ttctggaaag tgcatcctag tctcccagtc tataacatca taataccttg     1680

agtataagtc caaatattag gttatatcta tattaaaaac aaaatttctg tcatctgtcc     1740

tggccattca ggcaactcca gcctgggctc aatcctggag ttctgtctgg tcactatcag     1800

aaggaacact ttgagggaaa ccctggtgca gccagccctg aggaaacatg gcctgagtgc     1860

cctcactggt gggtgggaat aaaatggaag tgcacagagg agatgtcaga agaccaaaac     1920

ttggtgaata gtcccagtgc taggtcatat aggaaacaga aagcatgaca gtggcctttt     1980

gggaacccaa gttacgtcct ggtgaaagca gaaaggagga gacaggatgg ctgtcaacaa     2040

cgtcagcatg ggcatggctc ccaggcatgg aggtaattgg gtcttggctt caatgccacc     2100

cttttgggaa gccctaaacc aagtgaggtg ttcttttccc ttgcttccca tatttgtccc     2160

agttgcagcc ctgttgttat gtatttactc ttcaatttct tatttatacc tctcactcaa     2220

ttgttaattc tttgggttca gtctcatgcc atatttactc ctagtaccta atgcagtgcc     2280

tggcacacag caagtgccct tgagaacttg tagagggagt aaaaaagtgc atggataaat     2340

gactgcagca aatcacaaat tttgaacttt gacccttttc ttttagtccc aaatagtggc     2400

attccatagc tgagggtagt aggagcagtt caccctggga gcagacaata agaggaagaa     2460

tgaagccaac taaaattctg aatgcttttt gttggatttc gtagggtatt ttttttaaaa     2520

tagggtcttg ctatgttgcc caggctggtc ttaactgact gctttttatt attaccatgc     2580

actggcaatt ccaaacaatg tcagtgttaa aatgcttctc cctgaaaaag agaaaaaaaa     2640

aaggaaaaaa agaaaagaaa agtgaaaaga aaaactctta ttggcctaag ttctaaataa     2700

tagctaggtt accactgagt tttaactata tgtatatgag cttcaaataa gcaccttttt     2760

attatgtaaa taaataaaag ttatctgtat ccccaaaaa                            2799


<210>  448
<211>  296
<212>  PRT
<213>  Homo Sapiens

<400>  448

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Gly Val Glu Lys 
                85                  90                  95      


Ala Lys Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr 
            100                 105                 110         


Gln Leu Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr 
        115                 120                 125             


Val Ala Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln 
    130                 135                 140                 


Arg Met Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe 
145                 150                 155                 160 


Glu Thr Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His 
                165                 170                 175     


Val Lys Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu 
            180                 185                 190         


Phe Tyr Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val 
        195                 200                 205             


Met Gln Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile 
    210                 215                 220                 


Val Gln Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn 
225                 230                 235                 240 


Arg Ser Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr 
        275                 280                 285             


Ser Ile Asn Phe Cys Met Glu Leu 
    290                 295     


<210>  449
<211>  2387
<212>  DNA
<213>  Homo Sapiens

<400>  449
agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct       60

gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga      120

cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta      180

cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct      240

ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat      300

gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct      360

caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg      420

ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct      480

caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga      540

gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc      600

tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa      660

gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt      720

catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc      780

ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga      840

gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt      900

ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg      960

cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga     1020

ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct     1080

gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc     1140

taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag     1200

tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt     1260

gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga     1320

cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc     1380

aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac     1440

tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac     1500

aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga     1560

tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt     1620

caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt     1680

ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg     1740

gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc     1800

ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac     1860

cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag     1920

gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt     1980

ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg     2040

ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt     2100

gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt     2160

ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat     2220

acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt     2280

ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2387


<210>  450
<211>  707
<212>  PRT
<213>  Homo Sapiens

<400>  450

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210>  451
<211>  1865
<212>  DNA
<213>  Homo Sapiens

<400>  451
aaaattagaa ctaggctgac attacatttc acttggttac agctgactgg ggattttaat       60

catttggagc cacactgaaa aaaaaatttc cccctgcaat ctactcttaa ctgatagtcg      120

ctaactttgg ttatgtgtgt ctattcagaa tattacatta attgatttct caaacaaagg      180

tcctttctga aatggtatct atgattcagc tattcaaaac ctaatgaagt tggtgactat      240

gacaatgtgg agaaatcatg acagaaaatg tggtttgtac tggggctgtc aatgctgtaa      300

aggaagtttg ggaaaaaaga ataaagaaac tcaatgaaga cctgaagcga gagaaggaat      360

ttcaacacaa gctagtgcgg atctgggaag aacgagtaag cttaaccaag ctaagagaaa      420

aggtcaccag ggaagatgga agagtcattt tgaagataga aaaagaggaa tggaagaccc      480

tcccttcttc tctgctgaaa ctgaatcaac tacaggaatg gcaacttcat agaactggtt      540

tgctgaaaat tcctgaattc attggaagat tccagaacct cattgtgtta gatttatctc      600

gaaacacaat ttcagagata ccaccaggga ttggactgct tactagactt caggaactga      660

ttctcagcta caacaaaatc aagactgtcc ccaaggaact aagtaattgt gccagcttgg      720

agaaactaga actggctgtt aacagagata tatgtgatct tccacaagag ctcagcaatc      780

tgctaaaact tactcacctt gatctgagta tgaacgattt tactacaatc cctcttgctg      840

tgttgaacat gcctgccctt gagtggctgg acatgggaag caacaaactt gaacaacttc      900

ctgatactat agaaagaatg caaaatctac atacgttatg gctgcaacga aatgaaataa      960

catgcttgcc tcaaacaatc agcaatatga aaaatctggg tactcttgtt ctcagcaaca     1020

ataaactgca agatattcca gtatgcatgg aagaaatggc aaatctgagg tttgtcaact     1080

tcagagacaa cccactgaaa ttgaaagtat cacttcctcc cagtgaaggc acagatgaag     1140

aagaggaacg ggaattattt ggccttcagt ttatgcacac atacatacaa gagtcacgga     1200

gaagagcaga tcaccaagtc aacggttcaa ctactttacc aatctccata aatacggatg     1260

gataatataa ttcaagatgc ccttctaaag aggattactt tggtgaattc tctaatgttt     1320

ggatttctga agtaaaaaga aaagctatta ccaaagttta atgaggccac agcatttttt     1380

aaagttcata ttatttgcta tttaaagtat atattttttt gatataaaaa tataattaaa     1440

aaattttttt tggtggaaga cagatgatgc tcaaatttct tttccattaa gcagttgttt     1500

ctggtgatga agaatgattt ggtaaagcag ttaacaaaac attttccaaa gacaccagag     1560

ggtctgtata gtactgcaaa gcaggactga atcccttctg ctgcaaatac tggattcgac     1620

cttggtcaat cagcaattta caaagatgcc ctattttctt cttttcttca acactaagaa     1680

gcctaaattg aataaacaca cacaaaacat tgttaaaatt ttgcaaaagt ttataaaaaa     1740

ttatttttgt cactatttat tgagagactg ttaactaacc cataatgtac taagtacttt     1800

gtcccatgct tccaagacac attatattta tgaccacaat aaaagatgtg tatattttaa     1860

aaaaa                                                                 1865


<210>  452
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  452

Met Thr Glu Asn Val Val Cys Thr Gly Ala Val Asn Ala Val Lys Glu 
1               5                   10                  15      


Val Trp Glu Lys Arg Ile Lys Lys Leu Asn Glu Asp Leu Lys Arg Glu 
            20                  25                  30          


Lys Glu Phe Gln His Lys Leu Val Arg Ile Trp Glu Glu Arg Val Ser 
        35                  40                  45              


Leu Thr Lys Leu Arg Glu Lys Val Thr Arg Glu Asp Gly Arg Val Ile 
    50                  55                  60                  


Leu Lys Ile Glu Lys Glu Glu Trp Lys Thr Leu Pro Ser Ser Leu Leu 
65                  70                  75                  80  


Lys Leu Asn Gln Leu Gln Glu Trp Gln Leu His Arg Thr Gly Leu Leu 
                85                  90                  95      


Lys Ile Pro Glu Phe Ile Gly Arg Phe Gln Asn Leu Ile Val Leu Asp 
            100                 105                 110         


Leu Ser Arg Asn Thr Ile Ser Glu Ile Pro Pro Gly Ile Gly Leu Leu 
        115                 120                 125             


Thr Arg Leu Gln Glu Leu Ile Leu Ser Tyr Asn Lys Ile Lys Thr Val 
    130                 135                 140                 


Pro Lys Glu Leu Ser Asn Cys Ala Ser Leu Glu Lys Leu Glu Leu Ala 
145                 150                 155                 160 


Val Asn Arg Asp Ile Cys Asp Leu Pro Gln Glu Leu Ser Asn Leu Leu 
                165                 170                 175     


Lys Leu Thr His Leu Asp Leu Ser Met Asn Asp Phe Thr Thr Ile Pro 
            180                 185                 190         


Leu Ala Val Leu Asn Met Pro Ala Leu Glu Trp Leu Asp Met Gly Ser 
        195                 200                 205             


Asn Lys Leu Glu Gln Leu Pro Asp Thr Ile Glu Arg Met Gln Asn Leu 
    210                 215                 220                 


His Thr Leu Trp Leu Gln Arg Asn Glu Ile Thr Cys Leu Pro Gln Thr 
225                 230                 235                 240 


Ile Ser Asn Met Lys Asn Leu Gly Thr Leu Val Leu Ser Asn Asn Lys 
                245                 250                 255     


Leu Gln Asp Ile Pro Val Cys Met Glu Glu Met Ala Asn Leu Arg Phe 
            260                 265                 270         


Val Asn Phe Arg Asp Asn Pro Leu Lys Leu Lys Val Ser Leu Pro Pro 
        275                 280                 285             


Ser Glu Gly Thr Asp Glu Glu Glu Glu Arg Glu Leu Phe Gly Leu Gln 
    290                 295                 300                 


Phe Met His Thr Tyr Ile Gln Glu Ser Arg Arg Arg Ala Asp His Gln 
305                 310                 315                 320 


Val Asn Gly Ser Thr Thr Leu Pro Ile Ser Ile Asn Thr Asp Gly 
                325                 330                 335 


<210>  453
<211>  626
<212>  DNA
<213>  Homo Sapiens

<400>  453
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc       60

tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag      120

ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg      180

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc      240

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg      300

gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact      360

tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca      420

ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc      480

acaagtatca ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc      540

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc      600

taataaaaaa catttatttt cattgc                                           626


<210>  454
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  454

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  455
<211>  1825
<212>  DNA
<213>  Homo Sapiens

<400>  455
acacatgctg catacacaca gaaacactgc aaatccactg cctccttccc tcctccctac       60

ccttccttct ctcagcattt ctatccccgc ctcctcctct tacccaaatt ttccagccga      120

tcactggagc tgacttccgc aatcccgatg gaataaatct agcacccctg atggtgtgcc      180

cacactttgc tgccgaaacg aagccagaca acagatttcc atcagcagga tgtgggggct      240

caaggttctg ctgctacctg tggtgagctt tgctctgtac cctgaggaga tactggacac      300

ccactgggag ctatggaaga agacccacag gaagcaatat aacaacaagg tggatgaaat      360

ctctcggcgt ttaatttggg aaaaaaacct gaagtatatt tccatccata accttgaggc      420

ttctcttggt gtccatacat atgaactggc tatgaaccac ctgggggaca tgaccagtga      480

agaggtggtt cagaagatga ctggactcaa agtacccctg tctcattccc gcagtaatga      540

caccctttat atcccagaat gggaaggtag agccccagac tctgtcgact atcgaaagaa      600

aggatatgtt actcctgtca aaaatcaggg tcagtgtggt tcctgttggg cttttagctc      660

tgtgggtgcc ctggagggcc aactcaagaa gaaaactggc aaactcttaa atctgagtcc      720

ccagaaccta gtggattgtg tgtctgagaa tgatggctgt ggagggggct acatgaccaa      780

tgccttccaa tatgtgcaga agaaccgggg tattgactct gaagatgcct acccatatgt      840

gggacaggaa gagagttgta tgtacaaccc aacaggcaag gcagctaaat gcagagggta      900

cagagagatc cccgagggga atgagaaagc cctgaagagg gcagtggccc gagtgggacc      960

tgtctctgtg gccattgatg caagcctgac ctccttccag ttttacagca aaggtgtgta     1020

ttatgatgaa agctgcaata gcgataatct gaaccatgcg gttttggcag tgggatatgg     1080

aatccagaag ggaaacaagc actggataat taaaaacagc tggggagaaa actggggaaa     1140

caaaggatat atcctcatgg ctcgaaataa gaacaacgcc tgtggcattg ccaacctggc     1200

cagcttcccc aagatgtgac tccagccagc caaatccatc ctgctcttcc atttcttcca     1260

cgatggtgca gtgtaacgat gcactttgga agggagttgg tgtgctattt ttgaagcaga     1320

tgtggtgata ctgagattgt ctgttcagtt tccccatttg tttgtgcttc aaatgatcct     1380

tcctactttg cttctctcca cccatgacct ttttcactgt ggccatcagg actttccctg     1440

acagctgtgt actcttaggc taagagatgt gactacagcc tgcccctgac tgtgttgtcc     1500

cagggctgat gctgtacagg tacaggctgg agattttcac ataggttaga ttctcattca     1560

cgggactagt tagctttaag caccctagag gactagggta atctgacttc tcacttccta     1620

agttcccttc tatatcctca aggtagaaat gtctatgttt tctactccaa ttcataaatc     1680

tattcataag tctttggtac aagtttacat gataaaaaga aatgtgattt gtcttccctt     1740

ctttgcactt ttgaaataaa gtatttatct cctgtctaca gtttaataaa tagcatctag     1800

tacacattca aaaaaaaaaa aaaaa                                           1825


<210>  456
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  456

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  457
<211>  1097
<212>  DNA
<213>  Homo Sapiens

<400>  457
gccgtcggag cccttgcacg cctgctctct tgtagcttct ctcagcctag cccagcatca       60

ctatggtgga cgctttcctg ggcacctgga agctagtgga cagcaagaat ttcgatgact      120

acatgaagtc actcggtgtg ggttttgcta ccaggcaggt ggccagcatg accaagccta      180

ccacaatcat cgaaaagaat ggggacattc tcaccctaaa aacacacagc accttcaaga      240

acacagagat cagctttaag ttgggggtgg agttcgatga gacaacagca gatgacagga      300

aggtcaagtc cattgtgaca ctggatggag ggaaacttgt tcacctgcag aaatgggacg      360

ggcaagagac cacacttgtg cgggagctaa ttgatggaaa actcatcctg acactcaccc      420

acggcactgc agtttgcact cgcacttatg agaaagaggc atgacctgac tgcactgttg      480

ctgactacta ctctgccaat cggctacccc tcgactcagc accacattgc ctcatttctt      540

cctctgcatt ttgtacaaat ccacgaattc ttctggggtc aggtgccact gaccgggatc      600

cagttccagt tcccatggtg tatgtggttt tttttttttt tttttaactg cactcatagg      660

gtgctctgag gtcaataaag cagagccaag gccacccagt tgcctttttg cctttggtaa      720

cataactctg ggagtcttgg tttatcctgt gtgtcagaga gtgggcagaa ataacggcct      780

gaaggttact gaggaagaag cactggatgg gagactgaaa tggacagtct cggagcctgt      840

taatcagctg atcaccttac acatttaata ataaaagagc tgtacctaca cgttgccttt      900

acactgcccc ccctccatgg tcaaatgacc tagttcagtc agtgatgggg cttccccagg      960

tttggctatt gaactgtcac ttcaggccca tcctacactg aaagctcttg ggtctggctg     1020

ttctctgtga aatgctgtag tctctccctt tccagaattc aggttcaggg cacagaaccc     1080

aggcttgtac catggtg                                                    1097


<210>  458
<211>  133
<212>  PRT
<213>  Homo Sapiens

<400>  458

Met Val Asp Ala Phe Leu Gly Thr Trp Lys Leu Val Asp Ser Lys Asn 
1               5                   10                  15      


Phe Asp Asp Tyr Met Lys Ser Leu Gly Val Gly Phe Ala Thr Arg Gln 
            20                  25                  30          


Val Ala Ser Met Thr Lys Pro Thr Thr Ile Ile Glu Lys Asn Gly Asp 
        35                  40                  45              


Ile Leu Thr Leu Lys Thr His Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Lys Leu Gly Val Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Lys 
65                  70                  75                  80  


Val Lys Ser Ile Val Thr Leu Asp Gly Gly Lys Leu Val His Leu Gln 
                85                  90                  95      


Lys Trp Asp Gly Gln Glu Thr Thr Leu Val Arg Glu Leu Ile Asp Gly 
            100                 105                 110         


Lys Leu Ile Leu Thr Leu Thr His Gly Thr Ala Val Cys Thr Arg Thr 
        115                 120                 125             


Tyr Glu Lys Glu Ala 
    130             


<210>  459
<211>  3278
<212>  DNA
<213>  Homo Sapiens

<400>  459
aatagactaa acccagagcc tcaaagcagt gcactccgtg aaggcaaaga gaacacgctg       60

caaaaggctt tccaagaatc ctcgacatgg caaggaggag ctcgttccag tcgtgtcaga      120

taatatccct gttcactttt gccgttggag tcaatatctg cttaggattc actgcacatc      180

gaattaagag agcagaagga tgggaggaag gtcctcctac agtgctatca gactccccct      240

ggaccaacat ctccggatct tgcaagggca ggtgctttga acttcaagag gctggacctc      300

ctgattgtcg ctgtgacaac ttgtgtaaga gctataccag ttgctgccat gactttgatg      360

agctgtgttt gaagacagcc cgtggctggg agtgtactaa ggacagatgt ggagaagtca      420

gaaatgaaga aaatgcctgt cactgctcag aggactgctt ggccagggga gactgctgta      480

ccaattacca agtggtttgc aaaggagagt cgcattgggt tgatgatgac tgtgaggaaa      540

taaaggccgc agaatgccct gcagggtttg ttcgccctcc attaatcatc ttctccgtgg      600

atggcttccg tgcatcatac atgaagaaag gcagcaaagt catgcctaat attgaaaaac      660

taaggtcttg tggcacacac tctccctaca tgaggccggt gtacccaact aaaacctttc      720

ctaacttata cactttggcc actgggctat atccagaatc acatggaatt gttggcaatt      780

caatgtatga tcctgtattt gatgccactt ttcatctgcg agggcgagag aaatttaatc      840

atagatggtg gggaggtcaa ccgctatgga ttacagccac caagcaaggg gtgaaagctg      900

gaacattctt ttggtctgtt gtcatccctc acgagcggag aatattaacc atattgcagt      960

ggctcaccct gccagatcat gagaggcctt cggtctatgc cttctattct gagcaacctg     1020

atttctctgg acacaaatat ggccctttcg gccctgagga gagtagttat ggctcacctt     1080

ttactccggc taagagacct aagaggaaag ttgcccctaa gaggagacag gaaagaccag     1140

ttgctcctcc aaagaaaaga agaagaaaaa tacataggat ggatcattat gctgcggaaa     1200

ctcgtcagga caaaatgaca aatcctctga gggaaatcga caaaattgtg gggcaattaa     1260

tggatggact gaaacaacta aaactgcatc ggtgtgtcaa cgtcatcttt gtcggagacc     1320

atggaatgga agatgtcaca tgtgatagaa ctgagttctt gagtaattac ctaactaatg     1380

tggatgatat tactttagtg cctggaactc taggaagaat tcgatccaaa tttagcaaca     1440

atgctaaata tgaccccaaa gccattattg ccaatctcac gtgtaaaaaa ccagatcagc     1500

actttaagcc ttacttgaaa cagcaccttc ccaaacgttt gcactatgcc aacaacagaa     1560

gaattgagga tatccattta ttggtggaac gcagatggca tgttgcaagg aaacctttgg     1620

atgtttataa gaaaccatca ggaaaatgct ttttccaggg agaccacgga tttgataaca     1680

aggtcaacag catgcagact gtttttgtag gttatggctc aacatttaag tacaagacta     1740

aagtgcctcc atttgaaaac attgaacttt acaatgttat gtgtgatctc ctgggattga     1800

agccagctcc taataatggg acccatggaa gtttgaatca tctcctgcgc actaatacct     1860

tcaggccaac catgccagag gaagttacca gacccaatta tccagggatt atgtaccttc     1920

agtctgattt tgacctgggc tgcacttgtg atgataaggt agagccaaag aacaagttgg     1980

atgaactcaa caaacggctt catacaaaag ggtctacaga agagagacac ctcctctatg     2040

ggcgacctgc agtgctttat cggactagat atgatatctt atatcacact gactttgaaa     2100

gtggttatag tgaaatattc ctaatgccac tctggacatc atatactgtt tccaaacagg     2160

ctgaggtttc cagcgttcct gaccatctga ccagttgcgt ccggcctgat gtccgtgttt     2220

ctccgagttt cagtcagaac tgtttggcct acaaaaatga taagcagatg tcctacggat     2280

tcctctttcc tccttatctg agctcttcac cagaggctaa atatgatgca ttccttgtaa     2340

ccaatatggt tccaatgtat cctgctttca aacgggtctg gaattatttc caaagggtat     2400

tggtgaagaa atatgcttcg gaaagaaatg gagttaacgt gataagtgga ccaatcttcg     2460

actatgacta tgatggctta catgacacag aagacaaaat aaaacagtac gtggaaggca     2520

gttccattcc tgttccaact cactactaca gcatcatcac cagctgtctg gatttcactc     2580

agcctgccga caagtgtgac ggccctctct ctgtgtcctc cttcatcctg cctcaccggc     2640

ctgacaacga ggagagctgc aatagctcag aggacgaatc aaaatgggta gaagaactca     2700

tgaagatgca cacagctagg gtgcgtgaca ttgaacatct caccagcctg gacttcttcc     2760

gaaagaccag ccgcagctac ccagaaatcc tgacactcaa gacatacctg catacatatg     2820

agagcgagat ttaactttct gagcatctgc agtacagtct tatcaactgg ttgtatattt     2880

ttatattgtt tttgtattta ttaatttgaa accaggacat taaaaatgtt agtattttaa     2940

tcctgtacca aatctgacat attatgcctg aatgactcca ctgtttttct ctaatgcttg     3000

atttaggtag ccttgtgttc tgagtagagc ttgtaataaa tactgcagct tgagttttta     3060

gtggaagctt ctaaatggtg ctgcagattt gatatttgca ttgaggaaat attaattttc     3120

caatgcacag ttgccacatt tagtcctgta ctgtatggaa acactgattt tgtaaagttg     3180

cctttatttg ctgttaactg ttaactatga cagatatatt taagccttat aaaccaatct     3240

taaacataat aaatcacaca ttcagttttt tctggttt                             3278


<210>  460
<211>  915
<212>  PRT
<213>  Homo Sapiens

<400>  460

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Glu Ser Ser Tyr Gly Ser Pro Phe Thr Pro Ala Lys 
                325                 330                 335     


Arg Pro Lys Arg Lys Val Ala Pro Lys Arg Arg Gln Glu Arg Pro Val 
            340                 345                 350         


Ala Pro Pro Lys Lys Arg Arg Arg Lys Ile His Arg Met Asp His Tyr 
        355                 360                 365             


Ala Ala Glu Thr Arg Gln Asp Lys Met Thr Asn Pro Leu Arg Glu Ile 
    370                 375                 380                 


Asp Lys Ile Val Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu 
385                 390                 395                 400 


His Arg Cys Val Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp 
                405                 410                 415     


Val Thr Cys Asp Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val 
            420                 425                 430         


Asp Asp Ile Thr Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys 
        435                 440                 445             


Phe Ser Asn Asn Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu 
    450                 455                 460                 


Thr Cys Lys Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His 
465                 470                 475                 480 


Leu Pro Lys Arg Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile 
                485                 490                 495     


His Leu Leu Val Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp 
            500                 505                 510         


Val Tyr Lys Lys Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly 
        515                 520                 525             


Phe Asp Asn Lys Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly 
    530                 535                 540                 


Ser Thr Phe Lys Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu 
545                 550                 555                 560 


Leu Tyr Asn Val Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn 
                565                 570                 575     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe 
            580                 585                 590         


Arg Pro Thr Met Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile 
        595                 600                 605             


Met Tyr Leu Gln Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys 
    610                 615                 620                 


Val Glu Pro Lys Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr 
625                 630                 635                 640 


Lys Gly Ser Thr Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val 
                645                 650                 655     


Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser 
            660                 665                 670         


Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
        675                 680                 685             


Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys 
    690                 695                 700                 


Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu 
705                 710                 715                 720 


Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro 
                725                 730                 735     


Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr 
            740                 745                 750         


Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe 
        755                 760                 765             


Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn 
    770                 775                 780                 


Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp 
785                 790                 795                 800 


Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val 
                805                 810                 815     


Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln 
            820                 825                 830         


Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu 
        835                 840                 845             


Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu 
    850                 855                 860                 


Ser Lys Trp Val Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg 
865                 870                 875                 880 


Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg 
                885                 890                 895     


Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu 
            900                 905                 910         


Ser Glu Ile 
        915 


<210>  461
<211>  1524
<212>  DNA
<213>  Homo Sapiens

<400>  461
agcagacaga ggactctcat taaggaaggt gtcctgtgcc ctgaccctac aagatgccaa       60

gagaagatgc tcacttcatc tatggttacc ccaagaaggg gcacggccac tcttacacca      120

cggctgaaga ggccgctggg atcggcatcc tgacagtgat cctgggagtc ttactgctca      180

tcggctgttg gtattgtaga agacgaaatg gatacagagc cttgatggat aaaagtcttc      240

atgttggcac tcaatgtgcc ttaacaagaa gatgcccaca agaagggttt gatcatcggg      300

acagcaaagt gtctcttcaa gagaaaaact gtgaacctgt ggttcccaat gctccacctg      360

cttatgagaa actctctgca gaacagtcac caccacctta ttcaccttaa gagccagcga      420

gacacctgag acatgctgaa attatttctc tcacactttt gcttgaattt aatacagaca      480

tctaatgttc tcctttggaa tggtgtagga aaaatgcaag ccatctctaa taataagtca      540

gtgttaaaat tttagtaggt ccgctagcag tactaatcat gtgaggaaat gatgagaaat      600

attaaattgg gaaaactcca tcaataaatg ttgcaatgca tgatactatc tgtgccagag      660

gtaatgttag taaatccatg gtgttatttt ctgagagaca gaattcaagt gggtattctg      720

gggccatcca atttctcttt acttgaaatt tggctaataa caaactagtc aggttttcga      780

accttgaccg acatgaactg tacacagaat tgttccagta ctatggagtg ctcacaaagg      840

atacttttac aggttaagac aaagggttga ctggcctatt tatctgatca agaacatgtc      900

agcaatgtct ctttgtgctc taaaattcta ttatactaca ataatatatt gtaaagatcc      960

tatagctctt tttttttgag atggagtttc gcttttgttg cccaggctgg agtgcaatgg     1020

cgcgatcttg gctcaccata acctccgcct cccaggttca agcaattctc ctgccttagc     1080

ctcctgagta gctgggatta caggcgtgcg ccactatgcc tgactaattt tgtagtttta     1140

gtagagacgg ggtttctcca tgttggtcag gctggtctca aactcctgac ctcaggtgat     1200

ctgcccgcct cagcctccca aagtgctgga attacaggcg tgagccacca cgcctggctg     1260

gatcctatat cttaggtaag acatataacg cagtctaatt acatttcact tcaaggctca     1320

atgctattct aactaatgac aagtattttc tactaaacca gaaattggta gaaggattta     1380

aataagtaaa agctactatg tactgcctta gtgctgatgc ctgtgtactg ccttaaatgt     1440

acctatggca atttagctct cttgggttcc caaatccctc tcacaagaat gtgcagaaga     1500

aatcataaag gatcagagat tctg                                            1524


<210>  462
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  462

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  463
<211>  3349
<212>  DNA
<213>  Homo Sapiens

<400>  463
agttggtgtc atgcaagaat ctattcacac tgactaaaga tattggaaga gtgaagatca       60

gagaatttta agtctgaaat ttggcatcac tgccctgaac aatataacct tagttggcat      120

aaactactca tacagacaaa ggcattatcc atcacaataa gtaacttttt gtctttattt      180

caaccggaca atcgtgatta gaaaagctcc tgtgacaaaa ttcaagaaaa cctgacataa      240

atgaacaaca atacaacatg tattcaacca tctatgatct cttccatggc tttaccaatc      300

atttacatcc tcctttgtat tgttggtgtt tttggaaaca ctctctctca atggatattt      360

ttaacaaaaa taggtaaaaa aacatcaacg cacatctacc tgtcacacct tgtgactgca      420

aacttacttg tgtgcagtgc catgcctttc atgagtatct atttcctgaa aggtttccaa      480

tgggaatatc aatctgctca atgcagagtg gtcaattttc tgggaactct atccatgcat      540

gcaagtatgt ttgtcagtct cttaatttta agttggattg ccataagccg ctatgctacc      600

ttaatgcaaa aggattcctc gcaagagact acttcatgct atgagaaaat attttatggc      660

catttactga aaaaatttcg ccagcccaac tttgctagaa aactatgcat ttacatatgg      720

ggagttgtac tgggcataat cattccagtt accgtatact actcagtcat agaggctaca      780

gaaggagaag agagcctatg ctacaatcgg cagatggaac taggagccat gatctctcag      840

attgcaggtc tcattggaac cacatttatt ggattttcct ttttagtagt actaacatca      900

tactactctt ttgtaagcca tctgagaaaa ataagaacct gtacgtccat tatggagaaa      960

gatttgactt acagttctgt gaaaagacat cttttggtca tccagattct actaatagtt     1020

tgcttccttc cttatagtat ttttaaaccc attttttatg ttctacacca aagagataac     1080

tgtcagcaat tgaattattt aatagaaaca aaaaacattc tcacctgtct tgcttcggcc     1140

agaagtagca cagaccccat tatatttctt ttattagata aaacattcaa gaagacacta     1200

tataatctct ttacaaagtc taattcagca catatgcaat catatggttg acttttgaat     1260

ggaaaacccc acaatattaa gaaaagcatt catgtgactt tattagggac actaaactac     1320

atcattaaca tgtcacagct tggttgacaa taatcaccaa gaaaatctct ttggttttta     1380

aaaataaata aacatatatt cataaaactc aaaaaacagt tatactgaac gttgagatgg     1440

cagaaacttt cagaagcaaa aattaagcat attgaaagga tcccactcat atgaaactaa     1500

caggctgttt tctgtttaaa ctcaactgtc agtgcttctg ttcagaacac gttatttcat     1560

gactaggata aagaagcaaa tggtttatga cttgtctgct ttctggtagt tagaatacaa     1620

gggtcaatct atggctagtg tttattggta attttaaaat ctttaaaaat aagtagctgg     1680

gcacagtggc ttacgcctgt aatcccagca ctttgggagg ctgaggtggg tggatcattt     1740

tgaggtcagg agttcaagac cagcctgggc aacatggtga aaccctgtct ctactaaaaa     1800

tacaaaaatc agctggacat ggtggtgggc gcctgtaatc ccagctactc gggaggctga     1860

ggcaggagaa tcgcttgagc ccgggacgga ggttgcagtg agcggagatc gtgccactgc     1920

actacagcct gggaggcaga gcgagactct gtctcataaa acaaaacaaa aaaataaaaa     1980

taagtaaaaa aataaataag aaatatcctc attcacatct tacctaaatg catgaataat     2040

acagtgaaaa aaatccaagg ttttataaac atattattta tttgaaatta tctggctcat     2100

gttattgggg agaagcaata ttcattgact atatttttaa agcagatgat acttataaaa     2160

atgcttaaat atttggatta ggctttgtca aagtaaaaag ctatgtcatt atatgcccat     2220

cttcatcaca ttgtgcatat tttcttctgt attcaatata aataatgtta ttagtgacaa     2280

acagtacctg gcagttaatt ttttgtgaaa taaatgaatg aataataagg gagtgtaata     2340

gtattgcagt taagagattg atctctgaag ttatacttct tgggttcaat ctggctctac     2400

tttttattta gctggacaat cttaggcaaa ttaacttatc ctctgtacgt gttaatttct     2460

tcatttgtag agcagaaaat actatcttat ttacagatcc tattattaaa tcagctgtta     2520

ctattatgag tagctaacgc ttagtaagca cttgctgttt gccaagcatt ctacttatat     2580

gctttacata tattatttta atcaccacaa ctctaaagta tactaattta ctgatgaaaa     2640

tattgaagtg ggctgggtgc ggtggctcat gcctgtaatc ccagcactct gggaggccga     2700

ggtgggcaga tcacctgagg tcaggagttc gagactagcc tggccaacat ggcgaaaccc     2760

acctctacta aaaatacaaa aattagctgg gcgtggtggt gtgtgcctgt agtcccagct     2820

acttgggagg ctgaggcaga agaatcactt gaactcggga ggctgaggca ggagaatcac     2880

ttgaactcag gaggcggagg ttgcagtgag ccaagatcat gccattgcac tccagcctgg     2940

gcgacagagt gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaatata     3000

tatatatata tatatatata tgtatgtatg tatgtatatg tgcatagtta agtaaatcac     3060

cccaattttt tctaatattt aagtgaacat ttaaagataa gcatttctta atgttaattt     3120

cttttctttc atgtaatctt gtcagtagac aaatgatggt gactatattc tgtaataagt     3180

acatatatta tgattaaaaa aaaaagcgtg tactatctgc ccaaagagat cataagcact     3240

ttggagctat aaacttcttg tctatttcta cttccatggt actgatattc tcttctcaga     3300

taaccaaaca aaaacagctg aataaaatca accattaata gtaacttgc                 3349


<210>  464
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  464

Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met 
1               5                   10                  15      


Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly 
            20                  25                  30          


Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr 
        35                  40                  45              


Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val 
    50                  55                  60                  


Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln 
65                  70                  75                  80  


Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr 
                85                  90                  95      


Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp 
            100                 105                 110         


Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln 
        115                 120                 125             


Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys 
    130                 135                 140                 


Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp 
145                 150                 155                 160 


Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val 
                165                 170                 175     


Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met 
            180                 185                 190         


Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr 
        195                 200                 205             


Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe 
    210                 215                 220                 


Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys 
225                 230                 235                 240 


Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile 
                245                 250                 255     


Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe 
            260                 265                 270         


Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile 
        275                 280                 285             


Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr 
    290                 295                 300                 


Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu 
305                 310                 315                 320 


Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly 
                325                 330                 335     


<210>  465
<211>  7442
<212>  DNA
<213>  Homo Sapiens

<400>  465
ccggagcggc cggggccacg atggagcgcg acggctgcgc ggggggcggg agccgcggcg       60

gcgagggcgg gcgcgctccc cgggagggcc cggcggggaa cggccgcgat cggggccgca      120

gccacgctgc cgaggcgccc ggggacccgc aggcggccgc gtccttgctg gcccctatgg      180

acgtggggga ggagccgctg gagaaggcgg cgcgcgcccg cactgccaag gaccccaaca      240

cctataaagt actctcgctg gtattgtcag tatgtgtgtt aacaacaata cttggttgta      300

tatttgggtt gaaaccaagc tgtgccaaag aagttaaaag ttgcaaaggt cgctgtttcg      360

agagaacatt tgggaactgt cgctgtgatg ctgcctgtgt tgagcttgga aactgctgtt      420

tagattacca ggagacgtgc atagaaccag aacatatatg gacttgcaac aaattcaggt      480

gtggtgagaa aaggttgacc agaagcctct gtgcctgttc agatgactgc aaggacaagg      540

gcgactgctg catcaactac agttctgtgt gtcaaggtga gaaaagttgg gtagaagaac      600

catgtgagag cattaatgag ccacagtgcc cagcagggtt tgaaacgcct cctaccctct      660

tattttcttt ggatggattc agggcagaat atttacacac ttggggtgga cttcttcctg      720

ttattagcaa actaaaaaaa tgtggaacat atactaaaaa catgagaccg gtatatccaa      780

caaaaacttt ccccaatcac tacagcattg tcaccggatt gtatccagaa tctcatggca      840

taatcgacaa taaaatgtat gatcccaaaa tgaatgcttc cttttcactt aaaagtaaag      900

agaaatttaa tcctgagtgg tacaaaggag aaccaatttg ggtcacagct aagtatcaag      960

gcctcaagtc tggcacattt ttctggccag gatcagatgt ggaaattaac ggaattttcc     1020

cagacatcta taaaatgtat aatggttcag taccatttga agaaaggatt ttagctgttc     1080

ttcagtggct acagcttcct aaagatgaaa gaccacactt ttacactctg tatttagaag     1140

aaccagattc ttcaggtcat tcatatggac cagtcagcag tgaagtcatc aaagccttgc     1200

agagggttga tggtatggtt ggtatgctga tggatggtct gaaagagctg aacttgcaca     1260

gatgcctgaa cctcatcctt atttcagatc atggcatgga acaaggcagt tgtaagaaat     1320

acatatatct gaataaatat ttgggggatg ttaaaaatat taaagttatc tatggacctg     1380

cagctcgatt gagaccctct gatgtcccag ataaatacta ttcatttaac tatgaaggca     1440

ttgcccgaaa tctttcttgc cgggaaccaa accagcactt caaaccttac ctgaaacatt     1500

tcttacctaa gcgtttgcac tttgctaaga gtgatagaat tgagcccttg acattctatt     1560

tggaccctca gtggcaactt gcattgaatc cctcagaaag gaaatattgt ggaagtggat     1620

ttcatggctc tgacaatgta ttttcaaata tgcaagccct ctttgttggc tatggacctg     1680

gattcaagca tggcattgag gctgacacct ttgaaaacat tgaagtctat aacttaatgt     1740

gtgatttact gaatttgaca ccggctccta ataacggaac tcatggaagt cttaaccacc     1800

ttctaaagaa tcctgtttat acgccaaagc atcccaaaga agtgcacccc ctggtacagt     1860

gccccttcac aagaaacccc agagataacc ttggctgctc atgtaaccct tcgattttgc     1920

cgattgagga ttttcaaaca cagttcaatc tgactgtggc agaagagaag attattaagc     1980

atgaaacttt accctatgga agacctagag ttctccagaa ggaaaacacc atctgtcttc     2040

tttcccagca ccagtttatg agtggataca gccaagacat cttaatgccc ctttggacat     2100

cctataccgt ggacagaaat gacagtttct ctacggaaga cttctccaac tgtctgtacc     2160

aggactttag aattcctctt agtcctgtcc ataaatgttc attttataaa aataacacca     2220

aagtgagtta cgggttcctc tccccaccac aactaaataa aaattcaagt ggaatatatt     2280

ctgaagcttt gcttactaca aatatagtgc caatgtacca gagttttcaa gttatatggc     2340

gctactttca tgacacccta ctgcgaaagt atgctgaaga aagaaatggt gtcaatgtcg     2400

tcagtggtcc tgtgtttgac tttgattatg atggacgttg tgattcctta gagaatctga     2460

ggcaaaaaag aagagtcatc cgtaaccaag aaattttgat tccaactcac ttctttattg     2520

tgctaacaag ctgtaaagat acatctcaga cgcctttgca ctgtgaaaac ctagacacct     2580

tagctttcat tttgcctcac aggactgata acagcgagag ctgtgtgcat gggaagcatg     2640

actcctcatg ggttgaagaa ttgttaatgt tacacagagc acggatcaca gatgttgagc     2700

acatcactgg actcagcttc tatcaacaaa gaaaagagcc agtttcagac attttaaagt     2760

tgaaaacaca tttgccaacc tttagccaag aagactgata tgttttttat ccccaaacac     2820

catgaatctt tttgagagaa ccttatattt tatatagtcc tctagctaca ctattgcatt     2880

gttcagaaac tgtcgaccag agttagaacg gagccctcgg tgatgcggac atctcaggga     2940

aacttgcgta ctcagcacag cagtggagag tgttcctgtt gaatcttgca catatttgaa     3000

tgtgtaagca ttgtatacat tgatcaagtt cgggggaata aagacagacc acacctaaaa     3060

ctgcctttct gcttctctta aaggagaagt agctgtgaac attgtctgga taccagatat     3120

ttgaatcttt cttactattg gtaataaacc ttgatggcat tgggcaaaca gtagacttat     3180

agtagggttg gggtagccca tgttatgtga ctatctttat gagaatttta aagtggttct     3240

ggatatcttt taacttggag tttcatttct tttcattgta atcaaaaaaa aaattaacag     3300

aagccaaaat acttctgaga ccttgtttca atctttgctg tatatcccct caaaatccaa     3360

gttattaatc ttatgtgttt tctttttaat tttttgattg gatttcttta gatttaatgg     3420

ttcaaatgag ttcaactttg agggacgatc tttgaatata cttacctatt ataaaatctt     3480

actttgtatt tgtatttaaa aaagaaaaat attcctatcc tgctcactgg taattaacat     3540

aggtttaaaa tggcttcaaa tgtggcccta tagacggtta aaattgtacc ttatcttggc     3600

aaaacttcag agcaccagtc agtgcatgca aggtgccatt ttttattgag atgcttagaa     3660

tgtttctttc tgtgcacaag acttacccta ccagcagcag agccattctc tgttgagtgg     3720

ttcattttga agttccacag attgaagaga acatgccacc aatcacctca catcttcttg     3780

gtggacatga taaatgacac aatgaacttg atttctttac taccttgact gtagcttttt     3840

atccctacct gtgaaccttc aaagactgca ttaactttta ggctacatag gtccaattga     3900

ggtataatat cagtacacca aagattttta tatgtccttc gtgtgaccat tcttcaacgg     3960

cctaagggcc agctgcaaag acttttggaa aatacaattt acaactcaaa attatttaat     4020

aatttaggaa gttgcttttt tttttttttt ttttcagtcc tgcagtttcc tgaagctctg     4080

tatatgatat ttttttcagc ctgcttctct ctgttgttca gattaggtaa ttttattctt     4140

ctgtctcgaa gctcactgat tctttattct gtctaatctg ttctgctgtt gagcccattt     4200

attcctgatt tttatatttt agttattgta tgttttattt ctaaaatttc cattcagttt     4260

ttctttatat cttctatttg ctgagaattt ctgtctcttt gctgagactt tctacgtttt     4320

catttgtttc aagtgcattt atacttgctt gttgaagaat ttttatgatg gctgctgtaa     4380

aatccttatc agataattcc aacatctgtc acctcattgt ttgcatctac tgatggtctt     4440

ttttccattc ggaaacattt tcctgtttct tggtgtgtgg aatgattttt tattgaaacc     4500

tggatatttt taggtattat gttatgagac tatgggtctt atttaaacct tctgctttag     4560

ccaactttct cagataccac cacagcaggg gaattgggag cactgcttca ttattaccag     4620

gtgtggctag gagtccaggt tccccagtca gcctcccttt atactgagta acagggtccc     4680

ctcattacta ctgggcaagg tgagaattca gtttcccatt aggtctttat tgattcttcc     4740

ctggctggaa tgtgcagcgg caccttttgg tgcaccctgg gaatctccac taatgctatg     4800

ggacagagtg accaggaaga gcttcattac accaggtggg aatgaaattc ccagtagcct     4860

acacagcctt ctccgacacc actctggagt tgtattcttc cagcacacaa acatacacaa     4920

tttaactcaa agcatcttag cagagcttaa ttaaatggat agatgcctgt tccctttgct     4980

ggataccaag aatacaaaag tcagggagtt ggggcacctc tttacagctt ggtgagagtg     5040

taagtctgga ctccccactc agcatttgct ggtatgggtg gggccatggt gtttttccat     5100

ggtgtttggt tggagtacag ccttttttac ccttgcttgg ctaccctttt ctggtccttt     5160

ggcaggagag agcaggactc tcttagggct tttttttccc ctgcatttat tgacatttcc     5220

aggttgctga ctttttcagc tccaagttgg aaatatatga gctgaaaaga aaatgtaggg     5280

aactcatcac agtgttgtta cttgggcccc aatgttccta gcctattttc tgtctactat     5340

tcagagtctt gctgtgtttt aatataatat ccaggatttt tatatgcatt tagcagaagg     5400

atgtctactc tgcctttgta gaagtgtctc actgattttt acatattttt ccagcacaca     5460

aacatacaca atttaactca aagcatctta gcagagctta attaaatgga tagatgtctg     5520

ttccctttgc tggacgccaa gaatacaaaa aagaacaagt gacaattttc tctgtcttag     5580

ggagaagaga cagcagaagt gtaaatgatc cctaaagagt gatagatgtt atcatgaagc     5640

cacaggaggg gtgccaggct gcacaaaaga gacactggat gcttcttggt agtagaggca     5700

gtggcttccc agccttgggg ctaaggcttg tagggtgaat tggaactttt cagatgagca     5760

aggcaaagaa gggaccttct aacattcctt ggatggaaca tttttgacat tttcccattt     5820

acagctactt atattttcta caagtgtcac tgtgaccaac ttatgtacac atactttttc     5880

ttgcttagtt ataataatct gttcttaaag aaaatgtcag tctctacatt ctatgctgac     5940

tgttaaggaa agagcaccca catctgctcc tacttagctt tttttctgtg gttcttacac     6000

agtattcctt tttttctttt cttgaaagag actcctcctt tcttttcttt tcttgaaaga     6060

gttttaaaca gataagatgg caaaagtgac tgatctctac tcccccagtt tgaatggtaa     6120

atttgaatgg taaattccca tgaacatata tggaaatgtc tttatcctac tttctccaat     6180

aaaggctgtt cttagctttt caaatgcaaa gtgaaacctt tatttatctt gatttctttt     6240

tttttttttt tttttttttt ttttttgaga tgctctgtca cccaggctgg agtgcagtgg     6300

caagatcttg gctcactgca agctccgcct cccaggttca cgccattctc ctggctcagc     6360

ctcccgagta actgggacta caggcacctg ccgtcacgcc tggctaattt tttgtatttt     6420

tagtagagaa tggagtttca ccgtgttagc caggatggtc tcgatctcct gaccttgtga     6480

tctgcccgcc tcggcctccc aaagtgctgg gattacaggc tcgagccact gcctccagcc     6540

tatcctgatt tctactgtca tgcctcacat cagtcctttt tttttttttt gagacagagt     6600

ctcgctctgt ggcccaggct agactgcagt ggcatgatct cggctcactg caacctccac     6660

ctccggggtt ctagcaattc tcctgcctca gcctcctgag tagctgggat tataggcgca     6720

tgccacacct ggctttttgt attttagtgg agatggggtt tcactgtgtt gctcaggctg     6780

gtcttgatct cctgagctca gacaatcccc ccgccttggc ctcccaaagt gctaggatta     6840

taggcgagag ctgctgtgtg cttcttaagt gaggtaagta acttccatag aaaatttcca     6900

tcagttcatt catgaaagaa caaagaacct ggcaaaactt aaaaaaacgt ttccaagaat     6960

cagataaaag aggacaaacc ttagggagaa gaaggcagct gctcatttcc agcaggggaa     7020

gtagctgcat agagtacaag gactggtagg cctgttggct gttcctgttt aaggagacaa     7080

gatgggcatg gaacagggac caccccctcc tctgggagaa gctgttaccc ccttcacttt     7140

tcctcctctg tcattaccca caatcactct ccttctttgc gctatggtag gtgtttaccc     7200

atcataggaa tgggcatttg aactttgaaa ctgaatgtgg tgattacact tcatgctgaa     7260

gcttttcaca tgagtgcttt cataagcatt aagtaaaatt ttataatgac tgcagtccaa     7320

ggacattttc cctggttttt ggccagtcta aatattgtaa gagagagaga agaaaagtgt     7380

acggaatata attgtctcta agctaagaaa tgtggatgtt caaataaaac atacgtacag     7440

aa                                                                    7442


<210>  466
<211>  925
<212>  PRT
<213>  Homo Sapiens

<400>  466

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  467
<211>  5820
<212>  DNA
<213>  Homo Sapiens

<400>  467
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag gatccctgct gggcaccaac agctccacca      180

tggggctggc ctggggacta ggcgtcctgt tcctgatgca tgtgtgtggc accaaccgca      240

ttccagagtc tggcggagac aacagcgtgt ttgacatctt tgaactcacc ggggccgccc      300

gcaaggggtc tgggcgccga ctggtgaagg gccccgaccc ttccagccca gctttccgca      360

tcgaggatgc caacctgatc ccccctgtgc ctgatgacaa gttccaagac ctggtggatg      420

ctgtgcgggc agaaaagggt ttcctccttc tggcatccct gaggcagatg aagaagaccc      480

ggggcacgct gctggccctg gagcggaaag accactctgg ccaggtcttc agcgtggtgt      540

ccaatggcaa ggcgggcacc ctggacctca gcctgaccgt ccaaggaaag cagcacgtgg      600

tgtctgtgga agaagctctc ctggcaaccg gccagtggaa gagcatcacc ctgtttgtgc      660

aggaagacag ggcccagctg tacatcgact gtgaaaagat ggagaatgct gagttggacg      720

tccccatcca aagcgtcttc accagagacc tggccagcat cgccagactc cgcatcgcaa      780

aggggggcgt caatgacaat ttccaggggg tgctgcagaa tgtgaggttt gtctttggaa      840

ccacaccaga agacatcctc aggaacaaag gctgctccag ctctaccagt gtcctcctca      900

cccttgacaa caacgtggtg aatggttcca gccctgccat ccgcactaac tacattggcc      960

acaagacaaa ggacttgcaa gccatctgcg gcatctcctg tgatgagctg tccagcatgg     1020

tcctggaact caggggcctg cgcaccattg tgaccacgct gcaggacagc atccgcaaag     1080

tgactgaaga gaacaaagag ttggccaatg agctgaggcg gcctccccta tgctatcaca     1140

acggagttca gtacagaaat aacgaggaat ggactgttga tagctgcact gagtgtcact     1200

gtcagaactc agttaccatc tgcaaaaagg tgtcctgccc catcatgccc tgctccaatg     1260

ccacagttcc tgatggagaa tgctgtcctc gctgttggcc cagcgactct gcggacgatg     1320

gctggtctcc atggtccgag tggacctcct gttctacgag ctgtggcaat ggaattcagc     1380

agcgcggccg ctcctgcgat agcctcaaca accgatgtga gggctcctcg gtccagacac     1440

ggacctgcca cattcaggag tgtgacaaga gatttaaaca ggatggtggc tggagccact     1500

ggtccccgtg gtcatcttgt tctgtgacat gtggtgatgg tgtgatcaca aggatccggc     1560

tctgcaactc tcccagcccc cagatgaacg ggaaaccctg tgaaggcgaa gcgcgggaga     1620

ccaaagcctg caagaaagac gcctgcccca tcaatggagg ctggggtcct tggtcaccat     1680

gggacatctg ttctgtcacc tgtggaggag gggtacagaa acgtagtcgt ctctgcaaca     1740

accccacacc ccagtttgga ggcaaggact gcgttggtga tgtaacagaa aaccagatct     1800

gcaacaagca ggactgtcca attgatggat gcctgtccaa tccctgcttt gccggcgtga     1860

agtgtactag ctaccctgat ggcagctgga aatgtggtgc ttgtccccct ggttacagtg     1920

gaaatggcat ccagtgcaca gatgttgatg agtgcaaaga agtgcctgat gcctgcttca     1980

accacaatgg agagcaccgg tgtgagaaca cggaccccgg ctacaactgc ctgccctgcc     2040

ccccacgctt caccggctca cagcccttcg gccagggtgt cgaacatgcc acggccaaca     2100

aacaggtgtg caagccccgt aacccctgca cggatgggac ccacgactgc aacaagaacg     2160

ccaagtgcaa ctacctgggc cactatagcg accccatgta ccgctgcgag tgcaagcctg     2220

gctacgctgg caatggcatc atctgcgggg aggacacaga cctggatggc tggcccaatg     2280

agaacctggt gtgcgtggcc aatgcgactt accactgcaa aaaggataat tgccccaacc     2340

ttcccaactc agggcaggaa gactatgaca aggatggaat tggtgatgcc tgtgatgatg     2400

acgatgacaa tgataaaatt ccagatgaca gggacaactg tccattccat tacaacccag     2460

ctcagtatga ctatgacaga gatgatgtgg gagaccgctg tgacaactgt ccctacaacc     2520

acaacccaga tcaggcagac acagacaaca atggggaagg agacgcctgt gctgcagaca     2580

ttgatggaga cggtatcctc aatgaacggg acaactgcca gtacgtctac aatgtggacc     2640

agagagacac tgatatggat ggggttggag atcagtgtga caattgcccc ttggaacaca     2700

atccggatca gctggactct gactcagacc gcattggaga tacctgtgac aacaatcagg     2760

atattgatga agatggccac cagaacaatc tggacaactg tccctatgtg cccaatgcca     2820

accaggctga ccatgacaaa gatggcaagg gagatgcctg tgaccacgat gatgacaacg     2880

atggcattcc tgatgacaag gacaactgca gactcgtgcc caatcccgac cagaaggact     2940

ctgacggcga tggtcgaggt gatgcctgca aagatgattt tgaccatgac agtgtgccag     3000

acatcgatga catctgtcct gagaatgttg acatcagtga gaccgatttc cgccgattcc     3060

agatgattcc tctggacccc aaagggacat cccaaaatga ccctaactgg gttgtacgcc     3120

atcagggtaa agaactcgtc cagactgtca actgtgatcc tggactcgct gtaggttatg     3180

atgagtttaa tgctgtggac ttcagtggca ccttcttcat caacaccgaa agggacgatg     3240

actatgctgg atttgtcttt ggctaccagt ccagcagccg cttttatgtt gtgatgtgga     3300

agcaagtcac ccagtcctac tgggacacca accccacgag ggctcaggga tactcgggcc     3360

tttctgtgaa agttgtaaac tccaccacag ggcctggcga gcacctgcgg aacgccctgt     3420

ggcacacagg aaacacccct ggccaggtgc gcaccctgtg gcatgaccct cgtcacatag     3480

gctggaaaga tttcaccgcc tacagatggc gtctcagcca caggccaaag acgggtttca     3540

ttagagtggt gatgtatgaa gggaagaaaa tcatggctga ctcaggaccc atctatgata     3600

aaacctatgc tggtggtaga ctagggttgt ttgtcttctc tcaagaaatg gtgttcttct     3660

ctgacctgaa atacgaatgt agagatccct aatcatcaaa ttgttgattg aaagactgat     3720

cataaaccaa tgctggtatt gcaccttctg gaactatggg cttgagaaaa cccccaggat     3780

cacttctcct tggcttcctt cttttctgtg cttgcatcag tgtggactcc tagaacgtgc     3840

gacctgcctc aagaaaatgc agttttcaaa aacagactca gcattcagcc tccaatgaat     3900

aagacatctt ccaagcatat aaacaattgc tttggtttcc ttttgaaaaa gcatctactt     3960

gcttcagttg ggaaggtgcc cattccactc tgcctttgtc acagagcagg gtgctattgt     4020

gaggccatct ctgagcagtg gactcaaaag cattttcagg catgtcagag aagggaggac     4080

tcactagaat tagcaaacaa aaccaccctg acatcctcct tcaggaacac ggggagcaga     4140

ggccaaagca ctaaggggag ggcgcatacc cgagacgatt gtatgaagaa aatatggagg     4200

aactgttaca tgttcggtac taagtcattt tcaggggatt gaaagactat tgctggattt     4260

catgatgctg actggcgtta gctgattaac ccatgtaaat aggcacttaa atagaagcag     4320

gaaagggaga caaagactgg cttctggact tcctccctga tccccaccct tactcatcac     4380

ctgcagtggc cagaattagg gaatcagaat caaaccagtg taaggcagtg ctggctgcca     4440

ttgcctggtc acattgaaat tggtggcttc attctagatg tagcttgtgc agatgtagca     4500

ggaaaatagg aaaacctacc atctcagtga gcaccagctg cctcccaaag gaggggcagc     4560

cgtgcttata tttttatggt tacaatggca caaaattatt atcaacctaa ctaaaacatt     4620

ccttttctct tttttcctga attatcatgg agttttctaa ttctctcttt tggaatgtag     4680

atttttttta aatgctttac gatgtaaaat atttattttt tacttattct ggaagatctg     4740

gctgaaggat tattcatgga acaggaagaa gcgtaaagac tatccatgtc atctttgttg     4800

agagtcttcg tgactgtaag attgtaaata cagattattt attaactctg ttctgcctgg     4860

aaatttaggc ttcatacgga aagtgtttga gagcaagtag ttgacattta tcagcaaatc     4920

tcttgcaaga acagcacaag gaaaatcagt ctaataagct gctctgcccc ttgtgctcag     4980

agtggatgtt atgggattct ttttttctct gttttatctt ttcaagtgga attagttggt     5040

tatccatttg caaatgtttt aaattgcaaa gaaagccatg aggtcttcaa tactgtttta     5100

ccccatccct tgtgcatatt tccagggaga aggaaagcat atacactttt ttctttcatt     5160

tttccaaaag agaaaaaaat gacaaaaggt gaaacttaca tacaaatatt acctcatttg     5220

ttgtgtgact gagtaaagaa tttttggatc aagcggaaag agtttaagtg tctaacaaac     5280

ttaaagctac tgtagtacct aaaaagtcag tgttgtacat agcataaaaa ctctgcagag     5340

aagtattccc aataaggaaa tagcattgaa atgttaaata caatttctga aagttatgtt     5400

ttttttctat catctggtat accattgctt tatttttata aattattttc tcattgccat     5460

tggaatagat atctcagatt gtgtagatat gctatttaaa taatttatca ggaaatactg     5520

cctgtagagt tagtatttct atttttatat aatgtttgca cactgaattg aagaattgtt     5580

ggttttttct tttttttgtt ttgttttttt tttttttttt ttttgctttt gacctcccat     5640

ttttactatt tgccaatacc tttttctagg aatgtgcttt tttttgtaca catttttatc     5700

cattttacat tctaaagcag tgtaagttgt atattactgt ttcttatgta caaggaacaa     5760

caataaatca tatggaaatt tatatttata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5820


<210>  468
<211>  1170
<212>  PRT
<213>  Homo Sapiens

<400>  468

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  469
<211>  4711
<212>  DNA
<213>  Homo Sapiens

<400>  469
caggctgcgg acccagttgc gagaggccta ttatctgctg atccaggcca tgcacgacct       60

gccccctgac tcgggcgcgc ggcggggcgg caggggcttg gcggatcaca gcttccccgc      120

gggagcccgg gctccgggcc agccgccttc ccgcggcgcc gcgtaccgcc gagcctgccc      180

ccgggacggg gagcggggag gcggcggacg ccctcggcag caggtgtccc cgccccggtc      240

gcctcagagg gagccgcggg gaggccagct gcggactcct cggatgcggc cgtcctgcag      300

cagaagcctc gagagcctcc gggtgggtgc caagccgcct cccttccagc ggtggccgag      360

cgacagctgg atcaggtgcg gcgcgcaccg ggactgggac gagcccccgc cacgtggagg      420

caggatggac ggctggagtg gggaccgcgc ccgggcggct gcacccaccg gcctccagcc      480

tccaggctgc aaggaccacg gctgctcctc gggaagccct ttcagggatc cagcggggtc      540

ctctgtgata cgcagtggca aaggagaccg ccaggaaggc ccctccttcc tcaggccgcc      600

ggcagtgaca gtcaagaagc tgcagaagtg gatgtacaaa gggcgtctgc tgtccctggg      660

aatgaagggt cgtgcccgtg ggacggctcc caaagtcaca ggaacgcagg cagcctcccc      720

aaatgtgggc gctttgaaag tgcgtgaaaa ccgtgtcctg tcggtgcctc cagaccaaag      780

aattacgctg acagatttat ttgaaaatgc ctatgggtct tcaatgaagg gaagagaact      840

tgaagagctg aaggataata ttgaattcag aggtcataag ccacttaaca gcatcactgt      900

ttcaaagaaa cgcaattggc tatatcagag tactctgagg cctcttaatc tggaagaaga      960

aaataagaaa tgccaagata gaagtcattt atccatctca cctgtgtctc tacctaaaca     1020

tcagctatca cagtctttcc tcaaatcatc taaagagtac tgtacatatg tggtatgtaa     1080

cgctacaaac tcttcattat cgaaaaactg tgctttagat tttaatgagg aaaatgatgc     1140

agatgatgaa ggagaaatat ggtacaatcc cattcctgag gatgatgacc ttggtatatc     1200

aagtgccttg agttttggtg aggccgactc tgctgttctg aagctccctg ctgtcaattt     1260

gagcatgttg tctggcagtg acctgatgaa agcagagcgg catactgaag actcactgtg     1320

ctcttccgaa catgcaggtg atattcagac cacacggtca aatggaatga atcctataca     1380

tcctgcccat tccacagaat ttgtgcagca gtacaagcaa aagctaggac acaagacaca     1440

agaaggtata atggtggagg acagtcccat gttgaaatct ccttttgcag gttctgggat     1500

cctggctgct acaaatagta ctgaattggg aattatggaa ccatcttctc caaatcctag     1560

ccctgtgaaa aaaggcagtt caattaattg gtcattgcca gataaaataa aatctccacg     1620

aactgtgagg aaactttcca tgaaaatgaa aaagttgcca gaatttagcc gaaagctaag     1680

cgttaaggga acattgaatt atataaacag tccagataat actccttctt tgtctaaata     1740

taactgccga gaagttcatc atactgatat tctgccctct gggaacacaa ccaccgctgc     1800

taagaggaat gttataagcc gataccatct tgataccagt gtatcctccc agcagagcta     1860

ccagaagaaa aactctatga gttctaagta ttcctgcaaa ggtggttacc ttagtgatgg     1920

agactcacct gaacttacaa ctaaagctag caaacatgga tctgaaaaca aatttggaaa     1980

aggaaaagaa ataatttcaa atagttgtag caagaatgaa atagacattg atgcttttag     2040

gcattatagc ttttctgatc aacctaagtg ttcacagtac atatctgggc tcatgagtgt     2100

acatttctat ggtgctgagg atttaaaacc acctcggata gattcaaaag acgtcttttg     2160

tgcaattcag gtagattcag taaacaaagc aagaacagct ttgctcacat gccgaacaac     2220

atttttagac atggatcaca ctttcaacat agaaattgaa aatgcacaac atttgaaact     2280

agtagtattc agttgggaac ccactccaag aaaaaatcga gtttgttgtc atggaactgt     2340

tgttcttccc accttattta gagtgacaaa gactcatcag ttggctgtca aacttgaacc     2400

tagaggtctt atttatgtga aagtgactct tatggaacag tgggagaatt ctcttcatgg     2460

actagatata aaccaagaac caataatatt tggagttgat attcaaaaag ttgtagagaa     2520

agaaaatata ggactgatgg tgccccttct gatacagaaa tgtattatgg aaattgaaaa     2580

gagaggctgt caggtagtag gcctgtatcg attatgtggt tcggcagcag tcaagaaaga     2640

actgcgagag gcttttgaga gagatagcaa agctgttggt ctgtgtgaaa accagtaccc     2700

agatataaat gtaataacag gtgttcttaa ggattattta agagaactcc cttctcctct     2760

gataacaaag cagctttatg aggctgtatt agatgcaatg gcaaaaagtc ctttgaaaat     2820

gtcatcaaat ggttgtgaga atgacccagg tgactctaag tacactgttg acctgctgga     2880

ttgtctgcca gagattgaga aggcaaccct aaagatgttg ttggatcatt tgaaattggt     2940

ggcttcctat catgaagtga ataagatgac gtgccagaat ttggctgtgt gctttggacc     3000

agtattatta agtcagaggc aagagccttc cacccataac aacagagtct ttactgattc     3060

agaagaactt gcaagtgctt tggattttaa aaaacacatt gaagttcttc attacttact     3120

ccaactctgg ccagtgcagc gtttaactgt caaaaaatca acagacaatt tattcccaga     3180

gcagaagtct tctctgaatt atctgaggca gaagaaagaa cgacctcata tgttaaattt     3240

gagtggtact gattcatcag gagtacttag gccaaggcaa aaccgattag acagtccact     3300

tagcaatcgt tatgcaggag actggagcag ctgtggggaa aactactttt taaatacaaa     3360

agaaaattta aatgatgtgg attatgatga tgtcccttca gaagatagaa aaatcggaga     3420

aaattatagc aaaatggatg ggccagaagt aatgattgaa cagccaattc ccatgtccaa     3480

agagtgtaca tttcagacat atttgacaat gcagacagtt gagtctacag tggatcgaaa     3540

aaacaatctc aaagatctac aagaaagtat tgatactttg attggaaatc tggaacgtga     3600

gctcaacaaa aacaagctta atatgagttt ttgagattga gggttttttt ttgtaatgtc     3660

ttaaagtttc aaatctgttt ttgttttatt ttcttatacc acccacagcg atgttttcat     3720

ttttttactc ttgaaatctt taattaattt ttaataagtt tatctgattc aattaaaaac     3780

actattcatt aatacaattt ttacttatct cactagaaaa cttttctggg gatcaataaa     3840

acttggactt cttgggatat tttactaaat cttgccaact ctatggagat aactttcaaa     3900

tgcacttaag aaggttcaca taagttatta gcccctcaag gtttttctgc tttatgggaa     3960

ccactcttct gtagctgaga cagatgtcct tttttttgtt gttttttgag acagagtctc     4020

actctgtcgc ccaggctgga gtgcactggt gcgatctcag gtcactgcaa cctccacctc     4080

cctggttcaa gtgattctcc tgccacagcc tcccgagtag ctgtgatgac ggggcccacc     4140

accatgccca gctaattatt gtatttttag taaagatggg gtttcaccat gttggccagg     4200

ctggtctcga actcctgatc tcagatgatc cgcccacctt ggcctcccaa agtgctggga     4260

ttacaggcgt gagccactgc gcctggcctc tagatgttct tttagaggaa catcacagct     4320

gctcagtctg atttgcagta ctggtcctgg tacactgcaa catcctttgg tcaaatttta     4380

tttgtaatgc aaatgctgct ataagaaaat ctttttataa ataaaagtga aattatacaa     4440

gtattaatgt tttctgtatt aacagtaatt atttaagctt ataaaaatta aatattttta     4500

taatcctgaa actgtatata tttataaatg catatatgta tagatatcag gatgggggag     4560

gggttattgt agaatcacat gtatttttaa agtatatatg tcatgaggcc aaaattatta     4620

tcttaaagta tttttttcag ggaaagaaca tttaaattaa aggaggaatt acataaaaac     4680

acttgaacaa taatactcta gaagcatctg a                                    4711


<210>  470
<211>  1194
<212>  PRT
<213>  Homo Sapiens

<400>  470

Met His Asp Leu Pro Pro Asp Ser Gly Ala Arg Arg Gly Gly Arg Gly 
1               5                   10                  15      


Leu Ala Asp His Ser Phe Pro Ala Gly Ala Arg Ala Pro Gly Gln Pro 
            20                  25                  30          


Pro Ser Arg Gly Ala Ala Tyr Arg Arg Ala Cys Pro Arg Asp Gly Glu 
        35                  40                  45              


Arg Gly Gly Gly Gly Arg Pro Arg Gln Gln Val Ser Pro Pro Arg Ser 
    50                  55                  60                  


Pro Gln Arg Glu Pro Arg Gly Gly Gln Leu Arg Thr Pro Arg Met Arg 
65                  70                  75                  80  


Pro Ser Cys Ser Arg Ser Leu Glu Ser Leu Arg Val Gly Ala Lys Pro 
                85                  90                  95      


Pro Pro Phe Gln Arg Trp Pro Ser Asp Ser Trp Ile Arg Cys Gly Ala 
            100                 105                 110         


His Arg Asp Trp Asp Glu Pro Pro Pro Arg Gly Gly Arg Met Asp Gly 
        115                 120                 125             


Trp Ser Gly Asp Arg Ala Arg Ala Ala Ala Pro Thr Gly Leu Gln Pro 
    130                 135                 140                 


Pro Gly Cys Lys Asp His Gly Cys Ser Ser Gly Ser Pro Phe Arg Asp 
145                 150                 155                 160 


Pro Ala Gly Ser Ser Val Ile Arg Ser Gly Lys Gly Asp Arg Gln Glu 
                165                 170                 175     


Gly Pro Ser Phe Leu Arg Pro Pro Ala Val Thr Val Lys Lys Leu Gln 
            180                 185                 190         


Lys Trp Met Tyr Lys Gly Arg Leu Leu Ser Leu Gly Met Lys Gly Arg 
        195                 200                 205             


Ala Arg Gly Thr Ala Pro Lys Val Thr Gly Thr Gln Ala Ala Ser Pro 
    210                 215                 220                 


Asn Val Gly Ala Leu Lys Val Arg Glu Asn Arg Val Leu Ser Val Pro 
225                 230                 235                 240 


Pro Asp Gln Arg Ile Thr Leu Thr Asp Leu Phe Glu Asn Ala Tyr Gly 
                245                 250                 255     


Ser Ser Met Lys Gly Arg Glu Leu Glu Glu Leu Lys Asp Asn Ile Glu 
            260                 265                 270         


Phe Arg Gly His Lys Pro Leu Asn Ser Ile Thr Val Ser Lys Lys Arg 
        275                 280                 285             


Asn Trp Leu Tyr Gln Ser Thr Leu Arg Pro Leu Asn Leu Glu Glu Glu 
    290                 295                 300                 


Asn Lys Lys Cys Gln Asp Arg Ser His Leu Ser Ile Ser Pro Val Ser 
305                 310                 315                 320 


Leu Pro Lys His Gln Leu Ser Gln Ser Phe Leu Lys Ser Ser Lys Glu 
                325                 330                 335     


Tyr Cys Thr Tyr Val Val Cys Asn Ala Thr Asn Ser Ser Leu Ser Lys 
            340                 345                 350         


Asn Cys Ala Leu Asp Phe Asn Glu Glu Asn Asp Ala Asp Asp Glu Gly 
        355                 360                 365             


Glu Ile Trp Tyr Asn Pro Ile Pro Glu Asp Asp Asp Leu Gly Ile Ser 
    370                 375                 380                 


Ser Ala Leu Ser Phe Gly Glu Ala Asp Ser Ala Val Leu Lys Leu Pro 
385                 390                 395                 400 


Ala Val Asn Leu Ser Met Leu Ser Gly Ser Asp Leu Met Lys Ala Glu 
                405                 410                 415     


Arg His Thr Glu Asp Ser Leu Cys Ser Ser Glu His Ala Gly Asp Ile 
            420                 425                 430         


Gln Thr Thr Arg Ser Asn Gly Met Asn Pro Ile His Pro Ala His Ser 
        435                 440                 445             


Thr Glu Phe Val Gln Gln Tyr Lys Gln Lys Leu Gly His Lys Thr Gln 
    450                 455                 460                 


Glu Gly Ile Met Val Glu Asp Ser Pro Met Leu Lys Ser Pro Phe Ala 
465                 470                 475                 480 


Gly Ser Gly Ile Leu Ala Ala Thr Asn Ser Thr Glu Leu Gly Ile Met 
                485                 490                 495     


Glu Pro Ser Ser Pro Asn Pro Ser Pro Val Lys Lys Gly Ser Ser Ile 
            500                 505                 510         


Asn Trp Ser Leu Pro Asp Lys Ile Lys Ser Pro Arg Thr Val Arg Lys 
        515                 520                 525             


Leu Ser Met Lys Met Lys Lys Leu Pro Glu Phe Ser Arg Lys Leu Ser 
    530                 535                 540                 


Val Lys Gly Thr Leu Asn Tyr Ile Asn Ser Pro Asp Asn Thr Pro Ser 
545                 550                 555                 560 


Leu Ser Lys Tyr Asn Cys Arg Glu Val His His Thr Asp Ile Leu Pro 
                565                 570                 575     


Ser Gly Asn Thr Thr Thr Ala Ala Lys Arg Asn Val Ile Ser Arg Tyr 
            580                 585                 590         


His Leu Asp Thr Ser Val Ser Ser Gln Gln Ser Tyr Gln Lys Lys Asn 
        595                 600                 605             


Ser Met Ser Ser Lys Tyr Ser Cys Lys Gly Gly Tyr Leu Ser Asp Gly 
    610                 615                 620                 


Asp Ser Pro Glu Leu Thr Thr Lys Ala Ser Lys His Gly Ser Glu Asn 
625                 630                 635                 640 


Lys Phe Gly Lys Gly Lys Glu Ile Ile Ser Asn Ser Cys Ser Lys Asn 
                645                 650                 655     


Glu Ile Asp Ile Asp Ala Phe Arg His Tyr Ser Phe Ser Asp Gln Pro 
            660                 665                 670         


Lys Cys Ser Gln Tyr Ile Ser Gly Leu Met Ser Val His Phe Tyr Gly 
        675                 680                 685             


Ala Glu Asp Leu Lys Pro Pro Arg Ile Asp Ser Lys Asp Val Phe Cys 
    690                 695                 700                 


Ala Ile Gln Val Asp Ser Val Asn Lys Ala Arg Thr Ala Leu Leu Thr 
705                 710                 715                 720 


Cys Arg Thr Thr Phe Leu Asp Met Asp His Thr Phe Asn Ile Glu Ile 
                725                 730                 735     


Glu Asn Ala Gln His Leu Lys Leu Val Val Phe Ser Trp Glu Pro Thr 
            740                 745                 750         


Pro Arg Lys Asn Arg Val Cys Cys His Gly Thr Val Val Leu Pro Thr 
        755                 760                 765             


Leu Phe Arg Val Thr Lys Thr His Gln Leu Ala Val Lys Leu Glu Pro 
    770                 775                 780                 


Arg Gly Leu Ile Tyr Val Lys Val Thr Leu Met Glu Gln Trp Glu Asn 
785                 790                 795                 800 


Ser Leu His Gly Leu Asp Ile Asn Gln Glu Pro Ile Ile Phe Gly Val 
                805                 810                 815     


Asp Ile Gln Lys Val Val Glu Lys Glu Asn Ile Gly Leu Met Val Pro 
            820                 825                 830         


Leu Leu Ile Gln Lys Cys Ile Met Glu Ile Glu Lys Arg Gly Cys Gln 
        835                 840                 845             


Val Val Gly Leu Tyr Arg Leu Cys Gly Ser Ala Ala Val Lys Lys Glu 
    850                 855                 860                 


Leu Arg Glu Ala Phe Glu Arg Asp Ser Lys Ala Val Gly Leu Cys Glu 
865                 870                 875                 880 


Asn Gln Tyr Pro Asp Ile Asn Val Ile Thr Gly Val Leu Lys Asp Tyr 
                885                 890                 895     


Leu Arg Glu Leu Pro Ser Pro Leu Ile Thr Lys Gln Leu Tyr Glu Ala 
            900                 905                 910         


Val Leu Asp Ala Met Ala Lys Ser Pro Leu Lys Met Ser Ser Asn Gly 
        915                 920                 925             


Cys Glu Asn Asp Pro Gly Asp Ser Lys Tyr Thr Val Asp Leu Leu Asp 
    930                 935                 940                 


Cys Leu Pro Glu Ile Glu Lys Ala Thr Leu Lys Met Leu Leu Asp His 
945                 950                 955                 960 


Leu Lys Leu Val Ala Ser Tyr His Glu Val Asn Lys Met Thr Cys Gln 
                965                 970                 975     


Asn Leu Ala Val Cys Phe Gly Pro Val Leu Leu Ser Gln Arg Gln Glu 
            980                 985                 990         


Pro Ser Thr His Asn Asn Arg Val  Phe Thr Asp Ser Glu  Glu Leu Ala 
        995                 1000                 1005             


Ser Ala  Leu Asp Phe Lys Lys  His Ile Glu Val Leu  His Tyr Leu 
    1010                 1015                 1020             


Leu Gln  Leu Trp Pro Val Gln  Arg Leu Thr Val Lys  Lys Ser Thr 
    1025                 1030                 1035             


Asp Asn  Leu Phe Pro Glu Gln  Lys Ser Ser Leu Asn  Tyr Leu Arg 
    1040                 1045                 1050             


Gln Lys  Lys Glu Arg Pro His  Met Leu Asn Leu Ser  Gly Thr Asp 
    1055                 1060                 1065             


Ser Ser  Gly Val Leu Arg Pro  Arg Gln Asn Arg Leu  Asp Ser Pro 
    1070                 1075                 1080             


Leu Ser  Asn Arg Tyr Ala Gly  Asp Trp Ser Ser Cys  Gly Glu Asn 
    1085                 1090                 1095             


Tyr Phe  Leu Asn Thr Lys Glu  Asn Leu Asn Asp Val  Asp Tyr Asp 
    1100                 1105                 1110             


Asp Val  Pro Ser Glu Asp Arg  Lys Ile Gly Glu Asn  Tyr Ser Lys 
    1115                 1120                 1125             


Met Asp  Gly Pro Glu Val Met  Ile Glu Gln Pro Ile  Pro Met Ser 
    1130                 1135                 1140             


Lys Glu  Cys Thr Phe Gln Thr  Tyr Leu Thr Met Gln  Thr Val Glu 
    1145                 1150                 1155             


Ser Thr  Val Asp Arg Lys Asn  Asn Leu Lys Asp Leu  Gln Glu Ser 
    1160                 1165                 1170             


Ile Asp  Thr Leu Ile Gly Asn  Leu Glu Arg Glu Leu  Asn Lys Asn 
    1175                 1180                 1185             


Lys Leu  Asn Met Ser Phe 
    1190                 


<210>  471
<211>  3557
<212>  DNA
<213>  Homo Sapiens

<400>  471
agcatttgtc actcaacctc tgaatgttag tgacactatt gggacgaaaa aggactgtgc       60

tggcccaaat ggcaggcatc tcatatgtgg catctttctt tctccttctg actaagctca      120

gcattggcca gagagaagta acagttcaga aaggaccact gtttagagct gaaggttacc      180

cagtcagcat tggctgcaat gtaactggcc accagggacc ttctgagcag catttccagt      240

ggtctgttta cctgccgaca aacccgaccc aggaagtcca gatcattagc accaaggatg      300

ctgccttctc ttacgcagta tatacgcagc gggtgcgaag cggagacgtc tacgtggaga      360

gggtccaggg caactcagtc ttgttgcaca tctcaaaact ccagatgaag gatgctggcg      420

agtatgagtg tcacacacca aacactgatg agaaatacta tggaagttac agtgcaaaga      480

ctaatctaat tgttattcca gataccctct ctgccaccat gagttctcag actctcggta      540

aggaggaagg tgagccatta gccctcacct gtgaggcatc caaagccaca gcccaacata      600

ctcacctctc tgtcacctgg tacctaacac aggatggagg aggaagccaa gccactgaga      660

ttatttctct ctccaaagat tttatattgg tccctgggcc cttgtataca gagcggtttg      720

cagccagtga cgtacagctc aacaaactgg gacccactac attcaggctg tccatagaga      780

ggctccagtc ctcagatcag ggtcagctgt tctgtgaggc aacggaatgg attcaggatc      840

cagatgaaac ttggatgttc atcaccaaaa agcagaccga tcaaaccact ctgaggatcc      900

agccagcagt gaaagatttt caagtcaaca ttacagctga cagcttgttt gctgaaggga      960

aacccttaga actggtttgc ctggttgtaa gcagtggccg tgacccacag cttcaaggca     1020

tttggttctt caatgggact gaaattgctc acattgatgc tggtggagtc ctgggcctga     1080

agaatgacta caaagagaga gcaagtcaag gagagctcca ggtttcaaag ttaggcccca     1140

aggctttctc tctcaagatc ttctctctgg gcccagagga tgaaggcgcc tacagatgtg     1200

tggtagcaga ggtcatgaaa acacgcacag gttcctggca ggtgcttcag agaaagcagt     1260

caccagacag ccacgtgcac ctgaggaagc cagcagcaag aagtgtggtc atgtctacca     1320

agaacaagca gcaagttgtg tgggaaggag agacactcgc ctttctctgt aaggctggtg     1380

gagctgaaag tcccctgtct gtgagctggt ggcacatccc acgggaccag acacagcccg     1440

agtttgtggc tggcatgggg caggatggca ttgtgcagct gggtgcctcc tatggggtac     1500

ccagttacca tggcaacaca aggctggaga aaatggactg ggccaccttc cagctggaga     1560

tcaccttcac tgccatcaca gacagtggca catatgagtg cagagtatct gagaagtctc     1620

ggaaccaggc cagagatctg agctggactc agaagatttc agttactgta aagtctctgg     1680

agtcaagttt acaagttagt ctgatgagcc gtcagccgca agtgatgtta accaacacct     1740

ttgacctgtc ctgtgtcgtg agggccggtt actctgacct caaggtgcca ctcactgtga     1800

cgtggcagtt ccagccagct agctctcaca tcttccacca gcttattcga atcacccaca     1860

atggcactat tgaatggggg aatttcctat cccggttcca aaagaagacg aaagtgtcgc     1920

agtctttatt tcgttcacaa ctcctagtcc atgatgccac tgaggaagag acaggagtgt     1980

atcagtgtga agtagaagtt tatgacagaa attccctata caacaaccgc cccccgaggg     2040

cttctgccat ctctcaccca ctgaggatag ccgtcacttt accagagagc aagctaaaag     2100

tgaattcaag gagtcaagtc caagagctct ccatcaactc caacactgat atagaatgta     2160

gcatcttgtc ccggtccaat ggaaaccttc agttagccat tatttggtat ttttctcctg     2220

tttccactaa tgcctcttgg ctaaagatcc tggagatgga ccaaaccaat gttataaaaa     2280

ctggggatga gtttcacacc ccacagagaa aacaaaaatt tcatactgag aaggtttccc     2340

aagacttatt tcagctgcac attctgaatg tggaagacag cgatcggggc aaatatcact     2400

gtgctgtgga ggaatggctc ctgtctacaa atggcacttg gcacaagctt ggagaaaaga     2460

agtcaggact aacagaattg aaactcaagc ccacaggaag taaggtacgt gtctccaaag     2520

tgtactggac cgaaaatgtg actgagcaca gagaagtggc catccgctgc agcctggaga     2580

gtgtaggcag ctcagccact ctgtactctg tgatgtggta ctggaacaga gaaaactctg     2640

gaagtaaatt gctggtgcac ttgcaacatg atggcttgct ggagtatggg gaagaggggc     2700

tcaggaggca cctgcactgt taccgttcat cctctacaga ctttgtcctg aagcttcatc     2760

aggtggagat ggaggatgca ggaatgtact ggtgtagggt ggcagagtgg cagctccatg     2820

gacacccaag caagtggatt aatcaagcat ccgatgagtc acagcggatg gtgctcacgg     2880

tgctgccttc agagcccacg cttccttcca ggatctgctc ctcggcccct ttactctatt     2940

tcctgttcat ctgtcccttc gtcctgctcc tccttctgct catctccctc ctctgcttat     3000

actggaaggc caggaagttg tcaacactgc gttccaacac acggaaagaa aaagctctct     3060

gggtggactt gaaagaggct ggaggtgtga ccacaaatag gagggaagac gaggaggaag     3120

atgaaggcaa ctgaatccca agaggcacct gcagccagga aggaaagctt gttttacagc     3180

ttcctgcctt gctgcctgtt tcttcccaag ccccgtgtgg aatgtggtga cctagtcacc     3240

tggaaccagc tcctgacaga ccccggcaac ttctagatga acccaagtga actttcctca     3300

ttaccatcct gaagtcacta ccccaggggg agctatagct tcatgaccgt aacatgtgac     3360

ctgtgtgctg gcaggacgac tcactgcggc tgcgccactg ggacccctcc cctacatgca     3420

ccaatgcact ctctcccctc tccatcaccc cataaaaccc tcctgtcact ttccttcaga     3480

gacaccgctt tggagagtat tcccagcgct ctccttgctt gtgacaagta aaaaaaaaaa     3540

aaaactcctt ttcatca                                                    3557


<210>  472
<211>  1021
<212>  PRT
<213>  Homo Sapiens

<400>  472

Met Ala Gly Ile Ser Tyr Val Ala Ser Phe Phe Leu Leu Leu Thr Lys 
1               5                   10                  15      


Leu Ser Ile Gly Gln Arg Glu Val Thr Val Gln Lys Gly Pro Leu Phe 
            20                  25                  30          


Arg Ala Glu Gly Tyr Pro Val Ser Ile Gly Cys Asn Val Thr Gly His 
        35                  40                  45              


Gln Gly Pro Ser Glu Gln His Phe Gln Trp Ser Val Tyr Leu Pro Thr 
    50                  55                  60                  


Asn Pro Thr Gln Glu Val Gln Ile Ile Ser Thr Lys Asp Ala Ala Phe 
65                  70                  75                  80  


Ser Tyr Ala Val Tyr Thr Gln Arg Val Arg Ser Gly Asp Val Tyr Val 
                85                  90                  95      


Glu Arg Val Gln Gly Asn Ser Val Leu Leu His Ile Ser Lys Leu Gln 
            100                 105                 110         


Met Lys Asp Ala Gly Glu Tyr Glu Cys His Thr Pro Asn Thr Asp Glu 
        115                 120                 125             


Lys Tyr Tyr Gly Ser Tyr Ser Ala Lys Thr Asn Leu Ile Val Ile Pro 
    130                 135                 140                 


Asp Thr Leu Ser Ala Thr Met Ser Ser Gln Thr Leu Gly Lys Glu Glu 
145                 150                 155                 160 


Gly Glu Pro Leu Ala Leu Thr Cys Glu Ala Ser Lys Ala Thr Ala Gln 
                165                 170                 175     


His Thr His Leu Ser Val Thr Trp Tyr Leu Thr Gln Asp Gly Gly Gly 
            180                 185                 190         


Ser Gln Ala Thr Glu Ile Ile Ser Leu Ser Lys Asp Phe Ile Leu Val 
        195                 200                 205             


Pro Gly Pro Leu Tyr Thr Glu Arg Phe Ala Ala Ser Asp Val Gln Leu 
    210                 215                 220                 


Asn Lys Leu Gly Pro Thr Thr Phe Arg Leu Ser Ile Glu Arg Leu Gln 
225                 230                 235                 240 


Ser Ser Asp Gln Gly Gln Leu Phe Cys Glu Ala Thr Glu Trp Ile Gln 
                245                 250                 255     


Asp Pro Asp Glu Thr Trp Met Phe Ile Thr Lys Lys Gln Thr Asp Gln 
            260                 265                 270         


Thr Thr Leu Arg Ile Gln Pro Ala Val Lys Asp Phe Gln Val Asn Ile 
        275                 280                 285             


Thr Ala Asp Ser Leu Phe Ala Glu Gly Lys Pro Leu Glu Leu Val Cys 
    290                 295                 300                 


Leu Val Val Ser Ser Gly Arg Asp Pro Gln Leu Gln Gly Ile Trp Phe 
305                 310                 315                 320 


Phe Asn Gly Thr Glu Ile Ala His Ile Asp Ala Gly Gly Val Leu Gly 
                325                 330                 335     


Leu Lys Asn Asp Tyr Lys Glu Arg Ala Ser Gln Gly Glu Leu Gln Val 
            340                 345                 350         


Ser Lys Leu Gly Pro Lys Ala Phe Ser Leu Lys Ile Phe Ser Leu Gly 
        355                 360                 365             


Pro Glu Asp Glu Gly Ala Tyr Arg Cys Val Val Ala Glu Val Met Lys 
    370                 375                 380                 


Thr Arg Thr Gly Ser Trp Gln Val Leu Gln Arg Lys Gln Ser Pro Asp 
385                 390                 395                 400 


Ser His Val His Leu Arg Lys Pro Ala Ala Arg Ser Val Val Met Ser 
                405                 410                 415     


Thr Lys Asn Lys Gln Gln Val Val Trp Glu Gly Glu Thr Leu Ala Phe 
            420                 425                 430         


Leu Cys Lys Ala Gly Gly Ala Glu Ser Pro Leu Ser Val Ser Trp Trp 
        435                 440                 445             


His Ile Pro Arg Asp Gln Thr Gln Pro Glu Phe Val Ala Gly Met Gly 
    450                 455                 460                 


Gln Asp Gly Ile Val Gln Leu Gly Ala Ser Tyr Gly Val Pro Ser Tyr 
465                 470                 475                 480 


His Gly Asn Thr Arg Leu Glu Lys Met Asp Trp Ala Thr Phe Gln Leu 
                485                 490                 495     


Glu Ile Thr Phe Thr Ala Ile Thr Asp Ser Gly Thr Tyr Glu Cys Arg 
            500                 505                 510         


Val Ser Glu Lys Ser Arg Asn Gln Ala Arg Asp Leu Ser Trp Thr Gln 
        515                 520                 525             


Lys Ile Ser Val Thr Val Lys Ser Leu Glu Ser Ser Leu Gln Val Ser 
    530                 535                 540                 


Leu Met Ser Arg Gln Pro Gln Val Met Leu Thr Asn Thr Phe Asp Leu 
545                 550                 555                 560 


Ser Cys Val Val Arg Ala Gly Tyr Ser Asp Leu Lys Val Pro Leu Thr 
                565                 570                 575     


Val Thr Trp Gln Phe Gln Pro Ala Ser Ser His Ile Phe His Gln Leu 
            580                 585                 590         


Ile Arg Ile Thr His Asn Gly Thr Ile Glu Trp Gly Asn Phe Leu Ser 
        595                 600                 605             


Arg Phe Gln Lys Lys Thr Lys Val Ser Gln Ser Leu Phe Arg Ser Gln 
    610                 615                 620                 


Leu Leu Val His Asp Ala Thr Glu Glu Glu Thr Gly Val Tyr Gln Cys 
625                 630                 635                 640 


Glu Val Glu Val Tyr Asp Arg Asn Ser Leu Tyr Asn Asn Arg Pro Pro 
                645                 650                 655     


Arg Ala Ser Ala Ile Ser His Pro Leu Arg Ile Ala Val Thr Leu Pro 
            660                 665                 670         


Glu Ser Lys Leu Lys Val Asn Ser Arg Ser Gln Val Gln Glu Leu Ser 
        675                 680                 685             


Ile Asn Ser Asn Thr Asp Ile Glu Cys Ser Ile Leu Ser Arg Ser Asn 
    690                 695                 700                 


Gly Asn Leu Gln Leu Ala Ile Ile Trp Tyr Phe Ser Pro Val Ser Thr 
705                 710                 715                 720 


Asn Ala Ser Trp Leu Lys Ile Leu Glu Met Asp Gln Thr Asn Val Ile 
                725                 730                 735     


Lys Thr Gly Asp Glu Phe His Thr Pro Gln Arg Lys Gln Lys Phe His 
            740                 745                 750         


Thr Glu Lys Val Ser Gln Asp Leu Phe Gln Leu His Ile Leu Asn Val 
        755                 760                 765             


Glu Asp Ser Asp Arg Gly Lys Tyr His Cys Ala Val Glu Glu Trp Leu 
    770                 775                 780                 


Leu Ser Thr Asn Gly Thr Trp His Lys Leu Gly Glu Lys Lys Ser Gly 
785                 790                 795                 800 


Leu Thr Glu Leu Lys Leu Lys Pro Thr Gly Ser Lys Val Arg Val Ser 
                805                 810                 815     


Lys Val Tyr Trp Thr Glu Asn Val Thr Glu His Arg Glu Val Ala Ile 
            820                 825                 830         


Arg Cys Ser Leu Glu Ser Val Gly Ser Ser Ala Thr Leu Tyr Ser Val 
        835                 840                 845             


Met Trp Tyr Trp Asn Arg Glu Asn Ser Gly Ser Lys Leu Leu Val His 
    850                 855                 860                 


Leu Gln His Asp Gly Leu Leu Glu Tyr Gly Glu Glu Gly Leu Arg Arg 
865                 870                 875                 880 


His Leu His Cys Tyr Arg Ser Ser Ser Thr Asp Phe Val Leu Lys Leu 
                885                 890                 895     


His Gln Val Glu Met Glu Asp Ala Gly Met Tyr Trp Cys Arg Val Ala 
            900                 905                 910         


Glu Trp Gln Leu His Gly His Pro Ser Lys Trp Ile Asn Gln Ala Ser 
        915                 920                 925             


Asp Glu Ser Gln Arg Met Val Leu Thr Val Leu Pro Ser Glu Pro Thr 
    930                 935                 940                 


Leu Pro Ser Arg Ile Cys Ser Ser Ala Pro Leu Leu Tyr Phe Leu Phe 
945                 950                 955                 960 


Ile Cys Pro Phe Val Leu Leu Leu Leu Leu Leu Ile Ser Leu Leu Cys 
                965                 970                 975     


Leu Tyr Trp Lys Ala Arg Lys Leu Ser Thr Leu Arg Ser Asn Thr Arg 
            980                 985                 990         


Lys Glu Lys Ala Leu Trp Val Asp  Leu Lys Glu Ala Gly  Gly Val Thr 
        995                 1000                 1005             


Thr Asn  Arg Arg Glu Asp Glu  Glu Glu Asp Glu Gly  Asn 
    1010                 1015                 1020     


<210>  473
<211>  478
<212>  DNA
<213>  Homo Sapiens

<400>  473
gtgtgccgga tttggttagc tgagcccacc gagaggcgcc tgcaggatga aagctctctg       60

tctcctcctc ctccctgtcc tggggctgtt ggtgtctagc aagaccctgt gctccatgga      120

agaagccatc aatgagagga tccaggaggt cgccggctcc ctaatattta gggcaataag      180

cagcattggc ctggagtgcc agagcgtcac ctccaggggg gacctggcta cttgcccccg      240

aggcttcgcc gtcaccggct gcacttgtgg ctccgcctgt ggctcgtggg atgtgcgcgc      300

cgagaccaca tgtcactgcc agtgcgcggg catggactgg accggagcgc gctgctgtcg      360

tgtgcagccc tgaggtcgcg cgcagcgcgt gcacagcgcg ggcggaggcg gctccaggtc      420

cggaggggtt gcgggggagc tggaaataaa cctggagatg atgatgatga tgatgatg        478


<210>  474
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  474

Met Lys Ala Leu Cys Leu Leu Leu Leu Pro Val Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Ser Lys Thr Leu Cys Ser Met Glu Glu Ala Ile Asn Glu Arg Ile 
            20                  25                  30          


Gln Glu Val Ala Gly Ser Leu Ile Phe Arg Ala Ile Ser Ser Ile Gly 
        35                  40                  45              


Leu Glu Cys Gln Ser Val Thr Ser Arg Gly Asp Leu Ala Thr Cys Pro 
    50                  55                  60                  


Arg Gly Phe Ala Val Thr Gly Cys Thr Cys Gly Ser Ala Cys Gly Ser 
65                  70                  75                  80  


Trp Asp Val Arg Ala Glu Thr Thr Cys His Cys Gln Cys Ala Gly Met 
                85                  90                  95      


Asp Trp Thr Gly Ala Arg Cys Cys Arg Val Gln Pro 
            100                 105             


<210>  475
<211>  5762
<212>  DNA
<213>  Homo Sapiens

<400>  475
acagaaggca gttcacctct gctcccgaca gcctgggaac ccgcaagagc cccagcattt       60

gaagtctggt cttgtgaaac cccaccctcc tctggctgtg tgattgaatg ggatgccctc      120

gaggttcacc tcacctgaga gggttttggg cagatcagca gtaaggtgtt aaattttaga      180

agcctgaaaa ctccagaaga gaaaggccaa ccaactcaaa cttgaagaca tgaaatcccc      240

aaggagaacc actttgtgcc tcatgtttat tgtgatttat tcttccaaag ctgcactgaa      300

ctggaattac gagtctacta ttcatccttt gagtcttcat gaacatgaac cagctggtga      360

agaggcactg aggcaaaaac gagccgttgc cacaaaaagt cctacggctg aagaatacac      420

tgttaatatt gagatcagtt ttgaaaatgc atccttcctg gatcctatca aagcctactt      480

gaacagcctc agttttccaa ttcatgggaa taacactgac caaattaccg acattttgag      540

cataaatgtg acaacagtct gcagacctgc tggaaatgaa atctggtgct cctgcgagac      600

aggttatggg tggcctcggg aaaggtgtct tcacaatctc atttgtcaag agcgtgacgt      660

cttcctccca gggcaccatt gcagttgcct taaagaactg cctcccaatg gacctttttg      720

cctgcttcag gaagatgtta ccctgaacat gagagtcaga ctaaatgtag gctttcaaga      780

agacctcatg aacacttcct ccgccctcta taggtcctac aagaccgact tggaaacagc      840

gttccggaag ggttacggaa ttttaccagg cttcaagggc gtgactgtga cagggttcaa      900

gtctggaagt gtggttgtga catatgaagt caagactaca ccaccatcac ttgagttaat      960

acataaagcc aatgaacaag ttgtacagag cctcaatcag acctacaaaa tggactacaa     1020

ctcctttcaa gcagttacta tcaatgaaag caatttcttt gtcacaccag aaatcatctt     1080

tgaaggggac acagtcagtc tggtgtgtga aaaggaagtt ttgtcctcca atgtgtcttg     1140

gcgctatgaa gaacagcagt tggaaatcca gaacagcagc agattctcga tttacaccgc     1200

acttttcaac aacatgactt cggtgtccaa gctcaccatc cacaacatca ctccaggtga     1260

tgcaggtgaa tatgtttgca aactgatatt agacattttt gaatatgagt gcaagaagaa     1320

aatagatgtt atgcccatcc aaattttggc aaatgaagaa atgaaggtga tgtgcgacaa     1380

caatcctgta tctttgaact gctgcagtca gggtaatgtt aattggagca aagtagaatg     1440

gaagcaggaa ggaaaaataa atattccagg aacccctgag acagacatag attctagctg     1500

cagcagatac accctcaagg ctgatggaac ccagtgccca agcgggtcgt ctggaacaac     1560

agtcatctac acttgtgagt tcatcagtgc ctatggagcc agaggcagtg caaacataaa     1620

agtgacattc atctctgtgg ccaatctaac aataaccccg gacccaattt ctgtttctga     1680

gggacaaaac ttttctataa aatgcatcag tgatgtgagt aactatgatg aggtttattg     1740

gaacacttct gctggaatta aaatatacca aagattttat accacgagga ggtatcttga     1800

tggagcagaa tcagtactga cagtcaagac ctcgaccagg gagtggaatg gaacctatca     1860

ctgcatattt agatataaga attcatacag tattgcaacc aaagacgtca ttgttcaccc     1920

gctgcctcta aagctgaaca tcatggttga tcctttggaa gctactgttt catgcagtgg     1980

ttcccatcac atcaagtgct gcatagagga ggatggagac tacaaagtta ctttccatac     2040

gggttcctca tcccttcctg ctgcaaaaga agttaacaaa aaacaagtgt gctacaaaca     2100

caatttcaat gcaagctcag tttcctggtg ttcaaaaact gttgatgtgt gttgtcactt     2160

taccaatgct gctaataatt cagtctggag cccatctatg aagctgaatc tggttcctgg     2220

ggaaaacatc acatgccagg atcccgtaat aggtgtcgga gagccgggga aagtcatcca     2280

gaagctatgc cggttctcaa acgttcccag cagccctgag agtcccattg gcgggaccat     2340

cacttacaaa tgtgtaggct cccagtggga ggagaagaga aatgactgca tctctgcccc     2400

aataaacagt ctgctccaga tggctaaggc tttgatcaag agcccctctc aggatgagat     2460

gctccctaca tacctgaagg atctttctat tagcatagac aaagcggaac atgaaatcag     2520

ctcttctcct gggagtctgg gagccattat taacatcctt gatctgctct caacagttcc     2580

aacccaagta aattcagaaa tgatgacgca cgtgctctct acggttaatg tcatccttgg     2640

caagcccgtc ttgaacacct ggaaggtttt acaacagcaa tggaccaatc agagttcaca     2700

gctactacat tcagtggaaa gattttccca agcattacag tcgggagata gccctccttt     2760

gtccttctcc caaactaatg tgcagatgag cagcatggta atcaagtcca gccacccaga     2820

aacctatcaa cagaggtttg ttttcccata ctttgacctc tggggcaatg tggtcattga     2880

caagagctat ctagaaaact tgcagtcgga ttcgtctatt gtcaccatgg ctttcccaac     2940

tctccaagcc atccttgccc aggatatcca ggaaaataac tttgcagaga gcttagtgat     3000

gacaaccact gtcagccaca atacaactat gccattcagg atttcaatga cttttaagaa     3060

caatagccct tcaggcggcg aaacgaagtg tgtcttctgg aacttcaggc ttgccaacaa     3120

cacagggggg tgggacagca gtgggtgcta tgtagaagaa ggtgatgggg acaatgtcac     3180

ctgtatctgt gaccacctaa catcattctc catcctcatg tcccctgact ccccagatcc     3240

tagttctctc ctgggaatac tcctggatat tatttcttat gttggggtgg gcttttccat     3300

cttgagcttg gcagcctgtc tagttgtgga agctgtggtg tggaaatcgg tgaccaagaa     3360

ccggacttct tatatgcgcc acacctgcat agtgaatatc gctgcctccc ttctggtcgc     3420

caacacctgg ttcattgtgg tcgctgccat ccaggacaat cgctacatac tctgcaagac     3480

agcctgtgtg gctgccacct tcttcatcca cttcttctac ctcagcgtct tcttctggat     3540

gctgacactg ggcctcatgc tgttctatcg cctggttttc attctgcatg aaacaagcag     3600

gtccactcag aaagccattg ccttctgtct tggctatggc tgcccacttg ccatctcggt     3660

catcacgctg ggagccaccc agccccggga agtctatacg aggaagaatg tctgttggct     3720

caactgggag gacaccaagg ccctgctggc tttcgccatc ccagcactga tcattgtggt     3780

ggtgaacata accatcacta ttgtggtcat caccaagatc ctgaggcctt ccattggaga     3840

caagccatgc aagcaggaga agagcagcct gtttcagatc agcaagagca ttggggtcct     3900

cacaccactc ttgggcctca cttggggttt tggtctcacc actgtgttcc cagggaccaa     3960

ccttgtgttc catatcatat ttgccatcct caatgtcttc cagggattat tcattttact     4020

ctttggatgc ctctgggatc tgaaggtaca ggaagctttg ctgaataagt tttcattgtc     4080

gagatggtct tcacagcact caaagtcaac atccctgggt tcatccacac ctgtgttttc     4140

tatgagttct ccaatatcaa ggagatttaa caatttgttt ggtaaaacag gaacgtataa     4200

tgtttccacc ccagaagcaa ccagctcatc cctggaaaac tcatccagtg cttcttcgtt     4260

gctcaactaa gaacaggata atccaaccta cgtgacctcc cggggacagt ggctgtgctt     4320

ttaaaaagag atgcttgcaa agcaatgggg aacgtgttct cggggcaggt ttccgggagc     4380

agatgccaaa aagacttttt catagagaag aggctttctt ttgtaaagac agaataaaaa     4440

taattgttat gtttctgttt gttccctccc cctccccctt gtgtgatacc acatgtgtat     4500

agtatttaag tgaaactcaa gccctcaagg cccaacttct ctgtctatat tgtaatatag     4560

aatttcgaag agacattttc actttttaca cattgggcac aaagataagc tttgattaaa     4620

gtagtaagta aaaggctacc taggaaatac ttcagtgaat tctaagaagg aaggaaggaa     4680

gaaaggaagg aaagaaggga gggaaacagg gagaaaggga aaaagaagaa aaagagaaag     4740

atgaaaatag gaacaaataa agacaaacaa cattaagggc catattgtaa gatttccatg     4800

ttaatgatct aatataatca ctcagtgcaa cattgagaat ttttttttaa tggctcaaaa     4860

atggaaactg aaagcaagtc atggggaatg aatactttgg gcagtatctt cctgatgtct     4920

tcttagctaa gaggaggaaa aaaaggctga aaaaataggg aggaaattcc ttcatcagaa     4980

cgacttcaag tggataacaa tatttataag aaatgaatgg aaggaaatat gatcctcctg     5040

agactaactt tgtatgttaa ggtttgaact aagtgaatgt atctgcagag gaagtattac     5100

aaagatatgt cattagatcc aagtgctgat taaattttta tagtttatca gaaaagcctt     5160

atattttagt ttgttccaca ttttgaaagc aaaaaatata tatttgatat acccttcaat     5220

tgccaaattt gatatgttgc actgaagaca gaccctgtca tatatttaat ggcttcaagc     5280

aggtacttct ctgtgcatta tagaatagat tttaataatc ttatagcatt gtatattatt     5340

attgctgttg tcactgttat tattattgtg gatactggcc cttggtgtgt tgcatagctc     5400

cctatgtatt ctctgtttcc atctttaagt tcccagacca atatacatta agagttttgc     5460

atggtctaaa ttgtgtttat tccaaccacg tggaaagctc ctggaaagaa attttacatt     5520

cggttgttct gtgctcctaa tgacacttga ccttgttgaa caaatggcag agcctttccc     5580

aaggatttga ttgtttgtga attatctgca tgtgtgcttt tttttggtgt gtatttcatt     5640

aaaaaatata aatatttatg aaaattgcac gcatattaga gttaaccatg tactattgat     5700

acagcaacgc tacattgcaa ataaaagtcc gatcccaaaa ggagaatgag acaaaaaaaa     5760

aa                                                                    5762


<210>  476
<211>  1346
<212>  PRT
<213>  Homo Sapiens

<400>  476

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  477
<211>  5552
<212>  DNA
<213>  Homo Sapiens

<400>  477
gagaagagca gctcaccctt cgcagccgcg atgggggaag acgacgccgc gcttcgggct       60

ggcagcaggg ggctctccga cccgtgggca gactcagtgg gagtgcgacc ccgcaccacg      120

gagcgccaca tcgccgtaca caagcggctt gtgctggcct tcgctgtgtc cctcgtggca      180

ttgctcgcgg tcacaatgct cgctgtgctg ctcagcctgc gcttcgacga gtgcggggcg      240

agtgccacgc caggcgccga cggtggcccc tcaggctttc cggagcgcgg cggcaacggg      300

agcctccctg gatcggcccg gcgcaaccac cacgcaggcg gggactcctg gcagcccgag      360

gcgggtgggg tggccagtcc ggggaccacg tcggcccagc cgccgtcgga ggaggagcgg      420

gagccgtggg agccgtggac gcagctgcgc ctgtcgggcc acctgaagcc gctgcactac      480

aatctgatgc tcaccgcctt catggagaac ttcaccttct ccggggaggt caacgtggag      540

atcgcgtgcc ggaacgccac ccgctacgta gtgctgcacg cttcccgagt ggcggtggag      600

aaagtgcagc tggccgagga ccgggcgttc ggggctgtcc ctgtagccgg ttttttcctc      660

tacccgcaaa cccaggtctt agtggtggtg ctgaatagga cactggacgc gcagaggaat      720

tacaatctga agattatcta caacgcgctc atcgagaatg agctcctggg cttcttccgc      780

agctcctatg tgctccacgg ggagagaaga ttccttggtg ttactcagtt ttcgcctaca      840

catgccagaa aggcatttcc ttgttttgat gagccaatct acaaggctac tttcaaaatc      900

agcatcaagc atcaagcaac ctatttatct ttatctaata tgccagtgga aacttccgtg      960

tttgaggaag atggatgggt tacggatcac ttttcacaga cccctctcat gtccacatat     1020

tatttagcct gggcaatttg caacttcaca tacagagaaa ctaccaccaa gagtggggtt     1080

gtagtacgat tatatgcaag acctgatgct atcagaagag gatccgggga ctatgctctc     1140

catataacaa agagattaat agaattttat gaagactact ttaaagtgcc ctattccttg     1200

ccaaaactag atcttttagc tgtgcctaag catccgtatg ctgctatgga gaactgggga     1260

ctaagtattt ttgtggaaca aagaatactg ctggatccca gtgtttcatc tatttcttat     1320

ttgctggatg tcaccatggt cattgttcat gagatatgtc accagtggtt tggtgacctt     1380

gtgacgcctg tgtggtggga agacgtgtgg ctgaaggaag ggtttgctca ctactttgaa     1440

tttgttggta cagactacct ctatcctggc tggaacatgg aaaagcagag gtttctgacc     1500

gatgttctgc atgaagtgat gctgctggac ggtttggcca gttcccatcc agtatcacag     1560

gaagtgctgc aggcaacaga tattgacagg gtgtttgact ggatcgcata taaaaagggt     1620

gctgctttaa taagaatgct ggctaatttt atgggccatt cagttttcca gaggggtttg     1680

caagattatt taaccattca taagtatggt aatgcagcca gaaatgatct ctggaataca     1740

ttatcggagg ctttaaaaag aaatgggaaa tatgtaaata tacaagaagt aatggatcag     1800

tggacactcc agatgggtta tcctgttatc accatcttgg gaaacacaac agcagaaaat     1860

agaataataa ttacccaaca gcattttatc tatgatatca gtgctaaaac taaagcactt     1920

aaacttcaga ataacagtta cctgtggcag attccattaa ctattgtggt aggaaataga     1980

agccatgtgt cttcagaagc aattatttgg gtgtctaaca aatcagagca ccacagaata     2040

acttatttgg acaaaggaag ctggctgctg gggaacatca atcaaactgg ctattttaga     2100

gtcaactatg acctaaggaa ctggagatta ttaattgatc aattaatccg gaatcatgag     2160

gttctttctg tcagtaaccg agcgggcttg atcgatgatg ccttcagcct agccagggct     2220

ggctatttgc ctcagaatat tcctctggag attatcagat acctgtctga ggagaaggat     2280

tttcttcctt ggcatgctgc cagccgagct ctttatcctc tagataaatt actggaccgc     2340

atggaaaact acaacatttt caatgaatat attttaaagc aagttgcaac aacatatatc     2400

aagcttgggt ggccgaaaaa taattttaat ggatctcttg ttcaagcatc ctaccaacat     2460

gaagaactac gtagagaagt tataatgctg gcctgcagtt ttggcaacaa gcactgtcac     2520

caacaggcat caacacttat ttcagattgg atttccagca acaggaacag aataccacta     2580

aatgttagag acatcgtata ctgtacagga gtgtcactac tggatgagga tgtctgggaa     2640

ttcatatgga tgaaattcca ttccaccaca gcagtttctg agaagaaaat attattggaa     2700

gccttaactt gcagtgatga caggaattta ttaaacaggc ttctaaatct gtcactgaat     2760

tctgaggtgg tgctggatca agatgcaatt gatgtcataa tccatgtagc tcgaaatcca     2820

catggtcgag accttgcctg gaagtttttc agggataaat ggaagatatt aaataccagg     2880

tatggagaag cattgtttat gaattccaaa ctcatcagtg gtgtcacaga atttcttaat     2940

actgaaggtg aactcaaaga gctcaagaac ttcatgaaaa actatgatgg ggtagctgct     3000

gcttctttct cacgagctgt ggaaactgtc gaagccaatg tgcgctggaa aatgctttac     3060

caagacgagc ttttccaatg gttaggaaaa gctctaagac actaatatat gtatcttata     3120

aacaaacaat tcaactcaga agtttatgag aagacacgct ttttgtggaa tgaggaaaat     3180

gtactaccta gaaaatggcc agattttcag tgttaacgtg tgggaggaat ttttttttta     3240

gtttttattt tttggttttg ggggatattt tttatttgtt tcattcattc tgttctgttt     3300

ctctactggg tgttcctctc taaagaaact cttgcaagtg aaactagcca tgattgcttc     3360

agctgtacat tccttgctgt acaggaccaa atatgatagt gatgcatgtt gatgttacag     3420

tcaatttgga aaaacatatt cagaatatct gtgcatggat atattgtcct gcctgtgttc     3480

cagcatgctt atttcaaacg tccagtgttg tgtgtgaata tgtgttacac ctaggatggg     3540

cattatgcaa aagcacaaag attatatatg acaatcagta ttgcaatgaa agaaaaacta     3600

aaaacagaaa tgatattctc aattttgggc aatgtgagag gtaaaatagc ccttgacatg     3660

atgaacatca cttatttcag cacttggatt gtctggcaat gattactgtg ttgctaactc     3720

attttctttg agttaaagct gtgtatacat tttaaaaggc atatagatag tgtatgcata     3780

tgtatatgta catagggaag ccccatatgt atatagtatg ttgtacactg cacatgtaca     3840

aagaatgtct tcagatcaaa gaaaatttat ctctttttat aaacttaagg acagttgcaa     3900

aaggcttcaa ggaatttatc tcaacattat tctttctatg tcctaactaa atttctcaac     3960

tgttatgaat ttttcatcta cttcttgaac agtggtctat tctgctacat gaagatgaat     4020

acaaacaaaa tttttgtata aactactatt ccagttctcc tgtgtcagtc ttgcctatag     4080

attttgccat cgttttctgt caaagttcct tttgcatgaa acaattatgc aaacttataa     4140

ttattagtgc tgaaaaagag tttattttcc atcttgtttg ttttcctacc ttatgctgag     4200

tagtccagag agttaaaaaa attctctgca tgttggtctt ttaagtctgt tttgctctaa     4260

tcctccatta agcgagcata cctcaagtgg gtctattagc atttaatgac cttttgtgcc     4320

agttgtgcca tcccttaaga tgaaaagttc cttttcttgt gttaatgtac aaagcttttc     4380

ttttggcact gacaactgtg ttctacctgg gaattttgaa tagccatttt catggctgtg     4440

tgttgtgtaa cacaaatgtt tttaaatggt attctcaccc agtaggccag ctctccaaac     4500

gttgcttaga tgcttcaaaa ttagcatatt ttaagtttac cagtataaaa taccaatgca     4560

actactctac atagccaaat gtttgtaaat cacgtcttat tttcctgagg tttttcactc     4620

caccaaatct tacaaatcat tgaaagaaat atattctaac agtacgcact gaatagtgaa     4680

aataattaga cattttaaga accagagcca tagaattatt ttaaattagt agaaaagagg     4740

agctatttcc gaatctatag aataaagtac cacctaaaac tgaattttat catataagca     4800

agtaatacct attagtcata cctaaatttt tcagcacttc attcaattaa aatacatgaa     4860

ttttaaatat tttacatgat gtgaataggc atgataatac ttttagtata aaatctaaac     4920

tttttccatt tatcagaaat gataaaatcc agttaccaca tatcacgttt ataaaatcct     4980

taattaaatg agtaacttct aaaatataac aatactaaat atcacactgc gatggaggtc     5040

ccaaatatgt ggtctatcac cactgaattc atgtaataga taagaaaaaa attagaggtg     5100

gatgtcttgt tttgtgtcat gaattactaa aatctcttag tagttgtggt atatttttga     5160

gtaaaattac catttccaga tttgagtttg aagggctttt atagttgtat tttcctcctc     5220

actgttaata atcataatcc tttttcagta ttttagtggc cttgaacaac tggtttatct     5280

acaatctcaa atcctaagtg tataattatg tgcaatgttc aatacctcat ataatacttg     5340

ctcaacagta tagtggtacc aatggcatta agatggtgtt tttgttctac atatttttca     5400

ataatttatt ctttctaatg ttgaaattat atcaggcttt accggttttt ttagttgttt     5460

aaataagtaa tattttcaaa agaataaaat aaccaatgat atctcttgga ataatctgta     5520

aaacgtagtt ataaaattct attttctact ta                                   5552


<210>  478
<211>  1024
<212>  PRT
<213>  Homo Sapiens

<400>  478

Met Gly Glu Asp Asp Ala Ala Leu Arg Ala Gly Ser Arg Gly Leu Ser 
1               5                   10                  15      


Asp Pro Trp Ala Asp Ser Val Gly Val Arg Pro Arg Thr Thr Glu Arg 
            20                  25                  30          


His Ile Ala Val His Lys Arg Leu Val Leu Ala Phe Ala Val Ser Leu 
        35                  40                  45              


Val Ala Leu Leu Ala Val Thr Met Leu Ala Val Leu Leu Ser Leu Arg 
    50                  55                  60                  


Phe Asp Glu Cys Gly Ala Ser Ala Thr Pro Gly Ala Asp Gly Gly Pro 
65                  70                  75                  80  


Ser Gly Phe Pro Glu Arg Gly Gly Asn Gly Ser Leu Pro Gly Ser Ala 
                85                  90                  95      


Arg Arg Asn His His Ala Gly Gly Asp Ser Trp Gln Pro Glu Ala Gly 
            100                 105                 110         


Gly Val Ala Ser Pro Gly Thr Thr Ser Ala Gln Pro Pro Ser Glu Glu 
        115                 120                 125             


Glu Arg Glu Pro Trp Glu Pro Trp Thr Gln Leu Arg Leu Ser Gly His 
    130                 135                 140                 


Leu Lys Pro Leu His Tyr Asn Leu Met Leu Thr Ala Phe Met Glu Asn 
145                 150                 155                 160 


Phe Thr Phe Ser Gly Glu Val Asn Val Glu Ile Ala Cys Arg Asn Ala 
                165                 170                 175     


Thr Arg Tyr Val Val Leu His Ala Ser Arg Val Ala Val Glu Lys Val 
            180                 185                 190         


Gln Leu Ala Glu Asp Arg Ala Phe Gly Ala Val Pro Val Ala Gly Phe 
        195                 200                 205             


Phe Leu Tyr Pro Gln Thr Gln Val Leu Val Val Val Leu Asn Arg Thr 
    210                 215                 220                 


Leu Asp Ala Gln Arg Asn Tyr Asn Leu Lys Ile Ile Tyr Asn Ala Leu 
225                 230                 235                 240 


Ile Glu Asn Glu Leu Leu Gly Phe Phe Arg Ser Ser Tyr Val Leu His 
                245                 250                 255     


Gly Glu Arg Arg Phe Leu Gly Val Thr Gln Phe Ser Pro Thr His Ala 
            260                 265                 270         


Arg Lys Ala Phe Pro Cys Phe Asp Glu Pro Ile Tyr Lys Ala Thr Phe 
        275                 280                 285             


Lys Ile Ser Ile Lys His Gln Ala Thr Tyr Leu Ser Leu Ser Asn Met 
    290                 295                 300                 


Pro Val Glu Thr Ser Val Phe Glu Glu Asp Gly Trp Val Thr Asp His 
305                 310                 315                 320 


Phe Ser Gln Thr Pro Leu Met Ser Thr Tyr Tyr Leu Ala Trp Ala Ile 
                325                 330                 335     


Cys Asn Phe Thr Tyr Arg Glu Thr Thr Thr Lys Ser Gly Val Val Val 
            340                 345                 350         


Arg Leu Tyr Ala Arg Pro Asp Ala Ile Arg Arg Gly Ser Gly Asp Tyr 
        355                 360                 365             


Ala Leu His Ile Thr Lys Arg Leu Ile Glu Phe Tyr Glu Asp Tyr Phe 
    370                 375                 380                 


Lys Val Pro Tyr Ser Leu Pro Lys Leu Asp Leu Leu Ala Val Pro Lys 
385                 390                 395                 400 


His Pro Tyr Ala Ala Met Glu Asn Trp Gly Leu Ser Ile Phe Val Glu 
                405                 410                 415     


Gln Arg Ile Leu Leu Asp Pro Ser Val Ser Ser Ile Ser Tyr Leu Leu 
            420                 425                 430         


Asp Val Thr Met Val Ile Val His Glu Ile Cys His Gln Trp Phe Gly 
        435                 440                 445             


Asp Leu Val Thr Pro Val Trp Trp Glu Asp Val Trp Leu Lys Glu Gly 
    450                 455                 460                 


Phe Ala His Tyr Phe Glu Phe Val Gly Thr Asp Tyr Leu Tyr Pro Gly 
465                 470                 475                 480 


Trp Asn Met Glu Lys Gln Arg Phe Leu Thr Asp Val Leu His Glu Val 
                485                 490                 495     


Met Leu Leu Asp Gly Leu Ala Ser Ser His Pro Val Ser Gln Glu Val 
            500                 505                 510         


Leu Gln Ala Thr Asp Ile Asp Arg Val Phe Asp Trp Ile Ala Tyr Lys 
        515                 520                 525             


Lys Gly Ala Ala Leu Ile Arg Met Leu Ala Asn Phe Met Gly His Ser 
    530                 535                 540                 


Val Phe Gln Arg Gly Leu Gln Asp Tyr Leu Thr Ile His Lys Tyr Gly 
545                 550                 555                 560 


Asn Ala Ala Arg Asn Asp Leu Trp Asn Thr Leu Ser Glu Ala Leu Lys 
                565                 570                 575     


Arg Asn Gly Lys Tyr Val Asn Ile Gln Glu Val Met Asp Gln Trp Thr 
            580                 585                 590         


Leu Gln Met Gly Tyr Pro Val Ile Thr Ile Leu Gly Asn Thr Thr Ala 
        595                 600                 605             


Glu Asn Arg Ile Ile Ile Thr Gln Gln His Phe Ile Tyr Asp Ile Ser 
    610                 615                 620                 


Ala Lys Thr Lys Ala Leu Lys Leu Gln Asn Asn Ser Tyr Leu Trp Gln 
625                 630                 635                 640 


Ile Pro Leu Thr Ile Val Val Gly Asn Arg Ser His Val Ser Ser Glu 
                645                 650                 655     


Ala Ile Ile Trp Val Ser Asn Lys Ser Glu His His Arg Ile Thr Tyr 
            660                 665                 670         


Leu Asp Lys Gly Ser Trp Leu Leu Gly Asn Ile Asn Gln Thr Gly Tyr 
        675                 680                 685             


Phe Arg Val Asn Tyr Asp Leu Arg Asn Trp Arg Leu Leu Ile Asp Gln 
    690                 695                 700                 


Leu Ile Arg Asn His Glu Val Leu Ser Val Ser Asn Arg Ala Gly Leu 
705                 710                 715                 720 


Ile Asp Asp Ala Phe Ser Leu Ala Arg Ala Gly Tyr Leu Pro Gln Asn 
                725                 730                 735     


Ile Pro Leu Glu Ile Ile Arg Tyr Leu Ser Glu Glu Lys Asp Phe Leu 
            740                 745                 750         


Pro Trp His Ala Ala Ser Arg Ala Leu Tyr Pro Leu Asp Lys Leu Leu 
        755                 760                 765             


Asp Arg Met Glu Asn Tyr Asn Ile Phe Asn Glu Tyr Ile Leu Lys Gln 
    770                 775                 780                 


Val Ala Thr Thr Tyr Ile Lys Leu Gly Trp Pro Lys Asn Asn Phe Asn 
785                 790                 795                 800 


Gly Ser Leu Val Gln Ala Ser Tyr Gln His Glu Glu Leu Arg Arg Glu 
                805                 810                 815     


Val Ile Met Leu Ala Cys Ser Phe Gly Asn Lys His Cys His Gln Gln 
            820                 825                 830         


Ala Ser Thr Leu Ile Ser Asp Trp Ile Ser Ser Asn Arg Asn Arg Ile 
        835                 840                 845             


Pro Leu Asn Val Arg Asp Ile Val Tyr Cys Thr Gly Val Ser Leu Leu 
    850                 855                 860                 


Asp Glu Asp Val Trp Glu Phe Ile Trp Met Lys Phe His Ser Thr Thr 
865                 870                 875                 880 


Ala Val Ser Glu Lys Lys Ile Leu Leu Glu Ala Leu Thr Cys Ser Asp 
                885                 890                 895     


Asp Arg Asn Leu Leu Asn Arg Leu Leu Asn Leu Ser Leu Asn Ser Glu 
            900                 905                 910         


Val Val Leu Asp Gln Asp Ala Ile Asp Val Ile Ile His Val Ala Arg 
        915                 920                 925             


Asn Pro His Gly Arg Asp Leu Ala Trp Lys Phe Phe Arg Asp Lys Trp 
    930                 935                 940                 


Lys Ile Leu Asn Thr Arg Tyr Gly Glu Ala Leu Phe Met Asn Ser Lys 
945                 950                 955                 960 


Leu Ile Ser Gly Val Thr Glu Phe Leu Asn Thr Glu Gly Glu Leu Lys 
                965                 970                 975     


Glu Leu Lys Asn Phe Met Lys Asn Tyr Asp Gly Val Ala Ala Ala Ser 
            980                 985                 990         


Phe Ser Arg Ala Val Glu Thr Val  Glu Ala Asn Val Arg  Trp Lys Met 
        995                 1000                 1005             


Leu Tyr  Gln Asp Glu Leu Phe  Gln Trp Leu Gly Lys  Ala Leu Arg 
    1010                 1015                 1020             


His 
    


<210>  479
<211>  7979
<212>  DNA
<213>  Homo Sapiens

<400>  479
agcccagcct cgggggccag ccccctccgc ccaccgcaca cgggctggcc atgcggcggc       60

tctgaacgat gtcctcctcc tcctacgcca agaacgggac cgcggacggg ccgcactccc      120

ccacctcgca ggtggcccga ggcaccacaa cccggaggag caggttgaaa agatccgatg      180

gcagcaccac ttcgaccagc ttcatcctca gacagggttc agcggattcc tacacaagca      240

ggccgtctga ctccgatgtc tctttggaag aggaccggga agcaattcga caggagagag      300

aacagcaagc agctatccag cttgagagag caaagtccaa acctgtagca tttgccgtga      360

agacaaatgt gagctactgc ggcgccctgg acgaggatgt gcctgttcca agcacagcta      420

tctcctttga tgctaaagac tttctacata ttaaagagaa atataacaat gattggtgga      480

taggaaggct ggtgaaagag ggctgtgaaa ttggcttcat tccaagtcca ctcagattgg      540

agaacatacg gatccagcaa gaacaaaaaa gaggacgttt tcacggaggg aaatcaagtg      600

gaaattcttc ttcaagtctt ggagaaatgg tatctgggac attccgagca actcccacat      660

caacagcaaa acagaagcaa aaagtgacgg agcacattcc tccttacgat gttgtaccgt      720

caatgcgtcc ggtggtgtta gtggggccgt cactgaaagg ttacgaggta acagacatga      780

tgcagaaagc cctctttgat ttcctgaagc acaggtttga tgggaggatt tcaataacga      840

gagtgacagc tgacatttct cttgctaaga ggtctgtcct aaataatccc agcaagagag      900

caataattga acgttcgaac acccggtcca gcttagcgga agtacaaagt gaaattgaaa      960

gaatctttga gttggcaaga tctttgcaac tggttgttct tgatgcagac accatcaatc     1020

acccagcaca acttataaag acttccttag caccaattat tgttcatgta aaagtctcat     1080

ctccaaaggt tttacagcgg ttgattaaat ctagaggaaa gtcacaaagt aaacacttga     1140

atgttcaact ggtggcagct gataaacttg cacaatgccc cccagaaatg tttgatgtta     1200

tattggatga aaatcagctt gaggatgcat gtgaacatct aggggagtac ctggaggcgt     1260

actggcgtgc cacccacaca accagtagca cacccatgac cccgctgctg ggaaggaatt     1320

tgggctccac ggcactctca ccatatccca cagcaatttc tgggttacag agtcagcgaa     1380

tgaggcacag caaccactcc acagagaact ctccaattga aagacgaagt ctaatgacct     1440

ctgatgaaaa ttatcacaat gaaagggctc ggaagagtag gaaccgcttg tcttccagtt     1500

ctcagcatag ccgagatcat taccctcttg tggaagaaga ttaccctgac tcataccagg     1560

acacttacaa accccatagg aaccgaggat cacctggggg atatagccat gactcccgac     1620

ataggctttg agtctaatga aacaaaaaat attcatctgt tgacaatttg ccatagcagt     1680

gctaggataa accaatcatc ttaacttggc taacatagca cagtatttac tgtgctaatg     1740

ggctgctgtc attttatgct aagtaagggg caaaaaaaaa aattacatta tgcccttgag     1800

tctagatgga tattagatgc ccgatcatat agatattttt aagtgcaaca tttacatgat     1860

aacagtacat tttgttttct tcatagattt agacacatca atttgtaatt tagggtactt     1920

acaaggcaca tataaaataa tttcccatgc tggaaattcc aaatgaccag ttccagttgg     1980

aaccaattta taaaccaatt cctgttggaa tttgggtgaa ttgactagaa agtctacttg     2040

agcatgttgt aatcaactga aaaatctggg gggaaaaaaa aaaaactaat aagaaaatcg     2100

aaataccaat agaagccaaa tccagctttg gtatttattt gctggaagct aaatttacac     2160

ttaaagttgg agtgtataaa cattttaata tatgttaatg ttgccagaat gacttttcag     2220

acttaccaaa tgtattgata gtgccaaaaa aaaaatctca gaaatcttaa tgcagaaatt     2280

atatagtctc ctcagatttt aatattttta tttctttcct ggcacagctg ttgtattcaa     2340

agtgttttgc tttttgtttg gtcagtactg ttagctcatt tgaagttggc aaaaacaaat     2400

acaaacaagc aaaaaacctc aaattttttt cagcagtgag agagaatagt aaagagaggc     2460

ccaagcatag ctggttatgt gaaatataaa atggggtgtt gttctccctt taatcaatct     2520

gagcacaact acatacatcc aggaatctga agtcagatag taaggatgtg gtaccaatcc     2580

tcccgagtgc aatgctaaac acttccaggt gggaattcat ctatttcact taacacaaac     2640

gcagggtctg tatttcctgc caacaagatt gagtatcttt ccattgcttc tctcagtctc     2700

tgtctttgaa tatctgaatg ttctggccct tcaacaaatt ctttaaatca tgctaaggaa     2760

tttcgtttta tgtggacaca ctcaactttg atattcagga gatgttttta caaaatgact     2820

aattgaaaaa agttgaaaca aatgatttta aaagcttgca gtaaaaaata aactcataga     2880

ttcagcaaat atttgttgac taaaattata gcatttttaa tgcagaaaat tataaagaat     2940

ttggagattg agctgcctta tttctaatga acactcctct tcatcttatt aagtcttcac     3000

agtttttcca gtggctataa ttatggaatt ggtgacctat gttttatatt atcaaggaag     3060

ccttagattc actctgatct aagaaattat tgaaattgac cctttttaca caaatgtctt     3120

taaaaaaaaa aacttatttc taaatgtcca tagtgcatgc attttctaaa accccaataa     3180

gtccagccat aaaagttctt ttctgctagt acatgtcatg aagcctattt ttgaaaataa     3240

tgataattaa ttttatagta tcttcttttc tccccaagcc tttcagtatt caggcactca     3300

aagcatgcac cagttcagta atcttcttga ccatggaaat aagttccaca ttactgatga     3360

gttatatata tatcttgaac cccattacaa cctcaccaca tccccctgca tttatgttca     3420

gtgtttgtac cccattatga acctgtttag ctgataatga ggatacctat aattctgtaa     3480

gtcatttcaa atatttgata caattaaaaa atatgggctt agtaaatttt aaaagttaac     3540

atgtgatact ggcttgtgag attcttctgt catctagtga agcttataaa actttcagtt     3600

aagacatttt aaaagagtta tatccattag gcactttaat aaacatataa cctgccatta     3660

ctgaatactt tgttagaaca cagaagagca tcttccagca aacaaaaata tatttattac     3720

atgtacagca catacttgca tgagaaagaa aacattagcc aaaacatttt tctatatgct     3780

ttactggttt cttgtttatg cgcattaaag tatttaattg caaagagtgc accaaggtgt     3840

acaaatttag actagacagc tgttcagctt tttctgtagt agcattagca gtttggtcat     3900

ttaactactt taagatactt acattttatg gcaggtagct gtaacagcat ttaaatatat     3960

ttcctagtca tcaagattac catcttcttt caacttttta aaagtcactt gtttttaaag     4020

gtttttcaaa gccttgtttt tagtcttcca tgtcatgccg ataaagagag tctcattcaa     4080

tatctgtgca caaaaccaat ctatcaatta ccatcagatg tccatacctg ttttgctttg     4140

cattcttatt caaaagctga caatcttgga aagggtataa tgtatatttt attgatggat     4200

atatttaaat gtttacttta atttggaata ttctttcccc ttctttctgt aataagttta     4260

tcttcctcaa ataaggggat atacatctta ttttttttaa agacttaaga gtttattgtg     4320

taaatgatac ttaaaatcta gatatatact aaatgaaaag ttttattttt gccaagcaca     4380

ccaagcacct ttgaaaaata catactccat actttgtttt taattaattt catttaaaga     4440

tagcaaatga ttataagcaa gagaaacaag tcttttactg ttttgaggct gttttaactt     4500

acagtataag ccacatacta gaattctgta atttcagtca cagacatata ataatgtgga     4560

ctcatgtgac aatgtggaaa tgtagttctg gaaaaaaacg aatgcaattt gtcaatcctg     4620

atgttaattc tcaagggtat aatgtcactc taatattata accaacaaca ttatcttgtt     4680

taatatttaa agcaacactt agaaatgttt ataaatgatg attctctctt atctttatac     4740

agttctattg gagagaaggt tgaaattgtt cacaatttag atgatggtct ttcctaataa     4800

gagtcttaat tttgtgacta tataagtcat tgcagttagt ctttaatgaa atgaatttta     4860

ttaatgtaaa acaaattctg agacaattat ttgtttcctt taaataatct gctatttaat     4920

tattattgtc gttgtttgca aaatgtattt ttggaatgtt aacctctttt catacctgca     4980

tacttgaact tgtcttttgt gtgggggcct taaaattcat aataggaagt ggaggcagtg     5040

aaaggaagta agaaaaggaa attatgctaa aagatggttt gcaaatttaa attctttaaa     5100

tgaacatatc acaaaatgtt gttaagaccc aggatgtccg ttaagaatgt gtcttggcaa     5160

ccttaatttg catgttagta tatattttct tagttacaca gttttatttt ggtatttgct     5220

taaaaaatgt aataccattg tagaaattac cctatgtact gatatattta ctacctcttc     5280

tctagagaag acaatctgtc tttaaaggga aaaacactgg tcaataagta gtgatcaaaa     5340

ttatcactat tctggctaac cttgctgcaa agctaaatac atagattatt aaaatatgcc     5400

ttccctttag attttaaact gtttccaaaa tgctgtttgg caccctttca tttcttccac     5460

gttagtgaag ttttctttga attggttcac agtttatcat gaggcaaggt taatttaaca     5520

aataagtcat catagggaac aaaacaaact gcaagggaat tgcctttgtg tgcaacttgt     5580

tataatatct agttctaagt ctaaaggagt aaaagtccaa agactttatg tttaagagca     5640

gctggtttgc aaattcacat tttgttggtc cttgacttcc acagagcatg acttagccat     5700

ttactgggta aggatatgca taatcttgga ctcccatgta attggaataa acttcatatc     5760

aatgtttcaa ataaatgcta tgtacccctt attcctttta catttctgcc tttgtctttt     5820

atgacaatgt tgcatgttgt gtttttttaa attatataaa actcatcctt gaatgactgt     5880

atgaatgaaa aatttatagg aaattatgta ataaaatctg ttttattagt ttctcatacc     5940

tttaaatact gtcaatacta taactgttag taagttactt actcaagctg tgtctatggg     6000

gcagagaaca gtcctcttct ttaaaataat catgatcaaa ccagtcaagt caatccaatt     6060

agctgttaga cagacaataa ggataacctt ctttttgact taagcagtca agttagtcaa     6120

aatagaaaaa ttggcttata tgggcaccca gaactacagc attcaaaaat tacttttaaa     6180

agtttcttct tttattaaaa tggactttct taaataaaat acatcctctg atagcagcta     6240

tctcttttta cttgtaatga ttaattctaa atgcttcatg taattgaggg acattatgag     6300

aagactagaa agtatctcat cagataatcc taagggctgt aacttctact tgccataaac     6360

aaagtataat taagagtgag tagcaattgg tttggggagt cgtagttata tatgaaactt     6420

tcttttgttt ctcatgatgt atgtaaaatg tttgcagaag gatggtagaa aatgttacta     6480

atgaatttag agtggtttgg gagaatacac tgatacttcc tcatttgaaa attataagga     6540

gttacaaggg gaactaagaa ccagaagtgg ctggcctcta gcttttcaat acctgataag     6600

tgttcttggt tatgttttga acacttaaat ttctcaacaa atggctatgt ctatatttat     6660

gtaggggcca cccttgccct acttgcatgc cactttgact tttaactgaa atcagtgtga     6720

attctgtatg cataagggat gtaataaaga ggcgggatca ttaacgctat atcgttgcat     6780

actatttttc atatgcctta caatattttc tgggatgtta ttaaaatgaa agcattttat     6840

tgccaaaata aatctatgtt gttacttata atctgcatta gcagtagaaa aataatgtag     6900

caaaaacata ttgtacagta caaaattata aaatatatat tttgccaata atataaaaat     6960

agattgagga gaaagaagca catttgttat agcacaaact tataacaaaa tccaccgtta     7020

aatttggcag tcatattttt taaaagtatg tcgatttagt tctaagtttt gtcagattta     7080

cttcatctac catcttttta acttgctgct tgatactttt ccagcaattt atttcatagc     7140

cttgcaatct gtggatgtaa tttcttttgt tttattccct tccataaaat ttattaaatt     7200

ttattttgtg ataacactca taccatattt tctcctctta tttcttctct ttcaataaca     7260

acagcagaaa gtcacagcaa gtgagctcat agggctcctc tgaattttgg acatgtgtga     7320

gatttttgta tttttcacag cctcgagtca gaatgatcaa taaagatgtc ccaaccacaa     7380

aaaattatat tagttaggga ttctttaatt tgttttgtac tgaatactac tttgaaacat     7440

aagttaaagc cattagctgt gtttttgtag ggatggtggg aaggaataaa aaataaatgt     7500

attaacataa aacatactaa aacagaaata tggcaaaatg atgtaaaaag atttttccta     7560

ctattctgag ggctgttgaa atcccaggct attgctatat ctccattgac aaagtgggat     7620

aaaaaatgcc tttgtcaaat aatttttttt ctttctttaa attttagtta tttattttaa     7680

taatttgtcc ccttttattt ttcttatcta ggtatgtgta gcattctaca aggcatgctg     7740

ggtaaaatat actatgcaaa tgtgtacagt gctgcatgtt ttgttctccc tctgctttag     7800

tggctttaaa gaaaaaaacg tggtgttatt tttgtgaata aaaacattaa caaagaaaat     7860

gcagagtgca tgcatagagt atcctcattt ctatggattt gttttatgga atttaaatgt     7920

gtacaaaaca actgcattac tttttttctt ttatataata aatgaaaaaa acactgaaa      7979


<210>  480
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  480

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
1               5                   10                  15      


Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
            20                  25                  30          


Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
        35                  40                  45              


Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
    50                  55                  60                  


Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
65                  70                  75                  80  


Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                85                  90                  95      


Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
            100                 105                 110         


Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
        115                 120                 125             


Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
    130                 135                 140                 


Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
145                 150                 155                 160 


Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                165                 170                 175     


Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
            180                 185                 190         


Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
        195                 200                 205             


His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
    210                 215                 220                 


Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
225                 230                 235                 240 


Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                245                 250                 255     


Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
            260                 265                 270         


Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
        275                 280                 285             


Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
    290                 295                 300                 


Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
305                 310                 315                 320 


Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                325                 330                 335     


Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
            340                 345                 350         


Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
        355                 360                 365             


Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
    370                 375                 380                 


Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
385                 390                 395                 400 


Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                405                 410                 415     


Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
            420                 425                 430         


Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
        435                 440                 445             


Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
    450                 455                 460                 


Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
465                 470                 475                 480 


Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                485                 490                 495     


Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
            500                 505                 510         


Ser His Asp Ser Arg His Arg Leu 
        515                 520 


<210>  481
<211>  2594
<212>  DNA
<213>  Homo Sapiens

<400>  481
gccctaacct tcccagggct cagctctttg gagctgccca ttcctccggc tgcgagaaag       60

gacgcgcgcc ctgcgtcggg cgaagaaaag aagcaaaact tgtcgggagg gtttcgtcat      120

caacctcctt cccgcaaacc taaacctcct gccggggcca tccctagaca gaggaaagtt      180

cctgcagagc cgaccagccc tagtggatct ggggcaggca gcggcgctgg ctgtggaatt      240

agatctgttt tgaacccagt ggagcgcatc gctggggctc ggaagtcacc gtccgcgggc      300

accgggttgg cgctgcccga gtggaaccga cagtttgcga gcctcggctg caagtggcct      360

ctcctccccg cggttgttgt tcagtgtcgg gtgagggctg cgagtgtggc aagttgcaaa      420

gagagcctca gaggtccgaa gagcgctgcg ctcctactcg cgttcgcttc ttcctcttct      480

cggttcccta ctgtgaaatc gcagcgacat ttacaaaggc ctccgggtcc taccgagacc      540

gatccgcagc gtttggcccg gtcgtgccta ttgcatcggg agcccccgag caccggcgaa      600

ggactggcgg gtggggtagg gaggtggcgg cggcggcatg gcgaggttcc cgaaggccga      660

cctggccgct gcaggagtta tgttactttg ccacttcttc acggaccagt ttcagttcgc      720

cgatgggaaa cccggagacc aaatccttga ttggcagtat ggagttactc aggccttccc      780

tcacacagag gaggaggtgg aagttgattc acacgcgtac agccacaggt ggaaaagaaa      840

cttggacttt ctcaaggcgg tagacacgaa ccgagcaagc gtcggccaag actctcctga      900

gcccagaagc ttcacagacc tgctgctgga tgatgggcag gacaataaca ctcagatcga      960

ggaggataca gaccacaatt actatatatc tcgaatatat ggtccatctg attctgccag     1020

ccgggattta tgggtgaaca tagaccaaat ggaaaaagat aaagtgaaga ttcatggaat     1080

attgtccaat actcatcggc aagctgcaag agtgaatctg tccttcgatt ttccatttta     1140

tggccacttc ctacgtgaaa tcactgtggc aaccgggggt ttcatataca ctggagaagt     1200

cgtacatcga atgctaacag ccacacagta catagcacct ttaatggcaa atttcgatcc     1260

cagtgtatcc agaaattcaa ctgtcagata ttttgataat ggcacagcac ttgtggtcca     1320

gtgggaccat gtacatctcc aggataatta taacctggga agcttcacat tccaggcaac     1380

cctgctcatg gatggacgaa tcatctttgg atacaaagaa attcctgtct tggtcacaca     1440

gataagttca accaatcatc cagtgaaagt cggactgtcc gatgcatttg tcgttgtcca     1500

caggatccaa caaattccca atgttcgaag aagaacaatt tatgaatacc accgagtaga     1560

gctacaaatg tcaaaaatta ccaacatttc ggctgtggag atgaccccat tacccacatg     1620

cctccagttt aacagatgtg gcccctgtgt atcttctcag attggcttca actgcagttg     1680

gtgtagtaaa cttcaaagat gttccagtgg atttgatcgt catcggcagg actgggtgga     1740

cagtggatgc cctgaagagt caaaagagaa gatgtgtgag aatacagaac cagtggaaac     1800

ttcttctcga accaccacaa ccgtaggagc gacaaccacc cagttcaggg tcctaactac     1860

caccagaaga gcagtgactt ctcagtttcc caccagcctc cctacagaag atgataccaa     1920

gatagcacta catctaaaag ataatggagc ttctacagat gacagtgcag ctgagaagaa     1980

agggggaacc ctccacgctg gcctcatcat tggaatcctc atcctggtcc tcattgtagc     2040

cacagccatt cttgtgacag tctatatgta tcaccaccca acatcagcag ccagcatctt     2100

ctttattgag agacgcccaa gcagatggcc tgcgatgaag tttagaagag gctctggaca     2160

tcctgcctat gctgaagttg aaccagttgg agagaaagaa ggctttattg tatcagagca     2220

gtgctaaaat ttctaggaca gaacaacacc agtactggtt tacaggtgtt aagactaaaa     2280

ttttgcctat acctttaaga caaacaaaca aacacacaca caaacaagct ctaagctgct     2340

gtagcctgaa gaagacaaga tttctggaca agctcagccc aggaaacaaa gggtaaacaa     2400

aaaactaaaa cttatacaag ataccattta cactgaacat agaattccct agtggaatgt     2460

catctatagt tcactcggaa catctcccgt ggacttatct gaagtatgac aagattataa     2520

tgcttttggc ttaggtgcag ggttgcaaag ggatcagaaa aaaaaaatca taataaagct     2580

ttagttcatg aggg                                                       2594


<210>  482
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  482

Met Ala Arg Phe Pro Lys Ala Asp Leu Ala Ala Ala Gly Val Met Leu 
1               5                   10                  15      


Leu Cys His Phe Phe Thr Asp Gln Phe Gln Phe Ala Asp Gly Lys Pro 
            20                  25                  30          


Gly Asp Gln Ile Leu Asp Trp Gln Tyr Gly Val Thr Gln Ala Phe Pro 
        35                  40                  45              


His Thr Glu Glu Glu Val Glu Val Asp Ser His Ala Tyr Ser His Arg 
    50                  55                  60                  


Trp Lys Arg Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala 
65                  70                  75                  80  


Ser Val Gly Gln Asp Ser Pro Glu Pro Arg Ser Phe Thr Asp Leu Leu 
                85                  90                  95      


Leu Asp Asp Gly Gln Asp Asn Asn Thr Gln Ile Glu Glu Asp Thr Asp 
            100                 105                 110         


His Asn Tyr Tyr Ile Ser Arg Ile Tyr Gly Pro Ser Asp Ser Ala Ser 
        115                 120                 125             


Arg Asp Leu Trp Val Asn Ile Asp Gln Met Glu Lys Asp Lys Val Lys 
    130                 135                 140                 


Ile His Gly Ile Leu Ser Asn Thr His Arg Gln Ala Ala Arg Val Asn 
145                 150                 155                 160 


Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Phe Leu Arg Glu Ile Thr 
                165                 170                 175     


Val Ala Thr Gly Gly Phe Ile Tyr Thr Gly Glu Val Val His Arg Met 
            180                 185                 190         


Leu Thr Ala Thr Gln Tyr Ile Ala Pro Leu Met Ala Asn Phe Asp Pro 
        195                 200                 205             


Ser Val Ser Arg Asn Ser Thr Val Arg Tyr Phe Asp Asn Gly Thr Ala 
    210                 215                 220                 


Leu Val Val Gln Trp Asp His Val His Leu Gln Asp Asn Tyr Asn Leu 
225                 230                 235                 240 


Gly Ser Phe Thr Phe Gln Ala Thr Leu Leu Met Asp Gly Arg Ile Ile 
                245                 250                 255     


Phe Gly Tyr Lys Glu Ile Pro Val Leu Val Thr Gln Ile Ser Ser Thr 
            260                 265                 270         


Asn His Pro Val Lys Val Gly Leu Ser Asp Ala Phe Val Val Val His 
        275                 280                 285             


Arg Ile Gln Gln Ile Pro Asn Val Arg Arg Arg Thr Ile Tyr Glu Tyr 
    290                 295                 300                 


His Arg Val Glu Leu Gln Met Ser Lys Ile Thr Asn Ile Ser Ala Val 
305                 310                 315                 320 


Glu Met Thr Pro Leu Pro Thr Cys Leu Gln Phe Asn Arg Cys Gly Pro 
                325                 330                 335     


Cys Val Ser Ser Gln Ile Gly Phe Asn Cys Ser Trp Cys Ser Lys Leu 
            340                 345                 350         


Gln Arg Cys Ser Ser Gly Phe Asp Arg His Arg Gln Asp Trp Val Asp 
        355                 360                 365             


Ser Gly Cys Pro Glu Glu Ser Lys Glu Lys Met Cys Glu Asn Thr Glu 
    370                 375                 380                 


Pro Val Glu Thr Ser Ser Arg Thr Thr Thr Thr Val Gly Ala Thr Thr 
385                 390                 395                 400 


Thr Gln Phe Arg Val Leu Thr Thr Thr Arg Arg Ala Val Thr Ser Gln 
                405                 410                 415     


Phe Pro Thr Ser Leu Pro Thr Glu Asp Asp Thr Lys Ile Ala Leu His 
            420                 425                 430         


Leu Lys Asp Asn Gly Ala Ser Thr Asp Asp Ser Ala Ala Glu Lys Lys 
        435                 440                 445             


Gly Gly Thr Leu His Ala Gly Leu Ile Ile Gly Ile Leu Ile Leu Val 
    450                 455                 460                 


Leu Ile Val Ala Thr Ala Ile Leu Val Thr Val Tyr Met Tyr His His 
465                 470                 475                 480 


Pro Thr Ser Ala Ala Ser Ile Phe Phe Ile Glu Arg Arg Pro Ser Arg 
                485                 490                 495     


Trp Pro Ala Met Lys Phe Arg Arg Gly Ser Gly His Pro Ala Tyr Ala 
            500                 505                 510         


Glu Val Glu Pro Val Gly Glu Lys Glu Gly Phe Ile Val Ser Glu Gln 
        515                 520                 525             


Cys 
    


<210>  483
<211>  5275
<212>  DNA
<213>  Homo Sapiens

<400>  483
gagggcgggg cgcaggcgcg gttagtaccg cggtgggcgc cggggctccc gggaatctac       60

cttctcctgc ggccggcacg cggttcccag ggggccagcg gcggtcagcc gaggtcgaga      120

cgcccgcagg gtggccttag cggccggtcg taccacggca gccccgccga tcaggttcct      180

ttgggagact tcgacttgtt ggcgaaatga accggagaag aatcccaatt gggaattgcg      240

gaaaacagga ctctagggta gagaaaggtt gtagaaccaa tagggtttga gacctgatgg      300

ccaaaagaaa ggaagaaaat ttttcctctc ctaaaaatgc caaaaggcca agacaagaag      360

aattggagga ttttgataaa gatggtgacg aagacgaatg taaaggtact actttgactg      420

cagcagaagt tggaataatt gagagtattc acctaaaaaa cttcatgtgt cattcaatgc      480

ttggaccttt taagtttggt tctaatgtca actttgttgt tggcaacaat ggaagtggga      540

agagtgcagt actcacagct ctcatagtcg gtcttggtgg aagagcagtt gctactaata      600

gaggatcctc tttaaaaggt tttgtgaaag atggacagaa ctctgcagat atctcaataa      660

cattgaggaa cagaggagat gatgccttta aagccagtgt gtatggtaac tctatactta      720

tacagcaaca catcagcata gatggaagtc gatcttataa acttaaaagt gcaacaggct      780

ccgtggtttc cacgaggaaa gaagagctga ttgcaattct tgatcatttt aacatccagg      840

tggataatcc agtttctgtt ttaacacaag aaatgagcaa gcagttctta cagtctaaaa      900

atgaaggaga caaatacaaa ttcttcatga aagcaacgca acttgaacag atgaaggaag      960

attattcata cattatggaa acgaaagaaa gaacaaagga gcagatacat caaggagaag     1020

agcggcttac tgaactaaag cgccagtgtg tagagaaaga ggaacgtttt caaagtattg     1080

ctggtttaag tacaatgaag actaatttag agtccttgaa acatgaaatg gcttgggcag     1140

tggtcaatga aattgaaaaa caattgaatg ccatcagaga taatatcaaa attggagaag     1200

atcgtgctgc tagacttgac aggaaaatgg aagaacagca ggtcagactt aatgaggcag     1260

aacaaaagta caaggatatt caagacaaac tagaaaagat tagtgaagag acaaatgcac     1320

gagcaccaga atgtatggca ttgaaagcag atgttgttgc taagaaaagg gcctataatg     1380

aagctgaggt tttatataac cgatccttaa acgaatataa agcattaaag aaagatgatg     1440

agcagctttg taaacgaatt gaagagctga aaaaaagtac tgaccaatct ttggaacctg     1500

aacggttgga aagacaaaaa aaaatatctt ggttaaaaga gagagtaaag gcctttcaaa     1560

atcaagaaaa ttcagtcaat caagagatcg aacagtttca gcaagccata gaaaaggaca     1620

aagaagaaca tggcaaaatt aagagagaag aattagatgt gaagcatgca ctgagctaca     1680

atcagaggca actgaaagaa ttgaaagata gtaaaactga tcgactcaaa agatttggcc     1740

ctaatgttcc agctcttctt gaagccatag atgatgctta tagacaagga cattttacct     1800

ataaacctgt aggcccttta ggagcttgca ttcatcttcg ggacccagaa cttgctttgg     1860

ctattgaatc ttgcttaaaa gggcttctgc aggcctattg ttgccataat catgctgatg     1920

aaagggtcct tcaggcactc atgaaaaggt tttatttacc agggacctca cggccaccga     1980

taatagtttc tgagtttcgg aatgagatat atgatgtaag acacagagct gcttatcatc     2040

cagactttcc aacagttctg acagctttag aaatagataa tgcggttgtg gcaaatagcc     2100

taattgacat gagaggcata gagacagtgc tactaatcaa aaataattct gtagctcgtg     2160

cagtaatgca gtcccaaaag ccacccaaaa attgtagaga agcttttact gctgatggtg     2220

atcaagtttt tgcaggacgt tattattcat ctgaaaatac aagacctaag ttcctaagca     2280

gagatgtgga ttctgaaata agtgacttgg agaatgaggt tgaaaataag acggcccaga     2340

tattaaatct tcagcaacat ttatctgccc ttgaaaaaga tattaaacac aatgaggaac     2400

ttcttaaaag gtgccaacta cattataaag aactaaagat gaaaataaga aaaaatattt     2460

ctgaaattcg ggaacttgag aacatagaag aacaccagtc tgtagatatt gcaactttgg     2520

aagatgaagc tcaggaaaat aaaagcaaaa tgaaaatggt tgaggaacat atggagcaac     2580

aaaaagaaaa tatggagcat cttaaaagtc tgaaaataga agcagaaaat aagtatgatg     2640

caattaaatt caaaattaat caactatcgg agctagcaga cccacttaag gatgaattaa     2700

accttgctga ttctgaagtg gataaccaaa aacgagggaa acgacattat gaagaaaaac     2760

aaaaagaaca cttggatacc ttaaataaaa agaaacgaga actggatatg aaagagaaag     2820

aactagagga gaaaatgtca caagcaagac aaatctgccc agagcgtata gaagtagaaa     2880

aatctgcatc aattctggac aaagaaatta atcgattaag gcagaagata caggcagaac     2940

atgctagtca tggagatcga gaggaaataa tgaggcagta ccaagaagca agagagacct     3000

atcttgatct ggatagtaaa gtgaggactt taaaaaagtt tattaaatta ctgggagaaa     3060

tcatggagca cagattcaag acatatcaac aatttagaag gtgtttgact ttacgatgca     3120

aattatactt tgacaactta ctatctcagc gggcctattg tggaaaaatg aattttgacc     3180

acaagaatga aactctaagt atatcagttc agcctggaga aggaaataaa gctgctttca     3240

atgacatgag agccttgtct ggaggtgaac gttctttctc cacagtgtgt tttattcttt     3300

ccctgtggtc catcgcagaa tctcctttca gatgcctgga tgaatttgat gtctacatgg     3360

atatggttaa taggagaatt gccatggact tgatactgaa gatggcagat tcccagcgtt     3420

ttagacagtt tatcttgctc acacctcaaa gcatgagttc acttccatcc agtaaactga     3480

taagaattct ccgaatgtct gatcctgaaa gaggacaaac tacattgcct ttcagacctg     3540

tgactcaaga agaagatgat gaccaaaggt gatttgtaac ttaacatgcc ttgtcctgat     3600

gttgaaggat ttgtgaaggg aaaaaaaatt ctggactctt tgatataata aaatgagact     3660

ggaggcattc tgaaatgaaa gaaactcctt tatatatcca accacaatca aacatataaa     3720

taagcctgga aaaccaacta caacctgcaa tttaagatta ctattacttt aagaaaatca     3780

atttcatagt attggtttta aatcttttta agttttttta atacgatcta tttttatagg     3840

ttctttttca gaagtaaaat tttgtacata tatacatgta catatctgtt tagtttgggt     3900

tcatttctat aacattttgt aagaaaataa aagtttgagc acctgattat atttagtttt     3960

gcttttccag atattacatt ctatagttac caaaaatggt tgaagggagg gatttctcat     4020

tgcagagggt ggggtgcaag ggaataagac acttgtacgg aacactgaag ctttgccaac     4080

ttctacacat gccttttttg cagtccttta actgtccacc ctaccaagag cttataacca     4140

gtatcagaac tggataatga cgcagttttt cactctgacc tccatcatgc ttgcctgatt     4200

taaaagccct cagtttgcag tccagggact gttcaggctt gtcctcagct gagaggacac     4260

aggctagagg gactgtgcag aaccaggctg ggagaagggc tgggaaaact gggagtggag     4320

ggtggatcct catggagcag gagagtagct catggctcca ggagcctgag gccatgcagt     4380

tgatggtgag ctgacatcaa ttctaagact catcctaatt gaggggtgtt aaaaagtgtg     4440

ctgcttagaa tgaccaaata tagttattgt aaaaaatgat atttatgaac tttttatttt     4500

agaaaacatg aattttattg ctccctgtat tatttgtttg atactaggat tcatgctaaa     4560

ctttttaaga atgtattgga tatcaagaag cattccttac attagtagca ataaatatta     4620

gaataaatat gaaattgaac tattttcaga aaaagggcag tatattaaga gcagggactg     4680

ttctctagtt attgaggaaa actggacttt gtttgtgttt ttggtggagg aagaagttta     4740

agatacttta gtcttaaatt gaggtttgcc aaatgagaag ttcaaaaact tgggctttct     4800

aatcagaatt tccaggagga ggaaagtgtg tgctgaatat tttaaacatt tcccactgat     4860

catacaaagt ctgattttta aatttacact tataatgcct ttgtattaaa attattttta     4920

acatgtgctt ttccaaatta aaaatgaagt agagtatacc aaatgcataa actttcatta     4980

gctaaggaac tcatgtctga attttgttgt agttttgaat gttgtgctct ttcatacaga     5040

atgggaaaca taatcctcag gtatcccagc atctcttgtt gaattgaaga ttattcattg     5100

ctttggcctc acaaagtttt gatttcaact atcataagtg aaaatatctt cctttaatgt     5160

tctaagtagt gataatatta ctagaatgaa agaataaaaa gaaattgttc ttttaaaata     5220

tgtgtaactt ctaaaaataa aacttaaaat ttatatgtaa aaaaaaaaaa aaaaa          5275


<210>  484
<211>  1091
<212>  PRT
<213>  Homo Sapiens

<400>  484

Met Ala Lys Arg Lys Glu Glu Asn Phe Ser Ser Pro Lys Asn Ala Lys 
1               5                   10                  15      


Arg Pro Arg Gln Glu Glu Leu Glu Asp Phe Asp Lys Asp Gly Asp Glu 
            20                  25                  30          


Asp Glu Cys Lys Gly Thr Thr Leu Thr Ala Ala Glu Val Gly Ile Ile 
        35                  40                  45              


Glu Ser Ile His Leu Lys Asn Phe Met Cys His Ser Met Leu Gly Pro 
    50                  55                  60                  


Phe Lys Phe Gly Ser Asn Val Asn Phe Val Val Gly Asn Asn Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Val Leu Thr Ala Leu Ile Val Gly Leu Gly Gly Arg 
                85                  90                  95      


Ala Val Ala Thr Asn Arg Gly Ser Ser Leu Lys Gly Phe Val Lys Asp 
            100                 105                 110         


Gly Gln Asn Ser Ala Asp Ile Ser Ile Thr Leu Arg Asn Arg Gly Asp 
        115                 120                 125             


Asp Ala Phe Lys Ala Ser Val Tyr Gly Asn Ser Ile Leu Ile Gln Gln 
    130                 135                 140                 


His Ile Ser Ile Asp Gly Ser Arg Ser Tyr Lys Leu Lys Ser Ala Thr 
145                 150                 155                 160 


Gly Ser Val Val Ser Thr Arg Lys Glu Glu Leu Ile Ala Ile Leu Asp 
                165                 170                 175     


His Phe Asn Ile Gln Val Asp Asn Pro Val Ser Val Leu Thr Gln Glu 
            180                 185                 190         


Met Ser Lys Gln Phe Leu Gln Ser Lys Asn Glu Gly Asp Lys Tyr Lys 
        195                 200                 205             


Phe Phe Met Lys Ala Thr Gln Leu Glu Gln Met Lys Glu Asp Tyr Ser 
    210                 215                 220                 


Tyr Ile Met Glu Thr Lys Glu Arg Thr Lys Glu Gln Ile His Gln Gly 
225                 230                 235                 240 


Glu Glu Arg Leu Thr Glu Leu Lys Arg Gln Cys Val Glu Lys Glu Glu 
                245                 250                 255     


Arg Phe Gln Ser Ile Ala Gly Leu Ser Thr Met Lys Thr Asn Leu Glu 
            260                 265                 270         


Ser Leu Lys His Glu Met Ala Trp Ala Val Val Asn Glu Ile Glu Lys 
        275                 280                 285             


Gln Leu Asn Ala Ile Arg Asp Asn Ile Lys Ile Gly Glu Asp Arg Ala 
    290                 295                 300                 


Ala Arg Leu Asp Arg Lys Met Glu Glu Gln Gln Val Arg Leu Asn Glu 
305                 310                 315                 320 


Ala Glu Gln Lys Tyr Lys Asp Ile Gln Asp Lys Leu Glu Lys Ile Ser 
                325                 330                 335     


Glu Glu Thr Asn Ala Arg Ala Pro Glu Cys Met Ala Leu Lys Ala Asp 
            340                 345                 350         


Val Val Ala Lys Lys Arg Ala Tyr Asn Glu Ala Glu Val Leu Tyr Asn 
        355                 360                 365             


Arg Ser Leu Asn Glu Tyr Lys Ala Leu Lys Lys Asp Asp Glu Gln Leu 
    370                 375                 380                 


Cys Lys Arg Ile Glu Glu Leu Lys Lys Ser Thr Asp Gln Ser Leu Glu 
385                 390                 395                 400 


Pro Glu Arg Leu Glu Arg Gln Lys Lys Ile Ser Trp Leu Lys Glu Arg 
                405                 410                 415     


Val Lys Ala Phe Gln Asn Gln Glu Asn Ser Val Asn Gln Glu Ile Glu 
            420                 425                 430         


Gln Phe Gln Gln Ala Ile Glu Lys Asp Lys Glu Glu His Gly Lys Ile 
        435                 440                 445             


Lys Arg Glu Glu Leu Asp Val Lys His Ala Leu Ser Tyr Asn Gln Arg 
    450                 455                 460                 


Gln Leu Lys Glu Leu Lys Asp Ser Lys Thr Asp Arg Leu Lys Arg Phe 
465                 470                 475                 480 


Gly Pro Asn Val Pro Ala Leu Leu Glu Ala Ile Asp Asp Ala Tyr Arg 
                485                 490                 495     


Gln Gly His Phe Thr Tyr Lys Pro Val Gly Pro Leu Gly Ala Cys Ile 
            500                 505                 510         


His Leu Arg Asp Pro Glu Leu Ala Leu Ala Ile Glu Ser Cys Leu Lys 
        515                 520                 525             


Gly Leu Leu Gln Ala Tyr Cys Cys His Asn His Ala Asp Glu Arg Val 
    530                 535                 540                 


Leu Gln Ala Leu Met Lys Arg Phe Tyr Leu Pro Gly Thr Ser Arg Pro 
545                 550                 555                 560 


Pro Ile Ile Val Ser Glu Phe Arg Asn Glu Ile Tyr Asp Val Arg His 
                565                 570                 575     


Arg Ala Ala Tyr His Pro Asp Phe Pro Thr Val Leu Thr Ala Leu Glu 
            580                 585                 590         


Ile Asp Asn Ala Val Val Ala Asn Ser Leu Ile Asp Met Arg Gly Ile 
        595                 600                 605             


Glu Thr Val Leu Leu Ile Lys Asn Asn Ser Val Ala Arg Ala Val Met 
    610                 615                 620                 


Gln Ser Gln Lys Pro Pro Lys Asn Cys Arg Glu Ala Phe Thr Ala Asp 
625                 630                 635                 640 


Gly Asp Gln Val Phe Ala Gly Arg Tyr Tyr Ser Ser Glu Asn Thr Arg 
                645                 650                 655     


Pro Lys Phe Leu Ser Arg Asp Val Asp Ser Glu Ile Ser Asp Leu Glu 
            660                 665                 670         


Asn Glu Val Glu Asn Lys Thr Ala Gln Ile Leu Asn Leu Gln Gln His 
        675                 680                 685             


Leu Ser Ala Leu Glu Lys Asp Ile Lys His Asn Glu Glu Leu Leu Lys 
    690                 695                 700                 


Arg Cys Gln Leu His Tyr Lys Glu Leu Lys Met Lys Ile Arg Lys Asn 
705                 710                 715                 720 


Ile Ser Glu Ile Arg Glu Leu Glu Asn Ile Glu Glu His Gln Ser Val 
                725                 730                 735     


Asp Ile Ala Thr Leu Glu Asp Glu Ala Gln Glu Asn Lys Ser Lys Met 
            740                 745                 750         


Lys Met Val Glu Glu His Met Glu Gln Gln Lys Glu Asn Met Glu His 
        755                 760                 765             


Leu Lys Ser Leu Lys Ile Glu Ala Glu Asn Lys Tyr Asp Ala Ile Lys 
    770                 775                 780                 


Phe Lys Ile Asn Gln Leu Ser Glu Leu Ala Asp Pro Leu Lys Asp Glu 
785                 790                 795                 800 


Leu Asn Leu Ala Asp Ser Glu Val Asp Asn Gln Lys Arg Gly Lys Arg 
                805                 810                 815     


His Tyr Glu Glu Lys Gln Lys Glu His Leu Asp Thr Leu Asn Lys Lys 
            820                 825                 830         


Lys Arg Glu Leu Asp Met Lys Glu Lys Glu Leu Glu Glu Lys Met Ser 
        835                 840                 845             


Gln Ala Arg Gln Ile Cys Pro Glu Arg Ile Glu Val Glu Lys Ser Ala 
    850                 855                 860                 


Ser Ile Leu Asp Lys Glu Ile Asn Arg Leu Arg Gln Lys Ile Gln Ala 
865                 870                 875                 880 


Glu His Ala Ser His Gly Asp Arg Glu Glu Ile Met Arg Gln Tyr Gln 
                885                 890                 895     


Glu Ala Arg Glu Thr Tyr Leu Asp Leu Asp Ser Lys Val Arg Thr Leu 
            900                 905                 910         


Lys Lys Phe Ile Lys Leu Leu Gly Glu Ile Met Glu His Arg Phe Lys 
        915                 920                 925             


Thr Tyr Gln Gln Phe Arg Arg Cys Leu Thr Leu Arg Cys Lys Leu Tyr 
    930                 935                 940                 


Phe Asp Asn Leu Leu Ser Gln Arg Ala Tyr Cys Gly Lys Met Asn Phe 
945                 950                 955                 960 


Asp His Lys Asn Glu Thr Leu Ser Ile Ser Val Gln Pro Gly Glu Gly 
                965                 970                 975     


Asn Lys Ala Ala Phe Asn Asp Met Arg Ala Leu Ser Gly Gly Glu Arg 
            980                 985                 990         


Ser Phe Ser Thr Val Cys Phe Ile  Leu Ser Leu Trp Ser  Ile Ala Glu 
        995                 1000                 1005             


Ser Pro  Phe Arg Cys Leu Asp  Glu Phe Asp Val Tyr  Met Asp Met 
    1010                 1015                 1020             


Val Asn  Arg Arg Ile Ala Met  Asp Leu Ile Leu Lys  Met Ala Asp 
    1025                 1030                 1035             


Ser Gln  Arg Phe Arg Gln Phe  Ile Leu Leu Thr Pro  Gln Ser Met 
    1040                 1045                 1050             


Ser Ser  Leu Pro Ser Ser Lys  Leu Ile Arg Ile Leu  Arg Met Ser 
    1055                 1060                 1065             


Asp Pro  Glu Arg Gly Gln Thr  Thr Leu Pro Phe Arg  Pro Val Thr 
    1070                 1075                 1080             


Gln Glu  Glu Asp Asp Asp Gln  Arg 
    1085                 1090     


<210>  485
<211>  2533
<212>  DNA
<213>  Homo Sapiens

<400>  485
attcttctat tagataacag tagctattta aatacttctg cagaagctca catattttta       60

gtttgttgaa gttcgtgact gcttcactct ctcattctta gcttgaattt ggaaatgact      120

tttgatgacc taaagatcca gactgtgaag gaccagcctg atgagaagtc aaatggaaaa      180

aaagctaaag gtcttcagtt tctttactct ccatggtggt gcctggctgc tgcgactcta      240

ggggtccttt gcctgggatt agtagtgacc attatggtgc tgggcatgca attatcccag      300

gtgtctgacc tcctaacaca agagcaagca aacctaactc accagaaaaa gaaactggag      360

ggacagatct cagcccggca acaagcagaa gaagcttcac aggagtcaga aaacgaactc      420

aaggaaatga tagaaaccct tgctcggaag ctgaatgaga aatccaaaga gcaaatggaa      480

cttcaccacc agaatctgaa tctccaagaa acactgaaga gagtagcaaa ttgttcagct      540

ccttgtccgc aagactggat ctggcatgga gaaaactgtt acctattttc ctcgggctca      600

tttaactggg aaaagagcca agagaagtgc ttgtctttgg atgccaagtt gctgaaaatt      660

aatagcacag ctgatctgga cttcatccag caagcaattt cctattccag ttttccattc      720

tggatggggc tgtctcggag gaaccccagc tacccatggc tctgggagga cggttctcct      780

ttgatgcccc acttatttag agtccgaggc gctgtctccc agacataccc ttcaggtacc      840

tgtgcatata tacaacgagg agctgtttat gcggaaaact gcattttagc tgccttcagt      900

atatgtcaga agaaggcaaa cctaagagca cagtgaattt gaaggctctg gaagaaaaga      960

aaaaagtctt tgagttttat tctggaattt aagctattct ttgtcacttg ggtgccaaac     1020

atgagagccc agaaaactgt catttagctg gctgcagaac tcctttgcag aaactggggt     1080

tccaggtgcc tggcaccttt atgtcaacat ttttgattct agctacctgt attatttcac     1140

ctagcttgtc ccaagcttcc ctgccagcct gaagtccatt ttcccctttt tattttaaaa     1200

tttgactcct cttcaagctt gaaaaccctc tgaactcagt cttctttacc tcattatcac     1260

cttcccctca cactcctaaa attgcatgaa agacagaaca tggagaactt gctcaagtgc     1320

aggcagagag caaaaagggg aaatatgtct gggaaaaagt gcacgtgaag aaacaaagaa     1380

ggacagaggc cattccgaaa tcaagaaact catgttctta actttaaaaa aggtatcaat     1440

ccttggtttt taaactgtgg tccatctcca gactctacca cttacggaca gacagacaga     1500

cagacacaca cacacacaca cacacacatt ttgggacaag tggggagccc aagaaagtaa     1560

ttagtaagtg agtggtcttt tctgtaagct aatccacaac ctgttaccac ttcctgaatc     1620

agttattatt tcttcatttt tttttctacc agaggacaga ttaatagatt taacccttca     1680

caacagttct tgttagaatc atgggatgtg tggcccagag gtaagaatag aatttctttc     1740

cctaaagaac ataccttttg tagatgaact cttctcaact ctgttttgct atgctataat     1800

tccgaaacat acaagacaaa aaaaatgaag acactcaatc tagaacaaac taagccaggt     1860

atgcaaatat cgctgaatag aaacagatgg aattagaaat atatcttcta tttttaggct     1920

tctatttcct ttccacccac tcttcacagg ctattctact ttaaaggaag cctttttatt     1980

ttgctgcaca caatctagca ggaatctttt ttttttttta agagctgtgt catccttatg     2040

taggcaagag atgtttgctt ttgttaaaag ctttattgag atataattaa cataaaataa     2100

actgaacata tttaaagtgt actatttgat aagttttcac accttgtgga gaacatgcat     2160

actacaatta agagagtgaa catatccatc atccctcaaa gtgtcacaat gctcctcctg     2220

atgactcctc cccagaaaac caccaatcgg ctttcatttt gcattttgta gttttatgtg     2280

aatggaatca tatagtatgt cttttttttt tgtctggctt ctttcacttt gcataattat     2340

tttgagattc atatgtctcc atcttgatgc tcgtatgaat tcattctttt aaatgttgaa     2400

tattcccttg tatggatata ccacaattca tttacccatt tacttgttga tgacatttgg     2460

gttgttttag ttttgggata ttacaaataa agctgctgtg aacatttgtg tacaagaaaa     2520

aaaaaaaaaa aaa                                                        2533


<210>  486
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  486

Met Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp 
1               5                   10                  15      


Glu Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser 
            20                  25                  30          


Pro Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly 
        35                  40                  45              


Leu Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser 
    50                  55                  60                  


Asp Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys 
65                  70                  75                  80  


Leu Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln 
                85                  90                  95      


Glu Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys 
            100                 105                 110         


Leu Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu 
        115                 120                 125             


Asn Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys 
    130                 135                 140                 


Pro Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser 
145                 150                 155                 160 


Gly Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp 
                165                 170                 175     


Ala Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln 
            180                 185                 190         


Gln Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg 
        195                 200                 205             


Arg Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met 
    210                 215                 220                 


Pro His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser 
225                 230                 235                 240 


Gly Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys 
                245                 250                 255     


Ile Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala 
            260                 265                 270         


Gln 
    


<210>  487
<211>  3198
<212>  DNA
<213>  Homo Sapiens

<400>  487
aggagcacag ctgtgtttgg ctgcagggcc aagagcgctg tcaagaagac ccacacgccc       60

ccctccagca gctgaattcc tgcagctcag cagccgccgc cagagcagga cgaaccgcca      120

atcgcaaggc acctctgaga acttcaggat gcagatgtct ccagccctca cctgcctagt      180

cctgggcctg gcccttgtct ttggtgaagg gtctgctgtg caccatcccc catcctacgt      240

ggcccacctg gcctcagact tcggggtgag ggtgtttcag caggtggcgc aggcctccaa      300

ggaccgcaac gtggttttct caccctatgg ggtggcctcg gtgttggcca tgctccagct      360

gacaacagga ggagaaaccc agcagcagat tcaagcagct atgggattca agattgatga      420

caagggcatg gcccccgccc tccggcatct gtacaaggag ctcatggggc catggaacaa      480

ggatgagatc agcaccacag acgcgatctt cgtccagcgg gatctgaagc tggtccaggg      540

cttcatgccc cacttcttca ggctgttccg gagcacggtc aagcaagtgg acttttcaga      600

ggtggagaga gccagattca tcatcaatga ctgggtgaag acacacacaa aaggtatgat      660

cagcaacttg cttgggaaag gagccgtgga ccagctgaca cggctggtgc tggtgaatgc      720

cctctacttc aacggccagt ggaagactcc cttccccgac tccagcaccc accgccgcct      780

cttccacaaa tcagacggca gcactgtctc tgtgcccatg atggctcaga ccaacaagtt      840

caactatact gagttcacca cgcccgatgg ccattactac gacatcctgg aactgcccta      900

ccacggggac accctcagca tgttcattgc tgccccttat gaaaaagagg tgcctctctc      960

tgccctcacc aacattctga gtgcccagct catcagccac tggaaaggca acatgaccag     1020

gctgccccgc ctcctggttc tgcccaagtt ctccctggag actgaagtcg acctcaggaa     1080

gcccctagag aacctgggaa tgaccgacat gttcagacag tttcaggctg acttcacgag     1140

tctttcagac caagagcctc tccacgtcgc gcaggcgctg cagaaagtga agatcgaggt     1200

gaacgagagt ggcacggtgg cctcctcatc cacagctgtc atagtctcag cccgcatggc     1260

ccccgaggag atcatcatgg acagaccctt cctctttgtg gtccggcaca accccacagg     1320

aacagtcctt ttcatgggcc aagtgatgga accctgaccc tggggaaaga cgccttcatc     1380

tgggacaaaa ctggagatgc atcgggaaag aagaaactcc gaagaaaaga attttagtgt     1440

taatgactct ttctgaagga agagaagaca tttgcctttt gttaaaagat ggtaaaccag     1500

atctgtctcc aagaccttgg cctctccttg gaggaccttt aggtcaaact ccctagtctc     1560

cacctgagac cctgggagag aagtttgaag cacaactccc ttaaggtctc caaaccagac     1620

ggtgacgcct gcgggaccat ctggggcacc tgcttccacc cgtctctctg cccactcggg     1680

tctgcagacc tggttcccac tgaggccctt tgcaggatgg aactacgggg cttacaggag     1740

cttttgtgtg cctggtagaa actatttctg ttccagtcac attgccatca ctcttgtact     1800

gcctgccacc gcggaggagg ctggtgacag gccaaaggcc agtggaagaa acaccctttc     1860

atctcagagt ccactgtggc actggccacc cctccccagt acaggggtgc tgcaggtggc     1920

agagtgaatg tcccccatca tgtggcccaa ctctcctggc ctggccatct ccctccccag     1980

aaacagtgtg catgggttat tttggagtgt aggtgacttg tttactcatt gaagcagatt     2040

tctgcttcct tttattttta taggaataga ggaagaaatg tcagatgcgt gcccagctct     2100

tcacccccca atctcttggt ggggaggggt gtacctaaat atttatcata tccttgccct     2160

tgagtgcttg ttagagagaa agagaactac taaggaaaat aatattattt aaactcgctc     2220

ctagtgtttc tttgtggtct gtgtcaccgt atctcaggaa gtccagccac ttgactggca     2280

cacacccctc cggacatcca gcgtgacgga gcccacactg ccaccttgtg gccgcctgag     2340

accctcgcgc cccccgcgcc cctctttttc cccttgatgg aaattgacca tacaatttca     2400

tcctccttca ggggatcaaa aggacggagt ggggggacag agactcagat gaggacagag     2460

tggtttccaa tgtgttcaat agatttagga gcagaaatgc aaggggctgc atgacctacc     2520

aggacagaac tttccccaat tacagggtga ctcacagccg cattggtgac tcacttcaat     2580

gtgtcatttc cggctgctgt gtgtgagcag tggacacgtg aggggggggt gggtgagaga     2640

gacaggcagc tcggattcaa ctaccttaga taatatttct gaaaacctac cagccagagg     2700

gtagggcaca aagatggatg taatgcactt tgggaggcca aggcgggagg attgcttgag     2760

cccaggagtt caagaccagc ctgggcaaca taccaagacc cccgtctctt taaaaatata     2820

tatattttaa atatacttaa atatatattt ctaatatctt taaatatata tatatatttt     2880

aaagaccaat ttatgggaga attgcacaca gatgtgaaat gaatgtaatc taatagaagc     2940

ctaatcagcc caccatgttc tccactgaaa aatcctcttt ctttggggtt tttctttctt     3000

tcttttttga ttttgcactg gacggtgacg tcagccatgt acaggatcca caggggtggt     3060

gtcaaatgct attgaaattg tgttgaattg tatgcttttt cacttttgat aaataaacat     3120

gtaaaaatgt ttcaaaaaaa taataaaata aataaatacg aagaatatgt caggacagtc     3180

aaaaaaaaaa aaaaaaaa                                                   3198


<210>  488
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  488

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  489
<211>  2513
<212>  DNA
<213>  Homo Sapiens

<400>  489
aaaagtcggt gcccactcgc tccgcgctgc cgcggcaacc agcacacccc ggcacctcct       60

ctgcggcagc tgcgcctcgc aagcgcagtg ccgcagcgca cgccggagtg gctgtagctg      120

cccggcgcgg cgccgccctg cgcgggctgt gggctgcggg ctgcgccccc gctgctggcc      180

agctctgcac ggctgcgggc tctgcggcgc ccggtgctct gcaacgctgc ggcgggcggc      240

atgggataac gcggccatgg tgcgccgaga tcgcctccgc aggatgaggg agtggtgggt      300

ccaggtgggg ctgctggccg tgcccctgct tgctgcgtac ctgcacatcc caccccctca      360

gctctcccct gcccttcact catggaagtc ttcaggcaag tttttcactt acaagggact      420

gcgtatcttc taccaagact ctgtgggtgt ggttggaagt ccagagatag ttgtgctttt      480

acacggtttt ccaacatcca gctacgactg gtacaagatt tgggaaggtc tgaccttgag      540

gtttcatcgg gtgattgccc ttgatttctt aggctttggc ttcagtgaca aaccgagacc      600

acatcactat tccatatttg agcaggccag catcgtggaa gcgcttttgc ggcatctggg      660

gctccagaac cgcaggatca accttctttc tcatgactat ggagatattg ttgctcagga      720

gcttctctac aggtacaagc agaatcgatc tggtcggctt accataaaga gtctctgtct      780

gtcaaatgga ggtatctttc ctgagactca ccgtccactc cttctccaaa agctactcaa      840

agatggaggt gtgctgtcac ccatcctcac acgactgatg aacttctttg tattctctcg      900

aggtctcacc ccagtctttg ggccgtatac tcggccctct gagagtgagc tgtgggacat      960

gtgggcaggg atccgcaaca atgacgggaa cttagtcatt gacagtctct tacagtacat     1020

caatcagagg aagaagttca gaaggcgctg ggtgggagct cttgcctctg taactatccc     1080

cattcatttt atctatgggc cattggatcc tgtaaatccc tatccagagt ttttggagct     1140

gtacaggaaa acgctgccgc ggtccacagt gtcgattctg gatgaccaca ttagccacta     1200

tccacagcta gaggatccca tgggcttctt gaatgcatat atgggcttca tcaactcctt     1260

ctgagctgga aagagtagct tccctgtatt acctccccta ctcccttatg tgttgtgtat     1320

tccacttagg aagaaatgcc caaaagaggt cctggccatc aaacataatt ctctcacaaa     1380

gtccacttta ctcaaattgg tgaacagtgt ataggaagaa gccagcagga gctctgacta     1440

aggttgacat aatagtccac ctcccattac tttgatatct gatcaaatgt atagacttgg     1500

ctttgttttt tgtgctatta ggaaattctg atgagcatta ctattcactg atgcagaaag     1560

acgttctttt gcataaaaga ctttttttta acactttgga cttctctgaa atatttagaa     1620

gtgctaattt ctggcccacc cccaacagga attctatagt aaggaggagg agaagggggg     1680

ctccttccct ctcctcgaat gacgttatgg gcacatgcct tttaaaagtt ctttaagcaa     1740

cacagagctg agtcctcttt gtcatacctt tggatttagt gtttcatcag ctgtttttag     1800

ttataaacat tttgttaaaa tagatattgg tttaaatgat acagtatttt aggtatgatt     1860

taagactatg atttacctat acattatata tattttataa agatactaaa ccagcatacc     1920

cttactctgc cagagtagtg aagctaatta aacacatttg gtttctgaat aaattgaact     1980

aaatccaaac tatttcctaa aatcacagga cattaaggac caatagcatc tgtgccagag     2040

atgtactgtt attagctggg aagaccaatt ctaacagcaa ataacagtct gagactcctc     2100

atacctcagt ggttagaagc atgtctctct tgagctacag tagaggggaa gggattgttg     2160

tgtagtcaag tcaccatgct gaatgtacac tgattccttt atgatgactg cttaactccc     2220

cactgcctgt cccagagagg ctttccaatg tagctcagta attcctgtta ctttacagac     2280

aggaaagttc cagaaacttt aagaacaaac tctgaaagac ctatgagcaa atggtgctga     2340

atactttttt tttaaagcca catttcattg tcttagtcaa agcaggatta ttaagtgatt     2400

atttaaaatt cgttttttta aattagcaac ttcaagtata acaactttga aactggaata     2460

agtgtttatt ttctattaat aaaaatgaat tgtgacaaaa gtggaaaaaa aaa            2513


<210>  490
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  490

Met Val Arg Arg Asp Arg Leu Arg Arg Met Arg Glu Trp Trp Val Gln 
1               5                   10                  15      


Val Gly Leu Leu Ala Val Pro Leu Leu Ala Ala Tyr Leu His Ile Pro 
            20                  25                  30          


Pro Pro Gln Leu Ser Pro Ala Leu His Ser Trp Lys Ser Ser Gly Lys 
        35                  40                  45              


Phe Phe Thr Tyr Lys Gly Leu Arg Ile Phe Tyr Gln Asp Ser Val Gly 
    50                  55                  60                  


Val Val Gly Ser Pro Glu Ile Val Val Leu Leu His Gly Phe Pro Thr 
65                  70                  75                  80  


Ser Ser Tyr Asp Trp Tyr Lys Ile Trp Glu Gly Leu Thr Leu Arg Phe 
                85                  90                  95      


His Arg Val Ile Ala Leu Asp Phe Leu Gly Phe Gly Phe Ser Asp Lys 
            100                 105                 110         


Pro Arg Pro His His Tyr Ser Ile Phe Glu Gln Ala Ser Ile Val Glu 
        115                 120                 125             


Ala Leu Leu Arg His Leu Gly Leu Gln Asn Arg Arg Ile Asn Leu Leu 
    130                 135                 140                 


Ser His Asp Tyr Gly Asp Ile Val Ala Gln Glu Leu Leu Tyr Arg Tyr 
145                 150                 155                 160 


Lys Gln Asn Arg Ser Gly Arg Leu Thr Ile Lys Ser Leu Cys Leu Ser 
                165                 170                 175     


Asn Gly Gly Ile Phe Pro Glu Thr His Arg Pro Leu Leu Leu Gln Lys 
            180                 185                 190         


Leu Leu Lys Asp Gly Gly Val Leu Ser Pro Ile Leu Thr Arg Leu Met 
        195                 200                 205             


Asn Phe Phe Val Phe Ser Arg Gly Leu Thr Pro Val Phe Gly Pro Tyr 
    210                 215                 220                 


Thr Arg Pro Ser Glu Ser Glu Leu Trp Asp Met Trp Ala Gly Ile Arg 
225                 230                 235                 240 


Asn Asn Asp Gly Asn Leu Val Ile Asp Ser Leu Leu Gln Tyr Ile Asn 
                245                 250                 255     


Gln Arg Lys Lys Phe Arg Arg Arg Trp Val Gly Ala Leu Ala Ser Val 
            260                 265                 270         


Thr Ile Pro Ile His Phe Ile Tyr Gly Pro Leu Asp Pro Val Asn Pro 
        275                 280                 285             


Tyr Pro Glu Phe Leu Glu Leu Tyr Arg Lys Thr Leu Pro Arg Ser Thr 
    290                 295                 300                 


Val Ser Ile Leu Asp Asp His Ile Ser His Tyr Pro Gln Leu Glu Asp 
305                 310                 315                 320 


Pro Met Gly Phe Leu Asn Ala Tyr Met Gly Phe Ile Asn Ser Phe 
                325                 330                 335 


<210>  491
<211>  6936
<212>  DNA
<213>  Homo Sapiens

<400>  491
aggccgcgct cagcaggcgg ggcgggagcc gcgtgcgccc gaggacccgg ccggaaggct       60

tgcgccagct caggatgagg acaggctggg cgacccctcg ccgcccggcg gggctcctca      120

tgctgctctt ctggttcttc gatctcgcgg agccctctgg ccgcgcagct aatgacccct      180

tcaccatcgt ccatggaaat acgggcaagt gcatcaagcc agtgtatggc tggatagtag      240

cagacgactg tgatgaaact gaggacaagt tatggaagtg ggtgtcccag catcggctct      300

ttcatttgca ctcccaaaag tgccttggcc tcgatattac caaatcggta aatgagctga      360

gaatgttcag ctgtgactcc agtgccatgc tgtggtggaa atgtgagcac cactctctgt      420

acggagctgc ccggtaccgg ctggctctga aggatggaca tggcacagca atctcaaatg      480

catctgatgt ctggaagaaa ggaggctcag aggaaagcct ttgtgaccag ccttatcatg      540

agatctatac cagagatggg aactcttatg ggagaccttg tgaatttcca ttcttaattg      600

atgggacctg gcatcatgat tgcattcttg atgaagatca tagtgggcca tggtgtgcca      660

ccaccttaaa ttatgaatat gaccgaaagt ggggcatctg cttaaagcct gaaaacggtt      720

gtgaagataa ttgggaaaag aacgagcagt ttggaagttg ctaccaattt aatactcaga      780

cggctctttc ttggaaagaa gcttatgttt catgtcagaa tcaaggagct gatttactga      840

gcatcaacag tgctgctgaa ttaacttacc ttaaagaaaa agaaggcatt gctaagattt      900

tctggattgg tttaaatcag ctatactctg ctagaggctg ggaatggtca gaccacaaac      960

cattaaactt tctcaactgg gatccagaca ggcccagtgc acctactata ggtggctcca     1020

gctgtgcaag aatggatgct gagtctggtc tgtggcagag cttttcctgt gaagctcaac     1080

tgccctatgt ctgcaggaaa ccattaaata atacagtgga gttaacagat gtctggacat     1140

actcagatac ccgctgtgat gcaggctggc tgccaaataa tggattttgc tatctgctgg     1200

taaatgaaag taattcctgg gataaggcac atgcgaaatg caaagccttc agtagtgacc     1260

taatcagcat tcattctcta gcagatgtgg aggtggttgt cacaaaactc cataatgagg     1320

atatcaaaga agaagtgtgg ataggcctta agaacataaa cataccaact ttatttcagt     1380

ggtcagatgg tactgaagtt actctaacat attgggatga gaatgagcca aatgttccct     1440

acaataagac gcccaactgt gtttcctact taggagagct aggtcagtgg aaagtccaat     1500

catgtgagga gaaactaaaa tatgtatgca agagaaaggg agaaaaactg aatgacgcaa     1560

gttctgataa gatgtgtcct ccagatgagg gctggaagag acatggagaa acctgttaca     1620

agatttatga ggatgaggtc ccttttggaa caaactgcaa tctgactatc actagcagat     1680

ttgagcaaga atacctaaat gatttgatga aaaagtatga taaatctcta agaaaatact     1740

tctggactgg cctgagagat gtagattctt gtggagagta taactgggca actgttggtg     1800

gaagaaggcg ggctgtaacc ttttccaact ggaattttct tgagccagct tccccgggcg     1860

gctgcgtggc tatgtctact ggaaagtctg ttggaaagtg ggaggtgaag gactgcagaa     1920

gcttcaaagc actttcaatt tgcaagaaaa tgagtggacc ccttgggcct gaagaagcat     1980

cccctaagcc tgatgacccc tgtcctgaag gctggcagag tttccccgca agtctttctt     2040

gttataaggt attccatgca gaaagaattg taagaaagag gaactgggaa gaagctgaac     2100

gattctgcca agcccttgga gcacaccttt ctagcttcag ccatgtggat gaaataaagg     2160

aatttcttca ctttttaacg gaccagttca gtggccagca ttggctgtgg attggtttga     2220

ataaaaggag cccagattta caaggatcct ggcaatggag tgatcgtaca ccagtgtcta     2280

ctattatcat gccaaatgag tttcagcagg attatgacat cagagactgt gctgctgtca     2340

aggtatttca taggccatgg cgaagaggct ggcatttcta tgatgataga gaatttattt     2400

atttgaggcc ttttgcttgt gatacaaaac ttgaatgggt gtgccaaatt ccaaaaggcc     2460

gtactccaaa aacaccagac tggtacaatc cagaccgtgc tggaattcat ggacctccac     2520

ttataattga aggaagtgaa tattggtttg ttgctgatct tcacctaaac tatgaagaag     2580

ccgtcctgta ctgtgccagc aatcacagct ttcttgcaac tataacatct tttgtgggac     2640

taaaagccat caaaaacaaa atagcaaata tatctggtga tggacagaag tggtggataa     2700

gaattagcga gtggccaata gatgatcatt ttacatactc acgatatcca tggcaccgct     2760

ttcctgtgac atttggagag gaatgcttgt acatgtctgc caagacttgg cttatcgact     2820

taggtaaacc aacagactgt agtaccaagt tgcccttcat ctgtgaaaaa tataatgttt     2880

cttcgttaga gaaatacagc ccagattctg cagctaaagt gcaatgttct gagcaatgga     2940

ttccttttca gaataagtgt tttctaaaga tcaaacccgt gtctctcaca ttttctcaag     3000

caagcgatac ctgtcactcc tatggtggca cccttccttc agtgttgagc cagattgaac     3060

aagactttat tacatccttg cttccggata tggaagctac tttatggatt ggtttgcgct     3120

ggactgccta tgaaaagata aacaaatgga cagataacag agagctgacg tacagtaact     3180

ttcacccatt attggttagt gggaggctga gaataccaga aaattttttt gaggaagagt     3240

ctcgctacca ctgtgcccta atactcaacc tccaaaaatc accgtttact gggacgtgga     3300

attttacatc ctgcagtgaa cgccactttg tgtctctctg tcagaaatat tcagaagtta     3360

aaagcagaca gacgttgcag aatgcttcag aaactgtaaa gtatctaaat aatctgtaca     3420

aaataatccc aaagactctg acttggcaca gtgctaaaag ggagtgtctg aaaagtaaca     3480

tgcagctggt gagcatcacg gacccttacc agcaggcatt cctcagtgtg caggcgctcc     3540

ttcacaactc ttccttatgg atcggactct tcagtcaaga tgatgaactc aactttggtt     3600

ggtcagatgg gaaacgtctt cattttagtc gctgggctga aactaatggg caactcgaag     3660

actgtgtagt attagacact gatggattct ggaaaacagt tgattgcaat gacaatcaac     3720

caggtgctat ttgctactat tcaggaaatg agactgaaaa agaggtcaaa ccagttgaca     3780

gtgttaaatg tccatctcct gttctaaata ctccgtggat accatttcag aactgttgct     3840

acaatttcat aataacaaag aataggcata tggcaacaac acaggatgaa gttcatacta     3900

aatgccagaa actgaatcca aaatcacata ttctgagtat tcgagatgaa aaggagaata     3960

actttgttct tgagcaactg ctgtacttca attatatggc ttcatgggtc atgttaggaa     4020

taacttatag aaataagtct cttatgtggt ttgataagac cccactgtca tatacacatt     4080

ggagagcagg aagaccaact ataaaaaatg agaagttttt ggctggttta agtactgacg     4140

gcttctggga tattcaaacc tttaaagtta ttgaagaagc agtttatttt caccagcaca     4200

gcattcttgc ttgtaaaatt gaaatggttg actacaaaga agaatataat actacactgc     4260

cacagtttat gccatatgaa gatggtattt acagtgttat tcaaaaaaag gtaacatggt     4320

atgaagcatt aaacatgtgt tctcaaagtg gaggtcactt ggcaagcgtt cacaaccaaa     4380

atggccagct ctttctggaa gatattgtaa aacgtgatgg atttccacta tgggttgggc     4440

tctcaagtca tgatggaagt gaatcaagtt ttgaatggtc tgatggtagt acatttgact     4500

atatcccatg gaaaggccaa acatctcctg gaaattgtgt tctcttggat ccaaaaggaa     4560

cttggaaaca tgaaaaatgc aactctgtta aggatggtgc tatttgttat aaacctacaa     4620

aatctaaaaa gctgtcccgt cttacatatt catcaagatg tccagcagca aaagagaatg     4680

ggtcacggtg gatccagtac aagggtcact gttacaagtc tgatcaggca ttgcacagtt     4740

tttcagaggc caaaaaattg tgttcaaaac atgatcactc tgcaactatc gtttccataa     4800

aagatgaaga tgagaataaa tttgtgagca gactgatgag ggaaaataat aacattacca     4860

tgagagtttg gcttggatta tctcaacatt ctgttgacca gtcttggagt tggttagatg     4920

gatcagaagt gacatttgtc aaatgggaaa ataaaagtaa gagtggtgtt ggaagatgta     4980

gcatgttgat agcttcaaat gaaacttgga aaaaagttga atgtgaacat ggttttggaa     5040

gagttgtctg caaagtgcct ctgggccctg attacacagc aatagctatc atagttgcca     5100

cactaagtat cttagttctc atgggcggac tgatttggtt cctcttccaa aggcaccgtt     5160

tgcacctggc gggtttctca tcagttcgat atgcacaagg agtgaatgaa gatgagatta     5220

tgcttccttc tttccatgac taaattcttc taaaagtttt ctaatttgca ctaatgtgtt     5280

atgagaaatt agtcacttaa aatgtcccag tgtcagtatt tactctgctc caaagtagaa     5340

ctcttaaata ctttttcagt tgtttagatc ttaggcatgt gctggtatcc acagttaatt     5400

ccctgctaaa tgccatgttt atcaccctaa ttaatagaat ggaggggact ccaaagctgg     5460

aactgaagtc caaattgttt gtacagtaat atgtttaatg ttcattttct ctgtatgaat     5520

gtgattggta actaggatat gtatatttta atagaatttt taacaaaact tcttagaaaa     5580

ttaaaatagg catattacta ggtgacatgt ctacttttta atttttaaga gcatccggcc     5640

aaatgcaaaa ttagtacctc aaagtaaaaa ttgaactgta aactctatca gcattgtttc     5700

aaaatagtca tttttagcac tggggaaaaa taaacaataa gacatgctta ctttttaatt     5760

tttatttttt tgagactgag tctctctctg ttgcccaggc tggagtacaa tggcgtgatc     5820

tcggctcact gcaaatctcc gcctcccagg ttcaagcgat tctcctgcct cagcctcctg     5880

agtagctggg attacaggca actgccacca tgcccggcta atttttgtat ttttagtaga     5940

gatggggttt caccatgttg gccaggctgg tctcgaactc gtgaccgcag gtgatcctcc     6000

cgcctcggcc tcccaaagtg ctgggattac aggcatgagc caccgcgcct ggcctctgct     6060

tactttttat atagcaaaat gattcctctt ggcaagatgt ttcttatatt attccaaagt     6120

tatttcatac cattattatg taaatatgaa gagttttttt ctgtttataa ttgtttataa     6180

aacaatgact tttaaagatt tagtgcttaa cattttccca agtgtgggaa cattattttt     6240

agattgagta ggtaccttgt agcagtgtgc tttgcatttt ctgatgtatt acatgactgt     6300

ttcttttgta aagagaatca actaggtatt taagactgat aattttacaa tttatatgct     6360

tcacatagca tgtcaacttt tgactaagaa ttttgtttta cttttttaac atgtgttaaa     6420

cagagaaagg gtccatgaag gaaagtgtat gagttgcatt tgtaaaaatg agactttttc     6480

agtggaactc taaaccttgt gatgactact aacaaatgta aaattatgag tgattaagaa     6540

aacattgctt tgtggttatc actttaagtt ttgacaccta gattatagtc ttagtaatag     6600

catccactgg aaaaggtgaa aatgttttat tcggcattta acttacattt gtactttatt     6660

tttgtataaa atccatagat ttattttaca tttagagtat ttacactatg ataaagttgt     6720

aaataatttt ctaagacagt ttttatatag tctacagttg tcctgatttc ttattgaatt     6780

tgttagacta gttctcttgt cctgtgatct gtgtacaatt ttagtcacta agactttcct     6840

ccaagaacta agccaacttg atgtgaaaag cacagctgta tataatggtg atgtcataat     6900

aaagttgttt tatcttttaa gtaaaagtaa aaaaaa                               6936


<210>  492
<211>  1722
<212>  PRT
<213>  Homo Sapiens

<400>  492

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  493
<211>  3678
<212>  DNA
<213>  Homo Sapiens

<400>  493
gacgcgcgcc gggagccgcg ggccgggcca gccgggccgc cggggcccag tgcgccgcgc       60

tcgcagccgg tagcgcgcca gcgccgtagg cgctcgctcg gcagccgcgg ggccctaggc      120

cgtgccgggg agggggcgag ggcggcgccc aggcgcctgc cgccccggag gcaggatgag      180

catcgagatc ccggcgggac tgacggagct gctgcagggc ttcacggtgg aggtgctgag      240

gcaccagccc gcggacctgc tggagttcgc gctgcagcac ttcacccgcc tgcagcagga      300

gaacgagcgc aaaggcaccg cgcgcttcgg ccatgagggc aggacctggg gggacctggg      360

cgccgctgcc gggggcggca cccccagcaa gggggtcaac ttcgccgagg agcccatgca      420

gtccgactcc gaggacgggg aggaggagga ggcggcgccc gcggacgcag gggcgttcaa      480

tgctccagta ataaaccgat tcacaaggcg tgcctcagta tgtgcagaag cttataatcc      540

tgatgaagaa gaagatgatg cagagtccag gattatacat ccaaaaactg atgatcaaag      600

aaataggttg caagaggctt gcaaagacat cctgctgttt aagaatctgg atccggagca      660

gatgtctcaa gtattagatg ccatgtttga aaaattggtc aaagatgggg agcatgtaat      720

tgatcaaggt gacgatggtg acaactttta tgtaattgat agaggcacat ttgatattta      780

tgtgaaatgt gatggtgttg gaagatgtgt tggtaactat gataatcgtg ggagtttcgg      840

cgaactggcc ttaatgtaca atacacccag agcagctaca atcactgcta cctctcctgg      900

tgctctgtgg ggtttggaca gggtaacctt caggagaata attgtgaaaa acaatgccaa      960

aaagagaaaa atgtatgaaa gctttattga gtcactgcca ttccttaaat ctttggagtt     1020

ttctgaacgc ctgaaagtag tagatgtgat aggcaccaaa gtatacaacg atggagaaca     1080

aatcattgct cagggagatt cggctgattc ttttttcatt gtagaatctg gagaagtgaa     1140

aattactatg aaaagaaagg gtaaatcaga agtggaagag aatggtgcag tagaaatcgc     1200

tcgatgctcg cggggacagt actttggaga gcttgccctg gtaactaaca aacctcgagc     1260

agcttctgcc cacgccattg ggactgtcaa atgtttagca atggatgtgc aagcatttga     1320

aaggcttctg ggaccttgca tggaaattat gaaaaggaac atcgctacct atgaagaaca     1380

gttagttgcc ctgtttggaa cgaacatgga tattgttgaa cccactgcat gaagcaaaag     1440

tatggagcaa gacctgtagt gacaaaatta cacagtagtg gttagtccac tgagaatgtg     1500

tttgtgtaga tgccaagcat tttctgtgat ttcaggtttt ttcctttttt tacatttaca     1560

acgtatcaat aaacagtagt gatttaatag tcaataggct ttaacatcac tttctaaaga     1620

gtagttcata aaaaaatcaa catactgata aaatgacttt gtactccaca aaattatgac     1680

tgaaaggttt attaaaatga ttgtaatata tagaaagtat ctgtgtttaa gaagataatt     1740

aaaggatgtt atcataggct atatgtgttt tacttattca gactgataat catattagtg     1800

actatcccca tgtaagaggg cacttggcaa ttaaacatgc tacacagcat ggcatcactt     1860

ttttttataa ctcattaaac acagtaaaat tttaatcatt tttgttttaa agttttctag     1920

cttgataagt tatgtgctgg ccttggccta ttggtgaaat ggtataaaat atcatatgca     1980

gttttaaaac tttttatatt tttgcaataa agtacatttt gactttgttg gcataatgtc     2040

agtaacatac atattccagt ggttttatgg acaggcaatt tagtcattat gataataagg     2100

aaaacagtgt tttagatgag agatcattaa tgcatttttc cctcatcaag catatatctg     2160

ctttttttta ttttgcaatt ctctgtattc tatgtcttta aaaatttgat cttgacattt     2220

aatgtcacaa agttttgttt ttttaaaaag tgatttaaac ttaagatccg acattttttg     2280

tattctttaa gattttacac ctaaaaaatc tctcctatcc caaaaataat gtgggatcct     2340

tatcagcatg cccacagttt atttctttgt tcttcactag gcctgcataa tacagtccta     2400

tgtagacatc tgttcccttg ggtttccgtt ctttcttagg atggttgcca acccacaatc     2460

tcattgatca gcagccaata tgggtttgtt tggttttttt aattcttaaa aacatcctct     2520

agaggaatag aaacaaattt ttatgagcat aaccctatat aaagacaaaa tgaatttctg     2580

accttaccat atataccatt aggccttgcc attgctttaa tgtagactca tagttgaaat     2640

tagtgcagaa agaactcaga tgtactagat tttcattgtt cattgatatg ctcagtatgc     2700

tgccacataa gatgaattta attatattca accaaagcaa tatactctta catgatttct     2760

aggccccatg acccagtgtc tagagacatt aattctaacc agttgtttgc ttttaaatga     2820

gtgatttcat tttgggaaac aggtttcaaa tgaatatata tacatgggta aaattactct     2880

gtgctagtgt agtcttacta gagaatgttt atggtcccac ttgtatatga aaatgtggtt     2940

agaatgttaa ttggataatg tatatataag aagttaaagt atgtaaagta taacttcagc     3000

cacattttta gaacactgtt taacattttt gcaaaacctt cttgtaggaa aagagagctc     3060

tctacatgaa gatgacttgt tttatatttc agattttatt ttaaaagcca tgtctgttaa     3120

acaagaaaaa acacaaaaga actccagatt cctggttcat cattctgtat tcttactcac     3180

tttttcaagt tatctatttt gttgcataaa ctaattgtta actattcatg gaacagcaaa     3240

cgcctgttta ataaagaact ttgaccaagg ctataaatgc cacgtacatt attttcagta     3300

ttgttggtta tatttaaatt ttccttacaa taaagcacac ttttataata aaatacatga     3360

attattgttt ttcatacttt tttgcttgtt tctttaaagt tttctgacgt gcataatgca     3420

taattcattg aaaagcatga tagcaatgtg gcatgtggaa gcgaaccccc agggcataac     3480

atagtaagaa agtatggttc tgtatggcaa taggttttta aaattattag ctattcatca     3540

tgtgtgggag aaataattgt ggtgtgttgc agatttattt ggccatttag aataaccaaa     3600

tcaatctggc taactaggaa tttatgtgta aaattatctg attaaaacag ctcaagtttg     3660

aaaaaaaaaa aaaaaaaa                                                   3678


<210>  494
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  494

Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe 
1               5                   10                  15      


Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala 
            20                  25                  30          


Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr 
        35                  40                  45              


Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala 
    50                  55                  60                  


Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro 
65                  70                  75                  80  


Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala 
                85                  90                  95      


Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg 
            100                 105                 110         


Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp 
        115                 120                 125             


Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg 
    130                 135                 140                 


Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro 
145                 150                 155                 160 


Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys 
                165                 170                 175     


Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
            180                 185                 190         


Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val 
        195                 200                 205             


Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
    210                 215                 220                 


Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser 
225                 230                 235                 240 


Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
                245                 250                 255     


Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu 
            260                 265                 270         


Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val 
        275                 280                 285             


Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile 
    290                 295                 300                 


Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu 
305                 310                 315                 320 


Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn 
                325                 330                 335     


Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu 
            340                 345                 350         


Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile 
        355                 360                 365             


Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu 
    370                 375                 380                 


Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu 
385                 390                 395                 400 


Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro 
                405                 410                 415     


Thr Ala 
        


<210>  495
<211>  4022
<212>  DNA
<213>  Homo Sapiens

<400>  495
aataatctcc gctcccagac tactccgttc ctccggattt cgatccccct ttttctatct       60

gtcaatcagc gccgcctttg aactgaaaag ctctcagtct aacttcaact cactcaaatc      120

cgagcggcac gagcacctcc tgtatcttcg gcttcccccc ccctttgctc tttatatctg      180

acttcttgtt gttgttggtg tttttttttt ttttaccccc cttttttatt tattattttt      240

ttgcacattg atcggatcct tgggaacgag agaaaaaaga aacccaaact cacgcgtgca      300

gaagatctcc ccccccttcc cctcccctcc tccctctttt cccctcccca ggagaaaaag      360

acccccaagc agaaaaaagt tcaccttgga ctcgtctttt tcttgcaata ttttttgggg      420

gggcaaaact ttttgggggt gatttttttt ggcttttctt cctccttcat ttttcttcca      480

aaattgctgc tggtgggtga aaaaaaaatg ccgcagctga acggcggtgg aggggatgac      540

ctaggcgcca acgacgaact gatttccttc aaagacgagg gcgaacagga ggagaagagc      600

tccgaaaact cctcggcaga gagggattta gctgatgtca aatcgtctct agtcaatgaa      660

tcagaaacga atcaaaacag ctcctccgat tccgaggcgg aaagacggcc tccgcctcgc      720

tccgaaagtt tccgagacaa atcccgggaa agtttggaag aagcggccaa gaggcaagat      780

ggagggctct ttaaggggcc accgtatccc ggctacccct tcatcatgat ccccgacctg      840

acgagcccct acctccccaa cggatcgctc tcgcccaccg cccgaaccct ccattttcag      900

tccggcagca cacattactc tgcgtacaaa acgattgaac accagattgc agttcagtat      960

ctccagatga aatggccact gcttgatgtc caggcaggga gcctccagag tagacaagcc     1020

ctcaaggatg cccggtcccc atcaccggca cacattgtct ctaacaaagt gccagtggtg     1080

cagcaccctc accatgtcca ccccctcacg cctcttatca cgtacagcaa tgaacacttc     1140

acgccgggaa acccacctcc acacttacca gccgacgtag accccaaaac aggaatccca     1200

cggcctccgc accctccaga tatatccccg tattacccac tatcgcctgg caccgtagga     1260

caaatccccc atccgctagg atggttagta ccacagcaag gtcaaccagt gtacccaatc     1320

acgacaggag gattcagaca cccctacccc acagctctga ccgtcaatgc ttccatgtcc     1380

aggttccctc cccatatggt cccaccacat catacgctac acacgacggg cattccgcat     1440

ccggccatag tcacaccaac agtcaaacag gaatcgtccc agagtgatgt cggctcactc     1500

catagttcaa agcatcagga ctccaaaaag gaagaagaaa agaagaagcc ccacataaag     1560

aaacctctta atgcattcat gttgtatatg aaggaaatga gagcaaaggt cgtagctgag     1620

tgcacgttga aagaaagcgc ggccatcaac cagatccttg ggcggaggtg gcatgcactg     1680

tccagagaag agcaagcgaa atactacgag ctggcccgga aggagcgaca gcttcatatg     1740

caactgtacc ccggctggtc cgcgcgggat aactatggaa agaagaagaa gaggaaaagg     1800

gacaagcagc cgggagagac caatgatgca aatactccaa agaagtgtcg ggcactgttc     1860

gggcttgacc gacagacttt atggtgcaaa ccgtgcagga gaaaaaaaaa gtgcgttcgc     1920

tacatacaag gtgaaggcag ctgcctcagc ccaccctctt cagatggaag cttactagat     1980

tcgcctcccc cctccccgaa cctgctaggc tcccctcccc gagacgccaa gtcacagact     2040

gagcagaccc agcctctgtc gctgtccctg aagcccgacc ccctggccca cctgtccatg     2100

atgcctccgc cacccgccct cctgctcgct gaggccaccc acaaggcctc cgccctctgt     2160

cccaacgggg ccctggacct gcccccagcc gctttgcagc ctgccgcccc ctcctcatca     2220

attgcacagc cgtcgacttc ttccttacat tcccacagct ccctggccgg gacccagccc     2280

cagccgctgt cgctcgtcac caagtcttta gaatagcttt agcgtcgtga accccgctgc     2340

tttgtttatg gttttgtttc acttttctta atttgccccc cacccccacc ttgaaaggtt     2400

ttgttttgta ctctcttaat tttgtgccat gtggctacat tagttgatgt ttatcgagtt     2460

cattggtcaa tatttgaccc attcttattt caatttctcc ttttaaatat gtagatgaga     2520

gaagaacctc atgattctac caaaattttt atcaacagct gtttaaagtc tttgtagcgt     2580

ttaaaaaata tatatatata cataactgtt atgtagttcg gatagcttag ttttaaaaga     2640

ctgattaaaa aacaaaaaga aaaaaaaagc aattttgaag cagccctcca gaaggagttg     2700

gttctgtatt atttgtatta aatacgagct tgcgaaccaa tcattttaca tctggttttt     2760

aaaccgtaag ggcaccatga atgcagtgcc gttacttttt tttttttttt ctgtgtgaaa     2820

caactcttat tgtgatgtta cttgttattg tttaaatgta cagaaacaaa gggtaaaaat     2880

gtgttaatat accttgttcc atggtgttgt tcttttgggg ggaggggacg ctactcaaca     2940

cttaatagaa tcacaacgct gttgggccag tagtatttat tgctttagag attgcttgtc     3000

gtacctgtat gtcgtccctt tttaaatatg ttttcctttt tcttgaaact gtataaagtt     3060

tttttccccc ttagcataag catcttatat ataacaactc atttgtacaa ggtttttaag     3120

tttatatata aaatgtgtat atatattttt gtttcccctt tttgactttt ttttttctgt     3180

atgaaaccca gatgtcacca aatggacatt aatagttgca ttaaggatca gtagcattaa     3240

caaaagttgc tttaaaagcc attatgtaaa acaagacttg aaaatgagtg agggaatttt     3300

agcgacactg tctgagcagc agtgggaacc atcttcgttt cccctttgaa ctcccagtgg     3360

gatgccctac cctgcgccct taggacccgg actgaccgtg tacaaaactt tacgtgccaa     3420

aattctcagt gaatttagct ttctccctct ttttgatgct gtaatttttg ttcatcatgt     3480

tttgctgtga tgttacatag gtagatttgt atgtagtttt aatgtcacct ataacaaaat     3540

gtgtttggta gcagattgtc cagaaagcat tttaaatgaa gaggtataaa cccttaaggg     3600

ccaaaattct gtatattaga ttactcttaa acgaaaaacc agctgccgct tttatgtaca     3660

catattacat acgagtaggc agcagacttt aaaaataaaa aaaacctagg catgttgatg     3720

ttgcaaaatg ctgtataaag ctgaaacctg ttcattcagt gccattgtag ttgacatgaa     3780

gcgattgtaa aactgtctcc gatttttctc tggtttatta aaatgctaac tataacattt     3840

tttgtgaata ctttgaatgt ttcctaacag ttgtgatgtt actgttccgt tttatgctct     3900

tattccaagt tcatttttaa tggtttggaa gccatttttg taatgaataa atgttcatgc     3960

tgtacagtat ctgtagcatg ccgttctgga ttaataaaag caacttagta tgtgcagata     4020

aa                                                                    4022


<210>  496
<211>  602
<212>  PRT
<213>  Homo Sapiens

<400>  496

Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 
1               5                   10                  15      


Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 
            20                  25                  30          


Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 
        35                  40                  45              


Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 
    50                  55                  60                  


Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 
65                  70                  75                  80  


Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 
                85                  90                  95      


Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 
            100                 105                 110         


Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu 
        115                 120                 125             


His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu 
    130                 135                 140                 


His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg 
                165                 170                 175     


Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln 
            180                 185                 190         


His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn 
        195                 200                 205             


Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val 
    210                 215                 220                 


Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser 
225                 230                 235                 240 


Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro 
                245                 250                 255     


Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr 
            260                 265                 270         


Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala 
        275                 280                 285             


Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu 
    290                 295                 300                 


His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys 
305                 310                 315                 320 


Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His 
                325                 330                 335     


Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys 
            340                 345                 350         


Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val 
        355                 360                 365             


Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu 
    370                 375                 380                 


Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr 
385                 390                 395                 400 


Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly 
                405                 410                 415     


Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp 
            420                 425                 430         


Lys Gln Pro Gly Glu Thr Asn Asp Ala Asn Thr Pro Lys Lys Cys Arg 
        435                 440                 445             


Ala Leu Phe Gly Leu Asp Arg Gln Thr Leu Trp Cys Lys Pro Cys Arg 
    450                 455                 460                 


Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu 
465                 470                 475                 480 


Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser 
                485                 490                 495     


Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu 
            500                 505                 510         


Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala His 
        515                 520                 525             


Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr 
    530                 535                 540                 


His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro 
545                 550                 555                 560 


Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser 
                565                 570                 575     


Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro Gln 
            580                 585                 590         


Pro Leu Ser Leu Val Thr Lys Ser Leu Glu 
        595                 600         


<210>  497
<211>  3524
<212>  DNA
<213>  Homo Sapiens

<400>  497
caggaagagg tatttcttgg ggatgctacc aaggcagaga ctgtgaagaa ggaagaacgt       60

tgcttgggca aaaggagcat attctcagga gacggggccc ctgcctgcca caccaagcat      120

taggccacca ggaagacccc catctgcaag caagcctagc cttccaggga gaaagaggcc      180

cctgcagctc cttcatcatg aactggcaca tgatcatctc tgggcttatt gtggtagtgc      240

ttaaagttgt tggaatgacc ttatttctac tttatttccc acagattttt aacaaaagta      300

acgatggttt caccaccacc aggagctatg gaacagtctc acagattttt gggagcagtt      360

ccccaagtcc caacggcttc attaccacaa ggagctatgg aacagtctgc cccaaagact      420

gggaatttta tcaagcaaga tgttttttct tatccacttc tgaatcatct tggaatgaaa      480

gcagggactt ttgcaaagga aaaggatcca cattggcaat tgtcaacacg ccagagaaac      540

tgaagtttct tcaggacata actgatgctg agaagtattt tattggctta atttaccatc      600

gtgaagagaa aaggtggcgt tggatcaaca actctgtgtt caatggcaat gttaccaatc      660

agaatcagaa tttcaactgt gcgaccattg gcctaacaaa gacatttgat gctgcatcat      720

gtgacatcag ctaccgcagg atctgtgaga agaatgccaa atgatcacag ttccctgtga      780

caagaactat acttgcaact ctttttgaat ccatacaggt cgtctggcca atgattcttt      840

tacttaccta tctgtctacc agtagcggtc cttgcccatt tgggaaactg agcttctttc      900

ttctgcactg ggggactgga tgctagccat ctccaggaga caggatcagt tttacggaaa      960

caactcagtt agtatagaga tgaggtccgc ttctgtagta ctgagcattt ctgactgatc     1020

aaaaaggcct agtctgttga cagggtttgt tttattttag cctcagagta taccatacta     1080

ctagggagta actgtagagt gagaaattat aaacattatt tagggattac catggtggaa     1140

gagggataaa cataggtcct gtgacttcgt ctctgttctc aagggaaccc cattcacatg     1200

cccctcctaa ctccacaagc gagggtagca gaggctctcc tcagtctgaa ctaaggcttg     1260

gccttgggga gggctcctag tgctgagctt ggagcagcac ggacagcagc attgtttatg     1320

ggaatggaga gaggtctggg caggatagga accttcttgg agaccccttt gaagaaaacc     1380

aggcagccaa gggagccaaa cacactagat ttctgttctt cagcaaagcc ctgaagagac     1440

acttaagcta aaaattccct tgtcatattt ctgaaactcc attataacat atgtaactcc     1500

tttgtaacca aaatttaggt aagcaggctt cctttgctct gaaggttttg agtacctggc     1560

tgtatttgtt gagtattttt aaaattttgg atagtctctt aggcaacaat aatcacaata     1620

tattcatccc ttcagttctg gagaaagcct gataccaggc acagcctact gaccccaagg     1680

agcctggcac tgattggcat cacattgatc tagaactggt ccagccgacg aagagtagga     1740

aaagagaagg gctgctcagg gaaacattgg ctgggggcac ggaataagca catagtaaaa     1800

agggaacatc agggtcaaat ggaaatcacc tgagacagga aacagggagt tcatttggcc     1860

acactggaag aaaggcaaga aagaggaaga caagtcttgg agtaccctgg ctgttctcca     1920

cactcacaag acatcagcta tatactctgc ttggtgcata agaaagagaa aagagatgcc     1980

ttttgtgttt tgagtaagaa taattaaacc ataaggaaga ccatgtataa aactgatgga     2040

aataatagtc accaaagtac agcacatacc attttgtgtc taataacaat gtagcacagt     2100

aatgactgta catgtcattg tatgtatacc aaacaagatt gttgtaaatc atatttttta     2160

ttacaacact aagttctgct tctgcattcc taggtttcat catttttggc tccttagcat     2220

ggccacttac aattttttaa catgagataa cacatcaggt gtcagaactt gcttgaaggg     2280

aattaccaga agtaatttgt gtttgagatg gggtggaaat tggaattata ttagtagccg     2340

gtggagatac aagttctctg actgtgttgg gaaaggataa gtgctaccgt tgagaaggga     2400

agaaaggctg agtctaggtg gagaaaaata tcaacagaac tctagccaaa ggcaagcccc     2460

agaactcaga caacagaaag gaaatcctaa tccttctgtt ttgagaagag agaactgtag     2520

ttgcttcact tcctatttca tgacagaata actgcaaact tttaagatca ggaaatgtag     2580

acatctagtg atttctttag tagacagttt aatttccccc aagattagga gacacttctg     2640

tgcaggttct aaaaggagcc caatggcctg gggtgggagt ggggagtaga tagggaatat     2700

gtgggatttg gtttaagttc atcattggaa gagttcctgg atccttgcaa gcttagataa     2760

atgtgatctt tattagatag cagtggcatg ctttaaaaaa aaaaaaggca atgaaaattt     2820

agcaagccac tgaatttgag ttttcacttt gtttctaata tgctgtgtga atcagtacag     2880

ttttcttacc ctttcttggt cttaatttcc ttactgataa aatggggtag taatacctat     2940

ctcaaaaaat tattgcacat attaaataac attcctctat gtatctcaat ggcattagac     3000

attaggagaa gcattttgtg gaggatttga agttgagatc ttcatccaag aagtagcttt     3060

tcaatttgct agaagcttaa tgtaggcaag ccacttcatt tttcagaact tgtttactca     3120

tttataatat gggaataaaa atttgtgcaa gtcagagaag ggtgccttaa aaatgttgtg     3180

gccaagccac atgagatcaa agacacactt ttcatgacct caaatgtggg cccagcctag     3240

gtcagccaac ccccatccaa cccttagact cacgaacaaa tccacctgag atcagcagag     3300

ccaccctaga tcagctgaaa ctctaagcac aaaaataaaa acttatcact gtataccact     3360

ggagttttct ggttatctct cgtatagcaa aatctaactg atgcaatctc catctggcct     3420

tcatccttct ccctttattg tcctttcgtg tattgttcat ccagcaacca ggatgatctt     3480

gttaaaacat taaacagatt ctgtcactct taaaaaaaaa aaaa                      3524


<210>  498
<211>  188
<212>  PRT
<213>  Homo Sapiens

<400>  498

Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Thr Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Thr Thr Thr Arg Ser Tyr Gly Thr Val Ser 
        35                  40                  45              


Gln Ile Phe Gly Ser Ser Ser Pro Ser Pro Asn Gly Phe Ile Thr Thr 
    50                  55                  60                  


Arg Ser Tyr Gly Thr Val Cys Pro Lys Asp Trp Glu Phe Tyr Gln Ala 
65                  70                  75                  80  


Arg Cys Phe Phe Leu Ser Thr Ser Glu Ser Ser Trp Asn Glu Ser Arg 
                85                  90                  95      


Asp Phe Cys Lys Gly Lys Gly Ser Thr Leu Ala Ile Val Asn Thr Pro 
            100                 105                 110         


Glu Lys Leu Lys Phe Leu Gln Asp Ile Thr Asp Ala Glu Lys Tyr Phe 
        115                 120                 125             


Ile Gly Leu Ile Tyr His Arg Glu Glu Lys Arg Trp Arg Trp Ile Asn 
    130                 135                 140                 


Asn Ser Val Phe Asn Gly Asn Val Thr Asn Gln Asn Gln Asn Phe Asn 
145                 150                 155                 160 


Cys Ala Thr Ile Gly Leu Thr Lys Thr Phe Asp Ala Ala Ser Cys Asp 
                165                 170                 175     


Ile Ser Tyr Arg Arg Ile Cys Glu Lys Asn Ala Lys 
            180                 185             


<210>  499
<211>  2124
<212>  DNA
<213>  Homo Sapiens

<400>  499
ggcacaatgc tcttgccctc taagaaggac ctcaagactg ccctggatgt ctttgctgtt       60

ttccagtggt ccttcagtgc cttgcttatc acaaccactg tgattgctgt caacctctac      120

ctggtggtgt tcacaccata ctggcctgtc actgtgctta ttcttacctg gctggctttt      180

gactggaaga cccctcagcg aggcggccgc cggtttacct gtgtgaggca ctggcgcctg      240

tggaaacact acagcgatta tttccctctc aagcttctga agactcatga catctgcccc      300

agccgcaact acatcctcgt ctgccaccct catgggctct ttgcccatgg atggtttggc      360

cactttgcca cagaggcctc aggcttctcc aagatatttc ctggcatcac cccttacata      420

ctcacactgg gagccttttt ctggatgcct ttcctcagag aatatgtaat gtctacaggg      480

gcctgctctg tgagtcgatc ctccattgac tttctgctga ctcataaagg cacaggcaac      540

atggtcattg tggtgattgg tggactggct gagtgcagat acagcctgcc aggttcttct      600

accctggtgt tgaagaaccg gtctggcttt gtgcgcatgg cccttcagca tggggtgcct      660

ctaatacctg cctatgcctt tggggagacg gacctctatg atcagcacat tttcactcct      720

ggtggctttg tcaaccgctt ccagaagtgg ttccagagca tggtacacat ctacccttgt      780

gctttctatg gacgtggctt caccaagaac tcctggggcc ttctgcccta tagtcggcct      840

gtaaccacca tcgtcgggga gcctctacca atgcccaaga ttgagaatcc aagccaggag      900

atcgtggcta aatatcacac actctatatt gatgccctac gtaaactgtt tgaccagcat      960

aagaccaagt ttggtatctc agagacccag gagctggaga taatttgaca gacatcccca     1020

gtagccttca ccctggctgg aagctctttt ctgccctttc tttgcagcta ctggtgagat     1080

agtcccaaga aacagggaag agcctagggg agaggtgccc tgacggcact ttggtgccag     1140

cattgaggaa aacaatggac aaaataaaaa gcccatcttc tgataactgc gtgtgcacca     1200

actactctgt tttgaaggct ctgggatgca tgtctctcct tctctagctg tcaaacagcc     1260

ccatctcccg gcattgagcc ccatcttctg gcattgagtc ctgcttccta caggagtagg     1320

actggggcct tgagagccag tgggctttga gtttaagctc caccaacttc aagccatgtg     1380

actttggggc aatcagtcac ctctgagcct cctttcttct tctataaaat gagactaaca     1440

atctgtctct tgcttacctc aaaggccgtt gggaagatca aacaatattg gatgtgattg     1500

aactttataa actggagagc tacaccattt tcttctccaa ccattttacc catttcctgt     1560

ccctgagcaa acaacgcccg aaataccctc tgctacccac tagccctcac tcagtttctg     1620

cctcacaaag ctgtaacaga atgggttggg ctcaggccta attttctctg tcattccctc     1680

agcaacttgc ctatacttgt gtggccctat aattctggcc tttgtttgag agtcagccag     1740

cctgctcagg atgaaaatga ggcgcctggc ttttagcagc cataaagaac tctccttctg     1800

aatggcaagt ctctcagact cttggtctaa tggctgttgc aatgacaggc tacaaaattt     1860

ggctcacatc cctctcattc catccctctt gggtgggtgc catttggtcc agtgatttac     1920

ctgcattacg ttggtcaatt tggtctacaa catcctgcgt gtttactgca gtgtgagctg     1980

ctgcctctat cctgggtgcc tgcctcatgt gatgatttgt atacagtggc caaagacatg     2040

cttctgcttt tctgctgtct ttgttacttc ttgtgccaga gattacgttt tccctgagct     2100

tccataaagt gtttttaaac agtc                                            2124


<210>  500
<211>  333
<212>  PRT
<213>  Homo Sapiens

<400>  500

Met Leu Leu Pro Ser Lys Lys Asp Leu Lys Thr Ala Leu Asp Val Phe 
1               5                   10                  15      


Ala Val Phe Gln Trp Ser Phe Ser Ala Leu Leu Ile Thr Thr Thr Val 
            20                  25                  30          


Ile Ala Val Asn Leu Tyr Leu Val Val Phe Thr Pro Tyr Trp Pro Val 
        35                  40                  45              


Thr Val Leu Ile Leu Thr Trp Leu Ala Phe Asp Trp Lys Thr Pro Gln 
    50                  55                  60                  


Arg Gly Gly Arg Arg Phe Thr Cys Val Arg His Trp Arg Leu Trp Lys 
65                  70                  75                  80  


His Tyr Ser Asp Tyr Phe Pro Leu Lys Leu Leu Lys Thr His Asp Ile 
                85                  90                  95      


Cys Pro Ser Arg Asn Tyr Ile Leu Val Cys His Pro His Gly Leu Phe 
            100                 105                 110         


Ala His Gly Trp Phe Gly His Phe Ala Thr Glu Ala Ser Gly Phe Ser 
        115                 120                 125             


Lys Ile Phe Pro Gly Ile Thr Pro Tyr Ile Leu Thr Leu Gly Ala Phe 
    130                 135                 140                 


Phe Trp Met Pro Phe Leu Arg Glu Tyr Val Met Ser Thr Gly Ala Cys 
145                 150                 155                 160 


Ser Val Ser Arg Ser Ser Ile Asp Phe Leu Leu Thr His Lys Gly Thr 
                165                 170                 175     


Gly Asn Met Val Ile Val Val Ile Gly Gly Leu Ala Glu Cys Arg Tyr 
            180                 185                 190         


Ser Leu Pro Gly Ser Ser Thr Leu Val Leu Lys Asn Arg Ser Gly Phe 
        195                 200                 205             


Val Arg Met Ala Leu Gln His Gly Val Pro Leu Ile Pro Ala Tyr Ala 
    210                 215                 220                 


Phe Gly Glu Thr Asp Leu Tyr Asp Gln His Ile Phe Thr Pro Gly Gly 
225                 230                 235                 240 


Phe Val Asn Arg Phe Gln Lys Trp Phe Gln Ser Met Val His Ile Tyr 
                245                 250                 255     


Pro Cys Ala Phe Tyr Gly Arg Gly Phe Thr Lys Asn Ser Trp Gly Leu 
            260                 265                 270         


Leu Pro Tyr Ser Arg Pro Val Thr Thr Ile Val Gly Glu Pro Leu Pro 
        275                 280                 285             


Met Pro Lys Ile Glu Asn Pro Ser Gln Glu Ile Val Ala Lys Tyr His 
    290                 295                 300                 


Thr Leu Tyr Ile Asp Ala Leu Arg Lys Leu Phe Asp Gln His Lys Thr 
305                 310                 315                 320 


Lys Phe Gly Ile Ser Glu Thr Gln Glu Leu Glu Ile Ile 
                325                 330             


<210>  501
<211>  4131
<212>  DNA
<213>  Homo Sapiens

<400>  501
atcccgcccg catacagccc gcatcccgcc ggggaagcga gcccagtcca gcgctgcccg       60

tccagtcctc gcccaagatt taaagcccgc aagttttgtt cttgagacca gcgactttag      120

ctccgatgcg ggaaggaaag ccgacctccg atttggacat ttaaagagct gggcttgaac      180

ttcgtgagtt tcgctctaaa ctgcccttga aatgaagctg gacttggagg tggcatggaa      240

tattcacatg ggagagccgc atgaggccgc ccaccacgct tcctgaagga tgcccgtgtg      300

gaagaatttt gacgtgccag tgtcctcgtt ctacagggtg ttccattctt ccgcaatctc      360

agaaaaatgg gactaaaaga aactattttg taaaataaga agacttccat ttttaatgac      420

caacatgtat taagatggac acctactcta cgaaacacga agttctatgg tctcgaagaa      480

gcccgtgcct gtttaaaact gatcctaact aaaaacagac ttgagtggat atgagaatgt      540

tggttagtgg cagaagagtc aaaaaatggc agttaattat tcagttattt gctacttgtt      600

ttttagcgag cctcatgttt ttttgggaac caatcgataa tcacattgtg agccatatga      660

agtcatattc ttacagatac ctcataaata gctatgactt tgtgaatgat accctgtctc      720

ttaagcacac ctcagcgggg cctcgctacc aatacttgat taaccacaag gaaaagtgtc      780

aagctcaaga cgtcctcctt ttactgtttg taaaaactgc tcctgaaaac tatgatcgac      840

gttccggaat tagaaggacg tggggcaatg aaaattatgt tcggtctcag ctgaatgcca      900

acatcaaaac tctgtttgcc ttaggaactc ctaatccact ggagggagaa gaactacaaa      960

gaaaactggc ttgggaagat caaaggtaca atgatataat tcagcaagac tttgttgatt     1020

ctttctacaa tcttactctg aaattactta tgcagttcag ttgggcaaat acctattgtc     1080

cacatgccaa atttcttatg actgctgatg atgacatatt tattcacatg ccaaatctga     1140

ttgagtacct tcaaagttta gaacaaattg gtgttcaaga cttttggatt ggtcgtgttc     1200

atcgtggtgc ccctcccatt agagataaaa gcagcaaata ctacgtgtcc tatgaaatgt     1260

accagtggcc agcttaccct gactacacag ccggagctgc ctatgtaatc tccggtgatg     1320

tagctgccaa agtctatgag gcatcacaga cactaaattc aagtctttac atagacgatg     1380

tgttcatggg cctctgtgcc aataaaatag ggatagtacc gcaggaccat gtgttttttt     1440

ctggagaggg taaaactcct tatcatccct gcatctatga aaaaatgatg acatctcatg     1500

gacacttaga agatctccag gacctttgga agaatgctac agatcctaaa gtaaaaacca     1560

tttccaaagg tttttttggt caaatatact gcagattaat gaagataatt ctcctttgta     1620

aaattagcta tgtggacaca tacccttgta gggctgcgtt tatctaatag tacttgaatg     1680

ttgtatgttt tcactgtcac tgagtcaaac ctggatgaaa aaaaccttta aatgttcgtc     1740

tataccctaa gtaaaatgag gacgaaagac aaatattttg aaagcctagt ccatcagaat     1800

gtttctttga ttctagaagc tgtttaatat cacttatcta cttcattgcc taagttcatt     1860

tcaaagaatt tgtatttaga aaaggtttat attattagtg aaaacaaaac taaagggaag     1920

ttcaagttct catgtaatgc cacatatata cttgaggtgt agagatgtta ttaagaagtt     1980

ttgatgttag aataattgct tttggaaaat accaaatgaa cgtacagtac aacatttcaa     2040

ggaaatgaat atattgttag accaggtaag caagtttatt tttgttaaag agcacttggt     2100

ggaggtagta ggggcaggga aaggtcagca taggagagaa agttcatgaa tctggtaaaa     2160

cagtctcttg ttcttaagag gagatgtaga aaaatgtgta caatgttatt ataaacagac     2220

aaatcacgtc ttaccacatc catgtagcta ctggtgttag agtcattaaa ataccttttt     2280

ttgcatcttt tttcaaagtt taatgtgaac ttttagaaaa gtgattaatg ttgccctaat     2340

actttatatg tttttaatgg attttttttt aagtattaga aaatgacaca taacacgggc     2400

agctggttgc tcatagggtc cttctctagg gagaaaccat tgttaattca aataagctga     2460

ttttaatgac gttttcaact ggtttttaaa tattcaatat tggtctgtgt ttaagtttgt     2520

tatttgaatg taatttacat agaggaatat aataatggag agacttcaaa tggaaagaca     2580

gaacattaca agcctaatgt ctccataatt ttataaaatg aaatcttagt gtctaaatcc     2640

ttgtactgat tactaaaatt aacccactcc tccccaacaa ggtcttataa accacagcac     2700

tttgttccaa gttcagagtt ttaaattgag agcattaaac atcaaagtta taatatctaa     2760

aacaatttat ttttcatcaa taactgtcag aggtgatctt tattttctaa atatttcaaa     2820

cttgaaaaca gagtaaaaaa gtgatagaaa agttgccagt ttggggttaa agcattttta     2880

aagctgcatg ttccttgtaa tcaaagagat gtgtctgaga tctaatagag taagttacat     2940

ttattttaca aagcaggata aaaatgtggc tataatacac actacctccc ttcactacag     3000

aaagaactag gtggtgtcta ctgctaggga gattatatga aggccaaaat aatgacttca     3060

gcaagagtga ctgaactcac tctaaggcct ttgactgcag aggcacctgt tagggaaaat     3120

cagatgtctc atataataag gtgatgtcgg aaacacgcaa aacaaaacga aaaaagattt     3180

ctcagtatac acaactgaat gatgatactt acaattttta gcaggtagct ttttaatgtt     3240

tacagaaatt ttaatttttt tctattttga aatttgaggc ttgtttacat tgcttagata     3300

atttagaatt tttaactaat gtcaaaacta cagtgtcaaa cattctaggt tgtagttact     3360

ttcagagtag atacagggtt ttagatcatt acagtttaag ttttctgacc aattaaaaaa     3420

acatagagaa caaaagcata tttgaccaag caacaagctt ataattaatt tttattagtt     3480

gattgattaa tgatgtattg ccttttgccc atatataccc tgtgtatcta tacttggaag     3540

tgtttaaggt tgccattggt tgaaaacata agtgtctctg gccatcaaag tgatcttgtt     3600

tacagcagtg cttttgtgaa acaattattt atttgctgaa agagctcttc tgaactgtgt     3660

ccttttaatt tttgcttaga atagaatgga acaagtttaa atttcaagga aatatgaagg     3720

cacttccttt ttttctaaga aggaagttgc tagatgattc cttcatcaca cttacttaaa     3780

gtactgagaa gagtatctgt aaataaaagg gttccaacct tttaaaaaag aaggaaaaaa     3840

ctttttggtg ctccagtgta gggctatctt tttaaaaaat gtcaacaaag ggaaaataaa     3900

ctatcagctt ggatggtcac ttgaatagaa gatggttata cacagtgtta ttgttaaaat     3960

ttttttacct tttggttggt ttgcatcttt tttccatatt gttaatttta taccaaaatg     4020

ttaaatattt gtattacttg aattttgctc ttgtatggca aaataattag tgagtttaaa     4080

aaaaatctat agtttccaat aaacaactga aaaattatca tgaaaaaaaa a              4131


<210>  502
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  502

Met Arg Met Leu Val Ser Gly Arg Arg Val Lys Lys Trp Gln Leu Ile 
1               5                   10                  15      


Ile Gln Leu Phe Ala Thr Cys Phe Leu Ala Ser Leu Met Phe Phe Trp 
            20                  25                  30          


Glu Pro Ile Asp Asn His Ile Val Ser His Met Lys Ser Tyr Ser Tyr 
        35                  40                  45              


Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu 
    50                  55                  60                  


Lys His Thr Ser Ala Gly Pro Arg Tyr Gln Tyr Leu Ile Asn His Lys 
65                  70                  75                  80  


Glu Lys Cys Gln Ala Gln Asp Val Leu Leu Leu Leu Phe Val Lys Thr 
                85                  90                  95      


Ala Pro Glu Asn Tyr Asp Arg Arg Ser Gly Ile Arg Arg Thr Trp Gly 
            100                 105                 110         


Asn Glu Asn Tyr Val Arg Ser Gln Leu Asn Ala Asn Ile Lys Thr Leu 
        115                 120                 125             


Phe Ala Leu Gly Thr Pro Asn Pro Leu Glu Gly Glu Glu Leu Gln Arg 
    130                 135                 140                 


Lys Leu Ala Trp Glu Asp Gln Arg Tyr Asn Asp Ile Ile Gln Gln Asp 
145                 150                 155                 160 


Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu Leu Met Gln Phe 
                165                 170                 175     


Ser Trp Ala Asn Thr Tyr Cys Pro His Ala Lys Phe Leu Met Thr Ala 
            180                 185                 190         


Asp Asp Asp Ile Phe Ile His Met Pro Asn Leu Ile Glu Tyr Leu Gln 
        195                 200                 205             


Ser Leu Glu Gln Ile Gly Val Gln Asp Phe Trp Ile Gly Arg Val His 
    210                 215                 220                 


Arg Gly Ala Pro Pro Ile Arg Asp Lys Ser Ser Lys Tyr Tyr Val Ser 
225                 230                 235                 240 


Tyr Glu Met Tyr Gln Trp Pro Ala Tyr Pro Asp Tyr Thr Ala Gly Ala 
                245                 250                 255     


Ala Tyr Val Ile Ser Gly Asp Val Ala Ala Lys Val Tyr Glu Ala Ser 
            260                 265                 270         


Gln Thr Leu Asn Ser Ser Leu Tyr Ile Asp Asp Val Phe Met Gly Leu 
        275                 280                 285             


Cys Ala Asn Lys Ile Gly Ile Val Pro Gln Asp His Val Phe Phe Ser 
    290                 295                 300                 


Gly Glu Gly Lys Thr Pro Tyr His Pro Cys Ile Tyr Glu Lys Met Met 
305                 310                 315                 320 


Thr Ser His Gly His Leu Glu Asp Leu Gln Asp Leu Trp Lys Asn Ala 
                325                 330                 335     


Thr Asp Pro Lys Val Lys Thr Ile Ser Lys Gly Phe Phe Gly Gln Ile 
            340                 345                 350         


Tyr Cys Arg Leu Met Lys Ile Ile Leu Leu Cys Lys Ile Ser Tyr Val 
        355                 360                 365             


Asp Thr Tyr Pro Cys Arg Ala Ala Phe Ile 
    370                 375             


<210>  503
<211>  9471
<212>  DNA
<213>  Homo Sapiens

<400>  503
cagcgcgcgc tcctgcagcc ccggcggagt cccggcgggg agcgcccgcg taggcaggca       60

cccggggcag ccctccgtcc tcgccgcgcg gcctgagaac ccctgggccc tgggcgaggg      120

ggctgggctg tgcagccccc gaggctaact gggcgggatc gcagctgcag gggttgtgcg      180

agcagccacg gcggcacctg tgccctgcgg gcacccaccc tgcccctgcc gaggcaggcg      240

cccaccgccg gcggtgatgc ggctgtgaag ccctagtcga ttaacgtgac agtgtcaggt      300

ggacccacag ccatcccacc tccccctctg gggagtgctg agagtgaggc agcatggagg      360

agaggaagca tgagaccatg aacccagctc atgtcctctt tgaccggttt gtccaggcca      420

ccacctgcaa gggaaccctc aaggctttcc aggagctctg tgaccacctg gaactaaagc      480

caaaggacta ccgctccttc tatcacaagc tcaagtccaa gcttaactac tggaaagcca      540

aagccctctg ggcaaaattg gacaaacggg gcagtcacaa agactacaaa aagggaaaag      600

cgtgcactaa caccaagtgt ctcatcattg gggctggccc ctgtggtctc cgtacagcca      660

tcgacttatc cttactgggg gccaaggtgg ttgttattga gaaacgagat gccttctccc      720

gcaacaacgt cttgcatctc tggccattca ccatacatga tctacgaggt ctgggtgcca      780

agaagttcta tggcaagttc tgtgctggag ccatcgacca tatcagtatc cgtcagctcc      840

aactaatact tttgaaagta gccttgatcc taggcattga aatccacgtc aatgtggaat      900

tccaaggact tatacagcct cctgaggacc aagagaatga acggataggc tggcgggcac      960

tggtgcaccc caagactcat cctgtgtcag agtatgaatt tgaagtgatc atcggtgggg     1020

atggtcggag gaacaccttg gaagggtttc gtcggaaaga attccgtggc aaactggcca     1080

tcgccatcac ggcaaatttt atcaaccgaa atacaacagc agaagctaaa gtggaagaga     1140

tcagtggtgt ggcttttata ttcaaccaaa aatttttcca ggaactgagg gaagccacag     1200

gtattgactt ggagaacatc gtttactaca aagatgacac acactatttc gttatgacag     1260

ccaaaaagca gagtttgctg gacaaaggag tgatactaca tgactacgcc gacacagagc     1320

tcctgctttc ccgagaaaac gtggaccagg aggctctgct cagctatgcc agggaggcgg     1380

cagacttctc tacccagcag cagctgccgt ctctggattt tgccatcaat cactatgggc     1440

agcccgatgt ggccatgttt gacttcactt gtatgtatgc ctccgagaac gccgccttgg     1500

tgcgggagca gaacggacac cagttactag tggctctggt cggggacagc ctcctagagc     1560

ctttctggcc aatgggaaca ggaatagccc ggggctttct agctgctatg gactctgcct     1620

ggatggtccg aagttggtct ctaggaacga gccctttgga agtgctggca gagagggaaa     1680

gtatttacag gttgctgcct cagaccaccc ctgagaatgt gagtaagaac ttcagccagt     1740

acagtatcga ccctgtcact cggtatccca atatcaacgt caacttcctc cggccaagcc     1800

aggtgcgcca tttatatgat actggcgaaa caaaagatat tcacctggaa atggagagcc     1860

tggtgaattc ccgaaccacc cccaaattga ctcgcaatga gtctgtagct cgttcaagca     1920

aactgctggg ttggtgccag aggcagacag atggctatgc aggggtaaac gtgacagatc     1980

tcaccatgtc ctggaaaagt ggcttggccc tttgtgcaat tatccataga taccgccctg     2040

acctgataga ttttgattct ttggatgagc aaaatgtgga gaagaataac caactggcct     2100

ttgacattgc tgagaaggaa ttgggcattt ctcccatcat gacaggcaaa gaaatggcct     2160

ccgtggggga gcctgataag ctgtccatgg tgatgtacct gactcagttc tacgagatgt     2220

ttaaggactc cctcccctct agcgacacct tggacctaaa tgccgaggag aaagcagtcc     2280

tgatagccag caccagatcc cctatctcct tcctaagcaa acttggccag accatctctc     2340

ggaagcgttc tcccaaggat aaaaaggaaa aggacttgga tggtgctggg aagaggagaa     2400

agaccagtca atcagaggag gaggaagctc ctcggggcca cagaggagaa agaccgaccc     2460

tggtgagcac tctgacagac aggaggatgg acgttgccgt tgggaaccag aacaaagtga     2520

agtacatggc gacccagctg ctggccaaat ttgaagagaa tgcgcccgca cagtccatcg     2580

gcatacggag acagggctcc atgaagaagg agttcccgca gaacctggga ggcagcgaca     2640

catgctactt ctgccagaag cgggtctacg tgatggagag gctgagtgcc gagggcaagt     2700

tcttccaccg gagctgcttc aagtgcgagt actgcgccac caccctgcgc ctctcggcct     2760

acgcctacga catcgaggat ggtaaattct actgtaagcc acactactgc tatcgactct     2820

ctggctacgc acaaaggaag agaccggcag tggctcccct gtctggaaag gaggccaaag     2880

gacccctgca ggatggcgcc accacagatg caaacggacg ggccaacgcc gtggccagct     2940

ccactgagag aaccccaggt tcaggcgtga acggcctgga ggagcccagc atcgccaagc     3000

gactgagggg caccccagag cggatcgagc tggagaacta ccgcctgtcc ctgaggcagg     3060

ctgaggcact gcaggaggta ccggaggaga ctcaggccga gcacaacctg agcagcgtgc     3120

tggacacggg cgccgaggag gacgtcgcca gcagtagttc cgagtctgag atggaggagg     3180

agggagagga ggaggaggag gagcctcgcc tgcccccatc tgacctgggt ggtgttccgt     3240

ggaaggaggc cgtgcggatc catgcccttc tgaaagggaa aagtgaagag gagctagagg     3300

cctcaaagag ctttgggcct gggaatgaag aggaggagga ggaggaggaa gaatatgaag     3360

aggaggagga ggaggactat gacgaggagg aggaagagtc cagtgaagcc gggaaccaga     3420

ggctccagca ggtcatgcac gcggcggatc ctctggagat ccaggctgac gtgcactgga     3480

ctcatatccg tgagagagag gaggaagaga ggatggcgcc ggcctctgag tcctctgctt     3540

ccggagcccc attggatgag aatgacctag aggaagatgt ggactcagaa ccagccgaga     3600

tagaagggga ggcagcagag gatggggacc caggggacac tggtgctgag ctggatgatg     3660

atcagcactg gtctgacagc ccgtcggatg ctgacagaga gctgcgtttg ccgtgcccag     3720

ctgaggggga agcagagctg gagctgaggg tgtcggaaga tgaggagaag ctgcccgcct     3780

caccgaagca ccaagagaga ggtccctccc aagccaccag ccccatccgg tctccccagg     3840

aatcagctct tctgttcatt ccagtccaca gcccctcaac agaggggccc caactcccac     3900

ctgtccctgc cgccacccag gagaaatcac ctgaggagcg ccttttccct gagcctttgc     3960

tccccaaaga gaagcccaaa gctgatgccc cctcggatct gaaagctgtg cactctccca     4020

tccgatcaca gccagtgacc ctgccagaag ctaggactcc tgtctcacca gggagcccgc     4080

agccccagcc acccgtggcg gcctccacgc ccccacccag cccactcccc atctgctccc     4140

agccccagcc ttccaccgag gccactgtcc catcccctac ccagtccccc atacgcttcc     4200

agcctgcccc ggccaaaaca tccaccccac tggcccctct ccctgtccaa agccaaagtg     4260

acaccaagga cagactgggc agcccccttg ctgtggatga ggccctcaga cggagcgacc     4320

tggtggagga gttctggatg aagagtgcgg agatccgccg cagcctcggg ctcacacctg     4380

tggaccgcag caaggggccc gagcccagct tccccacgcc tgccttcagg ccagtgtccc     4440

tcaaatccta ttccgttgaa aagtcccccc aggatgaggg actccacctt ctcaagcctc     4500

tgtccatccc caaaaggctg ggcctgccaa agccggaagg cgagccgttg tccctgccaa     4560

ccccccggtc cccgtccgac agagagctac gcagcgccca ggaggagcgc agggagctgt     4620

ccagcagctc tggcctgggc ctgcacggga gctcctccaa catgaagaca ctgggcagcc     4680

agagcttcaa cacctcggac tccgccatgc tcacgccccc ctccagcccg cccccaccgc     4740

cacccccggg cgaggagccc gccaccttgc ggaggaagct cagggaggcc gagcccaatg     4800

cctcggtggt cccgccgccc ttgcccgcca cctggatgcg gcccccccgg gagcctgctc     4860

agccccccag agaggaggtg cggaagtcgt ttgtggagag cgtggaggag attccctttg     4920

ctgatgatgt ggaggacacc tatgacgaca agactgagga ctcaagcctg caggagaaat     4980

tcttcacgcc cccgtcctgc tggccgcgcc ccgagaagcc tcgccacccg cccctggcca     5040

aggagaacgg gaggctgcct gctctggagg ggacgctgca gccacagaag agggggctgc     5100

ccttggtgtc cgcggaagcc aaggagttgg ccgaggagcg catgcgagcc agggagaagt     5160

ccgtgaagag ccaggcgctg cgggacgcca tggccaggca gctgagcagg atgcagcaga     5220

tggagctggc ctcaggcgcc cccaggcccc gcaaggcgtc ctcagcaccc tcccagggca     5280

aggagcgccg gcctgactcc cccacacgcc ccactctcag gggctccgag gagcccaccc     5340

tgaagcatga agccaccagc gaggaggtcc tctccccgcc gtcggactca gggggcccag     5400

atggctcttt cacttcatcc gagggctcca gtgggaagag caagaagagg tcgtcactct     5460

tctccccccg cagaaacaag aaggagaaga agtccaaagg cgagggccgg cccccggaga     5520

agcccagctc caacctccta gaagaagccg ccgccaaacc caagtccctg tggaagtccg     5580

tcttctccgg gtacaagaag gacaagaaga agaaggccga cgacaagtcc tgccccagca     5640

ccccctccag cggggccacg gtggactctg gaaagcacag ggtgcttccc gtcgtaaggg     5700

cagagctgca gctccggcgc cagctgagct tctccgagga ctcagacctc tccagcgacg     5760

atgtccttga gaagtcctca cagaagtccc ggcgagagcc aagaacctac acggaggagg     5820

aactgaatgc caagctgacc cggcgtgtgc aaaaggcagc tcggagacag gccaagcagg     5880

aggagcttaa gcggctgcat cgagcccaga tcatccagcg gcagctgcag caggtggagg     5940

agaggcagcg gcggctggag gaaaggggcg tggctgtgga gaaggcgctc cggggcgaag     6000

caggcatggg caagaaggac gaccccaagc tgatgcagga gtggttcaag ctagtgcagg     6060

agaagaacgc catggtgcgc tacgagtcgg agctgatgat ctttgcccgg gagctggagc     6120

tggaagaccg gcagagtcga ctgcagcagg agctccggga acgcatggca gtggaagatc     6180

accttaagac tgaggaggag ctgtcagaag agaagcagat tctcaatgag atgctggagg     6240

tggtggagca gagagactca ctggtggcgc tgctggagga gcagcggctc cgggagagag     6300

aggaggacaa ggacctggag gctgccatgc tgtccaaggg cttcagcctt aactggtcct     6360

gagctcccac ccaacgctcc attttctgtt ggcatccgcc tggccaggca gtggcatcca     6420

aaccacccgg agccgcgatc tgaggaggcc tggcacctcc ttggagttta cgctcagatg     6480

cccgtgtgct gcttggaaag tggtcgagtc ccgcgtgcag tggggagccc caggtgacag     6540

tggttatctg agacggctcc acctcctggg aggaggccca cctggacctc ccactcagag     6600

gagcagcacg gcgtgtatgg catgacgcag gggaccaccc cgcgcgctcc ctgaggatgt     6660

gctggctgtg cccctttttt ccactggcac atttggtaag agagggaagc tgctccccgt     6720

cagaaccaca gtgcgccgtg cgaggggcac tgtcttcttc atgctccctg gagcaccacc     6780

aaagaaacgt aaacaatacc ccacgaaagc agggtcaggg gtcagggtgc gatcgagacc     6840

caggatgggg gcgtccagtc atgcccaccc cagcatcaca ggagacatgg aggtgcgggc     6900

aggctcctga attattatgc aaattaggag gacgcaggag gggtctgccc tccagccgaa     6960

caccacacac tggaccctaa gtggccaaat gcctgggccg cttgctggct gtggcctgag     7020

gcttgtgggt tgctgcattt tgcttgtagt tcacaaccat tttgacactg gaaaatgctg     7080

actttggggg acaggatgag gccctacatt ctaagccccc agttggcaga caggcattgt     7140

ccctgttcca catttatgtc gggacaggag atgacctttt cctccgtgtt tttcctgtgt     7200

ttgcacgttg aaatgaagct gacaacctgg caagacgctc agccgcttca aacccttttt     7260

gtcaattaac ttatttttta atacttgaaa agaagtaact tcgtttgtgt atctttacta     7320

gaggaactga tcacctgcgc ccgggtgcgg gagccacagc ggcatctggt gcgtcctacg     7380

cgacctggtc cggggctgcc cggtgctcct cacgtgcatc tatttattag cctttctctt     7440

cgtatcactg gcctggctgg catcagggag ctgcccagaa cccctgtgtg ggtcctcctc     7500

acagctttct gtcccctcct ccacccggtg cctgcctcac cctggcgcta gaccatctgg     7560

accactcatg tgatgagggt gcatttccgt tctgttttgg gccaggccaa cagcagagct     7620

gccactctca ccctcccagt gagaattccg gctctgcaga actcgccctt gtctcagttt     7680

gggggccagg gcatcacctt cctccgcaca tatgttaaag aaggtttcag gatgggccct     7740

catccacaca ggccaagagg gtgcaaggtg ggaccctgga atcatgtggc tggtgagaat     7800

tccctcctcc cagcctaaga ttcacccaga cggaaacgcg agtgctgcag tggatgctgg     7860

gatgcaggct ggtgcctctc aagcagatca gcgactcccg cccttccttc cgaaggcgac     7920

gggcacctgc cttgtgccgg atcttcatgg ggacataaag ggcgagcccc gaatcactag     7980

ctcctatagc caaactgttc ctttctcacg gttccgcacc agcctggctg tgtacagctc     8040

atcaagccac tgagctaatc ggggtggggt gcttgtccat caaagcagtc agcacatagc     8100

ccagcgagga gccatccgga ccagacccgc ctgccagggg cgctccagcc gcctgccgcc     8160

tccgtgggct ggggccagct gggagcagag gcctggcccc tccaaggcgt cccgcagtgg     8220

agcaggctga gtggctgtgc tgaccttggg ctttccatgg gaaccacact gtgcttcaac     8280

ttgaacattc atcccagctg caaaggagca aagaacctgt gtcatccttg tctgtccaga     8340

agctgccatc tctctcccat gcacatccgg gagataacgc cgctagtggc cgccacagcg     8400

ctgattctcc acctgttctc acgtgaggca aaggtctcct tttcttttct ctttacttaa     8460

aaaaggggag aggagggttt ctagattcca tcttcaaacc ccagtcgtcc cataaaattg     8520

gacgtgggaa aagaccttca ctgcctgcgt ggcctttccc agacctctcc tcgaatgcca     8580

caaaaccggt ccagccccgg cagagccgcc ttcggccctt gtagctcctg ctggccccac     8640

aacagggaaa cagtttgcaa agtggcttgg aaggagtgtg gcctagggat ctgctgtaag     8700

tggccagacg tagcaggaga gcccagtgtc accttctggt cctggtcagc cttaacactg     8760

tggcatcctc cacagcacac acggcagcct gcagtctgga aggtggaccc gagcctttgc     8820

agagaggcgc cgcagagccg caggcctgcg ccccagcctt ctgctcccga ctgtgaggac     8880

acccagttct agtagagcac tttttttaaa gctcccattt tgtaaccact agtttgcggt     8940

tgacttgagt actctggtga cttcctgcgt caagcgttct caagctgtga gaatgtgcgc     9000

agctccaggc aggttttctc tcggagagtt aagtcttccc ttgaaggcag ggaagcagga     9060

tggatacaca tatatcacac gcataaaaca ccaggtgcgg gagcagccca gactcaaggc     9120

tgactaaact ggaggctgaa taccgtggag gtccacatgc agcttccctg gagggcaggc     9180

cggaggcgct cccgcccctg ggcttgagga tgctgcaccc cgtgggcttc caggcctgcc     9240

cagatgatgc cttcaggcct ctgtccctgg cggccatcct caggccgatt ttgaccagca     9300

atgatagact cttcttaacc ctttcaaaat aaatttttca gtgggacaga aaggagagtt     9360

aaaaaacatt tttttaaagg tggtaacatc tgacccacaa agggaatggg tctgttttat     9420

gcaaaataaa agtttttcaa ataaaaaaaa aaaaaaaaaa aaaaaaaaaa a              9471


<210>  504
<211>  2002
<212>  PRT
<213>  Homo Sapiens

<400>  504

Met Glu Glu Arg Lys His Glu Thr Met Asn Pro Ala His Val Leu Phe 
1               5                   10                  15      


Asp Arg Phe Val Gln Ala Thr Thr Cys Lys Gly Thr Leu Lys Ala Phe 
            20                  25                  30          


Gln Glu Leu Cys Asp His Leu Glu Leu Lys Pro Lys Asp Tyr Arg Ser 
        35                  40                  45              


Phe Tyr His Lys Leu Lys Ser Lys Leu Asn Tyr Trp Lys Ala Lys Ala 
    50                  55                  60                  


Leu Trp Ala Lys Leu Asp Lys Arg Gly Ser His Lys Asp Tyr Lys Lys 
65                  70                  75                  80  


Gly Lys Ala Cys Thr Asn Thr Lys Cys Leu Ile Ile Gly Ala Gly Pro 
                85                  90                  95      


Cys Gly Leu Arg Thr Ala Ile Asp Leu Ser Leu Leu Gly Ala Lys Val 
            100                 105                 110         


Val Val Ile Glu Lys Arg Asp Ala Phe Ser Arg Asn Asn Val Leu His 
        115                 120                 125             


Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys 
    130                 135                 140                 


Phe Tyr Gly Lys Phe Cys Ala Gly Ala Ile Asp His Ile Ser Ile Arg 
145                 150                 155                 160 


Gln Leu Gln Leu Ile Leu Leu Lys Val Ala Leu Ile Leu Gly Ile Glu 
                165                 170                 175     


Ile His Val Asn Val Glu Phe Gln Gly Leu Ile Gln Pro Pro Glu Asp 
            180                 185                 190         


Gln Glu Asn Glu Arg Ile Gly Trp Arg Ala Leu Val His Pro Lys Thr 
        195                 200                 205             


His Pro Val Ser Glu Tyr Glu Phe Glu Val Ile Ile Gly Gly Asp Gly 
    210                 215                 220                 


Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys 
225                 230                 235                 240 


Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Thr Thr Ala 
                245                 250                 255     


Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln 
            260                 265                 270         


Lys Phe Phe Gln Glu Leu Arg Glu Ala Thr Gly Ile Asp Leu Glu Asn 
        275                 280                 285             


Ile Val Tyr Tyr Lys Asp Asp Thr His Tyr Phe Val Met Thr Ala Lys 
    290                 295                 300                 


Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Leu His Asp Tyr Ala Asp 
305                 310                 315                 320 


Thr Glu Leu Leu Leu Ser Arg Glu Asn Val Asp Gln Glu Ala Leu Leu 
                325                 330                 335     


Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ser Thr Gln Gln Gln Leu Pro 
            340                 345                 350         


Ser Leu Asp Phe Ala Ile Asn His Tyr Gly Gln Pro Asp Val Ala Met 
        355                 360                 365             


Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg 
    370                 375                 380                 


Glu Gln Asn Gly His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu 
385                 390                 395                 400 


Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Ile Ala Arg Gly Phe Leu 
                405                 410                 415     


Ala Ala Met Asp Ser Ala Trp Met Val Arg Ser Trp Ser Leu Gly Thr 
            420                 425                 430         


Ser Pro Leu Glu Val Leu Ala Glu Arg Glu Ser Ile Tyr Arg Leu Leu 
        435                 440                 445             


Pro Gln Thr Thr Pro Glu Asn Val Ser Lys Asn Phe Ser Gln Tyr Ser 
    450                 455                 460                 


Ile Asp Pro Val Thr Arg Tyr Pro Asn Ile Asn Val Asn Phe Leu Arg 
465                 470                 475                 480 


Pro Ser Gln Val Arg His Leu Tyr Asp Thr Gly Glu Thr Lys Asp Ile 
                485                 490                 495     


His Leu Glu Met Glu Ser Leu Val Asn Ser Arg Thr Thr Pro Lys Leu 
            500                 505                 510         


Thr Arg Asn Glu Ser Val Ala Arg Ser Ser Lys Leu Leu Gly Trp Cys 
        515                 520                 525             


Gln Arg Gln Thr Asp Gly Tyr Ala Gly Val Asn Val Thr Asp Leu Thr 
    530                 535                 540                 


Met Ser Trp Lys Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Tyr 
545                 550                 555                 560 


Arg Pro Asp Leu Ile Asp Phe Asp Ser Leu Asp Glu Gln Asn Val Glu 
                565                 570                 575     


Lys Asn Asn Gln Leu Ala Phe Asp Ile Ala Glu Lys Glu Leu Gly Ile 
            580                 585                 590         


Ser Pro Ile Met Thr Gly Lys Glu Met Ala Ser Val Gly Glu Pro Asp 
        595                 600                 605             


Lys Leu Ser Met Val Met Tyr Leu Thr Gln Phe Tyr Glu Met Phe Lys 
    610                 615                 620                 


Asp Ser Leu Pro Ser Ser Asp Thr Leu Asp Leu Asn Ala Glu Glu Lys 
625                 630                 635                 640 


Ala Val Leu Ile Ala Ser Thr Arg Ser Pro Ile Ser Phe Leu Ser Lys 
                645                 650                 655     


Leu Gly Gln Thr Ile Ser Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu 
            660                 665                 670         


Lys Asp Leu Asp Gly Ala Gly Lys Arg Arg Lys Thr Ser Gln Ser Glu 
        675                 680                 685             


Glu Glu Glu Ala Pro Arg Gly His Arg Gly Glu Arg Pro Thr Leu Val 
    690                 695                 700                 


Ser Thr Leu Thr Asp Arg Arg Met Asp Val Ala Val Gly Asn Gln Asn 
705                 710                 715                 720 


Lys Val Lys Tyr Met Ala Thr Gln Leu Leu Ala Lys Phe Glu Glu Asn 
                725                 730                 735     


Ala Pro Ala Gln Ser Ile Gly Ile Arg Arg Gln Gly Ser Met Lys Lys 
            740                 745                 750         


Glu Phe Pro Gln Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Gln 
        755                 760                 765             


Lys Arg Val Tyr Val Met Glu Arg Leu Ser Ala Glu Gly Lys Phe Phe 
    770                 775                 780                 


His Arg Ser Cys Phe Lys Cys Glu Tyr Cys Ala Thr Thr Leu Arg Leu 
785                 790                 795                 800 


Ser Ala Tyr Ala Tyr Asp Ile Glu Asp Gly Lys Phe Tyr Cys Lys Pro 
                805                 810                 815     


His Tyr Cys Tyr Arg Leu Ser Gly Tyr Ala Gln Arg Lys Arg Pro Ala 
            820                 825                 830         


Val Ala Pro Leu Ser Gly Lys Glu Ala Lys Gly Pro Leu Gln Asp Gly 
        835                 840                 845             


Ala Thr Thr Asp Ala Asn Gly Arg Ala Asn Ala Val Ala Ser Ser Thr 
    850                 855                 860                 


Glu Arg Thr Pro Gly Ser Gly Val Asn Gly Leu Glu Glu Pro Ser Ile 
865                 870                 875                 880 


Ala Lys Arg Leu Arg Gly Thr Pro Glu Arg Ile Glu Leu Glu Asn Tyr 
                885                 890                 895     


Arg Leu Ser Leu Arg Gln Ala Glu Ala Leu Gln Glu Val Pro Glu Glu 
            900                 905                 910         


Thr Gln Ala Glu His Asn Leu Ser Ser Val Leu Asp Thr Gly Ala Glu 
        915                 920                 925             


Glu Asp Val Ala Ser Ser Ser Ser Glu Ser Glu Met Glu Glu Glu Gly 
    930                 935                 940                 


Glu Glu Glu Glu Glu Glu Pro Arg Leu Pro Pro Ser Asp Leu Gly Gly 
945                 950                 955                 960 


Val Pro Trp Lys Glu Ala Val Arg Ile His Ala Leu Leu Lys Gly Lys 
                965                 970                 975     


Ser Glu Glu Glu Leu Glu Ala Ser Lys Ser Phe Gly Pro Gly Asn Glu 
            980                 985                 990         


Glu Glu Glu Glu Glu Glu Glu Glu  Tyr Glu Glu Glu Glu  Glu Glu Asp 
        995                 1000                 1005             


Tyr Asp  Glu Glu Glu Glu Glu  Ser Ser Glu Ala Gly  Asn Gln Arg 
    1010                 1015                 1020             


Leu Gln  Gln Val Met His Ala  Ala Asp Pro Leu Glu  Ile Gln Ala 
    1025                 1030                 1035             


Asp Val  His Trp Thr His Ile  Arg Glu Arg Glu Glu  Glu Glu Arg 
    1040                 1045                 1050             


Met Ala  Pro Ala Ser Glu Ser  Ser Ala Ser Gly Ala  Pro Leu Asp 
    1055                 1060                 1065             


Glu Asn  Asp Leu Glu Glu Asp  Val Asp Ser Glu Pro  Ala Glu Ile 
    1070                 1075                 1080             


Glu Gly  Glu Ala Ala Glu Asp  Gly Asp Pro Gly Asp  Thr Gly Ala 
    1085                 1090                 1095             


Glu Leu  Asp Asp Asp Gln His  Trp Ser Asp Ser Pro  Ser Asp Ala 
    1100                 1105                 1110             


Asp Arg  Glu Leu Arg Leu Pro  Cys Pro Ala Glu Gly  Glu Ala Glu 
    1115                 1120                 1125             


Leu Glu  Leu Arg Val Ser Glu  Asp Glu Glu Lys Leu  Pro Ala Ser 
    1130                 1135                 1140             


Pro Lys  His Gln Glu Arg Gly  Pro Ser Gln Ala Thr  Ser Pro Ile 
    1145                 1150                 1155             


Arg Ser  Pro Gln Glu Ser Ala  Leu Leu Phe Ile Pro  Val His Ser 
    1160                 1165                 1170             


Pro Ser  Thr Glu Gly Pro Gln  Leu Pro Pro Val Pro  Ala Ala Thr 
    1175                 1180                 1185             


Gln Glu  Lys Ser Pro Glu Glu  Arg Leu Phe Pro Glu  Pro Leu Leu 
    1190                 1195                 1200             


Pro Lys  Glu Lys Pro Lys Ala  Asp Ala Pro Ser Asp  Leu Lys Ala 
    1205                 1210                 1215             


Val His  Ser Pro Ile Arg Ser  Gln Pro Val Thr Leu  Pro Glu Ala 
    1220                 1225                 1230             


Arg Thr  Pro Val Ser Pro Gly  Ser Pro Gln Pro Gln  Pro Pro Val 
    1235                 1240                 1245             


Ala Ala  Ser Thr Pro Pro Pro  Ser Pro Leu Pro Ile  Cys Ser Gln 
    1250                 1255                 1260             


Pro Gln  Pro Ser Thr Glu Ala  Thr Val Pro Ser Pro  Thr Gln Ser 
    1265                 1270                 1275             


Pro Ile  Arg Phe Gln Pro Ala  Pro Ala Lys Thr Ser  Thr Pro Leu 
    1280                 1285                 1290             


Ala Pro  Leu Pro Val Gln Ser  Gln Ser Asp Thr Lys  Asp Arg Leu 
    1295                 1300                 1305             


Gly Ser  Pro Leu Ala Val Asp  Glu Ala Leu Arg Arg  Ser Asp Leu 
    1310                 1315                 1320             


Val Glu  Glu Phe Trp Met Lys  Ser Ala Glu Ile Arg  Arg Ser Leu 
    1325                 1330                 1335             


Gly Leu  Thr Pro Val Asp Arg  Ser Lys Gly Pro Glu  Pro Ser Phe 
    1340                 1345                 1350             


Pro Thr  Pro Ala Phe Arg Pro  Val Ser Leu Lys Ser  Tyr Ser Val 
    1355                 1360                 1365             


Glu Lys  Ser Pro Gln Asp Glu  Gly Leu His Leu Leu  Lys Pro Leu 
    1370                 1375                 1380             


Ser Ile  Pro Lys Arg Leu Gly  Leu Pro Lys Pro Glu  Gly Glu Pro 
    1385                 1390                 1395             


Leu Ser  Leu Pro Thr Pro Arg  Ser Pro Ser Asp Arg  Glu Leu Arg 
    1400                 1405                 1410             


Ser Ala  Gln Glu Glu Arg Arg  Glu Leu Ser Ser Ser  Ser Gly Leu 
    1415                 1420                 1425             


Gly Leu  His Gly Ser Ser Ser  Asn Met Lys Thr Leu  Gly Ser Gln 
    1430                 1435                 1440             


Ser Phe  Asn Thr Ser Asp Ser  Ala Met Leu Thr Pro  Pro Ser Ser 
    1445                 1450                 1455             


Pro Pro  Pro Pro Pro Pro Pro  Gly Glu Glu Pro Ala  Thr Leu Arg 
    1460                 1465                 1470             


Arg Lys  Leu Arg Glu Ala Glu  Pro Asn Ala Ser Val  Val Pro Pro 
    1475                 1480                 1485             


Pro Leu  Pro Ala Thr Trp Met  Arg Pro Pro Arg Glu  Pro Ala Gln 
    1490                 1495                 1500             


Pro Pro  Arg Glu Glu Val Arg  Lys Ser Phe Val Glu  Ser Val Glu 
    1505                 1510                 1515             


Glu Ile  Pro Phe Ala Asp Asp  Val Glu Asp Thr Tyr  Asp Asp Lys 
    1520                 1525                 1530             


Thr Glu  Asp Ser Ser Leu Gln  Glu Lys Phe Phe Thr  Pro Pro Ser 
    1535                 1540                 1545             


Cys Trp  Pro Arg Pro Glu Lys  Pro Arg His Pro Pro  Leu Ala Lys 
    1550                 1555                 1560             


Glu Asn  Gly Arg Leu Pro Ala  Leu Glu Gly Thr Leu  Gln Pro Gln 
    1565                 1570                 1575             


Lys Arg  Gly Leu Pro Leu Val  Ser Ala Glu Ala Lys  Glu Leu Ala 
    1580                 1585                 1590             


Glu Glu  Arg Met Arg Ala Arg  Glu Lys Ser Val Lys  Ser Gln Ala 
    1595                 1600                 1605             


Leu Arg  Asp Ala Met Ala Arg  Gln Leu Ser Arg Met  Gln Gln Met 
    1610                 1615                 1620             


Glu Leu  Ala Ser Gly Ala Pro  Arg Pro Arg Lys Ala  Ser Ser Ala 
    1625                 1630                 1635             


Pro Ser  Gln Gly Lys Glu Arg  Arg Pro Asp Ser Pro  Thr Arg Pro 
    1640                 1645                 1650             


Thr Leu  Arg Gly Ser Glu Glu  Pro Thr Leu Lys His  Glu Ala Thr 
    1655                 1660                 1665             


Ser Glu  Glu Val Leu Ser Pro  Pro Ser Asp Ser Gly  Gly Pro Asp 
    1670                 1675                 1680             


Gly Ser  Phe Thr Ser Ser Glu  Gly Ser Ser Gly Lys  Ser Lys Lys 
    1685                 1690                 1695             


Arg Ser  Ser Leu Phe Ser Pro  Arg Arg Asn Lys Lys  Glu Lys Lys 
    1700                 1705                 1710             


Ser Lys  Gly Glu Gly Arg Pro  Pro Glu Lys Pro Ser  Ser Asn Leu 
    1715                 1720                 1725             


Leu Glu  Glu Ala Ala Ala Lys  Pro Lys Ser Leu Trp  Lys Ser Val 
    1730                 1735                 1740             


Phe Ser  Gly Tyr Lys Lys Asp  Lys Lys Lys Lys Ala  Asp Asp Lys 
    1745                 1750                 1755             


Ser Cys  Pro Ser Thr Pro Ser  Ser Gly Ala Thr Val  Asp Ser Gly 
    1760                 1765                 1770             


Lys His  Arg Val Leu Pro Val  Val Arg Ala Glu Leu  Gln Leu Arg 
    1775                 1780                 1785             


Arg Gln  Leu Ser Phe Ser Glu  Asp Ser Asp Leu Ser  Ser Asp Asp 
    1790                 1795                 1800             


Val Leu  Glu Lys Ser Ser Gln  Lys Ser Arg Arg Glu  Pro Arg Thr 
    1805                 1810                 1815             


Tyr Thr  Glu Glu Glu Leu Asn  Ala Lys Leu Thr Arg  Arg Val Gln 
    1820                 1825                 1830             


Lys Ala  Ala Arg Arg Gln Ala  Lys Gln Glu Glu Leu  Lys Arg Leu 
    1835                 1840                 1845             


His Arg  Ala Gln Ile Ile Gln  Arg Gln Leu Gln Gln  Val Glu Glu 
    1850                 1855                 1860             


Arg Gln  Arg Arg Leu Glu Glu  Arg Gly Val Ala Val  Glu Lys Ala 
    1865                 1870                 1875             


Leu Arg  Gly Glu Ala Gly Met  Gly Lys Lys Asp Asp  Pro Lys Leu 
    1880                 1885                 1890             


Met Gln  Glu Trp Phe Lys Leu  Val Gln Glu Lys Asn  Ala Met Val 
    1895                 1900                 1905             


Arg Tyr  Glu Ser Glu Leu Met  Ile Phe Ala Arg Glu  Leu Glu Leu 
    1910                 1915                 1920             


Glu Asp  Arg Gln Ser Arg Leu  Gln Gln Glu Leu Arg  Glu Arg Met 
    1925                 1930                 1935             


Ala Val  Glu Asp His Leu Lys  Thr Glu Glu Glu Leu  Ser Glu Glu 
    1940                 1945                 1950             


Lys Gln  Ile Leu Asn Glu Met  Leu Glu Val Val Glu  Gln Arg Asp 
    1955                 1960                 1965             


Ser Leu  Val Ala Leu Leu Glu  Glu Gln Arg Leu Arg  Glu Arg Glu 
    1970                 1975                 1980             


Glu Asp  Lys Asp Leu Glu Ala  Ala Met Leu Ser Lys  Gly Phe Ser 
    1985                 1990                 1995             


Leu Asn  Trp Ser 
    2000         


<210>  505
<211>  1403
<212>  DNA
<213>  Homo Sapiens

<400>  505
agttacctct cccctttcac gtagttttca tttgtggtga gattctctcc caggccacaa       60

gacatttcct gctcggaacc ttgtttacta atttccactg cttttaaggc cctgcactga      120

aaatgcaagc tcaggcgccg gtggtcgttg tgacccaacc tggagtcggt cccggtccgg      180

ccccccagaa ctccaactgg cagacaggca tgtgtgactg tttcagcgac tgcggagtct      240

gtctctgtgg cacattttgt ttcccgtgcc ttgggtgtca agttgcagct gatatgaatg      300

aatgctgtct gtgtggaaca agcgtcgcaa tgaggactct ctacaggacc cgatatggca      360

tccctggatc tatttgtgat gactatatgg caactctttg ctgtcctcat tgtactcttt      420

gccaaatcaa gagagatatc aacagaagga gagccatgcg tactttctaa aaactgatgg      480

tgaaaagctc ttaccgaagc aacaaaattc agcagacacc tcttcagctt gagttcttca      540

ccatcttttg caactgaaat atgatggata tgcttaagta caactgatgg catgaaaaaa      600

atcaaatttt tgatttatta taaatgaatg ttgtccctga acttagctaa atggtgcaac      660

ttagtttctc cttgctttca tattatcgaa ttcgaatttc ctggcttata aactttttaa      720

attacatttg aaatataaac caaatgaaat attttactga taagattctt catgcttctt      780

tgctctcctt aaaatgtctt tttcactagt tagttccaag ggtcagtctc ataattttgt      840

tcttatactt tgatttcctt tttctttttt ttttttttta atagagttgg gggatctttc      900

tttctttttt tttttttttt tttgagatag agtctcgctc tgttgcccag gctggagtgc      960

agtggcgtga tctcagctca ctgcaacctc cacctcctgg atacaagcga ttctgctgcc     1020

tcagtctccc gagtagctgg gattacaggt tcccgccacc atgcccagct aatttttgta     1080

tttttagtag agacggggtt tcaccatctt ggtcaggctg gtctcgaact cctgacctcg     1140

tgatccacct gcctcggcat cacaaaatgc tgggattaca ggcatgagcc accgcgtcca     1200

gcctagagtt gggggtcttt ctatgttgcc caggctggtc ttgaactccg ggcctctagc     1260

aagcctctca tctcagcctc ccaaggtgct ggaattacag gtgtgagcca ctgcaccata     1320

ctttggtttc ttagcaggag attttggttc acagtaaccc agctctcttt catctaagaa     1380

ctttagatga gaaaaaaaaa aaa                                             1403


<210>  506
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  506

Met Gln Ala Gln Ala Pro Val Val Val Val Thr Gln Pro Gly Val Gly 
1               5                   10                  15      


Pro Gly Pro Ala Pro Gln Asn Ser Asn Trp Gln Thr Gly Met Cys Asp 
            20                  25                  30          


Cys Phe Ser Asp Cys Gly Val Cys Leu Cys Gly Thr Phe Cys Phe Pro 
        35                  40                  45              


Cys Leu Gly Cys Gln Val Ala Ala Asp Met Asn Glu Cys Cys Leu Cys 
    50                  55                  60                  


Gly Thr Ser Val Ala Met Arg Thr Leu Tyr Arg Thr Arg Tyr Gly Ile 
65                  70                  75                  80  


Pro Gly Ser Ile Cys Asp Asp Tyr Met Ala Thr Leu Cys Cys Pro His 
                85                  90                  95      


Cys Thr Leu Cys Gln Ile Lys Arg Asp Ile Asn Arg Arg Arg Ala Met 
            100                 105                 110         


Arg Thr Phe 
        115 


<210>  507
<211>  3865
<212>  DNA
<213>  Homo Sapiens

<400>  507
acagaacacg gggtgcctgg aaggggaaca gatgtgttgt ggggcacagg gcaggctggg       60

aggggaacaa aggtccactc catgggtaac cagacccttc cgccagggct ggccacttct      120

gcctttggaa aatgtttcac aacgccccat gttgtgtgtg tgtgtgaatc ggccgatgtg      180

aaccgaatgt tgatgtaaga ggcagggcac tcggctgcgg atgggtaaca gggcgtgggc      240

tggcacactt acttgcacca gtgcccagag agggggtgca ggctgaggag ctgcccagag      300

caccgctcac actcccagag tacctgaagt cggcatttca atgacaggtg acaagggtcc      360

ccaaaggcta agcgggtcca gctatggttc catctccagc ccgaccagcc cgaccagccc      420

agggccacag caagcacctc ccagagagac ctacctgagt gagaagatcc ccatcccaga      480

cacaaaaccg ggcaccttca gcctgcggaa gctatgggcc ttcacggggc ctggcttcct      540

catgagcatt gctttcctgg acccaggaaa catcgagtca gatcttcagg ctggcgccgt      600

ggcgggattc aaacttctct gggtgctgct ctgggccacc gtgttgggct tgctctgcca      660

gcgactggct gcacgtctgg gcgtggtgac aggcaaggac ttgggcgagg tctgccatct      720

ctactaccct aaggtgcccc gcaccgtcct ctggctgacc atcgagctag ccattgtggg      780

ctccgacatg caggaagtca tcggcacggc cattgcattc aatctgctct cagctggacg      840

aatcccactc tggggtggcg tcctcatcac catcgtggac accttcttct tcctcttcct      900

cgataactac gggctgcgga agctggaagc tttttttgga ctccttataa ccattatggc      960

cttgaccttt ggctatgagt atgtggtggc gcgtcctgag cagggagcgc ttcttcgggg     1020

cctgttcctg ccctcgtgcc cgggctgcgg ccaccccgag ctgctgcagg cggtgggcat     1080

tgttggcgcc atcatcatgc cccacaacat ctacctgcac tcggccctgg tcaagtctcg     1140

agagatagac cgggcccgcc gagcagacat cagagaagcc aacatgtact tcctgattga     1200

ggccaccatc gccctgtccg tctcctttat catcaacctc tttgtcatgg ctgtctttgg     1260

gcaggccttc taccagaaaa ccaaccaggc tgcgttcaac atctgtgcca acagcagcct     1320

ccacgactac gccaagatct tccccatgaa caacgccacc gtggccgtgg acatttacca     1380

ggggggcgtg atcctgggct gcctgttcgg ccccgcggcc ctctacatct gggccatagg     1440

tctcctggcg gctgggcaga gctccaccat gacgggcacc tacgcgggac agttcgtgat     1500

ggagggcttc ctgaggctgc ggtggtcacg cttcgcccgt gtcctcctca cccgctcctg     1560

cgccatcctg cccaccgtgc tcgtggctgt cttccgggac ctgagggact tgtcgggcct     1620

caatgatctg ctcaacgtgc tgcagagcct gctgctcccg ttcgccgtgc tgcccatcct     1680

cacgttcacc agcatgccca ccctcatgca ggagtttgcc aatggcctgc tgaacaaggt     1740

cgtcacctct tccatcatgg tgctagtctg cgccatcaac ctctacttcg tggtcagcta     1800

tctgcccagc ctgccccacc ctgcctactt cggccttgca gccttgctgg ccgcagccta     1860

cctgggcctc agcacctacc tggtctggac ctgttgcctt gcccacggag ccacctttct     1920

ggcccacagc tcccaccacc acttcctgta tgggctcctt gaagaggacc agaaagggga     1980

gacctctggc taggcccaca ccagggcctg gctgggagtg gcatgtatga cgtgactggc     2040

ctgctggatg tggagggggc gcgtgcaggc agcaggatag agtgggacag ttcctgagac     2100

cagccaacct gggggcttta gggacctgct gtttcctagc gcagccatgt gattaccctc     2160

tgggtctcag tgtcctcatc tgtaaaatgg agacaccacc acccttgcca tggaggttaa     2220

gcactttaac acagtgtctg gcacttggga caaaaacaaa caaacgaaaa acatttcaaa     2280

aggtatttat tgagcacctg caggcgtgac ctgacagccc aagggtgggt ggggtgaggg     2340

cttgaggact tgggcgggac acaggctcca aactggagct tgaaatagtg tctgatgaat     2400

gttaaattat ctatctatct atttatttat ttatttgaga cagggaaagg gtctccctct     2460

gttgccaagg ctggagtgca gtggcgcaat cttaactcat tgcaacctcc accttctggg     2520

ttcaagcgat tctctttatt cagccccggg agtggcgcgc gccaccacgc ccagctaatt     2580

tgtgtatttt cagcagagac ggggtttgcc atgctggcca ggctggtctc gaactgctgg     2640

attcaagtga tccgcccatc tccgtctccc aaagtgctgg gaattacagg cgtgagccac     2700

caaacccggc ctgattaaag ttaaataaat actagttccc ttctcgtcca aaggagcagg     2760

gaatgggaac cgggaaggca cgaagtctct aaagcatcca gaagacccct acaccagggt     2820

ctggtccgct cctattcgcc gcagcctttc tgttccgcct gcaacccatt ttccagacag     2880

taaaacggcg gcgcacttct ttctccgtca ggcaccaggt cataaggaac ccaagagtct     2940

gtgcctctga ggcccaaatt atttgctgtt tcctcagggg agccggcggc cgcgactccc     3000

acgccgcgcc gttaccgctc cctctctgct gactgctccc cctaggggca gagacggtcc     3060

cgacgcccgc catcccgccc cggcctcacc cctccccgcc aggcggaacg acgcggggag     3120

gcgggcgctc ggggctcgcg ccaggggccc cagaatcctt cggggagagt gggtgggagg     3180

aagctgtgtg ggcggggagc cccctctgcc ttagggagcg gctgggcacc cattcgcccc     3240

attcaggggc tgcactttat agacgttccc taggctgttt ctaggctccc ccaagtccct     3300

cctccagcct cgtcgggtcc ctcagacccc agcccaggac ctgcggaggg ccgcagcgag     3360

gagaggccaa caggcctttc cctagagttg aacctgggcc gggtgttgca cctggaagaa     3420

cccccgattt cctggggacc cagcagggca ggcggcctgg ctccgcgctc aggtccggac     3480

gcttgtttat gagaagaatt tcctctttct taaaagggca acgatgcgag tgggtccctc     3540

aaggagagaa gagatgggac cggtctggtg cgacctgggc aagcgctgca gagggtacct     3600

gggcaagagg gccgcccgcc tcctctgggt ttggcactgg agaagatggg tccatgccag     3660

ctgaaggagg agatggatgg gggacgttta gcgaagaaag gcatctccca gatcctttag     3720

cctcctggaa gtgcccccgt tgtaccccct acacacccct cttggcattg agtgccagtc     3780

ctctgccagg ctctgtgtta caagttgggg agggcggcaa agtcccgaat taaagatgtc     3840

agttctcaag gaaaaaaaaa aaaaa                                           3865


<210>  508
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  508

Met Thr Gly Asp Lys Gly Pro Gln Arg Leu Ser Gly Ser Ser Tyr Gly 
1               5                   10                  15      


Ser Ile Ser Ser Pro Thr Ser Pro Thr Ser Pro Gly Pro Gln Gln Ala 
            20                  25                  30          


Pro Pro Arg Glu Thr Tyr Leu Ser Glu Lys Ile Pro Ile Pro Asp Thr 
        35                  40                  45              


Lys Pro Gly Thr Phe Ser Leu Arg Lys Leu Trp Ala Phe Thr Gly Pro 
    50                  55                  60                  


Gly Phe Leu Met Ser Ile Ala Phe Leu Asp Pro Gly Asn Ile Glu Ser 
65                  70                  75                  80  


Asp Leu Gln Ala Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu 
                85                  90                  95      


Leu Trp Ala Thr Val Leu Gly Leu Leu Cys Gln Arg Leu Ala Ala Arg 
            100                 105                 110         


Leu Gly Val Val Thr Gly Lys Asp Leu Gly Glu Val Cys His Leu Tyr 
        115                 120                 125             


Tyr Pro Lys Val Pro Arg Thr Val Leu Trp Leu Thr Ile Glu Leu Ala 
    130                 135                 140                 


Ile Val Gly Ser Asp Met Gln Glu Val Ile Gly Thr Ala Ile Ala Phe 
145                 150                 155                 160 


Asn Leu Leu Ser Ala Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile 
                165                 170                 175     


Thr Ile Val Asp Thr Phe Phe Phe Leu Phe Leu Asp Asn Tyr Gly Leu 
            180                 185                 190         


Arg Lys Leu Glu Ala Phe Phe Gly Leu Leu Ile Thr Ile Met Ala Leu 
        195                 200                 205             


Thr Phe Gly Tyr Glu Tyr Val Val Ala Arg Pro Glu Gln Gly Ala Leu 
    210                 215                 220                 


Leu Arg Gly Leu Phe Leu Pro Ser Cys Pro Gly Cys Gly His Pro Glu 
225                 230                 235                 240 


Leu Leu Gln Ala Val Gly Ile Val Gly Ala Ile Ile Met Pro His Asn 
                245                 250                 255     


Ile Tyr Leu His Ser Ala Leu Val Lys Ser Arg Glu Ile Asp Arg Ala 
            260                 265                 270         


Arg Arg Ala Asp Ile Arg Glu Ala Asn Met Tyr Phe Leu Ile Glu Ala 
        275                 280                 285             


Thr Ile Ala Leu Ser Val Ser Phe Ile Ile Asn Leu Phe Val Met Ala 
    290                 295                 300                 


Val Phe Gly Gln Ala Phe Tyr Gln Lys Thr Asn Gln Ala Ala Phe Asn 
305                 310                 315                 320 


Ile Cys Ala Asn Ser Ser Leu His Asp Tyr Ala Lys Ile Phe Pro Met 
                325                 330                 335     


Asn Asn Ala Thr Val Ala Val Asp Ile Tyr Gln Gly Gly Val Ile Leu 
            340                 345                 350         


Gly Cys Leu Phe Gly Pro Ala Ala Leu Tyr Ile Trp Ala Ile Gly Leu 
        355                 360                 365             


Leu Ala Ala Gly Gln Ser Ser Thr Met Thr Gly Thr Tyr Ala Gly Gln 
    370                 375                 380                 


Phe Val Met Glu Gly Phe Leu Arg Leu Arg Trp Ser Arg Phe Ala Arg 
385                 390                 395                 400 


Val Leu Leu Thr Arg Ser Cys Ala Ile Leu Pro Thr Val Leu Val Ala 
                405                 410                 415     


Val Phe Arg Asp Leu Arg Asp Leu Ser Gly Leu Asn Asp Leu Leu Asn 
            420                 425                 430         


Val Leu Gln Ser Leu Leu Leu Pro Phe Ala Val Leu Pro Ile Leu Thr 
        435                 440                 445             


Phe Thr Ser Met Pro Thr Leu Met Gln Glu Phe Ala Asn Gly Leu Leu 
    450                 455                 460                 


Asn Lys Val Val Thr Ser Ser Ile Met Val Leu Val Cys Ala Ile Asn 
465                 470                 475                 480 


Leu Tyr Phe Val Val Ser Tyr Leu Pro Ser Leu Pro His Pro Ala Tyr 
                485                 490                 495     


Phe Gly Leu Ala Ala Leu Leu Ala Ala Ala Tyr Leu Gly Leu Ser Thr 
            500                 505                 510         


Tyr Leu Val Trp Thr Cys Cys Leu Ala His Gly Ala Thr Phe Leu Ala 
        515                 520                 525             


His Ser Ser His His His Phe Leu Tyr Gly Leu Leu Glu Glu Asp Gln 
    530                 535                 540                 


Lys Gly Glu Thr Ser Gly 
545                 550 


<210>  509
<211>  4107
<212>  DNA
<213>  Homo Sapiens

<400>  509
ggtccctggt acgcggcgga tgggcgccgg caggagcggg cagggcgagg cgaaggccgg       60

ggagggatcg agaacggtgt gggagagcta ggctcggggg gcgaggcccc ggcccggcgg      120

ggcgatggag gcgctgctct ccacccccat caaccccaac aacttccccg ccaagctgtg      180

gcgcctggtg aacagcccgc gctaccgctc catccgctgg gacggccgcg gcgaggggct      240

gcttatcgat cagccgctct tcgaggccga gctgctcagc ccgcccgggc cggggggcgg      300

tggcgggact gcgggggccg gggccgagcc cgagctcttc aaaaccacca gcttcaccag      360

cttcatccgc cagctcaacc tctacggctt ccgcaaggtg gtgctgggcg ggccgggggg      420

cggcaaaccg gcaggcaatg ggccgctcca tcacttccac aacccgcact tccgccgcga      480

ccagccacag ctgctcgtgc acctcaagcg cctcaccagc gccaacaagg ccaagctggc      540

ggccggcctg gaggtgccct gccgcccgcc caaccgcttc cagcggctgc tcatcacctc      600

ggcctccgcc gccaccgcgc cactgcagca ccagcagccg ccgccgcccg cggggccccg      660

gcccgagccg cacggaccag tggctgtagg acaatttcac cggtcatttc gtcgagatag      720

tttgtctcct tactcctgtg tatcaactcc atcccacgac cacagtactt accctctgaa      780

aggtttagat cggaccccag ttcctcatag aatatggcag aactcccttg gaatgcatcc      840

tggacaagtg gagacatctc ccacattttc agataaaggg gttccgtttc ctgtactcca      900

gaggtttcca actgaggtta cctatacact gcagcccagc accacatctg tacatgttca      960

acaaggtcct caaacaatgg tcagctcctc ccaaaaatac agtaactaca caccctcagc     1020

acagtactcg caagcctact atccaacagc tgtgctacag tgctgttctc ctacccacat     1080

ggatgctcta agtagttgtg tcactcccaa tgcctcttcc tatgcacact gcaactactt     1140

ccagaatcct tcaatgcagt cctcctatcc agttgaattt ttgccttcca attggccctg     1200

cagtactact gatgaaaata caaagacaga agtaaaccta gaggctgtct ttcagatagt     1260

tgatgagttg cattcctccc ctaaattgga gatggtaaag gtggagcctg ttgagaatca     1320

gtgcccaaca tctccgtctt acagaggcca acacatttta gctaattcta acaacagcaa     1380

tccatgttct gcaagtcagg ctagccagct ggagccactt actcctgtag gctcagatat     1440

tatgtctttt gtggttggaa cagaacaagc agttgcctgc tctctaccac agtcacctga     1500

gtacatctat accatccaca cagctcagcc tgttgaaaat agcacaatac aggaatctgc     1560

agccatccag caagctcatg tcaaactgaa ggagcaccta aatcataatc catctccatc     1620

ttcagtagta tttgtgcagg aagggccacc attcagcaca caccaggtgg atgccaacat     1680

aaaatgccag accagttcac gtgagaatat cttgccgtca gaacagatgg gattcctcat     1740

ttcagaaatg gggcctgcta gcaagcctag tgaagacaca ggtttagcca ctccagccag     1800

atacagagag cacagaagca actcacaaca aggaaagtcc cctgatcttc atctgctggt     1860

ggacgtggcc tgcaagcagg agcgctttcc aaaggaggaa gaattaaaag agtgaggaat     1920

ggatgacaaa tgtgacattg tgcactagct gtagctggag gcagactagc cttgcacatg     1980

acaaactgtt gggatttttt cagttctgtt aaggaaaaaa aagtattttt tgtttcgtta     2040

attgagaatt ttgttaattg agaattggga atttgtatgt actacagtgg ttcagttcag     2100

attatctgcc ttgacaaact actgaacatc tagcagccac gttttttggc tgcccagatc     2160

ccttttaaat gaaaagttct gaccttctgt tatagtcaag gagcatctaa aaactgctcc     2220

atctatggta ctaagaataa tctgtgtgtg tgctgatttg ttgtcttgcc actcaaactg     2280

tagtcagcac aactttagtg gggaattcag tctctctgat tcaagtcaca gtgtgatcct     2340

tttagaggag attgtgtgag aaacaaaggc atgtgaggtc accagcatca caggtctaaa     2400

tgcatcagga attccaggga agaaactctg gagaagagct aattttctaa gtgattaacc     2460

aggaaattct cttacttcct aacccagcat tctgttttaa gagcaaggca tccggacttg     2520

gaccatctat cacacttaac agcccctgat tcttttatat taatggaagc attcttctat     2580

tttcatatct ttctttaatt ttaatgatac attatcataa atggtaaaaa gattttatta     2640

atatatcact tatttaaatg tctttaaaga aagtatttaa cttgtttaat ataattgtat     2700

ttataaatgc tgatagattt aaaggtttta aagttttata tttttattat tgcaggatag     2760

aaggataaag gatgcatgtg tagtattttt attttgaaag gaaaatgtac aatgtgtgaa     2820

caaaaacatt aagagattta atatactatt ttcttatttt agatttttac attcaataag     2880

tataaattct catctatata aggtattgtg tgcaaatttg ggaaaaaact gattagcagc     2940

catttagtag aagctatgcc tctgattttt aaagaatggt ttcaatctgg tttaagcttc     3000

tgagagaatt ttggataatg ggatagatgg taacattttt ttcttatccc tgttacagga     3060

ttctagattt gtgcagtagg attgtgggac tgtgttttag gagagaagga tgtcttggat     3120

gtccagtttc tgtggttaat cccttacttg cttatccagt gacagcaaga aactttctga     3180

tttaaagtct ttcaattgac caaaactttc ttattggatt ctgtttcagt tctcctatta     3240

agcactgcag aaacgaaagg aaagcctagg aatatgaaac taattaaaaa ggcacttggt     3300

gatatgacat agtactatgc tagccgttgt ggatgtaaca gttcatttct tatactgcat     3360

tgtgccttcc caatgatgtc aaaccctaga aatattacag agatctactt ttctggaaaa     3420

gggtgagctc tgtattgatc tgcagtgact ctgtttagat attaaagtag gttctgaaaa     3480

gcgacctgtg tggtccctct gattagacta gttaatgtct atgtgatggg catttattta     3540

tctttattag caaggtttaa aagagcaaat tatcaagaca cctatatctt ttggccagac     3600

tatataatat tttgtcagag tatgtgaaga ggagacccaa tttccaaatg aaggaacttt     3660

gctttttctc tgtcatgttg aagagctaat atactgtgta gattttcccc taaatatggc     3720

tttcttagct ttatagatgt tgagataata tcttttgagg aacacatgtc aagcaggaac     3780

cttggcatag atttggtttc agttgtttta aggcttaatt aatgaaatgc cttaatcagc     3840

tttccaaaca tttttatata tgaatacagc agaccaagga gctggatctc ctgctatcct     3900

tacacgcctt gtatctatca actaaagctg tcattaatga cttgggcaaa atggcaagag     3960

gtataataaa gtcttcctgt gaattagcca gtagggtctg acacaactag tcaactaaca     4020

aggttcctga ctagtacctc agtatttcag caccttaagc actgataaat ttcaatcagt     4080

caacaataaa gtgagtgttc caactag                                         4107


<210>  510
<211>  596
<212>  PRT
<213>  Homo Sapiens

<400>  510

Met Glu Ala Leu Leu Ser Thr Pro Ile Asn Pro Asn Asn Phe Pro Ala 
1               5                   10                  15      


Lys Leu Trp Arg Leu Val Asn Ser Pro Arg Tyr Arg Ser Ile Arg Trp 
            20                  25                  30          


Asp Gly Arg Gly Glu Gly Leu Leu Ile Asp Gln Pro Leu Phe Glu Ala 
        35                  40                  45              


Glu Leu Leu Ser Pro Pro Gly Pro Gly Gly Gly Gly Gly Thr Ala Gly 
    50                  55                  60                  


Ala Gly Ala Glu Pro Glu Leu Phe Lys Thr Thr Ser Phe Thr Ser Phe 
65                  70                  75                  80  


Ile Arg Gln Leu Asn Leu Tyr Gly Phe Arg Lys Val Val Leu Gly Gly 
                85                  90                  95      


Pro Gly Gly Gly Lys Pro Ala Gly Asn Gly Pro Leu His His Phe His 
            100                 105                 110         


Asn Pro His Phe Arg Arg Asp Gln Pro Gln Leu Leu Val His Leu Lys 
        115                 120                 125             


Arg Leu Thr Ser Ala Asn Lys Ala Lys Leu Ala Ala Gly Leu Glu Val 
    130                 135                 140                 


Pro Cys Arg Pro Pro Asn Arg Phe Gln Arg Leu Leu Ile Thr Ser Ala 
145                 150                 155                 160 


Ser Ala Ala Thr Ala Pro Leu Gln His Gln Gln Pro Pro Pro Pro Ala 
                165                 170                 175     


Gly Pro Arg Pro Glu Pro His Gly Pro Val Ala Val Gly Gln Phe His 
            180                 185                 190         


Arg Ser Phe Arg Arg Asp Ser Leu Ser Pro Tyr Ser Cys Val Ser Thr 
        195                 200                 205             


Pro Ser His Asp His Ser Thr Tyr Pro Leu Lys Gly Leu Asp Arg Thr 
    210                 215                 220                 


Pro Val Pro His Arg Ile Trp Gln Asn Ser Leu Gly Met His Pro Gly 
225                 230                 235                 240 


Gln Val Glu Thr Ser Pro Thr Phe Ser Asp Lys Gly Val Pro Phe Pro 
                245                 250                 255     


Val Leu Gln Arg Phe Pro Thr Glu Val Thr Tyr Thr Leu Gln Pro Ser 
            260                 265                 270         


Thr Thr Ser Val His Val Gln Gln Gly Pro Gln Thr Met Val Ser Ser 
        275                 280                 285             


Ser Gln Lys Tyr Ser Asn Tyr Thr Pro Ser Ala Gln Tyr Ser Gln Ala 
    290                 295                 300                 


Tyr Tyr Pro Thr Ala Val Leu Gln Cys Cys Ser Pro Thr His Met Asp 
305                 310                 315                 320 


Ala Leu Ser Ser Cys Val Thr Pro Asn Ala Ser Ser Tyr Ala His Cys 
                325                 330                 335     


Asn Tyr Phe Gln Asn Pro Ser Met Gln Ser Ser Tyr Pro Val Glu Phe 
            340                 345                 350         


Leu Pro Ser Asn Trp Pro Cys Ser Thr Thr Asp Glu Asn Thr Lys Thr 
        355                 360                 365             


Glu Val Asn Leu Glu Ala Val Phe Gln Ile Val Asp Glu Leu His Ser 
    370                 375                 380                 


Ser Pro Lys Leu Glu Met Val Lys Val Glu Pro Val Glu Asn Gln Cys 
385                 390                 395                 400 


Pro Thr Ser Pro Ser Tyr Arg Gly Gln His Ile Leu Ala Asn Ser Asn 
                405                 410                 415     


Asn Ser Asn Pro Cys Ser Ala Ser Gln Ala Ser Gln Leu Glu Pro Leu 
            420                 425                 430         


Thr Pro Val Gly Ser Asp Ile Met Ser Phe Val Val Gly Thr Glu Gln 
        435                 440                 445             


Ala Val Ala Cys Ser Leu Pro Gln Ser Pro Glu Tyr Ile Tyr Thr Ile 
    450                 455                 460                 


His Thr Ala Gln Pro Val Glu Asn Ser Thr Ile Gln Glu Ser Ala Ala 
465                 470                 475                 480 


Ile Gln Gln Ala His Val Lys Leu Lys Glu His Leu Asn His Asn Pro 
                485                 490                 495     


Ser Pro Ser Ser Val Val Phe Val Gln Glu Gly Pro Pro Phe Ser Thr 
            500                 505                 510         


His Gln Val Asp Ala Asn Ile Lys Cys Gln Thr Ser Ser Arg Glu Asn 
        515                 520                 525             


Ile Leu Pro Ser Glu Gln Met Gly Phe Leu Ile Ser Glu Met Gly Pro 
    530                 535                 540                 


Ala Ser Lys Pro Ser Glu Asp Thr Gly Leu Ala Thr Pro Ala Arg Tyr 
545                 550                 555                 560 


Arg Glu His Arg Ser Asn Ser Gln Gln Gly Lys Ser Pro Asp Leu His 
                565                 570                 575     


Leu Leu Val Asp Val Ala Cys Lys Gln Glu Arg Phe Pro Lys Glu Glu 
            580                 585                 590         


Glu Leu Lys Glu 
        595     


<210>  511
<211>  2974
<212>  DNA
<213>  Homo Sapiens

<400>  511
agaagccccg cagccgccgc gcggagaaca gcgacagccg agcgcccggt ccgcctgtct       60

gccggtgggt ctgcctgccc gcgcagcaga cccggggcgg ccgcgggagc ccgcgccccg      120

cccgccgcgc ctctgccggg acccacccgc agcggagggc tgagcccgcc ggcggctccc      180

cggagctcac ccacctccgc gcgccggagc gcaggcaaaa ggggaggaaa ggctcctctc      240

tttagtcacc actctcgccc tctccaagaa tttgtttaac aaagcgctga ggaaagagaa      300

cgtcttcttg aattctttag taggggcgga gtctgctgct gccctgcgct gccacctcgg      360

ctacactgcc ctccgcgacg acccctgacc agccggggtc acgtccggga gacgggatca      420

tgaagcgctc ggtagccgtc tggctcttgg tcgggctcag cctcggtgtc ccccagttcg      480

gcaaaggtga tatttgtgat cccaatccat gtgaaaatgg aggtatctgt ttgccaggat      540

tggctgatgg ttccttttcc tgtgagtgtc cagatggctt cacagacccc aactgttcta      600

gtgttgtgga ggttgcatca gatgaagaag aaccaacttc agcaggtccc tgcactccta      660

atccatgcca taatggagga acctgtgaaa taagtgaagc ataccgaggg gatacattca      720

taggctatgt ttgtaaatgt ccccgaggat ttaatgggat tcactgtcag cacaacataa      780

atgaatgcga agttgagcct tgcaaaaatg gtggaatatg tacagatctt gttgctaact      840

attcctgtga gtgcccaggc gaatttatgg gaagaaattg tcaatacaaa tgctcaggcc      900

cactgggaat tgaaggtgga attatatcaa accagcaaat cacagcttcc tctactcacc      960

gagctctttt tggactccaa aaatggtatc cctactatgc acgtcttaat aagaaggggc     1020

ttataaatgc gtggacagct gcagaaaatg acagatggcc gtggattcag ataaatttgc     1080

aaaggaaaat gagagttact ggtgtgatta cccaaggagc caagaggatt ggaagcccag     1140

agtatataaa atcctacaaa attgcctaca gtaatgatgg aaagacttgg gcaatgtaca     1200

aagtgaaagg caccaatgaa gacatggtgt ttcgtggaaa cattgataac aacactccat     1260

atgctaactc tttcacaccc cccataaaag ctcagtatgt aagactctat ccccaagttt     1320

gtcgaagaca ttgcactttg cgaatggaac ttcttggctg tgaactgtcg ggttgttctg     1380

agcctctggg tatgaaatca ggacatatac aagactatca gatcactgcc tccagcatct     1440

tcagaacgct caacatggac atgttcactt gggaaccaag gaaagctcgg ctggacaagc     1500

aaggcaaagt gaatgcctgg acctctggcc acaatgacca gtcacaatgg ttacaggtgg     1560

atcttcttgt tccaaccaaa gtgactggca tcattacaca aggagctaaa gattttggtc     1620

atgtacagtt tgttggctcc tacaaactgg cttacagcaa tgatggagaa cactggactg     1680

tataccagga tgaaaagcaa agaaaagata aggttttcca gggaaatttt gacaatgaca     1740

ctcacagaaa aaatgtcatc gaccctccca tctatgcacg acacataaga atccttcctt     1800

ggtcctggta cgggaggatc acattgcggt cagagctgct gggctgcaca gaggaggaat     1860

gaggggaggc tacatttcac aaccctcttc cctatttccc taaaagtatc tccatggaat     1920

gaactgtgca aaatctgtag gaaactgaat ggtttttttt tttttttcat gaaaaagtgc     1980

tcaaattatg gtaggcaact aacggtgttt ttaagggggt ctaagcctgc cttttcaatg     2040

atttaatttg attttatttt atccgtcaaa tctcttaagt aacaacacat taagtgtgaa     2100

ttacttttct ctcattgttt cctgaattat tcgcattggt agaaatatat tagggaaaga     2160

aagtagcctt ctttttatag caagagtaaa aaagtctcaa agtcatcaaa taagagcaag     2220

agttgataga gcttttacaa tcaatactca cctaattctg ataaaaggaa tactgcaatg     2280

ttagcaataa gtttttttct tctgtaatga ctctacgtta tcctgtttcc ctgtgcctac     2340

caaacactgt caatgtttat tacaaaattt taaagaagaa tatgtaacat gcagtactga     2400

tattataatt ctcattttac tttcattatt tctaataaga gattatgtga cttctttttc     2460

ttttagttct attctacatt cttaatattg tatattacct gaataattca atttttttct     2520

aattgaattt cctattagtt gactaaaaga agtgtcatgt ttactcatat atgtagaaca     2580

tgactgccta tcagtagatt gatctgtatt taatattcgt taattaaatc tgcagtttta     2640

tttttgaagg aagccataac tatttaattt ccaaataatt gcttcataaa gaatcccata     2700

ctctcagttt gcacaaaaga acaaaaaata tatatgtctc tttaaattta aatcttcatt     2760

tagatggtaa ttacatatcc ttatatttac tttaaaaaat cggcttattt gtttatttta     2820

taaaaaattt agcaaagaaa tattaatata gtgctgcata gtttggccaa gcatactcat     2880

catttctttg ttcagctcca catttcctgt gaaactaaca tcttattgag atttgaaact     2940

ggtggtagtt tcccaggaag gcacaggtgg agtt                                 2974


<210>  512
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  512

Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro 
65                  70                  75                  80  


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg 
                85                  90                  95      


Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn 
            100                 105                 110         


Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys 
        115                 120                 125             


Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu 
    130                 135                 140                 


Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 
                165                 170                 175     


Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 
            180                 185                 190         


Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 
        195                 200                 205             


Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 
    210                 215                 220                 


Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 
225                 230                 235                 240 


Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 
                245                 250                 255     


Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 
            260                 265                 270         


Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 
        275                 280                 285             


Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 
    290                 295                 300                 


Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 
305                 310                 315                 320 


Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 
                325                 330                 335     


Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 
            340                 345                 350         


Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 
        355                 360                 365             


Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 
    370                 375                 380                 


Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 
385                 390                 395                 400 


His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 
                405                 410                 415     


Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 
            420                 425                 430         


Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 
        435                 440                 445             


Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr 
    450                 455                 460                 


Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu 
465                 470                 475                 480 


<210>  513
<211>  3076
<212>  DNA
<213>  Homo Sapiens

<400>  513
acggcgcagg ctccgcggcc cgagcaggcg cgtcagccga gctcggcggt ggcgcgggcg       60

gctgggacgc agctgccccc gctcggcgcc cgctgcaccc ttagcagcca ctgccacctg      120

ggcccggagc ctccacgatc tcgcccggcg attgtgggca ggggcgcctc cggatcgatc      180

ttctgaaatt caagttttca agatgaagtt tttattgaca actgcctttt taattttaat      240

ttccttgtgg gtggaagaag cctattctaa ggaaaagtct tcaaagaaag ggaaggggaa      300

aaagaagcag tatctatgcc catctcagca gtcagcagag gaccttgccc gagtacctgc      360

caactccact agcaatatct tgaacaggtt attggtcagt tatgatccca ggataagacc      420

aaacttcaaa ggcattcctg ttgatgtagt agtcaacatt tttattaaca gttttggatc      480

cattcaagaa acaacaatgg actatagagt taacatcttc ctgagacaaa aatggaatga      540

ccccaggctg aagctcccca gtgattttag gggttcagat gcactgacag tggatccaac      600

aatgtacaag tgtttatgga aacctgattt attttttgca aatgaaaaaa gtgccaattt      660

tcatgatgtg acccaggaaa acatcctcct ctttattttt cgtgatggag atgtccttgt      720

cagcatgagg ttatctatta ctctttcatg ccctttggac ttgacattgt ttcccatgga      780

tacacaacgt tgcaagatgc aactggagag ctttggttac acaactgatg atttacgatt      840

tatctggcag tcaggagatc ctgtgcaatt agaaaaaatt gccttgcctc aatttgatat      900

caaaaaggaa gatattgaat atggtaactg tacaaaatac tataaaggca cgggctacta      960

cacatgcgtg gaagtcatct tcaccctgag gaggcaggtc ggcttttaca tgatgggggt     1020

ctacgcccca accctgctca ttgttgttct ctcctggctt tccttctgga tcaacccgga     1080

cgcgagtgct gccagagtgc ccctgggtat cttctcagtc ctcagcttgg cctctgagtg     1140

cacaaccctt gccgctgagc ttcccaaagt ttcctatgtg aaggctcttg atgtttggct     1200

tattgcttgc cttctctttg ggtttgcttc cctggtggag tatgcagttg tccaggtgat     1260

gctgaacaac cccaaaaggg ttgaagctga aaaagccaga attgctaagg ctgagcaagc     1320

agatggaaaa ggtggaaatg tggctaaaaa gaatactgtg aatggaacag ggactcctgt     1380

tcatattagc actttgcagg ttggtgagac cagatgcaaa aaagtttgta cttctaagtc     1440

tgatctgaga tctaatgact tcagcattgt tggaagctta ccaagagatt ttgaactatc     1500

caattatgac tgctatggaa aacccattga agttaacaac ggacttggga aatctcaggc     1560

taagaacaac aagaagcctc cccctgcgaa acctgttatt ccaacagcag caaagcgaat     1620

tgatctttat gcaagagcat tgtttccttt ctgcttcttg ttcttcaatg ttatatattg     1680

gtctatatat ttatgataaa tcttttccat ttgtacaaaa taaaattcca tttcattgtg     1740

acctactcct ttcataaatg ccaatctgtg agaacttttg aattttcata gcaacattgc     1800

attttggatg ccatttgatt gtaataaaac tgtggcacct taattttgaa tggcagcatg     1860

atcatgtaat atctgtgctc taataacgat gtatatatgt atagtgaaca tattgcttag     1920

taacaaatga aggacaagca tactacataa tataatccat acaattctct tcagttagtg     1980

taaactgcaa atactacaga taattctgat aataaaatga tatgcacgct gaatcctgct     2040

atggtcacca ttctaatgta tgtagtattt caaatttcct tccttgtaac tttcaaagaa     2100

agccatctta ttcttgtaaa attttagatg gtattatcac agatttaaaa aggttgtatt     2160

acatattgtt taaactttgt aagtagaaat atatctgtta taattataca ggctctgtgg     2220

agaaataaag ttcaaaatat attaatttgt aaaatcagct cgttttaaag tgtgcttgtg     2280

ttgtcaaaaa tatcagatag taatacacag tgagcatttt taaacaaagg gaaacctata     2340

tttatgtaac tgtatactga attctgacaa aataaaaaaa gataccttat tgacgaaata     2400

tttaggataa acaaaattct atttaatcca ccttaaaacc taaatgtatt ttcatggatt     2460

tcatttgttg gtacatatta cacaaaacat tgtgccttaa aatgagtcat acatctttta     2520

aattggaatg cagtaataga tatgtgattt tacatcattt ttaagaaacc aaggggaagt     2580

aataagttga aaaagaaatc cataactatt aaaagatttt aactttttta ttttattaaa     2640

atgcttgcat attttaagta aaattaaaaa tgtttactga atttattttt ttatttgaat     2700

attttgggat tagttacaaa atatttagag attaaataaa taatagcttt gtttgtgtta     2760

gacttcactt ctacttgtat tttctttctt gttaaaagtc tagacaactg agatttactt     2820

actttgaact tgttccaatc caaaagtaag cactaagtct cattttatga gaccaccatt     2880

tcttaatatc acatccagtg cacctttgtc tttctgccat atctgaaata aaactatcag     2940

taattcacat agataaacat aagactaaag aagtatattt acattatctg gagagttttg     3000

ttgcagctac gagtttgtat ggcaaattca ataataaagt attgtttatg caaattgcaa     3060

aaaaaaaaaa aaaaaa                                                     3076


<210>  514
<211>  497
<212>  PRT
<213>  Homo Sapiens

<400>  514

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  515
<211>  3657
<212>  DNA
<213>  Homo Sapiens

<400>  515
agtcgcctcc cagatgagca ctctctcaga ccgctgcggg ccgccaggcg ccgggaatgt       60

cccctgaatg cgcgcgggca gcgggcgacg cgcccttgcg cagcctggag caagccaacc      120

gcacccgctt tcccttcttc tccgacgtca agggcgacca ccggctggtg ctggccgcgg      180

tggagacaac cgtgctggtg ctcatctttg cagtgtcgct gctgggcaac gtgtgcgccc      240

tggtgctggt ggcgcgccga cgacgccgcg gcgcgactgc ctgcctggta ctcaacctct      300

tctgcgcgga cctgctcttc atcagcgcta tccctctggt gctggccgtg cgctggactg      360

aggcctggct gctgggcccc gttgcctgcc acctgctctt ctacgtgatg accctgagcg      420

gcagcgtcac catcctcacg ctggccgcgg tcagcctgga gcgcatggtg tgcatcgtgc      480

acctgcagcg cggcgtgcgg ggtcctgggc ggcgggcgcg ggcagtgctg ctggcgctca      540

tctggggcta ttcggcggtc gccgctctgc ctctctgcgt cttcttccga gtcgtcccgc      600

aacggctccc cggcgccgac caggaaattt cgatttgcac actgatttgg cccaccattc      660

ctggagagat ctcgtgggat gtctcttttg ttactttgaa cttcttggtg ccaggactgg      720

tcattgtgat cagttactcc aaaattttac agacctcgga acacctcctg gatgcaagag      780

ctgtcgtgac tcacagtgag atcacaaagg catcaaggaa gaggctcacg gtaagcctgg      840

cctactcgga gagccaccag atccgcgtgt cccagcagga cttccggctc ttccgcaccc      900

tcttcctcct catggtctcc ttcttcatca tgtggagccc catcatcatc accatcctcc      960

tcatcctgat ccagaacttc aagcaagacc tggtcatctg gccgtccctc ttcttctggg     1020

tggtggcctt cacatttgct aattcagccc taaaccccat cctctacaac atgacactgt     1080

gcaggaatga gtggaagaaa attttttgct gcttctggtt cccagaaaag ggagccattt     1140

taacagacac atctgtcaaa agaaatgact tgtcgattat ttctggctaa tttttcttta     1200

tagccgagtt tctcacacct ggcgagctgt ggcatgcttt taaacagagt tcatttccag     1260

taccctccat cagtgcaccc tgctttaaga aaatgaacct atgcaaatag acatccacag     1320

cgtcggtaaa ttaaggggtg atcaccaagt ttcataatat tttcccttta taaaaggatt     1380

tgttggccag gtgcagtggt tcatgcctgt aatcccagca gtttgggagg ctgaggtggg     1440

tggatcacct gaggtcagga gttcgagacc aacctgacca acatggtgag acccccgtct     1500

ctactaaaaa taaaaaaaaa aattagctgg gagtggtggt gggcacctgt aatcctagct     1560

acttgggagg ctgaaccagg agaatctctt gaacctggga ggcagaggtt gcagtgagcc     1620

gagatcgtgc cattgcactc caaccagggc aacaagagtg aaactccatc ttaaaaaaaa     1680

aaaaaaaaag atttgttatg ggttcctttt aaatgtgaac ttttttagtg tgtttgtaat     1740

atgatcaaat ttaataaata tttatttatg actgttcagc aatcacatct cctacatata     1800

aagccacacc atagtggttt ctgaagtgag tcttagaacc gattcaggac gcagatttct     1860

cctctgaagg gtcacagcca ccctgtgccc taccttggac tcgcaagggt ttaggatcat     1920

tcgttgatgt caagagcaat tgaagaattt ctaaggaaca gttaaagatg acttactttt     1980

tttttttttt catttataaa aatgctatgg acccttttaa gagaatcggc atcatgaaat     2040

gagagagaaa gtaggatggc tctgaaatgt ttgagagtga gttcaggagt ggtttactcc     2100

tgacgcatcc agcagagatg cctcttaagc accagccatg gcagacagtg tcctttgtgc     2160

taggaataca gtggtgaacc agacagccat ggccctctct cagggaactt accttcgagt     2220

caggggcaga aaaactaaat aaaagtcaat aaactatatc tatatacaga tacctatata     2280

tttgagatga gggtcttgct ccaatgccca ggctggagtg caacggcaca atcacggctc     2340

cctgaagcct caaatgcctt ggctcaagca atcctcccgc ctcagcctcc caagtagctg     2400

ggattacagg cgtgagccgc cacgcctggc tacaagtcaa taaatagtat agcatcacag     2460

agcgaataag cactgtgaag aaaatgggac gggggctatg gtagtgatgg gaatttagat     2520

cagatgggga ggggcctaag gagacctttc tgaggagtga caaattggat caaaaggtaa     2580

gcgacaagaa agggccacct gtgtgaatgg gggaagggac acagaagaga tgttagtgca     2640

aggaggctga cacgcttgaa gggagagtgg cgtaagccga ctattgatgg agcctcctct     2700

gcactaggca ctgcctttaa tgctgagatg aggggtaccc ggctggggcc tgtcagttga     2760

ggccagagaa attgcagggt tagatcacat agggcctagg agtttattct gttctccaag     2820

cccctggagg ttggcaactg gaggctgacg tgacctgatg aatgtgtgca aagattaccc     2880

tggctgctgg gcagggaata gactctgagg agcatgagtg aaaatggaga ccagttgggc     2940

agctgctgaa gtgtgacatg gggatgggac cttggaggtg agtggcatta gggagggatt     3000

gtgagaaatg acttgtaaat ataccttggg aaggtaaaac aaagatgatt tattgatggg     3060

aaggatggaa ttgatagaat gtgagggaaa gggagaactc aaggggaata ctctgatttt     3120

ttagcctgtc attggttgga tggtgaagca ggcaacaaaa atgggggggc ctgggcaaag     3180

attagggggg ggggagccaa gagtttcatt tggagctcat cagtttgaaa tctcagtgag     3240

acttccaaat tgaataggca gttggatgca gagatgtgga gcttgggcct ggagatgcac     3300

attgtttgga gatataaatg gtgtttatag acctatggtt ttataataca tcccttggag     3360

agatagagag aaaccagagc caaagaccga acccagggtc actccaccac ttggaggctg     3420

ggccagtggc tggaatgcac agcagcacgg ggcctggtgt atagtaggtg ttcaacaaat     3480

ctttgttgct gaggaaatca gcaccagcag tagtgactgc ttatgcagtt tctggagcag     3540

cttgcttctg aagtcagatt catggatatc acaagctcga agacaaacga acagagatgt     3600

tttgctcact ttagttaata gatttgatca attaaacctg tttttggaag tgaaaaa        3657


<210>  516
<211>  377
<212>  PRT
<213>  Homo Sapiens

<400>  516

Met Ser Pro Glu Cys Ala Arg Ala Ala Gly Asp Ala Pro Leu Arg Ser 
1               5                   10                  15      


Leu Glu Gln Ala Asn Arg Thr Arg Phe Pro Phe Phe Ser Asp Val Lys 
            20                  25                  30          


Gly Asp His Arg Leu Val Leu Ala Ala Val Glu Thr Thr Val Leu Val 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Leu Leu Gly Asn Val Cys Ala Leu Val Leu 
    50                  55                  60                  


Val Ala Arg Arg Arg Arg Arg Gly Ala Thr Ala Cys Leu Val Leu Asn 
65                  70                  75                  80  


Leu Phe Cys Ala Asp Leu Leu Phe Ile Ser Ala Ile Pro Leu Val Leu 
                85                  90                  95      


Ala Val Arg Trp Thr Glu Ala Trp Leu Leu Gly Pro Val Ala Cys His 
            100                 105                 110         


Leu Leu Phe Tyr Val Met Thr Leu Ser Gly Ser Val Thr Ile Leu Thr 
        115                 120                 125             


Leu Ala Ala Val Ser Leu Glu Arg Met Val Cys Ile Val His Leu Gln 
    130                 135                 140                 


Arg Gly Val Arg Gly Pro Gly Arg Arg Ala Arg Ala Val Leu Leu Ala 
145                 150                 155                 160 


Leu Ile Trp Gly Tyr Ser Ala Val Ala Ala Leu Pro Leu Cys Val Phe 
                165                 170                 175     


Phe Arg Val Val Pro Gln Arg Leu Pro Gly Ala Asp Gln Glu Ile Ser 
            180                 185                 190         


Ile Cys Thr Leu Ile Trp Pro Thr Ile Pro Gly Glu Ile Ser Trp Asp 
        195                 200                 205             


Val Ser Phe Val Thr Leu Asn Phe Leu Val Pro Gly Leu Val Ile Val 
    210                 215                 220                 


Ile Ser Tyr Ser Lys Ile Leu Gln Thr Ser Glu His Leu Leu Asp Ala 
225                 230                 235                 240 


Arg Ala Val Val Thr His Ser Glu Ile Thr Lys Ala Ser Arg Lys Arg 
                245                 250                 255     


Leu Thr Val Ser Leu Ala Tyr Ser Glu Ser His Gln Ile Arg Val Ser 
            260                 265                 270         


Gln Gln Asp Phe Arg Leu Phe Arg Thr Leu Phe Leu Leu Met Val Ser 
        275                 280                 285             


Phe Phe Ile Met Trp Ser Pro Ile Ile Ile Thr Ile Leu Leu Ile Leu 
    290                 295                 300                 


Ile Gln Asn Phe Lys Gln Asp Leu Val Ile Trp Pro Ser Leu Phe Phe 
305                 310                 315                 320 


Trp Val Val Ala Phe Thr Phe Ala Asn Ser Ala Leu Asn Pro Ile Leu 
                325                 330                 335     


Tyr Asn Met Thr Leu Cys Arg Asn Glu Trp Lys Lys Ile Phe Cys Cys 
            340                 345                 350         


Phe Trp Phe Pro Glu Lys Gly Ala Ile Leu Thr Asp Thr Ser Val Lys 
        355                 360                 365             


Arg Asn Asp Leu Ser Ile Ile Ser Gly 
    370                 375         


<210>  517
<211>  3161
<212>  DNA
<213>  Homo Sapiens

<400>  517
actgaaaacc cagcgttagt agaaaagttt cttttctttg aatgacagaa ctacagcata       60

atgcgtggct tcaacctgct cctcttctgg ggatgttgtg ttatgcacag ctgggaaggg      120

cacataagac ccacacggaa accaaacaca aagggtaata actgtagaga cagtaccttg      180

tgcccagctt atgccacctg caccaataca gtggacagtt actattgcgc ttgcaaacaa      240

ggcttcctgt ccagcaatgg gcaaaatcac ttcaaggatc caggagtgcg atgcaaagat      300

attgatgaat gttctcaaag cccccagccc tgtggtccta actcatcctg caaaaacctg      360

tcagggaggt acaagtgcag ctgtttagat ggtttctctt ctcccactgg aaatgactgg      420

gtcccaggaa agccgggcaa tttctcctgt actgatatca atgagtgcct caccagcagc      480

gtctgccctg agcattctga ctgtgtcaac tccatgggaa gctacagttg cagctgtcaa      540

gttggattca tctctagaaa ctccacctgt gaagacgtgg atgaatgtgc agatccaaga      600

gcttgcccag agcatgcaac ttgtaataac actgttggaa actactcttg tttctgcaac      660

ccaggatttg aatccagcag tggccacttg agtttccagg gtctcaaagc atcgtgtgaa      720

gatattgatg aatgcactga aatgtgcccc atcaattcaa catgcaccaa cactcctggg      780

agctactttt gcacctgcca ccctggcttt gcaccaagca atggacagtt gaatttcaca      840

gaccaaggag tggaatgtag agatattgat gagtgccgcc aagatccatc aacctgtggt      900

cctaattcta tctgcaccaa tgccctgggc tcctacagct gtggctgcat tgcaggcttt      960

catcccaatc cagaaggctc ccagaaagat ggcaacttca gctgccaaag ggttctcttc     1020

aaatgtaagg aagatgtgat acccgataat aagcagatcc agcaatgcca agagggaacc     1080

gcagtgaaac ctgcatatgt ctccttttgt gcacaaataa ataacatctt cagcgttctg     1140

gacaaagtgt gtgaaaataa aacgaccgta gtttctctga agaatacaac tgagagcttt     1200

gtccctgtgc ttaaacaaat atccacgtgg actaaattca ccaaggaaga gacgtcctcc     1260

ctggccacag tcttcctgga gagtgtggaa agcatgacac tggcatcttt ttggaaaccc     1320

tcagcaaata tcactccggc tgttcggacg gaatacttag acattgagag caaagttatc     1380

aacaaagaat gcagtgaaga gaatgtgacg ttggacttgg tagccaaggg ggataagatg     1440

aagatcgggt gttccacaat tgaggaatct gaatccacag agaccactgg tgtggctttt     1500

gtctcctttg tgggcatgga atcggtttta aatgagcgct tcttcaaaga ccaccaggct     1560

cccttgacca cctctgagat caagctgaag atgaattctc gagtcgttgg gggcataatg     1620

actggagaga agaaagacgg cttctcagat ccaatcatct acactctgga gaacattcag     1680

ccaaagcaga agtttgagag gcccatctgt gtttcctgga gcactgatgt gaagggtgga     1740

agatggacat cctttggctg tgtgatcctg gaagcttctg agacatatac catctgcagc     1800

tgtaatcaga tggcaaatct tgccgttatc atggcgtctg gggagctcac gatggacttt     1860

tccttgtaca tcattagcca tgtaggcatt atcatctcct tggtgtgcct cgtcttggcc     1920

atcgccacct ttctgctgtg tcgctccatc cgaaatcaca acacctacct ccacctgcac     1980

ctctgcgtgt gtctcctctt ggcgaagact ctcttcctcg ccggtataca caagactgac     2040

aacaagatgg gctgcgccat catcgcgggc ttcctgcact accttttcct tgcctgcttc     2100

ttctggatgc tggtggaggc tgtgatactg ttcttgatgg tcagaaacct gaaggtggtg     2160

aattacttca gctctcgcaa catcaagatg ctgcacatct gtgcctttgg ttatgggctg     2220

ccgatgctgg tggtggtgat ctctgccagt gtgcagccac agggctatgg aatgcataat     2280

cgctgctggc tgaatacaga gacagggttc atctggagtt tcttggggcc agtttgcaca     2340

gttatagtga tcaactccct tctcctgacc tggaccttgt ggatcctgag gcagaggctt     2400

tccagtgtta atgccgaagt ctcaacgcta aaagacacca ggttactgac cttcaaggcc     2460

tttgcccagc tcttcatcct gggctgctcc tgggtgctgg gcatttttca gattggacct     2520

gtggcaggtg tcatggctta cctgttcacc atcatcaaca gcctgcaggg ggccttcatc     2580

ttcctcatcc actgtctgct caacggccag gtacgagaag aatacaagag gtggatcact     2640

gggaagacga agcccagctc ccagtcccag acctcaagga tcttgctgtc ctccatgcca     2700

tccgcttcca agacgggtta aagtcctttc ttgctttcaa atatgctatg gagccacagt     2760

tgaggacagt agtttcctgc aggagcctac cctgaaatct cttctcagct taacatggaa     2820

atgaggatcc caccagcccc agaaccctct ggggaagaat gttgggggcg gtcttcctgt     2880

ggttgtatgc actgatgaga aatcaggcgt ttctgctcca aacgaccatt ttatcttcgt     2940

gctctgcaac ttcttcaatt ccagagtttc tgagaacaga cccaaattca atggcatgac     3000

caagaacacc tggctaccat tttgttttct cctgcccttg ttggtgcatg gttctaagca     3060

tgcccctcca gagcctatca tacgcctgat acagagaacc tctcaataaa tgatttgtcg     3120

cctgtctgac tgatttaccc taggaaaaaa aaaaaaaaaa a                         3161


<210>  518
<211>  886
<212>  PRT
<213>  Homo Sapiens

<400>  518

Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Thr Arg Lys Pro Asn Thr Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Thr Leu Cys Pro Ala Tyr Ala Thr Cys Thr 
        35                  40                  45              


Asn Thr Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Thr Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Thr Asp Ile Asn Glu Cys Leu Thr Ser Ser Val Cys Pro Glu 
    130                 135                 140                 


His Ser Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln 
145                 150                 155                 160 


Val Gly Phe Ile Ser Arg Asn Ser Thr Cys Glu Asp Val Asp Glu Cys 
                165                 170                 175     


Ala Asp Pro Arg Ala Cys Pro Glu His Ala Thr Cys Asn Asn Thr Val 
            180                 185                 190         


Gly Asn Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly 
        195                 200                 205             


His Leu Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu 
    210                 215                 220                 


Cys Thr Glu Met Cys Pro Ile Asn Ser Thr Cys Thr Asn Thr Pro Gly 
225                 230                 235                 240 


Ser Tyr Phe Cys Thr Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln 
                245                 250                 255     


Leu Asn Phe Thr Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys 
            260                 265                 270         


Arg Gln Asp Pro Ser Thr Cys Gly Pro Asn Ser Ile Cys Thr Asn Ala 
        275                 280                 285             


Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro 
    290                 295                 300                 


Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe 
305                 310                 315                 320 


Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys 
                325                 330                 335     


Gln Glu Gly Thr Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln 
            340                 345                 350         


Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Thr 
        355                 360                 365             


Thr Val Val Ser Leu Lys Asn Thr Thr Glu Ser Phe Val Pro Val Leu 
    370                 375                 380                 


Lys Gln Ile Ser Thr Trp Thr Lys Phe Thr Lys Glu Glu Thr Ser Ser 
385                 390                 395                 400 


Leu Ala Thr Val Phe Leu Glu Ser Val Glu Ser Met Thr Leu Ala Ser 
                405                 410                 415     


Phe Trp Lys Pro Ser Ala Asn Ile Thr Pro Ala Val Arg Thr Glu Tyr 
            420                 425                 430         


Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn 
        435                 440                 445             


Val Thr Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys 
    450                 455                 460                 


Ser Thr Ile Glu Glu Ser Glu Ser Thr Glu Thr Thr Gly Val Ala Phe 
465                 470                 475                 480 


Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys 
                485                 490                 495     


Asp His Gln Ala Pro Leu Thr Thr Ser Glu Ile Lys Leu Lys Met Asn 
            500                 505                 510         


Ser Arg Val Val Gly Gly Ile Met Thr Gly Glu Lys Lys Asp Gly Phe 
        515                 520                 525             


Ser Asp Pro Ile Ile Tyr Thr Leu Glu Asn Ile Gln Pro Lys Gln Lys 
    530                 535                 540                 


Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Thr Asp Val Lys Gly Gly 
545                 550                 555                 560 


Arg Trp Thr Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Thr Tyr 
                565                 570                 575     


Thr Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala 
            580                 585                 590         


Ser Gly Glu Leu Thr Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val 
        595                 600                 605             


Gly Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile Ala Thr Phe 
    610                 615                 620                 


Leu Leu Cys Arg Ser Ile Arg Asn His Asn Thr Tyr Leu His Leu His 
625                 630                 635                 640 


Leu Cys Val Cys Leu Leu Leu Ala Lys Thr Leu Phe Leu Ala Gly Ile 
                645                 650                 655     


His Lys Thr Asp Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu 
            660                 665                 670         


His Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val 
        675                 680                 685             


Ile Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser 
    690                 695                 700                 


Ser Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu 
705                 710                 715                 720 


Pro Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr 
                725                 730                 735     


Gly Met His Asn Arg Cys Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp 
            740                 745                 750         


Ser Phe Leu Gly Pro Val Cys Thr Val Ile Val Ile Asn Ser Leu Leu 
        755                 760                 765             


Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn 
    770                 775                 780                 


Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala 
785                 790                 795                 800 


Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe 
                805                 810                 815     


Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile 
            820                 825                 830         


Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn 
        835                 840                 845             


Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys 
    850                 855                 860                 


Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro 
865                 870                 875                 880 


Ser Ala Ser Lys Thr Gly 
                885     


<210>  519
<211>  1867
<212>  DNA
<213>  Homo Sapiens

<400>  519
cacatagctc agttcccata aaagggctgg tttgccgcgt cggggagtgg agtgggacag       60

gtatataaag gaagtacagg gcctggggaa gaggccctgt ctaggtagct ggcaccagga      120

gccgtgggca agggaagagg ccacaccctg ccctgctctg ctgcagccag aatgggtgtg      180

aaggcgtctc aaacaggctt tgtggtcctg gtgctgctcc agtgctgctc tgcatacaaa      240

ctggtctgct actacaccag ctggtcccag taccgggaag gcgatgggag ctgcttccca      300

gatgcccttg accgcttcct ctgtacccac atcatctaca gctttgccaa tataagcaac      360

gatcacatcg acacctggga gtggaatgat gtgacgctct acggcatgct caacacactc      420

aagaacagga accccaacct gaagactctc ttgtctgtcg gaggatggaa ctttgggtct      480

caaagatttt ccaagatagc ctccaacacc cagagtcgcc ggactttcat caagtcagta      540

ccgccatttc tgcgcaccca tggctttgat gggctggacc ttgcctggct ctaccctgga      600

cggagagaca aacagcattt taccacccta atcaaggaaa tgaaggccga atttataaag      660

gaagcccagc cagggaaaaa gcagctcctg ctcagcgcag cactgtctgc ggggaaggtc      720

accattgaca gcagctatga cattgccaag atatcccaac acctggattt cattagcatc      780

atgacctacg attttcatgg agcctggcgt gggaccacag gccatcacag tcccctgttc      840

cgaggtcagg aggatgcaag tcctgacaga ttcagcaaca ctgactatgc tgtggggtac      900

atgttgaggc tgggggctcc tgccagtaag ctggtgatgg gcatccccac cttcgggagg      960

agcttcactc tggcttcttc tgagactggt gttggagccc caatctcagg accgggaatt     1020

ccaggccggt tcaccaagga ggcagggacc cttgcctact atgagatctg tgacttcctc     1080

cgcggagcca cagtccatag aatcctcggc cagcaggtcc cctatgccac caagggcaac     1140

cagtgggtag gatacgacga ccaggaaagc gtcaaaagca aggtgcagta cctgaaggac     1200

aggcagctgg cgggcgccat ggtatgggcc ctggacctgg atgacttcca gggctccttc     1260

tgcggccagg atctgcgctt ccctctcacc aatgccatca aggatgcact cgctgcaacg     1320

tagccctctg ttctgcacac agcacggggg ccaaggatgc cccgtccccc tctggctcca     1380

gctggccggg agcctgatca cctgccctgc tgagtcccag gctgagcctc agtctccctc     1440

ccttggggcc tatgcagagg tccacaacac acagatttga gctcagccct ggtgggcaga     1500

gaggtaggga tggggctgtg gggatagtga ggcatcgcaa tgtaagactc gggattagta     1560

cacacttgtt gattaatgga aatgtttaca gatccccaag cctggcaagg gaatttcttc     1620

aactccctgc cccccagccc tccttatcaa aggacaccat tttggcaagc tctatcacca     1680

aggagccaaa catcctacaa gacacagtga ccatactaat tataccccct gcaaagccca     1740

gcttgaaacc ttcacttagg aacgtaatcg tgtcccctat cctacttccc cttcctaatt     1800

ccacagctgc tcaataaagt acaagagctt aacagtgaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaa                                                               1867


<210>  520
<211>  383
<212>  PRT
<213>  Homo Sapiens

<400>  520

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  521
<211>  3327
<212>  DNA
<213>  Homo Sapiens

<400>  521
ggaagaggag gggggagaag gaggagctga agcgggaaga gcggcaggca gcggctcggc       60

ggagttgcag cagaggcggc ggcgacgctg agacaccgca gcttccctga gcgccgagtc      120

cctccgggga cagcagcagg gagcgcccgc gcagccaccg agcctctgcc cagccaagcc      180

gccgtcgccg cgccggggga ccgccagcca tggccgcgcc gggggatccg caggacgagc      240

tgctgccgct ggccggcccc gggtcccagt ggctcaggca ccggggggag ggggagaacg      300

aagcggtgac gccgaaaggg gccacgccgg cgccgcaggc tggggagccc agcccggggt      360

tgggcgccag ggcccgggaa gcggcgtcgc gggaagccgg ctcgggcccc gcccggcagt      420

cgcccgttgc catggaaact gcatccacag gtgtggcagg tgtttccagt gccatggacc      480

acaccttctc aacaacatca aaagatgggg aaggatcgtg ttacacatct ctcatttctg      540

acatctgcta tccacctcag gaggattcta catattttac tggaattctt cagaaggaaa      600

atggccacgt caccatttca gagagccctg aggagctggg tacacccggc ccctccttac      660

cagatgtgcc tgggatagag tctcgtggct tatttagttc tgattctgga atagagatga      720

ctcctgcaga gtccacggaa gtgaacaaga tcttagcaga ccctctggac cagatgaaag      780

cagaggccta taaatacatt gacataacca gacccgagga ggtgaagcac caagaacaac      840

atcaccccga gctggaagat aaagacttgg actttaagaa taaagacact gacatctcaa      900

ttaaacctga aggagtccgt gaacctgaca aaccagctcc tgtggaggga aaaatcatca      960

aggaccattt attggaagaa tccacatttg ctccatacat agatgatctc tctgaagaac     1020

agcgcagggc tcctcagatc accacccctg tcaaaatcac actgacggaa atagaacctt     1080

ctgttgaaac cactacccaa gagaagaccc ctgagaagca agatatatgt ctaaagccaa     1140

gtcctgacac agtccccact gtcactgtct cggagcctga agacgacagc ccaggatcta     1200

tcacccctcc atcttctgga acagaaccat ctgctgcaga atcccagggg aaaggcagca     1260

tctccgagga tgagctgatc accgccatca aagaagcaaa gggattatcg tatgaaaccg     1320

ccgagaaccc acggccggtg ggccagctgg ccgacaggcc cgaggtcaag gccaggtccg     1380

gaccgccaac catccccagc cccctggacc acgaggccag cagcgcggag tcgggggact     1440

cagagatcga gctggtgtcc gaggacccca tggccgcgga ggacgcgctg ccctcaggct     1500

atgtgagctt tggccacgtg ggcggcccgc cgccctcgcc cgcctcgcca tccatccagt     1560

acagcatcct gagggaggag cgcgaggccg agctggacag cgagctcatc atcgagtcgt     1620

gcgacgcctc ctcggcctcg gaggagagcc ccaagcggga gcaggactca cccccgatga     1680

agcccagcgc cctggatgcc atccgggagg agactggcgt ccgggccgag gagcgtgcgc     1740

caagccggcg gggcctggcc gagccgggtt ccttcctcga ctacccctca actgagcccc     1800

agcctggccc cgagctgccc cctggagacg gagccctgga gcctgagacg cccatgttgc     1860

cacggaagcc tgaagaagac tcgagttcca accaaagtcc tgcggccaca aagggccctg     1920

ggcctctagg tcctggcgcc ccgcccccac tgctgtttct caataagcaa aaagctattg     1980

acctgttgta ttggcgggac atcaagcaga cgggcatcgt gtttgggagt ttcctgctgc     2040

tgctcttctc cctgacccag ttcagcgtgg tgagcgtcgt ggcctacctg gccctggccg     2100

cactctcagc caccatcagt ttccgcatct acaagtctgt tttacaagca gtgcagaaaa     2160

ccgacgaagg ccaccctttc aaggcctact tggagcttga gatcaccctt tctcaggagc     2220

agattcagaa gtacacggac tgcctgcagt tctacgtgaa cagcacactt aaggaactga     2280

ggaggctctt ccttgtccag gacctggtgg attccttaaa atttgcagtc ctgatgtggc     2340

tcctgaccta cgttggcgct ctcttcaatg gcctgaccct gctgctcatg gctgtggttt     2400

caatgtttac tctacctgta gtgtatgtta agcaccaggc acagattgac caatatctgg     2460

gacttgtgag gactcacata aatgctgttg tggcaaagat tcaggctaaa atcccaggcg     2520

ctaagaggca cgctgagtaa actgatttcc caccggggac tggacacaaa caggaatgtc     2580

tggagtggta acagctctct tcttactcat tactgcaaat tgattgtctt tcccccctcc     2640

ctccagtacc ataatcttag agacaaacct taaaacagct gtttttaggc tgttccttgt     2700

actcttagga tatttgagtc acttgtgtca accactaaag tatagagaaa agtgtattag     2760

atgtggtttt taattttgtg ttgctaaaaa aagtgcatga tggtgagagc ccaagttatc     2820

tttccctctt cggtgttctt cttctcttct ctgcaatgct tctgtagctt ctaatgttcc     2880

ccgtggctag gcctttcctg ccgagtgctc tgatgcaata gtggaaatcg cttatatgtc     2940

cttgggttgc tggttggatt aatctttaat aacaatatat agaattgtag actgatgttt     3000

tagcattttt ccaacacaca caacgtaaaa ataaaagcag tcgaccgcac ttatggtaat     3060

cagttttgta taacttaaaa taattaaata aatgaataaa tccaaaacaa acatgcagta     3120

cttttgttgt atgggattgg tgggctgatt tacatgtatg gttactaaaa agtaccagca     3180

tgttaacttt attacaattt gtattacttt ctctgtagtt cctaatggat tcaattacgg     3240

actctggata tttgcactta tgtacttgat actgaatgca taaataaatg ttactaaatg     3300

tagaatgtta aaaaaaaaaa aaaaaaa                                         3327


<210>  522
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  522

Met Ala Ala Pro Gly Asp Pro Gln Asp Glu Leu Leu Pro Leu Ala Gly 
1               5                   10                  15      


Pro Gly Ser Gln Trp Leu Arg His Arg Gly Glu Gly Glu Asn Glu Ala 
            20                  25                  30          


Val Thr Pro Lys Gly Ala Thr Pro Ala Pro Gln Ala Gly Glu Pro Ser 
        35                  40                  45              


Pro Gly Leu Gly Ala Arg Ala Arg Glu Ala Ala Ser Arg Glu Ala Gly 
    50                  55                  60                  


Ser Gly Pro Ala Arg Gln Ser Pro Val Ala Met Glu Thr Ala Ser Thr 
65                  70                  75                  80  


Gly Val Ala Gly Val Ser Ser Ala Met Asp His Thr Phe Ser Thr Thr 
                85                  90                  95      


Ser Lys Asp Gly Glu Gly Ser Cys Tyr Thr Ser Leu Ile Ser Asp Ile 
            100                 105                 110         


Cys Tyr Pro Pro Gln Glu Asp Ser Thr Tyr Phe Thr Gly Ile Leu Gln 
        115                 120                 125             


Lys Glu Asn Gly His Val Thr Ile Ser Glu Ser Pro Glu Glu Leu Gly 
    130                 135                 140                 


Thr Pro Gly Pro Ser Leu Pro Asp Val Pro Gly Ile Glu Ser Arg Gly 
145                 150                 155                 160 


Leu Phe Ser Ser Asp Ser Gly Ile Glu Met Thr Pro Ala Glu Ser Thr 
                165                 170                 175     


Glu Val Asn Lys Ile Leu Ala Asp Pro Leu Asp Gln Met Lys Ala Glu 
            180                 185                 190         


Ala Tyr Lys Tyr Ile Asp Ile Thr Arg Pro Glu Glu Val Lys His Gln 
        195                 200                 205             


Glu Gln His His Pro Glu Leu Glu Asp Lys Asp Leu Asp Phe Lys Asn 
    210                 215                 220                 


Lys Asp Thr Asp Ile Ser Ile Lys Pro Glu Gly Val Arg Glu Pro Asp 
225                 230                 235                 240 


Lys Pro Ala Pro Val Glu Gly Lys Ile Ile Lys Asp His Leu Leu Glu 
                245                 250                 255     


Glu Ser Thr Phe Ala Pro Tyr Ile Asp Asp Leu Ser Glu Glu Gln Arg 
            260                 265                 270         


Arg Ala Pro Gln Ile Thr Thr Pro Val Lys Ile Thr Leu Thr Glu Ile 
        275                 280                 285             


Glu Pro Ser Val Glu Thr Thr Thr Gln Glu Lys Thr Pro Glu Lys Gln 
    290                 295                 300                 


Asp Ile Cys Leu Lys Pro Ser Pro Asp Thr Val Pro Thr Val Thr Val 
305                 310                 315                 320 


Ser Glu Pro Glu Asp Asp Ser Pro Gly Ser Ile Thr Pro Pro Ser Ser 
                325                 330                 335     


Gly Thr Glu Pro Ser Ala Ala Glu Ser Gln Gly Lys Gly Ser Ile Ser 
            340                 345                 350         


Glu Asp Glu Leu Ile Thr Ala Ile Lys Glu Ala Lys Gly Leu Ser Tyr 
        355                 360                 365             


Glu Thr Ala Glu Asn Pro Arg Pro Val Gly Gln Leu Ala Asp Arg Pro 
    370                 375                 380                 


Glu Val Lys Ala Arg Ser Gly Pro Pro Thr Ile Pro Ser Pro Leu Asp 
385                 390                 395                 400 


His Glu Ala Ser Ser Ala Glu Ser Gly Asp Ser Glu Ile Glu Leu Val 
                405                 410                 415     


Ser Glu Asp Pro Met Ala Ala Glu Asp Ala Leu Pro Ser Gly Tyr Val 
            420                 425                 430         


Ser Phe Gly His Val Gly Gly Pro Pro Pro Ser Pro Ala Ser Pro Ser 
        435                 440                 445             


Ile Gln Tyr Ser Ile Leu Arg Glu Glu Arg Glu Ala Glu Leu Asp Ser 
    450                 455                 460                 


Glu Leu Ile Ile Glu Ser Cys Asp Ala Ser Ser Ala Ser Glu Glu Ser 
465                 470                 475                 480 


Pro Lys Arg Glu Gln Asp Ser Pro Pro Met Lys Pro Ser Ala Leu Asp 
                485                 490                 495     


Ala Ile Arg Glu Glu Thr Gly Val Arg Ala Glu Glu Arg Ala Pro Ser 
            500                 505                 510         


Arg Arg Gly Leu Ala Glu Pro Gly Ser Phe Leu Asp Tyr Pro Ser Thr 
        515                 520                 525             


Glu Pro Gln Pro Gly Pro Glu Leu Pro Pro Gly Asp Gly Ala Leu Glu 
    530                 535                 540                 


Pro Glu Thr Pro Met Leu Pro Arg Lys Pro Glu Glu Asp Ser Ser Ser 
545                 550                 555                 560 


Asn Gln Ser Pro Ala Ala Thr Lys Gly Pro Gly Pro Leu Gly Pro Gly 
                565                 570                 575     


Ala Pro Pro Pro Leu Leu Phe Leu Asn Lys Gln Lys Ala Ile Asp Leu 
            580                 585                 590         


Leu Tyr Trp Arg Asp Ile Lys Gln Thr Gly Ile Val Phe Gly Ser Phe 
        595                 600                 605             


Leu Leu Leu Leu Phe Ser Leu Thr Gln Phe Ser Val Val Ser Val Val 
    610                 615                 620                 


Ala Tyr Leu Ala Leu Ala Ala Leu Ser Ala Thr Ile Ser Phe Arg Ile 
625                 630                 635                 640 


Tyr Lys Ser Val Leu Gln Ala Val Gln Lys Thr Asp Glu Gly His Pro 
                645                 650                 655     


Phe Lys Ala Tyr Leu Glu Leu Glu Ile Thr Leu Ser Gln Glu Gln Ile 
            660                 665                 670         


Gln Lys Tyr Thr Asp Cys Leu Gln Phe Tyr Val Asn Ser Thr Leu Lys 
        675                 680                 685             


Glu Leu Arg Arg Leu Phe Leu Val Gln Asp Leu Val Asp Ser Leu Lys 
    690                 695                 700                 


Phe Ala Val Leu Met Trp Leu Leu Thr Tyr Val Gly Ala Leu Phe Asn 
705                 710                 715                 720 


Gly Leu Thr Leu Leu Leu Met Ala Val Val Ser Met Phe Thr Leu Pro 
                725                 730                 735     


Val Val Tyr Val Lys His Gln Ala Gln Ile Asp Gln Tyr Leu Gly Leu 
            740                 745                 750         


Val Arg Thr His Ile Asn Ala Val Val Ala Lys Ile Gln Ala Lys Ile 
        755                 760                 765             


Pro Gly Ala Lys Arg His Ala Glu 
    770                 775     


<210>  523
<211>  3241
<212>  DNA
<213>  Homo Sapiens

<400>  523
gtgcagggcg gggctggcct gcggaagggg gcgggttcgg aggagtgaac tgtgcggtta       60

gtgcgccttt cagcctcacc tgcagctgcg cctccttgca cctgcgcctg tgctttttct      120

cccagcactg cggacgcgac tcgagggtga cgctcgctcc gctcgtcccg ctcgtcatgg      180

cctacccggg atacggagga gggtttggaa attttagcat tcaggtgcca ggaatgcaga      240

tgggacagcc agtgccagaa acaggcccag ctatactcct cgatggatac tctgggccag      300

catattcaga cacttattcc tcagctggtg actccgtgta tacttacttc agtgctgttg      360

ctggacagga tggtgaagtg gatgctgaag aacttcagag atgtttgaca cagtctggaa      420

ttaatggaac ttactctccc ttcagtttgg aaacctgcag aattatgatt gccatgttgg      480

atagagatca cacaggaaaa atgggattta atgcattcaa agagctatgg gcagctctta      540

atgcctggaa ggaaaacttc atgactgttg atcaagatgg aagtggcaca gtagaacatc      600

atgagttgcg tcaagccatt ggtcttatgg gttataggtt gagtcctcaa acattaacta      660

ctattgttaa acgttatagc aagaatggca gaattttctt tgatgattat gttgcttgct      720

gtgtgaagct tcgagcattg acagatttct ttaggaaaag agaccacttg caacaagggt      780

ctgcgaattt catatatgac gattttttgc agggcactat ggcaatttga atgcttagaa      840

ttttaaacct gaagagacac tgtgaattct tttgtttgga agaagtgaac tggactactt      900

taaaactttt aagggttttc tatgttcttc ctacctgtta aacctcttcc ctttctgtgt      960

gtttttattt tagcagatag ttcaaagcaa taaaagattt cttttttaat ttgaggtatt     1020

actgcttttg gaaaagttat tttataaata tgtgcatatt gtcataaaat attgtatgat     1080

taattgattt aaataatgct tagccttaat tttagataat gtaaatttag aggaatgtac     1140

tttacaagat agattgtata agaagccaaa taatgaaagc ctagaaaaaa ctaatttata     1200

cttatctgaa ggttacaaat tagactttta aattttcttt gtagttggtg gtgtttgagg     1260

gttggctaga aatgaaagcc tggattttgt gccatgtttg taatatagtt tgttccttga     1320

tcaaataatc agagaaaaga aacttaaaga tctttgtctg tgaagaagaa aattatctcc     1380

ctagttcaat ctgtagtgaa ataagactac agaaggcatt gttttttcct tttttatttt     1440

ttgtattata tatttttctt aaatatgttt tattgtcttc tctaagcaaa aagttcttaa     1500

taaacatagt atttctctct gcgtcctatt tcattagtga agacatagtt cacctaaaat     1560

ggcatcctgc tctgaatcta gactttttag aaatggcata tgtttttgat gatatgtcaa     1620

cattcaaaat tgtcctaatt aaattgttgt ttaaatgtaa tgtcaactct ttataaactt     1680

aaaaataaac aagtaattaa ccactctaat tgttcagaaa ttttacattt gacttatttg     1740

acaacattaa cattagtggt ggctttgcca ttaaaaaccc agtaagtatt ttgagtgcat     1800

ctatgtgatg tggtgttttg agcatagtag gcaccacagc aacttttctg cgtggtacta     1860

aaactgccga aaatgcgacg tagaatcacc agatctttag tgtttaatat ccctggtata     1920

agatgttata attaatgtaa tttctttctt ggcaaacacc tcatgtctgt cttagtgaag     1980

atttaataaa ccacttattt ttcttatgct ttaaatgtgt attttctaac ctaacagtga     2040

gtgacataat tttatgactg ctgaccaaat taatttatag attttataaa atcccatgtt     2100

tcttaatgga tggaggatag atggcaatat cttgaacaaa atcttttata aacttacaga     2160

attttaaatc agccttcact taaaaaaatc ctggaaagga agtaacgcat agtcacttga     2220

cactgataat tttatataat ttgctgtcaa attcacttgg tcagttttat aaaaatgtgt     2280

gaataggtaa tacacataat tttgttctct ggctttttta tgaacatata tttgataatg     2340

tgagaggaca ttaactgagc tgggaaatta aagaaacaga attctaatta gaagtgttgt     2400

aggaaaaagc aaatgtgaaa acactaagtg tcgttcacat cgaatggtga taatgtcgct     2460

cagcaacctg taatcttaac atccaggtta tacagatggt cgttactgaa ctattctgcg     2520

gtcgattatg attatctctc ttacttggag gctcacagtt gaggtaaaac ttttaaaatg     2580

acaaatggta ttattcatgt aagcttctgc caggtgacac tctatattag aactctttaa     2640

cacaattttc atttaaaaat gttcttatga cttttggtca tagaaggtct atgaaggagc     2700

ttccatggcc aaacatattt agaaactctc actttctaaa gcttgacaag gtatattagc     2760

atctgaaacc ccaaggttaa taaaatcagt catgtttaat tttatttgac ccagtttttt     2820

ccaaactttt tgaccacaga acccctttct ctagcaaaac ctaacattct atgccgatcc     2880

aacttaattg ccaggcaact cttctgcact ttacattaaa cagacaaact tatgttaaca     2940

aaaacattag gcctagagaa tattttacca gaatttttat actgaaatac agttcacttt     3000

ttcgatgctt taaaaataac tgatattttt atgatgaaca tgactgtaat atgaatatag     3060

tatagtagtt tgcactggtt aacttacacc ccagttcttt tacgatgatg taaattattg     3120

aataatgtac actcttaatg tataagtgct tttatttata cagtaaacat gtttccatgt     3180

cattttgaga atttttttaa taaacattca aatagcttgc tgtaaaaaaa aaaaaaaaaa     3240

a                                                                     3241


<210>  524
<211>  217
<212>  PRT
<213>  Homo Sapiens

<400>  524

Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln 
1               5                   10                  15      


Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala 
            20                  25                  30          


Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser 
        35                  40                  45              


Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln 
    50                  55                  60                  


Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser 
65                  70                  75                  80  


Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile 
                85                  90                  95      


Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn 
            100                 105                 110         


Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe 
        115                 120                 125             


Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu 
    130                 135                 140                 


Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu 
145                 150                 155                 160 


Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp 
                165                 170                 175     


Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe 
            180                 185                 190         


Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp 
        195                 200                 205             


Asp Phe Leu Gln Gly Thr Met Ala Ile 
    210                 215         


<210>  525
<211>  4284
<212>  DNA
<213>  Homo Sapiens

<400>  525
cggggccgtg gccgaggcct gcgcgccgcc cggccgcctg cactgcgcgc gcgcccaccc       60

cgcgtgggag gcagcgggag gggcccggag aggtgtggag cggcgcggcg ggaggctccg      120

tgggcggcca cgggagacag cgccggcggg agcgcgcctc tcggcctttc ctccgcgccc      180

ccgcgtcccc agccggccgc tccgagagga cccggaggag gcaggtggct ttctagaaga      240

tgaccataga ggaccttcca gattttccat tagaaggaaa tcctttgttt ggaagatacc      300

catttatatt ttctgcttct gataccccag ttatcttttc catttctgca gcaccaatgc      360

cttcagactg tgaattttct ttctttgatc ctaatgatgc atcatgccag gaaattcttt      420

ttgatcccaa aacttcagtt tcagaattat ttgccatttt gagacagtgg gttcctcagg      480

tccaacaaaa cattgacatt attggaaatg agattcttaa gagaggttgc aatgtgaatg      540

atagagatgg attgacagat atgactcttt tacattatac ctgcaaatct ggagctcatg      600

gtattggtga tgtggaaaca gctgtaaaat ttgcaactca gcttattgac ctgggagcag      660

acattagttt gcggagtcgc tggacaaaca tgaatgcttt gcattatgct gcttattttg      720

atgtccctga acttataaga gtgattttga aaacatcgaa accaaaagat gtggatgcca      780

cttgcagtga ttttaatttt ggaacagctt tgcatattgc agcatacaac ttgtgtgcag      840

gtgctgtgaa gtgcctcttg gagcagggag caaatcctgc atttaggaat gacaaaggac      900

agatccctgc tgatgttgtt ccagacccag tagatatgcc gttagagatg gctgacgccg      960

cagccactgc taaggaaatc aagcagatgc ttctagatgc ggtgcctctg tcatgtaaca     1020

tctcaaaggc catgctccca aattatgatc atgtcactgg caaggcaatg cttacgtcac     1080

ttggcctgaa gttgggggat cgtgttgtta ttgcaggaca gaaggttggt acattaagat     1140

tttgtggaac aactgaattt gcaagtgggc agtgggctgg cattgaactg gatgaaccag     1200

aaggaaaaaa taatggaagt gttggaaaag tccagtactt taaatgtgcc cccaagtatg     1260

gtatttttgc acctctttca aagataagta aagcaaaagg tcgaaggaag aatataacac     1320

acactccttc tacaaaagct gctgtacctc tcatcaggtc ccagaaaatt gacgtagctc     1380

atgtgacgtc aaaagtaaat actggattaa tgacatcaaa aaaagatagt gcttctgagt     1440

caacactttc attgcctcct ggtgaagaac ttaaaactgt gacagagaaa gatgttgccc     1500

tgcttggatc tgtcagcagc tgctcctcta catcttcttt ggaacacaga cagagctacc     1560

ccaagaaaca gaatgcaatc agcagtaaca agaagacaat gagcaaaagc ccttcccttt     1620

catccagagc cagtgctggt ttgaattcct cagcaacatc tacagcaaat aatagccgtt     1680

gcgaggggga actccgcctc ggagagagag tgttagtggt aggacagaga ctgggcacca     1740

ttaggttctt tgggacaaca aacttcgctc caggatattg gtatggtata gagcttgaaa     1800

aaccccatgg caagaatgat ggttcagttg gaggtgtgca gtattttagc tgttctccaa     1860

gatatggaat atttgctccc ccatccaggg tgcaaagagt aacagattcc ctggataccc     1920

tttcagaaat ttcttcaaat aaacagaacc attcttatcc tggttttagg agaagtttta     1980

gcacaacttc tgcttcttcc caaaaggaga ttaacagaag aaatgctttt tccaaatcga     2040

aagctgcttt gcgtcgcagt tggagcagca cccccaccgc aggtggcatt gaagggagcg     2100

tgaagctgca cgaggggtct caggtcctgc tcacgagctc caatgagatg ggtactgtta     2160

ggtatgtggg ccccactgac tttgcttcag gtatctggct tggacttgag ctccgaagcg     2220

ccaagggaaa aaatgatggg tcagtgggtg acaagcgcta tttcacctgt aagccgaacc     2280

atggagtctt agttcgaccg agcagagtga cctatcgggg aattaatggg tcaaaacttg     2340

tggatgagaa ttgttaagct tctaaaatat taaataagct caaatatata tatttggtgt     2400

aaataaagag tccatggtaa atggtttact ttatttagcc atattaaaat tttgaaaata     2460

tagttatctt cttaaaaacc attataacaa ttcagagaga gttctttaca aagccatgaa     2520

tatgaactat ggggaatcat ggttctttta aagcaatttt caaaataagt accaattaaa     2580

gctttaggtt ccaagaagat tctgggactc aggaagaaaa agtgccatca ggtgaccagc     2640

tgttgcattt cttgcttatt ctgttttgtt tttgcacatc ataatggatt tttcttagtg     2700

ccctaattgt gaagggtttc tctagctttg gttatgtgta atgttcacgt gacctttttt     2760

tgtcaatcat ttttggaatt tttctttctt tctgtgcttt attactaata agtccaatga     2820

gtgagtagta gctagatgac tagtatgtag ttttatattt tggtaaaatt atttgccctt     2880

tcagaaatgc ctcatctaaa gatacatgat aattttggag ttggaagggg ccttagaggc     2940

tctccagctc tgcttcttgc ccattgccaa atactgaaat ggaagcccgt cttacctggg     3000

gtcactaact ggttggttaa ctgagctaag aatagactgt gggtctcctc acttgtggcc     3060

cagtgctctt tctgctatac aaaatgtcta atctcagatt tttcttctgc tgcttgactg     3120

cttcatctgg atgaactaca aaaaacccat gattaaggtt tatgaattca agtaataatt     3180

agattttttt tgcacagact tacttaactt ccttattgga tatgtttgta acacataaac     3240

acaaagcact tttcaaacat gatgcacttt tatctttgtg aataatttac tgtcctttcc     3300

tcctgggata tgagaaacat tttaaaaaac gtatttaaca gaagagagca aataaagata     3360

tatcaggaag gatgtattag ttatttactt aaatgtttat aatatctgga ttttttttgt     3420

tttgttactc atagaactgg tgttgtttgc tgtttttatt tctctaattg ttgcagagtt     3480

ctgcctgtta caaagctaca gaactgtatt gtttttattt tccttcttga gcacatgtta     3540

acaaactaag cttcacatta gagtgatgtc ataatgtaaa atgtttgcat tgtggttagg     3600

tattgaagtt tatgtcctgt ctgtgtaaag attcatcttt tattgtaaat atttagactt     3660

taccacagaa atattggaac agtttgcttt ataagattaa aaagcatcct tcagaatgga     3720

gcttgccttg tgcttagaaa taatatgttg aactattttg caatatacta ttttaaatct     3780

aaattctgtc acttcgctgc ctttttaaaa tagtgtggta tttcaaatat tgctagagct     3840

attttcctga aatacatttg caaaataagg ctgctttgta atcaaggaat atttttattg     3900

attgaaggaa atgactgtac tgcgattcaa aagtaaactt attttattat acagattatt     3960

tcttaaaaac tctatttata ccttaacatg aaatccatga ccacaccaaa cttggttatt     4020

cataattttt cctgttaaat ataaaacact gtaagttaaa aacagtaatg ccaacattga     4080

atttattttt gaggtcaaag aaccagttgt tctctttata tttagatgag gatgattgag     4140

tccatatact atgtatgttt acatatacta tacatgcaca ttaggtgttt tcatttgtgt     4200

tttgcttatg aaatgtcatt taaagttcac ttcttgagca tcaataaaaa gggaagctgt     4260

gtggttttgg aatggtaaaa aaaa                                            4284


<210>  526
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  526

Met Thr Ile Glu Asp Leu Pro Asp Phe Pro Leu Glu Gly Asn Pro Leu 
1               5                   10                  15      


Phe Gly Arg Tyr Pro Phe Ile Phe Ser Ala Ser Asp Thr Pro Val Ile 
            20                  25                  30          


Phe Ser Ile Ser Ala Ala Pro Met Pro Ser Asp Cys Glu Phe Ser Phe 
        35                  40                  45              


Phe Asp Pro Asn Asp Ala Ser Cys Gln Glu Ile Leu Phe Asp Pro Lys 
    50                  55                  60                  


Thr Ser Val Ser Glu Leu Phe Ala Ile Leu Arg Gln Trp Val Pro Gln 
65                  70                  75                  80  


Val Gln Gln Asn Ile Asp Ile Ile Gly Asn Glu Ile Leu Lys Arg Gly 
                85                  90                  95      


Cys Asn Val Asn Asp Arg Asp Gly Leu Thr Asp Met Thr Leu Leu His 
            100                 105                 110         


Tyr Thr Cys Lys Ser Gly Ala His Gly Ile Gly Asp Val Glu Thr Ala 
        115                 120                 125             


Val Lys Phe Ala Thr Gln Leu Ile Asp Leu Gly Ala Asp Ile Ser Leu 
    130                 135                 140                 


Arg Ser Arg Trp Thr Asn Met Asn Ala Leu His Tyr Ala Ala Tyr Phe 
145                 150                 155                 160 


Asp Val Pro Glu Leu Ile Arg Val Ile Leu Lys Thr Ser Lys Pro Lys 
                165                 170                 175     


Asp Val Asp Ala Thr Cys Ser Asp Phe Asn Phe Gly Thr Ala Leu His 
            180                 185                 190         


Ile Ala Ala Tyr Asn Leu Cys Ala Gly Ala Val Lys Cys Leu Leu Glu 
        195                 200                 205             


Gln Gly Ala Asn Pro Ala Phe Arg Asn Asp Lys Gly Gln Ile Pro Ala 
    210                 215                 220                 


Asp Val Val Pro Asp Pro Val Asp Met Pro Leu Glu Met Ala Asp Ala 
225                 230                 235                 240 


Ala Ala Thr Ala Lys Glu Ile Lys Gln Met Leu Leu Asp Ala Val Pro 
                245                 250                 255     


Leu Ser Cys Asn Ile Ser Lys Ala Met Leu Pro Asn Tyr Asp His Val 
            260                 265                 270         


Thr Gly Lys Ala Met Leu Thr Ser Leu Gly Leu Lys Leu Gly Asp Arg 
        275                 280                 285             


Val Val Ile Ala Gly Gln Lys Val Gly Thr Leu Arg Phe Cys Gly Thr 
    290                 295                 300                 


Thr Glu Phe Ala Ser Gly Gln Trp Ala Gly Ile Glu Leu Asp Glu Pro 
305                 310                 315                 320 


Glu Gly Lys Asn Asn Gly Ser Val Gly Lys Val Gln Tyr Phe Lys Cys 
                325                 330                 335     


Ala Pro Lys Tyr Gly Ile Phe Ala Pro Leu Ser Lys Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Arg Arg Lys Asn Ile Thr His Thr Pro Ser Thr Lys Ala Ala 
        355                 360                 365             


Val Pro Leu Ile Arg Ser Gln Lys Ile Asp Val Ala His Val Thr Ser 
    370                 375                 380                 


Lys Val Asn Thr Gly Leu Met Thr Ser Lys Lys Asp Ser Ala Ser Glu 
385                 390                 395                 400 


Ser Thr Leu Ser Leu Pro Pro Gly Glu Glu Leu Lys Thr Val Thr Glu 
                405                 410                 415     


Lys Asp Val Ala Leu Leu Gly Ser Val Ser Ser Cys Ser Ser Thr Ser 
            420                 425                 430         


Ser Leu Glu His Arg Gln Ser Tyr Pro Lys Lys Gln Asn Ala Ile Ser 
        435                 440                 445             


Ser Asn Lys Lys Thr Met Ser Lys Ser Pro Ser Leu Ser Ser Arg Ala 
    450                 455                 460                 


Ser Ala Gly Leu Asn Ser Ser Ala Thr Ser Thr Ala Asn Asn Ser Arg 
465                 470                 475                 480 


Cys Glu Gly Glu Leu Arg Leu Gly Glu Arg Val Leu Val Val Gly Gln 
                485                 490                 495     


Arg Leu Gly Thr Ile Arg Phe Phe Gly Thr Thr Asn Phe Ala Pro Gly 
            500                 505                 510         


Tyr Trp Tyr Gly Ile Glu Leu Glu Lys Pro His Gly Lys Asn Asp Gly 
        515                 520                 525             


Ser Val Gly Gly Val Gln Tyr Phe Ser Cys Ser Pro Arg Tyr Gly Ile 
    530                 535                 540                 


Phe Ala Pro Pro Ser Arg Val Gln Arg Val Thr Asp Ser Leu Asp Thr 
545                 550                 555                 560 


Leu Ser Glu Ile Ser Ser Asn Lys Gln Asn His Ser Tyr Pro Gly Phe 
                565                 570                 575     


Arg Arg Ser Phe Ser Thr Thr Ser Ala Ser Ser Gln Lys Glu Ile Asn 
            580                 585                 590         


Arg Arg Asn Ala Phe Ser Lys Ser Lys Ala Ala Leu Arg Arg Ser Trp 
        595                 600                 605             


Ser Ser Thr Pro Thr Ala Gly Gly Ile Glu Gly Ser Val Lys Leu His 
    610                 615                 620                 


Glu Gly Ser Gln Val Leu Leu Thr Ser Ser Asn Glu Met Gly Thr Val 
625                 630                 635                 640 


Arg Tyr Val Gly Pro Thr Asp Phe Ala Ser Gly Ile Trp Leu Gly Leu 
                645                 650                 655     


Glu Leu Arg Ser Ala Lys Gly Lys Asn Asp Gly Ser Val Gly Asp Lys 
            660                 665                 670         


Arg Tyr Phe Thr Cys Lys Pro Asn His Gly Val Leu Val Arg Pro Ser 
        675                 680                 685             


Arg Val Thr Tyr Arg Gly Ile Asn Gly Ser Lys Leu Val Asp Glu Asn 
    690                 695                 700                 


Cys 
705 


<210>  527
<211>  3767
<212>  DNA
<213>  Homo Sapiens

<400>  527
agcggactgg gcatgctcgg cagcccggga ggctcgcggt ggcaagtcga aagcgttcgc       60

accagcgggg cagcggctgc gggcggcagg cggcgggcag gtcgggagtg agaaggaccg      120

gcctgggctg actgctctcc cctcgcgcct agggagccgg tcggagagcg cgattggggt      180

gcggagcccc gacgctgccc tgccccggat ttcattccgc ggcgggggct ccgcgagcgg      240

aattccggcg gctgccgtga ctccagtgca acgtgacgac agcatgtacg atccctgaat      300

gggcccgtgg gcatatttag tcattcattt ttgatcagga gaaagaagac agccatcatt      360

tgaaaggtaa agcttcagcg actgaaggag tgtggacttt ttgaatttca agaacagtaa      420

agttggaaca cagcagaggg tgtgtaataa aatacagatt ggaaagaaga ctgatgaaga      480

aaaataacag catgattcag gcacaccatt gagttctttg ggatgcccga aagtgtctgg      540

ttgggaaaca tgaaatagaa gacgagaacc tgcctcagca agcgtacctg agaatacttt      600

taaaggaacc tgttgataaa tgcaaaacag tggctgttgc aggtgatgga actgtactgg      660

aacaatggga gaagctggta gcttatagga agccaagatg accagaatgt ttttaaataa      720

tccaaggaag aatcctgctc aaaaatgagg tgaattaata cttgggcgct caggaaccct      780

ggacagctac atgaggtgtt taaaaactgc cctgaccatc ttgccaaaca agtctctgct      840

catgaggccc cacaggatga acgagccgag gcaggacagt gtcctgccct gtcggaacag      900

tgactgctga cctgccaaga gagagctggg gactgcctgc tgtctgccag tacaatgaag      960

gaagtggttt attggtcacc caagaaggtg gcagactggc tgctggagaa tgctatgcca     1020

gaatactgtg agcctctgga gcatttcaca ggccaggact tgatcaacct aacccaagag     1080

gatttcaaaa aacccccctt gtgccgagtc tcctctgaca atgggcagcg gctcctggac     1140

atgatagaaa ccctgaaaat ggagcaccat ttggaagcac acaagaacgg ccatgccaat     1200

gggcacctca acattggcgt agacatcccc acccccgacg gcagcttcag catcaagatt     1260

aaacccaacg ggatgccaaa tgggtatagg aaagagatga taaagatccc catgccagaa     1320

ctggagcgct ctcagtaccc catggagtgg ggcaagactt ttctggcctt tctttatgca     1380

ctttcctgtt tcgttctcac cacagtgatg atctcggtcg tccacgaacg agtacctcct     1440

aaggaggtgc agcctccact accggacaca ttttttgacc attttaaccg ggtgcagtgg     1500

gccttttcta tttgtgaaat taatggcatg atccttgtag gactctggtt aattcagtgg     1560

ctgctcttaa aatacaagtc tattattagc agaagatttt tctgcatagt tggcacgctg     1620

tacctgtatc ggtgtattac aatgtatgta actacactcc cagtacctgg tatgcatttc     1680

aactgttctc cgaagctttt cggagactgg gaagcccaac tgcgaagaat aatgaagctc     1740

attgctggag gtggcttgtc tatcactggc tctcacaaca tgtgtgggga ctatctgtac     1800

agcggccaca cggtcatgct aacacttacc tacttattta tcaaagagta ttcccctcgg     1860

cgactctggt ggtatcactg gatttgctgg cttctcagcg tagttggaat cttctgtatt     1920

ctcttagcgc atgaccacta cactgtggac gtggtggtgg catattacat caccacgaga     1980

ctcttctggt ggtatcacac tatggccaat cagcaagtgc taaaggaagc ttcccagatg     2040

aacctcctgg ccagggtgtg gtggtacagg ccatttcagt actttgaaaa gaatgtccaa     2100

ggaattgtac ctcgatctta ccattggcct ttcccctggc cagtagtcca cctcagtagg     2160

caagttaaat acagccggct ggtgaatgac acataacagc tgtacaaagt ggggaaaaga     2220

caaattgtcc gaagtgctaa gaactccatg agagaagatg ccataaaata aacacctccc     2280

taatcctatt atctttcaat ggttaccttg acttaaccta ttgagttacc tggtcagcac     2340

tgtgatcttt ttttctctcc aaaggacctg cgttggacaa caataaagaa aaatttaacc     2400

tatcatgcac tgtacacatt tcctgttcat aagtttggga tttacataac ccgcaaccac     2460

catgttcctt tgtatatgat gcagcagcat aaatgtaagc ttttatatca taagttctgg     2520

tctttccagt cacatctgga aataaagcgt attattttct tgggaaaaca tacttttcat     2580

atctcttgcc ccaaagattg ggctgtaagc cattttctag caaatgtctc tatgaaggtt     2640

tctaagtacc tgaatggggt ttgattctga aatctttcta cctgttgcac cgatattcaa     2700

ataaaaatga tagacacaga aaggtttggt aactttgggt tttgtaaaat cagcaaaggc     2760

agtgtttcaa aaagtgcaaa aaaaaagatt ctgttataaa gtgattttct aagtatttcc     2820

taactttatt tttcaaaatg atgttatgaa caccaaattt aaagattttt aacatgtcag     2880

agagaagaga gttaaaattt aaaaatgcat cttgggagag aaatttgtct atgtttctag     2940

tgcctttctt gtcttgattg tatggtcagt aggcaatctt aaatgttttt atttaaaata     3000

aagtattcct tgaaaatata aatatatgta tacactacta aattttgcat ttatagctaa     3060

attgaatcag aagactgctt atggttttaa aattgcaatg acttaaataa tgaggttgtt     3120

aattagagtc agagcctgtt cacatattgt gatcaggtag caatgacatg taccacttaa     3180

attattttat cgtcgatttg gtagttcaat tttaactact caatgaaaac agccatgaat     3240

atcttttctt aaagagagtt ttgaaaatga tcacttacct aaaacttgaa agctatgaat     3300

tagttatcca tactctcatg acaattttgt tggtgaacaa caaaaaagag atctatttct     3360

ttaaaagata tttgtgcaga aactgcatgt aactctaagt tttactccta acatacatat     3420

gtttggggaa gtattctatt ctatacttgc caatgtggag aacaaaatag ttttttaaga     3480

atgaagaagt atatatatcc attctgtatt ttacgtgcag cagaattatc ttccgtagga     3540

tttttttgtg tattcacaag gtgatatttg tattgtaaaa caataatggt gaaggaaata     3600

aaaaggcttt taaaattttg tttgttttaa atctttgtaa agttattatt ccagagagta     3660

tactggtatc ttacagctta cctagatcat aaattaatca aaatgcactt tttaataaaa     3720

actgatactt aaaataaatg gctgttattt ctaaaaaaaa aaaaaaa                   3767


<210>  528
<211>  413
<212>  PRT
<213>  Homo Sapiens

<400>  528

Met Lys Glu Val Val Tyr Trp Ser Pro Lys Lys Val Ala Asp Trp Leu 
1               5                   10                  15      


Leu Glu Asn Ala Met Pro Glu Tyr Cys Glu Pro Leu Glu His Phe Thr 
            20                  25                  30          


Gly Gln Asp Leu Ile Asn Leu Thr Gln Glu Asp Phe Lys Lys Pro Pro 
        35                  40                  45              


Leu Cys Arg Val Ser Ser Asp Asn Gly Gln Arg Leu Leu Asp Met Ile 
    50                  55                  60                  


Glu Thr Leu Lys Met Glu His His Leu Glu Ala His Lys Asn Gly His 
65                  70                  75                  80  


Ala Asn Gly His Leu Asn Ile Gly Val Asp Ile Pro Thr Pro Asp Gly 
                85                  90                  95      


Ser Phe Ser Ile Lys Ile Lys Pro Asn Gly Met Pro Asn Gly Tyr Arg 
            100                 105                 110         


Lys Glu Met Ile Lys Ile Pro Met Pro Glu Leu Glu Arg Ser Gln Tyr 
        115                 120                 125             


Pro Met Glu Trp Gly Lys Thr Phe Leu Ala Phe Leu Tyr Ala Leu Ser 
    130                 135                 140                 


Cys Phe Val Leu Thr Thr Val Met Ile Ser Val Val His Glu Arg Val 
145                 150                 155                 160 


Pro Pro Lys Glu Val Gln Pro Pro Leu Pro Asp Thr Phe Phe Asp His 
                165                 170                 175     


Phe Asn Arg Val Gln Trp Ala Phe Ser Ile Cys Glu Ile Asn Gly Met 
            180                 185                 190         


Ile Leu Val Gly Leu Trp Leu Ile Gln Trp Leu Leu Leu Lys Tyr Lys 
        195                 200                 205             


Ser Ile Ile Ser Arg Arg Phe Phe Cys Ile Val Gly Thr Leu Tyr Leu 
    210                 215                 220                 


Tyr Arg Cys Ile Thr Met Tyr Val Thr Thr Leu Pro Val Pro Gly Met 
225                 230                 235                 240 


His Phe Asn Cys Ser Pro Lys Leu Phe Gly Asp Trp Glu Ala Gln Leu 
                245                 250                 255     


Arg Arg Ile Met Lys Leu Ile Ala Gly Gly Gly Leu Ser Ile Thr Gly 
            260                 265                 270         


Ser His Asn Met Cys Gly Asp Tyr Leu Tyr Ser Gly His Thr Val Met 
        275                 280                 285             


Leu Thr Leu Thr Tyr Leu Phe Ile Lys Glu Tyr Ser Pro Arg Arg Leu 
    290                 295                 300                 


Trp Trp Tyr His Trp Ile Cys Trp Leu Leu Ser Val Val Gly Ile Phe 
305                 310                 315                 320 


Cys Ile Leu Leu Ala His Asp His Tyr Thr Val Asp Val Val Val Ala 
                325                 330                 335     


Tyr Tyr Ile Thr Thr Arg Leu Phe Trp Trp Tyr His Thr Met Ala Asn 
            340                 345                 350         


Gln Gln Val Leu Lys Glu Ala Ser Gln Met Asn Leu Leu Ala Arg Val 
        355                 360                 365             


Trp Trp Tyr Arg Pro Phe Gln Tyr Phe Glu Lys Asn Val Gln Gly Ile 
    370                 375                 380                 


Val Pro Arg Ser Tyr His Trp Pro Phe Pro Trp Pro Val Val His Leu 
385                 390                 395                 400 


Ser Arg Gln Val Lys Tyr Ser Arg Leu Val Asn Asp Thr 
                405                 410             


<210>  529
<211>  8815
<212>  DNA
<213>  Homo Sapiens

<400>  529
gcccgcgccg gctgtgctgc acagggggag gagagggaac cccaggcgcg agcgggaaga       60

ggggacctgc agccacaact tctctggtcc tctgcatccc ttctgtccct ccacccgtcc      120

ccttccccac cctctggccc ccaccttctt ggaggcgaca acccccggga ggcattagaa      180

gggatttttc ccgcaggttg cgaagggaag caaacttggt ggcaacttgc ctcccggtgc      240

gggcgtctct cccccaccgt ctcaacatgc ttaggggtcc ggggcccggg ctgctgctgc      300

tggccgtcca gtgcctgggg acagcggtgc cctccacggg agcctcgaag agcaagaggc      360

aggctcagca aatggttcag ccccagtccc cggtggctgt cagtcaaagc aagcccggtt      420

gttatgacaa tggaaaacac tatcagataa atcaacagtg ggagcggacc tacctaggca      480

atgcgttggt ttgtacttgt tatggaggaa gccgaggttt taactgcgag agtaaacctg      540

aagctgaaga gacttgcttt gacaagtaca ctgggaacac ttaccgagtg ggtgacactt      600

atgagcgtcc taaagactcc atgatctggg actgtacctg catcggggct gggcgaggga      660

gaataagctg taccatcgca aaccgctgcc atgaaggggg tcagtcctac aagattggtg      720

acacctggag gagaccacat gagactggtg gttacatgtt agagtgtgtg tgtcttggta      780

atggaaaagg agaatggacc tgcaagccca tagctgagaa gtgttttgat catgctgctg      840

ggacttccta tgtggtcgga gaaacgtggg agaagcccta ccaaggctgg atgatggtag      900

attgtacttg cctgggagaa ggcagcggac gcatcacttg cacttctaga aatagatgca      960

acgatcagga cacaaggaca tcctatagaa ttggagacac ctggagcaag aaggataatc     1020

gaggaaacct gctccagtgc atctgcacag gcaacggccg aggagagtgg aagtgtgaga     1080

ggcacacctc tgtgcagacc acatcgagcg gatctggccc cttcaccgat gttcgtgcag     1140

ctgtttacca accgcagcct cacccccagc ctcctcccta tggccactgt gtcacagaca     1200

gtggtgtggt ctactctgtg gggatgcagt ggctgaagac acaaggaaat aagcaaatgc     1260

tttgcacgtg cctgggcaac ggagtcagct gccaagagac agctgtaacc cagacttacg     1320

gtggcaactc aaatggagag ccatgtgtct taccattcac ctacaatggc aggacgttct     1380

actcctgcac cacagaaggg cgacaggacg gacatctttg gtgcagcaca acttcgaatt     1440

atgagcagga ccagaaatac tctttctgca cagaccacac tgttttggtt cagactcgag     1500

gaggaaattc caatggtgcc ttgtgccact tccccttcct atacaacaac cacaattaca     1560

ctgattgcac ttctgagggc agaagagaca acatgaagtg gtgtgggacc acacagaact     1620

atgatgccga ccagaagttt gggttctgcc ccatggctgc ccacgaggaa atctgcacaa     1680

ccaatgaagg ggtcatgtac cgcattggag atcagtggga taagcagcat gacatgggtc     1740

acatgatgag gtgcacgtgt gttgggaatg gtcgtgggga atggacatgc attgcctact     1800

cgcagcttcg agatcagtgc attgttgatg acatcactta caatgtgaac gacacattcc     1860

acaagcgtca tgaagagggg cacatgctga actgtacatg cttcggtcag ggtcggggca     1920

ggtggaagtg tgatcccgtc gaccaatgcc aggattcaga gactgggacg ttttatcaaa     1980

ttggagattc atgggagaag tatgtgcatg gtgtcagata ccagtgctac tgctatggcc     2040

gtggcattgg ggagtggcat tgccaacctt tacagaccta tccaagctca agtggtcctg     2100

tcgaagtatt tatcactgag actccgagtc agcccaactc ccaccccatc cagtggaatg     2160

caccacagcc atctcacatt tccaagtaca ttctcaggtg gagacctaaa aattctgtag     2220

gccgttggaa ggaagctacc ataccaggcc acttaaactc ctacaccatc aaaggcctga     2280

agcctggtgt ggtatacgag ggccagctca tcagcatcca gcagtacggc caccaagaag     2340

tgactcgctt tgacttcacc accaccagca ccagcacacc tgtgaccagc aacaccgtga     2400

caggagagac gactcccttt tctcctcttg tggccacttc tgaatctgtg accgaaatca     2460

cagccagtag ctttgtggtc tcctgggtct cagcttccga caccgtgtcg ggattccggg     2520

tggaatatga gctgagtgag gagggagatg agccacagta cctggatctt ccaagcacag     2580

ccacttctgt gaacatccct gacctgcttc ctggccgaaa atacattgta aatgtctatc     2640

agatatctga ggatggggag cagagtttga tcctgtctac ttcacaaaca acagcgcctg     2700

atgcccctcc tgacccgact gtggaccaag ttgatgacac ctcaattgtt gttcgctgga     2760

gcagacccca ggctcccatc acagggtaca gaatagtcta ttcgccatca gtagaaggta     2820

gcagcacaga actcaacctt cctgaaactg caaactccgt caccctcagt gacttgcaac     2880

ctggtgttca gtataacatc actatctatg ctgtggaaga aaatcaagaa agtacacctg     2940

ttgtcattca acaagaaacc actggcaccc cacgctcaga tacagtgccc tctcccaggg     3000

acctgcagtt tgtggaagtg acagacgtga aggtcaccat catgtggaca ccgcctgaga     3060

gtgcagtgac cggctaccgt gtggatgtga tccccgtcaa cctgcctggc gagcacgggc     3120

agaggctgcc catcagcagg aacacctttg cagaagtcac cgggctgtcc cctggggtca     3180

cctattactt caaagtcttt gcagtgagcc atgggaggga gagcaagcct ctgactgctc     3240

aacagacaac caaactggat gctcccacta acctccagtt tgtcaatgaa actgattcta     3300

ctgtcctggt gagatggact ccacctcggg cccagataac aggataccga ctgaccgtgg     3360

gccttacccg aagaggacag cccaggcagt acaatgtggg tccctctgtc tccaagtacc     3420

cactgaggaa tctgcagcct gcatctgagt acaccgtatc cctcgtggcc ataaagggca     3480

accaagagag ccccaaagcc actggagtct ttaccacact gcagcctggg agctctattc     3540

caccttacaa caccgaggtg actgagacca ccattgtgat cacatggacg cctgctccaa     3600

gaattggttt taagctgggt gtacgaccaa gccagggagg agaggcacca cgagaagtga     3660

cttcagactc aggaagcatc gttgtgtccg gcttgactcc aggagtagaa tacgtctaca     3720

ccatccaagt cctgagagat ggacaggaaa gagatgcgcc aattgtaaac aaagtggtga     3780

caccattgtc tccaccaaca aacttgcatc tggaggcaaa ccctgacact ggagtgctca     3840

cagtctcctg ggagaggagc accaccccag acattactgg ttatagaatt accacaaccc     3900

ctacaaacgg ccagcaggga aattctttgg aagaagtggt ccatgctgat cagagctcct     3960

gcacttttga taacctgagt cccggcctgg agtacaatgt cagtgtttac actgtcaagg     4020

atgacaagga aagtgtccct atctctgata ccatcatccc agaggtgccc caactcactg     4080

acctaagctt tgttgatata accgattcaa gcatcggcct gaggtggacc ccgctaaact     4140

cttccaccat tattgggtac cgcatcacag tagttgcggc aggagaaggt atccctattt     4200

ttgaagattt tgtggactcc tcagtaggat actacacagt cacagggctg gagccgggca     4260

ttgactatga tatcagcgtt atcactctca ttaatggcgg cgagagtgcc cctactacac     4320

tgacacaaca aacggctgtt cctcctccca ctgacctgcg attcaccaac attggtccag     4380

acaccatgcg tgtcacctgg gctccacccc catccattga tttaaccaac ttcctggtgc     4440

gttactcacc tgtgaaaaat gaggaagatg ttgcagagtt gtcaatttct ccttcagaca     4500

atgcagtggt cttaacaaat ctcctgcctg gtacagaata tgtagtgagt gtctccagtg     4560

tctacgaaca acatgagagc acacctctta gaggaagaca gaaaacaggt cttgattccc     4620

caactggcat tgacttttct gatattactg ccaactcttt tactgtgcac tggattgctc     4680

ctcgagccac catcactggc tacaggatcc gccatcatcc cgagcacttc agtgggagac     4740

ctcgagaaga tcgggtgccc cactctcgga attccatcac cctcaccaac ctcactccag     4800

gcacagagta tgtggtcagc atcgttgctc ttaatggcag agaggaaagt cccttattga     4860

ttggccaaca atcaacagtt tctgatgttc cgagggacct ggaagttgtt gctgcgaccc     4920

ccaccagcct actgatcagc tgggatgctc ctgctgtcac agtgagatat tacaggatca     4980

cttacggaga gacaggagga aatagccctg tccaggagtt cactgtgcct gggagcaagt     5040

ctacagctac catcagcggc cttaaacctg gagttgatta taccatcact gtgtatgctg     5100

tcactggccg tggagacagc cccgcaagca gcaagccaat ttccattaat taccgaacag     5160

aaattgacaa accatcccag atgcaagtga ccgatgttca ggacaacagc attagtgtca     5220

agtggctgcc ttcaagttcc cctgttactg gttacagagt aaccaccact cccaaaaatg     5280

gaccaggacc aacaaaaact aaaactgcag gtccagatca aacagaaatg actattgaag     5340

gcttgcagcc cacagtggag tatgtggtta gtgtctatgc tcagaatcca agcggagaga     5400

gtcagcctct ggttcagact gcagtaacca acattgatcg ccctaaagga ctggcattca     5460

ctgatgtgga tgtcgattcc atcaaaattg cttgggaaag cccacagggg caagtttcca     5520

ggtacagggt gacctactcg agccctgagg atggaatcca tgagctattc cctgcacctg     5580

atggtgaaga agacactgca gagctgcaag gcctcagacc gggttctgag tacacagtca     5640

gtgtggttgc cttgcacgat gatatggaga gccagcccct gattggaacc cagtccacag     5700

ctattcctgc accaactgac ctgaagttca ctcaggtcac acccacaagc ctgagcgccc     5760

agtggacacc acccaatgtt cagctcactg gatatcgagt gcgggtgacc cccaaggaga     5820

agaccggacc aatgaaagaa atcaaccttg ctcctgacag ctcatccgtg gttgtatcag     5880

gacttatggt ggccaccaaa tatgaagtga gtgtctatgc tcttaaggac actttgacaa     5940

gcagaccagc tcagggagtt gtcaccactc tggagaatgt cagcccacca agaagggctc     6000

gtgtgacaga tgctactgag accaccatca ccattagctg gagaaccaag actgagacga     6060

tcactggctt ccaagttgat gccgttccag ccaatggcca gactccaatc cagagaacca     6120

tcaagccaga tgtcagaagc tacaccatca caggtttaca accaggcact gactacaaga     6180

tctacctgta caccttgaat gacaatgctc ggagctcccc tgtggtcatc gacgcctcca     6240

ctgccattga tgcaccatcc aacctgcgtt tcctggccac cacacccaat tccttgctgg     6300

tatcatggca gccgccacgt gccaggatta ccggctacat catcaagtat gagaagcctg     6360

ggtctcctcc cagagaagtg gtccctcggc cccgccctgg tgtcacagag gctactatta     6420

ctggcctgga accgggaacc gaatatacaa tttatgtcat tgccctgaag aataatcaga     6480

agagcgagcc cctgattgga aggaaaaaga cagacgagct tccccaactg gtaacccttc     6540

cacaccccaa tcttcatgga ccagagatct tggatgttcc ttccacagtt caaaagaccc     6600

ctttcgtcac ccaccctggg tatgacactg gaaatggtat tcagcttcct ggcacttctg     6660

gtcagcaacc cagtgttggg caacaaatga tctttgagga acatggtttt aggcggacca     6720

caccgcccac aacggccacc cccataaggc ataggccaag accatacccg ccgaatgtag     6780

gtgaggaaat ccaaattggt cacatcccca gggaagatgt agactatcac ctgtacccac     6840

acggtccggg actcaatcca aatgcctcta caggacaaga agctctctct cagacaacca     6900

tctcatgggc cccattccag gacacttctg agtacatcat ttcatgtcat cctgttggca     6960

ctgatgaaga acccttacag ttcagggttc ctggaacttc taccagtgcc actctgacag     7020

gcctcaccag aggtgccacc tacaacatca tagtggaggc actgaaagac cagcagaggc     7080

ataaggttcg ggaagaggtt gttaccgtgg gcaactctgt caacgaaggc ttgaaccaac     7140

ctacggatga ctcgtgcttt gacccctaca cagtttccca ttatgccgtt ggagatgagt     7200

gggaacgaat gtctgaatca ggctttaaac tgttgtgcca gtgcttaggc tttggaagtg     7260

gtcatttcag atgtgattca tctagatggt gccatgacaa tggtgtgaac tacaagattg     7320

gagagaagtg ggaccgtcag ggagaaaatg gccagatgat gagctgcaca tgtcttggga     7380

acggaaaagg agaattcaag tgtgaccctc atgaggcaac gtgttatgat gatgggaaga     7440

cataccacgt aggagaacag tggcagaagg aatatctcgg tgccatttgc tcctgcacat     7500

gctttggagg ccagcggggc tggcgctgtg acaactgccg cagacctggg ggtgaaccca     7560

gtcccgaagg cactactggc cagtcctaca accagtattc tcagagatac catcagagaa     7620

caaacactaa tgttaattgc ccaattgagt gcttcatgcc tttagatgta caggctgaca     7680

gagaagattc ccgagagtaa atcatctttc caatccagag gaacaagcat gtctctctgc     7740

caagatccat ctaaactgga gtgatgttag cagacccagc ttagagttct tctttctttc     7800

ttaagccctt tgctctggag gaagttctcc agcttcagct caactcacag cttctccaag     7860

catcaccctg ggagtttcct gagggttttc tcataaatga gggctgcaca ttgcctgttc     7920

tgcttcgaag tattcaatac cgctcagtat tttaaatgaa gtgattctaa gatttggttt     7980

gggatcaata ggaaagcata tgcagccaac caagatgcaa atgttttgaa atgatatgac     8040

caaaatttta agtaggaaag tcacccaaac acttctgctt tcacttaagt gtctggcccg     8100

caatactgta ggaacaagca tgatcttgtt actgtgatat tttaaatatc cacagtactc     8160

actttttcca aatgatccta gtaattgcct agaaatatct ttctcttacc tgttatttat     8220

caatttttcc cagtattttt atacggaaaa aattgtattg aaaacactta gtatgcagtt     8280

gataagagga atttggtata attatggtgg gtgattattt tttatactgt atgtgccaaa     8340

gctttactac tgtggaaaga caactgtttt aataaaagat ttacattcca caacttgaag     8400

ttcatctatt tgatataaga caccttcggg ggaaataatt cctgtgaata ttctttttca     8460

attcagcaaa catttgaaaa tctatgatgt gcaagtctaa ttgttgattt cagtacaaga     8520

ttttctaaat cagttgctac aaaaactgat tggtttttgt cacttcatct cttcactaat     8580

ggagatagct ttacactttc tgctttaata gatttaagtg gaccccaata tttattaaaa     8640

ttgctagttt accgttcaga agtataatag aaataatctt tagttgctct tttctaacca     8700

ttgtaattct tcccttcttc cctccacctt tccttcattg aataaacctc tgttcaaaga     8760

gattgcctgc aagggaaata aaaatgacta agatattaaa aaaaaaaaaa aaaaa          8815


<210>  530
<211>  2477
<212>  PRT
<213>  Homo Sapiens

<400>  530

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Ile Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


<210>  531
<211>  1255
<212>  DNA
<213>  Homo Sapiens

<400>  531
gggacagagg cctcagagag ccacccaatg agtccacagc agccatggac agtccgtgag       60

ggggagggtg tgcctgcagg gggcgtggcc ccatgccgcc cgccacctgc atgcgcactg      120

ggccgaccaa tcagcgagga gcgcgggcag ccggggcggc tgctgctctc gtgagaacag      180

aggacccagg ccctcggagg agcttcgcgg tgccagcctc tgcaggtcct ctgagggagc      240

aacatcaggg ctccctcagg ttcagaggtc gcctctagct tcccaggcca gtcagccacg      300

gagcccgtgg gcaggaaggg cagcaggatg gctgccaagg accagttgga ggttcaagtt      360

atggccgccc aggaaatgga gcttgcagga aaggatccag taagtcatga gcatgaggaa      420

agaaaacctg ttacagagac aaaggaggga gatgtaactg atgagcatgg ggaaagagga      480

tcttttgctg aaacagatga acacacgggg gttgatacca aggagctaga agatattgca      540

gctgacatta aagagcatct tgctgcaaag agaaaaagga ttgaaaagat tgcaaaagct      600

tgcagcgaaa taaagaacag aattaaaaat gttttgagaa caacacaact aaaaaggcag      660

aaacgtgatt atagaatttc tctgaagttg ccgaatgtcc ttgaagagtt catcacagat      720

gagcagaaag atgaggaagg agatggagaa aaggaagaac aaattaaaat atttcaagag      780

caacaaaaga ggtggcaaca agatgggaaa ggaactgaaa gagattgagc caccacacga      840

gcaattcaca aagctgcagc aagagttggc acttattcag atgtatcttc aacctctgtt      900

attctggtga ctgacaaaag aacttgaacc tatgttatat gatacatgca taacttgagc      960

tacactaaac cacatgacag tgtttagtta attcttgtat aaattagtat atctcttcta     1020

ttattagtct gtttgttaaa tgccagacca cgtttctatg atctgttgaa tgaaccctag     1080

acagttctgt gagaaagcag caattgcaca gttacataca cagtcaatta aattttaaca     1140

ttaaagataa tttagtttta ggtttggcct ctgtggatct gtatcagttc caaaatgtgg     1200

aaagcacggg catggaaaag tacatttttc tctaataaaa gaagacaaac cctta          1255


<210>  532
<211>  166
<212>  PRT
<213>  Homo Sapiens

<400>  532

Met Ala Ala Lys Asp Gln Leu Glu Val Gln Val Met Ala Ala Gln Glu 
1               5                   10                  15      


Met Glu Leu Ala Gly Lys Asp Pro Val Ser His Glu His Glu Glu Arg 
            20                  25                  30          


Lys Pro Val Thr Glu Thr Lys Glu Gly Asp Val Thr Asp Glu His Gly 
        35                  40                  45              


Glu Arg Gly Ser Phe Ala Glu Thr Asp Glu His Thr Gly Val Asp Thr 
    50                  55                  60                  


Lys Glu Leu Glu Asp Ile Ala Ala Asp Ile Lys Glu His Leu Ala Ala 
65                  70                  75                  80  


Lys Arg Lys Arg Ile Glu Lys Ile Ala Lys Ala Cys Ser Glu Ile Lys 
                85                  90                  95      


Asn Arg Ile Lys Asn Val Leu Arg Thr Thr Gln Leu Lys Arg Gln Lys 
            100                 105                 110         


Arg Asp Tyr Arg Ile Ser Leu Lys Leu Pro Asn Val Leu Glu Glu Phe 
        115                 120                 125             


Ile Thr Asp Glu Gln Lys Asp Glu Glu Gly Asp Gly Glu Lys Glu Glu 
    130                 135                 140                 


Gln Ile Lys Ile Phe Gln Glu Gln Gln Lys Arg Trp Gln Gln Asp Gly 
145                 150                 155                 160 


Lys Gly Thr Glu Arg Asp 
                165     


<210>  533
<211>  6051
<212>  DNA
<213>  Homo Sapiens

<400>  533
tggtgaggtt gcctgtaact gacttcaaaa ggccattcca ccattccgtc aagccagctg       60

ctttagaacg gttgggaaca ccgtgagacc agtgaattcc acgagcacga acccactgct      120

gcgcttcatt tgctgtgaag tgagtccctt gatcagagca atgctgtgtg gaccatcgtg      180

aaggtggaca aggcatttta aaggggatgt ttgggctgaa ggtgaagaag aagagaaata      240

aggcagagaa ggggttaatc ctagccaaca aggctgcgaa agatagtcaa ggtgacactg      300

aagcactgca ggaggagcct tctcaccagg aaggaccgag aggagatttg gtccatgatg      360

atgcttctat ctttcctgtc ccctcagctt ctccaaagag aagatcaaaa ctgttgacta      420

agatccatga tggggaggtc agatcccaaa attatcaaat tgccataacc atcaccgagg      480

ctcgccagct ggtgggtgag aacattgacc cagttgtgac cattgagatt ggggatgaga      540

agaagcaaag cacagtgaag gaaggaacca acagcccatt ttataatgaa tactttgtct      600

tcgacttcat tgggccccaa gtgcatcttt ttgacaagat catcaaaatc tccgtctttc      660

accacaagct gataggaagt gtactgattg gctctttcaa agtagacctg gggaccgtgt      720

acaaccaacc tggtcatcag ttctgcaaca agtgggccct gctcacagac cctggtgaca      780

tcaggactgg caccaagggg tacctgaaat gtgacatcag tgtcatggga aaaggtgatg      840

tcttgaagac cagccctaaa acttctgaca ccgaggagcc aatagaaaag aaccttttga      900

tccccaatgg gtttccactg gagagaccgt gggccagatt ctatgtgaga ctctacaaag      960

cagaagggtt gcccaaaatg aattcaagca tcatggcgaa cgtcaccaag gcatttgtgg     1020

gtgacagtaa ggacctggtg gatccctttg tggaggtctc ctttgctggg cagatggggc     1080

gaaccacagt gcagaagaac tgtgctgatc ctgtgtggca tgaacaggtg atcttcaagg     1140

aaatgttccc tcccttgtgt cggagggtga aaatccaggt gtgggatgaa ggcagcatga     1200

atgacgtagc cctggcaacc catttcattg acctgaagaa aatctccaac gaacaggatg     1260

gagacaaagg ctttctgccc acctttgggc ctgcctggat taacctgtat ggctcgccca     1320

ggaaccacag tctgatggat gactaccagg aaatgaacga aggctttggg gaaggtgtgt     1380

cattcagggg cagaatcttg gtagaaattg ctgtggaaat cctctcagga cgggcacagg     1440

aatctaaatt ttccaaggcc ctgaaggagc tcaagttgcc ttccaaggac aaagactcca     1500

aatcttccaa aggtaaagac aaggctgaca aaactgaaga tggaaaatcc caacaggctt     1560

caaacaaaac taactcaacc gaggtggagg tggaatcgtt cgatgtcccc ccggagattg     1620

taccagaaaa aaatgaggaa tttttactct ttggagcatt ttttgaagct accatgattg     1680

accggaagat tggagataaa cccatcagct ttgaagtttc tattggtaat tttggaaacc     1740

tgattgatgg aggatcccat catgggagta agaagtcagc tgaatcagct gaagaagacc     1800

tccttccact gcttcacgaa gggcaagggg atgtggccca tgatgttccc attcctatgg     1860

cctccaccac tcacccggag aagccactgg tgacagaagg gaacaggaat tacaactatt     1920

tgccatttga ggctaagaag ccctgtgtct atttcatcag ctcttgggga gaccagacct     1980

tcaggctgca ctggtccaac atgctggaga aaatggcaga cttcctggaa gaaagtatag     2040

aagaagtgag agaattgatc aagatttcac aggaggcacc tgaagagaaa atgaaaacag     2100

tgctcagtga cttcatcagt cggagcagtg cctttatctc tgaagcagaa aaaaagccca     2160

agatgttgaa ccaaaccact ttagataaga agcgacttac gctctgctgg caggagctgg     2220

aagcaatgtg caaggaggcc aaggggatca ttcagcagca gaagaaaaag ttatctgttg     2280

atgaaatgat tcacgaagcc caaaactttg tggaaaaaat ccgctttctt gttgatgagc     2340

cccagcacac tatccctgac gttttcatct ggatgctcag caacaacagg agagtggcct     2400

atgcccgcat cgcctccaaa gacctcctct attcccctgt cgcggggcag atgggcaaac     2460

actgcggcaa gatcaaaact cacttcctca aacctcctgg gaaacgaccg gctggttggt     2520

ctgtgcaagc aaaagtcgac gtgtacctgt ggctgggctc catcaagcat gccagtgcca     2580

ttttggacaa cttgccagta ggctatgaag cagaaatgtc ctccaaaggg gctggcacca     2640

atcacccccc atctaacctg ctctaccaag aacagcatgt ttttcagctg agggctcaca     2700

tgtaccaagc ccggggcctc atcgcagctg acagcaatgg actttcagac ccttttgcca     2760

aagtcacgtt cctttctcac tgccagacaa caaagataat ctcccagacc ctctctccga     2820

cctggaacca gatgctgctg ttcaatgatt tggtgctgca tggagatgtg aaggagctgg     2880

cagagtcccc gcccttagtg gtggtggagc tgtatgacag cgacgctgtg gggaagccag     2940

aatatttggg tgccacagtg gctgctcctg ttgtgaagct ggctgaccag gactatgagc     3000

cccccaggtt atgctatcac cccatctttt gtgggaatct ctctggaggg gatctccttg     3060

ctgtatttga actgctgcag gttcctcctt ctgggctgca aggcctccca cccgttgagc     3120

caccagacat cacccagatc tacccggttc ctgccaacat tcggccggtg ctgagcaaat     3180

accgagtgga ggttctcttc tggggagttc gggaaatgaa gaaggtgcag ctcctctctg     3240

tggatcggcc tcaggctctc attgagtgcg gaggacaagg tgtgaagtcc tgcgtgatcc     3300

agagctacaa gaacaacccg aacttcagca tccaggcaga cgctttcgaa gtggaactgc     3360

ctgagaacga gcttctgcac ccgccactga gcatctgcgt ggtggactgg agagcttttg     3420

ggaggagtac ccttgtgggc acctacacca tcaactactt gaagcagttt ttgtgtaaac     3480

tcagagagcc ccttgccccc atcacacagg tggatggaac ccagcctggg cacgatattt     3540

cagattcgct aacagccact gagtcctctg gagcccacag ctcctcccag gatcccccag     3600

cagatcacat ttatgtggat gttgagccac ctcccacagt ggtgcccgac tctgcccagg     3660

cccagccggc catcctggtt gacgtccctg actcatcccc gatgctggag cctgaacaca     3720

cacctgtagc ccaggagcca ccaaaagatg gaaaacctaa ggatcccagg aagccttccc     3780

ggaggtccac taagaggaga aagaggacca tagcagatga atctgctgaa aacgtgattg     3840

actggtggtc taagtattat gcctccctga agaaagccca gaaggcaaag gagagaaatc     3900

ccaagggaaa aaaaggcaat acagaggcaa agccagatga ggtagtggta gatatagaag     3960

atgggccaaa gaagaagaaa gacaaaatgc tcaagaagaa acccaaagat gatggaatcc     4020

ccaacctggc catcttgcag atatatgacg gtgatctcga gagtgaattc aacaattttg     4080

aagactgggt gaaaactttt gagctcttca gaggcaagtc tacggaagat gaccatggtc     4140

ttgatggaga ccgagtcata ggaaaattta agggctcctt ctgcatctac aaaagccccc     4200

aggattctag ctctgaggac agcgggcagc tgagaatcca gcaagggatt ccgcccaatc     4260

accctgtcac agtgctgatc agagtataca ttgtcgcggc atttaatctt agtccagctg     4320

atccagatgg caaatcagat ccctacattg tgatcaagct tggcaagaca gaaatcaaag     4380

accgggataa atacatccct aaacaactga acccagtatt tggaaggtca tttgagatcc     4440

aagccacatt cccaaaagag tccctgctct ccatcctgat ctatgaccat gacatgattg     4500

gcacagatga ccttattggt gagaccaaga tcgacctgga gaaccgcttc tacagcaaac     4560

accgagccat ctgtggcttg cagagccagt atgagataga aggatacaat gcctggagag     4620

acacgtccaa acccaccgaa atcctcacta agctctgcaa agacaacaag ctggatggac     4680

cctactttca ccctgggaaa atacagatag gaaaccaagt cttttctgga aaaactatct     4740

tcactgaaga ggacactgat gagacagtgg agtcttatga acacctggcc ctcaaggttt     4800

tacactcttg ggaggatatc ccggaagtcg ggtgtaggct ggttcctgaa cacatagaaa     4860

ctcggccact gtaccacaag gataagccag gaatggagca gggccgcctg cagatgtggg     4920

tggacatgtt tcccaaggat atgcctcaac ctggacctcc tgttgacatc tctccaaggc     4980

gacccaaagg atacgaattg agagtgacca tctggaacac tgaagatgtc attttagagg     5040

atgagaatat cttcacaggc caaaaatcaa gtgatattta tgtgaaaggg tggttaaagg     5100

gcttggagga tgacaagcag gagacagatg tgcattacaa ctccctgact ggagagggca     5160

acttcaactg gcgcttcctg tttccctttc agtatctccc agctgagaag caaatggtca     5220

ttaccaagag ggagaacatc ttctctttag agaagatgga gtgtaagact cctgctgtgt     5280

tggtgctgca ggtttgggat tttgaaaggc tgtcctcaga tgacttcctg ggcaccctgg     5340

aaatgaacct caacagtttc cctcgagcag ctaagtctgc caaagcctgt gatcttgcca     5400

agtttgaaaa tgcaagtgag gagaccaaga tctctatatt ccagcaaaaa cgtgtgcgtg     5460

gctggtggcc tttttctaaa agcaaagaac tcacaggcaa ggttgaagct gagttccacc     5520

tagttacagc agaagaagct gagaaaaatc ctgttggaaa agcccgaaag gagccagagc     5580

ccctggccaa gcccaaccgc ccagacacct ccttttcgtg gttcatgagc ccctttaagt     5640

gcctgtacta cctcatctgg aagaattaca aaaagtacat catcattgct ttcattctca     5700

tcatcctcat catcttcctc gtccttttca tctacacctt gccaggagcc atcagccgaa     5760

ggatcgttgt gggctcatag aggatcatgg aggacccaga tcctcgccat atactaatcc     5820

tctcttcctt atctgggagc atctaagaac atgtcccatg catggcactg tgctgagtgc     5880

taaggggaca gatcaaccct tcttggaaga gatggaaaag aaacatttcc tccctgctcc     5940

aacccctgcc tccaagtttc aaacttgtaa ggcatgtttt atcccttggg cagcatgaaa     6000

taaggcactt tcacctcatg gtaatcaaca atgacctcaa attgacttag a              6051


<210>  534
<211>  1857
<212>  PRT
<213>  Homo Sapiens

<400>  534

Met Phe Gly Leu Lys Val Lys Lys Lys Arg Asn Lys Ala Glu Lys Gly 
1               5                   10                  15      


Leu Ile Leu Ala Asn Lys Ala Ala Lys Asp Ser Gln Gly Asp Thr Glu 
            20                  25                  30          


Ala Leu Gln Glu Glu Pro Ser His Gln Glu Gly Pro Arg Gly Asp Leu 
        35                  40                  45              


Val His Asp Asp Ala Ser Ile Phe Pro Val Pro Ser Ala Ser Pro Lys 
    50                  55                  60                  


Arg Arg Ser Lys Leu Leu Thr Lys Ile His Asp Gly Glu Val Arg Ser 
65                  70                  75                  80  


Gln Asn Tyr Gln Ile Ala Ile Thr Ile Thr Glu Ala Arg Gln Leu Val 
                85                  90                  95      


Gly Glu Asn Ile Asp Pro Val Val Thr Ile Glu Ile Gly Asp Glu Lys 
            100                 105                 110         


Lys Gln Ser Thr Val Lys Glu Gly Thr Asn Ser Pro Phe Tyr Asn Glu 
        115                 120                 125             


Tyr Phe Val Phe Asp Phe Ile Gly Pro Gln Val His Leu Phe Asp Lys 
    130                 135                 140                 


Ile Ile Lys Ile Ser Val Phe His His Lys Leu Ile Gly Ser Val Leu 
145                 150                 155                 160 


Ile Gly Ser Phe Lys Val Asp Leu Gly Thr Val Tyr Asn Gln Pro Gly 
                165                 170                 175     


His Gln Phe Cys Asn Lys Trp Ala Leu Leu Thr Asp Pro Gly Asp Ile 
            180                 185                 190         


Arg Thr Gly Thr Lys Gly Tyr Leu Lys Cys Asp Ile Ser Val Met Gly 
        195                 200                 205             


Lys Gly Asp Val Leu Lys Thr Ser Pro Lys Thr Ser Asp Thr Glu Glu 
    210                 215                 220                 


Pro Ile Glu Lys Asn Leu Leu Ile Pro Asn Gly Phe Pro Leu Glu Arg 
225                 230                 235                 240 


Pro Trp Ala Arg Phe Tyr Val Arg Leu Tyr Lys Ala Glu Gly Leu Pro 
                245                 250                 255     


Lys Met Asn Ser Ser Ile Met Ala Asn Val Thr Lys Ala Phe Val Gly 
            260                 265                 270         


Asp Ser Lys Asp Leu Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly 
        275                 280                 285             


Gln Met Gly Arg Thr Thr Val Gln Lys Asn Cys Ala Asp Pro Val Trp 
    290                 295                 300                 


His Glu Gln Val Ile Phe Lys Glu Met Phe Pro Pro Leu Cys Arg Arg 
305                 310                 315                 320 


Val Lys Ile Gln Val Trp Asp Glu Gly Ser Met Asn Asp Val Ala Leu 
                325                 330                 335     


Ala Thr His Phe Ile Asp Leu Lys Lys Ile Ser Asn Glu Gln Asp Gly 
            340                 345                 350         


Asp Lys Gly Phe Leu Pro Thr Phe Gly Pro Ala Trp Ile Asn Leu Tyr 
        355                 360                 365             


Gly Ser Pro Arg Asn His Ser Leu Met Asp Asp Tyr Gln Glu Met Asn 
    370                 375                 380                 


Glu Gly Phe Gly Glu Gly Val Ser Phe Arg Gly Arg Ile Leu Val Glu 
385                 390                 395                 400 


Ile Ala Val Glu Ile Leu Ser Gly Arg Ala Gln Glu Ser Lys Phe Ser 
                405                 410                 415     


Lys Ala Leu Lys Glu Leu Lys Leu Pro Ser Lys Asp Lys Asp Ser Lys 
            420                 425                 430         


Ser Ser Lys Gly Lys Asp Lys Ala Asp Lys Thr Glu Asp Gly Lys Ser 
        435                 440                 445             


Gln Gln Ala Ser Asn Lys Thr Asn Ser Thr Glu Val Glu Val Glu Ser 
    450                 455                 460                 


Phe Asp Val Pro Pro Glu Ile Val Pro Glu Lys Asn Glu Glu Phe Leu 
465                 470                 475                 480 


Leu Phe Gly Ala Phe Phe Glu Ala Thr Met Ile Asp Arg Lys Ile Gly 
                485                 490                 495     


Asp Lys Pro Ile Ser Phe Glu Val Ser Ile Gly Asn Phe Gly Asn Leu 
            500                 505                 510         


Ile Asp Gly Gly Ser His His Gly Ser Lys Lys Ser Ala Glu Ser Ala 
        515                 520                 525             


Glu Glu Asp Leu Leu Pro Leu Leu His Glu Gly Gln Gly Asp Val Ala 
    530                 535                 540                 


His Asp Val Pro Ile Pro Met Ala Ser Thr Thr His Pro Glu Lys Pro 
545                 550                 555                 560 


Leu Val Thr Glu Gly Asn Arg Asn Tyr Asn Tyr Leu Pro Phe Glu Ala 
                565                 570                 575     


Lys Lys Pro Cys Val Tyr Phe Ile Ser Ser Trp Gly Asp Gln Thr Phe 
            580                 585                 590         


Arg Leu His Trp Ser Asn Met Leu Glu Lys Met Ala Asp Phe Leu Glu 
        595                 600                 605             


Glu Ser Ile Glu Glu Val Arg Glu Leu Ile Lys Ile Ser Gln Glu Ala 
    610                 615                 620                 


Pro Glu Glu Lys Met Lys Thr Val Leu Ser Asp Phe Ile Ser Arg Ser 
625                 630                 635                 640 


Ser Ala Phe Ile Ser Glu Ala Glu Lys Lys Pro Lys Met Leu Asn Gln 
                645                 650                 655     


Thr Thr Leu Asp Lys Lys Arg Leu Thr Leu Cys Trp Gln Glu Leu Glu 
            660                 665                 670         


Ala Met Cys Lys Glu Ala Lys Gly Ile Ile Gln Gln Gln Lys Lys Lys 
        675                 680                 685             


Leu Ser Val Asp Glu Met Ile His Glu Ala Gln Asn Phe Val Glu Lys 
    690                 695                 700                 


Ile Arg Phe Leu Val Asp Glu Pro Gln His Thr Ile Pro Asp Val Phe 
705                 710                 715                 720 


Ile Trp Met Leu Ser Asn Asn Arg Arg Val Ala Tyr Ala Arg Ile Ala 
                725                 730                 735     


Ser Lys Asp Leu Leu Tyr Ser Pro Val Ala Gly Gln Met Gly Lys His 
            740                 745                 750         


Cys Gly Lys Ile Lys Thr His Phe Leu Lys Pro Pro Gly Lys Arg Pro 
        755                 760                 765             


Ala Gly Trp Ser Val Gln Ala Lys Val Asp Val Tyr Leu Trp Leu Gly 
    770                 775                 780                 


Ser Ile Lys His Ala Ser Ala Ile Leu Asp Asn Leu Pro Val Gly Tyr 
785                 790                 795                 800 


Glu Ala Glu Met Ser Ser Lys Gly Ala Gly Thr Asn His Pro Pro Ser 
                805                 810                 815     


Asn Leu Leu Tyr Gln Glu Gln His Val Phe Gln Leu Arg Ala His Met 
            820                 825                 830         


Tyr Gln Ala Arg Gly Leu Ile Ala Ala Asp Ser Asn Gly Leu Ser Asp 
        835                 840                 845             


Pro Phe Ala Lys Val Thr Phe Leu Ser His Cys Gln Thr Thr Lys Ile 
    850                 855                 860                 


Ile Ser Gln Thr Leu Ser Pro Thr Trp Asn Gln Met Leu Leu Phe Asn 
865                 870                 875                 880 


Asp Leu Val Leu His Gly Asp Val Lys Glu Leu Ala Glu Ser Pro Pro 
                885                 890                 895     


Leu Val Val Val Glu Leu Tyr Asp Ser Asp Ala Val Gly Lys Pro Glu 
            900                 905                 910         


Tyr Leu Gly Ala Thr Val Ala Ala Pro Val Val Lys Leu Ala Asp Gln 
        915                 920                 925             


Asp Tyr Glu Pro Pro Arg Leu Cys Tyr His Pro Ile Phe Cys Gly Asn 
    930                 935                 940                 


Leu Ser Gly Gly Asp Leu Leu Ala Val Phe Glu Leu Leu Gln Val Pro 
945                 950                 955                 960 


Pro Ser Gly Leu Gln Gly Leu Pro Pro Val Glu Pro Pro Asp Ile Thr 
                965                 970                 975     


Gln Ile Tyr Pro Val Pro Ala Asn Ile Arg Pro Val Leu Ser Lys Tyr 
            980                 985                 990         


Arg Val Glu Val Leu Phe Trp Gly  Val Arg Glu Met Lys  Lys Val Gln 
        995                 1000                 1005             


Leu Leu  Ser Val Asp Arg Pro  Gln Ala Leu Ile Glu  Cys Gly Gly 
    1010                 1015                 1020             


Gln Gly  Val Lys Ser Cys Val  Ile Gln Ser Tyr Lys  Asn Asn Pro 
    1025                 1030                 1035             


Asn Phe  Ser Ile Gln Ala Asp  Ala Phe Glu Val Glu  Leu Pro Glu 
    1040                 1045                 1050             


Asn Glu  Leu Leu His Pro Pro  Leu Ser Ile Cys Val  Val Asp Trp 
    1055                 1060                 1065             


Arg Ala  Phe Gly Arg Ser Thr  Leu Val Gly Thr Tyr  Thr Ile Asn 
    1070                 1075                 1080             


Tyr Leu  Lys Gln Phe Leu Cys  Lys Leu Arg Glu Pro  Leu Ala Pro 
    1085                 1090                 1095             


Ile Thr  Gln Val Asp Gly Thr  Gln Pro Gly His Asp  Ile Ser Asp 
    1100                 1105                 1110             


Ser Leu  Thr Ala Thr Glu Ser  Ser Gly Ala His Ser  Ser Ser Gln 
    1115                 1120                 1125             


Asp Pro  Pro Ala Asp His Ile  Tyr Val Asp Val Glu  Pro Pro Pro 
    1130                 1135                 1140             


Thr Val  Val Pro Asp Ser Ala  Gln Ala Gln Pro Ala  Ile Leu Val 
    1145                 1150                 1155             


Asp Val  Pro Asp Ser Ser Pro  Met Leu Glu Pro Glu  His Thr Pro 
    1160                 1165                 1170             


Val Ala  Gln Glu Pro Pro Lys  Asp Gly Lys Pro Lys  Asp Pro Arg 
    1175                 1180                 1185             


Lys Pro  Ser Arg Arg Ser Thr  Lys Arg Arg Lys Arg  Thr Ile Ala 
    1190                 1195                 1200             


Asp Glu  Ser Ala Glu Asn Val  Ile Asp Trp Trp Ser  Lys Tyr Tyr 
    1205                 1210                 1215             


Ala Ser  Leu Lys Lys Ala Gln  Lys Ala Lys Glu Arg  Asn Pro Lys 
    1220                 1225                 1230             


Gly Lys  Lys Gly Asn Thr Glu  Ala Lys Pro Asp Glu  Val Val Val 
    1235                 1240                 1245             


Asp Ile  Glu Asp Gly Pro Lys  Lys Lys Lys Asp Lys  Met Leu Lys 
    1250                 1255                 1260             


Lys Lys  Pro Lys Asp Asp Gly  Ile Pro Asn Leu Ala  Ile Leu Gln 
    1265                 1270                 1275             


Ile Tyr  Asp Gly Asp Leu Glu  Ser Glu Phe Asn Asn  Phe Glu Asp 
    1280                 1285                 1290             


Trp Val  Lys Thr Phe Glu Leu  Phe Arg Gly Lys Ser  Thr Glu Asp 
    1295                 1300                 1305             


Asp His  Gly Leu Asp Gly Asp  Arg Val Ile Gly Lys  Phe Lys Gly 
    1310                 1315                 1320             


Ser Phe  Cys Ile Tyr Lys Ser  Pro Gln Asp Ser Ser  Ser Glu Asp 
    1325                 1330                 1335             


Ser Gly  Gln Leu Arg Ile Gln  Gln Gly Ile Pro Pro  Asn His Pro 
    1340                 1345                 1350             


Val Thr  Val Leu Ile Arg Val  Tyr Ile Val Ala Ala  Phe Asn Leu 
    1355                 1360                 1365             


Ser Pro  Ala Asp Pro Asp Gly  Lys Ser Asp Pro Tyr  Ile Val Ile 
    1370                 1375                 1380             


Lys Leu  Gly Lys Thr Glu Ile  Lys Asp Arg Asp Lys  Tyr Ile Pro 
    1385                 1390                 1395             


Lys Gln  Leu Asn Pro Val Phe  Gly Arg Ser Phe Glu  Ile Gln Ala 
    1400                 1405                 1410             


Thr Phe  Pro Lys Glu Ser Leu  Leu Ser Ile Leu Ile  Tyr Asp His 
    1415                 1420                 1425             


Asp Met  Ile Gly Thr Asp Asp  Leu Ile Gly Glu Thr  Lys Ile Asp 
    1430                 1435                 1440             


Leu Glu  Asn Arg Phe Tyr Ser  Lys His Arg Ala Ile  Cys Gly Leu 
    1445                 1450                 1455             


Gln Ser  Gln Tyr Glu Ile Glu  Gly Tyr Asn Ala Trp  Arg Asp Thr 
    1460                 1465                 1470             


Ser Lys  Pro Thr Glu Ile Leu  Thr Lys Leu Cys Lys  Asp Asn Lys 
    1475                 1480                 1485             


Leu Asp  Gly Pro Tyr Phe His  Pro Gly Lys Ile Gln  Ile Gly Asn 
    1490                 1495                 1500             


Gln Val  Phe Ser Gly Lys Thr  Ile Phe Thr Glu Glu  Asp Thr Asp 
    1505                 1510                 1515             


Glu Thr  Val Glu Ser Tyr Glu  His Leu Ala Leu Lys  Val Leu His 
    1520                 1525                 1530             


Ser Trp  Glu Asp Ile Pro Glu  Val Gly Cys Arg Leu  Val Pro Glu 
    1535                 1540                 1545             


His Ile  Glu Thr Arg Pro Leu  Tyr His Lys Asp Lys  Pro Gly Met 
    1550                 1555                 1560             


Glu Gln  Gly Arg Leu Gln Met  Trp Val Asp Met Phe  Pro Lys Asp 
    1565                 1570                 1575             


Met Pro  Gln Pro Gly Pro Pro  Val Asp Ile Ser Pro  Arg Arg Pro 
    1580                 1585                 1590             


Lys Gly  Tyr Glu Leu Arg Val  Thr Ile Trp Asn Thr  Glu Asp Val 
    1595                 1600                 1605             


Ile Leu  Glu Asp Glu Asn Ile  Phe Thr Gly Gln Lys  Ser Ser Asp 
    1610                 1615                 1620             


Ile Tyr  Val Lys Gly Trp Leu  Lys Gly Leu Glu Asp  Asp Lys Gln 
    1625                 1630                 1635             


Glu Thr  Asp Val His Tyr Asn  Ser Leu Thr Gly Glu  Gly Asn Phe 
    1640                 1645                 1650             


Asn Trp  Arg Phe Leu Phe Pro  Phe Gln Tyr Leu Pro  Ala Glu Lys 
    1655                 1660                 1665             


Gln Met  Val Ile Thr Lys Arg  Glu Asn Ile Phe Ser  Leu Glu Lys 
    1670                 1675                 1680             


Met Glu  Cys Lys Thr Pro Ala  Val Leu Val Leu Gln  Val Trp Asp 
    1685                 1690                 1695             


Phe Glu  Arg Leu Ser Ser Asp  Asp Phe Leu Gly Thr  Leu Glu Met 
    1700                 1705                 1710             


Asn Leu  Asn Ser Phe Pro Arg  Ala Ala Lys Ser Ala  Lys Ala Cys 
    1715                 1720                 1725             


Asp Leu  Ala Lys Phe Glu Asn  Ala Ser Glu Glu Thr  Lys Ile Ser 
    1730                 1735                 1740             


Ile Phe  Gln Gln Lys Arg Val  Arg Gly Trp Trp Pro  Phe Ser Lys 
    1745                 1750                 1755             


Ser Lys  Glu Leu Thr Gly Lys  Val Glu Ala Glu Phe  His Leu Val 
    1760                 1765                 1770             


Thr Ala  Glu Glu Ala Glu Lys  Asn Pro Val Gly Lys  Ala Arg Lys 
    1775                 1780                 1785             


Glu Pro  Glu Pro Leu Ala Lys  Pro Asn Arg Pro Asp  Thr Ser Phe 
    1790                 1795                 1800             


Ser Trp  Phe Met Ser Pro Phe  Lys Cys Leu Tyr Tyr  Leu Ile Trp 
    1805                 1810                 1815             


Lys Asn  Tyr Lys Lys Tyr Ile  Ile Ile Ala Phe Ile  Leu Ile Ile 
    1820                 1825                 1830             


Leu Ile  Ile Phe Leu Val Leu  Phe Ile Tyr Thr Leu  Pro Gly Ala 
    1835                 1840                 1845             


Ile Ser  Arg Arg Ile Val Val  Gly Ser 
    1850                 1855         


<210>  535
<211>  1502
<212>  RNA
<213>  Homo Sapiens

<400>  535
ggaggggcgg gcggccccag gcgggcgggc gcagggcgca gggcgccgac cgcggagagg       60

gggccccggg cgcgaggcgg agcccggcgc gcagccaggc gggggggccc ccggcaggcg      120

cagacccccg gcccgggagc cgcagcagga ccggccagga ggcgccaaga ggggagcccc      180

acccgggcga caggcccacc gcgcccacga ggaccagcgg ccgccggcgg cgggggcgcg      240

gcgacccacc ggccccgagg gccagcgcaa caccgcccaa caccagagcg gcgcgccacg      300

accgcgcgac cgcagggcgc accagggggg gcagcgacgg caggacagca ggacggccac      360

gagacggggc agaggccgcg gccaacggga ggagacgaag gacagaaggc acgcaacacc      420

gcggcccgca acaggaagac aaggcagcgg ggaacacaac agccagccac gcccggagga      480

ccagggggag agggaggaag aaggccaagg aggccgcacc cgaggccaga caaaacacca      540

aacagcaaaa cgagaggaaa gcaagccgac ccaaacgacc accgacagga agacaagaag      600

accagagaac aaacaaacca cagagggaga agggacccag ggaacacaac ccccagacca      660

cgaccagcca caagaggcga cgggcccagc caacgaagac gcggagcaag caggagagga      720

accaggagaa aagcgggaga gcgggggccc cagccaacgc aaaaacggcc ccggaagacg      780

gagggcagca cccgacccaa accgacaagc aagacccgga agcaagaaag gaggagaaag      840

gaggagcgca gagcgagggg accgaagacc aggccaaaag gccggagccc cgaccccggc      900

cacagcgcca accccgcacc aaccacagag ggggccgcgg ggggaggaga gccaaccagc      960

aggcccggac agagagacac gggaacacgg agcaaagaaa aaaacccgac aaaagaagaa     1020

aagaagggca aagacccaac ccggaaaaaa aacagccgag ggccaacaag aaaccgaaac     1080

ggaaagaaga aaaggaacac acagaggagg cgagaagcca aggccagggg caaacagcca     1140

gagaagacgc gaagccccca gcccaaagca cccgccagcg ccggcgggag cagcgcgccc     1200

ggaggaggag aggcgccgaa gagccagcgc gccccacggg acacggcgag agggagagac     1260

aggggggggg ggagcccgga gcccaacaga caggacccca gcgaggcggg agacccgcag     1320

ggagggcagg gcaccgcgga ggggccccca gagaaaacaa aagagaaggc aaaggagcga     1380

ggagcgaaaa ccaaggccga gaacacagga agaagcagaa gcccaggagc cgagcgacaa     1440

cggaagaaag ggacagcaag gcagagaaag aagaaagaag cgagaaggaa agagagaaaa     1500

aa                                                                    1502


<210>  536
<211>  2723
<212>  DNA
<213>  Homo Sapiens

<400>  536
gggcggggcg caggagcccc ggggcggagg agccggggag gcgggaggcg ggaggcggga       60

ggtgttgggg ccgttgaagc ggcctccctc ccgcccccag ccgcccggtc tggccccagc      120

cctgtcccga cccccggcct ggcccactcc gaccctaccc ggccgaaggg ttccgctgga      180

cacgcaggcg gcctccggag cagcccaagc ccatgagggc cgcgcgcccg gccgccggtg      240

ctgacgagac ggagctcctg gcccccgagg aggagcagag gatcaatgcg gttcaagaat      300

cgattccagc ggttcatgaa ccatcgagct ccagccaatg gccgctacaa gccaacttgc      360

tatgaacatg ctgctaactg ttacacacac gcattcctca ttgttccggc catcgtgggc      420

agtgccctcc tccatcggct gtctgatgac tgctgggaaa agataacagc atggatttat      480

ggaatgggac tctgtgccct cttcatcgtt tctacagtat ttcacattgt atcatggaaa      540

aagagccact taaggacagt ggagcattgt tttcacatgt gtgatagaat ggttatctat      600

ttcttcattg ctgcttctta tgctccatgg ttaaatcttc gtgaacttgg acccctggca      660

tctcatatgc gttggtttat ctggctcatg gcagctggag gaaccattta tgtatttctc      720

taccatgaaa aatataaggt ggttgaactc tttttctatc tcacaatggg attctctcca      780

gccttggtgg tgacatcaat gaacaacacc gatggacttc aggaacttgc ctgtgggggc      840

ttaatttatt gcttgggagt tgtgttcttc aagagtgatg gcatcattcc atttgcccac      900

gccatctggc acctgtttgt ggccacggca gctgcagtgc attactacgc catttggaaa      960

tacctttacc gaagtcctac ggactttatg cggcatttat gaccaatctg tactaattct     1020

ccaaaccagt attatttcaa ttatggcact tgggagtggg gtgagagcta aacattgcac     1080

agggaaagaa aaaaaataac tgcactgact ttatatcttt tgaatataat tactgtgaaa     1140

gtataaaggc tgtgttctgg aattttctgc ctcacagcaa ataaataagg tagtgaatta     1200

attattcatt ccattccact atcatgaagg actctgaata gacttggcca actgatgttt     1260

acaaaccaga cttttatatt ttaattttac agattttact acatgatttt tctaaattac     1320

tatgtcaggt tgtaaaagtc agtgcaataa caaaccttcc tttttaagaa gaaaattgtt     1380

tctattactt tcccattcac taggtaaaga atcatggaca gaacttacac tactttttac     1440

catgtttcat cttggcataa catggttctt ttttaaatag aaactttagt tttttgtaaa     1500

tttttaaaaa aatatttcat tgatatgcat ctctgcaggt cctcattcat gttgtaaatt     1560

tttgcagcaa gcagtcaaca ttccacaaac gaacaaacat tatacctctt ctgatagttt     1620

tattaagcat ggagaaattg ccaattttta aaaactgcag ttttccaaac ttttctgcca     1680

acctcttact ctgaattcag tgctgctttg ggacatatac ttgacctagc ttggtttacc     1740

agtgatggaa aagtattttg atatcattaa ctttttcaaa agatccaact ttttctctat     1800

gcctttgcca cattctcttc agggtctctt tccacagtgg ataaatgttt tttctgtatt     1860

atgacagtat tgttgtgatg gccatctgct ggaaactcct gaagagcatt atgtattaca     1920

gtgagcagtt gtattgcctg tttggtgccc aatggttaag tcattgtcac ttagctttat     1980

attgtcagtt tgatatttat tttaaattgt ggaactagat gcataaattc acatttctgc     2040

ctttcctttg catcttctca tatattgtgt tttttttttt ttttcctaga aaaaatattt     2100

aaagcattgt ttgacaggta gaaactcatg tatctgtagt ccatgagtta tatcctggct     2160

cagtggagtg atatttatgt attattttta cttttctctc agtgtcttat attaagatta     2220

acatgttgtt aatagttgct ttgttgatta atctctcttg ttggtgtttt aataaatgaa     2280

ataggcttgc ctttagatcg ggtgctgata ttgcctgttt cctagtaatg ggctgatcaa     2340

atgatcagtg gaattcttgg tttgatgata accttattaa ttgaaatttt ttactgatgt     2400

ggctttaaaa gaggtttatt ttgtatatgt ttagaactct ctgattttga tgaattatat     2460

gggaatgaga aacagaagaa gtggtatttg ctggcgagtt aaataggcaa ggtacccagt     2520

gataacacca accaaaccac tcctatctgc atgattctga acatctggat gcctgttgtt     2580

ttactgtgta tattttattt ttaatatatt aactttgtgg attcatttaa ggtctactca     2640

aaagtaacac tgtcaaaacc actaatatgt atgtaaaaat tgtgctgtat actacaataa     2700

agttgttact tggatttgtt cca                                             2723


<210>  537
<211>  238
<212>  PRT
<213>  Homo Sapiens

<400>  537

Met Arg Phe Lys Asn Arg Phe Gln Arg Phe Met Asn His Arg Ala Pro 
1               5                   10                  15      


Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr Glu His Ala Ala Asn Cys 
            20                  25                  30          


Tyr Thr His Ala Phe Leu Ile Val Pro Ala Ile Val Gly Ser Ala Leu 
        35                  40                  45              


Leu His Arg Leu Ser Asp Asp Cys Trp Glu Lys Ile Thr Ala Trp Ile 
    50                  55                  60                  


Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile Val Ser Thr Val Phe His 
65                  70                  75                  80  


Ile Val Ser Trp Lys Lys Ser His Leu Arg Thr Val Glu His Cys Phe 
                85                  90                  95      


His Met Cys Asp Arg Met Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr 
            100                 105                 110         


Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met 
        115                 120                 125             


Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe 
    130                 135                 140                 


Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr 
145                 150                 155                 160 


Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Asn Asn Thr Asp 
                165                 170                 175     


Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val 
            180                 185                 190         


Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp 
        195                 200                 205             


His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp 
    210                 215                 220                 


Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu 
225                 230                 235             


<210>  538
<211>  6276
<212>  DNA
<213>  Homo Sapiens

<400>  538
attaaattaa caccatttga aagagaacat tgttttcatc atgaatgcta ataaagatga       60

aagacttaaa gccagaagcc aagattttca cctttttcct gctttgatga tgctaagcat      120

gaccatgttg tttcttccag tcactggcac tttgaagcaa aatattccaa gactcaagct      180

aacctacaaa gacttgctgc tttcaaatag ctgtattccc tttttgggtt catcagaagg      240

actggatttt caaactcttc tcttagatga ggaaagaggc aggctgctct tgggagccaa      300

agaccacatc tttctactca gtctggttga cttaaacaaa aattttaaga agatttattg      360

gcctgctgca aaggaacggg tggaattatg taaattagct gggaaagatg ccaatacaga      420

atgtgcaaat ttcatcagag tacttcagcc ctataacaaa actcacatat atgtgtgtgg      480

aactggagca tttcatccaa tatgtgggta tattgatctt ggagtctaca aggaggatat      540

tatattcaaa ctagacacac ataatttgga gtctggcaga ctgaaatgtc ctttcgatcc      600

tcagcagcct tttgcttcag taatgacaga tgagtacctc tactctggaa cagcttctga      660

tttccttggc aaagatactg cattcactcg atcccttggg cctactcatg accaccacta      720

catcagaact gacatttcag agcactactg gctcaatgga gcaaaattta ttggaacttt      780

cttcatacca gacacctaca atccagatga tgataaaata tatttcttct ttcgtgaatc      840

atctcaagaa ggcagtacct ccgataaaac catcctttct cgagttggaa gagtttgtaa      900

gaatgatgta ggaggacaac gcagcctgat aaacaagtgg acgacttttc ttaaggccag      960

actgatttgc tcaattcctg gaagtgatgg ggcagatact tactttgatg agcttcaaga     1020

tatttattta ctccccacaa gagatgaaag aaatcctgta gtatatggag tctttactac     1080

aaccagctcc atcttcaaag gctctgctgt ttgtgtgtat agcatggctg acatcagagc     1140

agtttttaat ggtccatatg ctcataagga aagtgcagac catcgttggg tgcagtatga     1200

tgggagaatt ccttatccac ggcctggtac atgtccaagc aaaacctatg acccactgat     1260

taagtccacc cgagattttc cagatgatgt catcagtttc ataaagcggc actctgtgat     1320

gtataagtcc gtatacccag ttgcaggagg accaacgttc aagagaatca atgtggatta     1380

cagactgaca cagatagtgg tggatcatgt cattgcagaa gatggccagt acgatgtaat     1440

gtttcttgga acagacattg gaactgtcct caaagttgtc agcatttcaa aggaaaagtg     1500

gaatatggaa gaggtagtgc tggaggagtt gcagatattc aagcactcat caatcatctt     1560

gaacatggaa ttgtctctga agcagcaaca attgtacatt ggttcccgag atggattggt     1620

tcagctctcc ttgcacagat gcgacactta tgggaaagct tgcgcagact gttgtcttgc     1680

cagagacccc tactgtgcct gggatggaaa tgcatgctct cgatatgctc ctacttctaa     1740

aaggagagct agacgccaag atgtaaaata tggcgaccca atcacccagt gctgggacat     1800

cgaagacagc attagtcatg aaactgctga tgaaaaggtg atttttggca ttgaatttaa     1860

ctcaaccttt ctggaatgta tacctaaatc ccaacaagca actattaaat ggtatatcca     1920

gaggtcaggg gatgagcatc gagaggagtt gaagcccgat gaaagaatca tcaaaacgga     1980

atatgggcta ctgattcgaa gtttgcagaa gaaggattct gggatgtatt actgcaaagc     2040

ccaggagcac actttcatcc acaccatagt gaagctgact ttgaatgtca ttgagaatga     2100

acagatggaa aatacccaga gggcagagca tgaggagggg aaggtcaagg atctattggc     2160

tgagtcacgg ttgagataca aagactacat ccaaatcctt agcagcccaa acttcagcct     2220

cgaccagtac tgcgaacaga tgtggcacag ggagaagcgg agacagagaa acaagggggg     2280

cccaaagtgg aagcacatgc aggaaatgaa gaagaaacga aatcgaagac atcacagaga     2340

cctggatgag ctccctagag ctgtagccac gtagttttct acttaattta aagaaaagaa     2400

ttccttacct ataaaaacat tgccttctgt tttgtatatc ccttatagta attcataaat     2460

gcttcccatg gagttttgct aaggcacaag acaataatct gaataagaca atatgtgatg     2520

aatataagaa agggcaaaaa attcatttga accagttttc caagaacaaa tcttgcacaa     2580

gcaaagtata agaattatcc taaaaatagg gggtttacag ttgtaaatgt tttatgtttt     2640

gagttttgga atttattgtc atgtaaatag ttgagctaag caagccccga atttgatagt     2700

gtataaggtg ctttattccc tcgaatgtcc attaagcatg gaatttacca tgcagttgtg     2760

ctatgttctt atgaacagat atatcattcc tattgagaac cagctacctt gtggtaggga     2820

ataagaggtc agacacaaat taagacaact cccattatca acaggaactt tctcagtgag     2880

ccattcactc ctggagaatg gtataggaat ttggagaggt gcattatttc tttctggcca     2940

ctggggttaa atttagtgta ctacaacatt gatttactga agggcactaa tgtttccccc     3000

aggatttcta ttgactagtc aggagtaaca ggttcacaga gagaagttgg tgcttagtta     3060

tgtgtttttt agagtatata ctaagctcta cagggacaga atgcttaata aatactttaa     3120

taagatatgg gaaaatattt taataaaaca aggaaaacat aatgatgtat aatgcatcct     3180

gatgggaagg catgcagatg ggatttgtta gaagacagaa ggaaagacag ccataaattc     3240

tggctttggg gaaaactcat atccccatga aaaggaagaa caatcacaaa taaagtgaga     3300

gtaatgtaat ggagctcttt tcactagggt ataagtagct gccaatttgt aattcatctg     3360

ttaaaaaaaa tctagattat aacaaactgc tagcaaaatc tgaggaaaca taaattcttc     3420

tgaagaatca taggaagagt agacatttta tttataacca atgatatttc agtatatatt     3480

ttctctcttt taaaaaatat ttatcatact ctgtatatta tttcttttta ctgcctttat     3540

tctctcctgt atattggatt ttgtgattat atttgagtga ataggagaaa acaatatata     3600

acacacagag aattaagaaa atgacatttc tggggagtgg ggatatatat ttgttgaata     3660

acagaacgag tgtaaaattt taacaacgga aagggttaaa ttaactcttt gacatcttca     3720

ctcaaccttt tctcattgct gagttaatct gttgtaattg tagtattgtt tttgtaattt     3780

aacaataaat aagcctgcta catgtaaaaa gaaccaaact cacaatatta acataaacat     3840

ctttcatatt ttgttagtac tttcaaatgt tttcaatttg actttccctc tgaatatgca     3900

tggtgtgttt cctgtctgtt taagcagaac tcacctttcc ttcttgtaac acagaaccct     3960

tagccttctt ctgttttgcc ttttcacgcc ctttatagtg tgaaatgaaa aattagtcac     4020

ttcctcacat ggaaggcagc ttttcagaaa ataacagaca ttgctcgttt ctcatgcatt     4080

ctacatatct tgaaagaaaa gtctgtgaga aaaccctgtg attagagggc aacttaatgc     4140

aagatctgtg gctctatgtt gagagcattc tctctctgtt atttttattt tatttgcatt     4200

gcttacctat ctcaaagtag tcaaactgat atatgagatt gagtactccc ttttgatatt     4260

atactgatga atatttgtag gtgtttcact ataaggaaca gctaaggaat aattttaata     4320

aaagtgaacc agaacaaatc actcatttaa aaagtaattc agaagaacag tgtggcatga     4380

tcagacttct aattgaatag cgtaacaaca gtgtttgtaa ttatagattt gcttggacaa     4440

aatattccag gaactcatag cgagctcaaa gcaattaagt gggaacattt ttaatttaaa     4500

aaaaatttcc aaatatttgt gggtccgaca gtaatgatca aaatatgaat gactttggaa     4560

aatttacatg aagctcaagt gttaggattg acttatgaaa ataaatttta tttctatcca     4620

aatttgaatg tccaaaccat tttttagtta cttctttcta atcctagtta ttcagacaaa     4680

atttggaaac ttattttatg accacatcta atattctggc tgctttggat acaatactct     4740

tgatttatga taattagtta aaatatatta aaaatattat tagtaaaata aaatttcaca     4800

caataaaaaa caacatagag tacacatatt tatatgtatt tttaaagata aagaatatct     4860

aaaatgtgtt tttttcttag ctttttagtt gtctagaaca tttagagaaa gagtatgaat     4920

atattaaatc cacaaacaca ctatatactt cctcaccact gactatttta tcaaatttgc     4980

cttaaaataa tgaaaaagaa aagtatagtt aatggtttca aatatgctaa gaaattgact     5040

ctgcggaggg gatcttaaaa tgcctgttta ctcatgtttt cgtatttttc ttgtctctaa     5100

tacttttgtc tttgtctgcc ttgtgtgttc ttttctgaat ttcatttcag caatttatgc     5160

tgctaaatag aatcccgcat gtctgcattc atttacattc aacttattgt aaattttgag     5220

attttattta gaaatgaatt gtctaattaa tttatgtaga gtcctttttt ccaaagagct     5280

caaaacacta catccacatt attgactttt ggaaaccaac caaattactt aagaaatgga     5340

aaagtagtca cagagaaatt tagtaatttg caaaagccac aacagtagtg gaagaattaa     5400

aattcataaa gtctcatcat tctgttggct aaaataatgc tctttacaat atgctggcta     5460

caaaatggtc ttactcttga attttgcttt tggttcatat tttggttctt catattctag     5520

tatgttttgt tcctgctgaa ttttacagac tcagctaaac aataagttat tagtagtcac     5580

ttgttttcat tatcataatt gaatttccaa gaacaacttg atatcattca gctgtccaaa     5640

aaataataag agcattcatt aaatactgat tttcttaaac ttaaatgttg tatttcatat     5700

ttatttatat aatacaaatg gaaatcaaaa ctgaaatagc ctccctttag aatgtcacat     5760

ttttcttaga aaacattttg gaattggtta accttattgg gaatggataa tttagaaaca     5820

aaccaaaaaa aaaaaaagat atttgaagtg tttttatagg agatgtattt ttatcatagt     5880

aaatgatcac aattttaaat aattcatctt acaagtcagg taaaataaaa tcgattccca     5940

gattccatac attaggagtg caaagacagg atcatacaca tgacttatac ctctcattta     6000

aatattttat agtataaagt atttatggaa agggtttgag atagatgatt tttgggaaag     6060

ggcaaaatgt gtcagatgcc ctagttaatc atgtaattta attctggtat tgtgagtggt     6120

tagcaatcaa ttttgaattt ataattctgc tattttaaaa gaaatgtagt cttgtagtat     6180

gaaataatta aaaattgtta aatgtatatt ttggttgtat tataataaaa tgcaaacatg     6240

actgttctat gattataaaa aaaaaaaaaa aaaaaa                               6276


<210>  539
<211>  777
<212>  PRT
<213>  Homo Sapiens

<400>  539

Met Asn Ala Asn Lys Asp Glu Arg Leu Lys Ala Arg Ser Gln Asp Phe 
1               5                   10                  15      


His Leu Phe Pro Ala Leu Met Met Leu Ser Met Thr Met Leu Phe Leu 
            20                  25                  30          


Pro Val Thr Gly Thr Leu Lys Gln Asn Ile Pro Arg Leu Lys Leu Thr 
        35                  40                  45              


Tyr Lys Asp Leu Leu Leu Ser Asn Ser Cys Ile Pro Phe Leu Gly Ser 
    50                  55                  60                  


Ser Glu Gly Leu Asp Phe Gln Thr Leu Leu Leu Asp Glu Glu Arg Gly 
65                  70                  75                  80  


Arg Leu Leu Leu Gly Ala Lys Asp His Ile Phe Leu Leu Ser Leu Val 
                85                  90                  95      


Asp Leu Asn Lys Asn Phe Lys Lys Ile Tyr Trp Pro Ala Ala Lys Glu 
            100                 105                 110         


Arg Val Glu Leu Cys Lys Leu Ala Gly Lys Asp Ala Asn Thr Glu Cys 
        115                 120                 125             


Ala Asn Phe Ile Arg Val Leu Gln Pro Tyr Asn Lys Thr His Ile Tyr 
    130                 135                 140                 


Val Cys Gly Thr Gly Ala Phe His Pro Ile Cys Gly Tyr Ile Asp Leu 
145                 150                 155                 160 


Gly Val Tyr Lys Glu Asp Ile Ile Phe Lys Leu Asp Thr His Asn Leu 
                165                 170                 175     


Glu Ser Gly Arg Leu Lys Cys Pro Phe Asp Pro Gln Gln Pro Phe Ala 
            180                 185                 190         


Ser Val Met Thr Asp Glu Tyr Leu Tyr Ser Gly Thr Ala Ser Asp Phe 
        195                 200                 205             


Leu Gly Lys Asp Thr Ala Phe Thr Arg Ser Leu Gly Pro Thr His Asp 
    210                 215                 220                 


His His Tyr Ile Arg Thr Asp Ile Ser Glu His Tyr Trp Leu Asn Gly 
225                 230                 235                 240 


Ala Lys Phe Ile Gly Thr Phe Phe Ile Pro Asp Thr Tyr Asn Pro Asp 
                245                 250                 255     


Asp Asp Lys Ile Tyr Phe Phe Phe Arg Glu Ser Ser Gln Glu Gly Ser 
            260                 265                 270         


Thr Ser Asp Lys Thr Ile Leu Ser Arg Val Gly Arg Val Cys Lys Asn 
        275                 280                 285             


Asp Val Gly Gly Gln Arg Ser Leu Ile Asn Lys Trp Thr Thr Phe Leu 
    290                 295                 300                 


Lys Ala Arg Leu Ile Cys Ser Ile Pro Gly Ser Asp Gly Ala Asp Thr 
305                 310                 315                 320 


Tyr Phe Asp Glu Leu Gln Asp Ile Tyr Leu Leu Pro Thr Arg Asp Glu 
                325                 330                 335     


Arg Asn Pro Val Val Tyr Gly Val Phe Thr Thr Thr Ser Ser Ile Phe 
            340                 345                 350         


Lys Gly Ser Ala Val Cys Val Tyr Ser Met Ala Asp Ile Arg Ala Val 
        355                 360                 365             


Phe Asn Gly Pro Tyr Ala His Lys Glu Ser Ala Asp His Arg Trp Val 
    370                 375                 380                 


Gln Tyr Asp Gly Arg Ile Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser 
385                 390                 395                 400 


Lys Thr Tyr Asp Pro Leu Ile Lys Ser Thr Arg Asp Phe Pro Asp Asp 
                405                 410                 415     


Val Ile Ser Phe Ile Lys Arg His Ser Val Met Tyr Lys Ser Val Tyr 
            420                 425                 430         


Pro Val Ala Gly Gly Pro Thr Phe Lys Arg Ile Asn Val Asp Tyr Arg 
        435                 440                 445             


Leu Thr Gln Ile Val Val Asp His Val Ile Ala Glu Asp Gly Gln Tyr 
    450                 455                 460                 


Asp Val Met Phe Leu Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val 
465                 470                 475                 480 


Ser Ile Ser Lys Glu Lys Trp Asn Met Glu Glu Val Val Leu Glu Glu 
                485                 490                 495     


Leu Gln Ile Phe Lys His Ser Ser Ile Ile Leu Asn Met Glu Leu Ser 
            500                 505                 510         


Leu Lys Gln Gln Gln Leu Tyr Ile Gly Ser Arg Asp Gly Leu Val Gln 
        515                 520                 525             


Leu Ser Leu His Arg Cys Asp Thr Tyr Gly Lys Ala Cys Ala Asp Cys 
    530                 535                 540                 


Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Asn Ala Cys Ser 
545                 550                 555                 560 


Arg Tyr Ala Pro Thr Ser Lys Arg Arg Ala Arg Arg Gln Asp Val Lys 
                565                 570                 575     


Tyr Gly Asp Pro Ile Thr Gln Cys Trp Asp Ile Glu Asp Ser Ile Ser 
            580                 585                 590         


His Glu Thr Ala Asp Glu Lys Val Ile Phe Gly Ile Glu Phe Asn Ser 
        595                 600                 605             


Thr Phe Leu Glu Cys Ile Pro Lys Ser Gln Gln Ala Thr Ile Lys Trp 
    610                 615                 620                 


Tyr Ile Gln Arg Ser Gly Asp Glu His Arg Glu Glu Leu Lys Pro Asp 
625                 630                 635                 640 


Glu Arg Ile Ile Lys Thr Glu Tyr Gly Leu Leu Ile Arg Ser Leu Gln 
                645                 650                 655     


Lys Lys Asp Ser Gly Met Tyr Tyr Cys Lys Ala Gln Glu His Thr Phe 
            660                 665                 670         


Ile His Thr Ile Val Lys Leu Thr Leu Asn Val Ile Glu Asn Glu Gln 
        675                 680                 685             


Met Glu Asn Thr Gln Arg Ala Glu His Glu Glu Gly Lys Val Lys Asp 
    690                 695                 700                 


Leu Leu Ala Glu Ser Arg Leu Arg Tyr Lys Asp Tyr Ile Gln Ile Leu 
705                 710                 715                 720 


Ser Ser Pro Asn Phe Ser Leu Asp Gln Tyr Cys Glu Gln Met Trp His 
                725                 730                 735     


Arg Glu Lys Arg Arg Gln Arg Asn Lys Gly Gly Pro Lys Trp Lys His 
            740                 745                 750         


Met Gln Glu Met Lys Lys Lys Arg Asn Arg Arg His His Arg Asp Leu 
        755                 760                 765             


Asp Glu Leu Pro Arg Ala Val Ala Thr 
    770                 775         


<210>  540
<211>  6226
<212>  DNA
<213>  Homo Sapiens

<400>  540
agcgggtggg ggaagctggt aggcacgggc ggctccgcag tgaccggact cgggggagca       60

gataatcacc agaatgggag tgaatgactt gtggcaaatt ttggagcctg ttaagcaaca      120

catccccttg cgtaatcttg gtgggaaaac cattgcagtt gatctgagtc tctgggtgtg      180

tgaggcacag acagtcaaaa aaatgatggg cagcgtcatg aagccccacc tcaggaactt      240

attttttcgt atctcatatt taacacaaat ggatgtaaaa ctggtatttg ttatggaagg      300

ggaaccacca aagctgaaag ctgatgtcat aagcaagagg aatcagtctc ggtatgggtc      360

ttctggaaaa tcgtggtctc agaaaacagg gagatcacat tttaaatcag tcttaagaga      420

gtgcctccat atgctcgaat gcttaggaat cccctgggtt caggctgctg gggaagctga      480

agccatgtgt gcttatctca atgctggtgg tcatgtcgat ggctgcctca ccaatgatgg      540

agatactttc ctttatgggg cccagactgt ttacaggaat ttcactatga atacaaagga      600

cccacatgtt gactgttaca caatgtcatc tatcaagagt aaactaggtt tggatagaga      660

tgctctggtt ggattagcaa tacttcttgg ctgtgattat ctcccaaagg gagtccctgg      720

agttggaaaa gagcaagcat taaaacttat acagattttg aaagggcaaa gtttacttca      780

gaggtttaat cggtggaatg aaacatcttg taactctagt ccacaactgc tagtcactaa      840

aaaactggct cattgttccg tatgttccca tccaggttca cctaaggatc atgaacgtaa      900

tggatgcaga ttatgtaaaa gtgataaata ttgtgagcca catgactatg aatactgctg      960

tccttgtgag tggcaccgta cagaacatga taggcaactc agtgaagtag agaacaatat     1020

taagaagaaa gcttgctgtt gtgagggatt cccattccat gaggttattc aagaattcct     1080

tttaaacaag gataaattgg tgaaggttat caggtaccaa agacctgatt tgttattgtt     1140

tcagagattt actcttgaaa aaatggagtg gcccaatcac tatgcatgtg agaaattgct     1200

ggtacttttg acccattatg acatgataga aagaaagctt ggtagcagaa actctaatca     1260

actacagcca attcgaattg ttaagactcg aatcagaaat ggagttcatt gttttgaaat     1320

agaatgggaa aagcctgaac attatgctat ggaagataaa caacatggag aatttgcttt     1380

attaacaatt gaggaagaat cattgtttga agcagcatat cctgagatcg ttgctgttta     1440

ccaaaaacaa aagttagaaa ttaaagggaa gaaacaaaaa cgtattaagc ctaaagaaaa     1500

caatttgcca gaaccagatg aagtaatgag ctttcagtca cacatgactt taaaacccac     1560

atgtgaaatc tttcataagc agaattccaa gttaaattcg gggatttccc ctgatcctac     1620

attaccacag gaatctattt ctgcctcatt gaatagcttg cttttaccta aaaatactcc     1680

atgtttgaat gcacaagaac agttcatgtc ttctctaaga cctttggcta tacagcaaat     1740

taaagctgtc agtaagtctc taatttcaga atctagtcaa cccaatacct catctcataa     1800

tatatccgtg attgctgatc tacacttgag cactattgac tgggaaggta cttcttttag     1860

taattctcca gctattcaaa ggaatacttt ttctcatgat ttaaaatcag aagttgaatc     1920

agagctatca gccatccctg atggctttga aaatatccca gaacaactgt cctgtgaatc     1980

agaaaggtac actgcaaaca taaagaaagt gttggatgag gattctgatg ggattagtcc     2040

tgaagagcat ctactttctg gcattactga tttatgtctt caggatttgc ctttaaagga     2100

acgaatattt acaaaattat catatcctca ggataatcta caaccagatg tcaacctgaa     2160

aactttgtcc atacttagtg taaaagaatc ttgtattgct aacagtggtt ctgattgtac     2220

atcacatctt tcaaaggatc ttccaggaat tcccttgcaa aatgaatcca gagactctaa     2280

aattctaaaa ggagaccagc tgcttcaaga agactataaa gtcaatactt ctgtccctta     2340

ttctgtcagt aacacagtgg taaagacctg caatgttaga ccaccaaata ctgctttaga     2400

tcatagtaga aaagttgata tgcaaaccac tcggaaaatt ttaatgaaga agagtgtttg     2460

ccttgacaga cattcctctg atgaacaaag tgccccagtg tttgggaaag ctaagtacac     2520

aactcaaaga atgaagcaca gttctcaaaa gcataattca tcccatttca aagaaagtgg     2580

ccataacaag ttgagtagcc ctaagataca tattaaagaa actgaacagt gtgtcagatc     2640

ttatgaaaca gctgaaaatg aagaaagctg tttcccagat tcaacaaaaa gttctctgag     2700

ttctctacaa tgtcataaga aagaaaacaa ctctggtact tgtttggata gccctcttcc     2760

tttacgccag agattaaaac taagattcca aagcacttga aatttaaaac acttaggtat     2820

aacttaacta ttttagtact atcagcaata gcagagacag agggaaggta tctagttcat     2880

gtgtggtaaa aattttaatg ttctctgtgt catgaaacac ttgccatttt aatcaaagtt     2940

gtaattttta aaaagtcacc taaaactctg gttttaaaag atcctctgta ttgaaaactt     3000

ctgataatgt atgtcattat gtccttacta ttccttaatt gtagttttaa aatattggta     3060

tagtacttga cagagtaaat acttcatctg attgttcatt tttacttttt cttccacaag     3120

cctctaaagt atttatattc cagcttgttc ccaagaggat aattctttat acttctcttc     3180

attcttttaa ggccttgcaa ggtcttccgt tataactcgc tttcctaaaa gctattttct     3240

ccctcagtgt gaagatacct ttagtgtgct cttccacttt ggaaggccat gcaaggtgtt     3300

ccattataac tctttttcct aagagttata ttctccctca gtttgaagat acctttagtg     3360

tgctcttcca cttttggtgt cttagtctct tttgaggggc aaaaatagaa aaggagagaa     3420

gatgtcagta tgtttagtaa aaatcatgct cgtaatggct gaataaactg agcaaagtaa     3480

ctccttatgt atccccagaa gttcacaggt atatcgggtg gaaaaagatt tggaaaatca     3540

aatgtataac caaaaggatt agaaactagc ccaggatcac gtagctaact aataatcctg     3600

tgggaatcag ttttcttgcc tgctaatttt tttatttttc tattttttcc ttctatagca     3660

cttttccccc ttttgttttg aatctatgca atattgactt taataccacc aaatattaag     3720

tcatgcatta atttaggtcg cactcaaaaa ttctagagag gcatccagat tgaaaaggaa     3780

aatggtgtct gcagatgaca agattgtatg catcaaaaat tctaagaaat ccactagaaa     3840

actattaaaa ctgataaagc gagttcatcc aggtcgtaga atacaagacc aatgtgcaat     3900

gatcattgca ttttgttttt gtttgtttgt ttttttttga gacagagtct cactcttgtc     3960

gagactgggg tgtagtggcg ccatcttggc tcactgcaac ctctgcctcc caggttcacg     4020

caattcacat gcctcagcca cctgagtagc agggattaca ggtgtgtgcc accatgcctg     4080

gctaattttt agtattttta gtagagatgg gattttccct tgttggtcag gctagtcatg     4140

aactcctggc ctcaagcgat ccacccatct tggcctccca gagtgctggg attacaggtg     4200

tgaatcacca tactcagcct caattgtatt tctgtacacc tctaaataaa tggaaataca     4260

ttccatgttc atgaatcaga agacataaga tgaccatact ccccaaactg atctacaggt     4320

taaatgtaat tcccattaat tccagctggt ttctttgctg attctaaaat tcatatggaa     4380

atttcaggaa cacagaatat taggaagaat cttgaaagag tttgaatgac ccacccttcc     4440

tgattttaag tatacagaac tacagtaatg aatgtgttgt actggtataa aggtagacat     4500

ataggtcaat atagatcaat ggcatagaat tgagaattca gaaaaaaagc cttcacgttt     4560

atggtcagtt gattttaaac cagagtgcca agacaattca atgggaaaag gaaacagtct     4620

ttgaaccaac tgtcttctgg atctattgga tatctatgta aaaaagagtg acatttgatt     4680

cctacttcac atgatattta agaagtaact taagatggat caaataccta aatgtaagct     4740

aaagctataa aactcttaga agaaaacata gacgtaaatc tttgtgactt tggattaggc     4800

aaggatttct taaatatacc caaagcatag gcaacaaaag agaatacaca aactggactt     4860

catcaaaact aaaaactgtt gtttgaaatg acaccatcaa gaaagtgaaa agacagctta     4920

cagaatggga gaaaatattt gcaaatcata aatgtgataa gggacttgta tcttggtggt     4980

atataaagaa ctcgtaactc aattataaaa agacaacttt gaaatgggca aaatagctca     5040

acaggctttt ctgcaaagaa gaaatacaaa tgaccaagaa gcacatttaa aaattttcag     5100

tactattact catcaggaaa atgcaaatca aaaccacaag acacccaatg tctacaatca     5160

aaaagataat aactagtatt gatgaggatg tggagaaatt gaaattctca taacatgctg     5220

gtaggaatgt aaaatggggc agccactttg gaaaaagtct ggtagttctt caaatggtta     5280

aatgtagagt tacgatatga tccagcaatt cctctcccag gtatataccc aagataaatg     5340

aaaacttata tccacataaa aacctgtgca caaatgtcca tagcagcgtt attcataata     5400

gcctaaaagt ggaaacaatc ccagttccag aatgaggaag gggagaaact aatgtgtatt     5460

agctattgtg tgctaagcat tcaactagat tatttacaaa ccttgtatca tctcaactct     5520

ttaaggactg tattgcaatg ttttgaatat tcagagagaa aaaagtcgtt gctaaaacat     5580

tttccaaggt tctgcttatt ctgatttgtt cagtcgtggc tgtgatagtt caggaccatc     5640

tagaccaggt aaataaaata tctagaggca ttcttgagat tgtatgagat gaaaataaca     5700

aaattagttg ggagtggcca gtctgagttc attttgctat atagctcagg agtccccaac     5760

ccctgggcta tggacaggta ccagtccatc acctgtcagg aaccggcctg cacagcaggt     5820

gttgagcggc atgcaagcga gaattaccgc ctgagctctg cctcctgtca gatcagcggt     5880

ggcattagag tctcatagga gcatgaaccc tattgtgaac tacgcatgcg aggatctagt     5940

ttgtgcactc ctactgagaa tctaatgcct gatgatataa ggtggaacag cttcatccca     6000

cagccatctc cccctcatca tccgtggaaa aactgttttc cacgaaagtg gtcctcggtg     6060

ccagaaaggt tggggactgc tgatatacct aatataggca taagtgtaaa attatagttc     6120

ctcctcctca aggatttctc tgttttcatt gtccaggtta taccaattct ttttaaagca     6180

ttccatgttc ttgttccttg atgtggtcat gttatcactt gtaaat                    6226


<210>  541
<211>  908
<212>  PRT
<213>  Homo Sapiens

<400>  541

Met Gly Val Asn Asp Leu Trp Gln Ile Leu Glu Pro Val Lys Gln His 
1               5                   10                  15      


Ile Pro Leu Arg Asn Leu Gly Gly Lys Thr Ile Ala Val Asp Leu Ser 
            20                  25                  30          


Leu Trp Val Cys Glu Ala Gln Thr Val Lys Lys Met Met Gly Ser Val 
        35                  40                  45              


Met Lys Pro His Leu Arg Asn Leu Phe Phe Arg Ile Ser Tyr Leu Thr 
    50                  55                  60                  


Gln Met Asp Val Lys Leu Val Phe Val Met Glu Gly Glu Pro Pro Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Val Ile Ser Lys Arg Asn Gln Ser Arg Tyr Gly Ser 
                85                  90                  95      


Ser Gly Lys Ser Trp Ser Gln Lys Thr Gly Arg Ser His Phe Lys Ser 
            100                 105                 110         


Val Leu Arg Glu Cys Leu His Met Leu Glu Cys Leu Gly Ile Pro Trp 
        115                 120                 125             


Val Gln Ala Ala Gly Glu Ala Glu Ala Met Cys Ala Tyr Leu Asn Ala 
    130                 135                 140                 


Gly Gly His Val Asp Gly Cys Leu Thr Asn Asp Gly Asp Thr Phe Leu 
145                 150                 155                 160 


Tyr Gly Ala Gln Thr Val Tyr Arg Asn Phe Thr Met Asn Thr Lys Asp 
                165                 170                 175     


Pro His Val Asp Cys Tyr Thr Met Ser Ser Ile Lys Ser Lys Leu Gly 
            180                 185                 190         


Leu Asp Arg Asp Ala Leu Val Gly Leu Ala Ile Leu Leu Gly Cys Asp 
        195                 200                 205             


Tyr Leu Pro Lys Gly Val Pro Gly Val Gly Lys Glu Gln Ala Leu Lys 
    210                 215                 220                 


Leu Ile Gln Ile Leu Lys Gly Gln Ser Leu Leu Gln Arg Phe Asn Arg 
225                 230                 235                 240 


Trp Asn Glu Thr Ser Cys Asn Ser Ser Pro Gln Leu Leu Val Thr Lys 
                245                 250                 255     


Lys Leu Ala His Cys Ser Val Cys Ser His Pro Gly Ser Pro Lys Asp 
            260                 265                 270         


His Glu Arg Asn Gly Cys Arg Leu Cys Lys Ser Asp Lys Tyr Cys Glu 
        275                 280                 285             


Pro His Asp Tyr Glu Tyr Cys Cys Pro Cys Glu Trp His Arg Thr Glu 
    290                 295                 300                 


His Asp Arg Gln Leu Ser Glu Val Glu Asn Asn Ile Lys Lys Lys Ala 
305                 310                 315                 320 


Cys Cys Cys Glu Gly Phe Pro Phe His Glu Val Ile Gln Glu Phe Leu 
                325                 330                 335     


Leu Asn Lys Asp Lys Leu Val Lys Val Ile Arg Tyr Gln Arg Pro Asp 
            340                 345                 350         


Leu Leu Leu Phe Gln Arg Phe Thr Leu Glu Lys Met Glu Trp Pro Asn 
        355                 360                 365             


His Tyr Ala Cys Glu Lys Leu Leu Val Leu Leu Thr His Tyr Asp Met 
    370                 375                 380                 


Ile Glu Arg Lys Leu Gly Ser Arg Asn Ser Asn Gln Leu Gln Pro Ile 
385                 390                 395                 400 


Arg Ile Val Lys Thr Arg Ile Arg Asn Gly Val His Cys Phe Glu Ile 
                405                 410                 415     


Glu Trp Glu Lys Pro Glu His Tyr Ala Met Glu Asp Lys Gln His Gly 
            420                 425                 430         


Glu Phe Ala Leu Leu Thr Ile Glu Glu Glu Ser Leu Phe Glu Ala Ala 
        435                 440                 445             


Tyr Pro Glu Ile Val Ala Val Tyr Gln Lys Gln Lys Leu Glu Ile Lys 
    450                 455                 460                 


Gly Lys Lys Gln Lys Arg Ile Lys Pro Lys Glu Asn Asn Leu Pro Glu 
465                 470                 475                 480 


Pro Asp Glu Val Met Ser Phe Gln Ser His Met Thr Leu Lys Pro Thr 
                485                 490                 495     


Cys Glu Ile Phe His Lys Gln Asn Ser Lys Leu Asn Ser Gly Ile Ser 
            500                 505                 510         


Pro Asp Pro Thr Leu Pro Gln Glu Ser Ile Ser Ala Ser Leu Asn Ser 
        515                 520                 525             


Leu Leu Leu Pro Lys Asn Thr Pro Cys Leu Asn Ala Gln Glu Gln Phe 
    530                 535                 540                 


Met Ser Ser Leu Arg Pro Leu Ala Ile Gln Gln Ile Lys Ala Val Ser 
545                 550                 555                 560 


Lys Ser Leu Ile Ser Glu Ser Ser Gln Pro Asn Thr Ser Ser His Asn 
                565                 570                 575     


Ile Ser Val Ile Ala Asp Leu His Leu Ser Thr Ile Asp Trp Glu Gly 
            580                 585                 590         


Thr Ser Phe Ser Asn Ser Pro Ala Ile Gln Arg Asn Thr Phe Ser His 
        595                 600                 605             


Asp Leu Lys Ser Glu Val Glu Ser Glu Leu Ser Ala Ile Pro Asp Gly 
    610                 615                 620                 


Phe Glu Asn Ile Pro Glu Gln Leu Ser Cys Glu Ser Glu Arg Tyr Thr 
625                 630                 635                 640 


Ala Asn Ile Lys Lys Val Leu Asp Glu Asp Ser Asp Gly Ile Ser Pro 
                645                 650                 655     


Glu Glu His Leu Leu Ser Gly Ile Thr Asp Leu Cys Leu Gln Asp Leu 
            660                 665                 670         


Pro Leu Lys Glu Arg Ile Phe Thr Lys Leu Ser Tyr Pro Gln Asp Asn 
        675                 680                 685             


Leu Gln Pro Asp Val Asn Leu Lys Thr Leu Ser Ile Leu Ser Val Lys 
    690                 695                 700                 


Glu Ser Cys Ile Ala Asn Ser Gly Ser Asp Cys Thr Ser His Leu Ser 
705                 710                 715                 720 


Lys Asp Leu Pro Gly Ile Pro Leu Gln Asn Glu Ser Arg Asp Ser Lys 
                725                 730                 735     


Ile Leu Lys Gly Asp Gln Leu Leu Gln Glu Asp Tyr Lys Val Asn Thr 
            740                 745                 750         


Ser Val Pro Tyr Ser Val Ser Asn Thr Val Val Lys Thr Cys Asn Val 
        755                 760                 765             


Arg Pro Pro Asn Thr Ala Leu Asp His Ser Arg Lys Val Asp Met Gln 
    770                 775                 780                 


Thr Thr Arg Lys Ile Leu Met Lys Lys Ser Val Cys Leu Asp Arg His 
785                 790                 795                 800 


Ser Ser Asp Glu Gln Ser Ala Pro Val Phe Gly Lys Ala Lys Tyr Thr 
                805                 810                 815     


Thr Gln Arg Met Lys His Ser Ser Gln Lys His Asn Ser Ser His Phe 
            820                 825                 830         


Lys Glu Ser Gly His Asn Lys Leu Ser Ser Pro Lys Ile His Ile Lys 
        835                 840                 845             


Glu Thr Glu Gln Cys Val Arg Ser Tyr Glu Thr Ala Glu Asn Glu Glu 
    850                 855                 860                 


Ser Cys Phe Pro Asp Ser Thr Lys Ser Ser Leu Ser Ser Leu Gln Cys 
865                 870                 875                 880 


His Lys Lys Glu Asn Asn Ser Gly Thr Cys Leu Asp Ser Pro Leu Pro 
                885                 890                 895     


Leu Arg Gln Arg Leu Lys Leu Arg Phe Gln Ser Thr 
            900                 905             


<210>  542
<211>  1502
<212>  RNA
<213>  Homo Sapiens

<400>  542
ggaggggcgg gcggccccag gcgggcgggc gcagggcgca gggcgccgac cgcggagagg       60

gggccccggg cgcgaggcgg agcccggcgc gcagccaggc gggggggccc ccggcaggcg      120

cagacccccg gcccgggagc cgcagcagga ccggccagga ggcgccaaga ggggagcccc      180

acccgggcga caggcccacc gcgcccacga ggaccagcgg ccgccggcgg cgggggcgcg      240

gcgacccacc ggccccgagg gccagcgcaa caccgcccaa caccagagcg gcgcgccacg      300

accgcgcgac cgcagggcgc accagggggg gcagcgacgg caggacagca ggacggccac      360

gagacggggc agaggccgcg gccaacggga ggagacgaag gacagaaggc acgcaacacc      420

gcggcccgca acaggaagac aaggcagcgg ggaacacaac agccagccac gcccggagga      480

ccagggggag agggaggaag aaggccaagg aggccgcacc cgaggccaga caaaacacca      540

aacagcaaaa cgagaggaaa gcaagccgac ccaaacgacc accgacagga agacaagaag      600

accagagaac aaacaaacca cagagggaga agggacccag ggaacacaac ccccagacca      660

cgaccagcca caagaggcga cgggcccagc caacgaagac gcggagcaag caggagagga      720

accaggagaa aagcgggaga gcgggggccc cagccaacgc aaaaacggcc ccggaagacg      780

gagggcagca cccgacccaa accgacaagc aagacccgga agcaagaaag gaggagaaag      840

gaggagcgca gagcgagggg accgaagacc aggccaaaag gccggagccc cgaccccggc      900

cacagcgcca accccgcacc aaccacagag ggggccgcgg ggggaggaga gccaaccagc      960

aggcccggac agagagacac gggaacacgg agcaaagaaa aaaacccgac aaaagaagaa     1020

aagaagggca aagacccaac ccggaaaaaa aacagccgag ggccaacaag aaaccgaaac     1080

ggaaagaaga aaaggaacac acagaggagg cgagaagcca aggccagggg caaacagcca     1140

gagaagacgc gaagccccca gcccaaagca cccgccagcg ccggcgggag cagcgcgccc     1200

ggaggaggag aggcgccgaa gagccagcgc gccccacggg acacggcgag agggagagac     1260

aggggggggg ggagcccgga gcccaacaga caggacccca gcgaggcggg agacccgcag     1320

ggagggcagg gcaccgcgga ggggccccca gagaaaacaa aagagaaggc aaaggagcga     1380

ggagcgaaaa ccaaggccga gaacacagga agaagcagaa gcccaggagc cgagcgacaa     1440

cggaagaaag ggacagcaag gcagagaaag aagaaagaag cgagaaggaa agagagaaaa     1500

aa                                                                    1502


<210>  543
<211>  2581
<212>  DNA
<213>  Homo Sapiens

<400>  543
ccggggccag ggaccagtgg tgggaggagg ctgcggcgct agatgcggac acctggaccg       60

ccgcgccgag gctcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg      120

tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc      180

tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact      240

tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc      300

agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca      360

tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg      420

gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc      480

acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga      540

tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc      600

gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga      660

tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg      720

ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc      780

actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga      840

tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca      900

gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg      960

actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc     1020

tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca     1080

tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat     1140

acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca     1200

tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc     1260

agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg     1320

caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca     1380

acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct     1440

atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca     1500

tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca     1560

cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc     1620

tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct     1680

tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca     1740

ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc     1800

ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg     1860

agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt     1920

gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt     1980

ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg     2040

tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag     2100

accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca     2160

gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc     2220

agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac     2280

tgcatagatt gatcaaagtg taaacaccat agggacccat tctacacaga gcaggactgc     2340

acagcgtcct gtccacaccc agctcagcat ttccacacca agcagcaaca gcaaatcacg     2400

accactgata gatgtctatt cttgttggag acatgggatg attattttct gttctatttg     2460

tgcttagtcc aattccttgc acatagtagg tacccaattc aattactatt gaatgaatta     2520

agaattggtt gccataaaaa taaatcagtt catttaaaat gaaaaaaaaa aaaaaaaaaa     2580

a                                                                     2581


<210>  544
<211>  674
<212>  PRT
<213>  Homo Sapiens

<400>  544

Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala 
1               5                   10                  15      


Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly Ser Ala Gly Cys 
            20                  25                  30          


Ser Glu Lys His Leu Leu Asp Lys Pro Phe Tyr Asn Asp Phe Glu Arg 
        35                  40                  45              


Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu 
    50                  55                  60                  


Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Trp Leu Asn Asp Asp 
65                  70                  75                  80  


Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr Ile 
                85                  90                  95      


Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val Leu 
            100                 105                 110         


Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu 
        115                 120                 125             


Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg 
    130                 135                 140                 


Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys 
145                 150                 155                 160 


His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val 
                165                 170                 175     


Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn 
            180                 185                 190         


Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp Phe 
        195                 200                 205             


Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Met 
    210                 215                 220                 


Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly 
225                 230                 235                 240 


Cys Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys Leu 
                245                 250                 255     


Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser 
            260                 265                 270         


Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe Glu 
        275                 280                 285             


Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu Gln 
    290                 295                 300                 


Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys 
305                 310                 315                 320 


Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu Asn 
                325                 330                 335     


Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala Lys 
            340                 345                 350         


Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr His 
        355                 360                 365             


Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr 
    370                 375                 380                 


Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala His 
385                 390                 395                 400 


Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Ile 
                405                 410                 415     


Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly 
            420                 425                 430         


His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala Ser 
        435                 440                 445             


Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys Glu 
    450                 455                 460                 


Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu 
465                 470                 475                 480 


Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu Gly 
                485                 490                 495     


Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn Asp 
            500                 505                 510         


Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro Lys 
        515                 520                 525             


Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val Ile 
    530                 535                 540                 


Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp 
545                 550                 555                 560 


Trp Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro 
                565                 570                 575     


Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu 
            580                 585                 590         


Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu 
        595                 600                 605             


Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu 
    610                 615                 620                 


His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg Lys 
625                 630                 635                 640 


Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys 
                645                 650                 655     


Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val 
            660                 665                 670         


Ala Ile 
        


<210>  545
<211>  466
<212>  DNA
<213>  Homo Sapiens

<400>  545
gggaggagag aaaagccatg gccgacaagg tcctgaagga gaagagaaag cagtttatcc       60

gttcagtggg cgaaggtaca ataaatggct tactgggtga attattggag acaagggtgc      120

tgagccagga agagatagag atagtaaaat gtgaaaatgc tacagttatg gataaggccc      180

gagctttgct tgactctgtt attcggaaag gggctccagc atgccaaatt tgcatcacat      240

acatttgtga agaagacagt cacctggcag ggacgctggg actctcagca ggtccaacat      300

ctggaaatca ccttactaca caagattctc aaatagtact tccttcctag gttcaacttt      360

catttgagca gccagatgat aaagcacaga tgcccagcac tgaaagagtt acttcgacaa      420

gacgtttcta tctcttccca gtacattaaa ataaggaagc tgtatg                     466


<210>  546
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  546

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Gln Phe Ile Arg Ser 
1               5                   10                  15      


Val Gly Glu Gly Thr Ile Asn Gly Leu Leu Gly Glu Leu Leu Glu Thr 
            20                  25                  30          


Arg Val Leu Ser Gln Glu Glu Ile Glu Ile Val Lys Cys Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Ala Arg Ala Leu Leu Asp Ser Val Ile Arg Lys 
    50                  55                  60                  


Gly Ala Pro Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser His Leu Ala Gly Thr Leu Gly Leu Ser Ala Gly Pro Thr Ser Gly 
                85                  90                  95      


Asn His Leu Thr Thr Gln Asp Ser Gln Ile Val Leu Pro Ser 
            100                 105                 110 


<210>  547
<211>  5810
<212>  DNA
<213>  Homo Sapiens

<400>  547
aacgggctca ttcagcggtc gcgagctgcc cgcgaggggg agcggccgga cggagagcgc       60

gacccgtccc gggggtgggg ccgggcgcag cggcgagagg aggcgaaggt ggctgcggta      120

gcagcagcgc ggcagcctcg gacccagccc ggagcgcagg gcggccgctg caggtccccg      180

ctcccctccc cgtgcgtccg cccatggccg ccgccgggca gctgtgcttg ctctacctgt      240

cggcggggct cctgtcccgg ctcggcgcag ccttcaactt ggacactcgg gaggacaacg      300

tgatccggaa atatggagac cccgggagcc tcttcggctt ctcgctggcc atgcactggc      360

aactgcagcc cgaggacaag cggctgttgc tcgtgggggc cccgcgggca gaagcgcttc      420

cactgcagag agccaacaga acgggagggc tgtacagctg cgacatcacc gcccgggggc      480

catgcacgcg gatcgagttt gataacgatg ctgaccccac gtcagaaagc aaggaagatc      540

agtggatggg ggtcaccgtc cagagccaag gtccaggggg caaggtcgtg acatgtgctc      600

accgatatga aaaaaggcag catgttaata cgaagcagga atcccgagac atctttgggc      660

ggtgttatgt cctgagtcag aatctcagga ttgaagacga tatggatggg ggagattgga      720

gcttttgtga tgggcgattg agaggccatg agaaatttgg ctcttgccag caaggtgtag      780

cagctacttt tactaaagac tttcattaca ttgtatttgg agccccgggt acttataact      840

ggaaagggat tgttcgtgta gagcaaaaga ataacacttt ttttgacatg aacatctttg      900

aagatgggcc ttatgaagtt ggtggagaga ctgagcatga tgaaagtctc gttcctgttc      960

ctgctaacag ttacttaggt ttttctttgg actcagggaa aggtattgtt tctaaagatg     1020

agatcacttt tgtatctggt gctcccagag ccaatcacag tggagccgtg gttttgctga     1080

agagagacat gaagtctgca catctcctcc ctgagcacat attcgatgga gaaggtctgg     1140

cctcttcatt tggctatgat gtggcggtgg tggacctcaa caaggatggg tggcaagata     1200

tagttattgg agccccacag tattttgata gagatggaga agttggaggt gcagtgtatg     1260

tctacatgaa ccagcaaggc agatggaata atgtgaagcc aattcgtctt aatggaacca     1320

aagattctat gtttggcatt gcagtaaaaa atattggaga tattaatcaa gatggctacc     1380

cagatattgc agttggagct ccgtatgatg acttgggaaa ggtttttatc tatcatggat     1440

ctgcaaatgg aataaatacc aaaccaacac aggttctcaa gggtatatca ccttattttg     1500

gatattcaat tgctggaaac atggaccttg atcgaaattc ctaccctgat gttgctgttg     1560

gttccctctc agattcagta actattttca gatcccggcc tgtgattaat attcagaaaa     1620

ccatcacagt aactcctaac agaattgacc tccgccagaa aacagcgtgt ggggcgccta     1680

gtgggatatg cctccaggtt aaatcctgtt ttgaatatac tgctaacccc gctggttata     1740

atccttcaat atcaattgtg ggcacacttg aagctgaaaa agaaagaaga aaatctgggc     1800

tatcctcaag agttcagttt cgaaaccaag gttctgagcc caaatatact caagaactaa     1860

ctctgaagag gcagaaacag aaagtgtgca tggaggaaac cctgtggcta caggataata     1920

tcagagataa actgcgtccc attcccataa ctgcctcagt ggagatccaa gagccaagct     1980

ctcgtaggcg agtgaattca cttccagaag ttcttccaat tctgaattca gatgaaccca     2040

agacagctca tattgatgtt cacttcttaa aagagggatg tggagacgac aatgtatgta     2100

acagcaacct taaactagaa tataaatttt gcacccgaga aggaaatcaa gacaaatttt     2160

cttatttacc aattcaaaaa ggtgtaccag aactagttct aaaagatcag aaggatattg     2220

ctttagaaat aacagtgaca aacagccctt ccaacccaag gaatcccaca aaagatggcg     2280

atgacgccca tgaggctaaa ctgattgcaa cgtttccaga cactttaacc tattctgcat     2340

atagagaact gagggctttc cctgagaaac agttgagttg tgttgccaac cagaatggct     2400

cgcaagctga ctgtgagctc ggaaatcctt ttaaaagaaa ttcaaatgtc actttttatt     2460

tggttttaag tacaactgaa gtcacctttg acaccccaga tctggatatt aatctgaagt     2520

tagaaacaac aagcaatcaa gataatttgg ctccaattac agctaaagca aaagtggtta     2580

ttgaactgct tttatcggtc tcgggagttg ctaaaccttc ccaggtgtat tttggaggta     2640

cagttgttgg cgagcaagct atgaaatctg aagatgaagt gggaagttta atagagtatg     2700

aattcagggt aataaactta ggtaaacctc ttacaaacct cggcacagca accttgaaca     2760

ttcagtggcc aaaagaaatt agcaatggga aatggttgct ttatttggtg aaagtagaat     2820

ccaaaggatt ggaaaaggta acttgtgagc cacaaaagga gataaactcc ctgaacctaa     2880

cggagtctca caactcaaga aagaaacggg aaattactga aaaacagata gatgataaca     2940

gaaaattttc tttatttgct gaaagaaaat accagactct taactgtagc gtgaacgtga     3000

actgtgtgaa catcagatgc ccgctgcggg ggctggacag caaggcgtct cttattttgc     3060

gctcgaggtt atggaacagc acatttctag aggaatattc caaactgaac tacttggaca     3120

ttctcatgcg agccttcatt gatgtgactg ctgctgccga aaatatcagg ctgccaaatg     3180

caggcactca ggttcgagtg actgtgtttc cctcaaagac tgtagctcag tattcgggag     3240

taccttggtg gatcatccta gtggctattc tcgctgggat cttgatgctt gctttattag     3300

tgtttatact atggaagtgt ggtttcttca agagaaataa gaaagatcat tatgatgcca     3360

catatcacaa ggctgagatc catgctcagc catctgataa agagaggctt acttctgatg     3420

catagtattg atctacttct gtaattgtgt ggattcttta aacgctctag gtacgatgac     3480

agtgttcccc gataccatgc tgtaaggatc cggaaagaag agcgagagat caaagatgaa     3540

aagtatattg ataaccttga aaaaaaacag tggatcacaa agtggaacga aaatgaaagc     3600

tactcatagc gggggcctaa aaaaaaaaag cttcacagta cccaaactgc tttttccaac     3660

tcagaaattc aatttggatt taaaagcctg ctcaatccct gaggactgat ttcagagtga     3720

ctacacacag tacgaaccta cagttttaac tgtggatatt gttacgtagc ctaaggctcc     3780

tgttttgcac agccaaattt aaaactgttg gaatggattt ttctttaact gccgtaattt     3840

aactttctgg gttgccttta tttttggcgt ggctgactta catcatgtgt tggggaaggg     3900

cctgcccagt tgcactcagg tgacatcctc cagatagtgt agctgaggag gcacctacac     3960

tcacctgcac taacagagtg gccgtcctaa cctcgggcct gctgcgcaga cgtccatcac     4020

gttagctgtc ccacatcaca agactatgcc attggggtag ttgtgtttca acggaaagtg     4080

ctgtcttaaa ctaaatgtgc aatagaaggt gatgttgcca tcctaccgtc ttttcctgtt     4140

tcctagctgt gtgaatacct gctcacgtca aatgcataca agtttcattc tccctttcac     4200

taaaacacac aggtgcaaca gacttgaatg ctagttatac ttatttgtat atggtattta     4260

ttttttcttt tctttacaaa ccattttgtt attgactaac aggccaaaga gtctccagtt     4320

tacccttcag gttggtttaa tcaatcagaa ttagagcatg ggaggtcatc actttgacct     4380

aaattattta ctgcaaaaag aaaatcttta taaatgtacc agagagagtt gttttaataa     4440

cttatctata aactataacc tctccttcat gacagcctcc accccacaac ccaaaaggtt     4500

taagaaatag aattataact gtaaagatgt ttatttcagg cattggatat tttttacttt     4560

agaagcctgc ataatgtttc tggatttcat actgtaacat tcaggaattc ttggagaaaa     4620

tgggtttatt cactgaactc tagtgcggtt tactcactgc tgcaaatact gtatattcag     4680

gacttgaaag aaatggtgaa tgcctatggt ggatccaaac tgatccagta taagactact     4740

gaatctgcta ccaaaacagt taatcagtga gtcgatgttc tattttttgt tttgtttcct     4800

cccctatctg tattcccaaa aattactttg gggctaattt aacaagaact ttaaattgtg     4860

ttttaattgt aaaaatggca gggggtggaa ttattactct atacattcaa cagagactga     4920

atagatatga aagctgattt tttttaatta ccatgcttca caatgttaag ttatatgggg     4980

agcaacagca aacaggtgct aatttgtttt ggatatagta taagcagtgt ctgtgttttg     5040

aaagaataga acacagtttg tagtgccact gttgttttgg gggggctttt ttcttttcgg     5100

aaatcttaaa ccttaagata ctaaggacgt tgttttggtt gtactttgga attcttagtc     5160

acaaaatata ttttgtttac aaaaatttct gtaaaacagg ttataacagt gtttaaagtc     5220

tcagtttctt gcttggggaa cttgtgtccc taatgtgttt agattgctag attgctaagg     5280

agctgatact ttgacagtgt ttttagacct gtgttactaa aaaaaagatg aatgtcctga     5340

aaagggtgtt gggagggtgg ttcaacaaag aaacaaagat gttatggtgt ttagatttat     5400

ggttgttaaa aatgtcatct caagtcaagt cactggtctg tttgcatttg atacattttt     5460

gtactaacta gcattgtaaa attatttcat gattagaaat tacctgtgga tatttgtata     5520

aaagtgtgaa ataaattttt tataaaagtg ttcattgttt cgtaacacag cattgtatat     5580

gtgaagcaaa ctctaaaatt ataaatgaca acctgaatta tctatttcat caaaccaaag     5640

ttcagtgttt ttatttttgg tgtctcatgt aatctcagat cagccaaaga tactagtgcc     5700

aaagcaatgg gattcggggt ttttttctgt tttcgctcta tgtaggtgat cctcaagtct     5760

ttcattttcc ttctttatga ttaaaagaaa cctacaggta tttaacaacc                5810


<210>  548
<211>  1073
<212>  PRT
<213>  Homo Sapiens

<400>  548

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Asn  Lys Lys Asp His Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Tyr His  Lys Ala Glu Ile His  Ala Gln Pro Ser Asp  Lys Glu Arg 
    1055                 1060                 1065             


Leu Thr  Ser Asp Ala 
    1070             


<210>  549
<211>  758
<212>  DNA
<213>  Homo Sapiens

<400>  549
gtcctgtgaa gcaatagcca ggggctaaag caaaccccag cccacaccct ggcaggcagc       60

cagggatggg tggatcagga aggctcctgg ttgggctttt gcatcaggct caggctgggc      120

ataaaggagg ctcctgtggg ctagagggag gcagacatgg ggaccatgaa gacccaaagg      180

gatggccact ccctggggcg gtggtcactg gtgctcctgc tgctgggcct ggtgatgcct      240

ctggccatca ttgcccaggt cctcagctac aaggaagctg tgcttcgtgc tatagatggc      300

atcaaccagc ggtcctcgga tgctaacctc taccgcctcc tggacctgga ccccaggccc      360

acgatggatg gggacccaga cacgccaaag cctgtgagct tcacagtgaa ggagacagtg      420

tgccccagga cgacacagca gtcaccagag gattgtgact tcaagaagga cgggctggtg      480

aagcggtgta tggggacagt gaccctcaac caggccaggg gctcctttga catcagttgt      540

gataaggata acaagagatt tgccctgctg ggtgatttct tccggaaatc taaagagaag      600

attggcaaag agtttaaaag aattgtccag agaatcaagg attttttgcg gaatcttgta      660

cccaggacag agtcctagtg tgtgccctac cctggctcag gcttctgggc tctgagaaat      720

aaactatgag agcaatttcc tcaggaaaaa aaaaaaaa                              758


<210>  550
<211>  173
<212>  PRT
<213>  Homo Sapiens

<400>  550

Met Gly Thr Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp 
1               5                   10                  15      


Ser Leu Val Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile 
            20                  25                  30          


Ala Gln Val Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly 
        35                  40                  45              


Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu 
    50                  55                  60                  


Asp Pro Arg Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val 
65                  70                  75                  80  


Ser Phe Thr Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser 
                85                  90                  95      


Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met 
            100                 105                 110         


Gly Thr Val Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys 
        115                 120                 125             


Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys 
    130                 135                 140                 


Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile 
145                 150                 155                 160 


Lys Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
                165                 170             


<210>  551
<211>  3487
<212>  DNA
<213>  Homo Sapiens

<400>  551
cccctagggg cccctgggac gaggaggaag cgccaggtcc ttcccgccgc cgccgccgcc       60

gccgccgcct gctcccctgg cacgcgcccc gccgccctcg gcagccgcag ctccgtgtcc      120

cctgagaacc agccgtcccg cgccatgggc acgcgtctgc cgctcgtcct gcgccagctc      180

cgccgcccgc cccagccccc gggccctccg cgccgcctcc gtgtgccctg tcgcgctagc      240

agcggcggcg gcggaggcgg cggcggtggc cgggagggcc tgcttggaca gcggcggccg      300

caggatggcc aggcccggag cagctgcagc cccggcggcc gaacgcccgc ggcgcgggac      360

tccatcgtca gagaagtcat tcagaattca aaagaagttc taagtttatt gcaagaaaaa      420

aaccctgcct tcaagccggt tcttgcaatt atccaggcag gtgacgacaa cttgatgcag      480

gaaatcaacc agaatttggc tgaggaggct ggtctgaaca tcactcacat ttgcctccct      540

ccagatagca gtgaagccga gattatagat gaaatcttaa agatcaatga agataccaga      600

gtacatggcc ttgcccttca gatctctgag aacttgttta gcaacaaagt cctcaatgcc      660

ttgaaaccag aaaaagatgt ggatggagta acagacataa acctggggaa gctggtgcga      720

ggggatgccc atgaatgttt tgtttcacct gttgccaaag ctgtaattga acttcttgaa      780

aaatcaggtg tcaacctaga tggaaagaag attttggtag tgggggccca tgggtctttg      840

gaagctgctc tacaatgcct gttccagaga aaagggtcca tgacaatgag catccagtgg      900

aaaacacgcc agcttcaaag caagcttcac gaggctgaca ttgtggtcct aggctcacct      960

aagccagaag agattcccct tacttggata caaccaggaa ctactgttct caactgctcc     1020

catgacttcc tgtcagggaa ggttgggtgt ggctctccaa gaatacattt tggtggactc     1080

attgaggaag atgatgtgat tctccttgct gcagctctgc gaattcagaa catggtcagt     1140

agtggaagga gatggcttcg tgaacagcag cacaggcggt ggagacttca ctgcttgaaa     1200

cttcagcctc tctcccctgt gccaagtgac attgagattt caagaggaca aactccaaaa     1260

gctgtggatg tccttgccaa ggagattgga ttgcttgcag atgaaattga aatctatggc     1320

aaaagcaaag ccaaagtacg tttgtccgtg ctagaaaggt taaaggatca agcagatgga     1380

aaatacgtct tagttgctgg gatcacaccc acccctcttg gagaagggaa gagcacagtc     1440

accatcgggc ttgtgcaggc tctgaccgca cacctgaatg tcaactcctt tgcctgcttg     1500

aggcagcctt cccaaggacc gacgtttgga gtgaaaggag gagccgcggg tggtggatat     1560

gcccaggtca tccccatgga ggagttcaac cttcacttga ctggagacat ccacgccatc     1620

accgctgcca ataacttgct ggctgccgcc atcgacacga ggattcttca tgaaaacacg     1680

caaacagata aggctctgta taatcggctg gttcctttag tgaatggtgt cagagaattt     1740

tcagaaattc agcttgctcg gctaaaaaaa ctgggaataa ataagactga tccgagcaca     1800

ctgacagaag aggaagtgag taaatttgcc cgtctcgaca tcgacccatc taccatcacg     1860

tggcagagag tattggatac aaatgaccga tttctacgaa aaataaccat cgggcaggga     1920

aacacagaga agggccatta ccggcaggcg cagtttgaca tcgcagtggc cagcgagatc     1980

atggcggtgc tggccctgac ggacagcctc gcagacatga aggcacggct gggaaggatg     2040

gtggtggcca gtgacaaaag cgggcagcct gtgacagcag atgatttggg ggtgacaggt     2100

gctttgacag ttttgatgaa agatgcaata aaaccaaacc tgatgcagac cctggaaggg     2160

acacctgtgt tcgtgcatgc gggccctttt gctaacattg ctcacggcaa ctcttcagtg     2220

ttggctgata aaattgccct gaaactggtt ggtgaagaag gatttgtagt gaccgaagct     2280

ggctttggtg ctgacatcgg aatggagaaa ttcttcaaca tcaagtgccg agcttccggc     2340

ttggtgccca acgtggttgt gttagtggca acggtgcgag ctctgaagat gcatggaggc     2400

gggccaagtg taacggctgg tgttcctctt aagaaagaat atacagagga gaacatccag     2460

ctggtggcag acggctgctg taacctccag aagcaaattc agatcactca gctctttggg     2520

gttcccgttg tggtggctct gaatgtcttc aagaccgaca cccgcgctga gattgacttg     2580

gtgtgtgagc ttgcaaagcg ggctggtgcc tttgatgcag tcccctgcta tcactggtcc     2640

gttggtggaa aaggatcggt ggacttggct cgggctgtga gagaggctgc gagtaaaaga     2700

agccgattcc agttcctgta tgatgttcag gttccaattg tggacaagat aaggaccatt     2760

gctcaggctg tctatggagc caaagatatt gaactctctc ctgaggcaca agccaaaata     2820

gatcgttaca ctcaacaggg ttttggaaat ttgcccatct gcatggcaaa gacccacctt     2880

tctctatctc accaacctga caaaaaaggt gtgccaaggg acttcatctt acctatcagt     2940

gacgtccggg ccagcatagg cgctgggttc atttaccctt tggtcggaac gatgagcacc     3000

atgccaggac tgcccacccg gccctgcttt tatgacatag atcttgatac cgaaacagaa     3060

caagttaaag gcttgttcta agtggacaag gctctcacag gacccgatgc agactcctga     3120

aacagactac tctttgcctt tttgctgcag ttggagaaga aactgaattt gaaaaatgtc     3180

tgttatgcaa tgctggagac atggtgaaat aggccaaaga tttcttcttc gttcaagatg     3240

aattctgttc acagtggagt atggtgttcg gcaaaaggac ctccaccaag actgaaagaa     3300

actaatttat ttctgtttct gtggagtttc cattatttct actgcttaca ctttagaatg     3360

tttattttat ggggactaag ggattaggag tgtgaactaa aaggtaacat tttccactct     3420

caagttttct actttgtctt tgaactgaaa ataaacatgg atctagaaaa ccaaaaaaaa     3480

aaaaaaa                                                               3487


<210>  552
<211>  978
<212>  PRT
<213>  Homo Sapiens

<400>  552

Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser Pro 
            260                 265                 270         


Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr Val 
        275                 280                 285             


Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly Ser 
    290                 295                 300                 


Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile Leu 
305                 310                 315                 320 


Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg Arg 
                325                 330                 335     


Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu Lys 
            340                 345                 350         


Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg Gly 
        355                 360                 365             


Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu Leu 
    370                 375                 380                 


Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg Leu 
385                 390                 395                 400 


Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val Leu 
                405                 410                 415     


Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr Val 
            420                 425                 430         


Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn Ser 
        435                 440                 445             


Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val Lys 
    450                 455                 460                 


Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu Glu 
465                 470                 475                 480 


Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala Asn 
                485                 490                 495     


Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn Thr 
            500                 505                 510         


Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn Gly 
        515                 520                 525             


Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu Gly 
    530                 535                 540                 


Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser Lys 
545                 550                 555                 560 


Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg Val 
                565                 570                 575     


Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln Gly 
            580                 585                 590         


Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala Val 
        595                 600                 605             


Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp 
    610                 615                 620                 


Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly 
625                 630                 635                 640 


Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val 
                645                 650                 655     


Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly 
            660                 665                 670         


Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly 
        675                 680                 685             


Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu 
    690                 695                 700                 


Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met 
705                 710                 715                 720 


Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn 
                725                 730                 735     


Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly 
            740                 745                 750         


Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu 
        755                 760                 765             


Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln 
    770                 775                 780                 


Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn 
785                 790                 795                 800 


Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu 
                805                 810                 815     


Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser 
            820                 825                 830         


Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala 
        835                 840                 845             


Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro 
    850                 855                 860                 


Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys 
865                 870                 875                 880 


Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr 
                885                 890                 895     


Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu 
            900                 905                 910         


Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile 
        915                 920                 925             


Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr 
    930                 935                 940                 


Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro 
945                 950                 955                 960 


Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly 
                965                 970                 975     


Leu Phe 
        


<210>  553
<211>  5035
<212>  DNA
<213>  Homo Sapiens

<400>  553
agtgcgcggt cgctccgcgc ctgcgcagga gaggtggtag gctcgggtgg ctggctccgg       60

ggagatagcg cctgtcagtc ggtgggtcgg tcctcgcgcc ggccctcccc ctccccggtc      120

tccgggggag gcgcggtgga gtccgccccc ggggttctcc gatgggggag aagcggcgac      180

ggcggcagtg gagtaaccga gccggagcgt gagcggcccc ggtgccccgt tccccacgga      240

ggccatgggc gacccagccc ccgcccgcag cctggacgac atcgacctgt ccgccctgcg      300

ggaccctgct gggatctttg agcttgtgga ggtggtcggc aatggaacct acggacaggt      360

gtacaagggt cggcatgtca agacggggca gctggctgcc atcaaggtca tggatgtcac      420

ggaggacgag gaggaagaga tcaaacagga gatcaacatg ctgaaaaagt actctcacca      480

ccgcaacatc gccacctact acggagcctt catcaagaag agccccccgg gaaacgatga      540

ccagctctgg ctggtgatgg agttctgtgg tgctggttca gtgactgacc tggtaaagaa      600

cacaaaaggc aacgccctga aggaggactg tatcgcctat atctgcaggg agatcctcag      660

gggtctggcc catctccatg cccacaaggt gatccatcga gacatcaagg ggcagaatgt      720

gctgctgaca gagaatgctg aggtcaagct agtggatttt ggggtgagtg ctcagctgga      780

ccgcaccgtg ggcagacgga acactttcat tgggactccc tactggatgg ctccagaggt      840

catcgcctgt gatgagaacc ctgatgccac ctatgattac aggagtgata tttggtctct      900

aggaatcaca gccatcgaga tggcagaggg agccccccct ctgtgtgaca tgcaccccat      960

gcgagccctc ttcctcattc ctcggaaccc tccgcccagg ctcaagtcca agaagtggtc     1020

taagaagttc attgacttca ttgacacatg tctcatcaag acttacctga gccgcccacc     1080

cacggagcag ctactgaagt ttcccttcat ccgggaccag cccacggagc ggcaggtccg     1140

catccagctt aaggaccaca ttgaccgatc ccggaagaag cggggtgaga aagaggagac     1200

agaatatgag tacagcggca gcgaggagga agatgacagc catggagagg aaggagagcc     1260

aagctccatc atgaacgtgc ctggagagtc gactctacgc cgggagtttc tccggctcca     1320

gcaggaaaat aagagcaact cagaggcttt aaaacagcag cagcagctgc agcagcagca     1380

gcagcgagac cccgaggcac acatcaaaca cctgctgcac cagcggcagc ggcgcataga     1440

ggagcagaag gaggagcggc gccgcgtgga ggagcaacag cggcgggagc gggagcagcg     1500

gaagctgcag gagaaggagc agcagcggcg gctggaggac atgcaggctc tgcggcggga     1560

ggaggagcgg cggcaggcgg agcgcgagca ggaatacaag cggaagcagc tggaggagca     1620

gcggcagtca gaacgtctcc agaggcagct gcagcaggag catgcctacc tcaagtccct     1680

gcagcagcag caacagcagc agcagcttca gaaacagcag cagcagcagc tcctgcctgg     1740

ggacaggaag cccctgtacc attatggtcg gggcatgaat cccgctgaca aaccagcctg     1800

ggcccgagag gtagaagaga gaacaaggat gaacaagcag cagaactctc ccttggccaa     1860

gagcaagcca ggcagcacgg ggcctgagcc ccccatcccc caggcctccc cagggccccc     1920

aggacccctt tcccagactc ctcctatgca gaggccggtg gagccccagg agggaccgca     1980

caagagcctg gtggcacacc gggtcccact gaagccatat gcagcacctg taccccgatc     2040

ccagtccctg caggaccagc ccacccgaaa cctggctgcc ttcccagcct cccatgaccc     2100

cgaccctgcc atccccgcac ccactgccac gcccagtgcc cgaggagctg tcatccgcca     2160

gaattcagac cccacctctg aaggacctgg ccccagcccg aatcccccag cctgggtccg     2220

cccagataac gaggccccac ccaaggtgcc tcagaggacc tcatctatcg ccactgccct     2280

taacaccagt ggggccggag ggtcccggcc agcccaggca gtccgtgcca gacctcgcag     2340

caactccgcc tggcaaatct atctgcaaag gcgggcagag cggggcaccc caaagcctcc     2400

agggccccct gctcagcccc ctggcccgcc caacgcctct agtaaccccg acctcaggag     2460

gagcgaccct ggctgggaac gctcggacag cgtccttcca gcctctcacg ggcacctccc     2520

ccaggctggc tcactggagc ggaaccgcgt gggagtctcc tccaaaccgg acagctcccc     2580

tgtgctctcc cctgggaata aagccaagcc cgacgaccac cgctcacggc caggccggcc     2640

cgcagacttt gtgttgctga aagagcggac tctggacgag gcccctcggc ctcccaagaa     2700

ggccatggac tactcgtcgt ccagcgagga ggtggaaagc agtgaggacg acgaggagga     2760

aggcgaaggc gggccagcag aggggagcag agatacccct gggggccgca gcgatgggga     2820

tacagacagc gtcagcacca tggtggtcca cgacgtcgag gagatcaccg ggacccagcc     2880

cccatacggg ggcggcacca tggtggtcca gcgcacccct gaagaggagc ggaacctgct     2940

gcatgctgac agcaatgggt acacaaacct gcctgacgtg gtccagccca gccactcacc     3000

caccgagaac agcaaaggcc aaagcccacc ctcgaaggat gggagtggtg actaccagtc     3060

tcgtgggctg gtaaaggccc ctggcaagag ctcgttcacg atgtttgtgg atctagggat     3120

ctaccagcct ggaggcagtg gggacagcat ccccatcaca gccctagtgg gtggagaggg     3180

cactcggctc gaccagctgc agtacgacgt gaggaagggt tctgtggtca acgtgaatcc     3240

caccaacacc cgggcccaca gtgagacccc tgagatccgg aagtacaaga agcgattcaa     3300

ctccgagatc ctctgtgcag ccctttgggg ggtcaacctg ctggtgggca cggagaacgg     3360

gctgatgttg ctggaccgaa gtgggcaggg caaggtgtat ggactcattg ggcggcgacg     3420

cttccagcag atggatgtgc tggaggggct caacctgctc atcaccatct cagggaaaag     3480

gaacaaactg cgggtgtatt acctgtcctg gctccggaac aagattctgc acaatgaccc     3540

agaagtggag aagaagcagg gctggaccac cgtgggggac atggagggct gcgggcacta     3600

ccgtgttgtg aaatacgagc ggattaagtt cctggtcatc gccctcaaga gctccgtgga     3660

ggtgtatgcc tgggccccca aaccctacca caaattcatg gccttcaagt cctttgccga     3720

cctcccccac cgccctctgc tggtcgacct gacagtagag gaggggcagc ggctcaaggt     3780

catctatggc tccagtgctg gcttccatgc tgtggatgtc gactcgggga acagctatga     3840

catctacatc cctgtgcaca tccagagcca gatcacgccc catgccatca tcttcctccc     3900

caacaccgac ggcatggaga tgctgctgtg ctacgaggac gagggtgtct acgtcaacac     3960

gtacgggcgc atcattaagg atgtggtgct gcagtggggg gagatgccta cttctgtggc     4020

ctacatctgc tccaaccaga taatgggctg gggtgagaaa gccattgaga tccgctctgt     4080

ggagacgggc cacctcgacg gggtcttcat gcacaaacga gctcagaggc tcaagttcct     4140

gtgtgagcgg aatgacaagg tgttttttgc ctcagtccgc tctgggggca gcagccaagt     4200

ttacttcatg actctgaacc gtaactgcat catgaactgg tgacggggcc ctgggctggg     4260

gctgtcccac actggaccca gctctccccc tgcagccagg cttcccgggc cgcccctctt     4320

tcccctccct gggcttttgc ttttactggt ttgatttcac tggagcctgc tgggaacgtg     4380

acctctgacc cctgatgctt tcgtgatcac gtgaccatcc tcttccccaa catgtcctct     4440

tcccaaaact gtgcctgtcc ccagcttctg gggagggaca cagcttcccc ttcccaggaa     4500

ttgagtgggc ctagcccctc cccccttttc tccatttgag aggagagtgc ttggggcttg     4560

aaccccttac cccactgctg ctgactgggc agggccctgg acccctttat ttgcacgtca     4620

ggggagccgg ctcccccctt gaatgtacca gaccctgggg ggggtcactg ggccctagat     4680

ttttgggggg tcaccagcca ctccaggggc agggaccatt tcttcatttt ctgaaagcac     4740

tttaatgatt ccccttcccc caaactccag ggaatggagg ggggaccccg ccagccaaaa     4800

cattcccccc attcccgacc cccctctcct cttctagccc atgcccttcc ccggtggagg     4860

gagggagcag ggagccctca ctctccacgc cccttgcttg catctgtata tagtgtgagc     4920

agcaagtaac ccttctccct ccccccccac ccctcctcaa tgtagtggcc ttggatatcc     4980

tgtttgttaa taaagacaat tcaaccagct cccaccaaaa aaaaaaaaaa aaaaa          5035


<210>  554
<211>  1332
<212>  PRT
<213>  Homo Sapiens

<400>  554

Met Gly Asp Pro Ala Pro Ala Arg Ser Leu Asp Asp Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Val Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Ser Pro Pro Gly 
                85                  90                  95      


Asn Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Val Lys Asn Thr Lys Gly Asn Ala Leu Lys Glu Asp 
        115                 120                 125             


Cys Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ala His Leu 
    130                 135                 140                 


His Ala His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Tyr Arg Ser Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Pro Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Ile Asp Phe Ile Asp Thr Cys Leu Ile Lys 
            260                 265                 270         


Thr Tyr Leu Ser Arg Pro Pro Thr Glu Gln Leu Leu Lys Phe Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Thr Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Ser Arg Lys Lys Arg Gly Glu Lys Glu Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Asp Asp Ser His Gly Glu Glu 
                325                 330                 335     


Gly Glu Pro Ser Ser Ile Met Asn Val Pro Gly Glu Ser Thr Leu Arg 
            340                 345                 350         


Arg Glu Phe Leu Arg Leu Gln Gln Glu Asn Lys Ser Asn Ser Glu Ala 
        355                 360                 365             


Leu Lys Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Arg Asp Pro Glu 
    370                 375                 380                 


Ala His Ile Lys His Leu Leu His Gln Arg Gln Arg Arg Ile Glu Glu 
385                 390                 395                 400 


Gln Lys Glu Glu Arg Arg Arg Val Glu Glu Gln Gln Arg Arg Glu Arg 
                405                 410                 415     


Glu Gln Arg Lys Leu Gln Glu Lys Glu Gln Gln Arg Arg Leu Glu Asp 
            420                 425                 430         


Met Gln Ala Leu Arg Arg Glu Glu Glu Arg Arg Gln Ala Glu Arg Glu 
        435                 440                 445             


Gln Glu Tyr Lys Arg Lys Gln Leu Glu Glu Gln Arg Gln Ser Glu Arg 
    450                 455                 460                 


Leu Gln Arg Gln Leu Gln Gln Glu His Ala Tyr Leu Lys Ser Leu Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln Gln Leu Gln Lys Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Leu Pro Gly Asp Arg Lys Pro Leu Tyr His Tyr Gly Arg Gly Met Asn 
            500                 505                 510         


Pro Ala Asp Lys Pro Ala Trp Ala Arg Glu Val Glu Glu Arg Thr Arg 
        515                 520                 525             


Met Asn Lys Gln Gln Asn Ser Pro Leu Ala Lys Ser Lys Pro Gly Ser 
    530                 535                 540                 


Thr Gly Pro Glu Pro Pro Ile Pro Gln Ala Ser Pro Gly Pro Pro Gly 
545                 550                 555                 560 


Pro Leu Ser Gln Thr Pro Pro Met Gln Arg Pro Val Glu Pro Gln Glu 
                565                 570                 575     


Gly Pro His Lys Ser Leu Val Ala His Arg Val Pro Leu Lys Pro Tyr 
            580                 585                 590         


Ala Ala Pro Val Pro Arg Ser Gln Ser Leu Gln Asp Gln Pro Thr Arg 
        595                 600                 605             


Asn Leu Ala Ala Phe Pro Ala Ser His Asp Pro Asp Pro Ala Ile Pro 
    610                 615                 620                 


Ala Pro Thr Ala Thr Pro Ser Ala Arg Gly Ala Val Ile Arg Gln Asn 
625                 630                 635                 640 


Ser Asp Pro Thr Ser Glu Gly Pro Gly Pro Ser Pro Asn Pro Pro Ala 
                645                 650                 655     


Trp Val Arg Pro Asp Asn Glu Ala Pro Pro Lys Val Pro Gln Arg Thr 
            660                 665                 670         


Ser Ser Ile Ala Thr Ala Leu Asn Thr Ser Gly Ala Gly Gly Ser Arg 
        675                 680                 685             


Pro Ala Gln Ala Val Arg Ala Arg Pro Arg Ser Asn Ser Ala Trp Gln 
    690                 695                 700                 


Ile Tyr Leu Gln Arg Arg Ala Glu Arg Gly Thr Pro Lys Pro Pro Gly 
705                 710                 715                 720 


Pro Pro Ala Gln Pro Pro Gly Pro Pro Asn Ala Ser Ser Asn Pro Asp 
                725                 730                 735     


Leu Arg Arg Ser Asp Pro Gly Trp Glu Arg Ser Asp Ser Val Leu Pro 
            740                 745                 750         


Ala Ser His Gly His Leu Pro Gln Ala Gly Ser Leu Glu Arg Asn Arg 
        755                 760                 765             


Val Gly Val Ser Ser Lys Pro Asp Ser Ser Pro Val Leu Ser Pro Gly 
    770                 775                 780                 


Asn Lys Ala Lys Pro Asp Asp His Arg Ser Arg Pro Gly Arg Pro Ala 
785                 790                 795                 800 


Asp Phe Val Leu Leu Lys Glu Arg Thr Leu Asp Glu Ala Pro Arg Pro 
                805                 810                 815     


Pro Lys Lys Ala Met Asp Tyr Ser Ser Ser Ser Glu Glu Val Glu Ser 
            820                 825                 830         


Ser Glu Asp Asp Glu Glu Glu Gly Glu Gly Gly Pro Ala Glu Gly Ser 
        835                 840                 845             


Arg Asp Thr Pro Gly Gly Arg Ser Asp Gly Asp Thr Asp Ser Val Ser 
    850                 855                 860                 


Thr Met Val Val His Asp Val Glu Glu Ile Thr Gly Thr Gln Pro Pro 
865                 870                 875                 880 


Tyr Gly Gly Gly Thr Met Val Val Gln Arg Thr Pro Glu Glu Glu Arg 
                885                 890                 895     


Asn Leu Leu His Ala Asp Ser Asn Gly Tyr Thr Asn Leu Pro Asp Val 
            900                 905                 910         


Val Gln Pro Ser His Ser Pro Thr Glu Asn Ser Lys Gly Gln Ser Pro 
        915                 920                 925             


Pro Ser Lys Asp Gly Ser Gly Asp Tyr Gln Ser Arg Gly Leu Val Lys 
    930                 935                 940                 


Ala Pro Gly Lys Ser Ser Phe Thr Met Phe Val Asp Leu Gly Ile Tyr 
945                 950                 955                 960 


Gln Pro Gly Gly Ser Gly Asp Ser Ile Pro Ile Thr Ala Leu Val Gly 
                965                 970                 975     


Gly Glu Gly Thr Arg Leu Asp Gln Leu Gln Tyr Asp Val Arg Lys Gly 
            980                 985                 990         


Ser Val Val Asn Val Asn Pro Thr  Asn Thr Arg Ala His  Ser Glu Thr 
        995                 1000                 1005             


Pro Glu  Ile Arg Lys Tyr Lys  Lys Arg Phe Asn Ser  Glu Ile Leu 
    1010                 1015                 1020             


Cys Ala  Ala Leu Trp Gly Val  Asn Leu Leu Val Gly  Thr Glu Asn 
    1025                 1030                 1035             


Gly Leu  Met Leu Leu Asp Arg  Ser Gly Gln Gly Lys  Val Tyr Gly 
    1040                 1045                 1050             


Leu Ile  Gly Arg Arg Arg Phe  Gln Gln Met Asp Val  Leu Glu Gly 
    1055                 1060                 1065             


Leu Asn  Leu Leu Ile Thr Ile  Ser Gly Lys Arg Asn  Lys Leu Arg 
    1070                 1075                 1080             


Val Tyr  Tyr Leu Ser Trp Leu  Arg Asn Lys Ile Leu  His Asn Asp 
    1085                 1090                 1095             


Pro Glu  Val Glu Lys Lys Gln  Gly Trp Thr Thr Val  Gly Asp Met 
    1100                 1105                 1110             


Glu Gly  Cys Gly His Tyr Arg  Val Val Lys Tyr Glu  Arg Ile Lys 
    1115                 1120                 1125             


Phe Leu  Val Ile Ala Leu Lys  Ser Ser Val Glu Val  Tyr Ala Trp 
    1130                 1135                 1140             


Ala Pro  Lys Pro Tyr His Lys  Phe Met Ala Phe Lys  Ser Phe Ala 
    1145                 1150                 1155             


Asp Leu  Pro His Arg Pro Leu  Leu Val Asp Leu Thr  Val Glu Glu 
    1160                 1165                 1170             


Gly Gln  Arg Leu Lys Val Ile  Tyr Gly Ser Ser Ala  Gly Phe His 
    1175                 1180                 1185             


Ala Val  Asp Val Asp Ser Gly  Asn Ser Tyr Asp Ile  Tyr Ile Pro 
    1190                 1195                 1200             


Val His  Ile Gln Ser Gln Ile  Thr Pro His Ala Ile  Ile Phe Leu 
    1205                 1210                 1215             


Pro Asn  Thr Asp Gly Met Glu  Met Leu Leu Cys Tyr  Glu Asp Glu 
    1220                 1225                 1230             


Gly Val  Tyr Val Asn Thr Tyr  Gly Arg Ile Ile Lys  Asp Val Val 
    1235                 1240                 1245             


Leu Gln  Trp Gly Glu Met Pro  Thr Ser Val Ala Tyr  Ile Cys Ser 
    1250                 1255                 1260             


Asn Gln  Ile Met Gly Trp Gly  Glu Lys Ala Ile Glu  Ile Arg Ser 
    1265                 1270                 1275             


Val Glu  Thr Gly His Leu Asp  Gly Val Phe Met His  Lys Arg Ala 
    1280                 1285                 1290             


Gln Arg  Leu Lys Phe Leu Cys  Glu Arg Asn Asp Lys  Val Phe Phe 
    1295                 1300                 1305             


Ala Ser  Val Arg Ser Gly Gly  Ser Ser Gln Val Tyr  Phe Met Thr 
    1310                 1315                 1320             


Leu Asn  Arg Asn Cys Ile Met  Asn Trp 
    1325                 1330         


<210>  555
<211>  2724
<212>  DNA
<213>  Homo Sapiens

<400>  555
cccgcccctg gctagccgcg cccgcccccg cgctcctgct tcctcccctc tttccctccc       60

cgcctcccag gcgcgcaccc ctcccctcgc gcccctcccg cgccctacat ccaccgcccg      120

gcggaggggg ctcagtccgc agccgccgcc gccaccgccg cgcctcggcc tcggtgcagg      180

cagcggccgc cgccgccgag acagctgcgc gggcgagcat ccccacgcag caccttggaa      240

gttgttttca accatatcca gcctttgccg aatacatcct atctgccaca catccagcgt      300

gaggtccctc cagctacaag gtgggcacca tggcggagaa gtttgactgc cactactgca      360

gggatccctt gcaggggaag aagtatgtgc aaaaggatgg ccaccactgc tgcctgaaat      420

gctttgacaa gttctgtgcc aacacctgtg tggaatgccg caagcccatc ggtgcggact      480

ccaaggaggt gcactataag aaccgcttct ggcatgacac ctgcttccgc tgtgccaagt      540

gccttcaccc cttggccaat gagacctttg tggccaagga caacaagatc ctgtgcaaca      600

agtgcaccac tcgggaggac tcccccaagt gcaaggggtg cttcaaggcc attgtggcag      660

gagatcaaaa cgtggagtac aaggggaccg tctggcacaa agactgcttc acctgtagta      720

actgcaagca agtcatcggg actggaagct tcttccctaa aggggaggac ttctactgcg      780

tgacttgcca tgagaccaag tttgccaagc attgcgtgaa gtgcaacaag gccatcacat      840

ctggaggaat cacttaccag gatcagccct ggcatgccga ttgctttgtg tgtgttacct      900

gctctaagaa gctggctggg cagcgtttca ccgctgtgga ggaccagtat tactgcgtgg      960

attgctacaa gaactttgtg gccaagaagt gtgctggatg caagaacccc atcactggga     1020

aaaggactgt gtcaagagtg agccacccag tctctaaagc taggaagccc ccagtgtgcc     1080

acgggaaacg cttgcctctc accctgtttc ccagcgccaa cctccggggc aggcatccgg     1140

gtggagagag gacttgtccc tcgtgggtgg tggttcttta tagaaaaaat cgaagcttag     1200

cagctcctcg aggcccgggt ttggtaaagg ctccagtgtg gtggcctatg aaggacaatc     1260

ctggcacgac tactgcttcc actgcaaaaa atgctccgtg aatctggcca acaagcgctt     1320

tgttttccac caggagcaag tgtattgtcc cgactgtgcc aaaaagctgt aaactgacag     1380

gggctcctgt cctgtaaaat ggcatttgaa tctcgttctt tgtgtcctta ctttctgccc     1440

tataccatca ataggggaag agtggtcctt cccttcttta aagttctcct tccgtctttt     1500

ctcccatttt acagtattac tcaaataagg gcacacagtg atcatattag catttagcaa     1560

aaagcaaccc tgcagcaaag tgaatttctg tccggctgca atttaaaaat gaaaacttag     1620

gtagattgac tcttctgcat gtttctcata gagcagaaaa gtgctaatca tttagccact     1680

tagtgatgta agcaagaagc ataggagata aaacccccac tgagatgcct ctcatgcctc     1740

agctgggacc caccgtgtag acacacgaca tgcaagagtt gcagcggctg ctccaactca     1800

ctgctcaccc tcttctgtga gcaggaaaag aaccctactg acatgcatgg tttaacttcc     1860

tcatcagaac tctgcccttc cttctgttct tttgtgcttt caaataacta acacgaactt     1920

ccagaaaatt aacatttgaa cttagctgta attctaaact gacctttccc cgtactaacg     1980

tttggtttcc ccgtgtggca tgttttctga gcgttcctac tttaaagcat ggaacatgca     2040

ggtgatttgg gaagtgtaga aagacctgag aaaacgagcc tgtttcagag gaacatcgtc     2100

acaacgaata cttctggaag cttaacaaaa ctaaccctgc tgtccttttt attgttttta     2160

attaatattt ttgttttaat tgatagcaaa atagtttatg ggtttggaaa cttgcatgaa     2220

aatattttag ccccctcaga tgttcctgca gtgctgaaat tcatcctacg gaagtaaccg     2280

caaaactcta gagggggagt tgagcaggcg ccagggctgt catcaacatg gatatgacat     2340

ttcacaacag tgactagttg aatcccttgt aacgtagtag ttgtctgctc tttgtccatg     2400

tgttaatgag gactgcaaag tcccttctgt tgtgattcct aggacttttc ctcaagagga     2460

aatctggatt tccacctacc gcttacctga aatgcaggat cacctactta ctgtattcta     2520

cattattata tgacatagta taatgagaca atatcaaaag taaacatgta atgacaatac     2580

atactaacat tcttgtagga gtggttagag aagctgatgc ctcatttcta cattctgtca     2640

ttagctatta tcatctaacg tttcagtgta tccttacaga aataaagcag catatgaata     2700

acctgcaaaa aaaaaaaaaa aaaa                                            2724


<210>  556
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  556

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Lys Arg Thr Val Ser Arg Val Ser His Pro 
225                 230                 235                 240 


Val Ser Lys Ala Arg Lys Pro Pro Val Cys His Gly Lys Arg Leu Pro 
                245                 250                 255     


Leu Thr Leu Phe Pro Ser Ala Asn Leu Arg Gly Arg His Pro Gly Gly 
            260                 265                 270         


Glu Arg Thr Cys Pro Ser Trp Val Val Val Leu Tyr Arg Lys Asn Arg 
        275                 280                 285             


Ser Leu Ala Ala Pro Arg Gly Pro Gly Leu Val Lys Ala Pro Val Trp 
    290                 295                 300                 


Trp Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys 
305                 310                 315                 320 


Asn Ala Pro 
            


<210>  557
<211>  6402
<212>  DNA
<213>  Homo Sapiens

<400>  557
tgcgtcatca gggtgcgcca ctgcagctgg cattggccgg gactggaagt gcgggcttct       60

gcagcagccg aagctggagc tgctaggcag cggctcccct gttgtatgga cattctgcac      120

ccgaaactga tagctgagtc ctgaagtttt atgttatgaa acagaagaac tttcatccca      180

gcacatgatt tgggaattac actttgtgac atggatgaat ctgcactgac ccttggtaca      240

atagatgttt cttatctgcc acattcatca gaatacagtg ttggtcgatg taagcacaca      300

agtgaggaat ggggtgagtg tggctttaga cccaccatct tcagatctgc aactttaaaa      360

tggaaagaaa gcctaatgag tcggaaaagg ccatttgttg gaagatgttg ttactcctgc      420

actccccaga gctgggacaa atttttcaac cccagtatcc cgtctttggg tttgcggaat      480

gttatttata tcaatgaaac tcacacaaga caccgcggat ggcttgcaag acgcctttct      540

tacgttcttt ttattcaaga gcgagatgtg cataagggca tgtttgccac caatgtgact      600

gaaaatgtgc tgaacagcag tagagtacaa gaggcaattg cagaagtggc tgctgaatta      660

aaccctgatg gttctgccca gcagcaatca aaagccgtta acaaagtgaa aaagaaagct      720

aaaaggattc ttcaagaaat ggttgccact gtctcaccgg caatgatcag actgactggg      780

tgggtgctgc taaaactgtt caacagcttc ttttggaaca ttcaaattca caaaggtcaa      840

cttgagatgg ttaaagctgc aactgagacg aatttgccgc ttctgtttct accagttcat      900

agatcccata ttgactatct gctgctcact ttcattctct tctgccataa catcaaagca      960

ccatacattg cttcaggcaa taatctcaac atcccaatct tcagtacctt gatccataag     1020

cttgggggct tcttcatacg acgaaggctc gatgaaacac cagatggacg gaaagatgtt     1080

ctctatagag ctttgctcca tgggcatata gttgaattac ttcgacagca gcaattcttg     1140

gagatcttcc tggaaggcac acgttctagg agtggaaaaa cctcttgtgc tcgggcagga     1200

cttttgtcag ttgtggtaga tactctgtct accaatgtca tcccagacat cttgataata     1260

cctgttggaa tctcctatga tcgcattatc gaaggtcact acaatggtga acaactgggc     1320

aaacctaaga agaatgagag cctgtggagt gtagcaagag gtgttattag aatgttacga     1380

aaaaactatg gttgtgtccg agtggatttt gcacagccat tttccttaaa ggaatattta     1440

gaaagccaaa gtcagaaacc ggtgtctgct ctactttccc tggagcaagc gttgttacca     1500

gctatacttc cttcaagacc cagtgatgct gctgatgaag gtagagacac gtccattaat     1560

gagtccagaa atgcaacaga tgaatcccta cgaaggaggt tgattgcaaa tctggctgag     1620

catattctat tcactgctag caagtcctgt gccattatgt ccacacacat tgtggcttgc     1680

ctgctcctct acagacacag gcagggaatt gatctctcca cattggtcga agacttcttt     1740

gtgatgaaag aggaagtcct ggctcgtgat tttgacctgg ggttctcagg aaattcagaa     1800

gatgtagtaa tgcatgccat acagctgctg ggaaattgtg tcacaatcac ccacactagc     1860

aggaacgatg agttttttat cacccccagc acaactgtcc catcagtctt cgaactcaac     1920

ttctacagca atggggtact tcatgtcttt atcatggagg ccatcatagc ttgcagcctt     1980

tatgcagttc tgaacaagag gggactgggg ggtcccacta gcaccccacc taacctgatc     2040

agccaggagc agctggtgcg gaaggcggcc agcctgtgct accttctctc caatgaaggc     2100

accatctcac tgccttgcca gacattttac caagtctgcc atgaaacagt aggaaagttt     2160

atccagtatg gcattcttac agtggcagag cacgatgacc aggaagatat cagtcctagt     2220

cttgctgagc agcagtggga caagaagctt ccagaacctt tgtcttggag aagtgatgaa     2280

gaagatgaag acagtgactt tggggaggaa cagcgagatt gctacctgaa ggtgagccaa     2340

tccaaggagc accagcagtt tatcaccttc ttacagagac tccttgggcc tttgctggag     2400

gcctacagct ctgctgccat ctttgttcac aacttcagtg gtcctgttcc agaacctgag     2460

tatctgcaaa agttgcacaa atacctaata accagaacag aaagaaatgt tgcagtatat     2520

gctgagagtg ccacatattg tcttgtgaag aatgctgtga aaatgtttaa ggatattggg     2580

gttttcaagg agaccaaaca aaagagagtg tctgttttag aactgagcag cacttttcta     2640

cctcaatgca accgacaaaa acttctagaa tatattctga gttttgtggt gctgtaggta     2700

acgtgtggca ctgctggcaa atgaaggtca tgagatgagt tccttgtagg taccagcttc     2760

tggctcaaga gttgaaggtg ccatcgcagg gtcaggcctg ccctgtcccg aagtgatctc     2820

ctggaagaca agtgccttct ccctccatgg atctgtgatc ttcccagctc tgcatcaaca     2880

cagcagcctg cagataacac ttggggggac ctcagcctct attcgcaact cataatccgt     2940

agactacaag atgaaatctc aataaattat ttttgagttt attaaagatt gacattttaa     3000

gtacaacttt taaggactaa ttactgtgat ggacacagaa atgtagctgt gttctggaac     3060

tgaatcttac atggtatact tagtgctgct gggtaatttg ttggtatatt atctggttag     3120

tggttaatgc ttcctttaaa aataattgag tcatccattc actctttttc agttttatct     3180

gtcaatagta gctacatttt taatgggagc accttttatc ccaaagtgct ttataaattg     3240

agtggactga tatatatcac acccaggtat cactgtgctg tcctttgctg tcagatttag     3300

aaatgttttt aagagctatg tgaaaacaga caatattagt ttaggtcggg aactgagata     3360

ttgtaatcaa atagttaaca tcaggaagtt aatttggctg gcaaaattct agggaaactt     3420

ggccagaaaa ctggtgttga aggcttttgc tcatataaac aagtgccatt gagtttcaaa     3480

tgaccagcaa atatatttag aacccttcct gttttatgtc tgtacctcgt ccacccctca     3540

ggtaatacct gcctctcaca ggtacagctg tttcttggaa atcctccaac caaatagcag     3600

ttttcctaac ttgattagct tgagctgaca gactgttaga atacagttct ctggccacag     3660

ctgatgaggg ctttctgtac tgcacacaga ttgtgtactg caccccagtc caggtgactg     3720

gtacccactc gagttgtgcc gtgcacaacc tgtccagtat atgcatgtgg tggccctact     3780

gactggtaat ggttagaggc atttatggat ttttagcttt gaggaaaaac catgactttt     3840

aacaaatttt tatgggttat atgcctaaac ccttatgcca catagtggta aataattatg     3900

aaaaatggtc tgttcataat tggtaggtgc cttttgtgag cagggagcat aattattggt     3960

ttattatggt aattatggtg attttttaaa tatcatgtaa tgttaaaacg ttttctaaca     4020

gtttactgtt gcttatctcc aagatattat ggaattaaga atttttccag atgagtgtta     4080

catagattct ttgaatttag tataaaagta ctgagaatta agtttgtact tccataagct     4140

tggattttaa acactgatag tatctcatga gtaatgtgtg ttttgggaga gggagggatg     4200

ctgattgata tttcacattg tatgaaatac catgtttgaa actcatagca ataatgctat     4260

gctgttgtga tccctctcaa gttctgcatt taaaatatat tttttcttta taggaattga     4320

tgtataccat gaagtcattg tcagttgtag tagctctgat gttgaatgag atatcatgtt     4380

ttagcattcc attttactga ctagggtaga agaacacttt tcttggctac atttggagga     4440

tacccaggga gtcttgggtg ttccttatct ggggaagcaa acatttcact agtctctttt     4500

tttcatcctt taaattgtaa attaaggatt actcaagctc accattattc aagattggga     4560

ctcgcttccc agtcgacact ctgccctgcc tgtcattgct gcaaagagct gctgctttgc     4620

caacctaagc aaagaaaata cggcttctct tgcattattt tcccttttgg ttggtttgtt     4680

ttctagaagt acgttcagat gctttgggga atgcaatgta tgatttgcta gctctctcac     4740

cacttaactc actgtgagga taaatatgca tgctttttgt aattaactgg tgctttgaaa     4800

atctttttta agggagaaaa atctcaacca aagttatgct catccagaca agctgacctt     4860

tgagttaatt tcagcacaac tcattcttca gtgcctcatg actgaaaaca aaaaacaaaa     4920

aaacgaaagc atcttcacaa tgaagcttcc agatagcacc gttttgctaa aagatacatt     4980

ctcattgttt tccaacagtg atggcttcca cataaggtta aacaaactag gtgcttgtaa     5040

ataatttatt acagtttact ctatcgcatt tctgtaacat gaaatgcatg cccttcttca     5100

ggggaagact gtggtcaagt taaaaaaaaa aaacaatatt aaacaacatg aaactgcagt     5160

ctgtttttga aaatgagaat gtcctaagtg attcagaaga gaggagggaa gttgtgcact     5220

ctgaaaatgc atgaaaaaca aaggcaaaaa ctagtgggaa atgtgtagaa ctgttaactg     5280

agatggcttc gagtcttcct tctggaatct gttaaatttc acaaagtcat gagggtaaat     5340

ggagaaaata tttctgggat tacaatgaat gtaagcccaa attgtggaat tgccagtaac     5400

ctggatgggg aaaagcattt cccatagcac tccatgtaat atgagtgctc tgtgagatgt     5460

tcatcagtgt tttatagaaa tggtgttgct gggaaaccaa gtttgcacct ggaaacttac     5520

aatgcacttt agcgcagtaa gggcttggca tccggtagtg aaaaactgtc taacccagca     5580

ttgcccaaac tattttgaca ccaggacctt tttctccttt gggatactta tgaacctctc     5640

actaatgtcc tgtggagaac attttgggaa acactatgtt agatagttct ttaaggagac     5700

aaaacggtaa tgaacagata gcactggggc agaatatgca tgcattttgt aacgtccagt     5760

gtggcgttga atagatgtgt atttcctccc ctgcagaaaa taagcacaga aaattataat     5820

gtaggtgatc ggagctcttt cctttgatag agagaacagc cccaatgatc ctggcttttt     5880

cactgaacgt atcagaatac atggatgaat tggggtaaat aaggttttaa ttcagatcta     5940

gaagaaagta ttgtacgttt gaatgcagat ttttatccac agatagttgt agtgtttaga     6000

catgacagga cctatcgttg aggtttctaa gacttactat gggctgtaaa cctgtttttt     6060

aaaactattt tagaaacctg agacttgccg tctggcattt tagtttaata caaactaatg     6120

attgcatttg aaagagattc ttgaccttat ttctaaacgt ctagagctct gaaatgtctt     6180

gatggaaggt attaaactat ttgcctgttg tacaaagaaa tgttaagact cgtgaaaaga     6240

attactataa ggtactgtga aataactgcg attttgtgag caaaacatac ttggaaatgc     6300

tgattgattt ttatgcttgt tagtgtattg caagaaacac agaaaatgta gttttgtttt     6360

aataaaccaa aaattgaaca tacaaaaaaa aaaaaaaaaa aa                        6402


<210>  558
<211>  828
<212>  PRT
<213>  Homo Sapiens

<400>  558

Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu 
1               5                   10                  15      


Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu 
            20                  25                  30          


Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr 
        35                  40                  45              


Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
    50                  55                  60                  


Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn 
65                  70                  75                  80  


Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                85                  90                  95      


Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val 
            100                 105                 110         


Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn 
        115                 120                 125             


Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
    130                 135                 140                 


Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
145                 150                 155                 160 


Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu 
                165                 170                 175     


Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val 
            180                 185                 190         


Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
        195                 200                 205             


Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
    210                 215                 220                 


Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
225                 230                 235                 240 


Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                245                 250                 255     


Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
            260                 265                 270         


Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
        275                 280                 285             


Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
    290                 295                 300                 


Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
305                 310                 315                 320 


Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                325                 330                 335     


Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val 
            340                 345                 350         


Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
        355                 360                 365             


Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
    370                 375                 380                 


Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe 
385                 390                 395                 400 


Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys 
                405                 410                 415     


Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
            420                 425                 430         


Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser 
        435                 440                 445             


Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu 
    450                 455                 460                 


Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
465                 470                 475                 480 


Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                485                 490                 495     


Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
            500                 505                 510         


Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
        515                 520                 525             


Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
    530                 535                 540                 


Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser 
545                 550                 555                 560 


Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                565                 570                 575     


Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala 
            580                 585                 590         


Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn 
        595                 600                 605             


Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
    610                 615                 620                 


Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
625                 630                 635                 640 


Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                645                 650                 655     


Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala 
            660                 665                 670         


Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser 
        675                 680                 685             


Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
    690                 695                 700                 


Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe 
705                 710                 715                 720 


Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                725                 730                 735     


Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu 
            740                 745                 750         


Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala 
        755                 760                 765             


Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
    770                 775                 780                 


Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val 
785                 790                 795                 800 


Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln 
                805                 810                 815     


Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
            820                 825             


<210>  559
<211>  3126
<212>  DNA
<213>  Homo Sapiens

<400>  559
cgagctgctg cccgcaggag gcaggacgcg caggggtggg accggcgccc cagcccgtct       60

cccggccccg ggcgcgcggg aaccccgggt cctgcagcct cccgagtgcg gagaggcggg      120

gccgcccgct gccgcccggc tgcctgcgcc ccctcccgcg gccccggctc tgggagcggg      180

gcgccccgcg cgcgggcaca cggcggccag agcgccgagg cggtaccttc agcctgcaat      240

gagaggaacc cgggagagcc cccgggagcc agcgaagagc ttggctgctg cgtccagggc      300

tgctgctgcc gccgcggctg cttgaaactc ctcaaagttg agagccggct agagggtgcc      360

gcccgccggg agccggaggg aaaggaagtc ggaaggtgca agagtgacag acacggacag      420

acggacgcgc agaccttcgg aaggcactgc gtaggcagcc tccccggagc ccacgaggct      480

ccccagcacc gactaaccca ggaaagagga aaaaatacat ttaacagtga agaggcaaca      540

cagagctccc tattgtgaaa taaaacccat ttcaaaagtt attggaaaga aagttcactg      600

gtgggaggct gagccggtgg aaaagacacc gggaagagac tcagaggcga ccataatgtc      660

gttacgtgta cacactctgc ccaccctgct tggagccgtc gtcagaccgg gctgcaggga      720

gctgctgtgt ttgctgatga tcacagtgac tgtgggccct ggtgcctctg gggtgtgccc      780

caccgcttgc atctgtgcca ctgacatcgt cagctgcacc aacaaaaacc tgtccaaggt      840

gcctgggaac cttttcagac tgattaagag actggacctg agttataaca gaattgggct      900

tctggattct gagtggattc cagtatcgtt tgcaaagctg aacaccctaa ttcttcgtca      960

taacaacatc accagcattt ccacgggcag tttttccaca actccaaatt tgaagtgtct     1020

tgacttatcg tccaataagc tgaagacggt gaaaaatgct gtattccaag agttgaaggt     1080

tctggaagtg cttctgcttt acaacaatca catatcctat ctcgatcctt cagcgtttgg     1140

agggctctcc cagttgcaga aactctactt aagtggaaat tttctcacac agtttccgat     1200

ggatttgtat gttggaaggt tcaagctggc agaactgatg tttttagatg tttcttataa     1260

ccgaattcct tccatgccaa tgcaccacat aaatttagtg ccaggaaaac agctgagagg     1320

catctacctt catggaaacc catttgtctg tgactgttcc ctgtactcct tgctggtctt     1380

ttggtatcgt aggcacttta gctcagtgat ggattttaag aacgattaca cctgtcgcct     1440

gtggtctgac tccaggcact cgcgtcaggt acttctgctc caggatagct ttatgaattg     1500

ctctgacagc atcatcaatg gttcctttcg tgcgcttggc tttattcatg aggctcaggt     1560

cggggaaaga ctgatggtcc actgtgacag caagacaggt aatgcaaata cggatttcat     1620

ctgggtgggt ccagataaca gactgctaga gccggataaa gagatggaaa acttttacgt     1680

gtttcacaat ggaagtctgg ttatagaaag ccctcgtttt gaggatgctg gagtgtattc     1740

ttgtatcgca atgaataagc aacgcctgtt aaatgaaact gtggacgtca caataaatgt     1800

gagcaatttc actgtaagca gatcccatgc tcatgaggca tttaacacag cttttaccac     1860

tcttgctgct tgcgtggcca gtatcgtttt ggtacttttg tacctctatc tgactccatg     1920

cccctgcaag tgtaaaacca agagacagaa aaatatgcta caccaaagca atgcccattc     1980

atcgattctc agtcctggcc ccgctagtga tgcctccgct gatgaacgga aggcaggtgc     2040

aggtaaaaga gtggtgtttt tggaacccct gaaggatact gcagcagggc agaacgggaa     2100

agtcaggctc tttcccagcg aggcagtgat agctgagggc atcctaaagt ccacgagggg     2160

gaaatctgac tcagattcag tcaattcagt gttttctgac acaccttttg tggcgtccac     2220

ttaatttgtg cctatatttg tatgatgtca taatttaatc tgttcatatt taactttgtg     2280

tgtggtctgc aaaataaaca gcaggacaga aattgtgttg ttttgttctt tgaaatacaa     2340

ccaaattctc ttaaaatgat tggtaggaaa tgaggtaaag tacttcagtt cctcaatgtg     2400

ccatagaaag atggggttgt tttccaaagt ttaagttcta gatcacaata tcttagcttt     2460

tagcactatt ggtaatttca gagtaggccc aaaggtgata tgactcccat tgtcccttta     2520

tttaggatat tgaaagaaaa aataaacttt atgtattagt gtcctttaaa aatagacttt     2580

gctaacttac tagtaccaga gttattttaa agaaaaacac tagtgtccaa tttcattttt     2640

aaaagatgta gaaagaagaa tcaagcatca attaattata aagcctaaag caaagttaga     2700

tttgggggtt attcagccaa aattaccgtt ttagaccaga atgaatagac tacactgata     2760

aaatgtactg gataatgcca catcctatat ggtgttatag aaatagtgca aggaaagtac     2820

atttgtttgc ctgtcttttc attttgtaca ttcttcccat tctgtattct tgtacaaaag     2880

atctcattga aaatttaaag tcatcataat ttgttgccat aaatatgtaa gtgtcaatac     2940

caaaatgtct gagtaacttc ttaaatccct gttctagcaa actaatattg gttcatgtgc     3000

ttgtgtatat gtaaatctta aattatgtga actattaaat agaccctact gtactgtgaa     3060

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaaa                                                                3126


<210>  560
<211>  522
<212>  PRT
<213>  Homo Sapiens

<400>  560

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val 
1               5                   10                  15      


Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr 
            20                  25                  30          


Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala 
        35                  40                  45              


Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly 
    50                  55                  60                  


Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile 
65                  70                  75                  80  


Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn 
                85                  90                  95      


Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser 
            100                 105                 110         


Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys 
        115                 120                 125             


Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu 
    130                 135                 140                 


Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala 
145                 150                 155                 160 


Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe 
                165                 170                 175     


Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala 
            180                 185                 190         


Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro 
        195                 200                 205             


Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr 
    210                 215                 220                 


Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 
225                 230                 235                 240 


Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn 
                245                 250                 255     


Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val 
            260                 265                 270         


Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn 
        275                 280                 285             


Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu 
    290                 295                 300                 


Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 
305                 310                 315                 320 


Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu 
                325                 330                 335     


Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser 
            340                 345                 350         


Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys 
        355                 360                 365             


Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn 
    370                 375                 380                 


Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 
385                 390                 395                 400 


Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr 
                405                 410                 415     


Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys 
            420                 425                 430         


Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly 
        435                 440                 445             


Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys 
    450                 455                 460                 


Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn 
465                 470                 475                 480 


Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile 
                485                 490                 495     


Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val 
            500                 505                 510         


Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 
        515                 520         


<210>  561
<211>  1633
<212>  DNA
<213>  Homo Sapiens

<400>  561
attgtggtgc cttgtagctg tcccgggagc cctcagcagc agttggagct ggtgcacagg       60

aaggatgagg aagaccaggc tctgggggct gctgtggatg ctctttgtct cagaactccg      120

agctgcaact aaattaactg aggaaaagta tgaactgaaa gaggggcaga ccctggatgt      180

gaaatgtgac tacacgctag agaagtttgc cagcagccag aaagcttggc agataataag      240

ggacggagag atgcccaaga ccctggcatg cacagagagg ccttcaaaga attcccatcc      300

agtccaagtg gggaggatca tactagaaga ctaccatgat catggtttac tgcgcgtccg      360

aatggtcaac cttcaagtgg aagattctgg actgtatcag tgtgtgatct accagcctcc      420

caaggagcct cacatgctgt tcgatcgcat ccgcttggtg gtgaccaagg gtttttcagg      480

gacccctggc tccaatgaga attctaccca gaatgtgtat aagattcctc ctaccaccac      540

taaggccttg tgcccactct ataccagccc cagaactgtg acccaagctc cacccaagtc      600

aactgccgat gtctccactc ctgactctga aatcaacctt acaaatgtga cagatatcat      660

cagggttccg gtgttcaaca ttgtcattct cctggctggt ggattcctga gtaagagcct      720

ggtcttctct gtcctgtttg ctgtcacgct gaggtcattt gtaccctagg cccacgaacc      780

cacgagaatg tcctctgact tccagccaca tccatctggc agttgtgcca agggaggagg      840

gaggaggtaa aaggcaggga gttaataaca tgaattaaat ctgtaatcac cggctatttc      900

taaagtcagc gtctcacctt cctgcccact gccctcgttc ctctaataat cttgggtggg      960

catttgtgcc tcagaaaaga agttacagcc ccaaacatgc ttggtccttc attccaccag     1020

ccacttgggg ttggcatgaa atacagacag ctcaatgctt ttcaccgtaa ttctcttgtg     1080

ggggctgtga catgcagaag gcacacctga tacttctcct gctcagtttt gccctggacc     1140

atacaatttt ggcctgacct ggacagagct cccactacag aagcatcctg ctcgccccat     1200

gctgggactt cctctttcta gcatcagaca cttgggtttc atgcttatgt gtggttcttt     1260

ccaacactcc cagaaaaggg tgttgaagat tgtggaacct ggagaaataa gacatcgtgg     1320

tgagaaagtg catccttctc agagaaaaga gttaaactga gtatcttctt ctggggaaat     1380

actggcaggc cgagatggga tccataggag agcaacaaca gaccatgtca gacatcctgt     1440

gtgcatttat cgctggatcc tgaaaatagc cccgtgaagg cagaaatgta tgtgactaga     1500

acgaggccac atgaataagc cactgcccac tggcaggagt gaaaactgaa gcgctcctta     1560

cctgaaggac cccaaaacca tatagaatag aataaccagg agttccgcct gtgtctaaat     1620

gcctcttttc ctg                                                        1633


<210>  562
<211>  234
<212>  PRT
<213>  Homo Sapiens

<400>  562

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  563
<211>  1524
<212>  DNA
<213>  Homo Sapiens

<400>  563
aacagttgcc ttttcctctc acagaaggaa gatttcattt tgtttgagac gagaaaccaa       60

accacacacc aaagagaggg gtatgatggc taagaagccc ccaaaaccag cccctcgcag      120

gatcttccag gaaaggttaa agattactgc tctacctttg tactttgaag gttttttatt      180

aatcaagcgg tcaggatacc gggagtatga gcattactgg acagagttga gaggaactac      240

tcttttcttt tataccgaca aaaagagtat aatatatgtt gacaaattag acatagtaga      300

cctcacatgc cttactgagc agaattcaac tgaaaagaac tgtgcgaaat tcacccttgt      360

tttgccgaaa gaggaagtac aactgaagac agagaacaca gaaagtgggg aagaatggag      420

aggcttcatt cttacagtaa cagagctgtc agttccccaa aacgtgtcac tcctacctgg      480

gcaagtaatt aaactgcatg aagtcctaga gagagaaaag aaaaggagga ttgagacaga      540

gcagagtacg tccgtggaaa aagagaagga accaactgaa gattatgtgg atgtactgaa      600

ccctatgcca gcatgttttt atacagtgtc ccggaaagag gcaactgaga tgctccagaa      660

gaacccttct ttgggaaata tgatcctgag gcctggtagt gacagtagaa actactccat      720

cactattcgg caggagatag acattccaag aatcaagcac tacaaagtga tgagcgtagg      780

acaaaactac actattgaac tggaaaaacc tgtaacactc ccaaaccttt tcagtgtcat      840

tgattatttt gtgaaggaga ctcgaggaaa tttaagacca tttatatgtt caactgatga      900

aaacactggt caagaaccca gtatggaagg gagaagtgaa aagttgaaga aaaatccaca      960

cattgcatga aatacaatgt gaaagctcct ttgtatatct tggtaattta tattttcaaa     1020

acgaagttct tacttttaaa gagaattacc tatattctcc tgatactgat taccaagtca     1080

ttcacctgaa caccagaatt agaattaaac attgtaccat acaatttcat tatcttatca     1140

gaatgaaacc aattcacagg gaaactagag actacggctg tggtggtaac ctgcagatat     1200

acacattccc atgcactgac ataagttgaa aacacatagt actttctaga tggaattttt     1260

ttctttaggc ctcaatgaaa tacatttccc ctatataatt ccaacagcag tttctctagt     1320

tctaaatttt accaattccc aaaaaaccta agttttgctg aaatctgatt tgaccaattt     1380

atcaaatatg tcattttaat tacctagctg gaagttagag acatgaaatg tactagagga     1440

gcccttttcc aatggaaata ttatatacca cattttttgt taatggaaat aaatgtcttc     1500

attcccatgt taaaaaaaaa aaaa                                            1524


<210>  564
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  564

Met Met Ala Lys Lys Pro Pro Lys Pro Ala Pro Arg Arg Ile Phe Gln 
1               5                   10                  15      


Glu Arg Leu Lys Ile Thr Ala Leu Pro Leu Tyr Phe Glu Gly Phe Leu 
            20                  25                  30          


Leu Ile Lys Arg Ser Gly Tyr Arg Glu Tyr Glu His Tyr Trp Thr Glu 
        35                  40                  45              


Leu Arg Gly Thr Thr Leu Phe Phe Tyr Thr Asp Lys Lys Ser Ile Ile 
    50                  55                  60                  


Tyr Val Asp Lys Leu Asp Ile Val Asp Leu Thr Cys Leu Thr Glu Gln 
65                  70                  75                  80  


Asn Ser Thr Glu Lys Asn Cys Ala Lys Phe Thr Leu Val Leu Pro Lys 
                85                  90                  95      


Glu Glu Val Gln Leu Lys Thr Glu Asn Thr Glu Ser Gly Glu Glu Trp 
            100                 105                 110         


Arg Gly Phe Ile Leu Thr Val Thr Glu Leu Ser Val Pro Gln Asn Val 
        115                 120                 125             


Ser Leu Leu Pro Gly Gln Val Ile Lys Leu His Glu Val Leu Glu Arg 
    130                 135                 140                 


Glu Lys Lys Arg Arg Ile Glu Thr Glu Gln Ser Thr Ser Val Glu Lys 
145                 150                 155                 160 


Glu Lys Glu Pro Thr Glu Asp Tyr Val Asp Val Leu Asn Pro Met Pro 
                165                 170                 175     


Ala Cys Phe Tyr Thr Val Ser Arg Lys Glu Ala Thr Glu Met Leu Gln 
            180                 185                 190         


Lys Asn Pro Ser Leu Gly Asn Met Ile Leu Arg Pro Gly Ser Asp Ser 
        195                 200                 205             


Arg Asn Tyr Ser Ile Thr Ile Arg Gln Glu Ile Asp Ile Pro Arg Ile 
    210                 215                 220                 


Lys His Tyr Lys Val Met Ser Val Gly Gln Asn Tyr Thr Ile Glu Leu 
225                 230                 235                 240 


Glu Lys Pro Val Thr Leu Pro Asn Leu Phe Ser Val Ile Asp Tyr Phe 
                245                 250                 255     


Val Lys Glu Thr Arg Gly Asn Leu Arg Pro Phe Ile Cys Ser Thr Asp 
            260                 265                 270         


Glu Asn Thr Gly Gln Glu Pro Ser Met Glu Gly Arg Ser Glu Lys Leu 
        275                 280                 285             


Lys Lys Asn Pro His Ile Ala 
    290                 295 


<210>  565
<211>  3142
<212>  DNA
<213>  Homo Sapiens

<400>  565
agacactgaa tcatcatttg tagtttgggg ggctttacat gcctgcagtg gtgaaaactg       60

aaattttgtc ccacttaagg gagtttcttc ttccctttat taattgcaaa ataaatatat      120

gtcacttcag agggcagcag ctggactacc tatgtttgtg gcgctacacc aacctgaact      180

tcgcttcctg agacctaaga ttcagccccg tgctcagcag acatcaggga tcaccgactc      240

tgtgccagga gctgttcttg atgctgggaa cgcaggggtg gacaaaacag agaaagccct      300

gccctcagaa tgccagcagt tactctgcag agatgacgga gcccaagtcg gtgtgtgtct      360

cggtggatga ggtggtgtcc agcaacatgg aggccactga gacggacctg ctgaatggac      420

atctgaaaaa agtagataat aacctcacgg aagcccagcg cttctcctcc ttgcctcgga      480

gggcagctgt gaacattgaa ttcagggacc tttcctattc ggttcctgaa ggaccctggt      540

ggaggaagaa aggatacaag accctcctga aaggaatttc cgggaagttc aatagtggtg      600

agttggtggc cattatgggt ccttccgggg ccgggaagtc cacgctgatg aacatcctgg      660

ctggatacag ggagacgggc atgaaggggg ccgtcctcat caacggcctg ccccgggacc      720

tgcgctgctt ccggaaggtg tcctgctaca tcatgcagga tgacatgctg ctgccgcatc      780

tcactgtgca ggaggccatg atggtgtcgg cacatctgaa gcttcaggag aaggatgaag      840

gcagaaggga aatggtcaag gagatactga cagcgctggg cttgctgtct tgcgccaaca      900

cgcggaccgg gagcctgtca ggtggtcagc gcaagcgcct ggccatcgcg ctggagctgg      960

tgaacaaccc tccagtcatg ttcttcgatg agcccaccag cggcctggac agcgcctcct     1020

gcttccaggt ggtctcgctg atgaaagggc tcgctcaagg gggtcgctcc atcatttgca     1080

ccatccacca gcccagcgcc aaactcttcg agctgttcga ccagctttac gtcctgagtc     1140

aaggacaatg tgtgtaccgg ggaaaagtct gcaatcttgt gccatatttg agggatttgg     1200

gtctgaactg cccaacctac cacaacccag cagattttgt catggaggtt gcatccggcg     1260

agtacggtga tcagaacagt cggctggtga gagcggttcg ggagggcatg tgtgactcag     1320

accacaagag agacctcggg ggtgatgccg aggtgaaccc ttttctttgg caccggccct     1380

ctgaagagga ctcctcgtcc atggaaggct gccacagctt ctctgccagc tgcctcacgc     1440

agttctgcat cctcttcaag aggaccttcc tcagcatcat gagggactcg gtcctgacac     1500

acctgcgcat cacctcgcac attgggatcg gcctcctcat tggcctgctg tacttgggga     1560

tcgggaacga agccaagaag gtcttgagca actccggctt cctcttcttc tccatgctgt     1620

tcctcatgtt cgcggccctc atgcctactg ttctgacatt tcccctggag atgggagtct     1680

ttcttcggga acacctgaac tactggtaca gcctgaaggc ctactacctg gccaagacca     1740

tggcagacgt gccctttcag atcatgttcc cagtggccta ctgcagcatc gtgtactgga     1800

tgacgtcgca gccgtccgac gccgtgcgct ttgtgctgtt tgccgcgctg ggcaccatga     1860

cctccctggt ggcacagtcc ctgggcctgc tgatcggagc cgcctccacg tccctgcagg     1920

tggccacttt cgtgggccca gtgacagcca tcccggtgct cctgttctcg gggttcttcg     1980

tcagcttcga caccatcccc acgtacctac agtggatgtc ctacatctcc tatgtcaggt     2040

atgggttcga aggggtcatc ctctccatct atggcttaga ccgggaagat ctgcactgtg     2100

acatcgacga gacgtgccac ttccagaagt cggaggccat cctgcgggag ctggacgtgg     2160

aaaatgccaa gctgtacctg gacttcatcg tactcgggat tttcttcatc tccctccgcc     2220

tcattgccta ttttgtcctc aggtacaaaa tccgggcaga gaggtaaaac acctgaatgc     2280

caggaaacag gaagattaga cactgtggcc gagggcacgt ctagaatcga ggaggcaagc     2340

ctgtgcccga ccgacgacac agagactctt ctgatccaac ccctagaacc gcgttgggtt     2400

tgtgggtgtc tcgtgctcag ccactctgcc cagctgggtt ggatcttctc tccattcccc     2460

tttctagctt taactaggaa gatgtaggca gattggtggt tttttttttt ttaacataca     2520

gaattttaaa taccacaact ggggcagaat ttaaagctgc aacacagctg gtgatgagag     2580

gcttcctcag tccagtcgct ccttagcacc aggcaccgtg ggtcctggat ggggaactgc     2640

aagcagcctc tcagctgatg gctgcacagt cagatgtctg gtggcagaga gtccgagcat     2700

ggagcgattc cattttatga ctgttgtttt tcacattttc atctttctaa ggtgtgtctc     2760

ttttccaatg agaagtcatt tttgcaagcc aaaagtcgat caatcgcatt cattttaaga     2820

aattatacct ttttagtact tgctgaagaa tgattcaggg taaatcacat actttgttta     2880

gagaggcgag gggtttaacc gagtcaccca gctggtctca tacatagaca gcacttgtga     2940

aggattgaat gcaggttcca ggtggaggga agacgtggac accatctcca ctgagccatg     3000

cagacatttt taaaagctat acaaaaaatt gtgagaagac attggccaac tctttcaaag     3060

tctttctttt tccacgtgct tcttatttta agcgaaatat attgtttgtt tcttcctaaa     3120

aaaaaaaaaa aaaaaaaaaa aa                                              3142


<210>  566
<211>  668
<212>  PRT
<213>  Homo Sapiens

<400>  566

Met Leu Gly Thr Gln Gly Trp Thr Lys Gln Arg Lys Pro Cys Pro Gln 
1               5                   10                  15      


Asn Ala Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys 
            20                  25                  30          


Val Ser Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr 
        35                  40                  45              


Asp Leu Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu 
    50                  55                  60                  


Ala Gln Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu 
65                  70                  75                  80  


Phe Arg Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys 
                85                  90                  95      


Lys Gly Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser 
            100                 105                 110         


Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr 
        115                 120                 125             


Leu Met Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala 
    130                 135                 140                 


Val Leu Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val 
145                 150                 155                 160 


Ser Cys Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val 
                165                 170                 175     


Gln Glu Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp 
            180                 185                 190         


Glu Gly Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu 
        195                 200                 205             


Leu Ser Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg 
    210                 215                 220                 


Lys Arg Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met 
225                 230                 235                 240 


Phe Phe Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln 
                245                 250                 255     


Val Val Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile 
            260                 265                 270         


Cys Thr Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln 
        275                 280                 285             


Leu Tyr Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys 
    290                 295                 300                 


Asn Leu Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr 
305                 310                 315                 320 


His Asn Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly 
                325                 330                 335     


Asp Gln Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp 
            340                 345                 350         


Ser Asp His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe 
        355                 360                 365             


Leu Trp His Arg Pro Ser Glu Glu Asp Ser Ser Ser Met Glu Gly Cys 
    370                 375                 380                 


His Ser Phe Ser Ala Ser Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Ser Ile Met Arg Asp Ser Val Leu Thr His Leu Arg 
                405                 410                 415     


Ile Thr Ser His Ile Gly Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu 
            420                 425                 430         


Gly Ile Gly Asn Glu Ala Lys Lys Val Leu Ser Asn Ser Gly Phe Leu 
        435                 440                 445             


Phe Phe Ser Met Leu Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val 
    450                 455                 460                 


Leu Thr Phe Pro Leu Glu Met Gly Val Phe Leu Arg Glu His Leu Asn 
465                 470                 475                 480 


Tyr Trp Tyr Ser Leu Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp 
                485                 490                 495     


Val Pro Phe Gln Ile Met Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr 
            500                 505                 510         


Trp Met Thr Ser Gln Pro Ser Asp Ala Val Arg Phe Val Leu Phe Ala 
        515                 520                 525             


Ala Leu Gly Thr Met Thr Ser Leu Val Ala Gln Ser Leu Gly Leu Leu 
    530                 535                 540                 


Ile Gly Ala Ala Ser Thr Ser Leu Gln Val Ala Thr Phe Val Gly Pro 
545                 550                 555                 560 


Val Thr Ala Ile Pro Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe 
                565                 570                 575     


Asp Thr Ile Pro Thr Tyr Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val 
            580                 585                 590         


Arg Tyr Gly Phe Glu Gly Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg 
        595                 600                 605             


Glu Asp Leu His Cys Asp Ile Asp Glu Thr Cys His Phe Gln Lys Ser 
    610                 615                 620                 


Glu Ala Ile Leu Arg Glu Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu 
625                 630                 635                 640 


Asp Phe Ile Val Leu Gly Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala 
                645                 650                 655     


Tyr Phe Val Leu Arg Tyr Lys Ile Arg Ala Glu Arg 
            660                 665             


<210>  567
<211>  4573
<212>  DNA
<213>  Homo Sapiens

<400>  567
gcccgagaag ctggggagca tggaccagac cccgcagcgc tggcaccatg acgctcgccc       60

gcttcgtgct agccctgatg ttaggggcgc tccccgaagt ggtcggcttt gattctgtcc      120

tcaatgattc cctccaccac agccaccgcc attcgccccc tgcgggtccg cactacccct      180

attaccttcc cacccagcag cggcccccga ggacgcgtcc gccgccgcct ctcccgcgct      240

tcccgcgccc cccgcgggcg ctccctgccc agcgcccgca cgccctccag gccgggcaca      300

cgccccggcc gcacccctgg ggctgccccg ccggcgagcc atgggtcagc gtgacggact      360

tcggcgcccc gtgtctgcgg tgggcggagg tgccaccctt cctggagcgg tcgcccccag      420

cgagctgggc tcagctgcga ggacagcgcc acaacttttg tcggagcccc gacggcgcgg      480

gcagaccctg gtgtttctac ggagacgccc gtggcaaggt ggactggggc tactgcgact      540

gcagacacgg atcagtacga cttcgtggcg gcaaaaatga gtttgaaggc acagtggaag      600

tatatgcaag tggagtttgg ggcactgtct gtagcagcca ctgggatgat tctgatgcat      660

cagtcatttg tcaccagctg cagctgggag gaaaaggaat agcaaaacaa accccgtttt      720

ctggactggg ccttattccc atttattgga gcaatgtccg ttgccgagga gatgaagaaa      780

atatactgct ttgtgaaaaa gacatctggc agggtggggt gtgtcctcag aagatggcag      840

ctgctgtcac gtgtagcttt tcccatggcc caacgttccc catcattcgc cttgctggag      900

gcagcagtgt gcatgaaggc cgggtggagc tctaccatgc tggccagtgg ggaaccgttt      960

gtgatgacca atgggatgat gccgatgcag aagtgatctg caggcagctg ggcctcagtg     1020

gcattgccaa agcatggcat caggcatatt ttggggaagg gtctggccca gttatgttgg     1080

atgaagtacg ctgcactggg aatgagcttt caattgagca gtgtccaaag agctcctggg     1140

gagagcataa ctgtggccat aaagaagatg ctggagtgtc ctgtacccct ctaacagatg     1200

gggtcatcag acttgcaggt gggaaaggca gccatgaggg tcgcttggag gtatattaca     1260

gaggccagtg gggaactgtc tgtgatgatg gctggactga gctgaataca tacgtggttt     1320

gtcgacaatt gggatttaaa tatggtaaac aagcatctgc caaccatttt gaagaaagca     1380

cagggcccat atggttggat gacgtcagct gctcaggaaa ggaaaccaga tttcttcagt     1440

gttccaggcg acagtgggga aggcatgact gcagccaccg cgaagatgtt agcattgcct     1500

gctaccctgg cggcgaggga cacaggctct ctctgggttt tcctgtcaga ctgatggatg     1560

gagaaaataa gaaagaagga cgagtggagg tttttatcaa tggccagtgg ggaacaatct     1620

gtgatgatgg atggactgat aaggatgcag ctgtgatctg tcgtcagctt ggctacaagg     1680

gtcctgccag agcaagaacc atggcttact ttggagaagg aaaaggaccc atccatgtgg     1740

ataatgtgaa gtgcacagga aatgagaggt ccttggctga ctgtatcaag caagatattg     1800

gaagacacaa ctgccgccac agtgaagatg caggagttat ttgtgattat tttggcaaga     1860

aggcctcagg taacagtaat aaagagtccc tctcatctgt ttgtggcttg agattactgc     1920

accgtcggca gaagcggatc attggtggga aaaattcttt aaggggtggt tggccttggc     1980

aggtttccct ccggctgaag tcatcccatg gagatggcag gctcctctgc ggggctacgc     2040

tcctgagtag ctgctgggtc ctcacagcag cacactgttt caagaggtat ggcaacagca     2100

ctaggagcta tgctgttagg gttggagatt atcatactct ggtaccagag gagtttgagg     2160

aagaaattgg agttcaacag attgtgattc atcgggagta tcgacccgac cgcagtgatt     2220

atgacatagc cctggttaga ttacaaggac cagaagagca atgtgccaga ttcagcagcc     2280

atgttttgcc agcctgttta ccactctgga gagagaggcc acagaaaaca gcatccaact     2340

gttacataac aggatggggt gacacaggac gagcctattc aagaacacta caacaagcag     2400

ccattccctt acttcctaaa aggttttgtg aagaacgtta taagggtcgg tttacaggga     2460

gaatgctttg tgctggaaac ctccatgaac acaaacgcgt ggacagctgc cagggagaca     2520

gcggaggacc actcatgtgt gaacggcccg gagagagctg ggtggtgtat ggggtgacct     2580

cctgggggta tggctgtgga gtcaaggatt ctcctggtgt ttataccaaa gtctcagcct     2640

ttgtaccttg gataaaaagt gtcaccaaac tgtaattctt catggaaact tcaaagcagc     2700

atttaaacaa atggaaaact ttgaaccccc actattagca ctcagcagag atgacaacaa     2760

atggcaagat ctgtttttgc tttgtgttgt ggtaaaaaat tgtgtacccc ctgctgcttt     2820

tgagaaattt gtgaacattt tcagaggcct cagtgtagtg gaagtgataa tccttaaatg     2880

aacattttct accctaattt cactggagtg acttattcta agcctcatct atcccctacc     2940

tatttctcaa aatcattcta tgctgatttt acaaaagatc atttttacat ttgaactgag     3000

aacccctttt aattgaatca gtggtgtctg aaatcatatt aaatacccac atttgacata     3060

aatgcggtac cctttactac actcatgagt ggcatattta tgcttaggtc ttttcaaaag     3120

acttgacaag aaatcttcat attctctgta gcctttgtca agtgaggaaa tcagtggtta     3180

aagaattcca ctataaactt ttaggcctga ataggagtag taaagcctca aggacatctg     3240

cctgtcacaa tatattctca aagtgatctg atatttggaa acaagtatcc ttgttgagta     3300

ccaagtgcta cagaaaccat aagataaaaa tactttctac ctacagcgta taaactagca     3360

aaatttgaaa ggatttctgg taactaaatg ccagctggac atacaaccta ttttatccaa     3420

cacattaaca tatctactat atttgctttt aacaagcacc tcatcatagt ccacgttccc     3480

cgaccatgat gtaagagtgc cacccactga cacttccctg taactgactt atacctgcag     3540

gttttcccaa gcccaacctg atacaatcca atcttaaaat atactagtca aaatgctttc     3600

ctggcctaca cattgaaaag ttctaataca tacagcagtt ataacatatg ccaggcactg     3660

cattaggcag ctttgcacat cactgacaat ttgcaaaagg ccagtaaatc ttatggtagt     3720

agcccttgtt ttcaaatggg ggaaaacagg cttgcctcaa agtgagacca gttggtgaaa     3780

ctgattccaa actccagaaa aaatgctgat ttttttcccc atggttctcc tacctaaatg     3840

attggtttcc ctatggctat ttctccaaga gttaagggat agctgcttaa ctatgcacct     3900

ttacagaaca ttcttagcag taatgctcaa atttaaaagg cacactcaag atacttccat     3960

gtcatggatc cttccccagg tcccagtagt ataaatatag ggaagaggtt agcatgaact     4020

tacaaattgt tttaagtaat cctcttgaat gccagtcatt aaaggacttt gcccttctac     4080

atcaaattac atccttttca caaatcccca tttctgtaat aactggtgca aacctaaagg     4140

tgctttatag ttttactact ttgcagattt gcaatgctgc atataatgca gaagagcatt     4200

aaaaactttt gtaaaaactc atgattttga taaactttta aagtagcgtt tatatgtaaa     4260

tagaactaca catggcacac acacttgcac aagggcttca gaaaaacgtg caatataggt     4320

gagaaaaatg tctattgaaa ctttctcaca ggctgccctt ataattaaac tagtgttggg     4380

gcaagcaaca tctgtttcaa gtagatcagg gactagcaaa cctaaaaggc agcaagcagc     4440

ctgcagtttg ctcaatcctt aagaatacat ggttcataca acatgctttt actatgtctt     4500

aagtgtgact tttgaaagat acaagtgttc tgtgcatatt tgtgtaaata aatacataat     4560

tttccacctt gta                                                        4573


<210>  568
<211>  875
<212>  PRT
<213>  Homo Sapiens

<400>  568

Met Thr Leu Ala Arg Phe Val Leu Ala Leu Met Leu Gly Ala Leu Pro 
1               5                   10                  15      


Glu Val Val Gly Phe Asp Ser Val Leu Asn Asp Ser Leu His His Ser 
            20                  25                  30          


His Arg His Ser Pro Pro Ala Gly Pro His Tyr Pro Tyr Tyr Leu Pro 
        35                  40                  45              


Thr Gln Gln Arg Pro Pro Arg Thr Arg Pro Pro Pro Pro Leu Pro Arg 
    50                  55                  60                  


Phe Pro Arg Pro Pro Arg Ala Leu Pro Ala Gln Arg Pro His Ala Leu 
65                  70                  75                  80  


Gln Ala Gly His Thr Pro Arg Pro His Pro Trp Gly Cys Pro Ala Gly 
                85                  90                  95      


Glu Pro Trp Val Ser Val Thr Asp Phe Gly Ala Pro Cys Leu Arg Trp 
            100                 105                 110         


Ala Glu Val Pro Pro Phe Leu Glu Arg Ser Pro Pro Ala Ser Trp Ala 
        115                 120                 125             


Gln Leu Arg Gly Gln Arg His Asn Phe Cys Arg Ser Pro Asp Gly Ala 
    130                 135                 140                 


Gly Arg Pro Trp Cys Phe Tyr Gly Asp Ala Arg Gly Lys Val Asp Trp 
145                 150                 155                 160 


Gly Tyr Cys Asp Cys Arg His Gly Ser Val Arg Leu Arg Gly Gly Lys 
                165                 170                 175     


Asn Glu Phe Glu Gly Thr Val Glu Val Tyr Ala Ser Gly Val Trp Gly 
            180                 185                 190         


Thr Val Cys Ser Ser His Trp Asp Asp Ser Asp Ala Ser Val Ile Cys 
        195                 200                 205             


His Gln Leu Gln Leu Gly Gly Lys Gly Ile Ala Lys Gln Thr Pro Phe 
    210                 215                 220                 


Ser Gly Leu Gly Leu Ile Pro Ile Tyr Trp Ser Asn Val Arg Cys Arg 
225                 230                 235                 240 


Gly Asp Glu Glu Asn Ile Leu Leu Cys Glu Lys Asp Ile Trp Gln Gly 
                245                 250                 255     


Gly Val Cys Pro Gln Lys Met Ala Ala Ala Val Thr Cys Ser Phe Ser 
            260                 265                 270         


His Gly Pro Thr Phe Pro Ile Ile Arg Leu Ala Gly Gly Ser Ser Val 
        275                 280                 285             


His Glu Gly Arg Val Glu Leu Tyr His Ala Gly Gln Trp Gly Thr Val 
    290                 295                 300                 


Cys Asp Asp Gln Trp Asp Asp Ala Asp Ala Glu Val Ile Cys Arg Gln 
305                 310                 315                 320 


Leu Gly Leu Ser Gly Ile Ala Lys Ala Trp His Gln Ala Tyr Phe Gly 
                325                 330                 335     


Glu Gly Ser Gly Pro Val Met Leu Asp Glu Val Arg Cys Thr Gly Asn 
            340                 345                 350         


Glu Leu Ser Ile Glu Gln Cys Pro Lys Ser Ser Trp Gly Glu His Asn 
        355                 360                 365             


Cys Gly His Lys Glu Asp Ala Gly Val Ser Cys Thr Pro Leu Thr Asp 
    370                 375                 380                 


Gly Val Ile Arg Leu Ala Gly Gly Lys Gly Ser His Glu Gly Arg Leu 
385                 390                 395                 400 


Glu Val Tyr Tyr Arg Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp 
                405                 410                 415     


Thr Glu Leu Asn Thr Tyr Val Val Cys Arg Gln Leu Gly Phe Lys Tyr 
            420                 425                 430         


Gly Lys Gln Ala Ser Ala Asn His Phe Glu Glu Ser Thr Gly Pro Ile 
        435                 440                 445             


Trp Leu Asp Asp Val Ser Cys Ser Gly Lys Glu Thr Arg Phe Leu Gln 
    450                 455                 460                 


Cys Ser Arg Arg Gln Trp Gly Arg His Asp Cys Ser His Arg Glu Asp 
465                 470                 475                 480 


Val Ser Ile Ala Cys Tyr Pro Gly Gly Glu Gly His Arg Leu Ser Leu 
                485                 490                 495     


Gly Phe Pro Val Arg Leu Met Asp Gly Glu Asn Lys Lys Glu Gly Arg 
            500                 505                 510         


Val Glu Val Phe Ile Asn Gly Gln Trp Gly Thr Ile Cys Asp Asp Gly 
        515                 520                 525             


Trp Thr Asp Lys Asp Ala Ala Val Ile Cys Arg Gln Leu Gly Tyr Lys 
    530                 535                 540                 


Gly Pro Ala Arg Ala Arg Thr Met Ala Tyr Phe Gly Glu Gly Lys Gly 
545                 550                 555                 560 


Pro Ile His Val Asp Asn Val Lys Cys Thr Gly Asn Glu Arg Ser Leu 
                565                 570                 575     


Ala Asp Cys Ile Lys Gln Asp Ile Gly Arg His Asn Cys Arg His Ser 
            580                 585                 590         


Glu Asp Ala Gly Val Ile Cys Asp Tyr Phe Gly Lys Lys Ala Ser Gly 
        595                 600                 605             


Asn Ser Asn Lys Glu Ser Leu Ser Ser Val Cys Gly Leu Arg Leu Leu 
    610                 615                 620                 


His Arg Arg Gln Lys Arg Ile Ile Gly Gly Lys Asn Ser Leu Arg Gly 
625                 630                 635                 640 


Gly Trp Pro Trp Gln Val Ser Leu Arg Leu Lys Ser Ser His Gly Asp 
                645                 650                 655     


Gly Arg Leu Leu Cys Gly Ala Thr Leu Leu Ser Ser Cys Trp Val Leu 
            660                 665                 670         


Thr Ala Ala His Cys Phe Lys Arg Tyr Gly Asn Ser Thr Arg Ser Tyr 
        675                 680                 685             


Ala Val Arg Val Gly Asp Tyr His Thr Leu Val Pro Glu Glu Phe Glu 
    690                 695                 700                 


Glu Glu Ile Gly Val Gln Gln Ile Val Ile His Arg Glu Tyr Arg Pro 
705                 710                 715                 720 


Asp Arg Ser Asp Tyr Asp Ile Ala Leu Val Arg Leu Gln Gly Pro Glu 
                725                 730                 735     


Glu Gln Cys Ala Arg Phe Ser Ser His Val Leu Pro Ala Cys Leu Pro 
            740                 745                 750         


Leu Trp Arg Glu Arg Pro Gln Lys Thr Ala Ser Asn Cys Tyr Ile Thr 
        755                 760                 765             


Gly Trp Gly Asp Thr Gly Arg Ala Tyr Ser Arg Thr Leu Gln Gln Ala 
    770                 775                 780                 


Ala Ile Pro Leu Leu Pro Lys Arg Phe Cys Glu Glu Arg Tyr Lys Gly 
785                 790                 795                 800 


Arg Phe Thr Gly Arg Met Leu Cys Ala Gly Asn Leu His Glu His Lys 
                805                 810                 815     


Arg Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Met Cys Glu 
            820                 825                 830         


Arg Pro Gly Glu Ser Trp Val Val Tyr Gly Val Thr Ser Trp Gly Tyr 
        835                 840                 845             


Gly Cys Gly Val Lys Asp Ser Pro Gly Val Tyr Thr Lys Val Ser Ala 
    850                 855                 860                 


Phe Val Pro Trp Ile Lys Ser Val Thr Lys Leu 
865                 870                 875 


<210>  569
<211>  2152
<212>  DNA
<213>  Homo Sapiens

<400>  569
ttcgtagttt cctgataacc attcagtcat ctatttcaac accctgacat gacataaagg       60

caggcacgga accacacgtt caccatacag acacacgcca ctttgctgga gcattcacta      120

ggcgaggcgc tccatcggac tcactagctg cactcatgaa tcggcaccat ctgcaggatc      180

actttctgga aatagacaag aagaactgct gtgtgttccg agatgacttc attgccaagg      240

tgttgccgcc ggtgttgggg ctggagttta tctttgggct tctgggcaat ggccttgccc      300

tgtggatttt ctgtttccac ctcaagtcct ggaaatccag ccggattttc ctgttcaacc      360

tggcagtagc tgactttcta ctgatcatct gcctgccgtt cgtgatggac tactatgtgc      420

ggcgttcaga ctggaagttt ggggacatcc cttgccggct ggtgctcttc atgtttgcca      480

tgaaccgcca gggcagcatc atattcctca cggtggtggc ggtagacagg tatttccggg      540

tggtccatcc ccaccacgcc ctgaacaaga tctccaattg gacagcagcc atcatctctt      600

gccttctgtg gggcatcact gttggcctaa cagtccacct cctgaagaag aagttgctga      660

tccagaatgg cactgcaaat gtgtgcatca gcttcagcat ctgccatacc ttccggtggc      720

acgaagctat gttcctcctg gagttcttcc tgcccctggg catcatcctg ttctgctcag      780

ccagaattat ctggagcctg cggcagagac aaatggaccg gcatgccaag atcaagagag      840

ccatcacctt catcatggtg gtggccatcg tctttgtcat ctgcttcctt cccagcgtgg      900

ttgtgcggat ccacatcttc tggctcctgc acacttcggg cacgcagaat tgtgaagtgt      960

accgctcggt ggacctggcg ttctttatca ctctcagctt cacctacatg aacagcatgc     1020

tggaccccgt ggtgtactac ttctccagcc catcctttcc caacttcttc tccactttga     1080

tcaaccgctg cctccagagg aagataacag gtgagccaga taataaccgc agcacgagcg     1140

tcgagctcac aggggacccc aacaaaacca gaggcgctcc agaggcgtta atcgccaact     1200

ccggtgagcc atggagcccc tcttatctgg gcccaacctc aaataaccat tccaagaagg     1260

gacattgtca ccaagaacca gcatctctgg agaaacagtt gggctgttgc atcgagtaat     1320

gtcactggac tcggcctaag atttcctgga acttccagat tcagagaatc tgatttaggg     1380

aaactgtggc agatgagtgg gagactggtt gcaaggtgtg accgcaggaa tcctggagga     1440

acagagagta aagcttctag gcatctgaaa cttgcttcat ctctgacgct cgcaggactg     1500

aagatgggca aattgtaggc gtttctgctg agcagagttg gagccagaga tctacttgtg     1560

acttgttggc cttcttccca catctgcctc agactggagg gggctcagct cctggggtga     1620

tatctagcct gcttgtgagc tctagcaggg ataaggagag ctgagattgg agggaattgt     1680

gttgttcctg gaggaagccc aggcatcatt aaacaagcca gtaggtcacc tggcttccgt     1740

ggaccaattc atctttcaga caatctttag cagaaatgga ctcagggaag agactcacat     1800

gctttggtta gtatctgtgt ttccggtggg tgtaataggg gattagcccc agaagggact     1860

gagctaaaca gtgttattat gggaaaggaa atggcattgc tgctttcaac cagcgactaa     1920

tgcaatccat tcctctcttg tttatagtaa tctaagggtt gaacagttaa aacggcttca     1980

ggatagaaag ctgtttccca cctgtttgct tttaccatta aaagggaaac gtgcctctgc     2040

cccacgggta gaggggtgca cgttcctcct ggttccttcg cttgtgtttc tgtacttacc     2100

aaaaatctac catttcaata aattttgata ggagacaaaa aaaaaaaaaa aa             2152


<210>  570
<211>  387
<212>  PRT
<213>  Homo Sapiens

<400>  570

Met Asn Arg His His Leu Gln Asp His Phe Leu Glu Ile Asp Lys Lys 
1               5                   10                  15      


Asn Cys Cys Val Phe Arg Asp Asp Phe Ile Ala Lys Val Leu Pro Pro 
            20                  25                  30          


Val Leu Gly Leu Glu Phe Ile Phe Gly Leu Leu Gly Asn Gly Leu Ala 
        35                  40                  45              


Leu Trp Ile Phe Cys Phe His Leu Lys Ser Trp Lys Ser Ser Arg Ile 
    50                  55                  60                  


Phe Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu Ile Ile Cys Leu 
65                  70                  75                  80  


Pro Phe Val Met Asp Tyr Tyr Val Arg Arg Ser Asp Trp Lys Phe Gly 
                85                  90                  95      


Asp Ile Pro Cys Arg Leu Val Leu Phe Met Phe Ala Met Asn Arg Gln 
            100                 105                 110         


Gly Ser Ile Ile Phe Leu Thr Val Val Ala Val Asp Arg Tyr Phe Arg 
        115                 120                 125             


Val Val His Pro His His Ala Leu Asn Lys Ile Ser Asn Trp Thr Ala 
    130                 135                 140                 


Ala Ile Ile Ser Cys Leu Leu Trp Gly Ile Thr Val Gly Leu Thr Val 
145                 150                 155                 160 


His Leu Leu Lys Lys Lys Leu Leu Ile Gln Asn Gly Thr Ala Asn Val 
                165                 170                 175     


Cys Ile Ser Phe Ser Ile Cys His Thr Phe Arg Trp His Glu Ala Met 
            180                 185                 190         


Phe Leu Leu Glu Phe Phe Leu Pro Leu Gly Ile Ile Leu Phe Cys Ser 
        195                 200                 205             


Ala Arg Ile Ile Trp Ser Leu Arg Gln Arg Gln Met Asp Arg His Ala 
    210                 215                 220                 


Lys Ile Lys Arg Ala Ile Thr Phe Ile Met Val Val Ala Ile Val Phe 
225                 230                 235                 240 


Val Ile Cys Phe Leu Pro Ser Val Val Val Arg Ile His Ile Phe Trp 
                245                 250                 255     


Leu Leu His Thr Ser Gly Thr Gln Asn Cys Glu Val Tyr Arg Ser Val 
            260                 265                 270         


Asp Leu Ala Phe Phe Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
        275                 280                 285             


Leu Asp Pro Val Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Asn Phe 
    290                 295                 300                 


Phe Ser Thr Leu Ile Asn Arg Cys Leu Gln Arg Lys Ile Thr Gly Glu 
305                 310                 315                 320 


Pro Asp Asn Asn Arg Ser Thr Ser Val Glu Leu Thr Gly Asp Pro Asn 
                325                 330                 335     


Lys Thr Arg Gly Ala Pro Glu Ala Leu Ile Ala Asn Ser Gly Glu Pro 
            340                 345                 350         


Trp Ser Pro Ser Tyr Leu Gly Pro Thr Ser Asn Asn His Ser Lys Lys 
        355                 360                 365             


Gly His Cys His Gln Glu Pro Ala Ser Leu Glu Lys Gln Leu Gly Cys 
    370                 375                 380                 


Cys Ile Glu 
385         


<210>  571
<211>  1892
<212>  DNA
<213>  Homo Sapiens

<400>  571
ggcgcccgcg cccgcccccg cgccgggccc ggctcggccc gacccggctc cgccgcgggc       60

aggcggggcc cagcgcactc ggagcccgag cccgagccgc agccgccgcc tggggcgctt      120

gggtcggcct cgaggacacc ggagaggggc gccacgccgc cgtggccgca gatttgaaag      180

aagccaacac taaaccacaa atatacaaca aggccatttt ctcaaacgag agtcagcctt      240

taacgaaatg accatggttg acacagagat gccattctgg cccaccaact ttgggatcag      300

ctccgtggat ctctccgtaa tggaagacca ctcccactcc tttgatatca agcccttcac      360

tactgttgac ttctccagca tttctactcc acattacgaa gacattccat tcacaagaac      420

agatccagtg gttgcagatt acaagtatga cctgaaactt caagagtacc aaagtgcaat      480

caaagtggag cctgcatctc caccttatta ttctgagaag actcagctct acaataagcc      540

tcatgaagag ccttccaact ccctcatggc aattgaatgt cgtgtctgtg gagataaagc      600

ttctggattt cactatggag ttcatgcttg tgaaggatgc aagggtttct tccggagaac      660

aatcagattg aagcttatct atgacagatg tgatcttaac tgtcggatcc acaaaaaaag      720

tagaaataaa tgtcagtact gtcggtttca gaaatgcctt gcagtgggga tgtctcataa      780

tgccatcagg tttgggcgga tgccacaggc cgagaaggag aagctgttgg cggagatctc      840

cagtgatatc gaccagctga atccagagtc cgctgacctc cgggccctgg caaaacattt      900

gtatgactca tacataaagt ccttcccgct gaccaaagca aaggcgaggg cgatcttgac      960

aggaaagaca acagacaaat caccattcgt tatctatgac atgaattcct taatgatggg     1020

agaagataaa atcaagttca aacacatcac ccccctgcag gagcagagca aagaggtggc     1080

catccgcatc tttcagggct gccagtttcg ctccgtggag gctgtgcagg agatcacaga     1140

gtatgccaaa agcattcctg gttttgtaaa tcttgacttg aacgaccaag taactctcct     1200

caaatatgga gtccacgaga tcatttacac aatgctggcc tccttgatga ataaagatgg     1260

ggttctcata tccgagggcc aaggcttcat gacaagggag tttctaaaga gcctgcgaaa     1320

gccttttggt gactttatgg agcccaagtt tgagtttgct gtgaagttca atgcactgga     1380

attagatgac agcgacttgg caatatttat tgctgtcatt attctcagtg gagaccgccc     1440

aggtttgctg aatgtgaagc ccattgaaga cattcaagac aacctgctac aagccctgga     1500

gctccagctg aagctgaacc accctgagtc ctcacagctg tttgccaagc tgctccagaa     1560

aatgacagac ctcagacaga ttgtcacgga acacgtgcag ctactgcagg tgatcaagaa     1620

gacggagaca gacatgagtc ttcacccgct cctgcaggag atctacaagg acttgtacta     1680

gcagagagtc ctgagccact gccaacattt cccttcttcc agttgcacta ttctgaggga     1740

aaatctgaca cctaagaaat ttactgtgaa aaagcatttt aaaaagaaaa ggttttagaa     1800

tatgatctat tttatgcata ttgtttataa agacacattt acaatttact tttaatatta     1860

aaaattacca tattatgaaa ttgctgatag ta                                   1892


<210>  572
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  572

Met Thr Met Val Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly 
1               5                   10                  15      


Ile Ser Ser Val Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe 
            20                  25                  30          


Asp Ile Lys Pro Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro 
        35                  40                  45              


His Tyr Glu Asp Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp 
    50                  55                  60                  


Tyr Lys Tyr Asp Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val 
65                  70                  75                  80  


Glu Pro Ala Ser Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn 
                85                  90                  95      


Lys Pro His Glu Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg 
            100                 105                 110         


Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys 
        115                 120                 125             


Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile 
    130                 135                 140                 


Tyr Asp Arg Cys Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn 
145                 150                 155                 160 


Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser 
                165                 170                 175     


His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys 
            180                 185                 190         


Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser 
        195                 200                 205             


Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
    210                 215                 220                 


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
225                 230                 235                 240 


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met 
                245                 250                 255     


Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu 
            260                 265                 270         


Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg 
        275                 280                 285             


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
    290                 295                 300                 


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
305                 310                 315                 320 


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
                325                 330                 335     


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
            340                 345                 350         


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
        355                 360                 365             


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
    370                 375                 380                 


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
385                 390                 395                 400 


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
                405                 410                 415     


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
            420                 425                 430         


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
        435                 440                 445             


His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser 
    450                 455                 460                 


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
465                 470                 475         


<210>  573
<211>  1536
<212>  DNA
<213>  Homo Sapiens

<400>  573
ataaatgcgc agcctgagag ggggtgagct gacactgtcc cagctgccac ctagactcgg       60

agctccatcc aaacctccag cgaagacatc ccaggtcggg tgaatcttcc agccctgggg      120

gtggaggtag taaaggccat ggccatgcag aaaatctttg cccgggaaat cttggactcc      180

aggggcaacc ccacggtgga ggtggacctg cacacggcca agggccgatt ccgagcagct      240

gtgcccagtg gggcttccac gggtatctat gaggctctgg aactaagaga cggagacaaa      300

ggccgctacc tggggaaagg agtcctgaag gctgtggaga acatcaacaa tactctgggc      360

cctgctctgc tgcaaaagaa actaagcgtt gtggatcaag aaaaagttga caaatttatg      420

attgagctag atgggaccga gaataagtcc aagtttgggg ccaatgccat cctgggcgtg      480

tccttggccg tgtgtaaggc gggagcagct gagaaggggg tccccctgta ccgccacatc      540

gcagatctcg ctgggaaccc tgacctcata ctcccagtgc cagccttcaa tgtgatcaac      600

gggggctccc atgctggaaa caagctggcc atgcaggagt tcatgattct gcctgtggga      660

gccagctcct tcaaggaagc catgcgcatt ggcgccgagg tctaccacca cctcaagggg      720

gtcatcaagg ccaagtatgg gaaggatgcc accaatgtgg gtgatgaagg tggcttcgca      780

cccaacatcc tggagaacaa tgaggccctg gagctgctga agacggccat ccaggcggct      840

ggttacccag acaaggtggt gatcggcatg gatgtggcag catctgagtt ctatcgcaat      900

gggaagtacg atcttgactt caagtcgcct gatgatcccg cacggcacat cactggggag      960

aagctcggag agctgtataa gagctttatc aagaactatc ctgtggtctc catcgaagac     1020

ccctttgacc aggatgactg ggccacttgg acctccttcc tctcgggggt gaacatccag     1080

attgtggggg atgacttgac agtcaccaac cccaagagga ttgcccaggc cgttgagaag     1140

aaggcctgca actgtctgct gctgaaggtc aaccagatcg gctcggtgac cgaatcgatc     1200

caggcgtgca aactggctca gtctaatggc tggggggtga tggtgagcca ccgctctggg     1260

gagactgagg acacattcat tgctgacctt gtggtggggc tctgcacagg acagatcaag     1320

actggcgccc cctgccgctc ggagcgtctg gccaaataca accaactcat gaggatcgag     1380

gaggctcttg gggacaaggc aatctttgct ggacgcaagt tccgtaaccc gaaggccaag     1440

tgagaagctg gaggctccag gactccactg gacagaccca ggtcttccag acctgcttcc     1500

tgaaataaac actggtgcca accaagaaaa aaaaaa                               1536


<210>  574
<211>  434
<212>  PRT
<213>  Homo Sapiens

<400>  574

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Glu Asn Ile Asn Asn Thr Leu Gly Pro Ala Leu Leu Gln Lys 
65                  70                  75                  80  


Lys Leu Ser Val Val Asp Gln Glu Lys Val Asp Lys Phe Met Ile Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His His Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Asn Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly Tyr Pro Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asn Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ala Arg His Ile Thr 
            260                 265                 270         


Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe Ile Lys Asn Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Thr Trp 
    290                 295                 300                 


Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala Val Glu Lys Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Ala 
                405                 410                 415     


Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys Phe Arg Asn Pro Lys 
            420                 425                 430         


Ala Lys 
        


<210>  575
<211>  1058
<212>  RNA
<213>  Homo Sapiens

<400>  575
accgaccaca acagcggaag agacaggaaa ccaccaagag aagcgccaca gacccgccgg       60

aaaaaacaaa aacgccaaaa aacggagcaa agggcagagg cggagccgcc aaggcggcgc      120

agcgggaccg agcagagaac caacggagaa cagcccaccg agaaaccaca aagcggaaca      180

ggacagagaa aggaaaagaa gaagaagacc aaaaaaagag acccacaccc agcaacaccc      240

accagagaag agcgaaaggg acgcaaggaa caaaaggaaa cgcaccaagg caggagccaa      300

agagccaaag aacacaagcg acggagagga gagggagcac cagaggacac aggagagacc      360

aggaggggaa aacgaccccc aggaaaaaga aaaggaccgg aaacacaaaa aggaaaaaaa      420

aagaccaaac gagacagagg ccagaagaag aaacgcgcaa cgggagaaga aaaagagaca      480

cacaaacacc cacacaaaaa aaacacagca agggaacaaa cccagcaagc caagcaagaa      540

aaaaaggcaa aaaaaaaaac cagaaaaacg gaaagagaca agagcgcggc acaaacgaaa      600

aaagaaaaag ggaaaaaaca ggaaagcaaa aaacagagag acagacccca acgaggacga      660

aaaggaacaa gggacccggg aagaaagcca acgcgaagaa ccgagaagca agggagagga      720

gaaaccgaca aaaaaaagcc agacacaaaa ccagcgaaag aggagacgac cgaagaacac      780

cacagcacga agacagaaga aaacaggaag ggagaaacaa acgccccaag gccgccacaa      840

acaaacggga ggcacacagg agcaacacag agaacaggcc aagacacaaa accccggacg      900

aaaccagaaa acaacagaga agccggaagc aaaaaaccaa gagaagcaag aagcaaggcc      960

caaagagaaa cagaacacca aagaggaaac agcagcacac agaaacaaga aaaagcacgg     1020

aaggaaaaga agcgacaagc aacaaaaaaa gagaaaca                             1058


<210>  576
<211>  1947
<212>  DNA
<213>  Homo Sapiens

<400>  576
acagtgtcca gaatgctgga gcgtaggtga aaggacaaaa gccagacaca tttcaacatg       60

agggacccac tgacagattg tccgtataat aaagtataca agaacctaaa ggagttttct      120

caaaatggag agaatttctg caaacaggtc acatctgttc ttcagcaaag ggcaaacctg      180

gaaattagct atgccaaagg acttcagaaa ctggcaagca agctgagcaa agcattacag      240

aacacgagaa aaagttgtgt tagcagtgcc tgggcctggg cctcagaggg aatgaaatcc      300

acagcggacc tgcatcaaaa acttggcaaa gcaattgaat tggaagcaat aaaaccgact      360

tatcaagtcc taaatgtaca agagaagaag agaaaatcac ttgacaatga agttgaaaag      420

acagcaaatc ttgtcattag caactggaat cagcaaatta aggccaagaa gaaattaatg      480

gttagtacca agaaacatga agcacttttc cagcttgtag aaagctccaa gcaatctatg      540

actgagaagg agaagcggaa gctcctcaat aaactgacaa aatcaactga aaagttggaa      600

aaggaagatg aaaattacta ccaaaaaaac atggcgggtt attctaccag actgaaatgg      660

gaaaacacac tagagaactg ctaccagagc attctggagc tggagaagga aagaattcaa      720

cttttatgca ataacttaaa ccagtacagc caacatattt ctctttttgg ccaaaccctg      780

accacatgcc acacgcagat tcactgtgcc atcagcaaga ttgacattga aaaagatatc      840

caggctgtaa tggaagaaac tgcaatttta tctacagaaa acaaatctga gttcctgtta      900

acggattact ttgaagaaga tcctaacagt gcaatggata aagagagacg aaagtcttta      960

ctaaaaccaa aattattgag actgcagaga gacattgaaa aagcctcaaa agacaaggaa     1020

ggcctggaac gaatgcttaa aacgtactcc agcacctcct ccttctctga tgcaaagagc     1080

cagaaagaca cagcagcgtt aatggatgag aacaatttga aactagacct tttggaagcg     1140

aactcctaca aactgtcatc aatgttagca gaacttgagc aaagacctca acccagccat     1200

ccttgtagta attccatctt caggtggagg gaaaaggagc atactcatag ctatgtgaaa     1260

atatctcggc cttttttaat gaagagatta gagaatattg tgagcaaggc atcttctggt     1320

gggcagagca atccaggttc ttcaactcca gcccctggtg cagcccagct cagcagcaga     1380

ctttgcaagg ccttgtattc ttttcaagcc aggcaagatg atgagttgaa tttggaaaag     1440

ggtgacattg tgattataca cgagaaaaaa gaaggaggat ggtggtttgg atctttgaat     1500

gggaaaaaag gccattttcc tgccgcttat gtggaggagt taccttcaaa tgctggcaac     1560

acagctacaa aggcataaaa caagactctg aacatactac cttcacactc ggtaatcaac     1620

aatacagtgt ggttcaaata agaataaagt gctcttacct ttacatgttt ttcttttgaa     1680

atggatggag ttctacctgc atgtcacagc actttgcatt catgattatt agcttgaaac     1740

agtcagaaaa aagatggatg ggtggagaca gacaaggaag aggctccttg gttcctagag     1800

gagtttccaa attctaggag accctagaga tgatccagta taacccctgg tgtcacagaa     1860

acagacggag tccaaggtgg gttcagctgc ttgcctgaag tcagagttat ctggtagaca     1920

acagcagtgg gacttagatg tcttttt                                         1947


<210>  577
<211>  506
<212>  PRT
<213>  Homo Sapiens

<400>  577

Met Arg Asp Pro Leu Thr Asp Cys Pro Tyr Asn Lys Val Tyr Lys Asn 
1               5                   10                  15      


Leu Lys Glu Phe Ser Gln Asn Gly Glu Asn Phe Cys Lys Gln Val Thr 
            20                  25                  30          


Ser Val Leu Gln Gln Arg Ala Asn Leu Glu Ile Ser Tyr Ala Lys Gly 
        35                  40                  45              


Leu Gln Lys Leu Ala Ser Lys Leu Ser Lys Ala Leu Gln Asn Thr Arg 
    50                  55                  60                  


Lys Ser Cys Val Ser Ser Ala Trp Ala Trp Ala Ser Glu Gly Met Lys 
65                  70                  75                  80  


Ser Thr Ala Asp Leu His Gln Lys Leu Gly Lys Ala Ile Glu Leu Glu 
                85                  90                  95      


Ala Ile Lys Pro Thr Tyr Gln Val Leu Asn Val Gln Glu Lys Lys Arg 
            100                 105                 110         


Lys Ser Leu Asp Asn Glu Val Glu Lys Thr Ala Asn Leu Val Ile Ser 
        115                 120                 125             


Asn Trp Asn Gln Gln Ile Lys Ala Lys Lys Lys Leu Met Val Ser Thr 
    130                 135                 140                 


Lys Lys His Glu Ala Leu Phe Gln Leu Val Glu Ser Ser Lys Gln Ser 
145                 150                 155                 160 


Met Thr Glu Lys Glu Lys Arg Lys Leu Leu Asn Lys Leu Thr Lys Ser 
                165                 170                 175     


Thr Glu Lys Leu Glu Lys Glu Asp Glu Asn Tyr Tyr Gln Lys Asn Met 
            180                 185                 190         


Ala Gly Tyr Ser Thr Arg Leu Lys Trp Glu Asn Thr Leu Glu Asn Cys 
        195                 200                 205             


Tyr Gln Ser Ile Leu Glu Leu Glu Lys Glu Arg Ile Gln Leu Leu Cys 
    210                 215                 220                 


Asn Asn Leu Asn Gln Tyr Ser Gln His Ile Ser Leu Phe Gly Gln Thr 
225                 230                 235                 240 


Leu Thr Thr Cys His Thr Gln Ile His Cys Ala Ile Ser Lys Ile Asp 
                245                 250                 255     


Ile Glu Lys Asp Ile Gln Ala Val Met Glu Glu Thr Ala Ile Leu Ser 
            260                 265                 270         


Thr Glu Asn Lys Ser Glu Phe Leu Leu Thr Asp Tyr Phe Glu Glu Asp 
        275                 280                 285             


Pro Asn Ser Ala Met Asp Lys Glu Arg Arg Lys Ser Leu Leu Lys Pro 
    290                 295                 300                 


Lys Leu Leu Arg Leu Gln Arg Asp Ile Glu Lys Ala Ser Lys Asp Lys 
305                 310                 315                 320 


Glu Gly Leu Glu Arg Met Leu Lys Thr Tyr Ser Ser Thr Ser Ser Phe 
                325                 330                 335     


Ser Asp Ala Lys Ser Gln Lys Asp Thr Ala Ala Leu Met Asp Glu Asn 
            340                 345                 350         


Asn Leu Lys Leu Asp Leu Leu Glu Ala Asn Ser Tyr Lys Leu Ser Ser 
        355                 360                 365             


Met Leu Ala Glu Leu Glu Gln Arg Pro Gln Pro Ser His Pro Cys Ser 
    370                 375                 380                 


Asn Ser Ile Phe Arg Trp Arg Glu Lys Glu His Thr His Ser Tyr Val 
385                 390                 395                 400 


Lys Ile Ser Arg Pro Phe Leu Met Lys Arg Leu Glu Asn Ile Val Ser 
                405                 410                 415     


Lys Ala Ser Ser Gly Gly Gln Ser Asn Pro Gly Ser Ser Thr Pro Ala 
            420                 425                 430         


Pro Gly Ala Ala Gln Leu Ser Ser Arg Leu Cys Lys Ala Leu Tyr Ser 
        435                 440                 445             


Phe Gln Ala Arg Gln Asp Asp Glu Leu Asn Leu Glu Lys Gly Asp Ile 
    450                 455                 460                 


Val Ile Ile His Glu Lys Lys Glu Gly Gly Trp Trp Phe Gly Ser Leu 
465                 470                 475                 480 


Asn Gly Lys Lys Gly His Phe Pro Ala Ala Tyr Val Glu Glu Leu Pro 
                485                 490                 495     


Ser Asn Ala Gly Asn Thr Ala Thr Lys Ala 
            500                 505     


<210>  578
<211>  3346
<212>  DNA
<213>  Homo Sapiens

<400>  578
gcggaggcgg gcgcgcgccc cgcaggggag ggggcggaga gcgcgagaag gagggaggag       60

gcgtccccgt gcgggagccc ggctgaccgc gccagaccca gacagagcat cgcggctttg      120

gctgcaacag gcggtgggct cggctcgggg gcggaggcgg cgaaagggcg gggagcgcga      180

ggaggagcga cctggcctca ccgctgccgc ctcttccccg ccgcatggac gagcgcctca      240

gccttctgcg ctcgccgccg ccgccctcag cccgccaccg cgcccaccct cctcagcgcc      300

cagcgagcag cggcggtgcc cacacgctgg tgaaccacgg ctacgcggag cccgccgcag      360

gccgcgagct gccgcccgac atgaccgtgg tgcccgggga ccacctgctg gagccggagg      420

tggccgatgg tggaggggcc ccgcctcaag gcggctgtgg cggcggcggc tgcgaccgct      480

acgagccgct gccgccctca ctgccggccg cgggcgagca ggactgctgc ggggagcgcg      540

tggtcatcaa catctccggg ctgcgcttcg agacgcagct gaagaccctt tgccagttcc      600

ccgagacgct gctgggcgac cccaagcggc gcatgaggta cttcgacccg ctccgcaacg      660

agtacttctt cgaccgcaac cggcccagct tcgacgccat cctctactac tatcagtccg      720

ggggccgcat ccgccggccg gtcaacgtgc ccatcgacat tttctccgag gagatccgct      780

tctaccagct gggcgaggag gccatggaga agttccgcga ggacgagggc ttcctgcggg      840

aggaggagcg gcccttgccc cgccgcgact tccagcgcca ggtgtggctg ctcttcgagt      900

accccgagag ctccgggccg gcccggggca tcgccatcgt gtccgtgctg gtcatcctca      960

tctccattgt catcttctgc ctggagacgc tgccggagtt ccgcgacgag aaggactacc     1020

ccgcctcgac gtcgcaggac tcattcgaag cagccggcaa cagcacgtcg gggtcccgcg     1080

caggagcctc cagcttctcc gatcccttct tcgtggtgga gacgctgtgc atcatctggt     1140

tctccttcga actgctggtg cggttcttcg cttgtcctag caaagccacc ttctcgcgaa     1200

acatcatgaa cctgatcgac attgtggcca tcattcctta ttttatcact ctgggtaccg     1260

agctggccga acgacagggc aatggacagc aggccatgtc tctggccatc ctgagggtca     1320

tccgcctggt aagggtcttc cgcatcttca agctgtcgcg ccactccaag gggctgcaga     1380

tcctcgggca aacgctgaag gcgtccatgc gggagctggg attgctcatc ttcttcctct     1440

ttattggggt catccttttc tccagcgcgg tctactttgc cgaggcagac gaccccactt     1500

caggtttcag cagcatcccg gatgccttct ggtgggcagt ggtaaccatg acaacagtgg     1560

gttacggcga tatgcaccca gtgaccatag ggggcaagat tgtgggatct ctctgtgcca     1620

tcgccggtgt cttgaccatc gcattgccag ttcccgtgat tgtttccaac ttcaattact     1680

tctaccaccg ggagacagaa ggggaagagc aatcccagta catgcacgtg ggaagttgcc     1740

agcacctctc ctcttcagcc gaggagctcc gaaaagcaag gagtaactcg actctgagta     1800

agtcggagta tatggtgatc gaagaggggg gtatgaacca tagcgctttc ccccagaccc     1860

ctttcaaaac gggcaattcc actgccacct gcaccacgaa caataatccc aactcttgtg     1920

tcaacatcaa aaagatattc accgatgttt aatatgtgat acaagtgaca tgctgtgctc     1980

agtattgtgt ggaacgtgcc cccttggtct gcctatgccc ttgttttata catttccaga     2040

ccattcatca aggaaaggac ctgaagaagt ggaaagcaca cttcattctc cctctccctg     2100

ctgcttcata ctgaaacagg tgcctgtttt gcaagtgggc tgcattctct cagctctcct     2160

tttccctctt accctctctc tcttaacatt gtaaacaaca gacttacgtt aaacttcatt     2220

tctagtacac gccctattta aaaaagagca gtacatcctg ggaggaaatg aaactaaaga     2280

acagttagag taactgttta acctcagaat tttaaaggca gttgtttctt tcctaagcac     2340

atcaattcgt agtaaatgat gcttcggttt gatggacctt tcaacgttat ttattgaata     2400

tgtatttcgg ttgcctaccc tgtagatatg tggatgaaga gtctaactag aataatgact     2460

tgtaaaccca ccatgagtta tttggttttt gacttaaatt cctatttgaa tcccctttcc     2520

cggaatttta agtgtctcta caactttgaa taaagggaaa tgcccaagat gtcctgatct     2580

gactaattag tttaattctt tcgggcttgc taagcatttc taaagcatta gactaacaga     2640

ttcctgtgaa gttctgtgca tatgtcccag ccccaacaac tatcaaagtc tagaaacaga     2700

tgttttcagt gttgctgaga gaaacaaaaa atttcctaat gcatctgaga gataagcttc     2760

ggcagtatca caagaagatt aaagtggcag acaccccttc cagcggaagt tactaattcg     2820

gacctgactg atgcagtttc catagcaacc catgtttcct gggaaacccg aaaaaggttg     2880

tcatggcatc tcttgctctc tagccccacc tcccagcccc tgccgtttcc acagtaacct     2940

ttccagatgg ttcctactta aatgatttca taaggaaaac cactgtttga ataagccgca     3000

caaaaaataa agttaagtct gagactctaa ggaggtgaaa tgaatcccaa atgcattttt     3060

taactatgaa aatcattatg tcattccata atgactgaat caaggaggaa aatatggtgt     3120

ttggaatgtt agatattaac cacaataagg catgatctgg attaaatgcc atttattagg     3180

caataatttt taaagatgct tctctacagt tttctttctc caagaacttt caagccaaca     3240

aatgaaattt aaaagcaaat gtaaaagtgt tctgtacata agcaaatgag agattcgatc     3300

agtgtgcctg aaaccttact acaagggacc ttcaggcttt ctcttt                    3346


<210>  579
<211>  575
<212>  PRT
<213>  Homo Sapiens

<400>  579

Met Asp Glu Arg Leu Ser Leu Leu Arg Ser Pro Pro Pro Pro Ser Ala 
1               5                   10                  15      


Arg His Arg Ala His Pro Pro Gln Arg Pro Ala Ser Ser Gly Gly Ala 
            20                  25                  30          


His Thr Leu Val Asn His Gly Tyr Ala Glu Pro Ala Ala Gly Arg Glu 
        35                  40                  45              


Leu Pro Pro Asp Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro 
    50                  55                  60                  


Glu Val Ala Asp Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala 
                85                  90                  95      


Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly 
            100                 105                 110         


Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr 
        115                 120                 125             


Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg 
    130                 135                 140                 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu 
145                 150                 155                 160 


Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro 
                165                 170                 175     


Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu 
            180                 185                 190         


Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu 
        195                 200                 205             


Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe 
    210                 215                 220                 


Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser 
225                 230                 235                 240 


Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu 
                245                 250                 255     


Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp 
            260                 265                 270         


Ser Phe Glu Ala Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala 
        275                 280                 285             


Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile 
    290                 295                 300                 


Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys 
305                 310                 315                 320 


Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile 
                325                 330                 335     


Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly 
            340                 345                 350         


Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu 
        355                 360                 365             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    370                 375                 380                 


Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu 
385                 390                 395                 400 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                405                 410                 415     


Tyr Phe Ala Glu Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro 
            420                 425                 430         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        435                 440                 445             


Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys 
    450                 455                 460                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
465                 470                 475                 480 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln 
                485                 490                 495     


Ser Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala 
            500                 505                 510         


Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu 
        515                 520                 525             


Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln 
    530                 535                 540                 


Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn 
545                 550                 555                 560 


Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
                565                 570                 575 


<210>  580
<211>  7238
<212>  DNA
<213>  Homo Sapiens

<400>  580
gcactccggc cgggctctgc tggctgcggc gggagctgga cgcgggagga ggcggcggcg       60

gcgctggaac agtgaaccat ggagctgtat ttcggtgaat atcaacatgt gcagcaggaa      120

tatggggtcc atctgagact cgcaagtgat gatacccaaa aatcaaggag ttcccagaac      180

tccaaggcag gctcctacgg tgtcagtatt cgggtccagg gaattgatgg tcacccctat      240

attgtcctga ataacacaga acggtgccta gcaggcacat cgttttctga aaatgggcca      300

ccctttccac ctccagtgat aaataacctg cctctacatt ccagcaatgg ttctgtgcca      360

aaggagaaca gtgaagaact tcagcttcca gaaaacccat acgcccagcc tagcccaata      420

agaaacctga aacagcccct gctccatgag ggcaagaatg gagttctaga tcgcaaagac      480

gggtctgtga agccatctca cctgctgaac tttcagaggc atccagagct tttgcaaccc      540

tatgaccctg aaaagaatga gttgaattta caaaatcacc agccttctga gagtaattgg      600

ctaaaaacgt tgacagaaga aggcatcaac aataagaagc cttggacttg ctttcccaaa      660

cctagcaatt cccagcctac cagtccctcc ttggaagacc cggccaaatc tggtgtgaca      720

gctattcgtt tatgcagctc cgtggtcata gaggacccca aaaagcagac ctcagtgtgt      780

gtaaacgttc agagctgcac caaggagagg gtgggagagg aggccctttt cactagcggg      840

aggcccctga ctgcccacag cccacatgcc caccctgaaa ccaagaaaac caggccagat      900

gttcttccct tccggcgaca ggattcagcg ggacccgtcc tggatggagc tcggtcccgg      960

aggtcctcct cgtcatccac aactcccacg tcagccaact ctttgtacag gtttttactg     1020

gatgatcagg aatgtgccat ccatgccgac aacgtcaatc gtcatgaaaa cagaaggtat     1080

attcccttcc tgccaggaac tggacgggat attgatacag gatcaattcc tggtgtggat     1140

cagttaattg aaaaatttga tcaaaaacct gggcttcaga gaagaggaag gtctgggaag     1200

cgaaacagaa ttaatacaga tgacaggaaa agatccagaa gcgtggatag cgcctttcct     1260

tttggcctcc aagggaactc ggagtacctg attgaattca gtaggaactt gggcaagtca     1320

agcgaacacc tcctccggcc ttcccaggtg tgcccgcagc ggccactgtc tcaggagcgc     1380

cgtgggaaac agagcgtggg ccgcaccttt gcaaagctgc agggagcagc gcacggggct     1440

tcatgtgccc actccaggcc tccccagccg aacatagatg ggaaagttct ggaaaccgaa     1500

ggtagtcagg aaagtacagt gatccgtgcg ccctcccttg gtgcacagag taaaaaggag     1560

gaggaggtga aaacagccac cgctacgctg atgttacaga accgggcaac agcaacttcg     1620

cctgattctg gtgccaagaa aatttccgtg aagacatttc cttcggcctc aaatactcag     1680

gccacaccgg atctcttaaa gggccagcaa gagctcactc agcaaaccaa tgaggagaca     1740

gctaagcaga ttctctacaa ttacctcaaa gaaggaagca ctgataatga cgatgctact     1800

aaaaggaaag tcaacttggt ctttgagaaa atccagacct taaagtctcg agcagctggg     1860

agcgcccaag gaaataacca agcttgtaat tccacatctg aagtcaaaga tctattggaa     1920

cagaaaagca agttgaccat agaagtggct gaacttcaga gacagcttca actggaagtc     1980

aagaatcaac agaacattaa agaagagaga gagaggatga gagcaaacct agaagagctc     2040

cgaagccaac acaacgaaaa ggtggaggag aactccacat tgcagcaacg actggaagaa     2100

agtgaagggg agctccggaa gaatctggag gagctattcc aggtgaagat ggaacgggag     2160

cagcatcaga ctgagatcag ggatctccag gaccagctct cagaaatgca cgatgaactg     2220

gacagtgcaa agcgatcgga ggacagggag aagggagctc tgattgagga gctcttacag     2280

gcaaaacagg atcttcaaga tctgctgatt gccaaagagg agcaagaaga cctcttgaga     2340

aagcgagagc gtgaactcac cgccctgaag ggagccctga aagaagaggt ttccagccat     2400

gatcaggaga tggacaagct gaaggagcaa tatgatgctg agttgcaggc cctgagggag     2460

agtgtggaag aagcaaccaa gaatgtcgag gtcttggcga gcaggagcaa cacttcagag     2520

caagaccagg cggggactga aatgcgcgtg aagcttctgc aggaggagaa tgagaagctg     2580

cagggaagaa gcgaagagct ggagcggaga gttgctcagc ttcaaaggca gatcgaggac     2640

ctgaaaggcg atgaagccaa ggcgaaggaa acgctgaaga agtacgaggg agaaatacga     2700

cagttagagg aggcccttgt gcacgccaga aaggaagaaa aagaagctgt gtcagccaga     2760

agggccctgg agaatgaact ggaggctgct cagggaaatc tgagtcagac tacccaggag     2820

cagaagcagt tgtctgagaa gctcaaagag gagagtgagc agaaggagca gctaagaagg     2880

ttgaagaacg agatggagaa tgagcggtgg cacctgggca aaaccattga gaaactgcag     2940

aaggagatgg cagacattgt tgaggcctcc cgtacctcaa ccctggagct ccagaaccag     3000

ctggatgagt ataaggagaa aaaccgcagg gagctcgcag aaatgcaaag acagttgaag     3060

gagaaaacgc tggaggcaga aaagtcccga ctgacagcca tgaaaatgca ggatgagatg     3120

cgtctgatgg aggaagagtt acgggactac cagagagctc aggatgaagc actcacaaaa     3180

aggcagcttc tggagcagac gctgaaggac ctggagtatg agctggaagc caagagtcac     3240

ctcaaagatg accgcagcag gctggtcaag cagatggagg acaaggtgtc tcaactggag     3300

atggaactgg aagaagagag aaacaactca gatttgctgt ctgagaggat cagtaggagc     3360

agggaacaga tggagcagtt gaggaatgag ctacttcagg agagagctgc gagacaagac     3420

ttggagtgcg acaagatttc cctggagagg cagaacaagg acttaaagag ccggattatc     3480

cacctggaag gttcctacag gtccagcaaa gaggggctgg ttgtgcagat ggaggccagg     3540

atcgcggagc tggaggaccg cctggagagt gaggagaggg atcgggccaa tcttcagctc     3600

agcaaccggc ggctggagcg gaaagtgaag gagctggtga tgcaggtgga tgatgagcac     3660

ctgtcattga ctgatcagaa ggaccagctg agcttgcgtt tgaaagccat gaagcggcag     3720

gtggaggagg ctgaggagga aatcgacaga ctggaaagtt ctaaaaagaa gctgcagagg     3780

gagctggagg agcagatgga catgaatgag catctgcagg ggcagctcaa ctccatgaag     3840

aaggacttaa gactgaagaa gctgccgagt aaagtgctgg atgacatgga tgacgacgat     3900

gacctcagca cggatggggg aagcctctat gaggcgcctg tgagctacac attctccaag     3960

gacagcaccg tcgccagcca gatctgagtg ctctcccggg ctgtggaagt acctgtcatt     4020

cctgcaggag ctgcagccac ccaaagtggg aggcagggag gggagcatct gtctgccact     4080

gagaccaatc acagcctctt tgcacagcat gccagctcct cagtgttaca ttcctcgcca     4140

gggtctctca gtgggtcttc gacagagagc ttttgcagtt taaaatgttg ggatgcctga     4200

ggaccaggag ccaccaccca ctggggtgtt gtgagagata cactttggta ggctgaggcc     4260

cctgttccac agccactatt tgcattgctg tccctgcccc ctcatcactc cccctgccaa     4320

gacaaagggt ccagaaggct aggacttact taatagcact gtgcagggag gaaaccatgt     4380

atagcttgta catattttaa accagacctt ctcacgaact gctgctgttg ggtttggaat     4440

gtgatggagg cttggtaggg tggctggttt gtaaagttca tgcatctata ttgagtattc     4500

tttttttttt tttttgagat ggagtttcat tcttgttgcc gaggctggag tgcaatggcg     4560

caaccttggc tcactgcaac ctctgcctcc ctggttcaag tgattctcct gcctcatcct     4620

cccaagaagc tgagattaca gatgaccacc accactcctg gctaattttt tgtatttagt     4680

agagacgggg tttcaccatg ttggtcaggc tggtcttgaa ctcctgacct caggtgatcc     4740

acctgcctca gcctcccaaa gtgctgagat tacaggcatg agccaccacg cccagccatt     4800

gagtattctt ttttaaaata tgaagctatt agattttaag tgttgaggag cagaggtgag     4860

aagagagaga gagagagaaa gtcaaataaa gtcaaagacc agtttggaaa ccaaagttgg     4920

aaaagaagaa ttgtagtggt catggacagc taagactgag catagcagtt cacatggtct     4980

gggtaaacaa gtcactggca caggggaaag ccagaaggtt gcttgtgtct gtgactgcag     5040

ctatggcctt gtttgcttag tttatctgga attctgttat aatttctgaa ctgttctgag     5100

acctgttccc agtcactgat tgcaatttct tttacacagg ttgggtaggg agagttgtag     5160

gtaaggcctt aaacaaatga ggccgtttct ggaaggatag ggctgtgtgg tcatgtccca     5220

cagcaagctt ttgggatcgg gggaataaga gggtatgggg gaaaggttca tagacttagg     5280

tgtgagaatg aggtgggagg tgtctggtaa ggtcatgggg gaagggagat gagagaggag     5340

ataggcagat gtgggtatgg ggcccagtgt gagaaggaag acagagaagt tcttgaaagc     5400

tgggggatgt gtgggcaaga ggtggattga gcaggatctc agggttatgt cgaggaaggg     5460

aagaaagaaa cagaagtcag gcagaggcgt gtctgtgcaa actggaggac tccttccaac     5520

ttcctggaac aaagcgacat cgccagcagc aggctggcag ggagtggttg aggtctgggg     5580

gccaggccac atggctggag aggaatttca gggagcatag catcgggagg atgctacata     5640

tccagggact ccctcctggc cttcctgtgt cacttcacaa tgtgacagtc cccaggcatg     5700

cccacaggcc aggcccagtc acagctgggc ttccacaggt cagaatatgg gacaggacat     5760

ggtcagggag aggaccctgt gagttggtga catatatgtg gcagagatgg tagtgttcag     5820

ctgcttcagc agtgtcccca accatcccaa tagggtgggg gcctgtgggc cagaggactc     5880

catgacagta gccatggagt cccacctgtg ccaggtcaga gcccacccgg caggtttcag     5940

agtggtcagc ccagtttaag ggtgggagtc tggagccaga cagccaagcc ccttccacat     6000

ctacagggtc actgtcatcc tcaccacagc caggggtgat tctcacctct gcctgcttat     6060

gtggggtgtg gccgattcct ccctttagtc attcattcat ttagcacata tttattgggc     6120

atcggtgatg tgtcaggcac agtccttggc acacagaata cagcagtgaa ttaaacaggc     6180

aaaaattcct cccctcctgg agctcagtgt caggaaaggg ggtgataaat gacaatcaaa     6240

tcgacatgga ggttgagcac ctctgtactc agccctctgt ctgtccttct gaggacgcaa     6300

caagcctggt tccctagagc tcactttgac cctcaatatg ttcataattt ccctgctgct     6360

tctcccatcg ttagacatct gccagtaagc ctgctgagag aagcctcagc ccactcatac     6420

ctagagacgc tgctggggaa ggtcagcaca cccaagaact ttgggagtgt gtgtctgttt     6480

tggtttgtga gaaagtagct gcccctcatt ctggccagtt ctttccagta gccatggggc     6540

tggctacaag aagcaaaact gcccatgcaa agagaacaca ggtcactttt caaaacactt     6600

gcatcattac cctaaaaata ggctgttatg cgttttgaca attgcgctat cctacactct     6660

gagggagttg gcaacgcatg cggtatagtg gagtgggaag agttgagact gaaagttaag     6720

agaagggttt tcaagtcccg gctcatctca ccccagtgac tttgacagtg tgctcactct     6780

cagagccatg gattacctgg aacaaagtgc agattagtgc ccacggtcct ttccaggtat     6840

aacatgctat cgttctttaa ttttattata tatacatact tttcttctgt tttttgcttt     6900

aagaactaac cccgatcaag agtattttct ttagctagct taaaaagaaa acatatattt     6960

tatgtaaaaa cacatacatg gccaaatgca atactgaaga gacaatcatc ctgtatcttt     7020

tatggttttt cctgcttctg agtgtcgttc tacaatgccc gttgacttat tccattgcgt     7080

ctctgcttta gggtatggtt tggtcgcttt ggttgtcatg agaaagagac attctccttg     7140

cagctacctc catgtgagtg aattcctgga taaagcaaga tttcctttca ataaacgctg     7200

tcacccaatg ggaattttga ctctaaaaaa aaaaaaaa                             7238


<210>  581
<211>  1302
<212>  PRT
<213>  Homo Sapiens

<400>  581

Met Glu Leu Tyr Phe Gly Glu Tyr Gln His Val Gln Gln Glu Tyr Gly 
1               5                   10                  15      


Val His Leu Arg Leu Ala Ser Asp Asp Thr Gln Lys Ser Arg Ser Ser 
            20                  25                  30          


Gln Asn Ser Lys Ala Gly Ser Tyr Gly Val Ser Ile Arg Val Gln Gly 
        35                  40                  45              


Ile Asp Gly His Pro Tyr Ile Val Leu Asn Asn Thr Glu Arg Cys Leu 
    50                  55                  60                  


Ala Gly Thr Ser Phe Ser Glu Asn Gly Pro Pro Phe Pro Pro Pro Val 
65                  70                  75                  80  


Ile Asn Asn Leu Pro Leu His Ser Ser Asn Gly Ser Val Pro Lys Glu 
                85                  90                  95      


Asn Ser Glu Glu Leu Gln Leu Pro Glu Asn Pro Tyr Ala Gln Pro Ser 
            100                 105                 110         


Pro Ile Arg Asn Leu Lys Gln Pro Leu Leu His Glu Gly Lys Asn Gly 
        115                 120                 125             


Val Leu Asp Arg Lys Asp Gly Ser Val Lys Pro Ser His Leu Leu Asn 
    130                 135                 140                 


Phe Gln Arg His Pro Glu Leu Leu Gln Pro Tyr Asp Pro Glu Lys Asn 
145                 150                 155                 160 


Glu Leu Asn Leu Gln Asn His Gln Pro Ser Glu Ser Asn Trp Leu Lys 
                165                 170                 175     


Thr Leu Thr Glu Glu Gly Ile Asn Asn Lys Lys Pro Trp Thr Cys Phe 
            180                 185                 190         


Pro Lys Pro Ser Asn Ser Gln Pro Thr Ser Pro Ser Leu Glu Asp Pro 
        195                 200                 205             


Ala Lys Ser Gly Val Thr Ala Ile Arg Leu Cys Ser Ser Val Val Ile 
    210                 215                 220                 


Glu Asp Pro Lys Lys Gln Thr Ser Val Cys Val Asn Val Gln Ser Cys 
225                 230                 235                 240 


Thr Lys Glu Arg Val Gly Glu Glu Ala Leu Phe Thr Ser Gly Arg Pro 
                245                 250                 255     


Leu Thr Ala His Ser Pro His Ala His Pro Glu Thr Lys Lys Thr Arg 
            260                 265                 270         


Pro Asp Val Leu Pro Phe Arg Arg Gln Asp Ser Ala Gly Pro Val Leu 
        275                 280                 285             


Asp Gly Ala Arg Ser Arg Arg Ser Ser Ser Ser Ser Thr Thr Pro Thr 
    290                 295                 300                 


Ser Ala Asn Ser Leu Tyr Arg Phe Leu Leu Asp Asp Gln Glu Cys Ala 
305                 310                 315                 320 


Ile His Ala Asp Asn Val Asn Arg His Glu Asn Arg Arg Tyr Ile Pro 
                325                 330                 335     


Phe Leu Pro Gly Thr Gly Arg Asp Ile Asp Thr Gly Ser Ile Pro Gly 
            340                 345                 350         


Val Asp Gln Leu Ile Glu Lys Phe Asp Gln Lys Pro Gly Leu Gln Arg 
        355                 360                 365             


Arg Gly Arg Ser Gly Lys Arg Asn Arg Ile Asn Thr Asp Asp Arg Lys 
    370                 375                 380                 


Arg Ser Arg Ser Val Asp Ser Ala Phe Pro Phe Gly Leu Gln Gly Asn 
385                 390                 395                 400 


Ser Glu Tyr Leu Ile Glu Phe Ser Arg Asn Leu Gly Lys Ser Ser Glu 
                405                 410                 415     


His Leu Leu Arg Pro Ser Gln Val Cys Pro Gln Arg Pro Leu Ser Gln 
            420                 425                 430         


Glu Arg Arg Gly Lys Gln Ser Val Gly Arg Thr Phe Ala Lys Leu Gln 
        435                 440                 445             


Gly Ala Ala His Gly Ala Ser Cys Ala His Ser Arg Pro Pro Gln Pro 
    450                 455                 460                 


Asn Ile Asp Gly Lys Val Leu Glu Thr Glu Gly Ser Gln Glu Ser Thr 
465                 470                 475                 480 


Val Ile Arg Ala Pro Ser Leu Gly Ala Gln Ser Lys Lys Glu Glu Glu 
                485                 490                 495     


Val Lys Thr Ala Thr Ala Thr Leu Met Leu Gln Asn Arg Ala Thr Ala 
            500                 505                 510         


Thr Ser Pro Asp Ser Gly Ala Lys Lys Ile Ser Val Lys Thr Phe Pro 
        515                 520                 525             


Ser Ala Ser Asn Thr Gln Ala Thr Pro Asp Leu Leu Lys Gly Gln Gln 
    530                 535                 540                 


Glu Leu Thr Gln Gln Thr Asn Glu Glu Thr Ala Lys Gln Ile Leu Tyr 
545                 550                 555                 560 


Asn Tyr Leu Lys Glu Gly Ser Thr Asp Asn Asp Asp Ala Thr Lys Arg 
                565                 570                 575     


Lys Val Asn Leu Val Phe Glu Lys Ile Gln Thr Leu Lys Ser Arg Ala 
            580                 585                 590         


Ala Gly Ser Ala Gln Gly Asn Asn Gln Ala Cys Asn Ser Thr Ser Glu 
        595                 600                 605             


Val Lys Asp Leu Leu Glu Gln Lys Ser Lys Leu Thr Ile Glu Val Ala 
    610                 615                 620                 


Glu Leu Gln Arg Gln Leu Gln Leu Glu Val Lys Asn Gln Gln Asn Ile 
625                 630                 635                 640 


Lys Glu Glu Arg Glu Arg Met Arg Ala Asn Leu Glu Glu Leu Arg Ser 
                645                 650                 655     


Gln His Asn Glu Lys Val Glu Glu Asn Ser Thr Leu Gln Gln Arg Leu 
            660                 665                 670         


Glu Glu Ser Glu Gly Glu Leu Arg Lys Asn Leu Glu Glu Leu Phe Gln 
        675                 680                 685             


Val Lys Met Glu Arg Glu Gln His Gln Thr Glu Ile Arg Asp Leu Gln 
    690                 695                 700                 


Asp Gln Leu Ser Glu Met His Asp Glu Leu Asp Ser Ala Lys Arg Ser 
705                 710                 715                 720 


Glu Asp Arg Glu Lys Gly Ala Leu Ile Glu Glu Leu Leu Gln Ala Lys 
                725                 730                 735     


Gln Asp Leu Gln Asp Leu Leu Ile Ala Lys Glu Glu Gln Glu Asp Leu 
            740                 745                 750         


Leu Arg Lys Arg Glu Arg Glu Leu Thr Ala Leu Lys Gly Ala Leu Lys 
        755                 760                 765             


Glu Glu Val Ser Ser His Asp Gln Glu Met Asp Lys Leu Lys Glu Gln 
    770                 775                 780                 


Tyr Asp Ala Glu Leu Gln Ala Leu Arg Glu Ser Val Glu Glu Ala Thr 
785                 790                 795                 800 


Lys Asn Val Glu Val Leu Ala Ser Arg Ser Asn Thr Ser Glu Gln Asp 
                805                 810                 815     


Gln Ala Gly Thr Glu Met Arg Val Lys Leu Leu Gln Glu Glu Asn Glu 
            820                 825                 830         


Lys Leu Gln Gly Arg Ser Glu Glu Leu Glu Arg Arg Val Ala Gln Leu 
        835                 840                 845             


Gln Arg Gln Ile Glu Asp Leu Lys Gly Asp Glu Ala Lys Ala Lys Glu 
    850                 855                 860                 


Thr Leu Lys Lys Tyr Glu Gly Glu Ile Arg Gln Leu Glu Glu Ala Leu 
865                 870                 875                 880 


Val His Ala Arg Lys Glu Glu Lys Glu Ala Val Ser Ala Arg Arg Ala 
                885                 890                 895     


Leu Glu Asn Glu Leu Glu Ala Ala Gln Gly Asn Leu Ser Gln Thr Thr 
            900                 905                 910         


Gln Glu Gln Lys Gln Leu Ser Glu Lys Leu Lys Glu Glu Ser Glu Gln 
        915                 920                 925             


Lys Glu Gln Leu Arg Arg Leu Lys Asn Glu Met Glu Asn Glu Arg Trp 
    930                 935                 940                 


His Leu Gly Lys Thr Ile Glu Lys Leu Gln Lys Glu Met Ala Asp Ile 
945                 950                 955                 960 


Val Glu Ala Ser Arg Thr Ser Thr Leu Glu Leu Gln Asn Gln Leu Asp 
                965                 970                 975     


Glu Tyr Lys Glu Lys Asn Arg Arg Glu Leu Ala Glu Met Gln Arg Gln 
            980                 985                 990         


Leu Lys Glu Lys Thr Leu Glu Ala  Glu Lys Ser Arg Leu  Thr Ala Met 
        995                 1000                 1005             


Lys Met  Gln Asp Glu Met Arg  Leu Met Glu Glu Glu  Leu Arg Asp 
    1010                 1015                 1020             


Tyr Gln  Arg Ala Gln Asp Glu  Ala Leu Thr Lys Arg  Gln Leu Leu 
    1025                 1030                 1035             


Glu Gln  Thr Leu Lys Asp Leu  Glu Tyr Glu Leu Glu  Ala Lys Ser 
    1040                 1045                 1050             


His Leu  Lys Asp Asp Arg Ser  Arg Leu Val Lys Gln  Met Glu Asp 
    1055                 1060                 1065             


Lys Val  Ser Gln Leu Glu Met  Glu Leu Glu Glu Glu  Arg Asn Asn 
    1070                 1075                 1080             


Ser Asp  Leu Leu Ser Glu Arg  Ile Ser Arg Ser Arg  Glu Gln Met 
    1085                 1090                 1095             


Glu Gln  Leu Arg Asn Glu Leu  Leu Gln Glu Arg Ala  Ala Arg Gln 
    1100                 1105                 1110             


Asp Leu  Glu Cys Asp Lys Ile  Ser Leu Glu Arg Gln  Asn Lys Asp 
    1115                 1120                 1125             


Leu Lys  Ser Arg Ile Ile His  Leu Glu Gly Ser Tyr  Arg Ser Ser 
    1130                 1135                 1140             


Lys Glu  Gly Leu Val Val Gln  Met Glu Ala Arg Ile  Ala Glu Leu 
    1145                 1150                 1155             


Glu Asp  Arg Leu Glu Ser Glu  Glu Arg Asp Arg Ala  Asn Leu Gln 
    1160                 1165                 1170             


Leu Ser  Asn Arg Arg Leu Glu  Arg Lys Val Lys Glu  Leu Val Met 
    1175                 1180                 1185             


Gln Val  Asp Asp Glu His Leu  Ser Leu Thr Asp Gln  Lys Asp Gln 
    1190                 1195                 1200             


Leu Ser  Leu Arg Leu Lys Ala  Met Lys Arg Gln Val  Glu Glu Ala 
    1205                 1210                 1215             


Glu Glu  Glu Ile Asp Arg Leu  Glu Ser Ser Lys Lys  Lys Leu Gln 
    1220                 1225                 1230             


Arg Glu  Leu Glu Glu Gln Met  Asp Met Asn Glu His  Leu Gln Gly 
    1235                 1240                 1245             


Gln Leu  Asn Ser Met Lys Lys  Asp Leu Arg Leu Lys  Lys Leu Pro 
    1250                 1255                 1260             


Ser Lys  Val Leu Asp Asp Met  Asp Asp Asp Asp Asp  Leu Ser Thr 
    1265                 1270                 1275             


Asp Gly  Gly Ser Leu Tyr Glu  Ala Pro Val Ser Tyr  Thr Phe Ser 
    1280                 1285                 1290             


Lys Asp  Ser Thr Val Ala Ser  Gln Ile 
    1295                 1300         


<210>  582
<211>  4122
<212>  DNA
<213>  Homo Sapiens

<400>  582
gcgagcgaag ggagcgctct gggatgggac ttggagcaag cggcggcggc ggagacagag       60

gcagaggcag aagctggggc tccgtcctcg cctcccacga gcgatccccg aggagagccg      120

cggccctcgg cgaggcgaag aggccgacga ggaagacccg ggtggctgcg cccctgcctc      180

gcttcccagg cgccggcggc tgcagccttg cccctcttgc tcgccttgaa aatggaaaag      240

atgctcgcag gctgctttct gctgatcctc ggacagatcg tcctcctccc tgccgaggcc      300

agggagcggt cacgtgggag gtccatctct aggggcagac acgctcggac ccacccgcag      360

acggcccttc tggagagttc ctgtgagaac aagcgggcag acctggtttt catcattgac      420

agctctcgca gtgtcaacac ccatgactat gcaaaggtca aggagttcat cgtggacatc      480

ttgcaattct tggacattgg tcctgatgtc acccgagtgg gcctgctcca atatggcagc      540

actgtcaaga atgagttctc cctcaagacc ttcaagagga agtccgaggt ggagcgtgct      600

gtcaagagga tgcggcatct gtccacgggc accatgactg ggctggccat ccagtatgcc      660

ctgaacatcg cattctcaga agcagagggg gcccggcccc tgagggagaa tgtgccacgg      720

gtcataatga tcgtgacaga tgggagacct caggactccg tggccgaggt ggctgctaag      780

gcacgggaca cgggcatcct aatctttgcc attggtgtgg gccaggtaga cttcaacacc      840

ttgaagtcca ttgggagtga gccccatgag gaccatgtct tccttgtggc caatttcagc      900

cagattgaga cgctgacctc cgtgttccag aagaagttgt gcacggccca catgtgcagc      960

accctggagc ataactgtgc ccacttctgc atcaacatcc ctggctcata cgtctgcagg     1020

tgcaaacaag gctacattct caactcggat cagacgactt gcagaatcca ggatctgtgt     1080

gccatggagg accacaactg tgagcagctc tgtgtgaatg tgccgggctc cttcgtctgc     1140

cagtgctaca gtggctacgc cctggctgag gatgggaaga ggtgtgtggc tgtggactac     1200

tgtgcctcag aaaaccacgg atgtgaacat gagtgtgtaa atgctgatgg ctcctacctt     1260

tgccagtgcc atgaaggatt tgctcttaac ccagataaaa aaacgtgcac aaagatagac     1320

tactgtgcct catctaatca cggatgtcag cacgagtgtg ttaacacaga tgattcctat     1380

tcctgccact gcctgaaagg ctttaccctg aatccagata agaaaacctg cagaaggatc     1440

aactactgtg cactgaacaa accgggctgt gagcatgagt gcgtcaacat ggaggagagc     1500

tactactgcc gctgccaccg tggctacact ctggacccca atggcaaaac ctgcagccga     1560

gtggaccact gtgcacagca ggaccatggc tgtgagcagc tgtgtctgaa cacggaggat     1620

tccttcgtct gccagtgctc agaaggcttc ctcatcaacg aggacctcaa gacctgctcc     1680

cgggtggatt actgcctgct gagtgaccat ggttgtgaat actcctgtgt caacatggac     1740

agatcctttg cctgtcagtg tcctgaggga cacgtgctcc gcagcgatgg gaagacgtgt     1800

gcaaaattgg actcttgtgc tctgggggac cacggttgtg aacattcgtg tgtaagcagt     1860

gaagattcgt ttgtgtgcca gtgctttgaa ggttatatac tccgtgaaga tggaaaaacc     1920

tgcagaagga aagatgtctg ccaagctata gaccatggct gtgaacacat ttgtgtgaac     1980

agtgatgact catacacgtg cgagtgcttg gagggattcc ggctcgctga ggatgggaaa     2040

cgctgccgaa ggaaggatgt ctgcaaatca acccaccatg gctgcgaaca catttgtgtt     2100

aataatggga attcctacat ctgcaaatgc tcagagggat ttgttctagc tgaggacgga     2160

agacggtgca agaaatgcac tgaaggccca attgacctgg tctttgtgat cgatggatcc     2220

aagagtcttg gagaagagaa ttttgaggtc gtgaagcagt ttgtcactgg aattatagat     2280

tccttgacaa tttcccccaa agccgctcga gtggggctgc tccagtattc cacacaggtc     2340

cacacagagt tcactctgag aaacttcaac tcagccaaag acatgaaaaa agccgtggcc     2400

cacatgaaat acatgggaaa gggctctatg actgggctgg ccctgaaaca catgtttgag     2460

agaagtttta cccaaggaga aggggccagg cccctttcca caagggtgcc cagagcagcc     2520

attgtgttca ccgacggacg ggctcaggat gacgtctccg agtgggccag taaagccaag     2580

gccaatggta tcactatgta tgctgttggg gtaggaaaag ccattgagga ggaactacaa     2640

gagattgcct ctgagcccac aaacaagcat ctcttctatg ccgaagactt cagcacaatg     2700

gatgagataa gtgaaaaact caagaaaggc atctgtgaag ctctagaaga ctccgatgga     2760

agacaggact ctccagcagg ggaactgcca aaaacggtcc aacagccaac agaatctgag     2820

ccagtcacca taaatatcca agacctactt tcctgttcta attttgcagt gcaacacaga     2880

tatctgtttg aagaagacaa tcttttacgg tctacacaaa agctttccca ttcaacaaaa     2940

ccttcaggaa gccctttgga agaaaaacac gatcaatgca aatgtgaaaa ccttataatg     3000

ttccagaacc ttgcaaacga agaagtaaga aaattaacac agcgcttaga agaaatgaca     3060

cagagaatgg aagccctgga aaatcgcctg agatacagat gaagattaga aatcgcgaca     3120

catttgtagt cattgtatca cggattacaa tgaacgcagt gcagagcccc aaagctcagg     3180

ctattgttaa atcaataatg ttgtgaagta aaacaatcag tactgagaaa cctggtttgc     3240

cacagaacaa agacaagaag tatacactaa cttgtataaa tttatctagg aaaaaaatcc     3300

ttcagaattc taagatgaat ttaccaggtg agaatgaata agctatgcaa ggtattttgt     3360

aatatactgt ggacacaact tgcttctgcc tcatcctgcc ttagtgtgca atctcatttg     3420

actatacgat aaagtttgca cagtcttact tctgtagaac actggccata ggaaatgctg     3480

tttttttgta ctggacttta ccttgatata tgtatatgga tgtatgcata aaatcatagg     3540

acatatgtac ttgtggaaca agttggattt tttatacaat attaaaattc accacttcag     3600

agaatggtat tcagtgcaaa aattcttagt ttaactttaa atggaagata tgtatgtatg     3660

agaaatggcc aacatgccta tgaaaaaaat gctgaatctc atcagtaatc aggaaaatgc     3720

aggttaaaac aataccattt ttcacccatc agcttagcaa aaatgagtat attttttaac     3780

aagtgttggt aaggatgtgg aaatgtgagg ttcttgtagt aagaatgcaa atggcactct     3840

ttgtagagta agtctgttga catctcataa aactgaaaat gcacacaacc ctgtaaatct     3900

agcaactgca ctcagttgat ttcagcccat acatacaaag agacctgcat aagaatgtta     3960

ctaggctttg taaaagcaaa aaataaggaa caacttaaac atcatcagaa ggggaactga     4020

taaactctgg tgtaatccat accacagaaa tacaacaccg catgtacagg aatgtgctac     4080

atctatacaa ataaatggtc aaactcaaaa aaaaaaaaaa aa                        4122


<210>  583
<211>  956
<212>  PRT
<213>  Homo Sapiens

<400>  583

Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 
1               5                   10                  15      


Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 
            20                  25                  30          


Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 
        35                  40                  45              


Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 
    50                  55                  60                  


Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 
65                  70                  75                  80  


Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 
                85                  90                  95      


Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 
            100                 105                 110         


Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 
        115                 120                 125             


His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 
    130                 135                 140                 


Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 
145                 150                 155                 160 


Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 
                165                 170                 175     


Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 
            180                 185                 190         


Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 
        195                 200                 205             


Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 
    210                 215                 220                 


Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 
225                 230                 235                 240 


Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 
                245                 250                 255     


Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 
            260                 265                 270         


Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 
        275                 280                 285             


Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 
    290                 295                 300                 


Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 
305                 310                 315                 320 


Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 
                325                 330                 335     


Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 
            340                 345                 350         


Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 
        355                 360                 365             


Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 
    370                 375                 380                 


Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 
385                 390                 395                 400 


Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 
                405                 410                 415     


Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 
            420                 425                 430         


Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala 
        435                 440                 445             


Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser 
    450                 455                 460                 


Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys 
465                 470                 475                 480 


Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu 
                485                 490                 495     


Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu 
            500                 505                 510         


Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser 
        515                 520                 525             


Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu 
    530                 535                 540                 


Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp 
545                 550                 555                 560 


Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly 
                565                 570                 575     


Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys 
            580                 585                 590         


Leu Glu Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys 
        595                 600                 605             


Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn 
    610                 615                 620                 


Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala 
625                 630                 635                 640 


Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu 
                645                 650                 655     


Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu 
            660                 665                 670         


Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser 
        675                 680                 685             


Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His 
    690                 695                 700                 


Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys 
705                 710                 715                 720 


Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu 
                725                 730                 735     


Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala 
            740                 745                 750         


Arg Pro Leu Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp 
        755                 760                 765             


Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala 
    770                 775                 780                 


Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu 
785                 790                 795                 800 


Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr 
                805                 810                 815     


Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys 
            820                 825                 830         


Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro 
        835                 840                 845             


Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro 
    850                 855                 860                 


Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val 
865                 870                 875                 880 


Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln 
                885                 890                 895     


Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys 
            900                 905                 910         


His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala 
        915                 920                 925             


Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln 
    930                 935                 940                 


Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg 
945                 950                 955     


<210>  584
<211>  1973
<212>  DNA
<213>  Homo Sapiens

<400>  584
ctttgaaaaa gacttctttt gagctaactt tcttatactg gtacctttct aatctcacta       60

caatatgtaa cattggtgtt cgatctcaag tatttctgaa tatattcccc tatccacaga      120

aatatactct gggggaaaaa aaatagaaca aattcttgcc gtcctgacca ttgaacaaga      180

gactaattag acaatggggc tagaaaaacc tcaaagtaaa ctggaaggag gcatgcatcc      240

ccagctgata ccttcggtta ttgctgtagt tttcatctta cttctcagtg tctgttttat      300

tgcaagttgt ttggtgactc atcacaactt ttcacgctgt aagagaggca caggagtgca      360

caagttagag caccatgcaa agctcaaatg catcaaagag aaatcagaac tgaaaagtgc      420

tgaagggagc acctggaact gttgtcctat tgactggaga gccttccagt ccaactgcta      480

ttttcctctt actgacaaca agacgtgggc tgagagtgaa aggaactgtt cagggatggg      540

ggcccatctg atgaccatca gcacggaagc tgagcagaac tttattattc agtttctgga      600

tagacggctt tcctatttcc ttggacttag agatgagaat gccaaaggtc agtggcgttg      660

ggtggaccag acgccattta acccacgcag agtattctgg cataagaatg aacccgacaa      720

ctctcaggga gaaaactgtg ttgttcttgt ttataaccaa gataaatggg cctggaatga      780

tgttccttgt aactttgaag caagtaggat ttgtaaaata cctggaacaa cattgaacta      840

gaaactcaga aagtggtcct tgtgatggaa agagaaaaga aaaaccaatt agaataaggc      900

agaatgtacg tgcgtcattg gaacacagaa aacatgctgg ttcatacagc gtttttagtc      960

ataatggtct tttttatttt gtttgattca ttcgagacaa catgtgtgta tgtgtgtgtg     1020

tgtgtgtgta gataatgtgg tttttgtatg gtgtttgatg gaaggaataa tctttctttg     1080

ctttcttagt agtatttcaa ggtgtttact tttcaattgg tgtgcactga atgcatgtat     1140

ggaagaatag cgtgaataat gcaatctctt tgtcattttt ccccttctca gactcttagc     1200

tcttaaaatt caaagatggg atattctaac tggtagtggt gcatcatttt taacccaaat     1260

attgcaagca ctttaaagat ttgaaaccac atttttattg tttgatgttt cattttcaga     1320

ctttttaatg tcagtcatta caattacatt gcatgaggaa aatttttcca gaacaacagt     1380

gtggaatagt tctgaattat gctgttctac agatagaaaa aaagtccaaa tgcctttaaa     1440

aatttacttc ttactccacc caacacgttt ttgcaaagca agaagtcttt gtaagacacc     1500

ttaaacaaag tccttcaatt ctacagcaga ggaaataaaa tcccccagaa gccaaagggc     1560

tcaccttcac attgttagtt catgacagac ccaggtgtgc ttcattagag ataacataca     1620

ttccctttgg tatcacagga agttactggg gattactcga cctcattact tagctaacga     1680

ctggataaaa tttcttaatt gtttgaagta acattgtatt cgtgtttgca ttattaattt     1740

gaatagaaaa taatcacatt ttcaacccat ttatacaaat tgttaatgtt tctttagagc     1800

tgtataacta tagtttgaac tagcaaggaa gttattgttt tgacaaccag aaattatgct     1860

tttctggtgc atgaaacatt aattgcaaag ggcagtcaca tccaacttta ataaaatatg     1920

gtggtctttc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1973


<210>  585
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  585

Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Thr 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Thr 
145                 150                 155                 160 


Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn 
                165                 170                 175     


Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp 
            180                 185                 190         


Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys 
        195                 200                 205             


Ile Pro Gly Thr Thr Leu Asn 
    210                 215 


<210>  586
<211>  1181
<212>  DNA
<213>  Homo Sapiens

<400>  586
gcgcgcgcag gccggcgggg gcgcgccgcg ctgcgaggcc tgcgcgccag gctgcgggag       60

ccatgcggcg atcgaggagc tctgcggccg ccaagctgcg cgggcagaag cggtccgggg      120

cctccgcggc ccccgcggcc tccgcggccg ctgccttggc acccagcgcc acccgcacac      180

ggcgctccgc tagccaggcc gggagcaaga gccaggcggt ggagaagccg ccgtcggaga      240

agccgcggct gaggcgctcg tcgccgcggg cccaggagga gggcccgggg gagccgccgc      300

cgcctgagct ggcgttgctc ccgccaccgc cgccgccgcc gccgactccc gcgaccccga      360

cgtcctcggc gtccaacctg gacctgggcg agcagcggga gcgctgggag acgttccaga      420

agcggcagaa gcttacctcc gagggtgccg ccaagctcct gctagacacc tttgaatacc      480

agggcctggt gaagcacaca ggaggctgcc actgtggagc agttcgtttt gaagtttggg      540

cctcagcaga cttgcatata tttgactgca attgcagcat ttgcaagaag aagcagaata      600

gacacttcat tgttccagct tctcgcttca agctcctgaa gggagctgag cacataacga      660

cttacacgtt caatactcac aaagcccagc ataccttctg taagagatgt ggcgttcaga      720

gcttctatac tccacgatca aaccccggag gcttcggaat tgccccccac tgcctggatg      780

agggcactgt gcggagtatg gtcactgagg aattcaatgg cagcgattgg gagaaggcca      840

tgaaagagca caagaccatc aagaacatgt ctaaagagtg agcttctgcc tctcctgccc      900

tgaaaaggag gaatgattgg ggccagcaac tttgctctcc ctgccgtgcc tcggtggtgc      960

tcctgaatgt ggctgacctg ggctgctggt tccgttgact agggtcatct tgatctctgc     1020

agtttgctcc agctaccagt ttctttaggc agctctttgt cctccctctg cccagatttt     1080

gatgtagtct aattgacatc cttctcttcc caacttttgt gtgatctttt aggaaaaaaa     1140

ataaatattt ttaacattaa agcaaaaaaa aaaaaaaaaa a                         1181


<210>  587
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  587

Met Arg Arg Ser Arg Ser Ser Ala Ala Ala Lys Leu Arg Gly Gln Lys 
1               5                   10                  15      


Arg Ser Gly Ala Ser Ala Ala Pro Ala Ala Ser Ala Ala Ala Ala Leu 
            20                  25                  30          


Ala Pro Ser Ala Thr Arg Thr Arg Arg Ser Ala Ser Gln Ala Gly Ser 
        35                  40                  45              


Lys Ser Gln Ala Val Glu Lys Pro Pro Ser Glu Lys Pro Arg Leu Arg 
    50                  55                  60                  


Arg Ser Ser Pro Arg Ala Gln Glu Glu Gly Pro Gly Glu Pro Pro Pro 
65                  70                  75                  80  


Pro Glu Leu Ala Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro Thr Pro 
                85                  90                  95      


Ala Thr Pro Thr Ser Ser Ala Ser Asn Leu Asp Leu Gly Glu Gln Arg 
            100                 105                 110         


Glu Arg Trp Glu Thr Phe Gln Lys Arg Gln Lys Leu Thr Ser Glu Gly 
        115                 120                 125             


Ala Ala Lys Leu Leu Leu Asp Thr Phe Glu Tyr Gln Gly Leu Val Lys 
    130                 135                 140                 


His Thr Gly Gly Cys His Cys Gly Ala Val Arg Phe Glu Val Trp Ala 
145                 150                 155                 160 


Ser Ala Asp Leu His Ile Phe Asp Cys Asn Cys Ser Ile Cys Lys Lys 
                165                 170                 175     


Lys Gln Asn Arg His Phe Ile Val Pro Ala Ser Arg Phe Lys Leu Leu 
            180                 185                 190         


Lys Gly Ala Glu His Ile Thr Thr Tyr Thr Phe Asn Thr His Lys Ala 
        195                 200                 205             


Gln His Thr Phe Cys Lys Arg Cys Gly Val Gln Ser Phe Tyr Thr Pro 
    210                 215                 220                 


Arg Ser Asn Pro Gly Gly Phe Gly Ile Ala Pro His Cys Leu Asp Glu 
225                 230                 235                 240 


Gly Thr Val Arg Ser Met Val Thr Glu Glu Phe Asn Gly Ser Asp Trp 
                245                 250                 255     


Glu Lys Ala Met Lys Glu His Lys Thr Ile Lys Asn Met Ser Lys Glu 
            260                 265                 270         


<210>  588
<211>  1211
<212>  DNA
<213>  Homo Sapiens

<400>  588
ctgggctccg tgccgctctg tttgccaacc gtccagtccc gcctaccagt gccgggcgct       60

ccccacccct cccccggctc ccccggtgtc cgccatggcc aaagcctacg accacctctt      120

caagttgctg ctgatcgggg actcgggggt gggcaagact tgtctgatca ttcgctttgc      180

agaggacaac ttcaacaaca cttacatctc caccatcgga attgatttca agatccgcac      240

tgtggatata gaggggaaga agatcaaact acaagtctgg gacacggctg gccaagagcg      300

gttcaagaca ataactactg cctactaccg tggagccatg ggcattatcc tagtatacga      360

catcacggat gagaaatctt tcgagaatat tcagaactgg atgaaaagca tcaaggagaa      420

tgcctcggct ggggtggagc gcctcttgct ggggaacaaa tgtgacatgg aggccaagag      480

gaaggtgcag aaggagcagg ccgataagtt ggctcgagag catggaatcc gatttttcga      540

aactagtgct aaatccagta tgaatgtgga tgaggctttt agttccctgg cccgggacat      600

cttgctcaag tcaggaggcc ggagatcagg aaacggcaac aagcctccca gtactgacct      660

gaaaacttgt gacaagaaga acaccaacaa gtgctccctg ggctgaggac cctttcttgc      720

ctccccaccc cggaagctga acctgaggga gacaacggca gagggagtga gcaggggaga      780

aatagcagag gggcttggag ggtcacatag gtagatggta aagagaatga ggagaaaaag      840

gagaaaaggg aaaagcagaa aggaaaaaaa ggaagagaga ggaagggaga agggagagga      900

atgaattgag gaagtgaaag aaggcaagga ggtaggaaga gagggaggag gaaaggaagg      960

agagatgcct caggcttcag accttacctg ggttttcagg gcaaacataa atgtaaatac     1020

actgatttat tctgttacta gatcaggttt tagggtcctg caaaaggcta gctcggcact     1080

acactaggga atttgctcct gttctgtcac ttgtcatggt ctttcttggt attaaaggcc     1140

accatttgca caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa a                                                          1211


<210>  589
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  589

Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
            20                  25                  30          


Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe 
                85                  90                  95      


Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala 
            100                 105                 110         


Gly Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys 
        115                 120                 125             


Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly 
    130                 135                 140                 


Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu 
145                 150                 155                 160 


Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg 
                165                 170                 175     


Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys 
            180                 185                 190         


Asp Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
        195                 200             


<210>  590
<211>  1852
<212>  DNA
<213>  Homo Sapiens

<400>  590
caggagagaa ggcaccgccc ccaccccgcc tccaaagcta accctcgggc ttgaggggaa       60

gaggctgact gtacgttcct tctactctgg caccactctc caggctgcca tggggcccag      120

cacccctctc ctcatcttgt tccttttgtc atggtcggga cccctccaag gacagcagca      180

ccaccttgtg gagtacatgg aacgccgact agctgcttta gaggaacggc tggcccagtg      240

ccaggaccag agtagtcggc atgctgctga gctgcgggac ttcaagaaca agatgctgcc      300

actgctggag gtggcagaga aggagcggga ggcactcaga actgaggccg acaccatctc      360

cgggagagtg gatcgtctgg agcgggaggt agactatctg gagacccaga acccagctct      420

gccctgtgta gagtttgatg agaaggtgac tggaggccct gggaccaaag gcaagggaag      480

aaggaatgag aagtacgata tggtgacaga ctgtggctac acaatctctc aagtgagatc      540

aatgaagatt ctgaagcgat ttggtggccc agctggtcta tggaccaagg atccactggg      600

gcaaacagag aagatctacg tgttagatgg gacacagaat gacacagcct ttgtcttccc      660

aaggctgcgt gacttcaccc ttgccatggc tgcccggaaa gcttcccgag tccgggtgcc      720

cttcccctgg gtaggcacag ggcagctggt atatggtggc tttctttatt ttgctcggag      780

gcctcctgga agacctggtg gaggtggtga gatggagaac actttgcagc taatcaaatt      840

ccacctggca aaccgaacag tggtggacag ctcagtattc ccagcagagg ggctgatccc      900

cccctacggc ttgacagcag acacctacat cgacctggca gctgatgagg aaggtctttg      960

ggctgtctat gccacccggg aggatgacag gcacttgtgt ctggccaagt tagatccaca     1020

gacactggac acagagcagc agtgggacac accatgtccc agagagaatg ctgaggctgc     1080

ctttgtcatc tgtgggaccc tctatgtcgt ctataacacc cgtcctgcca gtcgggcccg     1140

catccagtgc tcctttgatg ccagcggcac cctgacccct gaacgggcag cactccctta     1200

ttttccccgc agatatggtg cccatgccag cctccgctat aacccccgag aacgccagct     1260

ctatgcctgg gatgatggct accagattgt ctataagctg gagatgagga agaaagagga     1320

ggaggtttga ggagctagcc ttgttttttg catctttctc actcccatac atttatatta     1380

tatccccact aaatttcttg ttcctcattc ttcaaatgtg ggccagttgt ggctcaaatc     1440

ctctatattt ttagccaatg gcaatcaaat tctttcagct cctttgtttc atacggaact     1500

ccagatcctg agtaatcctt ttagagcccg aagagtcaaa accctcaatg ttccctcctg     1560

ctctcctgcc ccatgtcaac aaatttcagg ctaaggatgc cccagaccca gggctctaac     1620

cttgtatgcg ggcaggccca gggagcaggc agcagtgttc ttcccctcag agtgacttgg     1680

ggagggagaa ataggaggag acgtccagct ctgtcctctc ttcctcactc ctcccttcag     1740

tgtcctgagg aacaggactt tctccacatt gttttgtatt gcaacatttt gcattaaaag     1800

gaaaatccac tgctaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1852


<210>  591
<211>  406
<212>  PRT
<213>  Homo Sapiens

<400>  591

Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 
1               5                   10                  15      


Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 
            20                  25                  30          


Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 
        35                  40                  45              


Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 
    50                  55                  60                  


Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 
65                  70                  75                  80  


Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 
                85                  90                  95      


Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 
            100                 105                 110         


Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 
        115                 120                 125             


Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser 
    130                 135                 140                 


Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys 
145                 150                 155                 160 


Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 
                165                 170                 175     


Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 
            180                 185                 190         


Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val 
        195                 200                 205             


Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg 
    210                 215                 220                 


Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln 
225                 230                 235                 240 


Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 
                245                 250                 255     


Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 
            260                 265                 270         


Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 
        275                 280                 285             


Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 
    290                 295                 300                 


Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 
305                 310                 315                 320 


Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 
                325                 330                 335     


Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 
            340                 345                 350         


Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg 
        355                 360                 365             


Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 
    370                 375                 380                 


Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg 
385                 390                 395                 400 


Lys Lys Glu Glu Glu Val 
                405     


<210>  592
<211>  1518
<212>  DNA
<213>  Homo Sapiens

<400>  592
cagagagaag aagaaatatt tccaaatata ccaggctgat ctttcgtagt ttctcagtct       60

tgctgtctgt tgttgtttga aatctgtttc ccacgagact ctgggaagat ggaggtgcag      120

ggcttgggta acagctgcct tcctcagggc tgggtacctg ctctccgagt ctgtgtctcc      180

aggctgtgtg ctcagacttg accatgtttg ggcatggagg cttgccccag atggggacca      240

aaagctgctt ccctggagac gggcggggag gccaaacttc ctgctgaagc tctgtggcct      300

cttttggggt gggggcgggg gtccaggcag aaagaaactg tctgctgctc aagacccaca      360

ggacgccggg aagactaaat gatcactgcc cccagtgaat atggtgaaga agctggtgat      420

ggcccagaag cggggagaga cacgagccct ttgcctgggt gtaaccatgg tggtgtgtgc      480

cgtcatcacc tactacatcc tggtcacgac tgtgctgccc ctctaccaga aaagcgtgtg      540

gacccaggaa tccaagtgcc acctgattga gaccaacatc agggaccagg aggagctgaa      600

gggcaagaag gtgccccagt acccatgcct gtgggtcaac gtgtcagctg ccggcaggtg      660

ggctgtgctg taccacacgg aggacactcg ggaccagaac cagcagtgct cctacatccc      720

aggcagcgtg gacaattacc agacggcccg ggccgacgtg gagaaggtca gagccaaatt      780

ccaagagcag caggtcttct actgcttctc cgcacctcgg gggaacgaaa ccagcgtcct      840

attccagcgc ctctacgggc cccaggccct cctcttctcc ctcttctggc ccaccttcct      900

gctgaccggt ggcctcctca ttatcgccat ggtgaagagc aaccagtacc tgtccatcct      960

ggcggcccag aagtagagcc atccatccat gccataccac ttgtcagggc acaggggact     1020

ggctgggccc ccagggctgc tccccacttg cagcacaatg ccttctccac ctgccctccc     1080

actcttccag tccaatccac gctgtcttct gttgcaggac taacctttga gaaatccttt     1140

tgtgaagtca ttgcctgctc aagaatgtac agtggctccc caatgccttg gaggccataa     1200

ggccagccag ttctagctct ctattacctg tccccactca actgactcat acctgtttcc     1260

ggctgcatca ctatgtgccc cacagagaac gatgatcgtc acctctgtgc ctgagttctc     1320

cctgttgtct caaagcggta cccatcctcc cccagaagct gtccccagcg agcctccctt     1380

ctttgtttga attctctaat aagagcaaca gcagctccca tttctagaac acatttacag     1440

tattactatt ttctaggata taaagtgcca tatatatttt taattccaat attaataaat     1500

gtatgccaaa caacaata                                                   1518


<210>  593
<211>  191
<212>  PRT
<213>  Homo Sapiens

<400>  593

Met Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
1               5                   10                  15      


Leu Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr 
            20                  25                  30          


Ile Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
        35                  40                  45              


Gln Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu 
    50                  55                  60                  


Glu Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
65                  70                  75                  80  


Val Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr 
                85                  90                  95      


Arg Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Gly Ser Val Asp Asn 
            100                 105                 110         


Tyr Gln Thr Ala Arg Ala Asp Val Glu Lys Val Arg Ala Lys Phe Gln 
        115                 120                 125             


Glu Gln Gln Val Phe Tyr Cys Phe Ser Ala Pro Arg Gly Asn Glu Thr 
    130                 135                 140                 


Ser Val Leu Phe Gln Arg Leu Tyr Gly Pro Gln Ala Leu Leu Phe Ser 
145                 150                 155                 160 


Leu Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala 
                165                 170                 175     


Met Val Lys Ser Asn Gln Tyr Leu Ser Ile Leu Ala Ala Gln Lys 
            180                 185                 190     


<210>  594
<211>  1334
<212>  DNA
<213>  Homo Sapiens

<400>  594
aatcattaga gcctgagtca ctctccccag gagacccaga cctagaacta cccagagcaa       60

gaccacagct ggtgaacagt ccaggagcag acaagatgga gacaaattcc tctctcccca      120

cgaacatctc tggagggaca cctgctgtat ctgctggcta tctcttcctg gatatcatca      180

cttatctggt atttgcagtc acctttgtcc tcggggtcct gggcaacggg cttgtgatct      240

gggtggctgg attccggatg acacacacag tcaccaccat cagttacctg aacctggccg      300

tggctgactt ctgtttcacc tccactttgc cattcttcat ggtcaggaag gccatgggag      360

gacattggcc tttcggctgg ttcctgtgca aattcgtctt taccatagtg gacatcaact      420

tgttcggaag tgtcttcctg atcgccctca ttgctctgga ccgctgtgtt tgcgtcctgc      480

atccagtctg gacccagaac caccgcaccg tgagcctggc caagaaggtg atcattgggc      540

cctgggtgat ggctctgctc ctcacattgc cagttatcat tcgtgtgact acagtacctg      600

gtaaaacggg gacagtagcc tgcactttta acttttcgcc ctggaccaac gaccctaaag      660

agaggataaa tgtggccgtt gccatgttga cggtgagagg catcatccgg ttcatcattg      720

gcttcagcgc acccatgtcc atcgttgctg tcagttatgg gcttattgcc accaagatcc      780

acaagcaagg cttgattaag tccagtcgtc ccttacgggt cctctccttt gtcgcagcag      840

ccttttttct ctgctggtcc ccatatcagg tggtggccct tatagccaca gtcagaatcc      900

gtgagttatt gcaaggcatg tacaaagaaa ttggtattgc agtggatgtg acaagtgccc      960

tggccttctt caacagctgc ctcaacccca tgctctatgt cttcatgggc caggacttcc     1020

gggagaggct gatccacgcc cttcccgcca gtctggagag ggccctgacc gaggactcaa     1080

cccaaaccag tgacacagct accaattcta ctttaccttc tgcagaggtg gagttacagg     1140

caaagtgagg agggagctgg gggacacttt cgagctccca gctccagctt cgtctcacct     1200

tgagttaggc tgagccacag gcatttcctg cttattttag gattacccac tcatcagaaa     1260

aaaaaaaaaa agcctttgtg tcccctgatt tggggagaat aaacagatat gagtttaaaa     1320

aaaaaaaaaa aaaa                                                       1334


<210>  595
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  595

Met Glu Thr Asn Ser Ser Leu Pro Thr Asn Ile Ser Gly Gly Thr Pro 
1               5                   10                  15      


Ala Val Ser Ala Gly Tyr Leu Phe Leu Asp Ile Ile Thr Tyr Leu Val 
            20                  25                  30          


Phe Ala Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr His Thr Val Thr Thr Ile Ser Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Val Ala Asp Phe Cys Phe Thr Ser Thr Leu Pro Phe 
65                  70                  75                  80  


Phe Met Val Arg Lys Ala Met Gly Gly His Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Phe Val Phe Thr Ile Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Ala Leu Ile Ala Leu Asp Arg Cys Val Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Thr Gln Asn His Arg Thr Val Ser Leu Ala Lys Lys 
    130                 135                 140                 


Val Ile Ile Gly Pro Trp Val Met Ala Leu Leu Leu Thr Leu Pro Val 
145                 150                 155                 160 


Ile Ile Arg Val Thr Thr Val Pro Gly Lys Thr Gly Thr Val Ala Cys 
                165                 170                 175     


Thr Phe Asn Phe Ser Pro Trp Thr Asn Asp Pro Lys Glu Arg Ile Asn 
            180                 185                 190         


Val Ala Val Ala Met Leu Thr Val Arg Gly Ile Ile Arg Phe Ile Ile 
        195                 200                 205             


Gly Phe Ser Ala Pro Met Ser Ile Val Ala Val Ser Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Thr Lys Ile His Lys Gln Gly Leu Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Ser Phe Val Ala Ala Ala Phe Phe Leu Cys Trp Ser Pro 
                245                 250                 255     


Tyr Gln Val Val Ala Leu Ile Ala Thr Val Arg Ile Arg Glu Leu Leu 
            260                 265                 270         


Gln Gly Met Tyr Lys Glu Ile Gly Ile Ala Val Asp Val Thr Ser Ala 
        275                 280                 285             


Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe Met 
    290                 295                 300                 


Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ala Leu Pro Ala Ser Leu 
305                 310                 315                 320 


Glu Arg Ala Leu Thr Glu Asp Ser Thr Gln Thr Ser Asp Thr Ala Thr 
                325                 330                 335     


Asn Ser Thr Leu Pro Ser Ala Glu Val Glu Leu Gln Ala Lys 
            340                 345                 350 


<210>  596
<211>  18090
<212>  DNA
<213>  Homo Sapiens

<400>  596
gtcgagtcgc cctcgcctcg cccgcaccat gatcgccgcg gctttcctcg tcttgctgag       60

accctacagc atccaatgtg ccctcttcct cttgttgctt ctgctgggca ccatcgccac      120

catcgtcttc ttctgctgct ggcaccgcaa gctccagaaa gggaggcatc cgatgaaatc      180

ggtcttctcg ggtcgttcaa gaagccgaga tgctgttttg agatcgcacc actttcgttc      240

tgagggattc agagcaagcc ctcggcatct tagaagacga gttgcagcgg ccgcagctgc      300

ccgtctggaa gaagtgaagc ccgtggtgga agttcaccat cagagtgagc aagaaacttc      360

agtgaggaaa cgaagaatca agaagagcag ccgagtccag ccagaatttt atcactctgt      420

tcaaggtgct tcaatcagga ggcctagttc cgggaacgcg tcctatcgct gctctatgtc      480

ttcctctgcg gatttttccg atgaggatga tttcagccag aaatctggct ccgcatcccc      540

agctccggga gacaccttac cctggaattt gcctaaacat gagagatcga aaagaaagat      600

tcaagggggc tcagtgctgg accctgccga gagggcagtg cttcggatag cagatgaacg      660

ggacaaagtt cagaagaaaa catttacaaa atggataaat cagcatctca tgaaggttcg      720

aaaacatgtg aatgatctct atgaagactt aagggatgga cacaatttga tttctctttt      780

agaggttctt tcaggagata ccttgcccag agaaaaaggt cggatgcgtt ttcacagact      840

acagaatgta caaattgcac ttgactattt gaaaagacgc caggtgaaat tagtgaatat      900

tagaaatgat gacataacag atggaaatcc caaattgact ttgggattaa tctggacaat      960

aattttgcac tttcagatat ctgatatcca tgttactgga gagtcagagg atatgtctgc     1020

aaaagagaga ttgctactct ggacgcagca ggcaacagag ggttatgctg gaattcggtg     1080

tgaaaatttc actacctgct ggagagatgg aaaattattt aatgccatca ttcataaata     1140

caggccggac ctgatagata tgaatactgt tgctgttcaa agcaaccttg caaatttaga     1200

gcatgctttt tacgtagcag aaaaaattgg tgttataaga cttctggacc ctgaagatgt     1260

cgatgtctcc tcacctgatg aaaaatcagt aataacttac gtgtcatctc tctatgatgc     1320

atttcctaaa gtccctgaag gtggggaagg cattggtgca aatgatgttg aagtcaaatg     1380

gattgaatac cagaatatgg tgaactacct catccaatgg attagacacc atgtgaccac     1440

aatgtctgag agaacatttc ctaataatcc tgtagaactg aaggcacttt ataatcagta     1500

tttacagttt aaagaaacag aaattccacc aaaggagaca gaaaaatcaa aaattaaacg     1560

tctatataaa ttattagaga tttggataga atttggacgc atcaagctcc ttcaaggtta     1620

tcatccaaat gacatagaaa aagagtgggg gaaactcatt attgccatgc tagagagaga     1680

gaaggccctt cgtccagaag tagaaaggtt agaaatgttg caacagattg ccaacagagt     1740

tcagagggac agtgtcatct gtgaagacaa actgattctt gctggaaatg ctcttcagtc     1800

tgattctaaa agattagaat caggagtgca gtttcagaat gaagcagaaa ttgctgggta     1860

tatacttgaa tgtgagaacc ttttacgcca gcatgtaatt gatgtacaga ttcttattga     1920

tggaaaatac taccaggcag atcaattggt acagagggtt gcaaaactgc gtgacgaaat     1980

tatggcctta aggaacgaat gttcttctgt gtacagcaaa ggacgcatac tgacaacaga     2040

acagacaaag ctcatgatat caggaatcac tcaaagttta aactcaggat ttgcacagac     2100

cttacaccct agtctgacct cagggctgac ccagagttta acaccttccc taacctcttc     2160

tagtatgact tctggcctgt catcagggat gacttcccgc ctgactccat ctgtcactcc     2220

agcttataca cctggtttcc catcaggatt agttccaaat ttcagttcag gagtagagcc     2280

aaattcattg caaactttga agttgatgca gatccgaaaa ccccttctaa agtcttcttt     2340

gctggatcaa aatttaacag aagaagaaat caatatgaaa tttgttcagg atcttttgaa     2400

ttgggttgat gagatgcagg tacaactgga ccgcactgag tggggctcag atttgccaag     2460

tgttgaaagc catttagaaa atcataaaaa tgttcataga gctattgaag aatttgaatc     2520

tagtctcaaa gaagctaaaa tcagtgagat tcaaatgaca gcacctctta aactgactta     2580

tgcagaaaag ttgcacagat tagagagtca gtatgcaaaa ctcttgaata catccaggaa     2640

tcaagaacgg caccttgata cactccataa ttttgtaagt cgtgcgacta atgaacttat     2700

ttggttgaat gaaaaagaag aggaggaagt tgcttatgac tggagtgaga gaaacaccaa     2760

catagctagg aaaaaagatt atcatgctga attaatgaga gaacttgatc aaaaggaaga     2820

aaatattaaa tcagttcagg agatagcaga gcagctactt ctagaaaatc atccagcccg     2880

gttaactatt gaggcctaca gagcggcaat gcagacgcag tggagctgga tcttacagct     2940

ctgccagtgt gtggagcagc acataaagga gaacacagcg tatttcgagt ttttcaatga     3000

tgccaaagaa gctactgatt acttaaggaa tctaaaagat gccattcagc ggaagtacag     3060

ctgtgataga tcaagcagca ttcacaagct agaagacctt gttcaggaat caatggaaga     3120

gaaagaagaa cttctgcagt acaaaagcac tatagcaaac ctaatgggaa aagcaaaaac     3180

aataattcaa ctgaagccaa ggaattctga ctgtccactc aaaacttcta ttccgatcaa     3240

agctatctgt gactacagac aaattgagat aaccatttac aaagacgatg aatgtgtttt     3300

ggcgaataac tctcatcgtg ctaaatggaa ggtcattagt cctactggga atgaggctat     3360

ggtcccatct gtgtgcttca ccgttcctcc accaaacaaa gaagcggtgg accttgccaa     3420

cagaattgag caacagtatc agaatgtcct gactctttgg catgagtctc acataaacat     3480

gaagagtgta gtatcctggc attatctcat caatgaaatt gatagaattc gagctagcaa     3540

tgtggcttca ataaagacaa tgctacctgg tgaacatcag caagttctaa gtaatctaca     3600

atctcgtttt gaagattttc tggaagatag ccaggaatcc caagtctttt caggctcaga     3660

tataacacaa ctggaaaagg aggttaatgt atgtaagcag tattatcaag aacttcttaa     3720

atctgcagaa agagaggagc aagaggaatc agtttataat ctctacatct ctgaagttcg     3780

aaacattaga cttcggttag agaactgtga agatcggctg attagacaga ttcgaactcc     3840

cctggaaaga gatgatttgc atgaaagtgt gttcagaatc acagaacagg agaaactaaa     3900

gaaagagctg gaacgactta aagatgattt gggaacaatc acaaataagt gtgaggagtt     3960

tttcagtcaa gcagcagcct cttcatcagt ccctacccta cgatcagagc ttaatgtggt     4020

ccttcagaac atgaaccaag tctattctat gtcttccact tacatagata agttgaaaac     4080

tgttaacttg gtgttaaaaa acactcaagc tgcagaagcc ctcgtaaaac tctatgaaac     4140

taaactgtgt gaagaagaag cagttatagc tgacaagaat aatattgaga atctaataag     4200

tactttaaag caatggagat ctgaagtaga tgaaaagaga caggtattcc atgccttaga     4260

ggatgagttg cagaaagcta aagccatcag tgatgaaatg tttaaaacgt ataaagaacg     4320

ggaccttgat tttgactggc acaaagaaaa agcagatcaa ttagttgaaa ggtggcaaaa     4380

tgttcatgtg cagattgaca acaggttacg ggacttagag ggcattggca aatcactgaa     4440

gtactacaga gacacttacc atcctttaga tgattggatc cagcaggttg aaactactca     4500

gagaaagatt caggaaaatc agcctgaaaa tagtaaaacc ctagccacac agttgaatca     4560

acagaagatg ctggtgtccg aaatagaaat gaaacagagc aaaatggacg agtgtcaaaa     4620

atatgcagaa cagtactcag ctacagtgaa ggactatgaa ttacaaacaa tgacctaccg     4680

ggccatggta gattcacaac aaaaatctcc agtgaaacgc cgaagaatgc agagttcagc     4740

agatctcatt attcaagagt tcatggacct aaggactcga tatactgccc tggtcactct     4800

catgacacaa tatattaaat ttgctggtga ttcattgaag aggctggaag aggaggagaa     4860

gtcactggaa gaagaaaaga aagaacatgt tgaaaaagcc aaagaattgc aaaaatgggt     4920

atcaaatatc agcaagacat tgaaagatgc agagaaggct ggaaaacctc ccttctctaa     4980

gcaaaagatt tccagtgagg aaatatcaac caagaaggaa caattatcgg aagcacttca     5040

aactatacag ctttttttgg caaaacatgg agacaaaatg acagatgaag aaagaaatga     5100

attggaaaaa caagtgaaaa ctcttcagga aagttataat ttattattca gtgaatctct     5160

gaaacagcta caagaatcac aaacctcagg agatgtaaag gtagaggaga agattgtagc     5220

agagcgtcag caggagtata aagagaaact ccaagggata tgtgatcttc ttacccaaac     5280

tgaaaaccgc ctaattggtc accaagaagc cttcatgatt ggagatggca cagttgagtt     5340

aaagaaatat cagtccaagc aagaggaatt acagaaagat atgcaaggaa gtgcacaggc     5400

attggctgaa gtagtgaaaa acacagagaa cttcttaaaa gagaatggtg aaaagctgtc     5460

acaggaagat aaggctttga ttgaacagaa acttaatgaa gctaagataa agtgtgaaca     5520

gcttaattta aaagcagaac agtctaaaaa ggagctggat aaagttgtga caacagcaat     5580

caaggaagaa actgaaaagg tagcagcagt gaagcagctg gaagagagca aaaccaaaat     5640

agaaaacctt ttggactggt tgtcaaatgt tgacaaagac tcagaaaggg cagggacaaa     5700

acacaaacag gtaatcgaac agaacgggac ccattttcaa gaaggtgatg gcaagtcagc     5760

aattggagaa gaggatgaag ttaatggtaa cctgttggag actgatgttg atgggcaagt     5820

tggaaccact caggagaatc tgaatcagca atatcagaaa gttaaggccc aacacgagaa     5880

gatcatctct cagcaccaag cagtgatcat agccactcag tctgcacaag tgttgcttga     5940

gaaacagggt cagtatctct ctcctgaaga aaaagagaaa ctgcaaaaga acatgaagga     6000

actgaaagtg cattatgaaa ctgcactggc tgagtcagag aagaaaatga agttaactca     6060

ctctctgcag gaagaattag aaaagtttga tgctgactat accgagtttg agcactggct     6120

acagcagtca gaacaagaac ttgaaaacct ggaggcaggt gcagatgaca tcaatggttt     6180

aatgaccaaa ttgaagaggc agaagagttt ctcagaagac gttatttctc acaaaggtga     6240

cttgagatac atcacaattt ctggaaacag agtgttggaa gctgccaaat cttgcagcaa     6300

gagagacggt ggcaaggttg atacttctgc aacccacaga gaagtgcagc gcaagttgga     6360

tcatgctact gatcggttca ggtctctcta ctctaagtgc aatgttcttg gaaataatct     6420

taaagatctg gtggataaat atcaacacta tgaagatgct tcatgtggac ttcttgctgg     6480

actccaggcc tgtgaggcca cagcgagcaa acacttatct gaacctattg cggtggaccc     6540

caaaaatctt caaaggcaat tagaagagac caaggctttg caaggacaga tatcaagtca     6600

gcaggttgct gtagagaaac tgaagaaaac ggctgaagtg cttttagatg ccaggggatc     6660

tttacttcca gccaagaatg atatccagaa aacacttgat gacattgttg ggagatatga     6720

ggatctgtcc aagtctgtta atgaacgaaa tgaaaaactc cagataacct tgacccgttc     6780

actgagtgtg caggatggct tggatgaaat gctggactgg atgggaaatg tggaaagttc     6840

tctgaaagaa caaggtcaag tgcctttaaa ctctactgct cttcaggata ttatcagtaa     6900

aaacattatg ttggaacagg atattgcagg tcgtcagagc agtataaatg ccatgaatga     6960

aaaagtgaag aaatttatgg aaacaacaga tccatccact gcatcctcac tgcaagccaa     7020

aatgaaagac ttgtctgctc ggttttcaga agcaagtcat aaacacaaag aaactcttgc     7080

caaaatggag gagctaaaaa ccaaagtaga actgtttgag aacctctcag aaaagctcca     7140

gacattttta gaaacaaaaa ctcaggctct tactgaagta gatgtgccag gaaaagatgt     7200

tactgaattg tctcagtata tgcaggaatc aacttctgaa tttttagaac acaagaaaca     7260

tcttgaagtt ttgcatagtc tcttgaagga gatatccagc catggcttac caagtgataa     7320

ggctttggtc cttgaaaaaa caaataattt gtcaaagaaa ttcaaggaaa tggaggatac     7380

catcaaagaa aaaaaagaag ctgtaacttc ttgtcaagaa cagttggatg ctttccaagt     7440

tcttgttaaa tcattgaagt catggataaa agaaacaaca aaaaaagttc ccattgtaca     7500

gccttctttt ggtgcagagg atttaggaaa atctttggaa gacactaaga aattacaaga     7560

aaagtggagt ttaaaaacac cagagattca gaaagtaaac aacagtggga tctcactatg     7620

taacttaata agtgctgtga ccacccctgc aaaggcaata gcagcagtta aatcaggtgg     7680

agcagtatta aatggtgaag gaacagccac aaatactgag gaattttggg caaataaagg     7740

tttaacatcc attaaaaagg acatgactga cataagtcat ggttatgaag atcttggcct     7800

cttactcaag gacaaaatag cggaactgaa cactaaactc tccaaattgc aaaaggctca     7860

ggaagaatca agtgcaatga tgcagtggtt acagaaaatg aacaaaactg caacaaaatg     7920

gcagcagaca cctgcaccta cagatactga agctgtgaag actcaagttg agcagaataa     7980

gtcgtttgag gcagaactga agcagaatgt aaacaaagta caggagttga aagacaaatt     8040

gacagagctg ttggaggaga acccagatac tcctgaggcc cccagatgga aacagatgtt     8100

gacagaaata gattctaagt ggcaagaact caatcaatta acaattgata gacaacaaaa     8160

actggaagaa tcctccaata atctaaccca gttccagact gtagaggccc aattgaaaca     8220

gtggcttgtg gaaaaagaac ttatggtcag tgttcttggg cccttgtcaa ttgacccaaa     8280

tatgctaaac acacaaaggc agcaggtgca gattttgctg caagaattcg ccactcggaa     8340

acctcaatat gaacagctga cagcagctgg tcagggcatt ctgagcaggc ctggagaaga     8400

cccttcttta cgtgggattg tgaaagagca actggcagct gtgacccaaa aatgggatag     8460

cctaacaggg caattgagtg acagatgtga ctggattgac caagccattg ttaaaagcac     8520

acagtatcaa agcctgctga gaagcctttc tgataaactg agtgacttgg ataataaact     8580

cagcagcagt ctggctgtga gcacgcaccc tgatgctatg aaccaacagt tggaaacagc     8640

ccaaaaaatg aagcaggaga tacagcagga aaagaagcag ataaaagtgg cccaggcact     8700

ctgtgaggat ttgtcagcac tggttaaaga agagtacttg aaagcagaac ttagtaggca     8760

actagaaggc atcttaaaat catttaagga tgttgaacag aaagcagaga atcatgtcca     8820

gcaccttcag tcggcctgtg caagctctca tcaatttcag caaatgtcta gagattttca     8880

ggcttggctg gatacaaaga aagaagagca aaacaaatct catccaatat ctgccaaact     8940

cgatgtcttg gagtcattaa ttaaagatca taaagacttt agtaaaactt tgaccgctca     9000

gtctcatatg tatgaaaaaa ccattgcaga aggtgaaaat ctgttattaa aaacacaagg     9060

gtctgagaag gcagccttac agttacagct taatacaatt aaaaccaatt gggatacatt     9120

taataagcag gtgaaagaaa gagaaaacaa gttaaaagag tcattggaaa aagcccttaa     9180

gtataaagag caagtagaga ctctctggcc atggatagac aaatgccaaa acaacctgga     9240

ggaaataaaa ttttgcttgg atcctgctga aggagagaat tctattgcca agttaaagtc     9300

tctgcagaag gaaatggacc aacactttgg tatggtagaa ttactgaaca acacagccaa     9360

tagcttgctc agtgtctgtg agatagataa agaagttgtt acagatgaga ataagtcact     9420

gatccagaag gtggacatgg tcactgaaca acttcacagt aagaaattct gtctggagaa     9480

catgactcag aagtttaaag aatttcaaga agtttccaaa gaatctaaaa ggcagcttca     9540

gtgtgcaaag gagcagctag atatccatga ttcgctggga tcccaggctt acagtaacaa     9600

atacctgacc atgttgcaaa ctcagcagaa atcacttcag gccttgaagc atcaggtaga     9660

tttggctaaa agacttgcac aggaccttgt ggtagaggcc tcagactcaa agggaacctc     9720

tgatgtttta ttacaagtgg aaaccatagc tcaagagcat agtacactaa gtcagcaggt     9780

tgatgaaaag tgttctttct tagaaaccaa gcttcagggc attgggcatt tccagaatac     9840

cattcgagaa atgttttctc agttcgcaga gtttgatgat gaactggata gcatggctcc     9900

agtggggaga gatgcagaaa cattgcaaaa gcaaaaggaa actataaaag cctttctaaa     9960

gaaactagaa gccctcatgg caagcaatga caatgccaat aaaacctgca agatgatgtt    10020

agccacagaa gaaacctctc ctgaccttgt tggaatcaaa agggacttgg aggccttaag    10080

caaacaatgc aacaagttac tggaccgagc ccaagccaga gaagagcagg ttgaagggac    10140

aattaagcgc cttgaagaat tttacagcaa attgaaagaa ttttctattc tgctccagaa    10200

agccgaagaa catgaagagt cacaaggtcc tgttggtatg gaaacggaga caattaatca    10260

gcagcttaac atgttcaagg tattccagaa agaagagatt gaacccttgc aaggtaaaca    10320

gcaagatgta aactggttag gtcaaggcct tattcagagt gctgccaaaa gcactagcac    10380

tcagggcttg gagcatgacc tggatgatgt caatgcacgg tggaagactc tcaataagaa    10440

ggtggctcag cgagcagccc agctgcagga ggccttgctg cactgtggga ggttccagga    10500

tgccctggag tccctgctca gctggatggt ggacactgag gagcttgtgg ccaatcagaa    10560

gcccccgtcg gctgagttca aagtggtaaa ggcccagata caagaacaaa agcttctcca    10620

gagattgttg gatgaccgaa aatctacggt ggaggtaatc aaacgagaag gagaaaaaat    10680

tgctacaaca gcagagcccg cagataaagt gaagattttg aaacagctca gtctcttgga    10740

tagcagatgg gaggcattgc ttaataaagc tgaaacaagg aatcgtcagt tggaaggtat    10800

ctcggtggta gcacagcaat ttcatgaaac cttagaacca ctgaacgagt ggcttacaac    10860

catagaaaag aggctggtga attgtgaacc cataggaacc caagcatcta aacttgagga    10920

acaaattgca cagcacaaag ccttagaaga tgacatcatc aatcacaata aacatttaca    10980

ccaggctgtt agcattggcc agtccttaaa ggttttgagc tccagggagg ataaagatat    11040

ggtgcagagt aaattagact tctctcaagt atggtacatt gagattcaag agaaaagtca    11100

cagcaggtct gagctcctcc agcaggcctt atgtaatgct aagatttttg gggaagatga    11160

agttgaactg atgaactggc tgaatgaagt gcatgacaaa ctgagcaagc tctcagtcca    11220

ggattacagc actgaggggc tatggaagca gcagtctgaa cttcgggttc tgcaagagga    11280

catcttactc aggaaacaaa atgtagatca ggctttacta aatggtttag aactacttaa    11340

acaaaccaca ggtgatgaag ttttaataat tcaagataaa ttggaagcca ttaaagcaag    11400

gtacaaagac attactaaac tgagcactga tgtggccaag actctggaac aggcgctgca    11460

gcttgcaagg cggctgcact ccacacacga agagctgtgt acctggctgg acaaagtgga    11520

ggtggaatta ctttcatatg aaactcaggt tctgaaagga gaagaagcaa gtcaagcaca    11580

aatgagacca aaggaactga aaaaggaagc taagaacaac aaagccttac tggactccct    11640

taatgaagtg agcagtgctt tgctggaact ggtaccatgg agggcaagag aaggacttga    11700

gaaaatggta gctgaggaca atgagcgcta ccgattagtg agcgacacca tcactcagaa    11760

ggtggaggag atcgatgcag ccattctgcg atcacagcag tttgaccaag cagctgatgc    11820

tgagttatcc tggattactg aaacagaaaa aaaattgatg tctctgggtg acatcaggct    11880

tgagcaagac cagacttctg ctcagcttca agttcaaaag acattcacca tggagatttt    11940

gagacacaag gatattattg atgaccttgt taaatctggg cataaaatca tgaccgcatg    12000

cagtgaagag gaaaagcaat caatgaagaa aaaactggac aaggtactga agaactatga    12060

taccatctgc cagattaatt cagaaaggta tctgcagctg gaacgggcac agtccctggt    12120

taaccaattc tgggaaacat atgaagaact ttggccatgg ctgacagaaa cacaatcaat    12180

catctctcag cttcccgccc cagcccttga atatgaaact ctaaggcagc agcaggaaga    12240

acatcggcaa ctgcgtgagt tgatagctga acacaagcct catatagata agatgaacaa    12300

aactgggcca cagttactgg aattgagccc tggggaaggc ttttctatcc aagagaagta    12360

tgtggcagcc gacacccttt acagtcaaat taaagaagat gtcaaaaagc gtgctgtggc    12420

actggatgaa gccatttctc aatcaactca gttccatgac aagatagatc agatccttga    12480

gagcctggaa cgcatcgtgg aacgtctgag gcagccaccc tctatctctg cagaggttga    12540

gaagatcaag gaacagatca gtgaaaataa gaatgtgtca gtagacatgg aaaagctaca    12600

gccgttgtat gaaactctta aacagagggg agaggaaatg attgctagat ctggggggac    12660

tgataaagac atatctgcca aagctgttca ggataagctt gaccaaatgg ttttcatttg    12720

ggagaacata cacacactgg tggaagagag ggaagccaaa ctactggatg tgatggagct    12780

agcagaaaag ttctggtgtg atcacatgtc attgatagtt accattaaag atactcaaga    12840

tttcatccgg gacctggaag atcctggaat tgatccttca gtagtaaaac aacagcaaga    12900

agcagcagag accataaggg aagaaataga tggactacag gaggagctgg atatagttat    12960

taacctaggt tctgaactca ttgcggcatg tggggagcct gataaaccca ttgtcaagaa    13020

gagtatagat gagttaaatt cagcatggga ttctctaaat aaagcttgga aagaccggat    13080

tgacaaactt gaggaggcaa tgcaggctgc cgttcagtac caggatggac tgcaggcggt    13140

atttgactgg gtagatattg caggtggtaa attagcttca atgtctccaa ttggaacaga    13200

tctcgaaact gtcaagcagc agattgaaga gctaaagcaa tttaagtctg aggcctatca    13260

acagcagata gaaatggaaa gactgaatca tcaagcagag cttttgctaa agaaagtaac    13320

agaagagagt gacaaacaca ctgttcaaga cccattaatg gaactgaaat tgatatggga    13380

tagcctggag gagagaatca tcaacagaca gcataaactg gagggtgctc tattagcctt    13440

gggtcagttc caacatgccc tggatgagct cctggcatgg ctgacacaca ccgagggctt    13500

gctaagtgag cagaaacctg ttggaggaga ccctaaagcc attgaaattg aacttgccaa    13560

gcatcatgtg ctccaaaatg atgtattagc ccatcagtcc acagtggaag ccgttaataa    13620

agcaggaaat gatctaattg aatcaagtgc aggagaagaa gcaagcaacc ttcagaacaa    13680

gctagaggtt ttaaatcaac gctggcaaaa tgttttggaa aaaacagaac aaaggaagca    13740

gcagctggat ggtgccttgc gccaggccaa agggttccat ggcgaaattg aggatttgca    13800

gcagtggctg actgacacgg agcgtcatct gttggcatct aaaccgctgg gaggtttacc    13860

ggaaacagcc aaggagcagc ttaatgtcca tatggaagtc tgtgctgcct ttgaagctaa    13920

agaagaaaca tataagagtc tgatgcagaa aggccagcag atgcttgcaa gatgcccaaa    13980

atctgcagag acaaatattg accaagacat aaataacttg aaagaaaaat gggaatcggt    14040

ggaaaccaaa ctcaatgaaa ggaaaactaa actggaagag gctctcaact tggcaatgga    14100

gttccacaat tctctccaag acttcatcaa ctggcttact caggctgaac agaccctaaa    14160

tgtagcttct cggccaagtc tcatcttgga cacagtctta tttcaaattg acgaacacaa    14220

ggtttttgcc aatgaagtaa attctcatcg tgagcagata atagagctgg acaaaactgg    14280

aacccaccta aaatatttta gtcagaaaca agatgttgtt ctaatcaaga atctacttat    14340

cagtgtacaa agtcgatggg aaaaagtggt tcaacggttg gtagagagag gaagatcttt    14400

ggatgatgca aggaagagag ccaagcagtt ccatgaagct tggagtaaac ttatggagtg    14460

gctagaagag tcagaaaagt ctttggattc tgaactggaa atcgcaaatg atccagacaa    14520

aataaaaaca caacttgcac aacataagga gtttcagaaa tcactcggag ccaagcattc    14580

tgtctacgac accaccaaca ggactggacg ttctctgaag gagaaaacct ccctggctga    14640

tgacaacctg aaactggatg acatgctgag tgaactcaga gacaaatggg ataccatatg    14700

tggaaaatct gtggaaagac aaaacaaatt ggaggaagcc ctgttatttt ctggacaatt    14760

cacagatgcc ctacaggctc tcattgattg gttatataga gttgaacccc agctggcaga    14820

agaccagcct gttcatggag acattgattt ggtgatgaat ctgatcgata atcacaaggc    14880

cttccaaaaa gagttgggga agaggaccag cagtgtgcag gccctgaagc gctcagcccg    14940

agaactcata gaaggcagtc gggatgactc ctcctgggtc aaggtccaga tgcaggaatt    15000

aagcacacgc tgggagaccg tgtgtgcact ttctatatca aagcaaacac ggttagaagc    15060

agccctgcgt caggcagagg aattccactc ggtggtacat gccctcttgg agtggctggc    15120

tgaggcggag caaaccctgc gtttccatgg tgtcctccca gatgatgagg atgctctccg    15180

gactctcatt gatcagcata aagaattcat gaagaaactg gaagaaaaga gagctgaact    15240

aaataaagcc accactatgg gcgacaccgt tttggctatc tgccaccccg actccatcac    15300

taccattaag cactggataa caatcatccg ggcgaggttt gaggaggtgc tggcctgggc    15360

aaagcaacat cagcagagat tagcaagtgc tctggctggg cttattgcca aacaggaatt    15420

gttggaagct ttgctggctt ggttgcaatg ggctgaaact acacttactg ataaggataa    15480

agaagtcatc ccccaggaga tcgaagaggt gaaagcactc attgcagaac accagacctt    15540

catggaggaa atgaccagaa aacagcctga tgttgataaa gtaacgaaga cctataagag    15600

gagagctgct gatccttcct cattacaatc ccatattcca gtcttggata agggacgagc    15660

aggaagaaaa cgctttccag catcaagctt gtatccctct gggtcacaga cacaaattga    15720

aaccaaaaat cctagggtaa acttactggt gagcaaatgg cagcaagtct ggctcctggc    15780

gttggaaaga aggaggaaac tcaatgatgc cttggacaga ctagaggagc tgagggaatt    15840

tgctaacttt gattttgata tctggcgcaa aaaatacatg cgatggatga atcacaagaa    15900

atctcgagtg atggacttct tcaggagaat tgataaagac caggatggga aaataacgcg    15960

gcaggaattt attgatggaa ttctttcctc aaagtttcca accagtcgct tggagatgag    16020

cgcagttgca gacatctttg acagagatgg cgatggatat attgactact atgaatttgt    16080

agcagccctt cacccaaata aagatgcata taaacctatc acagatgccg acaaaatcga    16140

agatgaggtg acaaggcagg tagctaagtg taaatgtgca aagcgatttc aagttgagca    16200

gattggtgat aataaataca ggttcttcct gggaaatcag tttggagact cccagcaact    16260

gcgactggtc cggatcctgc ggagtactgt gatggttcgt gttggaggtg gatggatggc    16320

acttgatgag ttcttagtga aaaatgatcc ttgcagggcc aaaggaagga caaacatgga    16380

actgcgtgag aagttcattt tagcagatgg tgccagccag ggtatggctg ctttccgacc    16440

ccgaggccga agatcccggc catcatcacg aggcgcttca cccaacagat ccacttctgt    16500

gtccagtcag gctgcgcagg cggcctcccc acaggtccct gccaccacca cacccaagat    16560

tctccatcct ttaacacgca attatggtaa accatggttg acaaacagca aaatgtcaac    16620

tccttgtaaa gcagcagagt gctcagactt tcccgtgcca tctgcagagg gaacgccaat    16680

acaaggaagc aagcttcgac ttccaggata tttatcaggg aaaggcttcc actctgggga    16740

ggacagtggc ttgataacaa ctgcagctgc cagagtccga acacagtttg ctgattccaa    16800

gaagactccc agccgaccag gaagtcgagc tggaagcaaa gctggcagca gggccagcag    16860

ccgccgaggc agtgatgcat cagactttga catttcagaa atccagtccg tgtgctcaga    16920

tgtggaaact gtcccccaga cacacagacc tacaccccga gcaggttctc ggccatccac    16980

agcgaagcct tcaaaaatcc ccacgcccca gaggaaatca cctgccagca aattggacaa    17040

gtcctcaaag agatagtgca attggttcta ccaaggccct tccttgagca tttattattt    17100

aagtttgaac gatgtaaaat atggtgtaga aattcttgtg aaatattgca agaggcgagt    17160

ttaaaattct gcagatggcc ttatttgtgt atttgtcttt ttattttatc tgtataattt    17220

tttttgtcag atattctggg gttaaagtca catcatatgt gaggaggaaa agtttaacat    17280

gaactaacat ttctgcactg taacgtgccg ggcacacact aaactcagtt actgtaccta    17340

caggtaagtc tacatcctct ctgacagcca cagcactaca tcaatccctg acgttaggga    17400

tacctcatga cattttcctg tttttatgga aactctgaga agctgaatga tacatgcagg    17460

ggatattttt tgagatgatt taaatgtaaa ccaaaagatg gaagacaaaa agacaaacac    17520

acccacacgc agtctttgca gtatctgaca gagaactcac aggaagttac ttcaagcact    17580

tgccagtact atgatattca agtaccttgc agcatttctc tgccattgct ttcaatgagg    17640

ccagaggcat cctggatatt agacctatta tactgtaaga atataagtat aaagtgcgtt    17700

catatacatg tgaggttttc ttttgcttga gtggacagta gcacctgtat cattgaactc    17760

attttgtatc agagcaattt tgcttgcaga aagctatgaa ataaaacacg tcccttaact    17820

gcattgctat ggaattaatt ttttttcccc agggaaaact agtgtatttt tttatgagca    17880

atatcaattt ggagtgacca aaagatactt aaaaatgggt ttattttgat ttctcatctg    17940

aaataatcat gttctggtat tatatctatc tatatttaat aaatatatac attttaattt    18000

attatgtgta ctcacatact atagaaagat attagtatgc atttaataaa acatattcac    18060

ttgaatatat ggaaaaaaaa aaaaaaaaaa                                     18090


<210>  597
<211>  5675
<212>  PRT
<213>  Homo Sapiens

<400>  597

Met Ile Ala Ala Ala Phe Leu Val Leu Leu Arg Pro Tyr Ser Ile Gln 
1               5                   10                  15      


Cys Ala Leu Phe Leu Leu Leu Leu Leu Leu Gly Thr Ile Ala Thr Ile 
            20                  25                  30          


Val Phe Phe Cys Cys Trp His Arg Lys Leu Gln Lys Gly Arg His Pro 
        35                  40                  45              


Met Lys Ser Val Phe Ser Gly Arg Ser Arg Ser Arg Asp Ala Val Leu 
    50                  55                  60                  


Arg Ser His His Phe Arg Ser Glu Gly Phe Arg Ala Ser Pro Arg His 
65                  70                  75                  80  


Leu Arg Arg Arg Val Ala Ala Ala Ala Ala Ala Arg Leu Glu Glu Val 
                85                  90                  95      


Lys Pro Val Val Glu Val His His Gln Ser Glu Gln Glu Thr Ser Val 
            100                 105                 110         


Arg Lys Arg Arg Ile Lys Lys Ser Ser Arg Val Gln Pro Glu Phe Tyr 
        115                 120                 125             


His Ser Val Gln Gly Ala Ser Ile Arg Arg Pro Ser Ser Gly Asn Ala 
    130                 135                 140                 


Ser Tyr Arg Cys Ser Met Ser Ser Ser Ala Asp Phe Ser Asp Glu Asp 
145                 150                 155                 160 


Asp Phe Ser Gln Lys Ser Gly Ser Ala Ser Pro Ala Pro Gly Asp Thr 
                165                 170                 175     


Leu Pro Trp Asn Leu Pro Lys His Glu Arg Ser Lys Arg Lys Ile Gln 
            180                 185                 190         


Gly Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Leu Arg Ile Ala 
        195                 200                 205             


Asp Glu Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn 
    210                 215                 220                 


Gln His Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp 
225                 230                 235                 240 


Leu Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly 
                245                 250                 255     


Asp Thr Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln 
            260                 265                 270         


Asn Val Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu 
        275                 280                 285             


Val Asn Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr 
    290                 295                 300                 


Leu Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile 
305                 310                 315                 320 


His Val Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu 
                325                 330                 335     


Leu Trp Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu 
            340                 345                 350         


Asn Phe Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile 
        355                 360                 365             


His Lys Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln 
    370                 375                 380                 


Ser Asn Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile 
385                 390                 395                 400 


Gly Val Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro 
                405                 410                 415     


Asp Glu Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe 
            420                 425                 430         


Pro Lys Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu 
        435                 440                 445             


Val Lys Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp 
    450                 455                 460                 


Ile Arg His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn 
465                 470                 475                 480 


Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu 
                485                 490                 495     


Thr Glu Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu 
            500                 505                 510         


Tyr Lys Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu 
        515                 520                 525             


Gln Gly Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile 
    530                 535                 540                 


Ile Ala Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg 
545                 550                 555                 560 


Leu Glu Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val 
                565                 570                 575     


Ile Cys Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp 
            580                 585                 590         


Ser Lys Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile 
        595                 600                 605             


Ala Gly Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile 
    610                 615                 620                 


Asp Val Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu 
625                 630                 635                 640 


Val Gln Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn 
                645                 650                 655     


Glu Cys Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln 
            660                 665                 670         


Thr Lys Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe 
        675                 680                 685             


Ala Gln Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu 
    690                 695                 700                 


Thr Pro Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly 
705                 710                 715                 720 


Met Thr Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly 
                725                 730                 735     


Phe Pro Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn 
            740                 745                 750         


Ser Leu Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys 
        755                 760                 765             


Ser Ser Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys 
    770                 775                 780                 


Phe Val Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu 
785                 790                 795                 800 


Asp Arg Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu 
                805                 810                 815     


Glu Asn His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser 
            820                 825                 830         


Leu Lys Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys 
        835                 840                 845             


Leu Thr Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys 
    850                 855                 860                 


Leu Leu Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His 
865                 870                 875                 880 


Asn Phe Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys 
                885                 890                 895     


Glu Glu Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile 
            900                 905                 910         


Ala Arg Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln 
        915                 920                 925             


Lys Glu Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu 
    930                 935                 940                 


Leu Glu Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala 
945                 950                 955                 960 


Met Gln Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu 
                965                 970                 975     


Gln His Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala 
            980                 985                 990         


Lys Glu Ala Thr Asp Tyr Leu Arg  Asn Leu Lys Asp Ala  Ile Gln Arg 
        995                 1000                 1005             


Lys Tyr  Ser Cys Asp Arg Ser  Ser Ser Ile His Lys  Leu Glu Asp 
    1010                 1015                 1020             


Leu Val  Gln Glu Ser Met Glu  Glu Lys Glu Glu Leu  Leu Gln Tyr 
    1025                 1030                 1035             


Lys Ser  Thr Ile Ala Asn Leu  Met Gly Lys Ala Lys  Thr Ile Ile 
    1040                 1045                 1050             


Gln Leu  Lys Pro Arg Asn Ser  Asp Cys Pro Leu Lys  Thr Ser Ile 
    1055                 1060                 1065             


Pro Ile  Lys Ala Ile Cys Asp  Tyr Arg Gln Ile Glu  Ile Thr Ile 
    1070                 1075                 1080             


Tyr Lys  Asp Asp Glu Cys Val  Leu Ala Asn Asn Ser  His Arg Ala 
    1085                 1090                 1095             


Lys Trp  Lys Val Ile Ser Pro  Thr Gly Asn Glu Ala  Met Val Pro 
    1100                 1105                 1110             


Ser Val  Cys Phe Thr Val Pro  Pro Pro Asn Lys Glu  Ala Val Asp 
    1115                 1120                 1125             


Leu Ala  Asn Arg Ile Glu Gln  Gln Tyr Gln Asn Val  Leu Thr Leu 
    1130                 1135                 1140             


Trp His  Glu Ser His Ile Asn  Met Lys Ser Val Val  Ser Trp His 
    1145                 1150                 1155             


Tyr Leu  Ile Asn Glu Ile Asp  Arg Ile Arg Ala Ser  Asn Val Ala 
    1160                 1165                 1170             


Ser Ile  Lys Thr Met Leu Pro  Gly Glu His Gln Gln  Val Leu Ser 
    1175                 1180                 1185             


Asn Leu  Gln Ser Arg Phe Glu  Asp Phe Leu Glu Asp  Ser Gln Glu 
    1190                 1195                 1200             


Ser Gln  Val Phe Ser Gly Ser  Asp Ile Thr Gln Leu  Glu Lys Glu 
    1205                 1210                 1215             


Val Asn  Val Cys Lys Gln Tyr  Tyr Gln Glu Leu Leu  Lys Ser Ala 
    1220                 1225                 1230             


Glu Arg  Glu Glu Gln Glu Glu  Ser Val Tyr Asn Leu  Tyr Ile Ser 
    1235                 1240                 1245             


Glu Val  Arg Asn Ile Arg Leu  Arg Leu Glu Asn Cys  Glu Asp Arg 
    1250                 1255                 1260             


Leu Ile  Arg Gln Ile Arg Thr  Pro Leu Glu Arg Asp  Asp Leu His 
    1265                 1270                 1275             


Glu Ser  Val Phe Arg Ile Thr  Glu Gln Glu Lys Leu  Lys Lys Glu 
    1280                 1285                 1290             


Leu Glu  Arg Leu Lys Asp Asp  Leu Gly Thr Ile Thr  Asn Lys Cys 
    1295                 1300                 1305             


Glu Glu  Phe Phe Ser Gln Ala  Ala Ala Ser Ser Ser  Val Pro Thr 
    1310                 1315                 1320             


Leu Arg  Ser Glu Leu Asn Val  Val Leu Gln Asn Met  Asn Gln Val 
    1325                 1330                 1335             


Tyr Ser  Met Ser Ser Thr Tyr  Ile Asp Lys Leu Lys  Thr Val Asn 
    1340                 1345                 1350             


Leu Val  Leu Lys Asn Thr Gln  Ala Ala Glu Ala Leu  Val Lys Leu 
    1355                 1360                 1365             


Tyr Glu  Thr Lys Leu Cys Glu  Glu Glu Ala Val Ile  Ala Asp Lys 
    1370                 1375                 1380             


Asn Asn  Ile Glu Asn Leu Ile  Ser Thr Leu Lys Gln  Trp Arg Ser 
    1385                 1390                 1395             


Glu Val  Asp Glu Lys Arg Gln  Val Phe His Ala Leu  Glu Asp Glu 
    1400                 1405                 1410             


Leu Gln  Lys Ala Lys Ala Ile  Ser Asp Glu Met Phe  Lys Thr Tyr 
    1415                 1420                 1425             


Lys Glu  Arg Asp Leu Asp Phe  Asp Trp His Lys Glu  Lys Ala Asp 
    1430                 1435                 1440             


Gln Leu  Val Glu Arg Trp Gln  Asn Val His Val Gln  Ile Asp Asn 
    1445                 1450                 1455             


Arg Leu  Arg Asp Leu Glu Gly  Ile Gly Lys Ser Leu  Lys Tyr Tyr 
    1460                 1465                 1470             


Arg Asp  Thr Tyr His Pro Leu  Asp Asp Trp Ile Gln  Gln Val Glu 
    1475                 1480                 1485             


Thr Thr  Gln Arg Lys Ile Gln  Glu Asn Gln Pro Glu  Asn Ser Lys 
    1490                 1495                 1500             


Thr Leu  Ala Thr Gln Leu Asn  Gln Gln Lys Met Leu  Val Ser Glu 
    1505                 1510                 1515             


Ile Glu  Met Lys Gln Ser Lys  Met Asp Glu Cys Gln  Lys Tyr Ala 
    1520                 1525                 1530             


Glu Gln  Tyr Ser Ala Thr Val  Lys Asp Tyr Glu Leu  Gln Thr Met 
    1535                 1540                 1545             


Thr Tyr  Arg Ala Met Val Asp  Ser Gln Gln Lys Ser  Pro Val Lys 
    1550                 1555                 1560             


Arg Arg  Arg Met Gln Ser Ser  Ala Asp Leu Ile Ile  Gln Glu Phe 
    1565                 1570                 1575             


Met Asp  Leu Arg Thr Arg Tyr  Thr Ala Leu Val Thr  Leu Met Thr 
    1580                 1585                 1590             


Gln Tyr  Ile Lys Phe Ala Gly  Asp Ser Leu Lys Arg  Leu Glu Glu 
    1595                 1600                 1605             


Glu Glu  Lys Ser Leu Glu Glu  Glu Lys Lys Glu His  Val Glu Lys 
    1610                 1615                 1620             


Ala Lys  Glu Leu Gln Lys Trp  Val Ser Asn Ile Ser  Lys Thr Leu 
    1625                 1630                 1635             


Lys Asp  Ala Glu Lys Ala Gly  Lys Pro Pro Phe Ser  Lys Gln Lys 
    1640                 1645                 1650             


Ile Ser  Ser Glu Glu Ile Ser  Thr Lys Lys Glu Gln  Leu Ser Glu 
    1655                 1660                 1665             


Ala Leu  Gln Thr Ile Gln Leu  Phe Leu Ala Lys His  Gly Asp Lys 
    1670                 1675                 1680             


Met Thr  Asp Glu Glu Arg Asn  Glu Leu Glu Lys Gln  Val Lys Thr 
    1685                 1690                 1695             


Leu Gln  Glu Ser Tyr Asn Leu  Leu Phe Ser Glu Ser  Leu Lys Gln 
    1700                 1705                 1710             


Leu Gln  Glu Ser Gln Thr Ser  Gly Asp Val Lys Val  Glu Glu Lys 
    1715                 1720                 1725             


Ile Val  Ala Glu Arg Gln Gln  Glu Tyr Lys Glu Lys  Leu Gln Gly 
    1730                 1735                 1740             


Ile Cys  Asp Leu Leu Thr Gln  Thr Glu Asn Arg Leu  Ile Gly His 
    1745                 1750                 1755             


Gln Glu  Ala Phe Met Ile Gly  Asp Gly Thr Val Glu  Leu Lys Lys 
    1760                 1765                 1770             


Tyr Gln  Ser Lys Gln Glu Glu  Leu Gln Lys Asp Met  Gln Gly Ser 
    1775                 1780                 1785             


Ala Gln  Ala Leu Ala Glu Val  Val Lys Asn Thr Glu  Asn Phe Leu 
    1790                 1795                 1800             


Lys Glu  Asn Gly Glu Lys Leu  Ser Gln Glu Asp Lys  Ala Leu Ile 
    1805                 1810                 1815             


Glu Gln  Lys Leu Asn Glu Ala  Lys Ile Lys Cys Glu  Gln Leu Asn 
    1820                 1825                 1830             


Leu Lys  Ala Glu Gln Ser Lys  Lys Glu Leu Asp Lys  Val Val Thr 
    1835                 1840                 1845             


Thr Ala  Ile Lys Glu Glu Thr  Glu Lys Val Ala Ala  Val Lys Gln 
    1850                 1855                 1860             


Leu Glu  Glu Ser Lys Thr Lys  Ile Glu Asn Leu Leu  Asp Trp Leu 
    1865                 1870                 1875             


Ser Asn  Val Asp Lys Asp Ser  Glu Arg Ala Gly Thr  Lys His Lys 
    1880                 1885                 1890             


Gln Val  Ile Glu Gln Asn Gly  Thr His Phe Gln Glu  Gly Asp Gly 
    1895                 1900                 1905             


Lys Ser  Ala Ile Gly Glu Glu  Asp Glu Val Asn Gly  Asn Leu Leu 
    1910                 1915                 1920             


Glu Thr  Asp Val Asp Gly Gln  Val Gly Thr Thr Gln  Glu Asn Leu 
    1925                 1930                 1935             


Asn Gln  Gln Tyr Gln Lys Val  Lys Ala Gln His Glu  Lys Ile Ile 
    1940                 1945                 1950             


Ser Gln  His Gln Ala Val Ile  Ile Ala Thr Gln Ser  Ala Gln Val 
    1955                 1960                 1965             


Leu Leu  Glu Lys Gln Gly Gln  Tyr Leu Ser Pro Glu  Glu Lys Glu 
    1970                 1975                 1980             


Lys Leu  Gln Lys Asn Met Lys  Glu Leu Lys Val His  Tyr Glu Thr 
    1985                 1990                 1995             


Ala Leu  Ala Glu Ser Glu Lys  Lys Met Lys Leu Thr  His Ser Leu 
    2000                 2005                 2010             


Gln Glu  Glu Leu Glu Lys Phe  Asp Ala Asp Tyr Thr  Glu Phe Glu 
    2015                 2020                 2025             


His Trp  Leu Gln Gln Ser Glu  Gln Glu Leu Glu Asn  Leu Glu Ala 
    2030                 2035                 2040             


Gly Ala  Asp Asp Ile Asn Gly  Leu Met Thr Lys Leu  Lys Arg Gln 
    2045                 2050                 2055             


Lys Ser  Phe Ser Glu Asp Val  Ile Ser His Lys Gly  Asp Leu Arg 
    2060                 2065                 2070             


Tyr Ile  Thr Ile Ser Gly Asn  Arg Val Leu Glu Ala  Ala Lys Ser 
    2075                 2080                 2085             


Cys Ser  Lys Arg Asp Gly Gly  Lys Val Asp Thr Ser  Ala Thr His 
    2090                 2095                 2100             


Arg Glu  Val Gln Arg Lys Leu  Asp His Ala Thr Asp  Arg Phe Arg 
    2105                 2110                 2115             


Ser Leu  Tyr Ser Lys Cys Asn  Val Leu Gly Asn Asn  Leu Lys Asp 
    2120                 2125                 2130             


Leu Val  Asp Lys Tyr Gln His  Tyr Glu Asp Ala Ser  Cys Gly Leu 
    2135                 2140                 2145             


Leu Ala  Gly Leu Gln Ala Cys  Glu Ala Thr Ala Ser  Lys His Leu 
    2150                 2155                 2160             


Ser Glu  Pro Ile Ala Val Asp  Pro Lys Asn Leu Gln  Arg Gln Leu 
    2165                 2170                 2175             


Glu Glu  Thr Lys Ala Leu Gln  Gly Gln Ile Ser Ser  Gln Gln Val 
    2180                 2185                 2190             


Ala Val  Glu Lys Leu Lys Lys  Thr Ala Glu Val Leu  Leu Asp Ala 
    2195                 2200                 2205             


Arg Gly  Ser Leu Leu Pro Ala  Lys Asn Asp Ile Gln  Lys Thr Leu 
    2210                 2215                 2220             


Asp Asp  Ile Val Gly Arg Tyr  Glu Asp Leu Ser Lys  Ser Val Asn 
    2225                 2230                 2235             


Glu Arg  Asn Glu Lys Leu Gln  Ile Thr Leu Thr Arg  Ser Leu Ser 
    2240                 2245                 2250             


Val Gln  Asp Gly Leu Asp Glu  Met Leu Asp Trp Met  Gly Asn Val 
    2255                 2260                 2265             


Glu Ser  Ser Leu Lys Glu Gln  Gly Gln Val Pro Leu  Asn Ser Thr 
    2270                 2275                 2280             


Ala Leu  Gln Asp Ile Ile Ser  Lys Asn Ile Met Leu  Glu Gln Asp 
    2285                 2290                 2295             


Ile Ala  Gly Arg Gln Ser Ser  Ile Asn Ala Met Asn  Glu Lys Val 
    2300                 2305                 2310             


Lys Lys  Phe Met Glu Thr Thr  Asp Pro Ser Thr Ala  Ser Ser Leu 
    2315                 2320                 2325             


Gln Ala  Lys Met Lys Asp Leu  Ser Ala Arg Phe Ser  Glu Ala Ser 
    2330                 2335                 2340             


His Lys  His Lys Glu Thr Leu  Ala Lys Met Glu Glu  Leu Lys Thr 
    2345                 2350                 2355             


Lys Val  Glu Leu Phe Glu Asn  Leu Ser Glu Lys Leu  Gln Thr Phe 
    2360                 2365                 2370             


Leu Glu  Thr Lys Thr Gln Ala  Leu Thr Glu Val Asp  Val Pro Gly 
    2375                 2380                 2385             


Lys Asp  Val Thr Glu Leu Ser  Gln Tyr Met Gln Glu  Ser Thr Ser 
    2390                 2395                 2400             


Glu Phe  Leu Glu His Lys Lys  His Leu Glu Val Leu  His Ser Leu 
    2405                 2410                 2415             


Leu Lys  Glu Ile Ser Ser His  Gly Leu Pro Ser Asp  Lys Ala Leu 
    2420                 2425                 2430             


Val Leu  Glu Lys Thr Asn Asn  Leu Ser Lys Lys Phe  Lys Glu Met 
    2435                 2440                 2445             


Glu Asp  Thr Ile Lys Glu Lys  Lys Glu Ala Val Thr  Ser Cys Gln 
    2450                 2455                 2460             


Glu Gln  Leu Asp Ala Phe Gln  Val Leu Val Lys Ser  Leu Lys Ser 
    2465                 2470                 2475             


Trp Ile  Lys Glu Thr Thr Lys  Lys Val Pro Ile Val  Gln Pro Ser 
    2480                 2485                 2490             


Phe Gly  Ala Glu Asp Leu Gly  Lys Ser Leu Glu Asp  Thr Lys Lys 
    2495                 2500                 2505             


Leu Gln  Glu Lys Trp Ser Leu  Lys Thr Pro Glu Ile  Gln Lys Val 
    2510                 2515                 2520             


Asn Asn  Ser Gly Ile Ser Leu  Cys Asn Leu Ile Ser  Ala Val Thr 
    2525                 2530                 2535             


Thr Pro  Ala Lys Ala Ile Ala  Ala Val Lys Ser Gly  Gly Ala Val 
    2540                 2545                 2550             


Leu Asn  Gly Glu Gly Thr Ala  Thr Asn Thr Glu Glu  Phe Trp Ala 
    2555                 2560                 2565             


Asn Lys  Gly Leu Thr Ser Ile  Lys Lys Asp Met Thr  Asp Ile Ser 
    2570                 2575                 2580             


His Gly  Tyr Glu Asp Leu Gly  Leu Leu Leu Lys Asp  Lys Ile Ala 
    2585                 2590                 2595             


Glu Leu  Asn Thr Lys Leu Ser  Lys Leu Gln Lys Ala  Gln Glu Glu 
    2600                 2605                 2610             


Ser Ser  Ala Met Met Gln Trp  Leu Gln Lys Met Asn  Lys Thr Ala 
    2615                 2620                 2625             


Thr Lys  Trp Gln Gln Thr Pro  Ala Pro Thr Asp Thr  Glu Ala Val 
    2630                 2635                 2640             


Lys Thr  Gln Val Glu Gln Asn  Lys Ser Phe Glu Ala  Glu Leu Lys 
    2645                 2650                 2655             


Gln Asn  Val Asn Lys Val Gln  Glu Leu Lys Asp Lys  Leu Thr Glu 
    2660                 2665                 2670             


Leu Leu  Glu Glu Asn Pro Asp  Thr Pro Glu Ala Pro  Arg Trp Lys 
    2675                 2680                 2685             


Gln Met  Leu Thr Glu Ile Asp  Ser Lys Trp Gln Glu  Leu Asn Gln 
    2690                 2695                 2700             


Leu Thr  Ile Asp Arg Gln Gln  Lys Leu Glu Glu Ser  Ser Asn Asn 
    2705                 2710                 2715             


Leu Thr  Gln Phe Gln Thr Val  Glu Ala Gln Leu Lys  Gln Trp Leu 
    2720                 2725                 2730             


Val Glu  Lys Glu Leu Met Val  Ser Val Leu Gly Pro  Leu Ser Ile 
    2735                 2740                 2745             


Asp Pro  Asn Met Leu Asn Thr  Gln Arg Gln Gln Val  Gln Ile Leu 
    2750                 2755                 2760             


Leu Gln  Glu Phe Ala Thr Arg  Lys Pro Gln Tyr Glu  Gln Leu Thr 
    2765                 2770                 2775             


Ala Ala  Gly Gln Gly Ile Leu  Ser Arg Pro Gly Glu  Asp Pro Ser 
    2780                 2785                 2790             


Leu Arg  Gly Ile Val Lys Glu  Gln Leu Ala Ala Val  Thr Gln Lys 
    2795                 2800                 2805             


Trp Asp  Ser Leu Thr Gly Gln  Leu Ser Asp Arg Cys  Asp Trp Ile 
    2810                 2815                 2820             


Asp Gln  Ala Ile Val Lys Ser  Thr Gln Tyr Gln Ser  Leu Leu Arg 
    2825                 2830                 2835             


Ser Leu  Ser Asp Lys Leu Ser  Asp Leu Asp Asn Lys  Leu Ser Ser 
    2840                 2845                 2850             


Ser Leu  Ala Val Ser Thr His  Pro Asp Ala Met Asn  Gln Gln Leu 
    2855                 2860                 2865             


Glu Thr  Ala Gln Lys Met Lys  Gln Glu Ile Gln Gln  Glu Lys Lys 
    2870                 2875                 2880             


Gln Ile  Lys Val Ala Gln Ala  Leu Cys Glu Asp Leu  Ser Ala Leu 
    2885                 2890                 2895             


Val Lys  Glu Glu Tyr Leu Lys  Ala Glu Leu Ser Arg  Gln Leu Glu 
    2900                 2905                 2910             


Gly Ile  Leu Lys Ser Phe Lys  Asp Val Glu Gln Lys  Ala Glu Asn 
    2915                 2920                 2925             


His Val  Gln His Leu Gln Ser  Ala Cys Ala Ser Ser  His Gln Phe 
    2930                 2935                 2940             


Gln Gln  Met Ser Arg Asp Phe  Gln Ala Trp Leu Asp  Thr Lys Lys 
    2945                 2950                 2955             


Glu Glu  Gln Asn Lys Ser His  Pro Ile Ser Ala Lys  Leu Asp Val 
    2960                 2965                 2970             


Leu Glu  Ser Leu Ile Lys Asp  His Lys Asp Phe Ser  Lys Thr Leu 
    2975                 2980                 2985             


Thr Ala  Gln Ser His Met Tyr  Glu Lys Thr Ile Ala  Glu Gly Glu 
    2990                 2995                 3000             


Asn Leu  Leu Leu Lys Thr Gln  Gly Ser Glu Lys Ala  Ala Leu Gln 
    3005                 3010                 3015             


Leu Gln  Leu Asn Thr Ile Lys  Thr Asn Trp Asp Thr  Phe Asn Lys 
    3020                 3025                 3030             


Gln Val  Lys Glu Arg Glu Asn  Lys Leu Lys Glu Ser  Leu Glu Lys 
    3035                 3040                 3045             


Ala Leu  Lys Tyr Lys Glu Gln  Val Glu Thr Leu Trp  Pro Trp Ile 
    3050                 3055                 3060             


Asp Lys  Cys Gln Asn Asn Leu  Glu Glu Ile Lys Phe  Cys Leu Asp 
    3065                 3070                 3075             


Pro Ala  Glu Gly Glu Asn Ser  Ile Ala Lys Leu Lys  Ser Leu Gln 
    3080                 3085                 3090             


Lys Glu  Met Asp Gln His Phe  Gly Met Val Glu Leu  Leu Asn Asn 
    3095                 3100                 3105             


Thr Ala  Asn Ser Leu Leu Ser  Val Cys Glu Ile Asp  Lys Glu Val 
    3110                 3115                 3120             


Val Thr  Asp Glu Asn Lys Ser  Leu Ile Gln Lys Val  Asp Met Val 
    3125                 3130                 3135             


Thr Glu  Gln Leu His Ser Lys  Lys Phe Cys Leu Glu  Asn Met Thr 
    3140                 3145                 3150             


Gln Lys  Phe Lys Glu Phe Gln  Glu Val Ser Lys Glu  Ser Lys Arg 
    3155                 3160                 3165             


Gln Leu  Gln Cys Ala Lys Glu  Gln Leu Asp Ile His  Asp Ser Leu 
    3170                 3175                 3180             


Gly Ser  Gln Ala Tyr Ser Asn  Lys Tyr Leu Thr Met  Leu Gln Thr 
    3185                 3190                 3195             


Gln Gln  Lys Ser Leu Gln Ala  Leu Lys His Gln Val  Asp Leu Ala 
    3200                 3205                 3210             


Lys Arg  Leu Ala Gln Asp Leu  Val Val Glu Ala Ser  Asp Ser Lys 
    3215                 3220                 3225             


Gly Thr  Ser Asp Val Leu Leu  Gln Val Glu Thr Ile  Ala Gln Glu 
    3230                 3235                 3240             


His Ser  Thr Leu Ser Gln Gln  Val Asp Glu Lys Cys  Ser Phe Leu 
    3245                 3250                 3255             


Glu Thr  Lys Leu Gln Gly Ile  Gly His Phe Gln Asn  Thr Ile Arg 
    3260                 3265                 3270             


Glu Met  Phe Ser Gln Phe Ala  Glu Phe Asp Asp Glu  Leu Asp Ser 
    3275                 3280                 3285             


Met Ala  Pro Val Gly Arg Asp  Ala Glu Thr Leu Gln  Lys Gln Lys 
    3290                 3295                 3300             


Glu Thr  Ile Lys Ala Phe Leu  Lys Lys Leu Glu Ala  Leu Met Ala 
    3305                 3310                 3315             


Ser Asn  Asp Asn Ala Asn Lys  Thr Cys Lys Met Met  Leu Ala Thr 
    3320                 3325                 3330             


Glu Glu  Thr Ser Pro Asp Leu  Val Gly Ile Lys Arg  Asp Leu Glu 
    3335                 3340                 3345             


Ala Leu  Ser Lys Gln Cys Asn  Lys Leu Leu Asp Arg  Ala Gln Ala 
    3350                 3355                 3360             


Arg Glu  Glu Gln Val Glu Gly  Thr Ile Lys Arg Leu  Glu Glu Phe 
    3365                 3370                 3375             


Tyr Ser  Lys Leu Lys Glu Phe  Ser Ile Leu Leu Gln  Lys Ala Glu 
    3380                 3385                 3390             


Glu His  Glu Glu Ser Gln Gly  Pro Val Gly Met Glu  Thr Glu Thr 
    3395                 3400                 3405             


Ile Asn  Gln Gln Leu Asn Met  Phe Lys Val Phe Gln  Lys Glu Glu 
    3410                 3415                 3420             


Ile Glu  Pro Leu Gln Gly Lys  Gln Gln Asp Val Asn  Trp Leu Gly 
    3425                 3430                 3435             


Gln Gly  Leu Ile Gln Ser Ala  Ala Lys Ser Thr Ser  Thr Gln Gly 
    3440                 3445                 3450             


Leu Glu  His Asp Leu Asp Asp  Val Asn Ala Arg Trp  Lys Thr Leu 
    3455                 3460                 3465             


Asn Lys  Lys Val Ala Gln Arg  Ala Ala Gln Leu Gln  Glu Ala Leu 
    3470                 3475                 3480             


Leu His  Cys Gly Arg Phe Gln  Asp Ala Leu Glu Ser  Leu Leu Ser 
    3485                 3490                 3495             


Trp Met  Val Asp Thr Glu Glu  Leu Val Ala Asn Gln  Lys Pro Pro 
    3500                 3505                 3510             


Ser Ala  Glu Phe Lys Val Val  Lys Ala Gln Ile Gln  Glu Gln Lys 
    3515                 3520                 3525             


Leu Leu  Gln Arg Leu Leu Asp  Asp Arg Lys Ser Thr  Val Glu Val 
    3530                 3535                 3540             


Ile Lys  Arg Glu Gly Glu Lys  Ile Ala Thr Thr Ala  Glu Pro Ala 
    3545                 3550                 3555             


Asp Lys  Val Lys Ile Leu Lys  Gln Leu Ser Leu Leu  Asp Ser Arg 
    3560                 3565                 3570             


Trp Glu  Ala Leu Leu Asn Lys  Ala Glu Thr Arg Asn  Arg Gln Leu 
    3575                 3580                 3585             


Glu Gly  Ile Ser Val Val Ala  Gln Gln Phe His Glu  Thr Leu Glu 
    3590                 3595                 3600             


Pro Leu  Asn Glu Trp Leu Thr  Thr Ile Glu Lys Arg  Leu Val Asn 
    3605                 3610                 3615             


Cys Glu  Pro Ile Gly Thr Gln  Ala Ser Lys Leu Glu  Glu Gln Ile 
    3620                 3625                 3630             


Ala Gln  His Lys Ala Leu Glu  Asp Asp Ile Ile Asn  His Asn Lys 
    3635                 3640                 3645             


His Leu  His Gln Ala Val Ser  Ile Gly Gln Ser Leu  Lys Val Leu 
    3650                 3655                 3660             


Ser Ser  Arg Glu Asp Lys Asp  Met Val Gln Ser Lys  Leu Asp Phe 
    3665                 3670                 3675             


Ser Gln  Val Trp Tyr Ile Glu  Ile Gln Glu Lys Ser  His Ser Arg 
    3680                 3685                 3690             


Ser Glu  Leu Leu Gln Gln Ala  Leu Cys Asn Ala Lys  Ile Phe Gly 
    3695                 3700                 3705             


Glu Asp  Glu Val Glu Leu Met  Asn Trp Leu Asn Glu  Val His Asp 
    3710                 3715                 3720             


Lys Leu  Ser Lys Leu Ser Val  Gln Asp Tyr Ser Thr  Glu Gly Leu 
    3725                 3730                 3735             


Trp Lys  Gln Gln Ser Glu Leu  Arg Val Leu Gln Glu  Asp Ile Leu 
    3740                 3745                 3750             


Leu Arg  Lys Gln Asn Val Asp  Gln Ala Leu Leu Asn  Gly Leu Glu 
    3755                 3760                 3765             


Leu Leu  Lys Gln Thr Thr Gly  Asp Glu Val Leu Ile  Ile Gln Asp 
    3770                 3775                 3780             


Lys Leu  Glu Ala Ile Lys Ala  Arg Tyr Lys Asp Ile  Thr Lys Leu 
    3785                 3790                 3795             


Ser Thr  Asp Val Ala Lys Thr  Leu Glu Gln Ala Leu  Gln Leu Ala 
    3800                 3805                 3810             


Arg Arg  Leu His Ser Thr His  Glu Glu Leu Cys Thr  Trp Leu Asp 
    3815                 3820                 3825             


Lys Val  Glu Val Glu Leu Leu  Ser Tyr Glu Thr Gln  Val Leu Lys 
    3830                 3835                 3840             


Gly Glu  Glu Ala Ser Gln Ala  Gln Met Arg Pro Lys  Glu Leu Lys 
    3845                 3850                 3855             


Lys Glu  Ala Lys Asn Asn Lys  Ala Leu Leu Asp Ser  Leu Asn Glu 
    3860                 3865                 3870             


Val Ser  Ser Ala Leu Leu Glu  Leu Val Pro Trp Arg  Ala Arg Glu 
    3875                 3880                 3885             


Gly Leu  Glu Lys Met Val Ala  Glu Asp Asn Glu Arg  Tyr Arg Leu 
    3890                 3895                 3900             


Val Ser  Asp Thr Ile Thr Gln  Lys Val Glu Glu Ile  Asp Ala Ala 
    3905                 3910                 3915             


Ile Leu  Arg Ser Gln Gln Phe  Asp Gln Ala Ala Asp  Ala Glu Leu 
    3920                 3925                 3930             


Ser Trp  Ile Thr Glu Thr Glu  Lys Lys Leu Met Ser  Leu Gly Asp 
    3935                 3940                 3945             


Ile Arg  Leu Glu Gln Asp Gln  Thr Ser Ala Gln Leu  Gln Val Gln 
    3950                 3955                 3960             


Lys Thr  Phe Thr Met Glu Ile  Leu Arg His Lys Asp  Ile Ile Asp 
    3965                 3970                 3975             


Asp Leu  Val Lys Ser Gly His  Lys Ile Met Thr Ala  Cys Ser Glu 
    3980                 3985                 3990             


Glu Glu  Lys Gln Ser Met Lys  Lys Lys Leu Asp Lys  Val Leu Lys 
    3995                 4000                 4005             


Asn Tyr  Asp Thr Ile Cys Gln  Ile Asn Ser Glu Arg  Tyr Leu Gln 
    4010                 4015                 4020             


Leu Glu  Arg Ala Gln Ser Leu  Val Asn Gln Phe Trp  Glu Thr Tyr 
    4025                 4030                 4035             


Glu Glu  Leu Trp Pro Trp Leu  Thr Glu Thr Gln Ser  Ile Ile Ser 
    4040                 4045                 4050             


Gln Leu  Pro Ala Pro Ala Leu  Glu Tyr Glu Thr Leu  Arg Gln Gln 
    4055                 4060                 4065             


Gln Glu  Glu His Arg Gln Leu  Arg Glu Leu Ile Ala  Glu His Lys 
    4070                 4075                 4080             


Pro His  Ile Asp Lys Met Asn  Lys Thr Gly Pro Gln  Leu Leu Glu 
    4085                 4090                 4095             


Leu Ser  Pro Gly Glu Gly Phe  Ser Ile Gln Glu Lys  Tyr Val Ala 
    4100                 4105                 4110             


Ala Asp  Thr Leu Tyr Ser Gln  Ile Lys Glu Asp Val  Lys Lys Arg 
    4115                 4120                 4125             


Ala Val  Ala Leu Asp Glu Ala  Ile Ser Gln Ser Thr  Gln Phe His 
    4130                 4135                 4140             


Asp Lys  Ile Asp Gln Ile Leu  Glu Ser Leu Glu Arg  Ile Val Glu 
    4145                 4150                 4155             


Arg Leu  Arg Gln Pro Pro Ser  Ile Ser Ala Glu Val  Glu Lys Ile 
    4160                 4165                 4170             


Lys Glu  Gln Ile Ser Glu Asn  Lys Asn Val Ser Val  Asp Met Glu 
    4175                 4180                 4185             


Lys Leu  Gln Pro Leu Tyr Glu  Thr Leu Lys Gln Arg  Gly Glu Glu 
    4190                 4195                 4200             


Met Ile  Ala Arg Ser Gly Gly  Thr Asp Lys Asp Ile  Ser Ala Lys 
    4205                 4210                 4215             


Ala Val  Gln Asp Lys Leu Asp  Gln Met Val Phe Ile  Trp Glu Asn 
    4220                 4225                 4230             


Ile His  Thr Leu Val Glu Glu  Arg Glu Ala Lys Leu  Leu Asp Val 
    4235                 4240                 4245             


Met Glu  Leu Ala Glu Lys Phe  Trp Cys Asp His Met  Ser Leu Ile 
    4250                 4255                 4260             


Val Thr  Ile Lys Asp Thr Gln  Asp Phe Ile Arg Asp  Leu Glu Asp 
    4265                 4270                 4275             


Pro Gly  Ile Asp Pro Ser Val  Val Lys Gln Gln Gln  Glu Ala Ala 
    4280                 4285                 4290             


Glu Thr  Ile Arg Glu Glu Ile  Asp Gly Leu Gln Glu  Glu Leu Asp 
    4295                 4300                 4305             


Ile Val  Ile Asn Leu Gly Ser  Glu Leu Ile Ala Ala  Cys Gly Glu 
    4310                 4315                 4320             


Pro Asp  Lys Pro Ile Val Lys  Lys Ser Ile Asp Glu  Leu Asn Ser 
    4325                 4330                 4335             


Ala Trp  Asp Ser Leu Asn Lys  Ala Trp Lys Asp Arg  Ile Asp Lys 
    4340                 4345                 4350             


Leu Glu  Glu Ala Met Gln Ala  Ala Val Gln Tyr Gln  Asp Gly Leu 
    4355                 4360                 4365             


Gln Ala  Val Phe Asp Trp Val  Asp Ile Ala Gly Gly  Lys Leu Ala 
    4370                 4375                 4380             


Ser Met  Ser Pro Ile Gly Thr  Asp Leu Glu Thr Val  Lys Gln Gln 
    4385                 4390                 4395             


Ile Glu  Glu Leu Lys Gln Phe  Lys Ser Glu Ala Tyr  Gln Gln Gln 
    4400                 4405                 4410             


Ile Glu  Met Glu Arg Leu Asn  His Gln Ala Glu Leu  Leu Leu Lys 
    4415                 4420                 4425             


Lys Val  Thr Glu Glu Ser Asp  Lys His Thr Val Gln  Asp Pro Leu 
    4430                 4435                 4440             


Met Glu  Leu Lys Leu Ile Trp  Asp Ser Leu Glu Glu  Arg Ile Ile 
    4445                 4450                 4455             


Asn Arg  Gln His Lys Leu Glu  Gly Ala Leu Leu Ala  Leu Gly Gln 
    4460                 4465                 4470             


Phe Gln  His Ala Leu Asp Glu  Leu Leu Ala Trp Leu  Thr His Thr 
    4475                 4480                 4485             


Glu Gly  Leu Leu Ser Glu Gln  Lys Pro Val Gly Gly  Asp Pro Lys 
    4490                 4495                 4500             


Ala Ile  Glu Ile Glu Leu Ala  Lys His His Val Leu  Gln Asn Asp 
    4505                 4510                 4515             


Val Leu  Ala His Gln Ser Thr  Val Glu Ala Val Asn  Lys Ala Gly 
    4520                 4525                 4530             


Asn Asp  Leu Ile Glu Ser Ser  Ala Gly Glu Glu Ala  Ser Asn Leu 
    4535                 4540                 4545             


Gln Asn  Lys Leu Glu Val Leu  Asn Gln Arg Trp Gln  Asn Val Leu 
    4550                 4555                 4560             


Glu Lys  Thr Glu Gln Arg Lys  Gln Gln Leu Asp Gly  Ala Leu Arg 
    4565                 4570                 4575             


Gln Ala  Lys Gly Phe His Gly  Glu Ile Glu Asp Leu  Gln Gln Trp 
    4580                 4585                 4590             


Leu Thr  Asp Thr Glu Arg His  Leu Leu Ala Ser Lys  Pro Leu Gly 
    4595                 4600                 4605             


Gly Leu  Pro Glu Thr Ala Lys  Glu Gln Leu Asn Val  His Met Glu 
    4610                 4615                 4620             


Val Cys  Ala Ala Phe Glu Ala  Lys Glu Glu Thr Tyr  Lys Ser Leu 
    4625                 4630                 4635             


Met Gln  Lys Gly Gln Gln Met  Leu Ala Arg Cys Pro  Lys Ser Ala 
    4640                 4645                 4650             


Glu Thr  Asn Ile Asp Gln Asp  Ile Asn Asn Leu Lys  Glu Lys Trp 
    4655                 4660                 4665             


Glu Ser  Val Glu Thr Lys Leu  Asn Glu Arg Lys Thr  Lys Leu Glu 
    4670                 4675                 4680             


Glu Ala  Leu Asn Leu Ala Met  Glu Phe His Asn Ser  Leu Gln Asp 
    4685                 4690                 4695             


Phe Ile  Asn Trp Leu Thr Gln  Ala Glu Gln Thr Leu  Asn Val Ala 
    4700                 4705                 4710             


Ser Arg  Pro Ser Leu Ile Leu  Asp Thr Val Leu Phe  Gln Ile Asp 
    4715                 4720                 4725             


Glu His  Lys Val Phe Ala Asn  Glu Val Asn Ser His  Arg Glu Gln 
    4730                 4735                 4740             


Ile Ile  Glu Leu Asp Lys Thr  Gly Thr His Leu Lys  Tyr Phe Ser 
    4745                 4750                 4755             


Gln Lys  Gln Asp Val Val Leu  Ile Lys Asn Leu Leu  Ile Ser Val 
    4760                 4765                 4770             


Gln Ser  Arg Trp Glu Lys Val  Val Gln Arg Leu Val  Glu Arg Gly 
    4775                 4780                 4785             


Arg Ser  Leu Asp Asp Ala Arg  Lys Arg Ala Lys Gln  Phe His Glu 
    4790                 4795                 4800             


Ala Trp  Ser Lys Leu Met Glu  Trp Leu Glu Glu Ser  Glu Lys Ser 
    4805                 4810                 4815             


Leu Asp  Ser Glu Leu Glu Ile  Ala Asn Asp Pro Asp  Lys Ile Lys 
    4820                 4825                 4830             


Thr Gln  Leu Ala Gln His Lys  Glu Phe Gln Lys Ser  Leu Gly Ala 
    4835                 4840                 4845             


Lys His  Ser Val Tyr Asp Thr  Thr Asn Arg Thr Gly  Arg Ser Leu 
    4850                 4855                 4860             


Lys Glu  Lys Thr Ser Leu Ala  Asp Asp Asn Leu Lys  Leu Asp Asp 
    4865                 4870                 4875             


Met Leu  Ser Glu Leu Arg Asp  Lys Trp Asp Thr Ile  Cys Gly Lys 
    4880                 4885                 4890             


Ser Val  Glu Arg Gln Asn Lys  Leu Glu Glu Ala Leu  Leu Phe Ser 
    4895                 4900                 4905             


Gly Gln  Phe Thr Asp Ala Leu  Gln Ala Leu Ile Asp  Trp Leu Tyr 
    4910                 4915                 4920             


Arg Val  Glu Pro Gln Leu Ala  Glu Asp Gln Pro Val  His Gly Asp 
    4925                 4930                 4935             


Ile Asp  Leu Val Met Asn Leu  Ile Asp Asn His Lys  Ala Phe Gln 
    4940                 4945                 4950             


Lys Glu  Leu Gly Lys Arg Thr  Ser Ser Val Gln Ala  Leu Lys Arg 
    4955                 4960                 4965             


Ser Ala  Arg Glu Leu Ile Glu  Gly Ser Arg Asp Asp  Ser Ser Trp 
    4970                 4975                 4980             


Val Lys  Val Gln Met Gln Glu  Leu Ser Thr Arg Trp  Glu Thr Val 
    4985                 4990                 4995             


Cys Ala  Leu Ser Ile Ser Lys  Gln Thr Arg Leu Glu  Ala Ala Leu 
    5000                 5005                 5010             


Arg Gln  Ala Glu Glu Phe His  Ser Val Val His Ala  Leu Leu Glu 
    5015                 5020                 5025             


Trp Leu  Ala Glu Ala Glu Gln  Thr Leu Arg Phe His  Gly Val Leu 
    5030                 5035                 5040             


Pro Asp  Asp Glu Asp Ala Leu  Arg Thr Leu Ile Asp  Gln His Lys 
    5045                 5050                 5055             


Glu Phe  Met Lys Lys Leu Glu  Glu Lys Arg Ala Glu  Leu Asn Lys 
    5060                 5065                 5070             


Ala Thr  Thr Met Gly Asp Thr  Val Leu Ala Ile Cys  His Pro Asp 
    5075                 5080                 5085             


Ser Ile  Thr Thr Ile Lys His  Trp Ile Thr Ile Ile  Arg Ala Arg 
    5090                 5095                 5100             


Phe Glu  Glu Val Leu Ala Trp  Ala Lys Gln His Gln  Gln Arg Leu 
    5105                 5110                 5115             


Ala Ser  Ala Leu Ala Gly Leu  Ile Ala Lys Gln Glu  Leu Leu Glu 
    5120                 5125                 5130             


Ala Leu  Leu Ala Trp Leu Gln  Trp Ala Glu Thr Thr  Leu Thr Asp 
    5135                 5140                 5145             


Lys Asp  Lys Glu Val Ile Pro  Gln Glu Ile Glu Glu  Val Lys Ala 
    5150                 5155                 5160             


Leu Ile  Ala Glu His Gln Thr  Phe Met Glu Glu Met  Thr Arg Lys 
    5165                 5170                 5175             


Gln Pro  Asp Val Asp Lys Val  Thr Lys Thr Tyr Lys  Arg Arg Ala 
    5180                 5185                 5190             


Ala Asp  Pro Ser Ser Leu Gln  Ser His Ile Pro Val  Leu Asp Lys 
    5195                 5200                 5205             


Gly Arg  Ala Gly Arg Lys Arg  Phe Pro Ala Ser Ser  Leu Tyr Pro 
    5210                 5215                 5220             


Ser Gly  Ser Gln Thr Gln Ile  Glu Thr Lys Asn Pro  Arg Val Asn 
    5225                 5230                 5235             


Leu Leu  Val Ser Lys Trp Gln  Gln Val Trp Leu Leu  Ala Leu Glu 
    5240                 5245                 5250             


Arg Arg  Arg Lys Leu Asn Asp  Ala Leu Asp Arg Leu  Glu Glu Leu 
    5255                 5260                 5265             


Arg Glu  Phe Ala Asn Phe Asp  Phe Asp Ile Trp Arg  Lys Lys Tyr 
    5270                 5275                 5280             


Met Arg  Trp Met Asn His Lys  Lys Ser Arg Val Met  Asp Phe Phe 
    5285                 5290                 5295             


Arg Arg  Ile Asp Lys Asp Gln  Asp Gly Lys Ile Thr  Arg Gln Glu 
    5300                 5305                 5310             


Phe Ile  Asp Gly Ile Leu Ser  Ser Lys Phe Pro Thr  Ser Arg Leu 
    5315                 5320                 5325             


Glu Met  Ser Ala Val Ala Asp  Ile Phe Asp Arg Asp  Gly Asp Gly 
    5330                 5335                 5340             


Tyr Ile  Asp Tyr Tyr Glu Phe  Val Ala Ala Leu His  Pro Asn Lys 
    5345                 5350                 5355             


Asp Ala  Tyr Lys Pro Ile Thr  Asp Ala Asp Lys Ile  Glu Asp Glu 
    5360                 5365                 5370             


Val Thr  Arg Gln Val Ala Lys  Cys Lys Cys Ala Lys  Arg Phe Gln 
    5375                 5380                 5385             


Val Glu  Gln Ile Gly Asp Asn  Lys Tyr Arg Phe Phe  Leu Gly Asn 
    5390                 5395                 5400             


Gln Phe  Gly Asp Ser Gln Gln  Leu Arg Leu Val Arg  Ile Leu Arg 
    5405                 5410                 5415             


Ser Thr  Val Met Val Arg Val  Gly Gly Gly Trp Met  Ala Leu Asp 
    5420                 5425                 5430             


Glu Phe  Leu Val Lys Asn Asp  Pro Cys Arg Ala Lys  Gly Arg Thr 
    5435                 5440                 5445             


Asn Met  Glu Leu Arg Glu Lys  Phe Ile Leu Ala Asp  Gly Ala Ser 
    5450                 5455                 5460             


Gln Gly  Met Ala Ala Phe Arg  Pro Arg Gly Arg Arg  Ser Arg Pro 
    5465                 5470                 5475             


Ser Ser  Arg Gly Ala Ser Pro  Asn Arg Ser Thr Ser  Val Ser Ser 
    5480                 5485                 5490             


Gln Ala  Ala Gln Ala Ala Ser  Pro Gln Val Pro Ala  Thr Thr Thr 
    5495                 5500                 5505             


Pro Lys  Ile Leu His Pro Leu  Thr Arg Asn Tyr Gly  Lys Pro Trp 
    5510                 5515                 5520             


Leu Thr  Asn Ser Lys Met Ser  Thr Pro Cys Lys Ala  Ala Glu Cys 
    5525                 5530                 5535             


Ser Asp  Phe Pro Val Pro Ser  Ala Glu Gly Thr Pro  Ile Gln Gly 
    5540                 5545                 5550             


Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser Gly Lys  Gly Phe His 
    5555                 5560                 5565             


Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr Ala Ala  Ala Arg Val 
    5570                 5575                 5580             


Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr Pro Ser  Arg Pro Gly 
    5585                 5590                 5595             


Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg Ala Ser  Ser Arg Arg 
    5600                 5605                 5610             


Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser Glu Ile  Gln Ser Val 
    5615                 5620                 5625             


Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr His Arg  Pro Thr Pro 
    5630                 5635                 5640             


Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys Pro Ser  Lys Ile Pro 
    5645                 5650                 5655             


Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys Leu Asp  Lys Ser Ser 
    5660                 5665                 5670             


Lys Arg  
    5675 


<210>  598
<211>  3795
<212>  DNA
<213>  Homo Sapiens

<400>  598
gttttctacc caagaatgct acttcaggag atcagtcaaa aggttagggt gatggtgacg       60

gtggaaatat agaaaaagga atttattcaa gaggtattca aaaagaagtg aaatagagat      120

gagttggaga tagattggat aaaaagagtg agggagaggg aggtgtcagg ctgcagccca      180

ggttctgagt tgccaaagag gagtcttttc ctccaggaaa ttgagacacg ccggttgtga      240

aacctactga agtgagcggc ggcgccagga ttcctgggac cccgacctct ttgcagctcg      300

cacagctaag ggcgagggcg cccttcggca gaagcagcaa accgccggca agcccagcga      360

ggagggctgc cggggtctgg gcttgggaat tggctggcac ccagcggaaa gggacgtgag      420

ctgagcggcg ggggagaaga gtgcgcaggt cagagggcgg cgcgcagcgg cgctccgcga      480

ggtccccacg ccgggcgata tggggtgcct gctgtttctg ctgctctggg cgctcctcca      540

ggcttgggga agcgctgaag tcccgcaaag gcttttcccc ctccgctgcc tccagatctc      600

gtccttcgcc aatagcagct ggacgcgcac cgacggcttg gcgtggctgg gggagctgca      660

gacgcacagc tggagcaacg actcggacac cgtccgctct ctgaagcctt ggtcccaggg      720

cacgttcagc gaccagcagt gggagacgct gcagcatata tttcgggttt atcgaagcag      780

cttcaccagg gacgtgaagg aattcgccaa aatgctacgc ttatcctatc ccttggagct      840

ccaggtgtcc gctggctgtg aggtgcaccc tgggaacgcc tcaaataact tcttccatgt      900

agcatttcaa ggaaaagata tcctgagttt ccaaggaact tcttgggagc caacccaaga      960

ggccccactt tgggtaaact tggccattca agtgctcaac caggacaagt ggacgaggga     1020

aacagtgcag tggctcctta atggcacctg cccccaattt gtcagtggcc tccttgagtc     1080

agggaagtcg gaactgaaga agcaagtgaa gcccaaggcc tggctgtccc gtggccccag     1140

tcctggccct ggccgtctgc tgctggtgtg ccatgtctca ggattctacc caaagcctgt     1200

atgggtgaag tggatgcggg gtgagcagga gcagcagggc actcagccag gggacatcct     1260

gcccaatgct gacgagacat ggtatctccg agcaaccctg gatgtggtgg ctggggaggc     1320

agctggcctg tcctgtcggg tgaagcacag cagtctagag ggccaggaca tcgtcctcta     1380

ctggggtggg agctacacct ccatgggctt gattgccttg gcagtcctgg cgtgcttgct     1440

gttcctcctc attgtgggct ttacctcccg gtttaagagg caaacttcct atcagggcgt     1500

cctgtgactc gccttgccac atctgtgtct ctggaaccca ggacctctgg acctcaggtt     1560

cctaagactt cagtcctggt ctgctcagga attgaagatg taaggaattg aagataggag     1620

agataccttg aaaaagtaga gaacagtcat gaggcagctt tcatcacacc cttttaacat     1680

ttatctaaaa gaatttaaat tctttttcaa aaattacact acaagtttat aagcccaaat     1740

ggctctgtga aatcagaagt gcaaaggtgt gcaaacttgt atctgaagac ctaccaggga     1800

caagcaggta agagctgatg tgagtgtgtg tgatgggatc tgtaaggaac tggaacacac     1860

atgtcctatc caaaggaatc agctgcagct gcttgttgtc aagtataaag tcaggacctg     1920

gcttggcttt aaccgttttt caagaaaact ggaaatctgg attttcagcg aacatgcctg     1980

attttaaaag gttgactcaa gtttttacaa aatactatgt gggacacctc aaatacatac     2040

ctactgactg atgacaaacc caggagtttg tgtgtctttt ataaaaagtt tgccctggat     2100

gtcatattgg cagttggagg acacagtttc tattgtaaat ttggatttac gactgaagaa     2160

ggacattttc tctttaaaag aaagttaggt tataagaaac agaggcgtct cacattttta     2220

cttggtgtaa ttaataaacg aagataaatc atagtgtatg tgtattatgt tgaaaaaaac     2280

tactctgagt aaggatattt ctctcaaatg gtcatcactt tttttccttg gaggaagatt     2340

gtcatgaagg catcccttcc ttcccaaaac gacaacggca acaacaacag tctcctttac     2400

ttacagctat taaaagagac aatgtaggga aagggccaac accacttggg caagcatgag     2460

ctgcagcgat gatggtgatg gtagcccagc catgctgtgt tcttatctta gagaggacag     2520

agcaggaaac ttacaggggt agcagacctt tctgatgcca aagaaataag gaggccaaaa     2580

tcatgtttgc ctagctggga ggtaaatctc ttggcagtca gggtccctga acacccagaa     2640

aaaataagtg agacttaacg gttggagagt gtttgcttga gaaaagtaac atttcacact     2700

ctctatacta gacttgcaca tatgaattta ggatgtgcgt gaagattctg ctagcttcaa     2760

catatcccaa agcacttgga tatgcctata atccaagtgc tttgggaggc tgagatagga     2820

ggattgttta aggccaggca tttgaaatca gcctgggcaa catagtgaga ccctgtctct     2880

acaaaaaatt aaaaaactag ccacccatgg tggtgagcgc ctgtagtcct agctactctg     2940

gaggctgagg tgggaggatc ccttgagccc atgaattcca ggttagtgtg agctgtgatt     3000

gtgtcactac agtgtaagga tgacagaggg agaccctgtc ttaaaaaaaa attatgctag     3060

cttttaaatc aatggttccc aaattgtagt aacctgacca acagcctcag caggacctgg     3120

gaacttgtta taaatgcaaa ttgttttggg cctcatccta tacccgctga atgagaaact     3180

ctgagtctgg aagcaggctc aatagtcaag ccccctggtg attctgatgc ttagctaaag     3240

ttagagaacc actgttctta gacattgtgc aatgttatac aacaacttcc tcaaagtgct     3300

aagtgaaaag gacattggcc tggcgttagt cagggaaggc gtcctggagg gaggggaatt     3360

tgaagcagag ctttgaaaaa caaaggcagt gaggtgaacc agcaagtgca ctggctgagg     3420

ggactggagt tctagcctct gaaccagttt cctcctgtgc caaaggagga taataattat     3480

ctattattga ttatctccta gacttgtgga gttcaagtgt gtaatgcctt aaaagatgtg     3540

gaggctgttg ctgtgtttgg taccacattg cccaccctca cgtggcgctc ttcagcttag     3600

gttcctctag cagtgtcaag tttgtgaacc aaccccactg gccttctgca ttctgagggc     3660

acgtgtgtta aagtctctac tgatgtcctt ttggaaatgc ctctgcatga atttatggta     3720

gctctgactc atctttaaac aattttaatt tatttagaaa ataaaggctt atctctccag     3780

gaaaaaaaaa aaaaa                                                      3795


<210>  599
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  599

Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210>  600
<211>  6831
<212>  DNA
<213>  Homo Sapiens

<400>  600
ccaggcccca ttgttcccgg tttccagcca tggctgccat tacctgacca gcgccacagc       60

cggtctctct gcaggcgccg ggagaagtga ccagagcaat ttctgctttt cacagggcgg      120

gtttctcaac ggtgacttgt gggcagtgcc ttctgctgag cgagtcatgg cccgaaggca      180

gaactaactg tgcctgcagt cttcactctc aggatgcagc cgaggtgggc ccaaggggcc      240

acgatgtggc ttggagtcct gctgaccctt ctgctctgtt caagccttga gggtcaagaa      300

aactctttca caatcaacag tgttgacatg aagagcctgc cggactggac ggtgcaaaat      360

gggaagaacc tgaccctgca gtgcttcgcg gatgtcagca ccacctctca cgtcaagcct      420

cagcaccaga tgctgttcta taaggatgac gtgctgtttt acaacatctc ctccatgaag      480

agcacagaga gttattttat tcctgaagtc cggatctatg actcagggac atataaatgt      540

actgtgattg tgaacaacaa agagaaaacc actgcagagt accaggtgtt ggtggaagga      600

gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg      660

gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa      720

ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg      780

atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg      840

atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg      900

acggaatcct tctctacacc caagttccac atcagcccca ccggaatgat catggaagga      960

gctcagctcc acattaagtg caccattcaa gtgactcacc tggcccagga gtttccagaa     1020

atcataattc agaaggacaa ggcgattgtg gcccacaaca gacatggcaa caaggctgtg     1080

tactcagtca tggccatggt ggagcacagt ggcaactaca cgtgcaaagt ggagtccagc     1140

cgcatatcca aggtcagcag catcgtggtc aacataacag aactattttc caagcccgaa     1200

ctggaatctt ccttcacaca tctggaccaa ggtgaaagac tgaacctgtc ctgctccatc     1260

ccaggagcac ctccagccaa cttcaccatc cagaaggaag atacgattgt gtcacagact     1320

caagatttca ccaagatagc ctcaaagtcg gacagtggga cgtatatctg cactgcaggt     1380

attgacaaag tggtcaagaa aagcaacaca gtccagatag tcgtatgtga aatgctctcc     1440

cagcccagga tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc     1500

cgttgcgaat cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa     1560

gttttggaga atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact     1620

gaagacgtcg aataccagtg tgttgcagat aattgccatt cccatgccaa aatgttaagt     1680

gaggttctga gggtgaaggt gatagccccg gtggatgagg tccagatttc tatcctgtca     1740

agtaaggtgg tggagtctgg agaggacatt gtgctgcaat gtgctgtgaa tgaaggatct     1800

ggtcccatca cctataagtt ttacagagaa aaagagggca aacccttcta tcaaatgacc     1860

tcaaatgcca cccaggcatt ttggaccaag cagaaggcta gcaaggaaca ggagggagag     1920

tattactgca cagccttcaa cagagccaac cacgcctcca gtgtccccag aagcaaaata     1980

ctgacagtca gagtcattct tgccccatgg aagaaaggac ttattgcagt ggttatcatc     2040

ggagtgatca ttgctctctt gatcattgcg gccaaatgtt attttctgag gaaagccaag     2100

gccaagcaga tgccagtgga aatgtccagg ccagcagtac cacttctgaa ctccaacaac     2160

gagaaaatgt cagatcccaa tatggaagct aacagtcatt acggtcacaa tgacgatgtc     2220

agaaaccatg caatgaaacc aataaatgat aataaagagc ctctgaactc agacgtgcag     2280

tacacggaag ttcaagtgtc ctcagctgag tctcacaaag atctaggaaa gaaggacaca     2340

gagacagtgt acagtgaagt ccggaaagct gtccctgatg ccgtggaaag cagatactct     2400

agaacggaag gctcccttga tggaacttag acagcaaggc cagatgcaca tccctggaag     2460

gacatccatg ttccgagaag aacagataat ccctgtattt caagacctct gtgcacttat     2520

ttatgaacct gccctgctcc cacagaacac agcaattcct caggctaagc tgccggttct     2580

taaatccatc ctgctaagtt aatgttgggt agaaagagat acagaggggc tgttgaattt     2640

cccacatacc ctccttccac caagttggaa catccttgga aattggaaga gcacaagagg     2700

agatccaggg caaggccatt gggatattct gaaacttgaa tattttgttt tgtgcagaga     2760

taaagacctt ttccatgcac cctcatacac agaaaccaat tttctttttt atactcaatc     2820

atttctagcg catggcctgg ttagaggctg gttttttctc ttttcctttg gtccttcaaa     2880

ggcttgtagt tttggctagt ccttgttctt tggaaataca cagtgctgac cagacagcct     2940

ccccctgtcc cctctatgac ctcgccctcc acaaatggga aaaccagact acttgggagc     3000

accgcctgtg aaataccaac ctgaagacac cgttcattca ggcaacgcac aaaacagaaa     3060

atgaaggtgg aacaagcaca gatgttcttc aactgttttt gtctacactc tttctctttt     3120

cctctaccat gctgaaggct gaaagacagg aagatggtgc catcagcaaa tattattctt     3180

aattgaaaac ttgaaatgtg tatgtttctt actaattttt aaaaatgtat tccttgccag     3240

ggcaggcaag gtggctcacg cctgtaatcc cagcacttca ggaggctgag gtgggcggat     3300

cacctgaggt caggagtttg agaccagcct gatgaaaccc tgtctctact aaaaatacaa     3360

gaattagccg ggcgtggtgg cgcatgcctg tagtatcagc tactcaagag gctgaggtga     3420

gattatcgct tgaacccagg aaacggaggt tgtagtgagc ggagatcgcg ccactgcact     3480

ccagcctgag tgacagagtg agaatccatc tcaaaaaaaa caaaaaacaa aattgcttgc     3540

taaagaagtg gtctcctgag gtcttaagac attcctgaca gtgtcttgag tgggtgggag     3600

agaggctgct gtcattgcgc tgtggaattt cacagatgag aaccacgcct agccaaaatc     3660

acttttcctg tttgcctcag tgacacagct gcagggaccc tcgtggatgt tgtattaaat     3720

aaatttgacc tttgctcttt gcagatctgt gaaatgttgt cttctgaggg gccacatgca     3780

tctatagtgc tgaggactcc ttgggcctct gaagtcacag agagaaccga gcaggtctat     3840

gtttttgttt tgttgttttg agacggagat tcgctcttgt tgcccgggct ggactgcagc     3900

ggcgcaacct ctgctcactg caacctccgc ctcctgggtt caagcagttc tcctgtctca     3960

gcctcccgag tagctgggat tacaggcaca tgtcaccacg cctggctaat ttttgtattt     4020

ttagtagaga tggggtttca ccacgttggc caggctgatc tcgaatgcct gacctttggt     4080

gatctgcccg ccttgtcctc atgtgtgctc cacaggcctt tgggttggga ttgcaggcgt     4140

gagccaccat gcccagccta gactcttttg acaatatgat gaaagctgtt ggttcctttc     4200

cccaacacac acacaccgag ttgtatcacg aaaatgtcat acaatttcca ggttttctga     4260

gtggtgggct cagattgagg tcaaaggatc agacgacctc taacgacctt catgtctctg     4320

ttgatgatct ggggacagcc agatcccctg tgtccaggga gttccttagt cccttgccac     4380

caccagagaa gggcaattgc cacgggagct gcaaagaccc tattcctact cctggtgcct     4440

tacttatgca gcacgactga attttttgtt ttgttttgtt ttgttgagac aggggcttgc     4500

tctgttgccc aggctggagt gcagtggcac aacaatggct caccgcagcc tcgaacccct     4560

gggctcaagc gatcctccca tctcagcttc ctgggtagct gggaccagag gcgtgagccg     4620

ccatagctgg ctaattttta attttttttt tgcagagatg aggtttcacc atggtgccca     4680

ggctggtctc gaacttctgg gctcaagtga tcctccctcc ttggcctcgc aaagtgctgg     4740

gattgcaggc atgagccacc gcccccggcc tgtggagcac acatgagttt aaaattactt     4800

tcccttctgc ctatatttcc gaggaggaaa cttcatgcgc agggatcttt cttagtggat     4860

ttaatggcta aaaggtctgt ctgaatccag gacgctggct ttagccttcc tcggcagctg     4920

ccgtaacccc ggtgtctaaa cctgaagcat cccaggagca cccactccag gagttttctc     4980

ggccgcggaa ctcattagtt agagcgccct cttgtgttct catgtggtaa tcggtcactg     5040

aaggacttaa aatggtcctt agccaacaca cagtaaaact tttccctctt ctgaccccaa     5100

gaggtcagcc acccatttca tgagcatata ctggtcgccc catcagcgtt ctctgattgg     5160

ctaactgaac ccactccccg acctagactc aagacaggcg aagtgacgct taggtcaaca     5220

ttcactcact aaagcaacga ctgtcgggcg attttgtctc ccgctggttt tggaatggtg     5280

tctggagaca tttttggttg tcacagctgg gtgggtgtgc tcccggcatc tggtgggtag     5340

aaaccaagca tgctcctaaa catcctacag gcacagaacc gtctcccacg accaagcatg     5400

atcaagtccc aaatgccaat aatggccagg ttgagaaact ctgcacagaa gcatccagtt     5460

atttgtctgt ttgctcaaca agcttgtgct catcatgctc tgtgttcctg acgctgtgct     5520

gggtgttggc ggtgggaaga ttacaagagt cacatggcag ctgtcctcct ggaaggtaca     5580

acccagtaga gatgcagact aacagagagc caattacaaa gcagtgtgac aagcgtcatg     5640

gtggaaaatt aaaagctcaa acaagggcac atgggagggg cttccaacac agactttggg     5700

ggatccagga aggtctaaga ggaaagtggg tctcaccaaa gccttgacca taggcagagg     5760

gtaccagtgg aaaaggtggg gtgaagaaca ttgaggacaa aaggaagaag tgcaggaagg     5820

ccctgaggca agggagtggg gggtgccctg gagggatggc agcagggcag tctgtcagac     5880

ccaagtggcc tccagcccta gaagccaatt agtcctcctc aaaaagctgt cactgtcccc     5940

taagaattgc tgccaggctc ccactggcct gactcagtct ttgagagtct taaggaggag     6000

gtctctgaaa ggtacacacc aagaactctc cccagcacag ctgtttttaa gactctccac     6060

cagcgtcatt ggcgtgttgg gaagaaaccc tctgccacag aggccagctt cagcctttgc     6120

ctaacaccgc aagggcaaat ggaaaggtaa acgggaagga gatgtctccc cagcaggcta     6180

tttgaggaca gtcttccctg cagaagatct caacctgggg tccacagagt ggaaatgtta     6240

gagtagggag ctaggcaaac atgagcagga caggtgaggg cccccacagg aatgtcaggc     6300

taccatcagg tgatggtcag gtggttgtta aactgtctct gtaaaataat aattggttgc     6360

agccagctcc aagcaaggac agtctctcaa tagatacaaa acaccctgat ctggtgatca     6420

gccgcttccc gataagatct caggagctgg gcaagcagcc tggagcatgc gcaccaagag     6480

gcaaaatggc ggaatttaac cagtatatga cctaccttcc tctgggaacg cacgactggt     6540

aaggggaaaa atgcctcaag tgagcatgcg cgcaacttca gtaatcacac tgtgcatgcg     6600

accccttcca agtgctggca ggtcaccaca tacgcggaca gcctgctgca agggaagaat     6660

caggggagat gagacgtaaa tcccagaact atgccaaata cataaaaccc caagttaagg     6720

gtcaggcagg gcacttagat ctctcaagtt gcctgcctga cccaagtgta gtgtacttcc     6780

ttttgttcct gctctaaaac tttttaataa actctcactc ctgctctaaa a              6831


<210>  601
<211>  738
<212>  PRT
<213>  Homo Sapiens

<400>  601

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  602
<211>  12969
<212>  DNA
<213>  Homo Sapiens

<400>  602
gaagcaccgc ctacgtcggg ctgcgtgaca atggggccgg cggcagaacg cagctgcggc       60

ggctgcgggt ctcgtggggg cggagcggtc gccgctgccg ccgcagctcg ggtcgggatt      120

tgaaagatta gaaacttcgg gtggagaggg cggcggcgtt gaatgtgtgg cggaagcgct      180

gggggtcacg gctccgcgcg ccgccggaca gccggcggcg tctccacagc atgaattacc      240

cgggccgcgg gtccccacgg agccccgagc ataacggccg aggcggcggc ggcggcgcct      300

gggagctggg ctcagacgcg aggccagcgt tcggcggcgg cgtctgctgc ttcgagcacc      360

tgcccggcgg ggacccggac gacggcgacg tgcccctggc cctgctgcgc ggggaacccg      420

ggctgcattt ggcgccgggc accgacgacc acaaccacca cctcgcgctg gacccctgcc      480

tcagtgacga gaactatgac ttcagctccg ccgagtcggg ctcctcgctg cgctactaca      540

gcgagggtga gagcggcggc ggcggcagct ccttgtcgct gcacccgccg cagcagcctc      600

cgctggtccc gacgaactcg gggggcggcg gcgcgacagg agggtccccc ggggaaagga      660

aacgtacccg gcttggcggc ccggcggccc ggcaccgcta tgaggtagtg acggagctgg      720

gcccggagga ggtacgctgg ttctacaagg aggacaagaa gacctggaag cccttcatcg      780

gctacgactc gctccgcatc gagctcgcct tccggaccct gctgcagacc acgggtgccc      840

ggccccaggg cggggaccgg gacggcgacc atgtgtgctc ccccacgggc ccagcctcca      900

gttccggaga agatgacgat gaggaccgcg cctgcggctt ctgccagagt acgacggggc      960

acgagccgga gatggtggag cttgtgaaca tcgagcctgt gtgcgtgcgg ggcggcctct     1020

acgaggtgga tgtgacccaa ggagagtgct acccggtgta ctggaaccag gctgataaaa     1080

taccagtaat gcgtggacag tggtttattg acggcacttg gcagcctcta gaagaggaag     1140

aaagtaattt aattgagcaa gaacatctca attgttttag gggccagcag atgcaggaaa     1200

atttcgatat tgaagtgtca aaatccatag atggaaaaga tgctgttcat agtttcaagt     1260

tgagtcgaaa ccatgtggac tggcacagtg tggatgaagt atatctttat agtgatgcaa     1320

caacatctaa aattgcaaga acagttaccc aaaaactggg attttctaaa gcatcaagta     1380

gtggtaccag acttcataga ggttatgtag aagaagccac attagaagac aagccatcac     1440

agactaccca tattgtattt gttgtgcatg gcattgggca gaaaatggac caaggaagaa     1500

ttatcaaaaa tacagctatg atgagagaag ctgcaagaaa aatagaagaa aggcattttt     1560

ccaaccatgc aacacatgtt gaatttctgc ctgttgagtg gcggtcaaaa cttactcttg     1620

atggagacac tgttgattcc attactcctg acaaagtacg aggtttaagg gatatgctga     1680

acagcagtgc aatggacata atgtattata ctagtccact ttatagagat gaactagtta     1740

aaggccttca gcaagagctg aatcgattgt attccctttt ctgttctcgg aatccagact     1800

ttgaagaaaa agggggtaaa gtctcaatag tatcacattc cttgggatgt gtaattactt     1860

atgacataat gactggctgg aatccagttc ggctgtatga acagttgctg caaaaggaag     1920

aagagttgcc tgatgaacga tggatgagct atgaagaacg acatcttctt gatgaactct     1980

atataactaa acgacggctg aaggaaatag aagaacggct tcacggattg aaagcatcat     2040

ctatgacaca aacacctgcc ttaaaattta aggttgagaa tttcttctgt atgggatccc     2100

cattagcagt tttcttggcg ttgcgtggca tccgcccagg aaatactgga agtcaagacc     2160

atattttgcc tagagagatt tgtaaccggt tactaaatat ttttcatcct acagatccag     2220

tggcttatag attagaacca ttaatactga aacactacag caacatttca cctgtccaga     2280

tccactggta caatacttca aatcctttac cttatgaaca tatgaagcca agctttctca     2340

acccagctaa agaacctacc tcagtttcag agaatgaagg catttcaacc ataccaagcc     2400

ctgtgacctc accagttttg tcccgccgac actatggaga atctataaca aatataggca     2460

aagcaagcat attaggggct gctagcattg gaaagggact tggaggaatg ttgttctcaa     2520

gatttggacg ttcatctaca acacagtcat ctgaaacatc aaaagactca atggaagatg     2580

agaagaagcc agttgcctca ccttctgcta ccaccgtagg gacacagacc cttccacata     2640

gcagttctgg cttcctcgat tctgcatatt tcagacttca agaatcgttc tttaatctcc     2700

cacaacttct ttttccggaa aatgtaatgc agaataaaga taatgccctc gtggagttgg     2760

atcacaggat tgattttgaa ctcagagaag gccttgtgga gagccgctat tggtcagctg     2820

tcacgtcgca tactgcctat tggtcatcct tggatgttgc cctttttctt ttaaccttca     2880

tgtataaaca tgagcacgat gatgatgcaa aacccaattt agatccaatc tgaactctct     2940

tgaaggacat gaatggccta aaactgattt tttttttttc cgttaaaatg tgtgtgtcaa     3000

gatacggaga tttcagggtt aaagtatatt tcagttttct ttagggcaac atatatttga     3060

atttaaaagc actttattta aaaaaaaaag aagttttcag ttctgaagaa gtcatttaca     3120

gtttgcatca ttttaattat gagtctgaca aaaccttctc cagagaatca agcaagacct     3180

ggatgtgaag aaggtttggg taaactgcat gtaaaggcta caaatcacaa tctgattcct     3240

cccaaatata aaggcatatg gaacataatg tattaaccaa agtatgttat aaatcaaaaa     3300

tggtcaaggt tcagcatatt ctatatgaag atcacaaggt ggtatcgttt tagatttcta     3360

tgaaggcttt catttgtaca tccctttgaa aaaatataac agatttaaaa tgttttgaat     3420

ttaacttgtt tagaaaaact aatgcttaaa acaatatttg aactactgta tttataattt     3480

attacctcta attgctttat ttcagtgtat gagacattac tgttttaatg tttgctttga     3540

acataattta agaaccagat ttattttcta tagtgataaa cccttttttc tcagaactcc     3600

atctttgtac tcttcagatg aatatataga cactgtggca tacatttttt ttcattaaaa     3660

acttatggct tcatacaaca ctagttcaat tttttaaata aactttttat tatgttacat     3720

gtacttcaga gaaagctaaa gtttctctaa acttgacacg gagtactcca taatgggtac     3780

atttcattag ctttattaga aaactagtaa atgcttttga ataggtagta tgacagctat     3840

tttaaatgta taaacatttg tgtgccaaac aacatatatg aagggatgtg atgccactaa     3900

ctagtgcaca ttgtttctca atgtgccatt gagacacaag gcacagtaag tcaggattct     3960

gaggcattgg aagggttttc ttcagctgta attgtttcca cagtgctttt catctgaggg     4020

gctcaaagtt taagagtgca ttcaataacc catgtactag cttcttgagg taagtaaata     4080

aatcttgttc tcatgttaca tgttaataca ccaaggcacc aaaacattta aagtgccatg     4140

aattagatta catcagaaat cagaaaagct tggattgagc tagtcaccgt ggttcacgcc     4200

tgtaatccca acacttcggg aggccaagat gggaggatct cttgagccca ggatttcaag     4260

accagcttgg gcaacatagt gagaccctct tctctgcaaa aactgacaaa aattagccac     4320

ttgtagtggt gtacacctgt agtcccagct actcaagagg ctgaggtggg aggatcaccc     4380

gagcccagaa gttcaaagct gcagtgagct ctgatcacac caatgcactc cagcctgggt     4440

gacagagcca gaccctgtct ctaaaaaaca aaaaagaaaa gcttgggttg aagccaggcc     4500

atattctttt atatgctgtt caatgacttg attcacatgt gaccttttag tagtttgcaa     4560

acaataataa cagaagttgc aattcataat tcagagaaat gaccatgaag ccggtgtttc     4620

cctgcttgat ttctatgttc ttggattctc acacaaaaga ggagttacct agaggggatc     4680

agtagccatc cctgttgcac acaaccctca cttctgagtg gtttccacta ggttccactt     4740

aaggtgctgt cttttcttaa cttgcaagga attgcttagc ttcccaataa tcattgtcaa     4800

actgggagca aagttggtca gctgtatctc tcacctcctc ctttcttcat aagatagtag     4860

aatctgtggc ttacttgtag gttttactta gtgcttcagt actgttggct gttttggcct     4920

tttgctgaat ttgcacaaca acataaagca cttcttttta atgtttaaaa aaaattccaa     4980

ggctccatga ccaagtatgt gactcactaa gaaacccttg ctataaaagg cttttgatga     5040

aatcttagca aagctaaatt atctctaact tagagattcc tatgaactca ggtcattttc     5100

atagcctgtt tattttgtag gtctaattta gttctcagga aaattaaact catgctatat     5160

gactgtatcg ttaaaggtac ttgagcgtat gttgctgtag gtggtatgac actcaaatgc     5220

ataagaactt gaagggattt attcttaacc actagaatat gaagagccct ttttacctga     5280

gaagagtgaa attatgtcag accttttaat ttgatatcac tgagtaaaag gtatgttcct     5340

atagccatag gaatatgtct gcttcctttt tttcatgttg agaaaacagt caaatttaac     5400

catttggagt ttatttgaat tcttggaaag agcaatattc aaaacctttt caaaaataag     5460

atattctgga ctactggatg gatgttttgt tttcagttca tttttcatca gtagagatgg     5520

tgatttcggt tttgtagtat ccttgtttct atgtctgtgc atgttaacat tggatgtatt     5580

tgtatatact taattaatat acagactgtg tgtcattctg gcttgattag aagctaagtc     5640

agttactgag taacattttg caactttatt ccagcaagta ctaaatcggc caaaaaaagt     5700

tttgtttttg ataccattaa aattttattc tctattttgt gtacatgcta tgatgattct     5760

cccaagtact gattagatca ctgaacttta gttagcttcc caagaattat taaccgttag     5820

aataagactt agattaaatc ttgctttatt tttactttaa aattagtctt gctaaggcct     5880

tatgttagtt catactttct tttcaacagt aatcttgttt ataatccagt gtttctgtgt     5940

tttaggacat aatttaaaaa tatactggat tttggccagg tgtggcagct catgcctgta     6000

atcccagcac tttgggaggc caagcaggga agattacttg agcccaagag ttgaaaacca     6060

acctggacaa catggtgaaa cccagactct acaaaaaatg caaagattag ctgggtgtgt     6120

tggcagacgc ctgtggtccc agctactcag gaggctgagg tcggtaggac tgcatgattc     6180

cgggaggtca aggcttcagt gagccaagat tgcaccactg cactccacct tgggtgacag     6240

agctggacac tgtatccaaa aaaaaaaagt atgtatttac acacacacac acacacacac     6300

acacacactg gatgttctaa taactgctct tttgtatgtg aagcaagcct taggaatctt     6360

acgttttact tctttctgtt aaacggcatc tgttatcttt tgaagtactc acactgaaca     6420

tgcttcatgc tgaatactca cgctaaaggc ctcagacatg taaacattca tccttagtct     6480

cttttttctc tgttttctca ttgggagctg aagcatccta gtctgcagaa aatttaacac     6540

accatattcc agctttgcat cacctagaca gtagacaaaa ggaaaagaaa ttgtcagtac     6600

cgtatcacag ctagtgcctc tgttcattcc agtgatagta catgagcccc ttccagtgga     6660

gtcagatcaa gccaaaagat tttcctgtaa agtctgtagt agaagacaaa tttctttttg     6720

atccattaga ttggtatttc tatcttctca gctaattaat gagtaaggca tgtggacaat     6780

cgagaaaact aatttgagtg tatgtattaa aattgctctt ctaaaaacac gtaaaatatt     6840

aaagatcaag gcagagcaaa aaagaacgta gcaatcatat actagaaaaa gaaactaagt     6900

tttgctaaac tatgtttggg ttagttgacc tctgtagcta ttctaaagtt ttctatccct     6960

tatctgtatt ccgctgtcat tcctgtgcct caagcctctg ccaggaatct gatggtactc     7020

tggctgaact taaaacataa gaatctcaaa ggtctcattt agtaaatgtt agtgctaagt     7080

tggtgacagc ctgggttata tgctttctct ttcagtcttc agtagatgct tgtgatagtt     7140

ttcaaagaac tgtaaaattt ccgggtctgt acagattttt agagatcatt taatccaacc     7200

ctgttacagt atcatgtcag catttaaata gcagtaaagg tcatgaaaag tgaagtgaaa     7260

ggcagcaaac tccatgaaaa actaaataca gtgacaactg agggaagtgg taaagtaaaa     7320

aaatattaat gatggaattt taaagctgga aggggcatag agaccattct tttctcaata     7380

atattctgca aatattaaca ggtgtcatgt cagaaactaa gtttaggaat tgacaaattc     7440

aaaaatctcc cttacagcag ggctttgaga gcctttgcta cactaaatgc tctgtgaatc     7500

tatctggtgc tgcgtggggg cctccaaatt tatttaacca tattttttaa tttggcattt     7560

acctagagaa atgctatcac atttaattcc ttcgttttac agtttcacct cctcatgtga     7620

ttccttcatt ttgtaagtga ccgattccac cctatacaat cacatggcca atgaatgaca     7680

gtcagaatta gaacctagtc ccctgattcc caaccatgtc ttataccaga ctgtttcccc     7740

taatcgatag gaaactactc ctaaagggca gaaactgcct ctctttgttt ttgtccccca     7800

acctcccctc cacacataca cctctgtaat ctgatgcttt aagctcagat taaagcatca     7860

gcaagcttta atctgacaca tggccgtagg cttgagttag cagttggtcc cttctttctt     7920

ccagactctc ataagagtac cctatcaggt ctggacagac ttccgtttat gcctcagatt     7980

caaaataccc aggaaaaaga agaagaaata caaaacaaca aaaagaaaat caagaaaaaa     8040

ataagatatc caggaaatat tttgttagtt ttctattctg gtgacaaatg caaacttaag     8100

gaaacaagtt gcacagtgtt aactaatgtt taacattcct ttccatagtg tttatgtggg     8160

ccttttatca attcatgaca aataggtcac ctccaaaact gttccaacat aggttaactc     8220

agaaatttaa aatttaagta ctatcctttt tggagactat gagaagagtt tttactattg     8280

tgttttgttt tgttttttgg tgtgtgtgtg tatgtatgtg cattccccaa aaatagtcca     8340

ttggcagatt gttagggtga acttttcctc tgcctttgtg tttgtataag ggcgggtgca     8400

tgcttagtat tgtctgctac cttatggttt ttcatttata tgtaacatgg tacaacttgc     8460

ttcctcccca cccaacagtt gtcaggatat gttggggaat attctttagg aagattacat     8520

ctggtcttct gttggagtaa gatgaaaaac aagtatgtta acacttgacc tttactgctt     8580

tctcctggaa gacattgaat atctaggagc gtcactcata ccttcccttg actgtaccca     8640

cacccactgc ggtccctgct tgatctctca aactttttgt ttccctttga gcttcatgac     8700

aaaaaattat aaccattttc tggttctaag gctgccataa tcccaacttt gccagtaaga     8760

agatggagaa tttttgctca tagggacatt tctcagaagc agctggcacc ataactctcc     8820

tgagaccctt gtttcctttc tttcagctcc tatgacttct tatgttcact ctctctaaca     8880

ctactaaatg ttgtcaatga ctgcaatcac aactctttga aggcaggctt tttcttttcc     8940

tttgttacct cttattttca atagccaaag caggttagtt ttctcagaat cttcagtttt     9000

actgaagcat gcattatttc tgttttctct ctgcagtgat cagtttggat gacagaaact     9060

ttaaactttt attctggcat tgtccagttc tgattttctc agctggaact ggtgcatgca     9120

catttaataa tttcaaagaa gtgagaggta aatgttttct cctgcattat actgtgtttc     9180

tctagctgaa ttgatccgtt tgttatcttg ctcacccgaa acaagtagtt gtgccctaca     9240

gtgagcaacc tcagactagg ctgttctaag cattctggag aaaataatcc tcatcataca     9300

gtttgtggta actcttccaa aaagtttatg aaaattgaaa gatctcccta tgcatcagct     9360

gtggctgcca cattccgttc tactaggaag gctagtggcc acaactccct ctagaacatc     9420

agaggataaa gtacacttat atattagaaa agacaggcat attctgatta tggttcattc     9480

acaatttctc agtccagggt tcagtcagtg accatagctc tgaggtcttc aggctaactc     9540

caagaacccg tgccagatag aaacctactc ctactacctt tccactcacc ttcccattcc     9600

cccacctttg ctaccaaagt gactttaaaa gtcgagtttt aggtgtttgt ttttttaaca     9660

gtctaggaat ttcagtgcaa ttccgtgagg tggtgctgac cttagatgag aaatacgtgg     9720

ccaggctata aggactacat gtagaattga gatgggacag tgtacgtatg gactgtgagg     9780

ggaaagaaaa ggtaaatgtg tgaaaggaaa gagattggtg catggtcatg acagtctgac     9840

agcttagaca tttcagaggc attgtttatg agaaagggga tagggacaca taggtctgat     9900

gacaaccaaa gccctttgat gatgccatct gtcactcaag gctccccaca gcctgcccaa     9960

cctgactctc ctgcctgctt ctccactgcc taccttcaac aatcaaacta tatttttgtt    10020

acagcaaact acattccatt tgcctttaaa tgcttgcatt ttagttattg tactggctac    10080

ctgtttttgt ctgcccagca tcctgtttcc cctccttttg gatcctctcc tagccaattc    10140

catgtcttga atcctttcct gctccttgtt aaaattattt tctgctttgt gtgagtccct    10200

gtaagcacca gcagctcaat cagcactgtc tgtaccatgg tcaagagatg agtacatgac    10260

tcaggtcaga ccttatttcc caccccataa gccacaatga ttagacaaga aataggcaca    10320

gaaccctaac tagatagggc agaagccttc cataggattt tatttgctgg ccctgaaatg    10380

caggtagcct tctatggctg ttaaacacaa tccagtggca catggggtga tatgaggatg    10440

gagccatcca tggcaaaact ccaccctttc ctgtgacatg gattatgtgc atctgccatg    10500

aaaaggaagc atacacaaga aatgagccaa gagttcctgg agaactgaag caagtatcac    10560

ctccagatca gttgtacttt tatttgctta cactattctg aggtgggtct ctgtctcttg    10620

gatccaaaag agttcaaatt aataatcatt tgacaaaaaa ttacctccac attcctaatg    10680

aagttgtctt tgaagataat gtcttgtgat cccctggttg aagttaatta ctgcttgtga    10740

gcccccatta acaacgtgtt cctttcccca ttgcttgctt gtatcagctt tgctgaagat    10800

ctattggctg taggtgtgca gctttatttc tgtgttctct attgtgttcc attggtctac    10860

gtgtctgtta ttgtaccagt gccgtgctgt tttggttact gtggtcttat agtttgaagc    10920

cacatctgtg tgatgctgct ggctttgttc tttctgcttt gggttgcttt ggctattcag    10980

gctctttctt tggttccatc tgaattttag aatagttgtt ttctaattct gtgaaaatgt    11040

tccaacctct gtgaaaaatg aggttggtag tttgatagga cagcattgat tctgtaaatt    11100

gctttgggca gtatggccat ttttaaacta tattgattct tccaatccat gaacatggaa    11160

tgtttttcca ttttttggtt tcatccctga tttctttctg ccatgttttg tagttctcct    11220

tgtagagatc tttcacctcc ttggttaggt gtatttttaa gtatttcagt ttttttatgg    11280

ctattgtaaa tggtattggg ttcttgattt gctctcagct tgaacgttat tggtgtatag    11340

aaatgctcct aatttttgtg cattgatttt gtatcctgaa acttgactaa agttgtttat    11400

cagtctagga gcttttggca gagtcttcgg ggttttctag gtataaaatc atatcagcga    11460

agagagctag tttgatttct tttcccagtt ggatgccttt tatttatttc tcttgcctga    11520

ttgctctaag ttgaatggga gcgatgagac tgggcatcct cttcttattc cagttctcag    11580

aaggaatagt tccagctttt gctcatccag tatgatgtct gtgggttggt tgtagatggc    11640

tcttattatt ttgagatatg ttcctttgat acctagtctg ttgaggggtt ttatcatgag    11700

ggatgttgga ttttatccgt attcaataaa tggtgttggg ataactggct agccctatgc    11760

agaagaatga aactggaccc cccacctttc accgtatatg aaaattaact caagatggat    11820

taaagattta aatgtaagac ctcaaactgt aaaaatccta gaagaaaacc taggaaatac    11880

ccttatcaac atcagccttg gcaaagaact tttggctaag tccccaaagg caattgcaac    11940

aaaacagaaa ttggcaagtg gggacctaat taaagcactc tgcacagcaa aagacactat    12000

caacagagta aacagacaac atacagaatt ggagaaaata tttgcaaact agacatccaa    12060

caaagatctg acatccagaa tcaataagga acttaacaag caaaaaacaa ccccattaaa    12120

aaatgggtga aggacatgaa cagacacttc tcaaaagaag acatacaagc aatcaacaaa    12180

cgtgaaaaaa tgctcatcac taatcatcag agaaatgcaa atcaaaacca caataagata    12240

ccatctcaca ccagttagaa tggctattgt aaagaagtct aataacatgc cagtaaggtt    12300

tcagagaaaa gagaacattt atacactgtt gtgggaatgt aaattagttc agtcactgtg    12360

gaaagcagtt tggagatttc tcaaataact taaaacagat ctaccattca acccagcata    12420

tgggtttatt tcccaaaagg aaataaatcc ttctaccaaa aacacatatg gtcatcacag    12480

tgctattcac agtagcaaag acagatcaac gtggctgccc atcaacagtg gactggataa    12540

agaaaatgtg gtacatataa atcatggagt attaggcagc cataaaaaga acaaaatcat    12600

gtcctttgca gccagccaca tggatacagc tggaagccat aatctaagca aattaagaac    12660

agaaaaccaa gtactgcatg ttctaacaaa tgggagctaa atattgagta cctcaggatg    12720

caaaggtggg aacaacagac actgcagact ggaacactgt gggtgaggag ggcagaagga    12780

taggttgaaa aactacctat tgggtactat gctcactacc tgggtgatgg gatctgtacc    12840

tcaaacctca gcatcacaca atataccctt gtaacaaact tgcacattta cccactgttt    12900

ctaaatgaaa agttgaaata ttttttatta aaaaacacaa aagcaatatg tttctcaata    12960

aaaaaaaaa                                                            12969


<210>  603
<211>  900
<212>  PRT
<213>  Homo Sapiens

<400>  603

Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu Arg Lys 
    130                 135                 140                 


Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu Val Val 
145                 150                 155                 160 


Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu Asp Lys 
                165                 170                 175     


Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile Glu Leu 
            180                 185                 190         


Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln Gly Gly 
        195                 200                 205             


Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala Ser Ser 
    210                 215                 220                 


Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile Glu Pro 
                245                 250                 255     


Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu 
            260                 265                 270         


Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg 
        275                 280                 285             


Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu 
    290                 295                 300                 


Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln 
305                 310                 315                 320 


Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys 
                325                 330                 335     


Asp Ala Val His Ser Phe Lys Leu Ser Arg Asn His Val Asp Trp His 
            340                 345                 350         


Ser Val Asp Glu Val Tyr Leu Tyr Ser Asp Ala Thr Thr Ser Lys Ile 
        355                 360                 365             


Ala Arg Thr Val Thr Gln Lys Leu Gly Phe Ser Lys Ala Ser Ser Ser 
    370                 375                 380                 


Gly Thr Arg Leu His Arg Gly Tyr Val Glu Glu Ala Thr Leu Glu Asp 
385                 390                 395                 400 


Lys Pro Ser Gln Thr Thr His Ile Val Phe Val Val His Gly Ile Gly 
                405                 410                 415     


Gln Lys Met Asp Gln Gly Arg Ile Ile Lys Asn Thr Ala Met Met Arg 
            420                 425                 430         


Glu Ala Ala Arg Lys Ile Glu Glu Arg His Phe Ser Asn His Ala Thr 
        435                 440                 445             


His Val Glu Phe Leu Pro Val Glu Trp Arg Ser Lys Leu Thr Leu Asp 
    450                 455                 460                 


Gly Asp Thr Val Asp Ser Ile Thr Pro Asp Lys Val Arg Gly Leu Arg 
465                 470                 475                 480 


Asp Met Leu Asn Ser Ser Ala Met Asp Ile Met Tyr Tyr Thr Ser Pro 
                485                 490                 495     


Leu Tyr Arg Asp Glu Leu Val Lys Gly Leu Gln Gln Glu Leu Asn Arg 
            500                 505                 510         


Leu Tyr Ser Leu Phe Cys Ser Arg Asn Pro Asp Phe Glu Glu Lys Gly 
        515                 520                 525             


Gly Lys Val Ser Ile Val Ser His Ser Leu Gly Cys Val Ile Thr Tyr 
    530                 535                 540                 


Asp Ile Met Thr Gly Trp Asn Pro Val Arg Leu Tyr Glu Gln Leu Leu 
545                 550                 555                 560 


Gln Lys Glu Glu Glu Leu Pro Asp Glu Arg Trp Met Ser Tyr Glu Glu 
                565                 570                 575     


Arg His Leu Leu Asp Glu Leu Tyr Ile Thr Lys Arg Arg Leu Lys Glu 
            580                 585                 590         


Ile Glu Glu Arg Leu His Gly Leu Lys Ala Ser Ser Met Thr Gln Thr 
        595                 600                 605             


Pro Ala Leu Lys Phe Lys Val Glu Asn Phe Phe Cys Met Gly Ser Pro 
    610                 615                 620                 


Leu Ala Val Phe Leu Ala Leu Arg Gly Ile Arg Pro Gly Asn Thr Gly 
625                 630                 635                 640 


Ser Gln Asp His Ile Leu Pro Arg Glu Ile Cys Asn Arg Leu Leu Asn 
                645                 650                 655     


Ile Phe His Pro Thr Asp Pro Val Ala Tyr Arg Leu Glu Pro Leu Ile 
            660                 665                 670         


Leu Lys His Tyr Ser Asn Ile Ser Pro Val Gln Ile His Trp Tyr Asn 
        675                 680                 685             


Thr Ser Asn Pro Leu Pro Tyr Glu His Met Lys Pro Ser Phe Leu Asn 
    690                 695                 700                 


Pro Ala Lys Glu Pro Thr Ser Val Ser Glu Asn Glu Gly Ile Ser Thr 
705                 710                 715                 720 


Ile Pro Ser Pro Val Thr Ser Pro Val Leu Ser Arg Arg His Tyr Gly 
                725                 730                 735     


Glu Ser Ile Thr Asn Ile Gly Lys Ala Ser Ile Leu Gly Ala Ala Ser 
            740                 745                 750         


Ile Gly Lys Gly Leu Gly Gly Met Leu Phe Ser Arg Phe Gly Arg Ser 
        755                 760                 765             


Ser Thr Thr Gln Ser Ser Glu Thr Ser Lys Asp Ser Met Glu Asp Glu 
    770                 775                 780                 


Lys Lys Pro Val Ala Ser Pro Ser Ala Thr Thr Val Gly Thr Gln Thr 
785                 790                 795                 800 


Leu Pro His Ser Ser Ser Gly Phe Leu Asp Ser Ala Tyr Phe Arg Leu 
                805                 810                 815     


Gln Glu Ser Phe Phe Asn Leu Pro Gln Leu Leu Phe Pro Glu Asn Val 
            820                 825                 830         


Met Gln Asn Lys Asp Asn Ala Leu Val Glu Leu Asp His Arg Ile Asp 
        835                 840                 845             


Phe Glu Leu Arg Glu Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val 
    850                 855                 860                 


Thr Ser His Thr Ala Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu 
865                 870                 875                 880 


Leu Thr Phe Met Tyr Lys His Glu His Asp Asp Asp Ala Lys Pro Asn 
                885                 890                 895     


Leu Asp Pro Ile 
            900 


<210>  604
<211>  1999
<212>  DNA
<213>  Homo Sapiens

<400>  604
ccggagcccc gccagagccc gacttcagcc ccagccagat cccgcgtcaa cggaggcgga       60

acggcggacc ccgtaccctg gcagcatcgg agcaccggcg ggtgaaggca aggtccctgg      120

actggtcata tacctcttgt ggccctggca gaatcaagat gaggccctgt catgcctccc      180

cagtgaggcc tacagtctga gcagacagca tggcctgcca ctggcagtga acaccatgtc      240

tgcaggaggt ggccgggcct ttgcttggca agtgttcccc cccatgccca cttgccgggt      300

ctatggcaca gtggcacacc aagatgggca cctgctggtg ttggggggtt gtggccgggc      360

tggactgccc ctggacactg ctgagacact ggacatggcc tcgcacacat ggctggcact      420

ggcacccctg cccactgccc gggctggtgc agctgcggta gttctgggca agcaggtgct      480

agtggtgggt ggtgtggatg aggtccagag cccggtagct gctgtagagg ccttcctgat      540

ggatgagggc cgctgggagc gtcgggccac cctccctcaa gcagccatgg gggttgcaac      600

tgtggagaga gatggtatgg tgtatgctct ggggggaatg ggccctgaca cggcccccca      660

ggcccaggta cgtgtgtatg agccccgtcg ggactgctgg ctttcgctac cctccatgcc      720

cacaccctgc tatggggcct ccaccttcct gcacgggaac aagatctatg tcctgggggg      780

ccgccagggc aagctcccgg tgactgcttt tgaagccttt gatctggagg cccgtacatg      840

gacccggcat ccaagcctac ccagccgtcg ggcctttgct ggctgcgcca tggctgaagg      900

cagcgtcttt agcctgggtg gcctgcagca gcctgggccc cacaacttct actctcgccc      960

acactttgtc aacactgtgg agatgtttga cctggagcat gggtcctgga ccaaattgcc     1020

ccgcagcctg cgcatgaggg ataagagggc agactttgtg gttgggtccc ttgggggcca     1080

cattgtggcc attgggggcc ttggaaacca gccatgtcct ttgggctctg tggagagctt     1140

tagccttgca cggcggcgct gggaggcatt gcctgccatg cccactgccc gctgctcctg     1200

ctctagtctg caggctgggc cccggctgtt tgttattggg ggtgtggccc agggccccag     1260

tcaagccgtg gaggcactgt gtctgcgtga tggggtctga aggcttggtg ggagctgtcc     1320

actggagcag ctcattgcca gaggcagcta tttctatggc tccttttgct gctgaggaca     1380

ctcactgtgg ctctgtggga tgagagaggc atgggggtga gcacttgaaa cactgccttg     1440

gggccttggg ttaggggagc ctttgtcttt agtgcaggac acacatatgc ttacacctac     1500

ctttatcacc attcgttcat gaatcatgcc tagctccatc cttgccctgg gacctactag     1560

gccttccatc caactgggaa atggggagaa gcaaagctgg cctcatgctc ttcagggtca     1620

gttcctatct ggagttgacc aggcctaccc cagttgccat tcctgaaaaa tctcagctgc     1680

caggctgcct ttagggtccc tgcagaccca ggagagttga gagggtgggg gacacagaga     1740

gaatagagag gatgtgggaa ctgccagagg gccggagcgc aggagttcaa gtggaggaat     1800

gctggctttg agccctctac actgctggtt gtatgacctt ggacaagtca cttcacctct     1860

ctgtgcctca gcatcctcat ctataaatgg ggatctctga aaccttccta ccctacctac     1920

ctcacagggc tgttgtgagg acccagggag tttggatgtg gaagtaaaag tgctgctaaa     1980

acctaaaaaa aaaaaaaaa                                                  1999


<210>  605
<211>  354
<212>  PRT
<213>  Homo Sapiens

<400>  605

Met Ser Ala Gly Gly Gly Arg Ala Phe Ala Trp Gln Val Phe Pro Pro 
1               5                   10                  15      


Met Pro Thr Cys Arg Val Tyr Gly Thr Val Ala His Gln Asp Gly His 
            20                  25                  30          


Leu Leu Val Leu Gly Gly Cys Gly Arg Ala Gly Leu Pro Leu Asp Thr 
        35                  40                  45              


Ala Glu Thr Leu Asp Met Ala Ser His Thr Trp Leu Ala Leu Ala Pro 
    50                  55                  60                  


Leu Pro Thr Ala Arg Ala Gly Ala Ala Ala Val Val Leu Gly Lys Gln 
65                  70                  75                  80  


Val Leu Val Val Gly Gly Val Asp Glu Val Gln Ser Pro Val Ala Ala 
                85                  90                  95      


Val Glu Ala Phe Leu Met Asp Glu Gly Arg Trp Glu Arg Arg Ala Thr 
            100                 105                 110         


Leu Pro Gln Ala Ala Met Gly Val Ala Thr Val Glu Arg Asp Gly Met 
        115                 120                 125             


Val Tyr Ala Leu Gly Gly Met Gly Pro Asp Thr Ala Pro Gln Ala Gln 
    130                 135                 140                 


Val Arg Val Tyr Glu Pro Arg Arg Asp Cys Trp Leu Ser Leu Pro Ser 
145                 150                 155                 160 


Met Pro Thr Pro Cys Tyr Gly Ala Ser Thr Phe Leu His Gly Asn Lys 
                165                 170                 175     


Ile Tyr Val Leu Gly Gly Arg Gln Gly Lys Leu Pro Val Thr Ala Phe 
            180                 185                 190         


Glu Ala Phe Asp Leu Glu Ala Arg Thr Trp Thr Arg His Pro Ser Leu 
        195                 200                 205             


Pro Ser Arg Arg Ala Phe Ala Gly Cys Ala Met Ala Glu Gly Ser Val 
    210                 215                 220                 


Phe Ser Leu Gly Gly Leu Gln Gln Pro Gly Pro His Asn Phe Tyr Ser 
225                 230                 235                 240 


Arg Pro His Phe Val Asn Thr Val Glu Met Phe Asp Leu Glu His Gly 
                245                 250                 255     


Ser Trp Thr Lys Leu Pro Arg Ser Leu Arg Met Arg Asp Lys Arg Ala 
            260                 265                 270         


Asp Phe Val Val Gly Ser Leu Gly Gly His Ile Val Ala Ile Gly Gly 
        275                 280                 285             


Leu Gly Asn Gln Pro Cys Pro Leu Gly Ser Val Glu Ser Phe Ser Leu 
    290                 295                 300                 


Ala Arg Arg Arg Trp Glu Ala Leu Pro Ala Met Pro Thr Ala Arg Cys 
305                 310                 315                 320 


Ser Cys Ser Ser Leu Gln Ala Gly Pro Arg Leu Phe Val Ile Gly Gly 
                325                 330                 335     


Val Ala Gln Gly Pro Ser Gln Ala Val Glu Ala Leu Cys Leu Arg Asp 
            340                 345                 350         


Gly Val 
        


<210>  606
<211>  5679
<212>  DNA
<213>  Homo Sapiens

<400>  606
gcttttctcc ttggcatggt cacggaatgg atacctgttt gatcttcctg cactgctgag       60

aaatcttcct tttgggggag aggattaagt ctgggttgag gtaggccacc tgttgagacc      120

tggtgaaaga tcaggtataa taatgttctg cagtgaaaag aaattgcgtg aagtggaacg      180

gatagtgaaa gccaatgacc gtgaatataa tgaaaagttc cagtatgcgg ataatcgtat      240

ccacacatcg aaatataata ttctcacctt cttgccaatt aatttatttg aacagttcca      300

aagagtggca aatgcctatt ttctttgcct tctgatttta cagctaattc cagaaatttc      360

ctccttgacc tggtttacca ccattgtgcc tttggtcctg gtgataacta tgacagctgt      420

caaagatgcc acagatgact attttcgcca caagagtgat aatcaagtga ataatcggca      480

gtctgaagtg ctcatcaaca gcaaactgca gaatgaaaaa tggatgaatg tcaaagtggg      540

agacatcatt aaattagaaa ataaccaatt tgttgctgct gatttacttc tcctatcaag      600

tagtgagcca catggtctct gttatgttga aactgctgag cttgatgggg aaacgaacct      660

aaaagtccgc catgcactat cagttacttc agaacttgga gcagatatca gcagacttgc      720

agggtttgat gggattgttg tctgtgaggt gcctaacaac aagttagata aattcatggg      780

aatcctttct tggaaagaca gcaagcattc cctcaacaat gagaagataa tcctgagagg      840

ctgcatcctg agaaatacca gctggtgttt tggaatggtt atttttgcag gtcctgacac      900

taaactaatg cagaatagtg gtaagacaaa gtttaaaagg acaagcattg atagattgat      960

gaatactcta gtactatgga tttttgggtt tctgatatgc ttgggaatta ttcttgcaat     1020

aggaaattca atctgggaga gtcaaactgg ggaccaattc agaactttcc tcttttggaa     1080

tgaaggagag aagagctctg tgttctccgg attcttaaca ttctggtcat atattattat     1140

tctcaataca gttgtaccca tttccttata tgtgagtgtg gaagtaattc gtctaggaca     1200

cagttatttt ataaactggg accggaagat gtattattct cgaaaagcaa tacctgcagt     1260

ggctcgaacg accacgctca atgaggaact ggggcagatt gagtacattt tctccgacaa     1320

aacgggtacc ctcactcaaa acatcatgac ctttaaaaga tgttccatta atgggagaat     1380

ctatggtgaa gtacatgatg acctggatca gaagacagaa ataactcagg aaaaagagcc     1440

tgtggatttc tcagtcaaat ctcaagcgga tagagaattt cagttctttg accaccatct     1500

gatggaatcc attaaaatgg gtgatcccaa agttcatgaa ttccttaggt tacttgctct     1560

ctgccacact gtaatgtcag aagagaatag cgcaggagag ctgatttacc aagttcagtc     1620

acctgatgaa ggggctctag tgactgccgc tagaaatttt gggttcattt ttaaatcccg     1680

gaccccagag accataacaa tagaagaatt gggaacacta gttacttatc aattacttgc     1740

ctttttggat ttcaacaaca ccagaaaaag gatgtctgtc atagttcgaa acccagaagg     1800

acagataaag ctttattcca aaggagcaga tactattctg tttgaaaaac ttcatccttc     1860

caatgaagtc cttttgtctt tgacgtcaga ccacctcagt gaatttgcag gggaaggcct     1920

tcggaccttg gccatcgcat acagagacct ggatgacaag tactttaaag agtggcataa     1980

gatgcttgaa gatgcgaatg ctgccacaga agagagggat gaacgaatag ctgggctata     2040

tgaagaaatt gaaagagatt tgatgctact aggtgccact gctgtagaag ataagttaca     2100

ggagggtgtt attgaaacag ttacaagttt atcactagcc aatattaaga tctgggtcct     2160

aacaggagac aaacaagaaa ctgccatcaa catcggttat gcctgcaaca tgctgactga     2220

cgacatgaat gatgtgtttg tgatagcagg gaataatgct gtggaagtga gagaagaact     2280

caggaaagca aaacaaaatt tgtttggaca aaacagaaat ttttccaatg gccatgtagt     2340

ttgtgaaaaa aagcagcagc tggagttgga ttctattgta gaagaaacca taacaggaga     2400

ttatgcctta atcataaatg gccacagttt ggctcatgcc ctagaaagtg atgtcaagaa     2460

tgatctccta gaacttgctt gcatgtgtaa gactgtaatt tgctgcaggg tcactccact     2520

ccagaaagcc caagtggtag agctggtgaa gaagtacaga aatgctgtta ctttggccat     2580

tggtgatgga gccaatgatg tcagcatgat taaaagtgct cacattggtg ttggcatcag     2640

cggccaggaa ggattgcaag cagtcttagc cagcgactat tcatttgcac agtttagata     2700

tctccaaagg cttctccttg ttcatggaag gtggtcttat ttccgaatgt gcaaattctt     2760

atgctatttc ttctataaga attttgcatt tacacttgtg catttctggt ttggtttctt     2820

ctgtggtttc tcagcccaga ctgtttatga ccagtggttc atcacccttt ttaacattgt     2880

ttacacatca ctgcctgttt tagccatggg gatttttgac caggatgtga gtgaccagaa     2940

cagcgtggac tgtccccagc tctacaaacc aggacagctg aatctgcttt ttaacaagcg     3000

taaatttttc atttgcgtgt tgcatggaat ctacacctca ttagtccttt tcttcatccc     3060

ctatggggcc ttttacaacg tggctggaga agatgggcaa catattgctg actaccagtc     3120

ctttgcagtt accatggcca catctttggt cattgtggtc agtgtgcaga tagccttgga     3180

taccagttac tggactttca ttaatcacgt cttcatctgg gggagcattg ccatttattt     3240

ctccatttta tttacaatgc acagtaatgg catctttggc atcttcccaa accagtttcc     3300

atttgttggt aatgcacgac attccctgac ccagaagtgc atctggcttg taattctctt     3360

aacaacagtg gcttcagtta tgccagtggt ggcattcaga tttttgaagg tggatttata     3420

cccaaccctg agtgatcaga tccgccggtg gcagaaggct caaaagaagg caaggcctcc     3480

aagtagccga aggcctcgga cccgcaggtc aagctcaaga aggtctggat atgcttttgc     3540

tcaccaagaa ggctatggag agcttatcac atctggaaaa aatatgcgag ctaaaaatcc     3600

acccccaaca tcagggctgg aaaagacaca ttataatagc actagctgga ttgaaaattt     3660

atgtaagaaa accacagaca ccgtgagcag ctttagccag gataaaacag tgaaactgtg     3720

agtcaatatg aatttaaacc acgtagttat cttttcactt caggtggagc tgaaattctg     3780

ctggctccag agtttgagat ttgaggcaag aggtggggca ggcagattgc ctcacttaac     3840

ttaaatctgc ggcagacaac tgccagtgcc catcaaacag gagtgtgcgc tatggaaaac     3900

caggccagag ggtcactgtc tggtttgtga tttggtggac aaaacactcg ctgttacaag     3960

tacagatttt tttttttttt aaatcaacct agataccaat tgacctgaac tttagaatct     4020

tatttatgga gaaaaacttg taaagctgca tattcactga atggatcctc aggcggataa     4080

aagggtgcat tttaaaggta tatatccaag ctgaaaagca tgcctattga cagataaaca     4140

tgtatctgta agatcagcct ttcccaaggt atacttttaa aatttaaagc gtgtactgtg     4200

ttgctttcag actgagttgc atgtcactct ttagtcttga tatctacctg tctgttcagc     4260

caggacaaca aatggcttcc aagcctgaag aatacaaaag tgtgcttgtg tttctcattt     4320

ttataccagt ctagggacaa aggagactga acatctttgc agcaggatag gctggtaatt     4380

tgatcaaatt tattcaaaaa gctctcagtc tgtgtcatgt aaggacatgc ttatgaaatg     4440

tgagagaggc tcgccactaa gtattctaaa tacttttcaa tggcttttct aacaacctca     4500

gtagtaattt gctgagcatc atccagacca ttaatagaat cagcaaagca ctggaatttc     4560

acactttaat gataatattc cacatagtct atgggcaaat attttcaaca tttccaattt     4620

ttaaagcttc agaattgaag ccaaacaaat taataaataa ttgttttaat tactatttaa     4680

aaactcaggt ttagattgtt taaaattagt tgcttttgat actcagctgt catgtttata     4740

attcaaacat gtagtaaaca tatgtaggta aggttgtttt tttggagatg ttgcagctca     4800

aatttcagtc cacatatgaa tcatcagtgt attttccata aagtgattcg ggcatatttg     4860

tgtgaaaacc tcagttctgt cacttcttac ctctataaac ttggacgata atgtgccttc     4920

tctgagactc agtttcttcc tctgtaaaat gaggacatac tacctacctc atgtggttgg     4980

ttgatgattg tctgtcaaag cacaaactct gaaattatta aaaacataat tatttcataa     5040

acagatgagt taagttccag ttaactcaac atcagtataa cagagcaatt ggaagagaat     5100

atgaaaaaac tggaatctaa atagtcagtg aggaaggctt tgataaaatg aaattgccag     5160

aaagatataa aactggttag ggtcctacag ggaaataaaa ttataaccgt ggaggtacat     5220

ttctctacca gaaagcaaaa ataaagcatc atgtcttaat ggttttctac aaatcaactt     5280

ctaattctac agagtcctta atctggtccc tattaaattc ttggtcagac aaagttacat     5340

ttcccaagag agtcaggtga cacttgagtg agtttgatgg ataatgagct aatgtgatat     5400

ctataggtca caatttttta aaaccaaaat tttcaagtct gggataatct ttcctaaatg     5460

ggatcaaatg aaataatatg tgtaaaagag tcaaatgcag tcctttacca tagtaactgc     5520

ctatggacgt tgtctttccc ttacatgcct gcctacactt aaccagatgt tggttttcaa     5580

tgtctaattt gtcattagtt tcaccacatt tgctcacttt ttgtaacatt tttgcaagat     5640

ttgaaaactt tcagtaaatg ttttggcact attggtaaa                            5679


<210>  607
<211>  1192
<212>  PRT
<213>  Homo Sapiens

<400>  607

Met Phe Cys Ser Glu Lys Lys Leu Arg Glu Val Glu Arg Ile Val Lys 
1               5                   10                  15      


Ala Asn Asp Arg Glu Tyr Asn Glu Lys Phe Gln Tyr Ala Asp Asn Arg 
            20                  25                  30          


Ile His Thr Ser Lys Tyr Asn Ile Leu Thr Phe Leu Pro Ile Asn Leu 
        35                  40                  45              


Phe Glu Gln Phe Gln Arg Val Ala Asn Ala Tyr Phe Leu Cys Leu Leu 
    50                  55                  60                  


Ile Leu Gln Leu Ile Pro Glu Ile Ser Ser Leu Thr Trp Phe Thr Thr 
65                  70                  75                  80  


Ile Val Pro Leu Val Leu Val Ile Thr Met Thr Ala Val Lys Asp Ala 
                85                  90                  95      


Thr Asp Asp Tyr Phe Arg His Lys Ser Asp Asn Gln Val Asn Asn Arg 
            100                 105                 110         


Gln Ser Glu Val Leu Ile Asn Ser Lys Leu Gln Asn Glu Lys Trp Met 
        115                 120                 125             


Asn Val Lys Val Gly Asp Ile Ile Lys Leu Glu Asn Asn Gln Phe Val 
    130                 135                 140                 


Ala Ala Asp Leu Leu Leu Leu Ser Ser Ser Glu Pro His Gly Leu Cys 
145                 150                 155                 160 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Val Arg 
                165                 170                 175     


His Ala Leu Ser Val Thr Ser Glu Leu Gly Ala Asp Ile Ser Arg Leu 
            180                 185                 190         


Ala Gly Phe Asp Gly Ile Val Val Cys Glu Val Pro Asn Asn Lys Leu 
        195                 200                 205             


Asp Lys Phe Met Gly Ile Leu Ser Trp Lys Asp Ser Lys His Ser Leu 
    210                 215                 220                 


Asn Asn Glu Lys Ile Ile Leu Arg Gly Cys Ile Leu Arg Asn Thr Ser 
225                 230                 235                 240 


Trp Cys Phe Gly Met Val Ile Phe Ala Gly Pro Asp Thr Lys Leu Met 
                245                 250                 255     


Gln Asn Ser Gly Lys Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg Leu 
            260                 265                 270         


Met Asn Thr Leu Val Leu Trp Ile Phe Gly Phe Leu Ile Cys Leu Gly 
        275                 280                 285             


Ile Ile Leu Ala Ile Gly Asn Ser Ile Trp Glu Ser Gln Thr Gly Asp 
    290                 295                 300                 


Gln Phe Arg Thr Phe Leu Phe Trp Asn Glu Gly Glu Lys Ser Ser Val 
305                 310                 315                 320 


Phe Ser Gly Phe Leu Thr Phe Trp Ser Tyr Ile Ile Ile Leu Asn Thr 
                325                 330                 335     


Val Val Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly 
            340                 345                 350         


His Ser Tyr Phe Ile Asn Trp Asp Arg Lys Met Tyr Tyr Ser Arg Lys 
        355                 360                 365             


Ala Ile Pro Ala Val Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu Gly 
    370                 375                 380                 


Gln Ile Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
385                 390                 395                 400 


Ile Met Thr Phe Lys Arg Cys Ser Ile Asn Gly Arg Ile Tyr Gly Glu 
                405                 410                 415     


Val His Asp Asp Leu Asp Gln Lys Thr Glu Ile Thr Gln Glu Lys Glu 
            420                 425                 430         


Pro Val Asp Phe Ser Val Lys Ser Gln Ala Asp Arg Glu Phe Gln Phe 
        435                 440                 445             


Phe Asp His His Leu Met Glu Ser Ile Lys Met Gly Asp Pro Lys Val 
    450                 455                 460                 


His Glu Phe Leu Arg Leu Leu Ala Leu Cys His Thr Val Met Ser Glu 
465                 470                 475                 480 


Glu Asn Ser Ala Gly Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu 
                485                 490                 495     


Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser 
            500                 505                 510         


Arg Thr Pro Glu Thr Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr 
        515                 520                 525             


Tyr Gln Leu Leu Ala Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met 
    530                 535                 540                 


Ser Val Ile Val Arg Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys 
545                 550                 555                 560 


Gly Ala Asp Thr Ile Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val 
                565                 570                 575     


Leu Leu Ser Leu Thr Ser Asp His Leu Ser Glu Phe Ala Gly Glu Gly 
            580                 585                 590         


Leu Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp Asp Lys Tyr Phe 
        595                 600                 605             


Lys Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala Ala Thr Glu Glu 
    610                 615                 620                 


Arg Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile Glu Arg Asp Leu 
625                 630                 635                 640 


Met Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Glu Gly Val 
                645                 650                 655     


Ile Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile Lys Ile Trp Val 
            660                 665                 670         


Leu Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ala Cys 
        675                 680                 685             


Asn Met Leu Thr Asp Asp Met Asn Asp Val Phe Val Ile Ala Gly Asn 
    690                 695                 700                 


Asn Ala Val Glu Val Arg Glu Glu Leu Arg Lys Ala Lys Gln Asn Leu 
705                 710                 715                 720 


Phe Gly Gln Asn Arg Asn Phe Ser Asn Gly His Val Val Cys Glu Lys 
                725                 730                 735     


Lys Gln Gln Leu Glu Leu Asp Ser Ile Val Glu Glu Thr Ile Thr Gly 
            740                 745                 750         


Asp Tyr Ala Leu Ile Ile Asn Gly His Ser Leu Ala His Ala Leu Glu 
        755                 760                 765             


Ser Asp Val Lys Asn Asp Leu Leu Glu Leu Ala Cys Met Cys Lys Thr 
    770                 775                 780                 


Val Ile Cys Cys Arg Val Thr Pro Leu Gln Lys Ala Gln Val Val Glu 
785                 790                 795                 800 


Leu Val Lys Lys Tyr Arg Asn Ala Val Thr Leu Ala Ile Gly Asp Gly 
                805                 810                 815     


Ala Asn Asp Val Ser Met Ile Lys Ser Ala His Ile Gly Val Gly Ile 
            820                 825                 830         


Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala Ser Asp Tyr Ser Phe 
        835                 840                 845             


Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp 
    850                 855                 860                 


Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys Asn 
865                 870                 875                 880 


Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly Phe Phe Cys Gly Phe 
                885                 890                 895     


Ser Ala Gln Thr Val Tyr Asp Gln Trp Phe Ile Thr Leu Phe Asn Ile 
            900                 905                 910         


Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly Ile Phe Asp Gln Asp 
        915                 920                 925             


Val Ser Asp Gln Asn Ser Val Asp Cys Pro Gln Leu Tyr Lys Pro Gly 
    930                 935                 940                 


Gln Leu Asn Leu Leu Phe Asn Lys Arg Lys Phe Phe Ile Cys Val Leu 
945                 950                 955                 960 


His Gly Ile Tyr Thr Ser Leu Val Leu Phe Phe Ile Pro Tyr Gly Ala 
                965                 970                 975     


Phe Tyr Asn Val Ala Gly Glu Asp Gly Gln His Ile Ala Asp Tyr Gln 
            980                 985                 990         


Ser Phe Ala Val Thr Met Ala Thr  Ser Leu Val Ile Val  Val Ser Val 
        995                 1000                 1005             


Gln Ile  Ala Leu Asp Thr Ser  Tyr Trp Thr Phe Ile  Asn His Val 
    1010                 1015                 1020             


Phe Ile  Trp Gly Ser Ile Ala  Ile Tyr Phe Ser Ile  Leu Phe Thr 
    1025                 1030                 1035             


Met His  Ser Asn Gly Ile Phe  Gly Ile Phe Pro Asn  Gln Phe Pro 
    1040                 1045                 1050             


Phe Val  Gly Asn Ala Arg His  Ser Leu Thr Gln Lys  Cys Ile Trp 
    1055                 1060                 1065             


Leu Val  Ile Leu Leu Thr Thr  Val Ala Ser Val Met  Pro Val Val 
    1070                 1075                 1080             


Ala Phe  Arg Phe Leu Lys Val  Asp Leu Tyr Pro Thr  Leu Ser Asp 
    1085                 1090                 1095             


Gln Ile  Arg Arg Trp Gln Lys  Ala Gln Lys Lys Ala  Arg Pro Pro 
    1100                 1105                 1110             


Ser Ser  Arg Arg Pro Arg Thr  Arg Arg Ser Ser Ser  Arg Arg Ser 
    1115                 1120                 1125             


Gly Tyr  Ala Phe Ala His Gln  Glu Gly Tyr Gly Glu  Leu Ile Thr 
    1130                 1135                 1140             


Ser Gly  Lys Asn Met Arg Ala  Lys Asn Pro Pro Pro  Thr Ser Gly 
    1145                 1150                 1155             


Leu Glu  Lys Thr His Tyr Asn  Ser Thr Ser Trp Ile  Glu Asn Leu 
    1160                 1165                 1170             


Cys Lys  Lys Thr Thr Asp Thr  Val Ser Ser Phe Ser  Gln Asp Lys 
    1175                 1180                 1185             


Thr Val  Lys Leu 
    1190         


<210>  608
<211>  2909
<212>  DNA
<213>  Homo Sapiens

<400>  608
gcactgagcc ggctcaggca gagacgcggc accatggcta gcaagaaagt ctgcattgta       60

ggctccggga actggggctc agccatcgcc aagatcgtgg gtggcaatgc agcccagctg      120

gcacagtttg acccacgggt gaccatgtgg gtatttgagg aagacattgg aggcaaaaag      180

ctgactgaga tcatcaacac gcagcatgag aatgtcaaat acctgccagg gcacaagttg      240

cccccaaatg tggtggctgt cccagatgtg gtccaggctg cagaggatgc tgacatcctg      300

atctttgtgg tgccccatca gttcatcggc aagatctgtg accagctcaa gggccatctg      360

aaggcaaacg ccactggcat atctcttatt aagggggtag acgagggccc caatgggctg      420

aagctcatct cggaagtgat tggggagcgc ctcggcatcc ccatgagtgt gctgatgggg      480

gccaacattg ccagcgaggt ggctgatgag aagttctgtg agacaaccat tggctgcaag      540

gacccggccc agggacaact cctgaaagag ctgatgcaga caccaaactt ccgtatcaca      600

gtggtgcaag aggtggacac agtagagatc tgtggagcct taaagaatgt agtggccgtg      660

ggggctggct tctgtgatgg cctgggcttt ggcgacaaca ccaaggcggc agtgatccgg      720

ctgggactca tggagatgat agccttcgcc aagctcttct gcagtggccc tgtgtcctct      780

gccaccttct tggagagctg tggtgttgct gacctgatca ctacctgcta tggagggcgg      840

aaccggaaag tggctgaggc ctttgcgcgt acaggaaagt ccattgagca gctggagaaa      900

gagttgctga atgggcagaa actgcagggg cccgagacag cccgggagct atacagcatc      960

ctccagcaca agggcctggt agacaagttt cccttgttca tggctgtgta caaggtgtgc     1020

tacgagggcc agccagtggg tgaattcatc cactgcctgc agaatcatcc agaacatatg     1080

tgagtggggc cagggcccag gccaggccgc ttttttaccc cagcggagac cagcagaagc     1140

ctggggtacc tagtcaccag gatctccagg actcccaggg agcagagtct tctcatcttt     1200

tcactggagg acaggaggct atggggccca gctacgcacc tggagatcct gaactgtcaa     1260

gccactggca gcctcatgcc accacatttg ccagaaatgc agttgccctg tccctctcca     1320

gatgtggggc tttctccata tcctctggga ggggtggaat caagccccag tgctgcctgc     1380

ttggtggcgg gggtgatgta tgtggagaag ggttggggga gaggccggta gggcaggggc     1440

tgctagtggc tgtctcacat acaccagtaa tcctgttaaa gggctgaaga agtatcttag     1500

ccacaggagc gatgaggcaa ggattgtcag ggaggggtct gggcttctga gctgatgcag     1560

gccccaagga cccctttgct gacctctgcc aggacccaca cagcttcgat ggatctcagt     1620

gtttgttaac aaaatacaaa gatctcaaac aaaccccttt tagcttctcc tagcaacatc     1680

tgtgtcctca gaaacctctg gttctccccc ttccccctcc cccaggctgc cctggcaccc     1740

aaattgctgc catgctggca tctgtagctc ggtggcttga cattctcccc agggacttcc     1800

cggttcctag ttctttgcca gctcctcccc actctgtgcg acctttccaa gccttccctc     1860

accctccccg ccagcaccct ctttggggag caggaactta atctgctgac agagctacac     1920

ctttcataac aggctcagat cactcagctc cctgtgacct ttgtattcac ccaggcttcc     1980

ttctcagtag ctctagctgg gggaggtgtc agctgggccc ctcctgtgct atctccccag     2040

aggacatccc tgactccacc cctttcttcc tcccaaactc tgcacctctt cctcagctgc     2100

tccagaccgg ccagggtaac cagctaacca tgcctggcat ctggaagcca gcaggccaga     2160

gggtggccca aaggctgatg aacggtaggg aagggtgagc agattcctat gttggtgggc     2220

accaatattc caagggcagc tctctttgct gaatgagggc cttctcgtga ggtactgaca     2280

acaccagcaa ctcgagagct gggaaactca aggaggagga agaaaatcaa aaccacccta     2340

ctccctgggg tgaggaaaga acaggagggg aggaggagga gtgtgctctg cacttgcctt     2400

gctccagcat ggggtggcag cagaggaatg tcacaggtca gcagcctagg cctccagcta     2460

taaatagtcc ggagggcccg agaggctccc gcccgtccag cagggctgtc agcttcctgt     2520

gtggcagcac ctggcacact ggctctggcc agcattatgc taaaaccctg ttactctcca     2580

atgaaccagg gaggcgggct cctctctgcg cctatccctt gagaattctg tcttaccagt     2640

gaagggtggg gctgcccaga tcaggcagca ggagtgaggg gcacagtcac cccaggcctt     2700

gctgagccca ggtctgggta ctgagtgtcc agagctgcct ccccaggagg ttaaggtggg     2760

ggcaaagggg aagcttcaag cactttgcct acttttgttc actccccagt gcactgtgac     2820

tcaggccttc ccatcaggcc tatttgtcta cccaataaag cgtgtttttt ccagaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       2909


<210>  609
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  609

Met Ala Ser Lys Lys Val Cys Ile Val Gly Ser Gly Asn Trp Gly Ser 
1               5                   10                  15      


Ala Ile Ala Lys Ile Val Gly Gly Asn Ala Ala Gln Leu Ala Gln Phe 
            20                  25                  30          


Asp Pro Arg Val Thr Met Trp Val Phe Glu Glu Asp Ile Gly Gly Lys 
        35                  40                  45              


Lys Leu Thr Glu Ile Ile Asn Thr Gln His Glu Asn Val Lys Tyr Leu 
    50                  55                  60                  


Pro Gly His Lys Leu Pro Pro Asn Val Val Ala Val Pro Asp Val Val 
65                  70                  75                  80  


Gln Ala Ala Glu Asp Ala Asp Ile Leu Ile Phe Val Val Pro His Gln 
                85                  90                  95      


Phe Ile Gly Lys Ile Cys Asp Gln Leu Lys Gly His Leu Lys Ala Asn 
            100                 105                 110         


Ala Thr Gly Ile Ser Leu Ile Lys Gly Val Asp Glu Gly Pro Asn Gly 
        115                 120                 125             


Leu Lys Leu Ile Ser Glu Val Ile Gly Glu Arg Leu Gly Ile Pro Met 
    130                 135                 140                 


Ser Val Leu Met Gly Ala Asn Ile Ala Ser Glu Val Ala Asp Glu Lys 
145                 150                 155                 160 


Phe Cys Glu Thr Thr Ile Gly Cys Lys Asp Pro Ala Gln Gly Gln Leu 
                165                 170                 175     


Leu Lys Glu Leu Met Gln Thr Pro Asn Phe Arg Ile Thr Val Val Gln 
            180                 185                 190         


Glu Val Asp Thr Val Glu Ile Cys Gly Ala Leu Lys Asn Val Val Ala 
        195                 200                 205             


Val Gly Ala Gly Phe Cys Asp Gly Leu Gly Phe Gly Asp Asn Thr Lys 
    210                 215                 220                 


Ala Ala Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe Ala Lys 
225                 230                 235                 240 


Leu Phe Cys Ser Gly Pro Val Ser Ser Ala Thr Phe Leu Glu Ser Cys 
                245                 250                 255     


Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn Arg Lys 
            260                 265                 270         


Val Ala Glu Ala Phe Ala Arg Thr Gly Lys Ser Ile Glu Gln Leu Glu 
        275                 280                 285             


Lys Glu Leu Leu Asn Gly Gln Lys Leu Gln Gly Pro Glu Thr Ala Arg 
    290                 295                 300                 


Glu Leu Tyr Ser Ile Leu Gln His Lys Gly Leu Val Asp Lys Phe Pro 
305                 310                 315                 320 


Leu Phe Met Ala Val Tyr Lys Val Cys Tyr Glu Gly Gln Pro Val Gly 
                325                 330                 335     


Glu Phe Ile His Cys Leu Gln Asn His Pro Glu His Met 
            340                 345                 


<210>  610
<211>  4772
<212>  DNA
<213>  Homo Sapiens

<400>  610
ttgggcggag atgcctttaa aaaatcatcc accgcagcgg tagaaacagt tttgtttggc       60

tttatttata cggaatggtt tttcagtgaa atgctgtctt gcttaaaaga agagatgcct      120

ccccaggagc tcacccggcg actggccaca gtgatcactc atgtcgatga aattatgcag      180

caggaagtca gacccctgat ggcggtggag ataatagaac aacttcacag acaatttgcc      240

attctttcag gaggccgagg ggaggatggc gcccccatca tcacgttccc agagttttcg      300

gggttcaaac acatcccaga tgaagacttc ctgaatgtca tgacctacct gactagcatc      360

cccagtgtgg aggctgccag cattggattc attgttgtta tcgacagacg aagagacaag      420

tggagctccg taaaggcatc cttgacacga atagctgtgg catttccagg aaacttacag      480

ctcatattca tccttcgtcc atctcgcttt atccagagga cattcactga cattggcatt      540

aaatactatc gaaatgagtt taaaacgaaa gtgccgatca tcatggtaaa ctctgtctct      600

gaccttcacg gctacatcga caaaagccaa ctgacccggg aattaggggg gactttggaa      660

tatcgccacg gtcagtgggt aaatcaccgc actgccatcg aaaactttgc cttgaccttg      720

aagaccactg cccagatgct gcagacgttt gggtcctgcc tggccacagc agagctgccc      780

agaagcatgc tatccacgga agaccttctc atgtcccaca caaggcagcg ggacaagctg      840

caggatgagc tgaaattact tggaaagcag gggaccacat tgctgtcatg catccaagaa      900

ccagcaacca aatgtcccaa cagcaaactc aatctcaacc aacttgagaa tgtaactacc      960

atggaaaggt tattagttca actggatgaa acagaaaaag cctttagtca cttttggtct     1020

gagcatcatc tgaagcttaa ccagtgccta caactacagc attttgagca cgatttttgt     1080

aaggctaagc ttgccctgga taatttgctg gaagagcaag cagagtttac aggcattgga     1140

gacagcgtga tgcacgtgga gcagattctt aaggaacaca aaaaactgga ggaaaaaagc     1200

caggagcccc tggaaaaggc ccagctgctg gcactggttg gggaccagct catccaaagc     1260

caccattatg cagcagatgc catcaggccc cggtgtgtgg agctcaggca cctctgtgac     1320

gatttcatca atggaaacaa gaaaaaatgg gacattttag gaaagtcctt agagtttcat     1380

agacagctgg acaaggtcag ccaatggtgt gaggcaggaa tctacctctt ggcttcccaa     1440

gctgtagaca agtgccagtc tcgagaaggg gttgatatcg ccttgaacga cattgcgaca     1500

ttcctgggca cagtcaagga gtacccgttg ctcagcccca aggagtttta caacgagttt     1560

gagttgctgc tcaccctcga tgcaaaggcc aaagcccaga aagttttgca gaggctggat     1620

gatgtccagg aaatatttca caagaggcaa gtgagtctga tgaaactggc agccaaacag     1680

actcgtccag tgcaacctgt ggccccacat cctgagtctt caccaaaatg ggtgtcatca     1740

aaaaccagcc agccctccac ctcggtccct ctagctcgtc ctctgagaac gtctgaggaa     1800

ccttatacgg agacagagtt gaactcccgg ggaaaggaag atgatgagac taaatttgaa     1860

gtcaagagtg aagaaatctt tgaaagccat catgaaaggg ggaaccctga gctggagcag     1920

caggccaggc tcggagacct ttccccccgc aggcgcatta tacgtgactt gcttgagact     1980

gaagagattt acataaaaga gattaaaagc ataattgatg gatatatcac tccaatggat     2040

tttatttggc taaagcatct aattccagat gttcttcaga ataacaagga ctttctcttt     2100

gggaatatta gagaacttta cgaatttcac aacaggactt ttctaaaaga gttggaaaag     2160

tgtgctgaga accctgaact tctggcacat tgctttctca agagaaaaga agatcttcag     2220

atatatttta aataccataa gaatctgccc cgagctaggg caatctggca agagtgtcaa     2280

gactgcgcct actttggggt atgccagcgc caactggatc acaatctccc tctttttaag     2340

tatctcaaag gaccaagcca gagacttata aaataccaga tgctgttgaa gggtctgctg     2400

gatttcgagt ctcctgaaga tatggagata gacccaggtg aactaggagg ctcggctaag     2460

gatgggccaa agagaaccaa agattcagca ttctcaactg aactacaaca agctttggca     2520

gtgatagagg atttgatcaa gtcctgtgag ttggctgtgg acctagcagc agtgactgaa     2580

tgtccggacg atattggaaa actaggcaag ctgttgctgc acggcccttt cagcgtctgg     2640

acaattcaca aggatcgtta taaaatgaag gatttgattc gatttaaacc cagccagagg     2700

caaatctacc tatttgaaag gggaatagtg ttctgtaaga tacgaatgga gcctggggac     2760

cagggattat ctcctcatta cagcttcaag aagaccatga agctgatgac actttcaatt     2820

cgccagcttg gaagggggag ccatagaaag tttgagattg ccagtcgaaa tggacttgag     2880

aaatacatcc tgcaggcagc ttcaaaagaa atcagagact gttggttttc agaaataagt     2940

aaattattga tggaacaaca aaataatatc aaagaccaag gaaatccaca gtttgaaatg     3000

agcacgagca aaggcagtgg agcaggatcc ggaccatgga ttaaaaatat ggaaagagct     3060

accactagca aggaagaccc ggcctccagc acaggaggga ttaaaggctg ctccagcagg     3120

gagtttagct ccatggacac ctttgaagac tgtgaaggcg cagaagacat ggaaaaggag     3180

agcagtgctc tgagtctcgc gggccttttc cagtcggacg acagtcacga aacctgttcc     3240

tccaaatctg ctttcctgga gaggggagaa agcagccagg gagaaaaaga agaacgcgat     3300

gaggaggaaa cggcgacccg cagcaccgag gaggagcgcg ctggggcgtc cacgggccgg     3360

ctggctcctg cgggggcgac ggctggtttc caggcgaggg cgctgcgccc gaggacctcc     3420

gcccaggaga gctgacctcc ctgcggacgc ccccgctcct cggctccaga gcgcccgcat     3480

tcccgggaga ggcggtgtgg gggcccgggc cctgcccagc tacgcagaaa gcagccggag     3540

cctcggcggc ggcagaaagg ggacaaccag ggcctcctcc gaggagcccg aggggtgtcc     3600

tgggtgcgcg cctagctccg cacgggggac ctcggagctg ctctaaggcg cctgcagagg     3660

cgagcagagc ccgcagccca cgccttctcg accgcgcact tcgacattcg gagccgggca     3720

attctttgct gcgtgggctt ctctgtgctc ccacggtagg atgtttagta gcacccctgg     3780

cctctaccca ctaggtgcca ggaatgcgcc accccatcct ccaccccgcc cccaaatcgt     3840

gacaatcaaa aatgcctgca gacacgcccg catttctcca gggcggggtg ggaatcggtt     3900

gagagccgct tagcccgagc cttggaggag ccggagccgc tcaaacccgg cgggggccgc     3960

agactgggag ctcccggtcc gcctcccagc atccctgcga gcgttcatgg ggtgttcgtg     4020

ttagtgccaa gattgcttcg ttgtagagag agttcgttcc aagttacttt ctgaggtatt     4080

ttatgtatcg atttattagt ttttaaatga gttttgttag tttcagttgt attttatttt     4140

tagttttatt agttgatttt catttctttg tagctttctg gttatttaat tttatagttt     4200

cagttactgg tttatagtta ctttattttc aaagttattt agttgttcat tttcagttat     4260

ttatatgtag ttgttttgtt ttaggagtta cagatgttca aattaatttg cttggaattt     4320

atttatttat ttatttattt atttttcgag acggagtctc gctctgtcgc ccaggctgga     4380

gtgcagtggt gtgatctcgg ctcactgcaa accgcctccc gggttcacgc cattctcctg     4440

cctcagcctc ctgagtagct gggactacag gcgcccgcca ccacgcccgg ctaatttttt     4500

atttggattt ttagtagaga cggggtttcc ccgtgttagc caggatggtc tcgatctcct     4560

gacctcgtga tccccctgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc     4620

gcgcccagcc ggaatttatt tttaattatc tttacaatta ttatctgagt tatttacctt     4680

catagttatt tcactttatc ttattggagt ttttgagtta tttattttta cagtaactta     4740

tttgactatt aaacactcac tggaagttca tg                                   4772


<210>  611
<211>  1114
<212>  PRT
<213>  Homo Sapiens

<400>  611

Met Leu Ser Cys Leu Lys Glu Glu Met Pro Pro Gln Glu Leu Thr Arg 
1               5                   10                  15      


Arg Leu Ala Thr Val Ile Thr His Val Asp Glu Ile Met Gln Gln Glu 
            20                  25                  30          


Val Arg Pro Leu Met Ala Val Glu Ile Ile Glu Gln Leu His Arg Gln 
        35                  40                  45              


Phe Ala Ile Leu Ser Gly Gly Arg Gly Glu Asp Gly Ala Pro Ile Ile 
    50                  55                  60                  


Thr Phe Pro Glu Phe Ser Gly Phe Lys His Ile Pro Asp Glu Asp Phe 
65                  70                  75                  80  


Leu Asn Val Met Thr Tyr Leu Thr Ser Ile Pro Ser Val Glu Ala Ala 
                85                  90                  95      


Ser Ile Gly Phe Ile Val Val Ile Asp Arg Arg Arg Asp Lys Trp Ser 
            100                 105                 110         


Ser Val Lys Ala Ser Leu Thr Arg Ile Ala Val Ala Phe Pro Gly Asn 
        115                 120                 125             


Leu Gln Leu Ile Phe Ile Leu Arg Pro Ser Arg Phe Ile Gln Arg Thr 
    130                 135                 140                 


Phe Thr Asp Ile Gly Ile Lys Tyr Tyr Arg Asn Glu Phe Lys Thr Lys 
145                 150                 155                 160 


Val Pro Ile Ile Met Val Asn Ser Val Ser Asp Leu His Gly Tyr Ile 
                165                 170                 175     


Asp Lys Ser Gln Leu Thr Arg Glu Leu Gly Gly Thr Leu Glu Tyr Arg 
            180                 185                 190         


His Gly Gln Trp Val Asn His Arg Thr Ala Ile Glu Asn Phe Ala Leu 
        195                 200                 205             


Thr Leu Lys Thr Thr Ala Gln Met Leu Gln Thr Phe Gly Ser Cys Leu 
    210                 215                 220                 


Ala Thr Ala Glu Leu Pro Arg Ser Met Leu Ser Thr Glu Asp Leu Leu 
225                 230                 235                 240 


Met Ser His Thr Arg Gln Arg Asp Lys Leu Gln Asp Glu Leu Lys Leu 
                245                 250                 255     


Leu Gly Lys Gln Gly Thr Thr Leu Leu Ser Cys Ile Gln Glu Pro Ala 
            260                 265                 270         


Thr Lys Cys Pro Asn Ser Lys Leu Asn Leu Asn Gln Leu Glu Asn Val 
        275                 280                 285             


Thr Thr Met Glu Arg Leu Leu Val Gln Leu Asp Glu Thr Glu Lys Ala 
    290                 295                 300                 


Phe Ser His Phe Trp Ser Glu His His Leu Lys Leu Asn Gln Cys Leu 
305                 310                 315                 320 


Gln Leu Gln His Phe Glu His Asp Phe Cys Lys Ala Lys Leu Ala Leu 
                325                 330                 335     


Asp Asn Leu Leu Glu Glu Gln Ala Glu Phe Thr Gly Ile Gly Asp Ser 
            340                 345                 350         


Val Met His Val Glu Gln Ile Leu Lys Glu His Lys Lys Leu Glu Glu 
        355                 360                 365             


Lys Ser Gln Glu Pro Leu Glu Lys Ala Gln Leu Leu Ala Leu Val Gly 
    370                 375                 380                 


Asp Gln Leu Ile Gln Ser His His Tyr Ala Ala Asp Ala Ile Arg Pro 
385                 390                 395                 400 


Arg Cys Val Glu Leu Arg His Leu Cys Asp Asp Phe Ile Asn Gly Asn 
                405                 410                 415     


Lys Lys Lys Trp Asp Ile Leu Gly Lys Ser Leu Glu Phe His Arg Gln 
            420                 425                 430         


Leu Asp Lys Val Ser Gln Trp Cys Glu Ala Gly Ile Tyr Leu Leu Ala 
        435                 440                 445             


Ser Gln Ala Val Asp Lys Cys Gln Ser Arg Glu Gly Val Asp Ile Ala 
    450                 455                 460                 


Leu Asn Asp Ile Ala Thr Phe Leu Gly Thr Val Lys Glu Tyr Pro Leu 
465                 470                 475                 480 


Leu Ser Pro Lys Glu Phe Tyr Asn Glu Phe Glu Leu Leu Leu Thr Leu 
                485                 490                 495     


Asp Ala Lys Ala Lys Ala Gln Lys Val Leu Gln Arg Leu Asp Asp Val 
            500                 505                 510         


Gln Glu Ile Phe His Lys Arg Gln Val Ser Leu Met Lys Leu Ala Ala 
        515                 520                 525             


Lys Gln Thr Arg Pro Val Gln Pro Val Ala Pro His Pro Glu Ser Ser 
    530                 535                 540                 


Pro Lys Trp Val Ser Ser Lys Thr Ser Gln Pro Ser Thr Ser Val Pro 
545                 550                 555                 560 


Leu Ala Arg Pro Leu Arg Thr Ser Glu Glu Pro Tyr Thr Glu Thr Glu 
                565                 570                 575     


Leu Asn Ser Arg Gly Lys Glu Asp Asp Glu Thr Lys Phe Glu Val Lys 
            580                 585                 590         


Ser Glu Glu Ile Phe Glu Ser His His Glu Arg Gly Asn Pro Glu Leu 
        595                 600                 605             


Glu Gln Gln Ala Arg Leu Gly Asp Leu Ser Pro Arg Arg Arg Ile Ile 
    610                 615                 620                 


Arg Asp Leu Leu Glu Thr Glu Glu Ile Tyr Ile Lys Glu Ile Lys Ser 
625                 630                 635                 640 


Ile Ile Asp Gly Tyr Ile Thr Pro Met Asp Phe Ile Trp Leu Lys His 
                645                 650                 655     


Leu Ile Pro Asp Val Leu Gln Asn Asn Lys Asp Phe Leu Phe Gly Asn 
            660                 665                 670         


Ile Arg Glu Leu Tyr Glu Phe His Asn Arg Thr Phe Leu Lys Glu Leu 
        675                 680                 685             


Glu Lys Cys Ala Glu Asn Pro Glu Leu Leu Ala His Cys Phe Leu Lys 
    690                 695                 700                 


Arg Lys Glu Asp Leu Gln Ile Tyr Phe Lys Tyr His Lys Asn Leu Pro 
705                 710                 715                 720 


Arg Ala Arg Ala Ile Trp Gln Glu Cys Gln Asp Cys Ala Tyr Phe Gly 
                725                 730                 735     


Val Cys Gln Arg Gln Leu Asp His Asn Leu Pro Leu Phe Lys Tyr Leu 
            740                 745                 750         


Lys Gly Pro Ser Gln Arg Leu Ile Lys Tyr Gln Met Leu Leu Lys Gly 
        755                 760                 765             


Leu Leu Asp Phe Glu Ser Pro Glu Asp Met Glu Ile Asp Pro Gly Glu 
    770                 775                 780                 


Leu Gly Gly Ser Ala Lys Asp Gly Pro Lys Arg Thr Lys Asp Ser Ala 
785                 790                 795                 800 


Phe Ser Thr Glu Leu Gln Gln Ala Leu Ala Val Ile Glu Asp Leu Ile 
                805                 810                 815     


Lys Ser Cys Glu Leu Ala Val Asp Leu Ala Ala Val Thr Glu Cys Pro 
            820                 825                 830         


Asp Asp Ile Gly Lys Leu Gly Lys Leu Leu Leu His Gly Pro Phe Ser 
        835                 840                 845             


Val Trp Thr Ile His Lys Asp Arg Tyr Lys Met Lys Asp Leu Ile Arg 
    850                 855                 860                 


Phe Lys Pro Ser Gln Arg Gln Ile Tyr Leu Phe Glu Arg Gly Ile Val 
865                 870                 875                 880 


Phe Cys Lys Ile Arg Met Glu Pro Gly Asp Gln Gly Leu Ser Pro His 
                885                 890                 895     


Tyr Ser Phe Lys Lys Thr Met Lys Leu Met Thr Leu Ser Ile Arg Gln 
            900                 905                 910         


Leu Gly Arg Gly Ser His Arg Lys Phe Glu Ile Ala Ser Arg Asn Gly 
        915                 920                 925             


Leu Glu Lys Tyr Ile Leu Gln Ala Ala Ser Lys Glu Ile Arg Asp Cys 
    930                 935                 940                 


Trp Phe Ser Glu Ile Ser Lys Leu Leu Met Glu Gln Gln Asn Asn Ile 
945                 950                 955                 960 


Lys Asp Gln Gly Asn Pro Gln Phe Glu Met Ser Thr Ser Lys Gly Ser 
                965                 970                 975     


Gly Ala Gly Ser Gly Pro Trp Ile Lys Asn Met Glu Arg Ala Thr Thr 
            980                 985                 990         


Ser Lys Glu Asp Pro Ala Ser Ser  Thr Gly Gly Ile Lys  Gly Cys Ser 
        995                 1000                 1005             


Ser Arg  Glu Phe Ser Ser Met  Asp Thr Phe Glu Asp  Cys Glu Gly 
    1010                 1015                 1020             


Ala Glu  Asp Met Glu Lys Glu  Ser Ser Ala Leu Ser  Leu Ala Gly 
    1025                 1030                 1035             


Leu Phe  Gln Ser Asp Asp Ser  His Glu Thr Cys Ser  Ser Lys Ser 
    1040                 1045                 1050             


Ala Phe  Leu Glu Arg Gly Glu  Ser Ser Gln Gly Glu  Lys Glu Glu 
    1055                 1060                 1065             


Arg Asp  Glu Glu Glu Thr Ala  Thr Arg Ser Thr Glu  Glu Glu Arg 
    1070                 1075                 1080             


Ala Gly  Ala Ser Thr Gly Arg  Leu Ala Pro Ala Gly  Ala Thr Ala 
    1085                 1090                 1095             


Gly Phe  Gln Ala Arg Ala Leu  Arg Pro Arg Thr Ser  Ala Gln Glu 
    1100                 1105                 1110             


Ser 
    


<210>  612
<211>  8306
<212>  DNA
<213>  Homo Sapiens

<400>  612
cactgctctg actgcgtcct ccccaggctg aagtgtcctc aggtttcatg tggatttgcc       60

cagtaatgga tggctccacc gaggccaggt tggggaagtt cagcctcgag gacactaggg      120

gacgaaaaac ttcaaaaaga agactctttt tattaatatt ttggcgttct ttttggagag      180

gaacttttgg gatgtagcct ttacctgttt cctgaatttg acatccaaaa agccttttgg      240

aaaacaccat tctaaattta tcctgttctg aatcatcatc gcttctgata gatgcagttg      300

cttgctgaca tcgtgatctt tgattttgta caacgctatt tgggctaact tttgggattt      360

tactttgtgc ttagaatttg aaagtagtat tcattggaaa gagactccaa gaaaatactc      420

gaagacatca aaagctggat tcgagggtat aacgtgtttt gttttgtttt ttaaattaga      480

aaaataagga attgcagtgt gattttcttt ccccctttaa cttagaggaa cgaggattat      540

acagaaattt gaaatttcaa caagaaaaac ttaagcttcc ttggattccc acgtcaaagg      600

aaagtttcaa gctttcagaa ggagttctca ctcgaagata aagaacagct cgctaaccac      660

gaaagaggaa tcgatgctca gcttttagtt gcacttccta aagttgcaga attaagacaa      720

atctttgaac caaagaagaa agaattctta gaaatgaaaa gaaaagaaag aattgccagg      780

cgcctggaag ggattgaaaa tgacactcag cccatcctct tgcagagctg cacaggattg      840

gtgactcacc gcctgctgga ggaagacacc cctcgataca tgagagccag cgaccctgcc      900

agcccccaca tcggccgatc aaatgaagag gaggaaactt ctgattcttc tctagaaaag      960

caaactcgat ccaaatactg cacagaaacc tccggtgtcc acggtgactc accctatggt     1020

tcgggtacca tggacaccca cagtctggag tccaaagccg aaagaattgc aaggtacaaa     1080

gcagaaagaa ggcgacagct ggcagagaag tatgggctga ctctggatcc cgaggccgac     1140

tccgagtatt tatcccgcta taccaagtcc aggaaggagc ctgatgctgt cgagaagcgg     1200

ggaggaaaaa gtgacaaaca ggaagagtca agcagagatg ctagttctct gtaccccggg     1260

accgagacga tggggctcag gacctgtgcc ggtgaatcca aggactatgc cctccatgtg     1320

ggtgacggct cttccgaccc ggaggtgctg ctgaacatag aaaaccaaag acgaggtcaa     1380

gagctgagtg ccacccggca ggcccatgac ctgtccccag cagccgagag ttcctcgacc     1440

ttctctttct ctgggcgaga ctcctccttc actgaagtgc cacggtcccc caagcacgcc     1500

cacagctcct ccctgcagca ggcagcctcc cggagcccct cctttggtga cccacagcta     1560

tcccctgagg cccgacccag tacagggaaa cccaaacatg agtggtttct ccagaaagat     1620

tccgaagggg acacaccttc acttatcaac tggccttcca gagttaaagt tagagaaaaa     1680

ttggtgaaag aggaaagtgc tcgaaacagc cctgaactcg cctcagagtc cgtaactcag     1740

aggagacacc agccagcgcc agtccattac gtgtcatttc agtctgagca ctcagccttt     1800

gatagggtcc ccagcaaggc agcaggctct acacgacagc caatccgtgg ctatgtccaa     1860

cccgcagata ccggtcacac cgccaagcta gtgacgccag aaaccccaga aaatgcatct     1920

gagtgtagct gggtagcatc agccacccag aatgtcccca aacctcccag cttgacggtt     1980

ctagaaggtg acggaaggga tagcccagtt ctccatgtct gcgagtcaaa agcagaagaa     2040

gaagaagggg aaggagaagg agaagaaaaa gaagaagatg tgtgcttcac tgaagctctc     2100

gagcaaagca agaaaaccct actggctttg gagggtgatg ggctagtgag aagcccagaa     2160

gatccctcta gaaatgagga ctttggtaag cctgctgtga gcacagtcac cttagagcat     2220

cagaaggaac tggaaaacgt ggcacaaccc cctcaagctc cgcaccagcc cactgagagg     2280

acaggcagga gcgagatggt tctctacatt caaagtgagc ctgtgtccca agacgccaaa     2340

ccaactggtc acaacaggga agcctcgaaa aagcgcaagg tccgtacccg ctctctgtca     2400

gatttcacag gcccccctca gctccaggcc ttgaagtata aggacccagc ttccaggaga     2460

gagctggagc tgcccagctc caagaccgaa gggccttatg gggagatcag catgctggac     2520

acaaaagtct ctgtcgccca gctccgaagt gcgttcctgg catctgccaa cgcctgcagg     2580

agacctgaac tcaaatcacg ggtggagagg tcggctgaag gacctggctt gcccaccggt     2640

gtggaacggg agagagggtc ccggaaacca agacgctatt tttctcctgg tgaaagtaga     2700

aaaacttccg agagatttag aacccaacct ataacttcag cagaacgaaa ggaatcggat     2760

aggtgcactt cacattcaga aacgccaact gtcgatgatg aagaaaaggt ggatgaacga     2820

gccaagctga gcgtcgccgc caagaggttg cttttcaggg agatggaaaa atcttttgat     2880

gaacaaaatg ttccaaagcg acgctcaaga aacacagctg tggagcagag gctacgccgt     2940

ctgcaggaca ggtccctcac ccagcccatc accactgaag aggtggtcat cgcagccact     3000

gaacctatcc ccgcttcgtg ttctgggggc acccaccctg taatggcgag acttcctagc     3060

cccactgtag ctaggagcgc tgtgcagcct gccagattgc aggcctctgc tcaccaaaag     3120

gccttagcca aggaccagac aaatgagggc aaagagcttg ctgagcaagg agaacctgat     3180

tcctccactc taagcttggc cgaaaagttg gccttgttta acaaattgtc ccagccagtc     3240

tcaaaagcga tttctacccg gaacagaata gacacgagac agaggagaat gaacgctcgc     3300

tatcaaactc agccagtcac actgggagag gtggagcagg tgcagagtgg aaagctcatt     3360

cctttctcac ctgccgtgaa cacatcagtg tctaccgtag catccacggt tgctccaatg     3420

tatgccggag atcttcgcac aaagccacct cttgaccaca atgcaagtgc cactgactat     3480

aagttttctt cttcaataga aaattcggac tctccagtta gaagcattct gaaatcgcaa     3540

gcttggcagc ctttggtaga gggtagcgag aacaagggaa tgttgagaga atatggagag     3600

acagaaagca agagagcttt gacaggtcga gacagtggga tggagaagta tgggtccttt     3660

gaggaagcag aagcatccta ccccatcctg aaccgagcca gggaaggaga cagccataag     3720

gaatctaaat atgctgttcc cagaagagga agcctggaac gggcgaaccc tcccatcacc     3780

cacctcgggg atgaaccgaa ggaattttcc atggctaaaa tgaatgcaca aggaaacttg     3840

gacttgaggg acaggctgcc ctttgaagag aaggtggagg tggagaatgt tatgaaaagg     3900

aagttttcac taagagcggc agagttcggg gagcccactt ccgagcagac ggggacagct     3960

gctgggaaaa ctattgctca aaccacagcc cccgtgtcct ggaagcccca ggattcttcg     4020

gaacagccac aggagaagct ctgcaagaat ccatgtgcga tgtttgctgc tggagagatc     4080

aaaacgccga caggggaggg ccttcttgac tcacccagca aaaccatgtc tattaaagaa     4140

agattggcac tgttgaagaa aagcggggag gaagattgga gaaacagact cagcaggagg     4200

caggagggcg gcaaggcgcc ggccagcagc ctgcacaccc aggaagcagg gcggtccctc     4260

atcaagaagc gggtcacaga aagtcgagag agccaaatga cgattgagga gaggaagcag     4320

ctcatcactg tgagagagga ggcctggaag acgagaggca gaggagcggc caacgactcg     4380

acccagttca ctgtggctgg caggatggtg aagaaaggtt tggcgtcacc tactgccata     4440

accccagtag cctcacccat ttgcggtaaa acaagaggca ccacacccgt ttccaaaccc     4500

ctggaagata tcgaagccag accagatatg cagttagaat cggacctgaa gttggacagg     4560

ctggaaacct ttctaagaag gctgaataac aaagttggcg ggatgcacga aacggtgctc     4620

actgtcaccg gcaaatctgt gaaggaggtg atgaagccag atgatgatga aacctttgcc     4680

aaattttacc gcagcgtgga ttataatatg ccaagaagtc ctgtggagat ggatgaggac     4740

ttcgatgtca ttttcgatcc ttatgcaccc aaattgacgt cttccgtggc cgagcacaag     4800

cgggcagtta ggcccaagcg ccgggttcag gcctccaaaa accccctgaa aatgctggcg     4860

gcaagagaag atctccttca ggaatacact gagcagagat taaacgttgc cttcatggag     4920

tcaaagcgga tgaaagtaga aaagatgtct tccaactcca acttctcaga agtcaccctg     4980

gcgggtttag ccagtaaaga aaacttcagc aacgtcagcc tgcggagcgt caacctgacg     5040

gaacagaact ctaacaacag cgccgtgccc tacaagaggc tgatgctgtt gcagattaaa     5100

ggaagaagac atgtgcagac caggctggtg gaacctcgag cttcggcgct caacagtggg     5160

gactgcttcc tcctgctctc tccccactgc tgcttcctgt gggtaggaga gtttgcaaac     5220

gtcatagaaa aggcgaaggc ctcagaactt gcaactttaa ttcagacaaa gagggaactt     5280

ggttgtagag ctacttatat ccaaaccatt gaagaaggaa ttaatacaca cactcatgca     5340

gccaaagact tctggaagct tctgggtggc caaaccagtt accaatctgc tggagaccca     5400

aaagaagatg aactctatga agcagccata atagaaacta actgcattta ccgtctcatg     5460

gatgacaaac ttgttcctga tgacgactac tgggggaaaa ttccgaagtg ctcccttctg     5520

caacccaaag aggtactggt gtttgatttt ggtagtgaag tttacgtatg gcatgggaaa     5580

gaagtcacat tagcacaacg aaaaatagca tttcagctgg caaagcactt atggaatgga     5640

acctttgact atgagaactg tgacatcaat cccctggatc ctggagaatg caatccgctt     5700

atccccagaa aaggacaggg gcggcccgac tgggcgatat ttgggagact tactgaacac     5760

aatgagacga ttttgttcaa agagaagttt ctggattgga cggaactgaa gagatcgaat     5820

gagaagaacc ccggggaact tgcccagcac aaggaagacc ccaggactga tgtcaaggca     5880

tacgatgtga cacggatggt gtccatgccc cagacgacag caggcaccat cctggacgga     5940

gtgaacgtcg gccgtggcta tggcctggtg gaaggacacg acaggaggca gtttgagatc     6000

accagcgttt ccgtggatgt ctggcacatc ctggaattcg actatagcag gctccccaaa     6060

caaagcatcg ggcagttcca tgagggggat gcctatgtgg tcaagtggaa gttcatggtg     6120

agcacggcag tgggaagtcg ccagaaggga gagcactcgg tgagggcagc cggcaaagag     6180

aagtgcgtct acttcttctg gcaaggccgg cactccaccg tgagtgagaa gggcacgtcg     6240

gcgctgatga cggtggagct ggacgaggaa aggggggccc aggtccaggt tctccaggga     6300

aaggagcccc cctgtttcct gcagtgtttc caggggggga tggtggtgca ctcggggagg     6360

cgggaagagg aagaagaaaa tgtgcaaagt gagtggcggc tgtactgcgt gcgtggagag     6420

gtgcccgtgg aagggaattt gctggaagtg gcctgtcact gtagcagcct gaggtccaga     6480

acttccatgg tggtgcttaa cgtcaacaag gccctcatct acctgtggca cggatgcaaa     6540

gcccaggccc acacgaagga ggtcggaagg accgctgcga acaagatcaa ggaacaatgt     6600

cccctggaag caggactgca tagtagcagc aaagtcacaa tacacgagtg tgatgaaggc     6660

tccgagccac tcggattctg ggatgcctta ggaaggagag acaggaaagc ctacgattgc     6720

atgcttcaag atcctggaag ttttaacttc gcgccccgcc tgttcatcct cagcagctcc     6780

tctggggatt ttgcagccac agagtttgtg taccctgccc gagccccctc tgtggtcagt     6840

tccatgccct tcctgcagga agatctgtac agcgcgcccc agccagcact tttccttgtt     6900

gacaatcacc acgaggtgta cctctggcaa ggctggtggc ccatcgagaa caagatcact     6960

ggttccgccc gcatccgctg ggcctccgac cggaagagtg cgatggagac tgtgctccag     7020

tactgcaaag gaaaaaatct caagaaacca gcccccaagt cttaccttat ccacgctggt     7080

ctggagcccc tgacattcac caatatgttt cccagctggg agcacagaga ggacatcgct     7140

gagatcacag agatggacac ggaagtttcc aatcagatca ccctcgtgga agacgtctta     7200

gccaagctct gtaaaaccat ttacccgctg gccgacctcc tggccaggcc actcccggag     7260

ggggtcgatc ctctgaagct tgagatctat ctcaccgacg aagacttcga gtttgcacta     7320

gacatgacga gggatgaata caacgccctg cccgcctgga agcaggtgaa cctgaagaaa     7380

gcaaaaggcc tgttctgagt ggggagacgc cagaggagcc tcacggtcac gtccaacaac     7440

accactgcac cagggaaatg gatatatatt tttggactgg tgtttttcac aaagtatttt     7500

tcaatcagag ttttcagaac ctgacattgt taaagatact gcttgtcccg gagttgtgta     7560

ttttgtaaat gttcaaggga actgtttgga aacttctttc caccattcag gaggttatca     7620

gaattaataa aagtatctgt tatgtgcact taagccgcag ctgctataga tagcactgcc     7680

ttcttgttcc agctaggcaa tgcctttttt tttttttttt gaagcagttc tctttataaa     7740

gtgttatttt gatagtttgt ggattctaaa atatatatat atttatataa acaccatata     7800

agtcaaatat gtatttaaca aagcaatatg tattcattca ctttcaagat ttgttttggt     7860

gtcaaaataa catgaaaagg tagatggagt tgcttctgtt gaattagctc tgccaccaat     7920

atgtatcttc atacacgttt ggaaatgttt cctgcagcat taggtatgac ttgttctgag     7980

tactgcttcc ggtgctaaaa tgaacaaaga atttgtactt aatggcatgg actctggaga     8040

atctatgcga atcaaccttt ctaccttaat atctccccaa aaatgtatag tgccttgttt     8100

ttatgtacag tttatataca gaaaagtttg ctctgcattt ttgatgatgg tttggaacat     8160

tatctacaat tttactctca aatagtcaaa ataaaaacat ctcaatttct aataccggtt     8220

gtaaacagta cacatgtcat tttgtgatat aggactccca aataaaagta tcagaataaa     8280

cacaacaatt aactggtaaa aaaaaa                                          8306


<210>  613
<211>  2214
<212>  PRT
<213>  Homo Sapiens

<400>  613

Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn 
1               5                   10                  15      


Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His 
            20                  25                  30          


Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro 
        35                  40                  45              


Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp 
    50                  55                  60                  


Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser 
65                  70                  75                  80  


Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His 
                85                  90                  95      


Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg 
            100                 105                 110         


Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala 
        115                 120                 125             


Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp 
    130                 135                 140                 


Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser 
145                 150                 155                 160 


Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg 
                165                 170                 175     


Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Val Gly Asp Gly 
            180                 185                 190         


Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly 
        195                 200                 205             


Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala 
    210                 215                 220                 


Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr 
225                 230                 235                 240 


Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln 
                245                 250                 255     


Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu 
            260                 265                 270         


Ala Arg Pro Ser Thr Gly Lys Pro Lys His Glu Trp Phe Leu Gln Lys 
        275                 280                 285             


Asp Ser Glu Gly Asp Thr Pro Ser Leu Ile Asn Trp Pro Ser Arg Val 
    290                 295                 300                 


Lys Val Arg Glu Lys Leu Val Lys Glu Glu Ser Ala Arg Asn Ser Pro 
305                 310                 315                 320 


Glu Leu Ala Ser Glu Ser Val Thr Gln Arg Arg His Gln Pro Ala Pro 
                325                 330                 335     


Val His Tyr Val Ser Phe Gln Ser Glu His Ser Ala Phe Asp Arg Val 
            340                 345                 350         


Pro Ser Lys Ala Ala Gly Ser Thr Arg Gln Pro Ile Arg Gly Tyr Val 
        355                 360                 365             


Gln Pro Ala Asp Thr Gly His Thr Ala Lys Leu Val Thr Pro Glu Thr 
    370                 375                 380                 


Pro Glu Asn Ala Ser Glu Cys Ser Trp Val Ala Ser Ala Thr Gln Asn 
385                 390                 395                 400 


Val Pro Lys Pro Pro Ser Leu Thr Val Leu Glu Gly Asp Gly Arg Asp 
                405                 410                 415     


Ser Pro Val Leu His Val Cys Glu Ser Lys Ala Glu Glu Glu Glu Gly 
            420                 425                 430         


Glu Gly Glu Gly Glu Glu Lys Glu Glu Asp Val Cys Phe Thr Glu Ala 
        435                 440                 445             


Leu Glu Gln Ser Lys Lys Thr Leu Leu Ala Leu Glu Gly Asp Gly Leu 
    450                 455                 460                 


Val Arg Ser Pro Glu Asp Pro Ser Arg Asn Glu Asp Phe Gly Lys Pro 
465                 470                 475                 480 


Ala Val Ser Thr Val Thr Leu Glu His Gln Lys Glu Leu Glu Asn Val 
                485                 490                 495     


Ala Gln Pro Pro Gln Ala Pro His Gln Pro Thr Glu Arg Thr Gly Arg 
            500                 505                 510         


Ser Glu Met Val Leu Tyr Ile Gln Ser Glu Pro Val Ser Gln Asp Ala 
        515                 520                 525             


Lys Pro Thr Gly His Asn Arg Glu Ala Ser Lys Lys Arg Lys Val Arg 
    530                 535                 540                 


Thr Arg Ser Leu Ser Asp Phe Thr Gly Pro Pro Gln Leu Gln Ala Leu 
545                 550                 555                 560 


Lys Tyr Lys Asp Pro Ala Ser Arg Arg Glu Leu Glu Leu Pro Ser Ser 
                565                 570                 575     


Lys Thr Glu Gly Pro Tyr Gly Glu Ile Ser Met Leu Asp Thr Lys Val 
            580                 585                 590         


Ser Val Ala Gln Leu Arg Ser Ala Phe Leu Ala Ser Ala Asn Ala Cys 
        595                 600                 605             


Arg Arg Pro Glu Leu Lys Ser Arg Val Glu Arg Ser Ala Glu Gly Pro 
    610                 615                 620                 


Gly Leu Pro Thr Gly Val Glu Arg Glu Arg Gly Ser Arg Lys Pro Arg 
625                 630                 635                 640 


Arg Tyr Phe Ser Pro Gly Glu Ser Arg Lys Thr Ser Glu Arg Phe Arg 
                645                 650                 655     


Thr Gln Pro Ile Thr Ser Ala Glu Arg Lys Glu Ser Asp Arg Cys Thr 
            660                 665                 670         


Ser His Ser Glu Thr Pro Thr Val Asp Asp Glu Glu Lys Val Asp Glu 
        675                 680                 685             


Arg Ala Lys Leu Ser Val Ala Ala Lys Arg Leu Leu Phe Arg Glu Met 
    690                 695                 700                 


Glu Lys Ser Phe Asp Glu Gln Asn Val Pro Lys Arg Arg Ser Arg Asn 
705                 710                 715                 720 


Thr Ala Val Glu Gln Arg Leu Arg Arg Leu Gln Asp Arg Ser Leu Thr 
                725                 730                 735     


Gln Pro Ile Thr Thr Glu Glu Val Val Ile Ala Ala Thr Glu Pro Ile 
            740                 745                 750         


Pro Ala Ser Cys Ser Gly Gly Thr His Pro Val Met Ala Arg Leu Pro 
        755                 760                 765             


Ser Pro Thr Val Ala Arg Ser Ala Val Gln Pro Ala Arg Leu Gln Ala 
    770                 775                 780                 


Ser Ala His Gln Lys Ala Leu Ala Lys Asp Gln Thr Asn Glu Gly Lys 
785                 790                 795                 800 


Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser Ser Thr Leu Ser Leu Ala 
                805                 810                 815     


Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser Gln Pro Val Ser Lys Ala 
            820                 825                 830         


Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg Gln Arg Arg Met Asn Ala 
        835                 840                 845             


Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly Glu Val Glu Gln Val Gln 
    850                 855                 860                 


Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala Val Asn Thr Ser Val Ser 
865                 870                 875                 880 


Thr Val Ala Ser Thr Val Ala Pro Met Tyr Ala Gly Asp Leu Arg Thr 
                885                 890                 895     


Lys Pro Pro Leu Asp His Asn Ala Ser Ala Thr Asp Tyr Lys Phe Ser 
            900                 905                 910         


Ser Ser Ile Glu Asn Ser Asp Ser Pro Val Arg Ser Ile Leu Lys Ser 
        915                 920                 925             


Gln Ala Trp Gln Pro Leu Val Glu Gly Ser Glu Asn Lys Gly Met Leu 
    930                 935                 940                 


Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg Ala Leu Thr Gly Arg Asp 
945                 950                 955                 960 


Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu Glu Ala Glu Ala Ser Tyr 
                965                 970                 975     


Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp Ser His Lys Glu Ser Lys 
            980                 985                 990         


Tyr Ala Val Pro Arg Arg Gly Ser  Leu Glu Arg Ala Asn  Pro Pro Ile 
        995                 1000                 1005             


Thr His  Leu Gly Asp Glu Pro  Lys Glu Phe Ser Met  Ala Lys Met 
    1010                 1015                 1020             


Asn Ala  Gln Gly Asn Leu Asp  Leu Arg Asp Arg Leu  Pro Phe Glu 
    1025                 1030                 1035             


Glu Lys  Val Glu Val Glu Asn  Val Met Lys Arg Lys  Phe Ser Leu 
    1040                 1045                 1050             


Arg Ala  Ala Glu Phe Gly Glu  Pro Thr Ser Glu Gln  Thr Gly Thr 
    1055                 1060                 1065             


Ala Ala  Gly Lys Thr Ile Ala  Gln Thr Thr Ala Pro  Val Ser Trp 
    1070                 1075                 1080             


Lys Pro  Gln Asp Ser Ser Glu  Gln Pro Gln Glu Lys  Leu Cys Lys 
    1085                 1090                 1095             


Asn Pro  Cys Ala Met Phe Ala  Ala Gly Glu Ile Lys  Thr Pro Thr 
    1100                 1105                 1110             


Gly Glu  Gly Leu Leu Asp Ser  Pro Ser Lys Thr Met  Ser Ile Lys 
    1115                 1120                 1125             


Glu Arg  Leu Ala Leu Leu Lys  Lys Ser Gly Glu Glu  Asp Trp Arg 
    1130                 1135                 1140             


Asn Arg  Leu Ser Arg Arg Gln  Glu Gly Gly Lys Ala  Pro Ala Ser 
    1145                 1150                 1155             


Ser Leu  His Thr Gln Glu Ala  Gly Arg Ser Leu Ile  Lys Lys Arg 
    1160                 1165                 1170             


Val Thr  Glu Ser Arg Glu Ser  Gln Met Thr Ile Glu  Glu Arg Lys 
    1175                 1180                 1185             


Gln Leu  Ile Thr Val Arg Glu  Glu Ala Trp Lys Thr  Arg Gly Arg 
    1190                 1195                 1200             


Gly Ala  Ala Asn Asp Ser Thr  Gln Phe Thr Val Ala  Gly Arg Met 
    1205                 1210                 1215             


Val Lys  Lys Gly Leu Ala Ser  Pro Thr Ala Ile Thr  Pro Val Ala 
    1220                 1225                 1230             


Ser Pro  Ile Cys Gly Lys Thr  Arg Gly Thr Thr Pro  Val Ser Lys 
    1235                 1240                 1245             


Pro Leu  Glu Asp Ile Glu Ala  Arg Pro Asp Met Gln  Leu Glu Ser 
    1250                 1255                 1260             


Asp Leu  Lys Leu Asp Arg Leu  Glu Thr Phe Leu Arg  Arg Leu Asn 
    1265                 1270                 1275             


Asn Lys  Val Gly Gly Met His  Glu Thr Val Leu Thr  Val Thr Gly 
    1280                 1285                 1290             


Lys Ser  Val Lys Glu Val Met  Lys Pro Asp Asp Asp  Glu Thr Phe 
    1295                 1300                 1305             


Ala Lys  Phe Tyr Arg Ser Val  Asp Tyr Asn Met Pro  Arg Ser Pro 
    1310                 1315                 1320             


Val Glu  Met Asp Glu Asp Phe  Asp Val Ile Phe Asp  Pro Tyr Ala 
    1325                 1330                 1335             


Pro Lys  Leu Thr Ser Ser Val  Ala Glu His Lys Arg  Ala Val Arg 
    1340                 1345                 1350             


Pro Lys  Arg Arg Val Gln Ala  Ser Lys Asn Pro Leu  Lys Met Leu 
    1355                 1360                 1365             


Ala Ala  Arg Glu Asp Leu Leu  Gln Glu Tyr Thr Glu  Gln Arg Leu 
    1370                 1375                 1380             


Asn Val  Ala Phe Met Glu Ser  Lys Arg Met Lys Val  Glu Lys Met 
    1385                 1390                 1395             


Ser Ser  Asn Ser Asn Phe Ser  Glu Val Thr Leu Ala  Gly Leu Ala 
    1400                 1405                 1410             


Ser Lys  Glu Asn Phe Ser Asn  Val Ser Leu Arg Ser  Val Asn Leu 
    1415                 1420                 1425             


Thr Glu  Gln Asn Ser Asn Asn  Ser Ala Val Pro Tyr  Lys Arg Leu 
    1430                 1435                 1440             


Met Leu  Leu Gln Ile Lys Gly  Arg Arg His Val Gln  Thr Arg Leu 
    1445                 1450                 1455             


Val Glu  Pro Arg Ala Ser Ala  Leu Asn Ser Gly Asp  Cys Phe Leu 
    1460                 1465                 1470             


Leu Leu  Ser Pro His Cys Cys  Phe Leu Trp Val Gly  Glu Phe Ala 
    1475                 1480                 1485             


Asn Val  Ile Glu Lys Ala Lys  Ala Ser Glu Leu Ala  Thr Leu Ile 
    1490                 1495                 1500             


Gln Thr  Lys Arg Glu Leu Gly  Cys Arg Ala Thr Tyr  Ile Gln Thr 
    1505                 1510                 1515             


Ile Glu  Glu Gly Ile Asn Thr  His Thr His Ala Ala  Lys Asp Phe 
    1520                 1525                 1530             


Trp Lys  Leu Leu Gly Gly Gln  Thr Ser Tyr Gln Ser  Ala Gly Asp 
    1535                 1540                 1545             


Pro Lys  Glu Asp Glu Leu Tyr  Glu Ala Ala Ile Ile  Glu Thr Asn 
    1550                 1555                 1560             


Cys Ile  Tyr Arg Leu Met Asp  Asp Lys Leu Val Pro  Asp Asp Asp 
    1565                 1570                 1575             


Tyr Trp  Gly Lys Ile Pro Lys  Cys Ser Leu Leu Gln  Pro Lys Glu 
    1580                 1585                 1590             


Val Leu  Val Phe Asp Phe Gly  Ser Glu Val Tyr Val  Trp His Gly 
    1595                 1600                 1605             


Lys Glu  Val Thr Leu Ala Gln  Arg Lys Ile Ala Phe  Gln Leu Ala 
    1610                 1615                 1620             


Lys His  Leu Trp Asn Gly Thr  Phe Asp Tyr Glu Asn  Cys Asp Ile 
    1625                 1630                 1635             


Asn Pro  Leu Asp Pro Gly Glu  Cys Asn Pro Leu Ile  Pro Arg Lys 
    1640                 1645                 1650             


Gly Gln  Gly Arg Pro Asp Trp  Ala Ile Phe Gly Arg  Leu Thr Glu 
    1655                 1660                 1665             


His Asn  Glu Thr Ile Leu Phe  Lys Glu Lys Phe Leu  Asp Trp Thr 
    1670                 1675                 1680             


Glu Leu  Lys Arg Ser Asn Glu  Lys Asn Pro Gly Glu  Leu Ala Gln 
    1685                 1690                 1695             


His Lys  Glu Asp Pro Arg Thr  Asp Val Lys Ala Tyr  Asp Val Thr 
    1700                 1705                 1710             


Arg Met  Val Ser Met Pro Gln  Thr Thr Ala Gly Thr  Ile Leu Asp 
    1715                 1720                 1725             


Gly Val  Asn Val Gly Arg Gly  Tyr Gly Leu Val Glu  Gly His Asp 
    1730                 1735                 1740             


Arg Arg  Gln Phe Glu Ile Thr  Ser Val Ser Val Asp  Val Trp His 
    1745                 1750                 1755             


Ile Leu  Glu Phe Asp Tyr Ser  Arg Leu Pro Lys Gln  Ser Ile Gly 
    1760                 1765                 1770             


Gln Phe  His Glu Gly Asp Ala  Tyr Val Val Lys Trp  Lys Phe Met 
    1775                 1780                 1785             


Val Ser  Thr Ala Val Gly Ser  Arg Gln Lys Gly Glu  His Ser Val 
    1790                 1795                 1800             


Arg Ala  Ala Gly Lys Glu Lys  Cys Val Tyr Phe Phe  Trp Gln Gly 
    1805                 1810                 1815             


Arg His  Ser Thr Val Ser Glu  Lys Gly Thr Ser Ala  Leu Met Thr 
    1820                 1825                 1830             


Val Glu  Leu Asp Glu Glu Arg  Gly Ala Gln Val Gln  Val Leu Gln 
    1835                 1840                 1845             


Gly Lys  Glu Pro Pro Cys Phe  Leu Gln Cys Phe Gln  Gly Gly Met 
    1850                 1855                 1860             


Val Val  His Ser Gly Arg Arg  Glu Glu Glu Glu Glu  Asn Val Gln 
    1865                 1870                 1875             


Ser Glu  Trp Arg Leu Tyr Cys  Val Arg Gly Glu Val  Pro Val Glu 
    1880                 1885                 1890             


Gly Asn  Leu Leu Glu Val Ala  Cys His Cys Ser Ser  Leu Arg Ser 
    1895                 1900                 1905             


Arg Thr  Ser Met Val Val Leu  Asn Val Asn Lys Ala  Leu Ile Tyr 
    1910                 1915                 1920             


Leu Trp  His Gly Cys Lys Ala  Gln Ala His Thr Lys  Glu Val Gly 
    1925                 1930                 1935             


Arg Thr  Ala Ala Asn Lys Ile  Lys Glu Gln Cys Pro  Leu Glu Ala 
    1940                 1945                 1950             


Gly Leu  His Ser Ser Ser Lys  Val Thr Ile His Glu  Cys Asp Glu 
    1955                 1960                 1965             


Gly Ser  Glu Pro Leu Gly Phe  Trp Asp Ala Leu Gly  Arg Arg Asp 
    1970                 1975                 1980             


Arg Lys  Ala Tyr Asp Cys Met  Leu Gln Asp Pro Gly  Ser Phe Asn 
    1985                 1990                 1995             


Phe Ala  Pro Arg Leu Phe Ile  Leu Ser Ser Ser Ser  Gly Asp Phe 
    2000                 2005                 2010             


Ala Ala  Thr Glu Phe Val Tyr  Pro Ala Arg Ala Pro  Ser Val Val 
    2015                 2020                 2025             


Ser Ser  Met Pro Phe Leu Gln  Glu Asp Leu Tyr Ser  Ala Pro Gln 
    2030                 2035                 2040             


Pro Ala  Leu Phe Leu Val Asp  Asn His His Glu Val  Tyr Leu Trp 
    2045                 2050                 2055             


Gln Gly  Trp Trp Pro Ile Glu  Asn Lys Ile Thr Gly  Ser Ala Arg 
    2060                 2065                 2070             


Ile Arg  Trp Ala Ser Asp Arg  Lys Ser Ala Met Glu  Thr Val Leu 
    2075                 2080                 2085             


Gln Tyr  Cys Lys Gly Lys Asn  Leu Lys Lys Pro Ala  Pro Lys Ser 
    2090                 2095                 2100             


Tyr Leu  Ile His Ala Gly Leu  Glu Pro Leu Thr Phe  Thr Asn Met 
    2105                 2110                 2115             


Phe Pro  Ser Trp Glu His Arg  Glu Asp Ile Ala Glu  Ile Thr Glu 
    2120                 2125                 2130             


Met Asp  Thr Glu Val Ser Asn  Gln Ile Thr Leu Val  Glu Asp Val 
    2135                 2140                 2145             


Leu Ala  Lys Leu Cys Lys Thr  Ile Tyr Pro Leu Ala  Asp Leu Leu 
    2150                 2155                 2160             


Ala Arg  Pro Leu Pro Glu Gly  Val Asp Pro Leu Lys  Leu Glu Ile 
    2165                 2170                 2175             


Tyr Leu  Thr Asp Glu Asp Phe  Glu Phe Ala Leu Asp  Met Thr Arg 
    2180                 2185                 2190             


Asp Glu  Tyr Asn Ala Leu Pro  Ala Trp Lys Gln Val  Asn Leu Lys 
    2195                 2200                 2205             


Lys Ala  Lys Gly Leu Phe 
    2210                 


<210>  614
<211>  1796
<212>  DNA
<213>  Homo Sapiens

<400>  614
ccttttcccc tgcctgccct tcgggcacct caggaaggca ccttcctctg tcagaatggc       60

caccatggta ccatccgtgt tgtggcccag ggcctgctgg actctgctgg tctgctgtct      120

gctgacccca ggtgtccagg ggcaggagtt ccttttgcgg gtggagcccc agaaccctgt      180

gctctctgct ggagggtccc tgtttgtgaa ctgcagtact gattgtccca gctctgagaa      240

aatcgccttg gagacgtccc tatcaaagga gctggtggcc agtggcatgg gctgggcagc      300

cttcaatctc agcaacgtga ctggcaacag tcggatcctc tgctcagtgt actgcaatgg      360

ctctcagata acaggctcct ctaacatcac cgtgtacagg ctcccggagc gtgtggagct      420

ggcacccctg cctccttggc agccggtggg ccagaacttc accctgcgct gccaagtgga      480

ggatgggtcg ccccggacca gcctcacggt ggtgctgctt cgctgggagg aggagctgag      540

ccggcagccc gcagtggagg agccagcgga ggtcactgcc actgtgctgg ccagcagaga      600

cgaccacgga gcccctttct catgccgcac agaactggac atgcagcccc aggggctggg      660

actgttcgtg aacacctcag ccccccgcca gctccgaacc tttgtcctgc ccgtgacccc      720

cccgcgcctc gtggcccccc ggttcttgga ggtggaaacg tcgtggccgg tggactgcac      780

cctagacggg ctttttccag cctcagaggc ccaggtctac ctggcgctgg gggaccagat      840

gctgaatgcg acagtcatga accacgggga cacgctaacg gccacagcca cagccacggc      900

gcgcgcggat caggagggtg cccgggagat cgtctgcaac gtgaccctag ggggcgagag      960

acgggaggcc cgggagaact tgacggtctt tagcttccta ggacccattg tgaacctcag     1020

cgagcccacc gcccatgagg ggtccacagt gaccgtgagt tgcatggctg gggctcgagt     1080

ccaggtcacg ctggacggag ttccggccgc ggccccgggg cagccagctc aacttcagct     1140

aaatgctacc gagagtgacg acggacgcag cttcttctgc agtgccactc tcgaggtgga     1200

cggcgagttc ttgcacagga acagtagcgt ccagctgcga gtcctgtatg gtcccaaaat     1260

tgaccgagcc acatgccccc agcacttgaa atggaaagat aaaacgagac acgtcctgca     1320

gtgccaagcc aggggcaacc cgtaccccga gctgcggtgt ttgaaggaag gctccagccg     1380

ggaggtgccg gtggggatcc cgttcttcgt caacgtaaca cataatggta cttatcagtg     1440

ccaagcgtcc agctcacgag gcaaatacac cctggtcgtg gtgatggaca ttgaggctgg     1500

gagctcccac tttgtccccg tcttcgtggc ggtgttactg accctgggcg tggtgactat     1560

cgtactggcc ttaatgtacg tcttcaggga gcaccaacgg agcggcagtt accatgttag     1620

ggaggagagc acctatctgc ccctcacgtc tatgcagccg acagaagcaa tgggggaaga     1680

accgtccaga gctgagtgac gctgggatcc gggatcaaag ttggcggggg cttggctgtg     1740

ccctcagatt ccgcaccaat aaagccttca aactccctaa aaaaaaaaaa aaaaaa         1796


<210>  615
<211>  547
<212>  PRT
<213>  Homo Sapiens

<400>  615

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  616
<211>  3385
<212>  DNA
<213>  Homo Sapiens

<400>  616
aagcccctgg ctgtttatac tccggagggt gtccccgtgc gtcatcggtg gagtggacca       60

aaactggtga tctgtttgcc ctgtgtgacc ttgcccagaa ccctgctgac tgagagaaca      120

catctgctgg aagtcctctg ggattcaagg tacagggaat gaagagtagt tttacagaaa      180

aaagaggaca atattgggat cacctttgac ctttccattt ggaaataata ttttctattg      240

tgttatagaa aggtgggaag ctttcatcca gaacaatgaa tttcataaag gacaatagcc      300

gagcccttat tcaaagaatg ggaatgactg ttataaagca aatcacagat gacctatttg      360

tatggaatgt tctgaatcgc gaagaagtaa acatcatttg ctgcgagaag gtggagcagg      420

atgctgctag agggatcatt cacatgattt tgaaaaaggg ttcagagtcc tgtaacctct      480

ttcttaaatc ccttaaggag tggaactatc ctctatttca ggacttgaat ggacaaagtc      540

tttttcatca gacatcagaa ggagacttgg acgatttggc tcaggattta aaggacttgt      600

accatacccc atcttttctg aacttttatc cccttggtga agatattgac attattttta      660

acttgaaaag caccttcaca gaacctgtcc tgtggaggaa ggaccaacac catcaccgcg      720

tggagcagct gaccctgaat ggcctcctgc aggctcttca gagcccctgc atcattgaag      780

gggaatctgg caaaggcaag tccactctgc tgcagcgaat tgccatgctc tggggctccg      840

gaaagtgcaa ggctctgacc aagttcaaat tcgtcttctt cctccgtctc agcagggccc      900

agggtggact ttttgaaacc ctctgtgatc aactcctgga tatacctggc acaatcagga      960

agcagacatt catggccatg ctgctgaagc tgcggcagag ggttcttttc cttcttgatg     1020

gctacaatga attcaagccc cagaactgcc cagaaatcga agccctgata aaggaaaacc     1080

accgcttcaa gaacatggtc atcgtcacca ctaccactga gtgcctgagg cacatacggc     1140

agtttggtgc cctgactgct gaggtggggg atatgacaga agacagcgcc caggctctca     1200

tccgagaagt gctgatcaag gagcttgctg aaggcttgtt gctccaaatt cagaaatcca     1260

ggtgcttgag gaatctcatg aagacccctc tctttgtggt catcacttgt gcaatccaga     1320

tgggtgaaag tgagttccac tctcacacac aaacaacgct gttccatacc ttctatgatc     1380

tgttgataca gaaaaacaaa cacaaacata aaggtgtggc tgcaagtgac ttcattcgga     1440

gcctggacca ctgtggagac ctagctctgg agggtgtgtt ctcccacaag tttgatttcg     1500

aactgcagga tgtgtccagc gtgaatgagg atgtcctgct gacaactggg ctcctctgta     1560

aatatacagc tcaaaggttc aagccaaagt ataaattctt tcacaagtca ttccaggagt     1620

acacagcagg acgaagactc agcagtttat tgacgtctca tgagccagag gaggtgacca     1680

aggggaatgg ttacttgcag aaaatggttt ccatttcgga cattacatcc acttatagca     1740

gcctgctccg gtacacctgt gggtcatctg tggaagccac cagggctgtt atgaagcacc     1800

tcgcagcagt gtatcaacac ggctgccttc tcggactttc catcgccaag aggcctctct     1860

ggagacagga atctttgcaa agtgtgaaaa acaccactga gcaagaaatt ctgaaagcca     1920

taaacatcaa ttcctttgta gagtgtggca tccatttata tcaagagagt acatccaaat     1980

cagccctgag ccaagaattt gaagctttct ttcaaggtaa aagcttatat atcaactcag     2040

ggaacatccc cgattactta tttgacttct ttgaacattt gcccaattgt gcaagtgccc     2100

tggacttcat taaactggac ttttatgggg gagctatggc ttcatgggaa aaggctgcag     2160

aagacacagg tggaatccac atggaagagg ccccagaaac ctacattccc agcagggctg     2220

tatctttgtt cttcaactgg aagcaggaat tcaggactct ggaggtcaca ctccgggatt     2280

tcagcaagtt gaataagcaa gatatcagat atctggggaa aatattcagc tctgccacaa     2340

gcctcaggct gcaaataaag agatgtgctg gtgtggctgg aagcctcagt ttggtcctca     2400

gcacctgtaa gaacatttat tctctcatgg tggaagccag tcccctcacc atagaagatg     2460

agaggcacat cacatctgta acaaacctga aaaccttgag tattcatgac ctacagaatc     2520

aacggctgcc gggtggtctg actgacagct tgggtaactt gaagaacctt acaaagctca     2580

taatggataa cataaagatg aatgaagaag atgctataaa actagctgaa ggcctgaaaa     2640

acctgaagaa gatgtgttta tttcatttga cccacttgtc tgacattgga gagggaatgg     2700

attacatagt caagtctctg tcaagtgaac cctgtgacct tgaagaaatt caattagtct     2760

cctgctgctt gtctgcaaat gcagtgaaaa tcctagctca gaatcttcac aatttggtca     2820

aactgagcat tcttgattta tcagaaaatt acctggaaaa agatggaaat gaagctcttc     2880

atgaactgat cgacaggatg aacgtgctag aacagctcac cgcactgatg ctgccctggg     2940

gctgtgacgt gcaaggcagc ctgagcagcc tgttgaaaca tttggaggag gtcccacaac     3000

tcgtcaagct tgggttgaaa aactggagac tcacagatac agagattaga attttaggtg     3060

cattttttgg aaagaaccct ctgaaaaact tccagcagtt gaatttggcg ggaaatcgtg     3120

tgagcagtga tggatggctt gccttcatgg gtgtatttga gaatcttaag caattagtgt     3180

tttttgactt tagtactaaa gaatttctac ctgatccagc attagtcaga aaacttagcc     3240

aagtgttatc caagttaact tttctgcaag aagctaggct tgttgggtgg caatttgatg     3300

atgatgatct cagtgttatt acaggtgctt ttaaactagt aactgcttaa ataaagtgta     3360

ctcgaagcca gtaaaaaaaa aaaaa                                           3385


<210>  617
<211>  1024
<212>  PRT
<213>  Homo Sapiens

<400>  617

Met Asn Phe Ile Lys Asp Asn Ser Arg Ala Leu Ile Gln Arg Met Gly 
1               5                   10                  15      


Met Thr Val Ile Lys Gln Ile Thr Asp Asp Leu Phe Val Trp Asn Val 
            20                  25                  30          


Leu Asn Arg Glu Glu Val Asn Ile Ile Cys Cys Glu Lys Val Glu Gln 
        35                  40                  45              


Asp Ala Ala Arg Gly Ile Ile His Met Ile Leu Lys Lys Gly Ser Glu 
    50                  55                  60                  


Ser Cys Asn Leu Phe Leu Lys Ser Leu Lys Glu Trp Asn Tyr Pro Leu 
65                  70                  75                  80  


Phe Gln Asp Leu Asn Gly Gln Ser Leu Phe His Gln Thr Ser Glu Gly 
                85                  90                  95      


Asp Leu Asp Asp Leu Ala Gln Asp Leu Lys Asp Leu Tyr His Thr Pro 
            100                 105                 110         


Ser Phe Leu Asn Phe Tyr Pro Leu Gly Glu Asp Ile Asp Ile Ile Phe 
        115                 120                 125             


Asn Leu Lys Ser Thr Phe Thr Glu Pro Val Leu Trp Arg Lys Asp Gln 
    130                 135                 140                 


His His His Arg Val Glu Gln Leu Thr Leu Asn Gly Leu Leu Gln Ala 
145                 150                 155                 160 


Leu Gln Ser Pro Cys Ile Ile Glu Gly Glu Ser Gly Lys Gly Lys Ser 
                165                 170                 175     


Thr Leu Leu Gln Arg Ile Ala Met Leu Trp Gly Ser Gly Lys Cys Lys 
            180                 185                 190         


Ala Leu Thr Lys Phe Lys Phe Val Phe Phe Leu Arg Leu Ser Arg Ala 
        195                 200                 205             


Gln Gly Gly Leu Phe Glu Thr Leu Cys Asp Gln Leu Leu Asp Ile Pro 
    210                 215                 220                 


Gly Thr Ile Arg Lys Gln Thr Phe Met Ala Met Leu Leu Lys Leu Arg 
225                 230                 235                 240 


Gln Arg Val Leu Phe Leu Leu Asp Gly Tyr Asn Glu Phe Lys Pro Gln 
                245                 250                 255     


Asn Cys Pro Glu Ile Glu Ala Leu Ile Lys Glu Asn His Arg Phe Lys 
            260                 265                 270         


Asn Met Val Ile Val Thr Thr Thr Thr Glu Cys Leu Arg His Ile Arg 
        275                 280                 285             


Gln Phe Gly Ala Leu Thr Ala Glu Val Gly Asp Met Thr Glu Asp Ser 
    290                 295                 300                 


Ala Gln Ala Leu Ile Arg Glu Val Leu Ile Lys Glu Leu Ala Glu Gly 
305                 310                 315                 320 


Leu Leu Leu Gln Ile Gln Lys Ser Arg Cys Leu Arg Asn Leu Met Lys 
                325                 330                 335     


Thr Pro Leu Phe Val Val Ile Thr Cys Ala Ile Gln Met Gly Glu Ser 
            340                 345                 350         


Glu Phe His Ser His Thr Gln Thr Thr Leu Phe His Thr Phe Tyr Asp 
        355                 360                 365             


Leu Leu Ile Gln Lys Asn Lys His Lys His Lys Gly Val Ala Ala Ser 
    370                 375                 380                 


Asp Phe Ile Arg Ser Leu Asp His Cys Gly Asp Leu Ala Leu Glu Gly 
385                 390                 395                 400 


Val Phe Ser His Lys Phe Asp Phe Glu Leu Gln Asp Val Ser Ser Val 
                405                 410                 415     


Asn Glu Asp Val Leu Leu Thr Thr Gly Leu Leu Cys Lys Tyr Thr Ala 
            420                 425                 430         


Gln Arg Phe Lys Pro Lys Tyr Lys Phe Phe His Lys Ser Phe Gln Glu 
        435                 440                 445             


Tyr Thr Ala Gly Arg Arg Leu Ser Ser Leu Leu Thr Ser His Glu Pro 
    450                 455                 460                 


Glu Glu Val Thr Lys Gly Asn Gly Tyr Leu Gln Lys Met Val Ser Ile 
465                 470                 475                 480 


Ser Asp Ile Thr Ser Thr Tyr Ser Ser Leu Leu Arg Tyr Thr Cys Gly 
                485                 490                 495     


Ser Ser Val Glu Ala Thr Arg Ala Val Met Lys His Leu Ala Ala Val 
            500                 505                 510         


Tyr Gln His Gly Cys Leu Leu Gly Leu Ser Ile Ala Lys Arg Pro Leu 
        515                 520                 525             


Trp Arg Gln Glu Ser Leu Gln Ser Val Lys Asn Thr Thr Glu Gln Glu 
    530                 535                 540                 


Ile Leu Lys Ala Ile Asn Ile Asn Ser Phe Val Glu Cys Gly Ile His 
545                 550                 555                 560 


Leu Tyr Gln Glu Ser Thr Ser Lys Ser Ala Leu Ser Gln Glu Phe Glu 
                565                 570                 575     


Ala Phe Phe Gln Gly Lys Ser Leu Tyr Ile Asn Ser Gly Asn Ile Pro 
            580                 585                 590         


Asp Tyr Leu Phe Asp Phe Phe Glu His Leu Pro Asn Cys Ala Ser Ala 
        595                 600                 605             


Leu Asp Phe Ile Lys Leu Asp Phe Tyr Gly Gly Ala Met Ala Ser Trp 
    610                 615                 620                 


Glu Lys Ala Ala Glu Asp Thr Gly Gly Ile His Met Glu Glu Ala Pro 
625                 630                 635                 640 


Glu Thr Tyr Ile Pro Ser Arg Ala Val Ser Leu Phe Phe Asn Trp Lys 
                645                 650                 655     


Gln Glu Phe Arg Thr Leu Glu Val Thr Leu Arg Asp Phe Ser Lys Leu 
            660                 665                 670         


Asn Lys Gln Asp Ile Arg Tyr Leu Gly Lys Ile Phe Ser Ser Ala Thr 
        675                 680                 685             


Ser Leu Arg Leu Gln Ile Lys Arg Cys Ala Gly Val Ala Gly Ser Leu 
    690                 695                 700                 


Ser Leu Val Leu Ser Thr Cys Lys Asn Ile Tyr Ser Leu Met Val Glu 
705                 710                 715                 720 


Ala Ser Pro Leu Thr Ile Glu Asp Glu Arg His Ile Thr Ser Val Thr 
                725                 730                 735     


Asn Leu Lys Thr Leu Ser Ile His Asp Leu Gln Asn Gln Arg Leu Pro 
            740                 745                 750         


Gly Gly Leu Thr Asp Ser Leu Gly Asn Leu Lys Asn Leu Thr Lys Leu 
        755                 760                 765             


Ile Met Asp Asn Ile Lys Met Asn Glu Glu Asp Ala Ile Lys Leu Ala 
    770                 775                 780                 


Glu Gly Leu Lys Asn Leu Lys Lys Met Cys Leu Phe His Leu Thr His 
785                 790                 795                 800 


Leu Ser Asp Ile Gly Glu Gly Met Asp Tyr Ile Val Lys Ser Leu Ser 
                805                 810                 815     


Ser Glu Pro Cys Asp Leu Glu Glu Ile Gln Leu Val Ser Cys Cys Leu 
            820                 825                 830         


Ser Ala Asn Ala Val Lys Ile Leu Ala Gln Asn Leu His Asn Leu Val 
        835                 840                 845             


Lys Leu Ser Ile Leu Asp Leu Ser Glu Asn Tyr Leu Glu Lys Asp Gly 
    850                 855                 860                 


Asn Glu Ala Leu His Glu Leu Ile Asp Arg Met Asn Val Leu Glu Gln 
865                 870                 875                 880 


Leu Thr Ala Leu Met Leu Pro Trp Gly Cys Asp Val Gln Gly Ser Leu 
                885                 890                 895     


Ser Ser Leu Leu Lys His Leu Glu Glu Val Pro Gln Leu Val Lys Leu 
            900                 905                 910         


Gly Leu Lys Asn Trp Arg Leu Thr Asp Thr Glu Ile Arg Ile Leu Gly 
        915                 920                 925             


Ala Phe Phe Gly Lys Asn Pro Leu Lys Asn Phe Gln Gln Leu Asn Leu 
    930                 935                 940                 


Ala Gly Asn Arg Val Ser Ser Asp Gly Trp Leu Ala Phe Met Gly Val 
945                 950                 955                 960 


Phe Glu Asn Leu Lys Gln Leu Val Phe Phe Asp Phe Ser Thr Lys Glu 
                965                 970                 975     


Phe Leu Pro Asp Pro Ala Leu Val Arg Lys Leu Ser Gln Val Leu Ser 
            980                 985                 990         


Lys Leu Thr Phe Leu Gln Glu Ala  Arg Leu Val Gly Trp  Gln Phe Asp 
        995                 1000                 1005             


Asp Asp  Asp Leu Ser Val Ile  Thr Gly Ala Phe Lys  Leu Val Thr 
    1010                 1015                 1020             


Ala 
    


<210>  618
<211>  2264
<212>  DNA
<213>  Homo Sapiens

<400>  618
gtacgccatc agccggcgcc gcgccgccgg gtgttacttt gccccgccgg cggggcggtc       60

agcctcctgt caccgcctgt tccggctatg gtcccgtccg gtgttctgta agttggcaac      120

ctaggctcct gacgcgaccc tggtcctgat ggcggcggcg acggccgcgg cagccctggc      180

ggcggccgat ccccctcccg caatgccgca ggcggcaggg gccggagggc ccacaacccg      240

cagagacttc tactggctgc gctcctttct ggccggaggt attgctggat gctgtgccaa      300

aacaacagtt gctccattgg atcgagtaaa ggttttatta caagctcaca atcaccatta      360

caagcattta ggagtatttt ctgcattgcg tgctgttcct caaaaagaag gattccttgg      420

attgtataaa ggaaatggtg caatgatgat tcgaatcttt ccctatggtg caatccagtt      480

tatggcattt gagcattata aaacgttaat tactacgaag ctgggaattt caggtcatgt      540

gcacagatta atggctggat ccatggcagg tatgacagca gttatctgta cttaccctct      600

tgacatggtt agggtccgcc tagcattcca ggtgaaaggg gaacacagct atacaggaat      660

tattcatgct ttcaaaacaa tttatgcaaa ggaaggtggt ttctttggat tttacagagg      720

tctgatgcct actattttag gaatggctcc atatgcaggt gtttcatttt ttacttttgg      780

taccttgaag agtgttgggc tttcccatgc tcctaccctt cttggcagac cttcatcaga      840

caatcctaat gtcttagttt tgaaaactca tgtaaactta ctttgtggtg gtgttgctgg      900

agcaatagcg cagacaatat cctacccatt tgatgtgact cgtcggcgaa tgcaattagg      960

aactgttctg ccggaatttg aaaagtgcct taccatgcgg gatactatga agtatgtcta     1020

tggacaccat ggaattcgaa aaggactcta tcgtggttta tctcttaatt acattcgctg     1080

tattccctct caagcagtgg cttttacaac atacgaactt atgaagcagt tttttcacct     1140

caactaaaaa aaaattatgg ttggtttttc ttaatacatt ctcagaggga gaaatgaaac     1200

attactataa ttgtgggggg aacattactt gaatggggat atttaccctg tcacaagagc     1260

cactggtatt ttagtacttg attatttttt ctttagtcac aaatcagaac tgcttaccat     1320

actttttgat gccaaacatt ataccttaga acattgaaga aaatattcct aagctgatgc     1380

tggctaaacc gctttaaagt tttatttgga agtagaacta gctttaaaac ggggttcaag     1440

aggttgccat tagctttgtc atgctgttca aagtttttaa ttgttatcat ggtttttaaa     1500

agactgacag tgtttattat tattaaaata aacagggttg gttatattgc aatagaataa     1560

tgagaattga atttttaagt tctatgaaac agccagcatt gacattttat ttttgttatc     1620

tctcttctca caattatgct ccactggata ataggaaaaa cacttctttc cttcattttt     1680

taaataaaat taatgttgta tttaaaaggt agccatgtag agacacaaaa ataaatgaag     1740

aagctggaca tggtgggatg ggcatgtggt cccagctact ctggaagctg aggtgagagg     1800

atcacttgag ccctggaatt ccatgccagc ctatgcaaca tcatgaaacc ccacttaata     1860

aatgaatgaa cgactaagtc ttgctcaaat gttattatga ggtactatga gtgacttaca     1920

tgtgttttaa aatgtcagtg tgtttcccag aggcagaaat aaaaatactg aatatctttg     1980

ctcttaaaaa aaaagtaaca ctatagattt gtttttgtta gatgatttgc tctatagtag     2040

aatatttaag tagactgtga aatatttatt aatatagatg tgaatatcaa aaaatgtttc     2100

taaggtatta tgatgcatca actagttctt ccatgtaaaa taattttagt gcaatatgaa     2160

gacgtagaaa tgtaaaatat gatttgaatt gttatccttt atattaagaa aatgttttaa     2220

aatgtaagaa ttccatttat tctgttaaaa aaaaaaaaaa aaaa                      2264


<210>  619
<211>  332
<212>  PRT
<213>  Homo Sapiens

<400>  619

Met Ala Ala Ala Thr Ala Ala Ala Ala Leu Ala Ala Ala Asp Pro Pro 
1               5                   10                  15      


Pro Ala Met Pro Gln Ala Ala Gly Ala Gly Gly Pro Thr Thr Arg Arg 
            20                  25                  30          


Asp Phe Tyr Trp Leu Arg Ser Phe Leu Ala Gly Gly Ile Ala Gly Cys 
        35                  40                  45              


Cys Ala Lys Thr Thr Val Ala Pro Leu Asp Arg Val Lys Val Leu Leu 
    50                  55                  60                  


Gln Ala His Asn His His Tyr Lys His Leu Gly Val Phe Ser Ala Leu 
65                  70                  75                  80  


Arg Ala Val Pro Gln Lys Glu Gly Phe Leu Gly Leu Tyr Lys Gly Asn 
                85                  90                  95      


Gly Ala Met Met Ile Arg Ile Phe Pro Tyr Gly Ala Ile Gln Phe Met 
            100                 105                 110         


Ala Phe Glu His Tyr Lys Thr Leu Ile Thr Thr Lys Leu Gly Ile Ser 
        115                 120                 125             


Gly His Val His Arg Leu Met Ala Gly Ser Met Ala Gly Met Thr Ala 
    130                 135                 140                 


Val Ile Cys Thr Tyr Pro Leu Asp Met Val Arg Val Arg Leu Ala Phe 
145                 150                 155                 160 


Gln Val Lys Gly Glu His Ser Tyr Thr Gly Ile Ile His Ala Phe Lys 
                165                 170                 175     


Thr Ile Tyr Ala Lys Glu Gly Gly Phe Phe Gly Phe Tyr Arg Gly Leu 
            180                 185                 190         


Met Pro Thr Ile Leu Gly Met Ala Pro Tyr Ala Gly Val Ser Phe Phe 
        195                 200                 205             


Thr Phe Gly Thr Leu Lys Ser Val Gly Leu Ser His Ala Pro Thr Leu 
    210                 215                 220                 


Leu Gly Arg Pro Ser Ser Asp Asn Pro Asn Val Leu Val Leu Lys Thr 
225                 230                 235                 240 


His Val Asn Leu Leu Cys Gly Gly Val Ala Gly Ala Ile Ala Gln Thr 
                245                 250                 255     


Ile Ser Tyr Pro Phe Asp Val Thr Arg Arg Arg Met Gln Leu Gly Thr 
            260                 265                 270         


Val Leu Pro Glu Phe Glu Lys Cys Leu Thr Met Arg Asp Thr Met Lys 
        275                 280                 285             


Tyr Val Tyr Gly His His Gly Ile Arg Lys Gly Leu Tyr Arg Gly Leu 
    290                 295                 300                 


Ser Leu Asn Tyr Ile Arg Cys Ile Pro Ser Gln Ala Val Ala Phe Thr 
305                 310                 315                 320 


Thr Tyr Glu Leu Met Lys Gln Phe Phe His Leu Asn 
                325                 330         


<210>  620
<211>  4190
<212>  DNA
<213>  Homo Sapiens

<400>  620
atatgtagcc ttttcatttt catgaaagtg aagtgatttt tagaattctt agttgttttc       60

tttagaagaa catttctagg gaataataca agaagattta ggaatcattg aagttataaa      120

tctttggaat gagcaaactc agaatggtgc tacttgaaga ctctggatct gctgacttca      180

gaagacattt tgtcaacttg agtcccttca ccattactgt ggtcttactt ctcagtgcct      240

gttttgtcac cagttctctt ggaggaacag acaaggagct gaggctagtg gatggtgaaa      300

acaagtgtag cgggagagtg gaagtgaaag tccaggagga gtggggaacg gtgtgtaata      360

atggctggag catggaagcg gtctctgtga tttgtaacca gctgggatgt ccaactgcta      420

tcaaagcccc tggatgggct aattccagtg caggttctgg acgcatttgg atggatcatg      480

tttcttgtcg tgggaatgag tcagctcttt gggattgcaa acatgatgga tggggaaagc      540

atagtaactg tactcaccaa caagatgctg gagtgacctg ctcagatgga tccaatttgg      600

aaatgaggct gacgcgtgga gggaatatgt gttctggaag aatagagatc aaattccaag      660

gacggtgggg aacagtgtgt gatgataact tcaacataga tcatgcatct gtcatttgta      720

gacaacttga atgtggaagt gctgtcagtt tctctggttc atctaatttt ggagaaggct      780

ctggaccaat ctggtttgat gatcttatat gcaacggaaa tgagtcagct ctctggaact      840

gcaaacatca aggatgggga aagcataact gtgatcatgc tgaggatgct ggagtgattt      900

gctcaaaggg agcagatctg agcctgagac tggtagatgg agtcactgaa tgttcaggaa      960

gattagaagt gagattccaa ggagaatggg ggacaatatg tgatgacggc tgggacagtt     1020

acgatgctgc tgtggcatgc aagcaactgg gatgtccaac tgccgtcaca gccattggtc     1080

gagttaacgc cagtaaggga tttggacaca tctggcttga cagcgtttct tgccagggac     1140

atgaacctgc tatctggcaa tgtaaacacc atgaatgggg aaagcattat tgcaatcaca     1200

atgaagatgc tggcgtgaca tgttctgatg gatcagatct ggagctaaga cttagaggtg     1260

gaggcagccg ctgtgctggg acagttgagg tggagattca gagactgtta gggaaggtgt     1320

gtgacagagg ctggggactg aaagaagctg atgtggtttg caggcagctg ggatgtggat     1380

ctgcactcaa aacatcttat caagtgtact ccaaaatcca ggcaacaaac acatggctgt     1440

ttctaagtag ctgtaacgga aatgaaactt ctctttggga ctgcaagaac tggcaatggg     1500

gtggacttac ctgtgatcac tatgaagaag ccaaaattac ctgctcagcc cacagggaac     1560

ccagactggt tggaggggac attccctgtt ctggacgtgt tgaagtgaag catggtgaca     1620

cgtggggctc catctgtgat tcggacttct ctctggaagc tgccagcgtt ctatgcaggg     1680

aattacagtg tggcacagtt gtctctatcc tggggggagc tcactttgga gagggaaatg     1740

gacagatctg ggctgaagaa ttccagtgtg agggacatga gtcccatctt tcactctgcc     1800

cagtagcacc ccgcccagaa ggaacttgta gccacagcag ggatgttgga gtagtctgct     1860

caagatacac agaaattcgc ttggtgaatg gcaagacccc gtgtgagggc agagtggagc     1920

tcaaaacgct tggtgcctgg ggatccctct gtaactctca ctgggacata gaagatgccc     1980

atgttctttg ccagcagctt aaatgtggag ttgccctttc taccccagga ggagcacgtt     2040

ttggaaaagg aaatggtcag atctggaggc atatgtttca ctgcactggg actgagcagc     2100

acatgggaga ttgtcctgta actgctctag gtgcttcatt atgtccttca gagcaagtgg     2160

cctctgtaat ctgctcagga aaccagtccc aaacactgtc ctcgtgcaat tcatcgtctt     2220

tgggcccaac aaggcctacc attccagaag aaagtgctgt ggcctgcata gagagtggtc     2280

aacttcgcct ggtaaatgga ggaggtcgct gtgctgggag agtagagatc tatcatgagg     2340

gctcctgggg caccatctgt gatgacagct gggacctgag tgatgcccac gtggtttgca     2400

gacagctggg ctgtggagag gccattaatg ccactggttc tgctcatttt ggggaaggaa     2460

cagggcccat ctggctggat gagatgaaat gcaatggaaa agaatcccgc atttggcagt     2520

gccattcaca cggctggggg cagcaaaatt gcaggcacaa ggaggatgcg ggagttatct     2580

gctcagaatt catgtctctg agactgacca gtgaagccag cagagaggcc tgtgcagggc     2640

gtctggaagt tttttacaat ggagcttggg gcactgttgg caagagtagc atgtctgaaa     2700

ccactgtggg tgtggtgtgc aggcagctgg gctgtgcaga caaagggaaa atcaaccctg     2760

catctttaga caaggccatg tccattccca tgtgggtgga caatgttcag tgtccaaaag     2820

gacctgacac gctgtggcag tgcccatcat ctccatggga gaagagactg gccagcccct     2880

cggaggagac ctggatcaca tgtgacaaca agataagact tcaggaagga cccacttcct     2940

gttctggacg tgtggagatc tggcatggag gttcctgggg gacagtgtgt gatgactctt     3000

gggacttgga cgatgctcag gtggtgtgtc aacaacttgg ctgtggtcca gctttgaaag     3060

cattcaaaga agcagagttt ggtcagggga ctggaccgat atggctcaat gaagtgaagt     3120

gcaaagggaa tgagtcttcc ttgtgggatt gtcctgccag acgctggggc catagtgagt     3180

gtgggcacaa ggaagacgct gcagtgaatt gcacagatat ttcagtgcag aaaaccccac     3240

aaaaagccac aacaggtcgc tcatcccgtc agtcatcctt tattgcagtc gggatccttg     3300

gggttgttct gttggccatt ttcgtcgcat tattcttctt gactaaaaag cgaagacaga     3360

gacagcggct tgcagtttcc tcaagaggag agaacttagt ccaccaaatt caataccggg     3420

agatgaattc ttgcctgaat gcagatgatc tggacctaat gaattcctca gaaaattccc     3480

atgagtcagc tgatttcagt gctgctgaac taatttctgt gtctaaattt cttcctattt     3540

ctggaatgga aaaggaggcc attctgagcc acactgaaaa ggaaaatggg aatttataac     3600

ccagtgagtt cagcctttaa gataccttga tgaagacctg gactattgaa tggagcagaa     3660

attcacctct ctcactgact attacagttg catttttatg gagttcttct tctcctagga     3720

ttcctaagac tgctgctgaa tttataaaaa ttaagtttgt gaatgtgact acttagtggt     3780

gtatatgaga ctttcaaggg aattaaataa ataaataaga atgttattga tttgagtttg     3840

ctttaattac ttgtccttaa ttctattaat ttctaaatgg gcttcctaat tttttgtaga     3900

gtttcctaga tgtattataa tgtgttttat ttgacagtgt ttcaatttgc atatacagta     3960

ctgtatattt tttcttattt ggtttgaata attttcctat taccaaataa aaataaattt     4020

atttttactt tagtttttct aagacaggaa aagttaatga tattgaaggg tctgtaaata     4080

atatatggct aactttataa ggcatgactc acaacgattc tttaactgct ttttgttact     4140

gtaattctgt tcactagaat aaaatgcaga gccacacctg gtgagggcac                4190


<210>  621
<211>  1156
<212>  PRT
<213>  Homo Sapiens

<400>  621

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  622
<211>  4190
<212>  DNA
<213>  Homo Sapiens

<400>  622
atatgtagcc ttttcatttt catgaaagtg aagtgatttt tagaattctt agttgttttc       60

tttagaagaa catttctagg gaataataca agaagattta ggaatcattg aagttataaa      120

tctttggaat gagcaaactc agaatggtgc tacttgaaga ctctggatct gctgacttca      180

gaagacattt tgtcaacttg agtcccttca ccattactgt ggtcttactt ctcagtgcct      240

gttttgtcac cagttctctt ggaggaacag acaaggagct gaggctagtg gatggtgaaa      300

acaagtgtag cgggagagtg gaagtgaaag tccaggagga gtggggaacg gtgtgtaata      360

atggctggag catggaagcg gtctctgtga tttgtaacca gctgggatgt ccaactgcta      420

tcaaagcccc tggatgggct aattccagtg caggttctgg acgcatttgg atggatcatg      480

tttcttgtcg tgggaatgag tcagctcttt gggattgcaa acatgatgga tggggaaagc      540

atagtaactg tactcaccaa caagatgctg gagtgacctg ctcagatgga tccaatttgg      600

aaatgaggct gacgcgtgga gggaatatgt gttctggaag aatagagatc aaattccaag      660

gacggtgggg aacagtgtgt gatgataact tcaacataga tcatgcatct gtcatttgta      720

gacaacttga atgtggaagt gctgtcagtt tctctggttc atctaatttt ggagaaggct      780

ctggaccaat ctggtttgat gatcttatat gcaacggaaa tgagtcagct ctctggaact      840

gcaaacatca aggatgggga aagcataact gtgatcatgc tgaggatgct ggagtgattt      900

gctcaaaggg agcagatctg agcctgagac tggtagatgg agtcactgaa tgttcaggaa      960

gattagaagt gagattccaa ggagaatggg ggacaatatg tgatgacggc tgggacagtt     1020

acgatgctgc tgtggcatgc aagcaactgg gatgtccaac tgccgtcaca gccattggtc     1080

gagttaacgc cagtaaggga tttggacaca tctggcttga cagcgtttct tgccagggac     1140

atgaacctgc tatctggcaa tgtaaacacc atgaatgggg aaagcattat tgcaatcaca     1200

atgaagatgc tggcgtgaca tgttctgatg gatcagatct ggagctaaga cttagaggtg     1260

gaggcagccg ctgtgctggg acagttgagg tggagattca gagactgtta gggaaggtgt     1320

gtgacagagg ctggggactg aaagaagctg atgtggtttg caggcagctg ggatgtggat     1380

ctgcactcaa aacatcttat caagtgtact ccaaaatcca ggcaacaaac acatggctgt     1440

ttctaagtag ctgtaacgga aatgaaactt ctctttggga ctgcaagaac tggcaatggg     1500

gtggacttac ctgtgatcac tatgaagaag ccaaaattac ctgctcagcc cacagggaac     1560

ccagactggt tggaggggac attccctgtt ctggacgtgt tgaagtgaag catggtgaca     1620

cgtggggctc catctgtgat tcggacttct ctctggaagc tgccagcgtt ctatgcaggg     1680

aattacagtg tggcacagtt gtctctatcc tggggggagc tcactttgga gagggaaatg     1740

gacagatctg ggctgaagaa ttccagtgtg agggacatga gtcccatctt tcactctgcc     1800

cagtagcacc ccgcccagaa ggaacttgta gccacagcag ggatgttgga gtagtctgct     1860

caagatacac agaaattcgc ttggtgaatg gcaagacccc gtgtgagggc agagtggagc     1920

tcaaaacgct tggtgcctgg ggatccctct gtaactctca ctgggacata gaagatgccc     1980

atgttctttg ccagcagctt aaatgtggag ttgccctttc taccccagga ggagcacgtt     2040

ttggaaaagg aaatggtcag atctggaggc atatgtttca ctgcactggg actgagcagc     2100

acatgggaga ttgtcctgta actgctctag gtgcttcatt atgtccttca gagcaagtgg     2160

cctctgtaat ctgctcagga aaccagtccc aaacactgtc ctcgtgcaat tcatcgtctt     2220

tgggcccaac aaggcctacc attccagaag aaagtgctgt ggcctgcata gagagtggtc     2280

aacttcgcct ggtaaatgga ggaggtcgct gtgctgggag agtagagatc tatcatgagg     2340

gctcctgggg caccatctgt gatgacagct gggacctgag tgatgcccac gtggtttgca     2400

gacagctggg ctgtggagag gccattaatg ccactggttc tgctcatttt ggggaaggaa     2460

cagggcccat ctggctggat gagatgaaat gcaatggaaa agaatcccgc atttggcagt     2520

gccattcaca cggctggggg cagcaaaatt gcaggcacaa ggaggatgcg ggagttatct     2580

gctcagaatt catgtctctg agactgacca gtgaagccag cagagaggcc tgtgcagggc     2640

gtctggaagt tttttacaat ggagcttggg gcactgttgg caagagtagc atgtctgaaa     2700

ccactgtggg tgtggtgtgc aggcagctgg gctgtgcaga caaagggaaa atcaaccctg     2760

catctttaga caaggccatg tccattccca tgtgggtgga caatgttcag tgtccaaaag     2820

gacctgacac gctgtggcag tgcccatcat ctccatggga gaagagactg gccagcccct     2880

cggaggagac ctggatcaca tgtgacaaca agataagact tcaggaagga cccacttcct     2940

gttctggacg tgtggagatc tggcatggag gttcctgggg gacagtgtgt gatgactctt     3000

gggacttgga cgatgctcag gtggtgtgtc aacaacttgg ctgtggtcca gctttgaaag     3060

cattcaaaga agcagagttt ggtcagggga ctggaccgat atggctcaat gaagtgaagt     3120

gcaaagggaa tgagtcttcc ttgtgggatt gtcctgccag acgctggggc catagtgagt     3180

gtgggcacaa ggaagacgct gcagtgaatt gcacagatat ttcagtgcag aaaaccccac     3240

aaaaagccac aacaggtcgc tcatcccgtc agtcatcctt tattgcagtc gggatccttg     3300

gggttgttct gttggccatt ttcgtcgcat tattcttctt gactaaaaag cgaagacaga     3360

gacagcggct tgcagtttcc tcaagaggag agaacttagt ccaccaaatt caataccggg     3420

agatgaattc ttgcctgaat gcagatgatc tggacctaat gaattcctca gaaaattccc     3480

atgagtcagc tgatttcagt gctgctgaac taatttctgt gtctaaattt cttcctattt     3540

ctggaatgga aaaggaggcc attctgagcc acactgaaaa ggaaaatggg aatttataac     3600

ccagtgagtt cagcctttaa gataccttga tgaagacctg gactattgaa tggagcagaa     3660

attcacctct ctcactgact attacagttg catttttatg gagttcttct tctcctagga     3720

ttcctaagac tgctgctgaa tttataaaaa ttaagtttgt gaatgtgact acttagtggt     3780

gtatatgaga ctttcaaggg aattaaataa ataaataaga atgttattga tttgagtttg     3840

ctttaattac ttgtccttaa ttctattaat ttctaaatgg gcttcctaat tttttgtaga     3900

gtttcctaga tgtattataa tgtgttttat ttgacagtgt ttcaatttgc atatacagta     3960

ctgtatattt tttcttattt ggtttgaata attttcctat taccaaataa aaataaattt     4020

atttttactt tagtttttct aagacaggaa aagttaatga tattgaaggg tctgtaaata     4080

atatatggct aactttataa ggcatgactc acaacgattc tttaactgct ttttgttact     4140

gtaattctgt tcactagaat aaaatgcaga gccacacctg gtgagggcac                4190


<210>  623
<211>  1156
<212>  PRT
<213>  Homo Sapiens

<400>  623

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  624
<211>  1619
<212>  DNA
<213>  Homo Sapiens

<400>  624
ctccagctga gctaagtgta gcagcagcac cagggcaggg actgactcca gcccttggac       60

tcaggacatc gcagaccttc ccttgcgtgc gtgactcatt cgcacatcca tttctgttta      120

tgcctggggt ggggagaaaa atcccaaacc agctccattg gatatgactg tgcactggag      180

ccggttgtgc tgttctctca gctgtacaca cccatcaaat cacagtgccc ctgaggacga      240

gagaaaattg aagctgtgta aatgagtatg gaagattatg atttcctgtt caaaattgtt      300

ttaattggca acgctggtgt ggggaagacg tgcctcgtcc gaagattcac tcagggtctt      360

ttccccccag gtcaaggagc cacaattgga gttgatttta tgattaagac agtggagatt      420

aatggtgaaa aagtaaagct acagatctgg gacacagcag gtcaagagag atttcggtcc      480

attacccaga gttactaccg aagcgccaat gccttgatcc tcacctatga cattacctgt      540

gaggaatcct tccgttgcct tcctgagtgg ctgcgggaga tagaacaata tgccagcaac      600

aaggtcatca ctgtgttagt gggcaacaag attgacctgg ctgaaaggag agaggtttcc      660

cagcagcgag ctgaagaatt ctcagaagct caggacatgt attatctgga gacctcagcc      720

aaggaatctg ataatgtgga gaaactcttc cttgacttag catgccgact catcagtgaa      780

gccagacaga acacacttgt gaacaatgta tcctcaccct tacctggaga agggaaaagc      840

atcagctatt tgacttgttg taatttcaac taaaggctga ggcacggaga agaaaaggaa      900

tcagcaactg ccctgatggg ccatgagatg ctggggagat ctggcgatga ctgtggctcc      960

cgctctctga ccttctgact cctgtgggct cctgagctta caaagcatgg caggccaagg     1020

gcctcgacca caggccagca ttagcagaac atataatggt ttcacccttt tccagtctgg     1080

agttggagca aggagaaaat tgcactaggc actccatgat ctgcagagca tgttgctttt     1140

gtttttttaa aaagcaagta aaagcgcatt cctaaacaga gtccgggggg aaatgtactg     1200

tagggatccc tcctgcacat cagtgggtgc atgtgggaac tcttctttag ggcttcggtg     1260

gtaatcatct gggggccctg gttttcttgt ctaccagata aaccaaaact gggaaggcca     1320

agtacagtct ctgtggtgcg tattgacgac cccatggaga ttttgaaaag tgttatttct     1380

cttgtccaca ggcactttca agaactttgg gatgtaaaaa tgaaatgaaa cctttaccca     1440

tgaccaacag taacaatcat tgttttaata atatatacaa gctccataac tccttttggt     1500

gctaatgatt ccgctatttc acagaccaaa cgttttagta cattaatgtc cttaaatgtg     1560

ttatatagaa ataaaaaaat gggggaagtc catgaatcag caaaaaaaaa aaaaaaaaa      1619


<210>  625
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  625

Met Ser Met Glu Asp Tyr Asp Phe Leu Phe Lys Ile Val Leu Ile Gly 
1               5                   10                  15      


Asn Ala Gly Val Gly Lys Thr Cys Leu Val Arg Arg Phe Thr Gln Gly 
            20                  25                  30          


Leu Phe Pro Pro Gly Gln Gly Ala Thr Ile Gly Val Asp Phe Met Ile 
        35                  40                  45              


Lys Thr Val Glu Ile Asn Gly Glu Lys Val Lys Leu Gln Ile Trp Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Gln Ser Tyr Tyr Arg 
65                  70                  75                  80  


Ser Ala Asn Ala Leu Ile Leu Thr Tyr Asp Ile Thr Cys Glu Glu Ser 
                85                  90                  95      


Phe Arg Cys Leu Pro Glu Trp Leu Arg Glu Ile Glu Gln Tyr Ala Ser 
            100                 105                 110         


Asn Lys Val Ile Thr Val Leu Val Gly Asn Lys Ile Asp Leu Ala Glu 
        115                 120                 125             


Arg Arg Glu Val Ser Gln Gln Arg Ala Glu Glu Phe Ser Glu Ala Gln 
    130                 135                 140                 


Asp Met Tyr Tyr Leu Glu Thr Ser Ala Lys Glu Ser Asp Asn Val Glu 
145                 150                 155                 160 


Lys Leu Phe Leu Asp Leu Ala Cys Arg Leu Ile Ser Glu Ala Arg Gln 
                165                 170                 175     


Asn Thr Leu Val Asn Asn Val Ser Ser Pro Leu Pro Gly Glu Gly Lys 
            180                 185                 190         


Ser Ile Ser Tyr Leu Thr Cys Cys Asn Phe Asn 
        195                 200             


<210>  626
<211>  3088
<212>  DNA
<213>  Homo Sapiens

<400>  626
cggagagccg cgcagggcgc gggccgcgcg gggtggggca gccggagcgc aggcccccga       60

tccccggcgg gcgcccccgg gcccccgcgc gcgccccggc ctccgggaga ctggcgcatg      120

ccacggagcg cccctcgggc cgccgccgct cctgcccggg cccctgctgc tgctgctgtc      180

gcctgcgcct gctgccccaa ctcggcgccc gacttcttca tggtgtgcgg aggtcatgtt      240

cgctccttag caggcaaacg acttttctcc tcgcctcctc gccccgcatg ttcaggacca      300

aacgatctgc gctcgtccgg cgtctctgga ggagccgtgc gcccggcggc gaggacgagg      360

aggagggcgc agggggaggt ggaggaggag gcgagctgcg gggagaaggg gcgacggaca      420

gccgagcgca tggggccggt ggcggcggcc cgggcagggc tggatgctgc ctgggcaagg      480

cggtgcgagg tgccaaaggt caccaccatc cccacccgcc agccgcgggc gccggcgcgg      540

ccgggggcgc cgaggcggat ctgaaggcgc tcacgcactc ggtgctcaag aaactgaagg      600

agcggcagct ggagctgctg ctccaggccg tggagtcccg cggcgggacg cgcaccgcgt      660

gcctcctgct gcccggccgc ctggactgca ggctgggccc gggggcgccc gccggcgcgc      720

agcctgcgca gccgccctcg tcctactcgc tccccctcct gctgtgcaaa gtgttcaggt      780

ggccggatct caggcattcc tcggaagtca agaggctgtg ttgctgtgaa tcttacggga      840

agatcaaccc cgagctggtg tgctgcaacc cccatcacct tagccgactc tgcgaactag      900

agtctccccc ccctccttac tccagatacc cgatggattt tctcaaacca actgcagact      960

gtccagatgc tgtgccttcc tccgctgaaa cagggggaac gaattatctg gcccctgggg     1020

ggctttcaga ttcccaactt cttctggagc ctggggatcg gtcacactgg tgcgtggtgg     1080

catactggga ggagaagacg agagtgggga ggctctactg tgtccaggag ccctctctgg     1140

atatcttcta tgatctacct caggggaatg gcttttgcct cggacagctc aattcggaca     1200

acaagagtca gctggtgcag aaggtgcgga gcaaaatcgg ctgcggcatc cagctgacgc     1260

gggaggtgga tggtgtgtgg gtgtacaacc gcagcagtta ccccatcttc atcaagtccg     1320

ccacactgga caacccggac tccaggacgc tgttggtaca caaggtgttc cccggtttct     1380

ccatcaaggc tttcgactac gagaaggcgt acagcctgca gcggcccaat gaccacgagt     1440

ttatgcagca gccgtggacg ggctttaccg tgcagatcag ctttgtgaag ggctggggcc     1500

agtgctacac ccgccagttc atcagcagct gcccgtgctg gctagaggtc atcttcaaca     1560

gccggtagcc gcgtgcggag gggacagagc gtgagctgag caggccacac ttcaaactac     1620

tttgctgcta atattttcct cctgagtgct tgcttttcat gcaaactctt tggtcgtttt     1680

ttttttgttt gttggttggt tttcttcttc tcgtcctcgt ttgtgttctg ttttgtttcg     1740

ctctttgaga aatagcttat gaaaagaatt gttgggggtt tttttggaag aaggggcagg     1800

tatgatcggc aggacaccct gataggaaga ggggaagcag aaatccaagc accaccaaac     1860

acagtgtatg aaggggggcg gtcatcattt cacttgtcag gagtgtgtgt gagtgtgagt     1920

gtgcggctgt gtgtgcacgc gtgtgcagga gcggcagatg gggagacaac gtgctctttg     1980

ttttgtgtct cttatggatg tccccagcag agaggtttgc agtcccaagc ggtgtctctc     2040

ctgccccttg gacacgctca gtggggcaga ggcagtacct gggcaagctg gcggctgggg     2100

tcccagcagc tgccaggagc acggctctgt ccccagcctg ggaaagcccc tgcccctcct     2160

ctccctcatc aaggacacgg gcctgtccac aggcttctga gcagcgagcc tgctagtggc     2220

cgaaccagaa ccaattattt tcatccttgt cttattccct tcctgccagc ccctgccatt     2280

gtagcgtctt tcttttttgg ccatctgctc ctggatctcc ctgagatggg cttcccaagg     2340

gctgccgggg cagccccctc acagtattgc tcacccagtg ccctctcccc tcagcctctc     2400

ccctgcctgc cctggtgaca tcaggttttt cccggactta gaaaaccagc tcagcactgc     2460

ctgctcccat cctgtgtgtt aagctctgct attaggccag caagcgggga tgtccctggg     2520

agggacatgc ttagcagtcc ccttccctcc aagaaggatt tggtccgtca taacccaagg     2580

taccatccta ggctgacacc taactcttct ttcatttctt ctacaactca tacactcgta     2640

tgatacttcg acactgttct tagctcaatg agcatgttta gactttaaca taagctattt     2700

ttctaactac aaaggtttaa atgaacaaga gaagcattct cattggaaat ttagcattgt     2760

agtgctttga gagagaaagg actcctgaaa aaaaacctga gatttattaa agaaaaaaat     2820

gtattttatg ttatatataa atatattatt acttgtaaat ataaagacgt tttataagca     2880

tcattattta tgtattgtgc aatgtgtata aacaagaaaa ataaagaaaa gatgcacttt     2940

gctttaatat aaatgcaaat aacaaatgcc aaattaaaaa agataaacac aagattggtg     3000

tttttttcta tgggtgttat cacctagctg aatgtttttc taaaggagtt tatgttccat     3060

taaacgattt ttaaaatgta cacttgaa                                        3088


<210>  627
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  627

Met Phe Arg Thr Lys Arg Ser Ala Leu Val Arg Arg Leu Trp Arg Ser 
1               5                   10                  15      


Arg Ala Pro Gly Gly Glu Asp Glu Glu Glu Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Glu Leu Arg Gly Glu Gly Ala Thr Asp Ser Arg Ala His 
        35                  40                  45              


Gly Ala Gly Gly Gly Gly Pro Gly Arg Ala Gly Cys Cys Leu Gly Lys 
    50                  55                  60                  


Ala Val Arg Gly Ala Lys Gly His His His Pro His Pro Pro Ala Ala 
65                  70                  75                  80  


Gly Ala Gly Ala Ala Gly Gly Ala Glu Ala Asp Leu Lys Ala Leu Thr 
                85                  90                  95      


His Ser Val Leu Lys Lys Leu Lys Glu Arg Gln Leu Glu Leu Leu Leu 
            100                 105                 110         


Gln Ala Val Glu Ser Arg Gly Gly Thr Arg Thr Ala Cys Leu Leu Leu 
        115                 120                 125             


Pro Gly Arg Leu Asp Cys Arg Leu Gly Pro Gly Ala Pro Ala Gly Ala 
    130                 135                 140                 


Gln Pro Ala Gln Pro Pro Ser Ser Tyr Ser Leu Pro Leu Leu Leu Cys 
145                 150                 155                 160 


Lys Val Phe Arg Trp Pro Asp Leu Arg His Ser Ser Glu Val Lys Arg 
                165                 170                 175     


Leu Cys Cys Cys Glu Ser Tyr Gly Lys Ile Asn Pro Glu Leu Val Cys 
            180                 185                 190         


Cys Asn Pro His His Leu Ser Arg Leu Cys Glu Leu Glu Ser Pro Pro 
        195                 200                 205             


Pro Pro Tyr Ser Arg Tyr Pro Met Asp Phe Leu Lys Pro Thr Ala Asp 
    210                 215                 220                 


Cys Pro Asp Ala Val Pro Ser Ser Ala Glu Thr Gly Gly Thr Asn Tyr 
225                 230                 235                 240 


Leu Ala Pro Gly Gly Leu Ser Asp Ser Gln Leu Leu Leu Glu Pro Gly 
                245                 250                 255     


Asp Arg Ser His Trp Cys Val Val Ala Tyr Trp Glu Glu Lys Thr Arg 
            260                 265                 270         


Val Gly Arg Leu Tyr Cys Val Gln Glu Pro Ser Leu Asp Ile Phe Tyr 
        275                 280                 285             


Asp Leu Pro Gln Gly Asn Gly Phe Cys Leu Gly Gln Leu Asn Ser Asp 
    290                 295                 300                 


Asn Lys Ser Gln Leu Val Gln Lys Val Arg Ser Lys Ile Gly Cys Gly 
305                 310                 315                 320 


Ile Gln Leu Thr Arg Glu Val Asp Gly Val Trp Val Tyr Asn Arg Ser 
                325                 330                 335     


Ser Tyr Pro Ile Phe Ile Lys Ser Ala Thr Leu Asp Asn Pro Asp Ser 
            340                 345                 350         


Arg Thr Leu Leu Val His Lys Val Phe Pro Gly Phe Ser Ile Lys Ala 
        355                 360                 365             


Phe Asp Tyr Glu Lys Ala Tyr Ser Leu Gln Arg Pro Asn Asp His Glu 
    370                 375                 380                 


Phe Met Gln Gln Pro Trp Thr Gly Phe Thr Val Gln Ile Ser Phe Val 
385                 390                 395                 400 


Lys Gly Trp Gly Gln Cys Tyr Thr Arg Gln Phe Ile Ser Ser Cys Pro 
                405                 410                 415     


Cys Trp Leu Glu Val Ile Phe Asn Ser Arg 
            420                 425     


<210>  628
<211>  2381
<212>  DNA
<213>  Homo Sapiens

<400>  628
attcggccga aggagctacg cgggccacgc tgctggctgg cctgacctag gcgcgcgggg       60

tcgggcggcc gcgcgggcgg gctgagtgag caagacaaga cactcaagaa gagcgagctg      120

cgcctgggtc ccggccaggc ttgcacgcag aggcgggcgg cagacggtgc ccggcggaat      180

ctcctgagct ccgccgccca gctctggtgc cagcgcccag tggccgccgc ttcgaaagtg      240

actggtgcct cgccgcctcc tctcggtgcg ggaccatgaa gctgctgccg tcggtggtgc      300

tgaagctctt tctggctgca gttctctcgg cactggtgac tggcgagagc ctggagcggc      360

ttcggagagg gctagctgct ggaaccagca acccggaccc tcccactgta tccacggacc      420

agctgctacc cctaggaggc ggccgggacc ggaaagtccg tgacttgcaa gaggcagatc      480

tggacctttt gagagtcact ttatcctcca agccacaagc actggccaca ccaaacaagg      540

aggagcacgg gaaaagaaag aagaaaggca aggggctagg gaagaagagg gacccatgtc      600

ttcggaaata caaggacttc tgcatccatg gagaatgcaa atatgtgaag gagctccggg      660

ctccctcctg catctgccac ccgggttacc atggagagag gtgtcatggg ctgagcctcc      720

cagtggaaaa tcgcttatat acctatgacc acacaaccat cctggccgtg gtggctgtgg      780

tgctgtcatc tgtctgtctg ctggtcatcg tggggcttct catgtttagg taccatagga      840

gaggaggtta tgatgtggaa aatgaagaga aagtgaagtt gggcatgact aattcccact      900

gagagagact tgtgctcaag gaatcggctg gggactgcta cctctgagaa gacacaaggt      960

gatttcagac tgcagagggg aaagacttcc atctagtcac aaagactcct tcgtccccag     1020

ttgccgtcta ggattgggcc tcccataatt gctttgccaa aataccagag ccttcaagtg     1080

ccaaacagag tatgtccgat ggtatctggg taagaagaaa gcaaaagcaa gggaccttca     1140

tgcccttctg attcccctcc accaaacccc acttcccctc ataagtttgt ttaaacactt     1200

atcttctgga ttagaatgcc ggttaaattc catatgctcc aggatctttg actgaaaaaa     1260

aaaaagaaga agaagaagga gagcaagaag gaaagatttg tgaactggaa gaaagcaaca     1320

aagattgaga agccatgtac tcaagtacca ccaagggatc tgccattggg accctccagt     1380

gctggatttg atgagttaac tgtgaaatac cacaagcctg agaactgaat tttgggactt     1440

ctacccagat ggaaaaataa caactatttt tgttgttgtt gtttgtaaat gcctcttaaa     1500

ttatatattt attttattct atgtatgtta atttatttag tttttaacaa tctaacaata     1560

atatttcaag tgcctagact gttactttgg caatttcctg gccctccact cctcatcccc     1620

acaatctggc ttagtgccac ccacctttgc cacaaagcta ggatggttct gtgacccatc     1680

tgtagtaatt tattgtctgt ctacatttct gcagatcttc cgtggtcaga gtgccactgc     1740

gggagctctg tatggtcagg atgtaggggt taacttggtc agagccactc tatgagttgg     1800

acttcagtct tgcctaggcg attttgtcta ccatttgtgt tttgaaagcc caaggtgctg     1860

atgtcaaagt gtaacagata tcagtgtctc cccgtgtcct ctccctgcca agtctcagaa     1920

gaggttgggc ttccatgcct gtagctttcc tggtccctca cccccatggc cccaggccca     1980

cagcgtggga actcactttc ccttgtgtca agacatttct ctaactcctg ccattcttct     2040

ggtgctactc catgcagggg tcagtgcagc agaggacagt ctggagaagg tattagcaaa     2100

gcaaaaggct gagaaggaac agggaacatt ggagctgact gttcttggta actgattacc     2160

tgccaattgc taccgagaag gttggaggtg gggaaggctt tgtataatcc cacccacctc     2220

accaaaacga tgaagttatg ctgtcatggt cctttctgga agtttctggt gccatttctg     2280

aactgttaca acttgtattt ccaaacctgg ttcatattta tactttgcaa tccaaataaa     2340

gataaccctt attccataaa aaaaaaaaaa aaaaaaaaaa a                         2381


<210>  629
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  629

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  630
<211>  1878
<212>  DNA
<213>  Homo Sapiens

<400>  630
gccaagggaa actgccgcga ggaggcggaa ggagcagagg accggcagcc ggcgtcgagg       60

cggggcgcgg gaacgacggc ggccatggcg gcctcggggc ccgggtgtcg cagctggtgc      120

ttgtgtcccg aggtgccatc cgccaccttc ttcactgcgc tgctctcgct gctggtttcc      180

gggcctcgcc tgttcctgct gcagcagccc ctggcgccct cgggcctcac gctgaagtcc      240

gaggcccttc gcaactggca agccactatg gaaggagggg tcaggattac agcagaggag      300

actggcacac agagtgttaa gtgacaccca ctcaatccac cccgaagctg ttacacttaa      360

ttaaccctca aactgcccag tgagtttaca ggctggtaac ctacatcttt gtctacgaga      420

atcccatctc cctgctctgc ggcgctatca tcatctggcg ctttgctggc aatttcgaga      480

gaaccgtggg caccgtccgc cactgcttct tcaccgtgat cttcgccatc ttctccgcta      540

tcatcttcct gtcattcgag gctgtgtcat cactgtcaaa gctgggggaa gtggaggatg      600

ccagaggttt caccccagtg gcctttgcca tgctgggagt caccaccgtc cgttctcgga      660

tgaggcgggc cctggtgttt ggcatggttg tgccctcagt cctggttccg tggctcctgc      720

tgggtgcctc gtggctcatt ccccagacct ctttcctcag taatgtctgc gggctgtcca      780

tcgggctggc ctatggcctc acctactgct attccatcga cctctcagag cgagtggcac      840

tgaagctcga tcagaccttc cccttcagcc tgatgaggag gatatccgtg ttcaagtacg      900

tctcagggtc ttcagccgag aggagggcag cccagagccg gaaactgaac ccggtgcctg      960

gctcctaccc cacacagagc tgccaccctc acctgtcccc aagccaccct gtgtcccaga     1020

cgcagcacgc cagtggtcag aagctggcct cctggccctc ctgcaccccc gggcacatgc     1080

ccaccttgcc tccgtaccag cctgcctccg gcctgtgcta tgtgcagaac cactttggtc     1140

caaaccccac ctcctccagt gtctacccag cttctgcggg cacctccctg ggcatccagc     1200

cccccacgcc tgtgaacagc cctggcacgg tgtattctgg ggccttgggc acaccagggg     1260

ctgcaggctc caaggagtcc tccagggtcc ccatgccctg agagaatttc tagggaagtc     1320

atctcacttg gccttctgaa ggtcctccct aagagtctcc tgacaaaagt tacttattga     1380

acacctctat gtgccaggct ctgtgttggg tactttgatc aatgcccctg tttcagtctc     1440

atctgtactc acggcagccc tgtggagtac ggtgtactgg cccagcttac agatgcagaa     1500

agcgagacgt tctgccatca gataaagtca cgtggctctt tagtaacacg gacaaggctc     1560

ctcgccaagg aactcgtggc agaagagggc agcagttggc agtagctgcc gatgtctgtc     1620

cccagctcca ccattcctcc ctgtggctgt gccgtgctcg tggtttcagt gtccgtgtgt     1680

ccatgtgtct gcccttcagg agctcgcagc tggtgtgctt ggcggtccca ggcctgtgta     1740

gtgtctctcc cctgctgcgg gcgcccccac cccgattcct ctccccagaa gcggtgggat     1800

gggcccccat gaactgcagc agcatgctga ggtgtccatg ttgtctgcct ttgtataaag     1860

aaacagcctc tgacctgc                                                   1878


<210>  631
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  631

Met Leu Gly Val Thr Thr Val Arg Ser Arg Met Arg Arg Ala Leu Val 
1               5                   10                  15      


Phe Gly Met Val Val Pro Ser Val Leu Val Pro Trp Leu Leu Leu Gly 
            20                  25                  30          


Ala Ser Trp Leu Ile Pro Gln Thr Ser Phe Leu Ser Asn Val Cys Gly 
        35                  40                  45              


Leu Ser Ile Gly Leu Ala Tyr Gly Leu Thr Tyr Cys Tyr Ser Ile Asp 
    50                  55                  60                  


Leu Ser Glu Arg Val Ala Leu Lys Leu Asp Gln Thr Phe Pro Phe Ser 
65                  70                  75                  80  


Leu Met Arg Arg Ile Ser Val Phe Lys Tyr Val Ser Gly Ser Ser Ala 
                85                  90                  95      


Glu Arg Arg Ala Ala Gln Ser Arg Lys Leu Asn Pro Val Pro Gly Ser 
            100                 105                 110         


Tyr Pro Thr Gln Ser Cys His Pro His Leu Ser Pro Ser His Pro Val 
        115                 120                 125             


Ser Gln Thr Gln His Ala Ser Gly Gln Lys Leu Ala Ser Trp Pro Ser 
    130                 135                 140                 


Cys Thr Pro Gly His Met Pro Thr Leu Pro Pro Tyr Gln Pro Ala Ser 
145                 150                 155                 160 


Gly Leu Cys Tyr Val Gln Asn His Phe Gly Pro Asn Pro Thr Ser Ser 
                165                 170                 175     


Ser Val Tyr Pro Ala Ser Ala Gly Thr Ser Leu Gly Ile Gln Pro Pro 
            180                 185                 190         


Thr Pro Val Asn Ser Pro Gly Thr Val Tyr Ser Gly Ala Leu Gly Thr 
        195                 200                 205             


Pro Gly Ala Ala Gly Ser Lys Glu Ser Ser Arg Val Pro Met Pro 
    210                 215                 220             


<210>  632
<211>  5762
<212>  DNA
<213>  Homo Sapiens

<400>  632
acagaaggca gttcacctct gctcccgaca gcctgggaac ccgcaagagc cccagcattt       60

gaagtctggt cttgtgaaac cccaccctcc tctggctgtg tgattgaatg ggatgccctc      120

gaggttcacc tcacctgaga gggttttggg cagatcagca gtaaggtgtt aaattttaga      180

agcctgaaaa ctccagaaga gaaaggccaa ccaactcaaa cttgaagaca tgaaatcccc      240

aaggagaacc actttgtgcc tcatgtttat tgtgatttat tcttccaaag ctgcactgaa      300

ctggaattac gagtctacta ttcatccttt gagtcttcat gaacatgaac cagctggtga      360

agaggcactg aggcaaaaac gagccgttgc cacaaaaagt cctacggctg aagaatacac      420

tgttaatatt gagatcagtt ttgaaaatgc atccttcctg gatcctatca aagcctactt      480

gaacagcctc agttttccaa ttcatgggaa taacactgac caaattaccg acattttgag      540

cataaatgtg acaacagtct gcagacctgc tggaaatgaa atctggtgct cctgcgagac      600

aggttatggg tggcctcggg aaaggtgtct tcacaatctc atttgtcaag agcgtgacgt      660

cttcctccca gggcaccatt gcagttgcct taaagaactg cctcccaatg gacctttttg      720

cctgcttcag gaagatgtta ccctgaacat gagagtcaga ctaaatgtag gctttcaaga      780

agacctcatg aacacttcct ccgccctcta taggtcctac aagaccgact tggaaacagc      840

gttccggaag ggttacggaa ttttaccagg cttcaagggc gtgactgtga cagggttcaa      900

gtctggaagt gtggttgtga catatgaagt caagactaca ccaccatcac ttgagttaat      960

acataaagcc aatgaacaag ttgtacagag cctcaatcag acctacaaaa tggactacaa     1020

ctcctttcaa gcagttacta tcaatgaaag caatttcttt gtcacaccag aaatcatctt     1080

tgaaggggac acagtcagtc tggtgtgtga aaaggaagtt ttgtcctcca atgtgtcttg     1140

gcgctatgaa gaacagcagt tggaaatcca gaacagcagc agattctcga tttacaccgc     1200

acttttcaac aacatgactt cggtgtccaa gctcaccatc cacaacatca ctccaggtga     1260

tgcaggtgaa tatgtttgca aactgatatt agacattttt gaatatgagt gcaagaagaa     1320

aatagatgtt atgcccatcc aaattttggc aaatgaagaa atgaaggtga tgtgcgacaa     1380

caatcctgta tctttgaact gctgcagtca gggtaatgtt aattggagca aagtagaatg     1440

gaagcaggaa ggaaaaataa atattccagg aacccctgag acagacatag attctagctg     1500

cagcagatac accctcaagg ctgatggaac ccagtgccca agcgggtcgt ctggaacaac     1560

agtcatctac acttgtgagt tcatcagtgc ctatggagcc agaggcagtg caaacataaa     1620

agtgacattc atctctgtgg ccaatctaac aataaccccg gacccaattt ctgtttctga     1680

gggacaaaac ttttctataa aatgcatcag tgatgtgagt aactatgatg aggtttattg     1740

gaacacttct gctggaatta aaatatacca aagattttat accacgagga ggtatcttga     1800

tggagcagaa tcagtactga cagtcaagac ctcgaccagg gagtggaatg gaacctatca     1860

ctgcatattt agatataaga attcatacag tattgcaacc aaagacgtca ttgttcaccc     1920

gctgcctcta aagctgaaca tcatggttga tcctttggaa gctactgttt catgcagtgg     1980

ttcccatcac atcaagtgct gcatagagga ggatggagac tacaaagtta ctttccatac     2040

gggttcctca tcccttcctg ctgcaaaaga agttaacaaa aaacaagtgt gctacaaaca     2100

caatttcaat gcaagctcag tttcctggtg ttcaaaaact gttgatgtgt gttgtcactt     2160

taccaatgct gctaataatt cagtctggag cccatctatg aagctgaatc tggttcctgg     2220

ggaaaacatc acatgccagg atcccgtaat aggtgtcgga gagccgggga aagtcatcca     2280

gaagctatgc cggttctcaa acgttcccag cagccctgag agtcccattg gcgggaccat     2340

cacttacaaa tgtgtaggct cccagtggga ggagaagaga aatgactgca tctctgcccc     2400

aataaacagt ctgctccaga tggctaaggc tttgatcaag agcccctctc aggatgagat     2460

gctccctaca tacctgaagg atctttctat tagcatagac aaagcggaac atgaaatcag     2520

ctcttctcct gggagtctgg gagccattat taacatcctt gatctgctct caacagttcc     2580

aacccaagta aattcagaaa tgatgacgca cgtgctctct acggttaatg tcatccttgg     2640

caagcccgtc ttgaacacct ggaaggtttt acaacagcaa tggaccaatc agagttcaca     2700

gctactacat tcagtggaaa gattttccca agcattacag tcgggagata gccctccttt     2760

gtccttctcc caaactaatg tgcagatgag cagcatggta atcaagtcca gccacccaga     2820

aacctatcaa cagaggtttg ttttcccata ctttgacctc tggggcaatg tggtcattga     2880

caagagctat ctagaaaact tgcagtcgga ttcgtctatt gtcaccatgg ctttcccaac     2940

tctccaagcc atccttgccc aggatatcca ggaaaataac tttgcagaga gcttagtgat     3000

gacaaccact gtcagccaca atacaactat gccattcagg atttcaatga cttttaagaa     3060

caatagccct tcaggcggcg aaacgaagtg tgtcttctgg aacttcaggc ttgccaacaa     3120

cacagggggg tgggacagca gtgggtgcta tgtagaagaa ggtgatgggg acaatgtcac     3180

ctgtatctgt gaccacctaa catcattctc catcctcatg tcccctgact ccccagatcc     3240

tagttctctc ctgggaatac tcctggatat tatttcttat gttggggtgg gcttttccat     3300

cttgagcttg gcagcctgtc tagttgtgga agctgtggtg tggaaatcgg tgaccaagaa     3360

ccggacttct tatatgcgcc acacctgcat agtgaatatc gctgcctccc ttctggtcgc     3420

caacacctgg ttcattgtgg tcgctgccat ccaggacaat cgctacatac tctgcaagac     3480

agcctgtgtg gctgccacct tcttcatcca cttcttctac ctcagcgtct tcttctggat     3540

gctgacactg ggcctcatgc tgttctatcg cctggttttc attctgcatg aaacaagcag     3600

gtccactcag aaagccattg ccttctgtct tggctatggc tgcccacttg ccatctcggt     3660

catcacgctg ggagccaccc agccccggga agtctatacg aggaagaatg tctgttggct     3720

caactgggag gacaccaagg ccctgctggc tttcgccatc ccagcactga tcattgtggt     3780

ggtgaacata accatcacta ttgtggtcat caccaagatc ctgaggcctt ccattggaga     3840

caagccatgc aagcaggaga agagcagcct gtttcagatc agcaagagca ttggggtcct     3900

cacaccactc ttgggcctca cttggggttt tggtctcacc actgtgttcc cagggaccaa     3960

ccttgtgttc catatcatat ttgccatcct caatgtcttc cagggattat tcattttact     4020

ctttggatgc ctctgggatc tgaaggtaca ggaagctttg ctgaataagt tttcattgtc     4080

gagatggtct tcacagcact caaagtcaac atccctgggt tcatccacac ctgtgttttc     4140

tatgagttct ccaatatcaa ggagatttaa caatttgttt ggtaaaacag gaacgtataa     4200

tgtttccacc ccagaagcaa ccagctcatc cctggaaaac tcatccagtg cttcttcgtt     4260

gctcaactaa gaacaggata atccaaccta cgtgacctcc cggggacagt ggctgtgctt     4320

ttaaaaagag atgcttgcaa agcaatgggg aacgtgttct cggggcaggt ttccgggagc     4380

agatgccaaa aagacttttt catagagaag aggctttctt ttgtaaagac agaataaaaa     4440

taattgttat gtttctgttt gttccctccc cctccccctt gtgtgatacc acatgtgtat     4500

agtatttaag tgaaactcaa gccctcaagg cccaacttct ctgtctatat tgtaatatag     4560

aatttcgaag agacattttc actttttaca cattgggcac aaagataagc tttgattaaa     4620

gtagtaagta aaaggctacc taggaaatac ttcagtgaat tctaagaagg aaggaaggaa     4680

gaaaggaagg aaagaaggga gggaaacagg gagaaaggga aaaagaagaa aaagagaaag     4740

atgaaaatag gaacaaataa agacaaacaa cattaagggc catattgtaa gatttccatg     4800

ttaatgatct aatataatca ctcagtgcaa cattgagaat ttttttttaa tggctcaaaa     4860

atggaaactg aaagcaagtc atggggaatg aatactttgg gcagtatctt cctgatgtct     4920

tcttagctaa gaggaggaaa aaaaggctga aaaaataggg aggaaattcc ttcatcagaa     4980

cgacttcaag tggataacaa tatttataag aaatgaatgg aaggaaatat gatcctcctg     5040

agactaactt tgtatgttaa ggtttgaact aagtgaatgt atctgcagag gaagtattac     5100

aaagatatgt cattagatcc aagtgctgat taaattttta tagtttatca gaaaagcctt     5160

atattttagt ttgttccaca ttttgaaagc aaaaaatata tatttgatat acccttcaat     5220

tgccaaattt gatatgttgc actgaagaca gaccctgtca tatatttaat ggcttcaagc     5280

aggtacttct ctgtgcatta tagaatagat tttaataatc ttatagcatt gtatattatt     5340

attgctgttg tcactgttat tattattgtg gatactggcc cttggtgtgt tgcatagctc     5400

cctatgtatt ctctgtttcc atctttaagt tcccagacca atatacatta agagttttgc     5460

atggtctaaa ttgtgtttat tccaaccacg tggaaagctc ctggaaagaa attttacatt     5520

cggttgttct gtgctcctaa tgacacttga ccttgttgaa caaatggcag agcctttccc     5580

aaggatttga ttgtttgtga attatctgca tgtgtgcttt tttttggtgt gtatttcatt     5640

aaaaaatata aatatttatg aaaattgcac gcatattaga gttaaccatg tactattgat     5700

acagcaacgc tacattgcaa ataaaagtcc gatcccaaaa ggagaatgag acaaaaaaaa     5760

aa                                                                    5762


<210>  633
<211>  1346
<212>  PRT
<213>  Homo Sapiens

<400>  633

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  634
<211>  10098
<212>  DNA
<213>  Homo Sapiens

<400>  634
gcagtaacca tgtggatgtg ctgctgaagc gtttcctcaa gctcgctggg gtgggaggag       60

aggaggagga ggaggtggtg gtggaggagg aggcaggggg tggagagaga gaaagcgcac      120

gccgagagga ggtgtgggtg ttccgcttcc atcctaacgg aacgagctcc ctcttcgcgg      180

acatgggatt acccagcggc tgctaacccc tctcctcgcc ctgctccccc aaaccggcgt      240

ggctccccgg gcaccaagga gctgactaca gaggagcagg atttgcaccc ctcgctgggc      300

ttgctttggc aacagagtgc ctgacccagg tcaggatttt caagaaagac atgtctgaca      360

aaatgtctag cttcctacat attggagaca tttgttctct gtacgcggag ggatcgacaa      420

atggatttat tagcaccttg ggcctggttg atgatcgttg tgttgtacag ccagaaaccg      480

gggaccttaa caatccacct aagaaattca gagactgcct ctttaagcta tgtcccatga      540

accgctactc tgcccaaaag cagttctgga aagccgctaa gcctggggcc aacagcacca      600

cagacgcagt gctactcaac aaactgcacc acgctgcaga cttggaaaag aagcagaatg      660

agacagaaaa caggaaattg ctggggaccg taatccagta tggcaatgtg atccagctcc      720

tgcatttgaa aagtaataaa tacctaacag tgaataagag gcttcctgct ctgttggaga      780

agaatgccat gagagtcaca ttggacgagg ctggaaatga agggtcctgg ttttatattc      840

agccattcta caagctgcga tccattggag acagcgtggt cataggtgac aaggtggttc      900

tgaaccccgt caatgctggt cagcccctac atgctagcag ccatcaactg gtagataacc      960

caggctgcaa tgaggtcaat tccgtcaact gcaatacaag ctggaaaata gtccttttca     1020

tgaaatggag tgataacaaa gacgacatat taaagggggg tgacgtggtg aggctgtttc     1080

atgctgagca ggagaagttt ctcacctgtg acgaacacag gaagaagcag cacgtcttcc     1140

tgagaaccac gggccggcag tcggccacat ctgccaccag ttcaaaagcc ctgtgggagg     1200

tggaggtggt ccagcatgac ccatgtcggg gcggagcagg gtattggaac agccttttcc     1260

gtttcaagca tctggccacg gggcattact tggcagcaga ggtagaccct gactttgagg     1320

aagaatgcct ggagtttcag ccctcagtgg accctgatca ggacgcctct cgaagtaggt     1380

tgcggaatgc ccaagaaaag atggtatact ccctggtctc tgtgcctgaa ggcaatgaca     1440

tctcctccat tttcgagcta gatcccacca ctctgcgtgg aggtgacagc cttgtcccaa     1500

ggaactctta tgttcggctc agacacctat gtactaatac ctgggttcac agcacaaata     1560

ttcctattga caaggaagaa gaaaagcccg tgatgctgaa aattggcacc tctcctgtga     1620

aggaggataa ggaagcattt gccatagttc cggtttctcc tgctgaagtt cgggacctgg     1680

actttgccaa tgatgccagc aaggtgctgg gctccattgc tgggaagcta gagaagggca     1740

ccatcaccca gaatgaaagg aggtctgtaa ccaagctgct agaagatttg gtttacttcg     1800

tcactggtgg aactaattct ggtcaagatg ttctcgaagt tgtcttctcc aagcccaaca     1860

gagaacggca gaaactgatg agagaacaga atattctcaa gcagatcttc aagttgttac     1920

aagccccatt cacagactgc ggtgatggcc caatgcttcg gctggaagag ctcggggacc     1980

agcggcacgc tcctttcaga cacatctgcc ggctctgcta cagggtgctg agacactcgc     2040

agcaagacta caggaagaac caggagtata tagccaagca gtttggcttc atgcagaagc     2100

agattggcta tgatgtgttg gctgaagaca ctatcactgc cctgctccac aataatcgga     2160

aactcctgga aaaacacatt accgcggcag agattgacac atttgtcagc ctggtgcgaa     2220

agaacaggga gcccagattc ttagattacc tctccgacct ctgtgtctcc atgaacaaat     2280

caattccagt gacccaggaa ctgatatgta aagctgtgct gaaccccacc aacgctgaca     2340

tcctgattga gaccaagttg gttctttctc gttttgaatt tgaaggtgtc tcttccactg     2400

gagagaatgc tctggaggca ggagaagacg aggaagaggt gtggctgttt tggagggaca     2460

gcaacaaaga gattcgcagc aagagtgtga gggaattggc tcaggatgct aaagaagggc     2520

agaaggagga ccgagacgtt ctcagctact acagatatca gctgaacctc tttgcgagga     2580

tgtgtctgga ccgccaatac ctggccatca acgaaatctc aggccagctg gatgtcgatc     2640

tcattctccg ctgcatgtct gacgagaacc tgccctatga cctcagggcg tccttctgcc     2700

gcctcatgct tcacatgcat gtggaccgag atccccagga acaagtcacc cccgtgaaat     2760

atgcccgcct ctggtcggag attccctcgg agatcgccat tgacgactat gatagtagtg     2820

gagcttccaa agatgaaatt aaggagagat ttgctcagac catggagttt gtggaggagt     2880

atttaagaga tgtggtttgt cagaggttcc ctttctctga taaagagaag aataagctta     2940

cgtttgaggt tgtaaattta gctaggaatc tcatatactt tggtttctac aacttctctg     3000

accttctacg attaactaag atccttctgg ccatattgga ctgtgtacat gtgacaacaa     3060

tcttccccat tagcaagatg gcgaaaggag aagagaataa aggcagtaac gtgatgagat     3120

ctattcatgg cgtgggagag ctgatgaccc aggtggtgct ccggggagga ggctttttgc     3180

ccatgactcc catggctgct gcccctgaag gcaatgtgaa gcaggcagag cctgagaagg     3240

aggacatcat ggtcatggac accaagctga agatcattga gatactccag tttattttga     3300

atgtgaggtt ggattatagg atctcctgcc tcctgtgtat atttaagcga gagtttgatg     3360

aaagcaattc ccagacttca gaaacatcct ccggaaacag cagccaagaa gggccaagta     3420

atgtaccagg tgctcttgac tttgaacaca ttgaagaaca agcagaaggc atctttggag     3480

gaagtgagga gaacacccca ctggacttgg atgaccacgg cggcagaacc tttctccgtg     3540

tcctgctcca cttgacgatg catgactacc cacccctggt gtcaggggcc ctgcagctcc     3600

tcttccggca cttcagccag aggcaggagg tgctccaggc cttcaaacag gttcaactgc     3660

tggttaccag ccaagatgtg gacaactaca aacagatcaa acaagacttg gatcaactga     3720

ggtccatcgt ggaaaagtca gagctttggg tgtacaaagg gcagggcccc gatgagacta     3780

tggatggtgc atctggagaa aatgaacata agaaaacgga ggagggaaat aacaagccac     3840

aaaagcatga aagcaccagc agctacaact acagagtggt caaagagatt ttgattcggc     3900

ttagcaaact ctgtgttcaa gagagtgcct cagtgagaaa gagcaggaag cagcaacagc     3960

gtctgctccg gaacatgggc gcgcacgccg tggtgctgga gctgctgcag attccctatg     4020

agaaggccga agataccaag atgcaagaga taatgaggtt ggctcatgaa tttttgcaga     4080

atttctgcgc aggcaaccag cagaatcaag ctttgctaca taaacacata aacctgtttc     4140

tcaacccagg gatcctggag gcagtaacca tgcagcacat cttcatgaac aatttccagc     4200

tttgcagtga gatcaacgag agagttgttc agcacttcgt tcactgcata gagactcacg     4260

gtcggaatgt ccagtatata aagttcttac agacaattgt caaggcagaa gggaaattta     4320

ttaaaaaatg ccaagacatg gttatggccg agctggtcaa ttcgggagag gatgtcctcg     4380

tgttctacaa cgacagagcc tctttccaga ctctgatcca gatgatgcgg tcagaacggg     4440

atcggatgga tgagaacagc cctctcatgt accacatcca cttggtcgag ctcctggctg     4500

tgtgcacgga gggtaagaat gtctacacag agatcaagtg caactccctg ctcccgctgg     4560

atgacatcgt tcgcgtggtg acccacgagg actgcatccc tgaggttaaa attgcataca     4620

ttaacttcct gaatcactgc tatgtggata cagaggtgga aatgaaggag atttatacca     4680

gcaatcacat gtggaaattg tttgagaatt tccttgtaga catctgcagg gcctgtaaca     4740

acactagtga caggaaacat gcagactcga ttttggagaa gtatgtcacc gaaatcgtca     4800

tgagtattgt tactactttc ttcagctctc ccttctcaga ccagagtacg actttgcaga     4860

ctcgccagcc tgtctttgtg caactgctgc aaggcgtgtt cagggtttac cactgcaact     4920

ggttaatgcc aagccaaaaa gcctccgtgg agagctgtat tcgggtgctg tctgatgtag     4980

ccaagagccg ggccattgcc attcccgtgg acctggacag ccaagtcaac aacctctttc     5040

tcaagtccca cagcattgtg cagaaaacag ccatgaactg gcggctctca gcccgcaatg     5100

ccgcacgcag ggactctgtt ctggcagctt ccagagacta ccggaatatc attgagagat     5160

tgcaggacat cgtctccgcg ctggaggacc gtctcaggcc cctggtgcag gcagagttat     5220

ctgtgctcgt ggatgttctc cacagacccg agctgctttt cccagagaac acagacgcca     5280

gaaggaaatg tgaaagtggc ggtttcattt gcaagttaat aaagcataca aaacagctgc     5340

tagaagaaaa tgaagagaag ctctgcatta aggtcctaca gaccctgagg gaaatgatga     5400

ccaaagatag aggctatgga gaaaagggtg aggcgctcag gcaagttctg gtcaaccgtt     5460

actatggaaa cgtcagacct tcgggacgaa gagagagcct taccagcttt ggcaatggcc     5520

cactgtcagc aggaggaccc ggcaagcccg ggggaggagg gggaggttcc ggatccagct     5580

ctatgagcag gggtgagatg agtctggccg aggttcagtg tcaccttgac aaggaggggg     5640

cttccaatct agttatcgac ctcatcatga acgcatccag tgaccgagtg ttccatgaaa     5700

gcattctcct ggccattgcc cttctggaag gaggcaacac caccatccag cactcctttt     5760

tctgtcgctt gacagaagat aagaagtcag agaaattctt taaggtgttt tatgaccgga     5820

tgaaggtggc ccagcaagaa atcaaagcaa cagtgacagt gaacaccagt gacttgggaa     5880

ataaaaagaa agacgatgag gtagacaggg atgccccatc acggaaaaaa gctaaagagc     5940

ccacaacaca gataacagaa gaggtccggg atcagctcct ggaggcctcc gctgccacca     6000

ggaaagcctt caccactttc aggagggagg ctgatcccga cgaccactac cagcctggag     6060

agggcaccca ggccactgcc gacaaggcca aggacgacct ggagatgagc gcggtcatca     6120

ccatcatgca gcccatcctc cgcttccttc agctcctgtg tgaaaaccac aaccgagacc     6180

tgcagaactt cctccgttgc caaaataaca agaccaacta caatttggta tgtgagaccc     6240

tgcagtttct ggactgtatt tgtggaagca caactggagg ccttggtctt ctgggcttgt     6300

atataaatga aaagaacgta gcgcttatca accaaaccct ggaaagtctg accgaatact     6360

gtcaaggacc ttgccatgag aaccagaact gcatagccac ccatgaatcc aatggcattg     6420

acatcatcac agccctgatc ctcaatgata tcaatccttt gggaaagaag aggatggacc     6480

ttgtgttaga actgaagaac aatgcctcga agttgctcct ggccatcatg gaaagcaggc     6540

acgacagtga aaacgcagag aggatacttt ataacatgag gcccaaggaa ctggtggaag     6600

tgatcaagaa agcctacatg caaggtgaag tggaatttga ggatggagaa aacggtgagg     6660

atggggcggc gtcccccagg aacgtggggc acaacatcta catattagcc catcagttgg     6720

ctcggcataa caaagaactt cagagcatgc tgaaacctgg tggccaagtg gacggagatg     6780

aagccctgga gttttatgcc aagcacacgg cgcagataga gattgtcaga ttagaccgaa     6840

caatggaaca gatagtcttt cccgtgccca gcatatgtga attcctaacc aaggagtcaa     6900

aactacgaat ttactatact acagagagag acgaacaagg cagcaaaatc aatgatttct     6960

ttctgcggtc tgaagacctc ttcaatgaaa tgaattggca gaagaaactg agagcccagc     7020

ccgtgttgta ctggtgtgcc cgcaacatgt ctttctggag cagcatttcg tttaacctgg     7080

ccgtcctgat gaacctgctg gtggcgtttt tctacccgtt taagggagtc cgaggaggaa     7140

ccctggagcc ccactggtcg ggactcctgt ggacagccat gctcatctct ctggccatcg     7200

tcattgccct ccccaagccc catggcatcc gggccttaat tgcctccaca attctacgac     7260

tgatattttc agtcgggtta caacccacgt tgtttcttct gggcgctttc aatgtatgca     7320

ataaaatcat ctttctaatg agctttgtgg gcaactgtgg gacattcaca agaggctacc     7380

gagccatggt tctggatgtt gagttcctct atcatttgtt gtatctggtg atctgtgcca     7440

tggggctctt tgtccatgaa ttcttctaca gtctgctgct ttttgattta gtgtacagag     7500

aagagacttt gcttaatgtc attaaaagtg tcactcgcaa tggacggtcc atcatcctga     7560

cagcagttct ggctctgatc ctcgtttacc tgttctcaat agtgggctat cttttcttca     7620

aggatgactt tatcttggaa gtagataggc tgcccaatga aacagctgtt ccagaaaccg     7680

gcgagagttt ggcaagcgag ttcctgttct ccgatgtgtg tagggtggag agtggggaga     7740

actgctcctc tcctgcaccc agagaagagc tggtccctgc agaagagacg gaacaggata     7800

aagagcacac atgtgagacg ctgctgatgt gcattgtcac tgtgctgagt cacgggctgc     7860

ggagcggggg tggagtagga gatgtactca ggaagccgtc caaagaggaa cccctgtttg     7920

ctgctagagt tatttatgac ctcttgttct tcttcatggt catcatcatt gttcttaacc     7980

tgatttttgg ggttatcatt gacacttttg ctgacctgag gagtgagaag cagaagaagg     8040

aagagatctt gaagaccacg tgctttatct gtggcttgga aagagacaag tttgacaaca     8100

agactgtcac ctttgaagag cacatcaagg aagaacacaa catgtggcac tatctgtgct     8160

tcatcgtcct ggtgaaagta aaggactcca ccgaatatac tgggcctgag agttacgtgg     8220

cagaaatgat caaggaaaga aaccttgact ggttccccag gatgagagcc atgtcattgg     8280

tcagcagtga ttctgaagga gaacagaatg agctgagaaa cctgcaggag aagctggagt     8340

ccaccatgaa acttgtcacg aacctttctg gccagctgtc ggaattaaag gatcagatga     8400

cagaacaaag gaagcagaaa caaagaattg gtcttctagg acatcctcct cacatgaatg     8460

tcaacccaca acaaccagca taagcaaatg aaagaaagga attgtattta ccttttataa     8520

ttattattag tgtgggtatg gctaatgagt tctgattcac ccacgaaggt tacatttatg     8580

ctgaatacat ttgtaaatac tcagttttat actgtatgta tatgattgct actctaaagg     8640

tttggatata tgtattgtaa ttagaattgt tggcatgatg acatttcatt tgtgccaaaa     8700

atattaaaaa tgcctttttt ggaaggacta acagaaagca cctgatttgc acttgaacca     8760

gattatagat ttaaaagtat atgacatgta ttttgtattt aaaactagaa tagccagtat     8820

ttatgttttt tataaaactg tgcaatacga attatgcaat cacaatacat ttgtagctcc     8880

cgagtgtcct aaagggagtg cacttctttg aagctggtgt gttaatacta tgtaataaat     8940

ggttaacttt caaatgatgc tgctgccaaa attatattaa tagtgagttt caggcccctg     9000

ggcattttgt accatgtaat tatcctctgg tgatgctgtt tctcgttagt ggcagtagtg     9060

cctccgtctc ctagtgataa tgctccaagt ctatgaactg ttaaatcagc attcatttta     9120

agaaaagcaa ctttagtttc aaagatactt ttaagcttct aaattgatca tttaaactat     9180

ttctttaaat aagagagcca aattagaggc tcatacttta gcttgtgaag aagataatga     9240

attttttaaa gggaactttc tatgcaatgt tcaggataaa tgcatactgc tggccaatca     9300

gtgtcatctc ctgggtaaat tttgatgtcg cattataaag acatgcataa ttgatggttt     9360

ctagattatc tagtccaaac aatagagttt attttttctt catctgaacc aacatgctac     9420

agtagctaag aagtattaaa actatataca tccatataaa gatgaaatat gaactatctc     9480

attagaagtc atagttgacc acagacatgt tattcttctg aaagagccac attttggttt     9540

tatttcttgt cacatgattt cttttcttga tggatgaaaa atatgaaagg aaacttttat     9600

atctgttgcc tagttttgta catggatctc attttacaag agaatctctc tgcaaaaaaa     9660

aaaaaaacag tttaaaaatg cattgaaagc agagttctga aatgagtaaa gtttgtaaat     9720

gcatatataa aaatatttaa taaatgatgc agaatataca gtgactggtt ggtggctttc     9780

atttggcatt tgtgacttaa ctgctattcc atttatgtac tttctttagg atcagtttga     9840

agtacagtcg gtttgattac caggttaatt cagaaaatgt ttacctgatt atttaaaaaa     9900

acacttgctg ttgttatgac agctctgagg agaattatta gaacaaacat tggggagtat     9960

ttagtacaac attcattcat tcttctggat tagtgactgc cagccaggct gtcgggagcg    10020

ccctactaaa tctcctgtct cttctgcttt tactggggga tctttaattt gctgtgtgcc    10080

atgtggaagt atcgggaa                                                  10098


<210>  635
<211>  2710
<212>  PRT
<213>  Homo Sapiens

<400>  635

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val 
        915                 920                 925             


Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro 
    930                 935                 940                 


Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu 
945                 950                 955                 960 


Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile 
                965                 970                 975     


Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser 
            980                 985                 990         


Cys Leu Leu Cys Ile Phe Lys Arg  Glu Phe Asp Glu Ser  Asn Ser Gln 
        995                 1000                 1005             


Thr Ser  Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
    1010                 1015                 1020             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1025                 1030                 1035             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1040                 1045                 1050             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1055                 1060                 1065             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1070                 1075                 1080             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1085                 1090                 1095             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1100                 1105                 1110             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1115                 1120                 1125             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1130                 1135                 1140             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1145                 1150                 1155             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1160                 1165                 1170             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1175                 1180                 1185             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1190                 1195                 1200             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1205                 1210                 1215             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1220                 1225                 1230             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1235                 1240                 1245             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1250                 1255                 1260             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1295                 1300                 1305             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1310                 1315                 1320             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1340                 1345                 1350             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1355                 1360                 1365             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1685                 1690                 1695             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1700                 1705                 1710             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1715                 1720                 1725             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1730                 1735                 1740             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1745                 1750                 1755             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1760                 1765                 1770             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1775                 1780                 1785             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1790                 1795                 1800             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1805                 1810                 1815             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1820                 1825                 1830             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1835                 1840                 1845             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1850                 1855                 1860             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1865                 1870                 1875             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1880                 1885                 1890             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1895                 1900                 1905             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1910                 1915                 1920             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1925                 1930                 1935             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1940                 1945                 1950             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1955                 1960                 1965             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1970                 1975                 1980             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1985                 1990                 1995             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    2000                 2005                 2010             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2015                 2020                 2025             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2030                 2035                 2040             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2045                 2050                 2055             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2060                 2065                 2070             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2075                 2080                 2085             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2090                 2095                 2100             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2105                 2110                 2115             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2120                 2125                 2130             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2135                 2140                 2145             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2150                 2155                 2160             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2165                 2170                 2175             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2180                 2185                 2190             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2195                 2200                 2205             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2210                 2215                 2220             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2225                 2230                 2235             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2240                 2245                 2250             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2255                 2260                 2265             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2270                 2275                 2280             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2285                 2290                 2295             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2300                 2305                 2310             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2315                 2320                 2325             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2330                 2335                 2340             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2345                 2350                 2355             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2360                 2365                 2370             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2390                 2395                 2400             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2405                 2410                 2415             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2420                 2425                 2430             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2435                 2440                 2445             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2450                 2455                 2460             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2465                 2470                 2475             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2480                 2485                 2490             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2495                 2500                 2505             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2510                 2515                 2520             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2525                 2530                 2535             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2540                 2545                 2550             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2555                 2560                 2565             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2570                 2575                 2580             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2585                 2590                 2595             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2600                 2605                 2610             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2615                 2620                 2625             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2630                 2635                 2640             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2645                 2650                 2655             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2660                 2665                 2670             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2675                 2680                 2685             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2690                 2695                 2700             


Val Asn  Pro Gln Gln Pro Ala  
    2705                 2710 


<210>  636
<211>  3591
<212>  DNA
<213>  Homo Sapiens

<400>  636
ttactgggcg tatggcgtac agacacgagg ccggcgcccg ggaggcggtg ttcatccgcc       60

cgggaaaaga gcgcctgttg ctcgctgccc gcgtgtccct ggctctctcg ggaacccagc      120

gccgaaggcg aggtgggcgc gggccgaagg aggtcctggg aggtcggcgg cgcggaggga      180

tctccgcggg agccgttggg gctgttggcc tcgggctgag gtgcaaggac caggactagg      240

gcgagggcag cggtccaaga aatagaaaac aatgactggg agagcccgag ccagagccag      300

aggaagggcc cgcggtcagg agacagcgca gctggtgggc tccactgcca gtcagcaacc      360

tggttatatt cagcctaggc ctcagccgcc accagcagag ggggaattat ttggccgtgg      420

acggcagaga ggaacagcag gaggaacagc caagtcacaa ggactccaga tatctgctgg      480

atttcaggag ttatcgttag cagagagagg aggtcgtcgt agagattttc atgatcttgg      540

tgtgaataca aggcagaacc tagaccatgt taaagaatca aaaacaggtt cttcaggcat      600

tatagtaagg ttaagcacta accatttccg gctgacatcc cgtccccagt gggccttata      660

tcagtatcac attgactata acccactgat ggaagccaga agactccgtt cagctcttct      720

ttttcaacac gaagatctaa ttggaaagtg tcatgctttt gatggaacga tattattttt      780

acctaaaaga ctacagcaaa aggttactga agtttttagt aagacccgga atggagagga      840

tgtgaggata acgatcactt taacaaatga acttccacct acatcaccaa cttgtttgca      900

gttctataat attattttca ggaggctttt gaaaatcatg aatttgcaac aaattggacg      960

aaattattat aacccaaatg acccaattga tattccaagt cacaggttgg tgatttggcc     1020

tggcttcact acttccatcc ttcagtatga aaacagcatc atgctctgca ctgacgttag     1080

ccataaagtc cttcgaagtg agactgtttt ggatttcatg ttcaactttt atcatcagac     1140

agaagaacat aaatttcaag aacaagtttc caaagaacta ataggtttag ttgttcttac     1200

caagtataac aataagacat acagagtgga tgatattgac tgggaccaga atcccaagag     1260

cacctttaag aaagccgacg gctctgaagt cagcttctta gaatactaca ggaagcaata     1320

caaccaagag atcaccgact tgaagcagcc tgtcttggtc agccagccca agagaaggcg     1380

gggccctggg gggacactgc cagggcctgc catgctcatt cctgagctct gctatcttac     1440

aggtctaact gataaaatgc gtaatgattt taacgtgatg aaagacttag ccgttcatac     1500

aagactaact ccagagcaaa ggcagcgtga agtgggacga ctcattgatt acattcataa     1560

aaacgataat gttcaaaggg agcttcgaga ctggggtttg agctttgatt ccaacttact     1620

gtccttctca ggaagaattt tgcaaacaga aaagattcac caaggtggaa aaacatttga     1680

ttacaatcca caatttgcag attggtccaa agaaacaaga ggtgcaccat taattagtgt     1740

taagccacta gataactggc tgttgatcta tacgcgaaga aattatgaag cagccaattc     1800

attgatacaa aatctattta aagttacacc agccatgggc atgcaaatga gaaaagcaat     1860

aatgattgaa gtggatgaca gaactgaagc ctacttaaga gtcttacagc aaaaggtcac     1920

agcagacacc cagatagttg tctgtctgtt gtcaagtaat cggaaggaca aatacgatgc     1980

tattaaaaaa tacctgtgta cagattgccc taccccaagt cagtgtgtgg tggcccgaac     2040

cttaggcaaa cagcaaactg tcatggccat tgctacaaag attgccctac agatgaactg     2100

caagatggga ggagagctct ggagggtgga catccccctg aagctcgtga tgatcgttgg     2160

catcgattgt taccatgaca tgacagctgg gcggaggtca atcgcaggat ttgttgccag     2220

catcaatgaa gggatgaccc gctggttctc acgctgcata tttcaggata gaggacagga     2280

gctggtagat gggctcaaag tctgcctgca agcggctctg agggcttgga atagctgcaa     2340

tgagtacatg cccagccgga tcatcgtgta ccgcgatggc gtaggagacg gccagctgaa     2400

aacactggtg aactacgaag tgccacagtt tttggattgt ctaaaatcca ttggtagagg     2460

ttacaaccct agactaacgg taattgtggt gaagaaaaga gtgaacacca gattttttgc     2520

tcagtctgga ggaagacttc agaatccact tcctggaaca gttattgatg tagaggttac     2580

cagaccagaa tggtatgact tttttatcgt gagccaggct gtgagaagtg gtagtgtttc     2640

tcccacacat tacaatgtca tctatgacaa cagcggcctg aagccagacc acatacagcg     2700

cttgacctac aagctgtgcc acatctatta caactggcca ggtgtcattc gtgttcctgc     2760

tccttgccag tacgcccaca agctggcttt tcttgttggc cagagtattc acagagagcc     2820

aaatctgtca ctgtcaaacc gcctttacta cctctaacct gcagaagacg atgcagccgc     2880

ttttcttttt gaaatgactt tgggattttt ttaagctttt atttactttt tttttaactg     2940

ttatctttct ggatgaaact tgggaagggg attaggagat ctagcatttt atttctagca     3000

ttgctattca ccggcttcct tattttatac gtaaaaatta agattttata ttttatcttc     3060

ttgtttctca tagatatttt gtgagcattt ttttgtttat tttgaagaaa tgtggataag     3120

atacttggta gtataaaaca gactctctga gagtatttga aatgtgtttg gagatttact     3180

taaacgtact ttcaggagtg agcaagtcct acttataaac ctatattaac tttatttttg     3240

agatacctgt tttgaattta aaggagataa gaggcgtaaa gtaggatgct cactacaacc     3300

ataggtgggg tttcagctca tatcttaaag ataaaaggta ctattatata acctatacac     3360

aagatacagg agaaaatatg cttgattttt atttggcagg ggggctaggt tgtatgggag     3420

taaaaaaaac attgaaaatt tttaaattgt ccaaagaaac attttaagac tctttaacaa     3480

aaaaggccat gagtaaatct ctatattaac attactattt attttgtttt ggaactggga     3540

catgattcta tttgttataa aataaaattg atgtgattgt caccttattt g              3591


<210>  637
<211>  861
<212>  PRT
<213>  Homo Sapiens

<400>  637

Met Thr Gly Arg Ala Arg Ala Arg Ala Arg Gly Arg Ala Arg Gly Gln 
1               5                   10                  15      


Glu Thr Ala Gln Leu Val Gly Ser Thr Ala Ser Gln Gln Pro Gly Tyr 
            20                  25                  30          


Ile Gln Pro Arg Pro Gln Pro Pro Pro Ala Glu Gly Glu Leu Phe Gly 
        35                  40                  45              


Arg Gly Arg Gln Arg Gly Thr Ala Gly Gly Thr Ala Lys Ser Gln Gly 
    50                  55                  60                  


Leu Gln Ile Ser Ala Gly Phe Gln Glu Leu Ser Leu Ala Glu Arg Gly 
65                  70                  75                  80  


Gly Arg Arg Arg Asp Phe His Asp Leu Gly Val Asn Thr Arg Gln Asn 
                85                  90                  95      


Leu Asp His Val Lys Glu Ser Lys Thr Gly Ser Ser Gly Ile Ile Val 
            100                 105                 110         


Arg Leu Ser Thr Asn His Phe Arg Leu Thr Ser Arg Pro Gln Trp Ala 
        115                 120                 125             


Leu Tyr Gln Tyr His Ile Asp Tyr Asn Pro Leu Met Glu Ala Arg Arg 
    130                 135                 140                 


Leu Arg Ser Ala Leu Leu Phe Gln His Glu Asp Leu Ile Gly Lys Cys 
145                 150                 155                 160 


His Ala Phe Asp Gly Thr Ile Leu Phe Leu Pro Lys Arg Leu Gln Gln 
                165                 170                 175     


Lys Val Thr Glu Val Phe Ser Lys Thr Arg Asn Gly Glu Asp Val Arg 
            180                 185                 190         


Ile Thr Ile Thr Leu Thr Asn Glu Leu Pro Pro Thr Ser Pro Thr Cys 
        195                 200                 205             


Leu Gln Phe Tyr Asn Ile Ile Phe Arg Arg Leu Leu Lys Ile Met Asn 
    210                 215                 220                 


Leu Gln Gln Ile Gly Arg Asn Tyr Tyr Asn Pro Asn Asp Pro Ile Asp 
225                 230                 235                 240 


Ile Pro Ser His Arg Leu Val Ile Trp Pro Gly Phe Thr Thr Ser Ile 
                245                 250                 255     


Leu Gln Tyr Glu Asn Ser Ile Met Leu Cys Thr Asp Val Ser His Lys 
            260                 265                 270         


Val Leu Arg Ser Glu Thr Val Leu Asp Phe Met Phe Asn Phe Tyr His 
        275                 280                 285             


Gln Thr Glu Glu His Lys Phe Gln Glu Gln Val Ser Lys Glu Leu Ile 
    290                 295                 300                 


Gly Leu Val Val Leu Thr Lys Tyr Asn Asn Lys Thr Tyr Arg Val Asp 
305                 310                 315                 320 


Asp Ile Asp Trp Asp Gln Asn Pro Lys Ser Thr Phe Lys Lys Ala Asp 
                325                 330                 335     


Gly Ser Glu Val Ser Phe Leu Glu Tyr Tyr Arg Lys Gln Tyr Asn Gln 
            340                 345                 350         


Glu Ile Thr Asp Leu Lys Gln Pro Val Leu Val Ser Gln Pro Lys Arg 
        355                 360                 365             


Arg Arg Gly Pro Gly Gly Thr Leu Pro Gly Pro Ala Met Leu Ile Pro 
    370                 375                 380                 


Glu Leu Cys Tyr Leu Thr Gly Leu Thr Asp Lys Met Arg Asn Asp Phe 
385                 390                 395                 400 


Asn Val Met Lys Asp Leu Ala Val His Thr Arg Leu Thr Pro Glu Gln 
                405                 410                 415     


Arg Gln Arg Glu Val Gly Arg Leu Ile Asp Tyr Ile His Lys Asn Asp 
            420                 425                 430         


Asn Val Gln Arg Glu Leu Arg Asp Trp Gly Leu Ser Phe Asp Ser Asn 
        435                 440                 445             


Leu Leu Ser Phe Ser Gly Arg Ile Leu Gln Thr Glu Lys Ile His Gln 
    450                 455                 460                 


Gly Gly Lys Thr Phe Asp Tyr Asn Pro Gln Phe Ala Asp Trp Ser Lys 
465                 470                 475                 480 


Glu Thr Arg Gly Ala Pro Leu Ile Ser Val Lys Pro Leu Asp Asn Trp 
                485                 490                 495     


Leu Leu Ile Tyr Thr Arg Arg Asn Tyr Glu Ala Ala Asn Ser Leu Ile 
            500                 505                 510         


Gln Asn Leu Phe Lys Val Thr Pro Ala Met Gly Met Gln Met Arg Lys 
        515                 520                 525             


Ala Ile Met Ile Glu Val Asp Asp Arg Thr Glu Ala Tyr Leu Arg Val 
    530                 535                 540                 


Leu Gln Gln Lys Val Thr Ala Asp Thr Gln Ile Val Val Cys Leu Leu 
545                 550                 555                 560 


Ser Ser Asn Arg Lys Asp Lys Tyr Asp Ala Ile Lys Lys Tyr Leu Cys 
                565                 570                 575     


Thr Asp Cys Pro Thr Pro Ser Gln Cys Val Val Ala Arg Thr Leu Gly 
            580                 585                 590         


Lys Gln Gln Thr Val Met Ala Ile Ala Thr Lys Ile Ala Leu Gln Met 
        595                 600                 605             


Asn Cys Lys Met Gly Gly Glu Leu Trp Arg Val Asp Ile Pro Leu Lys 
    610                 615                 620                 


Leu Val Met Ile Val Gly Ile Asp Cys Tyr His Asp Met Thr Ala Gly 
625                 630                 635                 640 


Arg Arg Ser Ile Ala Gly Phe Val Ala Ser Ile Asn Glu Gly Met Thr 
                645                 650                 655     


Arg Trp Phe Ser Arg Cys Ile Phe Gln Asp Arg Gly Gln Glu Leu Val 
            660                 665                 670         


Asp Gly Leu Lys Val Cys Leu Gln Ala Ala Leu Arg Ala Trp Asn Ser 
        675                 680                 685             


Cys Asn Glu Tyr Met Pro Ser Arg Ile Ile Val Tyr Arg Asp Gly Val 
    690                 695                 700                 


Gly Asp Gly Gln Leu Lys Thr Leu Val Asn Tyr Glu Val Pro Gln Phe 
705                 710                 715                 720 


Leu Asp Cys Leu Lys Ser Ile Gly Arg Gly Tyr Asn Pro Arg Leu Thr 
                725                 730                 735     


Val Ile Val Val Lys Lys Arg Val Asn Thr Arg Phe Phe Ala Gln Ser 
            740                 745                 750         


Gly Gly Arg Leu Gln Asn Pro Leu Pro Gly Thr Val Ile Asp Val Glu 
        755                 760                 765             


Val Thr Arg Pro Glu Trp Tyr Asp Phe Phe Ile Val Ser Gln Ala Val 
    770                 775                 780                 


Arg Ser Gly Ser Val Ser Pro Thr His Tyr Asn Val Ile Tyr Asp Asn 
785                 790                 795                 800 


Ser Gly Leu Lys Pro Asp His Ile Gln Arg Leu Thr Tyr Lys Leu Cys 
                805                 810                 815     


His Ile Tyr Tyr Asn Trp Pro Gly Val Ile Arg Val Pro Ala Pro Cys 
            820                 825                 830         


Gln Tyr Ala His Lys Leu Ala Phe Leu Val Gly Gln Ser Ile His Arg 
        835                 840                 845             


Glu Pro Asn Leu Ser Leu Ser Asn Arg Leu Tyr Tyr Leu 
    850                 855                 860     


<210>  638
<211>  11747
<212>  DNA
<213>  Homo Sapiens

<400>  638
ttttgcagta gaagagtata accatgtttc ggaatagtct caagatgctg cttactggtg       60

ggaaatcaag tcgtaaaaac aggtcaagtg atggagggag cgaggaacca ccggatcgaa      120

gacagtcaag tgtagactct cgccaaagcc gctctgggca aggtggcatc tccacagaaa      180

gcgactgtgc ttttgagcca gactacgctg tcccgccact tccagtgagt gaaggtgatg      240

ctgaacagga gcttggcccc cctccatctg tagatgaggc agcaaacaca ctcatgactc      300

gtctgggttt cctccttgga gagaaagtca cagaagttca gccaggtgac caatacagca      360

tggaagtaca ggatgaaaat cagacctcag caatcaccca gcggataagt ccttgttcca      420

ctctgactag cagcactgcc tctccaccag ccagtagccc ctgctctaca ctcccaccca      480

tcagtacaaa tgcaactgcc aaggactgca gctatggggc tgttactagt ccaacctcta      540

cccttgaaag cagagatagt ggcatcattg ctacattaac aagctattct gaaaatgtgg      600

aacgcacaaa atatgctggg gaaagcagta aagaattagg atctggagga aacataaaac      660

cttggcagtc tcaaaaatcc agcatggact cctgtttgta tcgagtagat gaaaacatga      720

ctgcttccac ctatagtctg aataagatcc cagagagaaa tttggaaaca gtgttatctc      780

aatcagtaca gtctattcct ttgtatctca tgccacggcc aaattcagta gcagccacca      840

gctctgccca cttggaagac cttgcttacc tggatgagca gagacataca cctttgagaa      900

cttctctacg aatgccaaga cagagcatgg gtggtgctcg cacacagcag gatttaagag      960

ttcgctttgc accttatagg cctccagata tctccttgaa gcctctgctc tttgaagtgc     1020

ccagcatcac tacagagtca gtgtttgttg gccgagattg ggttttccac gaaatagatg     1080

ctcaacttca aagttcaaat gccagcgtga accaaggagt agtgattgtg ggaaacattg     1140

gattcggcaa aactgccatc atctccagac tggtggccct cagctgccat ggtacaagga     1200

tgagacagat cgcctcagac agcccacatg cctcccccaa acatgtggat gccaacagag     1260

agctgccact cacacagcca ccttcagccc actcatctat caccagtgga agctgcccag     1320

gaactccgga aatgcgcagg cggcaggagg aggctatgcg aagactagcc tcgcaggtgg     1380

ttgcctatca ctattgtcaa gcagataatg cctacacttg cttggtgcca gaatttgtcc     1440

acaatgttgc tgccttgctc tgccgctcac ctcagctgac agcctatcgg gagcagcttc     1500

ttcgggaacc tcacctgcag agcatgctga gccttcgttc ctgtgttcaa gaccccatgg     1560

cctccttccg gaggggagtt ctggagccac tagaaaatct ccataaagag agaaaaatcc     1620

cagatgaaga tttcatcatt ttaattgatg gattaaatga agcagaattt cacaaaccgg     1680

attatgggga tacaattgta tcgtttctga gtaaaatgat cggaaagttt ccttcttggc     1740

tcaaactaat tgtaacagtt aggaccagtt tacaggaaat taccaagctg ctgcctttcc     1800

ataggatttt tttggatcga ctagaagaga atgaagccat agaccaggac ctgcaggctt     1860

acatcctgca ccggatacac agcagctcag agatccagaa taacatttca cttaatggca     1920

aaatggacaa tactacattt ggcaaactca gttctcatct caagaccctc agtcaagggt     1980

cctatctata tctgaaactt acatttgacc tcatagagaa aggctatcta gtgttaaaga     2040

gctctagcta caaagtagtt cctgtttcgc tctcagaggt ttatttactc cagtgcaata     2100

tgaagttccc aacccagtct tcctttgacc gggtgatgcc tctcctgaat gtggcagtgg     2160

cctctctcca cccactgact gatgagcata tcttccaggc catcaatgct gggagcattg     2220

aaggcacact agaatgggag gattttcagc agagaatgga gaacctctcc atgttcctaa     2280

tcaagcgcag agacatgact cgtatgtttg tacatccttc ttttcgagaa tggcttatct     2340

ggagagaaga aggagagaaa accaaatttc tctgtgatcc gaggagtggt cacacgttac     2400

ttgccttctg gttttcccgc caagagggaa aactaaaccg acagcagact attgaactgg     2460

gacatcacat cctcaaagca cacattttta agggtttgag taaaaaagtt ggtgtatcat     2520

cctccatcct ccaaggtctc tggatctctt atagcacaga aggtctttcc atggcactgg     2580

cgtctttacg aaatctctac actccaaata taaaggtcag ccgactgctg attttgggag     2640

gtgccaatat taattaccgg acagaggttt taaataatgc tccaattcta tgtgttcagt     2700

cccatcttgg ttacacagaa atggtagccc tgctgctgga gttcggggcc aacgtggatg     2760

cctcttctga aagtggcctg actcccctgg gatatgctgc agcagcaggg tacctgagca     2820

ttgtggtgct gctgtgcaag aaacgggcca aggtggatca tttggataag aacgggcagt     2880

gtgctttggt tcatgctgca ctccgaggtc atctggaggt tgtcaagttt ttgattcagt     2940

gtgactggac gatggccggc cagcagcaag gagtatttaa gaagagccat gccatccaac     3000

aggccctcat tgctgcagcc agcatgggtt atactgagat tgtctcctac ctacttgatc     3060

ttccagaaaa agatgaagag gaagtagagc gagcacagat caacagcttt gacagtctct     3120

ggggagagac agccctaaca gctgcagccg gaaggggcaa actggaggtg tgccgtttgc     3180

tcttggaaca aggggcggca gtggcccagc caaaccgccg aggagcagtg ccactattca     3240

gcacagtgcg ccagggccac tggcagattg ttgatctttt actcacccat ggagctgatg     3300

tcaacatggc agacaagcag ggccgcactc ccctgatgat ggctgcttcc gaaggccatc     3360

taggaaccgt ggactttctg cttgcacaag gtgcctccat tgctcttatg gacaaagaag     3420

gattgacagc cctcagctgg gcttgtttga agggccatct ctcagtagta cgttctctgg     3480

tggataacgg agctgccaca gaccatgctg acaagaatgg ccgtacccca ctggatctgg     3540

cagctttcta tggcgatgct gaggtggtcc agttcctggt agatcatggg gccatgatcg     3600

agcacgttga ctacagtgga atgcgccctt tggatagggc agtggggtgc cggaacactt     3660

ctgttgttgt cactcttctg aagaaaggag ccaagatagg tccagccaca tgggcgatgg     3720

ccacctccaa gccagacatc atgatcatcc tgttgagcaa gctgatggaa gagggggaca     3780

tgttttataa gaaaggtaaa gtaaaggaag ctgcccagcg ctaccagtac gccctgaaga     3840

agttccctag agaagggttt ggtgaggact tgaaaacttt ccgggaacta aaggtgtctc     3900

tcctcctcaa cctctctcgg tgtcgcagga aaatgaacga ttttggaatg gcggaggaat     3960

ttgctactaa ggccctggag ctgaaaccga aatcttatga agcttactat gcgagagcaa     4020

gggcaaaacg cagcagcaga cagttcgcag cagccttaga ggacctgaac gaggccatca     4080

agctgtgtcc caacaaccgt gagatccaga gacttctgct gagagtggaa gaagagtgta     4140

gacagatgca gcagccacag cagccaccgc cgccaccgca gcctcagcag cagttgccgg     4200

aagaagcaga acctgagcca cagcatgaag acatatactc tgtacaggat atattcgagg     4260

aggagtacct ggaacaggat gttgaaaatg tttccattgg cctccagaca gaggcccggc     4320

ccagccaggg gctcccggtc atccagagcc caccctcctc tcccccgcat cgggactcag     4380

cctacatctc cagctcacct cttggctctc atcaggtttt tgacttccgg tccagtagtt     4440

ctgtaggctc tcccactaga cagacctatc agtccacctc acctgccctt tctccaactc     4500

atcagaactc acattacagg cctagcccac cacacacttc cccggctcat cagggaggat     4560

cttaccgttt cagcccccct cctgtgggag gacagggcaa agaataccca agccctcccc     4620

cttcccctct ccggagaggc cctcagtatc gggccagccc tccagctgaa agtatgagtg     4680

tctatagatc ccagtctggt tcacccgtgc gctatcagca ggaaacaagc gtcagtcagc     4740

ttcctggcag acccaaatct ccattatcca aaatggccca gcggccctac cagatgcctc     4800

agctccctgt ggcagttccc cagcaagggc tcaggctaca gcctgccaag gcccagattg     4860

tgagaagtaa ccagcccagc ccagccgtcc attcaagcac cgtcatcccc acaggagcct     4920

atggccaagt agcccattca atggccagta aataccagtc ttcacaagga gacataggag     4980

tcagccagag ccggttggtt tatcaagggt caattggggg aatcgtaggg gatggaaggc     5040

cggtgcagca tgtccaagcc agcctgagtg caggcgccat ctgtcagcat ggaggattga     5100

ccaaagagga tcttccacag cgaccttcct cagcataccg aggtggcgtg agatacagcc     5160

agacaccaca gatcggacgc agccagtcag catcctatta cccagtctgt cactcaaaac     5220

tagatctgga gcgctcctcc agccaactag gttcccctga tgtgtcgcat ttaatcagaa     5280

gacctatcag tgtcaaccct aacgaaatca aaccgcaccc gccaactccc aggccgttgc     5340

tgcattccca aagtgtaggc cttcgcttct ctccatctag caatagtatc tcctccacct     5400

ccaacctaac tccgaccttc cggccatctt cttccatcca gcaaatggag atcccactga     5460

aacctgcata tgagaggtca tgtgacgagc tgtcgccagt gtctccaact caaggaggtt     5520

accccagtga gcccacccga tccaggacca caccattcat ggggatcata gataaaacag     5580

cacggactca gcagtacccc cacctccacc agcagaatcg gacctgggca gtgtcatctg     5640

tggacaccgt cctcagtccc acgtctccag gcaacctgcc tcagcctgag tccttcagtc     5700

caccatcatc catcagcaac attgcctttt ataacaaaac caacaatgca cagaatggcc     5760

atttgctgga ggacgattat tacagccccc atgggatgct ggctaacggg tctcgtggag     5820

acctcttgga gcgagtcagc caggcctcct cctatcccga cgtgaaggta gctcggactc     5880

tacctgtggc tcaggcatac caggacaacc tgtacaggca gctgtcccga gactctcggc     5940

aagggcagac atcccctatc aaaccaaaga gaccgttcgt ggagtctaat gtttaaaaga     6000

cgttttgttg gagtgagacc catatgtttt cactgcacat tttcaggctt ggtttccaca     6060

ttcgaggtag ttctctggct taatttctca tgtagtttct gtgtggtgtt cagaggtggc     6120

agcccacatg ctgaaatcct ttgcatgcag ccgactggga agcggcctcc cgggagccag     6180

gacttcagtt tctcttgtct gtgcccagcc acatgctctc tccctctctt cagatgccaa     6240

cgaggagatt ttcgtgctgt gtgctttaac ccagggagat cagacacact ggtcagcttt     6300

ttccaggaga caatcgcttt cactgatgtt cttgttgtgt aattgtcttt ttcctttttt     6360

aaaaaataag gtgttcttgt tcgttttctt ctagaaactt tagaaagagt gcgatgcccc     6420

tttgcctttg catccttagc cagtgtcacc cacacagcca gccgcagcgc attctcatgc     6480

tgtggcccct ccccagaccg ccagcgccct gcagccacca ggtctgcagt gtgcattagg     6540

attattgctg gtcttcctag ggggtaaaag gatcagagag agaagaatta agtgctaaat     6600

tggaagaaaa ccccaatata attatgtaaa atgtcactac attgattttc caagaggcat     6660

tgtaggaaca tgtcaaaaac agccagccct ttaaatattg cagtcagcca aggaaattag     6720

atgagaattg tggctattaa gagaattcac tgagagttat tctctagatt tttagccgac     6780

aattaaccac taaaagctgc tgcttttcca gggtggggga gggaatgaat acatagaaaa     6840

acaaaaaaga ttgttctgga ttctcagtga aaggctatag gaagtctgtt ctggagacat     6900

ctacttttta gatcctgata catcactgag tgtcatactc cactaaaagg aaactctaac     6960

cgaaggctgg ctggtgtgac aatcccgtta gttggatctt cacctacagc cagattttgt     7020

tctagtggcc ctcttcctgt aaacccagat ggtgtcatac agaaattgtt tctttcagaa     7080

gcagattgga atctcttggg accatgagac tgagtcccaa tatttccacc cagggtcatg     7140

cccgttgttg tctacttcca ttttgagatc tatagtttga ttatctatta ttacaggaac     7200

tgtttctttt ctttttctag gagtgtttat gagagtgtga tattttaaag tcagacgcag     7260

caaaaactgt ttcagggtga agaaagaccc ctttcagccc tgttttgcag ccctgggtgg     7320

gggcatgaga tagacagcaa gcttctgatc ttgaagcttg tctagaagac acatcttcta     7380

ggtctcgtgg tcatttggta ggctgacctt tgagtgagcg aggccactat tgagtggata     7440

gcaagaacat tggaaccaaa gcctcggcac aggcctggca ctggctgtac atcagctctt     7500

acaactaaac aactcaacta agcaactgaa acgaaacaaa ggagcattcg ttctctgttg     7560

ttaggaatca ttctgctctg ttagggaagg gctgcaggaa gggcagtttc ctgaataaaa     7620

atctggctgc gaccagtccc atgtgtctgg taagtaagta agtaagtaag tgccctttga     7680

agggatcatt aagacacagg gagcatgaac ctgagatcag aagcatttct ttactaattt     7740

agattctgcg aaatagacgg acctctccac ccccaaacct aaaacaggcc aggacttgtc     7800

tctgtgctga aagcaaatag caagactaac tcaagcccca gcctctttcc acactccctg     7860

atacctaagg actgctttct cagctagacc agggtgggca tcagcgacgc cttctcagct     7920

agaccagggt aggcatcagc gtcctctctc catctctata cccctctctc tcacatcagg     7980

aagatgaaat gtgtagctct agcggcaacc tctagccagg agcccagtgg cctctcagat     8040

tgctttttgg ccaggtctca gcactgctgg catctttaca tcttactcct taaaaccgcc     8100

tctcgctgag gagccactgc attttgaaga atttctcagt gtctgtcagg aaagtgctcc     8160

tgctcatttg gaacgccaca caccacccgc actcacctgt ccaggcgaat gagcaggtcc     8220

tgtagcttta caaatatgcc gctgatgccg cttctcccca gggtctctca gttttccagg     8280

acaaaaagat ttagggccta taccctatgg gcaaaacacc taaaatgtca acagtcaaaa     8340

tgccattctt tttggccatc ataagaggga gtaggtatca ctgctgcatg ccagttgttt     8400

ttgactagaa tatgccaacc agagcttgtt ggggcaggag acgtttttcc ttacaagcag     8460

actgcctgtg ccctgtgccc tgtttgctac ttcactgcca tggaatgatc cgagtactgt     8520

atttcagagc tgccccttcc ccagcagcaa acactcgctg agtccatgtc tggcttcagg     8580

tgggaggaaa tgtttcagat gaaacttact caattcatac caccctgaaa tggaggacag     8640

aggtgacaaa cttcagttta ataggtttct caccaagttg tatgttccat tggcccagga     8700

ttcttgcact aatgggtttc tatcacatca tgtctataaa tgggtgcact ttactgtttg     8760

aatttgtaac tgaagtactg gatatttaag tgtgagtaat gtcttcatta gaaaatagca     8820

gaaccgctct tgtcttttag tgtatttttc aagaaaaaag gaaaggaaag acatcaagca     8880

gtggatcaca acatttatag cacaagaaat aacttgtata taagcatcaa aaagattaag     8940

aattttttaa tatgaaaaat atttgcagtg attttaaagt gcttttccag caatgttctt     9000

agggactcct gagacacggt tactttatct actggatcag taaggcacac aattaacaat     9060

taacaattaa tgtttattta caaagtaaag ggaaaacctg tgtaacatga gaatttggca     9120

tgacaaaatg gagaccattt tgtatctgct gttgtatctt gtccgggttg cagacgtgca     9180

ctattaaagt cccaagttaa tagagcacaa acccttctcg ctcctccccc atgtgcccct     9240

ctttttagat gtgtataact taaactcgat ggctcaggaa aattccacta attagaatca     9300

tgtacagtac cccaggtcgt tgtccagata tacaagtttg ctaatgtagt taagcctgga     9360

ttattaaaca cttttcctaa attattgtaa acagaacagc ttagagaaag gtattctcag     9420

tccttaatat tgtatagtag tttatgagcc cctctctaaa tattggtatt tttatattcc     9480

agagatgtac ccaatagaaa aaattaaaaa ttaatcagta tctaatttaa tatccataag     9540

tatttttcct tagattttag tcacgtacag tgggctatgt ggatgtcact tgtgcttcac     9600

catagtttac cactaggtgt cactgtggct ctgcactgcg cttgttttgt agcaaagaac     9660

agcggcatcc cctcgggaga gaggagctgc ttccagggca acaggcaagc gggctcagag     9720

gttcaggaga aggcaacaga ggcctggaag gggtcttcgt gcatctgtgc cagttgtgca     9780

agacgaactc tttgaacact acatgctttg gacttcagcc aggcagaggc tggaagaagg     9840

ttgaccagag ctcccttgct ctggtagagg gatgggtaca tggagaagcc ccttcttccc     9900

catgagcctc cctcctgtca gttcctctca gcctccagct tttataactc cagaagcgtc     9960

acagttgggt ggtttgattc agagagagtt atttttctac tgcagaaatg ccttggacaa    10020

aaccagtgct cactgaatct ttgccacaaa atggaatagg ctatcccagg gggcaagagg    10080

tgcccgcccc tgtgcccagc ctcctcttga tgctcccagt gcccagcagc ctcgcacacc    10140

ctgcctgtct gttcctgggc tgcccatttc tcaagaaacc gacctgcaaa ggcagccggc    10200

tgctgcctcc acaccgaggg ctgtgcggtc ctgctgctcg ctcactggga ggtgcagctc    10260

tttctcctct tcctctagga attccagacc gaccatctac catgactaac aacaatgaac    10320

aaagggctta ggggcaagag ctacctgcaa agacgtgtca tggaaccctt caccatgcaa    10380

tgccttgaac tcagctctgg ctgctcccaa gaaaaggtgg ctggctgggg gcctggacac    10440

aagcacaatg gggctggtgg agccactgtg cagagctact tgaataatca ctgggttttc    10500

atcaactcct tttgtcatac agaccactca agggctgaag tgttggtaac cttcatttcg    10560

gtgtccaaag cctcacagca ggtgagccac cctgagatgc ttgtggccac atggtggcca    10620

cagtcagagc tttgaaagtc agtaccaaat gaacgcataa ttggacacca aaaatcaagt    10680

gttactttca tgtttcctca ccccatcatc tcattgcctc ctgctgactc tgataccgac    10740

gctgagctga cttgccaggc tgccgctgga cgcgtagaga tcaggccagc gccgcgctca    10800

tttttccagg tagacctact ctgtggaacg gaagtgccct agctgctttg tttttgtagc    10860

acttgctggc tgaatttttc ttttgctaat cgctaaccag aaagtctggt tagagggggc    10920

tcaactcaat ccctttggtc cccagcgcca gacaagagtt aattctggaa aattcagtac    10980

ttgaatgtac ctgccttatt gcataccaat ttactggggg gaaaaaaaaa gttaagagat    11040

gccggctcca gatctccact tcattcacag gtgattttgg aaatcctgta agttacactt    11100

cctgttctgg ttttgttttg ttttttgttt cctttggctg attcctgctg agtgaggcca    11160

gttcctcatc aggctcaggg caggtgcctt ttcaggcgtg gcctcctttc catctagcac    11220

agcatctttg tctctgttct gtctcctcca aatccaagat gattttaatt agtacagaca    11280

tgtacagtct acaattaaag agtgatttgt actaatatga ttttgattct tcctcctctt    11340

tgctgtcctt tcaagacact tgctggaaaa agctttaatg cacttagttt tcctttaggt    11400

tttctatgac tcagatgtaa aggactttct ctgtacagta tattatccaa tgcatgtttg    11460

ttctctctcc tgatatattg aacaccacac agttgtgaag ccgtgcagtg gggatgcccc    11520

acaccccaca gaggcatcta cccctgtgta taaggaaaga cattttcctt tgctgtactt    11580

gcttgagcag ttttattgtc tgtacatgtg agctgtgtga gatagatgtg aaaagttcaa    11640

atgaatgcat tttcctgccc catgtataca gattgtcatc tgtacaagga actgtatgta    11700

tgaaagcaaa tgtacttatt tataaatggc taacacttgg aaaacca                  11747


<210>  639
<211>  1990
<212>  PRT
<213>  Homo Sapiens

<400>  639

Met Phe Arg Asn Ser Leu Lys Met Leu Leu Thr Gly Gly Lys Ser Ser 
1               5                   10                  15      


Arg Lys Asn Arg Ser Ser Asp Gly Gly Ser Glu Glu Pro Pro Asp Arg 
            20                  25                  30          


Arg Gln Ser Ser Val Asp Ser Arg Gln Ser Arg Ser Gly Gln Gly Gly 
        35                  40                  45              


Ile Ser Thr Glu Ser Asp Cys Ala Phe Glu Pro Asp Tyr Ala Val Pro 
    50                  55                  60                  


Pro Leu Pro Val Ser Glu Gly Asp Ala Glu Gln Glu Leu Gly Pro Pro 
65                  70                  75                  80  


Pro Ser Val Asp Glu Ala Ala Asn Thr Leu Met Thr Arg Leu Gly Phe 
                85                  90                  95      


Leu Leu Gly Glu Lys Val Thr Glu Val Gln Pro Gly Asp Gln Tyr Ser 
            100                 105                 110         


Met Glu Val Gln Asp Glu Asn Gln Thr Ser Ala Ile Thr Gln Arg Ile 
        115                 120                 125             


Ser Pro Cys Ser Thr Leu Thr Ser Ser Thr Ala Ser Pro Pro Ala Ser 
    130                 135                 140                 


Ser Pro Cys Ser Thr Leu Pro Pro Ile Ser Thr Asn Ala Thr Ala Lys 
145                 150                 155                 160 


Asp Cys Ser Tyr Gly Ala Val Thr Ser Pro Thr Ser Thr Leu Glu Ser 
                165                 170                 175     


Arg Asp Ser Gly Ile Ile Ala Thr Leu Thr Ser Tyr Ser Glu Asn Val 
            180                 185                 190         


Glu Arg Thr Lys Tyr Ala Gly Glu Ser Ser Lys Glu Leu Gly Ser Gly 
        195                 200                 205             


Gly Asn Ile Lys Pro Trp Gln Ser Gln Lys Ser Ser Met Asp Ser Cys 
    210                 215                 220                 


Leu Tyr Arg Val Asp Glu Asn Met Thr Ala Ser Thr Tyr Ser Leu Asn 
225                 230                 235                 240 


Lys Ile Pro Glu Arg Asn Leu Glu Thr Val Leu Ser Gln Ser Val Gln 
                245                 250                 255     


Ser Ile Pro Leu Tyr Leu Met Pro Arg Pro Asn Ser Val Ala Ala Thr 
            260                 265                 270         


Ser Ser Ala His Leu Glu Asp Leu Ala Tyr Leu Asp Glu Gln Arg His 
        275                 280                 285             


Thr Pro Leu Arg Thr Ser Leu Arg Met Pro Arg Gln Ser Met Gly Gly 
    290                 295                 300                 


Ala Arg Thr Gln Gln Asp Leu Arg Val Arg Phe Ala Pro Tyr Arg Pro 
305                 310                 315                 320 


Pro Asp Ile Ser Leu Lys Pro Leu Leu Phe Glu Val Pro Ser Ile Thr 
                325                 330                 335     


Thr Glu Ser Val Phe Val Gly Arg Asp Trp Val Phe His Glu Ile Asp 
            340                 345                 350         


Ala Gln Leu Gln Ser Ser Asn Ala Ser Val Asn Gln Gly Val Val Ile 
        355                 360                 365             


Val Gly Asn Ile Gly Phe Gly Lys Thr Ala Ile Ile Ser Arg Leu Val 
    370                 375                 380                 


Ala Leu Ser Cys His Gly Thr Arg Met Arg Gln Ile Ala Ser Asp Ser 
385                 390                 395                 400 


Pro His Ala Ser Pro Lys His Val Asp Ala Asn Arg Glu Leu Pro Leu 
                405                 410                 415     


Thr Gln Pro Pro Ser Ala His Ser Ser Ile Thr Ser Gly Ser Cys Pro 
            420                 425                 430         


Gly Thr Pro Glu Met Arg Arg Arg Gln Glu Glu Ala Met Arg Arg Leu 
        435                 440                 445             


Ala Ser Gln Val Val Ala Tyr His Tyr Cys Gln Ala Asp Asn Ala Tyr 
    450                 455                 460                 


Thr Cys Leu Val Pro Glu Phe Val His Asn Val Ala Ala Leu Leu Cys 
465                 470                 475                 480 


Arg Ser Pro Gln Leu Thr Ala Tyr Arg Glu Gln Leu Leu Arg Glu Pro 
                485                 490                 495     


His Leu Gln Ser Met Leu Ser Leu Arg Ser Cys Val Gln Asp Pro Met 
            500                 505                 510         


Ala Ser Phe Arg Arg Gly Val Leu Glu Pro Leu Glu Asn Leu His Lys 
        515                 520                 525             


Glu Arg Lys Ile Pro Asp Glu Asp Phe Ile Ile Leu Ile Asp Gly Leu 
    530                 535                 540                 


Asn Glu Ala Glu Phe His Lys Pro Asp Tyr Gly Asp Thr Ile Val Ser 
545                 550                 555                 560 


Phe Leu Ser Lys Met Ile Gly Lys Phe Pro Ser Trp Leu Lys Leu Ile 
                565                 570                 575     


Val Thr Val Arg Thr Ser Leu Gln Glu Ile Thr Lys Leu Leu Pro Phe 
            580                 585                 590         


His Arg Ile Phe Leu Asp Arg Leu Glu Glu Asn Glu Ala Ile Asp Gln 
        595                 600                 605             


Asp Leu Gln Ala Tyr Ile Leu His Arg Ile His Ser Ser Ser Glu Ile 
    610                 615                 620                 


Gln Asn Asn Ile Ser Leu Asn Gly Lys Met Asp Asn Thr Thr Phe Gly 
625                 630                 635                 640 


Lys Leu Ser Ser His Leu Lys Thr Leu Ser Gln Gly Ser Tyr Leu Tyr 
                645                 650                 655     


Leu Lys Leu Thr Phe Asp Leu Ile Glu Lys Gly Tyr Leu Val Leu Lys 
            660                 665                 670         


Ser Ser Ser Tyr Lys Val Val Pro Val Ser Leu Ser Glu Val Tyr Leu 
        675                 680                 685             


Leu Gln Cys Asn Met Lys Phe Pro Thr Gln Ser Ser Phe Asp Arg Val 
    690                 695                 700                 


Met Pro Leu Leu Asn Val Ala Val Ala Ser Leu His Pro Leu Thr Asp 
705                 710                 715                 720 


Glu His Ile Phe Gln Ala Ile Asn Ala Gly Ser Ile Glu Gly Thr Leu 
                725                 730                 735     


Glu Trp Glu Asp Phe Gln Gln Arg Met Glu Asn Leu Ser Met Phe Leu 
            740                 745                 750         


Ile Lys Arg Arg Asp Met Thr Arg Met Phe Val His Pro Ser Phe Arg 
        755                 760                 765             


Glu Trp Leu Ile Trp Arg Glu Glu Gly Glu Lys Thr Lys Phe Leu Cys 
    770                 775                 780                 


Asp Pro Arg Ser Gly His Thr Leu Leu Ala Phe Trp Phe Ser Arg Gln 
785                 790                 795                 800 


Glu Gly Lys Leu Asn Arg Gln Gln Thr Ile Glu Leu Gly His His Ile 
                805                 810                 815     


Leu Lys Ala His Ile Phe Lys Gly Leu Ser Lys Lys Val Gly Val Ser 
            820                 825                 830         


Ser Ser Ile Leu Gln Gly Leu Trp Ile Ser Tyr Ser Thr Glu Gly Leu 
        835                 840                 845             


Ser Met Ala Leu Ala Ser Leu Arg Asn Leu Tyr Thr Pro Asn Ile Lys 
    850                 855                 860                 


Val Ser Arg Leu Leu Ile Leu Gly Gly Ala Asn Ile Asn Tyr Arg Thr 
865                 870                 875                 880 


Glu Val Leu Asn Asn Ala Pro Ile Leu Cys Val Gln Ser His Leu Gly 
                885                 890                 895     


Tyr Thr Glu Met Val Ala Leu Leu Leu Glu Phe Gly Ala Asn Val Asp 
            900                 905                 910         


Ala Ser Ser Glu Ser Gly Leu Thr Pro Leu Gly Tyr Ala Ala Ala Ala 
        915                 920                 925             


Gly Tyr Leu Ser Ile Val Val Leu Leu Cys Lys Lys Arg Ala Lys Val 
    930                 935                 940                 


Asp His Leu Asp Lys Asn Gly Gln Cys Ala Leu Val His Ala Ala Leu 
945                 950                 955                 960 


Arg Gly His Leu Glu Val Val Lys Phe Leu Ile Gln Cys Asp Trp Thr 
                965                 970                 975     


Met Ala Gly Gln Gln Gln Gly Val Phe Lys Lys Ser His Ala Ile Gln 
            980                 985                 990         


Gln Ala Leu Ile Ala Ala Ala Ser  Met Gly Tyr Thr Glu  Ile Val Ser 
        995                 1000                 1005             


Tyr Leu  Leu Asp Leu Pro Glu  Lys Asp Glu Glu Glu  Val Glu Arg 
    1010                 1015                 1020             


Ala Gln  Ile Asn Ser Phe Asp  Ser Leu Trp Gly Glu  Thr Ala Leu 
    1025                 1030                 1035             


Thr Ala  Ala Ala Gly Arg Gly  Lys Leu Glu Val Cys  Arg Leu Leu 
    1040                 1045                 1050             


Leu Glu  Gln Gly Ala Ala Val  Ala Gln Pro Asn Arg  Arg Gly Ala 
    1055                 1060                 1065             


Val Pro  Leu Phe Ser Thr Val  Arg Gln Gly His Trp  Gln Ile Val 
    1070                 1075                 1080             


Asp Leu  Leu Leu Thr His Gly  Ala Asp Val Asn Met  Ala Asp Lys 
    1085                 1090                 1095             


Gln Gly  Arg Thr Pro Leu Met  Met Ala Ala Ser Glu  Gly His Leu 
    1100                 1105                 1110             


Gly Thr  Val Asp Phe Leu Leu  Ala Gln Gly Ala Ser  Ile Ala Leu 
    1115                 1120                 1125             


Met Asp  Lys Glu Gly Leu Thr  Ala Leu Ser Trp Ala  Cys Leu Lys 
    1130                 1135                 1140             


Gly His  Leu Ser Val Val Arg  Ser Leu Val Asp Asn  Gly Ala Ala 
    1145                 1150                 1155             


Thr Asp  His Ala Asp Lys Asn  Gly Arg Thr Pro Leu  Asp Leu Ala 
    1160                 1165                 1170             


Ala Phe  Tyr Gly Asp Ala Glu  Val Val Gln Phe Leu  Val Asp His 
    1175                 1180                 1185             


Gly Ala  Met Ile Glu His Val  Asp Tyr Ser Gly Met  Arg Pro Leu 
    1190                 1195                 1200             


Asp Arg  Ala Val Gly Cys Arg  Asn Thr Ser Val Val  Val Thr Leu 
    1205                 1210                 1215             


Leu Lys  Lys Gly Ala Lys Ile  Gly Pro Ala Thr Trp  Ala Met Ala 
    1220                 1225                 1230             


Thr Ser  Lys Pro Asp Ile Met  Ile Ile Leu Leu Ser  Lys Leu Met 
    1235                 1240                 1245             


Glu Glu  Gly Asp Met Phe Tyr  Lys Lys Gly Lys Val  Lys Glu Ala 
    1250                 1255                 1260             


Ala Gln  Arg Tyr Gln Tyr Ala  Leu Lys Lys Phe Pro  Arg Glu Gly 
    1265                 1270                 1275             


Phe Gly  Glu Asp Leu Lys Thr  Phe Arg Glu Leu Lys  Val Ser Leu 
    1280                 1285                 1290             


Leu Leu  Asn Leu Ser Arg Cys  Arg Arg Lys Met Asn  Asp Phe Gly 
    1295                 1300                 1305             


Met Ala  Glu Glu Phe Ala Thr  Lys Ala Leu Glu Leu  Lys Pro Lys 
    1310                 1315                 1320             


Ser Tyr  Glu Ala Tyr Tyr Ala  Arg Ala Arg Ala Lys  Arg Ser Ser 
    1325                 1330                 1335             


Arg Gln  Phe Ala Ala Ala Leu  Glu Asp Leu Asn Glu  Ala Ile Lys 
    1340                 1345                 1350             


Leu Cys  Pro Asn Asn Arg Glu  Ile Gln Arg Leu Leu  Leu Arg Val 
    1355                 1360                 1365             


Glu Glu  Glu Cys Arg Gln Met  Gln Gln Pro Gln Gln  Pro Pro Pro 
    1370                 1375                 1380             


Pro Pro  Gln Pro Gln Gln Gln  Leu Pro Glu Glu Ala  Glu Pro Glu 
    1385                 1390                 1395             


Pro Gln  His Glu Asp Ile Tyr  Ser Val Gln Asp Ile  Phe Glu Glu 
    1400                 1405                 1410             


Glu Tyr  Leu Glu Gln Asp Val  Glu Asn Val Ser Ile  Gly Leu Gln 
    1415                 1420                 1425             


Thr Glu  Ala Arg Pro Ser Gln  Gly Leu Pro Val Ile  Gln Ser Pro 
    1430                 1435                 1440             


Pro Ser  Ser Pro Pro His Arg  Asp Ser Ala Tyr Ile  Ser Ser Ser 
    1445                 1450                 1455             


Pro Leu  Gly Ser His Gln Val  Phe Asp Phe Arg Ser  Ser Ser Ser 
    1460                 1465                 1470             


Val Gly  Ser Pro Thr Arg Gln  Thr Tyr Gln Ser Thr  Ser Pro Ala 
    1475                 1480                 1485             


Leu Ser  Pro Thr His Gln Asn  Ser His Tyr Arg Pro  Ser Pro Pro 
    1490                 1495                 1500             


His Thr  Ser Pro Ala His Gln  Gly Gly Ser Tyr Arg  Phe Ser Pro 
    1505                 1510                 1515             


Pro Pro  Val Gly Gly Gln Gly  Lys Glu Tyr Pro Ser  Pro Pro Pro 
    1520                 1525                 1530             


Ser Pro  Leu Arg Arg Gly Pro  Gln Tyr Arg Ala Ser  Pro Pro Ala 
    1535                 1540                 1545             


Glu Ser  Met Ser Val Tyr Arg  Ser Gln Ser Gly Ser  Pro Val Arg 
    1550                 1555                 1560             


Tyr Gln  Gln Glu Thr Ser Val  Ser Gln Leu Pro Gly  Arg Pro Lys 
    1565                 1570                 1575             


Ser Pro  Leu Ser Lys Met Ala  Gln Arg Pro Tyr Gln  Met Pro Gln 
    1580                 1585                 1590             


Leu Pro  Val Ala Val Pro Gln  Gln Gly Leu Arg Leu  Gln Pro Ala 
    1595                 1600                 1605             


Lys Ala  Gln Ile Val Arg Ser  Asn Gln Pro Ser Pro  Ala Val His 
    1610                 1615                 1620             


Ser Ser  Thr Val Ile Pro Thr  Gly Ala Tyr Gly Gln  Val Ala His 
    1625                 1630                 1635             


Ser Met  Ala Ser Lys Tyr Gln  Ser Ser Gln Gly Asp  Ile Gly Val 
    1640                 1645                 1650             


Ser Gln  Ser Arg Leu Val Tyr  Gln Gly Ser Ile Gly  Gly Ile Val 
    1655                 1660                 1665             


Gly Asp  Gly Arg Pro Val Gln  His Val Gln Ala Ser  Leu Ser Ala 
    1670                 1675                 1680             


Gly Ala  Ile Cys Gln His Gly  Gly Leu Thr Lys Glu  Asp Leu Pro 
    1685                 1690                 1695             


Gln Arg  Pro Ser Ser Ala Tyr  Arg Gly Gly Val Arg  Tyr Ser Gln 
    1700                 1705                 1710             


Thr Pro  Gln Ile Gly Arg Ser  Gln Ser Ala Ser Tyr  Tyr Pro Val 
    1715                 1720                 1725             


Cys His  Ser Lys Leu Asp Leu  Glu Arg Ser Ser Ser  Gln Leu Gly 
    1730                 1735                 1740             


Ser Pro  Asp Val Ser His Leu  Ile Arg Arg Pro Ile  Ser Val Asn 
    1745                 1750                 1755             


Pro Asn  Glu Ile Lys Pro His  Pro Pro Thr Pro Arg  Pro Leu Leu 
    1760                 1765                 1770             


His Ser  Gln Ser Val Gly Leu  Arg Phe Ser Pro Ser  Ser Asn Ser 
    1775                 1780                 1785             


Ile Ser  Ser Thr Ser Asn Leu  Thr Pro Thr Phe Arg  Pro Ser Ser 
    1790                 1795                 1800             


Ser Ile  Gln Gln Met Glu Ile  Pro Leu Lys Pro Ala  Tyr Glu Arg 
    1805                 1810                 1815             


Ser Cys  Asp Glu Leu Ser Pro  Val Ser Pro Thr Gln  Gly Gly Tyr 
    1820                 1825                 1830             


Pro Ser  Glu Pro Thr Arg Ser  Arg Thr Thr Pro Phe  Met Gly Ile 
    1835                 1840                 1845             


Ile Asp  Lys Thr Ala Arg Thr  Gln Gln Tyr Pro His  Leu His Gln 
    1850                 1855                 1860             


Gln Asn  Arg Thr Trp Ala Val  Ser Ser Val Asp Thr  Val Leu Ser 
    1865                 1870                 1875             


Pro Thr  Ser Pro Gly Asn Leu  Pro Gln Pro Glu Ser  Phe Ser Pro 
    1880                 1885                 1890             


Pro Ser  Ser Ile Ser Asn Ile  Ala Phe Tyr Asn Lys  Thr Asn Asn 
    1895                 1900                 1905             


Ala Gln  Asn Gly His Leu Leu  Glu Asp Asp Tyr Tyr  Ser Pro His 
    1910                 1915                 1920             


Gly Met  Leu Ala Asn Gly Ser  Arg Gly Asp Leu Leu  Glu Arg Val 
    1925                 1930                 1935             


Ser Gln  Ala Ser Ser Tyr Pro  Asp Val Lys Val Ala  Arg Thr Leu 
    1940                 1945                 1950             


Pro Val  Ala Gln Ala Tyr Gln  Asp Asn Leu Tyr Arg  Gln Leu Ser 
    1955                 1960                 1965             


Arg Asp  Ser Arg Gln Gly Gln  Thr Ser Pro Ile Lys  Pro Lys Arg 
    1970                 1975                 1980             


Pro Phe  Val Glu Ser Asn Val  
    1985                 1990 


<210>  640
<211>  2021
<212>  DNA
<213>  Homo Sapiens

<400>  640
gcagggattt ggcaacctca gagccgcgag gaggaggcgg agtcgcggag agtttgagta       60

tttccgtcca atcaaaagga gactgtaaga ggaggaggag gaggagatga ctggggagcg      120

ggagctggag aatactgccc agttactcta gcgcgccagg ccgaaccgca gcttcttggc      180

ttaggtactt ctactcacag cggccgattc cgaggccaac tccagcaatg gcttttgcaa      240

atctgcggaa agtgctcatc agtgacagcc tggacccttg ctgccggaag atcttgcaag      300

atggagggct gcaggtggtg gaaaagcaga accttagcaa agaggagctg atagcggagc      360

tgcaggactg tgaaggcctt attgttcgct ctgccaccaa ggtgaccgct gatgtcatca      420

acgcagctga gaaactccag gtggtgggca gggctggcac aggtgtggac aatgtggatc      480

tggaggccgc aacaaggaag ggcatcttgg ttatgaacac ccccaatggg aacagcctca      540

gtgccgcaga actcacttgt ggaatgatca tgtgcctggc caggcagatt ccccaggcga      600

cggcttcgat gaaggacggc aaatgggagc ggaagaagtt catgggaaca gagctgaatg      660

gaaagaccct gggaattctt ggcctgggca ggattgggag agaggtagct acccggatgc      720

agtcctttgg gatgaagact atagggtatg accccatcat ttccccagag gtctcggcct      780

cctttggtgt tcagcagctg cccctggagg agatctggcc tctctgtgat ttcatcactg      840

tgcacactcc tctcctgccc tccacgacag gcttgctgaa tgacaacacc tttgcccagt      900

gcaagaaggg ggtgcgtgtg gtgaactgtg cccgtggagg gatcgtggac gaaggcgccc      960

tgctccgggc cctgcagtct ggccagtgtg ccggggctgc actggacgtg tttacggaag     1020

agccgccacg ggaccgggcc ttggtggacc atgagaatgt catcagctgt ccccacctgg     1080

gtgccagcac caaggaggct cagagccgct gtggggagga aattgctgtt cagttcgtgg     1140

acatggtgaa ggggaaatct ctcacggggg ttgtgaatgc ccaggccctt accagtgcct     1200

tctctccaca caccaagcct tggattggtc tggcagaagc tctggggaca ctgatgcgag     1260

cctgggctgg gtcccccaaa gggaccatcc aggtgataac acagggaaca tccctgaaga     1320

atgctgggaa ctgcctaagc cccgcagtca ttgtcggcct cctgaaagag gcttccaagc     1380

aggcggatgt gaacttggtg aacgctaagc tgctggtgaa agaggctggc ctcaatgtca     1440

ccacctccca cagccctgct gcaccagggg agcaaggctt cggggaatgc ctcctggccg     1500

tggccctggc aggcgcccct taccaggctg tgggcttggt ccaaggcact acgcctgtac     1560

tgcaggggct caatggagct gtcttcaggc cagaagtgcc tctccgcagg gacctgcccc     1620

tgctcctatt ccggactcag acctctgacc ctgcaatgct gcctaccatg attggcctcc     1680

tggcagaggc aggcgtgcgg ctgctgtcct accagacttc actggtgtca gatggggaga     1740

cctggcacgt catgggcatc tcctccttgc tgcccagcct ggaagcgtgg aagcagcatg     1800

tgactgaagc cttccagttc cacttctaac cttggagctc actggtccct gcctctgggg     1860

cttttctgaa gaaacccacc cactgtgatc aatagggaga gaaaatccac attcttgggc     1920

tgaacgcggg cctctgacac tgcttacact gcactctgac cctgtagtac agcaataacc     1980

gtctaataaa gagcctaccc ccaactcctt ctgcaaaaaa a                         2021


<210>  641
<211>  533
<212>  PRT
<213>  Homo Sapiens

<400>  641

Met Ala Phe Ala Asn Leu Arg Lys Val Leu Ile Ser Asp Ser Leu Asp 
1               5                   10                  15      


Pro Cys Cys Arg Lys Ile Leu Gln Asp Gly Gly Leu Gln Val Val Glu 
            20                  25                  30          


Lys Gln Asn Leu Ser Lys Glu Glu Leu Ile Ala Glu Leu Gln Asp Cys 
        35                  40                  45              


Glu Gly Leu Ile Val Arg Ser Ala Thr Lys Val Thr Ala Asp Val Ile 
    50                  55                  60                  


Asn Ala Ala Glu Lys Leu Gln Val Val Gly Arg Ala Gly Thr Gly Val 
65                  70                  75                  80  


Asp Asn Val Asp Leu Glu Ala Ala Thr Arg Lys Gly Ile Leu Val Met 
                85                  90                  95      


Asn Thr Pro Asn Gly Asn Ser Leu Ser Ala Ala Glu Leu Thr Cys Gly 
            100                 105                 110         


Met Ile Met Cys Leu Ala Arg Gln Ile Pro Gln Ala Thr Ala Ser Met 
        115                 120                 125             


Lys Asp Gly Lys Trp Glu Arg Lys Lys Phe Met Gly Thr Glu Leu Asn 
    130                 135                 140                 


Gly Lys Thr Leu Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg Glu Val 
145                 150                 155                 160 


Ala Thr Arg Met Gln Ser Phe Gly Met Lys Thr Ile Gly Tyr Asp Pro 
                165                 170                 175     


Ile Ile Ser Pro Glu Val Ser Ala Ser Phe Gly Val Gln Gln Leu Pro 
            180                 185                 190         


Leu Glu Glu Ile Trp Pro Leu Cys Asp Phe Ile Thr Val His Thr Pro 
        195                 200                 205             


Leu Leu Pro Ser Thr Thr Gly Leu Leu Asn Asp Asn Thr Phe Ala Gln 
    210                 215                 220                 


Cys Lys Lys Gly Val Arg Val Val Asn Cys Ala Arg Gly Gly Ile Val 
225                 230                 235                 240 


Asp Glu Gly Ala Leu Leu Arg Ala Leu Gln Ser Gly Gln Cys Ala Gly 
                245                 250                 255     


Ala Ala Leu Asp Val Phe Thr Glu Glu Pro Pro Arg Asp Arg Ala Leu 
            260                 265                 270         


Val Asp His Glu Asn Val Ile Ser Cys Pro His Leu Gly Ala Ser Thr 
        275                 280                 285             


Lys Glu Ala Gln Ser Arg Cys Gly Glu Glu Ile Ala Val Gln Phe Val 
    290                 295                 300                 


Asp Met Val Lys Gly Lys Ser Leu Thr Gly Val Val Asn Ala Gln Ala 
305                 310                 315                 320 


Leu Thr Ser Ala Phe Ser Pro His Thr Lys Pro Trp Ile Gly Leu Ala 
                325                 330                 335     


Glu Ala Leu Gly Thr Leu Met Arg Ala Trp Ala Gly Ser Pro Lys Gly 
            340                 345                 350         


Thr Ile Gln Val Ile Thr Gln Gly Thr Ser Leu Lys Asn Ala Gly Asn 
        355                 360                 365             


Cys Leu Ser Pro Ala Val Ile Val Gly Leu Leu Lys Glu Ala Ser Lys 
    370                 375                 380                 


Gln Ala Asp Val Asn Leu Val Asn Ala Lys Leu Leu Val Lys Glu Ala 
385                 390                 395                 400 


Gly Leu Asn Val Thr Thr Ser His Ser Pro Ala Ala Pro Gly Glu Gln 
                405                 410                 415     


Gly Phe Gly Glu Cys Leu Leu Ala Val Ala Leu Ala Gly Ala Pro Tyr 
            420                 425                 430         


Gln Ala Val Gly Leu Val Gln Gly Thr Thr Pro Val Leu Gln Gly Leu 
        435                 440                 445             


Asn Gly Ala Val Phe Arg Pro Glu Val Pro Leu Arg Arg Asp Leu Pro 
    450                 455                 460                 


Leu Leu Leu Phe Arg Thr Gln Thr Ser Asp Pro Ala Met Leu Pro Thr 
465                 470                 475                 480 


Met Ile Gly Leu Leu Ala Glu Ala Gly Val Arg Leu Leu Ser Tyr Gln 
                485                 490                 495     


Thr Ser Leu Val Ser Asp Gly Glu Thr Trp His Val Met Gly Ile Ser 
            500                 505                 510         


Ser Leu Leu Pro Ser Leu Glu Ala Trp Lys Gln His Val Thr Glu Ala 
        515                 520                 525             


Phe Gln Phe His Phe 
    530             


<210>  642
<211>  2346
<212>  DNA
<213>  Homo Sapiens

<400>  642
agaccgaacc cgagggcgcc cagggcgccg agggcgggac tggactcggc ttgggcgtga       60

gatggcggcg gcagcggtga gcagcgccaa gcggagcctg cggggagagc tgaagcagcg      120

tctgcgggcg atgagtgccg aggagcggct acgccagtcc cgcgtactga gccagaaggt      180

gattgcccac agtgagtatc aaaagtccaa aagaatttcc atctttctga gcatgcaaga      240

tgaaattgag acagaagaga tcatcaagga cattttccaa cgaggcaaaa tctgcttcat      300

ccctcggtac cggttccaga gcaatcacat ggatatggtg agaatagaat caccagagga      360

aatttcttta cttcccaaaa catcctggaa tatccctcag cctggtgagg gtgatgttcg      420

ggaggaggcc ttgtccacag ggggacttga tctcatcttc atgccaggcc ttgggtttga      480

caaacatggc aaccgactgg ggaggggcaa gggctactat gatgcctatc tgaagcgctg      540

tttgcagcat caggaagtga agccctacac cctggcgttg gctttcaaag aacagatttg      600

cctccaggtc ccagtgaatg aaaacgacat gaaggtagat gaagtccttt acgaagactc      660

gtcaacagct taaatctgga ttactacagc caaataatca gtgttttata tgagagtaaa      720

gcaaagtatg tgtatttttc ccttgtcaaa aattagttga aattgttcat taatgtgaat      780

acagactgca ttttaaaatt gtaattatga aataccttat ataaaaccat ctttaaaaac      840

caatagaagt gtgaatagta gaatattaat taaaatggag gctatcagcc tgtgattttc      900

agcttaactt cctggtgtta atgtgacaag ttgatctgtc tactttgcaa tttaagttaa      960

atatttatga ggaactgtgc tccgactgag tgcgagagga aggtaaactt gcgggagtgg     1020

gcactgtatt tcattacgcc tttcatgacc tggtctgtcc tggcaggcac atggagactt     1080

ggggactatt aatttatttg ttggtatttg ctttggatac agaattccct aagaatatta     1140

tctcacttca tcatgacttc ctttacccac tctagaattt tatgttggac actttgtagc     1200

ttttggtggt tagtggaggg aaacctttta tgatttaaat acttttactc cactgattgg     1260

ttaccatcac tgcatgtatc agcccttgat gagtttaaga tctagtatct tataagttag     1320

aaattatttc tgtttactca tggtttctgc tttggaaatg aaatttgctg tgagttgaaa     1380

gttggcagat ggcaacacag ctagggagca ataattttgt tgtggggagg atttggtcat     1440

ctccagaaac ccgggagtca cgtggctctc ttactcacac tccatgtcca tcctgtcacc     1500

aggtcttgtt gattttgcct ctgaaatgcc tcttaaatct attctctcct ttcaattttc     1560

ctgtcactcc ttttgtccag ccttttagca tttctaagct ggactaggcg agagtgtcac     1620

acctgcttcc cttggcttcc atcttgcctc ttccagttta tttctcaagc tgcagtcaaa     1680

ctgatcttag aaaacacgaa tctaatcatg cagcacccct gactaaggtc ttccggtggc     1740

tgttcagagc ctcttgggta gcaaacagat ggcttctgtt gtatacaaag ccccttaaga     1800

gaggtctcct catctacttt ttctagcctc ttctctccca actctgtatt ctcctgtaac     1860

actgactgag cactgcaggc ttctgccctt tgcacatagt aagcatgcat ttctctctgt     1920

ctgaaatgct ctttctgttg ttcatctaga agactgtttt cccttgaaga ctcagcccta     1980

gcatcacctc ttctgtgaag tcttctgcta ctttcccaag cagagtgagt gttccttccc     2040

ttgtctgagt ggccttggcc attgatgtgc ttatcatgtt gtcttacgta tcaaattatt     2100

tgttgtcata tctgtcccct tcaccatact gtgagctcca aagaaaagaa gtgatcttta     2160

tacttcttat gcttagtaca caactagaca tatagtgtgt gtgtgagaga gagaattttt     2220

taatgaaata attgaataca ttggaagtgt ttcattcaaa atactcatcc attattcttt     2280

ggatagtagc ataaatttga tgttttatgt acaaaagtaa aaacatttga aaaataaaaa     2340

aaaaaa                                                                2346


<210>  643
<211>  203
<212>  PRT
<213>  Homo Sapiens

<400>  643

Met Ala Ala Ala Ala Val Ser Ser Ala Lys Arg Ser Leu Arg Gly Glu 
1               5                   10                  15      


Leu Lys Gln Arg Leu Arg Ala Met Ser Ala Glu Glu Arg Leu Arg Gln 
            20                  25                  30          


Ser Arg Val Leu Ser Gln Lys Val Ile Ala His Ser Glu Tyr Gln Lys 
        35                  40                  45              


Ser Lys Arg Ile Ser Ile Phe Leu Ser Met Gln Asp Glu Ile Glu Thr 
    50                  55                  60                  


Glu Glu Ile Ile Lys Asp Ile Phe Gln Arg Gly Lys Ile Cys Phe Ile 
65                  70                  75                  80  


Pro Arg Tyr Arg Phe Gln Ser Asn His Met Asp Met Val Arg Ile Glu 
                85                  90                  95      


Ser Pro Glu Glu Ile Ser Leu Leu Pro Lys Thr Ser Trp Asn Ile Pro 
            100                 105                 110         


Gln Pro Gly Glu Gly Asp Val Arg Glu Glu Ala Leu Ser Thr Gly Gly 
        115                 120                 125             


Leu Asp Leu Ile Phe Met Pro Gly Leu Gly Phe Asp Lys His Gly Asn 
    130                 135                 140                 


Arg Leu Gly Arg Gly Lys Gly Tyr Tyr Asp Ala Tyr Leu Lys Arg Cys 
145                 150                 155                 160 


Leu Gln His Gln Glu Val Lys Pro Tyr Thr Leu Ala Leu Ala Phe Lys 
                165                 170                 175     


Glu Gln Ile Cys Leu Gln Val Pro Val Asn Glu Asn Asp Met Lys Val 
            180                 185                 190         


Asp Glu Val Leu Tyr Glu Asp Ser Ser Thr Ala 
        195                 200             


<210>  644
<211>  3341
<212>  DNA
<213>  Homo Sapiens

<400>  644
ggaaggcaga agcaatctct gccgagagag tcagccgagc ggccgcgcgg agaggagggg       60

cgggcggtcc ccaggcgggc gggtgcaggg cgcagggcgc cgacctgctg gagagggggc      120

ccgggcgcga ggcggagtcc cggcgcgcag ccaggctggt ggaggccccc ggcaggctgc      180

agattccctc cggctccggg agccgcagca ggaccggcca ggaggcgcca tggaggggag      240

ccccatcccg gtgctgacag tgcccaccgc gccctacgag gaccagcggc cggccggcgg      300

cgggggtctg cggcgaccca ccggcctctt cgagggccag cgcaactacc tgcccaactt      360

tatccagagc gtgctgtcgt ccatcgacct gcgcgaccgt cagggctgca ccatggtggt      420

gggcagcgac ggcaggtact ttagcaggac ggccatcgag atcgtggtgc agatggccgc      480

ggccaacggg attggacgac tgattattgg acagaatggc atcttgtcga cacctgcggt      540

ctcctgcatt atcaggaaga tcaaggcagc tggtggaatc attctaacag ccagccactg      600

ccctggagga ccagggggag agtttggagt gaagtttaat gttgccaatg gaggtcctgc      660

acccgatgtt gtctcagaca aaatctacca aatcagcaaa acgattgagg aatatgctat      720

atgtcctgat ctccgaatcg acctatctcg actaggaaga caagaatttg acctagaaaa      780

caaattcaaa ccattcagag tggagatagt ggacccagtg gatatctatc ttaacctcct      840

tcggaccatc tttgactttc atgccatcaa gggtttgctg actggaccca gccaactgaa      900

gattcgcatt gacgcaatgc acggagttat gggaccttat gtgagaaaag ttctgtgtga      960

tgagctgggg gccccagcca attctgcaat aaactgtgtt cccctggaag actttggagg     1020

gcagcaccct gacccaaacc tgacatatgc aacgactctt ctggaagcaa tgaaaggagg     1080

agaatatgga tttggagctg catttgatgc tgatggggac cgttatatga tcctaggcca     1140

aaatggcttc tttgtgagcc cttctgactc cctggccatc attgctgcca acctctcttg     1200

cattccatat ttccgtcaga tgggggtccg cgggtttggg aggagtatgc caaccagcat     1260

ggccctggac agagtggcca aatcaatgaa ggtccctgta tatgagaccc cagctggatg     1320

gagattcttc tcaaatctga tggactcagg acgttgcaat ctgtgtgggg aagagagctt     1380

tggcactggc tctgaccacc tccgagagaa ggatggcctg tgggctgtct tggtctggct     1440

ctccattatt gctgcccgga agcagagtgt ggaggaaatt gtccgagatc actgggccaa     1500

atttggccgc cactactatt gcaggtttga ctatgagggg ttggatccca agacgacata     1560

ttatatcatg agggacctgg aggccctggt cacagacaaa tccttcattg gccagcagtt     1620

tgctgtgggg agccatgtct acagcgtggc gaagacggat agttttgaat acgtggaccc     1680

tgtggatggc actgtgacca agaaacaggg cctaaggatc attttctcgg atgcatcacg     1740

gctcatcttc cggctcagtt cctccagtgg tgtgcgggcc accctcagac tgtacgcaga     1800

gagctacgag agggatccca gcggccatga ccaggagcca caggcagtgc tgagccctct     1860

catagccatc gcactgaaaa tatcccagat tcatgagaga actggccgga ggggacccac     1920

tgtcatcacc tgaatagagg aaagatcact caccagggcc aaagagagtg ctcagcggga     1980

gatgcttcac tgatgccttc ttgctacctg tttgtgcctc ttatgacttt ggaaaaacaa     2040

aagatatttt gcttttgggg gatagagggt gggtgggaaa agaaaaaaaa tccatttggt     2100

tttggttttg tcctattcct ccaaatgcag cagggccttt agttgtctgt taaagctgca     2160

ctataatttg gtatctacat tttatcacac aaaggaacct ccccttttga caacaactgg     2220

gctaggcagc tgttaatcac aacatttgtg catcacttgt gccaagtgag aaaatgttct     2280

aaaatcacaa gagagaacag tgccagaatg aaactgaccc taagtcccag gtgcccctgg     2340

gcaggcagaa ggagacactc ccagcatgga ggagggttta tcttttcatc ctaggtcagg     2400

tctacaatgg gggaaggttt tattatagaa ctcccaacag cccacctcac tcctgccacc     2460

cacccgatgg ccctgcctcc cccatcccat ccccaacatc cctgtaccac cttctctcac     2520

atcttctaaa gctttgtaca aatcacaatg gtgcacttcc aacaaaatat atcaataggt     2580

gttttcctct cttattttgt aaatagtatt attttagcta ttaagctgga taccttcttt     2640

caaattcagc cattcagttg taaagttggg aagaagtttc ttgacaagac tctgcaatta     2700

aatgcttaaa atttggaggg gatccttcct tgattacatc aagtatgttg gtacatgggt     2760

ttatacaagt tcctcttgag aaggcaaaaa gaccaccatg tgtgagagct ctttgacttg     2820

gccaataggg gcctatctta atgcacttgt ttggacacat ttctgatctt atttgtaaag     2880

gctgcaaaag gagaggatga aatgctgtaa aagtaggaaa tgaagtggaa gctggaagaa     2940

aatgtaattg gtggtacagc tatgggccag atggtggagg ggagggtggg gacccctgcc     3000

ggcaagcaga gtgtcacagc tggctttcct cacttgggaa aagggtactg ccggtctagc     3060

agcctcctct gtactcagcc aggacaccca gcgcgtggga cctgtttgtg tctgttttgc     3120

ttccttggga acggcacagt cactcaccct gccatttgcg gaaatgacct ggtgcacttt     3180

gactgttaag caatgcgtta ttgctgtagt caaggttagt gcaagcaagg aaacattccc     3240

agtaaggtat ttgtttccat tttctgtctg tgcttctgtc agaaacttgc taggacattt     3300

agtggccaat aaaaaagaaa ttcctaattt caaccttaaa a                         3341


<210>  645
<211>  567
<212>  PRT
<213>  Homo Sapiens

<400>  645

Met Glu Gly Ser Pro Ile Pro Val Leu Thr Val Pro Thr Ala Pro Tyr 
1               5                   10                  15      


Glu Asp Gln Arg Pro Ala Gly Gly Gly Gly Leu Arg Arg Pro Thr Gly 
            20                  25                  30          


Leu Phe Glu Gly Gln Arg Asn Tyr Leu Pro Asn Phe Ile Gln Ser Val 
        35                  40                  45              


Leu Ser Ser Ile Asp Leu Arg Asp Arg Gln Gly Cys Thr Met Val Val 
    50                  55                  60                  


Gly Ser Asp Gly Arg Tyr Phe Ser Arg Thr Ala Ile Glu Ile Val Val 
65                  70                  75                  80  


Gln Met Ala Ala Ala Asn Gly Ile Gly Arg Leu Ile Ile Gly Gln Asn 
                85                  90                  95      


Gly Ile Leu Ser Thr Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys 
            100                 105                 110         


Ala Ala Gly Gly Ile Ile Leu Thr Ala Ser His Cys Pro Gly Gly Pro 
        115                 120                 125             


Gly Gly Glu Phe Gly Val Lys Phe Asn Val Ala Asn Gly Gly Pro Ala 
    130                 135                 140                 


Pro Asp Val Val Ser Asp Lys Ile Tyr Gln Ile Ser Lys Thr Ile Glu 
145                 150                 155                 160 


Glu Tyr Ala Ile Cys Pro Asp Leu Arg Ile Asp Leu Ser Arg Leu Gly 
                165                 170                 175     


Arg Gln Glu Phe Asp Leu Glu Asn Lys Phe Lys Pro Phe Arg Val Glu 
            180                 185                 190         


Ile Val Asp Pro Val Asp Ile Tyr Leu Asn Leu Leu Arg Thr Ile Phe 
        195                 200                 205             


Asp Phe His Ala Ile Lys Gly Leu Leu Thr Gly Pro Ser Gln Leu Lys 
    210                 215                 220                 


Ile Arg Ile Asp Ala Met His Gly Val Met Gly Pro Tyr Val Arg Lys 
225                 230                 235                 240 


Val Leu Cys Asp Glu Leu Gly Ala Pro Ala Asn Ser Ala Ile Asn Cys 
                245                 250                 255     


Val Pro Leu Glu Asp Phe Gly Gly Gln His Pro Asp Pro Asn Leu Thr 
            260                 265                 270         


Tyr Ala Thr Thr Leu Leu Glu Ala Met Lys Gly Gly Glu Tyr Gly Phe 
        275                 280                 285             


Gly Ala Ala Phe Asp Ala Asp Gly Asp Arg Tyr Met Ile Leu Gly Gln 
    290                 295                 300                 


Asn Gly Phe Phe Val Ser Pro Ser Asp Ser Leu Ala Ile Ile Ala Ala 
305                 310                 315                 320 


Asn Leu Ser Cys Ile Pro Tyr Phe Arg Gln Met Gly Val Arg Gly Phe 
                325                 330                 335     


Gly Arg Ser Met Pro Thr Ser Met Ala Leu Asp Arg Val Ala Lys Ser 
            340                 345                 350         


Met Lys Val Pro Val Tyr Glu Thr Pro Ala Gly Trp Arg Phe Phe Ser 
        355                 360                 365             


Asn Leu Met Asp Ser Gly Arg Cys Asn Leu Cys Gly Glu Glu Ser Phe 
    370                 375                 380                 


Gly Thr Gly Ser Asp His Leu Arg Glu Lys Asp Gly Leu Trp Ala Val 
385                 390                 395                 400 


Leu Val Trp Leu Ser Ile Ile Ala Ala Arg Lys Gln Ser Val Glu Glu 
                405                 410                 415     


Ile Val Arg Asp His Trp Ala Lys Phe Gly Arg His Tyr Tyr Cys Arg 
            420                 425                 430         


Phe Asp Tyr Glu Gly Leu Asp Pro Lys Thr Thr Tyr Tyr Ile Met Arg 
        435                 440                 445             


Asp Leu Glu Ala Leu Val Thr Asp Lys Ser Phe Ile Gly Gln Gln Phe 
    450                 455                 460                 


Ala Val Gly Ser His Val Tyr Ser Val Ala Lys Thr Asp Ser Phe Glu 
465                 470                 475                 480 


Tyr Val Asp Pro Val Asp Gly Thr Val Thr Lys Lys Gln Gly Leu Arg 
                485                 490                 495     


Ile Ile Phe Ser Asp Ala Ser Arg Leu Ile Phe Arg Leu Ser Ser Ser 
            500                 505                 510         


Ser Gly Val Arg Ala Thr Leu Arg Leu Tyr Ala Glu Ser Tyr Glu Arg 
        515                 520                 525             


Asp Pro Ser Gly His Asp Gln Glu Pro Gln Ala Val Leu Ser Pro Leu 
    530                 535                 540                 


Ile Ala Ile Ala Leu Lys Ile Ser Gln Ile His Glu Arg Thr Gly Arg 
545                 550                 555                 560 


Arg Gly Pro Thr Val Ile Thr 
                565         


<210>  646
<211>  1516
<212>  DNA
<213>  Homo Sapiens

<400>  646
cacagcagct gtggctgggg agcccagatg aagtgtggct ctatcttgta tgtgagcaca       60

cccacatttt cactgccatt atctgggaca gcagaaccag gtttggctca acagatttct      120

ctttccaccc atctattgca ggtgtagtgg tcttgctgct tctccaggga ggatctgcct      180

acaaactggt ttgctacttt accaactggt cccaggaccg gcaggaacca ggaaaattca      240

cccctgagaa tattgacccc ttcctatgct ctcatctcat ctattcattc gccagcatcg      300

aaaacaacaa ggttatcatc aaggacaaga gtgaagtgat gctctaccag accatcaaca      360

gtctcaaaac caagaatccc aaactgaaaa ttctcttgtc cattggaggg tacctgtttg      420

gttccaaagg gttccaccct atggtggatt cttctacatc acgcttggaa ttcattaact      480

ccataatcct gtttctgagg aaccataact ttgatggact ggatgtaagc tggatctacc      540

cagatcagaa agaaaacact catttcactg tgctgattca tgagttagca gaagcctttc      600

agaaggactt cacaaaatcc accaaggaaa ggcttctctt gactgcgggc gtatctgcag      660

ggaggcaaat gattgataac agctatcaag ttgagaaact ggcaaaagat ctggatttca      720

tcaacctcct gtcctttgac ttccatgggt cttgggaaaa gccccttatc actggccaca      780

acagccctct gagcaagggg tggcaggaca gagggccaag ctcctactac aatgtggaat      840

atgctgtggg gtactggata cataagggaa tgccatcaga gaaggtggtc atgggcatcc      900

ccacatatgg gcactccttc acactggcct ctgcagaaac caccgtgggg gcccctgcct      960

ctggccctgg agctgctgga cccatcacag agtcttcagg cttcctggcc tattatgaga     1020

tctgccagtt cctgaaagga gccaagatca cgcggctcca ggatcagcag gttccctacg     1080

cagtcaaggg gaaccagtgg gtgggctatg atgatgtgaa gagtatggag accaaggttc     1140

agttcttaaa gaatttaaac ctgggaggag ccatgatctg gtctattgac atggatgact     1200

tcactggcaa atcctgcaac cagggccctt accctcttgt ccaagcagtc aagagaagcc     1260

ttggctccct gtgaaggatt aacttacaga gaagcaggca agatgacctt gctgcctggg     1320

gcctgctctc tcccaggaat tctcatgtgg gattcccctt gccaggctgg cctttggatc     1380

tctcttccaa gcctttcctg acttcctctt agatcataga ttggacctgg ttttgttttc     1440

ctgcagctgt tgacttgttg ccctgaagta caataaaaaa aattcatttt gctccagtaa     1500

aaaaaaaaaa aaaaaa                                                     1516


<210>  647
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  647

Met Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu 
1               5                   10                  15      


Lys Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe 
            20                  25                  30          


His Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser 
        35                  40                  45              


Ile Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser 
    50                  55                  60                  


Trp Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile 
65                  70                  75                  80  


His Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys 
                85                  90                  95      


Glu Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile 
            100                 105                 110         


Asp Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile 
        115                 120                 125             


Asn Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile 
    130                 135                 140                 


Thr Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro 
145                 150                 155                 160 


Ser Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys 
                165                 170                 175     


Gly Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His 
            180                 185                 190         


Ser Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser 
        195                 200                 205             


Gly Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala 
    210                 215                 220                 


Tyr Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu 
225                 230                 235                 240 


Gln Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly 
                245                 250                 255     


Tyr Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn 
            260                 265                 270         


Leu Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe 
        275                 280                 285             


Thr Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val 
    290                 295                 300                 


Lys Arg Ser Leu Gly Ser Leu 
305                 310     


<210>  648
<211>  1326
<212>  DNA
<213>  Homo Sapiens

<400>  648
tggacaaatt tgcgggctgg ggaccatgga agtggaggaa atctacaagc accaggaagt       60

caagatgcaa gcaccagcct tcagggacaa gaaacagggg gtctcagcca agaatcaagg      120

tgcccatgac ccagactatg agaatatcac cttggccttc aaaaatcagg accatgcaaa      180

gggtggtcat tcacgaccca cgagccaagt cccagcccag tgcaggccgc cctcagactc      240

cacccaggtc ccctgctggt tgtacagagc catcctgagc ctgtacatcc tcctggccct      300

ggcctttgtc ctctgcatca tcctgtcagc cttcatcatg gtgaagaatg ctgagatgtc      360

caaggagctg ctgggcttta aaagggagct ttggaatgtc tcaaactccg tacaagcatg      420

cgaagagaga cagaagagag gctgggattc cgttcagcag agcatcacca tggtcaggag      480

caagattgat agattagaga cgacattagc aggcataaaa aacattgaca caaaggtaca      540

gaaaatcttg gaggtgctgc agaaaatgcc acagtcctca cctcaataaa tgagaggaca      600

ttgtggcagc caaagccaca acttggaaga tggggctgca cctgccaacg aagacgggaa      660

atgacccccc ccccccagcc tagtgtgaac ctgcccctcg tcccacgtat agaaaaacct      720

cgagtcatgg tgaatgagtg tctcggagtt gctcgtgtgt gtgtacacct gcgtgcgtgt      780

gtgtgcgtgt gtgcgcgtgt gttcgtgtat gtgcgtgtgt gcgtgcgcgt gtgtgtgcat      840

tttgcaaagg gtggacattt cagtgtatct cccagaaagg tgatgaatga ataggactga      900

gagtcacagt gaatgtggca tgcatgcctg tgtcatgtga catatgtgag tctcggcatg      960

tcacggtggg tggctgtgtc tgagcacctc cagcagatgt cactctgagt gtgggtgttg     1020

gtgacatgca ttgcacgggc ctgtctccct gtttgtgtaa acatactaga gtatactgcg     1080

gcgtgttttc tgtctaccca tgtcatggtg ggggagattt atctccgtac atgtgggtgt     1140

cgccatgtgt gccctgtcac tatctgtggc tgggtgaacg gctgtgtcat tatgagtgtg     1200

ccgagttatg ccaccctgtg tgctcagggc acatgcacac agacatttat ctctgcactc     1260

acattttgtg acttatgaag ataaataaag tcaagggaaa acagcgtcaa aaaaaaaaaa     1320

aaaaaa                                                                1326


<210>  649
<211>  187
<212>  PRT
<213>  Homo Sapiens

<400>  649

Met Glu Val Glu Glu Ile Tyr Lys His Gln Glu Val Lys Met Gln Ala 
1               5                   10                  15      


Pro Ala Phe Arg Asp Lys Lys Gln Gly Val Ser Ala Lys Asn Gln Gly 
            20                  25                  30          


Ala His Asp Pro Asp Tyr Glu Asn Ile Thr Leu Ala Phe Lys Asn Gln 
        35                  40                  45              


Asp His Ala Lys Gly Gly His Ser Arg Pro Thr Ser Gln Val Pro Ala 
    50                  55                  60                  


Gln Cys Arg Pro Pro Ser Asp Ser Thr Gln Val Pro Cys Trp Leu Tyr 
65                  70                  75                  80  


Arg Ala Ile Leu Ser Leu Tyr Ile Leu Leu Ala Leu Ala Phe Val Leu 
                85                  90                  95      


Cys Ile Ile Leu Ser Ala Phe Ile Met Val Lys Asn Ala Glu Met Ser 
            100                 105                 110         


Lys Glu Leu Leu Gly Phe Lys Arg Glu Leu Trp Asn Val Ser Asn Ser 
        115                 120                 125             


Val Gln Ala Cys Glu Glu Arg Gln Lys Arg Gly Trp Asp Ser Val Gln 
    130                 135                 140                 


Gln Ser Ile Thr Met Val Arg Ser Lys Ile Asp Arg Leu Glu Thr Thr 
145                 150                 155                 160 


Leu Ala Gly Ile Lys Asn Ile Asp Thr Lys Val Gln Lys Ile Leu Glu 
                165                 170                 175     


Val Leu Gln Lys Met Pro Gln Ser Ser Pro Gln 
            180                 185         


<210>  650
<211>  4815
<212>  DNA
<213>  Homo Sapiens

<400>  650
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt     1500

ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga     1560

tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt     1620

tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca     1680

gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac     1740

tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag     1800

cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg     1860

gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac     1920

tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct     1980

tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac     2040

cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga     2100

ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac     2160

caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca     2220

gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc     2280

tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga     2340

gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaagg     2400

aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg     2460

gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc     2520

ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga     2580

tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg     2640

ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta     2700

tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg     2760

cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag     2820

aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa     2880

aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct     2940

aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc     3000

actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa     3060

ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac     3120

ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt     3180

ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt     3240

ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca     3300

gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta     3360

gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg     3420

tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg     3480

gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc     3540

cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg     3600

atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt     3660

tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg     3720

cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct     3780

gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa     3840

gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt     3900

tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct     3960

ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag     4020

tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat     4080

agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg     4140

gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg     4200

tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct     4260

gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga     4320

tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa     4380

aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct     4440

aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt     4500

taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact     4560

gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg     4620

atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt     4680

ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga     4740

aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca     4800

attttgttaa accat                                                      4815


<210>  651
<211>  882
<212>  PRT
<213>  Homo Sapiens

<400>  651

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  652
<211>  2935
<212>  DNA
<213>  Homo Sapiens

<400>  652
ggagctggcg ctgggagggg aggagcgcgc agcccgcgcg ccgcagggcc gggcggaaag       60

tttttcctga cggagttttg gctgcggcag cggcggcggc ggccggagcg ggccatggac      120

gcgctcaagt cggcggggcg ggcgctgatc cggagcccca gcttggccaa gcagagctgg      180

gggggcggtg gccggcaccg caagctgcct gagaactgga cagacacgcg ggagacgctg      240

ctggagggga tgctgttcag cctcaagtac ctgggcatga cgctagtgga gcagcccaag      300

ggtgaggagc tgtcggccgc cgccatcaag aggatcgtgg ctacagctaa ggccagtggg      360

aagaagctgc agaaggtgac tctgaaggtg tcgccacggg gaattatcct gacagacaac      420

ctcaccaacc agctcattga gaacgtgtcc atatacagga tctcctattg cacagcagac      480

aagatgcacg acaaggtgtt tgcatacatc gcccagagcc agcacaacca gagcctcgag      540

tgccacgcct tcctctgcac caagcggaag atggcacagg ctgttaccct caccgtagcc      600

caggccttca aagtcgcctt tgagttttgg caggtgtcca aggaagagaa agagaagagg      660

gacaaagcca gccaagaggg aggggacgtc ctgggggccc gccaagactg caccccctcc      720

ttgaagagct tggtcgccac tgggaacctg ctggacttag aggagacagc taaggccccg      780

ctgtccacgg tcagcgccaa caccaccaac atggacgagg tgccgcggcc acaagccttg      840

agtggcagca gtgttgtctg ggagctggat gatggcctgg atgaagcgtt ttcgaggctt      900

gcccagtctc ggacaaaccc tcaggtcctg gacactggcc tgacagccca ggacatgcat      960

tacgcccagt gcctctcgcc tgtcgactgg gacaagcctg acagcagcgg cacagagcag     1020

gatgacctct tcagcttctg agggcccggg gccagccgga cacaagcggc cctgacacgt     1080

gatggaccaa agccacctgc tgcgggggag ccagttctgg ggcccgcctg ccacctctcc     1140

cagccctcag cattgtcagc ctgaagatca gagctgcagc cagtcaggca ggggagagat     1200

ttttctttta agccctgctc tttctctgag aaccaaaaga tgccttgaat atttattcag     1260

tgacttctgg cttatgctca gaagccagtc tgcgtcaggc acgtctcctg ctgcgtgaca     1320

tgtgcagtgc tgtaatcggc tcccgcttgc tctcctggag caagctctgc cctggctgtg     1380

ggtatcagga ctgtgaccaa agcatttcta gtcccttctc tctttctaag gacccaaatt     1440

tccctggggg catcctgctt cctgaaagct gttggatttc agtgattttt ccccccaccc     1500

cccagcacag gagagcaccc acagccgcag aaggggaatg tgtcctcctg ctctgcttcc     1560

tcagggccca gcaggcgggg gtttgagccc tggaccccag gctcttagag actaaggggc     1620

agctcctgac caaagacgat acagcttggc actttaaagc attaacagca ggtgtgaccc     1680

tgagggctcc tccatggtgc tgcattgagt ccagctttcc ttctgccctt cctccaggag     1740

aaggggccca aggtccccgt ggatggtctc cacctgtgct tggaaccagt gtaactggct     1800

gctccctgct cccagggact gacacgggga tcatctctgt gaccgccctc cgtcgggccc     1860

ctgcctgcct tctcccctcc acgcaaggct gtgctcttcc tctggtttct gtgtgtccgt     1920

ttgagtgtct gcgccccgcc tccccatact tcctgggatg atgtgtgaaa cctgacacct     1980

agatttattt ggaaatattc tatgaccact ttacagatga ggaaacaggc ctcaagcgtg     2040

gaggggtaga gtgaagagta gaacccaggt ctgatgccaa agctgctttc ttctctgcct     2100

cctcctcacg caactcacac ctccttttct tctagctttg ttgtcctccc aggaaccaaa     2160

aaaccccagc tattttctga ccaaaatgtg tttcataaca aaccatctgg tgcctttcca     2220

cacagaactg gcaggagcct cgtgtcctgc tagctgtctc tcttgttgat ttccgtgaaa     2280

atgcaagtgt ttgaagtctg ctcattccga gggtgaaaca aaatccaacc ctgtcagaat     2340

catgctgttc tctttgctga cactgtgacc ctgggtcggg acagaccagc agcaatctgt     2400

ctttagaatc gctttccttc ctcccctttt gcccccgtgg ggctcccggc atcctgaaag     2460

ccagcaaagc ctccagcatc ttttccatcc tgaggtgcct cccagtggcc tggcttgtcg     2520

gagcaagttt catcagccct agggaaaaca cggccctcct gggaacctcc ttacctggag     2580

taaccggaca ccttagacgg aggtgcctga gggtggggtg ggatttgcag ggtcattatc     2640

agaacatgag gataacttcc ttgcccctgc tctgtagcca cctccttggc accggcctct     2700

atttgtcata aggcggcgtg ggcgaggcct gacacaggcc agccttggca cgaggggggc     2760

caggggttct gagaagcgct gccctgtgag agccacgctg gccttcgtct ccatctctgg     2820

ttgacgggct gtccgtgtgc ctcctgtgtg tctgcagaca agtcttgctg tgctttattt     2880

gtgaaacttt aatgaggaaa aaacaaataa taaatgttct cgttttgaaa ctcaa          2935


<210>  653
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  653

Met Asp Ala Leu Lys Ser Ala Gly Arg Ala Leu Ile Arg Ser Pro Ser 
1               5                   10                  15      


Leu Ala Lys Gln Ser Trp Gly Gly Gly Gly Arg His Arg Lys Leu Pro 
            20                  25                  30          


Glu Asn Trp Thr Asp Thr Arg Glu Thr Leu Leu Glu Gly Met Leu Phe 
        35                  40                  45              


Ser Leu Lys Tyr Leu Gly Met Thr Leu Val Glu Gln Pro Lys Gly Glu 
    50                  55                  60                  


Glu Leu Ser Ala Ala Ala Ile Lys Arg Ile Val Ala Thr Ala Lys Ala 
65                  70                  75                  80  


Ser Gly Lys Lys Leu Gln Lys Val Thr Leu Lys Val Ser Pro Arg Gly 
                85                  90                  95      


Ile Ile Leu Thr Asp Asn Leu Thr Asn Gln Leu Ile Glu Asn Val Ser 
            100                 105                 110         


Ile Tyr Arg Ile Ser Tyr Cys Thr Ala Asp Lys Met His Asp Lys Val 
        115                 120                 125             


Phe Ala Tyr Ile Ala Gln Ser Gln His Asn Gln Ser Leu Glu Cys His 
    130                 135                 140                 


Ala Phe Leu Cys Thr Lys Arg Lys Met Ala Gln Ala Val Thr Leu Thr 
145                 150                 155                 160 


Val Ala Gln Ala Phe Lys Val Ala Phe Glu Phe Trp Gln Val Ser Lys 
                165                 170                 175     


Glu Glu Lys Glu Lys Arg Asp Lys Ala Ser Gln Glu Gly Gly Asp Val 
            180                 185                 190         


Leu Gly Ala Arg Gln Asp Cys Thr Pro Ser Leu Lys Ser Leu Val Ala 
        195                 200                 205             


Thr Gly Asn Leu Leu Asp Leu Glu Glu Thr Ala Lys Ala Pro Leu Ser 
    210                 215                 220                 


Thr Val Ser Ala Asn Thr Thr Asn Met Asp Glu Val Pro Arg Pro Gln 
225                 230                 235                 240 


Ala Leu Ser Gly Ser Ser Val Val Trp Glu Leu Asp Asp Gly Leu Asp 
                245                 250                 255     


Glu Ala Phe Ser Arg Leu Ala Gln Ser Arg Thr Asn Pro Gln Val Leu 
            260                 265                 270         


Asp Thr Gly Leu Thr Ala Gln Asp Met His Tyr Ala Gln Cys Leu Ser 
        275                 280                 285             


Pro Val Asp Trp Asp Lys Pro Asp Ser Ser Gly Thr Glu Gln Asp Asp 
    290                 295                 300                 


Leu Phe Ser Phe 
305             


<210>  654
<211>  2782
<212>  DNA
<213>  Homo Sapiens

<400>  654
gggcggcgcg gaggggcagg gccagaggga agcgctttgt tccgcgcgtg gttcccgcgc       60

ctgggggtgc gcgggagagg cgcgaatccg agtgccgcgc gcggcccggg gacttgcacg      120

ggcgtgcggg gtggaaccgc aggaagcgga gctctcgggt tcccgccccg ccccgccccg      180

ccggcggcgg aggcagcgag cgcgagagcc cagcggagtc gctgggagcc tgaggcaccg      240

agacacaaag gcaggcggga tgcgggagca ggcaaaggga aagcgaaagc cgcgcgcccg      300

gccggtgact gggtgaaggc gccgcgcagc tttcccgacg ccggctgtac ccggacctcc      360

tggtcgagcc tggcgcgccg cagccatggc catcgctcaa ctggccacgg agtacgtgtt      420

ctcggatttc ttgctgaagg agcccacgga gcccaagttc aaggggctgc gactggagct      480

ggctgtggac aagatggtca cgtgcattgc ggtggggctg cccctgctgc tcatctcgct      540

ggccttcgcg caggagatct cgattggtac acagataagc tgtttctctc caagttcttt      600

ctcctggcgt caggctgcct ttgtggattc atattgctgg gcggctgttc agcagaagaa      660

ctcactgcag agcgagtctg gaaacctccc actgtggctg cataagtttt tcccctacat      720

cctgctgctc tttgcgatcc tcctgtacct gcccccgctg ttctggcgtt tcgcagctgc      780

tcctcatatt tgctcagact tgaagtttat catggaagaa cttgacaaag tttacaaccg      840

tgcaattaag gctgcaaaga gtgcgcgtga ccttgacatg agagatggag cctgctcagt      900

tccaggtgtt accgagaact tagggcaaag tttgtgggag gtatctgaaa gccacttcaa      960

gtacccaatt gtggagcagt acttgaagac aaagaaaaat tctaataatt taatcatcaa     1020

gtacattagc tgccgcctgc tgacactcat cattatactg ttagcgtgta tctacctggg     1080

ctattacttc agcctctcct cactctcaga cgagtttgtg tgcagcatca aatcagggat     1140

cctgagaaac gacagcaccg tgcccgatca gtttcagtgc aaactcattg ccgtgggcat     1200

cttccagttg ctcagtgtca ttaaccttgt ggtttatgtc ctgctggctc ccgtggttgt     1260

ctacacgctg tttgttccat tccgacagaa gacagatgtt ctcaaagtgt acgaaatcct     1320

ccccactttt gatgttctgc atttcaaatc tgaagggtac aacgatttga gcctctacaa     1380

tctcttcttg gaggaaaata taagtgaggt caagtcatac aagtgtctta aggtactgga     1440

gaatattaag agcagtggtc aggggatcga cccaatgcta ctcctgacaa accttggcat     1500

gatcaagatg gatgttgttg atggcaaaac tcccatgtct gcagagatga gagaggagca     1560

ggggaaccag acggcagagc tccaaggtat gaacatagac agtgaaacta aagcaaataa     1620

tggagagaag aatgcccgac agagacttct ggattcttct tgctgatgat ttttttcctt     1680

gagctgtaaa tctgtgactt ctgcgacatg ggatttaatt tggctaaagc acccctgttg     1740

gtttcacagc tggtttgcaa taaatggttc ttggtggaga tactgagcat gtcttattga     1800

gtccctaatg gaaatggtga tcaacaaaag gttatggaag aatggtttat gaacttccca     1860

taggaagcac ctgagagata gtaaactgca gcaagtaact atgtgtaagt cctcatcaaa     1920

tgaaaagcag aaagacaaga acaattagtc aagagcagta gccctgtcag agcctcggag     1980

caataccttt ctgtacccgt ggtgagacaa gacccagagc tactggaaaa caagcacttt     2040

ggaagatttg ttttgttttc atggaataat aatatgtcag ggtataattt aacgtgagtt     2100

tcttatgtgc ccttaaagac tgttagacaa gaaaagcatt cactggctaa taatccatag     2160

gtcgacctat gtcctaagtt aggtgtaagg tccgatgcct tggcccacac tcgagctctc     2220

tttacattgt tagttgtcaa ccttggctga tggaaatccc gtaaccacta tttgttgcac     2280

tgtgccttga agggcagcag gcccaagtgc tgctctgact gaaaactgag ttaacaagat     2340

gaaatctaaa ggatattcac agtgacttca attcaggaag aatgcttcca aaagagccca     2400

gtggggaaat ctgacatcac agaagacatt aattcagtca ctttcaaaga gtttgtctac     2460

aggcggtttc tctgttatca aaggcatttg aaataggatt ttacttaaac aataatggaa     2520

cacaggagta tttaaagtga agaacacttt gcctgaatgt gatcagggca cataagtgac     2580

attggcatgc ttcatatggc gtgcttggag ccagaaaaac ttagcggttt attttgttta     2640

tatttaagca cagctttaaa aaattcatta tcgtttattc agtgtccgaa ttgaggccat     2700

ttgggaagaa aattctagca ctggtggaga attatagaat aaagattata aatggttgga     2760

taagacaaaa aaaaaaaaaa aa                                              2782


<210>  655
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  655

Met Ala Ile Ala Gln Leu Ala Thr Glu Tyr Val Phe Ser Asp Phe Leu 
1               5                   10                  15      


Leu Lys Glu Pro Thr Glu Pro Lys Phe Lys Gly Leu Arg Leu Glu Leu 
            20                  25                  30          


Ala Val Asp Lys Met Val Thr Cys Ile Ala Val Gly Leu Pro Leu Leu 
        35                  40                  45              


Leu Ile Ser Leu Ala Phe Ala Gln Glu Ile Ser Ile Gly Thr Gln Ile 
    50                  55                  60                  


Ser Cys Phe Ser Pro Ser Ser Phe Ser Trp Arg Gln Ala Ala Phe Val 
65                  70                  75                  80  


Asp Ser Tyr Cys Trp Ala Ala Val Gln Gln Lys Asn Ser Leu Gln Ser 
                85                  90                  95      


Glu Ser Gly Asn Leu Pro Leu Trp Leu His Lys Phe Phe Pro Tyr Ile 
            100                 105                 110         


Leu Leu Leu Phe Ala Ile Leu Leu Tyr Leu Pro Pro Leu Phe Trp Arg 
        115                 120                 125             


Phe Ala Ala Ala Pro His Ile Cys Ser Asp Leu Lys Phe Ile Met Glu 
    130                 135                 140                 


Glu Leu Asp Lys Val Tyr Asn Arg Ala Ile Lys Ala Ala Lys Ser Ala 
145                 150                 155                 160 


Arg Asp Leu Asp Met Arg Asp Gly Ala Cys Ser Val Pro Gly Val Thr 
                165                 170                 175     


Glu Asn Leu Gly Gln Ser Leu Trp Glu Val Ser Glu Ser His Phe Lys 
            180                 185                 190         


Tyr Pro Ile Val Glu Gln Tyr Leu Lys Thr Lys Lys Asn Ser Asn Asn 
        195                 200                 205             


Leu Ile Ile Lys Tyr Ile Ser Cys Arg Leu Leu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Leu Leu Ala Cys Ile Tyr Leu Gly Tyr Tyr Phe Ser Leu Ser Ser Leu 
225                 230                 235                 240 


Ser Asp Glu Phe Val Cys Ser Ile Lys Ser Gly Ile Leu Arg Asn Asp 
                245                 250                 255     


Ser Thr Val Pro Asp Gln Phe Gln Cys Lys Leu Ile Ala Val Gly Ile 
            260                 265                 270         


Phe Gln Leu Leu Ser Val Ile Asn Leu Val Val Tyr Val Leu Leu Ala 
        275                 280                 285             


Pro Val Val Val Tyr Thr Leu Phe Val Pro Phe Arg Gln Lys Thr Asp 
    290                 295                 300                 


Val Leu Lys Val Tyr Glu Ile Leu Pro Thr Phe Asp Val Leu His Phe 
305                 310                 315                 320 


Lys Ser Glu Gly Tyr Asn Asp Leu Ser Leu Tyr Asn Leu Phe Leu Glu 
                325                 330                 335     


Glu Asn Ile Ser Glu Val Lys Ser Tyr Lys Cys Leu Lys Val Leu Glu 
            340                 345                 350         


Asn Ile Lys Ser Ser Gly Gln Gly Ile Asp Pro Met Leu Leu Leu Thr 
        355                 360                 365             


Asn Leu Gly Met Ile Lys Met Asp Val Val Asp Gly Lys Thr Pro Met 
    370                 375                 380                 


Ser Ala Glu Met Arg Glu Glu Gln Gly Asn Gln Thr Ala Glu Leu Gln 
385                 390                 395                 400 


Gly Met Asn Ile Asp Ser Glu Thr Lys Ala Asn Asn Gly Glu Lys Asn 
                405                 410                 415     


Ala Arg Gln Arg Leu Leu Asp Ser Ser Cys 
            420                 425     


<210>  656
<211>  2782
<212>  DNA
<213>  Homo Sapiens

<400>  656
gggcggcgcg gaggggcagg gccagaggga agcgctttgt tccgcgcgtg gttcccgcgc       60

ctgggggtgc gcgggagagg cgcgaatccg agtgccgcgc gcggcccggg gacttgcacg      120

ggcgtgcggg gtggaaccgc aggaagcgga gctctcgggt tcccgccccg ccccgccccg      180

ccggcggcgg aggcagcgag cgcgagagcc cagcggagtc gctgggagcc tgaggcaccg      240

agacacaaag gcaggcggga tgcgggagca ggcaaaggga aagcgaaagc cgcgcgcccg      300

gccggtgact gggtgaaggc gccgcgcagc tttcccgacg ccggctgtac ccggacctcc      360

tggtcgagcc tggcgcgccg cagccatggc catcgctcaa ctggccacgg agtacgtgtt      420

ctcggatttc ttgctgaagg agcccacgga gcccaagttc aaggggctgc gactggagct      480

ggctgtggac aagatggtca cgtgcattgc ggtggggctg cccctgctgc tcatctcgct      540

ggccttcgcg caggagatct cgattggtac acagataagc tgtttctctc caagttcttt      600

ctcctggcgt caggctgcct ttgtggattc atattgctgg gcggctgttc agcagaagaa      660

ctcactgcag agcgagtctg gaaacctccc actgtggctg cataagtttt tcccctacat      720

cctgctgctc tttgcgatcc tcctgtacct gcccccgctg ttctggcgtt tcgcagctgc      780

tcctcatatt tgctcagact tgaagtttat catggaagaa cttgacaaag tttacaaccg      840

tgcaattaag gctgcaaaga gtgcgcgtga ccttgacatg agagatggag cctgctcagt      900

tccaggtgtt accgagaact tagggcaaag tttgtgggag gtatctgaaa gccacttcaa      960

gtacccaatt gtggagcagt acttgaagac aaagaaaaat tctaataatt taatcatcaa     1020

gtacattagc tgccgcctgc tgacactcat cattatactg ttagcgtgta tctacctggg     1080

ctattacttc agcctctcct cactctcaga cgagtttgtg tgcagcatca aatcagggat     1140

cctgagaaac gacagcaccg tgcccgatca gtttcagtgc aaactcattg ccgtgggcat     1200

cttccagttg ctcagtgtca ttaaccttgt ggtttatgtc ctgctggctc ccgtggttgt     1260

ctacacgctg tttgttccat tccgacagaa gacagatgtt ctcaaagtgt acgaaatcct     1320

ccccactttt gatgttctgc atttcaaatc tgaagggtac aacgatttga gcctctacaa     1380

tctcttcttg gaggaaaata taagtgaggt caagtcatac aagtgtctta aggtactgga     1440

gaatattaag agcagtggtc aggggatcga cccaatgcta ctcctgacaa accttggcat     1500

gatcaagatg gatgttgttg atggcaaaac tcccatgtct gcagagatga gagaggagca     1560

ggggaaccag acggcagagc tccaaggtat gaacatagac agtgaaacta aagcaaataa     1620

tggagagaag aatgcccgac agagacttct ggattcttct tgctgatgat ttttttcctt     1680

gagctgtaaa tctgtgactt ctgcgacatg ggatttaatt tggctaaagc acccctgttg     1740

gtttcacagc tggtttgcaa taaatggttc ttggtggaga tactgagcat gtcttattga     1800

gtccctaatg gaaatggtga tcaacaaaag gttatggaag aatggtttat gaacttccca     1860

taggaagcac ctgagagata gtaaactgca gcaagtaact atgtgtaagt cctcatcaaa     1920

tgaaaagcag aaagacaaga acaattagtc aagagcagta gccctgtcag agcctcggag     1980

caataccttt ctgtacccgt ggtgagacaa gacccagagc tactggaaaa caagcacttt     2040

ggaagatttg ttttgttttc atggaataat aatatgtcag ggtataattt aacgtgagtt     2100

tcttatgtgc ccttaaagac tgttagacaa gaaaagcatt cactggctaa taatccatag     2160

gtcgacctat gtcctaagtt aggtgtaagg tccgatgcct tggcccacac tcgagctctc     2220

tttacattgt tagttgtcaa ccttggctga tggaaatccc gtaaccacta tttgttgcac     2280

tgtgccttga agggcagcag gcccaagtgc tgctctgact gaaaactgag ttaacaagat     2340

gaaatctaaa ggatattcac agtgacttca attcaggaag aatgcttcca aaagagccca     2400

gtggggaaat ctgacatcac agaagacatt aattcagtca ctttcaaaga gtttgtctac     2460

aggcggtttc tctgttatca aaggcatttg aaataggatt ttacttaaac aataatggaa     2520

cacaggagta tttaaagtga agaacacttt gcctgaatgt gatcagggca cataagtgac     2580

attggcatgc ttcatatggc gtgcttggag ccagaaaaac ttagcggttt attttgttta     2640

tatttaagca cagctttaaa aaattcatta tcgtttattc agtgtccgaa ttgaggccat     2700

ttgggaagaa aattctagca ctggtggaga attatagaat aaagattata aatggttgga     2760

taagacaaaa aaaaaaaaaa aa                                              2782


<210>  657
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  657

Met Ala Ile Ala Gln Leu Ala Thr Glu Tyr Val Phe Ser Asp Phe Leu 
1               5                   10                  15      


Leu Lys Glu Pro Thr Glu Pro Lys Phe Lys Gly Leu Arg Leu Glu Leu 
            20                  25                  30          


Ala Val Asp Lys Met Val Thr Cys Ile Ala Val Gly Leu Pro Leu Leu 
        35                  40                  45              


Leu Ile Ser Leu Ala Phe Ala Gln Glu Ile Ser Ile Gly Thr Gln Ile 
    50                  55                  60                  


Ser Cys Phe Ser Pro Ser Ser Phe Ser Trp Arg Gln Ala Ala Phe Val 
65                  70                  75                  80  


Asp Ser Tyr Cys Trp Ala Ala Val Gln Gln Lys Asn Ser Leu Gln Ser 
                85                  90                  95      


Glu Ser Gly Asn Leu Pro Leu Trp Leu His Lys Phe Phe Pro Tyr Ile 
            100                 105                 110         


Leu Leu Leu Phe Ala Ile Leu Leu Tyr Leu Pro Pro Leu Phe Trp Arg 
        115                 120                 125             


Phe Ala Ala Ala Pro His Ile Cys Ser Asp Leu Lys Phe Ile Met Glu 
    130                 135                 140                 


Glu Leu Asp Lys Val Tyr Asn Arg Ala Ile Lys Ala Ala Lys Ser Ala 
145                 150                 155                 160 


Arg Asp Leu Asp Met Arg Asp Gly Ala Cys Ser Val Pro Gly Val Thr 
                165                 170                 175     


Glu Asn Leu Gly Gln Ser Leu Trp Glu Val Ser Glu Ser His Phe Lys 
            180                 185                 190         


Tyr Pro Ile Val Glu Gln Tyr Leu Lys Thr Lys Lys Asn Ser Asn Asn 
        195                 200                 205             


Leu Ile Ile Lys Tyr Ile Ser Cys Arg Leu Leu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Leu Leu Ala Cys Ile Tyr Leu Gly Tyr Tyr Phe Ser Leu Ser Ser Leu 
225                 230                 235                 240 


Ser Asp Glu Phe Val Cys Ser Ile Lys Ser Gly Ile Leu Arg Asn Asp 
                245                 250                 255     


Ser Thr Val Pro Asp Gln Phe Gln Cys Lys Leu Ile Ala Val Gly Ile 
            260                 265                 270         


Phe Gln Leu Leu Ser Val Ile Asn Leu Val Val Tyr Val Leu Leu Ala 
        275                 280                 285             


Pro Val Val Val Tyr Thr Leu Phe Val Pro Phe Arg Gln Lys Thr Asp 
    290                 295                 300                 


Val Leu Lys Val Tyr Glu Ile Leu Pro Thr Phe Asp Val Leu His Phe 
305                 310                 315                 320 


Lys Ser Glu Gly Tyr Asn Asp Leu Ser Leu Tyr Asn Leu Phe Leu Glu 
                325                 330                 335     


Glu Asn Ile Ser Glu Val Lys Ser Tyr Lys Cys Leu Lys Val Leu Glu 
            340                 345                 350         


Asn Ile Lys Ser Ser Gly Gln Gly Ile Asp Pro Met Leu Leu Leu Thr 
        355                 360                 365             


Asn Leu Gly Met Ile Lys Met Asp Val Val Asp Gly Lys Thr Pro Met 
    370                 375                 380                 


Ser Ala Glu Met Arg Glu Glu Gln Gly Asn Gln Thr Ala Glu Leu Gln 
385                 390                 395                 400 


Gly Met Asn Ile Asp Ser Glu Thr Lys Ala Asn Asn Gly Glu Lys Asn 
                405                 410                 415     


Ala Arg Gln Arg Leu Leu Asp Ser Ser Cys 
            420                 425     


<210>  658
<211>  5370
<212>  DNA
<213>  Homo Sapiens

<400>  658
cgcatgcgct ggcggcctgc gccgccttaa gtgccgcgcc agcccggggc ggcccagtcg       60

gcctgtcagc cggcttcgag ataagtcccg gcgcttgcgc ggcggcggct atggcggcgg      120

aggaggagga ggtggactct gccgacaccg gagagaggtc aggatggcta actggttggc      180

tccccacatg gtgccctacg tctatatcac accttaaaga agctgaagag aagatgttaa      240

aatgtgtgcc ttgcacatac aaaaaagaac ctgttcgtat atctaatgga aataaaatat      300

ggacactgaa gttctctcat aatatttcaa ataagactcc acttgtcctt ctccatggtt      360

ttggaggagg tcttgggctc tgggcactga attttggaga tctttgcacc aacagacctg      420

tctatgcttt tgacctattg ggttttggac gaagtagtag acccaggttt gacagtgatg      480

cagaagaagt ggagaatcag tttgtggaat ccattgaaga gtggagatgt gccctaggat      540

tggacaaaat gatcttgctt gggcacaacc taggtggatt cttggctgct gcttactcgc      600

tgaagtaccc atcaagggtt aatcatctca ttttagtgga gccttggggt ttccctgaac      660

gaccagacct tgctgatcaa gacagaccaa ttccagtttg gatcagagcc ttgggagcag      720

cattgactcc ctttaaccct ttagctggcc taaggattgc aggacccttt ggtttaagtc      780

tagtgcagcg tttaaggcct gatttcaaac gaaagtattc ttcaatgttc gaagacgata      840

ctgtgacaga atacatctac cactgtaatg tgcagactcc aagtggtgag acagctttca      900

agaatatgac tattccttat ggatgggcaa aaaggccaat gctccagcga attggtaaaa      960

tgcaccctga cattccagtt tcagtgatct ttggcgcccg atcctgcata gatggcaatt     1020

ctggcaccag catccagtcc ttacgaccac attcatatgt gaagacaata gctattcttg     1080

gggcaggaca ttatgtatat gcagatcaac cagaagaatt caaccagaaa gtaaaggaga     1140

tctgcgacac tgtggactga acacactgaa gctctgatgg gaaaacctgg tgactgatat     1200

agttgttcag caataattca tagtctgtga tgaagagtag tgaatacaac acacaaccag     1260

gcagccttct tgactatact ttgcacatgt tttctttagg aattcactca cacatttaaa     1320

ccagttagtg ccttctagaa gaatggcttt cctttctcct acacaaaatt gaaatataca     1380

agtctctaaa tataatacct ttaaataaaa ggttatttgt ccctctgatg tactgaaaaa     1440

ctgtaatttt tcagctgaaa attttttaat ctaactttgc tagttatttt tatattgcaa     1500

tctatattac caatttagga agtgatttct gagtctctta cactgtaaag gtgcacttta     1560

ttttctttgt cttccccatc atgtatttat tgtgtcttga taactgatat taatctaaat     1620

tcaatgtgtt tttatgtaaa aatttgtcag ttgtttagaa tatttcactt tgtttttgaa     1680

acggagtgac aaggcagatt tttggttaga ggacgggagt tgatcactat cattactttt     1740

tctagtttac ctgtttttta tatttaaggc tgctaagcca tgttcagcat tttaaatgtg     1800

gtctatcctg acatacagtg tataacaaca taactccttg gaacctccta tgtgtggtat     1860

aattctactc ttccaaggaa catgacttca atactttcag tgattcaggt actgaaaagc     1920

cttacctaaa aggctgttct ttgtttcccc ctttcatact attcttttcc atgacccagg     1980

atgcagcaaa tgaaacagat ttcttctctt aaggggatat taagactgtt acttcctagt     2040

aagccaagta ataccatatt tttattaaca tctaactttt gtagatgggt gctaaaattg     2100

catacatttt aaccactaaa atagaaaaac aagtggtgct attatgtctc atggcaccag     2160

aaatgagcta gcacttgggt ttgttgttgc tgttgtttat taagagtatt gtgttaatta     2220

aatcattaca tacttgaagt tatattacaa aaattctaga aggttgattg aactattttt     2280

ttaggaacta ccatcaagtg tagcattttc ttgcagtttt aaaatgagga aaacttcttt     2340

gaaactgtga aatgctccat gtggtaactg gctgctgaga aaacccttca ccaaaaaaat     2400

aaataaaaat tgaataggat tgtcatcaag aaggcatctt tcgctaacgt tgcttgtcta     2460

ggagaaaggt agctatgtaa ataaaaacag tgaactagag caaatagtgg tttaatggtt     2520

ttgttattgc atttttaaaa tggttaatta gggaatttgt agttgttagg aaatgtaagg     2580

ttgtgtcact gttgattaac tgccagaaag actgaatgtt ctattttcaa catttctccc     2640

ctataaaaga atagacaaat tatactgaag catgatataa acatcttccc aatgaacaat     2700

ttgtctcact tgtcagatta actaggttag tgcaggaagc aacatgagcg ccaagatgtg     2760

ttgtctgatt tctctacctt aagaacaata atagtctttt tagttagtat tttggatggc     2820

caggtttcaa acctgtatgt ggtacaaata atttgggtaa tatttttgta tttttgtttt     2880

acacactctc taatctcaat tatcctttgc tgggagaatg acaggtttca cttatacagg     2940

aaggtttttg cacaggaaat ttggtcccag cccttggaag gaagaagttc cttcgtttac     3000

ttagtgaatg gagtttctgg ccgcagatgt gccaagtgat tgaagaaaga tataccccaa     3060

tatcaagtga taatttattt tcctacagac tgaatttgct ttatttgaaa gatgttgtaa     3120

ctctttttaa agttagattt taccctgagg tatagtatat gtaattttgt gaagattgag     3180

ctggaaggga agttcacaat cctcacattt aaaaaaatat agtgggtgct aaatgttttc     3240

ttaaaaatct agtacagcat ttgatctttg ttatgcacag catactttta ttttacagaa     3300

taaattttcc tgtgatagtc acaacaagac agctgtatag tttcttgagt cttttgtatg     3360

gaccagtctc tgtataatag ttaactacag gactgtggat ccagcaaatg ttcagtaaat     3420

gctgctgttg ttcttaggga aggctactct gggtgttgtg gccgccatac atggctttac     3480

ctgggtccat gcattccctt aagatgactt ctgttttctt cttttttctt ctgattttcc     3540

aaaaaaaaaa aagccttgcc taaggttggt tttagaatat gatttgcaga acacttttga     3600

aatgtcttca ttcatatatg taatatatat ttatacttaa agggccatac gcgatttcaa     3660

taaaacaaga agtactggaa agaataaaca aaaatagcca gaagatgcct agaaaagaac     3720

aatgtggaag gagggataac cctattaaat attataacat aatgtttaca atatgagaaa     3780

gtctaggaat ttagtacatg ataaagcatc tcattcagag aaaaaggctt taaaaatggt     3840

gttgagagaa gtgtggttaa ccatttggaa aaaaaaataa aattgaatcg atttctcaca     3900

ggatacacag gataaaatct gaatagaaca aagacccaat ttttaaaatg aaaccctctt     3960

tctaactaga agaaaacata gatgaattat tgtataatct gacagtgaga aaaactttcc     4020

taggactgaa aattcagaag caataaaaag agaagtctat agaagaattt tcagccagat     4080

ggaatggctc atggctgtaa tcccagcatt ttgggaggct gaggcagaag gactgcttga     4140

gaccaggaat tcaaaaccaa cctgggcaac ctagtaggac tggctctacc aaaaaaaaaa     4200

aaaaaaaaaa attaagtacc tggcctgggt tccacctact tgggaggctg aggtaggagg     4260

actgtgagcc caggagtttg aggatgcagt aagccactgc actccagcct gggtgacaga     4320

gaagaaaaaa gatttttttg gatagctgaa aatatttgca gcatttatca cagagggcta     4380

attgtagccc tatatatgaa gaattttaaa ctatgagaag aacccgaaga ataggcaaaa     4440

ggatgtgaac agacagttaa cagaaaatag aatgcaaatg gtctttaaac atacaaggat     4500

atgcataaaa agacaaatgc aaaataaaat aaaataatgg aaataccttt cttacctgtg     4560

agattgggga aaatccaagt taggcaatgc actctgttga gacaataggg aaacaggcac     4620

tccaaaaatt acaaatccct gtggatggta tttgttaact agcaaagtta aatgagtata     4680

tccttcaacc tggcagaccc agttctaaga atccatatga gatgcacttg caagaatatg     4740

aaatagtata tgcacaaaga tcttgattac agcactgttt ctaatagcta cagactggaa     4800

gccagccaaa tctccattga tagggaattg atggaaggaa ctagggtata tctatacaat     4860

gggatactac acagctgtag aaaggactgc gaactatttt tgtagttctg gtctggagaa     4920

atctccagaa tataggaaat gaaaaatgta aagcacagaa gagaatgtat ggtgtgctgt     4980

ctgttgtata acgaagagac aaatggaaaa aatatgtatt tgcttttttt gtaaagcaat     5040

agaagaatta gttataccaa taactaataa aatgatctcc ttgttagtgg tggtagggag     5100

ctagacaagg atggcaacta tttctgtatc ttacatacct tttattttga ggccctgtca     5160

atgttttata taataaacat tttttgaaaa ggcaactctt aaaactaaaa caaacttaac     5220

agtctgtcaa gttggtgata taaccccaca gaagacttac ttcaagtgac ttgaaaactt     5280

agtattttgt ctgtactttg ctaatggaat atatcctaca gaccaaacaa ccacaaataa     5340

atcttaaact gcaaaaaaaa aaaaaaaaaa                                      5370


<210>  659
<211>  349
<212>  PRT
<213>  Homo Sapiens

<400>  659

Met Ala Ala Glu Glu Glu Glu Val Asp Ser Ala Asp Thr Gly Glu Arg 
1               5                   10                  15      


Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Ile 
            20                  25                  30          


Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val Pro Cys 
        35                  40                  45              


Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Lys Ile Trp 
    50                  55                  60                  


Thr Leu Lys Phe Ser His Asn Ile Ser Asn Lys Thr Pro Leu Val Leu 
65                  70                  75                  80  


Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                  90                  95      


Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                 105                 110         


Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu Val Glu 
        115                 120                 125             


Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                 135                 140                 


Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                 150                 155                 160 


Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Asn His Leu Ile Leu Val 
                165                 170                 175     


Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Asp Arg 
            180                 185                 190         


Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                 200                 205             


Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                 215                 220                 


Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                 230                 235                 240 


Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                 250                 255     


Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                 265                 270         


Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Lys Met His Pro Asp Ile 
        275                 280                 285             


Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                 295                 300                 


Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                 310                 315                 320 


Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Glu 
                325                 330                 335     


Phe Asn Gln Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                 345                 


<210>  660
<211>  4548
<212>  DNA
<213>  Homo Sapiens

<400>  660
gggactggag gctgccgagg gggccggcgc ccgagtccgg gattcggcca gtggtgctga       60

gcgagtgctg gaccagcggc cgtcctgtgc acctggcctg tgcgcgtgcc cgctgctcgg      120

cttcacccag actaaggcgc gggcagctgc gggaacaggc ggggtgggcg gagggagacc      180

gggaggcacg ggcgccctgt gcgcggagga ggtgaaggcg gccggggccg ggacgccatg      240

tccatggagg accccttctt tgtggtgaaa ggagaggtac agaaagcagt caacactgcc      300

cagggattgt ttcagagatg gacagagctc ctccaggacc cctccacagc aacaagggaa      360

gaaatcgact ggaccaccaa cgagctgaga aataacctcc ggagcataga gtgggatcta      420

gaggaccttg atgaaaccat cagcatagtt gaagcaaatc ctagaaaatt taaccttgat      480

gcaactgaat tgagtataag aaaagccttc attacaagta ctcggcaagt tgtcagggac      540

atgaaagatc agatgtcaac ttcatctgtg caggcattag ctgaaagaaa aaatagacag      600

gcactgctgg gagacagtgg cagccagaac tggagcactg gaacaacaga taaatatggg      660

cgtctggacc gagagctcca gagagccaat tctcatttca ttgaggagca gcaggcacag      720

cagcagttga tcgtggaaca gcaggatgag cagttggagc tggtctctgg cagcatcggg      780

gtgctgaaga acatgtccca gcgcatcgga ggggagctgg aggaacaggc agttatgttg      840

gaagatttct ctcacgaatt ggagagcact cagtcccggc tggacaatgt gatgaagaaa      900

cttgcaaaag tatctcatat gaccagtgat cggcgccaat ggtgtgccat agccatcctc      960

tttgcagtcc tgttggttgt gctcatcctc ttcttagtgc tgtgacggcg gggcctctgg     1020

gtgcgagttc ctcctgcata tgaaccgagg ggaggaggag aagctgagca cgtgtgacat     1080

tgccgtctac tcacattcct atcctggaaa catactgctg cactgacttt tctccgtgtg     1140

accccacaat tgacatggct cctccatccc agcgctggaa gggccagtgg gaagaggaaa     1200

tagatgtctg cactcctggc tgcagctgga caacagaagc cccatgccgc ctgtccagtt     1260

cggaggagaa ctagctgctg ccttgccttc cgggacctcg tttgctgagg agggacttac     1320

agactccact ggtgttttgc tgttgctcat tccatgcatc tttggcagct cttttcttct     1380

gctcagaccc ttccccgtgc tcagacagtg caccgctgtc ccatctaaag aaacctgtca     1440

ggaatacgag cttctgggta tgtttcgttt cccattgctg tagcatttct tatcccctga     1500

gagctgatga ttattgagga cagaaggctc agaaacagtt tgtgacagaa aatgcagtgt     1560

ttcatttttc agggataaat gctaagataa aattgctttt ccaggtcatt tttttttgtg     1620

gtaagaataa ctaatggaaa ataatgaaac accctggggt ttgggggtgc taacaacttg     1680

tggctttaac tgacaggagc aattaaaaag agcaagaggg ttctgcattg gcatagctta     1740

gggaagggtt aatgatgtcg ccacaggtca gctcctgatc cttgccgact tgatgttgct     1800

gtaccagggc ttcctcccca gaggtgcagc ttgcgttttg agggtgattg ctacatatgt     1860

tgttgctaaa cagctcagta acacacttga atgaatttgg ataccagatt gtcctcatta     1920

cagttctttt actcttaggg cactctacac tgggggttgg ggttgggagt ggttagtaca     1980

tttattacat ttattaagaa acgtaatgac ataaaaggtt agctctgggc cagacttctc     2040

ttactctgtg ggtaatggca aggatgtgta ggtaaacttg gttctttttt ttccctaaga     2100

tgacagcttg attttatcat ctgcagtcaa ataactgagc caatccaaat ttaaatgata     2160

gatgctttaa ttgagtttaa gtagctgaaa ctgctgagac actaaacttt aaccttctga     2220

tgacttttta aaatgcctca aatgtgcaca tgtatatagg atatttttat aacttccctg     2280

atgaataatc tgatattaaa gtagtatttg gacccagagc cagaactcgg tggtggaggc     2340

tgctggtctc tcctcaccac cttcttttgc acttggaaag aacagcaaca tctggataga     2400

gttctggctt tgacttctca tttccttgtc tttttgggtg cattcctcag cacacttttt     2460

ttttaaacct ttttgttttg ttttgtttgt atttcatgtg gttttatttg ggggttttgg     2520

ttttttcacc cttttttgtg atttgcaatg atgtgcttgc ccagctaact tttgaattgc     2580

actttttaat aaatattctt aacaattttt gaagaaggat attttatctc atttgagatc     2640

atggtaggtt aagaaaatat gcctgttgat gaaagctaaa agcaaattta tgaaactaaa     2700

agggtgattg acatccatgt ttacactccg ctctaatgtt tgatatataa ataagttatt     2760

ttcaaattag gaaaaaacag tgagtattac aaagggcttc agatgtttag agtactaggt     2820

tatttatgtt ttacaaagtt tgaatcttct ataaactaag aaaggggatg atccttagat     2880

ttgcattaaa atatagaagt cttttaaagt aaatgtgaac cttgtctaag tactgtaatc     2940

cacacaacac attataagaa gcaaaccagc atcttaagga attataaaat taccctattt     3000

aaaagccatg ctattgttct gctattacca gatttattgt gccacacaaa aggatcatgt     3060

gtgtcagcag gggccgtttg gaacaaacct agtcattaat gagtaagata ctcctgttag     3120

ttcagggacc aagttttatg acccagaggc ttaatgatgt ttggatatat ttcaaatcgg     3180

cgtgcttacc tcactgattt aaattatttt ctaaatagtg gccattgtag acctgactca     3240

ggctgaagct aaatagagaa caatttagaa agttaactaa caatacagtg cattctaccc     3300

gtagggccac catgcccttc tgcccctggc tgatttgatc ctgtgtctga tcccattgca     3360

ccctgactgg gcagtcccta cagaaccagt gttaatttga agggcctcca ctcaggctcc     3420

aaatgtggca gccaaagaga acaatccagg gaacctacat ttatttttaa ggacaaatat     3480

ttcctcctca gtggtcctaa tgttcagggc tttagaggga acccaggtgg tctcttcacc     3540

ctgtgtccta gaatgggaga gtaagtagac agtggtgata accccacact gcttataagt     3600

gcatctttat agtatttggg gctttcctac ccctttagcc ttctgtacct agtaccatat     3660

tccagtttta aagaactggc agaatgtgat ggataacaga ggaagagctc aatttatgtt     3720

tattggaaga acattttact taaatgattt gaggggtggg agggagtgaa ctactgagtt     3780

tgccagagtg aaaatccatc tgaaaaactc agctaccttt agtttttagt cctcattttt     3840

ggtcttgtct ctgcggactg tgaagaatca caatgctcta tatgccctgg actgtgtggc     3900

aaatgcaggt tgcagcgtgt gtgttacatg aggatcttcc acaatttcag aatgcacgcc     3960

agagctgaag ggggaaactt ggtaacttgc ccattattct ctgcttttag ccagagttaa     4020

acagactgat gggtctggta gccaacaact tggcaacttc cactccttct cacctcgtga     4080

gattaagggc tgtgaaaaga aatctagtct aactccaaca gaaatctgtc tctgttaagt     4140

gttttacctt ctgtaagtag agatggtaga gccaagattt ttcttttggt aatttccctg     4200

tctataaagt gagaccaaag ggatatctgt tccctgttac ctttttggag aattcataac     4260

atttgaagat caaaaaattg aatgataaat atgaatggct tttcaattct gtggactttg     4320

taccatttgg cttcaccttg tactgcaaga tgaatttgta aacaaaacaa aattggactg     4380

tctggaaagc taaagttctg aaatatggaa tgtactgcct ctaatttttc tttgtcttcc     4440

tctcactggc atttttttct ctcccaggtt tcttaagaat aatgtttttt aaaggaggct     4500

ttttgcccat caagaataaa aagaaataaa accaaaaaaa aaaaaaaa                  4548


<210>  661
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  661

Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys 
1               5                   10                  15      


Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu 
            20                  25                  30          


Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn 
        35                  40                  45              


Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu 
    50                  55                  60                  


Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu 
65                  70                  75                  80  


Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg 
                85                  90                  95      


Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln 
            100                 105                 110         


Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly 
        115                 120                 125             


Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp 
    130                 135                 140                 


Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala 
145                 150                 155                 160 


Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val 
                165                 170                 175     


Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly 
            180                 185                 190         


Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu 
        195                 200                 205             


Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys 
    210                 215                 220                 


Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile 
225                 230                 235                 240 


Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu 
                245                 250                 255 


<210>  662
<211>  3924
<212>  DNA
<213>  Homo Sapiens

<400>  662
atggagcccc gggctgccgc ggcgggcgag ccagagccgc cggcggcgtc ctcctccttc       60

caggcccggc tctggaagaa cctgcagctg ggggtgggca ggagcaaggg cggcgggggc      120

gggcgcgctg ggggtccaga gcgccgcact gcggacaccc cgtcgccctc cccgccaccc      180

ccggtgggca cagggaatgc accggccagg gggagtggtg caggcagcag gtggagcggc      240

ttcaagaagc ggaagcaagt gctggaccga gtcttctcct cctcgcagcc caacctgtgc      300

tgctcgtcgc cggagcccct ggagcccggc ggcgccggca gagccgagca ggggtccacg      360

ctacgccgcc ggatccgcga gcatttgctc cccgccgtaa aggggcccgc ggcggcctcg      420

ggagcagcgg gagggacgcc tcctggcgga cgctcccccg actcagctcc ttcctcttcc      480

tccgcctcat cctccctgtc ctcctcgccc cagcctcccc cgagggggga ccgcgcccga      540

gatgagggtg cacggcgtca gggccccggg gcgcacttgt gccaccagaa gagctcctct      600

ctgccgggca ccgcctgcct ggagcagctg ctggagccgc cgcctcctcc cgcagagccg      660

gcgcggagtc ccgcggagtc tcgggccccg gagacgggcg aggagcacgg cagcagccag      720

aaaataataa acactgctgg aaccagtaat gcagaagtcc ccttggctga tcccggaatg      780

taccagctgg acattacatt aagaaggggt caaagtttag ctgctcgaga tcgaggaggg      840

acgagtgatc catatgtgaa gtttaaaatc ggaggaaaag aagtttttag aagtaagata      900

atacacaaga acctcaaccc tgtgtgggaa gaaaaagctt gtattctggt tgatcatctt      960

agggagccat tgtatataaa ggtatttgac tatgattttg gactacagga tgactttatg     1020

ggctcagcct ttctggatct gacacaattg gagttaaaca ggcccacaga tgtgaccctt     1080

actctgaaag atcctcatta tcctgaccat gatcttggaa tcattttgct ctcagtcatc     1140

cttaccccta aagaaggaga gtccagggat gtgacaatgc taatgaggaa gagttggaaa     1200

agatcaagta aggaactttc agaaaatgaa gtggttggat cttatttctc tgtgaagtct     1260

ctcttttgga ggacgtgcgg caggccagct cttcctgtcc tgggcttctg cagagcagag     1320

cttcagaatc cttattgcaa aaatgtacaa tttcagaccc aaagtttacg cctatcagac     1380

ctacacagaa aatcgcatct ttggagagga atagtcagca tcaccttgat tgaagggaga     1440

gacctcaagg ccatggattc caacgggttg agcgatccct acgtgaagtt ccggcttggg     1500

catcagaagt acaagagcaa gattatgcca aaaacgttga atcctcagtg gagggaacaa     1560

tttgattttc acctttatga agaaagagga ggagtcattg atatcactgc atgggacaaa     1620

gatgctggga aaagggatga tttcattggc aggtgccagg tcgacctgtc agccctcagt     1680

agggaacaga cgcacaagct ggagttgcag ctggaagagg gtgagggaca cctggtgctg     1740

ctggtcactc tgacagcatc agccacagtc agcatctctg acctgtctgt caactccctg     1800

gaggaccaga aggaacgaga ggagatatta aagagatata gcccattgag gatatttcac     1860

aacctgaaag atgtgggatt tctccaggtg aaagtcatca gagcggaagg gttaatggct     1920

gccgacgtca ctggaaaaag tgacccattt tgtgtggtag aactgaacaa cgatagactg     1980

ctaacacata ctgtctacaa aaatctcaat cctgagtgga ataaagtctt cacgttcaac     2040

attaaagata tccattcagt tcttgaagtg acagtttatg atgaagatcg ggatcgaagt     2100

gctgactttc tgggcaaagt tgctatacca ttgctgtcta ttcaaaatgg tgaacagaaa     2160

gcctacgtct tgaaaaacaa gcagctgaca gggccaacaa agggggtcat ctatcttgaa     2220

atagatgtga tttttaatgc tgtgaaagcc agcttacgaa cattaatacc caaagaacag     2280

aagtacattg aagaggaaaa cagactctct aaacagctgc tactaagaaa ctttatcaga     2340

atgaaacgtt gtgtcatggt gctggtaaat gctgcatact acgttaatag ttgctttgat     2400

tgggattcac ccccaaggag tctcgctgct tttgtgctct ttctctttgt tgtctggaac     2460

tttgagctct acatgatacc actggttttg ttgttactat tgacatggaa ctacttcttg     2520

ataatatcag ggaaagataa caggcaacgt gatacagtag tggaggacat gctagaggac     2580

gaggaagaag aagatgacaa agatgacaag gacagtgaaa aaaagggatt tataaataaa     2640

atctatgcca tccaggaggt atgtgtcagt gtccagaaca tcctagatga agtggcttcc     2700

tttggcgaaa ggataaagaa tactttcaac tggactgtcc cattcttaag ctggctggcc     2760

attgtagccc tctgtgtgtt cacagccatc ctgtactgca ttccgctgag atacattgtc     2820

cttgtctggg gcatcaataa atttacaaaa aagcttcgga gtccatatgc aattgataac     2880

aatgaactac ttgacttcct ttccagagtc ccttcagatg tacaagtggt gcaataccaa     2940

gaactgaaac cagatccttc tcatagccca tataaaagaa agaaaaacaa tcttggctag     3000

ccagctccca gcactgagga gaccagcatc tgtttgggaa gataaaagaa aaagccctca     3060

gcctcagcag catttccttt ctttctgctt tttatttatt ttgccttttt atcatgatcg     3120

agagaatctg taaatagtgt acaaaggcat atgtctttga atatatactt ctattgtaca     3180

gactcaactt gataaaggtt ttgctactgc tgtgtcaaaa ccttgttagc tgtggataat     3240

aatataacac actgaaagaa caaatataag aatgataaca ctggaagata tattcttatc     3300

taattactag tggattaaat actcacctgt gctctgatta aatctacatc aattgtaaat     3360

gtcgatttga ttttaaagtt tttttttaat gcgactattt tttatctgaa aagtaatcca     3420

ttacactttt ctatgtttta tacatttcaa aagggaggga aattccaaag cctgaataat     3480

ggaatggata catttcaatt taacatatat tctggcttta gatcccgaca ttcactcctg     3540

tgcaaattac ttaggtatga cttaggctaa ttttaagcta ataagtgaag gtacattcac     3600

tccctcaaga gaatcaatac tcagaaggtt acaaagtttt ctttatagaa tttcaatcaa     3660

tcattccatc taaaacctta aaatctctac aggactacat aacataaata ctgccagttt     3720

ataaacgatt gcctatctga atttttatac ctaccactac tttaatttat acagttagtt     3780

agcaaattag caacccagta agtacagtta tcaaaaatac taggaaacta tatccatatc     3840

gcttttggtg tcagattgta tctgtgcatc taaaaatatt ttaataaata ctcaagtgct     3900

ctcagagaaa aaaaaaaaaa aaaa                                            3924


<210>  663
<211>  999
<212>  PRT
<213>  Homo Sapiens

<400>  663

Met Glu Pro Arg Ala Ala Ala Ala Gly Glu Pro Glu Pro Pro Ala Ala 
1               5                   10                  15      


Ser Ser Ser Phe Gln Ala Arg Leu Trp Lys Asn Leu Gln Leu Gly Val 
            20                  25                  30          


Gly Arg Ser Lys Gly Gly Gly Gly Gly Arg Ala Gly Gly Pro Glu Arg 
        35                  40                  45              


Arg Thr Ala Asp Thr Pro Ser Pro Ser Pro Pro Pro Pro Val Gly Thr 
    50                  55                  60                  


Gly Asn Ala Pro Ala Arg Gly Ser Gly Ala Gly Ser Arg Trp Ser Gly 
65                  70                  75                  80  


Phe Lys Lys Arg Lys Gln Val Leu Asp Arg Val Phe Ser Ser Ser Gln 
                85                  90                  95      


Pro Asn Leu Cys Cys Ser Ser Pro Glu Pro Leu Glu Pro Gly Gly Ala 
            100                 105                 110         


Gly Arg Ala Glu Gln Gly Ser Thr Leu Arg Arg Arg Ile Arg Glu His 
        115                 120                 125             


Leu Leu Pro Ala Val Lys Gly Pro Ala Ala Ala Ser Gly Ala Ala Gly 
    130                 135                 140                 


Gly Thr Pro Pro Gly Gly Arg Ser Pro Asp Ser Ala Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Leu Ser Ser Ser Pro Gln Pro Pro Pro Arg Gly 
                165                 170                 175     


Asp Arg Ala Arg Asp Glu Gly Ala Arg Arg Gln Gly Pro Gly Ala His 
            180                 185                 190         


Leu Cys His Gln Lys Ser Ser Ser Leu Pro Gly Thr Ala Cys Leu Glu 
        195                 200                 205             


Gln Leu Leu Glu Pro Pro Pro Pro Pro Ala Glu Pro Ala Arg Ser Pro 
    210                 215                 220                 


Ala Glu Ser Arg Ala Pro Glu Thr Gly Glu Glu His Gly Ser Ser Gln 
225                 230                 235                 240 


Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val Pro Leu Ala 
                245                 250                 255     


Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg Gly Gln Ser 
            260                 265                 270         


Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr Val Lys Phe 
        275                 280                 285             


Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile His Lys Asn 
    290                 295                 300                 


Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val Asp His Leu 
305                 310                 315                 320 


Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe Gly Leu Gln 
                325                 330                 335     


Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln Leu Glu Leu 
            340                 345                 350         


Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro His Tyr Pro 
        355                 360                 365             


Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu Thr Pro Lys 
    370                 375                 380                 


Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys Ser Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly Ser Tyr Phe 
                405                 410                 415     


Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro Ala Leu Pro 
            420                 425                 430         


Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr Cys Lys Asn 
        435                 440                 445             


Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu His Arg Lys 
    450                 455                 460                 


Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile Glu Gly Arg 
465                 470                 475                 480 


Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys 
                485                 490                 495     


Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr 
            500                 505                 510         


Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu 
        515                 520                 525             


Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys 
    530                 535                 540                 


Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser 
545                 550                 555                 560 


Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly 
                565                 570                 575     


His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile 
            580                 585                 590         


Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu 
        595                 600                 605             


Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp 
    610                 615                 620                 


Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala 
625                 630                 635                 640 


Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn 
                645                 650                 655     


Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu 
            660                 665                 670         


Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu 
        675                 680                 685             


Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu 
    690                 695                 700                 


Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys 
705                 710                 715                 720 


Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val 
                725                 730                 735     


Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu 
            740                 745                 750         


Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg 
        755                 760                 765             


Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys 
    770                 775                 780                 


Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp 
785                 790                 795                 800 


Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe 
                805                 810                 815     


Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu 
            820                 825                 830         


Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg 
        835                 840                 845             


Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu 
    850                 855                 860                 


Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys 
865                 870                 875                 880 


Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp 
                885                 890                 895     


Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr 
            900                 905                 910         


Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr 
        915                 920                 925             


Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly 
    930                 935                 940                 


Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn 
945                 950                 955                 960 


Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val 
                965                 970                 975     


Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys 
            980                 985                 990         


Arg Lys Lys Asn Asn Leu Gly 
        995                 


<210>  664
<211>  2402
<212>  DNA
<213>  Homo Sapiens

<400>  664
ttatgtttat tgtcctgttc aaatccaagc tctttcacac agaattgtac aagcaaagtt       60

tgagtaacta atcttggggt catattccaa tgtggctccc attaaagcat ttcaaagagt      120

gctagattca ggctcacata tgttacagca acaggctata ctctagggaa agaacaaaac      180

agcttgataa aaactgtttc cttttaagca tatttagaca aatatctatc ctgtattctc      240

tttgccatct agattggagc catggctttg gaacagaacc agtcaacaga ttattattat      300

gaggaaaatg aaatgaatgg cacttatgac tacagtcaat atgaactgat ctgtatcaaa      360

gaagatgtca gagaatttgc aaaagttttc ctccctgtat tcctcacaat agttttcgtc      420

attggacttg caggcaattc catggtagtg gcaatttatg cctattacaa gaaacagaga      480

accaaaacag atgtgtacat cctgaatttg gctgtagcag atttactcct tctattcact      540

ctgccttttt gggctgttaa tgcagttcat gggtgggttt tagggaaaat aatgtgcaaa      600

ataacttcag ccttgtacac actaaacttt gtctctggaa tgcagtttct ggcttgtatc      660

agcatagaca gatatgtggc agtaactaaa gtccccagcc aatcaggagt gggaaaacca      720

tgctggatca tctgtttctg tgtctggatg gctgccatct tgctgagcat accccagctg      780

gttttttata cagtaaatga caatgctagg tgcattccca ttttcccccg ctacctagga      840

acatcaatga aagcattgat tcaaatgcta gagatctgca ttggatttgt agtacccttt      900

cttattatgg gggtgtgcta ctttatcaca gcaaggacac tcatgaagat gccaaacatt      960

aaaatatctc gacccctaaa agttctgctc acagtcgtta tagttttcat tgtcactcaa     1020

ctgccttata acattgtcaa gttctgccga gccatagaca tcatctactc cctgatcacc     1080

agctgcaaca tgagcaaacg catggacatc gccatccaag tcacagaaag catcgcactc     1140

tttcacagct gcctcaaccc aatcctttat gtttttatgg gagcatcttt caaaaactac     1200

gttatgaaag tggccaagaa atatgggtcc tggagaagac agagacaaag tgtggaggag     1260

tttccttttg attctgaggg tcctacagag ccaaccagta cttttagcat ttaaaggtaa     1320

aactgctctg ccttttgctt ggatacatat gaatgatgct ttcccctcaa ataaaacatc     1380

tgcattattc tgaaactcaa atctcagacg ccgtggttgc aacttataat aaagaatggg     1440

ttgggggaag ggggagaaat aaaagccaag aagaggaaac aagataataa atgtacaaaa     1500

catgaaaatt aaaatgaaca atataggaaa ataattgtaa caggcataag tgaataacac     1560

tctgctgtaa cgaagaagag ctttgtggtg ataattttgt atcttggttg cagtggtgct     1620

tatacaaatc tacacaagtg ataaaatgac acagaactat atacacacat tgtaccaatt     1680

tcaatttcct ggttttgaca ttatagtata attatgtaag atggaaccat tggggaaaac     1740

tgggtgaagg gtacccagga ccactctgta ccatctttgt aacttcctgt gaatttataa     1800

taatttcaaa ataaaacaag ttaaaaaaaa acccactatg ctataagtta ggccatctaa     1860

aacagattat taaagaggtt catgttaaaa ggcatttata attattttta attatctaag     1920

ttttaataca agaacgattt ccctgcataa ttttagtact tgaataagta tgcagcagaa     1980

ctccaactat cttttttcct gtttttttta aatttgtaag taattttata aaatccacct     2040

cctccaaaaa agcaataaaa aaaaaacaaa ctataataag cttttctgat tcttttcaaa     2100

acattcctgg taagttccta aagacataat ttgcttctat gatgtcaact ttcttactaa     2160

taactggtta tcatgacaaa tgttaggttt atcatatata gtctaggtgt aatcctcaga     2220

ctatcatttt catctgggtt ccaatttctt aacttcctaa agaattcatc tgtttataca     2280

agtctaccac tgccgattga ctaaaaaata cattatccca tgcataaaat gtcctatttt     2340

catttaaaca ctttattttt gagtaataaa aatatgtacc acaataaatt attgttaatt     2400

aa                                                                    2402


<210>  665
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  665

Met Ala Leu Glu Gln Asn Gln Ser Thr Asp Tyr Tyr Tyr Glu Glu Asn 
1               5                   10                  15      


Glu Met Asn Gly Thr Tyr Asp Tyr Ser Gln Tyr Glu Leu Ile Cys Ile 
            20                  25                  30          


Lys Glu Asp Val Arg Glu Phe Ala Lys Val Phe Leu Pro Val Phe Leu 
        35                  40                  45              


Thr Ile Val Phe Val Ile Gly Leu Ala Gly Asn Ser Met Val Val Ala 
    50                  55                  60                  


Ile Tyr Ala Tyr Tyr Lys Lys Gln Arg Thr Lys Thr Asp Val Tyr Ile 
65                  70                  75                  80  


Leu Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Phe Thr Leu Pro Phe 
                85                  90                  95      


Trp Ala Val Asn Ala Val His Gly Trp Val Leu Gly Lys Ile Met Cys 
            100                 105                 110         


Lys Ile Thr Ser Ala Leu Tyr Thr Leu Asn Phe Val Ser Gly Met Gln 
        115                 120                 125             


Phe Leu Ala Cys Ile Ser Ile Asp Arg Tyr Val Ala Val Thr Lys Val 
    130                 135                 140                 


Pro Ser Gln Ser Gly Val Gly Lys Pro Cys Trp Ile Ile Cys Phe Cys 
145                 150                 155                 160 


Val Trp Met Ala Ala Ile Leu Leu Ser Ile Pro Gln Leu Val Phe Tyr 
                165                 170                 175     


Thr Val Asn Asp Asn Ala Arg Cys Ile Pro Ile Phe Pro Arg Tyr Leu 
            180                 185                 190         


Gly Thr Ser Met Lys Ala Leu Ile Gln Met Leu Glu Ile Cys Ile Gly 
        195                 200                 205             


Phe Val Val Pro Phe Leu Ile Met Gly Val Cys Tyr Phe Ile Thr Ala 
    210                 215                 220                 


Arg Thr Leu Met Lys Met Pro Asn Ile Lys Ile Ser Arg Pro Leu Lys 
225                 230                 235                 240 


Val Leu Leu Thr Val Val Ile Val Phe Ile Val Thr Gln Leu Pro Tyr 
                245                 250                 255     


Asn Ile Val Lys Phe Cys Arg Ala Ile Asp Ile Ile Tyr Ser Leu Ile 
            260                 265                 270         


Thr Ser Cys Asn Met Ser Lys Arg Met Asp Ile Ala Ile Gln Val Thr 
        275                 280                 285             


Glu Ser Ile Ala Leu Phe His Ser Cys Leu Asn Pro Ile Leu Tyr Val 
    290                 295                 300                 


Phe Met Gly Ala Ser Phe Lys Asn Tyr Val Met Lys Val Ala Lys Lys 
305                 310                 315                 320 


Tyr Gly Ser Trp Arg Arg Gln Arg Gln Ser Val Glu Glu Phe Pro Phe 
                325                 330                 335     


Asp Ser Glu Gly Pro Thr Glu Pro Thr Ser Thr Phe Ser Ile 
            340                 345                 350 


<210>  666
<211>  6804
<212>  DNA
<213>  Homo Sapiens

<400>  666
gcagtgcaat tccatgttcc tcttaagtat gttagcccta ccgggagctg agctggccag       60

tctacttgga gaggaaaagt agatctgggg aaggtggaag ggtcagttcc taagtgactt      120

cctcctcggg gatggtaagg gcatttgctg atctccagtg actgcctggt gcctcatggt      180

cagactcggc tgtctcactc ccagatatct gattttgcaa aaagggacac acctatctgc      240

agcaaagaag acactgacca gattgcgagc ggtgcttttg gatgctctgt agccacccgg      300

ggcccaggag gactgactcg gcagcaggat tcgtgcatgg gaatcggaga ccatggcagt      360

gcagctggtg cccgactcag ctctcggcct gctgatgatg acggagggcc gccgatgtca      420

agtacatctt cttgatgaca ggaagctgga actcctagta cagcccaagc tgttggccaa      480

ggagcttctt gaccttgtgg cttctcactt caatctgaag gaaaaggagt actttggaat      540

agcattcaca gatgaaacgg gacacttaaa ctggcttcag ctagatcgaa gagtattgga      600

acatgacttc cctaaaaagt caggacccgt ggttttatac ttttgtgtca ggttctatat      660

agaaagcatt tcatacctga aggataatgc taccattgag cttttctttc tgaacgcgaa      720

gtcctgcatc tacaaggagc ttattgacgt tgacagcgaa gtggtgtttg aattagcttc      780

ctatatttta caggaggcaa agggagattt ttctagcaat gaagttgtga ggagtgactt      840

gaagaagctg ccagcccttc ccacccaagc cctgaaggag cacccttccc tggcctactg      900

tgaagacaga gtcattgagc actacaagaa actgaacggt cagacaagag gtcaagcaat      960

cgtaaactac atgagcatcg tggagtctct cccaacctac ggggttcact attatgcagt     1020

gaaggacaag cagggcatac catggtggct gggcctgagc tacaaaggga tcttccagta     1080

tgactaccat gataaagtga agccaagaaa gatattccaa tggagacagt tggaaaacct     1140

gtacttcaga gaaaagaagt tttccgtgga agttcatgac ccacgcaggg cttcagtgac     1200

aaggaggacg tttgggcaca gcggcattgc agtgcacacg tggtatgcat gtccggcatt     1260

gatcaagtcc atctgggcta tggccataag ccaacaccag ttctatctgg acagaaagca     1320

gagtaagtcc aaaatccatg cagcacgcag cctgagtgag atcgccatcg acctgaccga     1380

gacggggacg ctgaagacct cgaagctggc caacatgggt agcaagggga agatcatcag     1440

cggcagcagc ggcagcctgc tgtcttcagg ttctcaggaa tcagatagct cgcagtcggc     1500

caagaaggac atgctggctg ccttgaagtc caggcaggaa gctctggagg aaaccctgcg     1560

tcagaggctg gaggaactga agaagctgtg tctccgagaa gctgagctca cgggcaagct     1620

gccagtagaa tatcccctgg atccagggga ggaaccaccc attgttcgga gaagaatagg     1680

aacagccttc aaactggatg aacagaaaat cctgcccaaa ggagaggaag ctgagctgga     1740

acgcctggaa cgagagtttg ccattcagtc ccagattacg gaggccgccc gccgcctagc     1800

cagtgacccc aacgtcagca aaaaactgaa gaaacaaagg aaaacctcgt atctgaatgc     1860

actgaagaaa ctgcaggaga ttgaaaatgc aatcaatgag aaccgcatca agtctgggaa     1920

gaaacccacc cagagggctt cgctgatcat agacgatgga aacattgcca gtgaagacag     1980

ctccctctca gatgcccttg ttcttgagga tgaagactct caggttacca gcacaatatc     2040

ccccctacat tctcctcaca agggactccc tcctcggcca ccgtcgcaca acaggcctcc     2100

tcctccccag tccctggagg gactccgaca gatgcactat caccgcaacg actatgacaa     2160

gtcacccatc aagcccaaaa tgtggagtga gtcctcttta gatgaaccct atgagaaggt     2220

caagaagcgc tcctctcaca gccattccag cagccacaag cgcttcccca gcacaggaag     2280

ctgtgcggaa gccggcggag gaagcaactc cttgcagaac agccccatcc gcggcctccc     2340

gcactggaac tcccagtcca gcatgccgtc cacgccagac ctgcgggtcc ggagtcccca     2400

ctacgtccat tccacgaggt cggtggacat cagccccacc cgactgcaca gcctcgcact     2460

gcactttagg caccggagct ccagcctgga gtcccagggc aagctcctgg gctcggaaaa     2520

cgacaccggg agccccgact tctacacccc gcggactcgt agcagcaacg gctcagaccc     2580

catggacgac tgctcgtcgt gcaccagcca ctcgagctcg gagcactact acccggcgca     2640

gatgaacgcc aactactcca cgctggccga ggactcgccg tccaaggcgc gccagaggca     2700

gaggcagcgg cagcgggcgg cgggcgcact gggctcagcc agctcgggca gcatgcccaa     2760

cctggcggcg cgcgggggtg cggggggcgc ggggggcgcg gggggcggtg tgtacctgca     2820

cagccagagc cagcccagct cgcagtaccg catcaaggag tacccgctgt acatcgaggg     2880

cggcgccacg cccgtggtgg tgcgcagcct ggagagcgac caggagggcc actacagcgt     2940

caaggctcag ttcaagacgt ccaactccta cacggcgggc ggcctgttca aggagagctg     3000

gcgcggcggc ggcggcgacg agggcgacac gggccgcctg acgccgtcgc gatcgcagat     3060

cctgcggact ccgtcgctgg gccgcgaggg cgcccacgac aagggcgcgg gccgtgccgc     3120

cgtctcagac gagctgcgcc agtggtacca gcgttccacc gcctcgcaca aggagcacag     3180

ccgcctgtcg cacaccagct ccacctcctc ggacagcggc tcgcagtaca gcacctcctc     3240

ccagagcacc ttcgtggcgc acagcagggt caccaggatg ccccagatgt gcaaggccac     3300

gtcagctgcc ttacctcaaa gccagagaag ctcgacaccg tcaagtgaaa ttggagccac     3360

ccccccaagc agcccccacc acatcctaac ctggcagact ggagaagcaa cagaaaactc     3420

acccattctg gatgggtctg agtctccacc tcaccaaagt actgatgaat agaggagcta     3480

caatgatagc tgtttcctgg attcctccct ctatccagaa ctagctgatg tccagtggta     3540

cgggcaggaa aaagccaagc ccgggaccct cgtgtgagcc agcccggcct aatctgaccg     3600

cctcaacgcc attctgagat cacctcactg cctctcattt gccttaccca gacgcaccgt     3660

caccctgcac cagctttggc cctcagcact ttttttctcc tgtctccgca ttccctcccc     3720

cttgaaaacc tgactgagga gacattctgg aaggttccgg tcccactgtg tgtcccctgg     3780

cgctcttgcc catagagagc cagacaccaa tcctcaatgg caccttggtg gcttccctct     3840

gccatgacag cccctaggcc aggaaccatc aggggggcca gccggcatcc aattcctgcg     3900

gataagtagc gttgggagag aacgggaaag gggacttgag ttacagggtg acccagaaag     3960

acgattcagc tgtgtccagc ctgccaccca tacgtaggcc aaccaagcac ttcatgaaga     4020

ggaggcctcg tggcatattc agtttacacc tgaaatattc cttgatggga cagcttgtgg     4080

ggatggctat gggggaaggg gaggttgaga aaggaagttc tcgacaccag aaatgcatcg     4140

gaggaccaca atcagttcta tgctgccaaa gattaaaaat aaataaaaac ataaaaaatt     4200

aagaggggcc aagaggaaga cattctttct gcaaggaaat ttcttttaaa ttctgaactg     4260

ctactacaca caagtgaaag tcaaccctat gtaaactggt gtcctctctc tagccctctc     4320

ccttactggc ccacttctct ctccgtagag agcctgaaaa actgccccaa tgccacggta     4380

aaggcgagga agtcttggct ggcgttgctg actcacagtc gccatccatc tggacacaaa     4440

gagagacctg tgggagtcgt agagggtact gttagccccg gtccatgcag ggggttcagc     4500

cgagcccaag actcaaagct gctttccttt caggatttgt agtaacgtaa ggtgataatg     4560

gccaaaagtg gttctctctc attaaaccaa ccagtaaaag cgtatcctat ttttttgcac     4620

aaggtgtttc attttcgttt ttatgggaaa ccaagggaaa agcacattgc gatccattca     4680

gtgtttaact gtcgtggctc attttctgtt cgttagcact tgtgtgacaa aagagctcag     4740

atccgacttc tcctatgtgt cacttattcc aagaacccaa ctatgccctt aggtagaaag     4800

atttgactcg tgtgtctact agccaacagg cagagcaggg ttgaaaaaaa tatcagctcc     4860

caaagggccc atgtgtctac atcatcagtt actgtcatgc accacatttg tgtgcagata     4920

ccaaaagagg aggaaagaag aaaaaaatta atgtgtggga gctgcacgtt tacatgtttt     4980

gagctatgct tcaaacacaa ctggaaagcc atcaatcttc aaaggcctca aaaatacttt     5040

tatagtaaca agtgcacgac tttagttggg ttattcaaga tggcacaaaa aggtttccgc     5100

agaggtggta tgctgtgctt ttggcgcaag tggtgggggg atggggtggg ggtggaattt     5160

ttttctcact ctaatgactt cctattggaa aggcattgac agccagggac aggagccagg     5220

gtgggggtag ttttgtggga aagcagaact gaagttagct taagcataaa aacaaagaaa     5280

aatcttcgct tttcatgtat gtggaatcca agaataacca taggctctac cagaccagaa     5340

gggtaaggat ggacactaaa atgaaacaaa taccaaggta ttccttctgc tgcagcctgg     5400

agaccaccga gagtcgagct ggggcacaca cacacctggc cgggacccgg cagggacaag     5460

gcgggccgtg gcctcctcca ccaagtctct ctagacaatt cagggcctgc tttccccagc     5520

tccatgcatg gctggactgg tgattccagg gtgcagaagg gattcatatt cccagaacgc     5580

tttaagtgta cacctgcagg ataaagagat accggttaca ttattaaatg attctaggga     5640

ttcactgggg gatatttttg ttgcttttac tttcatggtt agagctacaa agaacagtga     5700

tttttttttt ttctcccttc cccattcaga aacattatac attgggccat ttttctttct     5760

cccaaagaag attcatggat agtcagactg aactgtgtgc aacaggaaaa gtcaaaaggg     5820

aaaaggtagc tgatgaggtt acatggttac atgttctaca tcatgcatag tagcttgaaa     5880

tctagtctgg agaaaactgg atcaagattc tagcccactg gagttgcaag gaatgagagg     5940

caaaaattct aaagatttgg gttatatttt caacttgggg gacagagaga aatggagagc     6000

aggaattaca gttccaacaa acatcatgat agtctggtag tcaagacaga gattaagtaa     6060

aacaggtttt actgtttagc tgagttcagt taatacaaaa tgtacataaa acgttagtcc     6120

tttgagactg acatgattaa tgatcagtgt ggtgggaaat gatgtagtta ttgtacacaa     6180

gcacttgcaa actctttatc cctatttctt taaaacaaaa taaggtgaaa tacgaagtcc     6240

ttggtctgat ataaagcccc tattggattc ttcggatgcg taaaagaaat tgcctgtttc     6300

agccagaaga ctggtgaaaa cacatacatc agactatgtt gtgagccagg ttgatttttt     6360

attttattat atgcaggtga gtgttgaaac tgttaaaatt ccaatttgtt ttcattcagt     6420

attagtttag ttctaaatat agcaaacccc atccaggtgc tatcagatga ccagttactg     6480

cttagttaac taggtgtaaa gttttacata tacattaatg tcaatagttt attacaagtt     6540

gtgtaaaatg gactctagtt taataatggg ggaaaaaaga ttaggttgct cctgaaactg     6600

actgtagagc atgtaaaatg attttactgg attctgttca actgtaatca atgaaaaaga     6660

tgtacgttgt agacaaagtt gcagaattaa aaaaagaaat ctgcttttaa tttattcttt     6720

ttgtattaag aatttgtata gtacctttac attttgcaaa acagtgttgt caacacttat     6780

taaagcattt tcaaaatgaa aaga                                            6804


<210>  667
<211>  1039
<212>  PRT
<213>  Homo Sapiens

<400>  667

Met Ala Val Gln Leu Val Pro Asp Ser Ala Leu Gly Leu Leu Met Met 
1               5                   10                  15      


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
            20                  25                  30          


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
        35                  40                  45              


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
    50                  55                  60                  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
65                  70                  75                  80  


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
                85                  90                  95      


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
            100                 105                 110         


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
        115                 120                 125             


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
145                 150                 155                 160 


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
                165                 170                 175     


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
            180                 185                 190         


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
        195                 200                 205             


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
    210                 215                 220                 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
225                 230                 235                 240 


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
                245                 250                 255     


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
            260                 265                 270         


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
        275                 280                 285             


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
    290                 295                 300                 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
                325                 330                 335     


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
            340                 345                 350         


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala Lys 
    370                 375                 380                 


Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu Glu 
385                 390                 395                 400 


Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg Glu 
                405                 410                 415     


Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro Gly 
            420                 425                 430         


Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys Leu 
        435                 440                 445             


Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu Arg 
    450                 455                 460                 


Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala Arg 
465                 470                 475                 480 


Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln Arg 
                485                 490                 495     


Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu Asn 
            500                 505                 510         


Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln Arg 
        515                 520                 525             


Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser Ser 
    530                 535                 540                 


Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr Ser 
545                 550                 555                 560 


Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg Pro 
                565                 570                 575     


Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu Arg 
            580                 585                 590         


Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys Pro 
        595                 600                 605             


Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val Lys 
    610                 615                 620                 


Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro Ser 
625                 630                 635                 640 


Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln Asn 
                645                 650                 655     


Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met Pro 
            660                 665                 670         


Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser Thr 
        675                 680                 685             


Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu His 
    690                 695                 700                 


Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu Gly 
705                 710                 715                 720 


Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr Arg 
                725                 730                 735     


Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr Ser 
            740                 745                 750         


His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn Tyr 
        755                 760                 765             


Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln Arg 
    770                 775                 780                 


Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly Ser 
785                 790                 795                 800 


Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Ala 
                805                 810                 815     


Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln Tyr 
            820                 825                 830         


Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro Val 
        835                 840                 845             


Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val Lys 
    850                 855                 860                 


Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe Lys 
865                 870                 875                 880 


Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg Leu 
                885                 890                 895     


Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg Glu 
            900                 905                 910         


Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu Leu 
        915                 920                 925             


Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser Arg 
    930                 935                 940                 


Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr Ser 
945                 950                 955                 960 


Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg Met 
                965                 970                 975     


Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln Arg 
            980                 985                 990         


Ser Ser Thr Pro Ser Ser Glu Ile  Gly Ala Thr Pro Pro  Ser Ser Pro 
        995                 1000                 1005             


His His  Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1025                 1030                 1035             


Glu 
    


<210>  668
<211>  644
<212>  DNA
<213>  Homo Sapiens

<400>  668
tcaccaagga gaggagagga gacaggacca tgtggctgtc cccatctctg ctgcttctca       60

tcctcccagg ttactccatt gccgctaaaa tcactggtcc aacaacagtg aatggctcgg      120

agcagggctc attgactgtg cagtgtgctt atggctcagg ctgggagacc tacttgaagt      180

ggcggtgtca aggagctgat tggaattact gtaacatcct tgttaaaaca aatggatcag      240

agcaggaggt aaagaagaat cgagtttcca tcagggacaa tcagaaaaac cacgtgttca      300

ccgtgaccat ggagaatctc aaaagagatg atgctgacag ttattggtgt gggactgaga      360

gacctggaat tgatcttggg gtcaaagttc aagtgaccat taacccaggc acacaaactg      420

cagtctcaga atggacaacc acaacagcaa gcctggcttt cacagctgca gccacccaga      480

agaccagcag ccccctcacc aggtccccgc tcaagagcac ccacttcctg ttcctgttcc      540

tcctggagct gcctctgctc ctgagcatgc tggggaccgt cctctgggta aacagaccac      600

aaagaaggtc ttgaaggagg aggagtcagc ccgatgatga gagt                       644


<210>  669
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  669

Met Trp Leu Ser Pro Ser Leu Leu Leu Leu Ile Leu Pro Gly Tyr Ser 
1               5                   10                  15      


Ile Ala Ala Lys Ile Thr Gly Pro Thr Thr Val Asn Gly Ser Glu Gln 
            20                  25                  30          


Gly Ser Leu Thr Val Gln Cys Ala Tyr Gly Ser Gly Trp Glu Thr Tyr 
        35                  40                  45              


Leu Lys Trp Arg Cys Gln Gly Ala Asp Trp Asn Tyr Cys Asn Ile Leu 
    50                  55                  60                  


Val Lys Thr Asn Gly Ser Glu Gln Glu Val Lys Lys Asn Arg Val Ser 
65                  70                  75                  80  


Ile Arg Asp Asn Gln Lys Asn His Val Phe Thr Val Thr Met Glu Asn 
                85                  90                  95      


Leu Lys Arg Asp Asp Ala Asp Ser Tyr Trp Cys Gly Thr Glu Arg Pro 
            100                 105                 110         


Gly Ile Asp Leu Gly Val Lys Val Gln Val Thr Ile Asn Pro Gly Thr 
        115                 120                 125             


Gln Thr Ala Val Ser Glu Trp Thr Thr Thr Thr Ala Ser Leu Ala Phe 
    130                 135                 140                 


Thr Ala Ala Ala Thr Gln Lys Thr Ser Ser Pro Leu Thr Arg Ser Pro 
145                 150                 155                 160 


Leu Lys Ser Thr His Phe Leu Phe Leu Phe Leu Leu Glu Leu Pro Leu 
                165                 170                 175     


Leu Leu Ser Met Leu Gly Thr Val Leu Trp Val Asn Arg Pro Gln Arg 
            180                 185                 190         


Arg Ser 
        


<210>  670
<211>  2833
<212>  DNA
<213>  Homo Sapiens

<400>  670
ttagcacagt gactacagga atcacagccc agacacaaaa gcaggaaacc ctttgaccgg       60

gctccttcct attgcaccaa cagccttgtg ttgctgcaat gaaaacactt ccccaagcag      120

ctgtggccaa gagacgcaga aactgccttg tccacgggcc ccgcctcaga ctccaacact      180

cacaagagag cagaggagcc ccaagtcttg gggaccacag aagatgccat gtgctccacg      240

atgtcggccc ccacctgcct ggcccacttg cctccctgct tcctgctgct ggcactggtc      300

cttgtcccct cagatgcctc tgggcagagc agcaggaatg actggcaggt gctacagccc      360

gagggcccca tgctggtggc agaaggtgag acacttctac tgaggtgtat ggtggtcggc      420

tcctgcactg atggtatgat aaaatgggtg aaggtgagca ctcaggacca acaggaaatt      480

tataacttta aacgtggctc cttccctggg gtaatgccca tgatccaacg gacatcagaa      540

ccactgaatt gtgattattc catctatatc cacaatgtca ccagggagca cactggaacc      600

taccactgtg tgaggtttga tggtttgagt gaacactcag aaatgaaatc ggatgaaggc      660

acctcagtgc ttgtgaaggg agctggggac cctgaaccag acctgtggat catccagccc      720

caggaattgg tgttggggac cactggagac actgtctttc tgaactgcac agtgcttgga      780

gacggtcccc ctggacccat caggtggttc cagggagctg gtctgagccg ggaggccatt      840

tacaactttg gaggcatctc ccaccccaag gagacagcgg tgcaggcctc caacaatgac      900

ttcagcattc ttctgcaaaa cgtctccagt gaggatgcag gcacctatta ctgtgtaaag      960

tttcagagga aacccaacag gcaatacctg tctggacagg gcaccagcct gaaagtgaaa     1020

gcaaaatcta cctcttccaa agaggcagaa ttcaccagtg aacctgcaac tgagatgtct     1080

ccaacaggcc tcctggttgt gttcgcacct gtggtcctgg ggctgaaggc aattaccttg     1140

gctgcactcc tactggccct ggctacctct cggaggagcc ctgggcaaga agatgtcaag     1200

accacaggcc cagcaggagc catgaacacc ttagcatgga gcaagggtca agagtgaggg     1260

gtcagcccca gagtgaggac cctctgagtt ggagaggagc cagggctcct caaccatttc     1320

cctacctcca gtcccagcct ctaggtgccc ccaggcctca tgacaaactc ctagatccct     1380

acatctggtt ttggtccacc tagtgaaatt cccttctttg caccgggctt ccctctaaaa     1440

tgtctccctt tctctttttg gcctgttcaa gacctccttg cttttcagtc cctggctcag     1500

tctctcctca acacccttgc ccctgctgca gccctttctg gtgcgccctg cccctttccc     1560

cacctcgcta catccttctt ggcctccaac atccaactca gagtcttctt cccaggagat     1620

gtctgtaaga atctctgaac tcaaccagcc agaccatctg tgcccctcca tctacacctt     1680

tctccccact ccttcctgcc ttccttccat ccccctcatg gctggcttgg gcaggtataa     1740

tattagaatg caggttcagc aactataaca aagctcttaa ataacagtgg cttaaaccag     1800

tggaaatcaa ccagaaagtt gaccatcagc aggccaagca atacagagac tccctggtat     1860

tgagacccag gattcactga tctcattgct accaggtcca ccttctaggc agccagactg     1920

gaaaagaggg caggaaaggg gagcaggacc ctccccttta agtgcacagt caggaacttg     1980

gccacctcac ttatctctac ttggctggaa tgtggtcaca tggtcacacc tagctgcaag     2040

aaacactggg agatgtagtc tttatttctg gcagcaatgc gcccagctgc aagttttcac     2100

tagagaaacc agatggcaga tatcagggga taaccagtta tctccaccac agcagcatac     2160

agacagcctc tcacctgccc tgtgggacac ctgagttcaa tgcccagcta gctagccagc     2220

acttcttccc actatcacct cccctggggc agcatgatgt ggggcagtag ttcccaagat     2280

gagtgatttt gcccccactg gacttttggc aatgtctaga gatgtttttg gttggcacaa     2340

cctggggggg tgctaccacc atctagtgga ctgagaagcc ctgacatggg gaagagtgtg     2400

catgcccagg agtcagacac acctgccttt aaccctgagg cctctgcctc ctccctgtgc     2460

accctcagtg actaatcaga gtcccttccc atcacggaac atccaggata ctaatgtgga     2520

cttctctgca ttgtgtaaga accaattcaa gaccaggcac ggtggcttat gcatgtaatc     2580

ccagcacttt gggaggccga ggtgggtgga tcacctgagt tcaggagttt gagaccagcc     2640

tggctaacat ggtgaaacct cgtctctact aaaaatacaa aaaattagcc aggcgtggtg     2700

gtgtgcacct gtaatcccag ctacttggga ggatggggca ggagaaccgc ttgaactggg     2760

aggcagaggc tgcagtgagc tgagatcgcg ccattgcact ccagcctggg caacaagagc     2820

aaaactccgt ctc                                                        2833


<210>  671
<211>  342
<212>  PRT
<213>  Homo Sapiens

<400>  671

Met Cys Ser Thr Met Ser Ala Pro Thr Cys Leu Ala His Leu Pro Pro 
1               5                   10                  15      


Cys Phe Leu Leu Leu Ala Leu Val Leu Val Pro Ser Asp Ala Ser Gly 
            20                  25                  30          


Gln Ser Ser Arg Asn Asp Trp Gln Val Leu Gln Pro Glu Gly Pro Met 
        35                  40                  45              


Leu Val Ala Glu Gly Glu Thr Leu Leu Leu Arg Cys Met Val Val Gly 
    50                  55                  60                  


Ser Cys Thr Asp Gly Met Ile Lys Trp Val Lys Val Ser Thr Gln Asp 
65                  70                  75                  80  


Gln Gln Glu Ile Tyr Asn Phe Lys Arg Gly Ser Phe Pro Gly Val Met 
                85                  90                  95      


Pro Met Ile Gln Arg Thr Ser Glu Pro Leu Asn Cys Asp Tyr Ser Ile 
            100                 105                 110         


Tyr Ile His Asn Val Thr Arg Glu His Thr Gly Thr Tyr His Cys Val 
        115                 120                 125             


Arg Phe Asp Gly Leu Ser Glu His Ser Glu Met Lys Ser Asp Glu Gly 
    130                 135                 140                 


Thr Ser Val Leu Val Lys Gly Ala Gly Asp Pro Glu Pro Asp Leu Trp 
145                 150                 155                 160 


Ile Ile Gln Pro Gln Glu Leu Val Leu Gly Thr Thr Gly Asp Thr Val 
                165                 170                 175     


Phe Leu Asn Cys Thr Val Leu Gly Asp Gly Pro Pro Gly Pro Ile Arg 
            180                 185                 190         


Trp Phe Gln Gly Ala Gly Leu Ser Arg Glu Ala Ile Tyr Asn Phe Gly 
        195                 200                 205             


Gly Ile Ser His Pro Lys Glu Thr Ala Val Gln Ala Ser Asn Asn Asp 
    210                 215                 220                 


Phe Ser Ile Leu Leu Gln Asn Val Ser Ser Glu Asp Ala Gly Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Lys Phe Gln Arg Lys Pro Asn Arg Gln Tyr Leu Ser Gly 
                245                 250                 255     


Gln Gly Thr Ser Leu Lys Val Lys Ala Lys Ser Thr Ser Ser Lys Glu 
            260                 265                 270         


Ala Glu Phe Thr Ser Glu Pro Ala Thr Glu Met Ser Pro Thr Gly Leu 
        275                 280                 285             


Leu Val Val Phe Ala Pro Val Val Leu Gly Leu Lys Ala Ile Thr Leu 
    290                 295                 300                 


Ala Ala Leu Leu Leu Ala Leu Ala Thr Ser Arg Arg Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Asp Val Lys Thr Thr Gly Pro Ala Gly Ala Met Asn Thr Leu Ala 
                325                 330                 335     


Trp Ser Lys Gly Gln Glu 
            340         


<210>  672
<211>  2718
<212>  DNA
<213>  Homo Sapiens

<400>  672
ggaacacaat gacttggatc aaacagccta aatgggaaga aggacatttt tgctgcatca       60

aggaagccgt taaactcctg ctaagctaac tagctctttt ttatgggtcc atgcacacga      120

ccgaactcct ctttcactga ccagagatta tttctgacaa cccaggatat cccgaaagct      180

tggaggcata tggctggaaa atgaaacgac ccaggacatc gtttctggct gcatcattat      240

tttgtgtcgc gtagtaccag atgggcagtc agtgagcggc gcagggatgt gaacggacgg      300

ttttataatg tgaaaatttt cccttggtaa agctaaaaca gatttaattt ccctctcttt      360

tctttcacta cttccccctc tttattcccc ctctgtctgc aatatcagtg aactcaactt      420

tgcagtgagg tggccaaaaa gagagagaat gaggagatct tgatcatctt agtgtcggag      480

gagtcgcagc ggactgggaa ctgcagctgc gaccccccgc gtcctgtgcg gatttcaggg      540

ctgataccgc ataggcggtt atggaaagga cggtacaccg gagcggcgga ggatagagac      600

cctggccccc ggagaggtct gctgatttcg cagcagcctt cgaagccgtg gctgcctttc      660

atctgctgcg ttttattact attatcgccg ttccggaaaa gtcatggaag acagcccgct      720

gccagacctc agagacatcg agctgaagct ggggcgcaaa gtacccgaga gtctagtgcg      780

ctctctccgt ggggaggagc cggttcccag ggaaagggac agggacccct gcggggggag      840

cggtggtggt ggcggcggcg gcggcggctg cagtagcagc agcagctact gcagcttccc      900

tccctccttg tcgtcctcct cttcgtcctc cccaacctct ggctccccac gaggtagcca      960

ctctagcgcc ctggagaggc tagaaaccaa gcttcacctc ctcaggcaag agatggttaa     1020

cctcagagcc acagacgtca ggctcatgcg ccagttgctt gtaatcaatg agagcatcga     1080

gtccatcaag tggatgatcg aagaaaaagc caccattacc agcagaggca gcagcctcag     1140

tggcagcctg tgcagtttgt tggagagtca gagcacctcc ttacgtggca gctacaacag     1200

cctacacgat ggcagtgatg ggctggatgg catttccgtg ggaagttatc tggacacgtt     1260

ggcggatgat gtcccaggcc atcagacccc ttcagacttg gaccaattca gtgacagctc     1320

cctcatagag gactcacagg cactacacaa gcgtcctaaa ttggattctg aatactactg     1380

ctttggctag tgacagtttt ttgcatggga ctggtgtgca atgaacttgt atttatcctt     1440

cttctccgct gctatatttt tggtgtgatt tttattttaa taagatgacc tttttaaaag     1500

aagctgattt tgaaactgct taatggtatt gctgttgctc ctaatacttc tcatctgagc     1560

tgatttattt ttctctgtta catctctatt ttttatttat tacaatgatt ttctcccttc     1620

ttttacagta gcacaaacaa agtaggggga aaagaataag caataattat gtttttgctt     1680

ttgttttcag agcaatgggt cagggattac aagaaaaact ttgctaaatt ttacaataaa     1740

ccaaagtctg ataacagtta atgttgctgc ttgcgtcctt aaatgactta aggtttcatc     1800

ttccagaaga tattgagata tattactgtt tgcatatcag gttgaacaaa atgcttggaa     1860

caaaattaag cattatttct agaccacaac attctagtgt ataatcaacc atactgttag     1920

tcacacacgc ccacatgaca atcatctgaa agtccccaac tatacacatt ctgttcaacc     1980

aactcaccct tgtgttggta ctttagatta acattttgtc atcagtgatt ctaactcaaa     2040

tcatatgttt atttgtgtaa taaaatgtat tattctccca aatttcaagg aataattgag     2100

attaagtatg gaggccattc aaggcaaaaa tgtcctaaat ttaattgcat tttgagattt     2160

tgttggcatt tacttgtatg tattttgtga ttctgatagg atgtataaat acttagatgc     2220

atacaagccg atggatagaa agacagataa atatcccgat agcctactat cagcatccta     2280

ctactgcttc cctaaagcag aattgttatt catttaagaa gtctaatatg atatacattc     2340

atcctagtat aaataaataa tctctaagtt ttctgaaatg gaatatttaa cgcacataga     2400

cagtggatat ttactttaaa tataatgtta ttaatcctct gcatttcttt tatcttgata     2460

actcctagtg agggaatcta attaagattt catgctgttc tttgtaatga taaatgtttc     2520

cggactaaac actctataat acaaatcaaa aaatcttcct tcttataact gagaaatgtt     2580

tcacccaaat ttcctttgtt attatatatt tactacacat gttgaattta ttattgttta     2640

tttccaaggc atgtattatt caatttctaa ttaaaatata tcagggctta aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaa                                                   2718


<210>  673
<211>  228
<212>  PRT
<213>  Homo Sapiens

<400>  673

Met Glu Asp Ser Pro Leu Pro Asp Leu Arg Asp Ile Glu Leu Lys Leu 
1               5                   10                  15      


Gly Arg Lys Val Pro Glu Ser Leu Val Arg Ser Leu Arg Gly Glu Glu 
            20                  25                  30          


Pro Val Pro Arg Glu Arg Asp Arg Asp Pro Cys Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Cys Ser Ser Ser Ser Ser Tyr Cys Ser 
    50                  55                  60                  


Phe Pro Pro Ser Leu Ser Ser Ser Ser Ser Ser Ser Pro Thr Ser Gly 
65                  70                  75                  80  


Ser Pro Arg Gly Ser His Ser Ser Ala Leu Glu Arg Leu Glu Thr Lys 
                85                  90                  95      


Leu His Leu Leu Arg Gln Glu Met Val Asn Leu Arg Ala Thr Asp Val 
            100                 105                 110         


Arg Leu Met Arg Gln Leu Leu Val Ile Asn Glu Ser Ile Glu Ser Ile 
        115                 120                 125             


Lys Trp Met Ile Glu Glu Lys Ala Thr Ile Thr Ser Arg Gly Ser Ser 
    130                 135                 140                 


Leu Ser Gly Ser Leu Cys Ser Leu Leu Glu Ser Gln Ser Thr Ser Leu 
145                 150                 155                 160 


Arg Gly Ser Tyr Asn Ser Leu His Asp Gly Ser Asp Gly Leu Asp Gly 
                165                 170                 175     


Ile Ser Val Gly Ser Tyr Leu Asp Thr Leu Ala Asp Asp Val Pro Gly 
            180                 185                 190         


His Gln Thr Pro Ser Asp Leu Asp Gln Phe Ser Asp Ser Ser Leu Ile 
        195                 200                 205             


Glu Asp Ser Gln Ala Leu His Lys Arg Pro Lys Leu Asp Ser Glu Tyr 
    210                 215                 220                 


Tyr Cys Phe Gly 
225             


<210>  674
<211>  4318
<212>  DNA
<213>  Homo Sapiens

<400>  674
ttctgctgcc gctaggggta gcggcggcgg cggcggctgc ggctcgggag cgcggctgct       60

ttgagggctc gggaacctta cagagtgggg acgtggggag gctagagggt gagaaagctg      120

gcgggagagt agggcggcgc tggaggaggg cggtgcgtgg ctgactcatc ctctggaaga      180

tcagactgac agagacacac actagcccgc cccgcccgcc cgcgccgctc ctcctcagcc      240

gggaggcgcc cgcccgcacc gaccgcccgc cctctccggg cgctgtccgg gcccggccgt      300

ctcagagaaa gtttttccca tcggaggggc gggagccgcc gcgggccttt tggaaaggaa      360

gtggggacgg aacaggaggc gagagccgcg cgggcccgcg gagtgcatgg tgcccggcgc      420

ctcggctgcc tggcaggagg acctcggggc ggggtcgagc tgagcccagc tccttctcgc      480

ctcagccgcg ccagaaaccg ccttgccgga cggccgcggg ggtcccagct cctcagctcg      540

ccatgtcccg gctgctgccg ctgctgagga gccggaccgc gcgcagcctg aggccgggcc      600

cggccgccgc cgccgcgccc cgcccgccgt cctggtgctg ctgcgggcgg gggctgctgg      660

cgctcgcgcc ccccggcggc ttgccgggcg gccccaggcg gctgggcacg caccccaaga      720

aggagcccat ggaggcgctg aacacggcgc agggcgcgcg cgacttcatc tacagcctgc      780

actccacgga gaggagctgc ctgctcaaag agctgcaccg cttcgagtct attgccattg      840

cccaagaaaa attggaagct ccaccaccca ccccaggaca gctgagatat gtattcatcc      900

acaatgcgat acctttcata gggtttggct ttttggataa tgcaattatg attgttgctg      960

gaacccatat tgaaatgtct attggaatta ttttgggaat ttcaactatg gcagctgctg     1020

ctttgggaaa tcttgtgtca gatctagctg gacttggact tgcaggctac gttgaagcat     1080

tggcttccag gttaggcctg tcaattcctg atctcacacc aaagcaagtt gacatgtggc     1140

aaacacgtct tagtacacat ttgggcaaag ctgttggggt gactattggc tgcattctag     1200

gaatgtttcc tttaattttc tttggaggag gtgaagaaga tgaaaaactg gaaacgaaaa     1260

gttaatcctc ttagaatacc tataaaaaga tgtaaactaa tgtacctcag taattaaata     1320

tgctgtcaca acatttagga attaagacag taacagtata gatatgggat caaataattt     1380

agcatgtatt atggaaaaca ctaacttatt gtggcttgat cttcttagga catctttttt     1440

aaaaagctgt ttagtatcat tttgtgtata ttgttgaaat gctttttcat caatagcagt     1500

caacatttta tcctttcttt ttatattcat aatgttattt aagtgtcatt gatgtactgt     1560

attgacttgg ggtttgctta tttgttactt aacatgtgta catgcatgaa agcatttttc     1620

gttgttccct gatagttaca tttcaacctt gggatttttc caaattactt aagatgttta     1680

atgtcagtta aagatttttt taccctcttt ttgggaacat caattttgta ctgttatgca     1740

gtaaacattt ataataatat aatttcagtc atttcttaac tgtcacatct attgaaaatg     1800

gatatagata caggttttaa gtattttaag tatatattac ttattttaat tttctgactt     1860

tactatttta agggccagag ggttaatcac aaagagcaat tatgtggtct ccctgctaca     1920

tgaaaccgtg tatactaaca agcgtacaat ttttagttga ttttttttaa ccttttagtt     1980

tcccagtttt gaataattac atggtggatt ctgacttttg aggggaagca aatgattatt     2040

ttagagtctt tgaaatgggg attgtggaat tagattgaac taagggattt aacatgatgc     2100

ttggaaatta agagactaaa gcttttttta aaaaaaggtg gaaaatagga actgtcaaga     2160

aggtttatgg tataaatgat gaagttgaag tgatgtttga aagattaatg agatacaatt     2220

tatattattt ggtaaggttt ttttttttcc ctccaaagat gtcatcttct catctgaatg     2280

gaataagtct gaatacccca tattcatact cctaatctca ttatatctta tttagtgaat     2340

tttatttatg aataatttct gttgaagtga aaactagata tttaatattt tgcttttttg     2400

ctacatagtc tactcaaaaa ttacatgagg agaaatcctt tttccctttg tttttctttt     2460

ttcttctttt gtggtattta aagcatattt taggttgaag ttacttattt ctagtcttgt     2520

acttctggct taagtataac catgtaagaa ttataaattt tagttttctg aacccttaaa     2580

cttttttagc atgtggtctg ttacacatgc taaaaaatta gtcttacttg taacagcgta     2640

attaaacaca tcatggagga gagaaactta aaattaaaat agtattttgg cttttgaagt     2700

tatttgtgtt gctaaataga tgcagaggtt ttacagcagt ttattttaag gttttattta     2760

tacataatta ctttgaactc ttcagagtag atattttttc acaaggcagt ttgtcataaa     2820

ttctctcatg cgcttcagaa tgcataagtg ccatccttta atcatagact ttgaggagag     2880

aaagcataaa aatatagcat ataatctaaa aataaatata taacatgcac aaataatgtg     2940

acattcttac tgaatcaaat catgattcta gaacttgaga tcttaaatag aatttcggtt     3000

tgtatcttcc atataataac cacacacaga taaccacaca aaaaatcctt tgtaaaattt     3060

ctgattgata ggattagagt gcttaaattt ttgggggggg aagggtgggg taaagtgtaa     3120

gtgctttctt ttgtccctaa cttgtgtatt gatggcagtc cactctgttt tctaaaaatg     3180

tattttactg tggtgcttaa cttcttatta attaaatccc gtatcagaaa ccttgcctgt     3240

gactttagaa agggcttttg attattgttt tttcttcttg ctcttgaaag taatctggtc     3300

ccagggaatt actggtttaa ctgaacatct ccagaattat ttaaggtgtc aaaatatata     3360

accttcacat tgaaagataa ttttaattta tgggcataat aaaaatttga atcattcagg     3420

taattttcaa aaaatggaga ccatttgtct ttaactgaag gtatatgttt aagatcatag     3480

tctaccctag tatggtgctt tgccacaaag tgatttctga agaatggttc tttttaagat     3540

aatgacttca tatgatcatt gtttcatgtt acttgccaca aataacttta atttaggttg     3600

aaactggaac tgtttgtttc tcatattagc tacttctcta ttaggagcac aagaaccata     3660

gttaaatgca acatgagcta ctttagtcct gtttgtttaa atttgtgttg tccatgtatt     3720

atgatttatt aacttgttga tgcatgtaaa ttgggtgcat tttgttgcca tgtatgttaa     3780

atggtgacca atgtttttac aaaggaattg aacaaaaaaa gtatctttta agaaatttgg     3840

aatgtggttt tgattttgaa atttgatttc ttactaatct cagagggcct tggtatattc     3900

tgttactaaa gcaaacagga ttaatgaata cggatttgtt acaaggtggc agcaatgtca     3960

ctgagatagt gaatggaaca atttaccacc tccctggaat ctgcacctga gatacaacat     4020

cagcgtatga gtgaagagtg agcccataga aaagctttag atagactcac ataagtcaca     4080

ctgatgggta tttacagcag atatatccaa gctgtttatg taatagtctc atttacttta     4140

ttctttttct ctagaacata aattttgaag gtaatggaag tttatctttt ataccaaaag     4200

tttgtatgag ccattttgaa gtaaatcttt ctaattttag aattatattt tctcgccatc     4260

ttaagacagt atattaaata taatataacc tttttcttag tggctaaaaa aaaaaaaa       4318


<210>  675
<211>  240
<212>  PRT
<213>  Homo Sapiens

<400>  675

Met Ser Arg Leu Leu Pro Leu Leu Arg Ser Arg Thr Ala Arg Ser Leu 
1               5                   10                  15      


Arg Pro Gly Pro Ala Ala Ala Ala Ala Pro Arg Pro Pro Ser Trp Cys 
            20                  25                  30          


Cys Cys Gly Arg Gly Leu Leu Ala Leu Ala Pro Pro Gly Gly Leu Pro 
        35                  40                  45              


Gly Gly Pro Arg Arg Leu Gly Thr His Pro Lys Lys Glu Pro Met Glu 
    50                  55                  60                  


Ala Leu Asn Thr Ala Gln Gly Ala Arg Asp Phe Ile Tyr Ser Leu His 
65                  70                  75                  80  


Ser Thr Glu Arg Ser Cys Leu Leu Lys Glu Leu His Arg Phe Glu Ser 
                85                  90                  95      


Ile Ala Ile Ala Gln Glu Lys Leu Glu Ala Pro Pro Pro Thr Pro Gly 
            100                 105                 110         


Gln Leu Arg Tyr Val Phe Ile His Asn Ala Ile Pro Phe Ile Gly Phe 
        115                 120                 125             


Gly Phe Leu Asp Asn Ala Ile Met Ile Val Ala Gly Thr His Ile Glu 
    130                 135                 140                 


Met Ser Ile Gly Ile Ile Leu Gly Ile Ser Thr Met Ala Ala Ala Ala 
145                 150                 155                 160 


Leu Gly Asn Leu Val Ser Asp Leu Ala Gly Leu Gly Leu Ala Gly Tyr 
                165                 170                 175     


Val Glu Ala Leu Ala Ser Arg Leu Gly Leu Ser Ile Pro Asp Leu Thr 
            180                 185                 190         


Pro Lys Gln Val Asp Met Trp Gln Thr Arg Leu Ser Thr His Leu Gly 
        195                 200                 205             


Lys Ala Val Gly Val Thr Ile Gly Cys Ile Leu Gly Met Phe Pro Leu 
    210                 215                 220                 


Ile Phe Phe Gly Gly Gly Glu Glu Asp Glu Lys Leu Glu Thr Lys Ser 
225                 230                 235                 240 


<210>  676
<211>  3981
<212>  DNA
<213>  Homo Sapiens

<400>  676
cgggctgaga gggacctggg gagctgcggc ctggccgggg cggcgcactc aggtggcctc       60

gcttccctgc gggtcaccgc ccgccactcg cacagctagg tcggcctgtt gggatcggga      120

gaggtgggcg cacgagtttt agtgcgggag tccggggtgc gggcggagtc ctattgtccc      180

cgtgcacccg ggcggcagca cctccgggtc cctctttaaa ccgagcgtcc ggcgaccttt      240

ctttgtgctt agggagtcga aagcggcatc ttctccgaga gaagtcgcct actggggggt      300

ggcgctgggg aggtaacaat gggcgcccat tgtcctccga gggtccaacg gtgacccccc      360

cccgcgcgcg cgcccggcca ccggttggcc ccgggccagg gcacaggtac cgcggctggg      420

agggtcggcc ccgctgcccg cgccctccgc cccgccccag tgagtccccg cgccgccggc      480

cccgccccgc gccgccccgc cctccgcagg ttcagtcctc gcgtccggcc gccccgcgct      540

cagtcgcgcg caccttctct cgcggccggg ggaccgcagc gcggggctag cccggagacc      600

cggccaccgg cctggggcgc cttcacgccg tctcggagcg gataatgcgg tgagcaggca      660

ccacgccggc agactcggct ggatctgcgc acagcggcag ggattgcgtg cgcccgcggg      720

aggcccgggg cagcggctgg gatcctcagc ggcggccggt ttgtcctggt tgtggtcaag      780

actggatgat gtaactggct ctctaggaag cctcacttgg ccgtaacctc aggaaggttc      840

tctttgaccc catctcattt cgaagccact tctgaagcca cttgagaaaa atgatgtgac      900

agttcctatc aaaaaggatt cagaaacata taccatctgt gaagaaagtg gccctttctc      960

ccgcttgcaa aatagacatt ctcaaattcc aaaatgccag ccaagacccc aatttacctg     1020

aaagcagcca ataacaagaa aggaaagaaa tttaaactga gggacattct gtctcctgat     1080

atgatcagtc ccccgcttgg agactttcgc cacaccatcc acattggcaa agagggccag     1140

cacgatgtct ttggagatat ttcctttctt caagggaact acgagctttt acctggaaac     1200

caggagaaag cacacctggg ccagttccct gggcataatg agttcttccg ggccaacagc     1260

acctcggact ctgtgttcac agaaacgccc tccccggtgc tcaaaaatgc catctccctc     1320

ccgaccattg gaggatccca agctctcatg ttgcccttat tgtcaccagt gacatttaat     1380

tccaaacagg agtccttcgg gccagcaaag ctgcccaggc ttagctgcga gcccgtcatg     1440

gaggaaaaag ctcaggagaa aagcagtctg ttggagaatg ggacagtcca ccagggagac     1500

acctcgtggg gctccagcgg ttctgcatct cagtccagcc aaggcagaga cagccactcc     1560

tccagcctgt ccgaacagta ccccgactgg ccagccgagg acatgtttga ccatcccacc     1620

ccatgcgagc tcatcaaggg aaagactaag tcagaggagt ccctctctga ccttacaggt     1680

tccctcctct ccctgcagct tgatcttggg ccctcacttt tggatgaggt gctgaatgta     1740

atggataaaa ataagtaaca agatgccaac ttttttcctt tggggtaaaa ggtacaaaaa     1800

caaactaacc acagttgaag agaagggctt ccggagctgt atttgcagtt ttgtgttggg     1860

ttttctaaaa taatattctt acaaagtatt tttttacctg ttatgccctg tttgcaaaaa     1920

caatttagaa aaaaacaaca aagcaaaacc tatcttggca aaaaaaggaa gtgagtcaga     1980

gcccattttc aggaggcatt ggtgatgttc ggctcacata ttgtttgcag acacacaaga     2040

aatctggctt ggccaggatt ggcactagct atgaagggct gagcgagtca cattaaggaa     2100

cttcacggaa ctttatagca ctccgacatt ttctgagcaa gaggaagtca aaatttattt     2160

aacacctaag cctttttgta gactcttttc tatatattgc ttaggctcac catagcgaat     2220

tctccagtgt taaaactttt ctgttttcac atttgaactt tatgggtttt ggggattttc     2280

ttgtagttct tatatatccc tatatattat atctatattg caaaattttg actgtcagct     2340

acatgttggt aagacacagg caaagtatta ctgtaactaa gttattttta aagttaaaat     2400

atatttttac gtgcctttgg ctttttattg cagagtctac attttataga ttctacatca     2460

gatgttgtca cttatttcca ttgggattcc attgtaagct gtgtatgtgc gtgtttggaa     2520

aagtgtattc atacttagtt tttttttctt catctgttat catactttta acagcaacca     2580

ataacggatt gtaaagtgta aaggcacagg ttactcatga tgcttctgca gagactgtgg     2640

gctacaccac atatgttatt tggaaatata ggtattttag tacagtacat acttgcatta     2700

cataggtact tcaagcaaca caataaaaag taaatgataa agtgaacttg cttgtttata     2760

gtaataaaca agaccataag agaataagta tagctagaga aattgcttct ctgaaatgta     2820

catgagccct taaggtaaga gatgatttcc atctactctc attttgatta cttccttatg     2880

gtttgagagg ctagaaactg agcctctcta cttttggaaa aatgaacatg tgaggtcaga     2940

tttttttttt tttttttaag tcagcactga tgccaccctc tcagtggtca tttctgagca     3000

tcttcctgac ttgaacacct tctacagcaa actcttgcaa gtccagtttc atccctgtaa     3060

ggcaaatgtc ttttcacgca gaaagtgcca tatagacgag ataaaggcag ctaaaacgag     3120

ggcagtagag agcacttacc cgaccccaag gtgccagaga tgccctgagg atggtggtta     3180

aggaaacagg agcaggaaat gtacacacag attcctgtcc ctttgccaac tactccttcc     3240

ccatcaaaga aaaacacttg cacacagtaa ctaccagctc cttctctcaa acttgtattt     3300

ctcctggaaa tgtatctcag aaatgacctc ctctcccaac cacttcaacg attctttctt     3360

tgggtttggg gttcttgcag ttctatcatc taaaataacc tttggactgc aggtaaaatg     3420

caattaggac aactaaccaa gtagacgaaa caagttcccc taggcagggg tgtccaatat     3480

tttagcttcc ctggaccgca ttggaagaat tttcttgggc cacatgtaaa acacactaac     3540

actaaccata gttgatgagc ttaaaaaaat aaaaatagaa aattgcaaaa aaaaaaaaaa     3600

aaaaaaatct cagactgttt taagaaagtt taaaaatttg tgttggactt catgcgggcc     3660

acaggttgga caagcttgcc ctagggcatt gtgtgctttc cgtaacttct cagttgtatt     3720

tcgttatcca tgactctcca gtgttttttc tgttggacca cacccgtcac agttcacagt     3780

tccaaagaga aatttcccag cctattctaa atcttgttaa tgacgaagag tccaatgtat     3840

ctcattattt gtagccaatt ttagactctt ttcaatacct cccccccatt ttaattagta     3900

ttgatcatat tcagtctttc attttactct tcatctgtag cgtgacctca aggtaaagat     3960

gaaactattt catgaaaagg g                                               3981


<210>  677
<211>  155
<212>  DNA
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (149)..(149)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  n is a, c, g, or t

<400>  677
maktykaann kkgkkkrdsd msgdrhthgk ghdvgdsgny gnkahgghnr anstsdsvtt       60

svknastggs amsvtnsksg akrscvmkak ssngtvhgdt swgssgsass sgrdshssss      120

ydwadmdhtc kgktksssdt gssdgsdvnv mdknk                                 155


<210>  678
<211>  6917
<212>  DNA
<213>  Homo Sapiens

<400>  678
cttttccttt ttgatccatt caaaaattac tcattgcaaa ttcccggact gctaggcgag       60

gagagggaag ggggcggagg agacagggct actgcaggcg cagagctggg ggcagccggg      120

ggcccgagtg gctgaggctg gtcccgcagc ggccgcttgc cggcgttctg gctcctgtgg      180

cctcaccagg aagcgtcaga gtcccgacac tggggaagct cggagcgccg cctccgctgc      240

cgccgcctcc tgcctggctc tgggtccccg agccccctcc cctggcccag cccgactccc      300

tcctccttcc cgaaccatcc ggctcgggct ccttccctgg cgatggctgg ccgctgagcc      360

atggctcagt acggccaccc cagtccgctc ggcatggctg cgagagagga gctgtacagc      420

aaagtcaccc cccggaggaa ccgccaacag cgccccggca ccatcaagca tggatcggcg      480

ctggacgtgc tcctctccat ggggttcccc agagcccgcg cacaaaaagc cttggcatcc      540

acgggaggaa gaagtgttca ggcagcatgt gactggttat tctcccatgt cggtgacccc      600

ttcctggatg accccctgcc ccgggagtac gtcctctacc tccgtcccac cggcccctta      660

gcacagaagc tttccgactt ttggcagcag tcgaagcaga tctgcgggaa gaacaaggca      720

cacaacatct tcccccacat cacactctgc cagttcttta tgtgcgagga cagcaaggtg      780

gatgccctgg gggaagccct gcagaccacg gtcagtcgct ggaaatgtaa gttctcggcc      840

ccgctgcccc tggagctcta tacgtcgtcc aacttcatcg gcctctttgt aaaggaagac      900

agtgcggagg tcctcaagaa gtttgctgct gactttgctg cagaggctgc atccaaaacc      960

gaagtgcatg tggaacctca taagaagcag ctacatgtga ccctggctta ccacttccaa     1020

gccagccacc tacccaccct agagaaactg gcccagaaca ttgacgtcaa gctagggtgt     1080

gactgggtgg ctaccatatt ttctcgggat atccgatttg ctaaccatga gacattacag     1140

gtcatctacc cctatacccc acaaaatgac gatgagctgg agctggtccc cggggacttc     1200

atcttcatgt ctccaatgga gcagaccagc accagcgagg gttggatcta tggcacgtcc     1260

ttaaccaccg gctgctctgg actcctgcct gagaattaca ttaccaaggc tgatgaatgc     1320

agcacctgga tatttcatgg ttcttattca atcttaaata catcgtcatc caactctctc     1380

acgtttgggg atggagtatt ggagaggcgg ccttatgagg accaggggct cggggagacg     1440

actcctctta ctatcatctg ccagcccatg cagccgctga gggtcaacag ccagcccggc     1500

ccccagaagc gatgcctttt tgtgtgtcgg catggtgaga ggatggatgt tgtgtttggg     1560

aagtactggc tgtcccagtg cttcgatgcc aaaggccgct acatacgcac caacctgaac     1620

atgcctcata gtttacctca gcggagtggt ggtttccgag attacgagaa agatgctccc     1680

atcactgtgt ttggatgcat gcaagcaaga ctagtgggtg aagccttatt agagagcaat     1740

accattatcg atcatgtcta ttgctccccg tcccttcgct gcgttcagac tgcacacaat     1800

atcttgaaag gtttacaaca agaaaatcac ttgaagatcc gtgtagagcc cggcttattt     1860

gagtggacaa aatgggttgc tgggagcaca ttacctgcat ggatacctcc atcagagtta     1920

gctgcagcca acctgagtgt tgatacaacc tacagacctc acattccaat cagcaaatta     1980

gttgtttcag aatcctatga tacttatatc agtagaagtt tccaagtaac aaaagaaata     2040

ataagtgaat gtaaaagtaa aggaaataac atcctgattg tggcccacgc atcttccctt     2100

gaagcgtgta cctgccaact tcagggcctg tcacctcaga actccaagga cttcgtacaa     2160

atggtccgaa agatcccata tctgggattt tgttcctgtg aagaattagg agaaactgga     2220

atatggcagc tgacagatcc accaatcctt cctcttaccc atggaccaac tgggggcttc     2280

aactggagag agaccttgct tcaagaataa accacaccag tgaacaagaa ggaaaggcct     2340

tttggagtgt gtctttctgt gtgtttaaaa acagtgggaa aatccacacc acactctaag     2400

tggacagctc agaataattt agcatatttc ctttcacact taaagttctt aagatgagac     2460

tgtgtaaatg agagaaagac ttgattcaga ggaaaaaaat gtgttctctc tggactcttg     2520

cctagctcac aaggctttgg agaattgtct tcctaaatcg gggcacctgc tacagaagag     2580

aatgtttcgt tccctctggg tatgcacagc taaggggcct catttctccc agagggagct     2640

gctggcccgc tctaaggggt gcaagaggaa ggagtgtgcc cagaccagct gggggagcat     2700

tgaaaggaca gcttggggat ggaatttttt tttttttatc tccattttcc agttaggtag     2760

agccaagctg aggaatcctt ttaagattat tagaaaacat gccctgaaga gagttgttct     2820

taggttacac atgaaatcct accgtcacta gcccccatac accagtgttg ctggctgaag     2880

atacccgctt aaggatgcta acatttaccc tggtactgcc acattttctc tagagcagct     2940

ggcccttctt gctacagccc tatcccccct ccttgcttct gtgaaatggg gagacaaagc     3000

acttttgctc tccaaagcac ttttggatac tcaggaggaa agataagata catgtttgaa     3060

gtattcaatc ataggagcaa agaacttgca aaatatgaag tgacttggaa ttaaccatgt     3120

tgtagcctaa cgtgctactg catttctaaa tcatcaatat ttgcttgtct ttgcccctag     3180

actctagact atgttaacta gttaaggatg ttacattttg aaaggatgta tgttagatat     3240

attatttgca gcaagaagtt cattctgtgc aatatggaca tgtttgcaaa ccataccaag     3300

ggtcaggttg ttgtacactt acagtacgtg tcaaccataa tggaacatcc acaaatgcat     3360

caattatacc agggatgtat agtaagtcag ggaactaata taaatgatga cagtcatggc     3420

tgcactgcta cttgtgctgt cgttttgttt gtttttctat gataatttaa aatacatagg     3480

tagggctact gaggaaattt ggagagccac attctgtggt ttctcattat acttacttcc     3540

tgcatttaga gggagtttat ttaaaagaaa taaatgacaa tcaaaccaaa tcatcagtta     3600

tcaatgtctg tttaattgtg tgactatctg actgttgatg gccacagatg atggtctcct     3660

atggtatagt tcactctgta gaagatgtat gcaaagtgaa atgccagccc tttaaagaga     3720

cattagttag tgtaaaatgg atctttacat gttgcagtaa cattgactat gtttcaaaac     3780

tcagatgcat aaaacgtaag gtatataaaa atacatctat gcttgcgttt gaaactacaa     3840

cttgataacc cctagaaaga agaggacatg aaaggatgct ggctatatat gttaatgagc     3900

aaaaggatta tagttgtttt gttttgtttt tagagacagg gtctcactat aatgcttaga     3960

ctggtcttga actcctgggc tcaagcgatc ctcctgcccc tgtctcccaa agtgctagga     4020

ttacaggtgt gagccaccac acctggccca tagttgtatt ttttttaggt cacttagaaa     4080

aatatgtcat gtattttaca ttttgagaaa caaatcaatc atggtttctt ctagcgttgc     4140

gcaaacactg acccagcttc tgggtatgga aataaccctg tgatgatgtg ttaatataaa     4200

atgttgggag ggaatattcc caataaaggt cttaagagaa aagtcacatt acaagtaatg     4260

taatggctct accattcatt cttctggtat ttgtaatgaa gtgaatccac tgtttaatca     4320

gatccataat ctttaacaga ttcaccacaa attttcatgg gcgttgagtg ctcagaataa     4380

tgcttgaaca cctcaccttg aaactgtagc agtgtgttct gggcagtatc tgtaatgtat     4440

gaaatagagt ctggaatagg ttatccactc catcttctag gttatcttag ttgtatgacg     4500

aactgataaa tctgtctgac tgggctacaa tccattgttc ttagtccaat atggacactg     4560

ccttaggcaa tggtctatat aagcaaaagg agatagagat ctgaaataat tttccgaata     4620

attcaggtgg aaaacaagaa agattgtatt tctctgcttt catttcaatt tcattatttc     4680

aaattgcttg tcaaaatggc ccaaaagatc tgaattcaca ttaagttccc cttgcacact     4740

tacctattta aaaaactaaa cttgcactgc aactgagaaa ttatttgtaa atcatgtggc     4800

atctatgtat aataaaagaa agagacaact atattactca atttcatata catccaaaaa     4860

gtataggcta atatatataa cctgaagttg cagctggttc tttttgatct gaagctgatg     4920

cttattaaaa caaatgatgt atggggagag gagaaggaag ggcaaggaag gaattgacag     4980

ataagaagca aatggtttct tgtacagagg aattttgttt taatgtagaa agttatttga     5040

aataaactag gtgaaatgaa attaactaaa ggttttaatc tgggattgaa agcctgaaag     5100

catttcctgc ttctacaagt gtgccacatc aatccggtaa tgccccagtg ttattcacag     5160

acagaacttt gtttcctgtg attttaaaat accgcgtctg ttcctccatg gaccagagta     5220

attggcacat tttaatgcat aagctggggg tttcattttc ccaggctctc ttcaccatca     5280

ctgcattggt agctaggagc ttattgcttc accccagtat ggagttcaga ttacagtgtt     5340

ttccattaca tttagattca tagaatctga atggctgatt aaatggccat ctgatggctg     5400

aaagaggggc gtatttttca ctctgtagtg aaaggcttgg aggagtttct actttttatt     5460

ttaattatac tttaaccaaa gaattatttt aaagtaacct tatatttaaa agatgatttt     5520

gcaaaaaata aaaaataaaa aatatgcctt ctggagtgat gtctgtttgg taaatcattg     5580

ttgataattt ccttgttagt ggtatttgga atgcatatag attgtcttgt cattgtgctt     5640

aacattacca taagtgtgtc ttttccactc aactagctgt attcgtatta aaatgaagtc     5700

tcttatttca attacctagt gttgttggga actaattgaa cagctacagt aaaagaagtt     5760

cctatctcat tgcctttgtg gaaaggcttc cctatgtggt aaaagaaagg cattcctccg     5820

taacctaggc actctgcaag tccagtgttt aatttcaaag cagtgatgaa ttgctctttt     5880

gaaattactc taagtaatcc atgtgttaga atacagatga acctccgttt gatttcacag     5940

ccttcagcac aggcaactgt tactgagtct gcacgaactt agataatgag gtgcagggtt     6000

atttgcattt aaattgcaat ccagcacacg tgtgagaaag aagaggcact agtctaaaag     6060

gctgcattgc ggggagagat gagacaggca gaggagggtg gggtaaagag cgatttaaca     6120

tctatttagg ttaatgttca ctttacaaag gtgatggggg atattttgtt aggtgatagc     6180

agaagctttt catttttaaa catagaatta aaattggatt tgcttctctt taatacttca     6240

acatattgaa tttccctagg aaagtgacta gctataatga aaattcaagc gaaaagggaa     6300

aaagattgta aatgcagatg aaataacttc atttttaagt acaaataata gtaggattgg     6360

tgtatgtagg tttaaaatta tagtgatgac tagtcgaact taatatacaa tcagttcttg     6420

caaatacttt acacttagct gccattacac aacaaattgg aattttccag ctgttcaact     6480

atcatggact ctgtacagga tagatgtgta taatggaaaa tatgtactgc ttctttcttt     6540

gattgccact caagatggaa acaccatgcc aaggcatttt ggttatacac agatcattct     6600

aaacctgtta ttttggagag gtgtattggt ttctttctca tttataaggc tattgtattt     6660

ttttttgtat gtgattcagg tgtatttatt tgaagactat ttgtagttat aggaaaacca     6720

cacctacctg tattgccaaa ttctttgtaa actctccgtg gcacttgtgc tttcctggct     6780

gagagctctc ccctgttgat acagctatgg caccattgta attacagatg cacctttcag     6840

gagcatctcc attaaatggt tcatagatga tttaataaaa agaaacttct cagttgatcc     6900

agaaaaaaaa aaaaaaa                                                    6917


<210>  679
<211>  649
<212>  PRT
<213>  Homo Sapiens

<400>  679

Met Ala Gln Tyr Gly His Pro Ser Pro Leu Gly Met Ala Ala Arg Glu 
1               5                   10                  15      


Glu Leu Tyr Ser Lys Val Thr Pro Arg Arg Asn Arg Gln Gln Arg Pro 
            20                  25                  30          


Gly Thr Ile Lys His Gly Ser Ala Leu Asp Val Leu Leu Ser Met Gly 
        35                  40                  45              


Phe Pro Arg Ala Arg Ala Gln Lys Ala Leu Ala Ser Thr Gly Gly Arg 
    50                  55                  60                  


Ser Val Gln Ala Ala Cys Asp Trp Leu Phe Ser His Val Gly Asp Pro 
65                  70                  75                  80  


Phe Leu Asp Asp Pro Leu Pro Arg Glu Tyr Val Leu Tyr Leu Arg Pro 
                85                  90                  95      


Thr Gly Pro Leu Ala Gln Lys Leu Ser Asp Phe Trp Gln Gln Ser Lys 
            100                 105                 110         


Gln Ile Cys Gly Lys Asn Lys Ala His Asn Ile Phe Pro His Ile Thr 
        115                 120                 125             


Leu Cys Gln Phe Phe Met Cys Glu Asp Ser Lys Val Asp Ala Leu Gly 
    130                 135                 140                 


Glu Ala Leu Gln Thr Thr Val Ser Arg Trp Lys Cys Lys Phe Ser Ala 
145                 150                 155                 160 


Pro Leu Pro Leu Glu Leu Tyr Thr Ser Ser Asn Phe Ile Gly Leu Phe 
                165                 170                 175     


Val Lys Glu Asp Ser Ala Glu Val Leu Lys Lys Phe Ala Ala Asp Phe 
            180                 185                 190         


Ala Ala Glu Ala Ala Ser Lys Thr Glu Val His Val Glu Pro His Lys 
        195                 200                 205             


Lys Gln Leu His Val Thr Leu Ala Tyr His Phe Gln Ala Ser His Leu 
    210                 215                 220                 


Pro Thr Leu Glu Lys Leu Ala Gln Asn Ile Asp Val Lys Leu Gly Cys 
225                 230                 235                 240 


Asp Trp Val Ala Thr Ile Phe Ser Arg Asp Ile Arg Phe Ala Asn His 
                245                 250                 255     


Glu Thr Leu Gln Val Ile Tyr Pro Tyr Thr Pro Gln Asn Asp Asp Glu 
            260                 265                 270         


Leu Glu Leu Val Pro Gly Asp Phe Ile Phe Met Ser Pro Met Glu Gln 
        275                 280                 285             


Thr Ser Thr Ser Glu Gly Trp Ile Tyr Gly Thr Ser Leu Thr Thr Gly 
    290                 295                 300                 


Cys Ser Gly Leu Leu Pro Glu Asn Tyr Ile Thr Lys Ala Asp Glu Cys 
305                 310                 315                 320 


Ser Thr Trp Ile Phe His Gly Ser Tyr Ser Ile Leu Asn Thr Ser Ser 
                325                 330                 335     


Ser Asn Ser Leu Thr Phe Gly Asp Gly Val Leu Glu Arg Arg Pro Tyr 
            340                 345                 350         


Glu Asp Gln Gly Leu Gly Glu Thr Thr Pro Leu Thr Ile Ile Cys Gln 
        355                 360                 365             


Pro Met Gln Pro Leu Arg Val Asn Ser Gln Pro Gly Pro Gln Lys Arg 
    370                 375                 380                 


Cys Leu Phe Val Cys Arg His Gly Glu Arg Met Asp Val Val Phe Gly 
385                 390                 395                 400 


Lys Tyr Trp Leu Ser Gln Cys Phe Asp Ala Lys Gly Arg Tyr Ile Arg 
                405                 410                 415     


Thr Asn Leu Asn Met Pro His Ser Leu Pro Gln Arg Ser Gly Gly Phe 
            420                 425                 430         


Arg Asp Tyr Glu Lys Asp Ala Pro Ile Thr Val Phe Gly Cys Met Gln 
        435                 440                 445             


Ala Arg Leu Val Gly Glu Ala Leu Leu Glu Ser Asn Thr Ile Ile Asp 
    450                 455                 460                 


His Val Tyr Cys Ser Pro Ser Leu Arg Cys Val Gln Thr Ala His Asn 
465                 470                 475                 480 


Ile Leu Lys Gly Leu Gln Gln Glu Asn His Leu Lys Ile Arg Val Glu 
                485                 490                 495     


Pro Gly Leu Phe Glu Trp Thr Lys Trp Val Ala Gly Ser Thr Leu Pro 
            500                 505                 510         


Ala Trp Ile Pro Pro Ser Glu Leu Ala Ala Ala Asn Leu Ser Val Asp 
        515                 520                 525             


Thr Thr Tyr Arg Pro His Ile Pro Ile Ser Lys Leu Val Val Ser Glu 
    530                 535                 540                 


Ser Tyr Asp Thr Tyr Ile Ser Arg Ser Phe Gln Val Thr Lys Glu Ile 
545                 550                 555                 560 


Ile Ser Glu Cys Lys Ser Lys Gly Asn Asn Ile Leu Ile Val Ala His 
                565                 570                 575     


Ala Ser Ser Leu Glu Ala Cys Thr Cys Gln Leu Gln Gly Leu Ser Pro 
            580                 585                 590         


Gln Asn Ser Lys Asp Phe Val Gln Met Val Arg Lys Ile Pro Tyr Leu 
        595                 600                 605             


Gly Phe Cys Ser Cys Glu Glu Leu Gly Glu Thr Gly Ile Trp Gln Leu 
    610                 615                 620                 


Thr Asp Pro Pro Ile Leu Pro Leu Thr His Gly Pro Thr Gly Gly Phe 
625                 630                 635                 640 


Asn Trp Arg Glu Thr Leu Leu Gln Glu 
                645                 


<210>  680
<211>  3276
<212>  DNA
<213>  Homo Sapiens

<400>  680
aagtggcccg gccagcggcg cggcgtccgg ggaggaaatg gatgctgtgc tggcctgccg       60

gctccggggg cggggaaatc gagtagctgc actcaggccc cgcccgagac ccggagggag      120

cgccgggccg tccccttttg ccctcctttg cgctgggctg agcccagagc cgagagcagg      180

agtcggctct gagttccctg cttggttttt gggtggcagc agccagagga ggaatatggc      240

gctcttaggc agccgagcgg agctggaagc ggacgaggac gttttcgaag atgccttgga      300

aaccatctca atatcttctc actcagatat ggcaacaagc agccttcact ttgcatcatg      360

tgatacacaa caggcgccca gacagcgcgg agcgtctact gtcagcagtt catcatcaac      420

caaggtggat ctcaagagtg gcctcgaaga atgtgctgtg gcattgaact tatttctaag      480

caacaaattt acagacgcct tagaattgct tcgcccctgg gctaaggaga gtatgtacca      540

tgccttgggc tacagtacca ttgtggtgtt gcaggctgtc ctgaccttcg agcaacagga      600

catccagaac ggcatttctg ccatgaagga cgctttacaa acctgccaaa aatacaggaa      660

aaaatacaca gttgtagaat ctttctcaag tcttctttct agaggatccc tggagcaact      720

gagtgaagag gaaatgcatg ctgaaatctg ttatgccgag tgtctcctac agaaagctgc      780

actcacgttt gtgcaggatg aaaatatgat caacttcatc aaaggtggac tcaaaattag      840

aacaagttac caaatatata aagaatgtct ttctatcctg catgaaattc agaagaacaa      900

acttcagcag gaattcttct atgagtttga agggggtgtc aagcttggca gtggggcctt      960

taatttgatg ctgtcccttt taccagcaag gattatcaga ctactagaat ttattggatt     1020

ttctgggaat agggagttgg gcctcctgca gttacgtgaa ggtgcttcag gaaggagcat     1080

gaggtctgca ctgtgctgct taaccatctt agcttttcat acttacatct ccctaatact     1140

tggtacagga gaagtgaatg ttgcggaagc agagcgtctc ctggcaccct tcctccagca     1200

gtttccaaat ggctcactcg tgttgtttta tcatgcccga atagagttgc tgaaagggaa     1260

tcttgaagag gcacaagaag tatttcaaaa atgcatttca gttcaagaag aatggaaaca     1320

gtttcaccat ctctgctact gggagctaat gtggattaat gttttccaac aaaactggat     1380

gcaggcatat tactattcag atctgctttg caaagagagt aaatggtcca aggcaactta     1440

tgtgttcttg aaagcagcaa ttttgagtat gcttccagag gaggatgtag tagcaacgaa     1500

tgagaatgtg gtaactttat tcagacaggt ggacagcttg aagcagagaa ttgccgggaa     1560

atctatccct actgagaagt ttgctgtgag gaaggctcgg cgttactccg cctccttacc     1620

tgcacctgtg aagctcatct tacctgccct ggaaatgatg tatgtctgga atggtttttc     1680

aatagtgagc aaaagaaaag acctttctga aaatctgtta gtaactgttg aaaaagctga     1740

ggcagcttta caaagtcaaa attttaacag cttctctgtg gatgatgagt gcttagtgaa     1800

gttacttaaa ggatgttgcc tcaagaactt acagcggccc ttgcaagctg aactatgtta     1860

caatcatgtt gtggaaagtg aaaagctact gaagtatgac cactacctag tgccgttcac     1920

tctatttgaa ttggcatctt tgtataaaag ccagggggaa attgacaagg ccataaagtt     1980

cctagaaact gcaaggaaca actacaaaga ttactccctg gagtccagac tacacttcag     2040

aattcaggca gctcttcacc tctggagaaa accttcctca gattgatcag aacttgaagg     2100

atggaatttt tcctcaatta gcatcggcat ctgctataga ttcaacctta tattaaagtg     2160

gaaaaatgat cttgtgaata agagacaaaa aaacagtttt tttggtcaat attttctatc     2220

atctgagaga tttactgttg gtctacataa ttttttttcc tatggaatgg cattctatat     2280

tatctagaaa attcttatat tttgcctccc ccaaaagaat ttcatattat ttgaattagg     2340

gggcgaagaa gtcttttgaa agacttgcag atgcaatagt ctaattagat tatttatttt     2400

tttaatgtga aaattaatat tgtttagcaa atagcttaca agttgagcca attttggatt     2460

tgttgggtag ttaaacttca gagatatttt gttgcctgta tttaaatttc agaagataaa     2520

taaatatcat tgcatttaaa atagcttaac agtgaccttc agaagacttc tgaaaaagac     2580

agtctgagaa catgaacacg gatcgatata atgtacttca tgggttgaag agacctttct     2640

ctataaagga tgatgcagta ttcagttagt ggttttttac tcttcatttg attaaaggtg     2700

gtgacgtttt ggagagactg attttgaatg tacttaagtc tattataata acaaaattca     2760

aaacccctgt gtatctaaag ggaaggaagt gtcatatttt aggaattttt cttaacctta     2820

gcaatgagag cctaaaatac atacatggat tatttttctt ctaggaagta aatttcctgc     2880

tgctttaaat gatatgtaaa atatcaataa tttttacact taagatgttg gtaagaccta     2940

gttttctaat ctctctagca ctgtgatgtc tccttgtaga taatctggac cttgcttagt     3000

cctttagttg ggaaacagaa tcagggcata gagcagaaga gagcttgaca ctccatatgg     3060

tcctggttct gctacccatt agcgattagt gaggagacct ttagggagtc cactgtgccc     3120

tgtgtgtcac cacattttct tctgtgaaat caagattaaa gaacagatga ctttcaaggt     3180

ctttttcagt tttataactg tgagtctatg tattaggtat ttattttcaa caaatgactt     3240

taaaatgtcg aatgcaaacc aaaaaaaaaa aaaaaa                               3276


<210>  681
<211>  682
<212>  PRT
<213>  Homo Sapiens

<400>  681

Met Asp Ala Val Leu Ala Cys Arg Leu Arg Gly Arg Gly Asn Arg Val 
1               5                   10                  15      


Ala Ala Leu Arg Pro Arg Pro Arg Pro Gly Gly Ser Ala Gly Pro Ser 
            20                  25                  30          


Pro Phe Ala Leu Leu Cys Ala Gly Leu Ser Pro Glu Pro Arg Ala Gly 
        35                  40                  45              


Val Gly Ser Glu Phe Pro Ala Trp Phe Leu Gly Gly Ser Ser Gln Arg 
    50                  55                  60                  


Arg Asn Met Ala Leu Leu Gly Ser Arg Ala Glu Leu Glu Ala Asp Glu 
65                  70                  75                  80  


Asp Val Phe Glu Asp Ala Leu Glu Thr Ile Ser Ile Ser Ser His Ser 
                85                  90                  95      


Asp Met Ala Thr Ser Ser Leu His Phe Ala Ser Cys Asp Thr Gln Gln 
            100                 105                 110         


Ala Pro Arg Gln Arg Gly Ala Ser Thr Val Ser Ser Ser Ser Ser Thr 
        115                 120                 125             


Lys Val Asp Leu Lys Ser Gly Leu Glu Glu Cys Ala Val Ala Leu Asn 
    130                 135                 140                 


Leu Phe Leu Ser Asn Lys Phe Thr Asp Ala Leu Glu Leu Leu Arg Pro 
145                 150                 155                 160 


Trp Ala Lys Glu Ser Met Tyr His Ala Leu Gly Tyr Ser Thr Ile Val 
                165                 170                 175     


Val Leu Gln Ala Val Leu Thr Phe Glu Gln Gln Asp Ile Gln Asn Gly 
            180                 185                 190         


Ile Ser Ala Met Lys Asp Ala Leu Gln Thr Cys Gln Lys Tyr Arg Lys 
        195                 200                 205             


Lys Tyr Thr Val Val Glu Ser Phe Ser Ser Leu Leu Ser Arg Gly Ser 
    210                 215                 220                 


Leu Glu Gln Leu Ser Glu Glu Glu Met His Ala Glu Ile Cys Tyr Ala 
225                 230                 235                 240 


Glu Cys Leu Leu Gln Lys Ala Ala Leu Thr Phe Val Gln Asp Glu Asn 
                245                 250                 255     


Met Ile Asn Phe Ile Lys Gly Gly Leu Lys Ile Arg Thr Ser Tyr Gln 
            260                 265                 270         


Ile Tyr Lys Glu Cys Leu Ser Ile Leu His Glu Ile Gln Lys Asn Lys 
        275                 280                 285             


Leu Gln Gln Glu Phe Phe Tyr Glu Phe Glu Gly Gly Val Lys Leu Gly 
    290                 295                 300                 


Ser Gly Ala Phe Asn Leu Met Leu Ser Leu Leu Pro Ala Arg Ile Ile 
305                 310                 315                 320 


Arg Leu Leu Glu Phe Ile Gly Phe Ser Gly Asn Arg Glu Leu Gly Leu 
                325                 330                 335     


Leu Gln Leu Arg Glu Gly Ala Ser Gly Arg Ser Met Arg Ser Ala Leu 
            340                 345                 350         


Cys Cys Leu Thr Ile Leu Ala Phe His Thr Tyr Ile Ser Leu Ile Leu 
        355                 360                 365             


Gly Thr Gly Glu Val Asn Val Ala Glu Ala Glu Arg Leu Leu Ala Pro 
    370                 375                 380                 


Phe Leu Gln Gln Phe Pro Asn Gly Ser Leu Val Leu Phe Tyr His Ala 
385                 390                 395                 400 


Arg Ile Glu Leu Leu Lys Gly Asn Leu Glu Glu Ala Gln Glu Val Phe 
                405                 410                 415     


Gln Lys Cys Ile Ser Val Gln Glu Glu Trp Lys Gln Phe His His Leu 
            420                 425                 430         


Cys Tyr Trp Glu Leu Met Trp Ile Asn Val Phe Gln Gln Asn Trp Met 
        435                 440                 445             


Gln Ala Tyr Tyr Tyr Ser Asp Leu Leu Cys Lys Glu Ser Lys Trp Ser 
    450                 455                 460                 


Lys Ala Thr Tyr Val Phe Leu Lys Ala Ala Ile Leu Ser Met Leu Pro 
465                 470                 475                 480 


Glu Glu Asp Val Val Ala Thr Asn Glu Asn Val Val Thr Leu Phe Arg 
                485                 490                 495     


Gln Val Asp Ser Leu Lys Gln Arg Ile Ala Gly Lys Ser Ile Pro Thr 
            500                 505                 510         


Glu Lys Phe Ala Val Arg Lys Ala Arg Arg Tyr Ser Ala Ser Leu Pro 
        515                 520                 525             


Ala Pro Val Lys Leu Ile Leu Pro Ala Leu Glu Met Met Tyr Val Trp 
    530                 535                 540                 


Asn Gly Phe Ser Ile Val Ser Lys Arg Lys Asp Leu Ser Glu Asn Leu 
545                 550                 555                 560 


Leu Val Thr Val Glu Lys Ala Glu Ala Ala Leu Gln Ser Gln Asn Phe 
                565                 570                 575     


Asn Ser Phe Ser Val Asp Asp Glu Cys Leu Val Lys Leu Leu Lys Gly 
            580                 585                 590         


Cys Cys Leu Lys Asn Leu Gln Arg Pro Leu Gln Ala Glu Leu Cys Tyr 
        595                 600                 605             


Asn His Val Val Glu Ser Glu Lys Leu Leu Lys Tyr Asp His Tyr Leu 
    610                 615                 620                 


Val Pro Phe Thr Leu Phe Glu Leu Ala Ser Leu Tyr Lys Ser Gln Gly 
625                 630                 635                 640 


Glu Ile Asp Lys Ala Ile Lys Phe Leu Glu Thr Ala Arg Asn Asn Tyr 
                645                 650                 655     


Lys Asp Tyr Ser Leu Glu Ser Arg Leu His Phe Arg Ile Gln Ala Ala 
            660                 665                 670         


Leu His Leu Trp Arg Lys Pro Ser Ser Asp 
        675                 680         


<210>  682
<211>  3937
<212>  DNA
<213>  Homo Sapiens

<400>  682
ataagttagc gccgctctcc gcctcggcag tgccagccgc cagtggtcgc acttggaggg       60

tctcgccgcc agtggaagga gccaccgccc ccgcccgacc atggccgagg agctggtctt      120

agagaggtgt gatctggagc tggagaccaa tggccgagac caccacacgg ccgacctgtg      180

ccgggagaag ctggtggtgc gacggggcca gcccttctgg ctgaccctgc actttgaggg      240

ccgcaactac gaggccagtg tagacagtct caccttcagt gtcgtgaccg gcccagcccc      300

tagccaggag gccgggacca aggcccgttt tccactaaga gatgctgtgg aggagggtga      360

ctggacagcc accgtggtgg accagcaaga ctgcaccctc tcgctgcagc tcaccacccc      420

ggccaacgcc cccatcggcc tgtatcgcct cagcctggag gcctccactg gctaccaggg      480

atccagcttt gtgctgggcc acttcatttt gctcttcaac gcctggtgcc cagcggatgc      540

tgtgtacctg gactcggaag aggagcggca ggagtatgtc ctcacccagc agggctttat      600

ctaccagggc tcggccaagt tcatcaagaa cataccttgg aattttgggc agtttgaaga      660

tgggatccta gacatctgcc tgatccttct agatgtcaac cccaagttcc tgaagaacgc      720

cggccgtgac tgctcccgcc gcagcagccc cgtctacgtg ggccgggtgg tgagtggcat      780

ggtcaactgc aacgatgacc agggtgtgct gctgggacgc tgggacaaca actacgggga      840

cggcgtcagc cccatgtcct ggatcggcag cgtggacatc ctgcggcgct ggaagaacca      900

cggctgccag cgcgtcaagt atggccagtg ctgggtcttc gccgccgtgg cctgcacagt      960

gctgaggtgc ctgggcatcc ctacccgcgt cgtgaccaac tacaactcgg cccatgacca     1020

gaacagcaac cttctcatcg agtacttccg caatgagttt ggggagatcc agggtgacaa     1080

gagcgagatg atctggaact tccactgctg ggtggagtcg tggatgacca ggccggacct     1140

gcagccgggg tacgagggct ggcaggccct ggacccaacg ccccaggaga agagcgaagg     1200

gacgtactgc tgtggcccag ttccagttcg tgccatcaag gagggcgacc tgagcaccaa     1260

gtacgatgcg ccctttgtct ttgcggaggt caatgccgac gtggtagact ggatccagca     1320

ggacgatggg tctgtgcaca aatccatcaa ccgttccctg atcgttgggc tgaagatcag     1380

cactaagagc gtgggccgag acgagcggga ggatatcacc cacacctaca aatacccaga     1440

ggggtcctca gaggagaggg aggccttcac aagggcgaac cacctgaaca aactggccga     1500

gaaggaggag acagggatgg ccatgcggat ccgtgtgggc cagagcatga acatgggcag     1560

tgactttgac gtctttgccc acatcaccaa caacaccgct gaggagtacg tctgccgcct     1620

cctgctctgt gcccgcaccg tcagctacaa tgggatcttg gggcccgagt gtggcaccaa     1680

gtacctgctc aacctcaacc tggagccttt ctctgagaag agcgttcctc tttgcatcct     1740

ctatgagaaa taccgtgact gccttacgga gtccaacctc atcaaggtgc gggccctcct     1800

cgtggagcca gttatcaaca gctacctgct ggctgagagg gacctctacc tggagaatcc     1860

agaaatcaag atccggatcc ttggggagcc caagcagaaa cgcaagctgg tggctgaggt     1920

gtccctgcag aacccgctcc ctgtggccct ggaaggctgc accttcactg tggagggggc     1980

cggcctgact gaggagcaga agacggtgga gatcccagac cccgtggagg caggggagga     2040

agttaaggtg agaatggacc tgctgccgct ccacatgggc ctccacaagc tggtggtgaa     2100

cttcgagagc gacaagctga aggctgtgaa gggcttccgg aatgtcatca ttggccccgc     2160

ctaagggacc cctgctccca gcctgctgag agcccccacc ttgatcccaa tccttatccc     2220

aagctagtga gcaaaatatg ccccttcttg ggccccagac cccagggcag ggtgggcagc     2280

ctatgggggc tctcggaaat ggaatgtgcc cctggcccat ctcagcctcc tgagcctgtg     2340

ggtccccact cacccccttt gctgtgagga atgctctgtg ccagaaacag tgggagccct     2400

gaccttggct gactggggct ggggtgagag aggaaagacc tacattccct ctcctgccca     2460

gatgcccttt ggaaagccat tgaccaccca ccatattgtt tgatctactt catagctcct     2520

tggagcaggc aaaaaaggga cagcatgccc cttggctgga tcagggaatc cagctcccta     2580

gactgcatcc cgtacctctt cccatgactg cacccagctc caggggccct tgggacagcc     2640

agagctgggt ggggacagtg ataggcccaa ggtcccctcc acatcccagc agcccaagct     2700

taatagccct ccccctcaac ctcaccattg tgaagcacct actatgtgct gggtgcctcc     2760

cacacttgct ggggctcacg gggcctccaa cccatttaat caccatggga aactgttgtg     2820

ggcgctgctt ccaggataag gagactgagg cttagagaga ggaggcagcc ccctccacac     2880

cagtggcctc gtggttatta gcaaggctgg gtaatgtgaa ggcccaagag cagagtctgg     2940

gcctctgact ctgagtccac tgctccattt ataaccccag cctgacctga gactgtcgga     3000

gaggctgtct ggggccttta tcaaaaaaag actcagccaa gacaaggagg tagagagggg     3060

actgggggac tgggagtcag agccctggct gggttcaggt cccacgtctg gccaggcact     3120

gccttctcct ctctgggcct ttgtttcctt gttggtcaga ggagtgattg aaccagctca     3180

tctccaagga tcctctccac tccatgtttg caatgctttt atatggccca gccttgtaaa     3240

taaccacaag gtccactccc tgctccacga agccttaagc cataggccca ggatatttct     3300

gagagtgaaa ccatgactgt gaccaccttc tgtccccagc cctgtcctgg ttccttccta     3360

tgcccaggta ccacccttca gaccccagtt ctaggggaga agagccctgg acacccctgc     3420

tctacccatg agcctgcccg ctgcaatgcc tagacttccc aacagcctta gctgccagtg     3480

ctggtcacta accaacaagg ttggcacccc agctacccct tctttgcagg gctaaggccc     3540

ccaaacatag cccctgcccc ggaggaagct tggggaaccc atgagttgtc agctttgact     3600

ttatctcctg ctctttctac atgactgggc ctcccttggg ctggaagaat tggggattct     3660

ctattggagg tgagatcaca gcctccaggg ccccccaaat cccagggaag gacttggaga     3720

gaatcatgct gttgcattta gaactttctg ctttgcacag gaaagagtca cacaattaat     3780

caacatgtat attttctcta tacatagagc tctatttctc tacggtttta taaaagcctt     3840

gggttccaac caggcagtag atgtgcttct gaaccgcaag gagcaaacac tgaaataaaa     3900

tagtttattt ttcacactca aaaaaaaaaa aaaaaaa                              3937


<210>  683
<211>  687
<212>  PRT
<213>  Homo Sapiens

<400>  683

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210>  684
<211>  3950
<212>  DNA
<213>  Homo Sapiens

<400>  684
attgcgtccc gctctacctc tgtggttctt tgggagcgac ccccgggaag cgtccaaagt       60

ggagttccca cacacgctgc gaacccacag ccggttttct ctgaactcgc gtccctgagt      120

ccgggaggtg gaggcggaga aaagggtgcg gagcgacccc acgcagggcc gccccccctc      180

ccaccagcgc gtcctgccgc gccggcagcc acaggctggc atagcggctg ccgacccgcc      240

ctcgttcctc caccccctga acgggactgc tgggcccgcc ccgccccgcc tgcaggtgaa      300

gcggccgcag ccgccgagta ggtgcgtggg gatgatctca ctcgcgcgct ccgcgccagg      360

aggaggagga gcgggagcgg atccaacttc cgggtagtgg agccgcaagc caccggcatc      420

ttgctttttc ttccccctcc tcctgtgtgc cccgcgccgc tccctctttc ccttttattc      480

ccggccccac ccgccaaaat gaacagctcg gacgaagaga agcagctgca gctcattacc      540

agtctgaagg agcaagcaat aggcgaatat gaagacctta gagcagagaa ccagaaaaca      600

aaggagaagt gtgacaaaat taggcaagaa cgagatgaag ccgttaaaaa actggaagaa      660

tttcagaaaa tttctcacat ggtcatagag gaagttaatt tcatgcagaa ccatcttgaa      720

atagagaaga cttgtcgaga aagtgctgaa gctttggcaa caaagctaaa taaagaaaat      780

aaaacgttga aaagaatcag catgttgtac atggccaagc tgggaccaga tgtaataact      840

gaagagataa acattgatga tgaagattcg actacagaca cagacggtgc cgccgagact      900

tgtgtctcag tacagtgtca gaagcaaatt aaagaacttc gagatcaaat tgtatctgtt      960

caggaggaaa agaagatttt agccattgag ctggaaaatc tcaagagcaa actcgtagaa     1020

gtaattgaag aagtaaataa agttaaacaa gaaaagactg ttttaaattc agaagttctt     1080

gaacagagaa aagtcttaga aaaatgcaat agagtgtcca tgttagctgt agaagagtat     1140

gaggagatgc aagtaaacct ggagctggag aaggaccttc gaaagaaagc agagtcattt     1200

gcacaagaga tgttcattga gcaaaacaag ctaaagagac aaagccacct tctgctgcag     1260

agctccatcc ctgatcagca gcttttgaaa gctttagacg aaaatgcaaa actcacccag     1320

caacttgaag aagagagaat tcagcatcaa caaaaggtca aagaattaga agagcaacta     1380

gaaaatgaaa cactccacaa agaaatacac aacctcaaac agcaactgga gcttctagag     1440

gaagataaaa aggaattgga attgaaatat cagaattctg aagagaaagc cagaaattta     1500

aagcactctg ttgatgaact ccagaaacga gtgaaccagt ctgagaattc agtacctcca     1560

ccacctcctc ctccaccacc acttccccct ccacctccca atcctatccg atccctcatg     1620

tccatgatcc ggaaacgatc ccaccccagt ggcagtggtg ctaagaaaga aaaggcaact     1680

caaccagaaa caactgaaga agtcacagat ctaaagaggc aagcagttga agagatgatg     1740

gatagaatta aaaagggagt tcatcttaga cccgttaatc agacagccag accgaagaca     1800

aagccagaat cttcgaaagg ctgcgaaagt gcagtggatg aactaaaagg aatactgggg     1860

acacttaaca aatccactag ttcaagaagc ttaaaatccc ttgaccctga aaacagtgaa     1920

actgagttag aaaggatttt gcgtcgcaga aaggtgacag cagaagcaga tagcagtagt     1980

ccaactggga tattagccac ctcagagtcc aaatccatgc cagtgttggg ttctgtatcc     2040

agtgtaacaa aaacagcctt gaacaagaaa actctggagg cagaattcaa cagcccgtcc     2100

cccccaacac ctgagccagg tgaagggccc cgtaaattgg aaggatgcac aagttccaag     2160

gttacgtttc agcctcccag tagcattgga tgcaggaaaa aatacattga cggtgaaaaa     2220

caagccgaac cagttgtagt tttagatcct gtttctacac atgaacccca aaccaaagac     2280

caggttgctg aaaaagatcc aactcaacac aaggaggatg aaggcgaaat tcaaccagaa     2340

aacaaagaag acagcattga aaacgtgaga gagacagaca gctccaactg ctgatccata     2400

aaccagaagc ctgacatgtt tggaagtcct tttcaataag cacatgatta gtgttgttat     2460

attggcaagg gctgtagaca ttctgctctg gtcactgtat tcagaataca ggttcttttc     2520

tggtgtcact tttgtaagta gcaactataa acataagtaa gctgtttagc aaaacacaca     2580

ttcctagtag gttttggttt tttgatcttt ataaagatga ggtttttttc ctagttactg     2640

tattaagtat gacttctttt agaaggttac aaaaaaattc agatgttgat acctttttag     2700

gaaatgtgca taccactcat caaatggaat gctgaaagtt tgaggtgctt gtatataatc     2760

ggataaacaa aactgatcaa cccaatgtga ttttaaaagc ccccaaagaa gcttctgttt     2820

tgggtctgat cctcttgatg gagaaactgc agcagcatgg aaattgttgg gtactgtggc     2880

atacaagtta ttttctacag tagactgaga taaactgaaa actcaggagc tggcatcaaa     2940

ctcgtagtcc catagtcagt gttaattaca cacattgtta actattggat gaaaaataca     3000

tgctattgat tgtgtccaaa gcctcccgag gacctccgtg gggatgctct ggtagcctga     3060

atacagaact gaggtgaaag tccaaacctt gaattttaca gtagtaagtt ggtaaaccat     3120

gtgctctgtg ctatgagtta attatgtttt cccaaatact aatgtggcac aagtaccata     3180

ttttatcaga gttcttatgt acagtatggt gaagataagt gacaagcaca catttttctt     3240

gcttcactgc tgttctatat tacacaggtt tgttgttgtt ttttttaaaa aagaaattaa     3300

gcagtagtta gtctctaaaa atacaatgtt tcaggctacc acagtgaata aatagaaatg     3360

taatcaggga ttaaaaaaaa aacttatgca gcttttcaaa gttgattgtt tcaaaattgg     3420

tgtttattta aaataagtgg taatgtactt gaatgcactt tttatgacaa tgattcagta     3480

atggtaattt tactattaaa gaaagtgaaa ggtttagttt tgttagcatg gctcagcatg     3540

tagctgtcag gtgtttttca cctaagggca aaagaaaatg atagtaataa ttgcagtagt     3600

tgtattgtat tgtatttttg cacgtgtggt aagcataggc ttgaagaggt gggtaggcag     3660

gtacatgtac ttcctaaatt tggagataat tatctttctg taagttcgtt atgcttgact     3720

gtttccatgt tctcccaata atgattttat agttacttat cactttactc atggagaatt     3780

aaaacgtaat gtttttcaac tgtatctttc tttaactgga taatactgct atatgatatg     3840

cttactacag actgcattaa ttcacgaaac gaattctgtt atgctgtaat ttgaactctc     3900

ctcaccacaa cttattaaaa aggcaccaat agtttcccat taaaaaaaaa                3950


<210>  685
<211>  631
<212>  PRT
<213>  Homo Sapiens

<400>  685

Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Gly Thr Leu Asn Lys Ser Thr Ser Ser Arg Ser 
    450                 455                 460                 


Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu Leu Glu Arg Ile 
465                 470                 475                 480 


Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser Ser Ser Pro Thr 
                485                 490                 495     


Gly Ile Leu Ala Thr Ser Glu Ser Lys Ser Met Pro Val Leu Gly Ser 
            500                 505                 510         


Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys Thr Leu Glu Ala 
        515                 520                 525             


Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro Gly Glu Gly Pro 
    530                 535                 540                 


Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr Phe Gln Pro Pro 
545                 550                 555                 560 


Ser Ser Ile Gly Cys Arg Lys Lys Tyr Ile Asp Gly Glu Lys Gln Ala 
                565                 570                 575     


Glu Pro Val Val Val Leu Asp Pro Val Ser Thr His Glu Pro Gln Thr 
            580                 585                 590         


Lys Asp Gln Val Ala Glu Lys Asp Pro Thr Gln His Lys Glu Asp Glu 
        595                 600                 605             


Gly Glu Ile Gln Pro Glu Asn Lys Glu Asp Ser Ile Glu Asn Val Arg 
    610                 615                 620                 


Glu Thr Asp Ser Ser Asn Cys 
625                 630     


<210>  686
<211>  1917
<212>  DNA
<213>  Homo Sapiens

<400>  686
aatatcttgc atgttacaga tttcactact cccaccagct tggagacaac atgtggttct       60

tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca aaggcagtga      120

tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc ttgcactgtg      180

aggtgctcca tctgcctggg agcagctcca cacagtggtt tctcaatggc acagccactc      240

agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt ggtgaataca      300

ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc cacagaggct      360

ggctactact gcaggtctcc agcagagtct tcatggaagg agaacctctg gccttgaggt      420

gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat ggcaaagcct      480

ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata agtcacaatg      540

gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga atatcacaat      600

acactgtgaa aggcctccag ttaccaactc ctgtctggtt tcatgtcctt ttctatctgg      660

cagtgggaat aatgttttta gtgaacactg ttctctgggt gacaatacgt aaagaactga      720

aaagaaagaa aaagtggaat ttagaaatct ctttggattc tggtcatgag aagaaggtaa      780

tttccagcct tcaagaagac agacatttag aagaagagct gaaatgtcag gaacaaaaag      840

aagaacagct gcaggaaggg gtgcaccgga aggagcccca gggggccacg tagcagcggc      900

tcagttggtg gccatcgatc tggaccgtcc cctgcccact tgctccccgt gagcactgcg      960

tacaaacatc caaaagttca acaacaccag aactgtgtgt ctcatggtat ataactctta     1020

aagcaaataa atgaactgac ttcaactggg atacatttgg aaatgtggtc atcaaagatg     1080

acttgaaatg aggcctactc taaagaattc ttgaaaaact tacaagtcaa gcctagcctg     1140

ataatcctat tacatagttt gaaaaatagt attttatttc tcagaacaag gtaaaaaggt     1200

gagtgggtgc atatgtacag aagattaaga cagagaaaca gacagaaaga gacacacaca     1260

cagccaggag tgggtagatt tcagggagac aagagggaat agtatagaca ataaggaagg     1320

aaatagtact tacaaatgac tcctaaggga ctgtgagact gagagggctc acgcctctgt     1380

gttcaggata cttagttcat ggcttttctc tttgacttta ctaaaagaga atgtctccat     1440

acgcgttcta ggcatacaag ggggtaactc atgatgagaa atggatgtgt tattcttgcc     1500

ctctcttttg aggctctctc ataacccctc tatttctaga gacaacaaaa atgttgccag     1560

tcctaggccc ctgccctgta ggaaggcaga atgtaactgt tctttttgtt taacgattaa     1620

gtccaaatct ccaagtgcgg cactgcaaag agacgcttca agtggggaga agcggcgata     1680

tcatagagtc cagatcttgc ctccagagat ttgctttacc ttcctgattt tctggttact     1740

aattagcttc aggatacgct gctctcatac ttgggctgta gtttggagac aaaatatttt     1800

cctgccactg tgtaacatag ctgaggtaaa aactgaacta tgtaaatgac tctactaaaa     1860

gtttagggaa aaaaaacagg aggagtatga cacacacagc aaaaaaaaaa aaaaaaa        1917


<210>  687
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  687

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Met Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Gln Tyr Thr Val Lys Gly Leu Gln Leu Pro 
            180                 185                 190         


Thr Pro Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met 
        195                 200                 205             


Phe Leu Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys 
    210                 215                 220                 


Arg Lys Lys Lys Trp Asn Leu Glu Ile Ser Leu Asp Ser Gly His Glu 
225                 230                 235                 240 


Lys Lys Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu 
                245                 250                 255     


Leu Lys Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His 
            260                 265                 270         


Arg Lys Glu Pro Gln Gly Ala Thr 
        275                 280 


<210>  688
<211>  2076
<212>  DNA
<213>  Homo Sapiens

<400>  688
attggctgcc gcgcggggcg gggagcgggg tcggctcagt ggccctgaga ccctagctct       60

gctctcggtc cgctcgctgt ccgctagccc gctgcgatgt tgcgcgctgc cgcccgcttc      120

gggccccgcc tgggccgccg cctcttgtca gccgccgcca cccaggccgt gcctgccccc      180

aaccagcagc ccgaggtctt ctgcaaccag attttcataa acaatgaatg gcacgatgcc      240

gtcagcagga aaacattccc caccgtcaat ccgtccactg gagaggtcat ctgtcaggta      300

gctgaagggg acaaggaaga tgtggacaag gcagtgaagg ccgcccgggc cgccttccag      360

ctgggctcac cttggcgccg catggacgca tcacacaggg gccggctgct gaaccgcctg      420

gccgatctga tcgagcggga ccggacctac ctggcggcct tggagaccct ggacaatggc      480

aagccctatg tcatctccta cctggtggat ttggacatgg tcctcaaatg tctccggtat      540

tatgccggct gggctgataa gtaccacggg aaaaccatcc ccattgacgg agacttcttc      600

agctacacac gccatgaacc tgtgggggtg tgcgggcaga tcattccgtg gaatttcccg      660

ctcctgatgc aagcatggaa gctgggccca gccttggcaa ctggaaacgt ggttgtgatg      720

aaggtagctg agcagacacc cctcaccgcc ctctatgtgg ccaacctgat caaggaggct      780

ggctttcccc ctggtgtggt caacattgtg cctggatttg gccccacggc tggggccgcc      840

attgcctccc atgaggatgt ggacaaagtg gcattcacag gctccactga gattggccgc      900

gtaatccagg ttgctgctgg gagcagcaac ctcaagagag tgaccttgga gctggggggg      960

aagagcccca acatcatcat gtcagatgcc gatatggatt gggccgtgga acaggcccac     1020

ttcgccctgt tcttcaacca gggccagtgc tgctgtgccg gctcccggac cttcgtgcag     1080

gaggacatct atgatgagtt tgtggagcgg agcgttgccc gggccaagtc tcgggtggtc     1140

gggaacccct ttgatagcaa gaccgagcag gggccgcagg tggatgaaac tcagtttaag     1200

aagatcctcg gctacatcaa cacggggaag caagaggggg cgaagctgct gtgtggtggg     1260

ggcattgctg ctgaccgtgg ttacttcatc cagcccactg tgtttggaga tgtgcaggat     1320

ggcatgacca tcgccaagga ggagatcttc gggccagtga tgcagatcct gaagttcaag     1380

accatagagg aggttgttgg gagagccaac aattccacgt acgggctggc cgcagctgtc     1440

ttcacaaagg atttggacaa ggccaattac ctgtcccagg ccctccaggc gggcactgtg     1500

tgggtcaact gctatgatgt gtttggagcc cagtcaccct ttggtggcta caagatgtcg     1560

gggagtggcc gggagttggg cgagtacggg ctgcaggcat acactgaagt gaaaactgtc     1620

acagtcaaag tgcctcagaa gaactcataa gaatcatgca agcttcctcc ctcagccatt     1680

gatggaaagt tcagcaagat cagcaacaaa accaagaaaa atgatccttg cgtgctgaat     1740

atctgaaaag agaaattttt cctacaaaat ctcttgggtc aagaaagttc tagaatttga     1800

attgataaac atggtgggtt ggctgagggt aagagtatat gaggaacctt ttaaacgaca     1860

acaatactgc tagctttcag gatgattttt aaaaaataga ttcaaatgtg ttatcctctc     1920

tctgaaacgc ttcctataac tcgagtttat aggggaagaa aaagctattg tttacaatta     1980

tatcaccatt aaggcaactg ctacaccctg ctttgtattc tgggctaaga ttcattaaaa     2040

actagctgct cttaacttac aaaaaaaaaa aaaaaa                               2076


<210>  689
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  689

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
1               5                   10                  15      


Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro 
            20                  25                  30          


Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala 
        35                  40                  45              


Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val 
    50                  55                  60                  


Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
65                  70                  75                  80  


Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met 
                85                  90                  95      


Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile 
            100                 105                 110         


Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly 
        115                 120                 125             


Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys 
    130                 135                 140                 


Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr 
145                 150                 155                 160 


Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val 
                165                 170                 175     


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln 
            180                 185                 190         


Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met 
        195                 200                 205             


Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu 
    210                 215                 220                 


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
225                 230                 235                 240 


Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp 
                245                 250                 255     


Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val 
            260                 265                 270         


Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
        275                 280                 285             


Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val 
    290                 295                 300                 


Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys 
305                 310                 315                 320 


Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val 
                325                 330                 335     


Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe 
            340                 345                 350         


Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys 
        355                 360                 365             


Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu 
    370                 375                 380                 


Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro 
385                 390                 395                 400 


Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu 
                405                 410                 415     


Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu 
            420                 425                 430         


Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val 
        435                 440                 445             


Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln 
    450                 455                 460                 


Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser 
465                 470                 475                 480 


Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu 
                485                 490                 495     


Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val 
            500                 505                 510         


Pro Gln Lys Asn Ser 
        515         


<210>  690
<211>  1180
<212>  DNA
<213>  Homo Sapiens

<400>  690
ggaggggcgg ggcggacgca gagccgcgtt tagtctatcg ctgcggttgc gagcgctgta       60

gggagcctgt gctgtgccgc gcagttaggc agcagcagcc gcggagcagt agccgccgtg      120

ggagggagcc atgaagcatt acgaggtgga gattctggac gcaaagacaa gggagaagct      180

gtgtttcttg gacaaggtgg agccccacgc caccattgcg gagatcaaga acctcttcac      240

taagacccat ccgcagtggt accccgcccg ccagtccctc cgcctggacc ccaagggcaa      300

gtccctgaag gatgaggatg ttctgcagaa gctgcccgtg ggcaccacgg ccacactgta      360

cttccgggac ctgggggccc agatcagctg ggtgacggtc ttcctaacag agtacgcggg      420

gccccttttc atctacctgc tcttctactt ccgagtgccc ttcatctatg gccacaaata      480

tgactttacg tccagtcggc atacagtggt gcacctcgcc tgcatctgtc actcattcca      540

ctacatcaag cgcctgctgg agacgctctt cgtgcaccgc ttctcccatg gcactatgcc      600

tttgcgcaac atcttcaaga actgcaccta ctactggggc ttcgccgcgt ggatggccta      660

ttacatcaat caccctctct acactccccc tacctacgga gctcagcagg tgaaactggc      720

gctcgccatc tttgtgatct gccagctcgg caacttctcc atccacatgg ccctgcggga      780

cctgcggccc gctgggtcca agacgcggaa gatcccatac cccaccaaga accccttcac      840

gtggctcttc ctgctggtgt cctgccccaa ctacacctac gaggtggggt cctggatcgg      900

tttcgccatc atgacgcagt gtctcccagt ggccctgttc tccctggtgg gcttcaccca      960

gatgaccatc tgggccaagg gcaagcaccg cagctacctg aaggagttcc gggactaccc     1020

gcccctgcgc atgcccatca tccccttcct gctctgagcg ctcacccctg ctgaggctca     1080

gcccctcaac ccggtggcat tctgggggag gagtggggcc cacagctctc cagcacccgg     1140

aataaagccc gcctgcccca gtcggaaaaa aaaaaaaaaa                           1180


<210>  691
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  691

Met Lys His Tyr Glu Val Glu Ile Leu Asp Ala Lys Thr Arg Glu Lys 
1               5                   10                  15      


Leu Cys Phe Leu Asp Lys Val Glu Pro His Ala Thr Ile Ala Glu Ile 
            20                  25                  30          


Lys Asn Leu Phe Thr Lys Thr His Pro Gln Trp Tyr Pro Ala Arg Gln 
        35                  40                  45              


Ser Leu Arg Leu Asp Pro Lys Gly Lys Ser Leu Lys Asp Glu Asp Val 
    50                  55                  60                  


Leu Gln Lys Leu Pro Val Gly Thr Thr Ala Thr Leu Tyr Phe Arg Asp 
65                  70                  75                  80  


Leu Gly Ala Gln Ile Ser Trp Val Thr Val Phe Leu Thr Glu Tyr Ala 
                85                  90                  95      


Gly Pro Leu Phe Ile Tyr Leu Leu Phe Tyr Phe Arg Val Pro Phe Ile 
            100                 105                 110         


Tyr Gly His Lys Tyr Asp Phe Thr Ser Ser Arg His Thr Val Val His 
        115                 120                 125             


Leu Ala Cys Ile Cys His Ser Phe His Tyr Ile Lys Arg Leu Leu Glu 
    130                 135                 140                 


Thr Leu Phe Val His Arg Phe Ser His Gly Thr Met Pro Leu Arg Asn 
145                 150                 155                 160 


Ile Phe Lys Asn Cys Thr Tyr Tyr Trp Gly Phe Ala Ala Trp Met Ala 
                165                 170                 175     


Tyr Tyr Ile Asn His Pro Leu Tyr Thr Pro Pro Thr Tyr Gly Ala Gln 
            180                 185                 190         


Gln Val Lys Leu Ala Leu Ala Ile Phe Val Ile Cys Gln Leu Gly Asn 
        195                 200                 205             


Phe Ser Ile His Met Ala Leu Arg Asp Leu Arg Pro Ala Gly Ser Lys 
    210                 215                 220                 


Thr Arg Lys Ile Pro Tyr Pro Thr Lys Asn Pro Phe Thr Trp Leu Phe 
225                 230                 235                 240 


Leu Leu Val Ser Cys Pro Asn Tyr Thr Tyr Glu Val Gly Ser Trp Ile 
                245                 250                 255     


Gly Phe Ala Ile Met Thr Gln Cys Leu Pro Val Ala Leu Phe Ser Leu 
            260                 265                 270         


Val Gly Phe Thr Gln Met Thr Ile Trp Ala Lys Gly Lys His Arg Ser 
        275                 280                 285             


Tyr Leu Lys Glu Phe Arg Asp Tyr Pro Pro Leu Arg Met Pro Ile Ile 
    290                 295                 300                 


Pro Phe Leu Leu 
305             


<210>  692
<211>  2242
<212>  DNA
<213>  Homo Sapiens

<400>  692
gaatctcgac ccttgaatgg agttacacga acggccagat gaaagaagga aggcccggac       60

ctccactcag ggccgactag gggactggcg gagggtgcac gctgatggat ttactcaccg      120

ggtgcttgga gctccagcag ctggctggag cccgcgatga cgtcacggac tcgggtcaca      180

tggccaagtc cgccccgccc cctccccgtc cccgccgctg cagcggtcgc cttcggagcg      240

aagggtaccg acccggcaga agctcggagc tctcggggta tcgaggaggc aggcccgcgg      300

gcgcacgggc gagcgggccg ggagccggag cggcggagga gccggcagca gcggcgcggc      360

gggctccagg cgaggcggtc gacgctcctg aaaacttgcg cgcgcgctcg cgccactgcg      420

cccggagcga tgaagatggt cgcgccctgg acgcggttct actccaacag ctgctgcttg      480

tgctgccatg tccgcaccgg caccatcctg ctcggcgtct ggtatctgat catcaatgct      540

gtggtactgt tgattttatt gagtgccctg gctgatccgg atcagtataa cttttcaagt      600

tctgaactgg gaggtgactt tgagttcatg gatgatgcca acatgtgcat tgccattgcg      660

atttctcttc tcatgatcct gatatgtgct atggctactt acggagcgta caagcaacgc      720

gcagcctgga tcatcccatt cttctgttac cagatctttg actttgccct gaacatgttg      780

gttgcaatca ctgtgcttat ttatccaaac tccattcagg aatacatacg gcaactgcct      840

cctaattttc cctacagaga tgatgtcatg tcagtgaatc ctacctgttt ggtccttatt      900

attcttctgt ttattagcat tatcttgact tttaagggtt acttgattag ctgtgtttgg      960

aactgctacc gatacatcaa tggtaggaac tcctctgatg tcctggttta tgttaccagc     1020

aatgacacta cggtgctgct acccccgtat gatgatgcca ctgtgaatgg tgctgccaag     1080

gagccaccgc caccttacgt gtctgcctaa gccttcaagt gggcggagct gagggcagca     1140

gcttgacttt gcagacatct gagcaatagt tctgttattt cacttttgcc atgagcctct     1200

ctgagcttgt ttgttgctga aatgctactt tttaaaattt agatgttaga ttgaaaactg     1260

tagttttcaa catatgcttt gctggaacac tgtgatagat taactgtaga attcttcctg     1320

tacgattggg gatataatgg gcttcactaa ccttccctag gcattgaaac ttcccccaaa     1380

tctgatggac ctagaagtct gcttttgtac ctgctgggcc ccaaagttgg gcatttttct     1440

ctctgttccc tctcttttga aaatgtaaaa taaaaccaaa aatagacaac tttttcttca     1500

gccattccag catagagaac aaaaccttat ggaaacagga atgtcaattg tgtaatcatt     1560

gttctaatta ggtaaataga agtccttatg tatgtgttac aagaatttcc cccacaacat     1620

cctttatgac tgaagttcaa tgacagtttg tgtttggtgg taaaggattt tctccatggc     1680

ctgaattaag accattagaa agcaccaggc cgtgggagca gtgaccatct gctgactgtt     1740

cttgtggatc ttgtgtccag ggacatgggg tgacatgcct cgtatgtgtt agagggtgga     1800

atggatgtgt ttggcgctgc atgggatctg gtgcccctct tctcctggat tcacatcccc     1860

acccagggcc cgcttttact aagtgttctg ccctagattg gttcaaggag gtcatccaac     1920

tgactttatc aagtggaatt gggatatatt tgatatactt ctgcctaaca acatggaaaa     1980

gggttttctt ttccctgcaa gctacatcct actgctttga acttccaagt atgtctagtc     2040

accttttaaa atgtaaacat tttcagaaaa atgaggattg ccttccttgt atgcgctttt     2100

taccttgact acctgaattg caagggattt ttatatattc atatgttaca aagtcagcaa     2160

ctctcctgtt ggttcattat tgaatgtgct gtaaattaag ttgtttgcaa ttaaaacaag     2220

gtttgcccac atccaagaaa aa                                              2242


<210>  693
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  693

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  694
<211>  2631
<212>  DNA
<213>  Homo Sapiens

<400>  694
tctggggccg gactagccca gcgcgtctgc ctacccatag ggattccctc tccagccaat       60

ccagtcagag cagcggagct gccccgaaca aagatggcgc gggaagcgtc tgtgagggca      120

gactgatccg agcacccaaa ccctcggcgg acagcggagc cagtggtagc cgcacggccc      180

taaaaccatg gaggagggcg gcagcactgg cagtgctggc agtgacagca gcaccagcgg      240

gagtggcggg gcgcagcaaa gggagctgga gcgcatggct gaggtcttgg tcaccgggga      300

acagctacgg ctcaggctgc acgaagaaaa ggttattaaa gatagacgtc atcatctcaa      360

gacctaccca aactgttttg tcgcaaaaga actgattgac tggctgattg aacacaaaga      420

ggcttctgac agagagacgg caattaaact catgcagaaa ttagcagacc ggggcattat      480

tcaccatgtg tgtgatgagc ataaggaatt caaggatgtc aaactcttct accgctttag      540

aaaggatgac ggcaccttcc cattggataa tgaagtgaag gcctttatga gaggacagag      600

gctatatgaa aagctgatga gccctgaaaa cacactcctg cagcccaggg aggaggaagg      660

ggtcaagtat gagcgcacct tcatggcatc tgaattcctg gactggctgg ttcaggaagg      720

tgaggccacc acgaggaaag aggcagagca gctttgccac cggcttatgg agcatggcat      780

catccagcat gtgtccaaca agcacccatt tgtggacagc aatcttctct accagttcag      840

aatgaacttc cggcggaggc gaagactgat ggagctgctc aatgaaaagt ccccctcctc      900

ccaggaaact catgacagtc ccttctgcct gaggaagcag agccatgaca atcggaaatc      960

taccagcttt atgtcagtga gccccagcaa ggagatcaag atcgtgtctg cagtgaggag     1020

aagcagcatg agcagctgtg gcagcagcgg ctacttcagc agcagcccca ccctcagcag     1080

cagcccccct gtgctctgca accccaagtc cgtgctgaag agacctgtca cctctgagga     1140

actccttact cccggggctc cgtatgcaag gaagacattc acgattgttg gtgacgcggt     1200

tggctggggt tttgtggtgc gaggaagtaa gccatgccac atccaggctg tagaccccag     1260

tggccctgca gccgcagcag gaatgaaggt ctgtcagttt gtcgtctctg tcaacgggct     1320

caatgtcctg catgtagact accggaccgt gagcaatctg attctgacgg gcccacggac     1380

gattgtcatg gaagtcatgg aggagttaga gtgctgagct cctgggcctc ccagccctcc     1440

agtggcctgt gggtgaggga agccagaatg acacaaagca atgcaaagac aagattgcca     1500

tgcaaatgga tggttttgga catacgagtc ttctccgcac atacatgtct aaagttgagt     1560

tttatacact gaatgtggaa gaaccgggta tcatatcttt tttaaaaaat gtcagtgtag     1620

aaaacatttg ggaaaccatt ttcctacatg atagaactgc cttactagat ttctatttgt     1680

agctctcatt cattgttttt tatcttagtt tgcagaaagg tgttgaaatg cttctctagc     1740

ccaaacagcg acatgctaaa gtccccttct tcagagtcaa tagagtagtt gttaaaggtt     1800

ttaaattgta ctttctccaa aattagcatg cagctattta atagggaatc tagatttcac     1860

caagattcaa atcaaagcaa catttaaagg aataagacct gttcactagc attttcaagg     1920

gggttctaaa gcattcaagt gcttaaaagc cataaaaaat gacttcttaa ttcctgcctt     1980

tagtgtcaac ttttaagtta atacaggttt caattgtggc attaggaaaa aaaaaaacct     2040

tgtgatgcta tggttggggg tagttaggga gagactacat gaaattgtgt gcccctattt     2100

tctttctgat cctaaatcat tttgttttat aaatcagcta tagcatcttt ctagaattaa     2160

tcctgaatat gttgaatgtt aaaatagaga agtttgtata tacacataat taaaaatcaa     2220

cccttctggc aagatttcac tttgaaggtg tctgttttta agggaaggct aaaactttgc     2280

tgatatgtga taaaacttga actctaaatt gcctccttag cctgaatttt tactagcttt     2340

ctagtgtaac atattctaag gacatgacat gctgcttatt tggggggatt atttttcacc     2400

aaaatgatca tcttgtgttg taacttttca gctcacttgt atatacgcac gttttcattt     2460

ttggtctaga aaatagtgca ttttggggct cagcgtgcag aggaaattcc tcaaagtgcc     2520

aaattaggca gtcaggaaat actaaattct tcattccaaa taatggatct gaatgatgac     2580

gttaattttt tatcatgcat taacaaaata aaatatgaga attgtaccac a              2631


<210>  695
<211>  409
<212>  PRT
<213>  Homo Sapiens

<400>  695

Met Glu Glu Gly Gly Ser Thr Gly Ser Ala Gly Ser Asp Ser Ser Thr 
1               5                   10                  15      


Ser Gly Ser Gly Gly Ala Gln Gln Arg Glu Leu Glu Arg Met Ala Glu 
            20                  25                  30          


Val Leu Val Thr Gly Glu Gln Leu Arg Leu Arg Leu His Glu Glu Lys 
        35                  40                  45              


Val Ile Lys Asp Arg Arg His His Leu Lys Thr Tyr Pro Asn Cys Phe 
    50                  55                  60                  


Val Ala Lys Glu Leu Ile Asp Trp Leu Ile Glu His Lys Glu Ala Ser 
65                  70                  75                  80  


Asp Arg Glu Thr Ala Ile Lys Leu Met Gln Lys Leu Ala Asp Arg Gly 
                85                  90                  95      


Ile Ile His His Val Cys Asp Glu His Lys Glu Phe Lys Asp Val Lys 
            100                 105                 110         


Leu Phe Tyr Arg Phe Arg Lys Asp Asp Gly Thr Phe Pro Leu Asp Asn 
        115                 120                 125             


Glu Val Lys Ala Phe Met Arg Gly Gln Arg Leu Tyr Glu Lys Leu Met 
    130                 135                 140                 


Ser Pro Glu Asn Thr Leu Leu Gln Pro Arg Glu Glu Glu Gly Val Lys 
145                 150                 155                 160 


Tyr Glu Arg Thr Phe Met Ala Ser Glu Phe Leu Asp Trp Leu Val Gln 
                165                 170                 175     


Glu Gly Glu Ala Thr Thr Arg Lys Glu Ala Glu Gln Leu Cys His Arg 
            180                 185                 190         


Leu Met Glu His Gly Ile Ile Gln His Val Ser Asn Lys His Pro Phe 
        195                 200                 205             


Val Asp Ser Asn Leu Leu Tyr Gln Phe Arg Met Asn Phe Arg Arg Arg 
    210                 215                 220                 


Arg Arg Leu Met Glu Leu Leu Asn Glu Lys Ser Pro Ser Ser Gln Glu 
225                 230                 235                 240 


Thr His Asp Ser Pro Phe Cys Leu Arg Lys Gln Ser His Asp Asn Arg 
                245                 250                 255     


Lys Ser Thr Ser Phe Met Ser Val Ser Pro Ser Lys Glu Ile Lys Ile 
            260                 265                 270         


Val Ser Ala Val Arg Arg Ser Ser Met Ser Ser Cys Gly Ser Ser Gly 
        275                 280                 285             


Tyr Phe Ser Ser Ser Pro Thr Leu Ser Ser Ser Pro Pro Val Leu Cys 
    290                 295                 300                 


Asn Pro Lys Ser Val Leu Lys Arg Pro Val Thr Ser Glu Glu Leu Leu 
305                 310                 315                 320 


Thr Pro Gly Ala Pro Tyr Ala Arg Lys Thr Phe Thr Ile Val Gly Asp 
                325                 330                 335     


Ala Val Gly Trp Gly Phe Val Val Arg Gly Ser Lys Pro Cys His Ile 
            340                 345                 350         


Gln Ala Val Asp Pro Ser Gly Pro Ala Ala Ala Ala Gly Met Lys Val 
        355                 360                 365             


Cys Gln Phe Val Val Ser Val Asn Gly Leu Asn Val Leu His Val Asp 
    370                 375                 380                 


Tyr Arg Thr Val Ser Asn Leu Ile Leu Thr Gly Pro Arg Thr Ile Val 
385                 390                 395                 400 


Met Glu Val Met Glu Glu Leu Glu Cys 
                405                 


<210>  696
<211>  2268
<212>  DNA
<213>  Homo Sapiens

<400>  696
aatatcttgc atgttacaga tttcactgct cccaccagct tggagacaac atgtggttct       60

tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca aaggcagtga      120

tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc ttgcactgtg      180

aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc acagccactc      240

agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt ggtgaataca      300

ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc cacagaggct      360

ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg gccttgaggt      420

gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat ggcaaagcct      480

ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata agtcacaatg      540

gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga atatctgtca      600

ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc ccactcctgg      660

aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg cctggtttgc      720

agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac acatcctctg      780

aataccaaat actaactgct agaagagaag actctgggtt atactggtgc gaggctgcca      840

cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg cttggcctcc      900

agttaccaac tcctgtctgg tttcatgtcc ttttctatct ggcagtggga ataatgtttt      960

tagtgaacac tgttctctgg gtgacaatac gtaaagaact gaaaagaaag aaaaagtggg     1020

atttagaaat ctctttggat tctggtcatg agaagaaggt aatttccagc cttcaagaag     1080

acagacattt agaagaagag ctgaaatgtc aggaacaaaa agaagaacag ctgcaggaag     1140

gggtgcaccg gaaggagccc cagggggcca cgtagcagcg gctcagtggg tggccatcga     1200

tctggaccgt cccctgccca cttgctcccc gtgagcactg cgtacaaaca tccaaaagtt     1260

caacaacacc agaactgtgt gtctcatggt atgtaactct taaagcaaat aaatgaactg     1320

acttcaactg ggatacattt ggaaatgtgg tcatcaaaga tgacttgaaa tgaggcctac     1380

tctaaagaat tcttgaaaaa cttacaagtc aagcctagcc tgataatcct attacatagt     1440

ttgaaaaata gtattttatt tctcagaaca aggtaaaaag gtgagtgggt gcatatgtac     1500

agaagattaa gacagagaaa cagacagaaa gagacacaca cacagccagg agtgggtaga     1560

tttcagggag acaagaggga atagtataga caataaggaa ggaaatagta cttacaaatg     1620

actcctaagg gactgtgaga ctgagagggc tcacgcctct gtgttcagga tacttagttc     1680

atggcttttc tctttgactt tactaaaaga gaatgtctcc atacgcgttc taggcataca     1740

agggggtaac tcatgatgag aaatggatgt gttattcttg ccctctcttt tgaggctctc     1800

tcataacccc tctatttcta gagacaacaa aaatgctgcc agtcctaggc ccctgccctg     1860

taggaaggca gaatgtaact gttctgtttg tttaacgatt aagtccaaat ctccaagtgc     1920

ggcactgcaa agagacgctt caagtgggga gaagcggcga taccatagag tccagatctt     1980

gcctccagag atttgcttta ccttcctgat tttctggtta ctaattagct tcaggatacg     2040

ctgctctcat acttgggctg tagtttggag acaaaatatt ttcctgccac tgtgtaacat     2100

agctgaggta aaaactgaac tatgtaaatg actctactaa aagtttaggg aaaaaaaaca     2160

ggaggagtat gacacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  2268


<210>  697
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  697

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  698
<211>  4802
<212>  DNA
<213>  Homo Sapiens

<400>  698
atatttcagg ggatatgaat cccctacatt aagtaaggat tatgagggct acccagcccc       60

agcaatgcca gattttcaac ctggggatac cacagtaaga ctagacaaaa gaatgtctct      120

tactgcaata tatgacaaga ggagagagac agattatagt gacaaaggat ataatttagc      180

ttttgtttct caagatgaac aagaaaattc ttcctttact atattatacg aagagcccct      240

tcaagaggag gacaagtatg cttccgcaga agcaagacaa acacagtctg tcttgtttca      300

tgatacgtcc gctgacagca tgcctgttct ggcatgtgaa aggtctgaga gtagaactga      360

ccttgtccat cactttgaaa aaggtactaa attaggtgag acatttgata gtgatagttc      420

agaaatgttc ttatcagtgg aggccaaaag gtacaaaatt tatcctttag cattgtctcc      480

catttatgag gatgacagct cacaggagga cattctatct agtgaggttt cacctggtca      540

ccatggcccc aggaaatcaa gagacagtga aaaccagtcc tcttctgttt tatcccttct      600

ccagtcagtg tcagaacgtt taaagatgaa ttttgatgaa gatgacagag aggcagctga      660

tgaggaagaa gaggaggagg aggcagcagt attgcataaa ggagatctga gagctggaag      720

tggggagcgt gttaccttcc agttgccaga tccttccatc acattttacc ctgatgacca      780

ggagagcgtt ggaatttcta agaattcata tgtgatgcca aatgaaccta ctacctccaa      840

tctgcaagtt ggtctgtggc cagaaaagac ctcgtttctc cagaaatctg accttacttc      900

taaactacat tcttctttaa agagtgctta tcatcagtat ctgcagactt cccaaagtca      960

ttcctcagaa aaaggagcca gatttggtgg aatttttcag gaaccagtgt caaaatattt     1020

ccgtgttcaa gacagcccag gcagattgag cccatttata gagaatgttg acaaacaaac     1080

tctgagatgt aacccaagac ctgggaagat ggttatctat gatctccatg aaagtacata     1140

taaacaagaa gtctactgta atattcctga tgctacatca tggtcttttc caaatggagt     1200

tctaataaaa gttgtaaggg gctgctggat tttatatgag aaaccacatt tccgaggtca     1260

gaaatgtgtg ctagaagaag gggaaaaggt gttaaatcgt gactggattc ttcagaacag     1320

aaggcatcca caaagaaact ttatattggg ttctctcaaa cgtgtcttaa aggactgcag     1380

cattccagaa atagagcttt tcccacaatc tgacccagcc tgttgtcctg tctacataca     1440

gagagcagtc cccaatttgg aagaactgaa tatctccaaa tctgtgtcct tcactgtgaa     1500

gtcaggagtt tggcttgcct acccagatat taattttaag ggacaagcta cagttctgga     1560

ggaagaccat gggctctttg agatttctac agcagaaatg aaatcattac atccgcttca     1620

aatgggtgga ctgaaagtgg aaatgcccat gaacttaaag gttattattt atgaaaaacc     1680

tcacttccat ggacaggcta aagagtttag tgaacatata gattctgttc ctaatttttt     1740

gaaaaataat ggagattttc acagaattgg atcaattcgt gtcattggtg gagtgtgggt     1800

tgcctatgaa aaagaacatt ttaaaggcca gcagtttctg cttgaagaag gagactttga     1860

agacagtaat gcttgtggtg cattaagtag ccctatcttg tctttccggt acttacaagc     1920

taattttata gaatcttctg tcacactatt tgaatctgac ctagaaagtg ggaagtttat     1980

tgacattaca aatcaggaaa tttctgattt ggaagaaatt ggctttggca gtaaaacaag     2040

atccattcat gttaaaagtg gagtatgggt tgcctaccag caaaagttct tctgtggaga     2100

acaatacatt ttagaaaaag ggaaatacaa atgctttttt gactggggag gatcaaataa     2160

tataatcatg tcgatacggc caatccaact ggaaccactt gggataaatg aacctccgca     2220

tttgctcaaa gcattcagca aaccagggtt ccaaggtgaa tgtatagatt ttacagaaga     2280

aacttctgat ttgacttcac tcatgccatg ttcttttaaa gttcttcgag gttgctggct     2340

cctctattac caagaagaca tgtttgttaa tcactgtgtg ttagaagaag gcctctatgc     2400

tgaccttact tcctgcggtt gcccagcatc taaagtcaaa tctctcaagc ccattgacta     2460

tgtttttgaa gaaccctcca tcagcctttt tgctctggag cattgtgagg gaagagagtt     2520

acatctagaa gaggctgtga actctgttct gaacaaggac ctacacttct acacccagtc     2580

tgtgtgggta aaaagtggac tatggatagc ttatgaagga tccaatttct tgggaagaca     2640

aatcctactc aggcctaatg agatcccaaa ctggacagca ttcagcagat ggaaaacaat     2700

tggttccctc cgtcctatga agcagcctgc agtgtacatc agaataaaga accgtgccca     2760

gggtgaatat ctgacagtca ctggaagtct agcagacacc agggcaacat ctgtgtgcat     2820

ttctccctat agtggaaaga atactcagat ctggtactac tgccgaggac tctttaaatc     2880

caaggccagt gatacatgtc ttgatgtgat tggtggccgg gacacacctg gagctaaagt     2940

agctctatgg actgaacatg ggcaattcag gcagaagtgg agactgaata aaaatggaac     3000

tatcagctct tatctcagtg atcaacttgt ccttgatgtt aaaggaggaa attattgtga     3060

caagactcat gtaattgtaa atcagcccct ggagggagaa gaaacacaga aatgggacat     3120

tgaaatattg tgagagaatc aacatcccta gaaagatccc tagaaagagc aaagaaggaa     3180

acacatctgt cattgtcttg tggacgtgga aaggaagcta ctgtcctcac actcctggat     3240

cactgagcag aatgaacatt ttctccagcc tctgagacta tcgctcttaa ccatggaaaa     3300

gctcaaaata ttcttgccat tactcagtgt tcctataaag aaaatattat gatatcttgg     3360

aaaggttcta ttcctgatct ccagctgtgg tgagcaagtt tcctgaagtg tttattttct     3420

ctcatatcca ccaaacgtga atcctgttcc tgatggcccg ttattggaca ctggtgatgc     3480

tattatcctg tattatttat taatatccta cctagatgct tgtatgagta caaagcataa     3540

agaaacagat ttctataggt caagtcatac ttttgcaaac agatgagtaa ttttttagca     3600

acacctgaaa atatactaaa ctttcctaga taaactttaa ggtttctata ctgaggcttt     3660

tataatgaac gcacctcgtt aagtatttat acttgtaact aaccccaggc agggacctca     3720

gctttgttag gaataaggca caagaagtat tttctgtagc tattgtttcc tcagtccttc     3780

aaactaaaaa agtacaaata aataacctat ggccaaactt gcactgttac gtgttaacca     3840

agacatccct ttaggtgaca agactctata acagtggtta cctgtctcca tgttgacact     3900

tcatcctaga tttaaggaga ggcatcaatt tttttttttt tttgcctcaa gagaaatttc     3960

aaatatccaa attaaaacac agtagcattt gaaccttgac cttaccatct ctttaagtaa     4020

acgtggagtt gatttctcta ctaaataaca gaaacctcag tttttcactc ccattgtaag     4080

taacttttat ttaagtaagt aaaatcaggt aggaaatcac ctttgactta gcttccagta     4140

gtcattacca ccttttactg cacaattcac aagcatgttt tcctggtgaa ttggactgaa     4200

aattacattt tgacaacttt ttttcctttt atccccaact tttgccagaa agcagaaaaa     4260

tgctctattt ttataaagaa agattaaatt ctccaatgat attttaaaaa atatcaacct     4320

acatgcactt tagaatgtaa aataacaatg actattttaa actcgaagac ccactatttt     4380

gagtattttt tatagacttt aaatactggg tttttttcct ccttcaatct caggcttttc     4440

tccatctttt aagcagcctc tgtaactccc ttttgtccat aggtgttgcg tgcctctcat     4500

ctgtggggaa gtattattta ataaaattta tgttacagga taactttatt ttaatgggca     4560

tgggcttgtc tatacacaaa ggtatgtata ttttcattat aaaaaaccag tttaaaattt     4620

tttcttattt taattgtttg aaatttttct agagccaaag aagctcttta aagaagttgt     4680

ttcttccaaa gaacaaagcc aggttaatga cattcaattc taaatgatac attggaattg     4740

tgccttttct accacactgg attaaataaa cttgtcaaaa tatggaaaaa aaaaaaaaaa     4800

aa                                                                    4802


<210>  699
<211>  1022
<212>  PRT
<213>  Homo Sapiens

<400>  699

Met Pro Asp Phe Gln Pro Gly Asp Thr Thr Val Arg Leu Asp Lys Arg 
1               5                   10                  15      


Met Ser Leu Thr Ala Ile Tyr Asp Lys Arg Arg Glu Thr Asp Tyr Ser 
            20                  25                  30          


Asp Lys Gly Tyr Asn Leu Ala Phe Val Ser Gln Asp Glu Gln Glu Asn 
        35                  40                  45              


Ser Ser Phe Thr Ile Leu Tyr Glu Glu Pro Leu Gln Glu Glu Asp Lys 
    50                  55                  60                  


Tyr Ala Ser Ala Glu Ala Arg Gln Thr Gln Ser Val Leu Phe His Asp 
65                  70                  75                  80  


Thr Ser Ala Asp Ser Met Pro Val Leu Ala Cys Glu Arg Ser Glu Ser 
                85                  90                  95      


Arg Thr Asp Leu Val His His Phe Glu Lys Gly Thr Lys Leu Gly Glu 
            100                 105                 110         


Thr Phe Asp Ser Asp Ser Ser Glu Met Phe Leu Ser Val Glu Ala Lys 
        115                 120                 125             


Arg Tyr Lys Ile Tyr Pro Leu Ala Leu Ser Pro Ile Tyr Glu Asp Asp 
    130                 135                 140                 


Ser Ser Gln Glu Asp Ile Leu Ser Ser Glu Val Ser Pro Gly His His 
145                 150                 155                 160 


Gly Pro Arg Lys Ser Arg Asp Ser Glu Asn Gln Ser Ser Ser Val Leu 
                165                 170                 175     


Ser Leu Leu Gln Ser Val Ser Glu Arg Leu Lys Met Asn Phe Asp Glu 
            180                 185                 190         


Asp Asp Arg Glu Ala Ala Asp Glu Glu Glu Glu Glu Glu Glu Ala Ala 
        195                 200                 205             


Val Leu His Lys Gly Asp Leu Arg Ala Gly Ser Gly Glu Arg Val Thr 
    210                 215                 220                 


Phe Gln Leu Pro Asp Pro Ser Ile Thr Phe Tyr Pro Asp Asp Gln Glu 
225                 230                 235                 240 


Ser Val Gly Ile Ser Lys Asn Ser Tyr Val Met Pro Asn Glu Pro Thr 
                245                 250                 255     


Thr Ser Asn Leu Gln Val Gly Leu Trp Pro Glu Lys Thr Ser Phe Leu 
            260                 265                 270         


Gln Lys Ser Asp Leu Thr Ser Lys Leu His Ser Ser Leu Lys Ser Ala 
        275                 280                 285             


Tyr His Gln Tyr Leu Gln Thr Ser Gln Ser His Ser Ser Glu Lys Gly 
    290                 295                 300                 


Ala Arg Phe Gly Gly Ile Phe Gln Glu Pro Val Ser Lys Tyr Phe Arg 
305                 310                 315                 320 


Val Gln Asp Ser Pro Gly Arg Leu Ser Pro Phe Ile Glu Asn Val Asp 
                325                 330                 335     


Lys Gln Thr Leu Arg Cys Asn Pro Arg Pro Gly Lys Met Val Ile Tyr 
            340                 345                 350         


Asp Leu His Glu Ser Thr Tyr Lys Gln Glu Val Tyr Cys Asn Ile Pro 
        355                 360                 365             


Asp Ala Thr Ser Trp Ser Phe Pro Asn Gly Val Leu Ile Lys Val Val 
    370                 375                 380                 


Arg Gly Cys Trp Ile Leu Tyr Glu Lys Pro His Phe Arg Gly Gln Lys 
385                 390                 395                 400 


Cys Val Leu Glu Glu Gly Glu Lys Val Leu Asn Arg Asp Trp Ile Leu 
                405                 410                 415     


Gln Asn Arg Arg His Pro Gln Arg Asn Phe Ile Leu Gly Ser Leu Lys 
            420                 425                 430         


Arg Val Leu Lys Asp Cys Ser Ile Pro Glu Ile Glu Leu Phe Pro Gln 
        435                 440                 445             


Ser Asp Pro Ala Cys Cys Pro Val Tyr Ile Gln Arg Ala Val Pro Asn 
    450                 455                 460                 


Leu Glu Glu Leu Asn Ile Ser Lys Ser Val Ser Phe Thr Val Lys Ser 
465                 470                 475                 480 


Gly Val Trp Leu Ala Tyr Pro Asp Ile Asn Phe Lys Gly Gln Ala Thr 
                485                 490                 495     


Val Leu Glu Glu Asp His Gly Leu Phe Glu Ile Ser Thr Ala Glu Met 
            500                 505                 510         


Lys Ser Leu His Pro Leu Gln Met Gly Gly Leu Lys Val Glu Met Pro 
        515                 520                 525             


Met Asn Leu Lys Val Ile Ile Tyr Glu Lys Pro His Phe His Gly Gln 
    530                 535                 540                 


Ala Lys Glu Phe Ser Glu His Ile Asp Ser Val Pro Asn Phe Leu Lys 
545                 550                 555                 560 


Asn Asn Gly Asp Phe His Arg Ile Gly Ser Ile Arg Val Ile Gly Gly 
                565                 570                 575     


Val Trp Val Ala Tyr Glu Lys Glu His Phe Lys Gly Gln Gln Phe Leu 
            580                 585                 590         


Leu Glu Glu Gly Asp Phe Glu Asp Ser Asn Ala Cys Gly Ala Leu Ser 
        595                 600                 605             


Ser Pro Ile Leu Ser Phe Arg Tyr Leu Gln Ala Asn Phe Ile Glu Ser 
    610                 615                 620                 


Ser Val Thr Leu Phe Glu Ser Asp Leu Glu Ser Gly Lys Phe Ile Asp 
625                 630                 635                 640 


Ile Thr Asn Gln Glu Ile Ser Asp Leu Glu Glu Ile Gly Phe Gly Ser 
                645                 650                 655     


Lys Thr Arg Ser Ile His Val Lys Ser Gly Val Trp Val Ala Tyr Gln 
            660                 665                 670         


Gln Lys Phe Phe Cys Gly Glu Gln Tyr Ile Leu Glu Lys Gly Lys Tyr 
        675                 680                 685             


Lys Cys Phe Phe Asp Trp Gly Gly Ser Asn Asn Ile Ile Met Ser Ile 
    690                 695                 700                 


Arg Pro Ile Gln Leu Glu Pro Leu Gly Ile Asn Glu Pro Pro His Leu 
705                 710                 715                 720 


Leu Lys Ala Phe Ser Lys Pro Gly Phe Gln Gly Glu Cys Ile Asp Phe 
                725                 730                 735     


Thr Glu Glu Thr Ser Asp Leu Thr Ser Leu Met Pro Cys Ser Phe Lys 
            740                 745                 750         


Val Leu Arg Gly Cys Trp Leu Leu Tyr Tyr Gln Glu Asp Met Phe Val 
        755                 760                 765             


Asn His Cys Val Leu Glu Glu Gly Leu Tyr Ala Asp Leu Thr Ser Cys 
    770                 775                 780                 


Gly Cys Pro Ala Ser Lys Val Lys Ser Leu Lys Pro Ile Asp Tyr Val 
785                 790                 795                 800 


Phe Glu Glu Pro Ser Ile Ser Leu Phe Ala Leu Glu His Cys Glu Gly 
                805                 810                 815     


Arg Glu Leu His Leu Glu Glu Ala Val Asn Ser Val Leu Asn Lys Asp 
            820                 825                 830         


Leu His Phe Tyr Thr Gln Ser Val Trp Val Lys Ser Gly Leu Trp Ile 
        835                 840                 845             


Ala Tyr Glu Gly Ser Asn Phe Leu Gly Arg Gln Ile Leu Leu Arg Pro 
    850                 855                 860                 


Asn Glu Ile Pro Asn Trp Thr Ala Phe Ser Arg Trp Lys Thr Ile Gly 
865                 870                 875                 880 


Ser Leu Arg Pro Met Lys Gln Pro Ala Val Tyr Ile Arg Ile Lys Asn 
                885                 890                 895     


Arg Ala Gln Gly Glu Tyr Leu Thr Val Thr Gly Ser Leu Ala Asp Thr 
            900                 905                 910         


Arg Ala Thr Ser Val Cys Ile Ser Pro Tyr Ser Gly Lys Asn Thr Gln 
        915                 920                 925             


Ile Trp Tyr Tyr Cys Arg Gly Leu Phe Lys Ser Lys Ala Ser Asp Thr 
    930                 935                 940                 


Cys Leu Asp Val Ile Gly Gly Arg Asp Thr Pro Gly Ala Lys Val Ala 
945                 950                 955                 960 


Leu Trp Thr Glu His Gly Gln Phe Arg Gln Lys Trp Arg Leu Asn Lys 
                965                 970                 975     


Asn Gly Thr Ile Ser Ser Tyr Leu Ser Asp Gln Leu Val Leu Asp Val 
            980                 985                 990         


Lys Gly Gly Asn Tyr Cys Asp Lys  Thr His Val Ile Val  Asn Gln Pro 
        995                 1000                 1005             


Leu Glu  Gly Glu Glu Thr Gln  Lys Trp Asp Ile Glu  Ile Leu 
    1010                 1015                 1020         


<210>  700
<211>  1365
<212>  DNA
<213>  Homo Sapiens

<400>  700
atgcagctca gcctgggcta cacagccagg tgtcagatgt gtctctgctg atctgagtct       60

gcctgtggca tggacctgca tcttccctga agcatctcca gggctgaaaa atcactgacc      120

atggcaccat ggtctcatcc atctgcacag ctgcagccag tgggaggaga cgccgtgagc      180

cctgccctca tggttctgct ctgcctcggg ctgagtctgg gccccaggac ccacgtgcag      240

gcagggaacc tctccaaagc caccctctgg gctgagccag gctctgtgat cagccggggg      300

aactctgtga ccatccggtg tcaggggacc ctggaggccc aggaataccg tctggttaaa      360

gagggaagcc cagaaccctg ggacacacag aacccactgg agcccaagaa caaggccaga      420

ttctccatcc catccatgac agagcaccat gcagggagat accgctgtta ctactacagc      480

cctgcaggct ggtcagagcc cagcgacccc ctggagctgg tggtgacagg attctacaac      540

aaacccaccc tctcagccct gcccagtcct gtggtgacct caggagagaa cgtgaccctc      600

cagtgtggct cacggctgag attcgacagg ttcattctga ctgaggaagg agaccacaag      660

ctctcctgga ccttggactc acagctgacc cccagtgggc agttccaggc cctgttccct      720

gtgggccctg tgacccccag ccacaggtgg atgctcagat gctatggctc tcgcaggcat      780

atcctgcagg tatggtcaga acccagtgac ctcctggaga ttccggtctc aggagcagct      840

gataacctca gtccgtcaca aaacaagtct gactctggga ctgcctcaca ccttcaggat      900

tacgcagtag agaatctcat ccgcatgggc atggccggct tgatcctggt ggtccttggg      960

attctgatat ttcaggattg gcacagccag agaagccccc aagctgcagc tggaaggtga     1020

acagaagaga gaacaatgca ccattgaatg ctggagcctt ggaagcgaat ctgatggtcc     1080

taggaggttc gggaagacca tctgaggcct atgccatctg gactgtctgc tggcaatttc     1140

tttttttctt tcttttcttt tctttctttt tttttttttt tttttttttt ttgagatgga     1200

gtcttgctct gtcaccaggc tggaatgcag tggcgcaatc tgggctcact gcaacctccg     1260

cctctcgggt tcaagtgatt ctcctgcctc agcctctggc aatttctaga gggaggaatg     1320

ggtgtttgag tgcagagaca ctggtctggg gtgatccatg gagga                     1365


<210>  701
<211>  299
<212>  PRT
<213>  Homo Sapiens

<400>  701

Met Ala Pro Trp Ser His Pro Ser Ala Gln Leu Gln Pro Val Gly Gly 
1               5                   10                  15      


Asp Ala Val Ser Pro Ala Leu Met Val Leu Leu Cys Leu Gly Leu Ser 
            20                  25                  30          


Leu Gly Pro Arg Thr His Val Gln Ala Gly Asn Leu Ser Lys Ala Thr 
        35                  40                  45              


Leu Trp Ala Glu Pro Gly Ser Val Ile Ser Arg Gly Asn Ser Val Thr 
    50                  55                  60                  


Ile Arg Cys Gln Gly Thr Leu Glu Ala Gln Glu Tyr Arg Leu Val Lys 
65                  70                  75                  80  


Glu Gly Ser Pro Glu Pro Trp Asp Thr Gln Asn Pro Leu Glu Pro Lys 
                85                  90                  95      


Asn Lys Ala Arg Phe Ser Ile Pro Ser Met Thr Glu His His Ala Gly 
            100                 105                 110         


Arg Tyr Arg Cys Tyr Tyr Tyr Ser Pro Ala Gly Trp Ser Glu Pro Ser 
        115                 120                 125             


Asp Pro Leu Glu Leu Val Val Thr Gly Phe Tyr Asn Lys Pro Thr Leu 
    130                 135                 140                 


Ser Ala Leu Pro Ser Pro Val Val Thr Ser Gly Glu Asn Val Thr Leu 
145                 150                 155                 160 


Gln Cys Gly Ser Arg Leu Arg Phe Asp Arg Phe Ile Leu Thr Glu Glu 
                165                 170                 175     


Gly Asp His Lys Leu Ser Trp Thr Leu Asp Ser Gln Leu Thr Pro Ser 
            180                 185                 190         


Gly Gln Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His 
        195                 200                 205             


Arg Trp Met Leu Arg Cys Tyr Gly Ser Arg Arg His Ile Leu Gln Val 
    210                 215                 220                 


Trp Ser Glu Pro Ser Asp Leu Leu Glu Ile Pro Val Ser Gly Ala Ala 
225                 230                 235                 240 


Asp Asn Leu Ser Pro Ser Gln Asn Lys Ser Asp Ser Gly Thr Ala Ser 
                245                 250                 255     


His Leu Gln Asp Tyr Ala Val Glu Asn Leu Ile Arg Met Gly Met Ala 
            260                 265                 270         


Gly Leu Ile Leu Val Val Leu Gly Ile Leu Ile Phe Gln Asp Trp His 
        275                 280                 285             


Ser Gln Arg Ser Pro Gln Ala Ala Ala Gly Arg 
    290                 295                 


<210>  702
<211>  2268
<212>  DNA
<213>  Homo Sapiens

<400>  702
aatatcttgc atgttacaga tttcactgct cccaccagct tggagacaac atgtggttct       60

tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca aaggcagtga      120

tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc ttgcactgtg      180

aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc acagccactc      240

agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt ggtgaataca      300

ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc cacagaggct      360

ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg gccttgaggt      420

gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat ggcaaagcct      480

ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata agtcacaatg      540

gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga atatctgtca      600

ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc ccactcctgg      660

aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg cctggtttgc      720

agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac acatcctctg      780

aataccaaat actaactgct agaagagaag actctgggtt atactggtgc gaggctgcca      840

cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg cttggcctcc      900

agttaccaac tcctgtctgg tttcatgtcc ttttctatct ggcagtggga ataatgtttt      960

tagtgaacac tgttctctgg gtgacaatac gtaaagaact gaaaagaaag aaaaagtggg     1020

atttagaaat ctctttggat tctggtcatg agaagaaggt aatttccagc cttcaagaag     1080

acagacattt agaagaagag ctgaaatgtc aggaacaaaa agaagaacag ctgcaggaag     1140

gggtgcaccg gaaggagccc cagggggcca cgtagcagcg gctcagtggg tggccatcga     1200

tctggaccgt cccctgccca cttgctcccc gtgagcactg cgtacaaaca tccaaaagtt     1260

caacaacacc agaactgtgt gtctcatggt atgtaactct taaagcaaat aaatgaactg     1320

acttcaactg ggatacattt ggaaatgtgg tcatcaaaga tgacttgaaa tgaggcctac     1380

tctaaagaat tcttgaaaaa cttacaagtc aagcctagcc tgataatcct attacatagt     1440

ttgaaaaata gtattttatt tctcagaaca aggtaaaaag gtgagtgggt gcatatgtac     1500

agaagattaa gacagagaaa cagacagaaa gagacacaca cacagccagg agtgggtaga     1560

tttcagggag acaagaggga atagtataga caataaggaa ggaaatagta cttacaaatg     1620

actcctaagg gactgtgaga ctgagagggc tcacgcctct gtgttcagga tacttagttc     1680

atggcttttc tctttgactt tactaaaaga gaatgtctcc atacgcgttc taggcataca     1740

agggggtaac tcatgatgag aaatggatgt gttattcttg ccctctcttt tgaggctctc     1800

tcataacccc tctatttcta gagacaacaa aaatgctgcc agtcctaggc ccctgccctg     1860

taggaaggca gaatgtaact gttctgtttg tttaacgatt aagtccaaat ctccaagtgc     1920

ggcactgcaa agagacgctt caagtgggga gaagcggcga taccatagag tccagatctt     1980

gcctccagag atttgcttta ccttcctgat tttctggtta ctaattagct tcaggatacg     2040

ctgctctcat acttgggctg tagtttggag acaaaatatt ttcctgccac tgtgtaacat     2100

agctgaggta aaaactgaac tatgtaaatg actctactaa aagtttaggg aaaaaaaaca     2160

ggaggagtat gacacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                  2268


<210>  703
<211>  374
<212>  PRT
<213>  Homo Sapiens

<400>  703

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  704
<211>  3085
<212>  DNA
<213>  Homo Sapiens

<400>  704
attggacaat gcgcgtccgc cacgacgcag gaaggccgcc tcattggtcc gcgctgtcgg       60

gcttcggcgg cttttctctt tagcgctcag ggcgctgacc cactgctctt cctcttaaga      120

aagtgctcca ttccttccgg cgcccggagc tgctggccca aagggatccg gagcgagcta      180

gggcagacac catgaccacc cttgatgata agttgctggg ggagaaactg cagtactact      240

atagcagcag tgaggatgag gacagtgacc acgaggacaa ggaccgaggc agatgtgccc      300

cagccagcag ttctgtgcct gcagaggctg agctggcagg cgaaggcatc tcagttaaca      360

caggcccaaa aggtgtgatc aatgactggc gccgcttcaa gcagttggag acagagcaga      420

gggaggagca gtgccgggag atggaaaggc tgatcaagaa gctgtcaatg acttgcaggt      480

cccatctgga tgaagaggag gagcaacaga aacagaaaga cctccaggag aagatcagtg      540

ggaagatgac tctgaaggag tttgccataa tgaatgagga ccaagatgat gaagagtttc      600

tgcagcagta ccggaagcag cgaatggaag agatgcggca gcagcttcac aaggggcccc      660

aattcaagca ggtttttgag atctccagtg gagaagggtt tttagacatg attgataaag      720

aacagaaaag cattgtcatc atggttcata tttatgagga tggcattcca gggaccgaag      780

ccatgaatgg ttgcatgatc tgccttgccg cagagtaccc agctgtcaag ttctgcaagg      840

tgaagagctc agttattggc gccagcagtc agttcaccag gaatgccctt cctgccctgc      900

tgatctataa ggggggtgaa ttgatcggca attttgttcg tgttactgac cagctggggg      960

atgatttctt tgctgtggac cttgaagctt ttctccagga atttggatta ctcccagaaa     1020

aggaagtctt ggtgctgaca tctgtgcgta actctgccac gtgtcacagt gaggatagcg     1080

acctggaaat agattgaact gatagtctag ttgcatagat ttctcattgt ttgggttgga     1140

atacacgtca ttgtttattt ttgttccttt gtcttctggc ttttcagctg ttctttgtag     1200

tcccttttat tatgcataaa ataaagaaat tcttagatta aatcagaatg ctgaataacc     1260

ttgtagctag caataaggtg acttacagtt gtataaacag gaagccaggc ttttgaactg     1320

tttacttaag attctgtggt gtgacatctc tgttattgtt tccagtcaat atttacaaag     1380

catcctaaag acagggtctt ggaaattgtc ttcagatgat cttagaggtc tctgccaagt     1440

ctgagagtat aattctgtag gtattgtgtt atttgcaacg taaatagtgc attttcttaa     1500

tcaaatgatt gtaaattata tttacttgta atcagttcca tagctttaga cggtggttag     1560

attttttttt tccccaccag ggtcttgttt aaaggggtga gccaccgcac ccagtcctga     1620

ggggtggcct ctgctgctgg atttcatgtc ttcctccagc atgactaagt ctggaacagc     1680

aggaagggtt gatgcttact gacctggtga tgttagaaga caagtagttt atggatttaa     1740

acattagagc tggagtgggg ctggaaatct ttgtaaagga agttctttca gtaagatgcc     1800

cctgcttgtc tttgtctctt ttttgtttaa caaggtaact ttttgtttaa caaggtaact     1860

ttttgtttaa cctagatttt ttttaaaact tttttttttt ttcatattgg aaaagtaatt     1920

catattcagt agaggaaaac tgaccaaaac agaagcaaaa ataagaaaat taaaataatc     1980

tctaatccta ctacctagaa taaaacacta ttaatatttt ggtctgtttc ctgccaaggt     2040

gttttctgtg tatacatgga tattttgttt gtttttaaac aaaacgatgg gatcattctg     2100

aacatactgt tctatagtat ggtcagctaa taatatatca gacctttttt tatattatta     2160

aatattctac aactttttaa aaatgtctat taatattcca tcgtatagat gtgatataat     2220

ttgcttgatg gttgtctctt aaaaagaaag atagcaaata ctttttttaa attacaaaag     2280

tgatagatgt tcattgtaga aaatgtaata aacactgtta agacttaaaa gccatataat     2340

tccaccaacc aaaattaatc ccttttgtca tatttctagt catttttata gccttttttt     2400

ctatgtattt ataataatta tcatttgcgt ttttttcctt tttttaactt taaaaatgta     2460

tattctaggg tcaggggaaa tgtaatctgg aattaaatat tagccttaaa attcacaatt     2520

ttgattttcc tggcttttca ggaattgact aactgtaaaa gagtcttgaa agtatttagt     2580

caacaaacag agtgcatttt tttttttttt gactaagaaa gctcgttgta gtagaaaggg     2640

tggaatgtat tgaaaattat tagaagcagg gaagtattgt tagtctagct tatttccttt     2700

cagtcttttt tcaatatttt tataaacatt gagtacttac tgaatttagt tctgtgctct     2760

tccttattta gtgttgtatc ataaatactt tgatgtttca aacattctaa ataaataatt     2820

ttcagtggct tcataatatt tcatcatttg gatatataat aatttattta accagtctct     2880

ttatttttat ttatttattt tgtttgtttt ctttgagatg gagtctcgct ctgtcaccca     2940

ggctggagta caatagcgtg atctcggctc actgcaacct ccacctcctg ggttcaagca     3000

gttctcctgc ctcagcctcc tgagtagctg ggactacagg cacatgccat cacgcctggc     3060

taatttttgt atttttacta gagac                                           3085


<210>  705
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  705

Met Thr Thr Leu Asp Asp Lys Leu Leu Gly Glu Lys Leu Gln Tyr Tyr 
1               5                   10                  15      


Tyr Ser Ser Ser Glu Asp Glu Asp Ser Asp His Glu Asp Lys Asp Arg 
            20                  25                  30          


Gly Arg Cys Ala Pro Ala Ser Ser Ser Val Pro Ala Glu Ala Glu Leu 
        35                  40                  45              


Ala Gly Glu Gly Ile Ser Val Asn Thr Gly Pro Lys Gly Val Ile Asn 
    50                  55                  60                  


Asp Trp Arg Arg Phe Lys Gln Leu Glu Thr Glu Gln Arg Glu Glu Gln 
65                  70                  75                  80  


Cys Arg Glu Met Glu Arg Leu Ile Lys Lys Leu Ser Met Thr Cys Arg 
                85                  90                  95      


Ser His Leu Asp Glu Glu Glu Glu Gln Gln Lys Gln Lys Asp Leu Gln 
            100                 105                 110         


Glu Lys Ile Ser Gly Lys Met Thr Leu Lys Glu Phe Ala Ile Met Asn 
        115                 120                 125             


Glu Asp Gln Asp Asp Glu Glu Phe Leu Gln Gln Tyr Arg Lys Gln Arg 
    130                 135                 140                 


Met Glu Glu Met Arg Gln Gln Leu His Lys Gly Pro Gln Phe Lys Gln 
145                 150                 155                 160 


Val Phe Glu Ile Ser Ser Gly Glu Gly Phe Leu Asp Met Ile Asp Lys 
                165                 170                 175     


Glu Gln Lys Ser Ile Val Ile Met Val His Ile Tyr Glu Asp Gly Ile 
            180                 185                 190         


Pro Gly Thr Glu Ala Met Asn Gly Cys Met Ile Cys Leu Ala Ala Glu 
        195                 200                 205             


Tyr Pro Ala Val Lys Phe Cys Lys Val Lys Ser Ser Val Ile Gly Ala 
    210                 215                 220                 


Ser Ser Gln Phe Thr Arg Asn Ala Leu Pro Ala Leu Leu Ile Tyr Lys 
225                 230                 235                 240 


Gly Gly Glu Leu Ile Gly Asn Phe Val Arg Val Thr Asp Gln Leu Gly 
                245                 250                 255     


Asp Asp Phe Phe Ala Val Asp Leu Glu Ala Phe Leu Gln Glu Phe Gly 
            260                 265                 270         


Leu Leu Pro Glu Lys Glu Val Leu Val Leu Thr Ser Val Arg Asn Ser 
        275                 280                 285             


Ala Thr Cys His Ser Glu Asp Ser Asp Leu Glu Ile Asp 
    290                 295                 300     


<210>  706
<211>  4299
<212>  DNA
<213>  Homo Sapiens

<400>  706
gcccacccgc tgaccaacgc cgccgccccc gccgggcggt gctgtgtccc cgcaggagtc       60

ggagaggatg gcaggggccg gaggccagca ccaccctccg ggcgccgctg gaggagcggc      120

cgccggagcc ggcgccgcgg tcacctccgc cgctgcctcg gcggggccgg gagaggattc      180

gtctgacagc gaagcggagc aagagggacc ccagaaactg atccgcaaag tgtctacctc      240

ggggcagatc cggaccaaga ccagtattaa agagggacag ctattgaagc aaaccagttc      300

tttccaaagg tggaaaaagc gatacttcaa acttcgaggc cgcacccttt actatgcaaa      360

ggactcaaag tctctgatat ttgatgaagt tgacctctca gatgctagtg tagctgaagc      420

aagcacgaaa aatgctaaca acagcttcac gatcatcact ccattcagaa ggctaatgct      480

gtgtgctgag aacagaaagg agatggagga ttggatcagc tcactgaagt ctgtacagac      540

cagagaaccc tacgaggtgg cccagtttaa tgtggaacat ttctcaggga tgcacaactg      600

gtacgcctgc tcccacgccc gacccacctt ctgtaacgtg tgcagagaga gtctttctgg      660

agtcacctcc catggcctgt cctgcgaagt gtgtaaattc aaggctcaca aaagatgtgc      720

agtgagagca acaaataact gtaaatggac taccctggcc tccatcggga aggacattat      780

agaagatgaa gatggcgtcg cgatgcctca ccagtggctt gagggcaacc tgcctgtaag      840

tgccaagtgt gctgtctgcg acaaaacatg tggcagtgtt ctccgtctac aggattggaa      900

atgcctttgg tgtaagacaa tggtacacac tgcctgcaaa gatttatacc atccaatatg      960

tccacttggt caatgtaaag tatctatcat acctccaatt gcactaaaca gcaccgattc     1020

cgatggtttc tgtagagcaa cattttcgtt ctgtgttagt cctctattgg tttttgtcaa     1080

ttctaagagt ggagataatc agggagtaaa gttcctccgt cgctttaaac agttgctaaa     1140

tccggctcag gtgtttgatt taatgaatgg aggtcctcat ttaggtttaa gattatttca     1200

gaagtttgac aatttccgga ttcttgtttg tggaggcgat ggaagtgtag gttgggtttt     1260

gtcagaaatc gataagctca acttgaataa acagtgtcag ctgggagtgt tgcctttggg     1320

tacaggaaat gaccttgccc gagttcttgg ctggggaggt tcatatgacg atgacaccca     1380

acttcctcag atcctagaga aactggaacg agccagtacc aaaatgttgg acaggtggag     1440

tataatgaca tatgaactca aattgccacc aaaagcttcc ctacttccag gacctccaga     1500

agcatctgaa gaattttata tgacgattta tgaagactca gttgcaacgc atcttacaaa     1560

aatcctcaat tctgatgaac atgcagtggt catatcttct gccaagacgc tatgtgaaac     1620

tgtaaaggac ttcgttgcca aagtagaaaa gacgtatgac aaaaccttgg aaaatgccgt     1680

tgtagctgat gccgtggcca gtaaatgttc agtcctaaac gagaagctcg aacaactgct     1740

gcaggctttg cacacagatt cccaggctgc gcctgttctc cctggcctca gccctctcat     1800

tgtggaagaa gatgctgtgg aatcgtccag tgaagagtcc ctgggtgaaa gcaaagagca     1860

gcttggggat gacgttacaa aaccttcctc ccagaaagcc gtcaaaccaa gggaaatcat     1920

gttgcgggca aatagtttaa agaaagcagt gaggcaagtc attgaggaag ccggaaaagt     1980

tatggatgac ccgacagttc acccctgtga accagctaat cagtcctctg attatgacag     2040

cacagaaaca gatgaatcta aggaggaagc taaagatgat ggtgccaaag aatcaataac     2100

tgttaaaact gcacctcggt ctccagatgc ccgggcaagt tatggccatt cccaaactga     2160

ttctgtccct ggtccagctg tggcagccag caaagaaaac ctccctgtgc tcaataccag     2220

aataatctgc ccaggtttaa gagcaggact ggctgcctca attgctggga gttcgattat     2280

caacaaaatg ttactggcaa acattgatcc ttttggtgcc acgccgttta ttgacccgga     2340

tctagattcc gtagatggat attcagaaaa atgtgtcatg aacaattact ttgggattgg     2400

attagatgca aaaatttcat tagaatttaa taataaaaga gaggagcacc ctgaaaaatg     2460

caggagccga actaaaaact tgatgtggta tggagtcctt ggaacccggg agttattaca     2520

gagatcgtac aagaatttag aacaaagggt tcaacttgag tgtgatgggc agtatattcc     2580

tcttcccagc ttgcaaggca tagccgtgtt gaacattccc agctatgctg gaggcactaa     2640

cttttggggt ggaactaaag aggatgatat atttgctgca ccatcctttg atgacaagat     2700

cctggaagtt gtagcaatat ttgatagcat gcaaatggca gtttcaaggg tcattaaact     2760

gcagcatcat cgaatagccc agtgccgtac agtgaaaatc actatatttg gtgacgaagg     2820

agtcccagtg caagtggatg gtgaagcgtg ggttcagcct ccagggatta tcaaaattgt     2880

gcacaaaaac agagcacaaa tgctaacaag ggacagagcc tttgagagca ctctgaaatc     2940

ttgggaagat aagcagaagt gtgattctgg taaaccagtt ctccgaaccc atttgtacat     3000

ccatcacgcc attgacttgg caacagaaga ggtgtcgcag atgcagctat gctcccaggc     3060

tgcagaggag ctcattacta ggatatgtga cgcagccaca attcactgtc ttttggagca     3120

agaactggcc catgctgtga atgcctgctc ccatgccctg aataaagcca acccaaggtg     3180

cccggagagt cttacaagag acactgccac tgaaatagcc atcaatgtga aggcgctgta     3240

taatgaaaca gaatctttgc tagttggcag ggttcctttg cagctggaat cgccacatga     3300

agagcgagta tccaatgcct tacactctgt ggaggtggaa ttacagaaac tgacagagat     3360

tccttggctt tattatatct tacacccaaa tgaggatgag gaacctccta tggattgcac     3420

caaaaggaac aacagaagca ccgtatttcg aatagtgcca aagtttaaaa aggaaaaggt     3480

tcagaagcag aagacaagtt cacagcctgt tcagaaatgg ggcacagagg aagttgctgc     3540

ttggctggat ctgctcaatt tgggagagta caaagatatc ttcatccgtc atgacatcag     3600

aggggctgaa cttttgcatc tggaaaggcg agatcttaag gatctgggga taccgaaagt     3660

gggtcatgtg aagcgaattc tccagggaat taaagagctt ggaaggagca ctccacagtc     3720

ggaggtgtaa tcatattggt gctatttctt ggaagagaag ttattgccac ttaatacaaa     3780

gtccttggaa gcaagtggct gttcttgtag ttttctgcat agataagtaa gcaccactga     3840

agcacctctg tggcttgata ttttgctgtg ggtgaaattt tgatttgagg tattagaaaa     3900

tatttttgtg ccgaacaata cattccacaa agccattttc tttttgtgca aacctgacat     3960

gttcaaatat attcacaatg gtaataaggt aggaggaatc tgagacgatt gcattgtcta     4020

aacagtggaa ttgcaaaatg tttactttcc atagatctgg tctgatggaa tgttcctact     4080

gtgcaactgc ataacaatat gtggttaaaa cttcctaggt ttcattacgg gggggcattg     4140

gccattttct taaaatcata ggttaggaga ctaaaatata aattaagttg tgatttgaat     4200

gtagattggt atcacctcca actcctagtg cttagtggtc aaatatgttg aaaacctttc     4260

caatactatg aatgaatgca aatcttaatg cacgatgaa                            4299


<210>  707
<211>  1220
<212>  PRT
<213>  Homo Sapiens

<400>  707

Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala 
            20                  25                  30          


Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro 
        35                  40                  45              


Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys 
    50                  55                  60                  


Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln 
65                  70                  75                  80  


Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr 
                85                  90                  95      


Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp 
            100                 105                 110         


Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr 
        115                 120                 125             


Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys 
    130                 135                 140                 


Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His 
                165                 170                 175     


Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys 
            180                 185                 190         


Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val 
        195                 200                 205             


Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn 
    210                 215                 220                 


Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp 
225                 230                 235                 240 


Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro 
                245                 250                 255     


Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu 
            260                 265                 270         


Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr 
        275                 280                 285             


Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys 
    290                 295                 300                 


Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly 
305                 310                 315                 320 


Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe 
                325                 330                 335     


Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg 
            340                 345                 350         


Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly 
        355                 360                 365             


Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg 
    370                 375                 380                 


Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu 
385                 390                 395                 400 


Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro 
                405                 410                 415     


Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser 
            420                 425                 430         


Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg 
        435                 440                 445             


Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu 
    450                 455                 460                 


Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser 
465                 470                 475                 480 


Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu 
                485                 490                 495     


Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala 
            500                 505                 510         


Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys 
        515                 520                 525             


Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala 
    530                 535                 540                 


Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala 
545                 550                 555                 560 


Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro 
                565                 570                 575     


Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu 
            580                 585                 590         


Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser 
        595                 600                 605             


Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu 
    610                 615                 620                 


Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp 
625                 630                 635                 640 


Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr 
                645                 650                 655     


Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly 
            660                 665                 670         


Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala 
        675                 680                 685             


Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala 
    690                 695                 700                 


Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile 
705                 710                 715                 720 


Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser 
                725                 730                 735     


Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr 
            740                 745                 750         


Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys 
        755                 760                 765             


Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser 
    770                 775                 780                 


Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser 
785                 790                 795                 800 


Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu 
                805                 810                 815     


Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys 
            820                 825                 830         


Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu 
        835                 840                 845             


Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys 
    850                 855                 860                 


Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu 
865                 870                 875                 880 


Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile 
                885                 890                 895     


Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr 
            900                 905                 910         


Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp 
        915                 920                 925             


Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln 
    930                 935                 940                 


Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu 
945                 950                 955                 960 


Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu 
                965                 970                 975     


Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met 
            980                 985                 990         


Gln Leu Cys Ser Gln Ala Ala Glu  Glu Leu Ile Thr Arg  Ile Cys Asp 
        995                 1000                 1005             


Ala Ala  Thr Ile His Cys Leu  Leu Glu Gln Glu Leu  Ala His Ala 
    1010                 1015                 1020             


Val Asn  Ala Cys Ser His Ala  Leu Asn Lys Ala Asn  Pro Arg Cys 
    1025                 1030                 1035             


Pro Glu  Ser Leu Thr Arg Asp  Thr Ala Thr Glu Ile  Ala Ile Asn 
    1040                 1045                 1050             


Val Lys  Ala Leu Tyr Asn Glu  Thr Glu Ser Leu Leu  Val Gly Arg 
    1055                 1060                 1065             


Val Pro  Leu Gln Leu Glu Ser  Pro His Glu Glu Arg  Val Ser Asn 
    1070                 1075                 1080             


Ala Leu  His Ser Val Glu Val  Glu Leu Gln Lys Leu  Thr Glu Ile 
    1085                 1090                 1095             


Pro Trp  Leu Tyr Tyr Ile Leu  His Pro Asn Glu Asp  Glu Glu Pro 
    1100                 1105                 1110             


Pro Met  Asp Cys Thr Lys Arg  Asn Asn Arg Ser Thr  Val Phe Arg 
    1115                 1120                 1125             


Ile Val  Pro Lys Phe Lys Lys  Glu Lys Val Gln Lys  Gln Lys Thr 
    1130                 1135                 1140             


Ser Ser  Gln Pro Val Gln Lys  Trp Gly Thr Glu Glu  Val Ala Ala 
    1145                 1150                 1155             


Trp Leu  Asp Leu Leu Asn Leu  Gly Glu Tyr Lys Asp  Ile Phe Ile 
    1160                 1165                 1170             


Arg His  Asp Ile Arg Gly Ala  Glu Leu Leu His Leu  Glu Arg Arg 
    1175                 1180                 1185             


Asp Leu  Lys Asp Leu Gly Ile  Pro Lys Val Gly His  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Gln Gly Ile Lys Glu  Leu Gly Arg Ser Thr  Pro Gln Ser 
    1205                 1210                 1215             


Glu Val  
    1220 


<210>  708
<211>  2864
<212>  DNA
<213>  Homo Sapiens

<400>  708
cctggcgaaa gcaagacgtg gaggttttac caggggttag tagcttcctc ttgctaactt       60

tttattggga caaaaggcaa gatggcacca ttctgttctc agatatttgt ctaaataaag      120

cccttttaat tttattttat ttttgttgtg ggattcttaa gcagataaga agaaaagaca      180

ccttcctagt gagcagctgc ccagctcctg ctcagttttg cctcggggta gcacctccag      240

ccacagaaag caagccggta agtctctcca ggtaggactt gctgcaaccc agctgctgga      300

ctgatctgaa acgggacttt gcatactctc cgaagtatgg tgagttggtg ctgacttcaa      360

agttgcctgg tgaaggaaga taaggtggat cgcagagact aaggggagag ggagaagccc      420

tgctcctctt ctccccacca aggcacaatg agcaacatct gtcagaggct ctgggagtac      480

ctagaaccct atctcccctg tttgtccacg gaggcagaca agtcaaccgt gattgaaaat      540

ccaggggccc tttgctctcc ccagtcacag aggcatggcc actactttgt ggctttgttt      600

gattaccagg ctcggactgc tgaggacttg agcttccgag caggtgacaa acttcaagtt      660

ctggacactt tgcatgaggg ctggtggttt gccagacact tggagaaaag acgagatggc      720

tccagtcagc aactacaagg ctatattcct tctaactacg tggctgagga cagaagccta      780

caggcagagc cgtggttctt tggagcaatc ggaagatcag atgcagagaa acaactatta      840

tattcagaaa acaagaccgg ttcctttcta atcagagaaa gtgaaagcca aaaaggagaa      900

ttctctcttt cagttttaga tggagcagtt gtaaaacact acagaattaa aagactggat      960

gaagggggat tttttctcac gcgaagaaga atcttttcaa cactgaacga atttgtgagc     1020

cactacacca agacaagtga cggcctgtgt gtcaagctgg ggaaaccatg cttaaagatc     1080

caggtcccag ctccatttga tttgtcgtat aaaaccgtgg accaatggga gatagaccgc     1140

aactccatac agcttctgaa gcgattggga tctggtcagt ttggcgaagt atgggaaggt     1200

ctgtggaaca ataccactcc agtagcagtg aaaacattaa aaccaggttc aatggatcca     1260

aatgacttcc tgagggaggc acagataatg aagaacctaa gacatccaaa gcttatccag     1320

ctttatgctg tttgcacttt agaagatcca atttatatta ttacagagtt gatgagacat     1380

ggaagtctgc aagaatatct ccaaaatgac actggatcaa aaatccatct gactcaacag     1440

gtagacatgg cggcacaggt tgcctctgga atggcctatc tggagtctcg gaactacatt     1500

cacagagatc tggctgccag aaatgtcctc gttggtgaac ataatatcta caaagtagca     1560

gattttggac ttgccagagt ttttaaggta gataatgaag acatctatga atctagacac     1620

gaaataaagc tgccggtgaa gtggactgcg cccgaagcca ttcgtagtaa taaattcagc     1680

attaagtccg atgtatggtc atttggaatc cttctttatg aaatcattac ttatggcaaa     1740

atgccttaca gtggtatgac aggtgcccag gtaatccaga tgttggctca aaactataga     1800

cttccgcaac catccaactg tccacagcaa ttttacaaca tcatgttgga gtgctggaat     1860

gcagagccta aggaacgacc tacatttgag acactgcgtt ggaaacttga agactatttt     1920

gaaacagact cttcatattc agatgcaaat aacttcataa gatgaacact ggagaagaat     1980

atcaaataat aaagtagcaa aacaaattca aataatccat tccaaaatac aatgttatca     2040

accaactgca caatcagttt atcctgacat attcaagtga taggataaag ttggccatgt     2100

attatgaaaa agattatttg tgcattttat tgactgggca acactgcagg acagtcaagg     2160

tgatatataa tttcctcact gcctggtaaa attaagcaca ctaaaccaag ttatttttct     2220

ttttaagaga tacttacatt tccatttatt gtttgaaatg tcgatcaaga gaatcaacag     2280

atgatagtcc aatttttact cagtgactgt tgtagcattt tcctgtttac tgattagagt     2340

ggttattcat tattcctcag attgctgaat cccatcaggc tgttattatg aaggaatttg     2400

attgctttgc tgcacagcag gacctgtgct ttgagatttt tttttctctt ttaaaatatc     2460

ctgtaactac aatgatggta aagccatgtt aaatgacttg attgtacttg gagtaattgc     2520

acattttttt ctatgcataa aaaaatgatg cagctgttga gaaaacgaag tctttttcat     2580

tttgcagaag gaaatgatgg aatttttctg tacttcagta tgtgtcaact gagagtcata     2640

tacattagtt ttaatctctt aatattgaga atcaggttgc aaaacggatg agttattatc     2700

tatggaaatg tgagaaatgt ctaatagccc ataaagtctg agaaataggt atcaaaatag     2760

tttaggaaaa tgagaggaga acagtaggat tgctgtggcc tagacttctg agtaattaat     2820

aaagaaaaag aagtaccctt tggcctacaa aaaaaaaaaa aaaa                      2864


<210>  709
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  709

Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210>  710
<211>  2937
<212>  DNA
<213>  Homo Sapiens

<400>  710
atgggcacgc gtctgccgct cgtcctgcgc cagctccgcc gcccgcccca gcccccgggc       60

cctccgcgcc gcctccgtgt gccctgtcgc gctagcagcg gcggcggcgg aggcggcggc      120

ggtggccggg agggcctgct tggacagcgg cggccgcagg atggccaggc ccggagcagc      180

tgcagccccg gcggccgaac gcccgcggcg cgggactcca tcgtcagaga agtcattcag      240

aattcaaaag aagttctaag tttattgcaa gaaaaaaacc ctgccttcaa gccggttctt      300

gcaattatcc aggcaggtga cgacaacttg atgcaggaaa tcaaccagaa tttggctgag      360

gaggctggtc tgaacatcac tcacatttgc ctccctccag atagcagtga agccgagatt      420

atagatgaaa tcttaaagat caatgaagat accagagtac atggccttgc ccttcagatc      480

tctgagaact tgtttagcaa caaagtcctc aatgccttga aaccagaaaa agatgtggat      540

ggagtaacag acataaacct ggggaagctg gtgcgagggg atgcccatga atgttttgtt      600

tcacctgttg ccaaagctgt aattgaactt cttgaaaaat caggtgtcaa cctagatgga      660

aagaagattt tggtagtggg ggcccatggg tctttggaag ctgctctaca atgcctgttc      720

cagagaaaag ggtccatgac aatgagcatc cagtggaaaa cacgccagct tcaaagcaag      780

cttcacgagg ctgacattgt ggtcctaggc tcacctaagc cagaagagat tccccttact      840

tggatacaac caggaactac tgttctcaac tgctcccatg acttcctgtc agggaaggtt      900

gggtgtggct ctccaagaat acattttggt ggactcattg aggaagatga tgtgattctc      960

cttgctgcag ctctgcgaat tcagaacatg gtcagtagtg gaaggagatg gcttcgtgaa     1020

cagcagcaca ggcggtggag acttcactgc ttgaaacttc agcctctctc ccctgtgcca     1080

agtgacattg agatttcaag aggacaaact ccaaaagctg tggatgtcct tgccaaggag     1140

attggattgc ttgcagatga aattgaaatc tatggcaaaa gcaaagccaa agtacgtttg     1200

tccgtgctag aaaggttaaa ggatcaagca gatggaaaat acgtcttagt tgctgggatc     1260

acacccaccc ctcttggaga agggaagagc acagtcacca tcgggcttgt gcaggctctg     1320

accgcacacc tgaatgtcaa ctcctttgcc tgcttgaggc agccttccca aggaccgacg     1380

tttggagtga aaggaggagc cgcgggtggt ggatatgccc aggtcatccc catggaggag     1440

ttcaaccttc acttgactgg agacatccac gccatcaccg ctgccaataa cttgctggct     1500

gccgccatcg acacgaggat tcttcatgaa aacacgcaaa cagataaggc tctgtataat     1560

cggctggttc ctttagtgaa tggtgtcaga gaattttcag aaattcagct tgctcggcta     1620

aaaaaactgg gaataaataa gactgatccg agcacactga cagaagagga agtgagtaaa     1680

tttgcccgtc tcgacatcga cccatctacc atcacgtggc agagagtatt ggatacaaat     1740

gaccgatttc tacgaaaaat aaccatcggg cagggaaaca cagagaaggg ccattaccgg     1800

caggcgcagt ttgacatcgc agtggccagc gagatcatgg cggtgctggc cctgacggac     1860

agcctcgcag acatgaaggc acggctggga aggatggtgg tggccagtga caaaagcggg     1920

cagcctgtga cagcagatga tttgggggtg acaggtgctt tgacagtttt gatgaaagat     1980

gcaataaaac caaacctgat gcagaccctg gaagggacac ctgtgttcgt gcatgcgggc     2040

ccttttgcta acattgctca cggcaactct tcagtgttgg ctgataaaat tgccctgaaa     2100

ctggttggtg aagaaggatt tgtagtgacc gaagctggct ttggtgctga catcggaatg     2160

gagaaattct tcaacatcaa gtgccgagct tccggcttgg tgcccaacgt ggttgtgtta     2220

gtggcaacgg tgcgagctct gaagatgcat ggaggcgggc caagtgtaac ggctggtgtt     2280

cctcttaaga aagaatatac agaggagaac atccagctgg tggcagacgg ctgctgtaac     2340

ctccagaagc aaattcagat cactcagctc tttggggttc ccgttgtggt ggctctgaat     2400

gtcttcaaga ccgacacccg cgctgagatt gacttggtgt gtgagcttgc aaagcgggct     2460

ggtgcctttg atgcagtccc ctgctatcac tggtccgttg gtggaaaagg atcggtggac     2520

ttggctcggg ctgtgagaga ggctgcgagt aaaagaagcc gattccagtt cctgtatgat     2580

gttcaggttc caattgtgga caagataagg accattgctc aggctgtcta tggagccaaa     2640

gatattgaac tctctcctga ggcacaagcc aaaatagatc gttacactca acagggtttt     2700

ggaaatttgc ccatctgcat ggcaaagacc cacctttctc tatctcacca acctgacaaa     2760

aaaggtgtgc caagggactt catcttacct atcagtgacg tccgggccag cataggcgct     2820

gggttcattt accctttggt cggaacgatg agcaccatgc caggactgcc cacccggccc     2880

tgcttttatg acatagatct tgataccgaa acagaacaag ttaaaggctt gttctaa        2937


<210>  711
<211>  978
<212>  PRT
<213>  Homo Sapiens

<400>  711

Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser Pro 
            260                 265                 270         


Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr Val 
        275                 280                 285             


Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly Ser 
    290                 295                 300                 


Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile Leu 
305                 310                 315                 320 


Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg Arg 
                325                 330                 335     


Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu Lys 
            340                 345                 350         


Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg Gly 
        355                 360                 365             


Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu Leu 
    370                 375                 380                 


Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg Leu 
385                 390                 395                 400 


Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val Leu 
                405                 410                 415     


Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr Val 
            420                 425                 430         


Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn Ser 
        435                 440                 445             


Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val Lys 
    450                 455                 460                 


Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu Glu 
465                 470                 475                 480 


Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala Asn 
                485                 490                 495     


Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn Thr 
            500                 505                 510         


Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn Gly 
        515                 520                 525             


Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu Gly 
    530                 535                 540                 


Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser Lys 
545                 550                 555                 560 


Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg Val 
                565                 570                 575     


Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln Gly 
            580                 585                 590         


Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala Val 
        595                 600                 605             


Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp 
    610                 615                 620                 


Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly 
625                 630                 635                 640 


Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val 
                645                 650                 655     


Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly 
            660                 665                 670         


Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly 
        675                 680                 685             


Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu 
    690                 695                 700                 


Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met 
705                 710                 715                 720 


Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn 
                725                 730                 735     


Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly 
            740                 745                 750         


Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu 
        755                 760                 765             


Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln 
    770                 775                 780                 


Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn 
785                 790                 795                 800 


Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu 
                805                 810                 815     


Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser 
            820                 825                 830         


Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala 
        835                 840                 845             


Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro 
    850                 855                 860                 


Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys 
865                 870                 875                 880 


Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr 
                885                 890                 895     


Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu 
            900                 905                 910         


Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile 
        915                 920                 925             


Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr 
    930                 935                 940                 


Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro 
945                 950                 955                 960 


Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly 
                965                 970                 975     


Leu Phe 
        


<210>  712
<211>  1848
<212>  DNA
<213>  Homo Sapiens

<400>  712
cacgctgcgc ccggcgccgc agggtgggcg gcgaggcact cacgaggggg acgctgaggg       60

cttccgcgcg ggccacccgg gtcaagcgcg ctccgccggg aaacttctgc gggcgccggg      120

ctgaagctcc gggcagggct gggaaggaaa ggaaatacca aaatatttgc agactggatc      180

caaatcagga gcccagatga acttaaagaa gcgagcatgg gattcttagt ttttcaagat      240

ccgtacacac gaagccttta atcagcatca actccagtgt ccgttttctc tggttttgtg      300

aagactgcac aaaactctca tgatggagaa ccaaaggact tagttacctg tttcagtgtc      360

atctaaagtc aactgaaaag tgaagcaggc agtaatacag ccatggaaag aaattcaagt      420

ttatggaaga acctaataga tgaacaccca gtctgcacaa cctggaagca agaggccgaa      480

ggagccattt atcatcttgc cagtatttta tttgtagtag gtttcatggg tggcagtgga      540

ttcttcgggc tcctttatgt cttcagtttg ctggggttgg gttttctctg ttctgctgtc      600

tgggcttggg tagatgtctg tgcagctgac atattttcct ggaattttgt actgtttgtc      660

atctgcttca tgcaatttgt tcatattgca tatcaagttc gcagcataac ctttgcccga      720

gaattccaag tgttgtacag ctcccttttc cagcccctgg ggatctcttt gcctgtcttc      780

agaacgattg ctttgagctc tgaagtggtt actttggaaa aggaacactg ttatgccatg      840

caggggaaaa cttccattga taaactctcc ttgcttgttt caggaaggat cagagtgaca      900

gttgatggcg aatttctgca ttacattttc ccccttcagt tcctggattc tcctgagtgg      960

gattcactga gacccacaga ggaaggcatt tttcaggtaa ccctcactgc agaaactgat     1020

tgtcgatatg tgtcttggag gagaaagaaa ttatatctgc tctttgctca gcatcgctac     1080

atctcccgcc ttttttcagt gctaattggc agtgacattg cagataaact ctatgccttg     1140

aatgacaggg tatatatagg aaaaagatat cactatgata ttcggctacc caacttctat     1200

caaatgtcaa ctccagaaat acgcagatca cccctgacac aacattttca gaattccaga     1260

cgatactgtg ataaatgaca tcaaagtctg aaatttataa gtataaaaaa agactctctc     1320

ttcatcattc cccagtgaaa tagcaaaata caaaaaaaga gctccctaat gtttttataa     1380

atcaaattca gaagcgagat gccattgcca actgttttat tcctttcaac aactgcattg     1440

tgaataaact ttacaaattt ttcttgtatt tctcattgtt ataattgggg agggggtgga     1500

taactatggg cagtttgccc ttttctgcat caaaactggg agaatgaaat tccactttct     1560

caattctttt ctcacattta ctcaaatgca ttgtcttgcc ctatagactc aggagttgct     1620

tctcaagaaa gagccagcaa gtattctcag cctgagggtg ggttgctact gtccacatag     1680

gcatttccgg aattcacttt tttgctacaa cctccagtga aagcaattat ttattttaaa     1740

tgtgcagtta cttgatgcga ctaaaaagta gaataaatgc aagagataat aatatgtgaa     1800

tcttgaagcc tattttattg ctacaaataa aataacattt aaaaagaa                  1848


<210>  713
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  713

Met Glu Arg Asn Ser Ser Leu Trp Lys Asn Leu Ile Asp Glu His Pro 
1               5                   10                  15      


Val Cys Thr Thr Trp Lys Gln Glu Ala Glu Gly Ala Ile Tyr His Leu 
            20                  25                  30          


Ala Ser Ile Leu Phe Val Val Gly Phe Met Gly Gly Ser Gly Phe Phe 
        35                  40                  45              


Gly Leu Leu Tyr Val Phe Ser Leu Leu Gly Leu Gly Phe Leu Cys Ser 
    50                  55                  60                  


Ala Val Trp Ala Trp Val Asp Val Cys Ala Ala Asp Ile Phe Ser Trp 
65                  70                  75                  80  


Asn Phe Val Leu Phe Val Ile Cys Phe Met Gln Phe Val His Ile Ala 
                85                  90                  95      


Tyr Gln Val Arg Ser Ile Thr Phe Ala Arg Glu Phe Gln Val Leu Tyr 
            100                 105                 110         


Ser Ser Leu Phe Gln Pro Leu Gly Ile Ser Leu Pro Val Phe Arg Thr 
        115                 120                 125             


Ile Ala Leu Ser Ser Glu Val Val Thr Leu Glu Lys Glu His Cys Tyr 
    130                 135                 140                 


Ala Met Gln Gly Lys Thr Ser Ile Asp Lys Leu Ser Leu Leu Val Ser 
145                 150                 155                 160 


Gly Arg Ile Arg Val Thr Val Asp Gly Glu Phe Leu His Tyr Ile Phe 
                165                 170                 175     


Pro Leu Gln Phe Leu Asp Ser Pro Glu Trp Asp Ser Leu Arg Pro Thr 
            180                 185                 190         


Glu Glu Gly Ile Phe Gln Val Thr Leu Thr Ala Glu Thr Asp Cys Arg 
        195                 200                 205             


Tyr Val Ser Trp Arg Arg Lys Lys Leu Tyr Leu Leu Phe Ala Gln His 
    210                 215                 220                 


Arg Tyr Ile Ser Arg Leu Phe Ser Val Leu Ile Gly Ser Asp Ile Ala 
225                 230                 235                 240 


Asp Lys Leu Tyr Ala Leu Asn Asp Arg Val Tyr Ile Gly Lys Arg Tyr 
                245                 250                 255     


His Tyr Asp Ile Arg Leu Pro Asn Phe Tyr Gln Met Ser Thr Pro Glu 
            260                 265                 270         


Ile Arg Arg Ser Pro Leu Thr Gln His Phe Gln Asn Ser Arg Arg Tyr 
        275                 280                 285             


Cys Asp Lys 
    290     


<210>  714
<211>  1485
<212>  DNA
<213>  Homo Sapiens

<400>  714
tcagccaatt agagctccag ttgtcactcc tacccacact gggcctgggg gtgaagggaa       60

gtgtttatta ggggtacatg tgaagccgtc cagaagtgtc agagtctttg tagctttgaa      120

agtcacctag gttatttggg catgctctcc tgagtcctct gctagttaag ctctctgaaa      180

agaaggtggc agacccggtt tgctgatcgc cccagggatc aggaggctga tcccaaagtt      240

gtcagatgga gagtaaatac aaggagatac tcttgctaac aggcctggat aacatcactg      300

atgaggaact ggataggttt aagttctttc tttcagacga gtttaatatt gccacaggca      360

aactacatac tgcaaacaga atacaagtag ctaccttgat gattcaaaat gctggggcgg      420

tgtctgcagt gatgaagacc attcgtattt ttcagaagtt gaattatatg cttttggcaa      480

aacgtcttca ggaggagaag gagaaagttg ataagcaata caaatcggta acaaaaccaa      540

agccactaag tcaagctgaa atgagtcctg ctgcatctgc agccatcaga aatgatgtcg      600

caaagcaacg tgctgcacca aaagtctctc ctcatgttaa gcctgaacag aaacagatgg      660

tggcccagca ggaatctatc agagaagggt ttcagaagcg ctgtttgcca gttatggtac      720

tgaaagcaaa gaagcccttc acgtttgaga cccaagaagg caagcaggag atgtttcatg      780

ctacagtggc tacagaaaag gaattcttct ttgtaaaagt ttttaataca ctgctgaaag      840

ataaattcat tccaaagaga ataattataa tagcaagata ttatcggcac agtggtttct      900

tagaggtaaa tagcgcctca cgtgtgttag atgctgaatc tgaccaaaag gttaatgtcc      960

cgctgaacat tatcagaaaa gctggtgaaa ccccgaagat caacacgctt caaactcagc     1020

cccttggaac aattgtgaat ggtttgtttg tagtccagaa ggtaacagaa aagaagaaaa     1080

acatattatt tgacctaagt gacaacactg ggaaaatgga agtactgggg gttagaaacg     1140

aggacacaat gaaatgtaag gaaggagata aggttcgact tacattcttc acactgtcaa     1200

aaaatggaga aaaactacag ctgacatctg gagttcatag caccataaag gttattaagg     1260

ccaaaaaaaa aacatagaga agtaaaaagg accaattcaa gccaactggt ctaagcagca     1320

tttaattgaa gaatatgtga tacagcctct tcaatcagat tgtaagttac ctgaaagctg     1380

cagttcacag gctcctctct ccaccaaatt aggatagaat aattgctgga taaacaaatt     1440

cagaatatca acagatgatc acaataaaca tctgtttctc attcc                     1485


<210>  715
<211>  343
<212>  PRT
<213>  Homo Sapiens

<400>  715

Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      


Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     


Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Thr 
            340             


<210>  716
<211>  2548
<212>  DNA
<213>  Homo Sapiens

<400>  716
agcatggaga gaaaatttat gtccttgcaa ccatccatct ccgtatcaga aatggaacca       60

aatggcacct tcagcaataa caacagcagg aactgcacaa ttgaaaactt caagagagaa      120

tttttcccaa ttgtatatct gataatattt ttctggggag tcttgggaaa tgggttgtcc      180

atatatgttt tcctgcagcc ttataagaag tccacatctg tgaacgtttt catgctaaat      240

ctggccattt cagatctcct gttcataagc acgcttccct tcagggctga ctattatctt      300

agaggctcca attggatatt tggagacctg gcctgcagga ttatgtctta ttccttgtat      360

gtcaacatgt acagcagtat ttatttcctg accgtgctga gtgttgtgcg tttcctggca      420

atggttcacc cctttcggct tctgcatgtc accagcatca ggagtgcctg gatcctctgt      480

gggatcatat ggatccttat catggcttcc tcaataatgc tcctggacag tggctctgag      540

cagaacggca gtgtcacatc atgcttagag ctgaatctct ataaaattgc taagctgcag      600

accatgaact atattgcctt ggtggtgggc tgcctgctgc catttttcac actcagcatc      660

tgttatctgc tgatcattcg ggttctgtta aaagtggagg tcccagaatc ggggctgcgg      720

gtttctcaca ggaaggcact gaccaccatc atcatcacct tgatcatctt cttcttgtgt      780

ttcctgccct atcacacact gaggaccgtc cacttgacga catggaaagt gggtttatgc      840

aaagacagac tgcataaagc tttggttatc acactggcct tggcagcagc caatgcctgc      900

ttcaatcctc tgctctatta ctttgctggg gagaatttta aggacagact aaagtctgca      960

ctcagaaaag gccatccaca gaaggcaaag acaaagtgtg ttttccctgt tagtgtgtgg     1020

ttgagaaagg aaacaagagt ataaggagct cttagatgag acctgttctt gtatccttgt     1080

gtccatcttc attcactcat agtctccaaa tgactttgta tttacatcac tcccaacaaa     1140

tgttgattct taatatttag ttgaccatta cttttgttaa taagacctac ttcaaaaatt     1200

ttattcagtg tattttcagt tgttgagtct taatgaggga tacaggagga aaaatcccta     1260

ctagagtcct gtgggctgaa atatcagact gggaaaaaat gcaaagcaca ttggatccta     1320

cttttcttca gatattgaac cagatctctg gcccatcagg ctttctaaat tcttcaaaag     1380

agccacaact tccccagctt ctccagctcc cctgtcctct tcaatccctt gagatatagc     1440

caactaacga cgctactgga agccccagag cagaaaagaa gcacatccta agattcaggg     1500

aaagactaac tgtgaaaagg aaggctgtcc tataacaaag cagcatcaag tcccaagtaa     1560

ggacagtgag agaaaagggg gagaaggatt ggagcaaaag agaactggca ataagtaggg     1620

gaaggaagaa tttcattttg cattgggaga gaggttctaa cacactgaag gcaaccctat     1680

ttctactgtt tctctcttgc cagggtatta ggaaggacag gaaaagtagg aggaggatct     1740

ggggcattgc cctaggaaat gaaagaattg tgtatagaat ggaaggggga tcatcaagga     1800

catgtatctc aaattttctt tgagatgcag gttagttgac cttgctgcag ttctccttcc     1860

cattaattca ttgggatgga agccaaaaat aaaagaggtg cctctgagga ttagggttga     1920

gcactcaagg gaaagatgga gtagagggca aatagcaaaa gttgttgcac tcctgaaatt     1980

ctattaacat ttccgcagaa gatgagtagg gagatgctgc cttccctttt gagatagtgt     2040

agaaaaacac tagatagtgt gagaggttcc tttctgtcca ctgaaacaag gctaaggata     2100

ctaccaacta ctatcaccat gaccattgta ctgacaacaa ttgaatgcag tctccctgca     2160

gggcagatta tgccaggcac tttacatttg ttgatcccat ttgacattca caccaaagct     2220

ctgagttcca ttttacagct gaagaaattg aagcttagag aaattaagaa gcttgtttaa     2280

gtttacacag ctagtaagag ttttaaaaat ctctgtgcag aagtgttggc tgggtgctct     2340

ccccaccact acccttgtaa acttccagga agattggttg aaagtctgaa taaaagctgt     2400

cctttcctac caatttcctc cccctcctca ctctcacaag aaaaccaaaa gtttctcttc     2460

agagttgttg actcatagta cagtaaaggg tggaggtgat atggcattct gaaagtaggg     2520

agggactaag tcagtcatca tactaaac                                        2548


<210>  717
<211>  346
<212>  PRT
<213>  Homo Sapiens

<400>  717

Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu 
1               5                   10                  15      


Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr 
            20                  25                  30          


Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile 
        35                  40                  45              


Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu 
    50                  55                  60                  


Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu 
65                  70                  75                  80  


Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp 
                85                  90                  95      


Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg 
            100                 105                 110         


Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe 
        115                 120                 125             


Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe 
    130                 135                 140                 


Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly 
145                 150                 155                 160 


Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser 
                165                 170                 175     


Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu 
            180                 185                 190         


Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val 
        195                 200                 205             


Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile 
    210                 215                 220                 


Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val 
225                 230                 235                 240 


Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe 
                245                 250                 255     


Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr 
            260                 265                 270         


Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val 
        275                 280                 285             


Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu 
    290                 295                 300                 


Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu 
305                 310                 315                 320 


Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val 
                325                 330                 335     


Ser Val Trp Leu Arg Lys Glu Thr Arg Val 
            340                 345     


<210>  718
<211>  5478
<212>  DNA
<213>  Homo Sapiens

<400>  718
agtttggtct ggagcagctg aaaccggttt gagcgtggct gcttcctgcc gctcgacgcc       60

gcggcaggcc gcctgggggg agcgctggcg aggcacggac ggcgggcgcc cggtacctct      120

gcccgcggtc ctcgctctcg ggcggggcgg cggcgacgcg gacctgcgga ctagcgaacc      180

cggagcacga catcataaaa taaatccatc agaatgacac cttctcaggt tgcctttgaa      240

ataagaggaa ctcttttacc aggagaagtt tttgcgatat gtggaagctg tgatgctttg      300

ggaaactgga atcctcaaaa tgctgtggct cttcttccag agaatgacac aggtgaaagc      360

atgctatgga aagcaaccat tgtactcagt agaggagtat cagttcagta tcgctacttc      420

aaagggtact ttttagaacc aaagactatc ggtggtccat gtcaagtgat agttcacaag      480

tgggagactc atctacaacc acgatcaata acccctttag aaagcgaaat tattattgac      540

gatggacaat ttggaatcca caatggtgtt gaaactctgg attctggatg gctgacatgt      600

cagactgaaa taagattacg tttgcattat tctgaaaaac ctcctgtgtc aataaccaag      660

aaaaaattaa aaaaatctag atttagggtg aagctgacac tagaaggcct ggaggaagat      720

gacgatgata gggtatctcc cactgtactc cacaaaatgt ccaatagctt ggagatatcc      780

ttaataagcg acaatgagtt caagtgcagg cattcacagc cggagtgtgg ttatggcttg      840

cagcctgatc gttggacaga gtacagcata cagacgatgg aaccagataa cctggaacta      900

atctttgatt ttttcgaaga agatctcagt gagcacgtag ttcagggtga tgcccttcct      960

ggacatgtgg gtacagcttg tctcttatca tccaccattg ctgagagtgg aaagagtgct     1020

ggaattctta ctcttcccat catgagcaga aattcccgga aaacaatagg caaagtgaga     1080

gttgactata taattattaa gccattacca ggatacagtt gtgacatgaa atcttcattt     1140

tccaagtatt ggaagccaag aataccattg gatgttggcc atcgaggtgc aggaaactct     1200

acaacaactg cccagctggc taaagttcaa gaaaatacta ttgcttcttt aagaaatgct     1260

gctagtcatg gtgcagcctt tgtagaattt gacgtacacc tttcaaagga ctttgtgccc     1320

gtggtatatc atgatcttac ctgttgtttg actatgaaaa agaaatttga tgctgatcca     1380

gttgaattat ttgaaattcc agtaaaagaa ttaacatttg accaactcca gttgttaaag     1440

ctcactcatg tgactgcact gaaatctaag gatcggaaag aatctgtggt tcaggaggaa     1500

aattcctttt cagaaaatca gccatttcct tctcttaaga tggttttaga gtctttgcca     1560

gaagatgtag ggtttaacat tgaaataaaa tggatctgcc agcaaaggga tggaatgtgg     1620

gatggtaact tatcaacata ttttgacatg aatctgtttt tggatataat tttaaaaact     1680

gttttagaaa attctgggaa gaggagaata gtgttttctt catttgatgc agatatttgc     1740

acaatggttc ggcaaaagca gaacaaatat ccgatactat ttttaactca aggaaaatct     1800

gagatttatc ctgaactcat ggacctcaga tctcggacaa cccccattgc aatgagcttt     1860

gcacagtttg aaaatctact ggggataaat gtacatactg aagacttgct cagaaaccca     1920

tcctatattc aagaggcaaa agctaaggga ctagtcatat tctgctgggg tgatgatacc     1980

aatgatcctg aaaacagaag gaaattgaag gaacttggag ttaatggtct aatttatgat     2040

aggatatatg attggatgcc tgaacaacca aatatattcc aagtggagca attggaacgc     2100

ctgaagcagg aattgccaga gcttaagagc tgtttgtgtc ccactgttag ccgctttgtt     2160

ccctcatctt tgtgtgggga gtctgatatc catgtggatg ccaacggcat tgataacgtg     2220

gagaatgctt agtttttatt gcacagaggt cattttgggg gcgtgcaccg ctgttctggg     2280

tattcatttt tcatcactga gcattgttga tctatgcctt ttgggcttct cagttcaatg     2340

aagcaataat gaagtattta actctttcac tacagttctt gcaagtatgc tatttaaatt     2400

acttggccag gtataattgc cagtcagtct ctttatagtg agaaaattta ttggttagta     2460

atataaatat tttaaactaa atatataaat ctataatgtt aaacatatgt tcattaaaag     2520

catagcactt tgaaattaac tatataaata gctcatattt acacttacag cttttcattt     2580

gatcaggtct gaaatcttta gcacttaagg aaaatgacta tgcataatta tacctgacca     2640

tgaaaaaaat aagtacctca aatgcatgca tttgcactgg tgattccaac tgcacaaatc     2700

tttgtgccat cttgtatata ggtatttttt acatgggttg acatgcacac aacaccattt     2760

tcattcagta tgaaccttga ggctgctgcc atttttccac ttaaccaaac cagcctgaag     2820

gtgaacctcg aaacttgttt cataaatctt tcaaaagttg ttttacatca atgttaaaat     2880

ttcaaaatgc tgcagggtaa tttaatgtat aaaatattag taagaaaaag tatgtattgc     2940

atacttagta gaatagatca caacatacaa attcaattca gtgcatgctt taggtgttaa     3000

gcatgagatt gtacatgttt actgttaggt ccttgcatct gtggtgctag gtgagtatga     3060

gaagatgtca aggactggac gtattttgtt gcctaaaaaa aaaaggctgt ttgtaggcgt     3120

tttaaatatg cttattttgt gtgtctctca ctacctatta cacactgttg ctttgtgggt     3180

ttgttttgta tgtgcgtgtg ttatacagta gttaaatttc catgcagaaa aataaatgtc     3240

ctgaattttc atattagtat tctttattgt atatcatgca tgtaatttat ttagaaatgt     3300

aggtcttact aaatgtatat gcatgtattt cagattatac taggatttct tggattagaa     3360

gcagattgtg ttaactgtaa cttaaagaat gaatgttaaa taaaatgata cagatttatt     3420

ttcttcatta caaaatgaaa tttcaagaag gtgttacttt tgtagaatgg ttttataata     3480

tgacaagaaa ttttaatata gtgtctaccc taaagggatg gcttatttgc atctaccttt     3540

tactgcatgt ttttcacaag gcagtttatt catatattga catattttgg tagtagctga     3600

gaacctaaga cttgaaatta tacattgtgt agtatttttt aagctaagca atgcaatttt     3660

ggtcagatct tatttgtgtg aagataggct ctgaaatcct atggtattgc gtttgtaacg     3720

ttgatattaa tgcaaaatag tttaggaaat ggagtcttct gcaagggttc tgtatacttt     3780

tcccacattg tatgagattt tccaaaattt tggtgtgaat tgggcacttt tggaaaactc     3840

ctgaaaaaga attagtttcc ttcatctgca gacctttgtc caatacggtt accatttctt     3900

tatagtaact cgattagcca tatatgtttg tttctagtcc tgctcctttg ctcctctcct     3960

atgccttccc agtgctggct ccattttgaa gactcaagga cagaggggaa gcagatcata     4020

aagagaaaaa ggagacagaa gaaaggatga aggaaggagg tcatggggag tgtggcttct     4080

gagcagttta gttgctgggg agagcagaca gtcactgcct acaatacaga cagaaccttc     4140

ctgctcactt tctgtcctat ctcttcctga ccttatgaac cagtgttagt agatgattaa     4200

aacatgacaa gcaatggctc cttattttca caggactaag tccgggcctt cgtatcacta     4260

gctgttgcct tttacaccct gcttcagcca ccctgtccct gtcattggcc ctggacttcc     4320

tctctgtgcc cgtgtgtcct ctgcctggga gccctctcct cccatagtca ctttctctct     4380

gccaaactca tttcttcttg tgcccaagac ctctctcctg agcccttgtg gaaacttcag     4440

gaaggatgaa tccgtctttg tgctccacgg ctcgtacctt gatcaggctg tgcatcacag     4500

taattctgtt ctaggtaggc agagttgatc tttgtctcat ctgccaggct gcaggctctt     4560

caagggcagg gaccttgtca tagtcatttt tattttcaca gtgcttggaa catggtggaa     4620

aatgaatgtt ggaattattg gagtaatata atttgtatca aatgtccttt tgaattaaga     4680

gatttagtta tgtttactaa gaatgtaaac tttgaattgg tttgcatttt aacaattagg     4740

atggtttatt gatgtgaatt ttgaaatgta gaggtataat gttaaattat tttatacttt     4800

atggaaatca agtgaaatgt ttgaaaaaat gccgccatta tcctctggta ttttctactc     4860

tctggaatta tgtgctgtaa atgatcggct gtaaatgtga ggcacaccac ccacccctgt     4920

gtggaaagtg ttgtggcgct tcctgccacc cacccacctc tctgccgttg ctccttgtga     4980

cacttgtctg tcgtctccca tccaaactcc aagcttacag ctacctcagt actgctttgc     5040

ttgtctgaaa cacctccttt gccttccttc agtgtcccgc tcaggtgcag cctcctccct     5100

aaagctcatc tcagcttttg atctgaatga tgatggaaac atgcagacag cctctcagtc     5160

ttactattta atgttgtagc tgggaaaaaa cccagagagg ttaactgata tactgggttg     5220

ggactaggat gtgggttttg tgactctgaa tcccatgttc tcaaactacg ctgccttccg     5280

aagtctggca tttgttagct catgcttcct tgtagtccag cttcttatgt gcctgttata     5340

ttctccagta agattgtaag ccccttaagg gcagggacgt ctttgcatct ctagcactgc     5400

tatagtgttc tatccttagt tatgaactag ataaataaat ggtggtggca acaatcctaa     5460

aaaaaaaaaa aaaaaaaa                                                   5478


<210>  719
<211>  672
<212>  PRT
<213>  Homo Sapiens

<400>  719

Met Thr Pro Ser Gln Val Ala Phe Glu Ile Arg Gly Thr Leu Leu Pro 
1               5                   10                  15      


Gly Glu Val Phe Ala Ile Cys Gly Ser Cys Asp Ala Leu Gly Asn Trp 
            20                  25                  30          


Asn Pro Gln Asn Ala Val Ala Leu Leu Pro Glu Asn Asp Thr Gly Glu 
        35                  40                  45              


Ser Met Leu Trp Lys Ala Thr Ile Val Leu Ser Arg Gly Val Ser Val 
    50                  55                  60                  


Gln Tyr Arg Tyr Phe Lys Gly Tyr Phe Leu Glu Pro Lys Thr Ile Gly 
65                  70                  75                  80  


Gly Pro Cys Gln Val Ile Val His Lys Trp Glu Thr His Leu Gln Pro 
                85                  90                  95      


Arg Ser Ile Thr Pro Leu Glu Ser Glu Ile Ile Ile Asp Asp Gly Gln 
            100                 105                 110         


Phe Gly Ile His Asn Gly Val Glu Thr Leu Asp Ser Gly Trp Leu Thr 
        115                 120                 125             


Cys Gln Thr Glu Ile Arg Leu Arg Leu His Tyr Ser Glu Lys Pro Pro 
    130                 135                 140                 


Val Ser Ile Thr Lys Lys Lys Leu Lys Lys Ser Arg Phe Arg Val Lys 
145                 150                 155                 160 


Leu Thr Leu Glu Gly Leu Glu Glu Asp Asp Asp Asp Arg Val Ser Pro 
                165                 170                 175     


Thr Val Leu His Lys Met Ser Asn Ser Leu Glu Ile Ser Leu Ile Ser 
            180                 185                 190         


Asp Asn Glu Phe Lys Cys Arg His Ser Gln Pro Glu Cys Gly Tyr Gly 
        195                 200                 205             


Leu Gln Pro Asp Arg Trp Thr Glu Tyr Ser Ile Gln Thr Met Glu Pro 
    210                 215                 220                 


Asp Asn Leu Glu Leu Ile Phe Asp Phe Phe Glu Glu Asp Leu Ser Glu 
225                 230                 235                 240 


His Val Val Gln Gly Asp Ala Leu Pro Gly His Val Gly Thr Ala Cys 
                245                 250                 255     


Leu Leu Ser Ser Thr Ile Ala Glu Ser Gly Lys Ser Ala Gly Ile Leu 
            260                 265                 270         


Thr Leu Pro Ile Met Ser Arg Asn Ser Arg Lys Thr Ile Gly Lys Val 
        275                 280                 285             


Arg Val Asp Tyr Ile Ile Ile Lys Pro Leu Pro Gly Tyr Ser Cys Asp 
    290                 295                 300                 


Met Lys Ser Ser Phe Ser Lys Tyr Trp Lys Pro Arg Ile Pro Leu Asp 
305                 310                 315                 320 


Val Gly His Arg Gly Ala Gly Asn Ser Thr Thr Thr Ala Gln Leu Ala 
                325                 330                 335     


Lys Val Gln Glu Asn Thr Ile Ala Ser Leu Arg Asn Ala Ala Ser His 
            340                 345                 350         


Gly Ala Ala Phe Val Glu Phe Asp Val His Leu Ser Lys Asp Phe Val 
        355                 360                 365             


Pro Val Val Tyr His Asp Leu Thr Cys Cys Leu Thr Met Lys Lys Lys 
    370                 375                 380                 


Phe Asp Ala Asp Pro Val Glu Leu Phe Glu Ile Pro Val Lys Glu Leu 
385                 390                 395                 400 


Thr Phe Asp Gln Leu Gln Leu Leu Lys Leu Thr His Val Thr Ala Leu 
                405                 410                 415     


Lys Ser Lys Asp Arg Lys Glu Ser Val Val Gln Glu Glu Asn Ser Phe 
            420                 425                 430         


Ser Glu Asn Gln Pro Phe Pro Ser Leu Lys Met Val Leu Glu Ser Leu 
        435                 440                 445             


Pro Glu Asp Val Gly Phe Asn Ile Glu Ile Lys Trp Ile Cys Gln Gln 
    450                 455                 460                 


Arg Asp Gly Met Trp Asp Gly Asn Leu Ser Thr Tyr Phe Asp Met Asn 
465                 470                 475                 480 


Leu Phe Leu Asp Ile Ile Leu Lys Thr Val Leu Glu Asn Ser Gly Lys 
                485                 490                 495     


Arg Arg Ile Val Phe Ser Ser Phe Asp Ala Asp Ile Cys Thr Met Val 
            500                 505                 510         


Arg Gln Lys Gln Asn Lys Tyr Pro Ile Leu Phe Leu Thr Gln Gly Lys 
        515                 520                 525             


Ser Glu Ile Tyr Pro Glu Leu Met Asp Leu Arg Ser Arg Thr Thr Pro 
    530                 535                 540                 


Ile Ala Met Ser Phe Ala Gln Phe Glu Asn Leu Leu Gly Ile Asn Val 
545                 550                 555                 560 


His Thr Glu Asp Leu Leu Arg Asn Pro Ser Tyr Ile Gln Glu Ala Lys 
                565                 570                 575     


Ala Lys Gly Leu Val Ile Phe Cys Trp Gly Asp Asp Thr Asn Asp Pro 
            580                 585                 590         


Glu Asn Arg Arg Lys Leu Lys Glu Leu Gly Val Asn Gly Leu Ile Tyr 
        595                 600                 605             


Asp Arg Ile Tyr Asp Trp Met Pro Glu Gln Pro Asn Ile Phe Gln Val 
    610                 615                 620                 


Glu Gln Leu Glu Arg Leu Lys Gln Glu Leu Pro Glu Leu Lys Ser Cys 
625                 630                 635                 640 


Leu Cys Pro Thr Val Ser Arg Phe Val Pro Ser Ser Leu Cys Gly Glu 
                645                 650                 655     


Ser Asp Ile His Val Asp Ala Asn Gly Ile Asp Asn Val Glu Asn Ala 
            660                 665                 670         


<210>  720
<211>  6050
<212>  DNA
<213>  Homo Sapiens

<400>  720
atccatggca cggagcggcg gcggcggcgg cagcaggagc ccggcgcgat ccgctaggtc       60

ccagcccagc gcccagcgag caggcgacgc ggaggggccg ggcctccagt gtcccgaggg      120

ccgggcgctg agactccggc cgcgcagctg ggagctgccc gcgctgcgct gacagccgcg      180

ccgacgtcct ccccgccggg gcgctcgcag gacatgcccc cggggcgcgg cggcggggac      240

cccggggctc gcctccgccc agggcccccc tccacgccct cgggagcccc gggcccccgc      300

tgagcactcc tcccgcacgc ctgggtccct ccggccggcg cgcagcccgg ccccagcgct      360

gtgggtcccc gcggggcgat gggttgatgg gcgccggggg acgcaggatg cggggggcgc      420

ccgcgcgcct gctgctgccg ctgctgccgt ggctcctgct gctcctggcg cccgaggctc      480

ggggcgcgcc cggctgcccg ctatccatcc gcagctgcaa gtgctcgggg gagcggccca      540

aggggctgag cggcggcgtc cctggcccgg ctcggcggag ggtggtgtgc agcggcgggg      600

acctcccgga gcctcccgag cccggccttc tgcctaacgg caccgttacc ctgctcttga      660

gcaataacaa gatcacgggg ctccgcaatg gctccttcct gggactgtca ctgctggaga      720

agctggacct gaggaacaac atcatcagca cagtgcagcc gggcgccttc ctgggcctgg      780

gggagctgaa gcgtttagat ctctccaaca accggattgg ctgtctcacc tccgagacct      840

tccagggcct ccccaggctt ctccgactaa acatatctgg aaacatcttc tccagtctgc      900

aacctggggt ctttgatgag ctgccagccc ttaaggttgt ggacttgggc accgagttcc      960

tgacctgtga ctgccacctg cgctggctgc tgccctgggc ccagaatcgc tccctgcagc     1020

tgtcggaaca cacgctctgt gcttacccca gtgccctgca tgctcaggcc ctgggcagcc     1080

tccaggaggc ccagctctgc tgcgaggggg ccctggagct gcacacacac cacctcatcc     1140

cgtccctacg ccaagtggtg ttccaggggg atcggctgcc cttccagtgc tctgccagct     1200

acctgggcaa cgacacccgc atccgctggt accacaaccg agcccctgtg gagggtgatg     1260

agcaggcggg catcctcctg gccgagagcc tcatccacga ctgcaccttc atcaccagtg     1320

agctgacgct gtctcacatc ggcgtgtggg cctcaggcga gtgggagtgc accgtgtcca     1380

tggcccaagg caacgccagc aagaaggtgg agatcgtggt gctggagacc tctgcctcct     1440

actgccccgc cgagcgtgtt gccaacaacc gcggggactt caggtggccc cgaactctgg     1500

ctggcatcac agcctaccag tcctgcctgc agtatccctt cacctcagtg cccctgggcg     1560

ggggtgcccc gggcacccga gcctcccgcc ggtgtgaccg tgccggccgc tgggagccag     1620

gggactactc ccactgtctc tacaccaacg acatcaccag ggtgctgtac accttcgtgc     1680

tgatgcccat caatgcctcc aatgcgctga ccctggctca ccagctgcgc gtgtacacag     1740

ccgaggccgc tagcttttca gacatgatgg atgtagtcta tgtggctcag atgatccaga     1800

aatttttggg ttatgtcgac cagatcaaag agctggtaga ggtgatggtg gacatggcca     1860

gcaacctgat gctggtggac gagcacctgc tgtggctggc ccagcgcgag gacaaggcct     1920

gcagccgcat cgtgggtgcc ctggagcgca ttgggggggc cgccctcagc ccccatgccc     1980

agcacatctc agtgaatgcg aggaacgtgg cattggaggc ctacctcatc aagccgcaca     2040

gctacgtggg cctgacctgc acagccttcc agaggaggga gggaggggtg ccgggcacac     2100

ggccaggaag ccctggccag aaccccccac ctgagcccga gcccccagct gaccagcagc     2160

tccgcttccg ctgcaccacc gggaggccca atgtttctct gtcgtccttc cacatcaaga     2220

acagcgtggc cctggcctcc atccagctgc ccccgagtct attctcatcc cttccggctg     2280

ccctggctcc cccggtgccc ccagactgca ccctgcaact gctcgtcttc cgaaatggcc     2340

gcctcttcca cagccacagc aacacctccc gccctggagc tgctgggcct ggcaagaggc     2400

gtggcgtggc cacccccgtc atcttcgcag gaaccagtgg ctgtggcgtg ggaaacctga     2460

cagagccagt ggccgtttcg ctgcggcact gggctgaggg agccgaacct gtggccgctt     2520

ggtggagcca ggaggggccc ggggaggctg ggggctggac ctcggagggc tgccagctcc     2580

gctccagcca gcccaatgtc agcgccctgc actgccagca cttgggcaat gtggccgtgc     2640

tcatggagct gagcgccttt cccagggagg tggggggcgc cggggcaggg ctgcaccccg     2700

tggtataccc ctgcacggcc ttgctgctgc tctgcctctt cgccaccatc atcacctaca     2760

tcctcaacca cagctccatc cgtgtgtccc ggaaaggctg gcacatgctg ctgaacttgt     2820

gcttccacat agccatgacc tctgctgtct ttgcgggggg catcacactc accaactacc     2880

agatggtctg ccaggcggtg ggcatcaccc tgcactactc ctccctatcc acgctgctct     2940

ggatgggcgt gaaggcgcga gtgctccata aggagctcac ctggagggca ccccctccgc     3000

aagaagggga ccccgctctg cctactccca gtcctatgct ccggttctat ttgatcgctg     3060

gagggattcc actcattatc tgtggcatca cagctgcagt caacatccac aactaccggg     3120

accacagccc ctactgctgg ctggtgtggc gtccaagcct tggcgccttc tacatccctg     3180

tggctttgat tctgctcatc acctggatct atttcctgtg cgccgggcta cgcttacggg     3240

gtcctctggc acagaacccc aaggcgggca acagcagggc ctccctggag gcaggggagg     3300

agctgagggg ttccaccagg ctcaggggca gcggccccct cctgagtgac tcaggttccc     3360

ttcttgctac tgggagcgcg cgagtgggga cgcccgggcc cccggaggat ggtgacagcc     3420

tctattctcc gggagtccag ctaggggcgc tggtgaccac gcacttcctg tacttggcca     3480

tgtgggcctg cggggctctg gcagtgtccc agcgctggct gccccgggtg gtgtgcagct     3540

gcttgtacgg ggtggcagcc tccgccctgg gcctcttcgt cttcactcac cactgtgcca     3600

ggcggaggga cgtgagagcc tcgtggcgcg cctgctgccc ccctgcctct cccgcggccc     3660

cccatgcccc gccccgggcc ctgcccgccg ccgcagagga cggttccccg gtgttcgggg     3720

agggcccccc ctccctcaag tcctccccaa gcggcagcag cggccatccg ctggctctgg     3780

gcccctgcaa gctcaccaac ctgcagctgg cccagagtca ggtgtgcgag gcgggggcgg     3840

cggccggcgg ggaaggagag ccggagccgg cgggcacccg gggaaacctc gcccaccgcc     3900

accccaacaa cgtgcaccac gggcgtcggg cgcacaagag ccgggccaag ggacaccgcg     3960

cgggggaggc ctgcggcaag aaccggctca aggccctgcg cgggggcgcg gcgggggcgc     4020

tggagctgct gtccagcgag agcggcagtc tgcacaacag ccccaccgac agctacctgg     4080

gcagcagccg caacagcccg ggcgccggcc tgcagctgga aggcgagccc atgctcacgc     4140

cgtccgaggg cagcgacacc agcgccgcgc cgctttctga ggcgggccgg gcaggccagc     4200

gccgcagcgc cagccgcgac agtctcaagg gcggcggcgc gctggagaag gagagccatc     4260

gccgctcgta cccgctcaac gccgccagcc taaacggcgc ccccaagggg ggcaagtacg     4320

acgacgtcac cctgatgggc gcggaggtag ccagcggcgg ctgcatgaag accggactct     4380

ggaagagcga aactaccgtc taaggtgggg cgggcgacgc ggtagacggg ctggccacgc     4440

ggctcgttcc cccgctcctc ggggccctcc aaggtgtctc cgtagtcagc aggttggagg     4500

cagaggagcc gatggctgga ggaagcccac aggcggatgt tccccacttg cctagagggc     4560

atccctctgg ggtagcgaca gacaatccca gaaacacgca taatacattt ccgtccagcc     4620

cggggcagtc tgactgtcgg tgccctccca ggaacgggga aggcctccgt ctgtgtgaaa     4680

gggcacagca catcccaggt gcaccctccc caagtactcc caccccgcct actgtccatg     4740

cggcctcact gggggccatc agcctcacca gcaaagcaga gatgagagcg tgggaactgt     4800

gttctttcct ccctgccctc tactgatttc agcccagccc ctgcctagat cctaggtccc     4860

ttttcctccc gagtttggct ggcacgagag ctagcccagc acatgaagca ggtgatgtta     4920

agtcacaagg tgctgctttt cagatccact atgcaagagg ggagggtggg gccacgtgaa     4980

aggcagctct agacatcaac cagtcctggg ggaggggagt gggaaccggg cacaactagg     5040

aacaatgcca ccattcccac aggagtggta cttaaaccag acagcagggt tcagaggtgg     5100

cacaccggga caaagctgag gccctgcacc tcaacagctg actgccaggt gcctgtgggt     5160

gaactgaggg gagtagaggg agagggcagg tggaactggg gcagaatcta gtcatgccct     5220

aaagctagtc ctgtaaacaa tggtgcccca gaaagctgca ggtggtgttt ggagaagcag     5280

ttacttttca gttacaagac ccatctccct agtctcagcc ttacaacacc acgggactaa     5340

ggaagagcac ttccttgcct ccgtaaggcc agaggaagaa ccatcccaat catttgatct     5400

ccagctccac agtagagaga aacctacaaa atgtcaaacc agcttcccga ctcccaggag     5460

ctcaagccaa gcccagaggc agtggctggg gtccctgcag gtcatgaggg gcctatgcct     5520

ttactccttt taaacaccag cacccgtctt ttccccaacc taaaaccaac caccagcatt     5580

tcactacagg accaaatgga aaccgaggga accctgggtc ttgggaagaa caacaggaaa     5640

ccaaggtctg acctagggtt ccctcccagt cttcacatca ctctggcctc atcaccaagg     5700

tgacagagga cacaggggag ggggaaaacc cacacacact ccttggaatg ggtcctgtta     5760

tttatgcttg ctgcacagac atattagaag aaaaaaaaaa gctttgtatt attcttccac     5820

atatgctggc tgctgtttac acaccctgcc aatgccttag cactggagag ctttttgcaa     5880

tatgctgggg aaaggggagg gagggaatga aagtgccaaa gaaaacatgt ttttaagaac     5940

tcgggtttta tacaatagaa tgttttctag cagatgcctc ttgttttaat atattaaaat     6000

tttgcaaagc cctttgagct actgccttag tctaaaaaaa aaaaaaaaaa                6050


<210>  721
<211>  1338
<212>  PRT
<213>  Homo Sapiens

<400>  721

Met Gly Ala Gly Gly Arg Arg Met Arg Gly Ala Pro Ala Arg Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Leu Leu Leu Leu Leu Ala Pro Glu Ala Arg 
            20                  25                  30          


Gly Ala Pro Gly Cys Pro Leu Ser Ile Arg Ser Cys Lys Cys Ser Gly 
        35                  40                  45              


Glu Arg Pro Lys Gly Leu Ser Gly Gly Val Pro Gly Pro Ala Arg Arg 
    50                  55                  60                  


Arg Val Val Cys Ser Gly Gly Asp Leu Pro Glu Pro Pro Glu Pro Gly 
65                  70                  75                  80  


Leu Leu Pro Asn Gly Thr Val Thr Leu Leu Leu Ser Asn Asn Lys Ile 
                85                  90                  95      


Thr Gly Leu Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys 
            100                 105                 110         


Leu Asp Leu Arg Asn Asn Ile Ile Ser Thr Val Gln Pro Gly Ala Phe 
        115                 120                 125             


Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu Ser Asn Asn Arg Ile 
    130                 135                 140                 


Gly Cys Leu Thr Ser Glu Thr Phe Gln Gly Leu Pro Arg Leu Leu Arg 
145                 150                 155                 160 


Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu Gln Pro Gly Val Phe 
                165                 170                 175     


Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu Gly Thr Glu Phe Leu 
            180                 185                 190         


Thr Cys Asp Cys His Leu Arg Trp Leu Leu Pro Trp Ala Gln Asn Arg 
        195                 200                 205             


Ser Leu Gln Leu Ser Glu His Thr Leu Cys Ala Tyr Pro Ser Ala Leu 
    210                 215                 220                 


His Ala Gln Ala Leu Gly Ser Leu Gln Glu Ala Gln Leu Cys Cys Glu 
225                 230                 235                 240 


Gly Ala Leu Glu Leu His Thr His His Leu Ile Pro Ser Leu Arg Gln 
                245                 250                 255     


Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr 
            260                 265                 270         


Leu Gly Asn Asp Thr Arg Ile Arg Trp Tyr His Asn Arg Ala Pro Val 
        275                 280                 285             


Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala Glu Ser Leu Ile His 
    290                 295                 300                 


Asp Cys Thr Phe Ile Thr Ser Glu Leu Thr Leu Ser His Ile Gly Val 
305                 310                 315                 320 


Trp Ala Ser Gly Glu Trp Glu Cys Thr Val Ser Met Ala Gln Gly Asn 
                325                 330                 335     


Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu Thr Ser Ala Ser Tyr 
            340                 345                 350         


Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly Asp Phe Arg Trp Pro 
        355                 360                 365             


Arg Thr Leu Ala Gly Ile Thr Ala Tyr Gln Ser Cys Leu Gln Tyr Pro 
    370                 375                 380                 


Phe Thr Ser Val Pro Leu Gly Gly Gly Ala Pro Gly Thr Arg Ala Ser 
385                 390                 395                 400 


Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro Gly Asp Tyr Ser His 
                405                 410                 415     


Cys Leu Tyr Thr Asn Asp Ile Thr Arg Val Leu Tyr Thr Phe Val Leu 
            420                 425                 430         


Met Pro Ile Asn Ala Ser Asn Ala Leu Thr Leu Ala His Gln Leu Arg 
        435                 440                 445             


Val Tyr Thr Ala Glu Ala Ala Ser Phe Ser Asp Met Met Asp Val Val 
    450                 455                 460                 


Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly Tyr Val Asp Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Val Glu Val Met Val Asp Met Ala Ser Asn Leu Met Leu 
                485                 490                 495     


Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg Glu Asp Lys Ala Cys 
            500                 505                 510         


Ser Arg Ile Val Gly Ala Leu Glu Arg Ile Gly Gly Ala Ala Leu Ser 
        515                 520                 525             


Pro His Ala Gln His Ile Ser Val Asn Ala Arg Asn Val Ala Leu Glu 
    530                 535                 540                 


Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly Leu Thr Cys Thr Ala 
545                 550                 555                 560 


Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Thr Arg Pro Gly Ser Pro 
                565                 570                 575     


Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro Ala Asp Gln Gln Leu 
            580                 585                 590         


Arg Phe Arg Cys Thr Thr Gly Arg Pro Asn Val Ser Leu Ser Ser Phe 
        595                 600                 605             


His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile Gln Leu Pro Pro Ser 
    610                 615                 620                 


Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro Pro Val Pro Pro Asp 
625                 630                 635                 640 


Cys Thr Leu Gln Leu Leu Val Phe Arg Asn Gly Arg Leu Phe His Ser 
                645                 650                 655     


His Ser Asn Thr Ser Arg Pro Gly Ala Ala Gly Pro Gly Lys Arg Arg 
            660                 665                 670         


Gly Val Ala Thr Pro Val Ile Phe Ala Gly Thr Ser Gly Cys Gly Val 
        675                 680                 685             


Gly Asn Leu Thr Glu Pro Val Ala Val Ser Leu Arg His Trp Ala Glu 
    690                 695                 700                 


Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln Glu Gly Pro Gly Glu 
705                 710                 715                 720 


Ala Gly Gly Trp Thr Ser Glu Gly Cys Gln Leu Arg Ser Ser Gln Pro 
                725                 730                 735     


Asn Val Ser Ala Leu His Cys Gln His Leu Gly Asn Val Ala Val Leu 
            740                 745                 750         


Met Glu Leu Ser Ala Phe Pro Arg Glu Val Gly Gly Ala Gly Ala Gly 
        755                 760                 765             


Leu His Pro Val Val Tyr Pro Cys Thr Ala Leu Leu Leu Leu Cys Leu 
    770                 775                 780                 


Phe Ala Thr Ile Ile Thr Tyr Ile Leu Asn His Ser Ser Ile Arg Val 
785                 790                 795                 800 


Ser Arg Lys Gly Trp His Met Leu Leu Asn Leu Cys Phe His Ile Ala 
                805                 810                 815     


Met Thr Ser Ala Val Phe Ala Gly Gly Ile Thr Leu Thr Asn Tyr Gln 
            820                 825                 830         


Met Val Cys Gln Ala Val Gly Ile Thr Leu His Tyr Ser Ser Leu Ser 
        835                 840                 845             


Thr Leu Leu Trp Met Gly Val Lys Ala Arg Val Leu His Lys Glu Leu 
    850                 855                 860                 


Thr Trp Arg Ala Pro Pro Pro Gln Glu Gly Asp Pro Ala Leu Pro Thr 
865                 870                 875                 880 


Pro Ser Pro Met Leu Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu 
                885                 890                 895     


Ile Ile Cys Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp 
            900                 905                 910         


His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe 
        915                 920                 925             


Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu 
    930                 935                 940                 


Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala 
945                 950                 955                 960 


Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser 
                965                 970                 975     


Thr Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu 
            980                 985                 990         


Leu Ala Thr Gly Ser Ala Arg Val  Gly Thr Pro Gly Pro  Pro Glu Asp 
        995                 1000                 1005             


Gly Asp  Ser Leu Tyr Ser Pro  Gly Val Gln Leu Gly  Ala Leu Val 
    1010                 1015                 1020             


Thr Thr  His Phe Leu Tyr Leu  Ala Met Trp Ala Cys  Gly Ala Leu 
    1025                 1030                 1035             


Ala Val  Ser Gln Arg Trp Leu  Pro Arg Val Val Cys  Ser Cys Leu 
    1040                 1045                 1050             


Tyr Gly  Val Ala Ala Ser Ala  Leu Gly Leu Phe Val  Phe Thr His 
    1055                 1060                 1065             


His Cys  Ala Arg Arg Arg Asp  Val Arg Ala Ser Trp  Arg Ala Cys 
    1070                 1075                 1080             


Cys Pro  Pro Ala Ser Pro Ala  Ala Pro His Ala Pro  Pro Arg Ala 
    1085                 1090                 1095             


Leu Pro  Ala Ala Ala Glu Asp  Gly Ser Pro Val Phe  Gly Glu Gly 
    1100                 1105                 1110             


Pro Pro  Ser Leu Lys Ser Ser  Pro Ser Gly Ser Ser  Gly His Pro 
    1115                 1120                 1125             


Leu Ala  Leu Gly Pro Cys Lys  Leu Thr Asn Leu Gln  Leu Ala Gln 
    1130                 1135                 1140             


Ser Gln  Val Cys Glu Ala Gly  Ala Ala Ala Gly Gly  Glu Gly Glu 
    1145                 1150                 1155             


Pro Glu  Pro Ala Gly Thr Arg  Gly Asn Leu Ala His  Arg His Pro 
    1160                 1165                 1170             


Asn Asn  Val His His Gly Arg  Arg Ala His Lys Ser  Arg Ala Lys 
    1175                 1180                 1185             


Gly His  Arg Ala Gly Glu Ala  Cys Gly Lys Asn Arg  Leu Lys Ala 
    1190                 1195                 1200             


Leu Arg  Gly Gly Ala Ala Gly  Ala Leu Glu Leu Leu  Ser Ser Glu 
    1205                 1210                 1215             


Ser Gly  Ser Leu His Asn Ser  Pro Thr Asp Ser Tyr  Leu Gly Ser 
    1220                 1225                 1230             


Ser Arg  Asn Ser Pro Gly Ala  Gly Leu Gln Leu Glu  Gly Glu Pro 
    1235                 1240                 1245             


Met Leu  Thr Pro Ser Glu Gly  Ser Asp Thr Ser Ala  Ala Pro Leu 
    1250                 1255                 1260             


Ser Glu  Ala Gly Arg Ala Gly  Gln Arg Arg Ser Ala  Ser Arg Asp 
    1265                 1270                 1275             


Ser Leu  Lys Gly Gly Gly Ala  Leu Glu Lys Glu Ser  His Arg Arg 
    1280                 1285                 1290             


Ser Tyr  Pro Leu Asn Ala Ala  Ser Leu Asn Gly Ala  Pro Lys Gly 
    1295                 1300                 1305             


Gly Lys  Tyr Asp Asp Val Thr  Leu Met Gly Ala Glu  Val Ala Ser 
    1310                 1315                 1320             


Gly Gly  Cys Met Lys Thr Gly  Leu Trp Lys Ser Glu  Thr Thr Val 
    1325                 1330                 1335             


<210>  722
<211>  1405
<212>  DNA
<213>  Homo Sapiens

<400>  722
cggaggacca gggaccggct ccggaccgcg cagttagcgc cgcctggcct gggccggacc       60

cggtcagggt tctcaagctg tcgtccctat ggggctgtgt tttccttgtc ccggggagtc      120

cgcgcctccc acgccggacc tggaagagaa aagagcaaag cttgcagagg ctgcagagag      180

aagacaaaaa gaggctgcat ctcggggaat tttagatgtt caatctgtgc aagaaaagag      240

aaagaaaaag gaaaaaatag aaaaacaaat tgctacatcc gggcccccac cagaaggtgg      300

acttaggtgg acagtttcat aaagcataac atgagtagaa gaatctactg ccaataactg      360

tttattatct gcaatcaagt gggcttcatc aatttaattt cttctctttg agtaaatgaa      420

gattcagact ttgtaatatt attgccctta agtgcaatgc taaaaaaacg ttgattttca      480

agcttagaga atggctagac ttttcattaa atactgattt tcctacattt gctcttctgc      540

agttagtggg tgatttgcta tttttcttag tagttaaaaa atggaactaa atagtgaata      600

tacatacact gcatgtaaac attctgcata tacctctaag attaaaattc gcagttgtct      660

tttcatcctt tataaaatga tctaactact tatatttgtg ctgcatcgcg ttacatctgt      720

ttttatttca ctatgaagat gtttgattaa acttatggac ttagtgcctt taaactgatc      780

atcagggaga atcttgaaaa aatcatttga agggctgatg tgaaggagca ctgtaaattt      840

ttataactta gtaatgagta ttcttaggca gatgtaaaat tttttccaat ttatttttat      900

ttatgtagct tataaaatta acataccctg ttttacttta tgataaagga ttttttgttt      960

gctgaattta aaattatata ttagtgatac catcagaggg cagtgatgtt ctattgtata     1020

ttaaattcag ctctgtaagg atctttgtag taattgaatg agttaaacta ataatctgga     1080

tgggttataa tgagtagtaa tatatttgtc catatttcat aagtagtgtt aatcttgtgt     1140

acttattaga gaacgatcat aagatttata cagatgtgaa actgcgaagg caagtatgaa     1200

tgtatgaaaa aaacatgtag gtactgtact tacaaaaggt ctacttcaga tataaaaata     1260

ttaggtaatt ctatacaatg catagtcata aaccttaaca tttttgttca ttagaaacat     1320

gaattttata gcattttttg tttctcctat ataatacact gaaataaaag aatttgtgtt     1380

agctattaaa aaaaaaaaaa aaaaa                                           1405


<210>  723
<211>  77
<212>  PRT
<213>  Homo Sapiens

<400>  723

Met Gly Leu Cys Phe Pro Cys Pro Gly Glu Ser Ala Pro Pro Thr Pro 
1               5                   10                  15      


Asp Leu Glu Glu Lys Arg Ala Lys Leu Ala Glu Ala Ala Glu Arg Arg 
            20                  25                  30          


Gln Lys Glu Ala Ala Ser Arg Gly Ile Leu Asp Val Gln Ser Val Gln 
        35                  40                  45              


Glu Lys Arg Lys Lys Lys Glu Lys Ile Glu Lys Gln Ile Ala Thr Ser 
    50                  55                  60                  


Gly Pro Pro Pro Glu Gly Gly Leu Arg Trp Thr Val Ser 
65                  70                  75          


<210>  724
<211>  4318
<212>  DNA
<213>  Homo Sapiens

<400>  724
agcagcgctc atggcgaaga ggcttaaggc cacaaaaccg tgggacagca ggaggaagag       60

aagccaggta tctccactcc agctgccctg cctcagactc ctcagtttcg cacgtgagga      120

tcgtcttgca ggcactgact ggagatggaa tcctaaagca taggtgaagc ggaaatcctc      180

cttcagggag agcccactga ggaagccagc ggctagcacg aggcaggaca ggatacctcc      240

ctcttcgccc acggcggcct ctctgtcata gtagccaccg ttctgccact catgcagctt      300

tctaagacac ctctcggttc cccagcgctt tcagtggggc ggccggccat tcccgagggt      360

tgcaagagga ggcccggggt gctgagccag cctcgctgcc cccgcgtaga aagccggccc      420

gccggcgaga gccagcctaa ggcgcggaca accaacgagg tgtcaggctc ggcaggggat      480

tgcttctgtc tggggcccgg ccgaggttgc gttcgtgcct cgcgcgcaca cgctccgcgt      540

tcactcagcc aatccggtgc tactcgcgcg cccaggagcg atccgcggtc ctactcaggc      600

tgggccggct ccttcccgct cccaatactc agcacccgag ctctcactcc tcccctcact      660

ctccacgagt tccacgccta ggggtgtagc tccgcccttg tccccgagtc cgcccccgca      720

acctccagag cgtgtgctat cctttcctct cagtcctgcc atctagctgc cttgggtctc      780

gcgctccgca gagcgttccg acactctccg gcctcgttct gccgcctccg cgcgctctcc      840

ccgtgcggcc accgcgcccc ccaagcttgc ctccttcttg ccggacttgg ggccgcgcgc      900

cctgactcct tcccctcccg cggacccgcg cactcccggc gcggcctctc ccccacgcag      960

gccaccgtgc actctgtggc ctccccctcc ttccccgctc tcctcgcgct tctctggctc     1020

cctagctgtc gcgctctcct cggcgagcgc gctcccggcc cgcgcgctcc gggctccggt     1080

ttctcccggc tcctgtcagt gcggtgactg cgctgggaaa catggcgacc gagggaatga     1140

tccttactaa ccacgaccat caaatccgtg tcggagtcct tacagtgagt gatagttgct     1200

tcaggaatct tgcagaagac cgcagtggga taaatctcaa agatctcgta caagatcctt     1260

ctttgttggg tgggactata tcagcataca agatagtacc agatgaaata gaagaaatca     1320

aggaaaccct gatagattgg tgtgatgaaa aggaacttaa tttgatatta acaactggag     1380

gaacaggatt tgcaccacga gatgtcactc cagaggccac aaaagaagta atagaacggg     1440

aagcaccagg gatggccctg gcaatgctga tgggatcact taatgttaca cctctgggca     1500

tgctctctag gcctgtatgt ggaatcagag ggaaaacgct cataattaac ctgccaggta     1560

gcaagaaagg atctcaggaa tgctttcaat tcatactgcc agctctacct catgccattg     1620

accttttacg tgatgccatt gtaaaagtaa aggaggtgca tgatgaactt gaagatttgc     1680

cttccccacc tccccctctt tcccctcctc ctactaccag cccccataaa cagacagaag     1740

acaaaggagt tcaatgtgag gaagaggaag aagagaagaa agacagtggt gttgcttcaa     1800

cagaagatag ttcctcatca catataactg cagcagccat tgctgccaag aagcatccat     1860

tctacaccag tcctgctgtt gtcatggcac acggtgaaca gcccatccct ggtctcatca     1920

attattccca tcattcaaca gatgaacgga ttccagactc catcatttct cgtggtgttc     1980

aggtgctccc acgagacaca gcctccctca gcactactcc ttcagaatcg cctcgtgctc     2040

aggctacatc tcgcctctct acagcttcct gcccaacacc aaaagtccag tccaggtgca     2100

gcagcaagga gaacattctc agagccagtc acagtgctgt cgatatcacc aaggtggcta     2160

gaagacatcg catgtctcct tttcctctga catctatgga caaagccttt atcacagtcc     2220

tggagatgac tccggtgctt gggacagaaa tcatcaatta ccgagatgga atggggcgag     2280

tccttgctca agatgtatat gcaaaagaca atttaccccc cttcccagca tcagtaaaag     2340

atggctatgc tgtccgagct gctgatggcc caggagatcg tttcatcatt ggggaatccc     2400

aagctggtga acagccaact cagacagtaa tgccaggaca agtcatgcgg gttacaacag     2460

gtgctccaat accctgcggt gctgatgcag tagtacaagt ggaagatacc gaacttatca     2520

gggaatcaga tgatggcact gaagaacttg aagtgcgaat tctggtgcaa gctcggccag     2580

gccaagatat cagacccatc ggccatgaca ttaaaagagg ggaatgtgtt ttggccaaag     2640

gaacccacat gggcccctca gagattggtc ttctggcaac tgtaggtgtc acagaggttg     2700

aagttaataa gtttccagtg gttgcagtca tgtcaacagg gaatgagctg ctaaatcctg     2760

aagatgacct cttaccaggg aagattcgag acagcaatcg ttcaactctt ctagcaacaa     2820

ttcaggaaca tggttacccc acgatcaact tgggtattgt aggagacaac ccagatgact     2880

tactcaatgc cttgaatgag ggtatcagtc gtgctgatgt catcatcaca tcagggggtg     2940

tatccatggg ggaaaaggac tatctcaagc aggtgctgga cattgatctt catgctcaga     3000

tccattttgg cagggttttt atgaaaccag gcttgccaac aacatttgca actttggata     3060

ttgatggtgt aagaaaaata atctttgcac tacctgggaa tcctgtatcg gctgtggtca     3120

cctgcaatct ctttgttgtg cctgcactga ggaaaatgca gggcatcttg gatcctcggc     3180

caaccatcat caaagcaagg ttatcatgtg atgtaaaact tgatcctcgt ccagaatacc     3240

atcggtgtat actaacttgg catcaccaag aaccactacc ttgggcacag agtacaggta     3300

atcaaatgag cagccgtctg atgagcatgc gcagtgccaa tggattgttg atgctacctc     3360

caaagacaga acagtacgtg gagctccaca aaggcgaggt ggtggatgtc atggtcattg     3420

gacggctatg atggtcacca gcaggagaaa gctttgatgc atgtccacat atcattgact     3480

gtatcctgta atatgcaacg gcacagctag ttttcccgat ttggataaaa gttgatctgt     3540

atagtcaaca tcttgaacta tatttcaaat gaatttaaat atcttttaaa gaaaaaaaca     3600

cctaaaaata aatcttaaca gaaaattctg ttctgattat atcaaggcaa atttttcctt     3660

tcttgcaaat tgctttgtgt gttcaatgct aggtctgata gcgatagctt ttagtagaca     3720

gcggtaggtg cctgcagaac ttgtgttttt ctcatcttta aaatacaact acttatgctc     3780

ttaaatcaag gctgtctgct tatttatact agcgtaggca acacttggat ttcccttctt     3840

agtatgcttc ataactgctt tacagagagc ttttgcttgt tctttctcat gtatctcgtg     3900

tttatgtgca cagtgccaaa agaagactga ctgggtggag gctctgcctt gcctcaagaa     3960

ccatcccctg cagagcatcc agggaggttt ctcgccccaa tagcctcacg gcacagtact     4020

cttgggcagt aactggacac cttttatttg aagaaacaaa ctgaagaaaa aatgcttcct     4080

taagtgctga cagccttttt aaccaataca tttaaaattg tacagaacaa aaaaataaaa     4140

tcaaagactg atcttgtaca gatattagtg ttaccagcat tcatgtggaa atcaagagca     4200

aagacaaaat aatgttaaac aattctgtac cataacattt tctgtaatga tactgaaact     4260

taatgaataa aaaaattcct tgatcattat ttaaaaatgt aaaaaaaaaa aaaaaaaa       4318


<210>  725
<211>  769
<212>  PRT
<213>  Homo Sapiens

<400>  725

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
1               5                   10                  15      


Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
            20                  25                  30          


Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
        35                  40                  45              


Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
    50                  55                  60                  


Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
65                  70                  75                  80  


Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                85                  90                  95      


Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
            100                 105                 110         


Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
        115                 120                 125             


Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
    130                 135                 140                 


Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
145                 150                 155                 160 


Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                165                 170                 175     


Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
            180                 185                 190         


Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
        195                 200                 205             


Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
    210                 215                 220                 


Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Ala Lys Lys His Pro Phe Tyr Thr Ser Pro Ala Val Val Met Ala 
                245                 250                 255     


His Gly Glu Gln Pro Ile Pro Gly Leu Ile Asn Tyr Ser His His Ser 
            260                 265                 270         


Thr Asp Glu Arg Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val 
        275                 280                 285             


Leu Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro 
    290                 295                 300                 


Arg Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro 
305                 310                 315                 320 


Lys Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser 
                325                 330                 335     


His Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser 
            340                 345                 350         


Pro Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu 
        355                 360                 365             


Met Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met 
    370                 375                 380                 


Gly Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro 
385                 390                 395                 400 


Phe Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly 
                405                 410                 415     


Pro Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro 
            420                 425                 430         


Thr Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala 
        435                 440                 445             


Pro Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu 
    450                 455                 460                 


Leu Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile 
465                 470                 475                 480 


Leu Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp 
                485                 490                 495     


Ile Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro 
            500                 505                 510         


Ser Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val 
        515                 520                 525             


Asn Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu 
    530                 535                 540                 


Asn Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg 
545                 550                 555                 560 


Ser Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn 
                565                 570                 575     


Leu Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn 
            580                 585                 590         


Glu Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser 
        595                 600                 605             


Met Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His 
    610                 615                 620                 


Ala Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr 
625                 630                 635                 640 


Thr Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala 
                645                 650                 655     


Leu Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val 
            660                 665                 670         


Val Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr 
        675                 680                 685             


Ile Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro 
    690                 695                 700                 


Glu Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro 
705                 710                 715                 720 


Trp Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met 
                725                 730                 735     


Arg Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr 
            740                 745                 750         


Val Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg 
        755                 760                 765             


Leu 
    


<210>  726
<211>  3080
<212>  DNA
<213>  Homo Sapiens

<400>  726
gggtgcctca tattgccaga caagagctca gacctgagga gagtgactag cttctctgtg       60

tcccaggtgg ccaccttcca ctgtggaagc tcatggactc cattgggtct tcagggttgc      120

ggcaggggga agaaaccctg agttgctctg aggagggctt gcccgggccc tcagacagct      180

cagagctggt gcaggagtgc ctgcagcagt tcaaggtgac aagggcacag ctacagcaga      240

tccaagccag cctcttgggt tccatggagc aggcgctgag gggacaggcc agccctgccc      300

ctgcggtccg gatgctgcct acatacgtgg ggtccacccc acatggcact gagcaaggag      360

acttcgtggt gctggagctg ggggccacag gggcctcact gcgtgttttg tgggtgactc      420

taactggcat tgaggggcat agggtggagc ccagaagcca ggagtttgtg atcccccaag      480

aggtgatgct gggtgctggc cagcagctct ttgactttgc tgcccactgc ctgtctgagt      540

tcctggatgc gcagcctgtg aacaaacagg gtctgcagct tggcttcagc ttctctttcc      600

cttgtcacca gacgggcttg gacaggagca ccctcatttc ctggaccaaa ggttttaggt      660

gcagtggtgt ggaaggccag gatgtggtcc agctgctgag agatgccatt cggaggcagg      720

gggcctacaa catcgacgtg gttgctgtgg tgaacgacac agtgggcacc atgatgggct      780

gtgagccggg ggtcaggccg tgtgaggttg ggctagttgt agacacgggc accaacgcgt      840

gttacatgga ggaggcacgg catgtggcag tgctggacga agaccggggc cgcgtctgcg      900

tcagcgtcga gtggggctcc ttcagcgatg atggggcgct gggaccagtg ctgaccacct      960

tcgaccatac cctggaccat gagtccctga atcctggtgc tcagaggttt gagaagatga     1020

tcggaggcct gtacctgggt gagctggtgc ggctggtgct ggctcacttg gcccggtgtg     1080

gggtcctctt tggtggctgc acctcccctg ccctgctgag ccaaggcagc atcctcctgg     1140

aacacgtggc tgagatggag gacccctcta ctggggcagc ccgtgtccat gctatcctgc     1200

aggacttggg cctgagccct ggggcttcgg atgttgagct tgtgcagcac gtctgtgcgg     1260

ccgtgtgcac gcgggctgcc cagctctgtg ctgccgccct ggccgctgtt ctctcctgcc     1320

tccagcacag ccgggagcaa caaacactcc aggttgctgt ggccaccgga ggccgagtgt     1380

gtgagcggca ccccaggttc tgcagcgtcc tgcaggggac agtgatgctc ctggccccgg     1440

aatgcgatgt ctccttaatc ccctctgtgg atggtggtgg ccggggagtg gcgatggtga     1500

ctgccgtggc tgcccgtctg gctgcccacc ggcgcctgct ggaggagacc ctggccccat     1560

tccggttgaa ccatgatcaa ctggctgcgg ttcaggcaca gatgcggaag gccatggcca     1620

aggggctccg aggggaggcc tcctcccttc gcatgctgcc cactttcgtc cgggccaccc     1680

ctgacggcag cgagcgaggg gatttcctgg ccctggacct cgggggcacg aacttccgtg     1740

tcctcctggt acgtgtgacc acaggcgtgc agatcaccag cgagatctac tccattcccg     1800

agactgtggc ccagggttct gggcagcagc tctttgacca catcgtggac tgcatcgtgg     1860

acttccagca gaagcagggc ctgagcgggc agagcctccc actgggtttt accttctcct     1920

tcccatgtag gcagcttggc ctagaccagg gcatcctcct gaactggacc aagggtttca     1980

aggcatcaga ctgcgagggc caagatgtcg tgagtctgtt gcgggaagcc atcactcgca     2040

gacaggcagt ggagctgaat gtggttgcca ttgtcaatga cacggtgggg accatgatgt     2100

cctgtggcta tgaggacccc cgttgcgaga taggcctcat tgtcggaacc ggcaccaatg     2160

cctgctacat ggaggagctc cggaatgtgg cgggcgtgcc tggggactca ggccgcatgt     2220

gcatcaacat ggagtggggc gcctttgggg acgatggctc tctggccatg ctcagcaccc     2280

gctttgatgc aagtgtggac caggcgtcca tcaaccccgg caagcagagg tttgaaaaga     2340

tgatcagcgg catgtacctg ggggagatcg tccgccacat ccttttacat ttaaccagcc     2400

ttggcgttct cttccggggc cagcagatcc agcgccttca gaccagggac atcttcaaga     2460

ccaagttcct ctctgagatc gaaagtgaca gcctggccct gcggcaggtc cgagccatcc     2520

tagaggatct ggggctaccc ctgacctcag atgacgccct gatggtgcta gaggtgtgcc     2580

aggctgtgtc ccagagggct gcccagctct gtggggcggg tgtagctgcc gtggtggaga     2640

agatccggga gaaccggggc ctggaagagc tggcagtgtc tgtgggggtg gatggaacgc     2700

tctacaagct gcacccgcgc ttctccagcc tggtggcggc cacagtgcgg gagctggccc     2760

ctcgctgtgt ggtcacgttc ctgcagtcag aggatgggtc cggcaaaggt gcggccctgg     2820

tcaccgctgt tgcctgccgc cttgcgcagt tgactcgtgt ctgaggaaac ctccaggctg     2880

aggaggtctc cgccgcagcc ttgctggagc cgggtcgggg tctgcctgtt tcccagccag     2940

gcccagccac ccaggactcc tgggacatcc catgtgtgac ccctctgcgg ccatttggcc     3000

ttgctccctg gctttccctg agagaagtag cactcaggtt agcaatatat atatataatt     3060

tatttacaaa aaaaaaaaaa                                                 3080


<210>  727
<211>  923
<212>  PRT
<213>  Homo Sapiens

<400>  727

Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu 
1               5                   10                  15      


Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu 
            20                  25                  30          


Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln 
        35                  40                  45              


Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly 
    50                  55                  60                  


Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly 
65                  70                  75                  80  


Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu 
                85                  90                  95      


Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly 
            100                 105                 110         


Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro 
        115                 120                 125             


Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala 
    130                 135                 140                 


His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly 
145                 150                 155                 160 


Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu 
                165                 170                 175     


Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly 
            180                 185                 190         


Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg 
        195                 200                 205             


Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val 
    210                 215                 220                 


Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly 
225                 230                 235                 240 


Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg 
                245                 250                 255     


His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val 
            260                 265                 270         


Glu Trp Gly Ser Phe Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr 
        275                 280                 285             


Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln 
    290                 295                 300                 


Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg 
305                 310                 315                 320 


Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys 
                325                 330                 335     


Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val 
            340                 345                 350         


Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile 
        355                 360                 365             


Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val 
    370                 375                 380                 


Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala 
385                 390                 395                 400 


Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln 
                405                 410                 415     


Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg 
            420                 425                 430         


His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala 
        435                 440                 445             


Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg 
    450                 455                 460                 


Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln 
                485                 490                 495     


Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu 
            500                 505                 510         


Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala 
        515                 520                 525             


Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly 
    530                 535                 540                 


Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln 
545                 550                 555                 560 


Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser 
                565                 570                 575     


Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln 
            580                 585                 590         


Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val 
625                 630                 635                 640 


Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn 
                645                 650                 655     


Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly 
            660                 665                 670         


Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly 
    690                 695                 700                 


Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp 
                725                 730                 735     


Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr 
        755                 760                 765             


Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr 
    770                 775                 780                 


Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser 
785                 790                 795                 800 


Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro 
                805                 810                 815     


Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val 
            820                 825                 830         


Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val 
        835                 840                 845             


Glu Lys Ile Arg Glu Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu 
865                 870                 875                 880 


Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe 
                885                 890                 895     


Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala 
            900                 905                 910         


Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val 
        915                 920             


<210>  728
<211>  921
<212>  DNA
<213>  Homo Sapiens

<400>  728
aatgatgaaa gagtgcaagc tctcacttcc ccttcctgta cagggcaggt tgtgcagctg       60

gaggcagagc agtcctctct ggggagcctg aagcaaacat ggatcaagaa actgtaggca      120

atgttgtcct gttggccatc gtcaccctca tcagcgtggt ccagaatgga ttctttgccc      180

ataaagtgga gcacgaaagc aggacccaga atgggaggag cttccagagg accggaacac      240

ttgcctttga gcgggtctac actgccaacc agaactgtgt agatgcgtac cccactttcc      300

tcgctgtgct ctggtctgcg gggctacttt gcagccaagt tcctgctgcg tttgctggac      360

tgatgtactt gtttgtgagg caaaagtact ttgtcggtta cctaggagag agaacgcaga      420

gcacccctgg ctacatattt gggaaacgca tcatactctt cctgttcctc atgtccgttg      480

ctggcatatt caactattac ctcatcttct ttttcggaag tgactttgaa aactacataa      540

agacgatctc caccaccatc tcccctctac ttctcattcc ctaactctct gctgaatatg      600

gggttggtgt tctcatctaa tcaataccta caagtcatca taattcagct cttgagagca      660

ttctgctctt ctttagatgg ctgtaaatct attggccatc tgggcttcac agcttgagtt      720

aaccttgctt ttccgggaac aaaatgatgt catgtcagct ccgccccttg aacatgaccg      780

tggccccaaa tttgctattc ccatgcattt tgtttgtttc ttcacttatc ctgttctctg      840

aagatgtttt gtgaccaggt ttgtgttttc ttaaaataaa atgcagagac atgttttaag      900

ctgataaaaa aaaaaaaaaa a                                                921


<210>  729
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  729

Met Asp Gln Glu Thr Val Gly Asn Val Val Leu Leu Ala Ile Val Thr 
1               5                   10                  15      


Leu Ile Ser Val Val Gln Asn Gly Phe Phe Ala His Lys Val Glu His 
            20                  25                  30          


Glu Ser Arg Thr Gln Asn Gly Arg Ser Phe Gln Arg Thr Gly Thr Leu 
        35                  40                  45              


Ala Phe Glu Arg Val Tyr Thr Ala Asn Gln Asn Cys Val Asp Ala Tyr 
    50                  55                  60                  


Pro Thr Phe Leu Ala Val Leu Trp Ser Ala Gly Leu Leu Cys Ser Gln 
65                  70                  75                  80  


Val Pro Ala Ala Phe Ala Gly Leu Met Tyr Leu Phe Val Arg Gln Lys 
                85                  90                  95      


Tyr Phe Val Gly Tyr Leu Gly Glu Arg Thr Gln Ser Thr Pro Gly Tyr 
            100                 105                 110         


Ile Phe Gly Lys Arg Ile Ile Leu Phe Leu Phe Leu Met Ser Val Ala 
        115                 120                 125             


Gly Ile Phe Asn Tyr Tyr Leu Ile Phe Phe Phe Gly Ser Asp Phe Glu 
    130                 135                 140                 


Asn Tyr Ile Lys Thr Ile Ser Thr Thr Ile Ser Pro Leu Leu Leu Ile 
145                 150                 155                 160 


Pro 
    


<210>  730
<211>  1409
<212>  DNA
<213>  Homo Sapiens

<400>  730
cgacttcctc tttccagtgc atttaaggcg cagcctggaa gtgccaggga gcactggagg       60

ccacccagtc atgggggaca ccttcatccg tcacatcgcc ctgctgggct ttgagaagcg      120

cttcgtaccc agccagcact atgtgtacat gttcctggtg aaatggcagg acctgtcgga      180

gaaggtggtc taccggcgct tcaccgagat ctacgagttc cataaaacct taaaagaaat      240

gttccctatt gaggcagggg cgatcaatcc agagaacagg atcatccccc acctcccagc      300

tcccaagtgg tttgacgggc agcgggccgc cgagaaccgc cagggcacac ttaccgagta      360

ctgcggcacg ctcatgagcc tgcccaccaa gatctcccgc tgtccccacc tcctcgactt      420

cttcaaggtg cgccctgatg acctcaagct ccccacggac aaccagacaa aaaagccaga      480

gacatacttg atgcccaaag atggcaagag taccgcgaca gacatcaccg gccccatcat      540

cctgcagacg taccgcgcca ttgccaacta cgagaagacc tcgggctccg agatggctct      600

gtccacgggg gacgtggtgg aggtcgtaga gaagagcgag agcggttggt ggttctgtca      660

gatgaaagca aagcgaggct ggatcccagc gtccttcctc gagcccctgg acagtcctga      720

cgagacggaa gaccctgagc ccaactatgc aggtgagcca tacgtcgcca tcaaggccta      780

cactgctgtg gagggggacg aggtgtccct gctcgagggt gaagctgttg aggtcattca      840

caagctcctg gacggctggt gggtcatcag gaaagacgac gtcacaggct acttcccgtc      900

catgtacctg caaaagtcag ggcaagacgt gtcccaggcc caacgccaga tcaagcgggg      960

ggcgccgccc cgcaggtcgt ccatccgcaa cgcgcacagc atccaccagc ggtcgcggaa     1020

gcgcctcagc caggacgcct atcgccgcaa cagcgtccgt tttctgcagc agcgacgccg     1080

ccaggcgcgg ccgggaccgc agagccccgg gagcccgctc gaggaggagc ggcagacgca     1140

gcgctctaaa ccgcagccgg cggtgccccc gcggccgagc gccgacctca tcctgaaccg     1200

ctgcagcgag agcaccaagc ggaagctggc gtctgccgtc tgaggctgga gcgcagtccc     1260

cagctagcgt ctcggccctt gccgccccgt gcctgtacat acgtgttcta tagagcctgg     1320

cgtctggacg ccgagggcag ccccgacccc tgtccagcgc ggctcccgcc accctcaata     1380

aatgttgctt ggagtggaaa aaaaaaaaa                                       1409


<210>  731
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  731

Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly Phe Glu Lys 
1               5                   10                  15      


Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu Val Lys Trp 
            20                  25                  30          


Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr Glu Ile Tyr 
        35                  40                  45              


Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu Ala Gly Ala 
    50                  55                  60                  


Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala Pro Lys Trp 
65                  70                  75                  80  


Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr Leu Thr Glu 
                85                  90                  95      


Tyr Cys Gly Thr Leu Met Ser Leu Pro Thr Lys Ile Ser Arg Cys Pro 
            100                 105                 110         


His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu Lys Leu Pro 
        115                 120                 125             


Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met Pro Lys Asp 
    130                 135                 140                 


Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile Leu Gln Thr 
145                 150                 155                 160 


Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser Glu Met Ala 
                165                 170                 175     


Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser Glu Ser Gly 
            180                 185                 190         


Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile Pro Ala Ser 
        195                 200                 205             


Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp Pro Glu Pro 
    210                 215                 220                 


Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr Thr Ala Val 
225                 230                 235                 240 


Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val Glu Val Ile 
                245                 250                 255     


His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp Asp Val Thr 
            260                 265                 270         


Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln Asp Val Ser 
        275                 280                 285             


Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg Arg Ser Ser 
    290                 295                 300                 


Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys Arg Leu Ser 
305                 310                 315                 320 


Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln Gln Arg Arg 
                325                 330                 335     


Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro Leu Glu Glu 
            340                 345                 350         


Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val Pro Pro Arg 
        355                 360                 365             


Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser Thr Lys Arg 
    370                 375                 380                 


Lys Leu Ala Ser Ala Val 
385                 390 


<210>  732
<211>  933
<212>  DNA
<213>  Homo Sapiens

<400>  732
ggctgtgcgc tctggggcac ctcatgcaga cgggagtagg gaggctgttt tttgcgcgtg       60

catatggcgg tggcgggtgg ggggaagggg gagatcctgc tgcactggcc gcccaagttg      120

gggggcgagc tcggtggtga cgcgcggccc tcacgtgacc cagagctgca gagcgacgca      180

gccttcggtg cagtcgtcac tcgcgtctgg ctaccagctc cccgctgccc tgagctcggc      240

gggctggcat tcggcccggg gaaaagcgga gcaggtctgc gaggctaagt gtctccgcgg      300

cgcacctcgc ggcgagaatc cggaggagaa ggagactgca aggataggcc caggaaaacg      360

aagagatgga gcagcctatg cagaatggag aggaagaccg ccctttggga ggaggtgaag      420

gccaccagcc tgcaggaaat cgacggggac aggctcgccg acttgcccct aattttcgat      480

gggccatacc caataggcag atcaatgatg ggatgggtgg agatggagat gatatggaaa      540

tattcatgga ggagatgaga gaaatcagaa gaaaacttag ggagctgcag ttgaggaatt      600

gtctgcgtat ccttatgggg gagctctcta atcaccatga ccatcatgat gaattttgcc      660

ttatgccttg actcctgcca tttatcatga gattaatact gtgattcccg ctgttttctt      720

tttccttgca ttttcctaat atgcctttac tgatccgttt gctgtgaacc ctatgttatt      780

tccatgtgtc aagtgggtct tgtgttgcca gcttctattt gaagattgcc tttgcactca      840

gtgtaagttt ctgtcagcag tagtttcacc catttgcatg gaaaaattta aagctaataa      900

agcaatttaa aaagcaaaaa aaaaaaaaaa aaa                                   933


<210>  733
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  733

Met Glu Gln Pro Met Gln Asn Gly Glu Glu Asp Arg Pro Leu Gly Gly 
1               5                   10                  15      


Gly Glu Gly His Gln Pro Ala Gly Asn Arg Arg Gly Gln Ala Arg Arg 
            20                  25                  30          


Leu Ala Pro Asn Phe Arg Trp Ala Ile Pro Asn Arg Gln Ile Asn Asp 
        35                  40                  45              


Gly Met Gly Gly Asp Gly Asp Asp Met Glu Ile Phe Met Glu Glu Met 
    50                  55                  60                  


Arg Glu Ile Arg Arg Lys Leu Arg Glu Leu Gln Leu Arg Asn Cys Leu 
65                  70                  75                  80  


Arg Ile Leu Met Gly Glu Leu Ser Asn His His Asp His His Asp Glu 
                85                  90                  95      


Phe Cys Leu Met Pro 
            100     


<210>  734
<211>  5248
<212>  DNA
<213>  Homo Sapiens

<400>  734
gcgtgcaacc ctagaaggga aaaggacggg aagagattga gccgcggctg ggagacagcg       60

agccagagtc tgggtgtttg tgcgagagcc acggcggggg ctggggcgag tggccggcat      120

ggctgaaggc tgcgctctgc aaccttgaag agccgctgca ttgagaggcc agggacaggg      180

agaccggtgc gatggcagag cgcggccccc gccgctgcgc cgggccggcc cggctggcct      240

gagccgccgg aggagcgggg ctgcctctgc gcgtccatgg agcagcggga agggcgaaac      300

tccggagcgc cgcgtccctg cgccgctgcg gcggactgct gaaggggccg agcccgcgcg      360

gaccgccgag gaagagaccc ccgctccagc ccgcaggccg gctgcccggg ggcggcgggg      420

gacatcggag ggcagcggag cgagcagcgc cgcgggagag gccggcgcgg gaggcggccg      480

cagcaatgcc gggcccgcta gggctgctct gcttcctcgc cctggggctg ctcggctcgg      540

ccgggcccag cggcgcggcg ccgcctctct gcgcggcgcc ctgcagctgc gacggcgacc      600

gtcgggtgga ctgctccggg aaggggctga cggccgtgcc cgaggggctc agcgccttca      660

cccaagcgct ggatatcagt atgaacaaca ttactcagtt gccagaagat gcatttaaga      720

actttccttt tctagaagag ctacaattgg cgggcaacga cctttctttt atccacccaa      780

aggccttgtc tgggttgaaa gaactcaaag ttctaacgct ccagaataat cagttgaaaa      840

cagtacccag tgaagccatt cgagggctga gtgctttgca gtctttgcgt ttagatgcca      900

accatattac ctcagtcccc gaggacagtt ttgaaggact tgttcagtta cggcatctgt      960

ggctggatga caacagcttg acggaggtgc ctgtgcaccc cctcagcaat ctgcccaccc     1020

tacaggcgct gaccctggct ctcaacaaga tctcaagcat ccctgacttt gcatttacca     1080

acctttcaag cctggtagtt ctgcatcttc ataacaataa aattagaagc ctgagtcaac     1140

actgttttga tggactagat aacctggaga ccttagactt gaattataat aacttggggg     1200

aatttcctca ggctattaaa gcccttccta gccttaaaga gctaggattt catagtaatt     1260

ctatttctgt tatccctgat ggagcatttg atggtaatcc actcttaaga actatacatt     1320

tgtatgataa tcctctgtct tttgtgggga actcagcatt tcacaattta tctgatcttc     1380

attccctagt cattcgtggt gcaagcatgg tgcagcagtt ccccaatctt acaggaactg     1440

tccacctgga aagtctgact ttgacaggta caaagataag cagcatacct aataatttgt     1500

gtcaagaaca aaagatgctt aggactttgg acttgtctta caataatata agagaccttc     1560

caagttttaa tggttgccat gctctggaag aaatttcttt acagcgtaat caaatctacc     1620

aaataaagga aggcaccttt caaggcctga tatctctaag gattctagat ctgagtagaa     1680

acctgataca tgaaattcac agtagagctt ttgccacact tgggccaata actaacctag     1740

atgtaagttt caatgaatta acttcctttc ctacggaagg cctgaatggg ctaaatcaac     1800

tgaaacttgt gggcaacttc aagctgaaag aagccttagc agcaaaagac tttgttaacc     1860

tcaggtcttt atcagtacca tatgcttatc agtgctgtgc attttggggt tgtgactctt     1920

atgcaaattt aaacacagaa gataacagcc tccaggacca cagtgtggca caggagaaag     1980

gtactgctga tgcagcaaat gtcacaagca ctcttgaaaa tgaagaacat agtcaaataa     2040

ttatccattg tacaccttca acaggtgctt ttaagccctg tgaatattta ctgggaagct     2100

ggatgattcg tcttactgtg tggttcattt tcttggttgc attatttttc aacctgcttg     2160

ttattttaac aacatttgca tcttgtacat cactgccttc gtccaaattg tttataggct     2220

tgatttctgt gtctaactta ttcatgggaa tctatactgg catcctaact tttcttgatg     2280

ctgtgtcctg gggcagattc gctgaatttg gcatttggtg ggaaactggc agtggctgca     2340

aagtagctgg gtttcttgca gttttctcct cagaaagtgc catattttta ttaatgctag     2400

caactgtcga aagaagctta tctgcaaaag atataatgaa aaatgggaag agcaatcatc     2460

tcaaacagtt ccgggttgct gcccttttgg ctttcctagg tgctacagta gcaggctgtt     2520

ttcccctttt ccatagaggg gaatattctg catcacccct ttgtttgcca tttcctacag     2580

gtgaaacgcc atcattagga ttcactgtaa cgttagtgct attaaactca ctagcatttt     2640

tattaatggc cgttatctac actaagctat actgcaactt ggaaaaagag gacctctcag     2700

aaaactcaca atctagcatg attaagcatg tcgcttggct aatcttcacc aattgcatct     2760

ttttctgccc tgtggcgttt ttttcatttg caccattgat cactgcaatc tctatcagcc     2820

ccgaaataat gaagtctgtt actctgatat tttttccatt gcctgcttgc ctgaatccag     2880

tcctgtatgt tttcttcaac ccaaagttta aagaagactg gaagttactg aagcgacgtg     2940

ttaccaagaa aagtggatca gtttcagttt ccatcagtag ccaaggtggt tgtctggaac     3000

aggatttcta ctacgactgt ggcatgtact cacatttgca gggcaacctg actgtttgcg     3060

actgctgcga atcgtttctt ttaacaaagc cagtatcatg caaacacttg ataaaatcac     3120

acagctgtcc tgcattggca gtggcttctt gccaaagacc tgagggctac tggtccgact     3180

gtggcacaca gtcggcccac tctgattatg cagatgaaga agattccttt gtctcagaca     3240

gttctgacca ggtgcaggcc tgtggacgag cctgcttcta ccagagtaga ggattccctt     3300

tggtgcgcta tgcttacaat ctaccaagag ttaaagactg aactactgtg tgtgtaaccg     3360

tttcccccgt caaccaaaat cagtgtttat agagtgaacc ctattctcat ctttcatctg     3420

ggaagcactt ctgtaatcac tgcctggtgt cacttagaag aaggagaggt ggcagtttat     3480

ttctcaaacc agtcattttc aaagaacagg tgcctaaatt ataaattggt gaaaaatgca     3540

atgtccaagc aatgtatgat ctgtttgaaa caaatatatg acttgaaaag gatcttaggt     3600

gtagtagagc aatataatgt tagttttttc tgatccataa gaagcaaatt tatacctatt     3660

tgtgtattaa gcacaagata aagaacagct gttaatattt tttaaaaatc tattttaaaa     3720

tgtgattttc tataactgaa gaaaatatct tgctaatttt acctaatgtt tcatccttaa     3780

tctcaggaca acttactgca gggccaaaaa agggactgtc ccagctagaa ctgtgagagt     3840

atacataggc attactttat tatgttttca cttgccatcc ttgacataag agaactataa     3900

attttgttta agcaatttat aaatctaaaa cctgaagatg tttttaaaac aatattaaca     3960

gctgttaggt taaaaaaata gctggacatt tgttttcagt cattatacat tgctttggtc     4020

caatcagtaa ttttttctta agtgttttgt gattacacta ctagaaaaaa agtaaaaggc     4080

taattgctgt gtgggtttag tcgatttggc taaactacta actaatgtgg gggtttaata     4140

gtatctgagg gatttggtgg cttcatgtaa tgttctcatt aatgaatact tcctaatatc     4200

gttggctcta ctaatatttt ccaatttgct gggatgtcac ctagcaatag cttggattat     4260

atagaaagta aactgtggtc aatacttgca tttaattaga cgaaacgggg agtaattatg     4320

acacgaagta cttatgttta tttcttagtg agctggatta tcttgaacct gtgctattaa     4380

atggaaattt ccatacatct tccccatact attttttata aaagagccta ttcaatagct     4440

cagaggttga actctggtta aacaagataa tatgttatta ataaaaatag aagaagaaag     4500

aataaagctt agtcctgtgt ctttaaaaat taaaaatttt acttgattcc catctatggg     4560

ctttagacct attactgggt ggagtcttaa agttataatt gttcaatatg ttttttgaac     4620

agtgtgctaa atcaatagca aacccactgc catattagtt attctgaata tactaaaaaa     4680

atccagctag attgcagttt aataattaaa ctgtacatac tgtgcatata atgaattttt     4740

atcttatgta aattattttt agaacacaag ttgggaaatg tggcttctgt tcatttcgtt     4800

taattaaagc tacctcctaa actatagtgg ctgccagtag cagactgtta aattgtggtt     4860

tatatacttt ttgcattgta aatagtcttt gttgtacatt gtcagtgtaa taaaaacaga     4920

atctttgtat atcaaaatca tgtagtttgt ataaaatgtg ggaaggattt atttacagtg     4980

tgttgtaatt ttgtaaggcc aactatttac aagttttaaa aattgctatc atgtatattt     5040

acacatctga taaatattaa atcataactt ggtaagaaac tcctaattaa aaggtttttt     5100

ccaaaattca ggttattgaa aacttttcat tttattcatt taaaaactag aataacagat     5160

atataaaagt gttaatcttt gtgctatatg gtatgaaata caatattgta ctcagtgttt     5220

tgaattatta aagtttctag aaagcaaa                                        5248


<210>  735
<211>  951
<212>  PRT
<213>  Homo Sapiens

<400>  735

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
    530                 535                 540                 


Val Trp Phe Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile 
545                 550                 555                 560 


Leu Thr Thr Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe 
                565                 570                 575     


Ile Gly Leu Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly 
            580                 585                 590         


Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
        595                 600                 605             


Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu 
    610                 615                 620                 


Ala Val Phe Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr 
625                 630                 635                 640 


Val Glu Arg Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser 
                645                 650                 655     


Asn His Leu Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly 
            660                 665                 670         


Ala Thr Val Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser 
        675                 680                 685             


Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
    690                 695                 700                 


Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
705                 710                 715                 720 


Met Ala Val Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                725                 730                 735     


Leu Ser Glu Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu 
            740                 745                 750         


Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
        755                 760                 765             


Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
    770                 775                 780                 


Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
785                 790                 795                 800 


Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                805                 810                 815     


Arg Arg Val Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser 
            820                 825                 830         


Gln Gly Gly Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
        835                 840                 845             


Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
    850                 855                 860                 


Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
865                 870                 875                 880 


Cys Pro Ala Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp 
                885                 890                 895     


Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
            900                 905                 910         


Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
        915                 920                 925             


Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
    930                 935                 940                 


Asn Leu Pro Arg Val Lys Asp 
945                 950     


<210>  736
<211>  4307
<212>  DNA
<213>  Homo Sapiens

<400>  736
ggccattttt cttcctggtg tttgaatgac tcataaaatg agtttggagt ggtctgaagc       60

ctctgcctcc ttccttgaat gctttctaag aggggctgcc atgcaagaat atatgctgat      120

tttcccatac ggcgcctcat ctcccagaga tcttccttgg agaccctgga agatattgag      180

gagaacgccc ctctccggag atgtcgaact ctctcaggtt cacccagacc aaagaatttt      240

aagaagattc attttatcaa gaacatgcgg caacacgata ccaggaatgg cagaatagtc      300

cttatcagtg gcagaagatc cttctgtagt atattttcag tgctgccgta tcgcgacagt      360

acccaagtcg gggacttgaa gttggacgga ggaagacaat caactggtgc agtgagtttg      420

aaagagatca ttggtctgga aggtgtggag ctgggtgctg atgggaagac tgtttcctat      480

acccaatttc tgttacccac aaatgccttt ggagcccgga gaaataccat agactccacc      540

tcctctttct cccagttccg taacctgagc caccgcagcc tctccatagg ccgggcaagc      600

ggcacccagg ggagcctcga cacaggtagt gacctgggag actttatgga ctatgaccca      660

aatctcttgg atgaccccca gtggccttgt ggcaaacaca aacgcgttct gatcttccct      720

tcctacatga caacagtgat tgactacgtg aagccctcgg atctcaagaa ggacatgaac      780

gagaccttca aggagaagtt tcctcacatt aagctgacac tcagcaaaat taggagtctg      840

aaacgagaga tgcggaagct tgcgcaggag gactgtggcc ttgaggagcc cacggtggcc      900

atggccttcg tctactttga aaagctcgcc ctcaagggga aactcaacaa acagaaccgg      960

aagctgtgtg ctggggcatg tgtgctgtta gcagccaaaa ttggaagtga cctcaaaaaa     1020

cacgaagtca agcatttaat tgacaaactg gaagagaagt tccggctgaa caggcgagaa     1080

ctgattgcct ttgaattccc ggtgttagtg gccttggaat tcgccctcca cttgcccgag     1140

cacgaagtca tgccccacta cagacggctg gtccagagtt cctagcactg gccccgagga     1200

cagccaaggg ccatttcttc tcagcttggt ggagcagcac ttacttacta ctggaaatga     1260

aaaaaagtag aactcagaat accagacttt tcttcctctc gacatagttt ggggagaagc     1320

agtactagaa actttccaag gagtcttggg tgtgtagcca agaggagcca tgagctatgg     1380

actcctcaag cacgggaaga ggaggtgtgt gctgagaaca gagaggccct gccctctgtc     1440

cactagcgag aatccctagc tgccccagcc cagtctttct ccccggcatt cacaaacttt     1500

gcaagcgtgg tccagggcct tctccagatc tgttccaact tggagtgtga agggcttgag     1560

catacggggg aagagagtct gcagaagttg ggggaaaact tttaaaagat accctcattg     1620

tgtcaaagag tgtgccaatc tatttttgta tcagcattgg aagtgcactt tcccctgggg     1680

cgtgtgggtg tgtgaatgtg caagtgtctg agagatactg catcagccct agacccccag     1740

agccagtccc gccctttaca gagcagccct tagcctgggg ccatgggtca ggctgacctt     1800

caacaattat ttctagatga tttctggata agaattgctc tctcggtacc agacagtttg     1860

acatcctcca cccttagaaa atgactgaca ttgttttgtt actgctccta cccaccaagg     1920

ggataaagaa ggcgagttct gagtgttgga tgagtcagtc gcgtggaagg acgtggagcg     1980

tggcgctctg taacttcctg ccgtctgcca ccccgccacg tgtatttaac cctcgcactt     2040

tctccactgt ggagatggct ggggcggcgc cccacagtgt gtattcctgt cctctatgtt     2100

agagtgcatc agaagcacat ttactgtgct atctatatcg ctatataaaa gtgttttata     2160

aaaacccaga ataggagcac gacgcatgat tggtgtttga ggcgtttgcc agctgggaca     2220

aactgcgttt ggagctgtgg ttaagctgac taaggaggcg gtggctcttt cttaacattc     2280

ccacgtgccc agggctgttc atgcaagatt ttaatggtga cttgtcctgg cttactggga     2340

cagtctgtat gaggcatgtc accacactgt cgcctcatag ctgcaagaga gaggcaccag     2400

ctgaagttcc cctgactgaa gagagcctgt ggccatgtaa aaagagaatt aaactcttgt     2460

tgctttttgt atacctgtat gcgtttgtgt agacgtgtgt ctcaccagtc acctttgccc     2520

tgcattgctg atccccttgc gcacactgat tctagtgagg tcacagattc ggagcttcac     2580

acaccagccc agagaaaggg cgatggaacc gaaccgaggg tctgcagctt tcgttagcag     2640

agctgtcaga ttcttgacag tcttggagga tggagaaatt caagcagcag ctggtgaggg     2700

ccaaaacaga atacttggct tcttcagaat cttagattgc actgagttta gtcctaaata     2760

ttttgctaac aaatttcctt ggccagaatc agttgtaaga cagtgatttg ggtggtgggg     2820

ggagggagga gggagaggat atgattaatg tggtctcttt ggctgatcga aagctagatc     2880

aactggtact tagggcactt gctgtttata aagcaaaatt gagaaaatat tcaaggtgcc     2940

tccatcgcct gaactacaaa atgcccttgg ccttcctcac atggggtctg tcaccttgca     3000

tctctgataa gccatccacc ttcctggtca gtgcctacag ggggagagcc tttctgagaa     3060

gcaggtcctg tggtatctga gaatggtcta gagagctccc cactgcccat ctgcccccga     3120

atttcctgcc aagctctggg gagtggggtg gggggaggga cgtccgatgg atgacaggcc     3180

gccagcccag acgtggggag agaagcctga gtcctttcct gtgtgataaa atcaggctaa     3240

tttacttgga tttggggtga tttgtttggt ttttagcatt tatgaggtga gcccatgaag     3300

ttagtggtcc attacttttt aaagatgcat tttcatttta aactgtctcc tggcctgtgg     3360

atttgtggaa tggacagttt tgtgggtttt aatttatttg tgaggagtcg gggctgagaa     3420

ggcattttat caggaggtct ccttttgcac gtccatgaca tgagcttttc ggaggcaaag     3480

gaagtggagg agggtgagag atgcaggtca ctgccagagg cacctctgtg acacggaaca     3540

ttccagacac gtcgcagcct tgggcttcgg cgaggaggaa gtctgagcct gtgaagcgag     3600

aaggccaggc agtagactgg ctctgaggtt ttgccctttg acctcctcca cagagggcag     3660

cttcagcccc ttgtaagccc tgccccctct caggactgcc ctgaggcctc tccagtcctc     3720

cccacactca gagatctgtg gggaagctcc gcccagccac actccttggg ataatactag     3780

ccggttctgc ctgattcctt ttcccccgga gccagcctag ggggcccggg actcctctag     3840

tgagccttga ctgttaggta agagacagga agcagacaag ccaagaggtt gctgcagctg     3900

cccccaggag gaaacgggca gcagggagtg tggcccagcc cccactgtac ccctccaggg     3960

gcccgagccc ttgccagccc aatgacacct tgaagtcacc acttttcctt tcttgcccgc     4020

taataaaacc tatttaaaca ggaaattcat accaaatgca aatgggtttt gttttccttg     4080

gcattttgtt gttccgatca cagatttccc tgccagggtg tctgtggtta tcagctgcag     4140

gctcagcttg gggcggccgc ttcacacaag ccactctgta ccacgtgccc taccttagtg     4200

acgggagtaa ggagcttcct tcccctccat gtcattcctt cctgttccct tcattcccca     4260

acagcaaata aaactgttga atgctctgaa aaaaaaaaaa aaaaaaa                   4307


<210>  737
<211>  368
<212>  PRT
<213>  Homo Sapiens

<400>  737

Met Leu Ser Lys Arg Gly Cys His Ala Arg Ile Tyr Ala Asp Phe Pro 
1               5                   10                  15      


Ile Arg Arg Leu Ile Ser Gln Arg Ser Ser Leu Glu Thr Leu Glu Asp 
            20                  25                  30          


Ile Glu Glu Asn Ala Pro Leu Arg Arg Cys Arg Thr Leu Ser Gly Ser 
        35                  40                  45              


Pro Arg Pro Lys Asn Phe Lys Lys Ile His Phe Ile Lys Asn Met Arg 
    50                  55                  60                  


Gln His Asp Thr Arg Asn Gly Arg Ile Val Leu Ile Ser Gly Arg Arg 
65                  70                  75                  80  


Ser Phe Cys Ser Ile Phe Ser Val Leu Pro Tyr Arg Asp Ser Thr Gln 
                85                  90                  95      


Val Gly Asp Leu Lys Leu Asp Gly Gly Arg Gln Ser Thr Gly Ala Val 
            100                 105                 110         


Ser Leu Lys Glu Ile Ile Gly Leu Glu Gly Val Glu Leu Gly Ala Asp 
        115                 120                 125             


Gly Lys Thr Val Ser Tyr Thr Gln Phe Leu Leu Pro Thr Asn Ala Phe 
    130                 135                 140                 


Gly Ala Arg Arg Asn Thr Ile Asp Ser Thr Ser Ser Phe Ser Gln Phe 
145                 150                 155                 160 


Arg Asn Leu Ser His Arg Ser Leu Ser Ile Gly Arg Ala Ser Gly Thr 
                165                 170                 175     


Gln Gly Ser Leu Asp Thr Gly Ser Asp Leu Gly Asp Phe Met Asp Tyr 
            180                 185                 190         


Asp Pro Asn Leu Leu Asp Asp Pro Gln Trp Pro Cys Gly Lys His Lys 
        195                 200                 205             


Arg Val Leu Ile Phe Pro Ser Tyr Met Thr Thr Val Ile Asp Tyr Val 
    210                 215                 220                 


Lys Pro Ser Asp Leu Lys Lys Asp Met Asn Glu Thr Phe Lys Glu Lys 
225                 230                 235                 240 


Phe Pro His Ile Lys Leu Thr Leu Ser Lys Ile Arg Ser Leu Lys Arg 
                245                 250                 255     


Glu Met Arg Lys Leu Ala Gln Glu Asp Cys Gly Leu Glu Glu Pro Thr 
            260                 265                 270         


Val Ala Met Ala Phe Val Tyr Phe Glu Lys Leu Ala Leu Lys Gly Lys 
        275                 280                 285             


Leu Asn Lys Gln Asn Arg Lys Leu Cys Ala Gly Ala Cys Val Leu Leu 
    290                 295                 300                 


Ala Ala Lys Ile Gly Ser Asp Leu Lys Lys His Glu Val Lys His Leu 
305                 310                 315                 320 


Ile Asp Lys Leu Glu Glu Lys Phe Arg Leu Asn Arg Arg Glu Leu Ile 
                325                 330                 335     


Ala Phe Glu Phe Pro Val Leu Val Ala Leu Glu Phe Ala Leu His Leu 
            340                 345                 350         


Pro Glu His Glu Val Met Pro His Tyr Arg Arg Leu Val Gln Ser Ser 
        355                 360                 365             


<210>  738
<211>  1409
<212>  DNA
<213>  Homo Sapiens

<400>  738
cgacttcctc tttccagtgc atttaaggcg cagcctggaa gtgccaggga gcactggagg       60

ccacccagtc atgggggaca ccttcatccg tcacatcgcc ctgctgggct ttgagaagcg      120

cttcgtaccc agccagcact atgtgtacat gttcctggtg aaatggcagg acctgtcgga      180

gaaggtggtc taccggcgct tcaccgagat ctacgagttc cataaaacct taaaagaaat      240

gttccctatt gaggcagggg cgatcaatcc agagaacagg atcatccccc acctcccagc      300

tcccaagtgg tttgacgggc agcgggccgc cgagaaccgc cagggcacac ttaccgagta      360

ctgcggcacg ctcatgagcc tgcccaccaa gatctcccgc tgtccccacc tcctcgactt      420

cttcaaggtg cgccctgatg acctcaagct ccccacggac aaccagacaa aaaagccaga      480

gacatacttg atgcccaaag atggcaagag taccgcgaca gacatcaccg gccccatcat      540

cctgcagacg taccgcgcca ttgccaacta cgagaagacc tcgggctccg agatggctct      600

gtccacgggg gacgtggtgg aggtcgtaga gaagagcgag agcggttggt ggttctgtca      660

gatgaaagca aagcgaggct ggatcccagc gtccttcctc gagcccctgg acagtcctga      720

cgagacggaa gaccctgagc ccaactatgc aggtgagcca tacgtcgcca tcaaggccta      780

cactgctgtg gagggggacg aggtgtccct gctcgagggt gaagctgttg aggtcattca      840

caagctcctg gacggctggt gggtcatcag gaaagacgac gtcacaggct acttcccgtc      900

catgtacctg caaaagtcag ggcaagacgt gtcccaggcc caacgccaga tcaagcgggg      960

ggcgccgccc cgcaggtcgt ccatccgcaa cgcgcacagc atccaccagc ggtcgcggaa     1020

gcgcctcagc caggacgcct atcgccgcaa cagcgtccgt tttctgcagc agcgacgccg     1080

ccaggcgcgg ccgggaccgc agagccccgg gagcccgctc gaggaggagc ggcagacgca     1140

gcgctctaaa ccgcagccgg cggtgccccc gcggccgagc gccgacctca tcctgaaccg     1200

ctgcagcgag agcaccaagc ggaagctggc gtctgccgtc tgaggctgga gcgcagtccc     1260

cagctagcgt ctcggccctt gccgccccgt gcctgtacat acgtgttcta tagagcctgg     1320

cgtctggacg ccgagggcag ccccgacccc tgtccagcgc ggctcccgcc accctcaata     1380

aatgttgctt ggagtggaaa aaaaaaaaa                                       1409


<210>  739
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  739

Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly Phe Glu Lys 
1               5                   10                  15      


Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu Val Lys Trp 
            20                  25                  30          


Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr Glu Ile Tyr 
        35                  40                  45              


Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu Ala Gly Ala 
    50                  55                  60                  


Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala Pro Lys Trp 
65                  70                  75                  80  


Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr Leu Thr Glu 
                85                  90                  95      


Tyr Cys Gly Thr Leu Met Ser Leu Pro Thr Lys Ile Ser Arg Cys Pro 
            100                 105                 110         


His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu Lys Leu Pro 
        115                 120                 125             


Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met Pro Lys Asp 
    130                 135                 140                 


Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile Leu Gln Thr 
145                 150                 155                 160 


Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser Glu Met Ala 
                165                 170                 175     


Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser Glu Ser Gly 
            180                 185                 190         


Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile Pro Ala Ser 
        195                 200                 205             


Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp Pro Glu Pro 
    210                 215                 220                 


Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr Thr Ala Val 
225                 230                 235                 240 


Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val Glu Val Ile 
                245                 250                 255     


His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp Asp Val Thr 
            260                 265                 270         


Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln Asp Val Ser 
        275                 280                 285             


Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg Arg Ser Ser 
    290                 295                 300                 


Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys Arg Leu Ser 
305                 310                 315                 320 


Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln Gln Arg Arg 
                325                 330                 335     


Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro Leu Glu Glu 
            340                 345                 350         


Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val Pro Pro Arg 
        355                 360                 365             


Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser Thr Lys Arg 
    370                 375                 380                 


Lys Leu Ala Ser Ala Val 
385                 390 


<210>  740
<211>  2659
<212>  DNA
<213>  Homo Sapiens

<400>  740
ggcgagcgag cgggcggccg gccgctgggg gtggcgggat aggctgggcg cggccggcgc       60

tgcagacccg ctgctgttgt ccgggtctgt gcggtcccga gggccctccg tgccgccggc      120

gccatgggca attgccacac ggtggggccc aacgaggcgc tggtggtttc agggggctgt      180

tgtggttccg actataaaca gtacgtgttt ggcggctggg cctgggcctg gtggtgtatc      240

tccgacactc agaggatttc cctagagatt atgacgttgc agccccgctg cgaggacgta      300

gagacggccg agggggtagc tttaactgtg acgggtgtcg cccaggtgaa gatcatgacg      360

gagaaggaac tcctggccgt ggcttgtgag cagtttctgg gtaagaatgt gcaggacatc      420

aaaaacgtcg tcctgcagac cctggaggga catctgcgct ccatcctcgg gaccctgaca      480

gtggagcaga tttatcagga ccgggaccag tttgccaagc tggtgcggga ggtggcagcc      540

cctgatgttg gccgcatggg cattgagatc ctcagcttca ccatcaagga cgtgtatgac      600

aaagtggact atctgagctc cctgggcaag acgcagactg ccgtggtgca gagagatgct      660

gacattggcg tggccgaggc tgaacgggac gcaggcatcc gggaagctga gtgcaagaag      720

gagatgctgg atgtgaagtt catggcagac accaagattg ctgactctaa gcgagccttc      780

gagctgcaaa agtcagcctt cagtgaggag gttaacatca agacagctga ggcccagttg      840

gcctatgagc tgcagggggc ccgtgaacag cagaagatcc ggcaggaaga gattgagatt      900

gaggttgtgc agcgcaagaa acagattgcc gtggaggcac aggagatcct gcgtacggac      960

aaggagctca tcgctacagt gcgccggcct gccgaggccg aggcccaccg catccagcag     1020

attgccgagg gtgaaaaggt gaagcaggtc ctcttggcac aggcagaggc tgagaagatc     1080

cgcaaaatcg gggaggcgga agcggcagtc atcgaggcga tgggcaaggc agaggctgag     1140

cggatgaagc tcaaggcaga agcctaccag aaatacgggg atgcagccaa gatggccttg     1200

gtgctagagg ccctgcccca gattgctgcc aaaatcgctg ccccacttac caaggtcgat     1260

gagattgtgg tcctcagtgg agacaacagt aaggtcacat cagaagtgaa ccgactgctg     1320

gccgagctgc ctgcctctgt gcatgccctc acaggcgtgg acctgtctaa gatacccctg     1380

atcaagaagg ccactggtgt gcaggtgtga ggctcctgca ggcccactct cttcagcagc     1440

cacccggccc tccctccagc acccgtttta atcccacaga acaacgggaa cgttactgac     1500

tctggtgcct tatctcgaag ggaccagaag tgctgcgtgt tcaggccatc tctggctgtc     1560

ttcctgtctc tcctgtctgt ccacctcctc ctcttcctct cctttacccc actttcactg     1620

ccactttcat caggtttgtg tctcatctcc ctgcgtgtct tttcctttgt ctgtcttttt     1680

ctttccccca tgcacatcat gtagattaag ctgaagatgt ttattacaat cactctctgt     1740

ggggggtggc cctgctgctc ctcagaatcc tggtgccttg aagttctctg tgcatctgtc     1800

catcctccct atggccctgg ccagagctca gcatgggcag gggttctggg taggacggtc     1860

actgtcctct ctcctggact ggtcttccca gccctaaacc ctgccccagg aagcccacag     1920

cctcacctgc tgctgcccct ctaggtctgg gcagccatga cctgcagggc ccagagacac     1980

tgtccttccc ctcatccacc caaggcccca gccagcgctc ataccctgtc ctttctccct     2040

gaccccaagg gcacagaggc aaggcctcct gtctacagca gcttcctcag tttcctactg     2100

ccttaggagg cccctgcttg tgctcaggga aggcctcttc atgggcatgt tcctgctggg     2160

gcggtgcggt ttggtcccaa ctctgctaag ttttctgaga tgagggtcta gccctgttgg     2220

ggacagaaaa gtgtgtagac cttcttcctg ctagggctgc actgtcctgg gtgttgggcc     2280

cttctggtgg acaaggctgt gccaaccctg tacagaatcg agtgctgtag cctggccaga     2340

ccccagagcc cttgtgccat ctttcttcct ggccagagtg atggggttcc agccatgggg     2400

aagcaaccca atcctctgtc tccttgctcc aatggaggca gaagagccca ggacccaagc     2460

gtcttggcag gggtgctgtg aatgtccagt ggtcccagct ccccaccctg gccctgcccc     2520

agcctgtgta gctcttcctg catgtggatg ctgcatgtct ggtctggggc ttggatgttg     2580

cactgcccca ctgcctgtcc cttctggtaa aataaagaac tcttaatgcc caaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaa                                                  2659


<210>  741
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  741

Met Gly Asn Cys His Thr Val Gly Pro Asn Glu Ala Leu Val Val Ser 
1               5                   10                  15      


Gly Gly Cys Cys Gly Ser Asp Tyr Lys Gln Tyr Val Phe Gly Gly Trp 
            20                  25                  30          


Ala Trp Ala Trp Trp Cys Ile Ser Asp Thr Gln Arg Ile Ser Leu Glu 
        35                  40                  45              


Ile Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly 
    50                  55                  60                  


Val Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu 
65                  70                  75                  80  


Lys Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val 
                85                  90                  95      


Gln Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg 
            100                 105                 110         


Ser Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp 
        115                 120                 125             


Gln Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg 
    130                 135                 140                 


Met Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys 
145                 150                 155                 160 


Val Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln 
                165                 170                 175     


Arg Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile 
            180                 185                 190         


Arg Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala 
        195                 200                 205             


Asp Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser 
    210                 215                 220                 


Ala Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala 
225                 230                 235                 240 


Tyr Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu 
                245                 250                 255     


Ile Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala 
            260                 265                 270         


Gln Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg 
        275                 280                 285             


Pro Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu 
    290                 295                 300                 


Lys Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg 
305                 310                 315                 320 


Lys Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala 
                325                 330                 335     


Glu Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly 
            340                 345                 350         


Asp Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala 
        355                 360                 365             


Ala Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu 
    370                 375                 380                 


Ser Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys 
                405                 410                 415     


Ile Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
            420                 425             


<210>  742
<211>  6701
<212>  DNA
<213>  Homo Sapiens

<400>  742
aggggaggag agcggcccat ggacccgcgg ggcccggcgc cccagactct gcgccgtcgg       60

gacggagccc aagatgtcgg cctaggccgg ggcgcgacga cgcggacggg gcggcgagga      120

ggcgccgctg ctgccggggc tcgcagccgc cgagcccccg agggcgcgcc ctgacggact      180

ggccgagccg gcggtgagag gccggcgcgt cgggagcggg ccgcgcggca ccatgtcggc      240

caaggtgcgg ctcaagaagc tggagcagct gctcctggac gggccctggc gcaacgagag      300

cgccctgagc gtggaaacgc tgctcgacgt gctcgtctgc ctgtacaccg agtgcagcca      360

ctcggccctg cgccgcgaca agtacgtggc cgagttcctc gagtgggcta aaccatttac      420

acagctggtg aaagaaatgc agcttcatcg agaagacttt gaaataatta aagtaattgg      480

aagaggtgct tttggtgagg ttgctgttgt caaaatgaag aatactgaac gaatttatgc      540

aatgaaaatc ctcaacaagt gggagatgct gaaaagagca gagaccgcgt gcttccgaga      600

ggagcgcgat gtgctggtga acggcgactg ccagtggatc accgcgctgc actacgcctt      660

tcaggacgag aaccacctgt acttagtcat ggattactat gtgggtggtg atttactgac      720

cctgctcagc aaatttgaag acaagcttcc ggaagatatg gcgaggttct acattggtga      780

aatggtgctg gccattgact ccatccatca gcttcattac gtgcacagag acattaaacc      840

tgacaatgtc cttttggacg tgaatggtca tatccgcctg gctgactttg gatcatgttt      900

gaagatgaat gatgatggca ctgtgcagtc ctccgtggcc gtgggcacac ctgactacat      960

ctcgccggag atcctgcagg cgatggagga cggcatgggc aaatacgggc ctgagtgtga     1020

ctggtggtct ctgggtgtct gcatgtatga gatgctctat ggagaaacgc cgttttatgc     1080

ggagtcactc gtggagacct atgggaagat catgaaccat gaagagcgat tccagttccc     1140

atcccatgtc acggatgtat ctgaagaagc gaaggacctc atccagagac tgatctgcag     1200

tagagaacgc cggctggggc agaatggaat agaggatttc aaaaagcatg cgttttttga     1260

aggtctaaat tgggaaaata tacgaaacct agaagcacct tatattcctg atgtgagcag     1320

tccctctgac acatccaact tcgacgtgga tgacgacgtg ctgagaaaca cggaaatatt     1380

acctcctggt tctcacacag gcttttctgg attacatttg ccattcattg gttttacatt     1440

cacaacggaa agctgttttt ctgatcgagg ctctctgaag agcataatgc agtccaacac     1500

attaaccaaa gatgaggatg tgcagcggga cctggagcac agcctgcaga tggaagctta     1560

cgagaggagg attcggaggc tggaacagga gaagctggag ctgagcagga agctgcaaga     1620

gtccacccag accgtgcagt ccctccacgg ctcatctcgg gccctcagca attcaaaccg     1680

agataaagaa atcaaaaagc taaatgaaga aatcgaacgc ttgaagaata aaatagcaga     1740

ttcaaacagg ctcgagcgac agcttgagga cacagtggcg cttcgccaag agcgtgagga     1800

ctccacgcag cggctgcggg ggctggagaa gcagcaccgc gtggtccggc aggagaagga     1860

ggagctgcac aagcaactgg ttgaagcctc agagcggttg aaatcccagg ccaaggaact     1920

caaagatgcc catcagcagc gaaagctggc cctgcaggag ttctcggagc tgaacgagcg     1980

catggcagag ctccgtgccc agaagcagaa ggtgtcccgg cagctgcgag acaaggagga     2040

ggagatggag gtggccacgc agaaggtgga cgccatgcgg caggaaatgc ggagagctga     2100

gaagctcagg aaagagctgg aagctcagct tgatgatgct gttgctgagg cctccaagga     2160

gcgcaagctt cgtgagcaca gcgagaactt ctgcaagcaa atggaaagcg agctggaggc     2220

cctcaaggtg aagcaaggag gccggggagc gggtgccacc ttagagcacc agcaagagat     2280

ttccaaaatc aaatccgagc tggagaagaa agtcttattt tatgaagagg aattggtcag     2340

acgtgaggcc tcccatgtgc tagaagtgaa aaatgtgaag aaggaggtgc atgattcaga     2400

aagccaccag ctggccctgc agaaagaaat cttgatgtta aaagataagt tagaaaagtc     2460

aaagcgagaa cggcataacg agatggagga ggcagtaggt acaataaaag ataaatacga     2520

acgagaaaga gcgatgctgt ttgatgaaaa caagaagcta actgctgaaa atgaaaagct     2580

ctgttccttt gtggataaac tcacagctca aaatagacag ctggaggatg agctgcagga     2640

tctggcagcc aagaaggagt cagtggccca ctgggaagct cagattgcgg aaatcattca     2700

gtgggtcagt gacgagaaag atgcccgggg ttaccttcaa gctcttgctt ccaagatgac     2760

cgaagagctc gaggctttga ggagttctag tctggggtca agaacactgg acccgctgtg     2820

gaaggtgcgc cgcagccaga agctggacat gtccgcgcgg ctggagctgc agtcggccct     2880

ggaggcggag atccgggcca agcagcttgt ccaggaggag ctcaggaagg tcaaggacgc     2940

caacctcacc ttggaaagca aactaaagga ttccgaagcc aaaaacagag aattattaga     3000

agaaatggaa attttgaaga aaaagatgga agaaaaattc agagcagata ctgggctcaa     3060

acttccagat tttcaggatt ccatttttga gtatttcaac actgctcctc ttgcacatga     3120

cctgacattt agaaccagct cagctagtga gcaagaaaca caagctccga agccagaagc     3180

gtccccgtcg atgtctgtgg ctgcatcaga gcagcaggag gacatggctc ggcccccgca     3240

gaggccatcc gctgtgccgt tgcccaccac gcaggccctg gctctggctg gaccgaagcc     3300

aaaagctcac cagttcagca tcaagtcctt ctccagccct actcagtgca gccactgcac     3360

ctccctgatg gttgggctga tccggcaggg ctacgcctgc gaggtgtgtt cctttgcttg     3420

ccacgtgtcc tgcaaagacg gtgcccccca ggtgtgccca atacctcccg agcagtccaa     3480

gaggcctctg ggcgtggacg tgcagcgagg catcggaaca gcctacaaag gccatgtcaa     3540

ggtcccaaag cccacggggg tgaagaaggg atggcagcgc gcatatgcag tcgtctgtga     3600

ctgcaagctc ttcctgtatg atctgcctga aggaaaatcc acccagcctg gtgtcattgc     3660

gagccaagtc ttggatctca gagatgacga gttttccgtg agctcagtcc tggcctcaga     3720

tgtcattcat gctacacgcc gagatattcc atgtatattc agggtgacgg cctctctctt     3780

aggtgcacct tctaagacca gctcgctgct cattctgaca gaaaatgaga atgaaaagag     3840

gaagtgggtt gggattctag aaggactcca gtccatcctt cataaaaacc ggctgaggaa     3900

tcaggtcgtg catgttccct tggaagccta cgacagctcg ctgcctctca tcaaggccat     3960

cctgacagct gccatcgtgg atgcagacag gattgcagtc ggcctagaag aagggctcta     4020

tgtcatagag gtcacccgag atgtgatcgt ccgtgccgct gactgtaaga aggtacacca     4080

gatcgagctt gctcccaggg agaagatcgt aatcctcctc tgtggccgga accaccatgt     4140

gcacctctat ccgtggtcgt cccttgatgg agcggaaggc agctttgaca tcaagcttcc     4200

ggaaaccaaa ggctgccagc tcatggccac ggccacactc aagaggaact ctggcacctg     4260

cctgtttgtg gccgtgaaac ggctgatcct ttgctatgag atccagagaa cgaagccatt     4320

ccacagaaag ttcaatgaga ttgtggctcc cggcagcgtg cagtgcctgg cggtgctcag     4380

ggacaggctc tgtgtgggct acccttctgg gttctgcctg ctgagcatcc agggggacgg     4440

gcagcctcta aacctggtaa atcccaatga cccctcgctt gcgttcctct cacaacagtc     4500

ttttgatgcc ctttgtgctg tggagctcga aagcgaggag tacctgcttt gcttcagcca     4560

catgggactg tacgtggacc cgcaaggccg gagggcacgc gcgcaggagc tcatgtggcc     4620

tgcggctcct gtcgcctgta gttgcagccc cacccacgtc acggtgtaca gcgagtatgg     4680

cgtggacgtc tttgatgtgc gcaccatgga gtgggtgcag accatcggcc tgcggaggat     4740

aaggcccctg aactctgaag gcaccctcaa cctcctcaac tgcgagcctc cacgcttgat     4800

ctacttcaag agcaagttct cgggagcggt tctcaacgtg ccggacacct ccgacaacag     4860

caagaagcag atgctgcgca ccaggagcaa aaggcggttc gtcttcaagg tcccagagga     4920

agagagactg cagcagaggc gagagatgct tagagaccca gaattgagat ccaaaatgat     4980

atccaaccca accaacttca accacgtggc ccacatgggc ccaggcgacg gcatgcaggt     5040

gctcatggac ctgcctctga gtgctgtgcc cccctcccag gaggaaaggc cgggccccgc     5100

tcccaccaac ctggctcgcc agcctccatc caggaacaag ccctacatct cgtggccctc     5160

atcaggtgga tcggagccta gcgtgactgt gcctctgaga agtatgtctg atccagacca     5220

ggactttgac aaagagcctg attcggactc caccaaacac tcaactccat cgaatagctc     5280

caaccccagc ggcccaccga gccccaactc cccccacagg agccagctcc ccctcgaagg     5340

cctggagcag ccggcctgtg acacctgaag ccgccagctc gccacagggg ccagggagct     5400

ggagatggcc tccagcgtca gtgccaagac tgagcgggcc ctccagtgtt gtccaaggaa     5460

atgtagaatc actttgtaga tatggagatg aagaagacaa atctttatta taatattgat     5520

cagttttatg ccgcattgtt cgtggcagta gaccacatct gttcgtctgc acagctgtga     5580

ggcgatgctg ttccatctgc acatgaagga cccccataca gcctgtctcc cacccctgac     5640

aacccgagag ggcatatggg gccctgccaa caccacttcc tcagcagaaa cccgtcatga     5700

cgcggctgct tcggaagcag acatctgggg acacagcctc agtacccagt cttttcccta     5760

gttcctgaaa ctttcctagg accttaagag aatagtagga ggtcctatag cattcccagt     5820

gtcactagaa ttttgaagac aggaaagtgg aggttagtct gtggcctttt tttcatttag     5880

ccattgcaca gtcagctgca gaagtcctgc tgaccaccta gtcatggaca aaggcccagg     5940

accagtgaca ccctgcgtcc ctgtgtgcat taagttcatt ctgggtcgca gccatgaagt     6000

gtcaccagta tctactactg tgaagtcagc tgtgctgttt tccattcgct tccacggctt     6060

ctgcctcctg ccataaaacc agcgagtgtc gtggtgcagg caggccctgt ggcctgctgg     6120

gctgagggaa gtcagagccc cagggcgcca cgaagcagcc actgggatac cccaccccgc     6180

cccgccctgc ccgccccccc ccccaccagt cctgcccccg catggagccc ccgtgattag     6240

tagcccgtat gatcacgtag acccacccaa cacactcctg cacactggcc ccggcccacg     6300

gcacagcaat cccctgcgcg tggatttcac ctcacccttt gtaccagatg ttgagtgacc     6360

agctctgtgg ccctgtgtcg tcagaggctt gtgattaact gtggcggcag acacagcttg     6420

tccacagctt gggccaggct tcccctgtcc tcccaccggt cggctgcttg gcaaggctgt     6480

tcaggacgtg cacttcccca agtcggcact gagtggccca gcaccgccta gccctgccac     6540

cccactgccc tcctgggcct tctgctggat gggcacctgg ggggttctgg tttttacttt     6600

tttaatgtaa gtctcagtct ttgtaattaa ttattgaatt gtgagaacat ttttgaacaa     6660

tttacctgtc aataaagcag aagacggcag ttttaaagtt c                         6701


<210>  743
<211>  1711
<212>  PRT
<213>  Homo Sapiens

<400>  743

Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu Gln Leu Leu Leu Asp 
1               5                   10                  15      


Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val Glu Thr Leu Leu Asp 
            20                  25                  30          


Val Leu Val Cys Leu Tyr Thr Glu Cys Ser His Ser Ala Leu Arg Arg 
        35                  40                  45              


Asp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala Lys Pro Phe Thr Gln 
    50                  55                  60                  


Leu Val Lys Glu Met Gln Leu His Arg Glu Asp Phe Glu Ile Ile Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Met Lys 
                85                  90                  95      


Asn Thr Glu Arg Ile Tyr Ala Met Lys Ile Leu Asn Lys Trp Glu Met 
            100                 105                 110         


Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val Leu 
        115                 120                 125             


Val Asn Gly Asp Cys Gln Trp Ile Thr Ala Leu His Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp 
145                 150                 155                 160 


Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met 
                165                 170                 175     


Ala Arg Phe Tyr Ile Gly Glu Met Val Leu Ala Ile Asp Ser Ile His 
            180                 185                 190         


Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Val Leu Leu 
        195                 200                 205             


Asp Val Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys 
    210                 215                 220                 


Met Asn Asp Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr Pro 
225                 230                 235                 240 


Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Met Gly 
                245                 250                 255     


Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met Tyr 
            260                 265                 270         


Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val Glu 
        275                 280                 285             


Thr Tyr Gly Lys Ile Met Asn His Glu Glu Arg Phe Gln Phe Pro Ser 
    290                 295                 300                 


His Val Thr Asp Val Ser Glu Glu Ala Lys Asp Leu Ile Gln Arg Leu 
305                 310                 315                 320 


Ile Cys Ser Arg Glu Arg Arg Leu Gly Gln Asn Gly Ile Glu Asp Phe 
                325                 330                 335     


Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp Glu Asn Ile Arg Asn 
            340                 345                 350         


Leu Glu Ala Pro Tyr Ile Pro Asp Val Ser Ser Pro Ser Asp Thr Ser 
        355                 360                 365             


Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn Thr Glu Ile Leu Pro 
    370                 375                 380                 


Pro Gly Ser His Thr Gly Phe Ser Gly Leu His Leu Pro Phe Ile Gly 
385                 390                 395                 400 


Phe Thr Phe Thr Thr Glu Ser Cys Phe Ser Asp Arg Gly Ser Leu Lys 
                405                 410                 415     


Ser Ile Met Gln Ser Asn Thr Leu Thr Lys Asp Glu Asp Val Gln Arg 
            420                 425                 430         


Asp Leu Glu His Ser Leu Gln Met Glu Ala Tyr Glu Arg Arg Ile Arg 
        435                 440                 445             


Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu Ser 
    450                 455                 460                 


Thr Gln Thr Val Gln Ser Leu His Gly Ser Ser Arg Ala Leu Ser Asn 
465                 470                 475                 480 


Ser Asn Arg Asp Lys Glu Ile Lys Lys Leu Asn Glu Glu Ile Glu Arg 
                485                 490                 495     


Leu Lys Asn Lys Ile Ala Asp Ser Asn Arg Leu Glu Arg Gln Leu Glu 
            500                 505                 510         


Asp Thr Val Ala Leu Arg Gln Glu Arg Glu Asp Ser Thr Gln Arg Leu 
        515                 520                 525             


Arg Gly Leu Glu Lys Gln His Arg Val Val Arg Gln Glu Lys Glu Glu 
    530                 535                 540                 


Leu His Lys Gln Leu Val Glu Ala Ser Glu Arg Leu Lys Ser Gln Ala 
545                 550                 555                 560 


Lys Glu Leu Lys Asp Ala His Gln Gln Arg Lys Leu Ala Leu Gln Glu 
                565                 570                 575     


Phe Ser Glu Leu Asn Glu Arg Met Ala Glu Leu Arg Ala Gln Lys Gln 
            580                 585                 590         


Lys Val Ser Arg Gln Leu Arg Asp Lys Glu Glu Glu Met Glu Val Ala 
        595                 600                 605             


Thr Gln Lys Val Asp Ala Met Arg Gln Glu Met Arg Arg Ala Glu Lys 
    610                 615                 620                 


Leu Arg Lys Glu Leu Glu Ala Gln Leu Asp Asp Ala Val Ala Glu Ala 
625                 630                 635                 640 


Ser Lys Glu Arg Lys Leu Arg Glu His Ser Glu Asn Phe Cys Lys Gln 
                645                 650                 655     


Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys Gln Gly Gly Arg Gly 
            660                 665                 670         


Ala Gly Ala Thr Leu Glu His Gln Gln Glu Ile Ser Lys Ile Lys Ser 
        675                 680                 685             


Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu Glu Leu Val Arg Arg 
    690                 695                 700                 


Glu Ala Ser His Val Leu Glu Val Lys Asn Val Lys Lys Glu Val His 
705                 710                 715                 720 


Asp Ser Glu Ser His Gln Leu Ala Leu Gln Lys Glu Ile Leu Met Leu 
                725                 730                 735     


Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg His Asn Glu Met Glu 
            740                 745                 750         


Glu Ala Val Gly Thr Ile Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met 
        755                 760                 765             


Leu Phe Asp Glu Asn Lys Lys Leu Thr Ala Glu Asn Glu Lys Leu Cys 
    770                 775                 780                 


Ser Phe Val Asp Lys Leu Thr Ala Gln Asn Arg Gln Leu Glu Asp Glu 
785                 790                 795                 800 


Leu Gln Asp Leu Ala Ala Lys Lys Glu Ser Val Ala His Trp Glu Ala 
                805                 810                 815     


Gln Ile Ala Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp Ala Arg 
            820                 825                 830         


Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu Glu Ala 
        835                 840                 845             


Leu Arg Ser Ser Ser Leu Gly Ser Arg Thr Leu Asp Pro Leu Trp Lys 
    850                 855                 860                 


Val Arg Arg Ser Gln Lys Leu Asp Met Ser Ala Arg Leu Glu Leu Gln 
865                 870                 875                 880 


Ser Ala Leu Glu Ala Glu Ile Arg Ala Lys Gln Leu Val Gln Glu Glu 
                885                 890                 895     


Leu Arg Lys Val Lys Asp Ala Asn Leu Thr Leu Glu Ser Lys Leu Lys 
            900                 905                 910         


Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu Glu Met Glu Ile Leu 
        915                 920                 925             


Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp Thr Gly Leu Lys Leu 
    930                 935                 940                 


Pro Asp Phe Gln Asp Ser Ile Phe Glu Tyr Phe Asn Thr Ala Pro Leu 
945                 950                 955                 960 


Ala His Asp Leu Thr Phe Arg Thr Ser Ser Ala Ser Glu Gln Glu Thr 
                965                 970                 975     


Gln Ala Pro Lys Pro Glu Ala Ser Pro Ser Met Ser Val Ala Ala Ser 
            980                 985                 990         


Glu Gln Gln Glu Asp Met Ala Arg  Pro Pro Gln Arg Pro  Ser Ala Val 
        995                 1000                 1005             


Pro Leu  Pro Thr Thr Gln Ala  Leu Ala Leu Ala Gly  Pro Lys Pro 
    1010                 1015                 1020             


Lys Ala  His Gln Phe Ser Ile  Lys Ser Phe Ser Ser  Pro Thr Gln 
    1025                 1030                 1035             


Cys Ser  His Cys Thr Ser Leu  Met Val Gly Leu Ile  Arg Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Cys Glu Val Cys Ser  Phe Ala Cys His Val  Ser Cys Lys 
    1055                 1060                 1065             


Asp Gly  Ala Pro Gln Val Cys  Pro Ile Pro Pro Glu  Gln Ser Lys 
    1070                 1075                 1080             


Arg Pro  Leu Gly Val Asp Val  Gln Arg Gly Ile Gly  Thr Ala Tyr 
    1085                 1090                 1095             


Lys Gly  His Val Lys Val Pro  Lys Pro Thr Gly Val  Lys Lys Gly 
    1100                 1105                 1110             


Trp Gln  Arg Ala Tyr Ala Val  Val Cys Asp Cys Lys  Leu Phe Leu 
    1115                 1120                 1125             


Tyr Asp  Leu Pro Glu Gly Lys  Ser Thr Gln Pro Gly  Val Ile Ala 
    1130                 1135                 1140             


Ser Gln  Val Leu Asp Leu Arg  Asp Asp Glu Phe Ser  Val Ser Ser 
    1145                 1150                 1155             


Val Leu  Ala Ser Asp Val Ile  His Ala Thr Arg Arg  Asp Ile Pro 
    1160                 1165                 1170             


Cys Ile  Phe Arg Val Thr Ala  Ser Leu Leu Gly Ala  Pro Ser Lys 
    1175                 1180                 1185             


Thr Ser  Ser Leu Leu Ile Leu  Thr Glu Asn Glu Asn  Glu Lys Arg 
    1190                 1195                 1200             


Lys Trp  Val Gly Ile Leu Glu  Gly Leu Gln Ser Ile  Leu His Lys 
    1205                 1210                 1215             


Asn Arg  Leu Arg Asn Gln Val  Val His Val Pro Leu  Glu Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Ser Leu Pro Leu Ile  Lys Ala Ile Leu Thr  Ala Ala Ile 
    1235                 1240                 1245             


Val Asp  Ala Asp Arg Ile Ala  Val Gly Leu Glu Glu  Gly Leu Tyr 
    1250                 1255                 1260             


Val Ile  Glu Val Thr Arg Asp  Val Ile Val Arg Ala  Ala Asp Cys 
    1265                 1270                 1275             


Lys Lys  Val His Gln Ile Glu  Leu Ala Pro Arg Glu  Lys Ile Val 
    1280                 1285                 1290             


Ile Leu  Leu Cys Gly Arg Asn  His His Val His Leu  Tyr Pro Trp 
    1295                 1300                 1305             


Ser Ser  Leu Asp Gly Ala Glu  Gly Ser Phe Asp Ile  Lys Leu Pro 
    1310                 1315                 1320             


Glu Thr  Lys Gly Cys Gln Leu  Met Ala Thr Ala Thr  Leu Lys Arg 
    1325                 1330                 1335             


Asn Ser  Gly Thr Cys Leu Phe  Val Ala Val Lys Arg  Leu Ile Leu 
    1340                 1345                 1350             


Cys Tyr  Glu Ile Gln Arg Thr  Lys Pro Phe His Arg  Lys Phe Asn 
    1355                 1360                 1365             


Glu Ile  Val Ala Pro Gly Ser  Val Gln Cys Leu Ala  Val Leu Arg 
    1370                 1375                 1380             


Asp Arg  Leu Cys Val Gly Tyr  Pro Ser Gly Phe Cys  Leu Leu Ser 
    1385                 1390                 1395             


Ile Gln  Gly Asp Gly Gln Pro  Leu Asn Leu Val Asn  Pro Asn Asp 
    1400                 1405                 1410             


Pro Ser  Leu Ala Phe Leu Ser  Gln Gln Ser Phe Asp  Ala Leu Cys 
    1415                 1420                 1425             


Ala Val  Glu Leu Glu Ser Glu  Glu Tyr Leu Leu Cys  Phe Ser His 
    1430                 1435                 1440             


Met Gly  Leu Tyr Val Asp Pro  Gln Gly Arg Arg Ala  Arg Ala Gln 
    1445                 1450                 1455             


Glu Leu  Met Trp Pro Ala Ala  Pro Val Ala Cys Ser  Cys Ser Pro 
    1460                 1465                 1470             


Thr His  Val Thr Val Tyr Ser  Glu Tyr Gly Val Asp  Val Phe Asp 
    1475                 1480                 1485             


Val Arg  Thr Met Glu Trp Val  Gln Thr Ile Gly Leu  Arg Arg Ile 
    1490                 1495                 1500             


Arg Pro  Leu Asn Ser Glu Gly  Thr Leu Asn Leu Leu  Asn Cys Glu 
    1505                 1510                 1515             


Pro Pro  Arg Leu Ile Tyr Phe  Lys Ser Lys Phe Ser  Gly Ala Val 
    1520                 1525                 1530             


Leu Asn  Val Pro Asp Thr Ser  Asp Asn Ser Lys Lys  Gln Met Leu 
    1535                 1540                 1545             


Arg Thr  Arg Ser Lys Arg Arg  Phe Val Phe Lys Val  Pro Glu Glu 
    1550                 1555                 1560             


Glu Arg  Leu Gln Gln Arg Arg  Glu Met Leu Arg Asp  Pro Glu Leu 
    1565                 1570                 1575             


Arg Ser  Lys Met Ile Ser Asn  Pro Thr Asn Phe Asn  His Val Ala 
    1580                 1585                 1590             


His Met  Gly Pro Gly Asp Gly  Met Gln Val Leu Met  Asp Leu Pro 
    1595                 1600                 1605             


Leu Ser  Ala Val Pro Pro Ser  Gln Glu Glu Arg Pro  Gly Pro Ala 
    1610                 1615                 1620             


Pro Thr  Asn Leu Ala Arg Gln  Pro Pro Ser Arg Asn  Lys Pro Tyr 
    1625                 1630                 1635             


Ile Ser  Trp Pro Ser Ser Gly  Gly Ser Glu Pro Ser  Val Thr Val 
    1640                 1645                 1650             


Pro Leu  Arg Ser Met Ser Asp  Pro Asp Gln Asp Phe  Asp Lys Glu 
    1655                 1660                 1665             


Pro Asp  Ser Asp Ser Thr Lys  His Ser Thr Pro Ser  Asn Ser Ser 
    1670                 1675                 1680             


Asn Pro  Ser Gly Pro Pro Ser  Pro Asn Ser Pro His  Arg Ser Gln 
    1685                 1690                 1695             


Leu Pro  Leu Glu Gly Leu Glu  Gln Pro Ala Cys Asp  Thr 
    1700                 1705                 1710     


<210>  744
<211>  14905
<212>  DNA
<213>  Homo Sapiens

<400>  744
cagcggtgcg agctccaggc ccatgcactg aggaggcgga aacaagggga gcccccagag       60

ctccatcaag ccccctccaa aggctcccct acccggtcca cgccccccac cccccctccc      120

cgcctcctcc caattgtgca tttttgcagc cggaggcggc tccgagatgg ggctgtgagc      180

ttcgcccggg gagggggaaa gagcagcgag gagtgaagcg ggggggtggg gtgaagggtt      240

tggatttcgg ggcagggggc gcacccccgt cagcaggccc tccccaaggg gctcggaact      300

ctacctcttc acccacgccc ctggtgcgct ttgccgaagg aaagaataag aacagagaag      360

gaggaggggg aaaggaggaa aagggggacc ccccaactgg ggggggtgaa ggagagaagt      420

agcaggacca gaggggaagg ggctgctgct tgcatcagcc cacaccatgc tgaccccgcc      480

gttgctcctg ctgctgcccc tgctctcagc tctggtcgcg gcggctatcg acgcccctaa      540

gacttgcagc cccaagcagt ttgcctgcag agatcaaata acctgtatct caaagggctg      600

gcggtgcgac ggtgagaggg actgcccaga cggatctgac gaggcccctg agatttgtcc      660

acagagtaag gcccagcgat gccagccaaa cgagcataac tgcctgggta ctgagctgtg      720

tgttcccatg tcccgcctct gcaatggggt ccaggactgc atggacggct cagatgaggg      780

gccccactgc cgagagctcc aaggcaactg ctctcgcctg ggctgccagc accattgtgt      840

ccccacactc gatgggccca cctgctactg caacagcagc tttcagcttc aggcagatgg      900

caagacctgc aaagattttg atgagtgctc agtgtacggc acctgcagcc agctatgcac      960

caacacagac ggctccttca tatgtggctg tgttgaagga tacctcctgc agccggataa     1020

ccgctcctgc aaggccaaga acgagccagt agaccggccc cctgtgctgt tgatagccaa     1080

ctcccagaac atcttggcca cgtacctgag tggggcccag gtgtctacca tcacacctac     1140

gagcacgcgg cagaccacag ccatggactt cagctatgcc aacgagaccg tatgctgggt     1200

gcatgttggg gacagtgctg ctcagacgca gctcaagtgt gcccgcatgc ctggcctaaa     1260

gggcttcgtg gatgagcaca ccatcaacat ctccctcagt ctgcaccacg tggaacagat     1320

ggccatcgac tggctgacag gcaacttcta ctttgtggat gacatcgatg ataggatctt     1380

tgtctgcaac agaaatgggg acacatgtgt cacattgcta gacctggaac tctacaaccc     1440

caagggcatt gccctggacc ctgccatggg gaaggtgttt ttcactgact atgggcagat     1500

cccaaaggtg gaacgctgtg acatggatgg gcagaaccgc accaagctcg tcgacagcaa     1560

gattgtgttt cctcatggca tcacgctgga cctggtcagc cgccttgtct actgggcaga     1620

tgcctatctg gactatattg aagtggtgga ctatgagggc aagggccgcc agaccatcat     1680

ccagggcatc ctgattgagc acctgtacgg cctgactgtg tttgagaatt atctctatgc     1740

caccaactcg gacaatgcca atgcccagca gaagacgagt gtgatccgtg tgaaccgctt     1800

taacagcacc gagtaccagg ttgtcacccg ggtggacaag ggtggtgccc tccacatcta     1860

ccaccagagg cgtcagcccc gagtgaggag ccatgcctgt gaaaacgacc agtatgggaa     1920

gccgggtggc tgctctgaca tctgcctgct ggccaacagc cacaaggcgc ggacctgccg     1980

ctgccgttcc ggcttcagcc tgggcagtga cgggaagtca tgcaagaagc cggagcatga     2040

gctgttcctc gtgtatggca agggccggcc aggcatcatc cggggcatgg atatgggggc     2100

caaggtcccg gatgagcaca tgatccccat tgaaaacctc atgaaccccc gagccctgga     2160

cttccacgct gagaccggct tcatctactt tgccgacacc accagctacc tcattggccg     2220

ccagaagatt gatggcactg agcgggagac catcctgaag gacggcatcc acaatgtgga     2280

gggtgtggcc gtggactgga tgggagacaa tctgtactgg acggacgatg ggcccaaaaa     2340

gacaatcagc gtggccaggc tggagaaagc tgctcagacc cgcaagactt taatcgaggg     2400

caaaatgaca caccccaggg ctattgtggt ggatccactc aatgggtgga tgtactggac     2460

agactgggag gaggacccca aggacagtcg gcgtgggcgg ctggagaggg cgtggatgga     2520

tggctcacac cgagacatct ttgtcacctc caagacagtg ctttggccca atgggctaag     2580

cctggacatc ccggctgggc gcctctactg ggtggatgcc ttctacgacc gcatcgagac     2640

gatactgctc aatggcacag accggaagat tgtgtatgaa ggtcctgagc tgaaccacgc     2700

ctttggcctg tgtcaccatg gcaactacct cttctggact gagtatcgga gtggcagtgt     2760

ctaccgcttg gaacggggtg taggaggcgc accccccact gtgacccttc tgcgcagtga     2820

gcggcccccc atctttgaga tccgaatgta tgatgcccag cagcagcaag ttggcaccaa     2880

caaatgccgg gtgaacaatg gcggctgcag cagcctgtgc ttggccaccc ctgggagccg     2940

ccagtgcgcc tgtgctgagg accaggtgtt ggacgcagac ggcgtcactt gcttggcgaa     3000

cccatcctac gtgcctccac cccagtgcca gccaggcgag tttgcctgtg ccaacagccg     3060

ctgcatccag gagcgctgga agtgtgacgg agacaacgat tgcctggaca acagtgatga     3120

ggccccagcc ctctgccatc agcacacctg cccctcggac cgattcaagt gcgagaacaa     3180

ccggtgcatc cccaaccgct ggctctgcga cggggacaat gactgtggga acagtgaaga     3240

tgagtccaat gccacttgtt cagcccgcac ctgccccccc aaccagttct cctgtgccag     3300

tggccgctgc atccccatct cctggacgtg tgatctggat gacgactgtg gggaccgctc     3360

tgatgagtct gcttcgtgtg cctatcccac ctgcttcccc ctgactcagt ttacctgcaa     3420

caatggcaga tgtatcaaca tcaactggag atgcgacaat gacaatgact gtggggacaa     3480

cagtgacgaa gccggctgca gccactcctg ttctagcacc cagttcaagt gcaacagcgg     3540

gcgttgcatc cccgagcact ggacctgcga tggggacaat gactgcggag actacagtga     3600

tgagacacac gccaactgca ccaaccaggc cacgaggccc cctggtggct gccacactga     3660

tgagttccag tgccggctgg atggactatg catccccctg cggtggcgct gcgatgggga     3720

cactgactgc atggactcca gcgatgagaa gagctgtgag ggagtgaccc acgtctgcga     3780

tcccagtgtc aagtttggct gcaaggactc agctcggtgc atcagcaaag cgtgggtgtg     3840

tgatggcgac aatgactgtg aggataactc ggacgaggag aactgcgagt ccctggcctg     3900

caggccaccc tcgcaccctt gtgccaacaa cacctcagtc tgcctgcccc ctgacaagct     3960

gtgtgatggc aacgacgact gtggcgacgg ctcagatgag ggcgagctct gcgaccagtg     4020

ctctctgaat aacggtggct gcagccacaa ctgctcagtg gcacctggcg aaggcattgt     4080

gtgttcctgc cctctgggca tggagctggg gcccgacaac cacacctgcc agatccagag     4140

ctactgtgcc aagcatctca aatgcagcca aaagtgcgac cagaacaagt tcagcgtgaa     4200

gtgctcctgc tacgagggct gggtcctgga acctgacggc gagagctgcc gcagcctgga     4260

ccccttcaag ccgttcatca ttttctccaa ccgccatgaa atccggcgca tcgatcttca     4320

caaaggagac tacagcgtcc tggtgcccgg cctgcgcaac accatcgccc tggacttcca     4380

cctcagccag agcgccctct actggaccga cgtggtggag gacaagatct accgcgggaa     4440

gctgctggac aacggagccc tgactagttt cgaggtggtg attcagtatg gcctggccac     4500

acccgagggc ctggctgtag actggattgc aggcaacatc tactgggtgg agagtaacct     4560

ggatcagatc gaggtggcca agctggatgg gaccctccgg accaccctgc tggccggtga     4620

cattgagcac ccaagggcaa tcgcactgga tccccgggat gggatcctgt tttggacaga     4680

ctgggatgcc agcctgcccc gcattgaggc agcctccatg agtggggctg ggcgccgcac     4740

cgtgcaccgg gagaccggct ctgggggctg gcccaacggg ctcaccgtgg actacctgga     4800

gaagcgcatc ctttggattg acgccaggtc agatgccatt tactcagccc gttacgacgg     4860

ctctggccac atggaggtgc ttcggggaca cgagttcctg tcgcacccgt ttgcagtgac     4920

gctgtacggg ggggaggtct actggactga ctggcgaaca aacacactgg ctaaggccaa     4980

caagtggacc ggccacaatg tcaccgtggt acagaggacc aacacccagc cctttgacct     5040

gcaggtgtac cacccctccc gccagcccat ggctcccaat ccctgtgagg ccaatggggg     5100

ccagggcccc tgctcccacc tgtgtctcat caactacaac cggaccgtgt cctgcgcctg     5160

cccccacctc atgaagctcc acaaggacaa caccacctgc tatgagttta agaagttcct     5220

gctgtacgca cgtcagatgg agatccgagg tgtggacctg gatgctccct actacaacta     5280

catcatctcc ttcacggtgc ccgacatcga caacgtcaca gtgctagact acgatgcccg     5340

cgagcagcgt gtgtactggt ctgacgtgcg gacacaggcc atcaagcggg ccttcatcaa     5400

cggcacaggc gtggagacag tcgtctctgc agacttgcca aatgcccacg ggctggctgt     5460

ggactgggtc tcccgaaacc tgttctggac aagctatgac accaataaga agcagatcaa     5520

tgtggcccgg ctggatggct ccttcaagaa cgcagtggtg cagggcctgg agcagcccca     5580

tggccttgtc gtccaccctc tgcgtgggaa gctctactgg accgatggtg acaacatcag     5640

catggccaac atggatggca gcaatcgcac cctgctcttc agtggccaga agggccccgt     5700

gggcctggct attgacttcc ctgaaagcaa actctactgg atcagctccg ggaaccatac     5760

catcaaccgc tgcaacctgg atgggagtgg gctggaggtc atcgatgcca tgcggagcca     5820

gctgggcaag gccaccgccc tggccatcat gggggacaag ctgtggtggg ctgatcaggt     5880

gtcggaaaag atgggcacat gcagcaaggc tgacggctcg ggctccgtgg tccttcggaa     5940

cagcaccacc ctggtgatgc acatgaaggt ctatgacgag agcatccagc tggaccataa     6000

gggcaccaac ccctgcagtg tcaacaacgg tgactgctcc cagctctgcc tgcccacgtc     6060

agagacgacc cgctcctgca tgtgcacagc cggctatagc ctccggagtg gccagcaggc     6120

ctgcgagggc gtaggttcct ttctcctgta ctctgtgcat gagggaatca ggggaattcc     6180

cctggatccc aatgacaagt cagatgccct ggtcccagtg tccgggacct cgctggctgt     6240

cggcatcgac ttccacgctg aaaatgacac catctactgg gtggacatgg gcctgagcac     6300

gatcagccgg gccaagcggg accagacgtg gcgtgaagac gtggtgacca atggcattgg     6360

ccgtgtggag ggcattgcag tggactggat cgcaggcaac atctactgga cagaccaggg     6420

ctttgatgtc atcgaggtcg cccggctcaa tggctccttc cgctacgtgg tgatctccca     6480

gggtctagac aagccccggg ccatcaccgt ccacccggag aaagggtact tgttctggac     6540

tgagtggggt cagtatccgc gtattgagcg gtctcggcta gatggcacgg agcgtgtggt     6600

gctggtcaac gtcagcatca gctggcccaa cggcatctca gtggactacc aggatgggaa     6660

gctgtactgg tgcgatgcac ggacagacaa gattgaacgg atcgacctgg agacaggtga     6720

gaaccgcgag gtggttctgt ccagcaacaa catggacatg ttttcagtgt ctgtgtttga     6780

ggatttcatc tactggagtg acaggactca tgccaacggc tctatcaagc gcgggagcaa     6840

agacaatgcc acagactccg tgcccctgcg aaccggcatc ggcgtccagc ttaaagacat     6900

caaagtcttc aaccgggacc ggcagaaagg caccaacgtg tgcgcggtgg ccaatggcgg     6960

gtgccagcag ctgtgcctgt accggggccg tgggcagcgg gcctgcgcct gtgcccacgg     7020

gatgctggct gaagacggag catcgtgccg cgagtatgcc ggctacctgc tctactcaga     7080

gcgcaccatt ctcaagagta tccacctgtc ggatgagcgc aacctcaatg cgcccgtgca     7140

gcccttcgag gaccctgagc acatgaagaa cgtcatcgcc ctggcctttg actaccgggc     7200

aggcacctct ccgggcaccc ccaatcgcat cttcttcagc gacatccact ttgggaacat     7260

ccaacagatc aacgacgatg gctccaggag gatcaccatt gtggaaaacg tgggctccgt     7320

ggaaggcctg gcctatcacc gtggctggga cactctctat tggacaagct acacgacatc     7380

caccatcacg cgccacacag tggaccagac ccgcccaggg gccttcgagc gtgagaccgt     7440

catcactatg tctggagatg accacccacg ggccttcgtt ttggacgagt gccagaacct     7500

catgttctgg accaactgga atgagcagca tcccagcatc atgcgggcgg cgctctcggg     7560

agccaatgtc ctgaccctta tcgagaagga catccgtacc cccaatggcc tggccatcga     7620

ccaccgtgcc gagaagctct acttctctga cgccaccctg gacaagatcg agcggtgcga     7680

gtatgacggc tcccaccgct atgtgatcct aaagtcagag cctgtccacc ccttcgggct     7740

ggccgtgtat ggggagcaca ttttctggac tgactgggtg cggcgggcag tgcagcgggc     7800

caacaagcac gtgggcagca acatgaagct gctgcgcgtg gacatccccc agcagcccat     7860

gggcatcatc gccgtggcca acgacaccaa cagctgtgaa ctctctccat gccgaatcaa     7920

caacggtggc tgccaggacc tgtgtctgct cactcaccag ggccatgtca actgctcatg     7980

ccgagggggc cgaatcctcc aggatgacct cacctgccga gcggtgaatt cctcttgccg     8040

agcacaagat gagtttgagt gtgccaatgg cgagtgcatc aacttcagcc tgacctgcga     8100

cggcgtcccc cactgcaagg acaagtccga tgagaagcca tcctactgca actcccgccg     8160

ctgcaagaag actttccggc agtgcagcaa tgggcgctgt gtgtccaaca tgctgtggtg     8220

caacggggcc gacgactgtg gggatggctc tgacgagatc ccttgcaaca agacagcctg     8280

tggtgtgggc gagttccgct gccgggacgg gacctgcatc gggaactcca gccgctgcaa     8340

ccagtttgtg gattgtgagg acgcctcaga tgagatgaac tgcagtgcca ccgactgcag     8400

cagctacttc cgcctgggcg tgaagggcgt gctcttccag ccctgcgagc ggacctcact     8460

ctgctacgca cccagctggg tgtgtgatgg cgccaatgac tgtggggact acagtgatga     8520

gcgcgactgc ccaggtgtga aacgccccag atgccctctg aattacttcg cctgccctag     8580

tgggcgctgc atccccatga gctggacgtg tgacaaagag gatgactgtg aacatggcga     8640

ggacgagacc cactgcaaca agttctgctc agaggcccag tttgagtgcc agaaccatcg     8700

ctgcatctcc aagcagtggc tgtgtgacgg cagcgatgac tgtggggatg gctcagacga     8760

ggctgctcac tgtgaaggca agacgtgcgg cccctcctcc ttctcctgcc ctggcaccca     8820

cgtgtgcgtc cccgagcgct ggctctgtga cggtgacaaa gactgtgctg atggtgcaga     8880

cgagagcatc gcagctggtt gcttgtacaa cagcacttgt gacgaccgtg agttcatgtg     8940

ccagaaccgc cagtgcatcc ccaagcactt cgtgtgtgac cacgaccgtg actgtgcaga     9000

tggctctgat gagtcccccg agtgtgagta cccgacctgc ggccccagtg agttccgctg     9060

tgccaatggg cgctgtctga gctcccgcca gtgggagtgt gatggcgaga atgactgcca     9120

cgaccagagt gacgaggctc ccaagaaccc acactgcacc agccaagagc acaagtgcaa     9180

tgcctcgtca cagttcctgt gcagcagtgg gcgctgtgtg gctgaggcac tgctctgcaa     9240

cggccaggat gactgtggcg acagctcgga cgagcgtggc tgccacatca atgagtgtct     9300

cagccgcaag ctcagtggct gcagccagga ctgtgaggac ctcaagatcg gcttcaagtg     9360

ccgctgtcgc cctggcttcc ggctgaagga cgacggccgg acgtgtgctg atgtggacga     9420

gtgcagcacc accttcccct gcagccagcg ctgcatcaac actcatggca gctataagtg     9480

tctgtgtgtg gagggctatg caccccgcgg cggcgacccc cacagctgca aggctgtgac     9540

tgacgaggaa ccgtttctga tcttcgccaa ccggtactac ctgcgcaagc tcaacctgga     9600

cgggtccaac tacacgttac ttaagcaggg cctgaacaac gccgttgcct tggattttga     9660

ctaccgagag cagatgatct actggacaga tgtgaccacc cagggcagca tgatccgaag     9720

gatgcacctt aacgggagca atgtgcaggt cctacaccgt acaggcctca gcaaccccga     9780

tgggctggct gtggactggg tgggtggcaa cctgtactgg tgcgacaaag gccgggacac     9840

catcgaggtg tccaagctca atggggccta tcggacggtg ctggtcagct ctggcctccg     9900

tgagcccagg gctctggtgg tggatgtgca gaatgggtac ctgtactgga cagactgggg     9960

tgaccattca ctgatcggcc gcatcggcat ggatgggtcc agccgcagcg tcatcgtgga    10020

caccaagatc acatggccca atggcctgac gctggactat gtcactgagc gcatctactg    10080

ggccgacgcc cgcgaggact acattgaatt tgccagcctg gatggctcca atcgccacgt    10140

tgtgctgagc caggacatcc cgcacatctt tgcactgacc ctgtttgagg actacgtcta    10200

ctggaccgac tgggaaacaa agtccattaa ccgagcccac aagaccacgg gcaccaacaa    10260

aacgctcctc atcagcacgc tgcaccggcc catggacctg catgtcttcc atgccctgcg    10320

ccagccagac gtgcccaatc acccctgcaa ggtcaacaat ggtggctgca gcaacctgtg    10380

cctgctgtcc cccgggggag ggcacaaatg tgcctgcccc accaacttct acctgggcag    10440

cgatgggcgc acctgtgtgt ccaactgcac ggctagccag tttgtatgca agaacgacaa    10500

gtgcatcccc ttctggtgga agtgtgacac cgaggacgac tgcggggacc actcagacga    10560

gcccccggac tgccctgagt tcaagtgccg gcccggacag ttccagtgct ccacaggtat    10620

ctgcacaaac cctgccttca tctgcgatgg cgacaatgac tgccaggaca acagtgacga    10680

ggccaactgt gacatccacg tctgcttgcc cagtcagttc aaatgcacca acaccaaccg    10740

ctgtattccc ggcatcttcc gctgcaatgg gcaggacaac tgcggagatg gggaggatga    10800

gagggactgc cccgaggtga cctgcgcccc caaccagttc cagtgctcca ttaccaaacg    10860

gtgcatcccc cgggtctggg tctgcgaccg ggacaatgac tgtgtggatg gcagtgatga    10920

gcccgccaac tgcacccaga tgacctgtgg tgtggacgag ttccgctgca aggattcggg    10980

ccgctgcatc ccagcgcgtt ggaagtgtga cggagaggat gactgtgggg atggctcgga    11040

tgagcccaag gaagagtgtg atgaacgcac ctgtgagcca taccagttcc gctgcaagaa    11100

caaccgctgc gtgcccggcc gctggcagtg cgactacgac aacgattgcg gtgacaactc    11160

cgatgaagag agctgcaccc ctcggccctg ctccgagagt gagttctcct gtgccaacgg    11220

ccgctgcatc gcggggcgct ggaaatgcga tggagaccac gactgcgcgg acggctcgga    11280

cgagaaagac tgcacccccc gctgtgacat ggaccagttc cagtgcaaga gcggccactg    11340

catccccctg cgctggcgct gtgacgcaga cgccgactgc atggacggca gcgacgagga    11400

ggcctgcggc actggcgtgc ggacctgccc cctggacgag ttccagtgca acaacacctt    11460

gtgcaagccg ctggcctgga agtgcgatgg cgaggatgac tgtggggaca actcagatga    11520

gaaccccgag gagtgtgccc ggttcgtgtg ccctcccaac cggcccttcc gttgcaagaa    11580

tgaccgcgtc tgtctgtgga tcgggcgcca atgcgatggc acggacaact gtggggatgg    11640

gactgatgaa gaggactgtg agccccccac agcccacacc acccactgca aagacaagaa    11700

ggagtttctg tgccggaacc agcgctgcct ctcctcctcc ctgcgctgca acatgttcga    11760

tgactgcggg gacggctctg acgaggagga ctgcagcatc gaccccaagc tgaccagctg    11820

cgccaccaat gccagcatct gtggggacga ggcacgctgc gtgcgcaccg agaaagcggc    11880

ctactgtgcc tgccgctcgg gcttccacac cgtgcccggc cagcccggat gccaagacat    11940

caacgagtgc ctgcgcttcg gcacctgctc ccagctctgc aacaacacca agggcggcca    12000

cctctgcagc tgcgctcgga acttcatgaa gacgcacaac acctgcaagg ccgaaggctc    12060

tgagtaccag gtcctgtaca tcgctgatga caatgagatc cgcagcctgt tccccggcca    12120

cccccattcg gcttacgagc aggcattcca gggtgacgag agtgtccgca ttgatgctat    12180

ggatgtccat gtcaaggctg gccgtgtcta ttggaccaac tggcacacgg gcaccatctc    12240

ctaccgcagc ctgccacctg ctgcgcctcc taccacttcc aaccgccacc ggcgacagat    12300

tgaccggggt gtcacccacc tcaacatttc agggctgaag atgcccagag gcatcgccat    12360

cgactgggtg gccggaaacg tgtactggac cgactcgggc cgagatgtga ttgaggtggc    12420

gcagatgaag ggcgagaacc gcaagacgct catctcgggc atgattgacg agccccacgc    12480

cattgtggtg gacccactga gggggaccat gtactggtca gactggggca accaccccaa    12540

gattgagacg gcagcgatgg atgggacgct tcgggagaca ctggtgcagg acaacattca    12600

gtggcccaca ggcctggccg tggattatca caatgagcgg ctgtactggg cagacgccaa    12660

gctttcagtc atcggcagca tccggctcaa tggcacggac cccattgtgg ctgctgacag    12720

caaacgaggc ctaagtcacc ccttcagcat cgacgtcttt gaggattaca tctatggtgt    12780

cacctacatc aataatcgtg tcttcaagat ccataagttt ggccacagcc ccttggtcaa    12840

cctgacaggg ggcctgagcc acgcctctga cgtggtcctt taccatcagc acaagcagcc    12900

cgaagtgacc aacccatgtg accgcaagaa atgcgagtgg ctctgcctgc tgagccccag    12960

tgggcctgtc tgcacctgtc ccaatgggaa gcggctggac aacggcacat gcgtgcctgt    13020

gccctctcca acgccccccc cagatgctcc ccggcctgga acctgtaacc tgcagtgctt    13080

caacggtggc agctgtttcc tcaatgcacg gaggcagccc aagtgccgct gccaaccccg    13140

ctacacgggt gacaagtgtg aactggacca gtgctgggag cactgtcgca atgggggcac    13200

ctgtgctgcc tccccctctg gcatgcccac gtgccggtgc cccacgggct tcacgggccc    13260

caaatgcacc cagcaggtgt gtgcgggcta ctgtgccaac aacagcacct gcactgtcaa    13320

ccagggcaac cagccccagt gccgatgcct acccggcttc ctgggcgacc gctgccagta    13380

ccggcagtgc tctggctact gtgagaactt tggcacatgc cagatggctg ctgatggctc    13440

ccgacaatgc cgctgcactg cctactttga gggatcgagg tgtgaggtga acaagtgcag    13500

ccgctgtctc gaaggggcct gtgtggtcaa caagcagagt ggggatgtca cctgcaactg    13560

cacggatggc cgggtggccc ccagctgtct gacctgcgtc ggccactgca gcaatggcgg    13620

ctcctgtacc atgaacagca aaatgatgcc tgagtgccag tgcccacccc acatgacagg    13680

gccccggtgt gaggagcacg tcttcagcca gcagcagcca ggacatatag cctccatcct    13740

aatccctctg ctgttgctgc tgctgctggt tctggtggcc ggagtggtat tctggtataa    13800

gcggcgagtc caaggggcta agggcttcca gcaccaacgg atgaccaacg gggccatgaa    13860

cgtggagatt ggaaacccca cctacaagat gtacgaaggc ggagagcctg atgatgtggg    13920

aggcctactg gacgctgact ttgccctgga ccctgacaag cccaccaact tcaccaaccc    13980

cgtgtatgcc acactctaca tggggggcca tggcagtcgc cactccctgg ccagcacgga    14040

cgagaagcga gaactcctgg gccggggccc tgaggacgag ataggggacc ccttggcata    14100

gggccctgcc ccgtcggact gcccccagaa agcctcctgc cccctgccgg tgaagtcctt    14160

cagtgagccc ctccccagcc agcccttccc tggccccgcc ggatgtataa atgtaaaaat    14220

gaaggaatta cattttatat gtgagcgagc aagccggcaa gcgagcacag tattatttct    14280

ccatcccctc cctgcctgct ccttggcacc cccatgctgc cttcagggag acaggcaggg    14340

agggcttggg gctgcacctc ctaccctccc accagaacgc accccactgg gagagctggt    14400

ggtgcagcct tcccctccct gtataagaca ctttgccaag gctctcccct ctcgccccat    14460

ccctgcttgc ccgctcccac agcttcctga gggctaattc tgggaaggga gagttctttg    14520

ctgcccctgt ctggaagacg tggctctggg tgaggtaggc gggaaaggat ggagtgtttt    14580

agttcttggg ggaggccacc ccaaacccca gccccaactc caggggcacc tatgagatgg    14640

ccatgctcaa cccccctccc agacaggccc tccctgtctc cagggccccc accgaggttc    14700

ccagggctgg agacttcctc tggtaaacat tcctccagcc tcccctcccc tggggacgcc    14760

aaggaggtgg gccacaccca ggaagggaaa gcgggcagcc ccgttttggg gacgtgaacg    14820

ttttaataat ttttgctgaa ttcctttaca actaaataac acagatattg ttataaataa    14880

aattgtaaaa aaaaaaaaaa aaaaa                                          14905


<210>  745
<211>  4544
<212>  PRT
<213>  Homo Sapiens

<400>  745

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Gln  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  746
<211>  2831
<212>  DNA
<213>  Homo Sapiens

<400>  746
gcgcgcccgg gtagccaaga gggaggagcg cggggagcgc cgacagccgc ccgcccgccc       60

gcccccgcga cgcccgcgcg caacagttcc cccaaagttg cagcccggga ggcgagcgcg      120

cacgggcggc cgaggggcgg gcggttggcg gggacgcggc ctcgcggccc agagcggaga      180

gtcccggcgg gcggcggcgg catgggcacc cggcagacca agggcagcct ggcggagaga      240

gccagccccg gcgccgcgcc gggcccccga cgcgaacggc cggacttctg ggcgtcgctg      300

ctgctgcgcg ccggggacaa ggcggggcgc gcgggcgcgg ggatgccccc ctaccaccgg      360

cgagtcggca tggtccagga gctgctgcgg atggtgcgcc agggccggcg ggaggaggcg      420

gggacgctgc tgcagcacct gcgccaggac ctgggcatgg agtcgacctc gctagacgac      480

gttctgtatc gctacgccag cttccggaac ctggtggacc ccatcacaca cgacctcatc      540

atcagcctgg cacgctacat ccactgtccc aagccggaag gcgatgcact gggcgccatg      600

gagaagctgt gccggcagct gacataccac ctcagccccc actcccagtg gaggcggcac      660

cgggggctgg tgaaaaggaa gccacaggcc tgcctcaagg ctgtcctggc cggaagcccc      720

ccagacaaca cagtggacct gtcgggaatc ccactgacct cccgagacct ggagcgggtg      780

accagctacc tacagcgctg tggggagcag gtagacagcg tggagctggg cttcacaggc      840

ctcacggacg acatggtcct gcagctgctg ccagcactca gcaccctgcc ccgcctcacc      900

acactggcac tcaatggcaa ccggttgacc cgggccgtgc tgcgcgacct cactgacatc      960

cttaaggatc ccagcaagtt ccccaatgtc acgtggattg acctgggcaa caacgtggac     1020

atcttctcct tgccccagcc cttcctgctc agcctgcgca agcgctcccc aaagcagggc     1080

cacctaccca ccatcctgga gctgggtgag ggcccaggca gtggggagga ggtccgggaa     1140

gggacagtag gccaggagga ccctggaggg ggccctgtgg cacctgccga agaccaccat     1200

gagggcaagg agactgtagc tgcagctcag acgtgacatg gaagtgaagg gcctcaccag     1260

ggagtccttg ttgggtagaa tgggcaaggc aggcagggga gggcgcttct cctatcaggt     1320

gggttaagga tattgccaaa aattggcctg ggccacccac ctacagaaag gcaaaccata     1380

tcatctgggg aaggggattt gtgttaaaac ttcccgttgg tcctctgcat ctgcccccta     1440

tcccattatc tgccatttgg ttcttaagtc atcccaggcc ccagagaacc ctctcagctc     1500

agctcatggc cttccccaaa gacttgtgga aatgggcaca tggctggagg tactgtaagc     1560

ctgagccatt gtgaacacca agagctttcc cccagaaaaa gaatacagta gggcccctac     1620

atgtactgca ttacattttt catttagggg aacaagctcc aaccagagga atgtgtcccc     1680

actcaaggaa ggtgggaatc tttagcaaaa ttcctgtaac tcctggttgc ccgagacccc     1740

agttccatct atgctagggg tggactgaac gtggcctacc tccttatgga gacccagccc     1800

tatttctgag gcccaccttg attctaggca tctgcccata ggaccagcta tcgctatatc     1860

ctttgacaga gcagcctacg atgccatgtg gtagtgctca ggacagacat ggtgcccatg     1920

catacaggca taaagtcctg ttcagaaatc ccctatccac cttccctacc cactgctggc     1980

tgaaaaacta ccagacttct atgtgggctc tgatgtcctt agcatgcagg gtaagtgaca     2040

aacctggctt ccttcttgtc acttgccagt atgacttcac tgacctagac aggccgtaag     2100

aactctttcc ccataactct taagtaatcc accaacacat tccagaaaac cgactgcaga     2160

aggtgggctt taaaacctta aaaacctagg acaatgaagg agtccaatcc cttggcagat     2220

ccaacaagat ggctggggag agggagaaac aaactggagg ctcccaaagg aacctaactt     2280

agcaaaggtt ctcatcttat accctcccct tacccaaata ctgtcctact gaaagggccc     2340

taccagttaa gggatctctt ctaaataaca ggcaacccct agatccaagt agttcagtcc     2400

aggaagactg ggagccaatc actcttgaac cttgtgggca aacagtatgg gggaggaccc     2460

tcttgacagg ccttggtagg caagattcca acacaggaag acagcaagat ggggcctaga     2520

gtatggggcc ctacatgctg ttaaggttgt ggttaggaat ggtgcaatgc tgcaggagct     2580

ggaacaaagc tacaccaagg aacagagcac agagcagcag gggccgaaat tgaggaggcc     2640

ttaaatgctt tgagcttttg ccttcagtct aaagctgtag aatagggggt taagagctta     2700

ggctgaccac agggaagttt acaagctaga gcgaatatct ggactgctaa tatctgacaa     2760

cagtaggcga aatttacttt ttcttcaaat acacattttc aagaattgac acccaagaca     2820

aaaaaaaaaa a                                                          2831


<210>  747
<211>  344
<212>  PRT
<213>  Homo Sapiens

<400>  747

Met Gly Thr Arg Gln Thr Lys Gly Ser Leu Ala Glu Arg Ala Ser Pro 
1               5                   10                  15      


Gly Ala Ala Pro Gly Pro Arg Arg Glu Arg Pro Asp Phe Trp Ala Ser 
            20                  25                  30          


Leu Leu Leu Arg Ala Gly Asp Lys Ala Gly Arg Ala Gly Ala Gly Met 
        35                  40                  45              


Pro Pro Tyr His Arg Arg Val Gly Met Val Gln Glu Leu Leu Arg Met 
    50                  55                  60                  


Val Arg Gln Gly Arg Arg Glu Glu Ala Gly Thr Leu Leu Gln His Leu 
65                  70                  75                  80  


Arg Gln Asp Leu Gly Met Glu Ser Thr Ser Leu Asp Asp Val Leu Tyr 
                85                  90                  95      


Arg Tyr Ala Ser Phe Arg Asn Leu Val Asp Pro Ile Thr His Asp Leu 
            100                 105                 110         


Ile Ile Ser Leu Ala Arg Tyr Ile His Cys Pro Lys Pro Glu Gly Asp 
        115                 120                 125             


Ala Leu Gly Ala Met Glu Lys Leu Cys Arg Gln Leu Thr Tyr His Leu 
    130                 135                 140                 


Ser Pro His Ser Gln Trp Arg Arg His Arg Gly Leu Val Lys Arg Lys 
145                 150                 155                 160 


Pro Gln Ala Cys Leu Lys Ala Val Leu Ala Gly Ser Pro Pro Asp Asn 
                165                 170                 175     


Thr Val Asp Leu Ser Gly Ile Pro Leu Thr Ser Arg Asp Leu Glu Arg 
            180                 185                 190         


Val Thr Ser Tyr Leu Gln Arg Cys Gly Glu Gln Val Asp Ser Val Glu 
        195                 200                 205             


Leu Gly Phe Thr Gly Leu Thr Asp Asp Met Val Leu Gln Leu Leu Pro 
    210                 215                 220                 


Ala Leu Ser Thr Leu Pro Arg Leu Thr Thr Leu Ala Leu Asn Gly Asn 
225                 230                 235                 240 


Arg Leu Thr Arg Ala Val Leu Arg Asp Leu Thr Asp Ile Leu Lys Asp 
                245                 250                 255     


Pro Ser Lys Phe Pro Asn Val Thr Trp Ile Asp Leu Gly Asn Asn Val 
            260                 265                 270         


Asp Ile Phe Ser Leu Pro Gln Pro Phe Leu Leu Ser Leu Arg Lys Arg 
        275                 280                 285             


Ser Pro Lys Gln Gly His Leu Pro Thr Ile Leu Glu Leu Gly Glu Gly 
    290                 295                 300                 


Pro Gly Ser Gly Glu Glu Val Arg Glu Gly Thr Val Gly Gln Glu Asp 
305                 310                 315                 320 


Pro Gly Gly Gly Pro Val Ala Pro Ala Glu Asp His His Glu Gly Lys 
                325                 330                 335     


Glu Thr Val Ala Ala Ala Gln Thr 
            340                 


<210>  748
<211>  875
<212>  DNA
<213>  Homo Sapiens

<400>  748
agccaggcca gcagccctag cttctggaag gatccttcag gctccagaca cccaacctac       60

ccgtggccgg atgtctgcct gagccccacc ccgaatgcca gcccttcttc cctgagctca      120

cccagcccca gctccaggac tgagagcccc aggaagcttg gagagagccc ggcatgtggg      180

gctacctgtc gctgatgcct gtcttcctag ctgtctgggc tatctctggc gtctggatcg      240

tttttgccat tgcagtgacc aacaggactg tggacctcag taaaggcttt ccctacatca      300

gcatctgcgg atccttcccc cctcagagct gcatcttcag ccaggtgctc aatatgggag      360

ctgctctggc cgcgtggatc tgcattgtcc gttaccacca gctccgggac tggggcgtca      420

gaaggtggcc taaccagctg atcctatgga cgggtcttct gtgtgccctg ggcacctccg      480

tggtaggcaa tttccaggaa aagaaccagc ggcctacgca cttggcaggg gccttccttg      540

ccttcatctt gggtaacgtc tacttctggc tgcagctcct cctgtggagg ctgaagaggc      600

tgccccagcc cggggctgcc tggattgggc ccctccgcct gggcctctgc agcgtctgca      660

ccatcctcat tgtggccatg atcgtcctcc acgcctgctc gctgcgtagc gtctctgcgg      720

cctgcgagtg ggtcgtggcc atgctgctgt tcgcgctctt cggtctctta gccgttgact      780

tctccgccct ggagagctgc accctgtgtg ttcagccgtg gcccagcctc agccccccgc      840

cggcctcccc catctccctg ccggtccagc tgtag                                 875


<210>  749
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  749

Met Trp Gly Tyr Leu Ser Leu Met Pro Val Phe Leu Ala Val Trp Ala 
1               5                   10                  15      


Ile Ser Gly Val Trp Ile Val Phe Ala Ile Ala Val Thr Asn Arg Thr 
            20                  25                  30          


Val Asp Leu Ser Lys Gly Phe Pro Tyr Ile Ser Ile Cys Gly Ser Phe 
        35                  40                  45              


Pro Pro Gln Ser Cys Ile Phe Ser Gln Val Leu Asn Met Gly Ala Ala 
    50                  55                  60                  


Leu Ala Ala Trp Ile Cys Ile Val Arg Tyr His Gln Leu Arg Asp Trp 
65                  70                  75                  80  


Gly Val Arg Arg Trp Pro Asn Gln Leu Ile Leu Trp Thr Gly Leu Leu 
                85                  90                  95      


Cys Ala Leu Gly Thr Ser Val Val Gly Asn Phe Gln Glu Lys Asn Gln 
            100                 105                 110         


Arg Pro Thr His Leu Ala Gly Ala Phe Leu Ala Phe Ile Leu Gly Asn 
        115                 120                 125             


Val Tyr Phe Trp Leu Gln Leu Leu Leu Trp Arg Leu Lys Arg Leu Pro 
    130                 135                 140                 


Gln Pro Gly Ala Ala Trp Ile Gly Pro Leu Arg Leu Gly Leu Cys Ser 
145                 150                 155                 160 


Val Cys Thr Ile Leu Ile Val Ala Met Ile Val Leu His Ala Cys Ser 
                165                 170                 175     


Leu Arg Ser Val Ser Ala Ala Cys Glu Trp Val Val Ala Met Leu Leu 
            180                 185                 190         


Phe Ala Leu Phe Gly Leu Leu Ala Val Asp Phe Ser Ala Leu Glu Ser 
        195                 200                 205             


Cys Thr Leu Cys Val Gln Pro Trp Pro Ser Leu Ser Pro Pro Pro Ala 
    210                 215                 220                 


Ser Pro Ile Ser Leu Pro Val Gln Leu 
225                 230             


<210>  750
<211>  2807
<212>  DNA
<213>  Homo Sapiens

<400>  750
gagctgacac ctccttagcg ctggccgcgg gccgcctctg cggcagcgct agtcgccttc       60

tccgaatcgg ctccgcacag ctaggagaaa agatgttcac tgtgctgacc cgccaaccat      120

gtgagcaagc aggcctcaag gccctctacc gaactccaac catcattgcc ttggtggtct      180

tgcttgtgag tattgtggta cttgtgagta tcactgtcat ccagatccac aagcaagagg      240

tcctccctcc aggactgaag tatggtattg tgctggatgc cgggtcttca agaaccacag      300

tctacgtgta tcaatggcca gcagaaaaag agaataatac cggagtggtc agtcaaacct      360

tcaaatgtag tgtgaaaggc tctggaatct ccagctatgg aaataacccc caagatgtcc      420

ccagagcctt tgaggagtgt atgcaaaaag tcaaggggca ggttccatcc cacctccacg      480

gatccacccc cattcacctg ggagccacgg ctgggatgcg cttgctgagg ttgcaaaatg      540

aaacagcagc taatgaagtc cttgaaagca tccaaagcta cttcaagtcc cagccctttg      600

actttagggg tgctcaaatc atttctgggc aagaagaagg ggtatatgga tggattacag      660

ccaactattt aatgggaaat ttcctggaga agaacctgtg gcacatgtgg gtgcacccgc      720

atggagtgga aaccacgggt gccctggact taggtggtgc ctccacccaa atatccttcg      780

tggcaggaga gaagatggat ctgaacacca gcgacatcat gcaggtgtcc ctgtatggct      840

acgtatacac gctctacaca cacagcttcc agtgctatgg ccggaatgag gctgagaaga      900

agtttctggc aatgctcctg cagaattctc ctaccaaaaa ccatctcacc aatccctgtt      960

accctcggga ttatagcatc agcttcacca tgggccatgt atttgatagc ctgtgcactg     1020

tggaccagag gccagaaagt tataacccca atgatgtcat cacttttgaa ggaactgggg     1080

acccatctct gtgtaaggag aaggtggctt ccatatttga cttcaaagct tgccatgatc     1140

aagaaacctg ttcttttgat ggggtttatc agccaaagat taaagggcca tttgtggctt     1200

ttgcaggatt ctactacaca gccagtgctt taaatctttc aggtagcttt tccctggaca     1260

ccttcaactc cagcacctgg aatttctgct cacagaattg gagtcagctc ccactgctgc     1320

tccccaaatt tgatgaggta tatgcccgct cttactgctt ctcagccaac tacatctacc     1380

acttgtttgt gaacggttac aaattcacag aggagacttg gccccaaata cactttgaaa     1440

aagaagtggg gaatagcagc atagcctggt ctcttggcta catgctcagc ctgaccaacc     1500

agatcccagc tgaaagccct ctgatccgtc tgcccataga accacctgtc tttgtgggca     1560

ccctcgcttt cttcacagcg gcagccttgc tgtgtctggc atttcttgca tacctgtgtt     1620

cagcaaccag aagaaagagg cactccgagc atgcctttga ccatgcagtg gattctgact     1680

gagccttcaa agcagctcct ggagtccaat ggctgcttag agtcagcctg ggtggcacca     1740

ggcaatgcag gtgaagtggc tgccttcagg aaatacaact aactaaaatc aaacacctag     1800

gtcacgtgcc tctcaaatac tgatttctgc cacagcacct cttgaggcat cccttggcta     1860

ttctgtgcat attgttcttc agagacctca ctacccacat gctgatctat tggggaacag     1920

agaagagaca ggccacgaag gtcaggctct ttatattaag ttccccagag gaagagtaag     1980

ttgagaaggt atcagtttaa tgttgaagaa ttgacctcag ggctcagttt ccatttccct     2040

ccctcagtat tcttcctggc aagataccca ttaagcattt cgccaatcag aatctcattt     2100

tatagttttt cccattggtc tttaactaag actttcttgt agcaatctcg taagcagtga     2160

accccctcag atcagtagaa tatagtatct gggggagaag acttacttcc ttcagggcag     2220

cagccacagc caggcttctg tcatacaggt agatcccgaa gcacagagac ataaaaaagg     2280

tctcccagaa aactatagac cattctccaa gtggaattcc cacttagggc tctggtcact     2340

agattgcaac ctgtgtgttt gtcatcatcc tcatctcacc attgtattgc tatgccctcc     2400

cataaaaaca cattgatccc tagcaagatt attgcattcc agattttact gcctttgcta     2460

ggcttttgct tagcaaaggg ctgactttcc attgttatca tggtgtatat atttttgtca     2520

ccattcccac aagtatactt gatgttgtca tagaacgaac atcctactct atgatttact     2580

aaccaattac tttcccagat catagacctc tctgcatagt agtcataggt cttgactttg     2640

gggaaagaaa aggaagctgc aggaatattt atctccaaag tcgaatgaga aagaactcca     2700

gcaaatccaa tggctacaaa ctaaaaatca gcattatttc atattgctgt ttcttagctg     2760

aatatggaat aaagaactat tattttattt tgaaaaaaaa aaaaaaa                   2807


<210>  751
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  751

Met Phe Thr Val Leu Thr Arg Gln Pro Cys Glu Gln Ala Gly Leu Lys 
1               5                   10                  15      


Ala Leu Tyr Arg Thr Pro Thr Ile Ile Ala Leu Val Val Leu Leu Val 
            20                  25                  30          


Ser Ile Val Val Leu Val Ser Ile Thr Val Ile Gln Ile His Lys Gln 
        35                  40                  45              


Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly 
    50                  55                  60                  


Ser Ser Arg Thr Thr Val Tyr Val Tyr Gln Trp Pro Ala Glu Lys Glu 
65                  70                  75                  80  


Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys Cys Ser Val Lys Gly 
                85                  90                  95      


Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln Asp Val Pro Arg Ala 
            100                 105                 110         


Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln Val Pro Ser His Leu 
        115                 120                 125             


His Gly Ser Thr Pro Ile His Leu Gly Ala Thr Ala Gly Met Arg Leu 
    130                 135                 140                 


Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu Val Leu Glu Ser Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe Arg Gly Ala Gln Ile 
                165                 170                 175     


Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp Ile Thr Ala Asn Tyr 
            180                 185                 190         


Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp His Met Trp Val His 
        195                 200                 205             


Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp Leu Gly Gly Ala Ser 
    210                 215                 220                 


Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met Asp Leu Asn Thr Ser 
225                 230                 235                 240 


Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val Tyr Thr Leu Tyr Thr 
                245                 250                 255     


His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala Glu Lys Lys Phe Leu 
            260                 265                 270         


Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn His Leu Thr Asn Pro 
        275                 280                 285             


Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr Met Gly His Val Phe 
    290                 295                 300                 


Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu Ser Tyr Asn Pro Asn 
305                 310                 315                 320 


Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro Ser Leu Cys Lys Glu 
                325                 330                 335     


Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys His Asp Gln Glu Thr 
            340                 345                 350         


Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile Lys Gly Pro Phe Val 
        355                 360                 365             


Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala Leu Asn Leu Ser Gly 
    370                 375                 380                 


Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr Trp Asn Phe Cys Ser 
385                 390                 395                 400 


Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro Lys Phe Asp Glu Val 
                405                 410                 415     


Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr Ile Tyr His Leu Phe 
            420                 425                 430         


Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp Pro Gln Ile His Phe 
        435                 440                 445             


Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp Ser Leu Gly Tyr Met 
    450                 455                 460                 


Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser Pro Leu Ile Arg Leu 
465                 470                 475                 480 


Pro Ile Glu Pro Pro Val Phe Val Gly Thr Leu Ala Phe Phe Thr Ala 
                485                 490                 495     


Ala Ala Leu Leu Cys Leu Ala Phe Leu Ala Tyr Leu Cys Ser Ala Thr 
            500                 505                 510         


Arg Arg Lys Arg His Ser Glu His Ala Phe Asp His Ala Val Asp Ser 
        515                 520                 525             


Asp 
    


<210>  752
<211>  6019
<212>  DNA
<213>  Homo Sapiens

<400>  752
aggcgggcca cgagagggcg cagcgcggcg cggcagggat tcgcgggcga ccacccggcg       60

caggagcggc cgcgtttcgg cctcagaatc cattgaagac ttgaacaagt gggccctatt      120

tcttgtgtct ccttttatac ttgaagcaga acacatagca tttgtgacgg agagcatttg      180

ggtacaaagt gagaatttac agagatcatc ctcttcagaa acagttcggt ttttgcccac      240

tagggatgat gtggtttctc atgaggttac ttgctctaaa ggactttata ttttggaacc      300

ataagagcac ccttgtggcc caggcacttt atggatgatc ccttttagtg ctcccagtaa      360

ccttccaaga ttgtcaagtg gtcagactgt tgtttgccat tagcttgcag acctggggat      420

ccttatcggc taattgctga agcaagtgtg gacaacttca gcaagctggg ggtggcgttc      480

atggaagata gactccacat ggataatgga ctggtacccc aaaagattgt gtcggtgcac      540

ttgcaggact ccactctgaa ggaagttaag gatcaggtct caaacaagca agcccagatc      600

ctagagccga agcctgaacc ttctcttgag attaagcctg agcaggacgg tatggagcat      660

gttggcagag atgacccaaa ggctcttggt gaagaaccca aacaaaggag aggcagtgcc      720

tctgggagtg agcctgctgg ggacagtgac aggggagggg gccccgttga gcattatcac      780

ctccatctgt ctagttgcca cgagtgtctg gaacttgaga acagcaccat tgagtcagtc      840

aagtttgcgt ctgccgagaa cattccagac cttccctacg attatagcag cagtttggag      900

agtgttgctg atgagacctc ccccgaaaga gaagggagga gagtcaacct cacgggaaag      960

gcacccaaca tcctcctcta tgtgggctcc gactcccagg aagccctcgg ccggttccac     1020

gaggtccggt ctgtgctggc cgactgtgtg gacattgaca gttatattct ctaccacctg     1080

ctggaggaca gtgctctcag agacccgtgg acggacaact gtctgctgtt ggtcattgct     1140

accagggagt ccattcccga agacctgtac cagaagttca tggcctatct ttctcaggga     1200

gggaaggtgt tgggcctgtc ttcatccttc acctttggtg gctttcaggt gacaagcaag     1260

ggtgcactgc acaagacagt ccagaacttg gttttctcca aggctgacca gagcgaggtg     1320

aagctcagcg tcttgagcag tggctgcagg taccaggaag gccccgtccg gctcagcccc     1380

ggcaggctcc agggccacct ggagaatgag gacaaggaca ggatgattgt gcatgtgcct     1440

tttggaactc gcgggggaga agctgttctt tgccaggtgc acttagaact acctcccagc     1500

tccaacatag tgcaaactcc agaagatttt aacttgctca agtcaagcaa ttttagaaga     1560

tacgaagtcc ttagagagat tctgacaacc cttggcctca gctgtgacat gaaacaagtt     1620

cctgccttaa ctcctcttta cttgctgtca gctgcggagg aaatcaggga tcctcttatg     1680

cagtggcttg ggaaacatgt ggactccgag ggagaaataa aatccggcca gctctctctt     1740

agatttgttt catcctacgt gtctgaagta gaaataaccc catcttgtat acctgtggtg     1800

accaacatgg aggccttctc atcagaacat ttcaacttag agatctatcg ccaaaatctg     1860

cagaccaagc agttggggaa agtaattttg tttgccgaag tgacccccac aacgatgcgt     1920

ctcctggatg ggctgatgtt tcagacaccg caggaaatgg gcttaatagt gatcgcggcc     1980

cggcagaccg agggcaaagg acggggaggg aatgtgtggc tgagccctgt gggatgtgct     2040

ctttctactc tgctcatctc cattccactg agatcccagc tgggacagag gatcccgttt     2100

gtccagcatc tgatgtccgt ggctgtcgtg gaagcagtga ggtccattcc cgagtatcag     2160

gatatcaact tacgagtgaa gtggcccaac gatatttatt acagtgacct catgaagatc     2220

ggcggagttc tggttaactc aacactcatg ggagaaacat tttatatact tattggctgt     2280

ggatttaatg tgactaacag taaccctacc atctgcatca acgacctcat cacagaatac     2340

aataaacaac acaaggcaga actgaagccc ttaagagccg attatctcat cgccagagtc     2400

gtgactgtgc tggagaaact gatcaaagag tttcaggaca aagggcccaa cagcgtcctt     2460

cccctttatt accgatactg ggtccacagt ggtcagcaag tccatctggg cagcgcagag     2520

ggaccaaagg tgtccatcgt tggcctggac gattctggct tcctccaggt tcaccaggag     2580

ggcggcgagg ttgtgactgt gcacccggac ggcaactcct tcgacatgct gagaaacctc     2640

atcctcccca aacggcggta atgccgggcg tccccgagac gcggctgcct gtccgtgccc     2700

atgcatctgg aaatctaatt tagagttgta ggtgaatttt cttttcctcc aattcatttg     2760

ttaagtcttt gttctttttc tgtgtttctg tttgttttta ggtttgtttt gttgtcgttt     2820

tctttggtgt ttgaagaggc tctgggatag atggttaaga agtagaaaat ttagtttagg     2880

gaaagccctc ccacaggtgg gaaattgctc tcccctctgt ggcttggact tacgtttatt     2940

gtcaagggga gtttttacat ggaaatgaca atgggaaaat tcagatattt tcttagtagt     3000

gcagaccttt acccctagtc tatgaaaaaa caaaccaaaa tatgctcttg cgcccaggcc     3060

agtggtgagt tagaggtatg ctatcactgt ttgtaagcat ctggggaggt actgaactgt     3120

aagaacatgc ttggacactt agtcattgtt ctgtgttttt attaatgaag aaaagggaag     3180

acagacttcc aagagttact gtccacccgg tggtgtggcc ccatagcgaa gtctaaatgc     3240

ctgtagagat agagctagct ggtgtggttg cagtgacctt gtagaggaaa tcagttcatt     3300

actttgacat cattcagtga gctctccttt cctaaggaag tttaaatgtc cttagttagg     3360

gactgacttt cttaagtaag tttaaattta ctacatattg tgaagagaca ggatcaagtt     3420

cagaatcctt aaatgtctga ttaggcatca cttggatgag gaggtgggcg atttggctct     3480

gacagctgga gatgaaggca cactcatacc acatacaagg gaggatttgg agcttttaag     3540

ccagtttcag atttactctg aaatgtggag cattcctgca agactgtgca gctcacggaa     3600

tatagaagac atggcatttt actcagaagt cataagtttt tgcccccctc atttacctcg     3660

tattaccaag aaagaaaatg ttatcgatac taaacaccat cagttcagag ggaggatgtg     3720

tgtgtgtgcc cgcatatgtg tgtgcgtgcg tgtgtgcgca catagcttta aaagaagaca     3780

ttcaaaattt gatgtgctac aagcctcatg aaagaacaaa agaaatgaag ccttttgata     3840

tgcattcgct attcccagat gtacgccatg ccttttccat gtccctccta tctctgttga     3900

acttatgaat catactcatt acttttcagc tttttaaaag gccaattttt gtccagtttt     3960

ctctcttcca gtcccagctg aaattagtgg aaagaaagtt tgatggagct ttcagctttg     4020

aacaaaatcc cttcattgta aactagcacc atctttatcc aggtcttacc cagtcaggct     4080

aattccagaa acttgtggtt tttagtatag tctgtctacc tttagccagg cacaggacag     4140

ccctatgaaa aaatacccaa tatatatttt ttggaaatga aacattaaaa gaacttaaaa     4200

agtaattttt ggaaatgagg cttcaattag aattattttt ctcaaaaaac aaacaaacaa     4260

aaaacacaaa aaaaaccact cttctccaaa tgcccaagcc ttctttcaaa attagttaga     4320

aacttaagta aaatacaagt ccacaccatc cccaaattac aaaatggact tacccttgag     4380

agggcatctg cagaatatca tcagggacaa agatctcgag gctaacgatg taggtttcat     4440

ttctcagact ttgtaatata aggcaagccc tctctcagag ctgccatcat cactttttga     4500

atttctttgg gggttattta atgaaaaaca tgctatgttt tgttttaagc tgaagtccta     4560

ttctggacac tctgctttgg gaaaaaatgt tatcatttaa tttcctttct gcaaattaaa     4620

actaatgaag tgtggccttg tcaaaggcta tggagatgtt ccgggcatac tgctgtgctc     4680

tgtgctttcc agcaggcgct cctccctcac gcaggagact cagttgtcct gagagagatg     4740

aagcagcctt gaagcagatg ctgcgttttc cataaacctg attttgcctc acatgaacca     4800

aagactctca aaactccgct tctatagaat tagctgaata aaggcatttt actgatagct     4860

gttcgtgtta gcgaaacctg tctacctgct atagcacact ctccgatttg ggccatttat     4920

gcaccccgca acctgggatc tcaaggagct ttaaagtctt aatgggaact tggcattttc     4980

ctgatgatct ttaaaatgtg gtcactaaac tcaggattgg cgtgtgcttt tagaacactg     5040

gagtagccct tgttttagag gctgtgcatt gagtatcgac cgtattttgt aaaaggcaag     5100

atatcctccc ttccaggctg gtaacgggtt tcaaggggac tcttgaggaa gtgcccccta     5160

aaatagaaca cagcaataac tgggcttcct gtccccaccc ccaccccagc agtgctctct     5220

ggcactggga actctgctag ggagtggtgg aagtaggaag gatttgtgtg caaaggaaaa     5280

tcgtggttga gtttcactgc agcaggctga cgttgcctga tgtgagagca agtggccgac     5340

tggggtgcgg gtgcacaggt cgggggagca caggccacag agcgcagcct ctgggggtcc     5400

cccaaggcac agcatataca gcatggtcgc cccttgccct ggagtctggg aacaaagaga     5460

ggagccagcc tccccgcact gcttcagatg gaaaagggag gcagggtggg cttccgttct     5520

ccagatctgt ttgctcttaa caggcagaac atgggagaat ccttattcct ggttaatcac     5580

tatgcatatt tgaaataaaa gaaagcgtaa gcctctgcaa ttttaacttc tcaaaggatg     5640

tctctgaaaa gaatcacttt aaaccaatgc ctataaaaag caagtctacc aaaataaact     5700

aagactttct atgtggtttg ggctccctct tatttttaca agtttcattt ttaaaagtag     5760

gcaactactt tgggttacag tatttttatt catatttaaa catttttaca aaataaataa     5820

agtgttttac atagtaagga atatgtacgt atttccaagt attaagaagc caagtgtttt     5880

tttttttgac gtattattga caaatgtatt cagcgccata cacaagagaa atattattac     5940

tccaaagaac gaaagttaac aaaactccaa agcaaaaacc cttttaatgg aggtgagaaa     6000

taaatttaat gtaacaaca                                                  6019


<210>  753
<211>  726
<212>  PRT
<213>  Homo Sapiens

<400>  753

Met Glu Asp Arg Leu His Met Asp Asn Gly Leu Val Pro Gln Lys Ile 
1               5                   10                  15      


Val Ser Val His Leu Gln Asp Ser Thr Leu Lys Glu Val Lys Asp Gln 
            20                  25                  30          


Val Ser Asn Lys Gln Ala Gln Ile Leu Glu Pro Lys Pro Glu Pro Ser 
        35                  40                  45              


Leu Glu Ile Lys Pro Glu Gln Asp Gly Met Glu His Val Gly Arg Asp 
    50                  55                  60                  


Asp Pro Lys Ala Leu Gly Glu Glu Pro Lys Gln Arg Arg Gly Ser Ala 
65                  70                  75                  80  


Ser Gly Ser Glu Pro Ala Gly Asp Ser Asp Arg Gly Gly Gly Pro Val 
                85                  90                  95      


Glu His Tyr His Leu His Leu Ser Ser Cys His Glu Cys Leu Glu Leu 
            100                 105                 110         


Glu Asn Ser Thr Ile Glu Ser Val Lys Phe Ala Ser Ala Glu Asn Ile 
        115                 120                 125             


Pro Asp Leu Pro Tyr Asp Tyr Ser Ser Ser Leu Glu Ser Val Ala Asp 
    130                 135                 140                 


Glu Thr Ser Pro Glu Arg Glu Gly Arg Arg Val Asn Leu Thr Gly Lys 
145                 150                 155                 160 


Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Asp Ser Gln Glu Ala Leu 
                165                 170                 175     


Gly Arg Phe His Glu Val Arg Ser Val Leu Ala Asp Cys Val Asp Ile 
            180                 185                 190         


Asp Ser Tyr Ile Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp 
        195                 200                 205             


Pro Trp Thr Asp Asn Cys Leu Leu Leu Val Ile Ala Thr Arg Glu Ser 
    210                 215                 220                 


Ile Pro Glu Asp Leu Tyr Gln Lys Phe Met Ala Tyr Leu Ser Gln Gly 
225                 230                 235                 240 


Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly Gly Phe Gln 
                245                 250                 255     


Val Thr Ser Lys Gly Ala Leu His Lys Thr Val Gln Asn Leu Val Phe 
            260                 265                 270         


Ser Lys Ala Asp Gln Ser Glu Val Lys Leu Ser Val Leu Ser Ser Gly 
        275                 280                 285             


Cys Arg Tyr Gln Glu Gly Pro Val Arg Leu Ser Pro Gly Arg Leu Gln 
    290                 295                 300                 


Gly His Leu Glu Asn Glu Asp Lys Asp Arg Met Ile Val His Val Pro 
305                 310                 315                 320 


Phe Gly Thr Arg Gly Gly Glu Ala Val Leu Cys Gln Val His Leu Glu 
                325                 330                 335     


Leu Pro Pro Ser Ser Asn Ile Val Gln Thr Pro Glu Asp Phe Asn Leu 
            340                 345                 350         


Leu Lys Ser Ser Asn Phe Arg Arg Tyr Glu Val Leu Arg Glu Ile Leu 
        355                 360                 365             


Thr Thr Leu Gly Leu Ser Cys Asp Met Lys Gln Val Pro Ala Leu Thr 
    370                 375                 380                 


Pro Leu Tyr Leu Leu Ser Ala Ala Glu Glu Ile Arg Asp Pro Leu Met 
385                 390                 395                 400 


Gln Trp Leu Gly Lys His Val Asp Ser Glu Gly Glu Ile Lys Ser Gly 
                405                 410                 415     


Gln Leu Ser Leu Arg Phe Val Ser Ser Tyr Val Ser Glu Val Glu Ile 
            420                 425                 430         


Thr Pro Ser Cys Ile Pro Val Val Thr Asn Met Glu Ala Phe Ser Ser 
        435                 440                 445             


Glu His Phe Asn Leu Glu Ile Tyr Arg Gln Asn Leu Gln Thr Lys Gln 
    450                 455                 460                 


Leu Gly Lys Val Ile Leu Phe Ala Glu Val Thr Pro Thr Thr Met Arg 
465                 470                 475                 480 


Leu Leu Asp Gly Leu Met Phe Gln Thr Pro Gln Glu Met Gly Leu Ile 
                485                 490                 495     


Val Ile Ala Ala Arg Gln Thr Glu Gly Lys Gly Arg Gly Gly Asn Val 
            500                 505                 510         


Trp Leu Ser Pro Val Gly Cys Ala Leu Ser Thr Leu Leu Ile Ser Ile 
        515                 520                 525             


Pro Leu Arg Ser Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu 
    530                 535                 540                 


Met Ser Val Ala Val Val Glu Ala Val Arg Ser Ile Pro Glu Tyr Gln 
545                 550                 555                 560 


Asp Ile Asn Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp 
                565                 570                 575     


Leu Met Lys Ile Gly Gly Val Leu Val Asn Ser Thr Leu Met Gly Glu 
            580                 585                 590         


Thr Phe Tyr Ile Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn 
        595                 600                 605             


Pro Thr Ile Cys Ile Asn Asp Leu Ile Thr Glu Tyr Asn Lys Gln His 
    610                 615                 620                 


Lys Ala Glu Leu Lys Pro Leu Arg Ala Asp Tyr Leu Ile Ala Arg Val 
625                 630                 635                 640 


Val Thr Val Leu Glu Lys Leu Ile Lys Glu Phe Gln Asp Lys Gly Pro 
                645                 650                 655     


Asn Ser Val Leu Pro Leu Tyr Tyr Arg Tyr Trp Val His Ser Gly Gln 
            660                 665                 670         


Gln Val His Leu Gly Ser Ala Glu Gly Pro Lys Val Ser Ile Val Gly 
        675                 680                 685             


Leu Asp Asp Ser Gly Phe Leu Gln Val His Gln Glu Gly Gly Glu Val 
    690                 695                 700                 


Val Thr Val His Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu 
705                 710                 715                 720 


Ile Leu Pro Lys Arg Arg 
                725     


<210>  754
<211>  2689
<212>  DNA
<213>  Homo Sapiens

<400>  754
gacttcctga tttgcaagaa ggtgcaggag ccgcagcggg cggccccggt cgcaggaact       60

gagaggcctc agctttggtg gcggctaccg gcggagacgg gggcggcggc cacgccaccg      120

ctgctgtcac agaaaggctc tggtgggtgg ggtgggaggc ggggaagtgc cgggggcgca      180

gccgacatgg gcccgccgcc acggctgctg tgagcagcct ctttccctgt gtggccgccg      240

gcgtgggcgg ggacggcgcg accctcgcgc ggccgggctg cgggcttcca ggccagcgcg      300

cgggggccgg acggacagcc ccacaccgac atgtaaccat ggactgcagg accaaggcaa      360

atccagacag aacctttgac ttggtgttga aagtgaaatg tcatgcctct gaaaatgaag      420

atcctgtggt attgtggaaa ttcccagagg actttggaga ccaggaaata ctacagagtg      480

tgccaaagtt ctgttttccc tttgacgttg aaagggtgtc tcagaatcaa gttggacagc      540

actttacctt tgtactgaca gacattgaaa gtaaacagag atttggattc tgcagactga      600

cgtcaggagg cacaatttgt ttatgcatcc ttagttacct tccctggttt gaagtgtatt      660

acaagcttct aaatactctt gcagattact tggctaagga actggaaaat gatttgaatg      720

aaactctcag atcactgtat aaccacccag taccaaaggc aaatactcct gtaaatttga      780

gtgtgcattc ctacttcatt gcccctgatg taactggact cccaacaata cccgagagta      840

gaaatcttac agaatatttt gttgccgtgg atgtgaacaa catgctgcag ctgtatgcca      900

gtatgctgca tgaaaggcgc atcgtgatta tctcgagcaa attaagcact ttaactgcct      960

gtatccatgg atcagctgct cttctatacc caatgtattg gcaacacata tacatcccag     1020

tgcttcctcc acacctgctg gactactgct gtgccccaat gccatacctg attggaatac     1080

actccagcct catagagaga gtgaaaaaca aatcattgga agatgttgtt atgttaaatg     1140

ttgatacaaa cacattagaa tcaccattta gtgacttgaa caacctacca agtgatgtgg     1200

tctcggcctt gaaaaataaa ctgaagaagc agtctacagc tacgggtgat ggagtagcta     1260

gggcctttct tagagcacag gctgctttgt ttggatccta cagagatgca ctgagataca     1320

aacctggtga gcccatcact ttctgtgagg agagttttgt aaagcaccgc tcaagcgtga     1380

tgaaacagtt cctggaaact gccattaacc tccagctttt taagcagttt atcgatggtc     1440

gactggcaaa actaaatgca ggaaggggtt tctctgatgt atttgaagaa gagatcactt     1500

caggtggctt ttgtggaggg aacccgaggt catatcaaca atgggtgcat acagtcaaga     1560

aaggaggtgc actgttcaac acagcaatga ccaaagcaac ccctgctgta cggacagcat     1620

ataaatttgc aaaaaatcat gcaaagctgg gactaaagga agtgaagagt aaactaaaac     1680

acaaggaaaa tgaagaagat tatgggacct gttctagttc tgtacaatat acaccagttt     1740

acaaattaca caatgaaaag ggaggaaact cagaaaagcg taagcttgct caggcacgct     1800

taaaaaggcc tcttaagagc cttgatggtg ctctatatga tgatgaagat gatgatgaca     1860

ttgaaagagc aagcaagtta tcttctgaag atggtgaaga agcttctgct tatctctatg     1920

agagtgatga ctctgttgaa acaagagtga agactcctta ctcaggtgaa atggacttac     1980

taggagagat tcttgataca ttgagcacac acagctcaga tcaggggaag ctggcagctg     2040

caaagagctt ggatttcttt agatcaatgg atgacattga ttacaaacct acgaataaat     2100

ctaatgctcc tagtgagaat aacctggctt tcctctgtgg tggttctggt gaccaagcag     2160

agtggaatct tgggcaagac gatagtgccc tccatggcaa acacctccct ccatctccta     2220

ggaagcgggt ttcctctagt ggtttgacag attctctgtt tatcctgaaa gaggaaaaca     2280

gtaacaagca cctcggtgct gacaatgtga gtgaccctac ttcaggactg gatttccaac     2340

tcacttcccc tgaagtttcc cagactgata aaggaaaaac agaaaagagg gaaacactaa     2400

gccagatttc agatgatctg cttatacccg gtcttgggcg gcattcatcg acttttgttc     2460

cttgggagaa agaagggaaa gaagccaaag agacttcaga agatattgga ctgctccatg     2520

aagtagtgtc attatgtcat atgacatctg acttccaaca aagcttgaac atttcagaca     2580

aaaacacaaa tggaaaccaa acttaaatct tgcatccaag cttctatgga gacattttga     2640

gattcaatgc aatctgtata ataaacagaa ttatttgtag gaatggcaa                 2689


<210>  755
<211>  755
<212>  PRT
<213>  Homo Sapiens

<400>  755

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val His Ser Tyr Phe Ile Ala Pro Asp Val Thr Gly 
145                 150                 155                 160 


Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu Tyr Phe Val Ala 
                165                 170                 175     


Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser Met Leu His Glu 
            180                 185                 190         


Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr Leu Thr Ala Cys 
        195                 200                 205             


Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr Trp Gln His Ile 
    210                 215                 220                 


Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys Ala Pro 
225                 230                 235                 240 


Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile Glu Arg Val Lys 
                245                 250                 255     


Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val Asp Thr Asn Thr 
            260                 265                 270         


Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro Ser Asp Val Val 
        275                 280                 285             


Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr Ala Thr Gly Asp 
    290                 295                 300                 


Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala Leu Phe Gly Ser 
305                 310                 315                 320 


Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro Ile Thr Phe Cys 
                325                 330                 335     


Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met Lys Gln Phe Leu 
            340                 345                 350         


Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe Ile Asp Gly Arg 
        355                 360                 365             


Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp Val Phe Glu Glu 
    370                 375                 380                 


Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Asn Pro Arg Ser Tyr Gln 
385                 390                 395                 400 


Gln Trp Val His Thr Val Lys Lys Gly Gly Ala Leu Phe Asn Thr Ala 
                405                 410                 415     


Met Thr Lys Ala Thr Pro Ala Val Arg Thr Ala Tyr Lys Phe Ala Lys 
            420                 425                 430         


Asn His Ala Lys Leu Gly Leu Lys Glu Val Lys Ser Lys Leu Lys His 
        435                 440                 445             


Lys Glu Asn Glu Glu Asp Tyr Gly Thr Cys Ser Ser Ser Val Gln Tyr 
    450                 455                 460                 


Thr Pro Val Tyr Lys Leu His Asn Glu Lys Gly Gly Asn Ser Glu Lys 
465                 470                 475                 480 


Arg Lys Leu Ala Gln Ala Arg Leu Lys Arg Pro Leu Lys Ser Leu Asp 
                485                 490                 495     


Gly Ala Leu Tyr Asp Asp Glu Asp Asp Asp Asp Ile Glu Arg Ala Ser 
            500                 505                 510         


Lys Leu Ser Ser Glu Asp Gly Glu Glu Ala Ser Ala Tyr Leu Tyr Glu 
        515                 520                 525             


Ser Asp Asp Ser Val Glu Thr Arg Val Lys Thr Pro Tyr Ser Gly Glu 
    530                 535                 540                 


Met Asp Leu Leu Gly Glu Ile Leu Asp Thr Leu Ser Thr His Ser Ser 
545                 550                 555                 560 


Asp Gln Gly Lys Leu Ala Ala Ala Lys Ser Leu Asp Phe Phe Arg Ser 
                565                 570                 575     


Met Asp Asp Ile Asp Tyr Lys Pro Thr Asn Lys Ser Asn Ala Pro Ser 
            580                 585                 590         


Glu Asn Asn Leu Ala Phe Leu Cys Gly Gly Ser Gly Asp Gln Ala Glu 
        595                 600                 605             


Trp Asn Leu Gly Gln Asp Asp Ser Ala Leu His Gly Lys His Leu Pro 
    610                 615                 620                 


Pro Ser Pro Arg Lys Arg Val Ser Ser Ser Gly Leu Thr Asp Ser Leu 
625                 630                 635                 640 


Phe Ile Leu Lys Glu Glu Asn Ser Asn Lys His Leu Gly Ala Asp Asn 
                645                 650                 655     


Val Ser Asp Pro Thr Ser Gly Leu Asp Phe Gln Leu Thr Ser Pro Glu 
            660                 665                 670         


Val Ser Gln Thr Asp Lys Gly Lys Thr Glu Lys Arg Glu Thr Leu Ser 
        675                 680                 685             


Gln Ile Ser Asp Asp Leu Leu Ile Pro Gly Leu Gly Arg His Ser Ser 
    690                 695                 700                 


Thr Phe Val Pro Trp Glu Lys Glu Gly Lys Glu Ala Lys Glu Thr Ser 
705                 710                 715                 720 


Glu Asp Ile Gly Leu Leu His Glu Val Val Ser Leu Cys His Met Thr 
                725                 730                 735     


Ser Asp Phe Gln Gln Ser Leu Asn Ile Ser Asp Lys Asn Thr Asn Gly 
            740                 745                 750         


Asn Gln Thr 
        755 


<210>  756
<211>  8662
<212>  DNA
<213>  Homo Sapiens

<400>  756
gtgcacgccg cagtgccggg gactcggcgg ggcgccggcc ggcgggcgga gaccgactcg       60

ggatctgtcc gagcaggaag ccagcctcag cccggccgct gtcgccgccc tgtcctggtg      120

cccgtccgcg tcgtcgccct cttcactggc cctcatcact tctcaccgcg ccctccagct      180

tcacccgtac aggtagcccc gccgccgcgc acctgccttc gctcccgcac cggtgacagt      240

ggatagtgga aacaggagat cgtggatcct ccttcaaaaa tggaggatgg aaagcccgtt      300

tgggcgccac accctacaga tggatttcag atgggcaata ttgtggatat tggccccgac      360

agcttaacaa ttgaaccctt gaatcagaaa ggcaagacat ttttggctct cataaaccaa      420

gtgtttcctg cagaagagga cagtaaaaaa gatgtggaag ataactgttc actaatgtat      480

ttaaatgaag ccacactgct ccataatatc aaagttcgat atagtaaaga cagaatttat      540

acatatgtcg ccaacattct gattgcagtg aatccatact ttgacatacc taaaatatat      600

tcttcagaag caataaagtc atatcaagga aaatctcttg ggacaagacc acctcatgtc      660

tttgcaattg ctgataaagc ttttcgagac atgaaggtgc tcaagatgag tcagtctatc      720

attgtatctg gagaatcagg agccggcaaa acagaaaata caaaatttgt tctaagatac      780

ctgactgaat cctatggaac aggtcaagat attgatgaca gaattgttga agctaaccca      840

ctcctagaag cctttggaaa tgcgaagact gttcgcaaca ataatagcag tcgatttggg      900

aaatttgtag aaatacattt taatgaaaag agctcagttg ttggaggatt tgtttcacat      960

tatctcctag agaaatctag gatctgtgtt caaggcaaag aggaaagaaa ttatcatatc     1020

ttttataggt tgtgtgctgg tgcttctgaa gatattagag aaaaacttca tttgagttca     1080

ccagataatt ttcggtattt aaaccgaggc tgcactagat actttgctaa caaagaaact     1140

gacaaacaga ttttacagaa ccgcaaaagt cctgagtacc ttaaggcagg ttctatgaaa     1200

gatcctctgc tagatgacca tggtgatttt attagaatgt gcacggctat gaaaaaaatt     1260

ggtttggatg atgaagaaaa gcttgatctc ttccgggtag tagctggcgt cctgcacctt     1320

ggaaatattg attttgagga agctggcagc acttcaggtg gttgtaatct gaagaataaa     1380

tctgctcagt ctttggaata ttgtgctgaa ttactgggtt tggaccaaga tgatcttcga     1440

gtaagtttga ccacaagagt catgctaaca acagcagggg gcaccaaagg aacagttata     1500

aaggtacctc tgaaagtgga gcaagcaaac aatgctcgtg atgccctggc aaagacagtg     1560

tatagccatc tttttgatca tgtggtaaac agagtaaatc agtgttttcc ttttgaaaca     1620

tcatcctatt ttattggagt cctagatatt gctggttttg agtactttga gcataacagt     1680

tttgaacaat tttgcatcaa ctattgcaat gaaaaacttc aacaattttt taatgaaagg     1740

attctgaagg aggaacaaga actctatcaa aaagaaggtt taggtgttaa tgaagtgcat     1800

tatgtggata atcaggactg tatagattta attgaagcca aattagtggg aatactggat     1860

attttggatg aagaaaatcg ccttccccag ccaagtgatc aacactttac atctgcagtt     1920

caccaaaagc acaaggatca ttttcgactc actattccca gaaaatctaa gctggcagtt     1980

cataggaata tcagagacga cgaaggcttc attatcaggc attttgcggg ggcagtgtgc     2040

tatgaaacaa cccagtttgt ggagaaaaat aatgatgctt tacatatgtc tcttgaatcc     2100

ttaatatgtg aatccagaga taagtttata cgggaattat ttgaatcatc cacaaataac     2160

aacaaagata ctaaacaaaa agcaggaaaa cttagcttca tcagcgtggg aaacaagttt     2220

aagacacagt taaatttgct tctggataaa cttcgaagta ctggagcaag ctttattcgt     2280

tgcatcaaac ctaacttaaa gatgacaagc caccactttg aaggtgctca aattctgtct     2340

cagcttcagt gttcagggat ggtgtctgtt ttggacttga tgcagggtgg ttacccatca     2400

cgagcttcat ttcatgaact ctacaacatg tacaaaaagt atatgccaga taaacttgca     2460

agattggatc caagactatt ttgtaaggct ttgtttaaag ctttgggctt aaatgaaaat     2520

gactacaagt ttgggttaac caaagtattt tttagacctg gcaagtttgc agaatttgat     2580

cagatcatga agtctgaccc tgaccactta gcagagttgg ttaaaagagt caatcactgg     2640

ctcacatgca gtcgctggaa gaaagttcag tggtgctcac tctcagtcat caaattgaaa     2700

aacaaaataa aatatcgagc tgaagcctgc attaaaatgc aaaaaactat tcgaatgtgg     2760

ctttgcaaga ggagacacaa acctcgcatt gatggtctgg ttaaggtggg cacactgaaa     2820

aaacgacttg ataaatttaa tgaggtagtc agtgtgttga aagatggaaa acccgagatg     2880

aataaacaga tcaagaatct ggaaatttct attgatactt tgatggccaa aattaagtcc     2940

actatgatga cgcaggaaca aatccagaaa gaatatgatg cactggttaa aagctcagag     3000

gaactcctca gtgcattaca gaaaaaaaaa cagcaggaag aggaagcaga aaggctgagg     3060

cgtattcaag aagaaatgga aaaggaaaga aaaagacgtg aagaagacga aaaacgtcga     3120

agaaaggaag aggaggaaag gcggatgaaa cttgagatgg aagcaaagag aaaacaagaa     3180

gaagaagaga gaaagaaaag ggaagatgat gaaaaacgca ttcaagctga agtggaggca     3240

cagctggccc gacagaagga ggaggaatcc caacagcaag cagttctgga gcaggagcgc     3300

agggaccggg agctggccct gaggattgcc cagagtgaag ccgagctcat cagtgatgag     3360

gcccaggccg acctggcgct gcggagaaat gatggaacaa gacccaaaat gacaccggaa     3420

caaatggcca aagaaatgtc agaatttttg agtagaggtc ctgctgtact agccaccaaa     3480

gcagctgctg gtactaagaa atatgatctt agtaaatgga aatatgcaga actacgtgat     3540

accatcaata cttcttgtga tattgagctc ctggcagctt gcagagaaga atttcatagg     3600

agactaaaag tgtatcatgc ttggaaatct aagaacaaga agagaaatac tgaaacagag     3660

caacgtgctc caaagtctgt tactgattat gattttgcac catttttgaa caattcacct     3720

cagcaaaacc cagcagctca gattcctgcc aggcagcggg agattgaaat gaaccgacag     3780

caacgcttct tccgcatccc attcatccgc cctgccgacc agtacaaaga ccctcagagt     3840

aagaaaaaag gctggtggta tgcccatttt gatggaccat ggattgcccg gcaaatggaa     3900

ctccatcctg acaagccacc catcctactt gtggctggta aggacgacat ggagatgtgt     3960

gagctgaatc ttgaggagac tggcctgact cggaagcgtg gtgctgagat cttgccaaga     4020

cagtttgaag aaatctggga acgctgtgga ggcatccagt accttcagaa tgcgattgag     4080

agcagacagg ctcggcccac ctatgcaaca gccatgctgc agagtctgtt aaagtagatg     4140

ttgcacacca gccttacagc tgggagcctt tgccatggta cttaggtagg gtgtgtgccc     4200

ccagatttaa ccattccata atcatgttag agttacttct ataaagtgaa cagattttat     4260

taatcacggc ttttggtgaa tttgtttaag gttaattatg gtagcaaatt ttggacctaa     4320

acattatttt tctgtatccc gctgtaattc ccaaaactct cattattctc taactattac     4380

acatgggcat attctgatgt ttctcatcct ttgccagaag actaccttac atccatcgta     4440

attgttctct aggaaaagag aacttttttc aaaattcaaa atacttttta aggatggcac     4500

agtaccatat aactggagta ataaaacatg agcttacatt cttacaataa ctaaaccact     4560

taaaatgatc aaggcactaa tgttttggtc tgaaaagctg tgtactttat agacattttc     4620

agacattttt ggaaatttcc attaaaggtg gaaaatctat ttttttcctc ctttgcagtg     4680

tcttagtttg aatgaaacac ttcgaagttc tagaattcta gaaagagcct taatgtattt     4740

gatgtattct gtgataagag gtactaatag tatccagcac agatttgctt ttctttgcta     4800

gcacaatgtg tgttgctgtc agaatattct ttttatattc tgtggaaaaa taaaggaaat     4860

tcagattgtt taaatgccta aaagttttga gataagtttt gtttcaatta gaaaaggaaa     4920

taggttttag gtggcatagt ggcttaactg gactgaattc aaatattctt tcaacttcat     4980

ctcaatagtg atttttgtat cagaatcttg tccaagttgt ttcattgatt tagtaagtgt     5040

tctgcttcca acatctttct ttttaagaaa ttcctagtgt cttttttggc ctttgaggtt     5100

ttggtaattg tagacctgtt tcataagctt tgtaattcag aaatccttgt atttagtaag     5160

tgcttgtttt acataactga taattttaaa atgttttctt tgtgtgctgt tagtattgat     5220

tcaaatgtca gcagctttaa gcctaatatt tatgactttc acatttggaa tttaaagaca     5280

aaaatacatc aaggagttat gctgacataa ttctaaggag ttttgttgta ttttagaata     5340

aaattataaa gtaaaatgat tctctgtact gctttttccc ccagttttta gagaccctaa     5400

cctttgaaat gaaattccag tgatttcttt tttccctaga aagattacct cagttaggga     5460

agtatttccc agctgactag tgtttgtgag ccacagacac tgtcttcaga attgcttctc     5520

tcatgtctta gtagagaaat atttatttat tatgatacat tcaaatgatt gtcaagttaa     5580

attaaatggt tgtgtctgtg ctattgagaa tgcaaatgtg attatctttt gaaggctgta     5640

ttactgcata gcttcaccca ccctcgggtc atttcgtccc tgtgattggg gacagaaggt     5700

gtagctactg aagtaaatga cctattctct ctcttccatc tctcgccttt aactggtgtt     5760

tttatttgtg taggatagtg aatgataagc ttttttccta accagtagtg agtaaagttc     5820

ttgaacaaaa tttagtagcc aaattgtttt ttaatgacat gtctctttag tacaatagtt     5880

ttgtgtatct tttagataca ttaataggca ctagatggaa aattaaagag ttaaacatat     5940

ttaaatgaga gaatctaatg tttcagaaat ttgtaagaaa tgtatcacag caaagggttg     6000

ttataagtcc ttagtttttg actctaatag ttaatacaat tatagttaat cttaagccat     6060

aatgtttcta atcatgtcac acagctgtcc tagaacttat ctatttaaaa tagtttcctg     6120

agttaatttt ggccagcagg gcaactgccc taattcagat agatttacag taacctacgt     6180

acagtagatg cacatacaca cagacacccc tttgctggag aaacttagga ccctgtcagc     6240

cttttaaagg aaacagcagg agtggtgtcc taaatgatgt tcatgcagct gctttaccat     6300

gttcacagtc aagcccatgc atgccaggtt aaaactgtgg aaatcaaaag taaattcact     6360

catattttaa tcattttaac tgagatttaa aattagaagt ttaaaccact atatataaag     6420

aactaatctt ttcttaatac cagttctttc catagcatat gctttgcaaa ggcagcatgc     6480

ataaaatatt taaaatgaga ggacagaatg ttttcacatt tgattcaatt ttaatataat     6540

tcctaattgt ggtaacacag ttgagatatg tattatgagt tatgggaact aattgagaaa     6600

aggaagttac tctaatccac gtatgttaag agaatattga gttttcttag ttgtaaagtt     6660

ggggagatgg caccttctca gaggattgtg aaaatatgag gaagaaacaa aacagtgcat     6720

gtaggagcac agggccacac aaaggcattc tattgttatg ctcattctgc ttctgtaatg     6780

acttttcata ggtcattctt gtgaaccatt ttgttttgca agcaaccaag gaaagaacat     6840

cttaagtgga aaatcagtgg tggttgtgaa cacttagaga atagcaatcc acaggcaaga     6900

ataatggtat tgtttgtaga gctttattaa ttggatattt tttaaaagac attttcattc     6960

acaggtcatt actatggttc tcagcgatcc aaatatgtag atcattggtt ttttttttta     7020

cctgaagtag cttaagagta cttggatcag tagaataaat atttattgaa tcaatcagtc     7080

agccaattaa tatgatgtta gtgatagacc tgcctccttt tatggaagag gtaacagatc     7140

cagagaggtc aagtaattta gttgtagact gaaaaatata tcaaagcctt tgctgcaatc     7200

atatgtaaca aaaagaacca aaacaaacac tttttagtgg cacctgtgga tttacaaagg     7260

gttgcctctc tgtcattcca caacttcaga aggtgtgaca ggttttccct atttatcatt     7320

accaataata acaagtattg agagttttaa aatttctccc agaagataaa ctaacaagga     7380

tggaagggga gggcaaagga tatctaaaca tgagaataag gacatgttag agggggggaa     7440

acagttgtaa caataaggaa agagaagagc aacagtggaa gagacaggtt gtgtgcccct     7500

aaagattctg cacccccagt ttggaaacac tgatacattt taggacacag agcactccta     7560

gatctctacg aaattttaga atgaataatg tgtaatttat aggatcagaa cgtatggtta     7620

ttaaaacttg gatcaagata tgcccggtgt atacattctt agcacatagg aatggcactg     7680

ccatactgga gaaggtcagc agtaaatagg cattctgtac ataagcctca tggaagggta     7740

agatggagag actggcagaa gtagcaccta ctctgctggg agcacttctc tgagtacgct     7800

ttagttcaat tcaaatcact gtattctttc cccattgcta acctaatata tgaaacaagc     7860

ttagctgtct cagaagtttt tcaagagatg atcaggaaaa attaatgcac attcaaaagg     7920

agaatcttca gtacaaattt gtttttttaa aaatagattt agggctgggc gcggtggctc     7980

acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg gatcacgagg tcaagacttc     8040

gagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa aacattagcc     8100

aggcgtggta gtgggtgcct gtaatccctg ctacttggga ggctgaggca ggagaatcac     8160

ttgaacgcgg gaggcagagg ttgcagggag ccgagatggc gccattgcac tccatcctgg     8220

gcaacaagag cgaaattcca tctcaaaaaa taaaatagat ttagggggta caagtgcagt     8280

tttgttacat gggtatattg catagtggta aaatgtgggc ttttagtgta cctaacaccc     8340

agagaagcat acattgtgcc cagtaggtaa tttttcatcc ctaaaccttt tctcagcctc     8400

ccactttctg gagtctccaa tgtcggttat tccactcttt atgtccatat ctacacattc     8460

aatcctaatt tgtaccaagt agcatctcac ctttaaatca caggcttatt agttgggtgt     8520

tttcttttta cttatgaaaa ttcatctagt caaactgtca attaattttt cctcatttca     8580

ttaaaagtgt atatctaatg ctttctctaa aaattgatgt actggaaata caaataaata     8640

aatgctccct gtgtagaatt tc                                              8662


<210>  757
<211>  1285
<212>  PRT
<213>  Homo Sapiens

<400>  757

Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe 
1               5                   10                  15      


Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu 
            20                  25                  30          


Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val 
        35                  40                  45              


Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser 
    50                  55                  60                  


Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg 
65                  70                  75                  80  


Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala 
                85                  90                  95      


Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile 
            100                 105                 110         


Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe 
        115                 120                 125             


Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser 
    130                 135                 140                 


Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn 
145                 150                 155                 160 


Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln 
                165                 170                 175     


Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe 
            180                 185                 190         


Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys 
        195                 200                 205             


Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe 
    210                 215                 220                 


Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys 
225                 230                 235                 240 


Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser 
                245                 250                 255     


Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg 
            260                 265                 270         


Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp 
        275                 280                 285             


Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly 
    290                 295                 300                 


Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met 
305                 310                 315                 320 


Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp 
                325                 330                 335     


Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe 
            340                 345                 350         


Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser 
        355                 360                 365             


Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp 
    370                 375                 380                 


Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly 
385                 390                 395                 400 


Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala 
                405                 410                 415     


Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe 
            420                 425                 430         


Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser 
        435                 440                 445             


Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu 
    450                 455                 460                 


His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu 
465                 470                 475                 480 


Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr 
                485                 490                 495     


Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln 
            500                 505                 510         


Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile 
        515                 520                 525             


Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr 
    530                 535                 540                 


Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro 
545                 550                 555                 560 


Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly 
                565                 570                 575     


Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln 
            580                 585                 590         


Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu 
        595                 600                 605             


Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser 
    610                 615                 620                 


Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe 
625                 630                 635                 640 


Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp 
                645                 650                 655     


Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn 
            660                 665                 670         


Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln 
        675                 680                 685             


Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly 
    690                 695                 700                 


Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys 
705                 710                 715                 720 


Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys 
                725                 730                 735     


Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly 
            740                 745                 750         


Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln 
        755                 760                 765             


Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val 
    770                 775                 780                 


Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser 
785                 790                 795                 800 


Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala 
                805                 810                 815     


Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg 
            820                 825                 830         


His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys 
        835                 840                 845             


Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys 
    850                 855                 860                 


Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr 
865                 870                 875                 880 


Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln 
                885                 890                 895     


Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala 
            900                 905                 910         


Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg 
        915                 920                 925             


Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu 
    930                 935                 940                 


Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met 
945                 950                 955                 960 


Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp 
                965                 970                 975     


Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln 
            980                 985                 990         


Lys Glu Glu Glu Ser Gln Gln Gln  Ala Val Leu Glu Gln  Glu Arg Arg 
        995                 1000                 1005             


Asp Arg  Glu Leu Ala Leu Arg  Ile Ala Gln Ser Glu  Ala Glu Leu 
    1010                 1015                 1020             


Ile Ser  Asp Glu Ala Gln Ala  Asp Leu Ala Leu Arg  Arg Asn Asp 
    1025                 1030                 1035             


Gly Thr  Arg Pro Lys Met Thr  Pro Glu Gln Met Ala  Lys Glu Met 
    1040                 1045                 1050             


Ser Glu  Phe Leu Ser Arg Gly  Pro Ala Val Leu Ala  Thr Lys Ala 
    1055                 1060                 1065             


Ala Ala  Gly Thr Lys Lys Tyr  Asp Leu Ser Lys Trp  Lys Tyr Ala 
    1070                 1075                 1080             


Glu Leu  Arg Asp Thr Ile Asn  Thr Ser Cys Asp Ile  Glu Leu Leu 
    1085                 1090                 1095             


Ala Ala  Cys Arg Glu Glu Phe  His Arg Arg Leu Lys  Val Tyr His 
    1100                 1105                 1110             


Ala Trp  Lys Ser Lys Asn Lys  Lys Arg Asn Thr Glu  Thr Glu Gln 
    1115                 1120                 1125             


Arg Ala  Pro Lys Ser Val Thr  Asp Tyr Asp Phe Ala  Pro Phe Leu 
    1130                 1135                 1140             


Asn Asn  Ser Pro Gln Gln Asn  Pro Ala Ala Gln Ile  Pro Ala Arg 
    1145                 1150                 1155             


Gln Arg  Glu Ile Glu Met Asn  Arg Gln Gln Arg Phe  Phe Arg Ile 
    1160                 1165                 1170             


Pro Phe  Ile Arg Pro Ala Asp  Gln Tyr Lys Asp Pro  Gln Ser Lys 
    1175                 1180                 1185             


Lys Lys  Gly Trp Trp Tyr Ala  His Phe Asp Gly Pro  Trp Ile Ala 
    1190                 1195                 1200             


Arg Gln  Met Glu Leu His Pro  Asp Lys Pro Pro Ile  Leu Leu Val 
    1205                 1210                 1215             


Ala Gly  Lys Asp Asp Met Glu  Met Cys Glu Leu Asn  Leu Glu Glu 
    1220                 1225                 1230             


Thr Gly  Leu Thr Arg Lys Arg  Gly Ala Glu Ile Leu  Pro Arg Gln 
    1235                 1240                 1245             


Phe Glu  Glu Ile Trp Glu Arg  Cys Gly Gly Ile Gln  Tyr Leu Gln 
    1250                 1255                 1260             


Asn Ala  Ile Glu Ser Arg Gln  Ala Arg Pro Thr Tyr  Ala Thr Ala 
    1265                 1270                 1275             


Met Leu  Gln Ser Leu Leu Lys  
    1280                 1285 


<210>  758
<211>  4651
<212>  DNA
<213>  Homo Sapiens

<400>  758
agagagtgcc tcgcgtaggg agcacgagga gaaggaggag cttcgcaggt tgttttttcc       60

caggaggccg actccgccga gtcggtggcg gctgcaggct gggagggaga agtgctacgc      120

ctttgcaggt tggcgaagtg gttccaggct acccggctag tctggcacgg ccccgtcttc      180

tgcctcctcc tccgtcgcgt ggcggcggga actgttggcc gcgcggcctc gggaacggcc      240

caggtccccg cccgcaggtc ccgggcagat aacatagatc atcagtagaa aacttcttga      300

agttgttcaa gaaaaatttg aaagtagcaa aatagaaaat aaagaattaa cagcagatac      360

agaggacagc atggaagtgt tgtcttagga aacagaacac agcagtgaaa aaacagacaa      420

aatccgctca gatacaactg cagctgataa tgttttccgg cttcaatgtc tttagagttg      480

ggatctcttt tgtcataatg tgcatttttt acatgccaac agtaaactct ttaccagaac      540

tgagtcctca gaaatatttt agtacattgc aaccaggaaa agcctcttta gcttattttt      600

gtcaagctga ttccccaaga acatctgtat ttcttgaaga actgaatgag gctgttagac      660

ctctgcagga ctatggaatt tcagttgcca aggttaattg tgtcaaagaa gaaatatcaa      720

gatactgtgg aaaagaaaag gatttgatga aagcatattt attcaagggc aacatattgc      780

tcagagaatt ccctactgac accttgtttg atgtgaatgc cattgtcgcc catgttctct      840

ttgctcttct ttttagtgaa gtgaaatata ttaccaacct ggaagacctt cagaacatag      900

aaaatgctct gaaaggaaaa gcaaatatta tattctcata tgtaagagcc attggaatac      960

cagagcacag agcagtcatg gaagccgctt ttgtgtatgg gactacatac caatttgtct     1020

taaccacaga aattgccctt ttggaaagta ttggctctga ggatgtggaa tatgcacatc     1080

tctacttttt tcattgtaaa ctagtcttgg acttgaccca gcaatgtaga agaacactaa     1140

tggaacagcc attgactaca ctgaacattc acctgtttat taagacaatg aaagcacctc     1200

tgttgactga agttgctgaa gatcctcaac aagtttcaac tgtccatctc caactgggct     1260

taccactggt ttttattgtt agccaacagg ctacttatga agctgataga agaactgcag     1320

aatgggttgc ttggcgtctt ctgggaaaag caggagttct actcttgtta agggactctt     1380

tggaagtgaa cattcctcaa gatgctaatg tggtcttcaa aagagcagaa gagggagttc     1440

cagtggaatt tttggtatta catgatgttg atttaataat atctcatgtg gaaaataata     1500

tgcacattga ggaaatacaa gaagatgaag acaatgacat ggaaggtcca gatatagatg     1560

ttcaggatga tgaagtggca gaaactgttt tcagagatag gaagagaaaa ttacctttgg     1620

aacttacagt ggaactaaca gaagaaacat ttaatgcaac agtgatggct tctgacagca     1680

tagtactctt ctatgctggt tggcaagcag tatccatggc atttttgcaa tcctatattg     1740

atgtggcagt taaactgaaa ggcacatcta ctatgcttct tactagaata aactgtgcag     1800

attggtctga tgtatgtact aagcaaaatg ttactgaatt tcctatcata aagatgtaca     1860

agaaaggcga gaacccagta tcttatgctg gaatgttagg aaccgaagat ctcctaaaat     1920

ttatccagct caacaggatt tcatatccag tgaatataac atcgatccaa gaagcagaag     1980

aatatttaag tggggaatta tataaagacc tcatcttgta ttctagtgtg tcagtattgg     2040

gactatttag tccaaccatg aaaacagcaa aagaagattt tagtgaagca ggaaactacc     2100

taaaaggata tgttatcact ggaatttatt ctgaagaaga tgttttgcta ctgtcaacca     2160

aatatgctgc aagtcttcca gccctgctgc ttgccagaca cacagaaggc aaaatagaga     2220

gcatcccact agctagcaca catgcacaag acatagttca aataataaca gatgcactac     2280

tggaaatgtt tccggaaatc actgtggaaa atcttcccag ttatttcaga cttcagaaac     2340

cattattgat tttgttcagt gatggcactg taaatcctca gtataaaaaa gcaatattga     2400

cactggtaaa gcagaaatac ttggattcat ttactccatg ctggttaaat ctaaagaata     2460

ctccagtggg gagaggaatc ttgagggcat attttgatcc tctgcctccc cttcctcttc     2520

ttgttttggt gaatctgcat tcaggtggcc aagtatttgc atttccttca gaccaggcta     2580

taattgaaga aaaccttgta ttgtggctga agaaattaga agcaggacta gaaaatcata     2640

tcacaatttt acctgctcaa gaatggaaac ctcctcttcc agcttatgat tttctaagta     2700

tgatagatgc cgcaacatct caacgtggca ctaggaaagt tcccaagtgt atgaaagaaa     2760

cagatgtgca ggagaatgat aaggaacaac atgaagataa atcggcagtc agaaaagaac     2820

cgattgaaac tctgagaata aagcattgga atagaagtaa ttggtttaaa gaagcagaaa     2880

aatcatttag acgtgataaa gagttaggat gctcaaaagt gaactaattt tatagggctg     2940

tggtttccaa aatttttttg gcatgataga cttaatttat ttccttaaag aataatatta     3000

aatcatttca agtttgcaga ctagtgccat ccaatagaat tataatataa gtcacatatt     3060

ttatttaaaa ttttctagta actacattaa acaaagtaaa agtgagcagg gcaaaataat     3120

tttgatatta cttttcaccc agtagtatac ccaaaatagc gaaatataga aattattaat     3180

gagatatttt acatcctttt ttgtaccaag tcttctaaat gcagtacata ttttatactt     3240

actgcatttc ttacttccga gtagccatat ttcaagtgtt ccttgccaca tgtggcctgt     3300

gactactgta ttggacagtt cagtactaga caaaaactag cataattaac ttagttctag     3360

ccatgatttc tatttggatt aaaattaaac tctaatcaca gttaactcca cagtgcattc     3420

atgcagctga cagttatatt tgttttattg gagtcatgat attaaaatca gcgtttgtca     3480

acctcagggg atatttagca attgtcggga gacatttttg atgtcatgac tagggcagtt     3540

attgacattt agtgagtaga ggccagggat cctgctaaat aacctgcatt ggacagcgcc     3600

ccacaacaaa gaattatcct gcccgaaatg gtagtcgtgc caaggctgag taaccttgtg     3660

ttaaaagtaa cctgtggcag actaggtttc cagaatttcc tggttctgct cacgtatcat     3720

gtttgaaaaa attttggcta ttaaagatat gtattagatg gtcttatcct gattattacc     3780

tggatacaac ttgatctttt ctaatatttt cagaaagtga tgggataacc ctagaagagg     3840

actcagaatg atatttatat tttaagtgag tcttaaaacc tcctcttatt tctacaagtt     3900

atatggctaa atttcagatt gaacagggat tcagcattct gccatctcct catggaaaga     3960

gaggctccct catctgaagc gtctctgaaa tctacccttg caagcttcag acaaatcagt     4020

tgatctccct gagccacacg gcctcattct gtgagggagg gaaagattag ccaaagagtt     4080

aattttcatt ccaaatcact tagctgttag actgatctgt ttgtagcagt tgtttgtctc     4140

atttttgctc tgtgcatttt ttgagacatt tgttgagaat attctatttg gtgctctact     4200

gtatttttct ttttaatatc tacttgatat cttgttcttt aaattttctt cacatatggt     4260

ttgcctgata caactgattt ttataactga aatttaagga atctaacagc taaaactcag     4320

taagtgcata tatttcctta taacatagac ccgttgctac tctcagcacc ctctcctcaa     4380

ttttttttcc tgtagcatgt gatgcctgat taaactcatt ttcatttgct tttatttcta     4440

atatgggaac aatgagagtg aactctaaat ataggttgta gtaataaaac atcattagcc     4500

taattattag aaaatgctaa ttaagtacca gcacatagaa acatgaaatt gcttagtcat     4560

tgtacctttg tcagcaattt tgacagtcat taatgtttgt cataatttta aataaagtgt     4620

ctgggtttca gaataccttc aaaaaaaaaa a                                    4651


<210>  759
<211>  825
<212>  PRT
<213>  Homo Sapiens

<400>  759

Met Phe Ser Gly Phe Asn Val Phe Arg Val Gly Ile Ser Phe Val Ile 
1               5                   10                  15      


Met Cys Ile Phe Tyr Met Pro Thr Val Asn Ser Leu Pro Glu Leu Ser 
            20                  25                  30          


Pro Gln Lys Tyr Phe Ser Thr Leu Gln Pro Gly Lys Ala Ser Leu Ala 
        35                  40                  45              


Tyr Phe Cys Gln Ala Asp Ser Pro Arg Thr Ser Val Phe Leu Glu Glu 
    50                  55                  60                  


Leu Asn Glu Ala Val Arg Pro Leu Gln Asp Tyr Gly Ile Ser Val Ala 
65                  70                  75                  80  


Lys Val Asn Cys Val Lys Glu Glu Ile Ser Arg Tyr Cys Gly Lys Glu 
                85                  90                  95      


Lys Asp Leu Met Lys Ala Tyr Leu Phe Lys Gly Asn Ile Leu Leu Arg 
            100                 105                 110         


Glu Phe Pro Thr Asp Thr Leu Phe Asp Val Asn Ala Ile Val Ala His 
        115                 120                 125             


Val Leu Phe Ala Leu Leu Phe Ser Glu Val Lys Tyr Ile Thr Asn Leu 
    130                 135                 140                 


Glu Asp Leu Gln Asn Ile Glu Asn Ala Leu Lys Gly Lys Ala Asn Ile 
145                 150                 155                 160 


Ile Phe Ser Tyr Val Arg Ala Ile Gly Ile Pro Glu His Arg Ala Val 
                165                 170                 175     


Met Glu Ala Ala Phe Val Tyr Gly Thr Thr Tyr Gln Phe Val Leu Thr 
            180                 185                 190         


Thr Glu Ile Ala Leu Leu Glu Ser Ile Gly Ser Glu Asp Val Glu Tyr 
        195                 200                 205             


Ala His Leu Tyr Phe Phe His Cys Lys Leu Val Leu Asp Leu Thr Gln 
    210                 215                 220                 


Gln Cys Arg Arg Thr Leu Met Glu Gln Pro Leu Thr Thr Leu Asn Ile 
225                 230                 235                 240 


His Leu Phe Ile Lys Thr Met Lys Ala Pro Leu Leu Thr Glu Val Ala 
                245                 250                 255     


Glu Asp Pro Gln Gln Val Ser Thr Val His Leu Gln Leu Gly Leu Pro 
            260                 265                 270         


Leu Val Phe Ile Val Ser Gln Gln Ala Thr Tyr Glu Ala Asp Arg Arg 
        275                 280                 285             


Thr Ala Glu Trp Val Ala Trp Arg Leu Leu Gly Lys Ala Gly Val Leu 
    290                 295                 300                 


Leu Leu Leu Arg Asp Ser Leu Glu Val Asn Ile Pro Gln Asp Ala Asn 
305                 310                 315                 320 


Val Val Phe Lys Arg Ala Glu Glu Gly Val Pro Val Glu Phe Leu Val 
                325                 330                 335     


Leu His Asp Val Asp Leu Ile Ile Ser His Val Glu Asn Asn Met His 
            340                 345                 350         


Ile Glu Glu Ile Gln Glu Asp Glu Asp Asn Asp Met Glu Gly Pro Asp 
        355                 360                 365             


Ile Asp Val Gln Asp Asp Glu Val Ala Glu Thr Val Phe Arg Asp Arg 
    370                 375                 380                 


Lys Arg Lys Leu Pro Leu Glu Leu Thr Val Glu Leu Thr Glu Glu Thr 
385                 390                 395                 400 


Phe Asn Ala Thr Val Met Ala Ser Asp Ser Ile Val Leu Phe Tyr Ala 
                405                 410                 415     


Gly Trp Gln Ala Val Ser Met Ala Phe Leu Gln Ser Tyr Ile Asp Val 
            420                 425                 430         


Ala Val Lys Leu Lys Gly Thr Ser Thr Met Leu Leu Thr Arg Ile Asn 
        435                 440                 445             


Cys Ala Asp Trp Ser Asp Val Cys Thr Lys Gln Asn Val Thr Glu Phe 
    450                 455                 460                 


Pro Ile Ile Lys Met Tyr Lys Lys Gly Glu Asn Pro Val Ser Tyr Ala 
465                 470                 475                 480 


Gly Met Leu Gly Thr Glu Asp Leu Leu Lys Phe Ile Gln Leu Asn Arg 
                485                 490                 495     


Ile Ser Tyr Pro Val Asn Ile Thr Ser Ile Gln Glu Ala Glu Glu Tyr 
            500                 505                 510         


Leu Ser Gly Glu Leu Tyr Lys Asp Leu Ile Leu Tyr Ser Ser Val Ser 
        515                 520                 525             


Val Leu Gly Leu Phe Ser Pro Thr Met Lys Thr Ala Lys Glu Asp Phe 
    530                 535                 540                 


Ser Glu Ala Gly Asn Tyr Leu Lys Gly Tyr Val Ile Thr Gly Ile Tyr 
545                 550                 555                 560 


Ser Glu Glu Asp Val Leu Leu Leu Ser Thr Lys Tyr Ala Ala Ser Leu 
                565                 570                 575     


Pro Ala Leu Leu Leu Ala Arg His Thr Glu Gly Lys Ile Glu Ser Ile 
            580                 585                 590         


Pro Leu Ala Ser Thr His Ala Gln Asp Ile Val Gln Ile Ile Thr Asp 
        595                 600                 605             


Ala Leu Leu Glu Met Phe Pro Glu Ile Thr Val Glu Asn Leu Pro Ser 
    610                 615                 620                 


Tyr Phe Arg Leu Gln Lys Pro Leu Leu Ile Leu Phe Ser Asp Gly Thr 
625                 630                 635                 640 


Val Asn Pro Gln Tyr Lys Lys Ala Ile Leu Thr Leu Val Lys Gln Lys 
                645                 650                 655     


Tyr Leu Asp Ser Phe Thr Pro Cys Trp Leu Asn Leu Lys Asn Thr Pro 
            660                 665                 670         


Val Gly Arg Gly Ile Leu Arg Ala Tyr Phe Asp Pro Leu Pro Pro Leu 
        675                 680                 685             


Pro Leu Leu Val Leu Val Asn Leu His Ser Gly Gly Gln Val Phe Ala 
    690                 695                 700                 


Phe Pro Ser Asp Gln Ala Ile Ile Glu Glu Asn Leu Val Leu Trp Leu 
705                 710                 715                 720 


Lys Lys Leu Glu Ala Gly Leu Glu Asn His Ile Thr Ile Leu Pro Ala 
                725                 730                 735     


Gln Glu Trp Lys Pro Pro Leu Pro Ala Tyr Asp Phe Leu Ser Met Ile 
            740                 745                 750         


Asp Ala Ala Thr Ser Gln Arg Gly Thr Arg Lys Val Pro Lys Cys Met 
        755                 760                 765             


Lys Glu Thr Asp Val Gln Glu Asn Asp Lys Glu Gln His Glu Asp Lys 
    770                 775                 780                 


Ser Ala Val Arg Lys Glu Pro Ile Glu Thr Leu Arg Ile Lys His Trp 
785                 790                 795                 800 


Asn Arg Ser Asn Trp Phe Lys Glu Ala Glu Lys Ser Phe Arg Arg Asp 
                805                 810                 815     


Lys Glu Leu Gly Cys Ser Lys Val Asn 
            820                 825 


<210>  760
<211>  3669
<212>  DNA
<213>  Homo Sapiens

<400>  760
gcgaggcccc aagctggccc gggagaggac tctgcgggcg aagtggctgc gcaaggagag       60

aacttttcct gcacaaggaa cgcctcgtgg ggagacccaa ggcaggagcg gtccggagcc      120

ggctgcggcg tgtgcggccg gccttgggac agcgatcgcc gcgggtggca acagagagcc      180

ccaagcaaaa gtgggagcag gagcttggag gtgagcacag gaagccccac ttgaggcttt      240

tacgcagcct ctagtctctg tttcttctgg aataggcaag tgtcctttca actctaagag      300

accagcagag gccactgtcc cttaagactg ccggagtcct caccacttct ccaggattcc      360

agaggagact gtggcgatgg tgaatgaagg tcccaaccag gaagagagcg atgacacccc      420

tgtgccggag tccgcactcc aagcggaccc cagcgtctcg gtccatccca gcgtctcggt      480

ccatcccagc gtctccatca accccagcgt ctctgtccac cccagcagtt cggcccaccc      540

cagtgcctta gcccaaccca gtggcttggc tcaccccagt agctcgggcc ctgaggacct      600

cagcgtgatc aaggtgagca ggcgccgttg ggccgtggtc ctggtgttta gctgctactc      660

catgtgcaac tcctttcagt ggatccagta cggctccatc aataacatct tcatgcactt      720

ctacggtgtc agtgcctttg ccattgactg gctgtccatg tgctacatgc tgacttacat      780

ccctctgctc ctgccagtgg cttggctgct ggagaagttc ggcctgcgca ccattgctct      840

cactggctcg gctctcaact gcctgggggc ctgggtgaag ctgggcagcc tgaagccgca      900

tctctttccg gtcaccgtgg tgggccagct catctgctct gtggcccagg ttttcatcct      960

gggcatgccc tcccgcatcg cttccgtctg gttcggggct aatgaggttt caacagcctg     1020

ctccgtggct gtctttggca atcagcttgg aattgcgatt gggttcttgg tccctcctgt     1080

tttggtaccc aacattgaag accgggacga gcttgcctac cacatcagca tcatgttcta     1140

tataatagga ggtgtggcca ctctcctcct catccttgtc atcattgtgt tcaaggagaa     1200

acctaaatat ccccccagca gggcccaatc cctgagctat gccttgacct ctcctgatgc     1260

ctcatactta ggttccatcg cccggctctt caaaaatctc aactttgtgc tgcttgtcat     1320

cacctatggt ctgaatgctg gtgcttttta tgccttgtcc actcttctga atcgcatggt     1380

gatctggcac tacccggggg aagaagtgaa tgctggaaga attggcctga cgatcgtcat     1440

tgcaggaatg cttggggctg tgatctcagg aatctggctg gataggtcca aaacctacaa     1500

agagacaacc ctggtagtct atatcatgac actggtgggc atggtggtgt acacgtttac     1560

cttgaacctg ggacacctgt gggtagtgtt catcactgct ggcacaatgg gcttctttat     1620

gactggctat ctcccactgg gatttgagtt tgctgtggag ctcacgtacc cagaatcaga     1680

aggcatctcc tccggcctcc tcaacatatc tgcacaggta tttgggatca tctttaccat     1740

ctcccagggc cagattattg acaactatgg aaccaagcct gggaacatct tcctgtgtgt     1800

gttccttact cttggagcag ccctcactgc attcattaag gcagatctcc ggagacagaa     1860

agcaaacaaa gaaactcttg agaacaaact ccaagaggag gaggaggaga gcaacaccag     1920

caaagtgccc actgctgtgt cagaggatca tctctgagag gaaggtggtg acaactcagg     1980

gaacacgaac accccacctt ttccttcagc acagctctca ccgccagcac aaagggcttc     2040

gctagagatg tttttggagg gaatcagtgg gactatttgt ggcatggatg gcctattcct     2100

cctagaaccc acgtaagagc ttggatgatt tagttggaga aaattgcacc tatcaccaaa     2160

tgcaaatttg attcccacct ccaccccctt ttaggttatg ggagttggtg ttgggacagg     2220

gtggcagaga atattggagt caatcctagc ttggtctctt gccttccctc ttttcctcca     2280

tccatcgtgg acaatgcctg caaaattttc acaggaagaa agcctattca ggatattaac     2340

ttgaaatttc cagtgtccta agagcctctc atgaagccca gttctaataa gtggcaagct     2400

gctctgccgg ggtcatctcc tgggtcatcg gactgattgc tcaagttctg caggagagga     2460

agcaccatta gaacaactcc atcagaacag ctccaccggg acttgtgggc ctaaattttc     2520

ctggcctaac gggtctgtct ccaaaccctc tttcctaaga gctgagcaaa ccaaccataa     2580

taaacttgac aaaagacttt gttgtggcca tgacagagat accgactcag gagggctacc     2640

tacctaggtg tgatcatgct gggggctacc ttctgagtat atttgtgaaa gcacatattt     2700

gggaactctg gtagcttgag ttgggaatgg gaaggttctt ttttacagaa gtacttcccc     2760

agggacttct gtgtgtcaca gtcacctctg atgcctttat cttgatgttg cattgggaat     2820

ctcagccatc agcccaagtg cttgttttat tccaaggcag ggtaatcccc gtcaacttac     2880

tctaaccttt gctgaaaact aatcttgatt cattctactc tgaaaatcca aaggtgcttc     2940

tgagagataa gagggaaggg gtagaaggaa aggtgcccct tgaaatggga attgagcctg     3000

ttagaattaa aagcttatct cacctctgct ggggacagta tttgcaccac caacccctct     3060

cctcacctgc tttgagcgat aatctttatc agatattcta aacttaaagg gattcccttt     3120

aaaccaactc aagctgatct ttcctatcta gcctgctgtt tggctgtact catgggcttt     3180

ggtaatatct cctaaaaatg aggttttggt aatttttcct atgcattggg caactgtgat     3240

cgtgaccact gtgctgtctt gctccagcca ctgccctggc ctcagcatat cagggcagcc     3300

tgtgctggct gcaatactgt ggtgcttggg ccactgcctg agaggagcca ggtttgtgtg     3360

tgtctgcatg tgtgtgtgtg tgtgtttgta cagattcaag caatggatgc aaggaacatg     3420

ctgtatgtaa tagaagaaag aagtccacgt tttcggcaga agtagtgagt cagtgtggaa     3480

gagaggtgag ggtgtgcttt actttttgat aaagagaaag atgtttactc ataaaccctt     3540

caaaaggtat taacaaaatg tttaccaaac ctattgcttt attttaaaaa cataatttgt     3600

gttttctatt tgtaagatct gacatttcga ggcaataaaa acttctcaga aagtaaaaaa     3660

aaaaaaaaa                                                             3669


<210>  761
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  761

Met Val Asn Glu Gly Pro Asn Gln Glu Glu Ser Asp Asp Thr Pro Val 
1               5                   10                  15      


Pro Glu Ser Ala Leu Gln Ala Asp Pro Ser Val Ser Val His Pro Ser 
            20                  25                  30          


Val Ser Val His Pro Ser Val Ser Ile Asn Pro Ser Val Ser Val His 
        35                  40                  45              


Pro Ser Ser Ser Ala His Pro Ser Ala Leu Ala Gln Pro Ser Gly Leu 
    50                  55                  60                  


Ala His Pro Ser Ser Ser Gly Pro Glu Asp Leu Ser Val Ile Lys Val 
65                  70                  75                  80  


Ser Arg Arg Arg Trp Ala Val Val Leu Val Phe Ser Cys Tyr Ser Met 
                85                  90                  95      


Cys Asn Ser Phe Gln Trp Ile Gln Tyr Gly Ser Ile Asn Asn Ile Phe 
            100                 105                 110         


Met His Phe Tyr Gly Val Ser Ala Phe Ala Ile Asp Trp Leu Ser Met 
        115                 120                 125             


Cys Tyr Met Leu Thr Tyr Ile Pro Leu Leu Leu Pro Val Ala Trp Leu 
    130                 135                 140                 


Leu Glu Lys Phe Gly Leu Arg Thr Ile Ala Leu Thr Gly Ser Ala Leu 
145                 150                 155                 160 


Asn Cys Leu Gly Ala Trp Val Lys Leu Gly Ser Leu Lys Pro His Leu 
                165                 170                 175     


Phe Pro Val Thr Val Val Gly Gln Leu Ile Cys Ser Val Ala Gln Val 
            180                 185                 190         


Phe Ile Leu Gly Met Pro Ser Arg Ile Ala Ser Val Trp Phe Gly Ala 
        195                 200                 205             


Asn Glu Val Ser Thr Ala Cys Ser Val Ala Val Phe Gly Asn Gln Leu 
    210                 215                 220                 


Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val Pro Asn Ile 
225                 230                 235                 240 


Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met Phe Tyr Ile 
                245                 250                 255     


Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile Ile Val Phe 
            260                 265                 270         


Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser Leu Ser Tyr 
        275                 280                 285             


Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile Ala Arg Leu 
    290                 295                 300                 


Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr Gly Leu Asn 
305                 310                 315                 320 


Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg Met Val Ile 
                325                 330                 335     


Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile Gly Leu Thr 
            340                 345                 350         


Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly Ile Trp Leu 
        355                 360                 365             


Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val Tyr Ile Met 
    370                 375                 380                 


Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn Leu Gly His 
385                 390                 395                 400 


Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe Phe Met Thr 
                405                 410                 415     


Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu Thr Tyr Pro 
            420                 425                 430         


Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser Ala Gln Val 
        435                 440                 445             


Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile Asp Asn Tyr 
    450                 455                 460                 


Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu Thr Leu Gly 
465                 470                 475                 480 


Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg Gln Lys Ala 
                485                 490                 495     


Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu Glu Glu Ser 
            500                 505                 510         


Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His Leu 
        515                 520                 525     


<210>  762
<211>  5843
<212>  DNA
<213>  Homo Sapiens

<400>  762
gagcggacag gcgtggcggc cggagcccca gcatccctgc ttgaggtcca ggagcggagc       60

ccgcggccac cgccgcctga tcagcgcgac cccggcccgc gcccgccccg cccggcaaga      120

tgctgcccgt gtaccaggag gtgaagccca acccgctgca ggacgcgaac ctctgctcac      180

gcgtgttctt ctggtggctc aatcccttgt ttaaaattgg ccataaacgg agattagagg      240

aagatgatat gtattcagtg ctgccagaag accgctcaca gcaccttgga gaggagttgc      300

aagggttctg ggataaagaa gttttaagag ctgagaatga cgcacagaag ccttctttaa      360

caagagcaat cataaagtgt tactggaaat cttatttagt tttgggaatt tttacgttaa      420

ttgaggaaag tgccaaagta atccagccca tatttttggg aaaaattatt aattattttg      480

aaaattatga tcccatggat tctgtggctt tgaacacagc gtacgcctat gccacggtgc      540

tgactttttg cacgctcatt ttggctatac tgcatcactt atatttttat cacgttcagt      600

gtgctgggat gaggttacga gtagccatgt gccatatgat ttatcggaag gcacttcgtc      660

ttagtaacat ggccatgggg aagacaacca caggccagat agtcaatctg ctgtccaatg      720

atgtgaacaa gtttgatcag gtgacagtgt tcttacactt cctgtgggca ggaccactgc      780

aggcgattgc agtgactgcc ctactctgga tggagatagg aatatcgtgc cttgctggga      840

tggcagttct aatcattctc ctgcccttgc aaagctgttt tgggaagttg ttctcatcac      900

tgaggagtaa aactgcaact ttcacggatg ccaggatcag gaccatgaat gaagttataa      960

ctggtataag gataataaaa atgtacgcct gggaaaagtc attttcaaat cttattacca     1020

atttgagaaa gaaggagatt tccaagattc tgagaagttc ctgcctcaga gggatgaatt     1080

tggcttcatt tttcagtgca agcaaaatca tcgtgtttgt gaccttcacc acctacgtgc     1140

tcctcggcag tgtgatcaca gccagccgcg tgttcgtggc agtgacgctg tatggggctg     1200

tgcggctgac ggttaccctc ttcttcccct cagccattga gagggtgtca gaggcaatcg     1260

tcagcatccg aagaatccag acctttttgc tacttgatga gatatcacag cgcaaccgtc     1320

agctgccgtc agatggtaaa aagatggtgc atgtgcagga ttttactgct ttttgggata     1380

aggcatcaga gaccccaact ctacaaggcc tttcctttac tgtcagacct ggcgaattgt     1440

tagctgtggt cggccccgtg ggagcaggga agtcatcact gttaagtgcc gtgctcgggg     1500

aattggcccc aagtcacggg ctggtcagcg tgcatggaag aattgcctat gtgtctcagc     1560

agccctgggt gttctcggga actctgagga gtaatatttt atttgggaag aaatacgaaa     1620

aggaacgata tgaaaaagtc ataaaggctt gtgctctgaa aaaggattta cagctgttgg     1680

aggatggtga tctgactgtg ataggagatc ggggaaccac gctgagtgga gggcagaaag     1740

cacgggtaaa ccttgcaaga gcagtgtatc aagatgctga catctatctc ctggacgatc     1800

ctctcagtgc agtagatgcg gaagttagca gacacttgtt cgaactgtgt atttgtcaaa     1860

ttttgcatga gaagatcaca attttagtga ctcatcagtt gcagtacctc aaagctgcaa     1920

gtcagattct gatattgaaa gatggtaaaa tggtgcagaa ggggacttac actgagttcc     1980

taaaatctgg tatagatttt ggctcccttt taaagaagga taatgaggaa agtgaacaac     2040

ctccagttcc aggaactccc acactaagga atcgtacctt ctcagagtct tcggtttggt     2100

ctcaacaatc ttctagaccc tccttgaaag atggtgctct ggagagccaa gatacagaga     2160

atgtcccagt tacactatca gaggagaacc gttctgaagg aaaagttggt tttcaggcct     2220

ataagaatta cttcagagct ggtgctcact ggattgtctt cattttcctt attctcctaa     2280

acactgcagc tcaggttgcc tatgtgcttc aagattggtg gctttcatac tgggcaaaca     2340

aacaaagtat gctaaatgtc actgtaaatg gaggaggaaa tgtaaccgag aagctagatc     2400

ttaactggta cttaggaatt tattcaggtt taactgtagc taccgttctt tttggcatag     2460

caagatctct attggtattc tacgtccttg ttaactcttc acaaactttg cacaacaaaa     2520

tgtttgagtc aattctgaaa gctccggtat tattctttga tagaaatcca ataggaagaa     2580

ttttaaatcg tttctccaaa gacattggac acttggatga tttgctgccg ctgacgtttt     2640

tagatttcat ccagacattg ctacaagtgg ttggtgtggt ctctgtggct gtggccgtga     2700

ttccttggat cgcaataccc ttggttcccc ttggaatcat tttcattttt cttcggcgat     2760

attttttgga aacgtcaaga gatgtgaagc gcctggaatc tacaactcgg agtccagtgt     2820

tttcccactt atcatcttct ctccaggggc tctggaccat ccgggcatac aaagcagaag     2880

agaggtgtca ggaactgttt gatgcacacc aggatttaca ttcagaggct tggttcttgt     2940

ttttgacaac gtcccgctgg tttgccgtcc gtctggatgc catctgtgcc atgtttgtca     3000

tcatcgttgc ctttgggtcc ctgattctgg caaaaactct ggatgccggg caggttggtt     3060

tggcactgtc ctatgccctc acgctcatgg ggatgtttca gtggtgtgtt cgacaaagtg     3120

ctgaagttga gaatatgatg atctcagtag aaagggtcat tgaatacaca gaccttgaaa     3180

aagaagcacc ttgggaatat cagaaacgcc caccaccagc ctggccccat gaaggagtga     3240

taatctttga caatgtgaac ttcatgtaca gtccaggtgg gcctctggta ctgaagcatc     3300

tgacagcact cattaaatca caagaaaagg ttggcattgt gggaagaacc ggagctggaa     3360

aaagttccct catctcagcc ctttttagat tgtcagaacc cgaaggtaaa atttggattg     3420

ataagatctt gacaactgaa attggacttc acgatttaag gaagaagatg tcaatcatac     3480

ctcaggaacc tgttttgttc actggaacaa tgaggaaaaa cctggatccc tttaatgagc     3540

acacggatga ggaactgtgg aatgccttac aagaggtaca acttaaagaa accattgaag     3600

atcttcctgg taaaatggat actgaattag cagaatcagg atccaatttt agtgttggac     3660

aaagacaact ggtgtgcctt gccagggcaa ttctcaggaa aaatcagata ttgattattg     3720

atgaagcgac ggcaaatgtg gatccaagaa ctgatgagtt aatacaaaaa aaaatccggg     3780

agaaatttgc ccactgcacc gtgctaacca ttgcacacag attgaacacc attattgaca     3840

gcgacaagat aatggtttta gattcaggaa gactgaaaga atatgatgag ccgtatgttt     3900

tgctgcaaaa taaagagagc ctattttaca agatggtgca acaactgggc aaggcagaag     3960

ccgctgccct cactgaaaca gcaaaacagg tatacttcaa aagaaattat ccacatattg     4020

gtcacactga ccacatggtt acaaacactt ccaatggaca gccctcgacc ttaactattt     4080

tcgagacagc actgtgaatc caaccaaaat gtcaagtccg ttccgaaggc attttccact     4140

agtttttgga ctatgtaaac cacattgtac ttttttttac tttggcaaca aatatttata     4200

catacaagat gctagttcat ttgaatattt ctcccaactt atccaaggat ctccagctct     4260

aacaaaatgg tttattttta tttaaatgtc aatagttgtt ttttaaaatc caaatcagag     4320

gtgcaggcca ccagttaaat gccgtctatc aggttttgtg ccttaagaga ctacagagtc     4380

aaagctcatt tttaaaggag taggacaaag ttgtcacagg tttttgttgt tgtttttatt     4440

gcccccaaaa ttacatgtta atttccattt atatcaggga ttctatttac ttgaagactg     4500

tgaagttgcc attttgtctc attgttttct ttgacataac taggatccat tatttcccct     4560

gaaggcttct tgttagaaaa tagtacagtt acaaccaata ggaacaacaa aaagaaaaag     4620

tttgtgacat tgtagtaggg agtgtgtacc ccttactccc catcaaaaaa aaaaatggat     4680

acatggttaa aggatagaag ggcaatattt tatcatatgt tctaaaagag aaggaagaga     4740

aaatactact ttctcaaaat ggaagccctt aaaggtgctt tgatactgaa ggacacaaat     4800

gtgaccgtcc atcctccttt agagttgcat gacttggaca cggtaactgt tgcagtttta     4860

gactcagcat tgtgacactt cccaagaagg ccaaacctct aaccgacatt cctgaaatac     4920

gtggcattat tcttttttgg atttctcatt tatggaaggc taaccctctg ttgactgtaa     4980

gccttttggt ttgggctgta ttgaaatcct ttctaaattg catgaatagg ctctgctaac     5040

gtgatgagac aaactgaaaa ttattgcaag cattgactat aattatgcag tacgttctca     5100

ggatgcatcc aggggttcat tttcatgagc ctgtccaggt tagtttactc ctgaccacta     5160

atagcattgt catttgggct ttctgttgaa tgaatcaaca aaccacaata cttcctggga     5220

ccttttgtac tttatttgaa ctatgagtct ttaatttttc ctgatgatgg tggctgtaat     5280

atgttgagtt cagtttacta aaggttttac tattatggtt tgaagtggag tctcatgacc     5340

tctcagaata aggtgtcacc tccctgaaat tgcatatatg tatatagaca tgcacacgtg     5400

tgcatttgtt tgtatacata tatttgtcct tcgtatagca agttttttgc tcatcagcag     5460

agagcaacag atgttttatt gagtgaagcc ttaaaaagca cacaccacac acagctaact     5520

gccaaaatac attgaccgta gtagctgttc aactcctagt acttagaaat acacgtatgg     5580

ttaatgttca gtccaacaaa ccacacacag taaatgttta ttaatagtca tggttcgtat     5640

tttaggtgac tgaaattgca tcagtgatca taatgaggtt tgttaaaacg atagctatat     5700

tcaaaatgtc tatatgttta tttggacttt tgaggttaaa gacagtcata taaacgtcct     5760

gtttctgttt taatgttatc atagaatttt ttaatgaaac taaattcaat tgaaataaat     5820

gatagttttc atctccattc aga                                             5843


<210>  763
<211>  1325
<212>  PRT
<213>  Homo Sapiens

<400>  763

Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 
1               5                   10                  15      


Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 
            20                  25                  30          


Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 
    50                  55                  60                  


Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 
65                  70                  75                  80  


Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 
                85                  90                  95      


Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 
            100                 105                 110         


Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 
        115                 120                 125             


Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 
    130                 135                 140                 


Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 
145                 150                 155                 160 


Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 
                165                 170                 175     


Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 
            180                 185                 190         


Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 
        195                 200                 205             


Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 
    210                 215                 220                 


Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 
225                 230                 235                 240 


Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 
                245                 250                 255     


Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 
            260                 265                 270         


Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 
        275                 280                 285             


Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 
    290                 295                 300                 


Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 
305                 310                 315                 320 


Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 
                325                 330                 335     


Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 
            340                 345                 350         


Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 
        355                 360                 365             


Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 
    370                 375                 380                 


Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 
385                 390                 395                 400 


Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 
                405                 410                 415     


Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 
            420                 425                 430         


Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 
        435                 440                 445             


Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 
    450                 455                 460                 


Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 
465                 470                 475                 480 


Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 
                485                 490                 495     


Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 
            500                 505                 510         


Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 
        515                 520                 525             


Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 
    530                 535                 540                 


Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 
                565                 570                 575     


Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 
            580                 585                 590         


Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 
        595                 600                 605             


Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 
    610                 615                 620                 


Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 
625                 630                 635                 640 


Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 
                645                 650                 655     


Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 
            660                 665                 670         


Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 
        675                 680                 685             


Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 
    690                 695                 700                 


Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 
705                 710                 715                 720 


Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 
                725                 730                 735     


Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 
            740                 745                 750         


Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 
        755                 760                 765             


Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 
    770                 775                 780                 


Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 
785                 790                 795                 800 


Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 
                805                 810                 815     


Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 
            820                 825                 830         


Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Thr Leu Leu 
        835                 840                 845             


Gln Val Val Gly Val Val Ser Val Ala Val Ala Val Ile Pro Trp Ile 
    850                 855                 860                 


Ala Ile Pro Leu Val Pro Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg 
865                 870                 875                 880 


Tyr Phe Leu Glu Thr Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr 
                885                 890                 895     


Arg Ser Pro Val Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp 
            900                 905                 910         


Thr Ile Arg Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp 
        915                 920                 925             


Ala His Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr 
    930                 935                 940                 


Ser Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val 
945                 950                 955                 960 


Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp Ala 
                965                 970                 975     


Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met Gly Met 
            980                 985                 990         


Phe Gln Trp Cys Val Arg Gln Ser  Ala Glu Val Glu Asn  Met Met Ile 
        995                 1000                 1005             


Ser Val  Glu Arg Val Ile Glu  Tyr Thr Asp Leu Glu  Lys Glu Ala 
    1010                 1015                 1020             


Pro Trp  Glu Tyr Gln Lys Arg  Pro Pro Pro Ala Trp  Pro His Glu 
    1025                 1030                 1035             


Gly Val  Ile Ile Phe Asp Asn  Val Asn Phe Met Tyr  Ser Pro Gly 
    1040                 1045                 1050             


Gly Pro  Leu Val Leu Lys His  Leu Thr Ala Leu Ile  Lys Ser Gln 
    1055                 1060                 1065             


Glu Lys  Val Gly Ile Val Gly  Arg Thr Gly Ala Gly  Lys Ser Ser 
    1070                 1075                 1080             


Leu Ile  Ser Ala Leu Phe Arg  Leu Ser Glu Pro Glu  Gly Lys Ile 
    1085                 1090                 1095             


Trp Ile  Asp Lys Ile Leu Thr  Thr Glu Ile Gly Leu  His Asp Leu 
    1100                 1105                 1110             


Arg Lys  Lys Met Ser Ile Ile  Pro Gln Glu Pro Val  Leu Phe Thr 
    1115                 1120                 1125             


Gly Thr  Met Arg Lys Asn Leu  Asp Pro Phe Asn Glu  His Thr Asp 
    1130                 1135                 1140             


Glu Glu  Leu Trp Asn Ala Leu  Gln Glu Val Gln Leu  Lys Glu Thr 
    1145                 1150                 1155             


Ile Glu  Asp Leu Pro Gly Lys  Met Asp Thr Glu Leu  Ala Glu Ser 
    1160                 1165                 1170             


Gly Ser  Asn Phe Ser Val Gly  Gln Arg Gln Leu Val  Cys Leu Ala 
    1175                 1180                 1185             


Arg Ala  Ile Leu Arg Lys Asn  Gln Ile Leu Ile Ile  Asp Glu Ala 
    1190                 1195                 1200             


Thr Ala  Asn Val Asp Pro Arg  Thr Asp Glu Leu Ile  Gln Lys Lys 
    1205                 1210                 1215             


Ile Arg  Glu Lys Phe Ala His  Cys Thr Val Leu Thr  Ile Ala His 
    1220                 1225                 1230             


Arg Leu  Asn Thr Ile Ile Asp  Ser Asp Lys Ile Met  Val Leu Asp 
    1235                 1240                 1245             


Ser Gly  Arg Leu Lys Glu Tyr  Asp Glu Pro Tyr Val  Leu Leu Gln 
    1250                 1255                 1260             


Asn Lys  Glu Ser Leu Phe Tyr  Lys Met Val Gln Gln  Leu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Ala Ala Ala Leu Thr  Glu Thr Ala Lys Gln  Val Tyr Phe 
    1280                 1285                 1290             


Lys Arg  Asn Tyr Pro His Ile  Gly His Thr Asp His  Met Val Thr 
    1295                 1300                 1305             


Asn Thr  Ser Asn Gly Gln Pro  Ser Thr Leu Thr Ile  Phe Glu Thr 
    1310                 1315                 1320             


Ala Leu  
    1325 


<210>  764
<211>  4553
<212>  DNA
<213>  Homo Sapiens

<400>  764
acgcgtctgc ggccagcccg gactctttaa aagccggcgg tgcgcggggc atcccagcca       60

agccggagag gaggcgagca gcagggcctg gtggcgagag cgcggctgtc actgcgcccg      120

agcatcccag agctttccga gcggacgagc cggccgtgcc gggcatcccc agcctcgcta      180

ccctcgcagc acacgtcgag ccccgcacag gcgagggtcc ggaacttagc ccaaagcacg      240

tttcccctgg cagcgcagga aacgcccggc cgcgcgccgg cgcacgcccc cctctcctcc      300

tttgttccgg gggtcggcgg ccgctctcct gccagcgtcg ggatctcggc cccgggaggc      360

gggccgtcgg gcgcagccgc gaagatgccg ttggaactga cgcagagccg agtgcagaag      420

atctgggtgc ccgtggacca caggccctcg ttgcccagat cctgtgggcc aaagctgacc      480

aactccccca ccgtcatcgt catggtgggc ctccccgccc ggggcaagac ctacatctcc      540

aagaagctga ctcgctacct caactggatt ggcgtcccca caaaagtgtt caacgtcggg      600

gagtatcgcc gggaggctgt gaagcagtac agctcctaca acttcttccg ccccgacaat      660

gaggaagcca tgaaagtccg gaagcaatgt gccttagctg ccttgagaga tgtcaaaagc      720

tacctggcga aagaaggggg acaaattgcg gttttcgatg ccaccaatac tactagagag      780

aggagacaca tgatccttca ttttgccaaa gaaaatgact ttaaggcgtt tttcatcgag      840

tcggtgtgcg acgaccctac agttgtggcc tccaatatca tggaagttaa aatctccagc      900

ccggattaca aagactgcaa ctcggcagaa gccatggacg acttcatgaa gaggatcagt      960

tgctatgaag ccagctacca gcccctcgac cccgacaaat gcgacaggga cttgtcgctg     1020

atcaaggtga ttgacgtggg ccggaggttc ctggtgaacc gggtgcagga ccacatccag     1080

agccgcatcg tgtactacct gatgaacatc cacgtgcagc cgcgtaccat ctacctgtgc     1140

cggcacggcg agaacgagca caacctccag ggccgcatcg ggggcgactc aggcctgtcc     1200

agccggggca agaagtttgc cagtgctctg agcaagttcg tggaggagca gaacctgaag     1260

gacctgcgcg tgtggaccag ccagctgaag agcaccatcc agacggccga ggcgctgcgg     1320

ctgccctacg agcagtggaa ggcgctcaat gagatcgacg cgggcgtctg tgaggagctg     1380

acctacgagg agatcaggga cacctaccct gaggagtatg cgctgcggga gcaggacaag     1440

tactattacc gctaccccac cggggagtcc taccaggacc tggtccagcg cttggagcca     1500

gtgatcatgg agctggagcg gcaggagaat gtgctggtca tctgccacca ggccgtcctg     1560

cgctgcctgc ttgcctactt cctggataag agtgcagagg agatgcccta cctgaaatgc     1620

cctcttcaca ccgtcctgaa actgacgcct gtcgcttatg gctgccgtgt ggaatccatc     1680

tacctgaacg tggagtccgt ctgcacacac cgggagaggt cagaggatgc aaagaaggga     1740

cctaacccgc tcatgagacg caatagtgtc accccgctag ccagccccga acccaccaaa     1800

aagcctcgca tcaacagctt tgaggagcat gtggcctcca cctcggccgc cctgcccagc     1860

tgcctgcccc cggaggtgcc cacgcagctg cctggacaaa acatgaaagg ctcccggagc     1920

agcgctgact cctccaggaa acactgaggc agacgtgtcg gttccattcc atttccattt     1980

ctgcagctta gcttgtgtcc tgccctccgc ccgaggcaaa acgtatcctg aggacttctt     2040

ccggagaggg tggggtggag cagcggggga gccttggccg aagagaacca tgcttggcac     2100

cgtctgtgtc ccctcggccg ctggacacca gaaagccacg tgggtccctg gcgccctgcc     2160

tttagccgtg gggcccccac ctccactctc tgggtttcct aggaatgtcc agcctcggag     2220

accttcacaa agccttggga gggtgatgag tgctggtcct gacaggaggc cgctggggac     2280

actgtgctgt tttgtttcgt ttctgtgatc tcccggcacg tttggagctg ggaagaccac     2340

actggtggca gaatcctaaa attaaaggag gcaggctcct agttgctgaa agttaaggaa     2400

tgtgtaaaac ctccacgtga ctgtttggtg catcttgacc tgggaagacg cctcatggga     2460

acgaacttgg acaggtgttg ggttgaggcc tcttctgcag gaagtccctg agctgagacg     2520

caagttggct gggtggtccg caccctggct ctcctgcagg tccacacacc ttccaggcct     2580

gtggcctgcc tccaaagatg tgcaagggca ggctggctgc acggggagag ggaagtattt     2640

tgccgaaata tgagaactgg ggcctcctgc tcccagggag ctccagggcc cctctctcct     2700

cccacctgga cttgggggga actgagaaac actttcctgg agctgctggc ttttgcactt     2760

ttttgatggc agaagtgtga cctgagagtc ccaccttctc ttcaggaacg tagatgttgg     2820

ggtgtcttgc cctggggggc ttggaacctc tgaaggtggg gagcggaaca cctggcatcc     2880

ttccccagca cttgcattac cgtccctgct cttcccaggt ggggacagtg gcccaagcaa     2940

ggcctcactc gcagccactt cttcaagagc tgcctgcaca ctgtcttgga gcatctgcct     3000

tgtgcctggc actctgccgg tgccttggga aggtcggaag agtggacttt gtcctggcct     3060

tcccttcatg gcgtctatga cacttttgtg gtgatggaaa gcatgggacc tgtcgtctca     3120

gcctgttggt ttctcctcat tgcctcaaac cctggggtag gtgggacggg gggtctcgtg     3180

cccagatgaa accatttgga aactcggcag cagagtttgt ccaaatgacc cttttcagga     3240

tgtctcaaag cttgtgccaa aggtcacttt tctttcctgc cttctgctgt gagccctgag     3300

atcctcctcc cagctcaagg gacaggtcct gggtgagggt gggagattta gacacctgaa     3360

actgggcgtg gagagaagag ccgttgctgt ttgttttttg ggaagagctt ttaaagaatg     3420

catgtttttt tcctggttgg aattgagtag gaactgaggc tgtgcttcag gtatggtaca     3480

atcaagtggg ggattttcat gctgaaccat tcaagccctc cccgcccgtt gcacccactt     3540

tggctggcgt ctgctggaga ggatgtctct gtccgcattc ccgtgcagct ccaggctcgc     3600

gcagttttct ctctctccct ggatgttgag tctcatcaga atatgtgggt agggggtgga     3660

cgtgcacggg tgcatgattg tgcttaactt ggttgtattt ttcgatttga catggaaggc     3720

ctgttgcttt gctcttgaga atagtttctc gtgtccccct cgcaggcctc attctttgaa     3780

catcgactct gaagtttgat acagataggg gcttgatagc tgtggtcccc tctcccctct     3840

gactacctaa aatcaatacc taaatacaga agccttggtc taacacggga cttttagttt     3900

gcgaagggcc tagataggga gagaggtaac atgaatctgg acagggaggg agatactata     3960

gaaaggagaa cactgcctac tttgcaagcc agtgacctgc cttttgaggg gacattggac     4020

gggggccggg ggcgggggtt gggtttgagc tacagtcatg aacttttggc gtctactgat     4080

tcctccaact ctccacccca caaaataacg gggaccaata tttttaactt tgcctatttg     4140

tttttgggtg agtttccccc ctccttattc tgtcctgaga ccacgggcaa agctcttcat     4200

tttgagagag aagaaaaact gtttggaacc acaccaatga tatttttctt tgtaatactt     4260

gaaatttatt tttttattat tttgatagca gatgtgctat ttatttattt aatatgtata     4320

aggagcctaa acaatagaaa gctgtagaga ttgggtttca ttgttaattg gtttgggagc     4380

ctcctatgtg tgacttatga cttctctgtg ttctgtgtat ttgtctgaat taatgacctg     4440

ggatataaag ctatgctagc tttcaaacag gagatgcctt tcagaaattt gtatattttg     4500

cagttgccag accaataaaa tacctggttg aaatacatgg acgaagtaaa aaa            4553


<210>  765
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  765

Met Pro Leu Glu Leu Thr Gln Ser Arg Val Gln Lys Ile Trp Val Pro 
1               5                   10                  15      


Val Asp His Arg Pro Ser Leu Pro Arg Ser Cys Gly Pro Lys Leu Thr 
            20                  25                  30          


Asn Ser Pro Thr Val Ile Val Met Val Gly Leu Pro Ala Arg Gly Lys 
        35                  40                  45              


Thr Tyr Ile Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp Ile Gly Val 
    50                  55                  60                  


Pro Thr Lys Val Phe Asn Val Gly Glu Tyr Arg Arg Glu Ala Val Lys 
65                  70                  75                  80  


Gln Tyr Ser Ser Tyr Asn Phe Phe Arg Pro Asp Asn Glu Glu Ala Met 
                85                  90                  95      


Lys Val Arg Lys Gln Cys Ala Leu Ala Ala Leu Arg Asp Val Lys Ser 
            100                 105                 110         


Tyr Leu Ala Lys Glu Gly Gly Gln Ile Ala Val Phe Asp Ala Thr Asn 
        115                 120                 125             


Thr Thr Arg Glu Arg Arg His Met Ile Leu His Phe Ala Lys Glu Asn 
    130                 135                 140                 


Asp Phe Lys Ala Phe Phe Ile Glu Ser Val Cys Asp Asp Pro Thr Val 
145                 150                 155                 160 


Val Ala Ser Asn Ile Met Glu Val Lys Ile Ser Ser Pro Asp Tyr Lys 
                165                 170                 175     


Asp Cys Asn Ser Ala Glu Ala Met Asp Asp Phe Met Lys Arg Ile Ser 
            180                 185                 190         


Cys Tyr Glu Ala Ser Tyr Gln Pro Leu Asp Pro Asp Lys Cys Asp Arg 
        195                 200                 205             


Asp Leu Ser Leu Ile Lys Val Ile Asp Val Gly Arg Arg Phe Leu Val 
    210                 215                 220                 


Asn Arg Val Gln Asp His Ile Gln Ser Arg Ile Val Tyr Tyr Leu Met 
225                 230                 235                 240 


Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg His Gly Glu 
                245                 250                 255     


Asn Glu His Asn Leu Gln Gly Arg Ile Gly Gly Asp Ser Gly Leu Ser 
            260                 265                 270         


Ser Arg Gly Lys Lys Phe Ala Ser Ala Leu Ser Lys Phe Val Glu Glu 
        275                 280                 285             


Gln Asn Leu Lys Asp Leu Arg Val Trp Thr Ser Gln Leu Lys Ser Thr 
    290                 295                 300                 


Ile Gln Thr Ala Glu Ala Leu Arg Leu Pro Tyr Glu Gln Trp Lys Ala 
305                 310                 315                 320 


Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Leu Thr Tyr Glu Glu 
                325                 330                 335     


Ile Arg Asp Thr Tyr Pro Glu Glu Tyr Ala Leu Arg Glu Gln Asp Lys 
            340                 345                 350         


Tyr Tyr Tyr Arg Tyr Pro Thr Gly Glu Ser Tyr Gln Asp Leu Val Gln 
        355                 360                 365             


Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Glu Asn Val Leu 
    370                 375                 380                 


Val Ile Cys His Gln Ala Val Leu Arg Cys Leu Leu Ala Tyr Phe Leu 
385                 390                 395                 400 


Asp Lys Ser Ala Glu Glu Met Pro Tyr Leu Lys Cys Pro Leu His Thr 
                405                 410                 415     


Val Leu Lys Leu Thr Pro Val Ala Tyr Gly Cys Arg Val Glu Ser Ile 
            420                 425                 430         


Tyr Leu Asn Val Glu Ser Val Cys Thr His Arg Glu Arg Ser Glu Asp 
        435                 440                 445             


Ala Lys Lys Gly Pro Asn Pro Leu Met Arg Arg Asn Ser Val Thr Pro 
    450                 455                 460                 


Leu Ala Ser Pro Glu Pro Thr Lys Lys Pro Arg Ile Asn Ser Phe Glu 
465                 470                 475                 480 


Glu His Val Ala Ser Thr Ser Ala Ala Leu Pro Ser Cys Leu Pro Pro 
                485                 490                 495     


Glu Val Pro Thr Gln Leu Pro Gly Gln Asn Met Lys Gly Ser Arg Ser 
            500                 505                 510         


Ser Ala Asp Ser Ser Arg Lys His 
        515                 520 


<210>  766
<211>  2493
<212>  DNA
<213>  Homo Sapiens

<400>  766
ccctccgggc aggggaggta ggcctgggcc tgacgccggc cacgcagcgg cgggagagtg       60

agcactcggg cggcggcgtc ctggagaccc gcgagagatg gaagcggcgg cgacgccggc      120

ggctgccggg gcggcgaggc gcgaggagct agatatggat gtaatgaggc ccttgataaa      180

tgagcagaat tttgatggga catcagatga agaacatgag caagagcttc tgcctgttca      240

gaagcattac caacttgatg atcaagaggg catttcattt gtacaaactc ttatgcacct      300

tcttaaagga aatattggaa ctggcctttt aggacttcca ttggcaataa aaaatgcagg      360

catagtgctt ggaccaatca gccttgtgtt tataggaatt atttctgttc actgtatgca      420

catattggta cgttgcagtc actttctatg tctgaggttt aaaaagtcaa cattaggtta      480

tagtgacact gtgagctttg ctatggaagt gagtccttgg agttgtcttc agaagcaagc      540

agcatggggg cggagtgtgg ttgacttttt tctggtgata acacagctgg gattctgtag      600

tgtttatatt gtcttcttag ctgaaaatgt gaaacaagtt catgaaggat tcctggagag      660

taaagtgttt atttcaaata gtaccaattc atcaaaccct tgtgagagaa gaagtgttga      720

cctaaggata tatatgcttt gctttcttcc atttataatt cttttggtct tcattcgtga      780

actaaagaat ctatttgtac tttcattcct tgccaacgtt tccatggctg tcagtcttgt      840

gataatttac cagtatgttg tcaggaacat gccagatccc cacaaccttc caatagtggc      900

tggttggaag aaatacccac tcttttttgg tactgctgta tttgcttttg aaggcatagg      960

agtggtcctt ccactggaaa accaaatgaa agaatcaaag cgtttccctc aagcgttgaa     1020

tattggcatg gggattgtta caactttgta tgtaacatta gctactttag gatatatgtg     1080

tttccatgat gaaatcaaag gcagcataac tttaaatctt ccccaagatg tatggttata     1140

tcaatcagtg aaaattctat attcctttgg catttttgtg acatattcaa ttcagttcta     1200

tgttccagca gagatcatta tccctgggat cacatccaaa tttcatacta aatggaagca     1260

aatctgtgaa tttgggataa gatccttctt ggttagtatt acttgtgccg gagcaattct     1320

tattcctcgt ttagacattg tgatttcctt cgttggagct gtgagcagca gcacattggc     1380

cctaatcctg ccacctttgg ttgaaattct tacattttcg aaggaacatt ataatatatg     1440

gatggtcctg aaaaatattt ctatagcatt cactggagtt gttggcttct tattaggtac     1500

atatataact gttgaagaaa ttatttatcc tactcccaaa gttgtagctg gcactccaca     1560

gagtcctttt ctaaatttga attcaacatg cttaacatct ggtttgaaat agtaaaagca     1620

gaatcatgag tcttctattt ttgtcccatt tctgaaaatt atcaagataa ctagtaaaat     1680

acattgctat atacataaaa atggtaacaa actctgtttt ctttggcacg atattaatat     1740

tttggaagta atcataactc tttaccagta gtggtaaacc tatggaaaat ccttgctttt     1800

aagtgttagc aatagttcaa aaaattaagt tctgaaaatt gaaaaaatta aaatgtaaaa     1860

aaattaaaga ataaaaatac ttctattatt cttttatctc agtaagaaat accttaacca     1920

agttatctct cttttatgct actcttttgc cactcacttg agaacagaat aggatttcaa     1980

caataagaga ataaaataag aacatgtata acaaaaagct ctctccagat catccctgtg     2040

aatgccaaag taaactttat gtacagtgta aaaaaaaaaa atctcagtta tgtttttatt     2100

agccaaattc taatgattgg ctcctggaag tatagaaaac tcccattaac ataatataag     2160

catcagaaaa ttgcaaacac tagaattaat tttacactct aatggtagtt gatcttcata     2220

gtcaagaggc actgttcaag atcatgactt agtgtttcaa tgaaatttga aaagggactt     2280

taaaacttat ccagtgcaac tcccttgttt ttcgtcagag gaaaaggagg cctagaaagg     2340

ttaagtaact tggtcgagac cactcagcct tgagatcaag aaaacctaat cttttgactc     2400

ccaggccagg atgttttatt tctcacatca tgtccaagaa aaagaataaa ttatgttcag     2460

cttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                  2493


<210>  767
<211>  504
<212>  PRT
<213>  Homo Sapiens

<400>  767

Met Glu Ala Ala Ala Thr Pro Ala Ala Ala Gly Ala Ala Arg Arg Glu 
1               5                   10                  15      


Glu Leu Asp Met Asp Val Met Arg Pro Leu Ile Asn Glu Gln Asn Phe 
            20                  25                  30          


Asp Gly Thr Ser Asp Glu Glu His Glu Gln Glu Leu Leu Pro Val Gln 
        35                  40                  45              


Lys His Tyr Gln Leu Asp Asp Gln Glu Gly Ile Ser Phe Val Gln Thr 
    50                  55                  60                  


Leu Met His Leu Leu Lys Gly Asn Ile Gly Thr Gly Leu Leu Gly Leu 
65                  70                  75                  80  


Pro Leu Ala Ile Lys Asn Ala Gly Ile Val Leu Gly Pro Ile Ser Leu 
                85                  90                  95      


Val Phe Ile Gly Ile Ile Ser Val His Cys Met His Ile Leu Val Arg 
            100                 105                 110         


Cys Ser His Phe Leu Cys Leu Arg Phe Lys Lys Ser Thr Leu Gly Tyr 
        115                 120                 125             


Ser Asp Thr Val Ser Phe Ala Met Glu Val Ser Pro Trp Ser Cys Leu 
    130                 135                 140                 


Gln Lys Gln Ala Ala Trp Gly Arg Ser Val Val Asp Phe Phe Leu Val 
145                 150                 155                 160 


Ile Thr Gln Leu Gly Phe Cys Ser Val Tyr Ile Val Phe Leu Ala Glu 
                165                 170                 175     


Asn Val Lys Gln Val His Glu Gly Phe Leu Glu Ser Lys Val Phe Ile 
            180                 185                 190         


Ser Asn Ser Thr Asn Ser Ser Asn Pro Cys Glu Arg Arg Ser Val Asp 
        195                 200                 205             


Leu Arg Ile Tyr Met Leu Cys Phe Leu Pro Phe Ile Ile Leu Leu Val 
    210                 215                 220                 


Phe Ile Arg Glu Leu Lys Asn Leu Phe Val Leu Ser Phe Leu Ala Asn 
225                 230                 235                 240 


Val Ser Met Ala Val Ser Leu Val Ile Ile Tyr Gln Tyr Val Val Arg 
                245                 250                 255     


Asn Met Pro Asp Pro His Asn Leu Pro Ile Val Ala Gly Trp Lys Lys 
            260                 265                 270         


Tyr Pro Leu Phe Phe Gly Thr Ala Val Phe Ala Phe Glu Gly Ile Gly 
        275                 280                 285             


Val Val Leu Pro Leu Glu Asn Gln Met Lys Glu Ser Lys Arg Phe Pro 
    290                 295                 300                 


Gln Ala Leu Asn Ile Gly Met Gly Ile Val Thr Thr Leu Tyr Val Thr 
305                 310                 315                 320 


Leu Ala Thr Leu Gly Tyr Met Cys Phe His Asp Glu Ile Lys Gly Ser 
                325                 330                 335     


Ile Thr Leu Asn Leu Pro Gln Asp Val Trp Leu Tyr Gln Ser Val Lys 
            340                 345                 350         


Ile Leu Tyr Ser Phe Gly Ile Phe Val Thr Tyr Ser Ile Gln Phe Tyr 
        355                 360                 365             


Val Pro Ala Glu Ile Ile Ile Pro Gly Ile Thr Ser Lys Phe His Thr 
    370                 375                 380                 


Lys Trp Lys Gln Ile Cys Glu Phe Gly Ile Arg Ser Phe Leu Val Ser 
385                 390                 395                 400 


Ile Thr Cys Ala Gly Ala Ile Leu Ile Pro Arg Leu Asp Ile Val Ile 
                405                 410                 415     


Ser Phe Val Gly Ala Val Ser Ser Ser Thr Leu Ala Leu Ile Leu Pro 
            420                 425                 430         


Pro Leu Val Glu Ile Leu Thr Phe Ser Lys Glu His Tyr Asn Ile Trp 
        435                 440                 445             


Met Val Leu Lys Asn Ile Ser Ile Ala Phe Thr Gly Val Val Gly Phe 
    450                 455                 460                 


Leu Leu Gly Thr Tyr Ile Thr Val Glu Glu Ile Ile Tyr Pro Thr Pro 
465                 470                 475                 480 


Lys Val Val Ala Gly Thr Pro Gln Ser Pro Phe Leu Asn Leu Asn Ser 
                485                 490                 495     


Thr Cys Leu Thr Ser Gly Leu Lys 
            500                 


<210>  768
<211>  2158
<212>  DNA
<213>  Homo Sapiens

<400>  768
atattctaca tctatcggag ctgaacttcc taaaagacaa agtgtttatc tttcaagatt       60

cattctccct gaatcttacc aacaaaacac tcctgaggag aaagaaagag agggagggag      120

agaaaaagag agagagagaa acaaaaaacc aaagagagag aaaaaatgaa ttcatctaaa      180

tcatctgaaa cacaatgcac agagagagga tgcttctctt cccaaatgtt cttatggact      240

gttgctggga tccccatcct atttctcagt gcctgtttca tcaccagatg tgttgtgaca      300

tttcgcatct ttcaaacctg tgatgagaaa aagtttcagc tacctgagaa tttcacagag      360

ctctcctgct acaattatgg atcaggttca gtcaagaatt gttgtccatt gaactgggaa      420

tattttcaat ccagctgcta cttcttttct actgacacca tttcctgggc gttaagttta      480

aagaactgct cagccatggg ggctcacctg gtggttatca actcacagga ggagcaggaa      540

ttcctttcct acaagaaacc taaaatgaga gagtttttta ttggactgtc agaccaggtt      600

gtcgagggtc agtggcaatg ggtggacggc acacctttga caaagtctct gagcttctgg      660

gatgtagggg agcccaacaa catagctacc ctggaggact gtgccaccat gagagactct      720

tcaaacccaa ggcaaaattg gaatgatgta acctgtttcc tcaattattt tcggatttgt      780

gaaatggtag gaataaatcc tttgaacaaa ggaaaatctc tttaagaaca gaaggcacaa      840

ctcaaatgtg taaagaagga agagcaagaa catggccaca cccaccgccc cacacgagaa      900

atttgtgcgc tgaacttcaa aggacttcat aagtatttgt tactctgata taaataaaaa      960

taagtagttt taaatgttat aattcatgtt actggctgaa gtgcattttc tctctacgtt     1020

agtctcaggt cctcttccca gaatttacaa agcaattcac taccttttgc tacatttgcc     1080

tcatttttta gtgttcgtat gaaagtacag ggacacggag ccaagacaga gtctagcaaa     1140

gaaggggatt ttggaaggtg ccttccaaaa atctcctgaa tccgggctct gtagcaggtc     1200

ctcttctttc tagcttctga caagtctgtc ttctcttctt ggtttcatac cgttcttatc     1260

tcctgcccaa gcatatatcg tctctttact cccctgtata atgagtaaga agcttcttca     1320

agtcatgaaa cttattcctg ctcagaatac cggtgtggcc tttctggcta caggcctcca     1380

ctgcaccttc ttagggaagg gcatgccagc catcagctcc aaacaggctg taaccaagtc     1440

cacccatccc tggggcttcc tttgctctgc cttattttca attgactgaa tggatctcac     1500

cagattttgt atctattgct cagctaggac ccgagtccaa tagtcaattt attctaagcg     1560

aacattcatc tccacacttt cctgtctcaa gcccatccat tatttcttaa cttttatttt     1620

agctttcggg ggtacatgtt aaaggctttt tatataggta aactcatgtc gtggaggttt     1680

gttgtacaga ttatttcatc acccaggtat taagcccagt gcctaatatt gtttttttcg     1740

gctcctctcc ctcctcctac cttccgccct caagtagact ccagtgtctg ttattccctt     1800

ctttgtgttt atgaattctc atcatttagc tcccacttat aagtgaggac atgcagtatt     1860

tggttttctg ttcccatgtt tgctaaggat aatggtttcc agttctaccg atgttcccac     1920

aaaagacata attttctttt ttaaggctgc ttagtattcc atggtatcta tgtatcacat     1980

tttctctatc caatctattg ttgactcaca tttagattga ttccatgttt ttgctattgt     2040

gaatagtgct gcaatgaaca ttcgtgtgca tgtgtcttta tggtagaaag atttatattt     2100

ctctgagtat gtatccagta atagcccatt catttattgc ataaaattct accaatac       2158


<210>  769
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  769

Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Thr Arg Cys Val Val Thr Phe Arg Ile 
        35                  40                  45              


Phe Gln Thr Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Thr 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Thr 
                85                  90                  95      


Asp Thr Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Thr Pro Leu Thr Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Thr Leu 
                165                 170                 175     


Glu Asp Cys Ala Thr Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Thr Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210>  770
<211>  3995
<212>  DNA
<213>  Homo Sapiens

<400>  770
ccccgccccg ctcctctccg gccgcgcagc cgctgccgcc cacccgcacc cgccgtcatg       60

ctccgggccg cgctgcccgc gctcctgctg ccgttgctgg gcctcgccgc tgctgccgtc      120

gcggactgtc cttcatctac ttggattcag ttccaagaca gttgttacat ttttctccaa      180

gaagccatca aagtagaaag catagaggat gtcagaaatc agtgtactga ccatggagcg      240

gacatgataa gcatacataa tgaagaagaa aatgctttta tactggatac tttgaaaaag      300

caatggaaag gcccagatga tatcctacta ggcatgtttt atgacacaga tgatgcgagt      360

ttcaagtggt ttgataattc aaatatgaca tttgataagt ggacagacca agatgatgat      420

gaggatttag ttgacacctg tgcttttctg cacatcaaga caggtgaatg gaaaaaagga      480

aattgtgaag tttcttctgt ggaaggaaca ctatgcaaaa cagctatccc atacaaaagg      540

aaatatttat cagataacca cattttaata tcagcattgg tgattgctag cacggtaatt      600

ttgacagttt tgggagcaat catttggttc ctgtacaaaa aacattctga ttctcgtttc      660

accacagttt tttcaaccgc accccaatca ccttataatg aagactgtgt tttggtagtt      720

ggagaagaaa atgaatatcc tgttcaattt gactaagttt ttggtaatct tgcactaaga      780

catcaacaaa atgccctggc agagataact tgggaaagat tttaatataa aacttgacat      840

tggatattag agctttaatg gtattcctta ttccagtaac atttttatgt actcatctgc      900

tgtgaaaagt ctttaggttc attaaaaaaa caggttttag aaatgatctt agatctaata      960

tagtgatttt aagcatcccg tcaaaggcag aatctgtcac ttgaatgaag gaaagcttaa     1020

agcccaagca gataaaaata aaagcccagc ctatttgtct tgcctgctgt atcttcccta     1080

tttagttgac ccactttagt ttatatgttt attagtaaac atgaaatggg gaataagtga     1140

ttttaagtac atcccataca tttaaatatc tttgataatt gttatttttt tggcagataa     1200

ttcctctaga atgtgtatct ttttatgatt tagatgaaga aaattttaca acttttaaca     1260

ccccacacca attttagttt cattactttt acacacacca ttttatcaca aatgactcaa     1320

gttttaatga atgtttataa attatttgaa acaaaatatg atcgctgtgt ccaggatggc     1380

atagagaaag ctggcaatta ggttaacact tacatattat agtgcccctt taaggatttc     1440

tctcttgcca ccataccttt tgtactttcc cctatacaag atgtatctca ttctcctcaa     1500

gcatttataa atttttcctt caatgacatg aaaactgtgc aagcaaaaac cgaagaaaaa     1560

cacttaagta caactgtagt gacagtgatc aaagttttca gtgcatttat tgtacatttt     1620

aagaaaaagg tgaaaatcat ttggggagta aaaaaatgaa aaagctgaaa cgagtaattt     1680

tcctcaccat caataaacca aaaacaggaa agataaagaa tgtataaatt tcacgtaaat     1740

tagtcacgta tcacttatca atggggatac gttctaagaa atgcatagtt agggaatctt     1800

gtgtgaaaat cagcttgtat ttacacaaac ccagatggta gagcctattt tgtcccaaac     1860

ctacacagca tgttactgtg ctgaatactg cagacaattg taacacaata tttgtgtatc     1920

taaatataga aaaggtacag taaaaatatg gtctactaag gaaacactgt tctatatgtg     1980

gtccattact gactgaagta tactgtctag aagtctgagg ctcaaagaaa agtaatccct     2040

cttctgaatc cacaccccat caattatctt actttcttct ggggagatag atagatatac     2100

tatctcacta gcttgactaa tggcaacaaa gttccagctt gtgtagtctc tttttattga     2160

ccacatgaat cgaaaacact catcacaatt aatggcacta tcattaatga gacatgagta     2220

actaaaaagt gatagaaaac tattaacagt gcggctacat ggtactgaaa atgcaggcat     2280

tacaccagct gttacacaag cacaagcatg ctctgtaaga gctttacatt tctgagattt     2340

tgtatagtga ttgagatgtc tattttatta ttgatagact attactaatg tcaatattga     2400

acactaccct ggaattcctg cctggttttc ctacccaaat tgtaccactc cttgaagaac     2460

tacaggcaca gtaaaaaaaa tatggcgtat tatgtgaact aaaagagttc taaaggagtt     2520

cttaaaggag tggtagaatt tgggtaggaa agtgattaag tccaacttaa aaccaacagt     2580

ctcaaacgtc tacaactaca atgtccaatg agccactagc cacatgaggc tatttaagta     2640

aatttagttt aaaatccagt tttcgaatta cattagccac attgtcaagt gttcaaatca     2700

caggtggtta gtggctactg tactgggcaa catacattat agaacatttt cattatagga     2760

agttttattg ggcagtgctg ctcttaaatc ctaccttcca ctcaactccc atacaacttt     2820

cttttgtaca ttttgatact ttctacctaa tggcagctct tccaaaatag ctgctttaaa     2880

ctctgattta attttcaata tttggtttca tttttcaaca ggccaagagg cctctggtaa     2940

tgaagtgcta tatatatata tatgatggag tctcactgtg ctgcccaggc tacagtgcag     3000

tggctcgatc ttggctctct ccaatctccg ccttgcaggt tttcaagcaa ttctcctgcc     3060

tcagcctcct tagtagctgg gaccacagac atctgtcacc acacccagct aactttttgt     3120

atttttggta gagacggggt ttcgccatat tgactgggct ggtctcaaac tcctgacctc     3180

aagtgatcca cccaccttgg tctcccaaag tgctgggatt acatgcgtga gccaccacac     3240

ttggcctaca ttttttcttt atataccaga acatctataa caggcacctt atctactcat     3300

tagtgaagag ataattggat tacacaggca ggcttgttta ctacatccag aatgtagaaa     3360

ctgctttctt caacatcttg gttctagcta gtaataacaa tataattctt tggcagatat     3420

tcagaataac attttaaact acattttctt agaaaattgc attcttgtag tgagcagtgt     3480

atggtctctt ttgttcagaa tttaaaactg ataaccaatg aaagcctttt ctcttattcc     3540

tctaccgtca tttacatgat aatctgaagc taatatgaca atatttaaat actaagtggt     3600

actagggaac tacaagaata ctgtaaagct taagccattg ttatcactgt catttagcat     3660

ttaataacaa aactatacag aattatgtgc ataccaatga atgttttgta ccatctagtt     3720

aaatttttta aataaagttt tatgggttaa gcagaagaca actgtcatac tgaattttat     3780

taaaagtata tatacttcaa attcaaagca tcccttagga cccacagaat atattaaaac     3840

taccaccctt aaattttata tttttgcttt aagacagaca atgcaaaggt aactggcaag     3900

aggtgagcaa atgttttaga acatttatat tattgcttaa aatgagattt gaaattgtaa     3960

taaaattctt ggttatgaaa aaaaaaaaaa aaaaa                                3995


<210>  771
<211>  232
<212>  PRT
<213>  Homo Sapiens

<400>  771

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Asp Ala Ser Phe Lys Trp Phe Asp Asn Ser Asn Met Thr Phe 
            100                 105                 110         


Asp Lys Trp Thr Asp Gln Asp Asp Asp Glu Asp Leu Val Asp Thr Cys 
        115                 120                 125             


Ala Phe Leu His Ile Lys Thr Gly Glu Trp Lys Lys Gly Asn Cys Glu 
    130                 135                 140                 


Val Ser Ser Val Glu Gly Thr Leu Cys Lys Thr Ala Ile Pro Tyr Lys 
145                 150                 155                 160 


Arg Lys Tyr Leu Ser Asp Asn His Ile Leu Ile Ser Ala Leu Val Ile 
                165                 170                 175     


Ala Ser Thr Val Ile Leu Thr Val Leu Gly Ala Ile Ile Trp Phe Leu 
            180                 185                 190         


Tyr Lys Lys His Ser Asp Ser Arg Phe Thr Thr Val Phe Ser Thr Ala 
        195                 200                 205             


Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val Leu Val Val Gly Glu Glu 
    210                 215                 220                 


Asn Glu Tyr Pro Val Gln Phe Asp 
225                 230         


<210>  772
<211>  2005
<212>  DNA
<213>  Homo Sapiens

<400>  772
caacggctca ttctgctccc ccgggtcgga gccccccgga gctgcgcgcg ggcttgcagc       60

gcctcgcccg cgctgtcctc ccggtgtccc gcttctccgc gccccagccg ccggctgcca      120

gcttttcggg gccccgagtc gcacccagcg aagagagcgg gcccgggaca agctcgaact      180

ccggccgcct cgcccttccc cggctccgct ccctctgccc cctcggggtc gcgcgcccac      240

gatgctgcag ggccctggct cgctgctgct gctcttcctc gcctcgcact gctgcctggg      300

ctcggcgcgc gggctcttcc tctttggcca gcccgacttc tcctacaagc gcagcaattg      360

caagcccatc cctgccaacc tgcagctgtg ccacggcatc gaataccaga acatgcggct      420

gcccaacctg ctgggccacg agaccatgaa ggaggtgctg gagcaggccg gcgcttggat      480

cccgctggtc atgaagcagt gccacccgga caccaagaag ttcctgtgct cgctcttcgc      540

ccccgtctgc ctcgatgacc tagacgagac catccagcca tgccactcgc tctgcgtgca      600

ggtgaaggac cgctgcgccc cggtcatgtc cgccttcggc ttcccctggc ccgacatgct      660

tgagtgcgac cgtttccccc aggacaacga cctttgcatc cccctcgcta gcagcgacca      720

cctcctgcca gccaccgagg aagctccaaa ggtatgtgaa gcctgcaaaa ataaaaatga      780

tgatgacaac gacataatgg aaacgctttg taaaaatgat tttgcactga aaataaaagt      840

gaaggagata acctacatca accgagatac caaaatcatc ctggagacca agagcaagac      900

catttacaag ctgaacggtg tgtccgaaag ggacctgaag aaatcggtgc tgtggctcaa      960

agacagcttg cagtgcacct gtgaggagat gaacgacatc aacgcgccct atctggtcat     1020

gggacagaaa cagggtgggg agctggtgat cacctcggtg aagcggtggc agaaggggca     1080

gagagagttc aagcgcatct cccgcagcat ccgcaagctg cagtgctagt cccggcatcc     1140

tgatggctcc gacaggcctg ctccagagca cggctgacca tttctgctcc gggatctcag     1200

ctcccgttcc ccaagcacac tcctagctgc tccagtctca gcctgggcag cttccccctg     1260

ccttttgcac gtttgcatcc ccagcatttc ctgagttata aggccacagg agtggatagc     1320

tgttttcacc taaaggaaaa gcccacccga atcttgtaga aatattcaaa ctaataaaat     1380

catgaatatt tttatgaagt ttaaaaatag ctcactttaa agctagtttt gaataggtgc     1440

aactgtgact tgggtctggt tggttgttgt ttgttgtttt gagtcagctg attttcactt     1500

cccactgagg ttgtcataac atgcaaattg cttcaatttt ctctgtggcc caaacttgtg     1560

ggtcacaaac cctgttgaga taaagctggc tgttatctca acatcttcat cagctccaga     1620

ctgagactca gtgtctaagt cttacaacaa ttcatcattt tataccttca atgggaactt     1680

aaactgttac atgtatcaca ttccagctac aatacttcca tttattagaa gcacattaac     1740

catttctata gcatgatttc ttcaagtaaa aggcaaaaga tataaatttt ataattgact     1800

tgagtacttt aagccttgtt taaaacattt cttacttaac ttttgcaaat taaacccatt     1860

gtagcttacc tgtaatatac atagtagttt acctttaaaa gttgtaaaaa tattgcttta     1920

accaacactg taaatatttc agataaacat tatattcttg tatataaact ttacatcctg     1980

ttttacctat aaaaaaaaaa aaaaa                                           2005


<210>  773
<211>  295
<212>  PRT
<213>  Homo Sapiens

<400>  773

Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser His 
1               5                   10                  15      


Cys Cys Leu Gly Ser Ala Arg Gly Leu Phe Leu Phe Gly Gln Pro Asp 
            20                  25                  30          


Phe Ser Tyr Lys Arg Ser Asn Cys Lys Pro Ile Pro Ala Asn Leu Gln 
        35                  40                  45              


Leu Cys His Gly Ile Glu Tyr Gln Asn Met Arg Leu Pro Asn Leu Leu 
    50                  55                  60                  


Gly His Glu Thr Met Lys Glu Val Leu Glu Gln Ala Gly Ala Trp Ile 
65                  70                  75                  80  


Pro Leu Val Met Lys Gln Cys His Pro Asp Thr Lys Lys Phe Leu Cys 
                85                  90                  95      


Ser Leu Phe Ala Pro Val Cys Leu Asp Asp Leu Asp Glu Thr Ile Gln 
            100                 105                 110         


Pro Cys His Ser Leu Cys Val Gln Val Lys Asp Arg Cys Ala Pro Val 
        115                 120                 125             


Met Ser Ala Phe Gly Phe Pro Trp Pro Asp Met Leu Glu Cys Asp Arg 
    130                 135                 140                 


Phe Pro Gln Asp Asn Asp Leu Cys Ile Pro Leu Ala Ser Ser Asp His 
145                 150                 155                 160 


Leu Leu Pro Ala Thr Glu Glu Ala Pro Lys Val Cys Glu Ala Cys Lys 
                165                 170                 175     


Asn Lys Asn Asp Asp Asp Asn Asp Ile Met Glu Thr Leu Cys Lys Asn 
            180                 185                 190         


Asp Phe Ala Leu Lys Ile Lys Val Lys Glu Ile Thr Tyr Ile Asn Arg 
        195                 200                 205             


Asp Thr Lys Ile Ile Leu Glu Thr Lys Ser Lys Thr Ile Tyr Lys Leu 
    210                 215                 220                 


Asn Gly Val Ser Glu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys 
225                 230                 235                 240 


Asp Ser Leu Gln Cys Thr Cys Glu Glu Met Asn Asp Ile Asn Ala Pro 
                245                 250                 255     


Tyr Leu Val Met Gly Gln Lys Gln Gly Gly Glu Leu Val Ile Thr Ser 
            260                 265                 270         


Val Lys Arg Trp Gln Lys Gly Gln Arg Glu Phe Lys Arg Ile Ser Arg 
        275                 280                 285             


Ser Ile Arg Lys Leu Gln Cys 
    290                 295 


<210>  774
<211>  1409
<212>  DNA
<213>  Homo Sapiens

<400>  774
cgacttcctc tttccagtgc atttaaggcg cagcctggaa gtgccaggga gcactggagg       60

ccacccagtc atgggggaca ccttcatccg tcacatcgcc ctgctgggct ttgagaagcg      120

cttcgtaccc agccagcact atgtgtacat gttcctggtg aaatggcagg acctgtcgga      180

gaaggtggtc taccggcgct tcaccgagat ctacgagttc cataaaacct taaaagaaat      240

gttccctatt gaggcagggg cgatcaatcc agagaacagg atcatccccc acctcccagc      300

tcccaagtgg tttgacgggc agcgggccgc cgagaaccgc cagggcacac ttaccgagta      360

ctgcggcacg ctcatgagcc tgcccaccaa gatctcccgc tgtccccacc tcctcgactt      420

cttcaaggtg cgccctgatg acctcaagct ccccacggac aaccagacaa aaaagccaga      480

gacatacttg atgcccaaag atggcaagag taccgcgaca gacatcaccg gccccatcat      540

cctgcagacg taccgcgcca ttgccaacta cgagaagacc tcgggctccg agatggctct      600

gtccacgggg gacgtggtgg aggtcgtaga gaagagcgag agcggttggt ggttctgtca      660

gatgaaagca aagcgaggct ggatcccagc gtccttcctc gagcccctgg acagtcctga      720

cgagacggaa gaccctgagc ccaactatgc aggtgagcca tacgtcgcca tcaaggccta      780

cactgctgtg gagggggacg aggtgtccct gctcgagggt gaagctgttg aggtcattca      840

caagctcctg gacggctggt gggtcatcag gaaagacgac gtcacaggct acttcccgtc      900

catgtacctg caaaagtcag ggcaagacgt gtcccaggcc caacgccaga tcaagcgggg      960

ggcgccgccc cgcaggtcgt ccatccgcaa cgcgcacagc atccaccagc ggtcgcggaa     1020

gcgcctcagc caggacgcct atcgccgcaa cagcgtccgt tttctgcagc agcgacgccg     1080

ccaggcgcgg ccgggaccgc agagccccgg gagcccgctc gaggaggagc ggcagacgca     1140

gcgctctaaa ccgcagccgg cggtgccccc gcggccgagc gccgacctca tcctgaaccg     1200

ctgcagcgag agcaccaagc ggaagctggc gtctgccgtc tgaggctgga gcgcagtccc     1260

cagctagcgt ctcggccctt gccgccccgt gcctgtacat acgtgttcta tagagcctgg     1320

cgtctggacg ccgagggcag ccccgacccc tgtccagcgc ggctcccgcc accctcaata     1380

aatgttgctt ggagtggaaa aaaaaaaaa                                       1409


<210>  775
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  775

Met Gly Asp Thr Phe Ile Arg His Ile Ala Leu Leu Gly Phe Glu Lys 
1               5                   10                  15      


Arg Phe Val Pro Ser Gln His Tyr Val Tyr Met Phe Leu Val Lys Trp 
            20                  25                  30          


Gln Asp Leu Ser Glu Lys Val Val Tyr Arg Arg Phe Thr Glu Ile Tyr 
        35                  40                  45              


Glu Phe His Lys Thr Leu Lys Glu Met Phe Pro Ile Glu Ala Gly Ala 
    50                  55                  60                  


Ile Asn Pro Glu Asn Arg Ile Ile Pro His Leu Pro Ala Pro Lys Trp 
65                  70                  75                  80  


Phe Asp Gly Gln Arg Ala Ala Glu Asn Arg Gln Gly Thr Leu Thr Glu 
                85                  90                  95      


Tyr Cys Gly Thr Leu Met Ser Leu Pro Thr Lys Ile Ser Arg Cys Pro 
            100                 105                 110         


His Leu Leu Asp Phe Phe Lys Val Arg Pro Asp Asp Leu Lys Leu Pro 
        115                 120                 125             


Thr Asp Asn Gln Thr Lys Lys Pro Glu Thr Tyr Leu Met Pro Lys Asp 
    130                 135                 140                 


Gly Lys Ser Thr Ala Thr Asp Ile Thr Gly Pro Ile Ile Leu Gln Thr 
145                 150                 155                 160 


Tyr Arg Ala Ile Ala Asn Tyr Glu Lys Thr Ser Gly Ser Glu Met Ala 
                165                 170                 175     


Leu Ser Thr Gly Asp Val Val Glu Val Val Glu Lys Ser Glu Ser Gly 
            180                 185                 190         


Trp Trp Phe Cys Gln Met Lys Ala Lys Arg Gly Trp Ile Pro Ala Ser 
        195                 200                 205             


Phe Leu Glu Pro Leu Asp Ser Pro Asp Glu Thr Glu Asp Pro Glu Pro 
    210                 215                 220                 


Asn Tyr Ala Gly Glu Pro Tyr Val Ala Ile Lys Ala Tyr Thr Ala Val 
225                 230                 235                 240 


Glu Gly Asp Glu Val Ser Leu Leu Glu Gly Glu Ala Val Glu Val Ile 
                245                 250                 255     


His Lys Leu Leu Asp Gly Trp Trp Val Ile Arg Lys Asp Asp Val Thr 
            260                 265                 270         


Gly Tyr Phe Pro Ser Met Tyr Leu Gln Lys Ser Gly Gln Asp Val Ser 
        275                 280                 285             


Gln Ala Gln Arg Gln Ile Lys Arg Gly Ala Pro Pro Arg Arg Ser Ser 
    290                 295                 300                 


Ile Arg Asn Ala His Ser Ile His Gln Arg Ser Arg Lys Arg Leu Ser 
305                 310                 315                 320 


Gln Asp Ala Tyr Arg Arg Asn Ser Val Arg Phe Leu Gln Gln Arg Arg 
                325                 330                 335     


Arg Gln Ala Arg Pro Gly Pro Gln Ser Pro Gly Ser Pro Leu Glu Glu 
            340                 345                 350         


Glu Arg Gln Thr Gln Arg Ser Lys Pro Gln Pro Ala Val Pro Pro Arg 
        355                 360                 365             


Pro Ser Ala Asp Leu Ile Leu Asn Arg Cys Ser Glu Ser Thr Lys Arg 
    370                 375                 380                 


Lys Leu Ala Ser Ala Val 
385                 390 


<210>  776
<211>  1084
<212>  DNA
<213>  Homo Sapiens

<400>  776
aatgagcatc caaaagacgt atctggaggg agattttgtc tttcctgtga gcagcagcag       60

cttcctacgg accctgctgg agccccagct cggatcagcc cttctgacag caatgaatgc      120

ttcgtgctgc ctgccctctg ttcagccaac actgcctaat ggctcggagc acctccaagc      180

ccctttcttc agcaaccaga gcagcagcgc cttctgtgag caggtcttca tcaagcccga      240

ggttttcctg tctctgggca tcgtcagtct gctggaaaac atcctggtta tcctggccgt      300

ggtcaggaac ggcaacctgc actccccgat gtacttcttt ctctgcagcc tggcggtggc      360

cgacatgctg gtaagtgtgt ccaatgccct ggagaccatc atgatcgcca tcgtccacag      420

cgactacctg accttcgagg accagtttat ccagcacatg gacaacatct tcgactccat      480

gatctgcatc tccctggtgg cctccatctg caacctcctg gccatcgccg tcgacaggta      540

cgtcaccatc ttttacgcgc tccgctacca cagcatcatg accgtgagga aggccctcac      600

cttgatcgtg gccatctggg tctgctgcgg cgtctgtggc gtggtgttca tcgtctactc      660

ggagagcaaa atggtcattg tgtgcctcat caccatgttc ttcgccatga tgctcctcat      720

gggcaccctc tacgtgcaca tgttcctctt tgcgcggctg cacgtcaagc gcatagcagc      780

actgccacct gccgacgggg tggccccaca gcaacactca tgcatgaagg gggcagtcac      840

catcaccatt ctcctgggcg tgttcatctt ctgctgggcc cccttcttcc tccacctggt      900

cctcatcatc acctgcccca ccaaccccta ctgcatctgc tacactgccc acttcaacac      960

ctacctggtc ctcatcatgt gcaactccgt catcgaccca ctcatctacg ctttccggag     1020

cctggaattg cgcaacacct ttagggagat tctctgtggc tgcaacggca tgaacttggg     1080

atag                                                                  1084


<210>  777
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  777

Met Asn Ala Ser Cys Cys Leu Pro Ser Val Gln Pro Thr Leu Pro Asn 
1               5                   10                  15      


Gly Ser Glu His Leu Gln Ala Pro Phe Phe Ser Asn Gln Ser Ser Ser 
            20                  25                  30          


Ala Phe Cys Glu Gln Val Phe Ile Lys Pro Glu Val Phe Leu Ser Leu 
        35                  40                  45              


Gly Ile Val Ser Leu Leu Glu Asn Ile Leu Val Ile Leu Ala Val Val 
    50                  55                  60                  


Arg Asn Gly Asn Leu His Ser Pro Met Tyr Phe Phe Leu Cys Ser Leu 
65                  70                  75                  80  


Ala Val Ala Asp Met Leu Val Ser Val Ser Asn Ala Leu Glu Thr Ile 
                85                  90                  95      


Met Ile Ala Ile Val His Ser Asp Tyr Leu Thr Phe Glu Asp Gln Phe 
            100                 105                 110         


Ile Gln His Met Asp Asn Ile Phe Asp Ser Met Ile Cys Ile Ser Leu 
        115                 120                 125             


Val Ala Ser Ile Cys Asn Leu Leu Ala Ile Ala Val Asp Arg Tyr Val 
    130                 135                 140                 


Thr Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Met Thr Val Arg Lys 
145                 150                 155                 160 


Ala Leu Thr Leu Ile Val Ala Ile Trp Val Cys Cys Gly Val Cys Gly 
                165                 170                 175     


Val Val Phe Ile Val Tyr Ser Glu Ser Lys Met Val Ile Val Cys Leu 
            180                 185                 190         


Ile Thr Met Phe Phe Ala Met Met Leu Leu Met Gly Thr Leu Tyr Val 
        195                 200                 205             


His Met Phe Leu Phe Ala Arg Leu His Val Lys Arg Ile Ala Ala Leu 
    210                 215                 220                 


Pro Pro Ala Asp Gly Val Ala Pro Gln Gln His Ser Cys Met Lys Gly 
225                 230                 235                 240 


Ala Val Thr Ile Thr Ile Leu Leu Gly Val Phe Ile Phe Cys Trp Ala 
                245                 250                 255     


Pro Phe Phe Leu His Leu Val Leu Ile Ile Thr Cys Pro Thr Asn Pro 
            260                 265                 270         


Tyr Cys Ile Cys Tyr Thr Ala His Phe Asn Thr Tyr Leu Val Leu Ile 
        275                 280                 285             


Met Cys Asn Ser Val Ile Asp Pro Leu Ile Tyr Ala Phe Arg Ser Leu 
    290                 295                 300                 


Glu Leu Arg Asn Thr Phe Arg Glu Ile Leu Cys Gly Cys Asn Gly Met 
305                 310                 315                 320 


Asn Leu Gly 
            


<210>  778
<211>  2438
<212>  DNA
<213>  Homo Sapiens

<400>  778
ataagccaga gcctagacca gtgagccaac tgtgcgaacc agacccggca gccttgctca       60

gttcagcata gcggagcgga tccgatcgga tcggagcgga tcggagcaca ccggagcagg      120

ctcatcgaga aggcgtctgc gagaccatgg agaacggata cacctatgaa gattataaga      180

acactgcaga atggcttctg tctcacacta agcaccgacc tcaagttgca ataatctgtg      240

gttctggatt aggaggtctg actgataaat taactcaggc ccagatcttt gactacggtg      300

aaatccccaa ctttccccga agtacagtgc caggtcatgc tggccgactg gtgtttgggt      360

tcctgaatgg cagggcctgt gtgatgatgc agggcaggtt ccacatgtat gaagggtacc      420

cactctggaa ggtgacattc ccagtgaggg ttttccacct tctgggtgtg gacaccctgg      480

tagtcaccaa tgcagcagga gggctgaacc ccaagtttga ggttggagat atcatgctga      540

tccgtgacca tatcaaccta cctggtttca gtggtcagaa ccctctcaga gggcccaatg      600

atgaaaggtt tggagatcgt ttccctgcca tgtctgatgc ctacgaccgg actatgaggc      660

agagggctct cagtacctgg aaacaaatgg gggagcaacg tgagctacag gaaggcacct      720

atgtgatggt ggcaggcccc agctttgaga ctgtggcaga atgtcgtgtg ctgcagaagc      780

tgggagcaga cgctgttggc atgagtacag taccagaagt tatcgttgca cggcactgtg      840

gacttcgagt ctttggcttc tcactcatca ctaacaaggt catcatggat tatgaaagcc      900

tggagaaggc caaccatgaa gaagtcttag cagctggcaa acaagctgca cagaaattgg      960

aacagtttgt ctccattctt atggccagca ttccactccc tgacaaagcc agttgacctg     1020

ccttggagtc gtctggcatc tcccacacaa gacccaagta gctgctacct tctttggccc     1080

cttgctggag tcatgtgcct ctgtccttag gttgtagcag aaaggaaaag attcctgtcc     1140

ttcacctttc ccactttctt ctaccagacc cttctggtgc cagatcctct tctcaaagct     1200

gggattacag gtgtgagcat agtgagacct tggcgctaca aaataaagct gttctcattc     1260

ctgttctttc ttacacaaga gctggagccc gtgccctacc acacatctgt ggagatgccc     1320

aggatttgac tcgggcctta gaactttgca tagcagctgc tactagctct ttgagataat     1380

acattccgag gggctcagtt ctgccttatc taaatcacca gagaccaaac aaggactaat     1440

ccaatacctc ttggatttta tttaatgtca taatgttgtc agaataaaga gaaagatgaa     1500

ataatttcat ttttttgtgt aacttggtat ggggctgggg cacagaccaa gattgacatg     1560

aaaggatgtg agatcgcatg tcttgtgtga ctatctgctt ctcagacaag cagttaggaa     1620

ctgagatgag atagtatgtg agggcagcaa aggatgaaga agggcaaaat gatgaaaggt     1680

gaggtggaaa gaggttatga gatggtaaag aaaagttaac ttctggcact tgattgccac     1740

ttctgtcagg ctggtcctgc ctctctccct tgccttctga ttgtttcatt tcctgtttat     1800

ttgatcatat ctgaattagt tcactggtta gcctcttcct tagttcccac ttccttacca     1860

aagccctaat tatatttcct cttgtttgcc ttttctctcc tactcttctc taacatctgc     1920

agccacactc tccattcact ccatgctgac aaggcagtgg caaacacttt tctctgctgc     1980

cagccactcc actgttgact ggattgctgc cagccccagg caaacctgtg aagttgtttc     2040

atactctgct tctctttgag tgcctccttc tctccttcct cttcctttct gggctccagt     2100

ctttctcttc acttgtgctt gtcagaacct ccctgtgata ctgcctccag gcatttcccc     2160

catgttggct caccgcacta ttatctttgc ttatcaactt gcattcagct ggctggcatg     2220

tttcaaaacc acactgccct cccaggcctg tgtgcctttt gagaaagacc agtgctggat     2280

gagcctctag taatgacaac attttagttg ttagtggtat aatacggaag agatattttg     2340

cacaggctgc tttggagaac tttcaaatta tcctttgttt ggtaactgac ctacttaact     2400

gcccaataca aagaaaaagc aaaaaaaaaa aaaaaaaa                             2438


<210>  779
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  779

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  780
<211>  2200
<212>  DNA
<213>  Homo Sapiens

<400>  780
ccgggaccat ggagcctggt gacgcggcgc gccctggctc gggtcgggct accggggcgc       60

cgccgccgcg gctgctgctg ctgccgctgc tgctgggttg ggggctgcga gtcgcggccg      120

cggcctcggc ctcctcctct ggggcggcgg cggaggacag cagcgccatg gaggagctcg      180

ctactgagaa ggaggcggag gagagccacc ggcaagacag cgtgagcctg ctcaccttca      240

tcctgctgct cacgctcacc atcctcacca tctggctctt caagcaccgc cgggtgcgct      300

ttctgcacga gaccgggctg gccatgatct atgggctcat cgttggggtg atcctgaggt      360

atggtacccc tgctaccagt ggccgtgaca aatcactcag ctgcactcag gaagacaggg      420

ccttcagtac cttattagtg aatgtcagcg gaaagttctt cgaatacact ctgaaaggag      480

aaatcagtcc tggcaagatc aacagcgtag agcagaatga tatgctacgg aaggtaacat      540

tcgatccaga agtatttttc aacattcttc tgcctccaat tatttttcat gctggataca      600

gcttaaagaa gagacacttt ttcagaaatc ttggatctat actggcctat gccttcttgg      660

ggactgctgt ttcatgcttc attattggaa atctcatgta tggtgtggtg aagctcatga      720

agattatggg acagctctca gataaatttt actacacaga ttgtctcttt tttggagcaa      780

tcatctctgc cactgaccca gtgactgtgc tggcgatatt taatgaattg catgcagacg      840

tggatcttta cgcacttctt tttggagaga gcgtcctaaa tgatgctgtt gccattgtac      900

tgtcctcgtc tattgttgcc taccagccag cgggactgaa cactcacgcc tttgatgctg      960

ctgccttttt taagtcagtt ggcatttttc taggtatatt tagtggctct tttaccatgg     1020

gagctgtgac tggtgttaat gccaacgtga ctaagtttac caaactgcac tgcttccccc     1080

tgctggagac ggcgctgttc ttcctcatgt cctggagcac gtttctcttg gcagaagcct     1140

gcggatttac aggtgttgta gctgtccttt tctgtggaat cacacaagct cattacacct     1200

acaacaatct gtcggtggaa tcaagaagtc gaaccaagca gctctttgag gtgttacatt     1260

tcctggcaga gaacttcatc ttctcctaca tgggcctggc actgtttacc ttccagaagc     1320

acgttttcag ccccattttc atcatcggag cttttgttgc catcttcctg ggcagagccg     1380

cgcacatcta cccgctctcc ttcttcctca acttgggcag aaggcataag attggctgga     1440

attttcaaca catgatgatg ttttcaggcc tcaggggagc aatggcattt gcgttggcca     1500

tccgtgacac ggcatcctat gctcgccaga tgatgttcac gaccaccctt ctcattgtgt     1560

tcttcactgt ctggatcatt ggaggaggca cgacacccat gttgtcatgg cttaacatca     1620

gagttggcgt cgaggagccc tccgaagagg accagaatga acaccactgg cagtacttca     1680

gagttggtgt tgaccccgat caagacccac cacccaacaa cgacagcttt caagtcttac     1740

aaggggacgg cccagattct gccagaggaa accggacaaa acaggagagc gcatggatat     1800

tcaggctgtg gtacagcttt gatcacaatt acctgaagcc catcctcaca cacagtggtc     1860

ccccactaac caccacgctc cccgcctggt gtggcttact agctcgatgt ctgaccagtc     1920

cccaggtgta cgataaccaa gagccactga gagaggaaga ctctgatttc atcctgaccg     1980

aaggcgacct gacattgacc tacggggaca gcacagtgac tgcaaatggc tcctcaagtt     2040

cgcacaccgc ctccacgagt ctggagggca gccggagaac gaagagcagc tcggaggaag     2100

tgctggagcg agacctggga atgggagacc agaaggtttc gagccggggc acccgcctag     2160

tgtttcccct ggaagataat gcttgacttt ccccccaagc                           2200


<210>  781
<211>  725
<212>  PRT
<213>  Homo Sapiens

<400>  781

Met Glu Pro Gly Asp Ala Ala Arg Pro Gly Ser Gly Arg Ala Thr Gly 
1               5                   10                  15      


Ala Pro Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Gly Trp Gly 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Ala Ser Ala Ser Ser Ser Gly Ala Ala Ala 
        35                  40                  45              


Glu Asp Ser Ser Ala Met Glu Glu Leu Ala Thr Glu Lys Glu Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Val Ser Leu Leu Thr Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Val 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Ile Val 
            100                 105                 110         


Gly Val Ile Leu Arg Tyr Gly Thr Pro Ala Thr Ser Gly Arg Asp Lys 
        115                 120                 125             


Ser Leu Ser Cys Thr Gln Glu Asp Arg Ala Phe Ser Thr Leu Leu Val 
    130                 135                 140                 


Asn Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Gly Glu Ile Ser 
145                 150                 155                 160 


Pro Gly Lys Ile Asn Ser Val Glu Gln Asn Asp Met Leu Arg Lys Val 
                165                 170                 175     


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
            180                 185                 190         


Phe His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Arg Asn Leu 
        195                 200                 205             


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Val Ser Cys Phe 
    210                 215                 220                 


Ile Ile Gly Asn Leu Met Tyr Gly Val Val Lys Leu Met Lys Ile Met 
225                 230                 235                 240 


Gly Gln Leu Ser Asp Lys Phe Tyr Tyr Thr Asp Cys Leu Phe Phe Gly 
                245                 250                 255     


Ala Ile Ile Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe Asn 
            260                 265                 270         


Glu Leu His Ala Asp Val Asp Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
        275                 280                 285             


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
    290                 295                 300                 


Tyr Gln Pro Ala Gly Leu Asn Thr His Ala Phe Asp Ala Ala Ala Phe 
305                 310                 315                 320 


Phe Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr 
                325                 330                 335     


Met Gly Ala Val Thr Gly Val Asn Ala Asn Val Thr Lys Phe Thr Lys 
            340                 345                 350         


Leu His Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu Met Ser 
        355                 360                 365             


Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly Val Val 
    370                 375                 380                 


Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn Asn 
385                 390                 395                 400 


Leu Ser Val Glu Ser Arg Ser Arg Thr Lys Gln Leu Phe Glu Val Leu 
                405                 410                 415     


His Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Ala Leu 
            420                 425                 430         


Phe Thr Phe Gln Lys His Val Phe Ser Pro Ile Phe Ile Ile Gly Ala 
        435                 440                 445             


Phe Val Ala Ile Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu Ser 
    450                 455                 460                 


Phe Phe Leu Asn Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe Gln 
465                 470                 475                 480 


His Met Met Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala Leu 
                485                 490                 495     


Ala Ile Arg Asp Thr Ala Ser Tyr Ala Arg Gln Met Met Phe Thr Thr 
            500                 505                 510         


Thr Leu Leu Ile Val Phe Phe Thr Val Trp Ile Ile Gly Gly Gly Thr 
        515                 520                 525             


Thr Pro Met Leu Ser Trp Leu Asn Ile Arg Val Gly Val Glu Glu Pro 
    530                 535                 540                 


Ser Glu Glu Asp Gln Asn Glu His His Trp Gln Tyr Phe Arg Val Gly 
545                 550                 555                 560 


Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln Val 
                565                 570                 575     


Leu Gln Gly Asp Gly Pro Asp Ser Ala Arg Gly Asn Arg Thr Lys Gln 
            580                 585                 590         


Glu Ser Ala Trp Ile Phe Arg Leu Trp Tyr Ser Phe Asp His Asn Tyr 
        595                 600                 605             


Leu Lys Pro Ile Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr Leu 
    610                 615                 620                 


Pro Ala Trp Cys Gly Leu Leu Ala Arg Cys Leu Thr Ser Pro Gln Val 
625                 630                 635                 640 


Tyr Asp Asn Gln Glu Pro Leu Arg Glu Glu Asp Ser Asp Phe Ile Leu 
                645                 650                 655     


Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr Ala 
            660                 665                 670         


Asn Gly Ser Ser Ser Ser His Thr Ala Ser Thr Ser Leu Glu Gly Ser 
        675                 680                 685             


Arg Arg Thr Lys Ser Ser Ser Glu Glu Val Leu Glu Arg Asp Leu Gly 
    690                 695                 700                 


Met Gly Asp Gln Lys Val Ser Ser Arg Gly Thr Arg Leu Val Phe Pro 
705                 710                 715                 720 


Leu Glu Asp Asn Ala 
                725 


<210>  782
<211>  5903
<212>  DNA
<213>  Homo Sapiens

<400>  782
gggaggcggg aggagagggg gctgccaggg gcgtccggtt acatccccgc cttcctctgt       60

cctggccgcg ggaccgggtt tgcgggaccg cagttcggga acatgttggc ctcgagcagc      120

cggatccggg ctgcgtggac gcgggcgctg ctgctgccgc tgctgctggc ggggcctgtg      180

ggctgcctga gccgccagga gctctttccc ttcggccccg gacaggggga cctggagctg      240

gaggacgggg atgacttcgt ctctcctgcc ctggagctga gtggggcgct ccgcttctac      300

gacagatccg acatcgacgc agtctacgtc accacaaatg gcatcattgc tacgagtgaa      360

cccccggcca aagaatccca tcccgggctc ttcccaccaa cattcggtgc agtcgcccct      420

ttcctggcgg acttggacac gaccgatggc ctggggaagg tttattatcg agaagactta      480

tccccctcca tcactcagcg agcagcagag tgtgtccaca gagggttccc ggagatctct      540

ttccagccta gtagcgcggt ggttgtcact tgggaatccg tggcccccta ccaagggccc      600

agcagggacc cagaccagaa aggcaagaga aacacgttcc aggctgttct agcctcctct      660

gattccagct cctatgccat tttcctttat cctgaggatg gtctgcagtt ccatacgaca      720

ttctcaaaga aggaaaacaa ccaagttcct gccgtggttg cattcagtca aggttcagtg      780

ggattcttat ggaagagcaa cggagcttat aacatatttg ctaatgacag ggaatcagtt      840

gaaaatttgg ccaagagtag taactctggg cagcagggtg tctgggtgtt tgagattggg      900

agtccagcca ccaccaatgg cgtggtgcct gcagacgtga tcctcggaac tgaagatggg      960

gcagagtatg atgatgagga tgaagattat gacctggcga ccactcgtct gggcctggag     1020

gatgtgggca ccacgccctt ctcctacaag gctctgagaa ggggaggtgc tgacacatac     1080

agtgtgccca gcgtcctctc cccgcgccgg gcagctaccg aaaggcccct tggacctccc     1140

acagagagaa ccaggtcttt ccagttggca gtggagactt ttcaccagca gcaccctcag     1200

gtcatagatg tggatgaagt tgaggaaaca ggagttgttt tcagctataa cacggattcc     1260

cgccagacgt gtgctaacaa cagacaccag tgctcggtgc acgcagagtg cagggactac     1320

gccacgggct tctgctgcag ctgtgtcgct ggctatacgg gcaatggcag gcaatgtgtt     1380

gcagaaggtt ccccccagcg agtcaatggc aaggtgaaag gaaggatctt tgtggggagc     1440

agccaggtcc ccattgtctt tgagaacact gacctccact cttacgtagt aatgaaccac     1500

gggcgctcct acacagccat cagcaccatt cccgagaccg ttggatattc tctgcttcca     1560

ctggccccag ttggaggcat cattggatgg atgtttgcag tggagcagga cggattcaag     1620

aatgggttca gcatcaccgg gggtgagttc actcgccagg ctgaggtgac cttcgtgggg     1680

cacccgggca atctggtcat taagcagcgg ttcagcggca tcgatgagca tgggcacctg     1740

accatcgaca cggagctgga gggccgcgtg ccgcagattc cgttcggctc ctccgtgcac     1800

attgagccct acacggagct gtaccactac tccacctcag tgatcacttc ctcctccacc     1860

cgggagtaca cggtgactga gcccgagcga gatggggcat ctccttcacg catctacact     1920

taccagtggc gccagaccat caccttccag gaatgcgtcc acgatgactc ccggccagcc     1980

ctgcccagca cccagcagct ctcggtggac agcgtgttcg tcctgtacaa ccaggaggag     2040

aagatcttgc gctatgctct cagcaactcc attgggcctg tgagggaagg ctcccctgat     2100

gctcttcaga atccctgcta catcggcact catgggtgtg acaccaacgc ggcctgtcgc     2160

cctggtccca ggacacagtt cacctgcgag tgctccatcg gcttccgagg agacgggcga     2220

acctgctatg atattgatga atgttcagaa caaccctcag tgtgtgggag ccacacaatc     2280

tgcaataatc acccaggaac cttccgctgc gagtgtgtgg agggctacca gttttcagat     2340

gagggaacgt gtgtggctgt cgtggaccag cgccccatca actactgtga aactggcctt     2400

cataactgcg acatacccca gcgggcccag tgtatctaca caggaggctc ctcctacacc     2460

tgttcctgct tgccaggctt ttctggggat ggccaagcct gccaagatgt agatgaatgc     2520

cagccaagcc gatgtcaccc tgacgccttc tgctacaaca ctccaggctc tttcacgtgc     2580

cagtgcaaac ctggttatca gggagacggc ttccgttgcg tgcccggaga ggtggagaaa     2640

acccggtgcc agcacgagcg agaacacatt ctcggggcag cgggggcgac agacccacag     2700

cgacccattc ctccggggct gttcgttcct gagtgcgatg cgcacgggca ctacgcgccc     2760

acccagtgcc acggcagcac cggctactgc tggtgcgtgg atcgcgacgg ccgcgaggtg     2820

gagggcacca ggaccaggcc cgggatgacg cccccgtgtc tgagtacagt ggctcccccg     2880

attcaccaag gacctgcggt gcctaccgcc gtgatcccct tgcctcctgg gacccattta     2940

ctctttgccc agactgggaa gattgagcgc ctgcccctgg agggaaatac catgaggaag     3000

acagaagcaa aggcgttcct tcatgtcccg gctaaagtca tcattggact ggcctttgac     3060

tgcgtggaca agatggttta ctggacggac atcactgagc cttccattgg gagagctagt     3120

ctacatggtg gagagccaac caccatcatt agacaagatc ttggaagtcc agaaggtatc     3180

gctgttgatc accttggccg caacatcttc tggacagact ctaacctgga tcgaatagaa     3240

gtggcgaagc tggacggcac gcagcgccgg gtgctctttg agactgactt ggtgaatccc     3300

agaggcattg taacggattc cgtgagaggg aacctttact ggacagactg gaacagagat     3360

aaccccaaga ttgaaacttc ctacatggac ggcacgaacc ggaggatcct tgtgcaggat     3420

gacctgggct tgcccaatgg actgaccttc gatgcgttct catctcagct ctgctgggtg     3480

gatgcaggca ccaatcgggc ggaatgcctg aaccccagtc agcccagcag acgcaaggct     3540

ctcgaagggc tccagtatcc ttttgctgtg acgagctacg ggaagaatct gtatttcaca     3600

gactggaaga tgaattccgt ggttgctctc gatcttgcaa tttccaagga gacggatgct     3660

ttccaacccc acaagcagac ccggctgtat ggcatcacca cggccctgtc tcagtgtccg     3720

caaggccata actactgctc agtgaacaat ggcggctgca cccacctatg cttggccacc     3780

ccagggagca ggacctgccg ttgccctgac aacaccttgg gagttgactg tatcgaacag     3840

aaatgaagac aagagtgcct tatttccttt ccaagtattt cacagcaaca ctctacttga     3900

agcaacttgg tccagattga aaagtgtcct ctggctgagt ggccactagg cccagaccca     3960

gcccagcctg agccccaaca acttttccct cactgttccc caaaacatgc accctggact     4020

tctctaatag aaaagtctcc acccctacac aaggacagaa ccctccaccc ctacccccaa     4080

ccctcagaca gacttataca cccctgagtg aggattacat gcccatccca gtgtcctagg     4140

accttttccc aatactagcc ccccagtggt gaacagaacc tcccaaattt gagttgcacc     4200

cttccctgtg gccttatgag ctcagcctcg ctttgaggta cccaccgtcc tgtcagctcc     4260

ttgacctatg agccggggcc tgactaggaa aagttgggag ttaaggagga aattagcatt     4320

ccttaatgtt ttgttttggt gctctgaatt tcttctttat tatagtccta tagttttact     4380

cctcagttcc tcaccatcat catcttgtct aagaccccca ttataatatt catgcgctgc     4440

tttttcatca aaacctaccc tgtcctagag atctatgggc atttggtgga tgataatgag     4500

cagcccctcc cagatagaat gtcaatattt gagcagtagg atattggcat ttgttagtta     4560

aaggcttaaa tcaaaagaat gtccaatggt aggaatttca aggtgtaggt cagatatttg     4620

agaatagggg atttttttga tgtgccttaa attataccaa agattactaa ttattcctct     4680

ttgcccaaaa tacttgcatc caaggttcta gtctctgttg ctgtgctggt ctttagcccc     4740

actgcttgca ctgatgtccc tccttttcac ggagacctat ctgaggtaca ggatggggct     4800

ggcaccagat gatgtcccac cacagtccct cacctccggc ctccacatga cagaaccaat     4860

ttacactcaa ccatgacctc acccctcctt ggtttctccc tcgatctgtg gccctttttg     4920

gatgtattct tatctaacaa cacaatccgg aaagactgaa ttgaatattt atactaatgg     4980

ttcatatcct ttattgctca atgatctaat taaagggatc attgccacat ttcatgttta     5040

tatttctaca atttgtttag aaaacatctc ctgaccatat cagtagctcg tgttatcttt     5100

ttatcaactg cttcccagag tcctaaaaca atagaaattt tggattgaaa agttcagcat     5160

aaggagtttg agtcagtaaa ggatgggata aaggagtcga gatgattcaa tgaaaagtat     5220

cacaaaaaag agattgatca acaagagaaa taaaaaagcc caagaggaag tggtagggga     5280

aggaatttaa gaacagcaat aagtaaaact cttaagtaac tccaaaaaga aaatggtaca     5340

ttttgccaaa gaccacttat acttgagaac atggaagaat ttgcctgata ctctctttgg     5400

ggaaaagagt ctctcctctt ttcctcaaac cccagtacac tcagcctctc tgccccacct     5460

tctcctgact ttgtcctcac ttgcttctgc agtacattgg aacctgaatt gaaagaaagt     5520

cttccttgaa taattggagt ttgtcttgag aggcaaatat agccccaaga atcacaagat     5580

tcgaggacca tgtaggtctt ttacgtagcc caaatccata aattagtctc actttttgta     5640

tttatcgttt catattaaac cctctatatc aaatgttcat catgattttg tatgattttt     5700

ataactattt tattcatttt attagattta ttctaaaatt ttttaatggt aaattcttaa     5760

actgtggaaa ccactgaagg tgcttattaa ctgttctccc agatttgtac aagtattgga     5820

tgattccttg agtttacagc tgtacaaata gtgtggaaaa taaacttttt ttaaaaaaga     5880

aaaaaaaaaa aaaaaaaaaa aaa                                             5903


<210>  783
<211>  1247
<212>  PRT
<213>  Homo Sapiens

<400>  783

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Val 
705                 710                 715                 720 


Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly Thr Phe Arg Cys 
                725                 730                 735     


Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly Thr Cys Val Ala 
            740                 745                 750         


Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn 
        755                 760                 765             


Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser 
    770                 775                 780                 


Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys 
785                 790                 795                 800 


Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe 
                805                 810                 815     


Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr 
            820                 825                 830         


Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        835                 840                 845             


Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
    850                 855                 860                 


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
865                 870                 875                 880 


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
                885                 890                 895     


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
            900                 905                 910         


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
        915                 920                 925             


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr 
    930                 935                 940                 


His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu 
945                 950                 955                 960 


Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro 
                965                 970                 975     


Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val 
            980                 985                 990         


Tyr Trp Thr Asp Ile Thr Glu Pro  Ser Ile Gly Arg Ala  Ser Leu His 
        995                 1000                 1005             


Gly Gly  Glu Pro Thr Thr Ile  Ile Arg Gln Asp Leu  Gly Ser Pro 
    1010                 1015                 1020             


Glu Gly  Ile Ala Val Asp His  Leu Gly Arg Asn Ile  Phe Trp Thr 
    1025                 1030                 1035             


Asp Ser  Asn Leu Asp Arg Ile  Glu Val Ala Lys Leu  Asp Gly Thr 
    1040                 1045                 1050             


Gln Arg  Arg Val Leu Phe Glu  Thr Asp Leu Val Asn  Pro Arg Gly 
    1055                 1060                 1065             


Ile Val  Thr Asp Ser Val Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1070                 1075                 1080             


Asn Arg  Asp Asn Pro Lys Ile  Glu Thr Ser Tyr Met  Asp Gly Thr 
    1085                 1090                 1095             


Asn Arg  Arg Ile Leu Val Gln  Asp Asp Leu Gly Leu  Pro Asn Gly 
    1100                 1105                 1110             


Leu Thr  Phe Asp Ala Phe Ser  Ser Gln Leu Cys Trp  Val Asp Ala 
    1115                 1120                 1125             


Gly Thr  Asn Arg Ala Glu Cys  Leu Asn Pro Ser Gln  Pro Ser Arg 
    1130                 1135                 1140             


Arg Lys  Ala Leu Glu Gly Leu  Gln Tyr Pro Phe Ala  Val Thr Ser 
    1145                 1150                 1155             


Tyr Gly  Lys Asn Leu Tyr Phe  Thr Asp Trp Lys Met  Asn Ser Val 
    1160                 1165                 1170             


Val Ala  Leu Asp Leu Ala Ile  Ser Lys Glu Thr Asp  Ala Phe Gln 
    1175                 1180                 1185             


Pro His  Lys Gln Thr Arg Leu  Tyr Gly Ile Thr Thr  Ala Leu Ser 
    1190                 1195                 1200             


Gln Cys  Pro Gln Gly His Asn  Tyr Cys Ser Val Asn  Asn Gly Gly 
    1205                 1210                 1215             


Cys Thr  His Leu Cys Leu Ala  Thr Pro Gly Ser Arg  Thr Cys Arg 
    1220                 1225                 1230             


Cys Pro  Asp Asn Thr Leu Gly  Val Asp Cys Ile Glu  Gln Lys 
    1235                 1240                 1245         


<210>  784
<211>  6352
<212>  DNA
<213>  Homo Sapiens

<400>  784
aaagctgtcg cccctctctc ggatgctcag gctgggcagc gctggacaga tgggtacacc       60

ccgggcctga cggatgaaca gtcgggcaag tgaactctca cctccaaact ggctctgcgc      120

ccggcggggg cggcggcggc gtctgcagcc ccgcggtggg ggcagccccc tcggtctacg      180

cccgactgct gcgcgccgcc tctgctcttg gcatagtaat ttcagttcct gaacgcacgg      240

agctcgctcc gggaccgggc tgagaaggac ctcagctcgc gggcccgccg gagccatcgg      300

tgtggcgccg agagacggtg cttgggatat gcgacgggaa gcccccgcca cagcgcaggc      360

agtggccccg ccgcgccgcg gagccgggca gagcaggctg gttcttcaga ggaatcatcc      420

ctgactgtgt catcactctg agctctgact gcgctcccct cccccaccag tgggaccagt      480

actcaagaga gctctggagt gctcctgaag agaaattcca tggggactgt acctgaccct      540

ctgagatcag ctaaaacttc cctgattgca gcttccggaa aagaagacga tctaggagag      600

ccacaggctg cctcacctcg gcatcgacca gctctcctgt gtaagaatgc caatggcttt      660

tcaggtgccc ctgcagaacc agacctcagc cccagggcag ctgccgaagc cctgatgcag      720

gtttgtgagc atgagaccac ccaaccagat atgtcttctc ctggtgtgtt caatgaagtg      780

cagaaagcac ctgccacatt caactctccc ggcaatcccc agctgccagg gagcagccag      840

cccgcagcat cagccccgag ttctgcagca ggaagggatc ttatacacac accattgaca      900

atgcccgcca atcagcacac ctgccagtcc atcccaggtg atcagcccaa tgccatcacc      960

tcatccatgc ctgaagattc cctgatgaga tcacagagaa cctcaaatag agagcaacct     1020

gagaaaccaa gttgtcctgt gggaggcgtc ctcagtagca gcaaagatca ggtgtcctgt     1080

gagtttcctt ctccagaaac aatccaggga acagtgcaga ctccagtgac agcagccagg     1140

gtggtcagtc actcatcctc tcctgtaggt ggacctgaag gggaaaggca gggagccatc     1200

tgtgactctg aaatgaggtc ctgtaaacct ctaactagag aatctggatg ttcagagaac     1260

aagcagccct ctgtcactgc ctcgggcccc caaggcacaa cttctgtgac acctcaacca     1320

acccccctca ctagcgaacc ttcggcatgt cccccaggtc cagagaaggt gccgctgcca     1380

gcacagcgtc agatgtcaag gttcaaagaa gccagtacga tgaccaacca agctgaaagt     1440

gaaatcaagg aagttcccag cagggcttgg caagatgcgg aggtgcaggc agtggcgagt     1500

gtcgagagca gatccgtctc caccagcccc agtatcctca ctgcatttct gaaggaaagc     1560

cgtgctcctg agcattttga acaagagcag ctgcgtgtca tttgccacag cagtgggagc     1620

cacacactgg agctctctga cagcacgcta gccccccagg agtccagcca gtgccctggc     1680

atcatgccac aggtgcacat tcaggcagct gcagctgagt ctacagcttt ccaacgggaa     1740

aataaacttg cgagcctacc aggtggggtc cttaaaacct catcaatcaa tttggtctcc     1800

agtaatgccc agcatacgtg taaagaagat gggaggttag caggaatgac tccagtgagg     1860

gaagagtcaa ctgctaaaaa gctcgcaggt actaattcta gctccctgaa agctaccgcc     1920

attgaccaga tttctatcag tgcatgcagt caagctgaaa caagttatgg attggggaaa     1980

tttgaaacca ggccatctga gtttgcagag aaaacgacaa acggccacaa aacagaccca     2040

gattgcaaac tatctgactc ttgtggctct atcagcaaag ctgatcattc tgggagcttg     2100

gatcccacta ataaaggaga tgcaagggaa aagaagcctg catctcctca ggtagtaaaa     2160

gaaaaagagt ctactggcac tgatacctcg gatgccaaaa ccctactgct caatcctaaa     2220

tcccaagaaa gtggaggcac agaatcagct gctaatccta caccctcccc aattaggaag     2280

aaccaggaga gcaccttaga agaaaacaga cagaccaaga cagccaccag cctgagcctg     2340

ccatctgatc ccatgggtga ctccagccca ggttctggca agaagacccc atctcgctcc     2400

gtcaaagcca gcccacgcag gcccagccgc gtcagcgagt tcctcaagga gcaaaagtta     2460

aatgtgacag cagctgctgc tcaggtagga ctcactccag gagataagaa aaagcagctt     2520

ggcgcagact ccaagctcca gctgaaacag tccaagcgtg tcagggacgt cgtgtgggat     2580

gagcagggaa tgacctggga agtgtatggt gcatccttgg acgcagagtc cctgggaatc     2640

gcgatccaga accatttgca aagacaaatc agggaacatg agaaattaat caaaactcaa     2700

aatagccaga cccggagatc catttcctca gatacttctt caaataagaa gctcagagga     2760

aggcagcaca gtgttttcca gtccatgctg cagaacttcc gacgccccaa ctgctgcgtc     2820

cgtcctgccc cgtcttctgt gttagattga aagggagtat ttatgggagt ttgtgtataa     2880

atttacggta ttcacatgcg tccctctatg tcaaagcttg cttagttttt tgctgcaaga     2940

ctaggaagaa aaagcaagta ttcactatag gaaattgcta ttaaaaattg ttagatcctt     3000

tgacctggag ctctataaac aaaaatgtca tttcaatttg aaagaaggaa caagaaaaga     3060

gaaacaagct tcactgaagg tttgcaacct taacaaattg aaaataatac tcactgggtt     3120

tttaaaaata tgatgttgtt catagaaata gcattattgt atcattatac atgtattatt     3180

ttgtataact gcctcaattt atcacacagt agtagttcca ttaaaatccc tgcttcatat     3240

tgaaagtagc aaaaacacta ttggcgaaaa cattgttata atttctagtc ttattgcagt     3300

aagaatgctg taaccacaca aattataaat aggtgataag aaccataatg aaaaaaatga     3360

gaacatattt gattcattcc taggccagat aacattaaat aaaaacagtt aaatgtgtaa     3420

aatatgaaat atgaattaat gtttataaac atctgcagac aactcttttt ataaaccttc     3480

ttattgctgt taataaatat aagaaagtta tattaggaac attagctaag cttttgacta     3540

tgaaaactgc ctacattaaa catggattta tatagaccca ttttcctgca ctgaaggcaa     3600

ggcgcatctc tgtgattctg accagacata ttcatatttt cttaccctag aggaagtaca     3660

tgggactgaa ttcttgaaaa gagccatcaa attagggata atactaaatt gatactgtgc     3720

aggtgttctc cagtgatatt ctactgagaa tgctaaggtt ctggtcagga actataaata     3780

gcagattacc aaacactgct ttttctgtga tgataaaagc ctcataagta acaaaaacaa     3840

tgtttaattt agactcctgt aaacaggatg caattagtga ttttttttaa ttgggttcag     3900

taacttccag taacaaatgt agtcaacacc aaattagaat gtgagcttcc ttacaatttt     3960

tgtacataga ctactatcat ctaattgctt aaatatatat gctggagtaa aaaggtaact     4020

tctgcaaact tattgatttt aagagaaata cccataatat ccttcaaacc caatgaaaga     4080

agaggccttt acgaaaacat ggcttgtgat ttgggtggat tatacttcct gggaccttgg     4140

ccctcccgtg tctccagaag agacgtgtgt cccgagacac atgagtatcc tccaaggcac     4200

tggcctggat gagcagcatc gccttgagaa ttggggtagt gtggaaagga agaatgaaca     4260

acggccctgg gaagccttcc cttcctgcag atattgttgg gggagtgctg gtctccattt     4320

tgcgtttaga aaaccagact tagatgctgg aggggcaccg gttgtcttct ttgaactcat     4380

tccccgtaat gagctagaaa agagtaccta accataggta ttctctctag agactcatgt     4440

gtcccgtggg tacagtcaat tcacagtatc tgttctggct tttttcactt taattctgtt     4500

ctgcacattc tgaacatatg caggaaaaaa aatcattcct gaacttagca caagctacac     4560

tcgacacaac ctaaattagt aaaaagcctt tgatttattt tgaagcaatt taactgtaga     4620

caaagcttgc atatatggaa cagtattctc agagcctgag agttgttaca gttgttctat     4680

ttggaaatta gaaggaattt tttaataagg cacatttttc agtttcttac ccattggtgt     4740

ctattaagaa tactatgtaa tgttgaaatt tccatcaaat taccaagcaa attactatta     4800

atgattagag atttagccta acactctctc tttgggcctt aaatacccat ttgtagttgt     4860

gttcgtgtca cttctgtctc agatgcctct gccaggacat aatctctcta actcttgcta     4920

gctggcttct ccctcccaca tgggcataca tgctgtgtat acacagagta cagcctgtgt     4980

acacagtagc agctgtcaac agggcctact ccagatgggt ggccccaggt aatcctctgc     5040

tgtaaagtgg ctagaacagg ctgtccctgc attaaaatag gtgagaataa ggaatttcgc     5100

ctctgataat aatatttatt ttcatgactt tagagtaacc acatgatttg taaacagtta     5160

aatgaagcag aggcctgaga gagttgttgg catttgtctc acattaaata cattaaaatt     5220

gctagatttg ctattgtggt tatgtctatc aaaactttaa gaaaatttgt ttaatgtact     5280

gagtttaact gattttcttt ggtgctggga ccaaattctt cacttctaca acactcaaga     5340

gattgtcaca aaatattaca aaaatattgt ttgttttgtg gctcattaaa ccctatataa     5400

ctaacagctt ttaaggacat taacagaaat atatcttcag atggataaat aagataggga     5460

cctattcaag acagcagcat ttttgtattg tgatacctcc cctaagttac tctcacaata     5520

aaaccttatt tgagaatttt ccttcacttc aatctgtgac atagcattag gcatttagta     5580

taccttattt gtgaaaccta aggttcattc aacagatgaa gctgcaaaac agttttcttg     5640

gtagactctt ggaacttgct cagttttttc cttactttac ctgcatgaca cacattgggt     5700

tgaaagttgt ttggttttac ccttcatttc tcttagatat gatttggttc tttttcatgc     5760

attatatttt tgaaatatat ggaggaaata ttttattgaa tcaagaaata gaaaatattc     5820

cttaaaccag tagtaaaaag gtgagttaga actccatgtc tggaagacaa ttcaacattt     5880

aaaatattaa gatgctatac cacttaacaa gtgaatacta aaatttttaa tttaaagatt     5940

gattgttctg tttttatgac catgagaaaa atgtgacagc ttcagctgtc atatgtttat     6000

cttgaatgct tttctaatta tgtatttctg gattattgac tttgaatgcc acagaccaac     6060

tactttacat agagtaaaat attgattaac ctttgtgctt tgggtcactg gcaaaagttg     6120

aacatcctga taagtcaatg ttaaccagaa acctttttgt tcacgtctga aattgaatat     6180

ttataaaatg tgttagtatg tttcctgcct tgataagttc acctatattg aatgtaattt     6240

gatctttgat aatttttttt aatcttgaga attctctgat actgttttga ataccagtgt     6300

tcaccatgtt ataaagttaa acataaaaat tgaaataaat tgaactaaat at             6352


<210>  785
<211>  776
<212>  PRT
<213>  Homo Sapiens

<400>  785

Met Gly Thr Val Pro Asp Pro Leu Arg Ser Ala Lys Thr Ser Leu Ile 
1               5                   10                  15      


Ala Ala Ser Gly Lys Glu Asp Asp Leu Gly Glu Pro Gln Ala Ala Ser 
            20                  25                  30          


Pro Arg His Arg Pro Ala Leu Leu Cys Lys Asn Ala Asn Gly Phe Ser 
        35                  40                  45              


Gly Ala Pro Ala Glu Pro Asp Leu Ser Pro Arg Ala Ala Ala Glu Ala 
    50                  55                  60                  


Leu Met Gln Val Cys Glu His Glu Thr Thr Gln Pro Asp Met Ser Ser 
65                  70                  75                  80  


Pro Gly Val Phe Asn Glu Val Gln Lys Ala Pro Ala Thr Phe Asn Ser 
                85                  90                  95      


Pro Gly Asn Pro Gln Leu Pro Gly Ser Ser Gln Pro Ala Ala Ser Ala 
            100                 105                 110         


Pro Ser Ser Ala Ala Gly Arg Asp Leu Ile His Thr Pro Leu Thr Met 
        115                 120                 125             


Pro Ala Asn Gln His Thr Cys Gln Ser Ile Pro Gly Asp Gln Pro Asn 
    130                 135                 140                 


Ala Ile Thr Ser Ser Met Pro Glu Asp Ser Leu Met Arg Ser Gln Arg 
145                 150                 155                 160 


Thr Ser Asn Arg Glu Gln Pro Glu Lys Pro Ser Cys Pro Val Gly Gly 
                165                 170                 175     


Val Leu Ser Ser Ser Lys Asp Gln Val Ser Cys Glu Phe Pro Ser Pro 
            180                 185                 190         


Glu Thr Ile Gln Gly Thr Val Gln Thr Pro Val Thr Ala Ala Arg Val 
        195                 200                 205             


Val Ser His Ser Ser Ser Pro Val Gly Gly Pro Glu Gly Glu Arg Gln 
    210                 215                 220                 


Gly Ala Ile Cys Asp Ser Glu Met Arg Ser Cys Lys Pro Leu Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Cys Ser Glu Asn Lys Gln Pro Ser Val Thr Ala Ser Gly 
                245                 250                 255     


Pro Gln Gly Thr Thr Ser Val Thr Pro Gln Pro Thr Pro Leu Thr Ser 
            260                 265                 270         


Glu Pro Ser Ala Cys Pro Pro Gly Pro Glu Lys Val Pro Leu Pro Ala 
        275                 280                 285             


Gln Arg Gln Met Ser Arg Phe Lys Glu Ala Ser Thr Met Thr Asn Gln 
    290                 295                 300                 


Ala Glu Ser Glu Ile Lys Glu Val Pro Ser Arg Ala Trp Gln Asp Ala 
305                 310                 315                 320 


Glu Val Gln Ala Val Ala Ser Val Glu Ser Arg Ser Val Ser Thr Ser 
                325                 330                 335     


Pro Ser Ile Leu Thr Ala Phe Leu Lys Glu Ser Arg Ala Pro Glu His 
            340                 345                 350         


Phe Glu Gln Glu Gln Leu Arg Val Ile Cys His Ser Ser Gly Ser His 
        355                 360                 365             


Thr Leu Glu Leu Ser Asp Ser Thr Leu Ala Pro Gln Glu Ser Ser Gln 
    370                 375                 380                 


Cys Pro Gly Ile Met Pro Gln Val His Ile Gln Ala Ala Ala Ala Glu 
385                 390                 395                 400 


Ser Thr Ala Phe Gln Arg Glu Asn Lys Leu Ala Ser Leu Pro Gly Gly 
                405                 410                 415     


Val Leu Lys Thr Ser Ser Ile Asn Leu Val Ser Ser Asn Ala Gln His 
            420                 425                 430         


Thr Cys Lys Glu Asp Gly Arg Leu Ala Gly Met Thr Pro Val Arg Glu 
        435                 440                 445             


Glu Ser Thr Ala Lys Lys Leu Ala Gly Thr Asn Ser Ser Ser Leu Lys 
    450                 455                 460                 


Ala Thr Ala Ile Asp Gln Ile Ser Ile Ser Ala Cys Ser Gln Ala Glu 
465                 470                 475                 480 


Thr Ser Tyr Gly Leu Gly Lys Phe Glu Thr Arg Pro Ser Glu Phe Ala 
                485                 490                 495     


Glu Lys Thr Thr Asn Gly His Lys Thr Asp Pro Asp Cys Lys Leu Ser 
            500                 505                 510         


Asp Ser Cys Gly Ser Ile Ser Lys Ala Asp His Ser Gly Ser Leu Asp 
        515                 520                 525             


Pro Thr Asn Lys Gly Asp Ala Arg Glu Lys Lys Pro Ala Ser Pro Gln 
    530                 535                 540                 


Val Val Lys Glu Lys Glu Ser Thr Gly Thr Asp Thr Ser Asp Ala Lys 
545                 550                 555                 560 


Thr Leu Leu Leu Asn Pro Lys Ser Gln Glu Ser Gly Gly Thr Glu Ser 
                565                 570                 575     


Ala Ala Asn Pro Thr Pro Ser Pro Ile Arg Lys Asn Gln Glu Ser Thr 
            580                 585                 590         


Leu Glu Glu Asn Arg Gln Thr Lys Thr Ala Thr Ser Leu Ser Leu Pro 
        595                 600                 605             


Ser Asp Pro Met Gly Asp Ser Ser Pro Gly Ser Gly Lys Lys Thr Pro 
    610                 615                 620                 


Ser Arg Ser Val Lys Ala Ser Pro Arg Arg Pro Ser Arg Val Ser Glu 
625                 630                 635                 640 


Phe Leu Lys Glu Gln Lys Leu Asn Val Thr Ala Ala Ala Ala Gln Val 
                645                 650                 655     


Gly Leu Thr Pro Gly Asp Lys Lys Lys Gln Leu Gly Ala Asp Ser Lys 
            660                 665                 670         


Leu Gln Leu Lys Gln Ser Lys Arg Val Arg Asp Val Val Trp Asp Glu 
        675                 680                 685             


Gln Gly Met Thr Trp Glu Val Tyr Gly Ala Ser Leu Asp Ala Glu Ser 
    690                 695                 700                 


Leu Gly Ile Ala Ile Gln Asn His Leu Gln Arg Gln Ile Arg Glu His 
705                 710                 715                 720 


Glu Lys Leu Ile Lys Thr Gln Asn Ser Gln Thr Arg Arg Ser Ile Ser 
                725                 730                 735     


Ser Asp Thr Ser Ser Asn Lys Lys Leu Arg Gly Arg Gln His Ser Val 
            740                 745                 750         


Phe Gln Ser Met Leu Gln Asn Phe Arg Arg Pro Asn Cys Cys Val Arg 
        755                 760                 765             


Pro Ala Pro Ser Ser Val Leu Asp 
    770                 775     


<210>  786
<211>  1900
<212>  DNA
<213>  Homo Sapiens

<400>  786
agccgcgggg agcgaggagc gcgcggagcc ggccatgggc aagtcagctt ccaaacagtt       60

tcataatgag gtcctgaagg cccacaatga gtaccggcag aagcacggcg tccccccact      120

gaagctctgc aagaacctca accgggaggc tcaacagtat tctgaggccc tggccagcac      180

gaggatcctc aagcacagcc cggagtccag ccgtggccag tgtggggaga accttgcatg      240

ggcatcctat gatcagacag gaaaggaggt ggctgataga tggtacagtg aaatcaagaa      300

ctataacttc cagcagcctg gcttcacctc ggggactgga cacttcacgg ccatggtatg      360

gaagaacacc aagaagatgg gcgtggggaa ggcgtccgca agtgacgggt cctcctttgt      420

ggtggccaga tacttcccag cggggaatgt tgtcaatgag ggcttcttcg aagaaaacgt      480

cctgccgccg aagaagtaac ttgttaaatg taatgggaag gtggcagact taagaacgtg      540

gatatgaagt gcctagaacc accacaacct ggctgtgcgt ctgtccctgt gggtgtatgt      600

gcttgtgtgt gtgatgcatg tgagcgtctc tggcacacac acttggacat acagttctgt      660

gtgcgctcat tcttattaca ggagtgagca aaggaagcat ttaccccgat ggttacctag      720

accacgatta tttggattgg ggggaggggg gatccgtttt ttttttttaa ttttttgtta      780

tttctaagca aacctctttt gtacttttct tacttctaat atccatccct ggactttttg      840

tattccaaat gtttgtgatg ctgagaagtg aagttcattt tatgtgatct tcatgcgtcg      900

taatctactt ttggtagata attaagatta ttaaaccctc atttaaatgt gacataaaat      960

acagctttaa gcacataaat ataaagcagc ttccatcagg aacatggagc aggcagggac     1020

tccattttac agaattactg agatttctca gttgtaaaac atgatgtcat cctgcatgcc     1080

tcctggaatt ctccaatggg gtcgccaaac aacaaatgga gaaaaaaagt tttacttcct     1140

tgcattcttc tacctttaaa tagcaaagta ccactaccac caccacctct tgcccccttc     1200

cctcttttct taaacttctg gcatttcaga gctcagcagg ctacccctgg tttctggaga     1260

gttgggctag gcctgaagct ccccctcccc cacctctgct aggcagccca ggcctggtct     1320

gggagacagc ccctcaccct gcctgggctc ttggccaagc ggccttggat ggatgaagtc     1380

agagaggtgg ggtgagggtg agcttactca gggcccccag aggaagccct cagcctctgc     1440

cctcccccca cacagggcgg gagcccaggc ctgttcctgg cagctgtggc tgcagctgtg     1500

ctcctgctcc ctcctggaat gtgcgacaag cccaaatgtt ccagggaggc ggccggggca     1560

gggggcttag aagtgctaat atggttctgt gttttgcctg aaacgatacc aggttcccct     1620

gaatagcaac tttacaaggt ccatgtggga gggaccaacc cagatgccct gctgagtgtc     1680

cctgaaacca tggcagctcc atctgtcaag atggcagggg ccggagtgag ggggctgctg     1740

gcttaacagc aggcatctgg gcaggccagt cctcaaagca gctcctgaag gtctgtgttg     1800

cactgtcacc agtctcaagc tatgcctcta atttcaccag ggatattgac taagaagaca     1860

ataaaatctt tttctttgtg taaaaaaaaa aaaaaaaaaa                           1900


<210>  787
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  787

Met Gly Lys Ser Ala Ser Lys Gln Phe His Asn Glu Val Leu Lys Ala 
1               5                   10                  15      


His Asn Glu Tyr Arg Gln Lys His Gly Val Pro Pro Leu Lys Leu Cys 
            20                  25                  30          


Lys Asn Leu Asn Arg Glu Ala Gln Gln Tyr Ser Glu Ala Leu Ala Ser 
        35                  40                  45              


Thr Arg Ile Leu Lys His Ser Pro Glu Ser Ser Arg Gly Gln Cys Gly 
    50                  55                  60                  


Glu Asn Leu Ala Trp Ala Ser Tyr Asp Gln Thr Gly Lys Glu Val Ala 
65                  70                  75                  80  


Asp Arg Trp Tyr Ser Glu Ile Lys Asn Tyr Asn Phe Gln Gln Pro Gly 
                85                  90                  95      


Phe Thr Ser Gly Thr Gly His Phe Thr Ala Met Val Trp Lys Asn Thr 
            100                 105                 110         


Lys Lys Met Gly Val Gly Lys Ala Ser Ala Ser Asp Gly Ser Ser Phe 
        115                 120                 125             


Val Val Ala Arg Tyr Phe Pro Ala Gly Asn Val Val Asn Glu Gly Phe 
    130                 135                 140                 


Phe Glu Glu Asn Val Leu Pro Pro Lys Lys 
145                 150                 


<210>  788
<211>  6972
<212>  DNA
<213>  Homo Sapiens

<400>  788
gagagtccgg ggatcccggg ggccagtcgc ggccgggaca tcgggcgctg cggccgggga       60

cccgctgctg agatagacag aatatggcag agctttctga gccagaggga ccagtagatt      120

ggaaggaacg atgtgtagct ctggagtccc aactcatgaa atttagagtt caagcaagca      180

agatacgaga gcttttagca gagaagatgc aacagcttga gagacaagtt attgatgctg      240

aacgtcaagc agaaaaagct tttcaacagg tacaagttat ggaagataaa ttaaaagcag      300

ctaatattca aaccagtgaa tcagagacaa gattatataa taagtgtcaa gatctggagt      360

cgctaataca ggaaaaagat gacgtcattc aaaacttgga attgcaactt gaagagcaga      420

aacaaataag aatacaagaa gctaaaataa tagaagagaa agcagctaag ataaaagaat      480

gggtaacagt taagttaaat gagctggaat tggagaatca gaatcttcgt ttgatcaacc      540

aaaaccaaac tgaagagata agaacaatgc agtcaaaact acaagaagtt caaggaaaga      600

agtcatccac tgtctctaca ctaaagcttt cggaaggcca gcgcctgagc agtttgacct      660

ttgggtgctt tttatctcga gcaaggagtc ctcctcaagt agtaaaatct gaggaaatga      720

gcaagatatc atcgaaagaa cctgagttca ctgaaggaaa agacatggaa gaaatggaaa      780

ttccagaaaa gtctgttgat aaccaagttc tagaaaacaa cagaggccag agaacattgc      840

atcaaacccc ttgtggctca gaacagaatc ggaaaacaag aacaagcttt gccacagatg      900

gtggcatctc ccagaattct ggggctcctg tgagtgactg gagctctgat gaggaagacg      960

ggagcaaagg aagatccaag tccagatgca catccaccct ctccagtcac acatctgagg     1020

aaggggtcca gtgtagcagg atgggaagtg aaatgtatct gacagcatct gatgacagca     1080

gctctatatt tgaggaagag acttttggca taaagagacc agaacacaag aagctatatt     1140

cttggcagca ggaggcacag tggaaagctc taaatagtcc tcttggaaag ggaaattctg     1200

aattaagtaa aaaggaacaa gatagttcct cggatgaact gaataaaaaa tttcaatccc     1260

agagactcga ttattcatct tcatcgagtg aagccaacac cccaagccct attttgaccc     1320

cagctttaat gccaaagcat cctaactcac tctctggaaa aggaacacaa ttagtgcctt     1380

catcacacct gccaccccca aagttaagga ttcctaatgt tttcagtata agtgtagcac     1440

tagccaaaag gcacttaagc cagccacagt taagctctga caggatgttt ggtacaaata     1500

gaaacgctat aagcatgata cgaccactga gacctcagga aactgatctt gatctagttg     1560

atggagacag tacagaagtt ttagagaata tggacacgag ttgtgatgat ggattatttt     1620

cctatgactc cttggactct ccaaattcag atgaccagga acactgtgac tcagcaaaga     1680

aggtggcata cagcaaacct ccaactcctc ccctgcaccg ttttccttct tgggaaagca     1740

gaatttatgc tgtagccaaa tcaggtattc gaatgtctga ggccttcaat atggagagtg     1800

ttaataaaaa ttctgctgca accctttcct atactacatc aggactttat acatctctga     1860

tatacaagaa catgaccacc ccagtgtata caactttgaa ggggaaggcg acccaaataa     1920

gtagcagccc tttcctggat gactcatctg ggtcagagga agaagacagc tccagatcca     1980

gctcccggac gtcagagtca gactcacgca gtaggagtgg gccaggcagc cccagagcca     2040

tgaaacgagg tgtgtctctc tcctctgtgg cttctgaaag tgattatgct attcctcctg     2100

atgcttactc cacagacacg gagtactcac agccagagca gaagctccca aaaacttgct     2160

catcttccag tgataatggg aaaaatgaac cactggaaaa atctggttat ttattaaaaa     2220

tgagtggtaa agtcaagtct tggaagcggc ggtggtttgt tcttaaaggt ggtgaattac     2280

tttactacaa atctccgagt gatgtaatta gaaaacccca gggccatatt gaacttagtg     2340

catcctgtag tattttaaga ggagataaca aacaaacagt tcagttgacc actgaaaaac     2400

acacatacta tctgactgca gattctccca atatattgga agagtggatt aaagtgttac     2460

agaatgttct tcgagtacaa gctgccaacc cactttccct gcagcctgag ggcaaaccca     2520

ccatgaaggg attgctcact aaggtaaaac atggatattc caagagagtc tggtgtacac     2580

taataggaaa gacattatat tattttcgga gtcaagaaga taagtttcct ttaggtcaga     2640

tcaaactctg ggaggctaaa gtggaagagg ttgacagatc ttgtgattca gatgaagatt     2700

atgaagccag tggacgaagt ctgttatcca cacattatac tatcgttatc catcccaaag     2760

accaaggtcc aacttacctc ctaattggat ccaagcatga aaaggacact tggctttatc     2820

atctgactgt tgcagctgga agcaacaatg taaacgttgg atctgaattt gaacaactgg     2880

tttgcaaatt gctaaatata gacggggagc cttcctctca gatatggaga caccccactt     2940

tgtgtcacag taaagaagga atcatttccc ctctgacaac tctaccttcc gaagccctgc     3000

agacagaagc tattaaatta tttaagacct gccagctttt tataaatgct gcagttgact     3060

ctcctgcaat tgattaccac atatctttag cccagagtgc tttgcaaatc tgcctgacac     3120

atcctgagct gcagaatgaa atttgctgtc agcttattaa acagacaaga cgaagacagc     3180

cacagaatca accaggacca ttgcagggct ggcagctctt ggcactctgc gttgggctct     3240

tccttcccca tcatcctttc ctgtggctcc tcaggcttca cctaaagagg aatgcagatt     3300

ccaggacaga atttggaaaa tatgccattt actgccagcg ttgtgtagaa agaacgcaac     3360

aaaatggtga cagagaagca agaccctcaa ggatggaaat tctttcaact cttctccgaa     3420

acccttatca ccattctttg ccctttagta tacctgtgca cttcatgaat gggatatacc     3480

aggtagttgg ttttgacgca tctaccacag tggaagaatt tttgaatact ttgaaccagg     3540

acacaggaat gaggaaacca gcgcagtctg gatttgcgtt gttcactgac gatccttctg     3600

gcagagattt agagcattgt cttcaaggaa acatcaagat ttgtgacatt atttccaaat     3660

gggaacaggc ttccaaagaa cagcagcctg gaaaatgtga aggtacaagg actgttcgtc     3720

tgacatacaa aaacagacta tatttctcag tgcaagctcg tggagagact gatagagaaa     3780

agttgctgtt aatgtatcag acaaatgatc aaatcataaa tggacttttt cctctgaaca     3840

aagatctggc attagaaatg gcagctcttt tatctcaggt agagattgga gattttgaaa     3900

gacctttctc aactccagca gggcatgtta ccaatcagtg caaagtgaat caaactctaa     3960

agcaagtcat agagaaattt tatcctaaaa ggtatagaga tggctgttct gaagagcagt     4020

taaggcagct ttgccagcga ctttcaacca gatggatggc cctccgggga cacagtgctg     4080

ctgactgtgt gcgcatttat ttgacagtag ccaggaagtg gccattcttt ggtgccaagt     4140

tgtttcttgc aaaacccata actccatcat cacttggaag tactttcttg tggctggctg     4200

tacatgagga tggtttaagc ctcttagaat acaactccat gaggttaata gtcagctatg     4260

tgtacaagag tctaatgacc tttggaggct atcaagatga ttttatggta gtcattaaca     4320

atacacattc aaaggacaaa ccaacagaga aattactttt tgccatggca aaacccaaga     4380

ttcttgaaat cactcttttg atcgccagtt acataaacaa cttccatcag caaaaggcag     4440

catttcacca cctctctgct ccagcactgc tctcagccca gacccgggga ccccaagcca     4500

gaatgatggg aagccagcct cttctgtcaa gcagcagacc gaccaaaggc cccaccttac     4560

tctgaaagct ggggagcctg aacattcact ccttgtcctc catgctgtgg ctgtatcagc     4620

tccctacaag ttcgtttaca cctggcagca cggcagccac acaccggtat tccaaacctt     4680

aacaatgaag ggggttagtc tcttttattt gattcttaaa tattcaaata aatattaaca     4740

gtaaaacata aacacaaaat ttgccaacac actaattttc ttatagagta aatgagtaag     4800

aattcatcat tttttccatc tcccttctcc cttgtcatca gacacattgt gcaatgtggc     4860

ttttcttttc ttttcttttt ttcccctttt taatattctg gcaatcttta gaaagggaga     4920

ttccaaactc ccatttggta aaccagttga ttatttggaa atgttcactg ccaaaatagt     4980

aagtgctata actaaatgcg cttttaatta atgatatagt gtttggaaag gagtagaaca     5040

tgcagcataa gaaactgctg cagagtggtg cgaggagtac attttcagag caggtgcagt     5100

acatcttccg gctctatgaa tcattatgtg agaaagcagg ataacattag gtaacctgag     5160

cctcctgtgt ggtattagaa agtataccgt caccttttca catcactgga gtgtaaaatt     5220

taaaacaaga tggtgattcc tgacattcct tggctgtcag tgctgcccag attcagaaga     5280

atattgccca catttcactg tatttggtgc tgggtcattt tgaccttgct ttgttaataa     5340

tatctttaaa aacaaagaca atccttaaag ctttgctcct cacacattac cttctaatta     5400

tagtttgaaa atagattccc tacacataca tacatatgta tgcacagata gggtcttgct     5460

atgttgccca ggctggtctt gaactcctgg cctcaagcaa tcctctctcc tcagcctccc     5520

aaagtgctgg gattacaagt gtgagccacc acacctggct ccagaaattt tattttattt     5580

ttttgaggca gggtctcact ctggttgccc aggctggagt gcagtggtgc catcatagct     5640

cactgtagcc tcgaccttcc gggatcaagc aatcccactt cagcctcttg aatagctggg     5700

actagaagca tgcaccacca tgcccatcta atatttgtat ttttagtaga gacaggatct     5760

ccctatgttg tccagcctag tctcaaactc ctgggttcaa gcaatcctcc cacctcggcc     5820

tcccaaagtg ctgggattgc aggcatgagc caccgtgccc agcctcaaaa atatttttta     5880

aaagaaaaga gaaaataatt cttctgtcaa aggaggttaa attttagttg atagagtact     5940

taaatgcatt actttattag gttatgtaag tggtcagtgc attccagtat gtgtcacaac     6000

agtgtagttc atattcatga taaaaatgaa actgtgataa gacatgaaaa ttatattatt     6060

aaaatgttca attgtaatgg taatcatgag tatacttaat tttatttatg tatagaatat     6120

ttgtatttat tttttggaca tatatttatc actttgtcat tttttttaac caatttgaga     6180

aatgttagct gctgaattaa tttgttgccc gagccttcat attttcttct ttgctgcctt     6240

ctccctgtgg caatgtactg ttctcacatt aagcctttta aaaatgttcc atactgtatt     6300

agcatcctta gaagggacag aactaagaaa tacattgctc aaataatatt ttactttatt     6360

gataatgaca aaaagaatat tttttaaacc ccatcaaaat agatttcaat tgactgtttc     6420

ccctacatct tttgagccac agtcgcccat cgaataagca aatttgtttt tgagaataaa     6480

ctggtaacca gtttgtgatg actctcagaa gccttttggc tgggttacag aagagtttct     6540

aagttcctag agagccattt aataattagt tggtgagcca gaggcttgac agagctgtta     6600

cttatgtgtg agggctttat tctcaggcag tagtttattc atcatttggt aagcccctcc     6660

ccacactcct ctaatttaaa caagtagtga aggcttatct taaactgtgt agtaccttag     6720

acttggcatt tatttttgat agagcagaga taaaatattt tgatggaagg aaatcaattt     6780

tctgtaactg atgatgtgaa aattttattt tctgggaaat tatatagcca ttcaaaaatt     6840

caaagtatgt tattatgatt ggttacaaga gaataatgtt acatgtttaa ttgtaatatt     6900

tgtctcctat cattttcttc cctttcagtc ataataaatg atttacaaaa cccaaaaaaa     6960

aaaaaaaaaa aa                                                         6972


<210>  789
<211>  1493
<212>  PRT
<213>  Homo Sapiens

<400>  789

Met Ala Glu Leu Ser Glu Pro Glu Gly Pro Val Asp Trp Lys Glu Arg 
1               5                   10                  15      


Cys Val Ala Leu Glu Ser Gln Leu Met Lys Phe Arg Val Gln Ala Ser 
            20                  25                  30          


Lys Ile Arg Glu Leu Leu Ala Glu Lys Met Gln Gln Leu Glu Arg Gln 
        35                  40                  45              


Val Ile Asp Ala Glu Arg Gln Ala Glu Lys Ala Phe Gln Gln Val Gln 
    50                  55                  60                  


Val Met Glu Asp Lys Leu Lys Ala Ala Asn Ile Gln Thr Ser Glu Ser 
65                  70                  75                  80  


Glu Thr Arg Leu Tyr Asn Lys Cys Gln Asp Leu Glu Ser Leu Ile Gln 
                85                  90                  95      


Glu Lys Asp Asp Val Ile Gln Asn Leu Glu Leu Gln Leu Glu Glu Gln 
            100                 105                 110         


Lys Gln Ile Arg Ile Gln Glu Ala Lys Ile Ile Glu Glu Lys Ala Ala 
        115                 120                 125             


Lys Ile Lys Glu Trp Val Thr Val Lys Leu Asn Glu Leu Glu Leu Glu 
    130                 135                 140                 


Asn Gln Asn Leu Arg Leu Ile Asn Gln Asn Gln Thr Glu Glu Ile Arg 
145                 150                 155                 160 


Thr Met Gln Ser Lys Leu Gln Glu Val Gln Gly Lys Lys Ser Ser Thr 
                165                 170                 175     


Val Ser Thr Leu Lys Leu Ser Glu Gly Gln Arg Leu Ser Ser Leu Thr 
            180                 185                 190         


Phe Gly Cys Phe Leu Ser Arg Ala Arg Ser Pro Pro Gln Val Val Lys 
        195                 200                 205             


Ser Glu Glu Met Ser Lys Ile Ser Ser Lys Glu Pro Glu Phe Thr Glu 
    210                 215                 220                 


Gly Lys Asp Met Glu Glu Met Glu Ile Pro Glu Lys Ser Val Asp Asn 
225                 230                 235                 240 


Gln Val Leu Glu Asn Asn Arg Gly Gln Arg Thr Leu His Gln Thr Pro 
                245                 250                 255     


Cys Gly Ser Glu Gln Asn Arg Lys Thr Arg Thr Ser Phe Ala Thr Asp 
            260                 265                 270         


Gly Gly Ile Ser Gln Asn Ser Gly Ala Pro Val Ser Asp Trp Ser Ser 
        275                 280                 285             


Asp Glu Glu Asp Gly Ser Lys Gly Arg Ser Lys Ser Arg Cys Thr Ser 
    290                 295                 300                 


Thr Leu Ser Ser His Thr Ser Glu Glu Gly Val Gln Cys Ser Arg Met 
305                 310                 315                 320 


Gly Ser Glu Met Tyr Leu Thr Ala Ser Asp Asp Ser Ser Ser Ile Phe 
                325                 330                 335     


Glu Glu Glu Thr Phe Gly Ile Lys Arg Pro Glu His Lys Lys Leu Tyr 
            340                 345                 350         


Ser Trp Gln Gln Glu Ala Gln Trp Lys Ala Leu Asn Ser Pro Leu Gly 
        355                 360                 365             


Lys Gly Asn Ser Glu Leu Ser Lys Lys Glu Gln Asp Ser Ser Ser Asp 
    370                 375                 380                 


Glu Leu Asn Lys Lys Phe Gln Ser Gln Arg Leu Asp Tyr Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Glu Ala Asn Thr Pro Ser Pro Ile Leu Thr Pro Ala Leu Met 
                405                 410                 415     


Pro Lys His Pro Asn Ser Leu Ser Gly Lys Gly Thr Gln Leu Val Pro 
            420                 425                 430         


Ser Ser His Leu Pro Pro Pro Lys Leu Arg Ile Pro Asn Val Phe Ser 
        435                 440                 445             


Ile Ser Val Ala Leu Ala Lys Arg His Leu Ser Gln Pro Gln Leu Ser 
    450                 455                 460                 


Ser Asp Arg Met Phe Gly Thr Asn Arg Asn Ala Ile Ser Met Ile Arg 
465                 470                 475                 480 


Pro Leu Arg Pro Gln Glu Thr Asp Leu Asp Leu Val Asp Gly Asp Ser 
                485                 490                 495     


Thr Glu Val Leu Glu Asn Met Asp Thr Ser Cys Asp Asp Gly Leu Phe 
            500                 505                 510         


Ser Tyr Asp Ser Leu Asp Ser Pro Asn Ser Asp Asp Gln Glu His Cys 
        515                 520                 525             


Asp Ser Ala Lys Lys Val Ala Tyr Ser Lys Pro Pro Thr Pro Pro Leu 
    530                 535                 540                 


His Arg Phe Pro Ser Trp Glu Ser Arg Ile Tyr Ala Val Ala Lys Ser 
545                 550                 555                 560 


Gly Ile Arg Met Ser Glu Ala Phe Asn Met Glu Ser Val Asn Lys Asn 
                565                 570                 575     


Ser Ala Ala Thr Leu Ser Tyr Thr Thr Ser Gly Leu Tyr Thr Ser Leu 
            580                 585                 590         


Ile Tyr Lys Asn Met Thr Thr Pro Val Tyr Thr Thr Leu Lys Gly Lys 
        595                 600                 605             


Ala Thr Gln Ile Ser Ser Ser Pro Phe Leu Asp Asp Ser Ser Gly Ser 
    610                 615                 620                 


Glu Glu Glu Asp Ser Ser Arg Ser Ser Ser Arg Thr Ser Glu Ser Asp 
625                 630                 635                 640 


Ser Arg Ser Arg Ser Gly Pro Gly Ser Pro Arg Ala Met Lys Arg Gly 
                645                 650                 655     


Val Ser Leu Ser Ser Val Ala Ser Glu Ser Asp Tyr Ala Ile Pro Pro 
            660                 665                 670         


Asp Ala Tyr Ser Thr Asp Thr Glu Tyr Ser Gln Pro Glu Gln Lys Leu 
        675                 680                 685             


Pro Lys Thr Cys Ser Ser Ser Ser Asp Asn Gly Lys Asn Glu Pro Leu 
    690                 695                 700                 


Glu Lys Ser Gly Tyr Leu Leu Lys Met Ser Gly Lys Val Lys Ser Trp 
705                 710                 715                 720 


Lys Arg Arg Trp Phe Val Leu Lys Gly Gly Glu Leu Leu Tyr Tyr Lys 
                725                 730                 735     


Ser Pro Ser Asp Val Ile Arg Lys Pro Gln Gly His Ile Glu Leu Ser 
            740                 745                 750         


Ala Ser Cys Ser Ile Leu Arg Gly Asp Asn Lys Gln Thr Val Gln Leu 
        755                 760                 765             


Thr Thr Glu Lys His Thr Tyr Tyr Leu Thr Ala Asp Ser Pro Asn Ile 
    770                 775                 780                 


Leu Glu Glu Trp Ile Lys Val Leu Gln Asn Val Leu Arg Val Gln Ala 
785                 790                 795                 800 


Ala Asn Pro Leu Ser Leu Gln Pro Glu Gly Lys Pro Thr Met Lys Gly 
                805                 810                 815     


Leu Leu Thr Lys Val Lys His Gly Tyr Ser Lys Arg Val Trp Cys Thr 
            820                 825                 830         


Leu Ile Gly Lys Thr Leu Tyr Tyr Phe Arg Ser Gln Glu Asp Lys Phe 
        835                 840                 845             


Pro Leu Gly Gln Ile Lys Leu Trp Glu Ala Lys Val Glu Glu Val Asp 
    850                 855                 860                 


Arg Ser Cys Asp Ser Asp Glu Asp Tyr Glu Ala Ser Gly Arg Ser Leu 
865                 870                 875                 880 


Leu Ser Thr His Tyr Thr Ile Val Ile His Pro Lys Asp Gln Gly Pro 
                885                 890                 895     


Thr Tyr Leu Leu Ile Gly Ser Lys His Glu Lys Asp Thr Trp Leu Tyr 
            900                 905                 910         


His Leu Thr Val Ala Ala Gly Ser Asn Asn Val Asn Val Gly Ser Glu 
        915                 920                 925             


Phe Glu Gln Leu Val Cys Lys Leu Leu Asn Ile Asp Gly Glu Pro Ser 
    930                 935                 940                 


Ser Gln Ile Trp Arg His Pro Thr Leu Cys His Ser Lys Glu Gly Ile 
945                 950                 955                 960 


Ile Ser Pro Leu Thr Thr Leu Pro Ser Glu Ala Leu Gln Thr Glu Ala 
                965                 970                 975     


Ile Lys Leu Phe Lys Thr Cys Gln Leu Phe Ile Asn Ala Ala Val Asp 
            980                 985                 990         


Ser Pro Ala Ile Asp Tyr His Ile  Ser Leu Ala Gln Ser  Ala Leu Gln 
        995                 1000                 1005             


Ile Cys  Leu Thr His Pro Glu  Leu Gln Asn Glu Ile  Cys Cys Gln 
    1010                 1015                 1020             


Leu Ile  Lys Gln Thr Arg Arg  Arg Gln Pro Gln Asn  Gln Pro Gly 
    1025                 1030                 1035             


Pro Leu  Gln Gly Trp Gln Leu  Leu Ala Leu Cys Val  Gly Leu Phe 
    1040                 1045                 1050             


Leu Pro  His His Pro Phe Leu  Trp Leu Leu Arg Leu  His Leu Lys 
    1055                 1060                 1065             


Arg Asn  Ala Asp Ser Arg Thr  Glu Phe Gly Lys Tyr  Ala Ile Tyr 
    1070                 1075                 1080             


Cys Gln  Arg Cys Val Glu Arg  Thr Gln Gln Asn Gly  Asp Arg Glu 
    1085                 1090                 1095             


Ala Arg  Pro Ser Arg Met Glu  Ile Leu Ser Thr Leu  Leu Arg Asn 
    1100                 1105                 1110             


Pro Tyr  His His Ser Leu Pro  Phe Ser Ile Pro Val  His Phe Met 
    1115                 1120                 1125             


Asn Gly  Ile Tyr Gln Val Val  Gly Phe Asp Ala Ser  Thr Thr Val 
    1130                 1135                 1140             


Glu Glu  Phe Leu Asn Thr Leu  Asn Gln Asp Thr Gly  Met Arg Lys 
    1145                 1150                 1155             


Pro Ala  Gln Ser Gly Phe Ala  Leu Phe Thr Asp Asp  Pro Ser Gly 
    1160                 1165                 1170             


Arg Asp  Leu Glu His Cys Leu  Gln Gly Asn Ile Lys  Ile Cys Asp 
    1175                 1180                 1185             


Ile Ile  Ser Lys Trp Glu Gln  Ala Ser Lys Glu Gln  Gln Pro Gly 
    1190                 1195                 1200             


Lys Cys  Glu Gly Thr Arg Thr  Val Arg Leu Thr Tyr  Lys Asn Arg 
    1205                 1210                 1215             


Leu Tyr  Phe Ser Val Gln Ala  Arg Gly Glu Thr Asp  Arg Glu Lys 
    1220                 1225                 1230             


Leu Leu  Leu Met Tyr Gln Thr  Asn Asp Gln Ile Ile  Asn Gly Leu 
    1235                 1240                 1245             


Phe Pro  Leu Asn Lys Asp Leu  Ala Leu Glu Met Ala  Ala Leu Leu 
    1250                 1255                 1260             


Ser Gln  Val Glu Ile Gly Asp  Phe Glu Arg Pro Phe  Ser Thr Pro 
    1265                 1270                 1275             


Ala Gly  His Val Thr Asn Gln  Cys Lys Val Asn Gln  Thr Leu Lys 
    1280                 1285                 1290             


Gln Val  Ile Glu Lys Phe Tyr  Pro Lys Arg Tyr Arg  Asp Gly Cys 
    1295                 1300                 1305             


Ser Glu  Glu Gln Leu Arg Gln  Leu Cys Gln Arg Leu  Ser Thr Arg 
    1310                 1315                 1320             


Trp Met  Ala Leu Arg Gly His  Ser Ala Ala Asp Cys  Val Arg Ile 
    1325                 1330                 1335             


Tyr Leu  Thr Val Ala Arg Lys  Trp Pro Phe Phe Gly  Ala Lys Leu 
    1340                 1345                 1350             


Phe Leu  Ala Lys Pro Ile Thr  Pro Ser Ser Leu Gly  Ser Thr Phe 
    1355                 1360                 1365             


Leu Trp  Leu Ala Val His Glu  Asp Gly Leu Ser Leu  Leu Glu Tyr 
    1370                 1375                 1380             


Asn Ser  Met Arg Leu Ile Val  Ser Tyr Val Tyr Lys  Ser Leu Met 
    1385                 1390                 1395             


Thr Phe  Gly Gly Tyr Gln Asp  Asp Phe Met Val Val  Ile Asn Asn 
    1400                 1405                 1410             


Thr His  Ser Lys Asp Lys Pro  Thr Glu Lys Leu Leu  Phe Ala Met 
    1415                 1420                 1425             


Ala Lys  Pro Lys Ile Leu Glu  Ile Thr Leu Leu Ile  Ala Ser Tyr 
    1430                 1435                 1440             


Ile Asn  Asn Phe His Gln Gln  Lys Ala Ala Phe His  His Leu Ser 
    1445                 1450                 1455             


Ala Pro  Ala Leu Leu Ser Ala  Gln Thr Arg Gly Pro  Gln Ala Arg 
    1460                 1465                 1470             


Met Met  Gly Ser Gln Pro Leu  Leu Ser Ser Ser Arg  Pro Thr Lys 
    1475                 1480                 1485             


Gly Pro  Thr Leu Leu 
    1490             


<210>  790
<211>  3632
<212>  DNA
<213>  Homo Sapiens

<400>  790
actcactgcc cgggccgccc ggacagggag cttcgctggc gcgcttggcc ggcgacagga       60

caggttcggg acgtccatct gtccatccgt ccggagagaa attacagatc cgcagccccg      120

ggatggggcc ggccccgctg ccgctgctgc tgggcctctt cctccccgcg ctctggcgta      180

gagctatcac tgaggcaagg gaagaagcca agccttaccc gctattcccg ggaccttttc      240

cagggagcct gcaaactgac cacacaccgc tgttatccct tcctcacgcc agtgggtacc      300

agcctgcctt gatgttttca ccaacccagc ctggaagacc acatacagga aacgtagcca      360

ttccccaggt gacctctgtc gaatcaaagc ccctaccgcc tcttgccttc aaacacacag      420

ttggacacat aatactttct gaacataaag gtgtcaaatt taattgctca atcagtgtac      480

ctaatatata ccaggacacc acaatttctt ggtggaaaga tgggaaggaa ttgcttgggg      540

cacatcatgc aattacacag ttttatccag atgatgaagt tacagcaata atcgcttcct      600

tcagcataac cagtgtgcag cgttcagaca atgggtcgta tatctgtaag atgaaaataa      660

acaatgaaga gatcgtgtct gatcccatct acatcgaagt acaaggactt cctcacttta      720

ctaagcagcc tgagagcatg aatgtcacca gaaacacagc cttcaacctc acctgtcagg      780

ctgtgggccc gcctgagccc gtcaacattt tctgggttca aaacagtagc cgtgttaacg      840

aacagcctga aaaatccccc tccgtgctaa ctgttccagg cctgacggag atggcggtct      900

tcagttgtga ggcccacaat gacaaagggc tgaccgtgtc caagggagtg cagatcaaca      960

tcaaagcaat tccctcccca ccaactgaag tcagcatccg taacagcact gcacacagca     1020

ttctgatctc ctgggttcct ggttttgatg gatactcccc gttcaggaat tgcagcattc     1080

aggtcaagga agctgatccg ctgagtaatg gctcagtcat gatttttaac acctctgcct     1140

taccacatct gtaccaaatc aagcagctgc aagccctggc taattacagc attggtgttt     1200

cctgcatgaa tgaaataggc tggtctgcag tgagcccttg gattctagcc agcacgactg     1260

aaggagcccc atcagtagca cctttaaatg tcactgtgtt tctgaatgaa tctagtgata     1320

atgtggacat cagatggatg aagcctccga ctaagcagca ggatggagaa ctggtgggct     1380

accggatatc ccacgtgtgg cagagtgcag ggatttccaa agagctcttg gaggaagttg     1440

gccagaatgg cagccgagct cggatctctg ttcaagtcca caatgctacg tgcacagtga     1500

ggattgcagc cgtcaccaga gggggagttg ggcccttcag tgatccagtg aaaatattta     1560

tccctgcaca cggttgggta gattatgccc cctcttcaac tccggcgcct ggcaacgcag     1620

atcctgtgct catcatcttt ggctgctttt gtggatttat tttgattggg ttgattttat     1680

acatctcctt ggccatcaga aaaagagtcc aggagacaaa gtttgggaat gcattcacag     1740

aggaggattc tgaattagtg gtgaattata tagcaaagaa atccttctgt cggcgagcca     1800

ttgaacttac cttacatagc ttgggagtca gtgaggaact acaaaataaa ctagaagatg     1860

ttgtgattga caggaatctt ctaattcttg gaaaaattct gggtgaagga gagtttgggt     1920

ctgtaatgga aggaaatctt aagcaggaag atgggacctc tctgaaagtg gcagtgaaga     1980

ccatgaagtt ggacaactct tcacagcggg agatcgagga gtttctcagt gaggcagcgt     2040

gcatgaaaga cttcagccac ccaaatgtca ttcgacttct aggtgtgtgt atagaaatga     2100

gctctcaagg catcccaaag cccatggtaa ttttaccctt catgaaatac ggggacctgc     2160

atacttactt actttattcc cgattggaga caggaccaaa gcatattcct ctgcagacac     2220

tattgaagtt catggtggat attgccctgg gaatggagta tctgagcaac aggaattttc     2280

ttcatcgaga tttagctgct cgaaactgca tgttgcgaga tgacatgact gtctgtgttg     2340

cggacttcgg cctctctaag aagatttaca gtggcgatta ttaccgccaa ggccgcattg     2400

ctaagatgcc tgttaaatgg atcgccatag aaagtcttgc agaccgagtc tacacaagta     2460

aaagtgatgt gtgggcattt ggcgtgacca tgtgggaaat agctacgcgg ggaatgactc     2520

cctatcctgg ggtccagaac catgagatgt atgactatct tctccatggc cacaggttga     2580

agcagcccga agactgcctg gatgaactgt atgaaataat gtactcttgc tggagaaccg     2640

atcccttaga ccgccccacc ttttcagtat tgaggctgca gctagaaaaa ctcttagaaa     2700

gtttgcctga cgttcggaac caagcagacg ttatttacgt caatacacag ttgctggaga     2760

gctctgaggg cctggcccag ggctccaccc ttgctccact ggacttgaac atcgaccctg     2820

actctataat tgcctcctgc actccccgcg ctgccatcag tgtggtcaca gcagaagttc     2880

atgacagcaa acctcatgaa ggacggtaca tcctgaatgg gggcagtgag gaatgggaag     2940

atctgacttc tgccccctct gctgcagtca cagctgaaaa gaacagtgtt ttaccggggg     3000

agagacttgt taggaatggg gtctcctggt cccattcgag catgctgccc ttgggaagct     3060

cattgcccga tgaacttttg tttgctgacg actcctcaga aggctcagaa gtcctgatgt     3120

gaggagaggt gcggggagac attccaaaaa tcaagccaat tcttctgctg taggagaatc     3180

caattgtacc tgatgttttt ggtatttgtc ttccttacca agtgaactcc atggccccaa     3240

agcaccagat gaatgttgtt aagtaagctg tcattaaaaa tacataatat atatttattt     3300

aaagagaaaa aatatgtgta tatcatggaa aaagacaagg atattttaat aaaacattac     3360

ttatttcatt tcacttatct tgcatatctt aaaattaagc ttcagctgct ccttgatatt     3420

aacatttgta cagagttgaa gttgtttttt caagttcttt tctttttcat gactattaaa     3480

tgtaaaaata tttgtaaaat gaaatgccat atttgacttg gcttctggtc ttgatgtatt     3540

tgataagaat gattcattca atgtttaaag ttgtataact gattaatttt ctgatatggc     3600

ttcctaataa aatatgaata aggaagaaaa aa                                   3632


<210>  791
<211>  999
<212>  PRT
<213>  Homo Sapiens

<400>  791

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  792
<211>  2937
<212>  DNA
<213>  Homo Sapiens

<400>  792
atgggcacgc gtctgccgct cgtcctgcgc cagctccgcc gcccgcccca gcccccgggc       60

cctccgcgcc gcctccgtgt gccctgtcgc gctagcagcg gcggcggcgg aggcggcggc      120

ggtggccggg agggcctgct tggacagcgg cggccgcagg atggccaggc ccggagcagc      180

tgcagccccg gcggccgaac gcccgcggcg cgggactcca tcgtcagaga agtcattcag      240

aattcaaaag aagttctaag tttattgcaa gaaaaaaacc ctgccttcaa gccggttctt      300

gcaattatcc aggcaggtga cgacaacttg atgcaggaaa tcaaccagaa tttggctgag      360

gaggctggtc tgaacatcac tcacatttgc ctccctccag atagcagtga agccgagatt      420

atagatgaaa tcttaaagat caatgaagat accagagtac atggccttgc ccttcagatc      480

tctgagaact tgtttagcaa caaagtcctc aatgccttga aaccagaaaa agatgtggat      540

ggagtaacag acataaacct ggggaagctg gtgcgagggg atgcccatga atgttttgtt      600

tcacctgttg ccaaagctgt aattgaactt cttgaaaaat caggtgtcaa cctagatgga      660

aagaagattt tggtagtggg ggcccatggg tctttggaag ctgctctaca atgcctgttc      720

cagagaaaag ggtccatgac aatgagcatc cagtggaaaa cacgccagct tcaaagcaag      780

cttcacgagg ctgacattgt ggtcctaggc tcacctaagc cagaagagat tccccttact      840

tggatacaac caggaactac tgttctcaac tgctcccatg acttcctgtc agggaaggtt      900

gggtgtggct ctccaagaat acattttggt ggactcattg aggaagatga tgtgattctc      960

cttgctgcag ctctgcgaat tcagaacatg gtcagtagtg gaaggagatg gcttcgtgaa     1020

cagcagcaca ggcggtggag acttcactgc ttgaaacttc agcctctctc ccctgtgcca     1080

agtgacattg agatttcaag aggacaaact ccaaaagctg tggatgtcct tgccaaggag     1140

attggattgc ttgcagatga aattgaaatc tatggcaaaa gcaaagccaa agtacgtttg     1200

tccgtgctag aaaggttaaa ggatcaagca gatggaaaat acgtcttagt tgctgggatc     1260

acacccaccc ctcttggaga agggaagagc acagtcacca tcgggcttgt gcaggctctg     1320

accgcacacc tgaatgtcaa ctcctttgcc tgcttgaggc agccttccca aggaccgacg     1380

tttggagtga aaggaggagc cgcgggtggt ggatatgccc aggtcatccc catggaggag     1440

ttcaaccttc acttgactgg agacatccac gccatcaccg ctgccaataa cttgctggct     1500

gccgccatcg acacgaggat tcttcatgaa aacacgcaaa cagataaggc tctgtataat     1560

cggctggttc ctttagtgaa tggtgtcaga gaattttcag aaattcagct tgctcggcta     1620

aaaaaactgg gaataaataa gactgatccg agcacactga cagaagagga agtgagtaaa     1680

tttgcccgtc tcgacatcga cccatctacc atcacgtggc agagagtatt ggatacaaat     1740

gaccgatttc tacgaaaaat aaccatcggg cagggaaaca cagagaaggg ccattaccgg     1800

caggcgcagt ttgacatcgc agtggccagc gagatcatgg cggtgctggc cctgacggac     1860

agcctcgcag acatgaaggc acggctggga aggatggtgg tggccagtga caaaagcggg     1920

cagcctgtga cagcagatga tttgggggtg acaggtgctt tgacagtttt gatgaaagat     1980

gcaataaaac caaacctgat gcagaccctg gaagggacac ctgtgttcgt gcatgcgggc     2040

ccttttgcta acattgctca cggcaactct tcagtgttgg ctgataaaat tgccctgaaa     2100

ctggttggtg aagaaggatt tgtagtgacc gaagctggct ttggtgctga catcggaatg     2160

gagaaattct tcaacatcaa gtgccgagct tccggcttgg tgcccaacgt ggttgtgtta     2220

gtggcaacgg tgcgagctct gaagatgcat ggaggcgggc caagtgtaac ggctggtgtt     2280

cctcttaaga aagaatatac agaggagaac atccagctgg tggcagacgg ctgctgtaac     2340

ctccagaagc aaattcagat cactcagctc tttggggttc ccgttgtggt ggctctgaat     2400

gtcttcaaga ccgacacccg cgctgagatt gacttggtgt gtgagcttgc aaagcgggct     2460

ggtgcctttg atgcagtccc ctgctatcac tggtccgttg gtggaaaagg atcggtggac     2520

ttggctcggg ctgtgagaga ggctgcgagt aaaagaagcc gattccagtt cctgtatgat     2580

gttcaggttc caattgtgga caagataagg accattgctc aggctgtcta tggagccaaa     2640

gatattgaac tctctcctga ggcacaagcc aaaatagatc gttacactca acagggtttt     2700

ggaaatttgc ccatctgcat ggcaaagacc cacctttctc tatctcacca acctgacaaa     2760

aaaggtgtgc caagggactt catcttacct atcagtgacg tccgggccag cataggcgct     2820

gggttcattt accctttggt cggaacgatg agcaccatgc caggactgcc cacccggccc     2880

tgcttttatg acatagatct tgataccgaa acagaacaag ttaaaggctt gttctaa        2937


<210>  793
<211>  978
<212>  PRT
<213>  Homo Sapiens

<400>  793

Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser Pro 
            260                 265                 270         


Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr Val 
        275                 280                 285             


Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly Ser 
    290                 295                 300                 


Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile Leu 
305                 310                 315                 320 


Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg Arg 
                325                 330                 335     


Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu Lys 
            340                 345                 350         


Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg Gly 
        355                 360                 365             


Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu Leu 
    370                 375                 380                 


Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg Leu 
385                 390                 395                 400 


Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val Leu 
                405                 410                 415     


Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr Val 
            420                 425                 430         


Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn Ser 
        435                 440                 445             


Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val Lys 
    450                 455                 460                 


Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu Glu 
465                 470                 475                 480 


Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala Asn 
                485                 490                 495     


Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn Thr 
            500                 505                 510         


Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn Gly 
        515                 520                 525             


Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu Gly 
    530                 535                 540                 


Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser Lys 
545                 550                 555                 560 


Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg Val 
                565                 570                 575     


Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln Gly 
            580                 585                 590         


Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala Val 
        595                 600                 605             


Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp 
    610                 615                 620                 


Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly 
625                 630                 635                 640 


Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val 
                645                 650                 655     


Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly 
            660                 665                 670         


Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly 
        675                 680                 685             


Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu 
    690                 695                 700                 


Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met 
705                 710                 715                 720 


Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn 
                725                 730                 735     


Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly 
            740                 745                 750         


Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu 
        755                 760                 765             


Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln 
    770                 775                 780                 


Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn 
785                 790                 795                 800 


Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu 
                805                 810                 815     


Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser 
            820                 825                 830         


Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala 
        835                 840                 845             


Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro 
    850                 855                 860                 


Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys 
865                 870                 875                 880 


Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr 
                885                 890                 895     


Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu 
            900                 905                 910         


Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile 
        915                 920                 925             


Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr 
    930                 935                 940                 


Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro 
945                 950                 955                 960 


Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly 
                965                 970                 975     


Leu Phe 
        


<210>  794
<211>  6998
<212>  DNA
<213>  Homo Sapiens

<400>  794
agccgccggg gaggggacga gacgcagacc acacgttgcc cacgtgcgag gaccgggcag       60

gggctcagcc cctaggccgc ccggtgcgtg gggcggcggg ggctggcttt gagtcacccc      120

cgcttgtgcc agcttccccg gctcggcgga gactggcttg gggatgcctg gccgcccggc      180

ccccttctcg gacgcggcgt ggggagcgag ctggagttaa ggatgaaggg gcggccggcg      240

agtcccagtg agagcggagg gtgccagagg tagggggccg agaaacaaag ttcccggggc      300

ttcctccggg gccgcggtcg gggctgcgcg tttgaccgcc cccctcctcg cgaaggcaat      360

ggcttccaaa ctcctgcgcg cggtcatcct cgggccgccc ggctcgggca agggcaccgt      420

gtgccagagg atcgcccaga actttggtct ccagcatctc tccagcggcc acttcttgcg      480

ggagaacatc aaggccagca ccgaagttgg tgagatggca aagcagtata tagagaaaag      540

tcttttggtt ccagaccatg tgatcacacg cctaatgatg tccgagttgg agaacaggcg      600

tggccagcac tggctccttg atggttttcc taggacatta ggacaagccg aagccctgga      660

caaaatctgt gaagtggatc tagtgatcag tttgaatatt ccatttgaaa cacttaaaga      720

tcgtctcagc cgccgttgga ttcaccctcc tagcggaagg gtatataacc tggacttcaa      780

tccacctcat gtacatggta ttgatgacgt cactggtgaa ccgttagtcc agcaggagga      840

tgataaaccc gaagcagttg ctgccaggct aagacagtac aaagacgtgg caaagccagt      900

cattgaatta tacaagagcc gaggagtgct ccaccaattt tccggaacgg agacgaacaa      960

aatctggccc tacgtttaca cacttttctc aaacaagatc acacctattc agtccaaaga     1020

agcatattga ccctgcccaa tggaagaacc aggaagatgt ggtcattcat tcaatagtgt     1080

gtgtagtatt ggtgctgtgt ccaaattaga agctagctga ggtagcttgc agcatctttt     1140

ctagttgaaa tggtgaactg ataggaaaac aaatgagtag aaagagttca tgaagaggcc     1200

ctcctctgcc tttcaaaagg ctggtcacct acacatgttt aaggtgtctc tgcacatgtc     1260

tcaagcccat cacaagaaag caagtacagt gtggatttca aatggtgtgt aacttcagct     1320

ccagctggtt tttgacagct gttgctgtgg taatattttt gacatgtgat ggtgatagtc     1380

tctggttctc cccatcccca caaaggctgt tgaaccacag caccaggaag cctgagaatg     1440

aatcctgagg gctctagccc aggctttgtc ccaggctttc tggtgtgtgc cctcctggta     1500

acagtgaaat tgaagctact tactcatagt ggttgtttct ctggtcttga gtgactgtgt     1560

ccacagttca tttttttccg gtaggaataa ctccttttct acatccacgc tccatagagt     1620

ctctcctttt cagacatcct gggatgaaag aatttggctt ttttttttct tttttttttt     1680

ggacatctgt tttcactctt aggcttttaa acaatagtta ttgcttttat ccctctcaga     1740

ttctaataac tgagagcgat ggggctatat tgaatctctg tatgcactga gaactgagct     1800

atgaagagga tcttattaaa ctgctggtct gactttatgg attgacactg ttcctttctt     1860

ttattgtgaa aaaaaaaaaa aaccctgaaa gtcttgggaa ccccctaaag tcttttggga     1920

atcctcaaaa agcatgggaa gttaagtatt tagctacata aatgttgtaa gatcatatct     1980

tatgtataga agtaataaga ccatttggaa ttactggact aattgaatag ttaaggtttc     2040

tattcgggac aataaaatgt attttgaaag tgctgctaac tattgatgct gacagtgttt     2100

cactcctatg agtgacccaa acatattata aatatgtggt aaagggaatg gagcctgtgg     2160

ggttgagcag aatgttgtac tagctgtgcc tggactgagt ataacagctt tatgattatg     2220

agaaaacaaa ttctttattt tttttttctg ttccaaagat tcatcctatg gggtggccat     2280

aaagtctaga attagatact aatattttgt cattcattat aacatatcaa taaaccattt     2340

gttaaaagat ttgcctggtt tccagacttg gtggccacct tgaataattc ttgctgtctt     2400

ctgggaagga tgatgaaatt tattcctgct gccttaaaaa tatgtatccc ttcttcaccc     2460

atcatgactg tccccagtga gtgtccttta ctattcttgg gagtgactcc tgtctaactt     2520

ttcatactgg cgagaagaaa agaagcctat tttaacactt tagtggtgtt gaaacacatt     2580

acttactttc tgaagatgtc ccagtgaatc ctctgtcaat tcactgccat atgtaatcta     2640

tatgataagg aatgcatctt ccttctaagt actgcccaaa ctcttgccag ctcctctccc     2700

attgtccctt catgtgaata tttcttggct accttagtgg aaatatagat cagttttctc     2760

cccatccatc ctctcaaaca taatgagatt gtttactttt tagatttatg cagtgaaaat     2820

gcccagtcag gtctgaatcg tcagtgcatt atattgactc tgagcacttt agaatttaga     2880

gttgcaattg aatgccagct gtggagatgg ggtgcatatc agatatataa ataaagctca     2940

ggtttgctag ggaaccaggt atagagaaaa ataagtctga tatgaggaaa attgcacaat     3000

ttagagtagt tatgccgtag agaaaatttc cacaaactag gaaatgtaga gagttattct     3060

atagaatact caaaagagga aagtatgtga tttttggaaa caggaaaatc ttcaaacttc     3120

tttcttcact tccctttgtg tttagctgac cctccaatgt gatcattgcc tttggagttt     3180

gggagaggta cgggaagtgg cctgatccct gcttccatac ttcactcctc catccatcct     3240

tccctccctc ttcccctcca gctaaatgga caattctagc caacattgag tcactcaata     3300

agtctcaaca gtgggtgtgt ttgctgagat tgtccagcgg ttgagcagtt tggtctcacc     3360

tccctcgcta gttgagacca aaaagagaca aataactttt tcatggtctt tgaaacataa     3420

tgcttatttc gtggtcaatg gctttaaaaa aatctgtttc ttgttttctt caacaaactc     3480

actagttttc ccttaaatga tattgtaaaa attaaagtaa tcttgaaaat gttttgacaa     3540

aagtaaaatt aaagggacat cttttcttgt tttgtttttt ttttttctat tgccacacat     3600

gaccgttcct tcacctttaa gcaaagagag tggttcagat ggtttctaag atgccaacct     3660

gacctcgcat tctgtcattc tacccagctc ttaattcaat ttgcttccat tatcctaaca     3720

ggcttctttc ttacttagaa cttggaaagg ctgctgtatt taataccctc caacactaac     3780

gcagacttaa gataggtact gtttattgaa aacctactga gtgaaatgtg cggttttagg     3840

accttcataa acatctcatt taatctttct agcatcctgt gaaacagcca tgatttcacg     3900

ttgataaaca aagaagacag gggtcccagg gatgtgaagc atcttgccca ggcttctgct     3960

gctggtgacc agtgtagcca ggactccagc ccaggttttc ctgactcaga agactgagct     4020

ttttcctgga tgttattaat agctaattgt gtccaagcaa ccaagggcct tgagtctgct     4080

tggttctgct tatggcctca catcaagaaa tggagctagt ccatgtctgt agtcccaatg     4140

ctttgggaag ccatgatggg aaggttgtcg gaggccaaaa gttcaagacc aggctgggca     4200

atatcacaag actccatctc tacggaaaag taaaaaatta gccagtcatg gtggtgtaca     4260

cttatggtcc tagttactca ggagacttag gcaggaggat tgcttgatcc taggaattcg     4320

aggctgcagt gagctatgat tgcacctctg cacccaagcc tgggcgacac agcgagaccc     4380

tctctcttaa aaaaaaaaaa tagcagagct caccaaagtg atgttcacct ttttatgaca     4440

ttcctttttc ttagcttaag aaaagaaagc tgctagatga gagtcttagt tttcctgcat     4500

aagacctcct ttatgaatag aataaaagac tgtcaaagta ggctgggctt gggcccaggc     4560

taatctatga aggaagcaag ctcgtgttcc ttacctatcc ttttggtgtc cattggattg     4620

tgccccgaag tggcctttac ccttgagccg tccccagcca tggtgctcac acataggctt     4680

ttgagctcct tggagctatc cagatcctgc tcacttttcc ttcctgagat cagaacaaat     4740

caccccctta ctcccactcc aaacaaggcc ttgatgataa actaatcctt cctaaaatgc     4800

tggtaggtaa acaagcaatg atgaagcatt gaacacaggt taactcctga cttttgtacc     4860

attgtctatt ccattacaca ttaacatgac tctgaatgcc agatccaaac ctttgcccac     4920

catctgcttg tcgtgcaaca gttgaggcag taaccagggg agattcactt cctgtcttgt     4980

ccttccccag ggatcacccc cctgctgccc tctagcagcc aaactcagat gagttccatt     5040

gttaccctag gtgtgcccat ctctttggta gggaaggaga aaggtaagaa tagccatcag     5100

tgaggaagga ttcttggagc gaggagccac tgtggttttt cctgctattt aagatgttga     5160

gaccggataa ctttagaaag atacctgcac aaacccataa atagtgcttt tataaagttt     5220

agttcaccgg aacctgagtt cagtatttga cattagcttt ttgtccaaag agttgaagcc     5280

tgctggaggt ctttgctcaa ataataaata ccacatattt ccaagtgtgt tcaggtatag     5340

gcactaggta ctgtctgttt acttcatgtt aggcacatta catgcattgg ctaatcaaat     5400

cctcatcaat tacatatgta ataatctaaa cttgcctcct tgtattataa atggaaataa     5460

tcctgtttat ttaaacgggt tttcatgtac ctgtagggat taggaaactc aaatggcctt     5520

tttaatacct ttccctagtt tgagctccct gttctcttta acagataaaa caacatattt     5580

gcttcagcct ggaatctgtt tttggtgctt tggtgcagag acaggaaatg ggcactcaga     5640

gtcacactgg tagttgcaca ctgtatctac agagggcgtg tctcatctgt actctgctgg     5700

gttacaggat ttcagtaggt atttgtgtcc acctgagaat tctgtttatt acctttcatt     5760

tgacagtgtc tttcctttct gcagttgatt ttgctagaga ggcaattcat aaggtgaggt     5820

cctgttcata gtatgacttg ctttctcaat atctccttca atttttagta actcttggtc     5880

tatttggtgt ctttaaaaaa aataacctag taataaagac ttcttttaat gtggaaatgt     5940

ggtctggtag taagttattt ctttccacat gtaactgacc caatctggtt tccaaatgag     6000

aagtgtgcag gccccagagg ttgagaagcc atatttcaac tgtgaaaaaa atctgcttcc     6060

tgcatctgtt gaaatatagt tgttcatact tgccatccct tatctttctt gtaacaattt     6120

gcacagttct tgccagaata aatgccatta tctgtatgtt tcagggagtt ccccaatttg     6180

atcatttttg tgtgtgtgtg gtgtgtgtgt gagagagaga gatactgcag taaaacattt     6240

ctaaaggatg aaagctcttg tatggcatag atatgaattc cttcctctgg taataattag     6300

gttattccca gaagcacagt gtcattcttt aaataaaagc tttcctgttt aaagcttttc     6360

aaaggagcag accaccttga agattccccc tagggttgat atgtgtctaa ttcattttat     6420

aaaaattatt cttgtcttca ttttaaagct ttggctatat agtcagaaat gtcctaaata     6480

acaaactatt ttgtatttaa tttagggaag actaaaggga agaaaaatga aaactcagtc     6540

tttatgtaag ctccaaggat attagggctt aaagggcttt tctagtttta tgagaatttg     6600

tactactgat ttttatatat tcctgttttt gagatgaaca gatctctggg gaaattgttg     6660

agttacaatg gcatttcact gtgatccctc tcaagctcag atcagttcta taacccaatg     6720

acaacctgtc tctttggttt actgtcctgt gaaatgtcag ctcaagtttc ccagaagtcg     6780

tgtgtttatg atgagtcaga gtgcttttcc tcggtgggac agttgctggc cctcttaatt     6840

ttggtgtatg tgcttccaag tatctaaacc tccagtctga tctgtatatg ctatcctaac     6900

tgttaattgt attattgatt atgttgatta tcttgcttga aggttcatac ttttcaattt     6960

gatagaaata aagttttttt ctgcttatag ctagcgaa                             6998


<210>  795
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  795

Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser 
1               5                   10                  15      


Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln 
            20                  25                  30          


His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr 
        35                  40                  45              


Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val 
    50                  55                  60                  


Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg 
65                  70                  75                  80  


Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln 
                85                  90                  95      


Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu 
            100                 105                 110         


Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile 
        115                 120                 125             


His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His 
    130                 135                 140                 


Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu 
145                 150                 155                 160 


Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp 
                165                 170                 175     


Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His 
            180                 185                 190         


Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr 
        195                 200                 205             


Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr 
    210                 215                 220             


<210>  796
<211>  4402
<212>  DNA
<213>  Homo Sapiens

<400>  796
cgtaacccag gcagctgggg agcctgggct gtggccctag gagggggcgc ggcggcgggc       60

tctctccttt tgttgttgtt tcctcagcct ggggagctga aggggagacg cgtctgggtg      120

gggctgctcg gagcccgggc ctggtggccc ctggggctcc cgggcgggca gggtagggca      180

gagtagagcg ggcttcaaca tgatggcggc cgaggccggc agtgaggagg gcggcccggt      240

aacagccgga gctggaggag gcggcgcggc agcgggctcc agtgcctatc ccgcagtgtg      300

tcgggtgaag atacccgcgg ccctgcctgt ggcagccgcc ccctatcctg ggctggtgga      360

gaccggagtg gctggaactc tgggtggcgg agccgctttg gggtcagagt tcctaggagc      420

cgggtctgtg gcaggggcac tggggggagc tggactgaca gggggaggta ctgctgctgg      480

cgtagctggt gctgctgctg gcgtggccgg tgctgctgtt gctggaccta gtggagacat      540

ggctctcacc aaactgccca cttcgttgct tgctgagact ctcgggccag gcggcggttt      600

tccccctctg ccccctcccc cttacctgcc ccctttgggg gcgggcctcg ggacagtgga      660

cgaaggtgac tctctggatg gaccagaata cgaggaggaa gaggtggcca taccgttgac      720

cgctcctcca actaaccagt ggtatcacgg aaaacttgac agaacgatag cagaagaacg      780

cctcaggcag gcagggaagt ctggcagtta tcttataaga gagagtgatc ggaggccagg      840

gtcctttgta ctttcatttc ttagccagat gaatgttgtc aaccatttta ggattattgc      900

tatgtgtgga gattactaca ttggtggaag acgtttttct tcactgtcag acctaatagg      960

ttattacagt catgtttctt gtttgcttaa aggagaaaaa ttactttacc cagttgcacc     1020

accagagcca gtagaagata gaaggcgtgt acgagctatt ctaccttaca caaaagtacc     1080

agacactgat gaaataagtt tcttaaaagg agatatgttc attgttcata atgaattaga     1140

agatggatgg atgtgggtta caaatttaag aacagatgaa caaggcctta ttgttgaaga     1200

cctagtagaa gaggtgggcc gggaagaaga tccacatgaa ggaaaaatat ggttccatgg     1260

gaagatttcc aaacaggaag cttataattt actaatgaca gttggtcaag tctgcagttt     1320

tcttgtgagg ccctcagata atactcctgg cgattattca ctttatttcc ggaccaatga     1380

aaatattcag cgatttaaaa tatgtccaac gccaaacaat cagtttatga tgggaggccg     1440

gtattataac agcattgggg acatcataga tcactatcga aaagaacaga ttgttgaagg     1500

atattatctt aaggaacctg taccaatgca ggatcaagaa caagtactca atgacacagt     1560

ggatggcaag gaaatctata ataccatccg tcgtaaaaca aaggatgcct tttataaaaa     1620

cattgttaag aaaggttatc ttctgaaaaa gggcaaagga aaacgttgga aaaatttata     1680

ttttatctta gagggtagtg atgcccaact tatttatttt gaaagcgaaa aacgagctac     1740

caaaccaaaa ggattaatag atctcagtgt atgttctgtc tatgtcgttc atgatagtct     1800

ctttggcagg ccaaactgtt ttcagatagt agttcagcac tttagtgaag aacattacat     1860

cttttacttt gcaggagaaa ctccagaaca agcagaggat tggatgaaag gtctgcaggc     1920

attttgcaat ttacggaaaa gtagtccagg gacatccaat aaacgccttc gtcaggtcag     1980

cagccttgtt ttacatattg aagaagccca taaactccca gtaaaacatt ttactaatcc     2040

atattgtaac atctacctga atagtgtcca agtagcaaaa actcatgcaa gggaagggca     2100

aaacccagta tggtcagaag agtttgtctt tgatgatctt cctcctgaca tcaatagatt     2160

tgaaataact cttagtaata aaacaaagaa aagcaaagat cctgatatct tatttatgcg     2220

ctgccagttg agccgattac agaaagggca tgccacagat gaatggtttc tgctcagctc     2280

ccatatacca ttaaaaggta ttgaaccagg gtccctgcgt gttcgagcac gatactctat     2340

ggaaaaaatc atgccagaag aagagtacag tgaatttaaa gagcttatac tgcaaaagga     2400

acttcatgta gtctatgctt tatcacatgt atgtggacaa gaccgaacac tactggccag     2460

catcctactg aggatttttc ttcacgaaaa gcttgaatcg ttgttgttat gcacactaaa     2520

tgacagagaa ataagcatgg aagatgaagc cactacccta tttcgagcca caacacttgc     2580

aagcaccttg atggagcagt atatgaaagc cactgctaca cagtttgttc atcatgcttt     2640

gaaagactct attttaaaga taatggaaag caagcagtct tgtgagttaa gtccatcaaa     2700

gttagaaaaa aatgaagatg tgaacactaa tttaacacac ctattgaaca tactttcaga     2760

gcttgtggag aaaatattca tggcttcaga aatacttcca ccgacattga gatatattta     2820

tgggtgttta cagaaatctg ttcagcataa gtggcctaca aataccacca tgagaacaag     2880

agttgttagt ggttttgttt ttcttcgact catctgtcct gccatcctga atccacggat     2940

gttcaatatc atctcagatt ctccatctcc tattgctgca agaacactga tattagtggc     3000

taaatctgtg cagaacttag caaatcttgt ggaatttgga gctaaggagc cctacatgga     3060

aggtgtcaat ccattcatca aaagcaacaa acatcgtatg atcatgtttt tagatgaact     3120

tgggaatgta cctgaacttc cggacactac agagcattct agaacggacc tgtcccgtga     3180

tttagcagca ttgcatgaga tttgcgtggc tcattcagat gaacttcgaa cgctcagtaa     3240

tgagcgtggt gcacagcagc acgtattgaa aaagcttctg gctataacag aactgcttca     3300

acaaaaacaa aaccagtata caaaaaccaa tgatgtcagg tagcagcctt cgccccagtg     3360

ttctgcatgg attcagcatg tccaacatgg taattcactt cagtttaatg tctcctttgc     3420

tcttgccaaa aaatagcaca cttttccaca ttccagtgat gtgtgagcta tgcaaacaaa     3480

atccaagatt ctgctggtga ataactatgc cagcaacctt gtaagctatc tgtgcaggat     3540

atttgcacta tttccacatg gaatcaatct ttaacaacct ctgagccttg gtgtacagac     3600

cacctttcac aaaacgaaat gctatgactg tatcttgata tctcgaactt tcaaaatata     3660

ttttcagtac acccagttgc caaagttttg ctgtctctta gagaaagaac tatgaaatca     3720

actgacaaga aacacattct tattgacaat tgtgtataac tggattgcag actgttctta     3780

ctgtaactac ttcctgatta ggaatatgac catttgactg ttcaatgatt atttgtattt     3840

acagtttcca gagtttgtca ttataatagg aacaatcttt gctgtatact tttaaaaaat     3900

actctgctat ttctcttgct ggaactgttg aaagaaaata tatagaatga tctattgctc     3960

atcagcttta ttttttaaac atacgactta ttttgttgaa attgtcaaag actgtattta     4020

gatctcataa tgctttgtta aatgtttaca agtaaatagt ttgaattcag taaatattat     4080

tggttgttgt attgatcaat gcatgttacc cattcaacca ttttatagac taccaatttc     4140

ttttatgtta actagaatgc ttttgttaaa agttatttgt tcattatttg tgctacccct     4200

ttgattatgc agacaacctc atcagctgcc taacttatcc atctttgaac ttctgactac     4260

ttgttgtatc tgctggatat ttagttcaac tgtatagttt tatttacttc tgtatgtgta     4320

tttttgtgaa gtattcacaa aggttaagtt aaaataaaac caagggatat cttgcataat     4380

tgattaaaaa aaaaaaaaaa aa                                              4402


<210>  797
<211>  1047
<212>  PRT
<213>  Homo Sapiens

<400>  797

Met Met Ala Ala Glu Ala Gly Ser Glu Glu Gly Gly Pro Val Thr Ala 
1               5                   10                  15      


Gly Ala Gly Gly Gly Gly Ala Ala Ala Gly Ser Ser Ala Tyr Pro Ala 
            20                  25                  30          


Val Cys Arg Val Lys Ile Pro Ala Ala Leu Pro Val Ala Ala Ala Pro 
        35                  40                  45              


Tyr Pro Gly Leu Val Glu Thr Gly Val Ala Gly Thr Leu Gly Gly Gly 
    50                  55                  60                  


Ala Ala Leu Gly Ser Glu Phe Leu Gly Ala Gly Ser Val Ala Gly Ala 
65                  70                  75                  80  


Leu Gly Gly Ala Gly Leu Thr Gly Gly Gly Thr Ala Ala Gly Val Ala 
                85                  90                  95      


Gly Ala Ala Ala Gly Val Ala Gly Ala Ala Val Ala Gly Pro Ser Gly 
            100                 105                 110         


Asp Met Ala Leu Thr Lys Leu Pro Thr Ser Leu Leu Ala Glu Thr Leu 
        115                 120                 125             


Gly Pro Gly Gly Gly Phe Pro Pro Leu Pro Pro Pro Pro Tyr Leu Pro 
    130                 135                 140                 


Pro Leu Gly Ala Gly Leu Gly Thr Val Asp Glu Gly Asp Ser Leu Asp 
145                 150                 155                 160 


Gly Pro Glu Tyr Glu Glu Glu Glu Val Ala Ile Pro Leu Thr Ala Pro 
                165                 170                 175     


Pro Thr Asn Gln Trp Tyr His Gly Lys Leu Asp Arg Thr Ile Ala Glu 
            180                 185                 190         


Glu Arg Leu Arg Gln Ala Gly Lys Ser Gly Ser Tyr Leu Ile Arg Glu 
        195                 200                 205             


Ser Asp Arg Arg Pro Gly Ser Phe Val Leu Ser Phe Leu Ser Gln Met 
    210                 215                 220                 


Asn Val Val Asn His Phe Arg Ile Ile Ala Met Cys Gly Asp Tyr Tyr 
225                 230                 235                 240 


Ile Gly Gly Arg Arg Phe Ser Ser Leu Ser Asp Leu Ile Gly Tyr Tyr 
                245                 250                 255     


Ser His Val Ser Cys Leu Leu Lys Gly Glu Lys Leu Leu Tyr Pro Val 
            260                 265                 270         


Ala Pro Pro Glu Pro Val Glu Asp Arg Arg Arg Val Arg Ala Ile Leu 
        275                 280                 285             


Pro Tyr Thr Lys Val Pro Asp Thr Asp Glu Ile Ser Phe Leu Lys Gly 
    290                 295                 300                 


Asp Met Phe Ile Val His Asn Glu Leu Glu Asp Gly Trp Met Trp Val 
305                 310                 315                 320 


Thr Asn Leu Arg Thr Asp Glu Gln Gly Leu Ile Val Glu Asp Leu Val 
                325                 330                 335     


Glu Glu Val Gly Arg Glu Glu Asp Pro His Glu Gly Lys Ile Trp Phe 
            340                 345                 350         


His Gly Lys Ile Ser Lys Gln Glu Ala Tyr Asn Leu Leu Met Thr Val 
        355                 360                 365             


Gly Gln Val Cys Ser Phe Leu Val Arg Pro Ser Asp Asn Thr Pro Gly 
    370                 375                 380                 


Asp Tyr Ser Leu Tyr Phe Arg Thr Asn Glu Asn Ile Gln Arg Phe Lys 
385                 390                 395                 400 


Ile Cys Pro Thr Pro Asn Asn Gln Phe Met Met Gly Gly Arg Tyr Tyr 
                405                 410                 415     


Asn Ser Ile Gly Asp Ile Ile Asp His Tyr Arg Lys Glu Gln Ile Val 
            420                 425                 430         


Glu Gly Tyr Tyr Leu Lys Glu Pro Val Pro Met Gln Asp Gln Glu Gln 
        435                 440                 445             


Val Leu Asn Asp Thr Val Asp Gly Lys Glu Ile Tyr Asn Thr Ile Arg 
    450                 455                 460                 


Arg Lys Thr Lys Asp Ala Phe Tyr Lys Asn Ile Val Lys Lys Gly Tyr 
465                 470                 475                 480 


Leu Leu Lys Lys Gly Lys Gly Lys Arg Trp Lys Asn Leu Tyr Phe Ile 
                485                 490                 495     


Leu Glu Gly Ser Asp Ala Gln Leu Ile Tyr Phe Glu Ser Glu Lys Arg 
            500                 505                 510         


Ala Thr Lys Pro Lys Gly Leu Ile Asp Leu Ser Val Cys Ser Val Tyr 
        515                 520                 525             


Val Val His Asp Ser Leu Phe Gly Arg Pro Asn Cys Phe Gln Ile Val 
    530                 535                 540                 


Val Gln His Phe Ser Glu Glu His Tyr Ile Phe Tyr Phe Ala Gly Glu 
545                 550                 555                 560 


Thr Pro Glu Gln Ala Glu Asp Trp Met Lys Gly Leu Gln Ala Phe Cys 
                565                 570                 575     


Asn Leu Arg Lys Ser Ser Pro Gly Thr Ser Asn Lys Arg Leu Arg Gln 
            580                 585                 590         


Val Ser Ser Leu Val Leu His Ile Glu Glu Ala His Lys Leu Pro Val 
        595                 600                 605             


Lys His Phe Thr Asn Pro Tyr Cys Asn Ile Tyr Leu Asn Ser Val Gln 
    610                 615                 620                 


Val Ala Lys Thr His Ala Arg Glu Gly Gln Asn Pro Val Trp Ser Glu 
625                 630                 635                 640 


Glu Phe Val Phe Asp Asp Leu Pro Pro Asp Ile Asn Arg Phe Glu Ile 
                645                 650                 655     


Thr Leu Ser Asn Lys Thr Lys Lys Ser Lys Asp Pro Asp Ile Leu Phe 
            660                 665                 670         


Met Arg Cys Gln Leu Ser Arg Leu Gln Lys Gly His Ala Thr Asp Glu 
        675                 680                 685             


Trp Phe Leu Leu Ser Ser His Ile Pro Leu Lys Gly Ile Glu Pro Gly 
    690                 695                 700                 


Ser Leu Arg Val Arg Ala Arg Tyr Ser Met Glu Lys Ile Met Pro Glu 
705                 710                 715                 720 


Glu Glu Tyr Ser Glu Phe Lys Glu Leu Ile Leu Gln Lys Glu Leu His 
                725                 730                 735     


Val Val Tyr Ala Leu Ser His Val Cys Gly Gln Asp Arg Thr Leu Leu 
            740                 745                 750         


Ala Ser Ile Leu Leu Arg Ile Phe Leu His Glu Lys Leu Glu Ser Leu 
        755                 760                 765             


Leu Leu Cys Thr Leu Asn Asp Arg Glu Ile Ser Met Glu Asp Glu Ala 
    770                 775                 780                 


Thr Thr Leu Phe Arg Ala Thr Thr Leu Ala Ser Thr Leu Met Glu Gln 
785                 790                 795                 800 


Tyr Met Lys Ala Thr Ala Thr Gln Phe Val His His Ala Leu Lys Asp 
                805                 810                 815     


Ser Ile Leu Lys Ile Met Glu Ser Lys Gln Ser Cys Glu Leu Ser Pro 
            820                 825                 830         


Ser Lys Leu Glu Lys Asn Glu Asp Val Asn Thr Asn Leu Thr His Leu 
        835                 840                 845             


Leu Asn Ile Leu Ser Glu Leu Val Glu Lys Ile Phe Met Ala Ser Glu 
    850                 855                 860                 


Ile Leu Pro Pro Thr Leu Arg Tyr Ile Tyr Gly Cys Leu Gln Lys Ser 
865                 870                 875                 880 


Val Gln His Lys Trp Pro Thr Asn Thr Thr Met Arg Thr Arg Val Val 
                885                 890                 895     


Ser Gly Phe Val Phe Leu Arg Leu Ile Cys Pro Ala Ile Leu Asn Pro 
            900                 905                 910         


Arg Met Phe Asn Ile Ile Ser Asp Ser Pro Ser Pro Ile Ala Ala Arg 
        915                 920                 925             


Thr Leu Ile Leu Val Ala Lys Ser Val Gln Asn Leu Ala Asn Leu Val 
    930                 935                 940                 


Glu Phe Gly Ala Lys Glu Pro Tyr Met Glu Gly Val Asn Pro Phe Ile 
945                 950                 955                 960 


Lys Ser Asn Lys His Arg Met Ile Met Phe Leu Asp Glu Leu Gly Asn 
                965                 970                 975     


Val Pro Glu Leu Pro Asp Thr Thr Glu His Ser Arg Thr Asp Leu Ser 
            980                 985                 990         


Arg Asp Leu Ala Ala Leu His Glu  Ile Cys Val Ala His  Ser Asp Glu 
        995                 1000                 1005             


Leu Arg  Thr Leu Ser Asn Glu  Arg Gly Ala Gln Gln  His Val Leu 
    1010                 1015                 1020             


Lys Lys  Leu Leu Ala Ile Thr  Glu Leu Leu Gln Gln  Lys Gln Asn 
    1025                 1030                 1035             


Gln Tyr  Thr Lys Thr Asn Asp  Val Arg 
    1040                 1045         


<210>  798
<211>  2344
<212>  DNA
<213>  Homo Sapiens

<400>  798
ggtgcgtccg cgggtggctg ccccgcaggt gcgcgcggcc ggggctggcg gcgactctct       60

ccaccgggcc gcccgggagg ctcatgcagc gcggctgggt cccgcggcgc ccggatcggg      120

gaagtgaaag tgcctcggag gaggagggcc ggtccggcag tgcagccgcc tcacaggtcg      180

gcggacgggc caggcgggcg gcctcctgaa ccgaaccgaa tcggctcctc gggccgtcgt      240

cctcccgccc ctcctcgccc gccgccggag ttttctttcg gtttcttcca agattcctgg      300

ccttccctcg acggagccgg gcccagtgcg ggggcgcagg gcgcgggagc tccacctcct      360

cggctttccc tgcgtccaga ggctggcatg gcgcgggccg agtactgagc gcacggtcgg      420

ggcacagcag ggccgggggg tgcagctggc tcgcgcctcc tctccggccg ccgtctcctc      480

cggtccccgg cgaaagccat tgagacacca gctggacgtc acgcgccgga gcatgtctgg      540

gagtcagagc gaggtggctc catccccgca gagtccgcgg agccccgaga tgggacggga      600

cttgcggccc gggtcccgcg tgctcctgct cctgcttctg ctcctgctgg tgtacctgac      660

tcagccaggc aatggcaacg agggcagcgt cactggaagt tgttattgtg gtaaaagaat      720

ttcttccgac tccccgccat cggttcagtt catgaatcgt ctccggaaac acctgagagc      780

ttaccatcgg tgtctatact acacgaggtt ccagctcctt tcctggagcg tgtgtggggg      840

caacaaggac ccatgggttc aggaattgat gagctgtctt gatctcaaag aatgtggaca      900

tgcttactcg gggattgtgg cccaccagaa gcatttactt cctaccagcc ccccaatttc      960

tcaggcctca gagggggcat cttcagatat ccacacccct gcccagatgc tcctgtccac     1020

cttgcagtcc actcagcgcc ccaccctccc agtaggatca ctgtcctcgg acaaagagct     1080

cactcgtccc aatgaaacca ccattcacac tgcgggccac agtctggcag ctgggcctga     1140

ggctggggag aaccagaagc agccggaaaa aaatgctggt cccacagcca ggacatcagc     1200

cacagtgcca gtcctgtgcc tcctggccat catcttcatc ctcaccgcag ccctttccta     1260

tgtgctgtgc aagaggagga gggggcagtc accgcagtcc tctccagatc tgccggttca     1320

ttatatacct gtggcacctg actctaatac ctgagccaag aatggaagct tgtgaggaga     1380

cggactctat gttgcccagg ctgttatgga actcctgagt caagtgatcc tcccaccttg     1440

gcctctgaag gtgcgaggat tataggcgtc acctaccaca tccagcctac acgtatttgt     1500

taatatctaa cataggacta accagccact gccctctctt aggcccctca tttaaaaacg     1560

gttatactat aaaatctgct tttcacactg ggtgataata acttggacaa attctatgtg     1620

tattttgttt tgttttgctt tgctttgttt tgagacggag tctcgctctg tcatccaggc     1680

tggagtgcag tggcatgatc tcggctcact gcaaccccca tctcccaggt tcaagcgatt     1740

ctcctgcctc ctcctgagta gctgggacta caggtgctca ccaccacacc cggctaattt     1800

tttgtatttt tagtagagac ggggtttcac catgttgacc aggctggtct cgaactcctg     1860

acctggtgat ctgcccaccc aggcctccca aagtgctggg attaaaggtg tgagccacca     1920

tgcctggccc tatgtgtgtt ttttaactac taaaaattat ttttgtaatg attgagtctt     1980

ctttatggaa acaactggcc tcagcccttg cgcccttact gtgattcctg gcttcatttt     2040

ttgctgatgg ttccccctcg tcccaaatct ctctcccagt acaccagttg ttcctccccc     2100

acctcagccc tctcctgcat cctcctgtac ccgcaacgaa ggcctgggct ttcccaccct     2160

ccctccttag caggtgccgt gctgggacac catacgggtt ggtttcacct cctcagtccc     2220

ttgcctaccc cagtgagagt ctgatcttgt ttttattgtt attgctttta ttattattgc     2280

ttttattatc attaaaactc tagttcttgt tttgtctctc cgaaaaaaaa aaaaaaaaaa     2340

aaaa                                                                  2344


<210>  799
<211>  273
<212>  PRT
<213>  Homo Sapiens

<400>  799

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  800
<211>  4743
<212>  DNA
<213>  Homo Sapiens

<400>  800
gggaaggagg caggggtgct gagaaggcgg ctgctgggca gagccggtgg caagggcctc       60

ccctgccgct gtgccaggca ggcagtgcca aatccgggga gcctggagct ggggggaggg      120

ccggggacag cccggccctg ccccctcccc cgctgggagc ccaacaactt ctgaggaaag      180

tttggcaccc atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt      240

ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt      300

cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca      360

gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga      420

gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat      480

agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg      540

tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg      600

cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa      660

cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc      720

tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct      780

gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg      840

cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca      900

acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca      960

ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga     1020

ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg     1080

cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc     1140

ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc     1200

tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg     1260

ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc     1320

agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg     1380

gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg     1440

gagcctccca gtacccctgg aggcctggcg cccagggcaa gcacagccag tccaccagct     1500

ggtgaaggaa ccttcaactc ctgccttctc gtggccctgg tggtatgtac tgctaggagc     1560

agtcgtggcc gctgcctgtg tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa     1620

ggagacccgt tatggagaag tgtttgaacc aacagtggaa agaggtgaac tggtagtcag     1680

gtaccgcgtg cgcaagtcct acagtcgtcg gaccactgaa gctaccttga acagcctggg     1740

catcagtgaa gagctgaagg agaagctgcg ggatgtgatg gtggaccggc acaaggtggc     1800

cctggggaag actctgggag agggagagtt tggagctgtg atggaaggcc agctcaacca     1860

ggacgactcc atcctcaagg tggctgtgaa gacgatgaag attgccatct gcacgaggtc     1920

agagctggag gatttcctga gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt     1980

catgaggctc atcggtgtct gtttccaggg ttctgaacga gagagcttcc cagcacctgt     2040

ggtcatctta cctttcatga aacatggaga cctacacagc ttcctcctct attcccggct     2100

cggggaccag ccagtgtacc tgcccactca gatgctagtg aagttcatgg cagacatcgc     2160

cagtggcatg gagtatctga gtaccaagag attcatacac cgggacctgg cggccaggaa     2220

ctgcatgctg aatgagaaca tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat     2280

ctacaatggg gactactacc gccagggacg tatcgccaag atgccagtca agtggattgc     2340

cattgagagt ctagctgacc gtgtctacac cagcaagagc gatgtgtggt ccttcggggt     2400

gacaatgtgg gagattgcca caagaggcca aaccccatat ccgggcgtgg agaacagcga     2460

gatttatgac tatctgcgcc agggaaatcg cctgaagcag cctgcggact gtctggatgg     2520

actgtatgcc ttgatgtcgc ggtgctggga gctaaatccc caggaccggc caagttttac     2580

agagctgcgg gaagatttgg agaacacact gaaggccttg cctcctgccc aggagcctga     2640

cgaaatcctc tatgtcaaca tggatgaggg tggaggttat cctgaacccc ctggagctgc     2700

aggaggagct gaccccccaa cccagccaga ccctaaggat tcctgtagct gcctcactgc     2760

ggctgaggtc catcctgctg gacgctatgt cctctgccct tccacaaccc ctagccccgc     2820

tcagcctgct gataggggct ccccagcagc cccagggcag gaggatggtg cctgagacaa     2880

ccctccacct ggtactccct ctcaggatcc aagctaagca ctgccactgg ggaaaactcc     2940

accttcccac tttcccaccc cacgccttat ccccacttgc agccctgtct tcctacctat     3000

cccacctcca tcccagacag gtccctcccc ttctctgtgc agtagcatca ccttgaaagc     3060

agtagcatca ccatctgtaa aaggaagggg ttggattgca atatctgaag ccctcccagg     3120

tgttaacatt ccaagactct agagtccaag gtttaaagag tctagattca aaggttctag     3180

gtttcaaaga tgctgtgagt ctttggttct aaggacctga aattccaaag tctctaattc     3240

tattaaagtg ctaaggttct aaggcctact tttttttttt tttttttttt tttttttttt     3300

gcgatagagt ctcactgtgt cacccaggct ggagtgcagt ggtgcaatct cgcctcactg     3360

caaccttcac ctaccgagtt caagtgattt tcctgccttg gcctcccaag tagctgggat     3420

tacaggtgtg tgccaccaca cccggctaat ttttatattt ttagtagaga cagggtttca     3480

ccatgttggc caggctggtc taaaactcct gacctcaagt gatctgccca cctcagcctc     3540

ccaaagtgct gagattacag gcatgagcca ctgcactcaa ccttaagacc tactgttcta     3600

aagctctgac attatgtggt tttagatttt ctggttctaa catttttgat aaagcctcaa     3660

ggttttaggt tctaaagttc taagattctg attttaggag ctaaggctct atgagtctag     3720

atgtttattc ttctagagtt cagagtcctt aaaatgtaag attatagatt ctaaagattc     3780

tatagttcta gacatggagg ttctaaggcc taggattcta aaatgtgatg ttctaaggct     3840

ctgagagtct agattctctg gctgtaaggc tctagatcat aaggcttcaa aatgttatct     3900

tctcaagttc taagattcta atgatgatca attatagttt ctgaggcttt atgataatag     3960

attctcttgt ataagatcct agatcctaag ggtcgaaagc tctagaatct gcaattcaaa     4020

agttccaaga gtctaaagat ggagtttcta aggtccggtg ttctaagatg tgatattcta     4080

agacttactc taagatctta gattctctgt gtctaagatt ctagatcaga tgctccaaga     4140

ttctagatga ttaaataaga ttctaacggt ctgttctgtt tcaaggcact ctagattcca     4200

ttggtccaag attccggatc ctaagcatct aagttataag actctcacac tcagttgtga     4260

ctaactagac accaaagttc taataatttc taatgttgga cacctttagg ttctttgctg     4320

cattctgcct ctctaggacc atggttaaga gtccaagaat ccacatttct aaaatcttat     4380

agttctaggc actgtagttc taagactcaa atgttctaag tttctaagat tctaaaggtc     4440

cacaggtcta gactattagg tgcaatttca aggttctaac cctatactgt agtattcttt     4500

ggggtgcccc tctccttctt agctatcatt gcttcctcct ccccaactgt gggggtgtgc     4560

ccccttcaag cctgtgcaat gcattaggga tgcctccttt cccgcagggg atggacgatc     4620

tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt     4680

gtggactctg gtgcctccag aggggctcag gtcacataaa actttgtata tcaacgaaaa     4740

aaa                                                                   4743


<210>  801
<211>  894
<212>  PRT
<213>  Homo Sapiens

<400>  801

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  802
<211>  6091
<212>  DNA
<213>  Homo Sapiens

<400>  802
gctcgcgcgc ccaacggacc aggctggggc cgtgaggtaa ctgttgcagc cagcggaggt       60

gggaggcgac actgagtctc cagtcccgag aggtgcccga gggaaaagga ggcggcagct      120

aaactggtcc tggagagaag ccccttccgc ccctctcctc agccagcatg tcccggactc      180

cgccgctcct cagtccgcgc ggtggggacc ccgggccgtg gcggccggcg cagccctgac      240

gggttgcgaa ccagggggcg ccccgaacgc gggggttggg gtctgggagc gcgagcggcc      300

gctacggtac gagcggggtg tgctgagtcc cgtggccacc cccggcccca gccatgagga      360

gggacgagcg agacgccaaa gccatgcggt ccctgcagcc gccggatggg gccggctcgc      420

cccccgagag tctgaggaac ggctacgtga agagctgcgt gagccccttg cggcaggacc      480

ctccgcgcgg cttcttcttc cacctctgcc gcttctgcaa cgtggagctg cggccgccgc      540

cggcctctcc ccagcagccg cggcgctgct cccccttctg ccgggcgcgc ctctcgctgg      600

gcgccctggc tgcctttgtc ctcgccctgc tgctgggcgc ggaacccgag agctgggctg      660

ccggggccgc ctggctgcgg acgctgctga gcgtgtgttc gcacagcttg agccccctct      720

tcagcatcgc ctgtgccttc ttcttcctca cctgcttcct cacccggacc aagcggggac      780

ccggcccggg ccggagctgc ggctcctggt ggctgctggc gctgcccgcc tgctgttacc      840

tgggggactt cttggtgtgg cagtggtggt cttggccttg gggggatggc gacgcagggt      900

ccgcggcccc gcacacgccc ccggaggcgg cagcgggcag gttgctgctg gtgctgagct      960

gcgtagggct gctgctgacg ctcgcgcacc cgctgcggct ccggcactgc gttctggtgc     1020

tgctcctggc cagcttcgtc tggtgggtct ccttcaccag cctcgggtcg ctgccctccg     1080

ccctcaggcc gctgctctcc ggcctggtgg ggggcgctgg ctgcctgctg gccctggggt     1140

tggatcactt ctttcaaatc agggaagcgc ctcttcatcc tcgactgtcc agtgccgccg     1200

aagaaaaagt gcctgtgatc cgaccccgga ggaggtccag ctgcgtgtcg ttaggagaaa     1260

ctgcagccag ttactatggc agttgcaaaa tattcaggag accgtcgttg ccttgtattt     1320

ccagagaaca gatgattctt tgggattggg acttaaaaca atggtataag cctcattatc     1380

aaaattctgg aggtggaaat ggagttgatc tttcagtgct aaatgaggct cgcaatatgg     1440

tgtcagatct tctgactgat ccaagccttc caccacaagt catttcctct ctacggagta     1500

ttagtagctt aatgggtgct ttctcaggtt cctgtaggcc aaagattaat cctctcacac     1560

catttcctgg attttacccc tgttctgaaa tagaggaccc agctgagaaa ggggatagaa     1620

aacttaacaa gggactaaat aggaatagtt tgccaactcc acagctgagg agaagctcag     1680

gaacttcagg attgctacct gttgaacagt cttcaaggtg ggatcgtaat aatggcaaaa     1740

gacctcacca agaatttggc atttcaagtc aaggatgcta tctaaatggg ccttttaatt     1800

caaatctact gactatcccg aagcaaaggt catcttctgt atcactgact caccatgtag     1860

gtctcagaag agctggtgtt ttgtccagtc tgagtcctgt gaattcttcc aaccatggac     1920

cagtgtctac tggctctcta actaatcgat cacccataga atttcctgat actgctgatt     1980

ttcttaataa gccaagcgtt atcttgcaga gatctctggg caatgcacct aatactccag     2040

atttttatca gcaacttaga aattctgata gcaatctgtg taacagctgt ggacatcaaa     2100

tgctgaaata tgtttcaaca tctgaatcag atggtacaga ttgctgcagt ggaaaatcag     2160

gtgaagaaga aaacattttc tcgaaagaat cattcaaact tatggaaact caacaagaag     2220

aggaaacaga gaagaaagac agcagaaaat tatttcagga aggtgataag tggctaacag     2280

aagaggcaca gagtgaacag caaacaaata ttgaacagga agtatcactg gacctgattt     2340

tagtagaaga gtatgactca ttaatagaaa agatgagcaa ctggaatttt ccaatttttg     2400

aacttgtaga aaagatggga gagaaatcag gaaggattct cagtcaggtt atgtatacct     2460

tatttcaaga cactggttta ttggaaatat ttaaaattcc cactcaacaa tttatgaact     2520

attttcgtgc attagaaaat ggctatcgag acattcctta tcacaatcgt atacatgcca     2580

cagatgtgct acatgcagtt tggtatctga caacacggcc agttcctggc ttacagcaga     2640

tccacaatgg ttgtggaaca ggaaatgaaa cagattctga tggtagaatt aaccatgggc     2700

gaattgctta tatttcttcg aagagctgct ctaatcctga tgagagttat ggctgcctgt     2760

cttcaaacat tcctgcatta gaattgatgg ctctatacgt ggcagctgcc atgcatgatt     2820

atgatcaccc agggaggaca aatgcatttc tagtggctac aaatgcccct caggcagttt     2880

tatacaatga cagatctgtt ctggaaaatc atcatgctgc gtcagcttgg aatctatatc     2940

tttctcgccc agaatacaac ttccttcttc atcttgatca tgtggaattc aagcgctttc     3000

gttttttagt cattgaagca atccttgcta cggatcttaa aaagcatttt gattttctcg     3060

cagaattcaa tgccaaggca aatgatgtaa atagtaatgg catagaatgg agtaatgaaa     3120

atgatcgcct cttggtatgc caggtgtgca tcaaactggc agatataaat ggcccagcaa     3180

aagttcgaga cttgcatttg aaatggacag aaggcattgt caatgaattt tatgagcagg     3240

gagatgaaga agcaaatctt ggtctgccca tcagtccatt catggatcgt tcttctcctc     3300

aactagcaaa actccaagaa tcttttatca cccacatagt gggtcccctg tgtaactcct     3360

atgatgctgc tggtttgcta ccaggtcagt ggttagaagc agaagaggat aatgatactg     3420

aaagtggtga tgatgaagac ggtgaagaat tagatacaga agatgaagaa atggaaaaca     3480

atctaaatcc aaaaccacca agaaggaaaa gcagacggcg aatattttgt cagctaatgc     3540

accacctcac tgaaaaccac aagatatgga aggaaatcgt agaggaagaa gaaaaatgta     3600

aagctgatgg gaataaactg caggtggaga attcctcctt acctcaagca gatgagattc     3660

aggtaattga agaggcagat gaagaggaat agcgacagtt tgagtaaaag aaaagtcata     3720

ttgaagaagc ccagagggtt gtgcccaggg gcagaaatca ttgcctagtg ttcaccggct     3780

gactctcaac tgaccattcc catgtggaca ggccttaata ctgtgagagg atccttgctc     3840

tgctggcagt ttcccactcc tatgcacttt cacaggaact agaaaactat tcttaaacca     3900

aaaataccat ccgtgttgac ccatgttgca gagcccttac ttaaatcctt cactggtgta     3960

tgaatacttt gtcataatgc tgctttgctg ggtagtgagc tcttattttt cactgggggt     4020

cagctataac taaaaactca agtgacatat ttcagttacc aaagtggcca ggaacttttt     4080

gcttttatga aaatagattc atattgtatt tcccagtgtg tcttttatgt ctttgaatgt     4140

tttggagaaa agtctatgcc tgtctaaaaa tgaatccagt gttgcctttc tgagggattt     4200

ctgctcaatg caatacactg ttcagtgcta ttctcccagc taggtttatc catgaaggac     4260

tgagtgacct ttgttgtatt taacaaaatc caggtgcatc aatttctgat gctttttact     4320

attgtgtatt atctactatg tgtgttttat ttctgctgag agtattcagg tttgccatgg     4380

acatcagaag tttgaattcc agtcttatct tatgttccat ggctgaattt taaagctgtt     4440

taggtttaac aatgaaggga tttattcttt agtcaaaatt gttgttttta ctctagctca     4500

ggattcgtat ttttaaagat ttagttaata tgaacacagc acagatttgt tagaagaaaa     4560

aaaatttgct gtaataccaa aactaacctc atcaaagata cagaaaaaaa gaaatatagt     4620

gagccctaaa ggacacatac attgaataaa taattggaac atgtggttat ctttagatcc     4680

acatcttagc tgtcatttgt tcactctaaa actgatgttc atctttctgt taatttccct     4740

ctgcctaaag actacatgac agaaatgacc tatcactact tattatttct gaagcctaac     4800

tgcaagactg atttctgaga acaagtaaag aactggaata cttatttttc atataaaaat     4860

ctaaatgtgt taataaatca tttcatacaa aagtacatta ttaaataacc acattattaa     4920

aataattgca agaaaatgga ccatatttac aatgttttgt aaacttgcta gtgtgtggat     4980

atgtacccta cttgtgaaat acatttgaag atataaagag cagccaaaat gatggcaaaa     5040

tggtaggcta atattttcta ttattattgg agaacatatc atattttgga atcatgcaat     5100

tttgcacaca gtgaaaccat taattttcca aggtaattcc tttagaatat ggtattggca     5160

tgcagtttct tacttatcta gaatatttgg cttatctgaa agatatcaat ttaagatctc     5220

tggaagtgtt agaatttttg atccttcaca gtgtcaatat ttaatgaatc actaagcttt     5280

atttattaga cgtgttgagt gagtgctgag ttccttgctg ccacttttgt taccattgtc     5340

acacactatg tgtaaaccag tcccaccact tattactaat aaaattttga ctgataattt     5400

atatttgcac ttacaatata tatatcctgt ccttatattt ctctagagta cattttccat     5460

catgtttaag tgtatttctg ctattatttc ctctcctgca gaatacatac aagtgtatgt     5520

gtataaagtc atacatgtac aagcatgcat attgagattg aatcacattt ccatactgtc     5580

tgttatttta ttgggtttta tattgggttt ctttagttta tgttgttttc tcaaaagcag     5640

cattttaaat tacgaatact ggacttattg gatttaatta taaatccaat tactactgga     5700

aactcatttt tacataatat agtccttaaa ttatttaacc cttgctaagt aattgacata     5760

tgtaacaata actagcctaa agaaacccaa aaaagtatct ctcccgagct gaaacttaaa     5820

aattcgtaag tgtaagaaag aatgtgagaa tatattaaat gcacactgta ccattagatg     5880

aaatcttact tgagaaattg ccataagcca tattacagat cttactttgt tactgaatca     5940

gattaatttc ttgttataat aattttcatc ataaattttc tatttttaaa gccgctggta     6000

ctagaaatat tcttttaatg ctatatctat gtacctactg acacattttt ctccataaaa     6060

gtacttttaa aaattacttc atgatttgaa a                                    6091


<210>  803
<211>  1112
<212>  PRT
<213>  Homo Sapiens

<400>  803

Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      


Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          


Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              


Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  


Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  


Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      


Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         


Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             


Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 


Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 


Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     


Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         


Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             


Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 


Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 


Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     


Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         


Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             


Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 


Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 


Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     


Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         


Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             


Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 


Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 


Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     


Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         


Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             


Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 


His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 


Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     


Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         


Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             


Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 


Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 


Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     


Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         


Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             


Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 


Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 


Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     


Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         


Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             


Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 


Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 


Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     


His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         


Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             


Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 


Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 


Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     


Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         


Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             


Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 


Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 


Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     


Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         


Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             


Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 


Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 


Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     


Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         


Thr His Ile Val Gly Pro Leu Cys  Asn Ser Tyr Asp Ala  Ala Gly Leu 
        995                 1000                 1005             


Leu Pro  Gly Gln Trp Leu Glu  Ala Glu Glu Asp Asn  Asp Thr Glu 
    1010                 1015                 1020             


Ser Gly  Asp Asp Glu Asp Gly  Glu Glu Leu Asp Thr  Glu Asp Glu 
    1025                 1030                 1035             


Glu Met  Glu Asn Asn Leu Asn  Pro Lys Pro Pro Arg  Arg Lys Ser 
    1040                 1045                 1050             


Arg Arg  Arg Ile Phe Cys Gln  Leu Met His His Leu  Thr Glu Asn 
    1055                 1060                 1065             


His Lys  Ile Trp Lys Glu Ile  Val Glu Glu Glu Glu  Lys Cys Lys 
    1070                 1075                 1080             


Ala Asp  Gly Asn Lys Leu Gln  Val Glu Asn Ser Ser  Leu Pro Gln 
    1085                 1090                 1095             


Ala Asp  Glu Ile Gln Val Ile  Glu Glu Ala Asp Glu  Glu Glu 
    1100                 1105                 1110         


<210>  804
<211>  2625
<212>  DNA
<213>  Homo Sapiens

<400>  804
acgcctcgtc tcctcccgtg tccctcttcc catggagtca gtacggatcg aacagatgct       60

gagcttgccc gctgaggtca gcagcgacaa cttggagtcg gcggagcgag gggcatcagc      120

ggcccaagta gacatgggcc cccacccaaa ggtggctgca gagggccccg cacctctacc      180

gacgcgggag ccagagcaag agcagtctcc ggggacctca acgccggaga gcaaagtcct      240

gctcacgcag gcagacgcct tggcgtcccg ggggcgaatc cgtgaagccc tcgaggtgta      300

tagacagctc tccgagcggc agcagctggt ggctgagcag ctggagcagc tggtgcgctg      360

cctggcggag aaagtcccgc aaggcgaggc gctggcgccg gcgcccccgg acgagggtag      420

cactgcaagc ggcaccgtgg cggcggaaga gacgggggcc gccgcggctg cggcggccac      480

cgaggtgtgg gacggcttta agtgccggaa atgtcatggg tttctatcag accccgtgtc      540

cttgtcgtgt ggccacacct tttgtaaact gtgcctggaa cgtgggcggg ccgccgaccg      600

gcgctgtgcg ctgtgcgggg tcaagctctc cgccttgatg gtggccactg ggcgggcgcg      660

tggagcccgg cgggctgggc agcagccgcc gccgccgctg cgagtcaacg tggtgctcag      720

cggcctcctc ggcaagttgt ttccaggccc agcgcgagcg tcgcaactcc ggcacgaggg      780

caaccgactg taccgcgagc gccaggtgga ggcggcactg ctcaagtaca acgaggcagt      840

taagttggct ccaaatgacc acttgcttta tagcaatcgg tctcagattt atttcacctt      900

ggagtctcat gagaatgcac tgcatgatgc agaaatagca tgtaagctcc gcccgatggg      960

ttttaaggca catttcagaa aagcccaagc cttagccacc ctaggcaagg tggaggaggc     1020

actaagggag tttctctact gtgtatccct tgatggaaag aacaagagag caagatgtga     1080

agcccaaaga gacaatctgg agctcccaca ttgttctagt caggaggaag cagcagccag     1140

gggagatggc agcagtctga tggacccagc taaagtgaag ggggatggtc agcagcacca     1200

catgaaagac caggaagaag aggaggagaa gtgggatgct acctctccaa aagctgcttc     1260

cagcaagact ggaaaatgcc aggaaaagaa aaggaaacat tgccagattg aatcccaaga     1320

agaaacgggg atgcctaata aagcctccaa gcaagatcct cccactgatc agggggacaa     1380

acctgctctc agtttaccac ttgcatcttt cgacgcatct gaccttgaat gcgctctatg     1440

tatgagatta ttctatgagc cagtcacaac accttgcggg catacttttt gcttaaaatg     1500

cctagaaaga tgcctagatc acaacgcaaa gtgtccattg tgcaaagacg gtctttcaca     1560

gtgcttggca tcaagaaaat acagcaaaaa tgtaataatg gaggagctca tagctaaatt     1620

ccttccagaa gaactgaagg aacgaaggaa gctttatgaa gaggaaatgg aagaactttc     1680

taaccttaat aagaatgtgc ctattttcgt gtgtactatg gcctatccca ccgttccttg     1740

tcccctgcac atctttgagc cttgttaccg cctgatgatt cgtagatgca ttgagacagg     1800

cacgagacag tttggcatgt gccttggaga tcctgtcaaa gggtttgcag aatatggctg     1860

catcctagag atcagaaatg ttcaattctt tgctgatggc cgctcagtgg ttgacagcat     1920

aggcaagagg cgcttcaggg tgctccatca gagccagcgg gatggctaca acacagccga     1980

cattgaatac attgaagacc aaaaggttca gggagaggat tgtgctgagc tcatgggatt     2040

acataactgt gtctatcagc aagcatcatt gtggtttcat tcgctcaaat tatccctaaa     2100

gaatcggata ctcaatcact ttggtcccat gccggagaaa gacgccgatc ctcagatgaa     2160

cccgaatggc ccagcctggt gctggtggat gttagcagtt cttcccttgg aaagccgagc     2220

tcagctcccc ttcctagcaa tgaggtcctt aaaggacaga ctgaatggta ttcgacgagt     2280

cctggccttc atatcccgaa accaaaacta gtgagtggat tgccgaagag gagctcccac     2340

cttccccact gccgtcgggg ggagtcttct tgtaaatata tctaattgca ataatatctt     2400

aacagaaggg ggtgtcaaac agaggcatca gcctgctgtt gatcacagag agaaattgag     2460

tagaaagacc aaaagaatgt gacctatttg aaactttctg tcttaagatg cttcttgaca     2520

tgctgcataa ctacataaac agcagaggtg tttaagagcc cagaaaaaca taatttgatt     2580

ttaacattaa aatttccaaa agtttaaaaa aaaaaaaaaa aaaaa                     2625


<210>  805
<211>  759
<212>  PRT
<213>  Homo Sapiens

<400>  805

Met Glu Ser Val Arg Ile Glu Gln Met Leu Ser Leu Pro Ala Glu Val 
1               5                   10                  15      


Ser Ser Asp Asn Leu Glu Ser Ala Glu Arg Gly Ala Ser Ala Ala Gln 
            20                  25                  30          


Val Asp Met Gly Pro His Pro Lys Val Ala Ala Glu Gly Pro Ala Pro 
        35                  40                  45              


Leu Pro Thr Arg Glu Pro Glu Gln Glu Gln Ser Pro Gly Thr Ser Thr 
    50                  55                  60                  


Pro Glu Ser Lys Val Leu Leu Thr Gln Ala Asp Ala Leu Ala Ser Arg 
65                  70                  75                  80  


Gly Arg Ile Arg Glu Ala Leu Glu Val Tyr Arg Gln Leu Ser Glu Arg 
                85                  90                  95      


Gln Gln Leu Val Ala Glu Gln Leu Glu Gln Leu Val Arg Cys Leu Ala 
            100                 105                 110         


Glu Lys Val Pro Gln Gly Glu Ala Leu Ala Pro Ala Pro Pro Asp Glu 
        115                 120                 125             


Gly Ser Thr Ala Ser Gly Thr Val Ala Ala Glu Glu Thr Gly Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Thr Glu Val Trp Asp Gly Phe Lys Cys Arg Lys 
145                 150                 155                 160 


Cys His Gly Phe Leu Ser Asp Pro Val Ser Leu Ser Cys Gly His Thr 
                165                 170                 175     


Phe Cys Lys Leu Cys Leu Glu Arg Gly Arg Ala Ala Asp Arg Arg Cys 
            180                 185                 190         


Ala Leu Cys Gly Val Lys Leu Ser Ala Leu Met Val Ala Thr Gly Arg 
        195                 200                 205             


Ala Arg Gly Ala Arg Arg Ala Gly Gln Gln Pro Pro Pro Pro Leu Arg 
    210                 215                 220                 


Val Asn Val Val Leu Ser Gly Leu Leu Gly Lys Leu Phe Pro Gly Pro 
225                 230                 235                 240 


Ala Arg Ala Ser Gln Leu Arg His Glu Gly Asn Arg Leu Tyr Arg Glu 
                245                 250                 255     


Arg Gln Val Glu Ala Ala Leu Leu Lys Tyr Asn Glu Ala Val Lys Leu 
            260                 265                 270         


Ala Pro Asn Asp His Leu Leu Tyr Ser Asn Arg Ser Gln Ile Tyr Phe 
        275                 280                 285             


Thr Leu Glu Ser His Glu Asn Ala Leu His Asp Ala Glu Ile Ala Cys 
    290                 295                 300                 


Lys Leu Arg Pro Met Gly Phe Lys Ala His Phe Arg Lys Ala Gln Ala 
305                 310                 315                 320 


Leu Ala Thr Leu Gly Lys Val Glu Glu Ala Leu Arg Glu Phe Leu Tyr 
                325                 330                 335     


Cys Val Ser Leu Asp Gly Lys Asn Lys Arg Ala Arg Cys Glu Ala Gln 
            340                 345                 350         


Arg Asp Asn Leu Glu Leu Pro His Cys Ser Ser Gln Glu Glu Ala Ala 
        355                 360                 365             


Ala Arg Gly Asp Gly Ser Ser Leu Met Asp Pro Ala Lys Val Lys Gly 
    370                 375                 380                 


Asp Gly Gln Gln His His Met Lys Asp Gln Glu Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Trp Asp Ala Thr Ser Pro Lys Ala Ala Ser Ser Lys Thr Gly Lys Cys 
                405                 410                 415     


Gln Glu Lys Lys Arg Lys His Cys Gln Ile Glu Ser Gln Glu Glu Thr 
            420                 425                 430         


Gly Met Pro Asn Lys Ala Ser Lys Gln Asp Pro Pro Thr Asp Gln Gly 
        435                 440                 445             


Asp Lys Pro Ala Leu Ser Leu Pro Leu Ala Ser Phe Asp Ala Ser Asp 
    450                 455                 460                 


Leu Glu Cys Ala Leu Cys Met Arg Leu Phe Tyr Glu Pro Val Thr Thr 
465                 470                 475                 480 


Pro Cys Gly His Thr Phe Cys Leu Lys Cys Leu Glu Arg Cys Leu Asp 
                485                 490                 495     


His Asn Ala Lys Cys Pro Leu Cys Lys Asp Gly Leu Ser Gln Cys Leu 
            500                 505                 510         


Ala Ser Arg Lys Tyr Ser Lys Asn Val Ile Met Glu Glu Leu Ile Ala 
        515                 520                 525             


Lys Phe Leu Pro Glu Glu Leu Lys Glu Arg Arg Lys Leu Tyr Glu Glu 
    530                 535                 540                 


Glu Met Glu Glu Leu Ser Asn Leu Asn Lys Asn Val Pro Ile Phe Val 
545                 550                 555                 560 


Cys Thr Met Ala Tyr Pro Thr Val Pro Cys Pro Leu His Ile Phe Glu 
                565                 570                 575     


Pro Cys Tyr Arg Leu Met Ile Arg Arg Cys Ile Glu Thr Gly Thr Arg 
            580                 585                 590         


Gln Phe Gly Met Cys Leu Gly Asp Pro Val Lys Gly Phe Ala Glu Tyr 
        595                 600                 605             


Gly Cys Ile Leu Glu Ile Arg Asn Val Gln Phe Phe Ala Asp Gly Arg 
    610                 615                 620                 


Ser Val Val Asp Ser Ile Gly Lys Arg Arg Phe Arg Val Leu His Gln 
625                 630                 635                 640 


Ser Gln Arg Asp Gly Tyr Asn Thr Ala Asp Ile Glu Tyr Ile Glu Asp 
                645                 650                 655     


Gln Lys Val Gln Gly Glu Asp Cys Ala Glu Leu Met Gly Leu His Asn 
            660                 665                 670         


Cys Val Tyr Gln Gln Ala Ser Leu Trp Phe His Ser Leu Lys Leu Ser 
        675                 680                 685             


Leu Lys Asn Arg Ile Leu Asn His Phe Gly Pro Met Pro Glu Lys Asp 
    690                 695                 700                 


Ala Asp Pro Gln Met Asn Pro Asn Gly Pro Ala Trp Cys Trp Trp Met 
705                 710                 715                 720 


Leu Ala Val Leu Pro Leu Glu Ser Arg Ala Gln Leu Pro Phe Leu Ala 
                725                 730                 735     


Met Arg Ser Leu Lys Asp Arg Leu Asn Gly Ile Arg Arg Val Leu Ala 
            740                 745                 750         


Phe Ile Ser Arg Asn Gln Asn 
        755                 


<210>  806
<211>  3265
<212>  DNA
<213>  Homo Sapiens

<400>  806
cgagggcgag gcggccacgc ggggccggga atgcccgcgg tgcggggccc cagagccgcc       60

cggtggtcgt gtccgggcga tggctcttcg cctggtcgcc gacttcgacc tcgggaagga      120

cgtgctcccg tggttgcggg cgcagcgggc agtgtcggag gccagcgggg ccggaagcgg      180

cggcgcagat gttttagaaa acgattatga gagcttacat gtattaaatg ttgaaagaaa      240

tggaaatatt atttatacct ataaggatga taagggaaat gtcgtctttg gattatatga      300

ttgtcaaacc agacaaaatg agcttctata tacctttgag aaagacttgc aagttttcag      360

ttgctctgtc aacagtgaaa ggactttgct tgctgcaagt ttagttcagt ctactaaaga      420

aggaaaaagg aacgaacttc aaccaggatc aaagtgcttg actttgttgg ttgaaatcca      480

ccctgttaac aatgtgaagg ttctaaaggc tgtggatagc tatatttggg ttcagtttct      540

ctacccacat attgaaagtc atcctcttcc agagaaccat ctgttactga tttcagaaga      600

gaaatatatt gaacaatttc gtatccatgt cgcccaagaa gatggaaata gagtggtgat      660

taaaaattct ggccatctcc caagagacag aatagctgag gatttcgttt gggctcagtg      720

ggatatgtca gaacagagat tatattacat tgacctgaag aaatcaagga gtatcttaaa      780

atgtatccag ttttatgctg atgagagcta taacttaatg tttgaagtac ccttggacat      840

atcattaagc aactcaggat ttaaacttgt caactttgga tgtgattatc atcaataccg      900

agataaattt tccaaacacc tgactctgtg tgtttttacc aaccatacag gaagtttgtg      960

tgtatgttac agcccgaagt gtgcctcttg gggacaaatc acatattcag tgttttacat     1020

tcataaagga cacagcaaga ccttcaccac ttctcttgag aatgttgggt cacacatgac     1080

aaagggcatt acttttctca accttgacta ttatgtggct gtttacttac ctggtcattt     1140

cttccaccta cttaatgttc aacatccaga cctgatctgc cacaatctct ttctgacagg     1200

aaataatgaa atgattgata tgctacctca ttgcccttta cagtcattgt cagggtccct     1260

ggtattggat tgttgttctg gaaagctcta tagagcactg ctcagccagt cgtctttatt     1320

acagcttctg cagaacactt gcttagactg tgagaagatg gctgcgttgc actgcgcgct     1380

ctactgcggt caaggtgcgc agttcctgga agcccagatt attcagtgga tttctgagaa     1440

tgtctctgcc tgccattcat ttgacctcat tcaggaattt ataattgctt cttcatactg     1500

gagtgtatat tcagagacaa gtaacatgga caaactattg ccacattcct cagtgctcac     1560

ttggaataca gaaattcctg gaataactct tgtgacagaa gacattgcat tgcctcttat     1620

gaaggtgctc agctttaagg gctactggga aaaactgaac tccaacctag aatatgttaa     1680

gtacgccaag ccacacttcc actataacaa cagtgtggtc aggagagagt ggcacaacct     1740

gatctctgaa gagaaaacag gaaaaagaag gtctgcggca tacgtgagga atattcttga     1800

taatgcagta aaggtgattt ctaacctaga agcaagaaat ttggggccaa gattaacacc     1860

cctcctgcag gaggaagaca gccaccagcg gctgctcatg gggctgatgg tgtctgagct     1920

aaaagaccat tttttgagac acctacaggg tgtagaaaag aagaaaattg aacagatggt     1980

tctggactac atttcaaaac tgctggatct catttgccac atcgtagaaa ccaattggag     2040

gaaacataat cttcattcct gggttctcca cttcaatagt cgtggcagtg ctgctgaatt     2100

tgcagttttt cacatcatga ccaggattct ggaagctaca aacagtttgt ttttacctct     2160

gcctcctggt tttcatactc tgcacaccat cctcggggtc cagtgtctcc ctttgcataa     2220

cctgctgcat tgcattgaca gtggagtgtt gcttctcact gaaacagctg tcataaggct     2280

catgaaagat ctggataata cagagaaaaa tgaaaaactg aaattcagta tcattgtgcg     2340

gcttcctccg cttattgggc agaagatttg tagactttgg gatcatccta tgagttctaa     2400

catcatttcg cggaaccacg tgacgcgact gcttcagaac tataagaaac agcctcggaa     2460

ttctatgatt aacaagtcat cgttcagtgt agaatttctg cctctgaact acttcattga     2520

aattctgaca gatatagagt cctccaatca agccctgtat ccttttgaag gacatgacaa     2580

tgtggatgca gaatttgtag aggaagcagc tctgaaacac accgcgatgc ttttaggctt     2640

atgaaaaaga aaacgcaatt ggatctgctg ctgccatttt aatcttgctc attaacctta     2700

ctcctttgag aattctttaa caatatttaa aattggtaac aaaaatagtt tagccataat     2760

tgtttagcca tgtgagtttc aggttggtac acgttcagac agaactgctg tatcacattc     2820

caattttgaa tagccagtga gcaatcaagt gtagagaaat gataaatggc ctaagaaggc     2880

atacagtggc ataaacgatg ctcttcctag tagcttaata ggccacaagc tagtttctgt     2940

tgcactctga aataaaatat gctttaaaaa tgtagggaac agtgcttaga aaagcaaaaa     3000

ctaggtgtgt cattgaaata ataggcataa aaattaaatg ttacataaga acactatttg     3060

gaaagagggt ccttttaaaa actgaatttg tactaaatca gatttgccat gtccagtaca     3120

gaataatttg tacttagtat ttgcagcagg gtttgtcttt gtgaattcag atgaaacata     3180

tttatttttt tttatttata aaaggttgat ttaggaatat tttgtcagtc attaaaaaac     3240

ctgaaaacat aaaaaaaaaa aaaaa                                           3265


<210>  807
<211>  854
<212>  PRT
<213>  Homo Sapiens

<400>  807

Met Ala Leu Arg Leu Val Ala Asp Phe Asp Leu Gly Lys Asp Val Leu 
1               5                   10                  15      


Pro Trp Leu Arg Ala Gln Arg Ala Val Ser Glu Ala Ser Gly Ala Gly 
            20                  25                  30          


Ser Gly Gly Ala Asp Val Leu Glu Asn Asp Tyr Glu Ser Leu His Val 
        35                  40                  45              


Leu Asn Val Glu Arg Asn Gly Asn Ile Ile Tyr Thr Tyr Lys Asp Asp 
    50                  55                  60                  


Lys Gly Asn Val Val Phe Gly Leu Tyr Asp Cys Gln Thr Arg Gln Asn 
65                  70                  75                  80  


Glu Leu Leu Tyr Thr Phe Glu Lys Asp Leu Gln Val Phe Ser Cys Ser 
                85                  90                  95      


Val Asn Ser Glu Arg Thr Leu Leu Ala Ala Ser Leu Val Gln Ser Thr 
            100                 105                 110         


Lys Glu Gly Lys Arg Asn Glu Leu Gln Pro Gly Ser Lys Cys Leu Thr 
        115                 120                 125             


Leu Leu Val Glu Ile His Pro Val Asn Asn Val Lys Val Leu Lys Ala 
    130                 135                 140                 


Val Asp Ser Tyr Ile Trp Val Gln Phe Leu Tyr Pro His Ile Glu Ser 
145                 150                 155                 160 


His Pro Leu Pro Glu Asn His Leu Leu Leu Ile Ser Glu Glu Lys Tyr 
                165                 170                 175     


Ile Glu Gln Phe Arg Ile His Val Ala Gln Glu Asp Gly Asn Arg Val 
            180                 185                 190         


Val Ile Lys Asn Ser Gly His Leu Pro Arg Asp Arg Ile Ala Glu Asp 
        195                 200                 205             


Phe Val Trp Ala Gln Trp Asp Met Ser Glu Gln Arg Leu Tyr Tyr Ile 
    210                 215                 220                 


Asp Leu Lys Lys Ser Arg Ser Ile Leu Lys Cys Ile Gln Phe Tyr Ala 
225                 230                 235                 240 


Asp Glu Ser Tyr Asn Leu Met Phe Glu Val Pro Leu Asp Ile Ser Leu 
                245                 250                 255     


Ser Asn Ser Gly Phe Lys Leu Val Asn Phe Gly Cys Asp Tyr His Gln 
            260                 265                 270         


Tyr Arg Asp Lys Phe Ser Lys His Leu Thr Leu Cys Val Phe Thr Asn 
        275                 280                 285             


His Thr Gly Ser Leu Cys Val Cys Tyr Ser Pro Lys Cys Ala Ser Trp 
    290                 295                 300                 


Gly Gln Ile Thr Tyr Ser Val Phe Tyr Ile His Lys Gly His Ser Lys 
305                 310                 315                 320 


Thr Phe Thr Thr Ser Leu Glu Asn Val Gly Ser His Met Thr Lys Gly 
                325                 330                 335     


Ile Thr Phe Leu Asn Leu Asp Tyr Tyr Val Ala Val Tyr Leu Pro Gly 
            340                 345                 350         


His Phe Phe His Leu Leu Asn Val Gln His Pro Asp Leu Ile Cys His 
        355                 360                 365             


Asn Leu Phe Leu Thr Gly Asn Asn Glu Met Ile Asp Met Leu Pro His 
    370                 375                 380                 


Cys Pro Leu Gln Ser Leu Ser Gly Ser Leu Val Leu Asp Cys Cys Ser 
385                 390                 395                 400 


Gly Lys Leu Tyr Arg Ala Leu Leu Ser Gln Ser Ser Leu Leu Gln Leu 
                405                 410                 415     


Leu Gln Asn Thr Cys Leu Asp Cys Glu Lys Met Ala Ala Leu His Cys 
            420                 425                 430         


Ala Leu Tyr Cys Gly Gln Gly Ala Gln Phe Leu Glu Ala Gln Ile Ile 
        435                 440                 445             


Gln Trp Ile Ser Glu Asn Val Ser Ala Cys His Ser Phe Asp Leu Ile 
    450                 455                 460                 


Gln Glu Phe Ile Ile Ala Ser Ser Tyr Trp Ser Val Tyr Ser Glu Thr 
465                 470                 475                 480 


Ser Asn Met Asp Lys Leu Leu Pro His Ser Ser Val Leu Thr Trp Asn 
                485                 490                 495     


Thr Glu Ile Pro Gly Ile Thr Leu Val Thr Glu Asp Ile Ala Leu Pro 
            500                 505                 510         


Leu Met Lys Val Leu Ser Phe Lys Gly Tyr Trp Glu Lys Leu Asn Ser 
        515                 520                 525             


Asn Leu Glu Tyr Val Lys Tyr Ala Lys Pro His Phe His Tyr Asn Asn 
    530                 535                 540                 


Ser Val Val Arg Arg Glu Trp His Asn Leu Ile Ser Glu Glu Lys Thr 
545                 550                 555                 560 


Gly Lys Arg Arg Ser Ala Ala Tyr Val Arg Asn Ile Leu Asp Asn Ala 
                565                 570                 575     


Val Lys Val Ile Ser Asn Leu Glu Ala Arg Asn Leu Gly Pro Arg Leu 
            580                 585                 590         


Thr Pro Leu Leu Gln Glu Glu Asp Ser His Gln Arg Leu Leu Met Gly 
        595                 600                 605             


Leu Met Val Ser Glu Leu Lys Asp His Phe Leu Arg His Leu Gln Gly 
    610                 615                 620                 


Val Glu Lys Lys Lys Ile Glu Gln Met Val Leu Asp Tyr Ile Ser Lys 
625                 630                 635                 640 


Leu Leu Asp Leu Ile Cys His Ile Val Glu Thr Asn Trp Arg Lys His 
                645                 650                 655     


Asn Leu His Ser Trp Val Leu His Phe Asn Ser Arg Gly Ser Ala Ala 
            660                 665                 670         


Glu Phe Ala Val Phe His Ile Met Thr Arg Ile Leu Glu Ala Thr Asn 
        675                 680                 685             


Ser Leu Phe Leu Pro Leu Pro Pro Gly Phe His Thr Leu His Thr Ile 
    690                 695                 700                 


Leu Gly Val Gln Cys Leu Pro Leu His Asn Leu Leu His Cys Ile Asp 
705                 710                 715                 720 


Ser Gly Val Leu Leu Leu Thr Glu Thr Ala Val Ile Arg Leu Met Lys 
                725                 730                 735     


Asp Leu Asp Asn Thr Glu Lys Asn Glu Lys Leu Lys Phe Ser Ile Ile 
            740                 745                 750         


Val Arg Leu Pro Pro Leu Ile Gly Gln Lys Ile Cys Arg Leu Trp Asp 
        755                 760                 765             


His Pro Met Ser Ser Asn Ile Ile Ser Arg Asn His Val Thr Arg Leu 
    770                 775                 780                 


Leu Gln Asn Tyr Lys Lys Gln Pro Arg Asn Ser Met Ile Asn Lys Ser 
785                 790                 795                 800 


Ser Phe Ser Val Glu Phe Leu Pro Leu Asn Tyr Phe Ile Glu Ile Leu 
                805                 810                 815     


Thr Asp Ile Glu Ser Ser Asn Gln Ala Leu Tyr Pro Phe Glu Gly His 
            820                 825                 830         


Asp Asn Val Asp Ala Glu Phe Val Glu Glu Ala Ala Leu Lys His Thr 
        835                 840                 845             


Ala Met Leu Leu Gly Leu 
    850                 


<210>  808
<211>  3796
<212>  DNA
<213>  Homo Sapiens

<400>  808
ctggtctggc cggcgacgcg cgtgccctgt ggccaaacac tgcctggagt gagagcaaac       60

taccagcgca gtggggccgg cgcgagtgtg cgtgtgtgtg cgtgtgtgtg tgcgagcgcg      120

gtggaggggg gggaccaact gcttcacact ttcaacactg cactgaagag ggagagcgag      180

agagagactg gagacgcaca gatcccccca aggtctccca agcctaccgt cccacagatt      240

attgtacaga gccccaaaaa tcgaaacaga ggaaacgaac agcagttgaa catggacgaa      300

ggaattcctc atttgcaaga gagacagtta ctggaacata gagattttat aggactggac      360

tattcctctt tgtatatgtg taaacccaaa aggagcatga aacgagacga caccaaggat      420

acctacaaat taccgcacag attaatagaa aagaaaagaa gagaccgaat taatgaatgc      480

attgctcagc tgaaagattt actgcctgaa catctgaaat tgacaactct gggacatctg      540

gagaaagctg tagtcttgga attaactttg aaacacttaa aagctttaac cgccttaacc      600

gagcaacagc atcagaagat aattgcttta cagaatgggg agcgatctct gaaatcgccc      660

attcagtccg acttggatgc gttccactcg ggatttcaaa catgcgccaa agaagtcttg      720

caatacctct cccggtttga gagctggaca cccagggagc cgcggtgtgt ccagctgatc      780

aaccacttgc acgccgtggc cacccagttc ttgcccaccc cgcagctgtt gactcaacag      840

gtccctctga gcaaaggcac cggcgctccc tcggccgccg ggtccgcggc cgccccctgc      900

ctggagcgcg cggggcagaa gctggagccc ctcgcctact gcgtgcccgt catccagcgg      960

actcagccca gcgccgagct cgccgccgag aacgacacgg acaccgacag cggctacggc     1020

ggcgaagccg aggcccggcc ggaccgcgag aaaggcaaag gcgcgggggc gagccgcgtc     1080

accatcaagc aggagcctcc cggggaggac tcgccggcgc ccaagaggat gaagctggat     1140

tcccgcggcg gcggcagcgg cggcggcccg gggggcggcg cggcggcggc ggcagccgcg     1200

cttctggggc ccgaccctgc cgccgcggcc gcgctgctga gacccgacgc cgccctgctc     1260

agctcgctgg tggcgttcgg cggaggcgga ggcgcgccct tcccgcagcc cgcggccgcc     1320

gcggccccct tctgcctgcc cttctgcttc ctctcgcctt ctgcagctgc cgcctacgtg     1380

cagcccttcc tggacaagag cggcctggag aagtatctgt acccggcggc ggctgccgcc     1440

ccgttcccgc tgctataccc cggcatcccc gccccggcgg cagccgcggc agccgccgcc     1500

gccgctgccg ccgccgccgc cgcgttcccc tgcctgtcct cggtgttgtc gccccctccc     1560

gagaaggcgg gcgccgccgc cgcgaccctc ctgccgcacg aggtggcgcc ccttggggcg     1620

ccgcaccccc agcacccgca cggccgcacc cacctgccct tcgccgggcc ccgcgagccg     1680

gggaacccgg agagctctgc tcaggaagat ccctcgcagc caggaaagga agctccctga     1740

atccttgcgt cccgaaggac ggaggttcaa gcagagtgag aagttaaaat acccttaagg     1800

aggttcaagc agagtgagaa gttaaaatac ccttaaggtc tttaagggag gaagtgtaat     1860

agatgcacga caggcataaa caagaacaac aaaacaggtg ttatgtgtac attcggagtt     1920

cctgttttgc tcatcccgca ccaccccacc ctccacacac taacatccct ttcttccccc     1980

caccagctgt aaaagatcct atgcgaaaga cactggctct tttttttaat cccccaaata     2040

aattttgccc ccttttaggc catgttccat tatctcttaa aattggaacc taattcgaga     2100

ggaagtaaga agggtctgtt ctgtggctga gctaggtgaa ccccggggta ggggaaagat     2160

gttaacacct ttgacgtctt tggagttgac atggaacagc aggtagttgt tatgtagagc     2220

tagttctcaa agctgccctg cctgttttag gaggcgttcc acaaacagat tgaggctctt     2280

ttagaattga atttactctt cagtattttc taatgttcag ctttctaaaa ggcatatatt     2340

tttcaaagaa gtgaggatgc agtttctcac gttgcaacct attctgaagt ggtttaaatg     2400

gtatctctta gtaacttgca ctcgttaaag aaacacggag ctgggccatc gtcagaacta     2460

agtcagggaa ggagatggat gagaaggcca gaatcattcc tagtacattt gctaacactt     2520

tattgagaaa ttgaccatga attaatggac tcatcttaat ttcttctaag tccatatata     2580

gatagatatc tatctgtaca gatttctatt tatccataga taggtatcta tacatacaca     2640

tctcaagtgc atctattccc actctcatta atccatcatg ttcctaaatt tttgtaatct     2700

tactgtaaaa aaaagtgcac tgaacttcaa aacaaaacaa aaaacaacaa caacaaaaaa     2760

caagtccaaa ctgatatatc ctatattctg ttaaaattca aaagtgaacg aaagcattta     2820

actggccagt tttgattgca aatgctgtaa agatatagaa tgaagtcctg tgaggccttc     2880

ctatctccaa gtctatgtat tttctggaga ccaaaccaga taccagataa tcacaaagaa     2940

agctttttta ataaggctta aaccaagacc ttgtctagat atttttagtt tgttgccaag     3000

gtagcactgt gagaaatctc acttggatgt tatgtaaggg gtgagacaca acagtctgac     3060

tatgagtgag gaaaatatct gggtcttttc gtcagtttgg tgcatttgct gctgctgttg     3120

ctactgtttg cctcaaacgc tgtgtttaaa caacgttaaa ctcttagcct acaaggtggc     3180

tcttatgtac atagttgtta atacatccaa ttaatgatgt ctgacatgct atttttgtag     3240

ggagaaaata tgtgctaatg atattttgag ttaaaatatc ttttggggag gatttgctga     3300

aaagttgcac ttttgttaca atgcttatgc ttggtacaag cttatgctgt cttaaattat     3360

tttaaaaaaa taaatactgt ctgtgagaaa ccagctggtt tagaaaagtt tagtatgtga     3420

cgataaacta gaaattacct ttatattcta gtattttcag cactccataa attctattac     3480

ctaaatattg ccacactatt ttgtgattta aaaattctta ctaaggaata aaaactttaa     3540

tatacgatat gatattgtct aataattaaa aaagacataa tggatgctca attagtttta     3600

agatatctat aactataggg atacaaatca ctacagttct cagatttaca gctttttttt     3660

gtcattggct tgatgtcaca catttccaat ctcttgcaag cctccaggct ctggctttgt     3720

ctacctgctc gttcccaatg tatcttaatg aaaagtgcaa aagaaaaacc taccaattaa     3780

aaaaaaaaaa aaaaaa                                                     3796


<210>  809
<211>  482
<212>  PRT
<213>  Homo Sapiens

<400>  809

Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
1               5                   10                  15      


Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
            20                  25                  30          


Lys Arg Ser Met Lys Arg Asp Asp Thr Lys Asp Thr Tyr Lys Leu Pro 
        35                  40                  45              


His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
    50                  55                  60                  


Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Thr Thr Leu 
65                  70                  75                  80  


Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Thr Leu Lys His Leu 
                85                  90                  95      


Lys Ala Leu Thr Ala Leu Thr Glu Gln Gln His Gln Lys Ile Ile Ala 
            100                 105                 110         


Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Ile Gln Ser Asp Leu 
        115                 120                 125             


Asp Ala Phe His Ser Gly Phe Gln Thr Cys Ala Lys Glu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Ser Arg Phe Glu Ser Trp Thr Pro Arg Glu Pro Arg Cys Val 
145                 150                 155                 160 


Gln Leu Ile Asn His Leu His Ala Val Ala Thr Gln Phe Leu Pro Thr 
                165                 170                 175     


Pro Gln Leu Leu Thr Gln Gln Val Pro Leu Ser Lys Gly Thr Gly Ala 
            180                 185                 190         


Pro Ser Ala Ala Gly Ser Ala Ala Ala Pro Cys Leu Glu Arg Ala Gly 
        195                 200                 205             


Gln Lys Leu Glu Pro Leu Ala Tyr Cys Val Pro Val Ile Gln Arg Thr 
    210                 215                 220                 


Gln Pro Ser Ala Glu Leu Ala Ala Glu Asn Asp Thr Asp Thr Asp Ser 
225                 230                 235                 240 


Gly Tyr Gly Gly Glu Ala Glu Ala Arg Pro Asp Arg Glu Lys Gly Lys 
                245                 250                 255     


Gly Ala Gly Ala Ser Arg Val Thr Ile Lys Gln Glu Pro Pro Gly Glu 
            260                 265                 270         


Asp Ser Pro Ala Pro Lys Arg Met Lys Leu Asp Ser Arg Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Leu 
    290                 295                 300                 


Leu Gly Pro Asp Pro Ala Ala Ala Ala Ala Leu Leu Arg Pro Asp Ala 
305                 310                 315                 320 


Ala Leu Leu Ser Ser Leu Val Ala Phe Gly Gly Gly Gly Gly Ala Pro 
                325                 330                 335     


Phe Pro Gln Pro Ala Ala Ala Ala Ala Pro Phe Cys Leu Pro Phe Cys 
            340                 345                 350         


Phe Leu Ser Pro Ser Ala Ala Ala Ala Tyr Val Gln Pro Phe Leu Asp 
        355                 360                 365             


Lys Ser Gly Leu Glu Lys Tyr Leu Tyr Pro Ala Ala Ala Ala Ala Pro 
    370                 375                 380                 


Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Pro Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser 
                405                 410                 415     


Ser Val Leu Ser Pro Pro Pro Glu Lys Ala Gly Ala Ala Ala Ala Thr 
            420                 425                 430         


Leu Leu Pro His Glu Val Ala Pro Leu Gly Ala Pro His Pro Gln His 
        435                 440                 445             


Pro His Gly Arg Thr His Leu Pro Phe Ala Gly Pro Arg Glu Pro Gly 
    450                 455                 460                 


Asn Pro Glu Ser Ser Ala Gln Glu Asp Pro Ser Gln Pro Gly Lys Glu 
465                 470                 475                 480 


Ala Pro 
        


<210>  810
<211>  11650
<212>  DNA
<213>  Homo Sapiens

<400>  810
atggtggccc tgtccttaaa gatttgtgtg cgccactgca acgtggtgaa gaccatgcag       60

tttgaaccat ctacagctgt gtacgatgcg tgtcgagtca ttcgggaacg ggtgcctgag      120

gcacaaactg ggcaagcttc tgactatgga ctctttcttt cggatgaaga cccgaggaaa      180

gggatttggc tggaagcggg cagaacactg gattactaca tgttgcggaa tggggatatt      240

ttggaatata aaaagaaaca gagacctcag aaaatccgga tgctggatgg atctgtgaag      300

acagtgatgg tggatgattc caagactgtg ggggagctcc tggtcactat ttgtagcaga      360

ataggaataa caaattatga agaatactcc ttaatccaag aaactattga agaaaagaaa      420

gaggaaggaa cgggcacact caaaaaagac aggacactgt tacgagatga gaggaaaatg      480

gagaagttga aggccaagct gcacacagat gatgacctaa attggctgga tcacagccga      540

acattcagag aacaaggagt agatgaaaac gaaacgttgc tgcttagacg gaagttcttt      600

tactctgatc agaatgtaga ttcgagagac cccgtgcagc tgaacttgct ttatgttcag      660

gcacgggatg acatcctgaa tggctctcac cctgtctcct tcgagaaagc ttgtgagttt      720

ggtggatttc aagcccagat acaatttgga cctcatgtgg aacataaaca caaacctgga      780

tttttagatc tgaaggaatt cctgcccaaa gaatatatca agcagagagg agctgaaaag      840

aggatctttc aggagcataa gaactgcgga gagatgagtg agatagaagc caaggtcaag      900

tacgtcaaac tcgcacggtc cctccgcaca tatggcgtgt ccttcttcct ggtgaaggag      960

aagatgaaag gcaagaacaa gctggtgcct cgcctgctgg ggatcaccaa agactcggtg     1020

atgcgcgtgg atgagaagac caaggaagtg ctgcaggagt ggcccctcac caccgtcaag     1080

cgctgggcag cctcacccaa gagcttcaca ctggattttg gggagtatca ggaaagctac     1140

tattcagtac aaaccaccga gggagagcag atatcccagc tgattgcagg ctacattgac     1200

atcatcctga aaaagaaaca aagtaaagat cgatttggac tagaaggtga tgaggagtca     1260

accatgttag aagagtccgt ttccccaaaa aagtccacca tcttgcagca gcagttcaac     1320

cggaccggga aggcagagca cggctcagtg gcgctgccgg ccgtgatgcg ctcgggctcc     1380

agcgggcctg agaccttcaa cgttggcagc atgccctcgc cacagcagca ggtcatggtt     1440

gggcagatgc accgaggcca catgccgcca ctgacctcag cccagcaggc cctgatgggg     1500

accatcaaca caagcatgca cgccgtccag caggcccagg atgatctcag tgagctcgac     1560

tcgctgccac ctctcggcca ggatatggca tctagggtat gggttcagaa caaagtcgac     1620

gaatccaaac acgaaatcca ttctcaagtt gatgctatca cggccggaac ggcttcagtt     1680

gttaacctca cagctggtga ccctgcagac actgactaca cagctgtggg atgtgcgatc     1740

accactattt cttccaacct gacggagatg tccaagggtg tgaagctatt ggccgccctc     1800

atggatgatg aggtgggcag cggggaggac ttgctcagag ctgccaggac cctcgctggg     1860

gcggtgtcag acttgctgaa agctgtgcag cctacttctg gagagcctcg acagacagtt     1920

ttgactgctg ctggcagcat cggacaagcc agtggggatc ttctgagaca gattggagag     1980

aatgagactg atgagcgatt ccaggatgtt ttaatgagtt tggccaaagc tgttgccaat     2040

gcagctgcca tgttggtact aaaggcaaag aatgttgccc aagtggccga agacactgtc     2100

ctacagaaca gggtaattgc tgctgccacc cagtgtgccc tctccacctc ccagcttgtg     2160

gcatgtgcca aggttgtgag ccccactatt agctcccctg tgtgccagga gcagctgatt     2220

gaagcaggga agctggtgga ccgctcggtg gagaactgtg tccgtgcctg ccaggcggcc     2280

actaccgata gtgagctcct gaagcaggtc agcgcagcgg ccagcgtggt cagccaggcc     2340

ctccatgatc tcctgcagca tgtgcggcag tttgccagcc gaggcgagcc catcggccgc     2400

tacgaccagg ctactgacac catcatgtgt gtcaccgaga gcatcttcag ctccatgggt     2460

gacgctggtg aaatggtgcg ccaggcgcgg gttctggccc aagccacatc agacctcgtc     2520

aatgccatga ggtcagatgc agaagccgaa atcgacatgg agaattcaaa gaagctcctg     2580

gcagcagcaa aactcttagc tgactccact gctcgcatgg tggaagctgc aaagggggct     2640

gcagccaacc cagagaatga ggaccagcag caaaggctga gagaagctgc agaaggcctc     2700

cgggtagcaa ccaacgcagc tgcccagaat gctattaaga aaaaaattgt caaccgactg     2760

gaggttgcag ccaagcaggc cgcagcggca gccacacaga ccatcgccgc ctcccagaat     2820

gcagctgttt ccaacaagaa ccctgcggcc cagcagcagc tggtccagag ttgcaaggca     2880

gtggctgatc acatccctca gctggtccag ggagtgaggg ggagccaagc tcaagctgaa     2940

gacctgagtg cccagctggc tctcatcatc tccagccaga acttcctcca gcctggaagc     3000

aagatggtgt cctctgccaa agccgcagtg cccaccgtga gtgaccaggc cgcagccatg     3060

cagctgagcc agtgtgccaa gaacctggcc accagcttgg cggagctgcg taccgcctcg     3120

cagaaggccc atgaagcttg tggtccgatg gaaatcgatt cagctctgaa tacggtgcag     3180

acgcttaaga atgaactgca ggatgccaag atggcagccg tggagagcca gctgaagcca     3240

cttccagggg aaacgctgga aaaatgtgct caggacctgg gaagcacatc caaggcggtg     3300

ggctcctcca tggcacagct gctgacctgt gctgctcaag gcaacgaaca ctacacaggg     3360

gtggctgcta gagagacggc ccaagctctg aaaacactgg cccaggccgc ccgtggagtg     3420

gctgcatcga caaccgaccc cgcggccgcc catgccatgt tagattctgc tcgagacgtg     3480

atggagggct ccgccatgct cattcaagag gccaagcagg ccctgattgc acctggagat     3540

gcagagcgtc aacaaagact ggctcaggtg gctaaagccg tctcacactc cttgaataac     3600

tgcgtaaatt gcctccctgg gcagaaggat gtggacgtgg ccttgaagag catcggggag     3660

tccagcaaga agctgcttgt ggattcgcta cctccaagca cgaagccttt ccaggaagcc     3720

cagagtgaac tgaaccaggc agcagctgat ctgaaccagt ctgctgggga agtggtccat     3780

gccacccggg gccagagtgg agagttggct gcagcctctg gaaagttcag tgatgatttt     3840

gatgaattcc tcgatgctgg cattgagatg gctggccaag ctcagacaaa agaagaccag     3900

atccaagtga tagggaacct caagaatatc tcgatggcat ccagcaagct gctgttagct     3960

gccaagtctc tctctgtaga tccaggagct cccaatgcga aaaatctcct ggctgcagct     4020

gcaagagctg tgacagagag catcaatcaa ctcatcactc tgtgtaccca acaagctccg     4080

ggccagaaag agtgcgataa tgccctgcgg gagctcgaga ctgtgaaggg gatgttggac     4140

aatcctaatg aacctgttag tgacctctct tactttgact gcattgagag tgtgatggaa     4200

aactccaagg ttctgggtga atcgatggca gggatttcac agaatgccaa gaccggagac     4260

ctccctgcct ttggggaatg tgtggggatt gcatccaagg ctctctgtgg gctgacagag     4320

gctgcagccc aggctgcata cttggttggc atctctgatc caaacagcca ggcaggccac     4380

cagggcctgg tggaccccat ccagtttgcc agggctaacc aggccatcca gatggcatgc     4440

cagaacttgg tggaccctgg cagcagccca tcacaggtcc tgtcagccgc cacaattgtt     4500

gccaagcaca cgtcagcctt gtgcaatgcc tgccgcatcg cctcatccaa gacggccaac     4560

ccagtagcca agaggcactt cgtccagtca gccaaggaag tcgccaacag cactgccaac     4620

ctggtgaaga ccatcaaggc cctggatggg gatttctctg aagacaaccg caataagtgt     4680

cgcatcgcca ccgcaccctt gattgaagct gtggagaacc tgacagcgtt cgcctcaaac     4740

cctgagtttg tcagcattcc tgcccagatc agctccgagg gttcccaggc acaggaacca     4800

atcctggtct cagccaagac catgctggag agttcatcgt acctcattcg cactgcacgc     4860

tctctggcca tcaaccccaa agacccaccc acctggtctg tactggctgg acattcccat     4920

acagtgtccg actccatcaa gagtctcatc acttctatca gggacaaggc ccctggacag     4980

agggagtgtg attactccat cgatggcatc aaccggtgca tccgggacat cgagcaggcc     5040

tcgctggccg ccgtcagcca gagcctggcc acgagggacg acatctctgt ggaggccctg     5100

caggagcagc tgacttcggt ggtccaggaa atcggacacc ttatcgatcc catcgccaca     5160

gcggctcggg gagaagcagc tcagctggga cataaggtga cacaactggc aagctatttt     5220

gagcccttga tcttagccgc agttggtgtg gcctccaaga ttcttgatca tcagcagcag     5280

atgacggtgc tggaccagac caagactctc gcagagtctg ccttgcagat gttgtatgca     5340

gccaaagaag gtggcggaaa ccccaaggca caacacaccc atgacgccat cacagaggcc     5400

gcccagttga tgaaggaagc cgtggatgac atcatggtga cgctgaacga agctgccagt     5460

gaagtggggc tggttggggg catggtggac gccattgcag aagccatgag caagctggat     5520

gaaggcactc ctccagaacc aaagggaaca tttgtcgact atcagacgac tgtggttaaa     5580

tactccaaag ccattgcggt gacagctcag gaaatgatga ctaagtcggt tactaacccg     5640

gaggagttgg gaggactggc ttcacaaatg accagtgact atgggcacct ggctttccag     5700

ggccagatgg cagcagccac ggcggaacca gaggagatcg gattccagat tcgcactcgt     5760

gtgcaggacc tgggccacgg ctgtatcttc ctggtgcaga aggcaggggc cctccaggtc     5820

tgccccacag acagctacac caagagggag ctgatcgaat gcgcccgtgc cgtcacggaa     5880

aaggtctcct tggtgctctc ggctctccag gccgggaaca aaggaaccca ggcatgcatt     5940

acagccgcca ccgctgtgtc tgggatcatt gccgacctgg acaccaccat tatgtttgca     6000

acagcgggga cgctgaatgc agagaacagt gagaccttcg cagaccacag ggagaacatt     6060

ctcaagacgg ccaaggcctt ggtagaagac acgaaactac ttgtgtcagg agctgcgtcc     6120

actcctgaca agctggccca ggcggcccag tcctcagcag ccaccatcac ccagctcgca     6180

gaagtggtca agctgggggc agccagcctg ggctccgacg accccgagac ccaggtggtt     6240

ttgatcaatg ccatcaaaga tgtggccaag gccctttctg atctcatcag tgctaccaag     6300

ggagctgcca gcaagccagt ggacgaccct tccatgtacc agctcaaggg ggctgccaag     6360

gtgatggtga ccaatgtcac ctcgctcctc aagactgtaa aggcagtgga ggatgaggcc     6420

acccggggca ccagggcgct tgaggccaca attgaatgca taaagcagga gcttacggtg     6480

ttccagtcaa aagacgtacc tgaaaagaca tcatcacctg aagaatccat aaggatgacg     6540

aaaggcatca ccatggcaac agccaaagcc gtggcagctg ggaactcatg tagacaggag     6600

gacgtgattg ctactgccaa cctgagccgg aaagccgtgt cagatatgtt gacggcttgc     6660

aagcaagcat ccttccaccc cgatgtcagt gacgaggtga gaaccagagc cttgcgtttc     6720

gggacggagt gcacccttgg ctacttggac ctcctggagc acgtcttggt gattcttcag     6780

aaaccaaccc cagaattcaa gcagcagctg gccgctttct ccaagcgagt cgccggcgct     6840

gtgacagagc tcatccaggc ggcggaagcc atgaaaggaa cagagtgggt ggatccagaa     6900

gacccaactg tcattgcaga aacagagtta ctgggggctg cagcatccat cgaagctgct     6960

gctaagaagt tagagcaact gaagccaaga gcaaaaccaa aacaagcgga tgagaccctg     7020

gactttgagg aacagatctt ggaagctgct aaatccattg ctgctgccac aagcgccctg     7080

gtcaaatcgg cctcagcagc ccagagggag ctggtggccc aaggaaaggt gggctccatc     7140

cctgccaatg ctgcagacga cggacagtgg tcacaggggc tgatttctgc tgcccggatg     7200

gtggcggctg cgaccagcag tctctgtgag gcggccaatg cctccgttca gggacacgcc     7260

agcgaggaga agctcatctc atctgccaag caggtcgccg cttccacggc tcagctgctg     7320

gtggcctgca aggtgaaggc cgaccaggat tcagaggcca tgaggcggct acaggcggca     7380

ggaaatgctg tgaaaagagc ctcagacaat cttgtccgtg cagcccagaa ggcagctttt     7440

ggcaaagctg atgacgacga tgttgtagtg aaaaccaagt ttgtgggggg cattgctcag     7500

atcatcgccg cccaggaaga aatgctaaag aaagagcgag aactggaaga agcaaggaaa     7560

aaactggccc aaatccgcca gcagcagtat aagtttttac ccaccgagct gagggaagat     7620

gagggctaaa ggtgcgagcc cagatggcga gccccagggg atggccctgg ctgaactgga     7680

cagacagtgt tcctgagagg ctgggcactt agctggaaac cgcccacctc cctcccgggt     7740

gagcctggag ccctgcgtgc ttgttctcac atctctgtcc cgtcggcact ggctgcatga     7800

tcgtgatgtc acacggtaca atgtcctacc cacaactcct ctgccgcctc ccctcatgcc     7860

tcaccgtgtc tcaggagaga ggggtgcacg tttcatggac tgttaccaac aaagaaaagt     7920

cagtattatg ttgttctcag acactttggc ttttgttggt ccttctctta ggcctgctcc     7980

tggacctctt tatgatattg tgatagggaa aaaaatcatt gacgtcatag aatattcttc     8040

ttcctctcag gagaagacgg aagctggagt tggacatggt tcataaaagc cagaaacaca     8100

aacccgtgtg gactccggga gggtgactca ggtcctcctt ccatgtcttg agcactggct     8160

cacccagggg gtgaaaaatt cccgcccctg tttgcacgct ttcttgcctc cgtgtgtaag     8220

ctccttgtac aacccagacc catcttgtat tttgtggccc agaaaactga acgattattt     8280

tgttcctccg tagtccaaag ggcagagttg cggaaggccg tcggggcttg gtgagcaggg     8340

gctgtaatac agtctgtggg ctccttaccc tgcagaggct gtttcagctc acacagagtc     8400

atccacacaa acccacggct cccagttgac agtcagtgga atgctcgtct ccttagcgtc     8460

cagggtgggg attctgctgg aataaagagc ttcctcagtg actcatcttt aggtcccacg     8520

ctggtttctg tgccttcaga atggtcacaa gcccggattg gaaaggatct gcttacaaac     8580

ctgtcccctg tcctccaacc caaaacgcct ttttttctgt cttaatatcc agaaaatcta     8640

aatgcatcct aaaatcaatg tgaaccttta acaagatagt tttacttatt atcacataag     8700

acataagatg ttttcatttt ctggatgtca cacttccaga atttcatatt tttcccctct     8760

tttctttccc cttttcagag ccctcccata ggaagggaag ggcttgaatt tacccttaat     8820

ctgcaccttt agccaaggca gtgcatggaa gatgaatggc tcgtgggaca gaatctaatg     8880

ccagggagca ggagtgtttg aaagaattca tagtggggaa ggtaaaagtt aatggaagta     8940

catgattttc aaaactggta acagttaaag gcactcaccc tccgcctctc tctctctctc     9000

tctctctggt gtgctatcat gtcttggact ccatccacac tatagtttca aagttccact     9060

gacgggggaa agttggtgct ttggtcctcc gaagatgtca cctttcgacc ttgcccgatc     9120

ttgtttcacc agactctagc ccatgtcatg gttttaaaat acataaactt ctgacagctt     9180

cccatattta taagttactt ataagtgctg cacgtattag aatttttttt tttcagacca     9240

gtaaagttag agaaaagacg ctgtaaagga aaagcaagtg agagtatgtg taggacactg     9300

acagtgtgtg ggcaccagtt ctgaagagga ggggagctgc tggagcccta gcctgttggg     9360

gaaaagctgg cacactcttg gctcgccctc tttgagtgga gctgatccaa cacctcatgc     9420

ctgccttggc cggacactga gaggaggggc acacgtgctt ccagagacac tcaggagtca     9480

gaccccaatg ctcagagtca caatgtgttc atggcctcct gtaacaggac tctggggatc     9540

ccctctgtgg cccagcccac cccaccctct gctcttctat gctgtgccca gggcagctgc     9600

cctcttctgc ctgtgcccca tcccatcctg aaaacccagg accaaggcag gggcaggcag     9660

ccagttcttc caccttgcct cagagtcatt taaaaccttt actgcatttg ataccagaaa     9720

agcctccaga gacaaaccaa atgcaaaggc ctttccttta taactctaaa gaacaggcat     9780

cgaaagttta tttttgtagg agctatataa atactcacct ttctggagtc gtccagtgct     9840

gggagctttg gggagtttgg ttctcagtta tcacctggta tggtcccagt ttctcatctg     9900

tcctttcctc atccaccctg cacatgtgta tgtgaacggc ttcgtggccg gtgtggtggt     9960

ttctcatttc ataagatagt tgaagggcca tgccttgtct ggatgttatt taataggcac    10020

tactgcggtg tcctcagatg gtactgaggg ggccttctgg tccttcaaag gaaaataaca    10080

caggcatgag ttcatttggg agtgtgaact ttcagaacac ctaataagag agtggtgtca    10140

gagtaaaaac ggccccaggt ctggagcata gaagtgtatc tctgtgaaga gagagccggt    10200

gtgttgacat gtggttcttc tcacacccct ctactcctcg agggctttga atccttgggc    10260

tgatttttgt gccagaaatt gctgttcccg atggccaaaa ggggaacctg aactggattt    10320

cagaactgcc cagtgatttg aaaatttaga ttttacttgg gcctttcagg agtctttaga    10380

tagggatgct gaggtcatat ttagttcaat gaacagccct tgtttaagtt ttgccagtgt    10440

ccagccagct gtggccctgg ccatctgtgc aggcaggttc ctcaattcct ggttggccct    10500

gcagtcggtc aacacagtcc ctccaggtcg gctgcagagg cagctgccca gcctgcagtc    10560

tatgcacggg ccttaagaaa tgagctgcct gtagcctcac ggcatatgct tttatcaggg    10620

aaaacccttc gagcttcttc tgattctcac ctgcttgctt tctggctgtc ttagtcagtg    10680

tgtttacagg caactaaagc ctgttcctaa tttatcaaaa aattataacc aaaattcacc    10740

atagcctaag agagtaaacc ccacctccaa agtgatgcca aggccaaaac ctcatcaagg    10800

aaccagacac aggtcaaaag tggtgagcaa gccatggtct ctgctcctgg ggaactcaca    10860

cgctgacccc cgaggagcct tggtttcctc cctggcagat agtccccaga atcttctctc    10920

ccagctttga ggttctgggc tctggaaagg cctctgggat gctggcctta agatctcagc    10980

acagactatc agcatgttcc attctcagat tcctggagga aaggtaccct ctgttgacca    11040

aggggctggc tgcttctgag acttaccaac ccaagaaatt tggagacatt cccctcaggc    11100

taaaaggcag cggtccccag agttcagaaa gcaaaagatc ttgacaactg tgccagtagt    11160

ggctctggtc ctatctctcc acagtgctgg cctctgctgg ggaaggcatc tttcccaaag    11220

gtatccccaa gtaccatgtt gaaaatgtcc tcagtctgtt gctccatctt tctgagcctc    11280

tgcttggtat gtcatgttta tggtcactac ggatgagtgt gtgcagagtt tgggttgatt    11340

cttttaaatg ctacaaacaa gagctatttc ttttcaataa aaaaggtttg gattcggcct    11400

cttcctctga gcccacctcc cagccctcca gggagcatca gtgtacctga gtcactttgt    11460

ctgcatctct tcatcccaca aaacacgagg ctgggtctca ttcagcggcc tctcaccaac    11520

cttcaagatc cagaagaaaa caggaacgtt cagctctgcc ctgtgtcgta tctaatcaca    11580

tacattaatt tatctaacca cataagttat ttttttttat ttgccagaaa taaaccttta    11640

aaggaacaaa                                                           11650


<210>  811
<211>  2542
<212>  PRT
<213>  Homo Sapiens

<400>  811

Met Val Ala Leu Ser Leu Lys Ile Cys Val Arg His Cys Asn Val Val 
1               5                   10                  15      


Lys Thr Met Gln Phe Glu Pro Ser Thr Ala Val Tyr Asp Ala Cys Arg 
            20                  25                  30          


Val Ile Arg Glu Arg Val Pro Glu Ala Gln Thr Gly Gln Ala Ser Asp 
        35                  40                  45              


Tyr Gly Leu Phe Leu Ser Asp Glu Asp Pro Arg Lys Gly Ile Trp Leu 
    50                  55                  60                  


Glu Ala Gly Arg Thr Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Ile 
65                  70                  75                  80  


Leu Glu Tyr Lys Lys Lys Gln Arg Pro Gln Lys Ile Arg Met Leu Asp 
                85                  90                  95      


Gly Ser Val Lys Thr Val Met Val Asp Asp Ser Lys Thr Val Gly Glu 
            100                 105                 110         


Leu Leu Val Thr Ile Cys Ser Arg Ile Gly Ile Thr Asn Tyr Glu Glu 
        115                 120                 125             


Tyr Ser Leu Ile Gln Glu Thr Ile Glu Glu Lys Lys Glu Glu Gly Thr 
    130                 135                 140                 


Gly Thr Leu Lys Lys Asp Arg Thr Leu Leu Arg Asp Glu Arg Lys Met 
145                 150                 155                 160 


Glu Lys Leu Lys Ala Lys Leu His Thr Asp Asp Asp Leu Asn Trp Leu 
                165                 170                 175     


Asp His Ser Arg Thr Phe Arg Glu Gln Gly Val Asp Glu Asn Glu Thr 
            180                 185                 190         


Leu Leu Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser 
        195                 200                 205             


Arg Asp Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp 
    210                 215                 220                 


Ile Leu Asn Gly Ser His Pro Val Ser Phe Glu Lys Ala Cys Glu Phe 
225                 230                 235                 240 


Gly Gly Phe Gln Ala Gln Ile Gln Phe Gly Pro His Val Glu His Lys 
                245                 250                 255     


His Lys Pro Gly Phe Leu Asp Leu Lys Glu Phe Leu Pro Lys Glu Tyr 
            260                 265                 270         


Ile Lys Gln Arg Gly Ala Glu Lys Arg Ile Phe Gln Glu His Lys Asn 
        275                 280                 285             


Cys Gly Glu Met Ser Glu Ile Glu Ala Lys Val Lys Tyr Val Lys Leu 
    290                 295                 300                 


Ala Arg Ser Leu Arg Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu 
305                 310                 315                 320 


Lys Met Lys Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr 
                325                 330                 335     


Lys Asp Ser Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Leu Gln 
            340                 345                 350         


Glu Trp Pro Leu Thr Thr Val Lys Arg Trp Ala Ala Ser Pro Lys Ser 
        355                 360                 365             


Phe Thr Leu Asp Phe Gly Glu Tyr Gln Glu Ser Tyr Tyr Ser Val Gln 
    370                 375                 380                 


Thr Thr Glu Gly Glu Gln Ile Ser Gln Leu Ile Ala Gly Tyr Ile Asp 
385                 390                 395                 400 


Ile Ile Leu Lys Lys Lys Gln Ser Lys Asp Arg Phe Gly Leu Glu Gly 
                405                 410                 415     


Asp Glu Glu Ser Thr Met Leu Glu Glu Ser Val Ser Pro Lys Lys Ser 
            420                 425                 430         


Thr Ile Leu Gln Gln Gln Phe Asn Arg Thr Gly Lys Ala Glu His Gly 
        435                 440                 445             


Ser Val Ala Leu Pro Ala Val Met Arg Ser Gly Ser Ser Gly Pro Glu 
    450                 455                 460                 


Thr Phe Asn Val Gly Ser Met Pro Ser Pro Gln Gln Gln Val Met Val 
465                 470                 475                 480 


Gly Gln Met His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln 
                485                 490                 495     


Ala Leu Met Gly Thr Ile Asn Thr Ser Met His Ala Val Gln Gln Ala 
            500                 505                 510         


Gln Asp Asp Leu Ser Glu Leu Asp Ser Leu Pro Pro Leu Gly Gln Asp 
        515                 520                 525             


Met Ala Ser Arg Val Trp Val Gln Asn Lys Val Asp Glu Ser Lys His 
    530                 535                 540                 


Glu Ile His Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val 
545                 550                 555                 560 


Val Asn Leu Thr Ala Gly Asp Pro Ala Asp Thr Asp Tyr Thr Ala Val 
                565                 570                 575     


Gly Cys Ala Ile Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Lys 
            580                 585                 590         


Gly Val Lys Leu Leu Ala Ala Leu Met Asp Asp Glu Val Gly Ser Gly 
        595                 600                 605             


Glu Asp Leu Leu Arg Ala Ala Arg Thr Leu Ala Gly Ala Val Ser Asp 
    610                 615                 620                 


Leu Leu Lys Ala Val Gln Pro Thr Ser Gly Glu Pro Arg Gln Thr Val 
625                 630                 635                 640 


Leu Thr Ala Ala Gly Ser Ile Gly Gln Ala Ser Gly Asp Leu Leu Arg 
                645                 650                 655     


Gln Ile Gly Glu Asn Glu Thr Asp Glu Arg Phe Gln Asp Val Leu Met 
            660                 665                 670         


Ser Leu Ala Lys Ala Val Ala Asn Ala Ala Ala Met Leu Val Leu Lys 
        675                 680                 685             


Ala Lys Asn Val Ala Gln Val Ala Glu Asp Thr Val Leu Gln Asn Arg 
    690                 695                 700                 


Val Ile Ala Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val 
705                 710                 715                 720 


Ala Cys Ala Lys Val Val Ser Pro Thr Ile Ser Ser Pro Val Cys Gln 
                725                 730                 735     


Glu Gln Leu Ile Glu Ala Gly Lys Leu Val Asp Arg Ser Val Glu Asn 
            740                 745                 750         


Cys Val Arg Ala Cys Gln Ala Ala Thr Thr Asp Ser Glu Leu Leu Lys 
        755                 760                 765             


Gln Val Ser Ala Ala Ala Ser Val Val Ser Gln Ala Leu His Asp Leu 
    770                 775                 780                 


Leu Gln His Val Arg Gln Phe Ala Ser Arg Gly Glu Pro Ile Gly Arg 
785                 790                 795                 800 


Tyr Asp Gln Ala Thr Asp Thr Ile Met Cys Val Thr Glu Ser Ile Phe 
                805                 810                 815     


Ser Ser Met Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Val Leu 
            820                 825                 830         


Ala Gln Ala Thr Ser Asp Leu Val Asn Ala Met Arg Ser Asp Ala Glu 
        835                 840                 845             


Ala Glu Ile Asp Met Glu Asn Ser Lys Lys Leu Leu Ala Ala Ala Lys 
    850                 855                 860                 


Leu Leu Ala Asp Ser Thr Ala Arg Met Val Glu Ala Ala Lys Gly Ala 
865                 870                 875                 880 


Ala Ala Asn Pro Glu Asn Glu Asp Gln Gln Gln Arg Leu Arg Glu Ala 
                885                 890                 895     


Ala Glu Gly Leu Arg Val Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile 
            900                 905                 910         


Lys Lys Lys Ile Val Asn Arg Leu Glu Val Ala Ala Lys Gln Ala Ala 
        915                 920                 925             


Ala Ala Ala Thr Gln Thr Ile Ala Ala Ser Gln Asn Ala Ala Val Ser 
    930                 935                 940                 


Asn Lys Asn Pro Ala Ala Gln Gln Gln Leu Val Gln Ser Cys Lys Ala 
945                 950                 955                 960 


Val Ala Asp His Ile Pro Gln Leu Val Gln Gly Val Arg Gly Ser Gln 
                965                 970                 975     


Ala Gln Ala Glu Asp Leu Ser Ala Gln Leu Ala Leu Ile Ile Ser Ser 
            980                 985                 990         


Gln Asn Phe Leu Gln Pro Gly Ser  Lys Met Val Ser Ser  Ala Lys Ala 
        995                 1000                 1005             


Ala Val  Pro Thr Val Ser Asp  Gln Ala Ala Ala Met  Gln Leu Ser 
    1010                 1015                 1020             


Gln Cys  Ala Lys Asn Leu Ala  Thr Ser Leu Ala Glu  Leu Arg Thr 
    1025                 1030                 1035             


Ala Ser  Gln Lys Ala His Glu  Ala Cys Gly Pro Met  Glu Ile Asp 
    1040                 1045                 1050             


Ser Ala  Leu Asn Thr Val Gln  Thr Leu Lys Asn Glu  Leu Gln Asp 
    1055                 1060                 1065             


Ala Lys  Met Ala Ala Val Glu  Ser Gln Leu Lys Pro  Leu Pro Gly 
    1070                 1075                 1080             


Glu Thr  Leu Glu Lys Cys Ala  Gln Asp Leu Gly Ser  Thr Ser Lys 
    1085                 1090                 1095             


Ala Val  Gly Ser Ser Met Ala  Gln Leu Leu Thr Cys  Ala Ala Gln 
    1100                 1105                 1110             


Gly Asn  Glu His Tyr Thr Gly  Val Ala Ala Arg Glu  Thr Ala Gln 
    1115                 1120                 1125             


Ala Leu  Lys Thr Leu Ala Gln  Ala Ala Arg Gly Val  Ala Ala Ser 
    1130                 1135                 1140             


Thr Thr  Asp Pro Ala Ala Ala  His Ala Met Leu Asp  Ser Ala Arg 
    1145                 1150                 1155             


Asp Val  Met Glu Gly Ser Ala  Met Leu Ile Gln Glu  Ala Lys Gln 
    1160                 1165                 1170             


Ala Leu  Ile Ala Pro Gly Asp  Ala Glu Arg Gln Gln  Arg Leu Ala 
    1175                 1180                 1185             


Gln Val  Ala Lys Ala Val Ser  His Ser Leu Asn Asn  Cys Val Asn 
    1190                 1195                 1200             


Cys Leu  Pro Gly Gln Lys Asp  Val Asp Val Ala Leu  Lys Ser Ile 
    1205                 1210                 1215             


Gly Glu  Ser Ser Lys Lys Leu  Leu Val Asp Ser Leu  Pro Pro Ser 
    1220                 1225                 1230             


Thr Lys  Pro Phe Gln Glu Ala  Gln Ser Glu Leu Asn  Gln Ala Ala 
    1235                 1240                 1245             


Ala Asp  Leu Asn Gln Ser Ala  Gly Glu Val Val His  Ala Thr Arg 
    1250                 1255                 1260             


Gly Gln  Ser Gly Glu Leu Ala  Ala Ala Ser Gly Lys  Phe Ser Asp 
    1265                 1270                 1275             


Asp Phe  Asp Glu Phe Leu Asp  Ala Gly Ile Glu Met  Ala Gly Gln 
    1280                 1285                 1290             


Ala Gln  Thr Lys Glu Asp Gln  Ile Gln Val Ile Gly  Asn Leu Lys 
    1295                 1300                 1305             


Asn Ile  Ser Met Ala Ser Ser  Lys Leu Leu Leu Ala  Ala Lys Ser 
    1310                 1315                 1320             


Leu Ser  Val Asp Pro Gly Ala  Pro Asn Ala Lys Asn  Leu Leu Ala 
    1325                 1330                 1335             


Ala Ala  Ala Arg Ala Val Thr  Glu Ser Ile Asn Gln  Leu Ile Thr 
    1340                 1345                 1350             


Leu Cys  Thr Gln Gln Ala Pro  Gly Gln Lys Glu Cys  Asp Asn Ala 
    1355                 1360                 1365             


Leu Arg  Glu Leu Glu Thr Val  Lys Gly Met Leu Asp  Asn Pro Asn 
    1370                 1375                 1380             


Glu Pro  Val Ser Asp Leu Ser  Tyr Phe Asp Cys Ile  Glu Ser Val 
    1385                 1390                 1395             


Met Glu  Asn Ser Lys Val Leu  Gly Glu Ser Met Ala  Gly Ile Ser 
    1400                 1405                 1410             


Gln Asn  Ala Lys Thr Gly Asp  Leu Pro Ala Phe Gly  Glu Cys Val 
    1415                 1420                 1425             


Gly Ile  Ala Ser Lys Ala Leu  Cys Gly Leu Thr Glu  Ala Ala Ala 
    1430                 1435                 1440             


Gln Ala  Ala Tyr Leu Val Gly  Ile Ser Asp Pro Asn  Ser Gln Ala 
    1445                 1450                 1455             


Gly His  Gln Gly Leu Val Asp  Pro Ile Gln Phe Ala  Arg Ala Asn 
    1460                 1465                 1470             


Gln Ala  Ile Gln Met Ala Cys  Gln Asn Leu Val Asp  Pro Gly Ser 
    1475                 1480                 1485             


Ser Pro  Ser Gln Val Leu Ser  Ala Ala Thr Ile Val  Ala Lys His 
    1490                 1495                 1500             


Thr Ser  Ala Leu Cys Asn Ala  Cys Arg Ile Ala Ser  Ser Lys Thr 
    1505                 1510                 1515             


Ala Asn  Pro Val Ala Lys Arg  His Phe Val Gln Ser  Ala Lys Glu 
    1520                 1525                 1530             


Val Ala  Asn Ser Thr Ala Asn  Leu Val Lys Thr Ile  Lys Ala Leu 
    1535                 1540                 1545             


Asp Gly  Asp Phe Ser Glu Asp  Asn Arg Asn Lys Cys  Arg Ile Ala 
    1550                 1555                 1560             


Thr Ala  Pro Leu Ile Glu Ala  Val Glu Asn Leu Thr  Ala Phe Ala 
    1565                 1570                 1575             


Ser Asn  Pro Glu Phe Val Ser  Ile Pro Ala Gln Ile  Ser Ser Glu 
    1580                 1585                 1590             


Gly Ser  Gln Ala Gln Glu Pro  Ile Leu Val Ser Ala  Lys Thr Met 
    1595                 1600                 1605             


Leu Glu  Ser Ser Ser Tyr Leu  Ile Arg Thr Ala Arg  Ser Leu Ala 
    1610                 1615                 1620             


Ile Asn  Pro Lys Asp Pro Pro  Thr Trp Ser Val Leu  Ala Gly His 
    1625                 1630                 1635             


Ser His  Thr Val Ser Asp Ser  Ile Lys Ser Leu Ile  Thr Ser Ile 
    1640                 1645                 1650             


Arg Asp  Lys Ala Pro Gly Gln  Arg Glu Cys Asp Tyr  Ser Ile Asp 
    1655                 1660                 1665             


Gly Ile  Asn Arg Cys Ile Arg  Asp Ile Glu Gln Ala  Ser Leu Ala 
    1670                 1675                 1680             


Ala Val  Ser Gln Ser Leu Ala  Thr Arg Asp Asp Ile  Ser Val Glu 
    1685                 1690                 1695             


Ala Leu  Gln Glu Gln Leu Thr  Ser Val Val Gln Glu  Ile Gly His 
    1700                 1705                 1710             


Leu Ile  Asp Pro Ile Ala Thr  Ala Ala Arg Gly Glu  Ala Ala Gln 
    1715                 1720                 1725             


Leu Gly  His Lys Val Thr Gln  Leu Ala Ser Tyr Phe  Glu Pro Leu 
    1730                 1735                 1740             


Ile Leu  Ala Ala Val Gly Val  Ala Ser Lys Ile Leu  Asp His Gln 
    1745                 1750                 1755             


Gln Gln  Met Thr Val Leu Asp  Gln Thr Lys Thr Leu  Ala Glu Ser 
    1760                 1765                 1770             


Ala Leu  Gln Met Leu Tyr Ala  Ala Lys Glu Gly Gly  Gly Asn Pro 
    1775                 1780                 1785             


Lys Ala  Gln His Thr His Asp  Ala Ile Thr Glu Ala  Ala Gln Leu 
    1790                 1795                 1800             


Met Lys  Glu Ala Val Asp Asp  Ile Met Val Thr Leu  Asn Glu Ala 
    1805                 1810                 1815             


Ala Ser  Glu Val Gly Leu Val  Gly Gly Met Val Asp  Ala Ile Ala 
    1820                 1825                 1830             


Glu Ala  Met Ser Lys Leu Asp  Glu Gly Thr Pro Pro  Glu Pro Lys 
    1835                 1840                 1845             


Gly Thr  Phe Val Asp Tyr Gln  Thr Thr Val Val Lys  Tyr Ser Lys 
    1850                 1855                 1860             


Ala Ile  Ala Val Thr Ala Gln  Glu Met Met Thr Lys  Ser Val Thr 
    1865                 1870                 1875             


Asn Pro  Glu Glu Leu Gly Gly  Leu Ala Ser Gln Met  Thr Ser Asp 
    1880                 1885                 1890             


Tyr Gly  His Leu Ala Phe Gln  Gly Gln Met Ala Ala  Ala Thr Ala 
    1895                 1900                 1905             


Glu Pro  Glu Glu Ile Gly Phe  Gln Ile Arg Thr Arg  Val Gln Asp 
    1910                 1915                 1920             


Leu Gly  His Gly Cys Ile Phe  Leu Val Gln Lys Ala  Gly Ala Leu 
    1925                 1930                 1935             


Gln Val  Cys Pro Thr Asp Ser  Tyr Thr Lys Arg Glu  Leu Ile Glu 
    1940                 1945                 1950             


Cys Ala  Arg Ala Val Thr Glu  Lys Val Ser Leu Val  Leu Ser Ala 
    1955                 1960                 1965             


Leu Gln  Ala Gly Asn Lys Gly  Thr Gln Ala Cys Ile  Thr Ala Ala 
    1970                 1975                 1980             


Thr Ala  Val Ser Gly Ile Ile  Ala Asp Leu Asp Thr  Thr Ile Met 
    1985                 1990                 1995             


Phe Ala  Thr Ala Gly Thr Leu  Asn Ala Glu Asn Ser  Glu Thr Phe 
    2000                 2005                 2010             


Ala Asp  His Arg Glu Asn Ile  Leu Lys Thr Ala Lys  Ala Leu Val 
    2015                 2020                 2025             


Glu Asp  Thr Lys Leu Leu Val  Ser Gly Ala Ala Ser  Thr Pro Asp 
    2030                 2035                 2040             


Lys Leu  Ala Gln Ala Ala Gln  Ser Ser Ala Ala Thr  Ile Thr Gln 
    2045                 2050                 2055             


Leu Ala  Glu Val Val Lys Leu  Gly Ala Ala Ser Leu  Gly Ser Asp 
    2060                 2065                 2070             


Asp Pro  Glu Thr Gln Val Val  Leu Ile Asn Ala Ile  Lys Asp Val 
    2075                 2080                 2085             


Ala Lys  Ala Leu Ser Asp Leu  Ile Ser Ala Thr Lys  Gly Ala Ala 
    2090                 2095                 2100             


Ser Lys  Pro Val Asp Asp Pro  Ser Met Tyr Gln Leu  Lys Gly Ala 
    2105                 2110                 2115             


Ala Lys  Val Met Val Thr Asn  Val Thr Ser Leu Leu  Lys Thr Val 
    2120                 2125                 2130             


Lys Ala  Val Glu Asp Glu Ala  Thr Arg Gly Thr Arg  Ala Leu Glu 
    2135                 2140                 2145             


Ala Thr  Ile Glu Cys Ile Lys  Gln Glu Leu Thr Val  Phe Gln Ser 
    2150                 2155                 2160             


Lys Asp  Val Pro Glu Lys Thr  Ser Ser Pro Glu Glu  Ser Ile Arg 
    2165                 2170                 2175             


Met Thr  Lys Gly Ile Thr Met  Ala Thr Ala Lys Ala  Val Ala Ala 
    2180                 2185                 2190             


Gly Asn  Ser Cys Arg Gln Glu  Asp Val Ile Ala Thr  Ala Asn Leu 
    2195                 2200                 2205             


Ser Arg  Lys Ala Val Ser Asp  Met Leu Thr Ala Cys  Lys Gln Ala 
    2210                 2215                 2220             


Ser Phe  His Pro Asp Val Ser  Asp Glu Val Arg Thr  Arg Ala Leu 
    2225                 2230                 2235             


Arg Phe  Gly Thr Glu Cys Thr  Leu Gly Tyr Leu Asp  Leu Leu Glu 
    2240                 2245                 2250             


His Val  Leu Val Ile Leu Gln  Lys Pro Thr Pro Glu  Phe Lys Gln 
    2255                 2260                 2265             


Gln Leu  Ala Ala Phe Ser Lys  Arg Val Ala Gly Ala  Val Thr Glu 
    2270                 2275                 2280             


Leu Ile  Gln Ala Ala Glu Ala  Met Lys Gly Thr Glu  Trp Val Asp 
    2285                 2290                 2295             


Pro Glu  Asp Pro Thr Val Ile  Ala Glu Thr Glu Leu  Leu Gly Ala 
    2300                 2305                 2310             


Ala Ala  Ser Ile Glu Ala Ala  Ala Lys Lys Leu Glu  Gln Leu Lys 
    2315                 2320                 2325             


Pro Arg  Ala Lys Pro Lys Gln  Ala Asp Glu Thr Leu  Asp Phe Glu 
    2330                 2335                 2340             


Glu Gln  Ile Leu Glu Ala Ala  Lys Ser Ile Ala Ala  Ala Thr Ser 
    2345                 2350                 2355             


Ala Leu  Val Lys Ser Ala Ser  Ala Ala Gln Arg Glu  Leu Val Ala 
    2360                 2365                 2370             


Gln Gly  Lys Val Gly Ser Ile  Pro Ala Asn Ala Ala  Asp Asp Gly 
    2375                 2380                 2385             


Gln Trp  Ser Gln Gly Leu Ile  Ser Ala Ala Arg Met  Val Ala Ala 
    2390                 2395                 2400             


Ala Thr  Ser Ser Leu Cys Glu  Ala Ala Asn Ala Ser  Val Gln Gly 
    2405                 2410                 2415             


His Ala  Ser Glu Glu Lys Leu  Ile Ser Ser Ala Lys  Gln Val Ala 
    2420                 2425                 2430             


Ala Ser  Thr Ala Gln Leu Leu  Val Ala Cys Lys Val  Lys Ala Asp 
    2435                 2440                 2445             


Gln Asp  Ser Glu Ala Met Arg  Arg Leu Gln Ala Ala  Gly Asn Ala 
    2450                 2455                 2460             


Val Lys  Arg Ala Ser Asp Asn  Leu Val Arg Ala Ala  Gln Lys Ala 
    2465                 2470                 2475             


Ala Phe  Gly Lys Ala Asp Asp  Asp Asp Val Val Val  Lys Thr Lys 
    2480                 2485                 2490             


Phe Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Lys  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Thr  Glu Leu Arg 
    2525                 2530                 2535             


Glu Asp  Glu Gly 
    2540         


<210>  812
<211>  2230
<212>  DNA
<213>  Homo Sapiens

<400>  812
gtcacatgac cggctttaag caacatggcg gctgccgtgg tgcagcgccc gggctgagcg       60

acagcaagtg cagcgggctc ctaccccggg tgaggggtgg cctccgcgtg ggatcgtgcc      120

ctcttcagcc cgctcctgtc cccgacatca cgtgtattcc gcacgtcccc tccgcgctgt      180

gtgtctactg agacggggag gcgtgacagg gcccgggtcc cttctcagtg gtgctctgtg      240

cttcagggca agctccccgt ctccgggcgc acttccctcg cctgtgttcg gtccatcctc      300

ctttctccag cctcctcccc tcgcaggtgg gatcgtcggt gggaccggag cgcgggcggg      360

cgcggccccc cgggaccatg gccgggtccg acaccgcgcc cttcctcagc caggcggatg      420

acccggacga cgggccagtg cctggcaccc cggggttgcc agggtccacg gggaacccga      480

agtccgagga gcccgaggtc ccggaccagg aggggctgca gcgcatcacc ggcctgtctc      540

ccggccgttc ggctctcata gtggcggtgc tgtgctacat caatctcctg aactacatgg      600

accgcttcac cgtggctggc gtccttcccg acatcgagca gttcttcaac atcggggaca      660

gtagctctgg gctcatccag accgtgttca tctccagtta catggtgttg gcacctgtgt      720

ttggctacct gggtgacagg tacaatcgga agtatctcat gtgcgggggc attgccttct      780

ggtccctggt gacactgggg tcatccttca tccccggaga gcatttctgg ctgctcctcc      840

tgacccgggg cctggtgggg gtcggggagg ccagttattc caccatcgcg cccactctca      900

ttgccgacct ctttgtggcc gaccagcgga gccggatgct cagcatcttc tactttgcca      960

ttccggtggg cagtggtctg ggctacattg caggctccaa agtgaaggat atggctggag     1020

actggcactg ggctctgagg gtgacaccgg gtctaggagt ggtggccgtt ctgctgctgt     1080

tcctggtagt gcgggagccg ccaaggggag ccgtggagcg ccactcagat ttgccacccc     1140

tgaaccccac ctcgtggtgg gcagatctga gggctctggc aagaaatcct agtttcgtcc     1200

tgtcttccct gggcttcact gctgtggcct ttgtcacggg ctccctggct ctgtgggctc     1260

cggcattcct gctgcgttcc cgcgtggtcc ttggggagac cccaccctgc cttcccggag     1320

actcctgctc ttcctctgac agtctcatct ttggactcat cacctgcctg accggagtcc     1380

tgggtgtggg cctgggtgtg gagatcagcc gccggctccg ccactccaac ccccgggctg     1440

atcccctggt ctgtgccact ggcctcctgg gctctgcacc cttcctcttc ctgtcccttg     1500

cctgcgcccg tggtagcatc gtggccactt atattttcat cttcattgga gagaccctcc     1560

tgtccatgaa ctgggccatc gtggccgaca ttctgctgta cgtggtgatc cctacccgac     1620

gctccaccgc cgaggccttc cagatcgtgc tgtcccacct gctgggtgat gctgggagcc     1680

cctacctcat tggcctgatc tctgaccgcc tgcgccggaa ctggcccccc tccttcttgt     1740

ccgagttccg ggctctgcag ttctcgctca tgctctgcgc gtttgttggg gcactgggcg     1800

gcgcagcctt cctgggcacc gccatcttca ttgaggccga ccgccggcgg gcacagctgc     1860

acgtgcaggg cctgctgcac gaagcagggt ccacagacga ccggattgtg gtgccccagc     1920

ggggccgctc cacccgcgtg cccgtggcca gtgtgctcat ctgagaggct gccgctcacc     1980

tacctgcaca tctgccacag ctggccctgg gcccacccca cgaagggcct gggcctaacc     2040

ccttggcctg gcccagcttc cagagggacc ctgggccgtg tgccagctcc cagacactac     2100

ctgggtagct caggggagga ggtgggggtc caggaggggg atccctctcc acaggggcag     2160

ccccaagggc tcggtgctat ttgtaacgga ataaaatttg tagccagacc ccaaaaaaaa     2220

aaaaaaaaaa                                                            2230


<210>  813
<211>  528
<212>  PRT
<213>  Homo Sapiens

<400>  813

Met Ala Gly Ser Asp Thr Ala Pro Phe Leu Ser Gln Ala Asp Asp Pro 
1               5                   10                  15      


Asp Asp Gly Pro Val Pro Gly Thr Pro Gly Leu Pro Gly Ser Thr Gly 
            20                  25                  30          


Asn Pro Lys Ser Glu Glu Pro Glu Val Pro Asp Gln Glu Gly Leu Gln 
        35                  40                  45              


Arg Ile Thr Gly Leu Ser Pro Gly Arg Ser Ala Leu Ile Val Ala Val 
    50                  55                  60                  


Leu Cys Tyr Ile Asn Leu Leu Asn Tyr Met Asp Arg Phe Thr Val Ala 
65                  70                  75                  80  


Gly Val Leu Pro Asp Ile Glu Gln Phe Phe Asn Ile Gly Asp Ser Ser 
                85                  90                  95      


Ser Gly Leu Ile Gln Thr Val Phe Ile Ser Ser Tyr Met Val Leu Ala 
            100                 105                 110         


Pro Val Phe Gly Tyr Leu Gly Asp Arg Tyr Asn Arg Lys Tyr Leu Met 
        115                 120                 125             


Cys Gly Gly Ile Ala Phe Trp Ser Leu Val Thr Leu Gly Ser Ser Phe 
    130                 135                 140                 


Ile Pro Gly Glu His Phe Trp Leu Leu Leu Leu Thr Arg Gly Leu Val 
145                 150                 155                 160 


Gly Val Gly Glu Ala Ser Tyr Ser Thr Ile Ala Pro Thr Leu Ile Ala 
                165                 170                 175     


Asp Leu Phe Val Ala Asp Gln Arg Ser Arg Met Leu Ser Ile Phe Tyr 
            180                 185                 190         


Phe Ala Ile Pro Val Gly Ser Gly Leu Gly Tyr Ile Ala Gly Ser Lys 
        195                 200                 205             


Val Lys Asp Met Ala Gly Asp Trp His Trp Ala Leu Arg Val Thr Pro 
    210                 215                 220                 


Gly Leu Gly Val Val Ala Val Leu Leu Leu Phe Leu Val Val Arg Glu 
225                 230                 235                 240 


Pro Pro Arg Gly Ala Val Glu Arg His Ser Asp Leu Pro Pro Leu Asn 
                245                 250                 255     


Pro Thr Ser Trp Trp Ala Asp Leu Arg Ala Leu Ala Arg Asn Pro Ser 
            260                 265                 270         


Phe Val Leu Ser Ser Leu Gly Phe Thr Ala Val Ala Phe Val Thr Gly 
        275                 280                 285             


Ser Leu Ala Leu Trp Ala Pro Ala Phe Leu Leu Arg Ser Arg Val Val 
    290                 295                 300                 


Leu Gly Glu Thr Pro Pro Cys Leu Pro Gly Asp Ser Cys Ser Ser Ser 
305                 310                 315                 320 


Asp Ser Leu Ile Phe Gly Leu Ile Thr Cys Leu Thr Gly Val Leu Gly 
                325                 330                 335     


Val Gly Leu Gly Val Glu Ile Ser Arg Arg Leu Arg His Ser Asn Pro 
            340                 345                 350         


Arg Ala Asp Pro Leu Val Cys Ala Thr Gly Leu Leu Gly Ser Ala Pro 
        355                 360                 365             


Phe Leu Phe Leu Ser Leu Ala Cys Ala Arg Gly Ser Ile Val Ala Thr 
    370                 375                 380                 


Tyr Ile Phe Ile Phe Ile Gly Glu Thr Leu Leu Ser Met Asn Trp Ala 
385                 390                 395                 400 


Ile Val Ala Asp Ile Leu Leu Tyr Val Val Ile Pro Thr Arg Arg Ser 
                405                 410                 415     


Thr Ala Glu Ala Phe Gln Ile Val Leu Ser His Leu Leu Gly Asp Ala 
            420                 425                 430         


Gly Ser Pro Tyr Leu Ile Gly Leu Ile Ser Asp Arg Leu Arg Arg Asn 
        435                 440                 445             


Trp Pro Pro Ser Phe Leu Ser Glu Phe Arg Ala Leu Gln Phe Ser Leu 
    450                 455                 460                 


Met Leu Cys Ala Phe Val Gly Ala Leu Gly Gly Ala Ala Phe Leu Gly 
465                 470                 475                 480 


Thr Ala Ile Phe Ile Glu Ala Asp Arg Arg Arg Ala Gln Leu His Val 
                485                 490                 495     


Gln Gly Leu Leu His Glu Ala Gly Ser Thr Asp Asp Arg Ile Val Val 
            500                 505                 510         


Pro Gln Arg Gly Arg Ser Thr Arg Val Pro Val Ala Ser Val Leu Ile 
        515                 520                 525             


<210>  814
<211>  3507
<212>  DNA
<213>  Homo Sapiens

<400>  814
gaagccagac agctggctcg agcctctcct gctcagcacc atggctaaga cccctagtga       60

ccatctgctg tccaccctgg aggagctggt gccctatgac ttcgagaagt tcaagttcaa      120

gctgcagaac accagtgtgc agaaggagca ctccaggatc ccccggagcc agatccagag      180

agccaggccg gtgaagatgg ccactctgct ggtcacctac tatggggaag agtacgccgt      240

gcagctcacc ctgcaggtcc tgcgggccat caaccagcgc ctgctggccg aggagctcca      300

cagggcagcc attcaggaat attccacaca agaaaacggc acagatgatt ccgcagcgtc      360

cagctccctg ggggagaaca agcccaggag cctgaagact ccagaccacc ccgaggggaa      420

cgaggggaac ggccctcggc cgtacggggg cggagctgcc agcctgcggt gcagccagcc      480

cgaggccggg agggggctgt cgaggaagcc cctgagcaaa cgcagagaga aggcctcgga      540

gggcctggac gcgcagggca agcctcggac ccggagcccg gccctgccgg gcgggagaag      600

ccccggcccc tgcagggcgc tagagggggg ccaggccgag gtccggctgc gcagaaacgc      660

cagctccgcg gggaggctgc aggggctggc ggggggcgcc ccggggcaga aggagtgcag      720

gcccttcgaa gtgtacctgc cctcgggaaa gatgcgacct agaagccttg aggtcaccat      780

ttctacaggg gagaaggcgc ccgcaaatcc agaaattctc ctgactctag aggaaaagac      840

agctgcgaat ctggactcgg caacagaacc ccgggcaagg cccactccgg atggaggggc      900

atctgcggac ctgaaggaag gccctggaaa tccagaacat tcggtcaccg gaaggccacc      960

agacacggct gcgagtcccc gctgccacgc ccaggaagga gacccagttg acggtacctg     1020

tgtgcgtgat tcctgcagct tccccgaggc agtttctggg cacccccagg cctcaggcag     1080

ccgctcacct ggctgccccc ggtgccagga ctcccatgaa aggaagagcc cgggaagcct     1140

aagcccccag cccctgccac agtgtaagcg ccacctgaag caggtccagc tgctcttctg     1200

tgaggatcac gatgagccca tctgcctcat ctgcagtctg agtcaggagc accaaggcca     1260

ccgggtgcgc cccattgagg aggtcgccct ggaacacaag aagaaaattc agaagcagct     1320

ggagcatctg aagaagctga gaaaatcagg ggaggagcag cgatcctatg gggaggagaa     1380

ggcagtgagc tttctgaaac aaactgaagc gctgaagcag cgggtgcaga ggaagctgga     1440

gcaggtgtac tacttcctgg agcagcaaga gcatttcttt gtggcctcac tggaggacgt     1500

gggccagatg gttgggcaga tcaggaaggc atatgacacc cgcgtatccc aggacatcgc     1560

cctgctcgat gcgctgattg gggaactgga ggccaaggag tgccagtcag aatgggaact     1620

tctgcaggac attggagaca tcttgcacag ggctaagaca gtgcctgtcc ctgaaaagtg     1680

gaccactcct caagagataa aacaaaagat ccaactcctc caccagaagt cagagtttgt     1740

ggagaagagc acaaagtact tctcagaaac cctgcgttca gaaatggaaa tgttcaatgt     1800

tccagagctg attggcgctc aggcacatgc tgttaatgtg attctggatg cagaaaccgc     1860

ttaccccaac ctcatcttct ctgatgatct gaagagtgtt agacttggaa acaagtggga     1920

gaggctgcct gatggcccgc aaagatttga cagctgtatc attgttctgg gctctccgag     1980

tttcctctct ggccgccgtt actgggaggt ggaggttgga gacaagacag catggatcct     2040

gggagcctgc aagacatcca taagcaggaa agggaacatg actctgtcgc cagagaatgg     2100

ctactgggtg gtgataatga tgaaggaaaa tgagtaccag gcgtccagcg ttcccccgac     2160

ccgcctgcta ataaaggagc ctcccaagcg tgtgggcatc ttcgtggact acagagttgg     2220

aagcatctcc ttttacaatg tgacagccag atcccacatc tatacattcg ccagctgctc     2280

tttctctggg ccccttcaac ctatcttcag ccctgggaca cgtgatggag ggaagaacac     2340

agctcctctg actatctgtc cagtgggtgg tcaggggcct gactgaatgc ccaacactgc     2400

atctctcttc ctgcttctgg ccttgtatct tgcattcaca ctcaatagtc acggaatgcc     2460

gactaggtgc tagctgctat gggaaatgca aaaataacaa aatagttact gtgcccacgg     2520

agcctacccg attatagcag aggtaagtta ggaacgaaca tgttagtcaa tccgggtgaa     2580

gacatgtact gatgacacac catggatttc agaggaggaa gtacggagtc gttgcataat     2640

ccgcccctgg tgggtggcac tctcaggtgc tcctgaacag aagatttggc cctcattttc     2700

cctcagaacc ccacggcaag gatatatgtc cccttgttct ctctgcttct gtcttgagga     2760

tatgggaagc ctagagaaac gcaagcagac tggattggga tagaagtatt tgtgtacctg     2820

gattaatgaa ctatgatttt tttttttttt ttttgagacc aaatcttgct ctgtggccca     2880

ggctggagtg cagtggcacg atctcagctc actgcaacct ccacctccca ggttcaagcg     2940

attctcctgc ctcagcctcc tgagcagctg ggattacagg tgcgtgccac cacaccaggc     3000

tggttttctt gtatttttag tagagacggg ggtttcacca tgttagccag gctggtctcg     3060

aactcctgac ctcaggtgat ccacccgcct cagcctccca aagtgctggg attacaggca     3120

tgagccactg tgcccggcct atgattcttt tttttttttt tttttgagac aaagttttgc     3180

tcttgtcacc caggctggag tgcagtggtg caatcttggc tcgcaacctc cgcctcccag     3240

gttcaagaga ttctcctgcc tcagcctccg aagtagctgg gattacaggc gcccgccacc     3300

atgcccggct aattttttgc atttttagta gacatgaggt ttcatcatgt tggccaggcc     3360

ggtctcaaac tcctgacctc aggtgatgca cccacctcag cctcccaaag tgcagggatt     3420

acaggcatga gccaccatgc cgggccatga ttcttaagag aattgactgg gcctcatgaa     3480

taaaaaaatt agaaaatcta aaaaaaa                                         3507


<210>  815
<211>  781
<212>  PRT
<213>  Homo Sapiens

<400>  815

Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu 
1               5                   10                  15      


Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser 
            20                  25                  30          


Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala 
        35                  40                  45              


Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg 
65                  70                  75                  80  


Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Glu Tyr Ser Thr 
                85                  90                  95      


Gln Glu Asn Gly Thr Asp Asp Ser Ala Ala Ser Ser Ser Leu Gly Glu 
            100                 105                 110         


Asn Lys Pro Arg Ser Leu Lys Thr Pro Asp His Pro Glu Gly Asn Glu 
        115                 120                 125             


Gly Asn Gly Pro Arg Pro Tyr Gly Gly Gly Ala Ala Ser Leu Arg Cys 
    130                 135                 140                 


Ser Gln Pro Glu Ala Gly Arg Gly Leu Ser Arg Lys Pro Leu Ser Lys 
145                 150                 155                 160 


Arg Arg Glu Lys Ala Ser Glu Gly Leu Asp Ala Gln Gly Lys Pro Arg 
                165                 170                 175     


Thr Arg Ser Pro Ala Leu Pro Gly Gly Arg Ser Pro Gly Pro Cys Arg 
            180                 185                 190         


Ala Leu Glu Gly Gly Gln Ala Glu Val Arg Leu Arg Arg Asn Ala Ser 
        195                 200                 205             


Ser Ala Gly Arg Leu Gln Gly Leu Ala Gly Gly Ala Pro Gly Gln Lys 
    210                 215                 220                 


Glu Cys Arg Pro Phe Glu Val Tyr Leu Pro Ser Gly Lys Met Arg Pro 
225                 230                 235                 240 


Arg Ser Leu Glu Val Thr Ile Ser Thr Gly Glu Lys Ala Pro Ala Asn 
                245                 250                 255     


Pro Glu Ile Leu Leu Thr Leu Glu Glu Lys Thr Ala Ala Asn Leu Asp 
            260                 265                 270         


Ser Ala Thr Glu Pro Arg Ala Arg Pro Thr Pro Asp Gly Gly Ala Ser 
        275                 280                 285             


Ala Asp Leu Lys Glu Gly Pro Gly Asn Pro Glu His Ser Val Thr Gly 
    290                 295                 300                 


Arg Pro Pro Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly 
305                 310                 315                 320 


Asp Pro Val Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu 
                325                 330                 335     


Ala Val Ser Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys 
            340                 345                 350         


Pro Arg Cys Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser 
        355                 360                 365             


Pro Gln Pro Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu 
    370                 375                 380                 


Leu Phe Cys Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu 
385                 390                 395                 400 


Ser Gln Glu His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala 
                405                 410                 415     


Leu Glu His Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys 
            420                 425                 430         


Leu Arg Lys Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala 
        435                 440                 445             


Val Ser Phe Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg 
    450                 455                 460                 


Lys Leu Glu Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe 
465                 470                 475                 480 


Val Ala Ser Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys 
                485                 490                 495     


Ala Tyr Asp Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu 
            500                 505                 510         


Ile Gly Glu Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu 
        515                 520                 525             


Gln Asp Ile Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro 
    530                 535                 540                 


Glu Lys Trp Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu 
545                 550                 555                 560 


His Gln Lys Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu 
                565                 570                 575     


Thr Leu Arg Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly 
            580                 585                 590         


Ala Gln Ala His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr 
        595                 600                 605             


Pro Asn Leu Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn 
    610                 615                 620                 


Lys Trp Glu Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile 
625                 630                 635                 640 


Ile Val Leu Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu 
                645                 650                 655     


Val Glu Val Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr 
            660                 665                 670         


Ser Ile Ser Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr 
        675                 680                 685             


Trp Val Val Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val 
    690                 695                 700                 


Pro Pro Thr Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile 
705                 710                 715                 720 


Phe Val Asp Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala 
                725                 730                 735     


Arg Ser His Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu 
            740                 745                 750         


Gln Pro Ile Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala 
        755                 760                 765             


Pro Leu Thr Ile Cys Pro Val Gly Gly Gln Gly Pro Asp 
    770                 775                 780     


<210>  816
<211>  2603
<212>  DNA
<213>  Homo Sapiens

<400>  816
agggggcggg gaggcggggg gaggcgggga gcccggccgc cagcgctcgg gtccgcctct       60

gactgcagcg cggcggggcg atgtgtgatt accatggcga ggagtctctg tccgggggcc      120

tggctaagga aaccctatta cctccaggct cgcttctcat atgtgcggat gaaatatctt      180

ttcttttcct ggttagtggt ttttgttgga agctggatta tatatgtgca gtattctacc      240

tatacagaat tatgcagagg aaaggactgt aagaaaataa tatgtgacaa gtacaagact      300

ggagttattg atgggcctgc atgtaacagc ctttgtgtta cagaaactct ttactttgga      360

aaatgtttat ccaccaagcc caacaatcag atgtatttag ggatttggga taatctacca      420

ggtgttgtga aatgtcaaat ggaacaagcg cttcatcttg attttggaac tgaattggaa      480

ccaagaaaag aaatagtgct atttgataag ccaactagag gaactactgt acaaaaattt      540

aaagaaatgg tctatagtct ctttaaggca aaattgggtg accaaggaaa cctctctgaa      600

ctggttaatc tcatcttgac ggtggctgat ggagacaaag atggccaggt ttccttggga      660

gaagcaaagt cggcatgggc acttcttcaa ctgaatgaat ttcttctcat ggtgatactt      720

caagataaag aacatacccc caaattaatg ggattctgtg gtgacctcta tgtgatggaa      780

agtgttgaat atacctctct ttatggaata agccttcctt gggtcattga actttttatt      840

ccatctgggt tcagaagaag catggatcag ctgttcacac catcatggcc aagaaaggcc      900

aaaatagcca taggacttct agaatttgtg gaagatgttt tccatggccc ctacggaaat      960

ttcctcatgt gcgatactag tgccaaaaac ctaggatata atgataagta tgatttgaaa     1020

atggtggata tgagaaaaat tgtgccagag acaaacctga aagaacttat taaggatcgt     1080

cactgtgagt ctgatttgga ctgtgtctat ggcacagatt gtagaactag ctgtgatcag     1140

agtacaatga agtgtacttc agaagtgata caaccaaact tggcaaaagc ttgtcagtta     1200

ctcaaagact acctactgcg tggtgctcca agtgaaattc gtgaagaatt agaaaagcag     1260

ctttattctt gtattgctct caaagtcaca gcaaatcaaa tggaaatgga acattctttg     1320

atactaaata acctaaaaac attattgtgg aagaaaattt cctacactaa tgactcttag     1380

ttcatttgga cataattacc attttaagaa acctgccact tttaaagaac aattttgagc     1440

attaaaaaaa aatggcttca aattccggcc agttacacaa aactccttcc ccccaggcct     1500

gagaagccat cagtatgtga tcactgaagt aatggcaggt gtaggatcaa caggtcccca     1560

agatgtcatt cctgcccttt tagaagccct gttacatctc cgaagtacat tcattgtgta     1620

actattttga ctgactttaa aaaccaatgc tgtgaaaagc ttcattccat aaacatcaac     1680

agtgagtgat ttgtagattt accttagcca aaataccaat gctggaagca ttgtgtttgc     1740

attgaagctg ctgttcaaca agaaaattta taaatttact aatgtcttag catggtaaag     1800

tttgcacatt aacagaaatt aagactgcaa agcaggttaa acttgcttct ttataaaaca     1860

gatgttgggt taatagcatg gtttactgta ttaaagactt atacacccat ttttaacctc     1920

attcagacat caagttatgt gtagcttcac aatggttcaa gtggcttact tcaagaaatc     1980

ttatacttga cagtacacca attttattga ctaaaaatgg atgaactttc ctaaagattc     2040

aaagggccca tcttagtatc acgcagctga ctgagccctt caaaactgac atcttaaggc     2100

ccaatcaaga tccacatatc ctgattttga actatgtgaa agtgggactg taagtgcaag     2160

actaaaataa attatagcag actttttagt aataactttc cattttcaaa cagtatatcc     2220

tgtgggccaa agggctattt cttaaagagg catgtaaatg tatttattta tctaatgttt     2280

ttttccccat gtaaacttga tatacaaggt ttagtatttg ctcctctttc atattatttt     2340

cacacgtata ctcagatttg gcatgtacct ttcaacatct ccataaaatt aaacaccttt     2400

tggagaaaag aaccactatt ttctgctcaa aggtttcgcc tacctaaagt ggaacatgtt     2460

aaaaatctat gtgaccatca ctggacagct ttctctcaaa actttccttc aacgccatgg     2520

attagcacca gttttgttta ctttaaggta cttttcccat tcatcatctg gttataataa     2580

atggatggaa gaaatatttc cca                                             2603


<210>  817
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  817

Met Ala Arg Ser Leu Cys Pro Gly Ala Trp Leu Arg Lys Pro Tyr Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Phe Ser Tyr Val Arg Met Lys Tyr Leu Phe Phe Ser 
            20                  25                  30          


Trp Leu Val Val Phe Val Gly Ser Trp Ile Ile Tyr Val Gln Tyr Ser 
        35                  40                  45              


Thr Tyr Thr Glu Leu Cys Arg Gly Lys Asp Cys Lys Lys Ile Ile Cys 
    50                  55                  60                  


Asp Lys Tyr Lys Thr Gly Val Ile Asp Gly Pro Ala Cys Asn Ser Leu 
65                  70                  75                  80  


Cys Val Thr Glu Thr Leu Tyr Phe Gly Lys Cys Leu Ser Thr Lys Pro 
                85                  90                  95      


Asn Asn Gln Met Tyr Leu Gly Ile Trp Asp Asn Leu Pro Gly Val Val 
            100                 105                 110         


Lys Cys Gln Met Glu Gln Ala Leu His Leu Asp Phe Gly Thr Glu Leu 
        115                 120                 125             


Glu Pro Arg Lys Glu Ile Val Leu Phe Asp Lys Pro Thr Arg Gly Thr 
    130                 135                 140                 


Thr Val Gln Lys Phe Lys Glu Met Val Tyr Ser Leu Phe Lys Ala Lys 
145                 150                 155                 160 


Leu Gly Asp Gln Gly Asn Leu Ser Glu Leu Val Asn Leu Ile Leu Thr 
                165                 170                 175     


Val Ala Asp Gly Asp Lys Asp Gly Gln Val Ser Leu Gly Glu Ala Lys 
            180                 185                 190         


Ser Ala Trp Ala Leu Leu Gln Leu Asn Glu Phe Leu Leu Met Val Ile 
        195                 200                 205             


Leu Gln Asp Lys Glu His Thr Pro Lys Leu Met Gly Phe Cys Gly Asp 
    210                 215                 220                 


Leu Tyr Val Met Glu Ser Val Glu Tyr Thr Ser Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Leu Pro Trp Val Ile Glu Leu Phe Ile Pro Ser Gly Phe Arg Arg Ser 
                245                 250                 255     


Met Asp Gln Leu Phe Thr Pro Ser Trp Pro Arg Lys Ala Lys Ile Ala 
            260                 265                 270         


Ile Gly Leu Leu Glu Phe Val Glu Asp Val Phe His Gly Pro Tyr Gly 
        275                 280                 285             


Asn Phe Leu Met Cys Asp Thr Ser Ala Lys Asn Leu Gly Tyr Asn Asp 
    290                 295                 300                 


Lys Tyr Asp Leu Lys Met Val Asp Met Arg Lys Ile Val Pro Glu Thr 
305                 310                 315                 320 


Asn Leu Lys Glu Leu Ile Lys Asp Arg His Cys Glu Ser Asp Leu Asp 
                325                 330                 335     


Cys Val Tyr Gly Thr Asp Cys Arg Thr Ser Cys Asp Gln Ser Thr Met 
            340                 345                 350         


Lys Cys Thr Ser Glu Val Ile Gln Pro Asn Leu Ala Lys Ala Cys Gln 
        355                 360                 365             


Leu Leu Lys Asp Tyr Leu Leu Arg Gly Ala Pro Ser Glu Ile Arg Glu 
    370                 375                 380                 


Glu Leu Glu Lys Gln Leu Tyr Ser Cys Ile Ala Leu Lys Val Thr Ala 
385                 390                 395                 400 


Asn Gln Met Glu Met Glu His Ser Leu Ile Leu Asn Asn Leu Lys Thr 
                405                 410                 415     


Leu Leu Trp Lys Lys Ile Ser Tyr Thr Asn Asp Ser 
            420                 425             


<210>  818
<211>  4109
<212>  DNA
<213>  Homo Sapiens

<400>  818
cgggccgggg cggcgcgagc ggctggagca acgggccccg cggcagctgc gggcgacgcg       60

gtcgatggac atgggcaccc agggatcggg gcgcaagcgg ctccccaacc gggagcggct      120

cacggcggag gacgacgcgc tcaaccagat cgcgcgggag gcggaagccc ggctcgctgc      180

aaaacgggcg gcccgcgcgg aggctcgcga gatccgcatg aaggagctgg agcggcagca      240

gaaggagatc tatcaggtcc aaaagaaata ttatgggctg gatacaaaat ggggtgacat      300

cgagcagtgg atggaagaca gtgagcgcta ctctcgtaga tccagaagaa acacatcggc      360

ttctgatgaa gacgagcgca tgtcagtggg tagtcgtgga agcctgaggt cgcagcctga      420

cttggagtat gggggtcctt acgcctggac aaatggttat gatggagaat tgtatggatc      480

acagtccctg aatagaagat ctggcaggcc ctcctgtctg tacagcgctg cccggccttc      540

ggggagttac cgggcgtctg tgttggatga aggcagcttc ggtgggaccc gacggggcag      600

cacctccggc tcccgtgctc cctcggagta cagcggccac ctcaactcca gctcccgcgc      660

ctcctccagg gccagctcgg cccgggccag ccctgtggta gaagagagac cagaaaaaga      720

ttttactgag aaggggtctc gtaacatgcc gggcctgtct gcagccacgc tggcctctct      780

gggtgggact tcctctcgga gaggcagcgg agacacctcc atctccatcg acaccgaggc      840

atccatcagg gaaatcaagg aactcaatga gttaaaggac cagattcagg atgtagaagg      900

caaatacatg cagggattga aagagatgaa ggactctcta gcagaagttg aagagaaata      960

taagaaggct atggtttcca atgctcagct agacaatgaa aagacaaact tcatgtacca     1020

ggttgatacc ctaaaagata tgttgctgga gcttgaagaa cagctggctg aatctaggcg     1080

gcagtacgaa gagaaaaaca aagaatttga aagggaaaaa cacgcccaca gtatactgca     1140

atttcagttt gctgaagtca aggaggccct gaagcaaaga gaggaaatgc tcgaggaaat     1200

ccgacagcta cagcagaaac aggcgagttc tatcagggag atttctgatc ttcaggaaac     1260

aatagagtgg aaagacaaaa agataggggc attagagagg cagaaagagt tctttgattc     1320

cgtaaggagt gaacgggatg atcttagaga agaagtagtc atgctgaaag aggaattaaa     1380

gaaacatgga ataatcctaa attcagaaat agctaccaat ggagagactt ccgacaccct     1440

caataatgtt ggataccaag gtcctaccaa gatgacaaaa gaagagttaa atgccctcaa     1500

gtcgacaggg gatgggaccc tagatattag gttgaaaaag ctggttgatg aacgggaatg     1560

cttattggaa cagattaaga aactcaaagg gcagctggag gagagacaga agattggcaa     1620

actagacaat cttcgatctg aagatgatgt cttggaaaac gggacagaca tgcatgtaat     1680

ggacctacaa agggatgcca acagacagat cagcgacctc aaatttaaac ttgcaaaatc     1740

tgagcaagag ataactgcat tagaacaaaa tgtaataagg ttagagagtc aagtatcacg     1800

ttacaaatca gcggctgaaa atgcagaaaa aatagaagat gaacttaagg cagaaaaacg     1860

gaaactccaa agagagctcc gctctgcatt ggataaaaca gaagagctcg aggtgagcaa     1920

cggccactta gtgaagcgtc tggaaaaaat gaaagcaaat cggagtgcac tcttgtccca     1980

gcagtaaatt ccagctctga tcaggcaact ggttggtgac tggagagcat tgtttcatag     2040

gcttttctct gtcctatctg ggagcgctgc ttcttcccct gccttccgag agacgaagac     2100

cgtggcgagc ttggcgctta ggggctcccg tgccatggct caccccaggg agccccagca     2160

gccaccaggt gcctctgtct gcagacccct ggcccgggct ggcgccgacg ctcagaacct     2220

gcaggtactt cataagcaca caggggcctc gagggagctc tgtgtctgac cgcacagcag     2280

cctctgaatg ccgctggaag tgatgatcaa agtaaagatt cagttgggac ttgagttttt     2340

tttttttttc atgtgtcttg ctgaagatta aggggaaatg ttacagtgtt gggacttcct     2400

ttcatggcag aatctacaat ttgagcgact tcagtagtat ctcttagtct acgcttttca     2460

tacacaaaac actgtggaac cacaagccat taccaagcaa aactctttca ctggaaacaa     2520

gggggcagtc tagaagtaaa agtgacctta agaagactct ttacaggcaa caaatgaagc     2580

ttttctaagg gatttttgca tcagttcagt cataagaata cttttttcca gggtaattag     2640

gcaatagctt cactgaaaat gacagctttt cattgcatta tttaatcctt atatttggaa     2700

ttgaagtcgt taacttcttt taaagaatgt actattagaa aaattaaaaa tgaaatgttg     2760

agagacttca gcaatgtggt tctaattttt ttccactgag aaagaagatc tttaatttca     2820

tattaatggt tctgtatatt ttgggtcatc tttttatttt ttaagaatat caagtcaatt     2880

catttttctt tccctattta aaaaaaaagg tgttttcaca gaatgagtgc acttaaaaag     2940

tgaagtgaag gaggaggtaa cagtagagac gatggcaata tcatcaagga caaaagtaaa     3000

aacgtttagc tacctgctga tttttagtga ctgttcatat atgttgtatt tcaagtatgg     3060

ctggtgaagc cagtcagctt ttcgggacgt tagcaagtgg aaactgagtc agtatcatcc     3120

aaaaccatat ctagtcttaa cacatggaga atgctggagt gagggttgtg agttcagggt     3180

atataatcaa gaaaacactc ccagcataat gctaggggtc accagtgtcc atcccccaga     3240

actgtatgga tctaggatat acacagctgc gttgcattaa gaaagagatg aaatctctat     3300

taaaatacac aagatttttg tatctccttg tgcagaggat atttgccact gcccattggg     3360

aagcagacaa gttatagggg gctgggggcc aacactggca agtaggaaac cacgggtcgg     3420

acaggtgagc aaaatgtgct ggcaggtggg caccactggg agacccacac tgcacacccg     3480

ggcaccgtat gaacaggaaa gaggaaggaa gctggacgaa gcccctcagg gaccctgtgc     3540

tgaccatgct gggcccaccg gcaaaaggga gatattcagt tccttgtctc atccttaagg     3600

tttcttccac aacatctgaa tacaagcatg tttaactggg aaaatgtcta tgtcatgcgt     3660

gaataacacc agcagcaaac actcacacat cacgcagaca cggccggcag catgctgacg     3720

cttttaggta tttttcactc atgcaatttt cacatatttt cactcatttc atttgcacgg     3780

aaattctatg aggtagatgc tgttatcaaa tccacattac agatgaggga cccagggtcc     3840

aggaaggtga actggcagaa gtctcccagc tggtagaaca gggctgcaag gcatcgattc     3900

ccaggtgtct cacagccctg agaagatggc gttttcccta tcagtggctc tgaggaagtc     3960

aagccttcag tctctacctc tcccaccaat tcttttggaa acagcaaacc aatgttacac     4020

acacttccta atccagagga agctagaaca cgatttttaa atttatttag taaaataaaa     4080

ctttttttgc agatgtaacg aaaaaaaaa                                       4109


<210>  819
<211>  640
<212>  PRT
<213>  Homo Sapiens

<400>  819

Met Asp Met Gly Thr Gln Gly Ser Gly Arg Lys Arg Leu Pro Asn Arg 
1               5                   10                  15      


Glu Arg Leu Thr Ala Glu Asp Asp Ala Leu Asn Gln Ile Ala Arg Glu 
            20                  25                  30          


Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala Ala Arg Ala Glu Ala Arg 
        35                  40                  45              


Glu Ile Arg Met Lys Glu Leu Glu Arg Gln Gln Lys Glu Ile Tyr Gln 
    50                  55                  60                  


Val Gln Lys Lys Tyr Tyr Gly Leu Asp Thr Lys Trp Gly Asp Ile Glu 
65                  70                  75                  80  


Gln Trp Met Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
                85                  90                  95      


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
            100                 105                 110         


Ser Leu Arg Ser Gln Pro Asp Leu Glu Tyr Gly Gly Pro Tyr Ala Trp 
        115                 120                 125             


Thr Asn Gly Tyr Asp Gly Glu Leu Tyr Gly Ser Gln Ser Leu Asn Arg 
    130                 135                 140                 


Arg Ser Gly Arg Pro Ser Cys Leu Tyr Ser Ala Ala Arg Pro Ser Gly 
145                 150                 155                 160 


Ser Tyr Arg Ala Ser Val Leu Asp Glu Gly Ser Phe Gly Gly Thr Arg 
                165                 170                 175     


Arg Gly Ser Thr Ser Gly Ser Arg Ala Pro Ser Glu Tyr Ser Gly His 
            180                 185                 190         


Leu Asn Ser Ser Ser Arg Ala Ser Ser Arg Ala Ser Ser Ala Arg Ala 
        195                 200                 205             


Ser Pro Val Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
    210                 215                 220                 


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
225                 230                 235                 240 


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
                245                 250                 255     


Thr Glu Ala Ser Ile Arg Glu Ile Lys Glu Leu Asn Glu Leu Lys Asp 
            260                 265                 270         


Gln Ile Gln Asp Val Glu Gly Lys Tyr Met Gln Gly Leu Lys Glu Met 
        275                 280                 285             


Lys Asp Ser Leu Ala Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
    290                 295                 300                 


Ser Asn Ala Gln Leu Asp Asn Glu Lys Thr Asn Phe Met Tyr Gln Val 
305                 310                 315                 320 


Asp Thr Leu Lys Asp Met Leu Leu Glu Leu Glu Glu Gln Leu Ala Glu 
                325                 330                 335     


Ser Arg Arg Gln Tyr Glu Glu Lys Asn Lys Glu Phe Glu Arg Glu Lys 
            340                 345                 350         


His Ala His Ser Ile Leu Gln Phe Gln Phe Ala Glu Val Lys Glu Ala 
        355                 360                 365             


Leu Lys Gln Arg Glu Glu Met Leu Glu Glu Ile Arg Gln Leu Gln Gln 
    370                 375                 380                 


Lys Gln Ala Ser Ser Ile Arg Glu Ile Ser Asp Leu Gln Glu Thr Ile 
385                 390                 395                 400 


Glu Trp Lys Asp Lys Lys Ile Gly Ala Leu Glu Arg Gln Lys Glu Phe 
                405                 410                 415     


Phe Asp Ser Val Arg Ser Glu Arg Asp Asp Leu Arg Glu Glu Val Val 
            420                 425                 430         


Met Leu Lys Glu Glu Leu Lys Lys His Gly Ile Ile Leu Asn Ser Glu 
        435                 440                 445             


Ile Ala Thr Asn Gly Glu Thr Ser Asp Thr Leu Asn Asn Val Gly Tyr 
    450                 455                 460                 


Gln Gly Pro Thr Lys Met Thr Lys Glu Glu Leu Asn Ala Leu Lys Ser 
465                 470                 475                 480 


Thr Gly Asp Gly Thr Leu Asp Ile Arg Leu Lys Lys Leu Val Asp Glu 
                485                 490                 495     


Arg Glu Cys Leu Leu Glu Gln Ile Lys Lys Leu Lys Gly Gln Leu Glu 
            500                 505                 510         


Glu Arg Gln Lys Ile Gly Lys Leu Asp Asn Leu Arg Ser Glu Asp Asp 
        515                 520                 525             


Val Leu Glu Asn Gly Thr Asp Met His Val Met Asp Leu Gln Arg Asp 
    530                 535                 540                 


Ala Asn Arg Gln Ile Ser Asp Leu Lys Phe Lys Leu Ala Lys Ser Glu 
545                 550                 555                 560 


Gln Glu Ile Thr Ala Leu Glu Gln Asn Val Ile Arg Leu Glu Ser Gln 
                565                 570                 575     


Val Ser Arg Tyr Lys Ser Ala Ala Glu Asn Ala Glu Lys Ile Glu Asp 
            580                 585                 590         


Glu Leu Lys Ala Glu Lys Arg Lys Leu Gln Arg Glu Leu Arg Ser Ala 
        595                 600                 605             


Leu Asp Lys Thr Glu Glu Leu Glu Val Ser Asn Gly His Leu Val Lys 
    610                 615                 620                 


Arg Leu Glu Lys Met Lys Ala Asn Arg Ser Ala Leu Leu Ser Gln Gln 
625                 630                 635                 640 


<210>  820
<211>  5235
<212>  DNA
<213>  Homo Sapiens

<400>  820
gcggggagct cgcaccgccg cgcccgggcc gcgagtgatg ataacctaag aggccggcgc       60

gggcgggcgt gagcggcgga ggagccgggc gcggcgacac gcggccatgg agcgggagcc      120

ggcggggacc gaggagcccg ggcctccggg acggcggagg cgccgagagg gcaggacgcg      180

cacggtgcgc tccaacctgc tgccgccccc gggcgccgag gaccctgcgg ctggcgcggc      240

caagggcgag cggcgacggc ggcgcgggtg tgcccagcac ctggccgaca accggctcaa      300

gactaccaag tacacgctgc tgtccttcct gcccaagaac ctgttcgagc agttccaccg      360

cccggccaac gtgtactttg tcttcatcgc gctgctcaac ttcgtgccgg cggtgaacgc      420

cttccagccc ggcctggcac tggcgccggt gctcttcatc ctggccatca cggccttcag      480

ggacctgtgg gaggactaca gccgccaccg ctccgaccac aagatcaacc acctgggctg      540

cctggtcttc agcagggaag aaaagaaata cgtgaaccga ttctggaaag aaatccacgt      600

gggagacttt gtgcgtcttc gctgcaacga aatcttccct gcggacattc tgctgctctc      660

ctccagtgac cccgacgggc tatgccacat cgagaccgcc aacctggatg gagagaccaa      720

cctgaagcgg cggcaggtgg tccgcggctt ctcggagctt gtctccgaat tcaatccttt      780

gacgttcacc agcgtgatcg aatgcgagaa gccaaacaac gacctgagta ggtttcgcgg      840

ctgcatcata catgacaacg ggaaaaaggc cgggctgtat aaagaaaacc tgctgctgag      900

gggctgcacc cttaggaaca cggacgcagt cgtcggcatt gtcatctacg caggacatga      960

aaccaaggct ctgctgaaca acagtgggcc ccgctacaag cgcagcaagc tggagaggca     1020

gatgaactgc gacgtgctct ggtgtgtcct gctccttgtt tgcatgtctc tgttttcagc     1080

agtcggacat ggactgtgga tatggcggta tcaagagaag aagtcattat tttatgtccc     1140

caagtctgat ggaagctcct tatccccagt cacagctgca gtttactcat ttttaacaat     1200

gataatagtt ctgcaggttt tgatcccaat ttccttatac gtttccattg aaattgttaa     1260

agcatgccaa gtgtacttca ttaaccagga catgcagttg tatgacgaag aaacagactc     1320

gcagctgcag tgccgagctc tgaacatcac ggaagactta ggacagatac agtacatttt     1380

ctcagataaa actggcactt tgacagagaa taagatggtt ttccgaagat gcactgtgtc     1440

tggtgtagaa tattctcatg atgcaaatgc gcagcgtctg gccaggtacc aagaggcaga     1500

ctcggaggag gaggaggtgg tgcccagagg gggctcggtg tcccagcgcg gcagcatcgg     1560

cagccaccag agtgtccggg tggtgcacag aacccagagc accaagtccc accggcgcac     1620

gggcagccgg gccgaggcca agagggccag catgctgtcc aagcacacgg ccttcagcag     1680

ccccatggag aaggatatca cgcccgaccc aaagctgctg gagaaggtga gtgagtgtga     1740

caagagccta gccgtggcga ggcatcagga gcacctgctg gcccacctct cgcctgagct     1800

gtctgacgtc tttgatttct tcatcgcact caccatctgc aacacagtcg tcgtcacgtc     1860

cccggatcag ccacgaacaa aggtgagggt gaggtttgag ctgaagtccc cggtgaagac     1920

gatagaagac ttcctgcgga ggttcacacc cagctgcctg acctcaggct gcagcagcat     1980

cgggagcctg gccgccaaca agtccagcca caagttgggc tccagcttcc cgtccacccc     2040

gtccagcgac ggcatgcttc tcaggctgga ggagaggctg ggccagccca cctcggccat     2100

cgccagcaac ggctacagca gccaggcgga caactgggcc tcggagcttg ctcaggagca     2160

ggagtcagag cgcgagctgc ggtacgaggc ggagagcccg gatgaggccg cactggtgta     2220

tgcggccaga gcctacaact gcgtgcttgt ggagcggctg cacgaccaag tgtcagtgga     2280

gctgccccac ctgggcaggc tcaccttcga gctcctgcac acactgggtt tcgattccgt     2340

ccgcaagagg atgtcagtgg tgatccggca cccgcttacc gatgagatca acgtctacac     2400

caagggggcc gactcagtgg tcatggatct cctgcagccc tgctcttcag ttgacgccag     2460

agggaggcat caaaaaaaga ttcggagcaa aactcagaat tacctcaacg tgtatgcggc     2520

ggaaggcctg cgcaccttgt gcatcgccaa gagagttctg agtaaagaag agtatgcctg     2580

ctggttgcaa agccacctag aagccgaatc ctccctggaa aacagcgagg agctcctctt     2640

ccagtctgcc attcgcctgg agaccaacct gcacttgtta ggtgccactg ggattgaaga     2700

ccgcctgcag gacggagtcc ctgaaactat ttctaaattg cgtcaagcgg gcctgcagat     2760

ttgggttctc actggtgaca aacaagaaac agctgtcaac attgcatatg cctgcaaact     2820

gctggaccac gacgaggagg tcatcaccct gaatgccacc tcccaggagg cgtgtgcagc     2880

cctgctagac cagtgcctat gctacgtgca gtccagaggc ctccagagag cccctgagaa     2940

gaccaagggc aaagtgagca tgaggttctc ctctctctgc ccaccctcca cgtccactgc     3000

ctctggccgc agacccagcc tcgtgatcga tgggagaagc ctggcctacg ctctcgagaa     3060

aaacctggag gacaaattcc tcttccttgc caagcagtgc cgctccgtcc tctgctgtcg     3120

gtcgacgcct ctgcagaaga gcatggtggt gaagctggtg cggagcaagc tcaaggccat     3180

gaccctggcc ataggtgatg gagccaatga tgtcagcatg atccaggtgg cagatgtggg     3240

tgtgggaatc tccggccagg agggtatgca ggcagtgatg gccagcgact ttgcagtgcc     3300

gaaattccga tacctggaga ggctcttgat tcttcacggg cattggtgct actcccgact     3360

tgccaacatg gtgctgtact tcttctacaa aaacacaatg ttcgtgggcc tcctgttttg     3420

gttccagttt ttctgtggct tctctgcatc taccatgatt gaccagtggt atctaatctt     3480

ctttaatctg ctcttctcgt cacttccccc gctcgtgact ggggtgctgg acagggatgt     3540

gccagccaat gtgctgctga ccaacccgca gctctacaag agtggccaga acatggagga     3600

ataccggcca cgaacgttct ggtttaacat ggccgacgcc gccttccaga gcctggtttg     3660

cttttccatt ccttacctgg cctactatga ctcgaacgtg gacctgttta cctgggggac     3720

ccctattgtg acaatcgcgc tgctcacttt cctgctccac ctgggcattg aaaccaaaac     3780

ctggacctgg ctcaactgga taacgtgtgg cttcagtgtc cttttgtttt tcaccgtggc     3840

tttgatttac aatgcgtctt gtgccacgtg ctatcctccg tccaaccctt actggactat     3900

gcaagcctta ctgggtgacc cagtgtttta cttgacttgc ctgatgacgc ctgtcgctgc     3960

actgctgccc agattgtttt tcagatccct ccaggggagg gttttcccca cacaacttca     4020

gctggcacgt cagttgacca ggaagtcccc caggagatgc agtgctccca aagagacctt     4080

tgctcaggga cgcctcccga aggactcggg aaccgagcac tcatcaggga ggacagtcaa     4140

gacctctgtg cccctgtccc agccttcttg gcacacacag cagccggtct gctccctgga     4200

ggccagcggg gagcccagca cagtggacat gagcatgcca gtgagggagc acaccctgct     4260

ggaggggctg agcgcaccgg cccccatgtc ctctgcgcca ggggaggctg tcctgaggag     4320

tccaggaggg tgtcctgagg agtccaaggt gagagctgcc agcaccggca gggtgacccc     4380

cctgtcttcc ctcttcagcc tgcctacctt cagcttactc aactggattt cctcctggtc     4440

gctggtcagc aggctgggga gtgtcttaca gttctcccgg acggagcagc ttgcagatgg     4500

acaagcggga cgtggacttc ctgtccagcc ccactcaggc cgatcaggac ttcaagggcc     4560

agaccacaga ctacttatag gagcatcttc aaggcggtca cagtgaaaac cttgaaatgg     4620

ccttttttaa tatatataaa taaatgttaa tattatttat gtttattatt tgcacagaag     4680

agttctaggg agatgtattt ctaaatgttt cccaggctaa tacaggaaac aagaggtacc     4740

aaaaaagaaa gtttattttt taaaattcta agtagagtat attgaaaaga aaaagaagag     4800

ccttaacata tataaaagtt taaagaagag taacacttga aaagtgtgtt tagatttatt     4860

ttttcatctc atttttaaga acaagcagta cgatttgttt tcttcaacat gtgtgactgc     4920

gcactgagta caaatgtgtg actgctcatg gttaatgcag gcaggtgtga acatggggga     4980

acaatgagca gagatggcag agggcagagc acatggcccc cagaggcttc cagtctcact     5040

gacacaggag ggctgggctc cacttcatcc agatgaagga aaggaagacc tcaagaaaaa     5100

ttcacagttg agtgcatccc agcattctgt tccgggcagg catttcagga agaccgcctt     5160

gtaggtatta catccctggt gtcgtatttt gcctgttaaa tcgtaacaag caataaacaa     5220

ctttcacttt gcaaa                                                      5235


<210>  821
<211>  1499
<212>  PRT
<213>  Homo Sapiens

<400>  821

Met Glu Arg Glu Pro Ala Gly Thr Glu Glu Pro Gly Pro Pro Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Glu Gly Arg Thr Arg Thr Val Arg Ser Asn Leu Leu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Asp Pro Ala Ala Gly Ala Ala Lys Gly Glu 
        35                  40                  45              


Arg Arg Arg Arg Arg Gly Cys Ala Gln His Leu Ala Asp Asn Arg Leu 
    50                  55                  60                  


Lys Thr Thr Lys Tyr Thr Leu Leu Ser Phe Leu Pro Lys Asn Leu Phe 
65                  70                  75                  80  


Glu Gln Phe His Arg Pro Ala Asn Val Tyr Phe Val Phe Ile Ala Leu 
                85                  90                  95      


Leu Asn Phe Val Pro Ala Val Asn Ala Phe Gln Pro Gly Leu Ala Leu 
            100                 105                 110         


Ala Pro Val Leu Phe Ile Leu Ala Ile Thr Ala Phe Arg Asp Leu Trp 
        115                 120                 125             


Glu Asp Tyr Ser Arg His Arg Ser Asp His Lys Ile Asn His Leu Gly 
    130                 135                 140                 


Cys Leu Val Phe Ser Arg Glu Glu Lys Lys Tyr Val Asn Arg Phe Trp 
145                 150                 155                 160 


Lys Glu Ile His Val Gly Asp Phe Val Arg Leu Arg Cys Asn Glu Ile 
                165                 170                 175     


Phe Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Asp Pro Asp Gly Leu 
            180                 185                 190         


Cys His Ile Glu Thr Ala Asn Leu Asp Gly Glu Thr Asn Leu Lys Arg 
        195                 200                 205             


Arg Gln Val Val Arg Gly Phe Ser Glu Leu Val Ser Glu Phe Asn Pro 
    210                 215                 220                 


Leu Thr Phe Thr Ser Val Ile Glu Cys Glu Lys Pro Asn Asn Asp Leu 
225                 230                 235                 240 


Ser Arg Phe Arg Gly Cys Ile Ile His Asp Asn Gly Lys Lys Ala Gly 
                245                 250                 255     


Leu Tyr Lys Glu Asn Leu Leu Leu Arg Gly Cys Thr Leu Arg Asn Thr 
            260                 265                 270         


Asp Ala Val Val Gly Ile Val Ile Tyr Ala Gly His Glu Thr Lys Ala 
        275                 280                 285             


Leu Leu Asn Asn Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg 
    290                 295                 300                 


Gln Met Asn Cys Asp Val Leu Trp Cys Val Leu Leu Leu Val Cys Met 
305                 310                 315                 320 


Ser Leu Phe Ser Ala Val Gly His Gly Leu Trp Ile Trp Arg Tyr Gln 
                325                 330                 335     


Glu Lys Lys Ser Leu Phe Tyr Val Pro Lys Ser Asp Gly Ser Ser Leu 
            340                 345                 350         


Ser Pro Val Thr Ala Ala Val Tyr Ser Phe Leu Thr Met Ile Ile Val 
        355                 360                 365             


Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val 
    370                 375                 380                 


Lys Ala Cys Gln Val Tyr Phe Ile Asn Gln Asp Met Gln Leu Tyr Asp 
385                 390                 395                 400 


Glu Glu Thr Asp Ser Gln Leu Gln Cys Arg Ala Leu Asn Ile Thr Glu 
                405                 410                 415     


Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu 
            420                 425                 430         


Thr Glu Asn Lys Met Val Phe Arg Arg Cys Thr Val Ser Gly Val Glu 
        435                 440                 445             


Tyr Ser His Asp Ala Asn Ala Gln Arg Leu Ala Arg Tyr Gln Glu Ala 
    450                 455                 460                 


Asp Ser Glu Glu Glu Glu Val Val Pro Arg Gly Gly Ser Val Ser Gln 
465                 470                 475                 480 


Arg Gly Ser Ile Gly Ser His Gln Ser Val Arg Val Val His Arg Thr 
                485                 490                 495     


Gln Ser Thr Lys Ser His Arg Arg Thr Gly Ser Arg Ala Glu Ala Lys 
            500                 505                 510         


Arg Ala Ser Met Leu Ser Lys His Thr Ala Phe Ser Ser Pro Met Glu 
        515                 520                 525             


Lys Asp Ile Thr Pro Asp Pro Lys Leu Leu Glu Lys Val Ser Glu Cys 
    530                 535                 540                 


Asp Lys Ser Leu Ala Val Ala Arg His Gln Glu His Leu Leu Ala His 
545                 550                 555                 560 


Leu Ser Pro Glu Leu Ser Asp Val Phe Asp Phe Phe Ile Ala Leu Thr 
                565                 570                 575     


Ile Cys Asn Thr Val Val Val Thr Ser Pro Asp Gln Pro Arg Thr Lys 
            580                 585                 590         


Val Arg Val Arg Phe Glu Leu Lys Ser Pro Val Lys Thr Ile Glu Asp 
        595                 600                 605             


Phe Leu Arg Arg Phe Thr Pro Ser Cys Leu Thr Ser Gly Cys Ser Ser 
    610                 615                 620                 


Ile Gly Ser Leu Ala Ala Asn Lys Ser Ser His Lys Leu Gly Ser Ser 
625                 630                 635                 640 


Phe Pro Ser Thr Pro Ser Ser Asp Gly Met Leu Leu Arg Leu Glu Glu 
                645                 650                 655     


Arg Leu Gly Gln Pro Thr Ser Ala Ile Ala Ser Asn Gly Tyr Ser Ser 
            660                 665                 670         


Gln Ala Asp Asn Trp Ala Ser Glu Leu Ala Gln Glu Gln Glu Ser Glu 
        675                 680                 685             


Arg Glu Leu Arg Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val 
    690                 695                 700                 


Tyr Ala Ala Arg Ala Tyr Asn Cys Val Leu Val Glu Arg Leu His Asp 
705                 710                 715                 720 


Gln Val Ser Val Glu Leu Pro His Leu Gly Arg Leu Thr Phe Glu Leu 
                725                 730                 735     


Leu His Thr Leu Gly Phe Asp Ser Val Arg Lys Arg Met Ser Val Val 
            740                 745                 750         


Ile Arg His Pro Leu Thr Asp Glu Ile Asn Val Tyr Thr Lys Gly Ala 
        755                 760                 765             


Asp Ser Val Val Met Asp Leu Leu Gln Pro Cys Ser Ser Val Asp Ala 
    770                 775                 780                 


Arg Gly Arg His Gln Lys Lys Ile Arg Ser Lys Thr Gln Asn Tyr Leu 
785                 790                 795                 800 


Asn Val Tyr Ala Ala Glu Gly Leu Arg Thr Leu Cys Ile Ala Lys Arg 
                805                 810                 815     


Val Leu Ser Lys Glu Glu Tyr Ala Cys Trp Leu Gln Ser His Leu Glu 
            820                 825                 830         


Ala Glu Ser Ser Leu Glu Asn Ser Glu Glu Leu Leu Phe Gln Ser Ala 
        835                 840                 845             


Ile Arg Leu Glu Thr Asn Leu His Leu Leu Gly Ala Thr Gly Ile Glu 
    850                 855                 860                 


Asp Arg Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys Leu Arg Gln 
865                 870                 875                 880 


Ala Gly Leu Gln Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala 
                885                 890                 895     


Val Asn Ile Ala Tyr Ala Cys Lys Leu Leu Asp His Asp Glu Glu Val 
            900                 905                 910         


Ile Thr Leu Asn Ala Thr Ser Gln Glu Ala Cys Ala Ala Leu Leu Asp 
        915                 920                 925             


Gln Cys Leu Cys Tyr Val Gln Ser Arg Gly Leu Gln Arg Ala Pro Glu 
    930                 935                 940                 


Lys Thr Lys Gly Lys Val Ser Met Arg Phe Ser Ser Leu Cys Pro Pro 
945                 950                 955                 960 


Ser Thr Ser Thr Ala Ser Gly Arg Arg Pro Ser Leu Val Ile Asp Gly 
                965                 970                 975     


Arg Ser Leu Ala Tyr Ala Leu Glu Lys Asn Leu Glu Asp Lys Phe Leu 
            980                 985                 990         


Phe Leu Ala Lys Gln Cys Arg Ser  Val Leu Cys Cys Arg  Ser Thr Pro 
        995                 1000                 1005             


Leu Gln  Lys Ser Met Val Val  Lys Leu Val Arg Ser  Lys Leu Lys 
    1010                 1015                 1020             


Ala Met  Thr Leu Ala Ile Gly  Asp Gly Ala Asn Asp  Val Ser Met 
    1025                 1030                 1035             


Ile Gln  Val Ala Asp Val Gly  Val Gly Ile Ser Gly  Gln Glu Gly 
    1040                 1045                 1050             


Met Gln  Ala Val Met Ala Ser  Asp Phe Ala Val Pro  Lys Phe Arg 
    1055                 1060                 1065             


Tyr Leu  Glu Arg Leu Leu Ile  Leu His Gly His Trp  Cys Tyr Ser 
    1070                 1075                 1080             


Arg Leu  Ala Asn Met Val Leu  Tyr Phe Phe Tyr Lys  Asn Thr Met 
    1085                 1090                 1095             


Phe Val  Gly Leu Leu Phe Trp  Phe Gln Phe Phe Cys  Gly Phe Ser 
    1100                 1105                 1110             


Ala Ser  Thr Met Ile Asp Gln  Trp Tyr Leu Ile Phe  Phe Asn Leu 
    1115                 1120                 1125             


Leu Phe  Ser Ser Leu Pro Pro  Leu Val Thr Gly Val  Leu Asp Arg 
    1130                 1135                 1140             


Asp Val  Pro Ala Asn Val Leu  Leu Thr Asn Pro Gln  Leu Tyr Lys 
    1145                 1150                 1155             


Ser Gly  Gln Asn Met Glu Glu  Tyr Arg Pro Arg Thr  Phe Trp Phe 
    1160                 1165                 1170             


Asn Met  Ala Asp Ala Ala Phe  Gln Ser Leu Val Cys  Phe Ser Ile 
    1175                 1180                 1185             


Pro Tyr  Leu Ala Tyr Tyr Asp  Ser Asn Val Asp Leu  Phe Thr Trp 
    1190                 1195                 1200             


Gly Thr  Pro Ile Val Thr Ile  Ala Leu Leu Thr Phe  Leu Leu His 
    1205                 1210                 1215             


Leu Gly  Ile Glu Thr Lys Thr  Trp Thr Trp Leu Asn  Trp Ile Thr 
    1220                 1225                 1230             


Cys Gly  Phe Ser Val Leu Leu  Phe Phe Thr Val Ala  Leu Ile Tyr 
    1235                 1240                 1245             


Asn Ala  Ser Cys Ala Thr Cys  Tyr Pro Pro Ser Asn  Pro Tyr Trp 
    1250                 1255                 1260             


Thr Met  Gln Ala Leu Leu Gly  Asp Pro Val Phe Tyr  Leu Thr Cys 
    1265                 1270                 1275             


Leu Met  Thr Pro Val Ala Ala  Leu Leu Pro Arg Leu  Phe Phe Arg 
    1280                 1285                 1290             


Ser Leu  Gln Gly Arg Val Phe  Pro Thr Gln Leu Gln  Leu Ala Arg 
    1295                 1300                 1305             


Gln Leu  Thr Arg Lys Ser Pro  Arg Arg Cys Ser Ala  Pro Lys Glu 
    1310                 1315                 1320             


Thr Phe  Ala Gln Gly Arg Leu  Pro Lys Asp Ser Gly  Thr Glu His 
    1325                 1330                 1335             


Ser Ser  Gly Arg Thr Val Lys  Thr Ser Val Pro Leu  Ser Gln Pro 
    1340                 1345                 1350             


Ser Trp  His Thr Gln Gln Pro  Val Cys Ser Leu Glu  Ala Ser Gly 
    1355                 1360                 1365             


Glu Pro  Ser Thr Val Asp Met  Ser Met Pro Val Arg  Glu His Thr 
    1370                 1375                 1380             


Leu Leu  Glu Gly Leu Ser Ala  Pro Ala Pro Met Ser  Ser Ala Pro 
    1385                 1390                 1395             


Gly Glu  Ala Val Leu Arg Ser  Pro Gly Gly Cys Pro  Glu Glu Ser 
    1400                 1405                 1410             


Lys Val  Arg Ala Ala Ser Thr  Gly Arg Val Thr Pro  Leu Ser Ser 
    1415                 1420                 1425             


Leu Phe  Ser Leu Pro Thr Phe  Ser Leu Leu Asn Trp  Ile Ser Ser 
    1430                 1435                 1440             


Trp Ser  Leu Val Ser Arg Leu  Gly Ser Val Leu Gln  Phe Ser Arg 
    1445                 1450                 1455             


Thr Glu  Gln Leu Ala Asp Gly  Gln Ala Gly Arg Gly  Leu Pro Val 
    1460                 1465                 1470             


Gln Pro  His Ser Gly Arg Ser  Gly Leu Gln Gly Pro  Asp His Arg 
    1475                 1480                 1485             


Leu Leu  Ile Gly Ala Ser Ser  Arg Arg Ser Gln 
    1490                 1495                 


<210>  822
<211>  2722
<212>  DNA
<213>  Homo Sapiens

<400>  822
gagtctggcc gcagtcgcgg cagtggtggc ttcccatccc caaaaggcgc cctccgactc       60

cttgcgccgc actgctcgcc gggccagtcc ggaaacgggt cgtggagctc cgcaccactc      120

ccgctggttc ccgaaggcag atcccttctc ccgagagttg cgagaaactt tcccttgtcc      180

ccgacgctgc agcggctcgg gtaccgtggc agccgcaggt ttctgaaccc cgggccacgc      240

tccccgcgcc tcggcttcgc gctcgtgtag atcgttccct ctctggttgc acgctgggga      300

tcccggacct cgattctgcg ggcgagatgc ccctgggaca catcatgagg ctggacctgg      360

agaaaattgc cctggagtac atcgtgccct gtctgcacga ggtgggcttc tgctacctgg      420

acaacttcct gggcgaggtg gtgggcgact gcgtcctgga gcgcgtcaag cagctgcact      480

gcaccggggc cctgcgggac ggccagctgg cggggccgcg cgccggcgtc tccaagcgac      540

acctgcgggg cgaccagatc acgtggatcg ggggcaacga ggagggctgc gaggccatca      600

gcttcctcct gtccctcatc gacaggctgg tcctctactg cgggagccgg ctgggcaaat      660

actacgtcaa ggagaggtct aaggcaatgg tggcttgcta tccgggaaat ggaacaggtt      720

atgttcgcca cgtggacaac cccaacggtg atggtcgctg catcacctgc atctactatc      780

tgaacaagaa ttgggatgcc aagctacatg gtgggatcct gcggatattt ccagagggga      840

aatcattcat agcagatgtg gagcccattt ttgacagact cctgttcttc tggtcagatc      900

gtaggaaccc acacgaagtg cagccctctt acgcaaccag atatgctatg actgtctggt      960

actttgatgc tgaagaaagg gcagaagcca aaaagaaatt caggaattta actaggaaaa     1020

ctgaatctgc cctcactgaa gactgaccgt gctctgaaat ctgctggcct tgttcatttt     1080

agtaacggtt cctgaattct cttaaattct ttgagatcca aagatggcct cttcagtgac     1140

aacaatctcc ctgctacttc ttgcatcctt cacatccctg tcttgtgtgt ggtacttcat     1200

gttttcttgc caagactgtg ttgatcttca gatactctct ttgccagatg aagttacttg     1260

ctaactccag aaattcctgc agacatccta ctcggccagc ggtttacctg atagattcgg     1320

taatactatc aagagaagag cctaggagca cagcgaggga atgaacctta cttgcacttt     1380

atgtatactt cctgatttga aaggaggagg tttgaaaaga aaaaaatgga ggtggtagat     1440

gccacagaga ggcatcacgg aagccttaac agcaggaaac agagaaattt gtgtcatctg     1500

aacaatttcc agatgttctt aatccagggc tgttggggtt tctggagaat tatcacaacc     1560

taatgacatt aatacctcta gaaagggctg ctgtcatagt gaacaattta taagtgtccc     1620

atggggcaga cactcctttt ttcccagtcc tgcaacctgg attttctgcc tcagccccat     1680

tttgctgaaa ataatgactt tctgaataaa gatggcaaca caattttttc tccattttca     1740

gttcttacct gggaacctaa ttccccagaa gctaaaaaac tagacattag ttgttttggt     1800

tgctttgttg gaatggaatt taaatttaaa tgaaaggaaa aatatatccc tggtagtttt     1860

gtgttaacca ctgataactg tggaaagagc taggtctact gatatacaat aaacatgtgt     1920

gcatcttgaa caatttgaga ggggaggtgg agttggaaat gtgggtgttc ctgttttttt     1980

tttttttttt tttttagttt tcctttttaa tgagctcacc ctttaacaca aaaaaagcaa     2040

ggtgatgtat tttaaaaaag gaagtggaaa taaaaaaatc tcaaagctat ttgagttctc     2100

gtctgtccct agcagtcttt cttcagctca cttggctctc tagatccact gtggttggca     2160

gtatgaccag aatcatggaa tttgctagaa ctgtggaagc ttctactcct gcagtaagca     2220

cagatcgcac tgcctcaata acttggtatt gagcacgtat tttgcaaaag ctacttttcc     2280

tagttttcag tattactttc atgttttaaa aatcccttta atttcttgct tgaaaatccc     2340

atgaacatta aagagccaga aatattttcc tttgttatgt acggatatat atatatatag     2400

tcttccaaga tagaagttta ctttttcctc ttctggtttt ggaaaatttc cagataagac     2460

atgtcaccat taattctcaa cgactgctct attttgttgt acggtaatag ttatcacctt     2520

ctaaattact atgtaattta ttcacttatt atgtttattg tcttgtatcc tttctctgga     2580

gtgtaagcac aatgaagaca ggaattttgt atatttttaa ccaatgcaac atactctcag     2640

cacctaaaat agtgccggga acatagtaag ggctcagtaa atacttgttg aataaactca     2700

gtctcctaca ttagcattct aa                                              2722


<210>  823
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  823

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


<210>  824
<211>  3045
<212>  DNA
<213>  Homo Sapiens

<400>  824
ctttcttcac tctgaagcca agagccgacc ttctgagccc tcaagaaaga tcagaacaga       60

ttcatgggtg atttagccta tctgtcccag gccagcgtgg ctgagtgtgc tggctggagg      120

cctctctctc tgcttcgagg gtagctgaga tccaccccgg aaaccggcag gatgaagggg      180

gcaagtgagg agaagctggc atctgtgtcc aacctggtca ctgtgtttga gaatagcagg      240

accccagaag cagcacccag aggccagagg ctagaggacg tgcatcaccg ccctgagtgc      300

aggcctcccg agtccccagg accacgggag aagacgaatg tcggggaggc cgtggggtct      360

gagcccagga cagtcagcag gaggtacctg aactccctga agaacaagct gtccagcgaa      420

gcctggagga aatcttgcca gcctgtgacc ctctcaggat cggggacgca ggagccagag      480

aagaagatcg tccaggagct gctggagaca gagcaggcct atgtggcgcg cctccacctg      540

ctagaccagg tgtttttcca ggagctgctg aagacagccc gcagcagcaa ggccttccca      600

gaggatgtgg tcagggtcat cttctccaac atctcctcca tctatcagtt ccattctcag      660

ttcttcctcc cagagctgca gcggcgcctg gacgactgga cagctaaccc ccgcatcggt      720

gacgtgatcc agaagctggc ccccttcctg aagatgtaca gtgagtatgt caagaacttt      780

gagcgagcgg ctgagctgct ggccacctgg accgacaagt ctccactctt ccaggaggtt      840

ctcactcgca tccagagcag cgaggcttcg ggcagcctga ccctgcagca ccacatgctg      900

gaaccagtgc agagaattcc acgttacgag ctgctgctca aggagtacat ccagaagctg      960

ccagcccagg ccccagacca ggccgatgcc cagaaagccc tggacatgat cttctcagct     1020

gcccagcact ccaatgcagc catcactgag atggagcggc tgcaggacct gtgggaggtg     1080

taccagcgcc tgggcctcga ggacgacata gtagacccct ctaacaccct gctccgtgag     1140

ggcccggtcc tcaagatctc cttccgccgc aacgacccca tggagcgcta ccttttcttg     1200

ttcaacaaca tgctgctcta ctgtgtgccc agggtgatcc aggtgggcgc ccagttccag     1260

gtgaggaccc gcatcgatgt ggccgggatg aaggtgcggg agctgatgga tgctgagttt     1320

ccccactcct tcctggtgtc cgggaagcag cgcaccctgg agctgcaagc ccggtcccag     1380

gaggaaatga tttcctggat gcaggccttc caagcagcca ttgaccaaat cgagaagcgg     1440

aatgaaacct tcaaggctgc ggcccagggg cctgagggag acatccagga gcaggagctg     1500

cagtctgagg agctgggcct ccgggcaccg cagtgggtcc gggacaagat ggtgaccatg     1560

tgcatgcgct gccaggagcc cttcaacgct ctgacgcgcc gtcgccacca ctgccgggcc     1620

tgcggctatg tggtgtgtgc caggtgctcc gactaccggg ccgaactgaa atacgacgac     1680

aacaggccca accgagtctg cctccactgc tacgcattcc tcactggaaa tgtgctgcct     1740

gaggccaagg aggacaagag gcggggcatc ctggagaaag ggtcctcagc cacgcctgac     1800

cagagcctga tgtgcagctt cctgcagctc atcggggaca agtggggcaa gagcggcccc     1860

cggggctggt gtgtgatccc tcgggatgac cccctcgtgc tctatgtcta tgctgcccct     1920

caggacatga gggctcacac ctccatcccc ctgctgggct accaggtgac tgttgggccc     1980

cagggggacc ctcgggtctt ccagctacag cagtcaggcc agctctacac cttcaaggcc     2040

gagacggagg agctgaaggg ccgctgggtg aaggccatgg agcgggcggc cagtggctgg     2100

agccccagct ggcccaacga tggggacctg tccgactgag ccactgccag ccgctctcct     2160

gcccacctct ccccaccctg aacccagctc ctgccacaga ctgaccctgt ggcctcagtg     2220

acccactgcc ccaagtggtg ctttcagaga attgattcag ccatctgcgc ccaggccacg     2280

tgtcccgatc tgggattaga aaatatgggt ccattccttt ctagaaaggg gacaaccaag     2340

tgtctcagtt tgccttgcgg ggagggggct cctgggccat gggacttcca gtgctaaaac     2400

tgggaaagcc ccaggtaacc ccggactggt ggtcaccata gtatggtttt tcatttgtat     2460

ctcctgggga gcttttaaag agtactggtg aaaaacacat agtaaattaa ttttaaaaat     2520

gtaaaaaaca atgcctgtac tgaagtacca ccaccgattt aaatgggctg agttggggga     2580

ggcatggggt cttttttttt ttttttttga gacagagtct tactctgttt cccaggctgg     2640

agtgcacaaa catggctcac tacagcctcg ctctcccggg ctccagtgat cctcccgcct     2700

cagcctccca agtagctggg attataggtg tgtgccactg tgccaagcta atttttttat     2760

tttttgtaga gatgggattt caccatgtta ctcaggctgg tctcaaactc ccagcctcaa     2820

gcgatgctcc cacctccacc tcccaaagtg ctgggattac aggcgtgagc caccatacct     2880

ggcgcatgca tattttttaa gagtacccac tggagtctaa tatatagcct gggttacctg     2940

ggatgaagaa taaagagagc aaactaccac aaccaatggt tgagcccctg tcaagtgcca     3000

gtcatgatag tagtaataat aataataaac atctattgga ccagg                     3045


<210>  825
<211>  655
<212>  PRT
<213>  Homo Sapiens

<400>  825

Met Lys Gly Ala Ser Glu Glu Lys Leu Ala Ser Val Ser Asn Leu Val 
1               5                   10                  15      


Thr Val Phe Glu Asn Ser Arg Thr Pro Glu Ala Ala Pro Arg Gly Gln 
            20                  25                  30          


Arg Leu Glu Asp Val His His Arg Pro Glu Cys Arg Pro Pro Glu Ser 
        35                  40                  45              


Pro Gly Pro Arg Glu Lys Thr Asn Val Gly Glu Ala Val Gly Ser Glu 
    50                  55                  60                  


Pro Arg Thr Val Ser Arg Arg Tyr Leu Asn Ser Leu Lys Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Arg Lys Ser Cys Gln Pro Val Thr Leu Ser Gly 
                85                  90                  95      


Ser Gly Thr Gln Glu Pro Glu Lys Lys Ile Val Gln Glu Leu Leu Glu 
            100                 105                 110         


Thr Glu Gln Ala Tyr Val Ala Arg Leu His Leu Leu Asp Gln Val Phe 
        115                 120                 125             


Phe Gln Glu Leu Leu Lys Thr Ala Arg Ser Ser Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asp Val Val Arg Val Ile Phe Ser Asn Ile Ser Ser Ile Tyr Gln Phe 
145                 150                 155                 160 


His Ser Gln Phe Phe Leu Pro Glu Leu Gln Arg Arg Leu Asp Asp Trp 
                165                 170                 175     


Thr Ala Asn Pro Arg Ile Gly Asp Val Ile Gln Lys Leu Ala Pro Phe 
            180                 185                 190         


Leu Lys Met Tyr Ser Glu Tyr Val Lys Asn Phe Glu Arg Ala Ala Glu 
        195                 200                 205             


Leu Leu Ala Thr Trp Thr Asp Lys Ser Pro Leu Phe Gln Glu Val Leu 
    210                 215                 220                 


Thr Arg Ile Gln Ser Ser Glu Ala Ser Gly Ser Leu Thr Leu Gln His 
225                 230                 235                 240 


His Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu 
                245                 250                 255     


Lys Glu Tyr Ile Gln Lys Leu Pro Ala Gln Ala Pro Asp Gln Ala Asp 
            260                 265                 270         


Ala Gln Lys Ala Leu Asp Met Ile Phe Ser Ala Ala Gln His Ser Asn 
        275                 280                 285             


Ala Ala Ile Thr Glu Met Glu Arg Leu Gln Asp Leu Trp Glu Val Tyr 
    290                 295                 300                 


Gln Arg Leu Gly Leu Glu Asp Asp Ile Val Asp Pro Ser Asn Thr Leu 
305                 310                 315                 320 


Leu Arg Glu Gly Pro Val Leu Lys Ile Ser Phe Arg Arg Asn Asp Pro 
                325                 330                 335     


Met Glu Arg Tyr Leu Phe Leu Phe Asn Asn Met Leu Leu Tyr Cys Val 
            340                 345                 350         


Pro Arg Val Ile Gln Val Gly Ala Gln Phe Gln Val Arg Thr Arg Ile 
        355                 360                 365             


Asp Val Ala Gly Met Lys Val Arg Glu Leu Met Asp Ala Glu Phe Pro 
    370                 375                 380                 


His Ser Phe Leu Val Ser Gly Lys Gln Arg Thr Leu Glu Leu Gln Ala 
385                 390                 395                 400 


Arg Ser Gln Glu Glu Met Ile Ser Trp Met Gln Ala Phe Gln Ala Ala 
                405                 410                 415     


Ile Asp Gln Ile Glu Lys Arg Asn Glu Thr Phe Lys Ala Ala Ala Gln 
            420                 425                 430         


Gly Pro Glu Gly Asp Ile Gln Glu Gln Glu Leu Gln Ser Glu Glu Leu 
        435                 440                 445             


Gly Leu Arg Ala Pro Gln Trp Val Arg Asp Lys Met Val Thr Met Cys 
    450                 455                 460                 


Met Arg Cys Gln Glu Pro Phe Asn Ala Leu Thr Arg Arg Arg His His 
465                 470                 475                 480 


Cys Arg Ala Cys Gly Tyr Val Val Cys Ala Arg Cys Ser Asp Tyr Arg 
                485                 490                 495     


Ala Glu Leu Lys Tyr Asp Asp Asn Arg Pro Asn Arg Val Cys Leu His 
            500                 505                 510         


Cys Tyr Ala Phe Leu Thr Gly Asn Val Leu Pro Glu Ala Lys Glu Asp 
        515                 520                 525             


Lys Arg Arg Gly Ile Leu Glu Lys Gly Ser Ser Ala Thr Pro Asp Gln 
    530                 535                 540                 


Ser Leu Met Cys Ser Phe Leu Gln Leu Ile Gly Asp Lys Trp Gly Lys 
545                 550                 555                 560 


Ser Gly Pro Arg Gly Trp Cys Val Ile Pro Arg Asp Asp Pro Leu Val 
                565                 570                 575     


Leu Tyr Val Tyr Ala Ala Pro Gln Asp Met Arg Ala His Thr Ser Ile 
            580                 585                 590         


Pro Leu Leu Gly Tyr Gln Val Thr Val Gly Pro Gln Gly Asp Pro Arg 
        595                 600                 605             


Val Phe Gln Leu Gln Gln Ser Gly Gln Leu Tyr Thr Phe Lys Ala Glu 
    610                 615                 620                 


Thr Glu Glu Leu Lys Gly Arg Trp Val Lys Ala Met Glu Arg Ala Ala 
625                 630                 635                 640 


Ser Gly Trp Ser Pro Ser Trp Pro Asn Asp Gly Asp Leu Ser Asp 
                645                 650                 655 


<210>  826
<211>  789
<212>  DNA
<213>  Homo Sapiens

<400>  826
gagaagagca ctgattggct gaggcagaaa agtgcccctg cctcggcgct ttcggttttg       60

gctgggatca tccgcggcgg ccgggctcgt ggggcgcctg gagtgagggt tctggttccc      120

gccggcgagg attgttaaaa tgagtcttcg gaagcaaacc cctagtgact tcttaaagca      180

aatcatcgga cgaccagttg tggtaaaatt aaattctgga gtggattatc gaggggtcct      240

ggcttgcctg gatggctaca tgaatatagc cctggagcag acagaagaat atgtaaatgg      300

acaactgaag aataagtatg gggatgcatt tatccgagga aacaatgtgt tgtacatcag      360

tacacagaag agacggatgt gaagacacca agagagcaac gcttttcata gttggatata      420

tttttttatg aattttttct aatttttgct tcttttgtga tacaatttgt cctcttttta      480

taatagttgg tgatttttca ctgacatgtg agtaagataa atgtatacaa ttgtggattt      540

aattgtgaaa tgttctttca cttgtaagtt tcagtcattt tcttttacct cgttgtcagt      600

gtacagaatg ctaaaataat taaaaaaaga caaaatatac ctcttcctac aagattattt      660

aacttaagtt tcgagaagtg tcatttcatt tgacttgctt ttcttatcca gctaaaatga      720

tgcatatatt ttatatattg tatggacata taattaaaac attttggagg aatcctcctt      780

tattgcaaa                                                              789


<210>  827
<211>  80
<212>  PRT
<213>  Homo Sapiens

<400>  827

Met Ser Leu Arg Lys Gln Thr Pro Ser Asp Phe Leu Lys Gln Ile Ile 
1               5                   10                  15      


Gly Arg Pro Val Val Val Lys Leu Asn Ser Gly Val Asp Tyr Arg Gly 
            20                  25                  30          


Val Leu Ala Cys Leu Asp Gly Tyr Met Asn Ile Ala Leu Glu Gln Thr 
        35                  40                  45              


Glu Glu Tyr Val Asn Gly Gln Leu Lys Asn Lys Tyr Gly Asp Ala Phe 
    50                  55                  60                  


Ile Arg Gly Asn Asn Val Leu Tyr Ile Ser Thr Gln Lys Arg Arg Met 
65                  70                  75                  80  


<210>  828
<211>  3311
<212>  DNA
<213>  Homo Sapiens

<400>  828
aaagcctcgg ctacttccga gggggtgagt ggcttcaccg ccggtccctt gcagcgctgc       60

ctttcgatct ctccacatct cggtggcgcg ggatctcaag atgcgcctcc acctgctcct      120

gctgctcgcg ctgtgcggtg caggcaccac cgccgcggag ctcagttaca gcttgcgtgg      180

caactggagc atctgcaatg ggaacggctc gctggagctg cccggggcgg tccctggctg      240

cgtgcacagc gccttgttcc agcagggcct gatccaggat tcttactaca gatttaatga      300

ccttaactac agatgggtct ctttggataa ctggacctat agcaaagaat ttaaaatccc      360

ctttgaaatt agcaaatggc aaaaagtaaa tttgattctt gagggagtgg atacggtttc      420

aaaaatcctg ttcaatgaag tcactattgg ggaaacagac aatatgttca atagatatag      480

ctttgatatt accaacgtgg tcagggacgt gaactccatt gagctgcgtt tccagtcagc      540

ggtgttgtat gcagcacagc agagcaaagc tcacactcgc taccaggttc ccccagactg      600

ccctccactt gtgcagaagg gtgaatgcca tgtcaacttt gttcggaagg agcaatgttc      660

ctttagttgg gactgggggc cttcctttcc tacccaggga atctggaaag atgttagaat      720

tgaagcctat aatatttgtc acctgaacta cttcacattt tccccaatat atgataagag      780

tgcccaggag tggaatctgg aaatagagtc tacatttgat gttgtcagct caaagccagt      840

tggtggtcaa gtgatcgtag ccatccctaa gttgcaaaca caacagacat acagcattga      900

acttcaacct gggaaaagga ttgttgagct atttgtgaac attagcaaga atattactgt      960

agaaacttgg tggcctcatg gacatggaaa ccagactggg tacaacatga ctgttctttt     1020

tgaactggat ggaggcttaa atattgaaaa atcagctaag gtttatttta ggacagtgga     1080

acttatagaa gagcctataa aagggtctcc tggtttgagt ttctatttca aaattaatgg     1140

atttcccata tttctaaaag gctcaaactg gatcccagca gattcattcc aggaccgagt     1200

aacctctgag ttgttacggc tccttttaca gtctgttgtg gatgctaata tgaatactct     1260

tcgggtttgg ggaggaggaa tttatgagca ggatgaattc tatgaactct gtgatgaact     1320

aggaataatg gtatggcagg attttatgtt tgcctgtgcc ctttatccaa ctgatcaggg     1380

cttcctggat tcagtgacag cagaagttgc ctaccagatc aagagactga aatctcatcc     1440

ttctatcatc atatggagtg gcaataatga aaatgaggag gcgctgatga tgaattggta     1500

tcatatcagt ttcactgacc ggccaatcta catcaaggac tatgtgacac tctatgtgaa     1560

aaacatcaga gagctcgtac tggcaggaga caagagtcgt ccttttatta cgtccagtcc     1620

tacaaatggg gctgaaactg ttgcagaagc ctgggtctct caaaacccta atagcaatta     1680

ttttggtgat gtacattttt atgactatat cagtgattgc tggaactgga aagttttccc     1740

aaaagctcga tttgcatctg aatatggata tcagtcctgg ccgtccttca gtacattaga     1800

aaaggtctcg tctacagagg actggtcttt caatagcaag ttttcacttc atcgacaaca     1860

tcacgaaggt ggtaacaaac aaatgcttta tcaggctgga cttcatttca aactccccca     1920

aagcacagat ccattacgca catttaaaga taccatctac cttactcagg tgatgcaggc     1980

ccagtgtgtc aaaacagaaa ctgaattcta ccgccgtagt cgcagcgaga tagtggatca     2040

gcaagggcac acgatggggg cactttattg gcagttgaat gacatctggc aagctccttc     2100

ctgggcttct cttgagtacg gaggaaagtg gaaaatgctt cattactttg ctcagaattt     2160

ctttgctcca ctgttgccag taggctttga gaatgaaaac acgttctata tctatggtgt     2220

gtcagatctt cactcggatt attcgatgac actcagtgtg agagtccata catggagctc     2280

cctggagccc gtgtgctctc gtgtgactga acgttttgtg atgaaaggag gagaggctgt     2340

ctgcctttat gaggagccag tgtctgaatt gctgaggaga tgtgggaatt gcacacggga     2400

aagctgtgtg gtttcctttt acctttcagc tgaccatgaa ctcctgagcc cgaccaacta     2460

ccacttcttg tcctcaccga aggaggccgt ggggctctgc aaggcgcaga tcactgccat     2520

catctctcag caaggtgaca tatttgtttt tgacctggag acctcagctg tcgctccctt     2580

tgtttggttg gatgtaggaa gcatcccagg gagatttagt gacaatggtt tcctcatgac     2640

tgagaagaca cgaactatat tattttaccc ttgggagccc accagcaaga atgagttgga     2700

gcaatctttt catgtgacct ccttaacaga tatttactga aggaatctag gttgtatttt     2760

cagtggacaa tgggaataaa gcatttctaa agcaccgact ggagaggaag gcaacagaga     2820

caaggagaga agccgagaga catgtctgcg tgctgccacg catttgagcg attgctctgt     2880

gaagagttgt acactgaaca ctttcagggg aggctgttta cccaggcaat gtcctcaaac     2940

aagcctgtgc cggggtgtcc tggaatctgt gccaggactg tgtttttagc ccttcacctc     3000

tcagctttag caggacatga accagttata acaagatggc cctgcagctg gttacaagaa     3060

tgtgacatgg caggatctat ggaaccaaat ggaaggtttt gaggtgatgt aggtctttca     3120

cagctagctt tggggaatac ggaatactca aataaagtgc tttgttatta tttcagaggg     3180

aatggcgatt gaaatgttac aacagagatt tcttggtggt agctatttgg gtaaaggtat     3240

atgggtattt ttctgtacat gtgaaattat ataaaaataa aagttatata aattacattg     3300

acaacttgat a                                                          3311


<210>  829
<211>  879
<212>  PRT
<213>  Homo Sapiens

<400>  829

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly 
                485                 490                 495     


Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu 
            500                 505                 510         


Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe 
        515                 520                 525             


Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys 
    530                 535                 540                 


Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp 
545                 550                 555                 560 


Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser 
                565                 570                 575     


Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn 
            580                 585                 590         


Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser 
        595                 600                 605             


Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val 
    610                 615                 620                 


Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser 
625                 630                 635                 640 


Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr 
                645                 650                 655     


Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu 
            660                 665                 670         


Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe 
        675                 680                 685             


Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile 
    690                 695                 700                 


Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val 
705                 710                 715                 720 


Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr 
                725                 730                 735     


Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu 
            740                 745                 750         


Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser 
        755                 760                 765             


Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro 
    770                 775                 780                 


Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys 
785                 790                 795                 800 


Lys Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val 
                805                 810                 815     


Phe Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val 
            820                 825                 830         


Gly Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu 
        835                 840                 845             


Lys Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn 
    850                 855                 860                 


Glu Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
865                 870                 875                 


<210>  830
<211>  1759
<212>  DNA
<213>  Homo Sapiens

<400>  830
aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt tgttcctgct       60

gccaggctcc actgagggga acggggacct gtctgaagag aagatgcccc tgctgacact      120

ctacctgctc ctcttctggc tctcaggcta ctccattgtc actcaaatca ccggtccaac      180

aacagtgaat ggcttggagc ggggctcctt gaccgtgcag tgtgtttaca gatcaggctg      240

ggagacctac ttgaagtggt ggtgtcgagg agctatttgg cgtgactgca agatccttgt      300

taaaaccagt gggtcagagc aggaggtgaa gagggaccgg gtgtccatca aggacaatca      360

gaaaaaccgc acgttcactg tgaccatgga ggatctcatg aaaactgatg ctgacactta      420

ctggtgtgga attgagaaaa ctggaaatga ccttggggtc acagttcaag tgaccattga      480

cccagcacca gtcacccaag aagaaactag cagctcccca actctgaccg gccaccactt      540

ggacaacagg cacaagctcc tgaagctcag tgtcctcctg cccctcatct tcaccatatt      600

gctgctgctt ttggtggccg cctcactctt ggcttggagg atgatgaagt accagcagaa      660

agcagccggg atgtccccag agcaggtact gcagcccctg gagggcgacc tctgctatgc      720

agacctgacc ctgcagctgg ccggaacctc cccgcaaaag gctaccacga agctttcctc      780

tgcccaggtt gaccaggtgg aagtggaata tgtcaccatg gcttccttgc cgaaggagga      840

catttcctat gcatctctga ccttgggtgc tgaggatcag gaaccgacct actgcaacat      900

gggccacctc agtagccacc tccccggcag gggccctgag gagcccacgg aatacagcac      960

catcagcagg ccttagcctg cactccaggc tccttcttgg accccaggct gtgagcacac     1020

tcctgcctca tcgaccgtct gccccctgct cccctcatca ggaccaaccc ggggactggt     1080

gcctctgcct gatcagccag cattgcccct agctctgggt tgggcttggg gccaagtctc     1140

agggggcttc taggagttgg ggttttctaa acgtcccctc ctctcctaca tagttgagga     1200

gggggctagg gatatgctct ggggctttca tgggaatgat gaagatgata atgagaaaaa     1260

tgttatcatt attatcatga agtaccatta tcgtaataca atgaaccttt atttattgcc     1320

taccacatgt tatgggctga ataatggccc ccaaagatat ctgtgtccta atcctcagaa     1380

cctgtgactg ttaccttctg tggcagaaag ggacagtgca gatgtatgta agttaaggac     1440

tttgagatag agaggttatt cttgctgatt caggtgggcc caaaatatca ccacaagggt     1500

cctcataaga aagaggccag aaggtcaaag aggtagagac aaagtgatga tggaagtgga     1560

cgtgggtgtg acgtgagcag gggccatgaa tgccgcagcc ttcagatgcc agaaagggaa     1620

aggaatggat tcccctgcct ggagcctcca aaagaaacca gccctgccca cgccttgact     1680

tgagcccatt gaaactgatc ttgagctcct ggcctccaga attgcaggag aataaatttg     1740

tgttgttttt aatgagcca                                                  1759


<210>  831
<211>  290
<212>  PRT
<213>  Homo Sapiens

<400>  831

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  832
<211>  2723
<212>  DNA
<213>  Homo Sapiens

<400>  832
agtctgagcc cagagagccg cggggaccat ggagccggtg ccgctgcagg acttcgtgcg       60

cgccttggac cccgcctccc tcccgcgcgt gctgcgggtc tgctcggggg tctacttcga      120

gggctccatc tatgagatct ctgggaatga gtgctgcctc tccacggggg acctgatcaa      180

ggtcacccag gtccgcctcc agaaggtggt ctgtgagaac ccgaagacca gccagaccat      240

ggagctcgcc cccaacttcc agggctactt cacccccctc aacaccccac agagctatga      300

aaccctggag gagctggtct ctgccacaac tcagagctcc aagcagctgc ccacttgctt      360

catgtcgacc cacaggattg tcacagaggg cagggtggtg actgaggacc agctcctcat      420

gcttgaggct gtggtgatgc acctcgggat ccgctctgcc cgctgtgtcc tgggcatgga      480

gggtcagcag gtcatcctgc acctgcccct atcccagaag gggcccttct ggacatggga      540

gcctagtgcc cctcgaactc tgctccaggt cctacaggat ccagccctga aagacctcgt      600

cctcacctgc cccaccctgc cctggcattc cctgatcctg cggccccagt atgagatcca      660

agccatcatg cacatgcgca ggaccattgt caagatccct tctaccctgg aggtcgacgt      720

ggaggacgtc accgcctcct cccggcacgt ccactttatc aaaccgctgc tgctgagcga      780

ggtcctggcc tgggaaggcc ctttccccct gtccatggag atcctggagg ttcctgaggg      840

ccgccccatc ttcctcagcc cgtgggtggg ctccttgcaa aaaggccaga ggctttgcgt      900

ctatggccta gcctcaccac cctggcgggt cctggcctca agcaagggcc gcaaggtgcc      960

caggcacttc ctggtgtcag ggggctacca aggcaagctg cggcggcggc caagggagtt     1020

ccccacggcc tatgacctcc taggtgcttt ccagccaggc cggccactcc gggtggtggc     1080

cacaaaggac tgtgagggcg agagggagga gaatcccgag ttcacgtccc tggctgtggg     1140

tgaccggctg gaggtgctgg ggcctggcca ggcccatggg gcccagggca gtgacgtgga     1200

tgtcttggtt tgtcagcggc tgagtgacca ggctggggag gatgaggagg aagagtgcaa     1260

agaggaggca gagagcccag agcgggtcct gctgcccttc cacttccctg gcagtttcgt     1320

ggaggagatg agtgacagcc ggcgctacag cctggcagat ctgactgccc agttttcact     1380

gccttgtgag gtcaaggtgg tggccaagga caccagccac cccactgacc ctctgacctc     1440

cttcctgggc ctgcggctgg aggagaagat cacagagcca ttcttggtgg tgagcctaga     1500

ctctgagcct gggatgtgct ttgagatccc tccccggtgg ctggacctga ctgttgtgaa     1560

ggccaagggg cagccagact tgccagaggg gtctctcccc atagccacag tggaggagct     1620

gacagacacc ttctattatc gtcttcggaa gttaccagcc tgtgagatcc aagccccccc     1680

acccaggccc cctaaaaatc agggcctcag caagcagagg agacacagca gtgagggagg     1740

cgtcaagtct tctcaagtct taggattgca gcaacacgct cggctgccca aacccaaggc     1800

gaagaccttg ccagagttca tcaaggatgg ctccagtacg tacagcaaga ttcctgccca     1860

caggaagggc cacaggcccg ctaagcccca aaggcaggat ctagatgatg atgaacatga     1920

ttatgaagaa atacttgagc aatttcagaa aaccatctaa gtgctggagg aaccacgctt     1980

cctaactgct gcttctcagg gaatccgaca ccagccaacc attttaagcc tctaaaagac     2040

ctcgggcaag tctcacagaa actgagctgc agacggggag tagctttgtg gaaactgatt     2100

tgatggacac tgcaccagct tccttcaggt tctagattct tgctacttag ggcgggctgg     2160

tttggaccta acatctcgca cgtgactccc tcagcctcag agccttggga tgcagagcag     2220

ctggcagggt tcctctcaat cctgcaaccc cagctgtccc accggtggat gcagagggga     2280

atccgaggcc atcaaccttg gtgacagcag cgcagtgcca atgctgatca cactgcatgg     2340

gagattttgt taacgtctgc cacccccact ctcaccccca agctctaagc ccccgggagg     2400

cctggactgt cttcctcatc tctgtagcac caagcctgat agatctgtat atggtaaaca     2460

ggggtttaac cacatgtggt taacatggat taatgtggga acttggcttc aagaacacaa     2520

ccttaggacc ttgggcccca aaagctggtg gtgaaatgag gaggagccaa tttaagaaga     2580

cccttatgga gacctgaggc tgcagaaact ggtaggtttc atcaggtggt taaagtcgtc     2640

aaagttgtaa gtgactaacc aagattattt cattttaaaa ccatagaata aaaatgacac     2700

ctgagcttct ctatgaatga aaa                                             2723


<210>  833
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  833

Met Glu Pro Val Pro Leu Gln Asp Phe Val Arg Ala Leu Asp Pro Ala 
1               5                   10                  15      


Ser Leu Pro Arg Val Leu Arg Val Cys Ser Gly Val Tyr Phe Glu Gly 
            20                  25                  30          


Ser Ile Tyr Glu Ile Ser Gly Asn Glu Cys Cys Leu Ser Thr Gly Asp 
        35                  40                  45              


Leu Ile Lys Val Thr Gln Val Arg Leu Gln Lys Val Val Cys Glu Asn 
    50                  55                  60                  


Pro Lys Thr Ser Gln Thr Met Glu Leu Ala Pro Asn Phe Gln Gly Tyr 
65                  70                  75                  80  


Phe Thr Pro Leu Asn Thr Pro Gln Ser Tyr Glu Thr Leu Glu Glu Leu 
                85                  90                  95      


Val Ser Ala Thr Thr Gln Ser Ser Lys Gln Leu Pro Thr Cys Phe Met 
            100                 105                 110         


Ser Thr His Arg Ile Val Thr Glu Gly Arg Val Val Thr Glu Asp Gln 
        115                 120                 125             


Leu Leu Met Leu Glu Ala Val Val Met His Leu Gly Ile Arg Ser Ala 
    130                 135                 140                 


Arg Cys Val Leu Gly Met Glu Gly Gln Gln Val Ile Leu His Leu Pro 
145                 150                 155                 160 


Leu Ser Gln Lys Gly Pro Phe Trp Thr Trp Glu Pro Ser Ala Pro Arg 
                165                 170                 175     


Thr Leu Leu Gln Val Leu Gln Asp Pro Ala Leu Lys Asp Leu Val Leu 
            180                 185                 190         


Thr Cys Pro Thr Leu Pro Trp His Ser Leu Ile Leu Arg Pro Gln Tyr 
        195                 200                 205             


Glu Ile Gln Ala Ile Met His Met Arg Arg Thr Ile Val Lys Ile Pro 
    210                 215                 220                 


Ser Thr Leu Glu Val Asp Val Glu Asp Val Thr Ala Ser Ser Arg His 
225                 230                 235                 240 


Val His Phe Ile Lys Pro Leu Leu Leu Ser Glu Val Leu Ala Trp Glu 
                245                 250                 255     


Gly Pro Phe Pro Leu Ser Met Glu Ile Leu Glu Val Pro Glu Gly Arg 
            260                 265                 270         


Pro Ile Phe Leu Ser Pro Trp Val Gly Ser Leu Gln Lys Gly Gln Arg 
        275                 280                 285             


Leu Cys Val Tyr Gly Leu Ala Ser Pro Pro Trp Arg Val Leu Ala Ser 
    290                 295                 300                 


Ser Lys Gly Arg Lys Val Pro Arg His Phe Leu Val Ser Gly Gly Tyr 
305                 310                 315                 320 


Gln Gly Lys Leu Arg Arg Arg Pro Arg Glu Phe Pro Thr Ala Tyr Asp 
                325                 330                 335     


Leu Leu Gly Ala Phe Gln Pro Gly Arg Pro Leu Arg Val Val Ala Thr 
            340                 345                 350         


Lys Asp Cys Glu Gly Glu Arg Glu Glu Asn Pro Glu Phe Thr Ser Leu 
        355                 360                 365             


Ala Val Gly Asp Arg Leu Glu Val Leu Gly Pro Gly Gln Ala His Gly 
    370                 375                 380                 


Ala Gln Gly Ser Asp Val Asp Val Leu Val Cys Gln Arg Leu Ser Asp 
385                 390                 395                 400 


Gln Ala Gly Glu Asp Glu Glu Glu Glu Cys Lys Glu Glu Ala Glu Ser 
                405                 410                 415     


Pro Glu Arg Val Leu Leu Pro Phe His Phe Pro Gly Ser Phe Val Glu 
            420                 425                 430         


Glu Met Ser Asp Ser Arg Arg Tyr Ser Leu Ala Asp Leu Thr Ala Gln 
        435                 440                 445             


Phe Ser Leu Pro Cys Glu Val Lys Val Val Ala Lys Asp Thr Ser His 
    450                 455                 460                 


Pro Thr Asp Pro Leu Thr Ser Phe Leu Gly Leu Arg Leu Glu Glu Lys 
465                 470                 475                 480 


Ile Thr Glu Pro Phe Leu Val Val Ser Leu Asp Ser Glu Pro Gly Met 
                485                 490                 495     


Cys Phe Glu Ile Pro Pro Arg Trp Leu Asp Leu Thr Val Val Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Asp Leu Pro Glu Gly Ser Leu Pro Ile Ala Thr Val 
        515                 520                 525             


Glu Glu Leu Thr Asp Thr Phe Tyr Tyr Arg Leu Arg Lys Leu Pro Ala 
    530                 535                 540                 


Cys Glu Ile Gln Ala Pro Pro Pro Arg Pro Pro Lys Asn Gln Gly Leu 
545                 550                 555                 560 


Ser Lys Gln Arg Arg His Ser Ser Glu Gly Gly Val Lys Ser Ser Gln 
                565                 570                 575     


Val Leu Gly Leu Gln Gln His Ala Arg Leu Pro Lys Pro Lys Ala Lys 
            580                 585                 590         


Thr Leu Pro Glu Phe Ile Lys Asp Gly Ser Ser Thr Tyr Ser Lys Ile 
        595                 600                 605             


Pro Ala His Arg Lys Gly His Arg Pro Ala Lys Pro Gln Arg Gln Asp 
    610                 615                 620                 


Leu Asp Asp Asp Glu His Asp Tyr Glu Glu Ile Leu Glu Gln Phe Gln 
625                 630                 635                 640 


Lys Thr Ile 
            


<210>  834
<211>  7014
<212>  DNA
<213>  Homo Sapiens

<400>  834
cggggaccgc gacgagcccg ggtcgccgtt ggcagcagca gcagcaacac cagcagcagc       60

agcagccccg gcggcggcgc ggaccccgag cgcccgggcg caccccggct tcccggagcg      120

cgacgcggcg gcagcagccc cggtgcggcc gcgcgcgcct taggctcggc cccgcggctc      180

ggggaccccg actcccggcc cagcgagcgc gtcccccggc gccgcccgag agcccgagga      240

ggcagcggcc gcaggcagcc ggggaggggg gcggccaccg cccgcgccgg gcatcctcag      300

gagccccaga gcgcggaggg cgcggcgccg ccgagcggtg ctggcccccg cgggcctccc      360

cggaccttcc ccaccgcctg ggcccgaggg acgcgtgatc gggcgggcgg ccgggcgcaa      420

gggtgggagg gagccgcccc cgcccgcgcc ccctccgccc ctcgccccaa cccctgggcg      480

ccgggcccgg gccgcgcggc ctgaagcgcc cgcgatggcg agcccgccgc ggcacgggcc      540

gcccgggccg gcgagcggag acggccccaa cctcaacaac aacaacaaca acaacaacca      600

cagcgtgcgc aagtgcggct acctgcgcaa gcagaagcat ggccacaagc gcttcttcgt      660

gctgcgcgga cccggcgcgg gcggcgacga ggcgacggcg ggcggggggt cggcgccgca      720

accgccgcgg ctcgagtact acgagagcga gaaaaagtgg cggagcaagg caggcgcgcc      780

gaaacgggtg atcgctctcg actgctgcct gaacatcaac aagcgcgccg acgccaagca      840

caagtacctg atcgccctct acaccaagga cgagtacttc gccgtggccg ccgagaacga      900

gcaggagcag gagggctggt accgcgcgct caccgacctg gtcagcgagg gccgcgcggc      960

cgccggagac gcgccccccg ccgccgcgcc cgccgcgtcc tgcagcgcct ccctgcccgg     1020

cgccctgggc ggctctgccg gcgccgccgg ggccgaggac agctacgggc tggtggctcc     1080

cgccacggcc gcctaccgtg aggtgtggca ggtgaacctg aagcccaagg gtctgggcca     1140

gagcaagaac ctgacggggg tgtaccgtct gtgcctgtct gcgcgcacca tcggcttcgt     1200

gaagctcaac tgcgagcagc cgtcggtgac gctgcagctc atgaacatcc gccgctgcgg     1260

ccactcggac agcttcttct tcatcgaggt gggccgctcg gccgtcacag gccccggcga     1320

gctgtggatg caggcggacg actcggtggt ggcgcagaac atccacgaga ccatcctgga     1380

ggccatgaag gcgctcaagg agctcttcga gttccggccg cgcagtaaga gccaatcgtc     1440

ggggtcgtcg gccacgcacc ccatcagcgt ccccggcgcg cgccgccacc accacctggt     1500

caacctgccc cccagccaga cgggcctggt gcgccgctcg cgcaccgaca gcctggccgc     1560

caccccgccg gcggccaagt gcagctcgtg ccgggtgcgc accgccagcg agggcgacgg     1620

cggcgcggcg gcgggagcgg cggccgcggg cgccaggccg gtgtcggtgg ctgggagccc     1680

cctgagcccc gggccggtgc gcgcgcccct gagccgctcg cacaccctga gcggcggctg     1740

cggcggccgc gggagcaagg tggcgctgct gccggcaggg ggcgcgctgc aacacagccg     1800

ctccatgtcc atgcccgtgg cgcactcgcc gcccgccgcc accagccccg gctccctgtc     1860

gtccagcagc ggccacggct cgggctccta cccgccgccg cccggcccgc acccgcctct     1920

gccgcatccg ctgcaccacg gccccggcca gcggccctcc agcggcagcg cctccgcctc     1980

gggctccccc agcgaccccg gcttcatgtc cctggacgag tacggctcca gcccaggcga     2040

cctgcgcgcc ttctgcagcc accgaagcaa cacgcccgag tccatcgcgg agacgccccc     2100

ggcccgagac ggcggcggcg gcggtgagtt ctacgggtac atgaccatgg acaggcccct     2160

gagccactgt ggccgctcct accgccgggt ctcgggggac gcggcccagg acctggaccg     2220

agggctgcgc aagaggacct actccctgac cacgccagcc cggcagcggc cggtgcccca     2280

gccctcctct gcctcgctgg atgaatacac cctgatgcgg gccaccttct cgggcagcgc     2340

gggccgcctc tgcccgtcct gccccgcgtc ctctcccaag gtggcctacc acccctaccc     2400

agaggactac ggagacatcg agatcggctc ccacaggagc tccagcagca acctgggggc     2460

agacgacggc tacatgccca tgacgcccgg cgcggccctc gcgggcagtg ggagcggcag     2520

ctgcaggagc gacgactaca tgcccatgag ccccgccagc gtgtccgccc ccaagcagat     2580

cttgcagccc agggccgccg ccgccgccgc cgccgccgtg ccttctgcgg ggcctgcggg     2640

gccagcaccc acctctgcgg cgggcaggac attcccggcg agcgggggcg gctacaaggc     2700

cagctcgccc gccgagagct cccccgagga cagtgggtac atgcgcatgt ggtgcggttc     2760

caagctgtcc atggagcatg cagatggcaa gctgctgccc aacggggact acctcaacgt     2820

gtcccccagc gacgcggtca ccacgggcac cccgcccgac ttcttctccg cagccctgca     2880

ccccggcggg gagccgctca ggggcgttcc cggctgctgc tacagctcct tgccccgctc     2940

ctacaaggcc ccctacacct gtggcgggga cagcgaccag tacgtgctca tgagctcccc     3000

cgtggggcgc atcctggagg aggagcgtct ggagcctcag gccacgccag ggcccagcca     3060

ggcggccagc gccttcgggg ccggccccac gcagccccct caccctgtag tgccttcgcc     3120

cgtgcggcct agcggcggcc gcccggaggg cttcttgggc cagcgcggcc gggcggtgag     3180

gcccacgcgc ctgtccctgg aggggctgcc cagcctgccc agcatgcacg agtacccact     3240

gccaccggag cccaagagcc ccggcgagta catcaacatc gactttggcg agcccggggc     3300

ccgcctgtcg ccgcccgcgc ctcccctgct ggcgtcggcg gcctcgtcct cctcgctctt     3360

gtccgccagc agcccggcct cgtcgctggg ctcaggcacc ccgggcacca gcagcgacag     3420

ccggcagcgg tctccgctct ccgactacat gaacctcgac ttcagctccc ccaagtctcc     3480

taagccgggc gccccgagcg gccaccccgt gggctccttg gacggcctcc tgtcccccga     3540

ggcctcctcc ccgtatccgc cgttgccccc gcgtccgtcc gcgtccccgt cgtcgtctct     3600

gcagccgccg ccaccgccgc cggccccggg ggagctgtac cgcctgcccc ccgcctcggc     3660

cgttgccacc gcccagggcc cgggcgccgc ctcatcgttg tcctcggaca ccggggacaa     3720

tggtgactac accgagatgg cttttggtgt ggccgccacc ccgccgcaac ctatcgcggc     3780

ccccccgaag ccagaagctg cccgcgtggc cagcccgacg tcgggcgtga agaggctgag     3840

cctcatggag caggtgtcgg gagtcgaggc cttcctgcag gccagccagc ccccggaccc     3900

ccaccgcggc gccaaggtca tccgcgcaga cccgcagggg ggccgccgcc gccacagttc     3960

cgagaccttc tcctccacca cgacggtcac ccccgtgtcc ccgtccttcg cccacaaccc     4020

caagcgccac aactcggcct ccgtggaaaa tgtctctctc aggaaaagca gcgagggcgg     4080

cgtgggtgtc ggccctggag ggggcgacga gccgcccacc tccccacgac agttgcagcc     4140

ggcgccccct ttggcaccgc agggccggcc gtggaccccg ggtcagcccg ggggcttggt     4200

cggttgtcct gggagcggtg gatcgcccat gcgcagagag acctctgccg gcttccagaa     4260

tggtctcaac tacatcgcca tcgacgtgag ggaggagccc gggctgccac cccagccgca     4320

gccgccgccg ccgccgcttc ctcagccggg agacaagagc tcctggggcc ggacccgaag     4380

cctcgggggt ctcatcagcg ctgtgggcgt cggcagcacc ggcggcgggt gcggggggcc     4440

gggtcccggt gccctgcccc ctgccaacac ctacgccagc attgacttct tgtcccacca     4500

cttgaaggag gccaccatcg tgaaagagtg aagatctgtc tggctttatc accaggatgt     4560

cacatgtcag agagtatcat taaaagaaga cgctcagcac tgtttcagcc cgaagctgct     4620

tgcagttttc ttttggatct gagcaatgac tgtgtttgga aacatctgtg gactctgtta     4680

gatgaggcac caacaaggca aggtcacctg cctctttccc ttgttcccgg atggggcatt     4740

catcattgtg ctgtttgcgt tttgttttgt tttgttttaa caaaattagc tgaagaagtt     4800

attctcaaga aaattggatg ttttcattgg ccttcttaaa ttgtggccag tgtcttttaa     4860

tttcttcttc ttttcctttt ggcaaagcag atataaccct cagcatgcta ggagagtgca     4920

cccgtaccta tggaagtggt aaaatctggt atttactggc ttacactcaa aacgaccaca     4980

gtcctacctc agttcaaggt aaagccggat ttccgtggcg ggggtcccac aggacctcct     5040

gtagtagccc ctgcgctgtg tgtctggagc gcggtcctcg gccttattga aatggtccaa     5100

gtagacagct gcttgttgga ttccagtgca ggtacctgcg atgtttacgt ccacaccgag     5160

cccagtgtgg gactgacatt tctcaatgga agtgaaattt gggattggac tttgaagacg     5220

gattactaaa taataattat tatatgtaac tgaagcaacc tacttttgaa aatcaactgt     5280

attgggtagt gggaggtggg agggaagggc tttgggaagg ggatgaatat ctctttttac     5340

ctttaacaga cttgtttaat cttctcgatg tagatgttta tgtaggtact tcacattgca     5400

aacgcctttt attctattta caagctcaga tgtctctgct ctcctgaatc ttgggcatgc     5460

ctttctgtaa ccaaaaatcc ctgtaggcgt gctagcaatt ccagggtggt ccgggtttgg     5520

cagatttgat ttttaaaaaa cgtattatct ttaataaaat gttattatgt caaccagtga     5580

ggctgccctg aacaaaaaaa acaaaaagaa aaaaaaaaaa ggaaagaaag aaactgataa     5640

aaagaggcat tccagcccct atgttattga tggaaaaaga aaaagaagaa aagcaatctc     5700

gcagtacatg ttacttgtcg aaaaaattcc ggacaagact acccttgttt tatgttttca     5760

gtattctgaa aataccagtg tgtggcagtt ctcgcagatg ttacctaaaa ctgctgaact     5820

tgaccggcag aatgttctgc cgttttctgc tccctcgaca cttgattgga gggctgtcga     5880

cctctcctcc cgtgggggct tccccagtgc ctatcttctc tgatagtcat ggagaggtta     5940

cactaattca ttggagatgt aagttgttgg ttttgttttg ttttgttttt agaaaaatat     6000

atataaatat ataatagata tctatcgcta tagaataatg cattaataaa atgaggcttt     6060

tttagaggaa gaccaaaaaa ttcaatgtct taaaaatata tttaatggca atgcaaaagt     6120

cttcctgctt ccgtgctgaa ctttagaaca gaggattgta ttgcaagaca aagttgaatg     6180

taaagtgatc tccctgaaca tttttaaggt tttacttttc tgaaattata catcacagca     6240

gtgcataggc catataatgt tagctggaag gtcaatttca gtgtatgata tactttatta     6300

agatgtataa aaatcctgaa gtttttattt agttttggga ataggcatca atgggtggta     6360

tttgctttgt aactcccccc aggtacgata gggactgaat atggaccctg ctgaaagcag     6420

tgtattgacg catatttaac tcgccctcta tccgtagagt agtcatgaca ctatacagat     6480

ggttcgtgtt catactgcag cttaaaacaa gcaaaataca cagatgataa tatgctaaat     6540

tttcctctat cctgtacatt tcacaaaaag gcatatgcaa tatttacatt tttaatttag     6600

tttacagaat ggaaccaaaa tgtataaatg ttatgtttgc taaaacttca caatgtatat     6660

tgggtctttg tacattttgc ctgacttacc ttaaatttaa aatatttttt gctatataaa     6720

ctttaacagt tattaaacag tgttttcttt ttgggtacgt attgtttctg gatatcaaga     6780

tgttaaatat atttcttgct attgtgatat gacaagagac ttaacttatc ttgctctgtc     6840

ttccactgta cacgctgtat ataggggtca atgtgatgct gctggagacg agaataaact     6900

ggactagaat agtgcattgt atttagtctg tattgatcat ggatgccctc cttaatagcc     6960

atatgcaata aaataaagta cattatttat gaaatgaaaa aaaaaaaaaa aaaa           7014


<210>  835
<211>  1338
<212>  PRT
<213>  Homo Sapiens

<400>  835

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  836
<211>  2113
<212>  DNA
<213>  Homo Sapiens

<400>  836
tcccaatccc ggggcggccg ggcgggggtg ggcagggggc gtgaggccgc ccctgcgtcc       60

cgggggcccc ccgaaaacgc gctccgggtg cccggtccct ccgctgcgcc ctgccgccgt      120

cctcccgggg gtctcgggcg gccgcggccg tgtccttcgc gtcccggcgg cgcggcggga      180

ggggccggcg tgacgcagcg gttgctacgg gccgccctta taaataaccg ggctcaggag      240

aaactttagc gagtcagagc cgcgcacggg actgggaagg ggacccaccc gagggtccag      300

ccaccagccc cctcactaat agcggccacc ccggcagcgg cggcagcagc agcagcgacg      360

cagcggcgac agctcagagc agggaggccg cgccacctgc gggccggccg gagcgggcag      420

ccccaggccc cctccccggg cacccgcgtt catgcaacgc ctggtggcct gggacccagc      480

atgtctcccc ctgccgccgc cgccgcctgc ctttaaatcc atggaagtgg ccaacttcta      540

ctacgaggcg gactgcttgg ctgctgcgta cggcggcaag gcggcccccg cggcgccccc      600

cgcggccaga cccgggccgc gcccccccgc cggcgagctg ggcagcatcg gcgaccacga      660

gcgcgccatc gacttcagcc cgtacctgga gccgctgggc gcgccgcagg ccccggcgcc      720

cgccacggcc acggacacct tcgaggcggc tccgcccgcg cccgcccccg cgcccgcctc      780

ctccgggcag caccacgact tcctctccga cctcttctcc gacgactacg ggggcaagaa      840

ctgcaagaag ccggccgagt acggctacgt gagcctgggg cgcctggggg ccgccaaggg      900

cgcgctgcac cccggctgct tcgcgcccct gcacccaccg cccccgccgc cgccgccgcc      960

cgccgagctc aaggcggagc cgggcttcga gcccgcggac tgcaagcgga aggaggaggc     1020

cggggcgccg ggcggcggcg caggcatggc ggcgggcttc ccgtacgcgc tgcgcgctta     1080

cctcggctac caggcggtgc cgagcggcag cagcgggagc ctctccacgt cctcctcgtc     1140

cagcccgccc ggcacgccga gccccgctga cgccaaggcg cccccgaccg cctgctacgc     1200

gggggccgcg ccggcgccct cgcaggtcaa gagcaaggcc aagaagaccg tggacaagca     1260

cagcgacgag tacaagatcc ggcgcgagcg caacaacatc gccgtgcgca agagccgcga     1320

caaggccaag atgcgcaacc tggagacgca gcacaaggtc ctggagctca cggccgagaa     1380

cgagcggctg cagaagaagg tggagcagct gtcgcgcgag ctcagcaccc tgcggaactt     1440

gttcaagcag ctgcccgagc ccctgctcgc ctcctccggc cactgctagc gcggcccccg     1500

cgcgcgtccc cctgccggcc ggggctgaga ctccggggag cgcccgcgcc cgcgccctcg     1560

cccccgcccc cggcggcgcc ggcaaaactt tggcactggg gcacttggca gcgcggggag     1620

cccgtcggta attttaatat tttattatat atatatatct atatttttgt ccaaaccaac     1680

cgcacatgca gatggggctc ccgcccgtgg tgttatttaa agaagaaacg tctatgtgta     1740

cagatgaatg ataaactctc tgcttctccc tctgcccctc tccaggcgcc ggcgggcggg     1800

ccggtttcga agttgatgca atcggtttaa acatggctga acgcgtgtgt acacgggact     1860

gacgcaaccc acgtgtaact gtcagccggg ccctgagtaa tcgcttaaag atgttcctac     1920

gggcttgttg ctgttgatgt tttgttttgt tttgtttttt ggtctttttt tgtattataa     1980

aaaataatct atttctatga gaaaagaggc gtctgtatat tttgggaatc ttttccgttt     2040

caagcattaa gaacactttt aataaacttt tttttgagaa tggttacaaa gccttttggg     2100

ggcagtaaaa aaa                                                        2113


<210>  837
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  837

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210>  838
<211>  2571
<212>  DNA
<213>  Homo Sapiens

<400>  838
acccgccacc cgccggccct tccgcctcac tcagcggcgc cactgagagg gacgggcgcc       60

ggccatggag cgcacagcag gcaaagagct ggccctggca ccgctgcagg actggggtga      120

agagaccgag gacggcgcgg tgtacagtgt ctccctgcgg cggcagcgca gtcagcgcag      180

gagcccggcg gagggccccg ggggcagcca ggctcccagc cccattgcca ataccttcct      240

ccactatcga accagcaagg tgagggtgct gagggcagcg cgcctggagc ggctggtggg      300

agagttggtg tttggagacc gtgagcagga ccccagcttc atgcccgcct tcctggccac      360

ctaccggacc tttgtaccca ctgcctgcct gctgggcttt ctgctgccac caatgccacc      420

gcccccacct cccggggtag agatcaagaa gacagcggta caagatctga gcttcaacaa      480

gaacctgagg gctgtggtgt cagtgctggg ctcctggctg caggaccacc ctcaggattt      540

ccgagacccc cctgcccatt cggacctggg cagtgtccga acctttctgg gctgggcggc      600

cccagggagt gctgaggctc aaaaagcaga gaagcttctg gaagattttt tggaggaggc      660

tgagcgagag caggaagagg agccgcctca ggtgtggaca ggacctccca gagttgccca      720

aacttctgac ccagactctt cagaggcctg cgcggaggaa gaggaagggc tcatgcctca      780

aggtccccag ctcctggact tcagcgtgga cgaggtggcc gagcagctga ccctcataga      840

cttggagctc ttctccaagg tgaggctcta cgagtgcttg ggctccgtgt ggtcgcagag      900

ggaccggccg ggggctgcag gcgcctcccc cactgtgcgc gccaccgtgg cccagttcaa      960

caccgtgacc ggctgtgtgc tgggttccgt gctcggagca ccgggcttgg ccgccccgca     1020

gagggcgcag cggctggaga agtggatccg catcgcccag cgctgccgag aactgcggaa     1080

cttctcctcc ttgcgcgcca tcctgtccgc cctgcaatct aaccccatct accggctcaa     1140

gcgcagctgg ggggcagtga gccgggaacc gctatctact ttcaggaaac tttcgcagat     1200

tttctccgat gagaacaacc acctcagcag cagagagatt cttttccagg aggaggccac     1260

tgagggatcc caagaagagg acaacacccc aggcagcctg ccctcaaaac cacccccagg     1320

ccctgtcccc taccttggca ccttccttac ggacctggtt atgctggaca cagccctgcc     1380

ggatatgttg gagggggatc tcattaactt tgagaagagg aggaaggagt gggagatcct     1440

ggcccgcatc cagcagctgc agaggcgctg tcagagctac accctgagcc cccacccgcc     1500

catcctggct gccctgcatg cccagaacca gctcaccgag gagcagagct accggctctc     1560

ccgggtcatt gagccaccag ctgcctcctg ccccagctcc ccacgcatcc gacggcggat     1620

cagcctcacc aagcgtctca gtgcgaagct tgcccgagag aaaagctcat cacctagtgg     1680

gagtcccggg gacccctcat cccccacctc cagcctctgc atctccccca gtgtgtcccc     1740

agggtcaccc ccctcaagtc ctagaagcag agatgctcct gctggcagtc ccccggcctc     1800

tccagggccc cagggcccca gcaccaagct gcccctgagc ctggacctgc ccagcccccg     1860

gcccttcgct ttgcctctgg gcagccctcg aatccccctc ccggcgcagc agagctcgga     1920

ggcccgtgtc atccgcgtca gcatcgacaa tgaccacggg aacctgtatc gaagcatctt     1980

gctgaccagt caggacaaag cccccagcgt ggtccggcga gccttgcaga agcacaatgt     2040

gccccagccc tgggcctgtg actatcagct ctttcaagtc cttcctgggg accgggtgct     2100

cctgattcct gacaatgcca acgtcttcta tgccatgagt ccagtcgccc ccagagactt     2160

catgctgcgg cggaaagagg ggacccggaa cactctgtct gtctccccaa gctgaggcag     2220

ccctgtcctc tccacaagac acaagtccca caggcaagct tgcgactctt ctcctggaaa     2280

gctgccatcc cccagtagag gccactgtgc tgtgtatccc aggaccacca cccaactgta     2340

gcccattgga ccccatctct ttttctgact ctgttggtac tagatccata ttccaaagac     2400

atcagcccat gggtggctgg tggagagctc aatcccataa atgtagaaag aggtggggca     2460

tggatacgtc aaatccctcc ccagagaaat cttataaatg ttagagacgc atcagaagtg     2520

acagatgcgg atgaaaatag tgaccagagt tatgaaacag gaaaaaaaaa a              2571


<210>  839
<211>  716
<212>  PRT
<213>  Homo Sapiens

<400>  839

Met Glu Arg Thr Ala Gly Lys Glu Leu Ala Leu Ala Pro Leu Gln Asp 
1               5                   10                  15      


Trp Gly Glu Glu Thr Glu Asp Gly Ala Val Tyr Ser Val Ser Leu Arg 
            20                  25                  30          


Arg Gln Arg Ser Gln Arg Arg Ser Pro Ala Glu Gly Pro Gly Gly Ser 
        35                  40                  45              


Gln Ala Pro Ser Pro Ile Ala Asn Thr Phe Leu His Tyr Arg Thr Ser 
    50                  55                  60                  


Lys Val Arg Val Leu Arg Ala Ala Arg Leu Glu Arg Leu Val Gly Glu 
65                  70                  75                  80  


Leu Val Phe Gly Asp Arg Glu Gln Asp Pro Ser Phe Met Pro Ala Phe 
                85                  90                  95      


Leu Ala Thr Tyr Arg Thr Phe Val Pro Thr Ala Cys Leu Leu Gly Phe 
            100                 105                 110         


Leu Leu Pro Pro Met Pro Pro Pro Pro Pro Pro Gly Val Glu Ile Lys 
        115                 120                 125             


Lys Thr Ala Val Gln Asp Leu Ser Phe Asn Lys Asn Leu Arg Ala Val 
    130                 135                 140                 


Val Ser Val Leu Gly Ser Trp Leu Gln Asp His Pro Gln Asp Phe Arg 
145                 150                 155                 160 


Asp Pro Pro Ala His Ser Asp Leu Gly Ser Val Arg Thr Phe Leu Gly 
                165                 170                 175     


Trp Ala Ala Pro Gly Ser Ala Glu Ala Gln Lys Ala Glu Lys Leu Leu 
            180                 185                 190         


Glu Asp Phe Leu Glu Glu Ala Glu Arg Glu Gln Glu Glu Glu Pro Pro 
        195                 200                 205             


Gln Val Trp Thr Gly Pro Pro Arg Val Ala Gln Thr Ser Asp Pro Asp 
    210                 215                 220                 


Ser Ser Glu Ala Cys Ala Glu Glu Glu Glu Gly Leu Met Pro Gln Gly 
225                 230                 235                 240 


Pro Gln Leu Leu Asp Phe Ser Val Asp Glu Val Ala Glu Gln Leu Thr 
                245                 250                 255     


Leu Ile Asp Leu Glu Leu Phe Ser Lys Val Arg Leu Tyr Glu Cys Leu 
            260                 265                 270         


Gly Ser Val Trp Ser Gln Arg Asp Arg Pro Gly Ala Ala Gly Ala Ser 
        275                 280                 285             


Pro Thr Val Arg Ala Thr Val Ala Gln Phe Asn Thr Val Thr Gly Cys 
    290                 295                 300                 


Val Leu Gly Ser Val Leu Gly Ala Pro Gly Leu Ala Ala Pro Gln Arg 
305                 310                 315                 320 


Ala Gln Arg Leu Glu Lys Trp Ile Arg Ile Ala Gln Arg Cys Arg Glu 
                325                 330                 335     


Leu Arg Asn Phe Ser Ser Leu Arg Ala Ile Leu Ser Ala Leu Gln Ser 
            340                 345                 350         


Asn Pro Ile Tyr Arg Leu Lys Arg Ser Trp Gly Ala Val Ser Arg Glu 
        355                 360                 365             


Pro Leu Ser Thr Phe Arg Lys Leu Ser Gln Ile Phe Ser Asp Glu Asn 
    370                 375                 380                 


Asn His Leu Ser Ser Arg Glu Ile Leu Phe Gln Glu Glu Ala Thr Glu 
385                 390                 395                 400 


Gly Ser Gln Glu Glu Asp Asn Thr Pro Gly Ser Leu Pro Ser Lys Pro 
                405                 410                 415     


Pro Pro Gly Pro Val Pro Tyr Leu Gly Thr Phe Leu Thr Asp Leu Val 
            420                 425                 430         


Met Leu Asp Thr Ala Leu Pro Asp Met Leu Glu Gly Asp Leu Ile Asn 
        435                 440                 445             


Phe Glu Lys Arg Arg Lys Glu Trp Glu Ile Leu Ala Arg Ile Gln Gln 
    450                 455                 460                 


Leu Gln Arg Arg Cys Gln Ser Tyr Thr Leu Ser Pro His Pro Pro Ile 
465                 470                 475                 480 


Leu Ala Ala Leu His Ala Gln Asn Gln Leu Thr Glu Glu Gln Ser Tyr 
                485                 490                 495     


Arg Leu Ser Arg Val Ile Glu Pro Pro Ala Ala Ser Cys Pro Ser Ser 
            500                 505                 510         


Pro Arg Ile Arg Arg Arg Ile Ser Leu Thr Lys Arg Leu Ser Ala Lys 
        515                 520                 525             


Leu Ala Arg Glu Lys Ser Ser Ser Pro Ser Gly Ser Pro Gly Asp Pro 
    530                 535                 540                 


Ser Ser Pro Thr Ser Ser Leu Cys Ile Ser Pro Ser Val Ser Pro Gly 
545                 550                 555                 560 


Ser Pro Pro Ser Ser Pro Arg Ser Arg Asp Ala Pro Ala Gly Ser Pro 
                565                 570                 575     


Pro Ala Ser Pro Gly Pro Gln Gly Pro Ser Thr Lys Leu Pro Leu Ser 
            580                 585                 590         


Leu Asp Leu Pro Ser Pro Arg Pro Phe Ala Leu Pro Leu Gly Ser Pro 
        595                 600                 605             


Arg Ile Pro Leu Pro Ala Gln Gln Ser Ser Glu Ala Arg Val Ile Arg 
    610                 615                 620                 


Val Ser Ile Asp Asn Asp His Gly Asn Leu Tyr Arg Ser Ile Leu Leu 
625                 630                 635                 640 


Thr Ser Gln Asp Lys Ala Pro Ser Val Val Arg Arg Ala Leu Gln Lys 
                645                 650                 655     


His Asn Val Pro Gln Pro Trp Ala Cys Asp Tyr Gln Leu Phe Gln Val 
            660                 665                 670         


Leu Pro Gly Asp Arg Val Leu Leu Ile Pro Asp Asn Ala Asn Val Phe 
        675                 680                 685             


Tyr Ala Met Ser Pro Val Ala Pro Arg Asp Phe Met Leu Arg Arg Lys 
    690                 695                 700                 


Glu Gly Thr Arg Asn Thr Leu Ser Val Ser Pro Ser 
705                 710                 715     


<210>  840
<211>  15245
<212>  DNA
<213>  Homo Sapiens

<400>  840
cgctccgccc gcccggccgc cccgagcccc gagccccgag ccccccgcgc cgggcccggg       60

cggcagcggc ggcggcggcg gcggcggcgc gcccggcccc ctcccccggc gccggccacg      120

ggaggcggtg atgcgggcgc gggcggcctc ggctgcgccg agagcggaga cacaggctca      180

agatggcaga ttccgactga ggctgggggg gccgagctcg cgcgccgctt tcccgtcccc      240

gttgccatga accgcggaca ccccggcccc gatggccccc gtgtacgaag gtatggcctc      300

acatgtgcaa gttttctccc ctcacaccct tcaatcaagt gccttctgta gtgtgaagaa      360

actgaaaata gagccgagtt ccaactggga catgactggg tacggctccc acagcaaagt      420

gtatagccag agcaagaaca tccccctgtc gcagccagcc accacaaccg tcagcacctc      480

cttgccggtc ccaaacccaa gcctacctta cgagcagacc atcgtcttcc caggaagcac      540

cgggcacatc gtggtcacct cagcaagcag cacttctgtc accgggcaag tcctcggcgg      600

accacacaac ctaatgcgtc gaagcactgt gagcctcctt gatacctacc aaaaatgtgg      660

actcaagcgt aagagcgagg agatcgagaa cacaagcagc gtgcagatca tcgaggagca      720

tccacccatg attcagaata atgcaagcgg ggccactgtc gccactgcca ccacgtctac      780

tgccacctcc aaaaacagcg gctccaacag cgagggcgac tatcagctgg tgcagcatga      840

ggtgctgtgc tccatgacca acacctacga ggtcttagag ttcttgggcc gagggacgtt      900

tgggcaagtg gtcaagtgct ggaaacgggg caccaatgag atcgtagcca tcaagatcct      960

gaagaaccac ccatcctatg cccgacaagg tcagattgaa gtgagcatcc tggcccggtt     1020

gagcacggag agtgccgatg actataactt cgtccgggcc tacgaatgct tccagcacaa     1080

gaaccacacg tgcttggtct tcgagatgtt ggagcagaac ctctatgact ttctgaagca     1140

aaacaagttt agccccttgc ccctcaaata cattcgccca gttctccagc aggtagccac     1200

agccctgatg aaactcaaaa gcctaggtct tatccacgct gacctcaaac cagaaaacat     1260

catgctggtg gatccatcta gacaaccata cagagtcaag gtcatcgact ttggttcagc     1320

cagccacgtc tccaaggctg tgtgctccac ctacttgcag tccagatatt acagggcccc     1380

tgagatcatc cttggtttac cattttgtga ggcaattgac atgtggtccc tgggctgtgt     1440

tattgcagaa ttgttcctgg gttggccgtt atatccagga gcttcggagt atgatcagat     1500

tcggtatatt tcacaaacac agggtttgcc tgctgaatat ttattaagcg ccgggacaaa     1560

gacaactagg tttttcaacc gtgacacgga ctcaccatat cctttgtgga gactgaagac     1620

accagatgac catgaagcag agacagggat taagtcaaaa gaagcaagaa agtacatttt     1680

caactgttta gatgatatgg cccaggtgaa catgacgaca gatttggaag ggagcgacat     1740

gttggtagaa aaggctgacc ggcgggagtt cattgacctg ttgaagaaga tgctgaccat     1800

tgatgctgac aagagaatca ctccaatcga aaccctgaac catccctttg tcaccatgac     1860

acacttactc gattttcccc acagcacaca cgtcaaatca tgtttccaga acatggagat     1920

ctgcaagcgt cgggtgaata tgtatgacac ggtgaaccag agcaaaaccc ctttcatcac     1980

gcacgtggcc cccagcacgt ccaccaacct gaccatgacc tttaacaacc agctgaccac     2040

tgtccacaac caggctccct cctctaccag tgccactatt tccttagcca atcccgaagt     2100

ctccatacta aactacccat ctacactcta ccagccctca gcggcatcca tggctgcagt     2160

ggcccagcgg agcatgcccc tgcagacagg aacagcccag atttgtgccc ggcctgaccc     2220

gttccagcaa gctctcatcg tgtgtccccc cggcttccaa ggcttgcagg cctctccctc     2280

taagcacgct ggctactcgg tgcgaatgga aaatgcagtt cccatcgtca ctcaagcccc     2340

aggagctcag cctcttcaga tccaaccagg tctgcttgcc cagcaggctt ggccaagtgg     2400

gacccagcag atcctgcttc ccccagcatg gcagcaactg actggagtgg ccacccacac     2460

atcagtgcag catgccaccg tgattcccga gaccatggca ggcacccagc agctggcgga     2520

ctggagaaat acgcatgctc acggaagcca ttataatccc atcatgcagc agcctgcact     2580

attgaccggt catgtgaccc ttccagcagc acagccctta aatgtgggtg tggcccacgt     2640

gatgcggcag cagccaacca gcaccacctc ctcccggaag agtaagcagc accagtcatc     2700

tgtgagaaat gtctccacct gtgaggtgtc ctcctctcag gccatcagct ccccacagcg     2760

atccaagcgt gtcaaggaga acacacctcc ccgctgtgcc atggtgcaca gtagcccggc     2820

ctgcagcacc tcggtcacct gtgggtgggg cgacgtggcc tccagcacca cccgggaacg     2880

gcagcggcag acaattgtca ttcccgacac tcccagcccc acggtcagcg tcatcaccat     2940

cagcagtgac acggacgagg aggaggaaca gaaacacgcc cccaccagca ctgtctccaa     3000

gcaaagaaaa aacgtcatca gctgtgtcac agtccacgac tccccctact ccgactcctc     3060

cagcaacacc agcccctact ccgtgcagca gcgtgctggg cacaacaatg ccaatgcctt     3120

tgacaccaag gggagcctgg agaatcactg cacggggaac ccccgaacca tcatcgtgcc     3180

acccctgaaa acccaggcca gcgaagtatt ggtggagtgt gatagcctgg tgccagtcaa     3240

caccagtcac cactcgtcct cctacaagtc caagtcctcc agcaacgtga cctccaccag     3300

cggtcactct tcagggagct catctggagc catcacctac cggcagcagc ggccgggccc     3360

ccacttccag cagcagcagc cactcaatct cagccaggct cagcagcaca tcaccacgga     3420

ccgcactggg agccaccgaa ggcagcaggc ctacatcact cccaccatgg cccaggctcc     3480

gtactccttc ccgcacaaca gccccagcca cggcactgtg cacccgcatc tggctgcagc     3540

cgctgccgct gcccacctcc ccacccagcc ccacctctac acctacactg cgccggcggc     3600

cctgggctcc accggcaccg tggcccacct ggtggcctcg caaggctctg cgcgccacac     3660

cgtgcagcac actgcctacc cagccagcat cgtccaccag gtccccgtga gcatgggccc     3720

ccgggtcctg ccctcgccca ccatccaccc gagtcagtat ccagcccaat ttgcccacca     3780

gacctacatc agcgcctcgc cagcctccac cgtctacact ggatacccac tgagccccgc     3840

caaggtcaac cagtaccctt acatataaac actggagggg agggagggag ggagggaggg     3900

agagaatggc ccgagggagg agggagagaa ggagggaggc gctcctggga ccgtgggcgc     3960

tggcctttta tactgaagat gccgcacaca aacaatgcaa acggggcagg ggcggggggg     4020

gggggggggg cagagggcag ggggacgggt cgggacacca gtgaaacttg aaccgggaag     4080

tgggaggacg tagagcagag aagagaacat ttttaaaagg aagggattaa agagggtggg     4140

aaatctatgg tttttatttt aaaaaagaaa aaggaaaaaa aaaaagtcaa taacaaaaaa     4200

cccagctcaa gaacccattc tacgccaaac tggaaaggag aagagagcaa caggaagatt     4260

ccagaaacgg ggggccccag tttttgaaga actttatgaa cttttcaaag attattttca     4320

tatggcagca agtgatacgg aagactgctg tcagggacac ctgatatgga aatcaaatag     4380

atttttaatt aattgaacat aagatttagg gatttttcca gaactcgaaa gggtcaacag     4440

ccctccagaa tgtcgggctg cagcctgagg aggctgatgt ttggagctgg tgtgggattg     4500

gcgaagccca gtccgggctc cctagtcagg aaagacgggg gacggccagg ctgctggaag     4560

gcccccgggg gcgcggggcg agttttcttt ttctgagcac tctggataaa tccctaagca     4620

acgttgtttc tcaaatgtca ttaataatgt gtgttgcaaa ctttaggttt ttttcttttc     4680

tgaaaatgta ttttctcttt gaatccaccc ctagtcgcgt agcgtagggc tagcggtcgt     4740

cacagacacc ctagtagaat gtagcactca gcacccttgt ctcctacctt gtgttcaact     4800

ccaatgatac caatagaata ttcctcaatg taattgcaca aaaaaaagcg atataacata     4860

ggcatgtaac caatgtggcg gtgcaggtgt gcgggtgagc gagcacgtgt gggtgtgcac     4920

gcgccgccct ccccgcgtgg ccctcggcgc cgccacccta gctggcgcag tcttgacact     4980

gcatccttcc ctcctagtgc cttaccgagc gacagacgcg gcgtgagggt ttacttccac     5040

tggtactcca agaaactgag gctagtcaga cacaatctca gctcttctgt tgtgctgttg     5100

taacagttta cgctggcctt ttttttttct ttttcttttt ctttttaaaa tgttaatgcc     5160

cgttgtcttt cctgggctgt ttgctagcgg aaggatgcca gggaagccag caggagctag     5220

gagagagtcc gtggatctcg aaagaaatat gggagacaga tgcccggcgg gtgcgtctgg     5280

agatggggac ggcgggagtt gagttgtggc agtagttgag ttgtaatttg tgggcggagg     5340

cccagagaga ctccccaccc ttcacccctg ccccactctg tccccagttc cgccatttgt     5400

gaggccagag gtttccggac tgttggcctc gccaggcagc cgtctcccgc cccaggcggc     5460

atcccccagt ccctcccgcc tccacgagag cctggagctc tcagcctcgc ccggggctcc     5520

actctctcct ccggctccct gggctgtttt gctctaacga tcttgccaga tccctccctc     5580

tgtagacaac caccaacctc tgtttgctgt tgaattctct cctcacatta cccaggtctg     5640

ctcaagacat gattttggtt ttggtttctg agggttctag tgggcagaag gttggaggga     5700

cacttatgag ggtggccggg ggtctgacgc tgcactttgg aaaaactcac acagttgaat     5760

ttccaaagaa atctgccctt tgccctcttt gcacctttga tacattctgg aagttttctc     5820

aggctttgga cacttctggg gatggaggtg tggagaagtg gggagttccc tctcttcata     5880

gtaaataact ctgaaatatg tgaatgtgaa tggcaggaga atctggccaa ggatggggcc     5940

gaaaagggtg gttctaattg tttgcttctg atgttgagtc tttagctgac cccacaggca     6000

ggtttccaag gtgcaaagag atctttcccg agtcagcggc cccatcctca tcctccctcc     6060

ctttacttcc tcactgtgca gtctccctca aggatctact gtgaaaggtg tgtttgtagt     6120

gatatccaac ctaactcagt aacgaagtcg ttacttagct cttagctgtg aaataactct     6180

ggaaacttcc ccaccccaac cataaattct tacttataaa gaaacaggtc cccaaactgg     6240

aaacagctta gtccaggcct cagcgagaag gaaggacacc atgactgctc catgctgggc     6300

acagccgggc agtcttgcca agtgcctgct ggaggctgtg ccggcaagag gcctgcagca     6360

aggagattcc cttccctcgg gccattatca atactgtctt tatctggagg tggggaagcg     6420

cagccctctg agacagcagg acaatggtca gttcagagag ggtgagggca gcaaacgctt     6480

cagaggacac agaagccaga ggaccccccc ccgccccaca gctgggtcag cctggaaaat     6540

ccatctatta gggacttttt ggcagccaga tggcagcaat agcccattag gtctcatccc     6600

gagttccaag tcttggctgc aaatgagcct cagttcgcct tactggagag cacccccaga     6660

ttcctgggca cagttcattt ccagcccttt ctagatctga tcttttaggg ggaaagacag     6720

cttaaaatgt tcttttcatt ttaaagaaaa ttattctgtc tgcttaagtt ggaggctact     6780

tactctttca cctgacattt tctttccttt tattcttcca gatcaggaat gaaatttcca     6840

tgctgctcat aaagataata ttattgtact aattattttt attaccattg taattatgat     6900

cattatgttg atattttagt cagggtttta aatgcacatt tattccaagt atctttgtgt     6960

tttctcttta atatttaaac ttattctctc tgtgagtata taagtagact ggagggacat     7020

ccagatgtcc agttttgtca ggcaaaaaaa aaaaggaaag acttaggaag taggaaaatt     7080

gtttctgtca tctctatccc aacaagagac gtcaagaaag atccaccaca gaacaaaagt     7140

ttaaagaaga atcaaagcct tgattgggct tctgacaaca tggtcaccat caaggttgtc     7200

attttctaga tcccagaggc ctgggatgcg acgtcaggtg gcatctcatg ggctcgggga     7260

atgtcgagtc actgactgtc cagcccttag ccagcttctc tcccacatcc tcagagctct     7320

cctgtgcttc tgaaatctgt taactaaatc tttggcttgc ctctggtatt taagcaagaa     7380

aattccctcc cagaggtgac cccatccgct tccccacaat ccatcctttt gccatcggcg     7440

cacctggggc gtggcttagg ttcttcaatg cagggacatt tgccccctcc cagaagctgc     7500

tgggcacagt gaggtggcgt aagagtgact ggcaggtggt accttcccca ggaaatttca     7560

ccacaccacc cagttcctca gcctgccccc tccccctgtg atgcatgccc ccagcaccca     7620

attctagcca gctggaagtg ggtggaggga cagcaggagg ccagagaaac cctgaacaaa     7680

gctgggcggc tgctcaggca tcacaggctg caccccctct gaaagcatcc ccactgggct     7740

ccggccacat cttcagtgca ctgtgctgtg tgcgctgggt gctcacacgc tgtccccaga     7800

cccacaaagt gctaggcccc agttgaagaa aggggtgaaa tagccagctt caccgaaggg     7860

aagggaaggg aagtattggg cgatgccagc cccacagacg ctcagcaaac attagtgcac     7920

attctcctag tcctcaccca atggcctcct ctacccccat gcatggagct gccacatcag     7980

aagccccaag agaagctccc tgcaggagag gccagctccc tggatgccca attgcatacc     8040

tggccgaatc tgccattgag tcaccttagc aaataggctg ctgtcactag gaccaagctc     8100

tcaagcagag ggatgccaac ctagtcctta cttagcccac gaatcatcta gagcatcctc     8160

tagtcttttg tgggctccct ccttcccatt tgaagagaca ttgttcagag gaagagggga     8220

agatttgaaa tgtcaggtca cggaggagtg tttaactgga gcctggtgaa ccgcagggca     8280

atttgcttct gctcactggg ttctgactgg cccgtctgga cgtgggcccc catgtctctg     8340

tgcttagggc ctcttcatga tgttttggat gtttccaagg gaagtgggtg agcagatcaa     8400

ggggtgggag agtcgaggct tgatgccagt taatactgtg aagtggagcg tgcggtcagt     8460

ggaattcaga ggaaaaagaa gggttggagc aaagcggcat tcatctcctg gactgttagc     8520

ctttctagtc ttcctggtgg ctgaggtgtt cacgggctgg gggagccagc tgacctttgt     8580

cctcttcaac ctagaagact cagcccgccc agacaccaac gtgtgagacg gatggacatc     8640

aggaagggaa ggggagatta gcccaactgc tgacagaacg atttcccttg gttggacctt     8700

gggaatggca aacactcata ttggaacaag cttggggtgg aagatttagg ccgtgtgagc     8760

atgtgtgagt gagtggaaca aactttcttg gaaactggag ggaggagatg aggaggcttc     8820

gggaagtatt actgatggct catggttgag agagcgacgt ggggacccag ctcgccccag     8880

cttttgtccc aggttctctt tgtctgatgc tgagggcagg gtggggtgtg ggaccaccac     8940

tcttgttggc ctgtcaagta gaccctagga cagaaaatgg aaagaaggaa atggctcggt     9000

gctctcaact agcagagaga attgaggaga ggtaagggtt ccttctgcag gccagcctgg     9060

gactccacag cgccagcagg agtgacttgg ccacaagaca ttccagcccc agggactttg     9120

caggcttcat tccctgtctg tgtcttttcc ttctggtgtg ttttacagac ttctgatggg     9180

gaagcttcaa acttgagcag gccagagatg tccttaccaa attggaaagg aaggtgaaac     9240

tgttcctttc tttagccaaa gaacccttct caaagacgcc tccagaaatg gacaaaatgg     9300

ccttcccttc gttcctttcc aggcaataat gacatcatta gtgatgcaat tctatttgtc     9360

tttctctttc ctctctgtcc ttttttttaa aaaaaaaaaa tgcatttatt tcaaaactgt     9420

gctattcttt taagaggagt ggaggtgacc ccttcgatgc tgctgctatc gggagacaag     9480

gtgccatacc aatacgtggg cttgactaat cccaggccac catgggagag agcaaagcag     9540

ggctgccagg agttcagttg catcaagggc gtagagcacg cgggggctgg gctcggaata     9600

gcagtacttt tccactttga tgccttagaa ctctcacttc tcatctccac agaccagact     9660

cagtaaaatc tcaggccact agagaatgga aggcggtgaa acaggattta aatgcaaaaa     9720

aaacctattg gaggcttttg gcaccgtggc tcactagagg gacccagcat agtagaggtt     9780

tctcttgttg cagcttctga aaagttcaaa aaagaactcc aggccgttct tccctcaaac     9840

ccagtgagag tttgcagaga agtgccccct gcagggctcc cgtcccagaa caccagcacc     9900

agagagggtc ttcccgatgc cccccgctgg acttgcccaa gcctctggga gcccctcatc     9960

tcagatccct gtgttgaaca tgacactgac tgtcccttat ttgttaaaat ttgcaatatc    10020

tctcaagtaa ataatagcca acatttgttg aatgctttca tgactcccgg gctaaggcct    10080

ttatgagcgt tgtctcaagg ggccccaaca gccatcccac agggaggggg ataacagccc    10140

ccatttatag ataagggagc tgaccggatg ctctgagaag tggcaggtgt tgaaggaagg    10200

ataaagcagt gatgggccag aatccccaag gttccctttt ttgttcatca ggcccttcct    10260

gagatgtgat ttttaatctt ttaacttttt ttaattaata gcaatgcgtg gcctcatatt    10320

tctatgaacc atttagtgat actcccgctt cctgcatgcc acacactgtg ctgggaattg    10380

ctcatgggtt gtcctgtttc atcttctccg tagccctgtg agatcggcaa tattagtccc    10440

cctacagcca aggaaactgc ccagagccac acaactcttg aggggcgagg agggcttgaa    10500

cctgagtctg cccagctcca gaactgagct tgcagccatt agccacagct gtctcctgca    10560

tgtctgagca aagaaaggcc tttacacagc atcaccctgt gccatcccat gcaccgtggg    10620

actcagctaa aggactgtgc aaagaggggg ctcctgagtt ggatttaggc aaaaggggca    10680

gaattcgttt gatttttaga gaaaatctct ggagagtttc ttttgattca tagaattcct    10740

tttagatttc tttccagcat accaactagc tttagtagtg ctgctacaac cagctcttat    10800

aagtaagagt gaaaaagtat tcttttcttc tttaaaaaat aagtttttct tgcttatagt    10860

taattctaga aaggcaatac taaaggtata tatttttttc aaaatgctat tttttactgc    10920

acttgataat tatcctgaca gctctgatct ctgtaataga ttcactcttc agctctgggc    10980

agaaccagag gcagggttca caccaaattt gtaaatacca tatgtgggtc tggtgtccag    11040

gaactttttt ctttctgtta aaaaaaagaa aaaaaaaaga aaaaaaaaaa gaagtagagg    11100

tggaagaaag acaagactta gaggaacaaa agaatgtttt cttttgagat actcttctca    11160

aagaaatagc aacaattgta taaacaggaa aaccagccag ctttcatgat aaaaggaagg    11220

cgtgtctctt gccctggtat gagattaaca gaaatacaga tgcattttta ttttgattga    11280

aagatggtga gaatgtagaa atgcttagga ctagattttt aattttttaa aataactatt    11340

atcatttatt atgaaatatt tgttcagttg ttttgagtgg gtttcttgtt ccttttttca    11400

tttaaaacct tctttgttga ctggctccag gcttgtttgc ctaaattctt aggtagttta    11460

cacaagttct agaatctttt agaactttaa ctccattgga agcaaaccta actaatcgga    11520

gtttgagatc ctggttggtt tcaataggta ttctggaatt ctggcagaac acctaaagat    11580

tttttttttt tttagaaggt tttagataca ttatcttaca caaactgtga cctaatggca    11640

ataattacct caaatgtggg cattcatcct ggttttagcc ttttttgaaa tcatgtagcc    11700

agcttgatct tggaatttaa agactatgaa ttctctgtgg gctgaaaata atgattactt    11760

catacccccg gtcatcgttg cttaagtgaa ttctgaaaat agctcatctt tacaacaaaa    11820

attaaaccaa ggaagagatt attctttgtg tgttgtactc aaatgcgatg ttcaaatgca    11880

catgttaagt atatatgttt ttagctactg taaaatgctg ttagccttct aagctatcaa    11940

aacagtcaca ttttaaatga gtaaactaaa caattgactg tggatactta agcatatttc    12000

tggctacgtt ttatagttaa agtgttttat agtttacatt tagactggta ctttttaaag    12060

aaaagttctg tttataactg acatccgcaa accccagtga atgcctctta gttggaggtt    12120

gtgtctcccc caaggcaagt gtgttgtccc agactcttct gtagtccagc atgcgcactt    12180

ccctctggat tattactttc cacgtgaact caagagaaca tgaaaggcaa tccagatgga    12240

gggaaaaggt gtgagtccgc agcccgggcc agatgcgaag gtctcatgcg tgtcgtctaa    12300

acacttgtct tcaaggcctt ctctctgaca tcttggaaga gtcattgaga acagataacc    12360

tggttcattg atttttgtct tgatttgaat atttaactta ttaatagatc cactgatttc    12420

caggcaccag gcagtagaag agactgggat tcaggtgacc atgaaggcac agctgctact    12480

tctgggccgg gggtgatatt ttgatcagcg ttttgtaggg gaggaccata tacccctatt    12540

cccatggtcg ctggctgggt tttccatata tctgctgtca tttattcgtt ttccccttaa    12600

aagcaaaatc aatgtaaaag gctatgttta cgttttactc attgtccagc ttagactcaa    12660

agtctagttc ggtgggaggg ggaccttagc atcctctcag agatggtcag ggctgagcag    12720

gaggaggcag agacagaggg gcagctcagc ctggtccatt gagacccact ctaaacagac    12780

atcatatttg gaacaagaag atgcttcgag acaggaatgg gccccactgt catgcagaaa    12840

cagactgggg gaatggcagt ttccctgagt cttggtttct tttatgtttt ctcttgtgcc    12900

accaccaaac tgcagaggac ctgctgtgac ctaaagggca ttcctttagc agataagacc    12960

ttgaaaactg caaaacacct gggaccaggg agcttttaaa aaatacaaaa aaataccaca    13020

tttgcttttt ccctgtgaac tgtattgaca gcgtgttctt aggacagtct tttggtggaa    13080

atgttactgt aaaatagttt tcatctcacc cctcctaatc atactcccac tttcctgttt    13140

gtgtggtggt gttgctgttt tttcctttac atgaattaac caaatgaatt ttgtgtcatt    13200

gtttttgggg cttatatttt taaaacatag aaattgcctt ttgttcattt gaaaagtaag    13260

tatgttgtat ctgaaaaagg gctctgcctc tgctctccct cgcttccttg taaccaatct    13320

ccaaacgaat ctctcctggc accgccccct tccttatata gggtcactgt ccccggggcc    13380

acctctgcct ccaccctgct gtcaccactg ccctgggcca aggcacccag gactcccaga    13440

aagcgcgaga gccagcaaga aggccccact cagccttgag actggtggtc acacctccct    13500

gtcagagtcg cctgctgggc tgaaggggca atggattgtc attgttgaaa ttgtttggct    13560

caggttataa ggaggaactt gggaagtaga aagtgacttg accatgtgca tccttggtag    13620

cttcctgtaa ctaacaaatg gaacagagag cacacccccg ccccgcccca ccccaagcag    13680

atgttcccgt cagcgctgcc ctgagtcagt cggtcccccg tttctgctct cctccctttt    13740

gtgttcctgc tcacttcaag cttcttccat ggactttcca gggcacagtc atctctagcc    13800

cccaaatcat ctcttcatcc tctgtgtgtg cattttttta accaaatgaa atagacaaga    13860

aagtcatact ttggggcagc agaatttcta atttagtaga atcactgtat agagatagat    13920

gttgatatat atgtttgtgt atatatatca aaccaaattg gataggagaa gtatagcttt    13980

acagatgagg agaaggagct ctttagaggt cggagtcaag actggtgtct tggacgtgca    14040

tgggctgtgt cccaggccac tccgcacaca tggggctgag gcgtggcgcc gggcccttgt    14100

catccacctc accacggcag agccagcagg ccctgtaggg tgctgctgct gtctcactgg    14160

gtcccagctt caagcgcatc agtgggtgac gggggcaaca aatcagagtg actggaagtt    14220

tccatcccgt tttgctttga ccacgtgtac tgagctgcag cctctgatac tctgtcacgt    14280

ttccaaaaat ggtatccatt aggatagaaa gagaatggat ctgcagaaat gtttaccttt    14340

caactgctca tgaattcagg acactggata gaaagactca ctccccaaaa tgagaacagg    14400

gaagaggaga cccggcgaca ctaagtcacc aggtccaagg aacgtggctc cctccccagg    14460

gtcatctcac ctagatcttt ctctcccagg tcatctcagc tcaatctcaa taaccctatg    14520

aaagccctgg tctgttgtgt tccttcaccg tacggtttct gtaataaaaa gtgttaatcc    14580

atgttaatct gtgtgaaaat tattgcgtgc aacagtattt tctcgtgtac ctctttttcc    14640

tatgtgaatt gtccctcttt tttatttata aatgtctact tttgtttttt taaagacaaa    14700

ccaatgtgtt gtagacctat atgtaaccta ttccttagtc tcatattata ggtatgttat    14760

aagaatggat attttacttg gctttagaat gttttacaag aaaactaatt cttaactgat    14820

caagtccttg ctactaaaat gcttgtgttt ttcatcatga cgtcgtgtgc ttctaaatta    14880

atcattttcg ttgtagaaaa atggagtgaa tttatattag tcttggaaac taataatagc    14940

attgtaaatt tatgagatga ttttaacaga aaaaatatag aagaatatag ttattttaat    15000

tgtaatatta ctaactgtag ggtgagaaaa aggggggggg gtcccattgt ggtgaactat    15060

gttatagctt gttactcata gtttcttttt gatcattttt tcggtctccg aggtgaaatg    15120

acttattaat taaaatttgt aaactcacat atgcatattg tatatgtgta gaaatgtaat    15180

cacactttgt cttggaatta cattaaactg tttgaaatca ctgtaaaaaa aaaaaaaaaa    15240

aaaaa                                                                15245


<210>  841
<211>  1198
<212>  PRT
<213>  Homo Sapiens

<400>  841

Met Ala Pro Val Tyr Glu Gly Met Ala Ser His Val Gln Val Phe Ser 
1               5                   10                  15      


Pro His Thr Leu Gln Ser Ser Ala Phe Cys Ser Val Lys Lys Leu Lys 
            20                  25                  30          


Ile Glu Pro Ser Ser Asn Trp Asp Met Thr Gly Tyr Gly Ser His Ser 
        35                  40                  45              


Lys Val Tyr Ser Gln Ser Lys Asn Ile Pro Leu Ser Gln Pro Ala Thr 
    50                  55                  60                  


Thr Thr Val Ser Thr Ser Leu Pro Val Pro Asn Pro Ser Leu Pro Tyr 
65                  70                  75                  80  


Glu Gln Thr Ile Val Phe Pro Gly Ser Thr Gly His Ile Val Val Thr 
                85                  90                  95      


Ser Ala Ser Ser Thr Ser Val Thr Gly Gln Val Leu Gly Gly Pro His 
            100                 105                 110         


Asn Leu Met Arg Arg Ser Thr Val Ser Leu Leu Asp Thr Tyr Gln Lys 
        115                 120                 125             


Cys Gly Leu Lys Arg Lys Ser Glu Glu Ile Glu Asn Thr Ser Ser Val 
    130                 135                 140                 


Gln Ile Ile Glu Glu His Pro Pro Met Ile Gln Asn Asn Ala Ser Gly 
145                 150                 155                 160 


Ala Thr Val Ala Thr Ala Thr Thr Ser Thr Ala Thr Ser Lys Asn Ser 
                165                 170                 175     


Gly Ser Asn Ser Glu Gly Asp Tyr Gln Leu Val Gln His Glu Val Leu 
            180                 185                 190         


Cys Ser Met Thr Asn Thr Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly 
        195                 200                 205             


Thr Phe Gly Gln Val Val Lys Cys Trp Lys Arg Gly Thr Asn Glu Ile 
    210                 215                 220                 


Val Ala Ile Lys Ile Leu Lys Asn His Pro Ser Tyr Ala Arg Gln Gly 
225                 230                 235                 240 


Gln Ile Glu Val Ser Ile Leu Ala Arg Leu Ser Thr Glu Ser Ala Asp 
                245                 250                 255     


Asp Tyr Asn Phe Val Arg Ala Tyr Glu Cys Phe Gln His Lys Asn His 
            260                 265                 270         


Thr Cys Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu 
        275                 280                 285             


Lys Gln Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Val 
    290                 295                 300                 


Leu Gln Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu 
305                 310                 315                 320 


Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Ser 
                325                 330                 335     


Arg Gln Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His 
            340                 345                 350         


Val Ser Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg 
        355                 360                 365             


Ala Pro Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met 
    370                 375                 380                 


Trp Ser Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu 
385                 390                 395                 400 


Tyr Pro Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr 
                405                 410                 415     


Gln Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr 
            420                 425                 430         


Arg Phe Phe Asn Arg Asp Thr Asp Ser Pro Tyr Pro Leu Trp Arg Leu 
        435                 440                 445             


Lys Thr Pro Asp Asp His Glu Ala Glu Thr Gly Ile Lys Ser Lys Glu 
    450                 455                 460                 


Ala Arg Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn 
465                 470                 475                 480 


Met Thr Thr Asp Leu Glu Gly Ser Asp Met Leu Val Glu Lys Ala Asp 
                485                 490                 495     


Arg Arg Glu Phe Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala 
            500                 505                 510         


Asp Lys Arg Ile Thr Pro Ile Glu Thr Leu Asn His Pro Phe Val Thr 
        515                 520                 525             


Met Thr His Leu Leu Asp Phe Pro His Ser Thr His Val Lys Ser Cys 
    530                 535                 540                 


Phe Gln Asn Met Glu Ile Cys Lys Arg Arg Val Asn Met Tyr Asp Thr 
545                 550                 555                 560 


Val Asn Gln Ser Lys Thr Pro Phe Ile Thr His Val Ala Pro Ser Thr 
                565                 570                 575     


Ser Thr Asn Leu Thr Met Thr Phe Asn Asn Gln Leu Thr Thr Val His 
            580                 585                 590         


Asn Gln Ala Pro Ser Ser Thr Ser Ala Thr Ile Ser Leu Ala Asn Pro 
        595                 600                 605             


Glu Val Ser Ile Leu Asn Tyr Pro Ser Thr Leu Tyr Gln Pro Ser Ala 
    610                 615                 620                 


Ala Ser Met Ala Ala Val Ala Gln Arg Ser Met Pro Leu Gln Thr Gly 
625                 630                 635                 640 


Thr Ala Gln Ile Cys Ala Arg Pro Asp Pro Phe Gln Gln Ala Leu Ile 
                645                 650                 655     


Val Cys Pro Pro Gly Phe Gln Gly Leu Gln Ala Ser Pro Ser Lys His 
            660                 665                 670         


Ala Gly Tyr Ser Val Arg Met Glu Asn Ala Val Pro Ile Val Thr Gln 
        675                 680                 685             


Ala Pro Gly Ala Gln Pro Leu Gln Ile Gln Pro Gly Leu Leu Ala Gln 
    690                 695                 700                 


Gln Ala Trp Pro Ser Gly Thr Gln Gln Ile Leu Leu Pro Pro Ala Trp 
705                 710                 715                 720 


Gln Gln Leu Thr Gly Val Ala Thr His Thr Ser Val Gln His Ala Thr 
                725                 730                 735     


Val Ile Pro Glu Thr Met Ala Gly Thr Gln Gln Leu Ala Asp Trp Arg 
            740                 745                 750         


Asn Thr His Ala His Gly Ser His Tyr Asn Pro Ile Met Gln Gln Pro 
        755                 760                 765             


Ala Leu Leu Thr Gly His Val Thr Leu Pro Ala Ala Gln Pro Leu Asn 
    770                 775                 780                 


Val Gly Val Ala His Val Met Arg Gln Gln Pro Thr Ser Thr Thr Ser 
785                 790                 795                 800 


Ser Arg Lys Ser Lys Gln His Gln Ser Ser Val Arg Asn Val Ser Thr 
                805                 810                 815     


Cys Glu Val Ser Ser Ser Gln Ala Ile Ser Ser Pro Gln Arg Ser Lys 
            820                 825                 830         


Arg Val Lys Glu Asn Thr Pro Pro Arg Cys Ala Met Val His Ser Ser 
        835                 840                 845             


Pro Ala Cys Ser Thr Ser Val Thr Cys Gly Trp Gly Asp Val Ala Ser 
    850                 855                 860                 


Ser Thr Thr Arg Glu Arg Gln Arg Gln Thr Ile Val Ile Pro Asp Thr 
865                 870                 875                 880 


Pro Ser Pro Thr Val Ser Val Ile Thr Ile Ser Ser Asp Thr Asp Glu 
                885                 890                 895     


Glu Glu Glu Gln Lys His Ala Pro Thr Ser Thr Val Ser Lys Gln Arg 
            900                 905                 910         


Lys Asn Val Ile Ser Cys Val Thr Val His Asp Ser Pro Tyr Ser Asp 
        915                 920                 925             


Ser Ser Ser Asn Thr Ser Pro Tyr Ser Val Gln Gln Arg Ala Gly His 
    930                 935                 940                 


Asn Asn Ala Asn Ala Phe Asp Thr Lys Gly Ser Leu Glu Asn His Cys 
945                 950                 955                 960 


Thr Gly Asn Pro Arg Thr Ile Ile Val Pro Pro Leu Lys Thr Gln Ala 
                965                 970                 975     


Ser Glu Val Leu Val Glu Cys Asp Ser Leu Val Pro Val Asn Thr Ser 
            980                 985                 990         


His His Ser Ser Ser Tyr Lys Ser  Lys Ser Ser Ser Asn  Val Thr Ser 
        995                 1000                 1005             


Thr Ser  Gly His Ser Ser Gly  Ser Ser Ser Gly Ala  Ile Thr Tyr 
    1010                 1015                 1020             


Arg Gln  Gln Arg Pro Gly Pro  His Phe Gln Gln Gln  Gln Pro Leu 
    1025                 1030                 1035             


Asn Leu  Ser Gln Ala Gln Gln  His Ile Thr Thr Asp  Arg Thr Gly 
    1040                 1045                 1050             


Ser His  Arg Arg Gln Gln Ala  Tyr Ile Thr Pro Thr  Met Ala Gln 
    1055                 1060                 1065             


Ala Pro  Tyr Ser Phe Pro His  Asn Ser Pro Ser His  Gly Thr Val 
    1070                 1075                 1080             


His Pro  His Leu Ala Ala Ala  Ala Ala Ala Ala His  Leu Pro Thr 
    1085                 1090                 1095             


Gln Pro  His Leu Tyr Thr Tyr  Thr Ala Pro Ala Ala  Leu Gly Ser 
    1100                 1105                 1110             


Thr Gly  Thr Val Ala His Leu  Val Ala Ser Gln Gly  Ser Ala Arg 
    1115                 1120                 1125             


His Thr  Val Gln His Thr Ala  Tyr Pro Ala Ser Ile  Val His Gln 
    1130                 1135                 1140             


Val Pro  Val Ser Met Gly Pro  Arg Val Leu Pro Ser  Pro Thr Ile 
    1145                 1150                 1155             


His Pro  Ser Gln Tyr Pro Ala  Gln Phe Ala His Gln  Thr Tyr Ile 
    1160                 1165                 1170             


Ser Ala  Ser Pro Ala Ser Thr  Val Tyr Thr Gly Tyr  Pro Leu Ser 
    1175                 1180                 1185             


Pro Ala  Lys Val Asn Gln Tyr  Pro Tyr Ile 
    1190                 1195             


<210>  842
<211>  1865
<212>  DNA
<213>  Homo Sapiens

<400>  842
ggtgtctctg gccgctgcgc tccaccccag cccgccatgg cgtcaggcgc cgcggccccg       60

gggaggtggc tcccacttta agaagtgaag ttttgcgccc ctccccctcc ctgcccacct      120

cctgcagcct cctgcgcccc gccgagctgg cggatggagc tgcgcagcgg gagcgtgggc      180

agccaggcgg tggcgcggag gatggatggg gacagccgag atggcggcgg cggcaaggac      240

gccaccgggt cggaggacta cgagaacctg ccgactagcg cctccgtgtc cacccacatg      300

acagcaggag cgatggccgg gatcctggag cactcggtca tgtacccggt ggactcggtg      360

aagacacgaa tgcagagttt gagtccagat cccaaagccc agtacacaag tatctacgga      420

gccctcaaga aaatcatgcg gaccgaaggc ttctggaggc ccttgcgagg cgtcaacgtc      480

atgatcatgg gtgcagggcc ggcccatgcc atgtattttg cctgctatga aaacatgaaa      540

aggactttaa atgacgtttt ccaccaccaa ggaaacagcc acctagccaa cgggatagct      600

gggagtatgg ccaccctgct ccacgatgcg gtaatgaatc cagcagaagt ggtgaagcag      660

cgcttgcaga tgtacaactc gcagcaccgg tcagcaatca gctgcatccg gacggtgtgg      720

aggaccgagg ggttgggggc cttctaccgg agctacacca cgcagctgac catgaacatc      780

cccttccagt ccatccactt catcacctat gagttcctgc aggagcaggt caacccccac      840

cggacctaca acccgcagtc ccacatcatc tcaggcgggc tggccggggc cctcgccgcg      900

gccgccacga cccccctgga cgtctgtaag acccttctga acactcagga gaacgtggcc      960

ctctcgctgg ccaacatcag cggccggctg tcgggtatgg ccaatgcctt ccggacggtg     1020

taccagctca acggcctggc cggctacttc aaaggcatcc aggcgcgtgt catctaccag     1080

atgccctcca ccgccatttc ttggtctgtc tatgagttct tcaagtactt tctcaccaag     1140

cgccagctgg aaaatcgagc tccatactaa aggaagggat catagaatct tttcttaaag     1200

tcattctctg cctgcatcca gccccttgcc ctctcctcac acgtagatca tttttttttt     1260

gcagggtgct gcctatgggc cctctgctcc ccaatgcctt agagagagga ggggacggca     1320

cggccgctca ccggaaggct gtgtgcgggg acatccgagg tggtggtgga caggaaggac     1380

ttgggaaggg gagcgagaaa ttgctttttc tcttcctccc tgggcagaat gtagcttttc     1440

tgcttcactg tggcagcctc ctccctggat ccttagatcc cagaggaggg aagaaaattt     1500

gcagtgactg aaaacagtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaatttatgt atataaaagt tgcattacac agtacaaaat agatggataa tgtttatcct     1620

ttatttttct atgtagaagt ttttgaattt gtgtgtgtgc ttgtgcgtgt ctacacctag     1680

tattacggct gggactctcc agctgttttt gttgttgtta tgtttttaag agggttgaat     1740

tcttccatca ggtgaacgaa aaaggcaaca aagtaataaa tcagtgaatg tggccggcag     1800

ctgtgtttag cccctccaga tggaagtttc acttgaatgt aaaataataa agtttatatt     1860

ttgaa                                                                 1865


<210>  843
<211>  338
<212>  PRT
<213>  Homo Sapiens

<400>  843

Met Glu Leu Arg Ser Gly Ser Val Gly Ser Gln Ala Val Ala Arg Arg 
1               5                   10                  15      


Met Asp Gly Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly 
            20                  25                  30          


Ser Glu Asp Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His 
        35                  40                  45              


Met Thr Ala Gly Ala Met Ala Gly Ile Leu Glu His Ser Val Met Tyr 
    50                  55                  60                  


Pro Val Asp Ser Val Lys Thr Arg Met Gln Ser Leu Ser Pro Asp Pro 
65                  70                  75                  80  


Lys Ala Gln Tyr Thr Ser Ile Tyr Gly Ala Leu Lys Lys Ile Met Arg 
                85                  90                  95      


Thr Glu Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met Ile Met 
            100                 105                 110         


Gly Ala Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met 
        115                 120                 125             


Lys Arg Thr Leu Asn Asp Val Phe His His Gln Gly Asn Ser His Leu 
    130                 135                 140                 


Ala Asn Gly Ile Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val 
145                 150                 155                 160 


Met Asn Pro Ala Glu Val Val Lys Gln Arg Leu Gln Met Tyr Asn Ser 
                165                 170                 175     


Gln His Arg Ser Ala Ile Ser Cys Ile Arg Thr Val Trp Arg Thr Glu 
            180                 185                 190         


Gly Leu Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn 
        195                 200                 205             


Ile Pro Phe Gln Ser Ile His Phe Ile Thr Tyr Glu Phe Leu Gln Glu 
    210                 215                 220                 


Gln Val Asn Pro His Arg Thr Tyr Asn Pro Gln Ser His Ile Ile Ser 
225                 230                 235                 240 


Gly Gly Leu Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp 
                245                 250                 255     


Val Cys Lys Thr Leu Leu Asn Thr Gln Glu Asn Val Ala Leu Ser Leu 
            260                 265                 270         


Ala Asn Ile Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr 
        275                 280                 285             


Val Tyr Gln Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly Ile Gln Ala 
    290                 295                 300                 


Arg Val Ile Tyr Gln Met Pro Ser Thr Ala Ile Ser Trp Ser Val Tyr 
305                 310                 315                 320 


Glu Phe Phe Lys Tyr Phe Leu Thr Lys Arg Gln Leu Glu Asn Arg Ala 
                325                 330                 335     


Pro Tyr 
        


<210>  844
<211>  7556
<212>  DNA
<213>  Homo Sapiens

<400>  844
gcaggcgcct tcgcggaccg agcctgacgg agccggaggc tgggagccgc ggcggcctgg       60

ggaagtgttt ggattgtgag ctatttcaga actgttctca ggactcatta ttttaacatt      120

tgggagaaac acagccagaa gatgcacact tgactgaagg aggacaggga atctgaagac      180

tccggatgac atcagagcta cttttcaaca gccttctcaa ttttctttct cagaaagcag      240

aggctcagag cttggagaca gacgaacact gatatttgca tttaatgggg aacaaaagat      300

gaagaaggaa aaggaatata ttcactaagg attctatctg cttactgcta cagacctatg      360

tgttaaggaa ttcttctcct cctccttgcg tagaagttga tcagcactgt ggtcagactg      420

catttatctt gtcattgcca gaagaaatct tggacagaat gtaacagtac gtctctctct      480

gattgcgatg gaaggtgata aactgatact cctttattaa agttacatcg cactcaccac      540

agaaaaccat tctttaaagt gaatagaaac caagcccttg tgaacacttc tattgaacat      600

gactcatgga gaagagcttg gctctgatgt gcaccaggat tctattgttt taacttacct      660

agaaggatta ctaatgcatc aggcagcagg gggatcaggt actgccgttg acaaaaagtc      720

tgctgggcat aatgaagagg atcagaactt taacatttct ggcagtgcat ttcccacctg      780

tcaaagtaat ggtccagttc tcaatacaca tacatatcag gggtctggca tgctgcacct      840

caaaaaagcc agactgttgc agtcttctga ggactggaat gcagcaaagc ggaagaggct      900

gtctgattct atcatgaatt taaacgtaaa gaaggaagct ttgctagctg gcatggttga      960

cagtgtgcct aaaggcaaac aggatagcac attactggcc tctttgcttc agtcattcag     1020

ctctaggctg cagactgttg ctctgtcaca acaaatcagg cagagcctca aggagcaagg     1080

atatgccctc agtcatgatt ctttaaaagt ggagaaggat ttaaggtgct atggtgttgc     1140

atcaagtcac ttaaaaactt tgttgaagaa aagtaaagtt aaagatcaaa agcctgatac     1200

gaatcttcct gatgtgacta aaaacctcat cagagatagg tttgcagagt ctcctcatca     1260

tgttggacaa agtggaacaa aggtcatgag tgaaccgttg tcatgtgctg caagattaca     1320

ggctgttgca agcatggtgg aaaaaagggc tagtcctgcc acctcaccta aacctagtgt     1380

tgcttgtagc cagttagcat tacttctgtc aagcgaagcc catttgcagc agtattctcg     1440

agaacacgct ttaaaaacgc aaaatgcaaa tcaagcagca agtgaaagac ttgctgctat     1500

ggccagattg caagaaaatg gccagaagga tgttggcagt taccagctcc caaaaggaat     1560

gtcaagccat cttaatggtc aggcaagaac atcatcaagc aaactgatgg ctagcaaaag     1620

tagtgctaca gtgtttcaaa atccaatggg tatcattcct tcttccccta aaaatgcagg     1680

ttataagaac tcactggaaa gaaacaatat aaaacaagct gctaacaata gtttgctttt     1740

acatcttctt aaaagccaga ctatacctaa gccaatgaat ggacacagtc acagtgagag     1800

aggaagcatt tttgaggaaa gtagtacacc tacaactatt gatgaatatt cagataacaa     1860

tcctagtttt acagatgaca gcagtggtga tgaaagttct tattccaact gtgttcccat     1920

agacttgtct tgcaaacacc gaactgaaaa atcagaatct gaccaacctg tttccctgga     1980

taacttcact caatccttgc taaacacttg ggatccaaaa gtcccagatg tagatatcaa     2040

agaagatcaa gatacctcaa agaattctaa gctaaactca caccagaaag taacacttct     2100

tcaattgcta cttggccata agaatgaaga aaatgtagaa aaaaacacca gccctcaggg     2160

agtacacaat gatgtgagca agttcaatac acaaaattat gcaaggactt ctgtgataga     2220

aagccccagt acaaatcgga ctactccagt gagcactcca cctttactta catcaagcaa     2280

agcagggtct cccatcaatc tctctcaaca ctctctggtc atcaaatgga attccccacc     2340

atatgtctgc agtactcagt ctgaaaagct aacaaatact gcatctaacc actcaatgga     2400

ccttacaaaa agcaaagacc caccaggaga gaaaccagcc caaaatgaag gtgcacagaa     2460

ctctgcaacg tttagtgcca gtaagctgtt acaaaattta gcacaatgtg gaatgcagtc     2520

atccatgtca gtggaagagc agagacccag caaacagctg ttaactggaa acacagataa     2580

accgataggt atgattgata gattaaatag ccctttgctc tcaaataaaa caaatgcagt     2640

tgaagaaaat aaagcattta gtagtcaacc aacaggtcct gaaccagggc tttctggttc     2700

tgaaatagaa aatctgcttg aaagacgtac tgtcctccag ttgctcctgg ggaaccccaa     2760

caaagggaag agtgaaaaaa aagagaaaac tcccttaaga gatgaaagta ctcaggaaca     2820

ctcagagaga gctttaagtg aacaaatact gatggtgaaa ataaaatctg agccttgtga     2880

tgacttacaa attcctaaca caaatgtgca cttgagccat gatgctaaga gtgccccatt     2940

cttgggtatg gctcctgctg tgcagagaag cgcacctgcc ttaccagtgt ccgaagactt     3000

taaatcggag cctgtttcac ctcaggattt ttctttctcc aagaatggtc tgctaagtcg     3060

attgctaaga caaaatcaag atagttacct ggcagatgat tcagacagga gtcacagaaa     3120

taatgaaatg gcacttctag aatcaaagaa tctttgcatg gtccctaaga aaaggaagct     3180

ttatactgag ccattagaaa atccatttaa aaagatgaaa aacaacattg ttgatgctgc     3240

aaacaatcac agtgccccag aagtactgta tgggtccttg cttaaccagg aagagctgaa     3300

atttagcaga aatgatcttg aatttaaata tcctgctggt catggctcag ccagcgaaag     3360

tgaacacagg agttgggcca gagagagcaa aagctttaat gttctgaaac agctgcttct     3420

ctcagaaaac tgtgtgcgag atttgtcccc gcacagaagt aactctgtgg ctgacagtaa     3480

aaagaaagga cacaaaaata atgtgaccaa cagcaaacct gaatttagca tttcttcttt     3540

aaatggactg atgtacagtt ccactcagcc cagcagttgc atggataaca ggacattttc     3600

atacccaggt gtagtaaaaa ctcctgtgag tcctactttc cctgagcact tgggctgtgc     3660

agggtctaga ccagaatctg ggcttttgaa tgggtgttcc atgcccagtg agaaaggacc     3720

cattaagtgg gttatcactg atgcggagaa gaatgagtat gaaaaagact ctccaagatt     3780

gaccaaaacc aacccaatac tatattacat gcttcaaaaa ggaggcaatt ctgttaccag     3840

tcgagaaaca caagacaagg acatttggag ggaggcttca tctgctgaaa gtgtctcaca     3900

ggtcacagcc aaagaagagt tacttcctac tgcagaaacg aaagcttctt tctttaattt     3960

aagaagccct tacaatagcc atatgggaaa taatgcttct cgcccacaca gcgcaaatgg     4020

agaagtttat ggacttctgg gaagcgtgct aacgataaag aaagaatcag aataaaatgt     4080

acctgccatc cagttttgga tctttttaaa actaatgagt atgaacttga gatctgtata     4140

aataagagca tgatttgaaa aaaagcatgg tataattgaa acttttttca ttttgaaaag     4200

tattggttac tggtgatgtt gaaatatgca tactaatttt tgcttaacat tagatgtcat     4260

gaggaaacta ctgaactagc aattggttgt ttaacacttc tgtatgcatc agataacaac     4320

tgtgagtagc ctatgaatga aattctttta taaatattag gcataaatta aaatgtaaaa     4380

ctccattcat agtggattaa tgcattttgc tgcctttatt agggtacttt attttgcttt     4440

tcagaagtca gcctacataa cacattttta aagtctaaac tgttaaacaa ctctttaaag     4500

gataattatc caataaaaaa aaacctagtg ctgattcaca gcttattatc caattcaaaa     4560

ataaattaga aaaatatatg cttacatttt tcacttttgc taaaaagaaa aaaaaaaggt     4620

gtttattttt aactcttgga agaggttttg tggttcccaa tgtgtctgtc ccaccctgat     4680

ccttttcaat atatatttct ttaaaccttg tgctacttag taaaaattga ttacaattga     4740

gggaagtttg atagatcctt taaaaaaaag gcagatttcc attttttgta ttttaactac     4800

tttactaaat taatactcct ccttttacag aattagaaaa gttaacattt atctttaggt     4860

ggtttcctga aaagttgaat atttaagaaa ttgtttttaa cagaagcaaa atggcttttc     4920

tttggacagt tttcaccatc tcttgtaaaa gttaattctc accattcctg tggtacctgc     4980

gagtgttatg accaggattc cttaaacctg aactcagacc acttgcatta gaaccatctg     5040

gagcacttgt tttaaaatgc agattcatag gcagcatctc agatctacag aacaagaatc     5100

tctgctaagt ggacctggaa tcttccatct gcatcttaac atgctctcta ggtgtttctt     5160

gtgtttgaga accatgactt atgactttcc tcagaacatg agactgtaaa acaaaaacaa     5220

aaaactatgt gatgcctcta ttttccccaa tacagtcaca catcagctca aaatttgcaa     5280

tattgtagtt catatattac cgttatgtct ttggaaatcg ggttcagaac actttttatg     5340

acaaaaattg ggtggagggg ataactttca tatctggctc aacatctcag gaaaatctgt     5400

gattatttgt gtgttctaat gagtaacatc tacttagtta gccttaggga tggaaaaaca     5460

gggccactta ccaaactcag gtgattccag gatggtttgg aaacttctcc tgaatgcatc     5520

cttaaccttt attaaaacca ttgtcctaag aacaatgcca acaaagctta caacatttag     5580

tttaaaccca agaagggcac taaactcaga ttgactaaat aaaaagtaca aagggcacat     5640

atacgtgaca gaattgtaca caatcactcc attggatctt ttactttaaa gtagtgatga     5700

aaagtacatg ttgatactgt cttagaagaa attaatatat tagtgaagcc acatggggtt     5760

tcagttgcga aacaggtctg tttttatgtt cagtttgtac aatccacaat tcattcacca     5820

gatattttgt tcttaattgt gaaccaggtt agcaaatgac ctatcaaaaa ttattctata     5880

atcactacta gttaggatat tgatttaaaa ttgttctact tgaagtggtt tctaagattt     5940

ttatattaaa aataggtgtg atttcctaat atgatctaaa accctaaatg gttatttttc     6000

ctcagaatga tttgtaaata gctactggaa atattataca gtaataggag tgggtattat     6060

gcaacatcat ggagaagtga aggcataggc ttattctgac ataaaattcc actggccagt     6120

tgaatatatt ctattccatg tccatactat gacaatctta ttgtcaacac tatataaata     6180

agcttttaaa caagtcattt ttcttgatcg ttgtggaagg tttggagcct tagaggtatg     6240

tcagaaaaaa tatgttggta ttctcccttg ggtaggggga aatgaccttt ttacaagaga     6300

gtgaaattta ggtcagggaa aagaccaagg gccagcattg ctacttttgt gtgtgtgtgt     6360

gtgggttttg ttttgttttt ttggttggct ggttgttttc gttgttgtta acaaaggaat     6420

gagaatatgt aatacttaaa taaacatgac cacgaagaat gctgttctga tttactagag     6480

aatgttccca atttgaattt agggtgattt taaagaacag tgagaaaggg catacatcca     6540

cagattcact ttgtttatgc atatgtagat acaaggatgc acatatacac attttcaagg     6600

actattttag atatctagac aatttcttct aataaagtca tttgtgaaag ggtactacag     6660

cttattgaca tcagtaaggt agcattcatt acctgtttat tctctgctgc atcttacaga     6720

agagtaaact ggtgagagta tatattttat atatatatat atatatatat atataatatg     6780

tatatatata tatattgact tgttacatga agatgttaaa atcggttttt aaaggtgatg     6840

taaatagtga tttccttaat gaaaaataca tattttgtat tgttctaatg caacagaaaa     6900

gccttttaat ctctttggtt cctgtatatt ccatgtataa gtgtaaatat aatcagacag     6960

gtttaaaagt tgtgcatgta tgtatacagt tgcaagtctg gacaaatgta tagaataaac     7020

cttttattta agttgtgatt acctgctgca tgaaaagtgc atgggggacc ctgtgcatct     7080

gtgcatttgg caaaatgtct taacaaatca gatcagatgt tcatcctaac atgacagtat     7140

tccatttctg gacatgacgt ctgtggttta agctttgtga aagaatgtgc tttgattcga     7200

agggtcttaa agaatttttt taatcgtcaa ccacttttaa acataaagaa ttcacacaac     7260

tactttcatg aattttttaa tcccattgca aacattattc caagagtatc ccagtattag     7320

caatactgga atataggcac attaccattc atagtaagaa ttctggtgtt tacacaacca     7380

aatttgatgc gatctgctca gtaatataat ttgccatttt tattagaaat ttaatttctt     7440

catgtgatgt catgaaactg tacatactgc agtgtgaatt tttttgtttt gttttttaat     7500

cttttagtgt ttacttcctg cagtgaattt gaataaatga gaaaaaatgc attgtc         7556


<210>  845
<211>  1158
<212>  PRT
<213>  Homo Sapiens

<400>  845

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15      


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30          


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45              


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60                  


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80  


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95      


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110         


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125             


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140                 


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175     


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190         


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205             


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220                 


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240 


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255     


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270         


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285             


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300                 


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320 


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335     


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350         


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365             


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380                 


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400 


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415     


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430         


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445             


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460                 


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495     


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510         


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525             


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540                 


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560 


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575     


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590         


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605             


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620                 


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640 


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655     


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670         


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685             


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700                 


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735     


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750         


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765             


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780                 


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800 


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815     


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830         


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845             


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860                 


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880 


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895     


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910         


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925             


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940                 


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960 


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975     


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990         


Ser Cys Met Asp Asn Arg Thr Phe  Ser Tyr Pro Gly Val  Val Lys Thr 
        995                 1000                 1005             


Pro Val  Ser Pro Thr Phe Pro  Glu His Leu Gly Cys  Ala Gly Ser 
    1010                 1015                 1020             


Arg Pro  Glu Ser Gly Leu Leu  Asn Gly Cys Ser Met  Pro Ser Glu 
    1025                 1030                 1035             


Lys Gly  Pro Ile Lys Trp Val  Ile Thr Asp Ala Glu  Lys Asn Glu 
    1040                 1045                 1050             


Tyr Glu  Lys Asp Ser Pro Arg  Leu Thr Lys Thr Asn  Pro Ile Leu 
    1055                 1060                 1065             


Tyr Tyr  Met Leu Gln Lys Gly  Gly Asn Ser Val Thr  Ser Arg Glu 
    1070                 1075                 1080             


Thr Gln  Asp Lys Asp Ile Trp  Arg Glu Ala Ser Ser  Ala Glu Ser 
    1085                 1090                 1095             


Val Ser  Gln Val Thr Ala Lys  Glu Glu Leu Leu Pro  Thr Ala Glu 
    1100                 1105                 1110             


Thr Lys  Ala Ser Phe Phe Asn  Leu Arg Ser Pro Tyr  Asn Ser His 
    1115                 1120                 1125             


Met Gly  Asn Asn Ala Ser Arg  Pro His Ser Ala Asn  Gly Glu Val 
    1130                 1135                 1140             


Tyr Gly  Leu Leu Gly Ser Val  Leu Thr Ile Lys Lys  Glu Ser Glu 
    1145                 1150                 1155             


<210>  846
<211>  3265
<212>  DNA
<213>  Homo Sapiens

<400>  846
cgagggcgag gcggccacgc ggggccggga atgcccgcgg tgcggggccc cagagccgcc       60

cggtggtcgt gtccgggcga tggctcttcg cctggtcgcc gacttcgacc tcgggaagga      120

cgtgctcccg tggttgcggg cgcagcgggc agtgtcggag gccagcgggg ccggaagcgg      180

cggcgcagat gttttagaaa acgattatga gagcttacat gtattaaatg ttgaaagaaa      240

tggaaatatt atttatacct ataaggatga taagggaaat gtcgtctttg gattatatga      300

ttgtcaaacc agacaaaatg agcttctata tacctttgag aaagacttgc aagttttcag      360

ttgctctgtc aacagtgaaa ggactttgct tgctgcaagt ttagttcagt ctactaaaga      420

aggaaaaagg aacgaacttc aaccaggatc aaagtgcttg actttgttgg ttgaaatcca      480

ccctgttaac aatgtgaagg ttctaaaggc tgtggatagc tatatttggg ttcagtttct      540

ctacccacat attgaaagtc atcctcttcc agagaaccat ctgttactga tttcagaaga      600

gaaatatatt gaacaatttc gtatccatgt cgcccaagaa gatggaaata gagtggtgat      660

taaaaattct ggccatctcc caagagacag aatagctgag gatttcgttt gggctcagtg      720

ggatatgtca gaacagagat tatattacat tgacctgaag aaatcaagga gtatcttaaa      780

atgtatccag ttttatgctg atgagagcta taacttaatg tttgaagtac ccttggacat      840

atcattaagc aactcaggat ttaaacttgt caactttgga tgtgattatc atcaataccg      900

agataaattt tccaaacacc tgactctgtg tgtttttacc aaccatacag gaagtttgtg      960

tgtatgttac agcccgaagt gtgcctcttg gggacaaatc acatattcag tgttttacat     1020

tcataaagga cacagcaaga ccttcaccac ttctcttgag aatgttgggt cacacatgac     1080

aaagggcatt acttttctca accttgacta ttatgtggct gtttacttac ctggtcattt     1140

cttccaccta cttaatgttc aacatccaga cctgatctgc cacaatctct ttctgacagg     1200

aaataatgaa atgattgata tgctacctca ttgcccttta cagtcattgt cagggtccct     1260

ggtattggat tgttgttctg gaaagctcta tagagcactg ctcagccagt cgtctttatt     1320

acagcttctg cagaacactt gcttagactg tgagaagatg gctgcgttgc actgcgcgct     1380

ctactgcggt caaggtgcgc agttcctgga agcccagatt attcagtgga tttctgagaa     1440

tgtctctgcc tgccattcat ttgacctcat tcaggaattt ataattgctt cttcatactg     1500

gagtgtatat tcagagacaa gtaacatgga caaactattg ccacattcct cagtgctcac     1560

ttggaataca gaaattcctg gaataactct tgtgacagaa gacattgcat tgcctcttat     1620

gaaggtgctc agctttaagg gctactggga aaaactgaac tccaacctag aatatgttaa     1680

gtacgccaag ccacacttcc actataacaa cagtgtggtc aggagagagt ggcacaacct     1740

gatctctgaa gagaaaacag gaaaaagaag gtctgcggca tacgtgagga atattcttga     1800

taatgcagta aaggtgattt ctaacctaga agcaagaaat ttggggccaa gattaacacc     1860

cctcctgcag gaggaagaca gccaccagcg gctgctcatg gggctgatgg tgtctgagct     1920

aaaagaccat tttttgagac acctacaggg tgtagaaaag aagaaaattg aacagatggt     1980

tctggactac atttcaaaac tgctggatct catttgccac atcgtagaaa ccaattggag     2040

gaaacataat cttcattcct gggttctcca cttcaatagt cgtggcagtg ctgctgaatt     2100

tgcagttttt cacatcatga ccaggattct ggaagctaca aacagtttgt ttttacctct     2160

gcctcctggt tttcatactc tgcacaccat cctcggggtc cagtgtctcc ctttgcataa     2220

cctgctgcat tgcattgaca gtggagtgtt gcttctcact gaaacagctg tcataaggct     2280

catgaaagat ctggataata cagagaaaaa tgaaaaactg aaattcagta tcattgtgcg     2340

gcttcctccg cttattgggc agaagatttg tagactttgg gatcatccta tgagttctaa     2400

catcatttcg cggaaccacg tgacgcgact gcttcagaac tataagaaac agcctcggaa     2460

ttctatgatt aacaagtcat cgttcagtgt agaatttctg cctctgaact acttcattga     2520

aattctgaca gatatagagt cctccaatca agccctgtat ccttttgaag gacatgacaa     2580

tgtggatgca gaatttgtag aggaagcagc tctgaaacac accgcgatgc ttttaggctt     2640

atgaaaaaga aaacgcaatt ggatctgctg ctgccatttt aatcttgctc attaacctta     2700

ctcctttgag aattctttaa caatatttaa aattggtaac aaaaatagtt tagccataat     2760

tgtttagcca tgtgagtttc aggttggtac acgttcagac agaactgctg tatcacattc     2820

caattttgaa tagccagtga gcaatcaagt gtagagaaat gataaatggc ctaagaaggc     2880

atacagtggc ataaacgatg ctcttcctag tagcttaata ggccacaagc tagtttctgt     2940

tgcactctga aataaaatat gctttaaaaa tgtagggaac agtgcttaga aaagcaaaaa     3000

ctaggtgtgt cattgaaata ataggcataa aaattaaatg ttacataaga acactatttg     3060

gaaagagggt ccttttaaaa actgaatttg tactaaatca gatttgccat gtccagtaca     3120

gaataatttg tacttagtat ttgcagcagg gtttgtcttt gtgaattcag atgaaacata     3180

tttatttttt tttatttata aaaggttgat ttaggaatat tttgtcagtc attaaaaaac     3240

ctgaaaacat aaaaaaaaaa aaaaa                                           3265


<210>  847
<211>  854
<212>  PRT
<213>  Homo Sapiens

<400>  847

Met Ala Leu Arg Leu Val Ala Asp Phe Asp Leu Gly Lys Asp Val Leu 
1               5                   10                  15      


Pro Trp Leu Arg Ala Gln Arg Ala Val Ser Glu Ala Ser Gly Ala Gly 
            20                  25                  30          


Ser Gly Gly Ala Asp Val Leu Glu Asn Asp Tyr Glu Ser Leu His Val 
        35                  40                  45              


Leu Asn Val Glu Arg Asn Gly Asn Ile Ile Tyr Thr Tyr Lys Asp Asp 
    50                  55                  60                  


Lys Gly Asn Val Val Phe Gly Leu Tyr Asp Cys Gln Thr Arg Gln Asn 
65                  70                  75                  80  


Glu Leu Leu Tyr Thr Phe Glu Lys Asp Leu Gln Val Phe Ser Cys Ser 
                85                  90                  95      


Val Asn Ser Glu Arg Thr Leu Leu Ala Ala Ser Leu Val Gln Ser Thr 
            100                 105                 110         


Lys Glu Gly Lys Arg Asn Glu Leu Gln Pro Gly Ser Lys Cys Leu Thr 
        115                 120                 125             


Leu Leu Val Glu Ile His Pro Val Asn Asn Val Lys Val Leu Lys Ala 
    130                 135                 140                 


Val Asp Ser Tyr Ile Trp Val Gln Phe Leu Tyr Pro His Ile Glu Ser 
145                 150                 155                 160 


His Pro Leu Pro Glu Asn His Leu Leu Leu Ile Ser Glu Glu Lys Tyr 
                165                 170                 175     


Ile Glu Gln Phe Arg Ile His Val Ala Gln Glu Asp Gly Asn Arg Val 
            180                 185                 190         


Val Ile Lys Asn Ser Gly His Leu Pro Arg Asp Arg Ile Ala Glu Asp 
        195                 200                 205             


Phe Val Trp Ala Gln Trp Asp Met Ser Glu Gln Arg Leu Tyr Tyr Ile 
    210                 215                 220                 


Asp Leu Lys Lys Ser Arg Ser Ile Leu Lys Cys Ile Gln Phe Tyr Ala 
225                 230                 235                 240 


Asp Glu Ser Tyr Asn Leu Met Phe Glu Val Pro Leu Asp Ile Ser Leu 
                245                 250                 255     


Ser Asn Ser Gly Phe Lys Leu Val Asn Phe Gly Cys Asp Tyr His Gln 
            260                 265                 270         


Tyr Arg Asp Lys Phe Ser Lys His Leu Thr Leu Cys Val Phe Thr Asn 
        275                 280                 285             


His Thr Gly Ser Leu Cys Val Cys Tyr Ser Pro Lys Cys Ala Ser Trp 
    290                 295                 300                 


Gly Gln Ile Thr Tyr Ser Val Phe Tyr Ile His Lys Gly His Ser Lys 
305                 310                 315                 320 


Thr Phe Thr Thr Ser Leu Glu Asn Val Gly Ser His Met Thr Lys Gly 
                325                 330                 335     


Ile Thr Phe Leu Asn Leu Asp Tyr Tyr Val Ala Val Tyr Leu Pro Gly 
            340                 345                 350         


His Phe Phe His Leu Leu Asn Val Gln His Pro Asp Leu Ile Cys His 
        355                 360                 365             


Asn Leu Phe Leu Thr Gly Asn Asn Glu Met Ile Asp Met Leu Pro His 
    370                 375                 380                 


Cys Pro Leu Gln Ser Leu Ser Gly Ser Leu Val Leu Asp Cys Cys Ser 
385                 390                 395                 400 


Gly Lys Leu Tyr Arg Ala Leu Leu Ser Gln Ser Ser Leu Leu Gln Leu 
                405                 410                 415     


Leu Gln Asn Thr Cys Leu Asp Cys Glu Lys Met Ala Ala Leu His Cys 
            420                 425                 430         


Ala Leu Tyr Cys Gly Gln Gly Ala Gln Phe Leu Glu Ala Gln Ile Ile 
        435                 440                 445             


Gln Trp Ile Ser Glu Asn Val Ser Ala Cys His Ser Phe Asp Leu Ile 
    450                 455                 460                 


Gln Glu Phe Ile Ile Ala Ser Ser Tyr Trp Ser Val Tyr Ser Glu Thr 
465                 470                 475                 480 


Ser Asn Met Asp Lys Leu Leu Pro His Ser Ser Val Leu Thr Trp Asn 
                485                 490                 495     


Thr Glu Ile Pro Gly Ile Thr Leu Val Thr Glu Asp Ile Ala Leu Pro 
            500                 505                 510         


Leu Met Lys Val Leu Ser Phe Lys Gly Tyr Trp Glu Lys Leu Asn Ser 
        515                 520                 525             


Asn Leu Glu Tyr Val Lys Tyr Ala Lys Pro His Phe His Tyr Asn Asn 
    530                 535                 540                 


Ser Val Val Arg Arg Glu Trp His Asn Leu Ile Ser Glu Glu Lys Thr 
545                 550                 555                 560 


Gly Lys Arg Arg Ser Ala Ala Tyr Val Arg Asn Ile Leu Asp Asn Ala 
                565                 570                 575     


Val Lys Val Ile Ser Asn Leu Glu Ala Arg Asn Leu Gly Pro Arg Leu 
            580                 585                 590         


Thr Pro Leu Leu Gln Glu Glu Asp Ser His Gln Arg Leu Leu Met Gly 
        595                 600                 605             


Leu Met Val Ser Glu Leu Lys Asp His Phe Leu Arg His Leu Gln Gly 
    610                 615                 620                 


Val Glu Lys Lys Lys Ile Glu Gln Met Val Leu Asp Tyr Ile Ser Lys 
625                 630                 635                 640 


Leu Leu Asp Leu Ile Cys His Ile Val Glu Thr Asn Trp Arg Lys His 
                645                 650                 655     


Asn Leu His Ser Trp Val Leu His Phe Asn Ser Arg Gly Ser Ala Ala 
            660                 665                 670         


Glu Phe Ala Val Phe His Ile Met Thr Arg Ile Leu Glu Ala Thr Asn 
        675                 680                 685             


Ser Leu Phe Leu Pro Leu Pro Pro Gly Phe His Thr Leu His Thr Ile 
    690                 695                 700                 


Leu Gly Val Gln Cys Leu Pro Leu His Asn Leu Leu His Cys Ile Asp 
705                 710                 715                 720 


Ser Gly Val Leu Leu Leu Thr Glu Thr Ala Val Ile Arg Leu Met Lys 
                725                 730                 735     


Asp Leu Asp Asn Thr Glu Lys Asn Glu Lys Leu Lys Phe Ser Ile Ile 
            740                 745                 750         


Val Arg Leu Pro Pro Leu Ile Gly Gln Lys Ile Cys Arg Leu Trp Asp 
        755                 760                 765             


His Pro Met Ser Ser Asn Ile Ile Ser Arg Asn His Val Thr Arg Leu 
    770                 775                 780                 


Leu Gln Asn Tyr Lys Lys Gln Pro Arg Asn Ser Met Ile Asn Lys Ser 
785                 790                 795                 800 


Ser Phe Ser Val Glu Phe Leu Pro Leu Asn Tyr Phe Ile Glu Ile Leu 
                805                 810                 815     


Thr Asp Ile Glu Ser Ser Asn Gln Ala Leu Tyr Pro Phe Glu Gly His 
            820                 825                 830         


Asp Asn Val Asp Ala Glu Phe Val Glu Glu Ala Ala Leu Lys His Thr 
        835                 840                 845             


Ala Met Leu Leu Gly Leu 
    850                 


<210>  848
<211>  4704
<212>  DNA
<213>  Homo Sapiens

<400>  848
ggagagggag aaggctctcg ggcggagaga ggtcctgccc agctgttggc gaggagtttc       60

ctgtttcccc cgcagcgctg agttgaagtt gagtgagtca ctcgcgcgca cggagcgacg      120

acacccccgc gcgtgcaccc gctcgggaca ggagccggac tcctgtgcag cttccctcgg      180

ccgccggggg cctccccgcg cctcgccggc ctccaggccc cctcctggct ggcgagcggg      240

cgccacatct ggcccgcaca tctgcgctgc cggcccggcg cggggtccgg agagggcgcg      300

gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg ctgcgctggg ggctcggtct      360

atgacgagca gcggggtctg ccatgggtcg ggggctgctc aggggcctgt ggccgctgca      420

catcgtcctg tggacgcgta tcgccagcac gatcccaccg cacgttcaga agtcggatgt      480

ggaaatggag gcccagaaag atgaaatcat ctgccccagc tgtaatagga ctgcccatcc      540

actgagacat attaataacg acatgatagt cactgacaac aacggtgcag tcaagtttcc      600

acaactgtgt aaattttgtg atgtgagatt ttccacctgt gacaaccaga aatcctgcat      660

gagcaactgc agcatcacct ccatctgtga gaagccacag gaagtctgtg tggctgtatg      720

gagaaagaat gacgagaaca taacactaga gacagtttgc catgacccca agctccccta      780

ccatgacttt attctggaag atgctgcttc tccaaagtgc attatgaagg aaaaaaaaaa      840

gcctggtgag actttcttca tgtgttcctg tagctctgat gagtgcaatg acaacatcat      900

cttctcagaa gaatataaca ccagcaatcc tgacttgttg ctagtcatat ttcaagtgac      960

aggcatcagc ctcctgccac cactgggagt tgccatatct gtcatcatca tcttctactg     1020

ctaccgcgtt aaccggcagc agaagctgag ttcaacctgg gaaaccggca agacgcggaa     1080

gctcatggag ttcagcgagc actgtgccat catcctggaa gatgaccgct ctgacatcag     1140

ctccacgtgt gccaacaaca tcaaccacaa cacagagctg ctgcccattg agctggacac     1200

cctggtgggg aaaggtcgct ttgctgaggt ctataaggcc aagctgaagc agaacacttc     1260

agagcagttt gagacagtgg cagtcaagat ctttccctat gaggagtatg cctcttggaa     1320

gacagagaag gacatcttct cagacatcaa tctgaagcat gagaacatac tccagttcct     1380

gacggctgag gagcggaaga cggagttggg gaaacaatac tggctgatca ccgccttcca     1440

cgccaagggc aacctacagg agtacctgac gcggcatgtc atcagctggg aggacctgcg     1500

caagctgggc agctccctcg cccgggggat tgctcacctc cacagtgatc acactccatg     1560

tgggaggccc aagatgccca tcgtgcacag ggacctcaag agctccaata tcctcgtgaa     1620

gaacgaccta acctgctgcc tgtgtgactt tgggctttcc ctgcgtctgg accctactct     1680

gtctgtggat gacctggcta acagtgggca ggtgggaact gcaagataca tggctccaga     1740

agtcctagaa tccaggatga atttggagaa tgttgagtcc ttcaagcaga ccgatgtcta     1800

ctccatggct ctggtgctct gggaaatgac atctcgctgt aatgcagtgg gagaagtaaa     1860

agattatgag cctccatttg gttccaaggt gcgggagcac ccctgtgtcg aaagcatgaa     1920

ggacaacgtg ttgagagatc gagggcgacc agaaattccc agcttctggc tcaaccacca     1980

gggcatccag atggtgtgtg agacgttgac tgagtgctgg gaccacgacc cagaggcccg     2040

tctcacagcc cagtgtgtgg cagaacgctt cagtgagctg gagcatctgg acaggctctc     2100

ggggaggagc tgctcggagg agaagattcc tgaagacggc tccctaaaca ctaccaaata     2160

gctcttctgg ggcaggctgg gccatgtcca aagaggctgc ccctctcacc aaagaacaga     2220

ggcagcagga agctgcccct gaactgatgc ttcctggaaa accaaggggg tcactcccct     2280

ccctgtaagc tgtggggata agcagaaaca acagcagcag ggagtgggtg acatagagca     2340

ttctatgcct ttgacattgt cataggataa gctgtgttag cacttcctca ggaaatgaga     2400

ttgattttta caatagccaa taacatttgc actttattaa tgcctgtata taaatatgaa     2460

tagctatgtt ttatatatat atatatatat ctatatatgt ctatagctct atatatatag     2520

ccataccttg aaaagagaca aggaaaaaca tcaaatattc ccaggaaatt ggttttattg     2580

gagaactcca gaaccaagca gagaaggaag ggacccatga cagcattagc atttgacaat     2640

cacacatgca gtggttctct gactgtaaaa cagtgaactt tgcatgagga aagaggctcc     2700

atgtctcaca gccagctatg accacattgc acttgctttt gcaaaataat cattccctgc     2760

ctagcacttc tcttctggcc atggaactaa gtacagtggc actgtttgag gaccagtgtt     2820

cccggggttc ctgtgtgccc ttatttctcc tggacttttc atttaagctc caagccccaa     2880

atctgggggg ctagtttaga aactctccct caacctagtt tagaaactct accccatctt     2940

taataccttg aatgttttga accccacttt ttaccttcat gggttgcaga aaaatcagaa     3000

cagatgtccc catccatgcg attgccccac catctactaa tgaaaaattg ttcttttttt     3060

catctttccc ctgcacttat gttactattc tctgctccca gccttcatcc ttttctaaaa     3120

aggagcaaat tctcactcta ggctttatcg tgtttacttt ttcattacac ttgacttgat     3180

tttctagttt tctatacaaa caccaatggg ttccatcttt ctgggctcct gattgctcaa     3240

gcacagtttg gcctgatgaa gaggatttca actacacaat actatcattg tcaggactat     3300

gacctcaggc actctaaaca tatgttttgt ttggtcagca cagcgtttca aaaagtgaag     3360

ccactttata aatatttgga gattttgcag gaaaatctgg atccccaggt aaggatagca     3420

gatggttttc agttatctcc agtccacgtt cacaaaatgt gaaggtgtgg agacacttac     3480

aaagctgcct cacttctcac tgtaaacatt agctctttcc actgcctacc tggaccccag     3540

tctaggaatt aaatctgcac ctaaccaagg tcccttgtaa gaaatgtcca ttcaagcagt     3600

cattctctgg gtatataata tgattttgac taccttatct ggtgttaaga tttgaagttg     3660

gccttttatt ggactaaagg ggaactcctt taagggtctc agttagccca agtttctttt     3720

gcttatatgt taatagtttt accctctgca ttggagagag gagtgcttta ctccaagaag     3780

ctttcctcat ggttaccgtt ctctccatca tgccagcctt ctcaaccttt gcagaaatta     3840

ctagagagga tttgaatgtg ggacacaaag gtcccatttg cagttagaaa atttgtgtcc     3900

acaaggacaa gaacaaagta tgagctttaa aactccatag gaaacttgtt aatcaacaaa     3960

gaagtgttaa tgctgcaagt aatctctttt ttaaaacttt ttgaagctac ttattttcag     4020

ccaaatagga atattagaga gggactggta gtgagaatat cagctctgtt tggatggtgg     4080

aaggtctcat tttattgaga tttttaagat acatgcaaag gtttggaaat agaacctcta     4140

ggcaccctcc tcagtgtggg tgggctgaga gttaaagaca gtgtggctgc agtagcatag     4200

aggcgcctag aaattccact tgcaccgtag ggcatgctga taccatccca atagctgttg     4260

cccattgacc tctagtggtg agtttctaga atactggtcc attcatgaga tattcaagat     4320

tcaagagtat tctcacttct gggttatcag cataaactgg aatgtagtgt cagaggatac     4380

tgtggcttgt tttgtttatg tttttttttc ttattcaaga aaaaagacca aggaataaca     4440

ttctgtagtt cctaaaaata ctgacttttt tcactactat acataaaggg aaagttttat     4500

tcttttatgg aacacttcag ctgtactcat gtattaaaat aggaatgtga atgctatata     4560

ctctttttat atcaaaagtc tcaagcactt atttttattc tatgcattgt ttgtctttta     4620

cataaataaa atgtttatta gattgaataa agcaaaatac tcaggtgagc atcctgcctc     4680

ctgttcccat tcctagtagc taaa                                            4704


<210>  849
<211>  592
<212>  PRT
<213>  Homo Sapiens

<400>  849

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  850
<211>  1849
<212>  DNA
<213>  Homo Sapiens

<400>  850
gcagcggggc tgccgctggt tggtccgcac gtggaacctc tcctggtcct gttgacccgg       60

gcccctcgga acctccagct tggtccggtc tgggactgga agcctgccat ggcggcttct      120

gcggcggaga cgcgcgtgtt tctggaggtg cggggacagc tgcagagcgc gcttctgatc      180

ctgggagaac cgaaagaagg aggtatgccc atgaatattt ccataatgcc atcttcactc      240

cagatgaaaa cccctgaagg ctgcacagaa atccagcttc cagcagaggt caggcttgta      300

ccttcctctt gccgtgggct acagtttgtt gttggagatg gactgcacct gcgactgcag      360

acgcaagcaa aattaggcac aaaactgatt tcaatgttta atcaaagctc gcaaacccaa      420

gaatgttgca cgttttattg ccaatcctgc ggtgaagtca taataaaaga caggaagctc      480

ctcagggtgc tcccactgcc gagtgagaac tggggagctc tagttggaga atggtgttgt      540

catcctgacc cctttgctaa taaatcactt catccgcaag agaatgactg ttttattgga      600

gactctttct tcttggtgaa tttaagaacc agtttgtggc agcaaagacc tgaactatcc      660

ccagtggaga tgtgctgtgt ttcttctgac aaccattgta aattggaacc aaaggcaaat      720

accaaagtaa tttgtaagcg ttgcaaggta atgttgggag agaccgtgtc atcagaaacc      780

accaagtttt atatgacaga gataattatt cagtcatctg agaggagttt tcctatcata      840

ccaaggtctt ggtttgtcca gagcgtgatc gcccagtgtc tggtgcagct ctcctctgct      900

agaagcactt ttagattcac gattcaaggt caggatgaca aagtgtatat cttgctatgg      960

cttttaaatt cagacagttt ggtgattgaa tctttgagaa attccaaata tatcaaaaaa     1020

ttccccttgt tggaaaacac attcaaagcc gattctagtt ctgcctggag tgctgtcaag     1080

gtcctctacc agccatgcat caaaagcagg aatgaaaaac ttgtcagctt gtgggaaagt     1140

gacatcagcg tccacccgct aaccctgccc tctgcaacct gcttggagct gctgttgata     1200

ttgtcaaaga gtaatgccaa tctgccttca tcccttcgcc gtgtgaattc ctttcaggtg     1260

gcctttttga agatgtaact attagagctg ggcattctcc tcccccggca gacagctctc     1320

aagcaggagc acaccgaggc cagcagtcag ctcaggaggc atcaattaca aagacaagaa     1380

ccagagctat gggataagag cattgcattg aagttttaag tttacttgtt tgcatgtatt     1440

ctctaagaga agagttaact ttagatcttt gaaaacccag gactgtgaag aaagtcatag     1500

tagcaggttg aggcaagtgt agaagttaca tctctatttc ccacagagag gaatattcac     1560

atatgtgcag tgtcagcacc acctggaagg ttattaccta atagagatcc atctgtcctg     1620

tgtggaatcc agtgaggaat tttattggtg gaactgaatg ttaactgctg taaatcctag     1680

gaaataaact tttaaagagt ttctcaggat gatttaaaac aaattttaaa aaagaaaagt     1740

agaaaacatt ttatacttta ttcagaggag atgctcaata gatgtttgtt gaatgaatga     1800

ttatcaaatt aaaggatttc ctatttatgc aaaaaaaaaa aaaaaaaaa                 1849


<210>  851
<211>  389
<212>  PRT
<213>  Homo Sapiens

<400>  851

Met Ala Ala Ser Ala Ala Glu Thr Arg Val Phe Leu Glu Val Arg Gly 
1               5                   10                  15      


Gln Leu Gln Ser Ala Leu Leu Ile Leu Gly Glu Pro Lys Glu Gly Gly 
            20                  25                  30          


Met Pro Met Asn Ile Ser Ile Met Pro Ser Ser Leu Gln Met Lys Thr 
        35                  40                  45              


Pro Glu Gly Cys Thr Glu Ile Gln Leu Pro Ala Glu Val Arg Leu Val 
    50                  55                  60                  


Pro Ser Ser Cys Arg Gly Leu Gln Phe Val Val Gly Asp Gly Leu His 
65                  70                  75                  80  


Leu Arg Leu Gln Thr Gln Ala Lys Leu Gly Thr Lys Leu Ile Ser Met 
                85                  90                  95      


Phe Asn Gln Ser Ser Gln Thr Gln Glu Cys Cys Thr Phe Tyr Cys Gln 
            100                 105                 110         


Ser Cys Gly Glu Val Ile Ile Lys Asp Arg Lys Leu Leu Arg Val Leu 
        115                 120                 125             


Pro Leu Pro Ser Glu Asn Trp Gly Ala Leu Val Gly Glu Trp Cys Cys 
    130                 135                 140                 


His Pro Asp Pro Phe Ala Asn Lys Ser Leu His Pro Gln Glu Asn Asp 
145                 150                 155                 160 


Cys Phe Ile Gly Asp Ser Phe Phe Leu Val Asn Leu Arg Thr Ser Leu 
                165                 170                 175     


Trp Gln Gln Arg Pro Glu Leu Ser Pro Val Glu Met Cys Cys Val Ser 
            180                 185                 190         


Ser Asp Asn His Cys Lys Leu Glu Pro Lys Ala Asn Thr Lys Val Ile 
        195                 200                 205             


Cys Lys Arg Cys Lys Val Met Leu Gly Glu Thr Val Ser Ser Glu Thr 
    210                 215                 220                 


Thr Lys Phe Tyr Met Thr Glu Ile Ile Ile Gln Ser Ser Glu Arg Ser 
225                 230                 235                 240 


Phe Pro Ile Ile Pro Arg Ser Trp Phe Val Gln Ser Val Ile Ala Gln 
                245                 250                 255     


Cys Leu Val Gln Leu Ser Ser Ala Arg Ser Thr Phe Arg Phe Thr Ile 
            260                 265                 270         


Gln Gly Gln Asp Asp Lys Val Tyr Ile Leu Leu Trp Leu Leu Asn Ser 
        275                 280                 285             


Asp Ser Leu Val Ile Glu Ser Leu Arg Asn Ser Lys Tyr Ile Lys Lys 
    290                 295                 300                 


Phe Pro Leu Leu Glu Asn Thr Phe Lys Ala Asp Ser Ser Ser Ala Trp 
305                 310                 315                 320 


Ser Ala Val Lys Val Leu Tyr Gln Pro Cys Ile Lys Ser Arg Asn Glu 
                325                 330                 335     


Lys Leu Val Ser Leu Trp Glu Ser Asp Ile Ser Val His Pro Leu Thr 
            340                 345                 350         


Leu Pro Ser Ala Thr Cys Leu Glu Leu Leu Leu Ile Leu Ser Lys Ser 
        355                 360                 365             


Asn Ala Asn Leu Pro Ser Ser Leu Arg Arg Val Asn Ser Phe Gln Val 
    370                 375                 380                 


Ala Phe Leu Lys Met 
385                 


<210>  852
<211>  2577
<212>  DNA
<213>  Homo Sapiens

<400>  852
ggcatcgggt ttctggctcg tgatttgccg gagctcctgc gctccccttc tccaccccct       60

ccggctgtgt gagaggtcag cagaggggcg gtctgcgggg acaacaatgg cggggttctg      120

ggtcgggaca gcaccgctgg tcgctgccgg acggcgtggg cggtggccgc cgcagcagct      180

gatgctgagc gcggcgctgc ggaccctgaa gcatgttctg tactattcaa gacagtgctt      240

aatggtgtcc cgtaatcttg gttcagtggg atatgatcct aatgaaaaaa cttttgataa      300

aattcttgtt gctaatagag gagaaattgc atgtcgggtt attagaactt gcaagaagat      360

gggcattaag acagttgcca tccacagtga tgttgatgct agttctgttc atgtgaaaat      420

ggcggatgag gctgtctgtg ttggcccagc tcccaccagt aaaagctacc tcaacatgga      480

tgccatcatg gaagccatta agaaaaccag ggcccaagct gtacatccag gttatggatt      540

cctttcagaa aacaaagaat ttgccagatg tttggcagca gaagatgtcg ttttcattgg      600

acctgacaca catgctattc aagccatggg cgacaagatt gaaagcaaat tattagctaa      660

gaaagcagag gttaatacaa tccctggctt tgatggagta gtcaaggatg cagaagaagc      720

tgtcagaatt gcaagggaaa ttggctaccc tgtcatgatc aaggcctcag caggtggtgg      780

tgggaaaggc atgcgcattg cttgggatga tgaagagacc agggatggtt ttagattgtc      840

atctcaagaa gctgcttcta gttttggcga tgatagacta ctaatagaaa aatttattga      900

taatcctcgt catatagaaa tccaggttct aggtgataaa catgggaatg ctttatggct      960

taatgaaaga gagtgctcaa ttcagagaag aaatcagaag gtggtggagg aagcaccaag     1020

catttttttg gatgcggaga ctcgaagagc gatgggagaa caagctgtag ctcttgccag     1080

agcagtaaaa tattcctctg ctgggaccgt ggagttcctt gtggactcta agaagaattt     1140

ttatttcttg gaaatgaata caagactcca ggttgagcat cctgtcacag aatgcattac     1200

tggcctggac ctagtccagg aaatgatccg tgttgctaag ggctaccctc tcaggcacaa     1260

acaagctgat attcgcatca acggctgggc agttgaatgt cgggtttatg ctgaggaccc     1320

ctacaagtct tttggtttac catctattgg gagattgtct cagtaccaag aaccgttaca     1380

tctacctggt gtccgagtgg acagtggcat ccaaccagga agtgatatta gcatttatta     1440

tgatcctatg atttcaaaac taatcacata tggctctgat agaactgagg cactgaagag     1500

aatggcagat gcactggata actatgttat tcgaggtgtt acacataata ttgcattact     1560

tcgagaggtg ataatcaact cacgctttgt aaaaggagac atcagcacta aatttctctc     1620

cgatgtgtat cctgatggct tcaaaggaca catgctaacc aagagtgaga agaaccagtt     1680

attggcaata gcatcatcat tgtttgtggc attccagtta agagcacaac attttcaaga     1740

aaattcaaga atgcctgtta ttaaaccaga catagccaac tgggagctct cagtaaaatt     1800

gcatgataaa gttcataccg tagtagcatc aaacaatggg tcagtgttct cggtggaagt     1860

tgatgggtcg aaactaaatg tgaccagcac gtggaacctg gcttcgccct tattgtctgt     1920

cagcgttgat ggcactcaga ggactgtcca gtgtctttct cgagaagcag gtggaaacat     1980

gagcattcag tttcttggta cagtgtacaa ggtgaatatc ttaaccagac ttgccgcaga     2040

attgaacaaa tttatgctgg aaaaagtgac tgaggacaca agcagtgttc tgcgttcccc     2100

gatgcccgga gtggtggtgg ccgtctctgt caagcctgga gacgcggtag cagaaggtca     2160

agaaatttgt gtgattgaag ccatgaaaat gcagaatagt atgacagctg ggaaaactgg     2220

cacggtgaaa tctgtgcact gtcaagctgg agacacagtt ggagaagggg atctgctcgt     2280

ggagctggaa tgaaggattt ataacctttc agtcatcacc caatttaatt agccatttgc     2340

atgatgcttt cacacacaat tgattcaagc attatacagg aacacccctg tgcagctacg     2400

tttacgtcgt catttattcc acagagtcaa gaccaatatt ctgccaaaaa atcaccaatg     2460

gaaattttca ttgatataaa tacttgtaca tatgatttgt acttctgctg tgagattccc     2520

tagtgtcaaa attaaatcaa taaaactgag catttgtcta aataaaaaaa aaaaaaa        2577


<210>  853
<211>  728
<212>  PRT
<213>  Homo Sapiens

<400>  853

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp 
    50                  55                  60                  


Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg 
65                  70                  75                  80  


Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val 
                85                  90                  95      


Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val 
            100                 105                 110         


Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met 
        115                 120                 125             


Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly 
    130                 135                 140                 


Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp 
145                 150                 155                 160 


Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp 
                165                 170                 175     


Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile 
            180                 185                 190         


Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile 
        195                 200                 205             


Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly 
    210                 215                 220                 


Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp 
225                 230                 235                 240 


Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp 
                245                 250                 255     


Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile 
            260                 265                 270         


Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg 
        275                 280                 285             


Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro 
    290                 295                 300                 


Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala 
305                 310                 315                 320 


Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu 
                325                 330                 335     


Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr 
            340                 345                 350         


Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp 
        355                 360                 365             


Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His 
    370                 375                 380                 


Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val 
385                 390                 395                 400 


Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg 
                405                 410                 415     


Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp 
            420                 425                 430         


Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met 
        435                 440                 445             


Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys 
    450                 455                 460                 


Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His 
465                 470                 475                 480 


Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys 
                485                 490                 495     


Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe 
            500                 505                 510         


Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile 
        515                 520                 525             


Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln 
    530                 535                 540                 


Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu 
545                 550                 555                 560 


Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn 
                565                 570                 575     


Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val 
            580                 585                 590         


Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp 
        595                 600                 605             


Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn 
    610                 615                 620                 


Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr 
625                 630                 635                 640 


Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu 
                645                 650                 655     


Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala 
            660                 665                 670         


Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys 
        675                 680                 685             


Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr 
    690                 695                 700                 


Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu 
705                 710                 715                 720 


Gly Asp Leu Leu Val Glu Leu Glu 
                725             


<210>  854
<211>  1374
<212>  DNA
<213>  Homo Sapiens

<400>  854
ataagaggtt gggctttgga tagatagaca gactcctggg tccggtcaac cgtcaaaatg       60

tccaaagaac ctctcattct ctggctgatg attgagtttt ggtggcttta cctgacacca      120

gtcacttcag agactgttgt gacggaggtt ttgggtcacc gggtgacttt gccctgtctg      180

tactcatcct ggtctcacaa cagcaacagc atgtgctggg ggaaagacca gtgcccctac      240

tccggttgca aggaggcgct catccgcact gatggaatga gggtgacctc aagaaagtca      300

gcaaaatata gacttcaggg gactatcccg agaggtgatg tctccttgac catcttaaac      360

cccagtgaaa gtgacagcgg tgtgtactgc tgccgcatag aagtgcctgg ctggttcaac      420

gatgtaaaga taaacgtgcg cctgaatcta cagagagcct caacaaccac gcacagaaca      480

gcaaccacca ccacacgcag aacaacaaca acaagcccca ccaccacccg acaaatgaca      540

acaaccccag ctgcacttcc aacaacagtc gtgaccacac ccgatctcac aaccggaaca      600

ccactccaga tgacaaccat tgccgtcttc acaacagcaa acacgtgcct ttcactaacc      660

ccaagcaccc ttccggagga agccacaggt cttctgactc ccgagccttc taaggaaggg      720

cccatcctca ctgcagaatc agaaactgtc ctccccagtg attcctggag tagtgttgag      780

tctacttctg ctgacactgt cctgctgaca tccaaagagt ccaaagtttg ggatctccca      840

tcaacatccc acgtgtcaat gtggaaaacg agtgattctg tgtcttctcc tcagcctgga      900

gcatctgata cagcagttcc tgagcagaac aaaacaacaa aaacaggaca gatggatgga      960

atacccatgt caatgaagaa tgaaatgccc atctcccaac tactgatgat catcgccccc     1020

tccttgggat ttgtgctctt cgcattgttt gtggcgtttc tcctgagagg gaaactcatg     1080

gaaacctatt gttcgcagaa acacacaagg ctagactaca ttggagatag taaaaatgtc     1140

ctcaatgacg tgcagcatgg aagggaagac gaagacggcc tttttaccct ctaacaacgc     1200

agtagcatgt tagattgagg atgggggcat gacactccag tgtcaaaata agtcttagta     1260

gatttccttg tttcataaaa aagactcact tattccatgg atgtcattga tccaggcttg     1320

ctttagtttc atgaatgaag ggtactttag agaccacaac ttctctgtca aaaa           1374


<210>  855
<211>  378
<212>  PRT
<213>  Homo Sapiens

<400>  855

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  856
<211>  2082
<212>  DNA
<213>  Homo Sapiens

<400>  856
accacacaga cacacacctc cttgctggag cattcactag gcgaggcgct ccatcggact       60

cactagccgc actcatgaat cggcaccatc tgcaggatca ctttctggaa atagacaaga      120

agaactgctg tgtgttccga gatgacttca ttgtcaaggt gttgccgccg gtgttggggc      180

tggagtttat cttcgggctt ctgggcaatg gccttgccct gtggattttc tgtttccacc      240

tcaagtcctg gaaatccagc cggattttcc tgttcaacct ggcagtggct gactttctac      300

tgatcatctg cctgcccttc ctgatggaca actatgtgag gcgttgggac tggaagtttg      360

gggacatccc ttgccggctg atgctcttca tgttggctat gaaccgccag ggcagcatca      420

tcttcctcac ggtggtggcg gtagacaggt atttccgggt ggtccatccc caccacgccc      480

tgaacaagat ctccaatcgg acagcagcca tcatctcttg ccttctgtgg ggcatcacta      540

ttggcctgac agtccacctc ctgaagaaga agatgccgat ccagaatggc ggtgcaaatt      600

tgtgcagcag cttcagcatc tgccatacct tccagtggca cgaagccatg ttcctcctgg      660

agttcttcct gcccctgggc atcatcctgt tctgctcagc cagaattatc tggagcctgc      720

ggcagagaca aatggaccgg catgccaaga tcaagagagc catcaccttc atcatggtgg      780

tggccatcgt ctttgtcatc tgcttccttc ccagcgtggt tgtgcggatc cgcatcttct      840

ggctcctgca cacttcgggc acgcagaatt gtgaagtgta ccgctcggtg gacctggcgt      900

tctttatcac tctcagcttc acctacatga acagcatgct ggaccccgtg gtgtactact      960

tctccagccc atcctttccc aacttcttct ccactttgat caaccgctgc ctccagagga     1020

agatgacagg tgagccagat aataaccgca gcacgagcgt cgagctcaca ggggacccca     1080

acaaaaccag aggcgctcca gaggcgttaa tggccaactc cggtgagcca tggagcccct     1140

cttatctggg cccaacctct ccttaaataa ccatgccaag aagggacatt gtcaccaaga     1200

accaggatct ctggagaaac agttgggctg ttgcatcgag taatgtcact ggactcggcc     1260

taaggtttcc tggaacttcc agattcagag aatgcgattt agggaaacgg tggcagatga     1320

gtgggagact ggttgcaagg tgtgaccgca ggaatcctgg aggaatagag agtaaagctt     1380

ctaggcatct gaaacttttg cttcatctct gacgctcgca ggactgaaga tgggcaaatt     1440

gtaggcattt ctgctgagca gagttggagc cagagatcta cttgtgactt gttggccttc     1500

ttcccacatc tgcctcagac tggagggggc tcagctcctg gggtgatatc tagcctgctt     1560

gtgagctcta gcagggataa ggagagctga gattggaggg aattgtgttg ctcctggagg     1620

gagcccaggc atcattaaac aagccagtag gtcacctggc ttccgtggac caattcatct     1680

ttcagacaag ctttagcaga aatggactca gggaagagac tcacacgctt tggttaatat     1740

ctgtgtttcc ggtgggtgta ataggggatt agccccagaa gggactgagc taaacagtgt     1800

tattatggga aaggaaatgg cattgctgct ttcaaccagc gactaatgca atccattcct     1860

ctcttgttta tagtaatcta agggttgggc agttaaaacg gcttcaggat agaaagctgt     1920

ttcccacctc tgtttgcttt taacattaaa agggaaatgt gcctctgccc cacagttaga     1980

ggggtgcacg ttcctcctgg ttccttcgct tgtgtttctg tacttaccaa aaatctacca     2040

tttcaataaa ttttgatagg agacaaaaaa aaaaaaaaaa aa                        2082


<210>  857
<211>  363
<212>  PRT
<213>  Homo Sapiens

<400>  857

Met Asn Arg His His Leu Gln Asp His Phe Leu Glu Ile Asp Lys Lys 
1               5                   10                  15      


Asn Cys Cys Val Phe Arg Asp Asp Phe Ile Val Lys Val Leu Pro Pro 
            20                  25                  30          


Val Leu Gly Leu Glu Phe Ile Phe Gly Leu Leu Gly Asn Gly Leu Ala 
        35                  40                  45              


Leu Trp Ile Phe Cys Phe His Leu Lys Ser Trp Lys Ser Ser Arg Ile 
    50                  55                  60                  


Phe Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu Ile Ile Cys Leu 
65                  70                  75                  80  


Pro Phe Leu Met Asp Asn Tyr Val Arg Arg Trp Asp Trp Lys Phe Gly 
                85                  90                  95      


Asp Ile Pro Cys Arg Leu Met Leu Phe Met Leu Ala Met Asn Arg Gln 
            100                 105                 110         


Gly Ser Ile Ile Phe Leu Thr Val Val Ala Val Asp Arg Tyr Phe Arg 
        115                 120                 125             


Val Val His Pro His His Ala Leu Asn Lys Ile Ser Asn Arg Thr Ala 
    130                 135                 140                 


Ala Ile Ile Ser Cys Leu Leu Trp Gly Ile Thr Ile Gly Leu Thr Val 
145                 150                 155                 160 


His Leu Leu Lys Lys Lys Met Pro Ile Gln Asn Gly Gly Ala Asn Leu 
                165                 170                 175     


Cys Ser Ser Phe Ser Ile Cys His Thr Phe Gln Trp His Glu Ala Met 
            180                 185                 190         


Phe Leu Leu Glu Phe Phe Leu Pro Leu Gly Ile Ile Leu Phe Cys Ser 
        195                 200                 205             


Ala Arg Ile Ile Trp Ser Leu Arg Gln Arg Gln Met Asp Arg His Ala 
    210                 215                 220                 


Lys Ile Lys Arg Ala Ile Thr Phe Ile Met Val Val Ala Ile Val Phe 
225                 230                 235                 240 


Val Ile Cys Phe Leu Pro Ser Val Val Val Arg Ile Arg Ile Phe Trp 
                245                 250                 255     


Leu Leu His Thr Ser Gly Thr Gln Asn Cys Glu Val Tyr Arg Ser Val 
            260                 265                 270         


Asp Leu Ala Phe Phe Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
        275                 280                 285             


Leu Asp Pro Val Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Asn Phe 
    290                 295                 300                 


Phe Ser Thr Leu Ile Asn Arg Cys Leu Gln Arg Lys Met Thr Gly Glu 
305                 310                 315                 320 


Pro Asp Asn Asn Arg Ser Thr Ser Val Glu Leu Thr Gly Asp Pro Asn 
                325                 330                 335     


Lys Thr Arg Gly Ala Pro Glu Ala Leu Met Ala Asn Ser Gly Glu Pro 
            340                 345                 350         


Trp Ser Pro Ser Tyr Leu Gly Pro Thr Ser Pro 
        355                 360             


<210>  858
<211>  4563
<212>  DNA
<213>  Homo Sapiens

<400>  858
gggcggggac gccgcggcag gaaggccatg gcggggcccg agcgctgggg ccccctgctc       60

ctgtgcctgc tgcaggccgc tccagggagg ccccgtctgg cccctcccca gaatgtgacg      120

ctgctctccc agaacttcag cgtgtacctg acatggctcc cagggcttgg caacccccag      180

gatgtgacct attttgtggc ctatcagagc tctcccaccc gtagacggtg gcgcgaagtg      240

gaagagtgtg cgggaaccaa ggagctgcta tgttctatga tgtgcctgaa gaaacaggac      300

ctgtacaaca agttcaaggg acgcgtgcgg acggtttctc ccagctccaa gtccccctgg      360

gtggagtccg aatacctgga ttaccttttt gaagtggagc cggccccacc tgtcctggtg      420

ctcacccaga cggaggagat cctgagtgcc aatgccacgt accagctgcc cccctgcatg      480

cccccactgg atctgaagta tgaggtggca ttctggaagg agggggccgg aaacaagacc      540

ctatttccag tcactcccca tggccagcca gtccagatca ctctccagcc agctgccagc      600

gaacaccact gcctcagtgc cagaaccatc tacacgttca gtgtcccgaa atacagcaag      660

ttctctaagc ccacctgctt cttgctggag gtcccagaag ccaactgggc tttcctggtg      720

ctgccatcgc ttctgatact gctgttagta attgccgcag ggggtgtgat ctggaagacc      780

ctcatgggga acccctggtt tcagcgggca aagatgccac gggccctgga cttttctgga      840

cacacacacc ctgtggcaac ctttcagccc agcagaccag agtccgtgaa tgacttgttc      900

ctctgtcccc aaaaggaact gaccagaggg gtcaggccga cgcctcgagt cagggcccca      960

gccacccaac agacaagatg gaagaaggac cttgcagagg acgaagagga ggaggatgag     1020

gaggacacag aagatggcgt cagcttccag ccctacattg aaccaccttc tttcctgggg     1080

caagagcacc aggctccagg gcactcggag gctggtgggg tggactcagg gaggcccagg     1140

gctcctctgg tcccaagcga aggctcctct gcttgggatt cttcagacag aagctgggcc     1200

agcactgtgg actcctcctg ggacagggct gggtcctctg gctatttggc tgagaagggg     1260

ccaggccaag ggccgggtgg ggatgggcac caagaatctc tcccaccacc tgaattctcc     1320

aaggactcgg gtttcctgga agagctccca gaagataacc tctcctcctg ggccacctgg     1380

ggcaccttac caccggagcc gaatctggtc cctgggggac ccccagtttc tcttcagaca     1440

ctgaccttct gctgggaaag cagccctgag gaggaagagg aggcgaggga atcagaaatt     1500

gaggacagcg atgcgggcag ctggggggct gagagcaccc agaggaccga ggacaggggc     1560

cggacattgg ggcattacat ggccaggtga gctgtccccc gacatcccac cgaatctgat     1620

gctgctgctg cctttgcaag gactactggg cttcccaaga aactcaagag cctccgtacc     1680

tcccctgggc ggcggagggg cattgcactt ccgggaagtc cacctagcgg ctgtttgcct     1740

gtcgggctga gcaacaagat gcccctccct cctgtgaccc gccctcttta ggctgagcta     1800

taagaggggt ggacacaggg tgggctgagg tcagaggttg gtggggtgtc atcaccccca     1860

ttgtccctag ggtgacaggc cagggggaaa aattatcccc ggacaacatg aaacaggtga     1920

ggtcaggtca ctgcggacat caagggcgga caccaccaag gggccctctg gaacttgaga     1980

ccactggagg cacacctgct atacctcatg cctttcccag cagccactga actcccccat     2040

cccagggctc agcctcctga ttcatgggtc ccctagttag gcccagataa aaatccagtt     2100

ggctgagggt tttggatggg aagggaaggg tggctgtcct caaatcctgg tctttggagt     2160

catggcactg tacggtttta gtgtcagaca gaccggggtt caaatcccag ctctgctgtt     2220

cactggttgt atgatcttgg ggaagacatc ttccttctct gcctcggctt cctcatctgc     2280

agctacgcct gggtgtggtg agggttctag gggatctcag atgtgtgtag cacggagcct     2340

gctgtgtcct gggtgctctc tacgtggtgg ccggtagaat tctccatcta tccaggctcc     2400

aggagacccc tgggcatctc ccacctgtgg cccctaaacc cagagtgact gagagcactt     2460

aacattcagc ttgtctcatc cccagtctac ctccttcctt ctaccctcac tgcctcccag     2520

tcaggagagt gagctctcag aagccagagc cccacccaag gggaccctgg tctctccgcc     2580

ttcacctagc aatgggaacc ctgcttccca ggggaggaac caactgctcc accttctagg     2640

gacccagttt gttggagtag gacagtaaca tggcaggaat cggacttctg ggcctgtaat     2700

cccagtttgg atggcacgtt agactcttgg ttgaccgttg tggtccttag aagtcccatt     2760

ctcccttcca gttatgagaa accaatgcct tctagattca ggtgactatc cttacctggg     2820

ggtgctgatg catcctcagt taacctacac ccacctgaat atagatgagc gtagctgagt     2880

tttcacccgt aggaccgaag tgttttgtgg tggagtatct gaacaacctt ggctctgtgg     2940

ccattcaacc tgccaggact aacatttctg gatttgtgaa gaagggatct tcaaagccat     3000

tgaacccaca gagctgtgtt gctttaaagc caccacaagg gtacagcatt aaatggcaga     3060

actggaaaag cttcttaggg catctcatcc agggattctc aaaccatgtc ccccagaggc     3120

cttgggctgc agttgcaggg ggcgccatgg ggctatagga gcctcccact ttcaccagag     3180

cagcctcact gtgccctgat tcacacactg tggctttcca cgtgaggttt tgtttagagg     3240

gatccactac tcaagaaaaa gttagcaaac cactcctttt gttgcaaagg agctgaggtc     3300

aagggtggca aaggcacttg tccaaggtcg cccagcagtg ctgctctgat gacttgtgca     3360

catccccaag ggtaagagct tcgatctctg cacagccggg ccaacctctg accccttgtc     3420

catgtcagta aaatatgaag gtcacagcca ggatttctaa gggtcaggag gccttcaccg     3480

ctgctggggc acacacacac acatgcatac acacatacga cacacacctg tgtctcccca     3540

ggggttttcc ctgcagtgag gcttgtccag atgattgagc ccaggagagg aagaacaaac     3600

aaactacgga gctggggagg gctgtggctt ggggccagct cccagggaaa ttcccagacc     3660

tgtaccgatg ttctctctgg caccagccga gctgcttcgt ggaggtaact tcaaaaaagt     3720

aaaagctatc atcagcatca tcttagactt gtatgaaata accactccgt ttctattctt     3780

aaaccttacc atttttgttt tgttttgttt ttttgagtcg gagttttgtt ctttttgcct     3840

aggctggagt gcagtggtac aatctcggct cactgcaacc tccacctccc gggttcaagt     3900

gattctcctg cctcagcctc ccaagtagct gggattacag gcacccgcca ccacacctgg     3960

ctaatttttt tgtattttta gtagagacgg ggtttcacca tgttggccag gctggtctcg     4020

aactcctgac ctcaggtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg     4080

tgagccaccg cgcccagcca aaccttacta tttttttaaa gaattttttc cagagtttaa     4140

tttctgacat agcttaagtt ttccagtaac tctaaactcc atctccttta tcgtcattaa     4200

gtcattcaca aaaagccagg agaagcattt ggaaagggca tgataatcag tataataatt     4260

tgccttgtgt ggtcagcact taactgttta caaagccctt tcacgtgcac agcaggtggg     4320

aactgcgcgg tgtgggctgg gcctgcgctg gaagcatatc ccgtgaaaag tgttagtgcc     4380

ttaggtgaaa gcaacatgta tccctttaga ctactaacgg tatatgttgt tcttatgtat     4440

ttgtatttat ttctattttt tctatgttta tgtcatattt aaacgatatc ctactgcttg     4500

ttggtattac cctaaactgt ttaaataaag agctctattt ttaaagaaaa aaggtacaat     4560

tga                                                                   4563


<210>  859
<211>  520
<212>  PRT
<213>  Homo Sapiens

<400>  859

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210>  860
<211>  3301
<212>  DNA
<213>  Homo Sapiens

<400>  860
gtgcctcttg cagcagccta acccagaagc aggggggaat cctgaatcga gctgagaggg       60

cttccccggt tctcctggga accccatcgg ccccctgcca gcacacacct gagcagcatc      120

acaggacatg gccccctcag ccacctagct ggggcccatc taggagtggc atcttttttg      180

gtgccctgaa ggccagctct ggaccttccc aggaaaagtg ccagctcaca gaactgcttg      240

accaaaggac cggctcttga gacatccccc aacccacctg gcccccagct agggtggggg      300

ctccaggaga ctgagattag cctgccctct ttggacagca gctccaggac agggcgggtg      360

ggctgaccac ccaaacccca tctgggccca ggccccatgc cccgaggagg ggtggtctga      420

agcccaccag agccccctgc cagactgtct gcctcccttc tgactgtggc cgcttggcat      480

ggccagcaac agcagctcct gcccgacacc tgggggcggg cacctcaatg ggtacccggt      540

gcctccctac gccttcttct tcccccctat gctgggtgga ctctccccgc caggcgctct      600

gaccactctc cagcaccagc ttccagttag tggatatagc acaccatccc cagccaccat      660

tgagacccag agcagcagtt ctgaagagat agtgcccagc cctccctcgc caccccctct      720

accccgcatc tacaagcctt gctttgtctg tcaggacaag tcctcaggct accactatgg      780

ggtcagcgcc tgtgagggct gcaagggctt cttccgccgc agcatccaga agaacatggt      840

gtacacgtgt caccgggaca agaactgcat catcaacaag gtgacccgga accgctgcca      900

gtactgccga ctgcagaagt gctttgaagt gggcatgtcc aaggagtctg tgagaaacga      960

ccgaaacaag aagaagaagg aggtgcccaa gcccgagtgc tctgagagct acacgctgac     1020

gccggaggtg ggggagctca ttgagaaggt gcgcaaagcg caccaggaaa ccttccctgc     1080

cctctgccag ctgggcaaat acactacgaa caacagctca gaacaacgtg tctctctgga     1140

cattgacctc tgggacaagt tcagtgaact ctccaccaag tgcatcatta agactgtgga     1200

gttcgccaag cagctgcccg gcttcaccac cctcaccatc gccgaccaga tcaccctcct     1260

caaggctgcc tgcctggaca tcctgatcct gcggatctgc acgcggtaca cgcccgagca     1320

ggacaccatg accttctcgg acgggctgac cctgaaccgg acccagatgc acaacgctgg     1380

cttcggcccc ctcaccgacc tggtctttgc cttcgccaac cagctgctgc ccctggagat     1440

ggatgatgcg gagacggggc tgctcagcgc catctgcctc atctgcggag accgccagga     1500

cctggagcag ccggaccggg tggacatgct gcaggagccg ctgctggagg cgctaaaggt     1560

ctacgtgcgg aagcggaggc ccagccgccc ccacatgttc cccaagatgc taatgaagat     1620

tactgacctg cgaagcatca gcgccaaggg ggctgagcgg gtgatcacgc tgaagatgga     1680

gatcccgggc tccatgccgc ctctcatcca ggaaatgttg gagaactcag agggcctgga     1740

cactctgagc ggacagccgg ggggtggggg gcgggacggg ggtggcctgg cccccccgcc     1800

aggcagctgt agccccagcc tcagccccag ctccaacaga agcagcccgg ccacccactc     1860

cccgtgaccg cccacgccac atggacacag ccctcgccct ccgccccggc ttttctctgc     1920

ctttctaccg accatgtgac cccgcaccag ccctgccccc acctgccctc ccgggcagta     1980

ctggggacct tccctggggg acggggaggg aggaggcagc gactccttgg acagaggcct     2040

gggccctcag tggactgcct gctcccacag cctgggctga cgtcagaggc cgaggccagg     2100

aactgagtga ggcccctggt cctgggtctc aggatgggtc ctgggggcct cgtgttcatc     2160

aagacacccc tctgcccagc tcaccacatc ttcatcacca gcaaacgcca ggacttggct     2220

cccccatcct cagaactcac aagccattgc tccccagctg gggaacctca acctcccccc     2280

tgcctcggtt ggtgacagag ggggtgggac aggggcgggg ggttccccct gtacataccc     2340

tgccatacca accccaggta ttaattctcg ctggttttgt ttttatttta atttttttgt     2400

tttgattttt ttaataagaa ttttcatttt aagcacattt atactgaagg aatttgtgct     2460

gtgtattggg gggagctgga tccagagctg gagggggtgg gtccggggga gggagtggct     2520

cggaaggggc ccccactctc ctttcatgtc cctgtgcccc ccagttctcc tcctcagcct     2580

tttcctcctc agttttctct ttaaaactgt gaagtactaa ctttccaagg cctgccttcc     2640

cctccctccc actggagaag ccgccagccc ctttctccct ctgcctgacc actgggtgtg     2700

gacggtgtgg ggcagccctg aaaggacagg ctcctggcct tggcacttgc ctgcacccac     2760

catgaggcat ggagcagggc agagcaaggg ccccgggaca gagttttccc agacctggct     2820

cctcggcaga gctgcctccc gtcagggccc acatcatcta ggctccccag cccccactgt     2880

gaaggggctg gccaggggcc cgagctgccc ccacccccgg cctcagccac cagcaccccc     2940

atagggcccc cagacaccac acacatgcgc gtgcgcacac acacaaacac acacacactg     3000

gacagtagat gggccgacac acacttggcc cgagttcctc catttccctg gcctgccccc     3060

cacccccaac ctgtcccacc cccgtgcccc ctccttaccc cgcaggacgg gcctacaggg     3120

gggtctcccc tcacccctgc acccccagct gggggagctg gctctgcccc gacctccttc     3180

accaggggtt ggggcccctt cccctggagc ccgtgggtgc acctgttact gttgggcttt     3240

ccactgagat ctactggata aagaataaag ttctatttat tctaaaaaaa aaaaaaaaaa     3300

a                                                                     3301


<210>  861
<211>  462
<212>  PRT
<213>  Homo Sapiens

<400>  861

Met Ala Ser Asn Ser Ser Ser Cys Pro Thr Pro Gly Gly Gly His Leu 
1               5                   10                  15      


Asn Gly Tyr Pro Val Pro Pro Tyr Ala Phe Phe Phe Pro Pro Met Leu 
            20                  25                  30          


Gly Gly Leu Ser Pro Pro Gly Ala Leu Thr Thr Leu Gln His Gln Leu 
        35                  40                  45              


Pro Val Ser Gly Tyr Ser Thr Pro Ser Pro Ala Thr Ile Glu Thr Gln 
    50                  55                  60                  


Ser Ser Ser Ser Glu Glu Ile Val Pro Ser Pro Pro Ser Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Arg Ile Tyr Lys Pro Cys Phe Val Cys Gln Asp Lys Ser Ser 
                85                  90                  95      


Gly Tyr His Tyr Gly Val Ser Ala Cys Glu Gly Cys Lys Gly Phe Phe 
            100                 105                 110         


Arg Arg Ser Ile Gln Lys Asn Met Val Tyr Thr Cys His Arg Asp Lys 
        115                 120                 125             


Asn Cys Ile Ile Asn Lys Val Thr Arg Asn Arg Cys Gln Tyr Cys Arg 
    130                 135                 140                 


Leu Gln Lys Cys Phe Glu Val Gly Met Ser Lys Glu Ser Val Arg Asn 
145                 150                 155                 160 


Asp Arg Asn Lys Lys Lys Lys Glu Val Pro Lys Pro Glu Cys Ser Glu 
                165                 170                 175     


Ser Tyr Thr Leu Thr Pro Glu Val Gly Glu Leu Ile Glu Lys Val Arg 
            180                 185                 190         


Lys Ala His Gln Glu Thr Phe Pro Ala Leu Cys Gln Leu Gly Lys Tyr 
        195                 200                 205             


Thr Thr Asn Asn Ser Ser Glu Gln Arg Val Ser Leu Asp Ile Asp Leu 
    210                 215                 220                 


Trp Asp Lys Phe Ser Glu Leu Ser Thr Lys Cys Ile Ile Lys Thr Val 
225                 230                 235                 240 


Glu Phe Ala Lys Gln Leu Pro Gly Phe Thr Thr Leu Thr Ile Ala Asp 
                245                 250                 255     


Gln Ile Thr Leu Leu Lys Ala Ala Cys Leu Asp Ile Leu Ile Leu Arg 
            260                 265                 270         


Ile Cys Thr Arg Tyr Thr Pro Glu Gln Asp Thr Met Thr Phe Ser Asp 
        275                 280                 285             


Gly Leu Thr Leu Asn Arg Thr Gln Met His Asn Ala Gly Phe Gly Pro 
    290                 295                 300                 


Leu Thr Asp Leu Val Phe Ala Phe Ala Asn Gln Leu Leu Pro Leu Glu 
305                 310                 315                 320 


Met Asp Asp Ala Glu Thr Gly Leu Leu Ser Ala Ile Cys Leu Ile Cys 
                325                 330                 335     


Gly Asp Arg Gln Asp Leu Glu Gln Pro Asp Arg Val Asp Met Leu Gln 
            340                 345                 350         


Glu Pro Leu Leu Glu Ala Leu Lys Val Tyr Val Arg Lys Arg Arg Pro 
        355                 360                 365             


Ser Arg Pro His Met Phe Pro Lys Met Leu Met Lys Ile Thr Asp Leu 
    370                 375                 380                 


Arg Ser Ile Ser Ala Lys Gly Ala Glu Arg Val Ile Thr Leu Lys Met 
385                 390                 395                 400 


Glu Ile Pro Gly Ser Met Pro Pro Leu Ile Gln Glu Met Leu Glu Asn 
                405                 410                 415     


Ser Glu Gly Leu Asp Thr Leu Ser Gly Gln Pro Gly Gly Gly Gly Arg 
            420                 425                 430         


Asp Gly Gly Gly Leu Ala Pro Pro Pro Gly Ser Cys Ser Pro Ser Leu 
        435                 440                 445             


Ser Pro Ser Ser Asn Arg Ser Ser Pro Ala Thr His Ser Pro 
    450                 455                 460         


<210>  862
<211>  5351
<212>  DNA
<213>  Homo Sapiens

<400>  862
gcgattcggc tggctctgcc acaccaccgc gcgcccccgc tccgcccgcc cctccgggcg       60

cgtcttttcc gggctcgcgc tgagtcccgc ctccgccggc tgtccgggtg cgcgcgcgcc      120

gctgcggctt tttctctggc ctccgccgcg cgctcctcct cgtcccagcg ctagcgggca      180

cgcggttcct ttttgcgagc tttccgagtg ccaggcgccg gccggctgcg aagacgcggt      240

gggccgcccc tccgattgaa atcacagaag atattcgtgt tcttcttaag agaaaaagag      300

gacattttag ctttctcagt tgaaggcgta ctttattgtc ggcttccaaa gattactaac      360

ttttatctgt atcactaaga ttgaactgcc ttggctgtac tgctattctt actgctgctt      420

ctattattgc cttcttcagc acaataaggc tttcaaaagc caaagaataa caagaaataa      480

gcaccatttt agaagccttt ccactatgaa acttaagcta aatgtgctca ccattatttt      540

gctgcctgtc cacttgttaa taacaatata cagtgccctt atatttattc catggtattt      600

tcttaccaat gccaagaaga aaaacgctat ggcaaagaga ataaaagcta agcccacttc      660

agacaaacct ggaagtccat atcgctctgt cacacacttc gactcactag ctgtaataga      720

catccctgga gcagatactc tggataaatt atttgaccat gctgtatcca agtttgggaa      780

gaaggacagc cttgggacca gggaaatcct aagtgaagaa aatgaaatgc agccaaatgg      840

aaaagttttt aagaagttaa ttcttgggaa ttataaatgg atgaactatc ttgaagtgaa      900

tcgcagagtg aataactttg gtagtggact cactgcactg ggactaaaac caaagaacac      960

cattgccatc ttctgtgaga ccagggccga atggatgatt gcagcacaga cctgctttaa     1020

gtacaacttt cctcttgtga ctttatatgc cacacttggc aaagaagcag tagttcatgg     1080

gctaaatgaa tctgaggctt cctatctgat taccagtgtt gaacttctgg aaagtaaact     1140

taagactgca ttgttagata tcagttgtgt taaacatatc atttatgtgg acaataaggc     1200

tatcaataaa gcagagtacc ctgaaggatt tgagattcac agcatgcaat cagtagaaga     1260

gttgggatct aacccagaaa acttgggcat tcctccaagt agaccaacgc cttcagacat     1320

ggccattgtt atgtatacta gtggttctac tggccgacct aagggagtga tgatgcatca     1380

tagcaatttg atagctggaa tgacaggcca gtgtgaaaga atacctggac tgggaccgaa     1440

ggacacatat attggctact tgcctttggc tcatgtgcta gaactgacag cagagatatc     1500

ttgctttacc tatggctgca ggattggata ttcttctccg cttacactct ctgaccagtc     1560

cagcaaaatt aaaaaaggaa gcaaaggaga ctgtactgta ctgaagccca cacttatggc     1620

tgctgttccg gaaatcatgg atagaattta taagaatgtt atgagcaaag tccaagagat     1680

gaattatatt cagaaaactc tgttcaagat agggtatgat tacaaattgg aacagatcaa     1740

aaagggatat gatgcacctc tttgcaatct gttactgttt aaaaaggtca aggccctgct     1800

gggagggaat gtccgcatga tgctgtctgg aggggccccg ctatctcctc agacacaccg     1860

attcatgaat gtctgcttct gctgcccaat tggccagggt tatggactga cagaatcatg     1920

tggtgctggg acagttactg aagtaactga ctatactact ggcagagttg gagcacctct     1980

tatttgctgt gaaattaagc taaaagactg gcaagaaggc ggttatacaa ttaatgacaa     2040

gccaaacccc agaggtgaaa tcgtaattgg tggacagaac atctccatgg gatattttaa     2100

aaatgaagag aaaacagcag aagattattc tgtggatgaa aatggacaaa ggtggttttg     2160

cactggtgat attggagaat tccatcccga tggatgttta cagattatag atcgtaagaa     2220

agatctagtg aagttacaag caggagagta tgtatctctt gggaaagtag aagctgcact     2280

gaagaattgt ccacttattg acaacatctg tgcttttgcc aaaagtgatc agtcctatgt     2340

gatcagtttt gtggttccta accagaaaag gttgacactt ttggcacaac agaaaggggt     2400

agaaggaact tgggttgata tctgcaataa tcctgctatg gaagctgaaa tactgaaaga     2460

aattcgagaa gctgcaaatg ccatgaaatt ggagcgattt gaaattccaa tcaaggttcg     2520

attaagccca gagccatgga cccctgaaac tggtttggta actgatgctt tcaaactgaa     2580

aaggaaggag ctgaggaacc attacctcaa agacattgaa cgaatgtatg ggggcaaata     2640

aaatgttgtt gtcttattga cagttgtgca ggaggtagcc tggtggtttt caacctctag     2700

aattttaagc ctttgttgaa ctgttagaat gtaaggtata tcattctaaa gatagagtaa     2760

aaagaaaaca aaaccaaaag ttattaaaat tgttgtccgg tttactttaa cttagttttg     2820

catagttcta gtgcagctga aattgaaaag ttatttccct ttagctgtgt tattatagag     2880

cagaaattct gtttttaaaa attagcctaa gatatacttg tttttgtaaa gaaaaatatt     2940

taatgttgaa caaaataaat tggagttgga gtagaatgta gtttgaggaa atttgcagct     3000

tccaatgcct cttgtcttcc tatttcagaa gtttaaatat taagcatgac agaaaatatg     3060

tattaacact actcaaagca aaagtgctgc agggctttaa aattctcttc caaccattta     3120

tcttgaagga aaaattcaat agtaatataa tacacaaaat caaataatac cttagaaggt     3180

attaagatta taattgttgc ataggttaga tatagagtca ttgtaatgtt gtgaataatt     3240

acagtgccta aaataagaat agaacaacat atacaacacc aaaaaatatc tagtaatata     3300

tttaaaggga aattgagctg ctttttttga aactttgaga tctaaaaata actgtaatta     3360

tttgaatgac taagaggaaa gtacattttt tgaaatgctg aaaattgcct ttctgtgttt     3420

attcaaactg aaaagctgag accaagagca aggaaggtaa aaagttaaca ggcaaacatt     3480

ttctcttaga aaaggtgata aaatcataag tatttggaat tagaaccctt gcacagcact     3540

gaacctggga aagagattta aactctgaat ttatctttga taacagggat tgattttaaa     3600

atgtacatgt attaaattac atttgtaatt taaggtctgt ttgctgttgc tgattttatt     3660

cttgatcagt agtttgcatt tcagaaagcc tttcattttg ctttaatttt agcaaagcgg     3720

gttataatga atgacttccc caatatcttg cttgaactta caggtgatta acttggatga     3780

gttttgggaa gttaaaggga agaaaacact gttatcattt tttcctgttt gggaagagct     3840

tagaaactgg aaatactaga tttgggagaa gggcagagtt acttgataag ggactgatgt     3900

ttgtgcagta acttgggagt gtggtttctt tttgaatctt taattaaaac ctgggattat     3960

atatccctga taaatattca cacttgaacc atagttactg taaaatgcaa aaaatcttaa     4020

tactgttatt ctttgcactt tttcttaatc attttttata tatatgcata tatatatgtg     4080

tgtgtgtgtg ttgcttatgt tgttttgtac agatgtgggc caccattgca acaaaataca     4140

ttctttttgc tctaaaatat ttatgaagaa aatacttaaa tgttatgtat atggtggtaa     4200

taagggaaaa atcaagtatt ataaacaaga atgaaggttt ttgtaaagat ttctgttcag     4260

cgttttgcaa ggtaaaattt taggcaagtt ttccctgaag ttatgtgtat gtgagtattc     4320

tcattcttcc caacttgcct ttgaagagtg aaataccatt attatcaagt agactactgt     4380

tcagctttta ttcctgccct gctgtttatc ccttaagaat gagtttctta gacttttcca     4440

atatgtgatt ttttttccca tttagaatgg tgattttaaa tgtgtgagtg catgtactat     4500

cttatctcag atatttgcac ccccaatctg cccccaactc ccaaaagcta gaacactgcc     4560

aactgatctg ttataggtcc tttagaaaca cataattaac acttaaggtt gggtgctgct     4620

aattctttgc aaaaatccaa atattgttaa gggaccaggg agatgccact accccttgat     4680

tttccatcta aaaatataca tgtttatgta aacaaatctt tccatatcca tagtgacttt     4740

tcaagtattt aagcctaaag attttgatct cacattttta tacctgttta aattgctcac     4800

agttattaca tacacatcag ccatcaacta aagttgtact ttaaaaattt actacaatat     4860

gtacatttct aagtcaaaca cttgtgactt ttgctttaat tccatgaatg ttcctgcctc     4920

cttgatattt gtatttattc tttttttctc tagagtagag gtataattgt gtgatatttc     4980

agaaatacag ataaatgatt caaaaagtca cagttaagga gaatcatgtt tctttgatca     5040

tgaataactg attagtaagt cttgcctata ttttcctgat agcatatgac aaatgtttct     5100

aaggtaacaa gatgagaaca gataaagatt gtgtggtgtt ttggatttgg agagaaatat     5160

tttaattttt aaatgcagtt acaaattata atgtattcat atttgtactt tctgttaaaa     5220

tgcatgattg cagaattgtt tagattttgt gtttattctt gatgaaaagc tttgtttgtt     5280

cttgttttta agtttgcact caaatcttaa gaaataaatc cacccatgtt atcaaaaaaa     5340

aaaaaaaaaa a                                                          5351


<210>  863
<211>  711
<212>  PRT
<213>  Homo Sapiens

<400>  863

Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His 
1               5                   10                  15      


Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe 
            20                  25                  30          


Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala 
        35                  40                  45              


Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His 
    50                  55                  60                  


Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp 
65                  70                  75                  80  


Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu 
                85                  90                  95      


Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly 
            100                 105                 110         


Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr 
        115                 120                 125             


Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala 
    130                 135                 140                 


Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg 
145                 150                 155                 160 


Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro 
                165                 170                 175     


Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly 
            180                 185                 190         


Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu 
        195                 200                 205             


Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His 
    210                 215                 220                 


Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu 
225                 230                 235                 240 


Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn 
                245                 250                 255     


Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met 
            260                 265                 270         


Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val 
        275                 280                 285             


Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu 
    290                 295                 300                 


Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro 
305                 310                 315                 320 


Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr 
                325                 330                 335     


Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser 
            340                 345                 350         


Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro 
        355                 360                 365             


Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn 
    370                 375                 380                 


Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe 
385                 390                 395                 400 


Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp 
                405                 410                 415     


Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu 
            420                 425                 430         


Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro 
        435                 440                 445             


Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln 
    450                 455                 460                 


Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val 
465                 470                 475                 480 


Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu 
                485                 490                 495     


Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys 
            500                 505                 510         


Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met 
        515                 520                 525             


Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp 
    530                 535                 540                 


Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His 
545                 550                 555                 560 


Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys 
                565                 570                 575     


Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu 
            580                 585                 590         


Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp 
        595                 600                 605             


Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr 
    610                 615                 620                 


Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys 
625                 630                 635                 640 


Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala 
                645                 650                 655     


Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg 
            660                 665                 670         


Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala 
        675                 680                 685             


Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile 
    690                 695                 700                 


Glu Arg Met Tyr Gly Gly Lys 
705                 710     


<210>  864
<211>  6162
<212>  DNA
<213>  Homo Sapiens

<400>  864
attgatctct gttgccgctc agggaggtca gctccaggcc ctcagccttt cggccgggag       60

ccaaactgcc ctgcctgcca agcccctcct tctctgcacc ttaaacagcc gcgaggggag      120

agtcggctgg gattttcttc ttaagaagtc gcgcaggttt ttcgagctcc actctgcgcc      180

aggagagcca cggcagcagg aacgggcact gctgccaccg ggccgacgga gctgcatcct      240

gtggccctat aacactcttc tccaaaagga cctgccagag actgggagtg ttgactgctg      300

caaggaccaa ggtgggatag taacatcttt ttgagggaag aattggcttc ctttcttgaa      360

agtggtgaag gtacagcata tagctgcatg gaagaaacag taatcggatg gctaccttct      420

acattttgta ttaggaaaca aagtccattg taagagtcca tgttgatctt ggaaatagaa      480

ggattgaaaa aagctaaatt tccacaaaga acaagaactt gaccatctcc tttttgatct      540

gaagactagg ggacaatgga tatcatagag acagcaaaac ttgaagaaca tttggaaaat      600

caacccagtg atcctacgaa cacttatgca agacccgctg aacctgttga agaagaaaac      660

aaaaatggca atggtaaacc caagagctta tccagtgggc tgcgaaaagg caccaaaaag      720

tacccggact atatccaaat tgctatgccc actgaatcaa ggaacaaatt tccactagag      780

tggtggaaaa cgggcattgc cttcatatat gcagttttca acctcgtctt gacaaccgtc      840

atgatcacag ttgtacatga gagggtccct cccaaggagc ttagccctcc actcccagac      900

aagttttttg attacattga tagggtgaaa tgggcatttt ctgtatcaga aataaatggg      960

attatattag ttggattatg gatcacccag tggctgtttc tgagatacaa gtcaatagtg     1020

ggacgcagat tctgttttat tattggaact ttatacctgt atcgctgcat tacaatgtat     1080

gttactactc tacctgtgcc tggaatgcat ttccagtgtg ctccaaagct caatggagac     1140

tctcaggcaa aagttcaacg gattctacga ttgatttctg gtggtggatt gtccataact     1200

ggatcacata tcttatgtgg agacttcctc ttcagcggtc acacggttac gctgacactg     1260

acttatttgt tcatcaaaga atattcgcct cgtcacttct ggtggtatca tttaatctgc     1320

tggctgctga gtgctgccgg gatcatctgc attcttgtag cacacgaaca ctacactatc     1380

gatgtgatca ttgcttatta tatcacaaca cgactgtttt ggtggtacca ttcaatggcc     1440

aatgaaaaga acttgaaggt ctcttcacag actaatttct tatctcgagc atggtggttc     1500

cccatctttt atttttttga gaaaaatgta caaggctcaa ttccttgctg cttctcctgg     1560

ccgctgtctt ggcctcctgg ctgcttcaaa tcatcatgca aaaagtattc acgggttcag     1620

aagattggtg aagacaatga gaaatcgacc tgaggagcaa aacaaaggca tcagctctta     1680

caccaaaaga gttaacgctg taaccaaagg tatagttttg ttttttattt taggagaact     1740

gactggtaaa tgaagaaatg gaccaaattt tgtgtaaacg attagaaaga tgaacaaagt     1800

attgcccttt gactggtttt cttcttcatc ctgagaaaga tacattctct tgcagctctt     1860

cattcattgg tgacaagccc ccaccccggg actttactaa tgagcttgtt aaagaggtgc     1920

caaagaacat attcctcctt tctttattct ttctccacca aaaccctcta cttcagaatt     1980

ttttcaggat atttttcagc ccaaggtcag aagaatgtgt taatatttta aataaaatat     2040

ctggacatct acagccactg tgtaaataga actgcctaat gttgagagtg gtttttagca     2100

ttaggtttag caagggggag atccgtgggt tgtgcgtcag ctttgggtga attttgtttc     2160

taccctgtca cggggaaagt tcgggttgag tccaggagtg cacactgctg ctgccaccca     2220

atgcgctaca tatcactttt ttttgttttg ttttgttttg tttttaaaag atcattttat     2280

cttaaaaagg aaagctgatc caagtaaaca cgaaagtatt tgacacaccc cacagatttt     2340

acatgtgtgt aaatgtttca ctttaaaatc tctatgacag atacacagga aacatgagat     2400

ggtttctgct aatgagtggc ccttgagtac acacttagat gctgtctgcc ctgtaaattt     2460

ggatctggtg ccccagggca gtcaactctt ctagcacagg ctgaaaacac gtgtgtgtca     2520

actgaggttc acaccacttg gggaatgagc ctgttttctt tccaggtcag gccctggtgt     2580

gagatcaatt ttagggctcc taattggagc acagaaatgt atttggtcaa atttcattga     2640

aggtgatttc ttcctttttc tgttgtactt tatggaaaaa ccaagatgga acctgaaagt     2700

taatgtatcc ttgcttttag caagagactc agtttcttat aactagtcct aaggacatat     2760

gccgcaattg agtaatttta cttttaccct atgaaaataa catggtgctg cactataata     2820

tactctcgga atcagtgtgt tagttacagc tatacagtga agggggataa ctgtttctaa     2880

atttctttaa ggtgatgcca aaaaatggat taaaaaatct gatcagattt aatgttacca     2940

gatttagtgc attatttaat gctattggat cttttggata attcttggct taatttctta     3000

gctacttgaa ggttaatttg caagactttt aaaaccttag aaaagtttta aggttgcaaa     3060

gttatcaaca ctggggcaga gggtggagag gccaatgcgg gtagaaggag gcagttatgt     3120

ttatattgaa ggtgaaattt ttctttcatt tagaatggaa aacatcccca aatgtatcat     3180

tataaactag tcagccttga ctacacaaaa ttgaccttta agttgcttga gaaaaacaca     3240

atgcaaatcg ttcagaaggg tcaacatcct ttggtgctaa aatcttgtgt atgttttcag     3300

aatggctttt tctgtatgtt atagaataat cactaaagga aaggtagttg aatttaaagt     3360

catgaagcaa gactctttaa ttcagttatt ttaaacaaga attaaaaccc caaacatcct     3420

tggcaggctt tgaagcacac agaattttct agtatttctt attaaataca ccaataataa     3480

acatatactt agtttacctg atgagtttag acataattct atataatgtt cgcttatatt     3540

catttattaa ctagcaacac ttgtgcaaga acaaggtatt ctgcttgaaa acactgattt     3600

ttaagttcct gttgcccgat tgtaaagaaa atcatctgac acagaagcct ggattttgct     3660

ctcctaacac tggtgttttc cttgagcctc taattcaaat aaaacaaact gatacacctt     3720

acagccttat tcatctgtgt ctggataact cacttttcat ctattgaata agaaaaagtg     3780

tttaaactta ataaaataaa aaattgtgca ccaattacta cagatccttg aaacagtaag     3840

ccttggattt tagtcaagta atccagtttt tttttaattt aaaaaaaacc atcacctttt     3900

aaagaacttt aaaaacacct gtgatgccaa tgtggacatt gccgctgcca tgtctttaca     3960

cgcatgtgtc gtatagctct gtcatcgagt tgaggaagtc catggtttgc aaataagggt     4020

gggggaatca aaatttcaag atggaaaaat aaaacaaata gtaaaaccca tttacatgta     4080

ggaaagaaaa gttgagcttc aacccaatgt gccactttga tataaaacaa gtatgatata     4140

tatataaact gaagatataa aacaagtatg atcttgcctt tgaaatcata aatgtttggg     4200

gtacctgttc tttgccagtt aagatacata tcttattatc tttgtttttt tcaagtctat     4260

gctcctgttt gaagcttttc ctgtaattta ggttgtctgt gaaataccta taacatataa     4320

ttcctataga gtatgccaca ttttttttct aactcatttc aaatgaaatt ctctcagatt     4380

ctagtttttg agcttgtcca ctagatctga aaataaagca tcctttcctg agtccacttg     4440

aactaattgt gaatttgtta cttaatttac tggcatcttg ggaaacaagt tttgctgtgg     4500

caggaaggct gttttgagag tgagcgttga gtctactctg gtttgtggat gacattgcat     4560

tagggttatt tcctgtatta ccagtgcccc cttgtggcaa tatactttat gacttggaat     4620

gcaaacacca cttttaaaag cctgttttca agtttttgaa aggcatttgt tttctgttgt     4680

ttgccaataa tctgaaagta tcatgtgaaa ggaattattt taaaagcatt ttaaaccttt     4740

cccaaaggta aaatgtgctc agattatagg cacttgtaat tctaaccttg tatccatttg     4800

atcaaagaaa atttgtagaa catttttacc tctcatgatc acaatcatta gtgtctccct     4860

ttataacgac ctatgttttg tttactttga aacaccaaat ttgttgtctt ggtttttttt     4920

acatgacaga actcatgcag tttctttttt agttgaaagt tcacatcttg ccccttgaat     4980

agtttgaaca tttctttctt aattcttttt tgtttttgtt ttgcactgta aaactgatga     5040

aaactttaag ccaatcttaa tgcactagcc tctgtagtgt aaggaagtgt gagaaggagt     5100

ttcttaatga gtttacacgt ttaaatcaag catattataa gttatatgcc atgtgttgaa     5160

ggcttttcta tttatatata taaagatttt tagtatttgt ttttagtgtc cttgtgttgc     5220

aataatttaa ctcctttgac tcagttgctg aaaatatttc ttctattaag aagtgctctt     5280

gacttcaaca cccaaacact gaaaatcatg tcaatgttac ccaaagataa gtttttatac     5340

agatacacac cttataagtt ctgatttatt ttcttactca ttatgctgtg ttctaaataa     5400

atcatgaatg agaagagtgc tttattgtga aattatttaa aactgtcctt taaaagaaaa     5460

agaggaaacg atgaacaaaa actaatctaa ttgccaagtt agaattcatt atttaattta     5520

cctcctatgc aatgattaat gctgcaaaat gtatggttat gttaccgtat attcacaaaa     5580

gaaatattat tacaaggttt cagaggtagc caattgcatt cttttggaaa tttactgtac     5640

tgtttcaatg tgttaagtgc cttgttgtaa agtaaaattt taagtctaga ttcattattt     5700

tcctgacata tatttttcat tatgatatct actgtatgct attgtgatag ttttatgaaa     5760

tgcttacatt ttaatcaaat atgtaaattt cagaagctct tttttcctac ccaccagtac     5820

cttaatcatt ggtttatcac attggattca aattcaggtt ccttttttga taaagaggaa     5880

atttgttttc catgcttgtg attttgtgtt tgtaaacatt tcaggaggaa tttaggagtg     5940

taactatagt ttatacttct ataatgttgt cttacattta catttttaag tgcctaattg     6000

ttaaaactga tttatgtttc tcttctaaag aggatatgtg tacttggttt ctaatctctt     6060

tggttttgct ttttaaaaaa tgcaagagcc tatactttgt atttacctaa taaaccacag     6120

tgacatcaac agtcttttca aaattaaaaa aaaaaaaaaa aa                        6162


<210>  865
<211>  365
<212>  PRT
<213>  Homo Sapiens

<400>  865

Met Asp Ile Ile Glu Thr Ala Lys Leu Glu Glu His Leu Glu Asn Gln 
1               5                   10                  15      


Pro Ser Asp Pro Thr Asn Thr Tyr Ala Arg Pro Ala Glu Pro Val Glu 
            20                  25                  30          


Glu Glu Asn Lys Asn Gly Asn Gly Lys Pro Lys Ser Leu Ser Ser Gly 
        35                  40                  45              


Leu Arg Lys Gly Thr Lys Lys Tyr Pro Asp Tyr Ile Gln Ile Ala Met 
    50                  55                  60                  


Pro Thr Glu Ser Arg Asn Lys Phe Pro Leu Glu Trp Trp Lys Thr Gly 
65                  70                  75                  80  


Ile Ala Phe Ile Tyr Ala Val Phe Asn Leu Val Leu Thr Thr Val Met 
                85                  90                  95      


Ile Thr Val Val His Glu Arg Val Pro Pro Lys Glu Leu Ser Pro Pro 
            100                 105                 110         


Leu Pro Asp Lys Phe Phe Asp Tyr Ile Asp Arg Val Lys Trp Ala Phe 
        115                 120                 125             


Ser Val Ser Glu Ile Asn Gly Ile Ile Leu Val Gly Leu Trp Ile Thr 
    130                 135                 140                 


Gln Trp Leu Phe Leu Arg Tyr Lys Ser Ile Val Gly Arg Arg Phe Cys 
145                 150                 155                 160 


Phe Ile Ile Gly Thr Leu Tyr Leu Tyr Arg Cys Ile Thr Met Tyr Val 
                165                 170                 175     


Thr Thr Leu Pro Val Pro Gly Met His Phe Gln Cys Ala Pro Lys Leu 
            180                 185                 190         


Asn Gly Asp Ser Gln Ala Lys Val Gln Arg Ile Leu Arg Leu Ile Ser 
        195                 200                 205             


Gly Gly Gly Leu Ser Ile Thr Gly Ser His Ile Leu Cys Gly Asp Phe 
    210                 215                 220                 


Leu Phe Ser Gly His Thr Val Thr Leu Thr Leu Thr Tyr Leu Phe Ile 
225                 230                 235                 240 


Lys Glu Tyr Ser Pro Arg His Phe Trp Trp Tyr His Leu Ile Cys Trp 
                245                 250                 255     


Leu Leu Ser Ala Ala Gly Ile Ile Cys Ile Leu Val Ala His Glu His 
            260                 265                 270         


Tyr Thr Ile Asp Val Ile Ile Ala Tyr Tyr Ile Thr Thr Arg Leu Phe 
        275                 280                 285             


Trp Trp Tyr His Ser Met Ala Asn Glu Lys Asn Leu Lys Val Ser Ser 
    290                 295                 300                 


Gln Thr Asn Phe Leu Ser Arg Ala Trp Trp Phe Pro Ile Phe Tyr Phe 
305                 310                 315                 320 


Phe Glu Lys Asn Val Gln Gly Ser Ile Pro Cys Cys Phe Ser Trp Pro 
                325                 330                 335     


Leu Ser Trp Pro Pro Gly Cys Phe Lys Ser Ser Cys Lys Lys Tyr Ser 
            340                 345                 350         


Arg Val Gln Lys Ile Gly Glu Asp Asn Glu Lys Ser Thr 
        355                 360                 365 


<210>  866
<211>  1515
<212>  DNA
<213>  Homo Sapiens

<400>  866
ccggcccacg ccagctcccg gccgcggcac agcagccccg gcgctccccg cgccgccccg       60

cgcaggcgcc cccgccccgc cgtcgccgcc gccgcagcca ggagccgctg caccatgccc      120

cgcatagatg cggacctcaa gctcgacttc aaggatgtcc tgctccgacc taagcggagc      180

agcctcaaga gccgagccga ggtggatctt gaacgcacct tcacgtttcg aaattcaaag      240

cagacctact cagggattcc catcatcgtg gccaacatgg acactgtggg cacgtttgag      300

atggcagccg tgatgtcaca gcactccatg tttacagcaa ttcataagca ttactccctg      360

gatgactgga agctctttgc cacaaatcac ccagaatgcc tgcagaatgt agccgtgagt      420

tcaggcagtg ggcagaatga tctggaaaag atgaccagca tcctggaagc tgtgccacag      480

gttaagttta tttgcctgga tgtggccaat gggtattcag aacattttgt ggaattcgtg      540

aaacttgtcc gtgccaaatt tcctgaacac accattatgg cagggaacgt ggtgacagga      600

gaaatggtag aagagcttat tctttccgga gcagatatca tcaaagtggg agttggacca      660

ggttctgtgt gcaccacccg caccaagacg ggagtggggt acccccagct gagtgccgtc      720

attgagtgtg ccgactctgc ccatggcctg aagggccaca tcatctctga tggaggctgt      780

acgtgtccag gggatgtcgc caaagccttt ggagctggag cagattttgt catgctggga      840

ggaatgtttt cgggtcatac ggagtgtgct ggagaagtgt ttgagaggaa cggacggaag      900

ctcaagctct tctacgggat gagctctgac accgccatga acaagcacgc aggaggagtt      960

gctgagtaca gagcctctga gggtaagact gtggaagttc cttacaaagg agatgtggaa     1020

aacactatcc tggatattct cgggggactg aggtccacgt gcacctacgt gggggccgcc     1080

aaactcaagg agctcagcag gagggcaaca ttcatccggg tgacccagca gcacaacacc     1140

gtgttcagct aaccctgggg acaaagcagc gtctggctcg agtggaagcg tccaaacctg     1200

cttttcccat ctccccccaa gtctgttccg tcagagcttc tggctgctcc tgaatggtgg     1260

aatgctgtgt cctctcttct gtctcctgct gcctggaggc ttcggggctc tcccgcctgc     1320

cttctcgggg cccagacgca aggcaccgat tgggccaaca tcagagccct gctgcccaga     1380

actcataacc tcattgttca aaccaacact tgcacctttc tctttttctc tttctctctc     1440

cctttctttg tttttctttc ttttttaaaa gaagatggtt tcactttaat ataatgctat     1500

tatcttaaga cttaa                                                      1515


<210>  867
<211>  345
<212>  PRT
<213>  Homo Sapiens

<400>  867

Met Pro Arg Ile Asp Ala Asp Leu Lys Leu Asp Phe Lys Asp Val Leu 
1               5                   10                  15      


Leu Arg Pro Lys Arg Ser Ser Leu Lys Ser Arg Ala Glu Val Asp Leu 
            20                  25                  30          


Glu Arg Thr Phe Thr Phe Arg Asn Ser Lys Gln Thr Tyr Ser Gly Ile 
        35                  40                  45              


Pro Ile Ile Val Ala Asn Met Asp Thr Val Gly Thr Phe Glu Met Ala 
    50                  55                  60                  


Ala Val Met Ser Gln His Ser Met Phe Thr Ala Ile His Lys His Tyr 
65                  70                  75                  80  


Ser Leu Asp Asp Trp Lys Leu Phe Ala Thr Asn His Pro Glu Cys Leu 
                85                  90                  95      


Gln Asn Val Ala Val Ser Ser Gly Ser Gly Gln Asn Asp Leu Glu Lys 
            100                 105                 110         


Met Thr Ser Ile Leu Glu Ala Val Pro Gln Val Lys Phe Ile Cys Leu 
        115                 120                 125             


Asp Val Ala Asn Gly Tyr Ser Glu His Phe Val Glu Phe Val Lys Leu 
    130                 135                 140                 


Val Arg Ala Lys Phe Pro Glu His Thr Ile Met Ala Gly Asn Val Val 
145                 150                 155                 160 


Thr Gly Glu Met Val Glu Glu Leu Ile Leu Ser Gly Ala Asp Ile Ile 
                165                 170                 175     


Lys Val Gly Val Gly Pro Gly Ser Val Cys Thr Thr Arg Thr Lys Thr 
            180                 185                 190         


Gly Val Gly Tyr Pro Gln Leu Ser Ala Val Ile Glu Cys Ala Asp Ser 
        195                 200                 205             


Ala His Gly Leu Lys Gly His Ile Ile Ser Asp Gly Gly Cys Thr Cys 
    210                 215                 220                 


Pro Gly Asp Val Ala Lys Ala Phe Gly Ala Gly Ala Asp Phe Val Met 
225                 230                 235                 240 


Leu Gly Gly Met Phe Ser Gly His Thr Glu Cys Ala Gly Glu Val Phe 
                245                 250                 255     


Glu Arg Asn Gly Arg Lys Leu Lys Leu Phe Tyr Gly Met Ser Ser Asp 
            260                 265                 270         


Thr Ala Met Asn Lys His Ala Gly Gly Val Ala Glu Tyr Arg Ala Ser 
        275                 280                 285             


Glu Gly Lys Thr Val Glu Val Pro Tyr Lys Gly Asp Val Glu Asn Thr 
    290                 295                 300                 


Ile Leu Asp Ile Leu Gly Gly Leu Arg Ser Thr Cys Thr Tyr Val Gly 
305                 310                 315                 320 


Ala Ala Lys Leu Lys Glu Leu Ser Arg Arg Ala Thr Phe Ile Arg Val 
                325                 330                 335     


Thr Gln Gln His Asn Thr Val Phe Ser 
            340                 345 


<210>  868
<211>  7202
<212>  DNA
<213>  Homo Sapiens

<400>  868
gatgtgtgtg gggttcggag ccgcgccggc acagccgaag ggagcgggcg agcggcgacg       60

gcggcggcgg cgggcacaga ttaattaaaa gaagaatgaa ctataatcct tgaagataac      120

tgggcaattt tttaagtcgg aggctgttct tactggtgtg aggatttaca cacgtcttca      180

gtttttcagc acagaccagc agaccatcat ttttagagga aatactccct ctgccctcct      240

ttttggtttc cttggtggta aagattaaat ttggttgcat cattttgact tgtgtttgag      300

tctagatttt atggcacaag gaatggcata aacttttcat gtgttttggt taaaacaaac      360

cagaccattg cattgaccct ggacatcttt aattgagaaa ttggtaactt tattttaata      420

tgtatatctg aagaattcaa gaaaacaaag gcatcctcag aggtgtgcct cttttcttta      480

ttattagagg caaaacgaac aattttatag gatttgtagt gaaattatac cagattataa      540

ggagaaccaa aactaagtcg caaaatttat taatttaagg ggctctcgct ttgaaagttt      600

gagagtaagt tacgataggc atttgtatcc attcattact ttcctctttt caaataagca      660

actaaataga aatgctaatc tcagacttaa ttatttaaca gaagagtgta ccatggaaaa      720

cctccagaca aatttctcct tggttcaggg ctcaactaaa aaactgaatg ggatgggaga      780

tgatggcagc cccccagcga aaaaaatgat aacggacatt catgcaaatg gaaaaacgat      840

aaacaaggtg ccaacagtta agaaggaaca cttggatgac tatggagaag caccagtgga      900

aactgatgga gagcatgtta agcgaacctg tacttctgtt cctgaaactt tgcatttaaa      960

tcccagtttg aaacacacat tggcacaatt ccatttaagt agtcagagct cgctgggtgg     1020

accagcagca ttttctgctc ggcattccca agaaagcatg tcgcctactg tatttctgcc     1080

tcttccatca cctcaggttc ttcctggccc attgctcatc ccttcagata gctccacaga     1140

actcactcag actgtgttgg aaggggaatc tatttcttgt tttcaagttg gaggagaaaa     1200

gagactctgt ttgccccaag tcttaaattc tgttctccga gaatttacac tccagcaaat     1260

aaatacagtg tgtgatgaac tgtacatata ttgttcaagg tgtacttcag accagcttca     1320

tatcttaaag gtactgggca tacttccatt caatgcccca tcctgtgggc tgattacatt     1380

aactgatgca caaagattat gtaatgcttt attgcggcca cgaacttttc ctcaaaatgg     1440

tagcgtactt cctgctaaaa gctcattggc ccagttaaag gaaactggca gtgcctttga     1500

agtggagcat gaatgcctag gcaaatgtca gggtttattt gcaccccagt tttatgttca     1560

gcctgatgct ccgtgtattc aatgtctgga gtgttgtgga atgtttgcac cccagacgtt     1620

tgtgatgcat tctcacagat cacctgacaa aagaacttgc cactggggct ttgaatcagc     1680

taaatggcat tgctatcttc atgtgaacca aaaatactta ggaacacctg aagaaaagaa     1740

actgaagata attttagaag aaatgaagga gaagtttagc atgagaagtg gaaagagaaa     1800

tcaatccaag acagatgcac catcaggaat ggaattacag tcatggtatc ctgttataaa     1860

gcaggaaggt gaccatgttt ctcagacaca ttcattttta caccccagct actacttata     1920

catgtgtgat aaagtggttg ccccaaatgt gtcacttact tctgctgtat cccagtctaa     1980

agagctcaca aagacagagg caagtaagtc catatcaaga cagtcagaga aggctcacag     2040

tagtggtaaa cttcaaaaaa cagtgtctta tccagatgtc tcacttgagg aacaggagaa     2100

aatggattta aaaacaagta gagaattatg tagccgttta gatgcatcaa tctcaaataa     2160

ttctacaagt aaaaggaaat ctgagtctgc cacttgcaac ttagtcagag acataaacaa     2220

agtgggaatt ggccttgttg ctgccgcttc atctccgctt cttgtgaaag atgtcatttg     2280

tgaggatgat aagggaaaaa tcatggaaga agtaatgaga acttatttaa aacaacagga     2340

aaaactaaac ttgattttgc aaaagaagca acaacttcag atggaagtaa aaatgttgag     2400

tagttcaaaa tctatgaagg aactcactga agaacagcag aatttacaga aagagcttga     2460

atctttgcag aatgaacatg ctcaaagaat ggaagaattt tatgttgaac agaaagactt     2520

agagaaaaaa ttggagcaga taatgaagca aaaatgtacc tgtgactcaa atttagaaaa     2580

agacaaagag gctgaatatg caggacagtt ggcagaactg aggcagagat tggaccatgc     2640

tgaggccgat aggcaagaac tccaagatga actcagacag gaacgggaag caagacagaa     2700

gttagagatg atgataaaag agctaaagct gcaaattctg aaatcatcaa agactgctaa     2760

agaatagaaa ctgttaaaga gattcatctg tgtattactg acaaggtttt ttttgtttgt     2820

tgcttgcttt ggtaattgaa ttctgaagaa tttatctgca tgacgataac taggcattct     2880

atccatttgt agatcagaga aagtgaagag attatatatt agtacttaaa tttttacatt     2940

ttccaaatga atgaaaatgt atgtttcttt gtactttttt aaaaaaatca gcttagtaac     3000

aatactatat ggtttcaact agtaggtaat ctgcttatat ttctaatgca aacttaacaa     3060

ttgtgtactt tttaaaagct gcaatatgtg ttggaaaata gctgtggtca attttgttat     3120

ccatatttca gactcaattt tagatacaat ggtggcttta tattttaagt atatagagct     3180

actcaaggag ttgaatctcc ccttttctca ttaacacaat ttttctaagt tgatatggtg     3240

tactcattaa catacaccaa atttactttt actttgttca gattgtggaa tgaatttcca     3300

ccagttctct tctttttaat gtgtacccta ggaggaattt tactgaggtt atagcatacc     3360

ccatgagcac agtggggaag aagaatgtgt tgttatgtgc tgctgctaaa cagaagcagc     3420

agttgtaatt tgtttttcag tttaaatgtg gttatagtta gatttttttt taagcagcaa     3480

cttttcaaaa ataaaatgtg ataatttctg aacttttgtt tgtgttgtta atagtggtgt     3540

gaaaatatta acgttcttga gaaaaactga taccactgtt gtgtatcagt ttctatacaa     3600

tccataatcc tcctgtacag tttttacatg tagttatgag tcttactaaa atttatataa     3660

tggacttgtt ttcctttaag ttgtaaaatg ttaaacacct tgaaggttat tttggacttc     3720

tgtatgttta aatgttgtct taccaaaatt tgcacgaatg gaccattttc atttactact     3780

taatatcaaa atcaggaatt tacagtcaac tgatagtaca tgataggtgc atataggaca     3840

gtttagttac ctgctactaa aagattttta gataagtttt agaagataaa ggaattccat     3900

agtttcagga gggacaacat cttctgcact ttttttttgc acagaaaagt ctgtcattct     3960

ctaatggcaa atttcatatt tgttaattct tggctcaaaa tatattaggt aaaattctta     4020

gatctgtttt taaagggagt ttcctgaaac tatcattaat tgacattatt accccatgga     4080

ttttatggga taataaatgt ttttcatgtt ctcttataag atactatgta tgaaattact     4140

tcagagagct atatttattt taaaataaat tagctagggt taaggttata ttctatttcc     4200

agcatagaag gtagataatc taatggtgta gaaagaatca ctaggttgtc atttaaccag     4260

ttattttcat attttgctta atagtacata tccaaaaaga attttgtact tccccaaatg     4320

taatttattt actaaattga gtataaccta aatgtgtgtt ttctattttc catttaaatt     4380

ttgctatatt aagactaatt taattcgttg agtcttggaa tcttctcaag gaggaacaaa     4440

tattaaaatg acatgtagaa acaaattttt tttttttttt tttttttttt ttttttgaga     4500

cagagtctcg ctgtctccca ggctggagtt cagtggtgca atctcggctc actgcaagct     4560

ctgcctcctg ggttcaagcc attctcctgc ctcagcctcc cgagtagctg ggactacagg     4620

cacccaccac cactcccggc taatttttag aaacaaatat ttaaaatgac atattctccc     4680

aatacaatct atttagatct ggagaaggaa aaatcagata tttatgatat agttttattt     4740

taattttgaa ttatttgtgt cacagctcag ctttttggaa gacaaactca aacacctata     4800

atttcattta tatttctaat tcacttggaa cctttctgct ttatgttacc tagaaaatga     4860

taatttgttt aacccaaaac ttctaaaata aattgcttaa tccttgaaat atgttattgg     4920

aaaattttaa gcagtgctta aacaccatta aattattatg aacttgtaat tcagaattga     4980

gtaaagaaat attttttcta gtccttcata tattgaaaac ttgccacatg acattgtatc     5040

gtcttcattt tccagaagat gcgttggtgt gccataggtt tctaacttcc ttgaaaatag     5100

ttttttaagt caattgtaaa tatacgtatt attgttaaaa gtaactttaa actgcaacac     5160

atagcttcaa aacaatatag agattttgta ataccttata agtggagttg gctaaaatac     5220

cttatccata taaaacttat tctattcttt gcatgcttat tttgtgtgtt ggttgctagc     5280

ttaaagtttg atttgttgtt actctttgtg tgccaaattc actaggcaag cggatttttc     5340

ctcagacttc aaaaaataat tcttttaaga aaaaatgtaa aaatgtttat tctaaaaagc     5400

tgcattaaag ggacaaccta taaaaagttt tgctagctca tctttagaag gaagaaagaa     5460

tattagcttg ggtgatgttt aatttgggtg gcgatagttt ctgtaggcta aactttatga     5520

gaaaagtgta cctactctat aaaggtaata aatgtaaaac ctcttgctgt tattgaggaa     5580

gctcttcaac taccctaaat ttcacaaatg taacttataa cactatgaaa agatttgacc     5640

aacaatttac gtttgctgtg tgctttagtt tttgtttaag catattcttt tgcttgaatt     5700

tctgtgttca tgagagttag ggtgttttat gcttcttgaa ctaattttat aacatattta     5760

atatattacc agttaagata taaaatcatt tgtacatagc gaattgtaaa gcagctatta     5820

aagtaggtga aataaagtat atatttgccg gttatccata tcttttagaa gtcctgacag     5880

aacaaccagt ttatttgcac ataggtagct tctgtttgaa ggaaggtaaa gttataagga     5940

aactcaaata ctataagatg tgtcaaggta tttctccaga attaattgca aagctagtgc     6000

tgaaggattt taatcagctt ctaaaatttt cttctcaata aggcatatgt tttgattact     6060

tagggaagat tcctcatttt tatttgccct ttatgcattt aatccacatg ataggacatt     6120

aaaaattaat ataaagaaaa atcgtgctca tactgtacat ctgtttctgt gcttggaact     6180

acttgttaat agtttttatc gaagctgtca gcaataaggg acataaaact gctgtattat     6240

acattgtgga attgaataaa cagcctaatt ttttttttct agtatagggt acttaagcat     6300

ttccactttt ggaagaaaag tgtattagta ttttatattg catttcattt aaaaggacag     6360

tttttttttt ttttttgtaa atccattcat tgaaatggtt tctaaactgt ataatgtaat     6420

ttggagccta tttagtaata gaattaaatg tcctatgtag tgctacaatt tttgaattag     6480

aaagtgatca aatgtaagaa aaaaatttaa aaattcagcc cagaaaacaa aatagtgtat     6540

taaattagtt taatgtaaaa ggaatttata agattttttt cctcaatata gatacctcac     6600

ttgaaaagaa agcacagcat acttaaagta gttctagtaa acatgtccta gaaaacagtt     6660

gctaaatgta ggacatcttt tgaggaatta gtttatgaga aataaaattt tacttgtttt     6720

tactatcctg ttagaagtat ttgtttatcc tgataatttt aagccaacat agtagtctta     6780

aattactttt gaatttctaa tctgtgaagg cagtaaatga aatatctgtt ctgcaactgt     6840

tgaaacaaat aattggctac attgaccata attaaagtta aaattttgcc aatgatgtac     6900

agttttatgg ttaaagttgc tgtggttggt tgcattacat gacacagaaa actgtcctct     6960

acctcacgtg aaataaatat tttatatggt tttactaaaa ataagactca tgtatctggt     7020

cacctagttt acaaattttg aattatattt attgaaacat gacatactgt gctctgagct     7080

tatacctcaa ttgtattttg tgctgttttc cattttcatg ccttgtaaat aacttgtata     7140

gattgtggat caaatactaa ataaaaactt ttaatgccaa ttaaatttga ttcaagttaa     7200

aa                                                                    7202


<210>  869
<211>  684
<212>  PRT
<213>  Homo Sapiens

<400>  869

Met Glu Asn Leu Gln Thr Asn Phe Ser Leu Val Gln Gly Ser Thr Lys 
1               5                   10                  15      


Lys Leu Asn Gly Met Gly Asp Asp Gly Ser Pro Pro Ala Lys Lys Met 
            20                  25                  30          


Ile Thr Asp Ile His Ala Asn Gly Lys Thr Ile Asn Lys Val Pro Thr 
        35                  40                  45              


Val Lys Lys Glu His Leu Asp Asp Tyr Gly Glu Ala Pro Val Glu Thr 
    50                  55                  60                  


Asp Gly Glu His Val Lys Arg Thr Cys Thr Ser Val Pro Glu Thr Leu 
65                  70                  75                  80  


His Leu Asn Pro Ser Leu Lys His Thr Leu Ala Gln Phe His Leu Ser 
                85                  90                  95      


Ser Gln Ser Ser Leu Gly Gly Pro Ala Ala Phe Ser Ala Arg His Ser 
            100                 105                 110         


Gln Glu Ser Met Ser Pro Thr Val Phe Leu Pro Leu Pro Ser Pro Gln 
        115                 120                 125             


Val Leu Pro Gly Pro Leu Leu Ile Pro Ser Asp Ser Ser Thr Glu Leu 
    130                 135                 140                 


Thr Gln Thr Val Leu Glu Gly Glu Ser Ile Ser Cys Phe Gln Val Gly 
145                 150                 155                 160 


Gly Glu Lys Arg Leu Cys Leu Pro Gln Val Leu Asn Ser Val Leu Arg 
                165                 170                 175     


Glu Phe Thr Leu Gln Gln Ile Asn Thr Val Cys Asp Glu Leu Tyr Ile 
            180                 185                 190         


Tyr Cys Ser Arg Cys Thr Ser Asp Gln Leu His Ile Leu Lys Val Leu 
        195                 200                 205             


Gly Ile Leu Pro Phe Asn Ala Pro Ser Cys Gly Leu Ile Thr Leu Thr 
    210                 215                 220                 


Asp Ala Gln Arg Leu Cys Asn Ala Leu Leu Arg Pro Arg Thr Phe Pro 
225                 230                 235                 240 


Gln Asn Gly Ser Val Leu Pro Ala Lys Ser Ser Leu Ala Gln Leu Lys 
                245                 250                 255     


Glu Thr Gly Ser Ala Phe Glu Val Glu His Glu Cys Leu Gly Lys Cys 
            260                 265                 270         


Gln Gly Leu Phe Ala Pro Gln Phe Tyr Val Gln Pro Asp Ala Pro Cys 
        275                 280                 285             


Ile Gln Cys Leu Glu Cys Cys Gly Met Phe Ala Pro Gln Thr Phe Val 
    290                 295                 300                 


Met His Ser His Arg Ser Pro Asp Lys Arg Thr Cys His Trp Gly Phe 
305                 310                 315                 320 


Glu Ser Ala Lys Trp His Cys Tyr Leu His Val Asn Gln Lys Tyr Leu 
                325                 330                 335     


Gly Thr Pro Glu Glu Lys Lys Leu Lys Ile Ile Leu Glu Glu Met Lys 
            340                 345                 350         


Glu Lys Phe Ser Met Arg Ser Gly Lys Arg Asn Gln Ser Lys Thr Asp 
        355                 360                 365             


Ala Pro Ser Gly Met Glu Leu Gln Ser Trp Tyr Pro Val Ile Lys Gln 
    370                 375                 380                 


Glu Gly Asp His Val Ser Gln Thr His Ser Phe Leu His Pro Ser Tyr 
385                 390                 395                 400 


Tyr Leu Tyr Met Cys Asp Lys Val Val Ala Pro Asn Val Ser Leu Thr 
                405                 410                 415     


Ser Ala Val Ser Gln Ser Lys Glu Leu Thr Lys Thr Glu Ala Ser Lys 
            420                 425                 430         


Ser Ile Ser Arg Gln Ser Glu Lys Ala His Ser Ser Gly Lys Leu Gln 
        435                 440                 445             


Lys Thr Val Ser Tyr Pro Asp Val Ser Leu Glu Glu Gln Glu Lys Met 
    450                 455                 460                 


Asp Leu Lys Thr Ser Arg Glu Leu Cys Ser Arg Leu Asp Ala Ser Ile 
465                 470                 475                 480 


Ser Asn Asn Ser Thr Ser Lys Arg Lys Ser Glu Ser Ala Thr Cys Asn 
                485                 490                 495     


Leu Val Arg Asp Ile Asn Lys Val Gly Ile Gly Leu Val Ala Ala Ala 
            500                 505                 510         


Ser Ser Pro Leu Leu Val Lys Asp Val Ile Cys Glu Asp Asp Lys Gly 
        515                 520                 525             


Lys Ile Met Glu Glu Val Met Arg Thr Tyr Leu Lys Gln Gln Glu Lys 
    530                 535                 540                 


Leu Asn Leu Ile Leu Gln Lys Lys Gln Gln Leu Gln Met Glu Val Lys 
545                 550                 555                 560 


Met Leu Ser Ser Ser Lys Ser Met Lys Glu Leu Thr Glu Glu Gln Gln 
                565                 570                 575     


Asn Leu Gln Lys Glu Leu Glu Ser Leu Gln Asn Glu His Ala Gln Arg 
            580                 585                 590         


Met Glu Glu Phe Tyr Val Glu Gln Lys Asp Leu Glu Lys Lys Leu Glu 
        595                 600                 605             


Gln Ile Met Lys Gln Lys Cys Thr Cys Asp Ser Asn Leu Glu Lys Asp 
    610                 615                 620                 


Lys Glu Ala Glu Tyr Ala Gly Gln Leu Ala Glu Leu Arg Gln Arg Leu 
625                 630                 635                 640 


Asp His Ala Glu Ala Asp Arg Gln Glu Leu Gln Asp Glu Leu Arg Gln 
                645                 650                 655     


Glu Arg Glu Ala Arg Gln Lys Leu Glu Met Met Ile Lys Glu Leu Lys 
            660                 665                 670         


Leu Gln Ile Leu Lys Ser Ser Lys Thr Ala Lys Glu 
        675                 680                 


<210>  870
<211>  8051
<212>  DNA
<213>  Homo Sapiens

<400>  870
atcccggggc agccgagggc ccctgactcg gctcctcgcg gcgacatgga tcggatggcc       60

agctccatga agcaggtgcc caacccactg cccaaggtgc tgagccggcg cggggtcggc      120

gctgggctgg aggcggcgga gcgcgagagc ttcgagcgga ctcagactgt cagcatcaat      180

aaggccatta atacgcagga agtggctgta aaggaaaaac acgccagaac gtgcatactg      240

ggcacccacc atgagaaagg ggcacagacc ttctggtctg ttgtcaaccg cctgcctctg      300

tctagcaacg cagtgctctg ctggaagttc tgccatgtgt tccacaaact cctccgagat      360

ggacacccga acgtcctgaa ggactctctg agatacagaa atgaattgag tgacatgagc      420

aggatgtggg gccacctgag cgaggggtat ggccagctgt gcagcatcta cctgaaactg      480

ctaagaacca agatggagta ccacaccaaa aatcccaggt tcccaggcaa cctgcagatg      540

agtgaccgcc agctggacga ggctggagaa agtgacgtga acaacttttt ccagttaaca      600

gtggagatgt ttgactacct ggagtgtgaa ctcaacctct tccaaacagt attcaactcc      660

ctggacatgt cccgctctgt gtccgtgacg gcagcagggc agtgccgcct cgccccgctg      720

atccaggtca tcttggactg cagccacctt tatgactaca ctgtcaagct tctcttcaaa      780

ctccactcct gcctcccagc tgacaccctg caaggccacc gggaccgctt catggagcag      840

tttacaaagt tgaaagatct gttctaccgc tccagcaacc tgcagtactt caagcggctc      900

attcagatcc cccagctgcc tgagaaccca cccaacttcc tgcgagcctc agccctgtca      960

gaacatatca gccctgtggt ggtgatccct gcagaggcct catcccccga cagcgagcca     1020

gtcctagaga aggatgacct catggacatg gatgcctctc agcagaattt atttgacaac     1080

aagtttgatg acatctttgg cagttcattc agcagtgatc ccttcaattt caacagtcaa     1140

aatggtgtga acaaggatga gaaggaccac ttaattgagc gactatacag agagatcagt     1200

ggattgaagg cacagctaga aaacatgaag actgagagcc agcgggttgt gctgcagctg     1260

aagggccacg tcagcgagct ggaagcagat ctggccgagc agcagcacct gcggcagcag     1320

gcggccgacg actgtgaatt cctgcgggca gaactggacg agctcaggag gcagcgggag     1380

gacaccgaga aggctcagcg gagcctgtct gagatagaaa ggaaagctca agccaatgaa     1440

cagcgatata gcaagctaaa ggagaagtac agcgagctgg ttcagaacca cgctgacctg     1500

ctgcggaaga atgcagaggt gaccaaacag gtgtccatgg ccagacaagc ccaggtagat     1560

ttggaacgag agaaaaaaga gctggaggat tcgttggagc gcatcagtga ccagggccag     1620

cggaagactc aagaacagct ggaagttcta gagagcttga agcaggaact tgccacaagc     1680

caacgggagc ttcaggttct gcaaggcagc ctggaaactt ctgcccagtc agaagcaaac     1740

tgggcagccg agttcgccga gctagagaag gagcgggaca gcctggtgag tggcgcagct     1800

catagggagg aggaattatc tgctcttcgg aaagaactgc aggacactca gctcaaactg     1860

gccagcacag aggaatctat gtgccagctt gccaaagacc aacgaaaaat gcttctggtg     1920

gggtccagga aggctgcgga gcaggtgata caagacgccc tgaaccagct tgaagaacct     1980

cctctcatca gctgcgctgg gtctgcagat cacctcctct ccacggtcac atccatttcc     2040

agctgcatcg agcaactgga gaaaagctgg agccagtatc tggcctgccc agaagacatc     2100

agtggacttc tccattccat aaccctgctg gcccacttga ccagcgacgc cattgctcat     2160

ggtgccacca cctgcctcag agccccacct gagcctgccg actcactgac cgaggcctgt     2220

aagcagtatg gcagggaaac cctcgcctac ctggcctccc tggaggaaga gggaagcctt     2280

gagaatgccg acagcacagc catgaggaac tgcctgagca agatcaaggc catcggcgag     2340

gagctcctgc ccaggggact ggacatcaag caggaggagc tgggggacct ggtggacaag     2400

gagatggcgg ccacttcagc tgctattgaa actgccacgg ccagaataga ggagatgctc     2460

agcaaatccc gagcaggaga cacaggagtc aaattggagg tgaatgaaag gatccttggt     2520

tgctgtacca gcctcatgca agctattcag gtgctcatcg tggcctctaa ggacctccag     2580

agagagattg tggagagcgg caggggtaca gcatccccta aagagtttta tgccaagaac     2640

tctcgatgga cagaaggact tatctcagcc tccaaggctg tgggctgggg agccactgtc     2700

atggtggatg cagctgatct ggtggtacaa ggcagaggga aatttgagga gctaatggtg     2760

tgttctcatg aaattgctgc tagcacagcc cagcttgtgg ctgcatccaa ggtgaaagct     2820

gataaggaca gccccaacct agcccagctg cagcaggcct ctcggggagt gaaccaggcc     2880

actgccggcg ttgtggcctc aaccatttcc ggcaaatcac agatcgaaga gacagacaac     2940

atggacttct caagcatgac gctgacacag atcaaacgcc aagagatgga ttctcaggtt     3000

agggtgctag agctagaaaa tgaattgcag aaggagcgtc aaaaactggg agagcttcgg     3060

aaaaagcact acgagcttgc tggtgttgct gagggctggg aagaaggaac agaggcatct     3120

ccacctacac tgcaagaagt ggtaaccgaa aaagaataga gccaaaccaa caccccatat     3180

gtcagtgtaa atccttgtta cctatctcgt gtgtgttatt tccccagcca caggccaaat     3240

ccttggagtc ccaggggcag ccacaccact gccattaccc agtgccgagg acatgcatga     3300

cacttccaaa gactccctcc atagcgacac cctttctgtt tggacccatg gtcatctctg     3360

ttcttttccc gcctccctag ttagcatcca ggctggccag tgctgcccat gagcaagcct     3420

aggtacgaag aggggtggtg gggggcaggg ccactcaaca gagaggacca acatccagtc     3480

ctgctgacta tttgaccccc acaacaatgg gtatccttaa tagaggagct gcttgttgtt     3540

tgttgacagc ttggaaaggg aagatcttat gccttttctt ttctgttttc ttctcagtct     3600

tttcagtttc atcatttgca caaacttgtg agcatcagag ggctgatgga ttccaaacca     3660

ggacactacc ctgagatctg cacagtcaga aggacggcag gagtgtcctg gctgtgaatg     3720

ccaaagccat tctccccctc tttgggcagt gccatggatt tccactgctt cttatggtgg     3780

ttggttgggt tttttggttt tgtttttttt tttaagtttc actcacatag ccaactctcc     3840

caaagggcac acccctgggg ctgagtctcc agggcccccc aactgtggta gctccagcga     3900

tggtgctgcc caggcctctc ggtgctccat ctccgcctcc acactgacca agtgctggcc     3960

cacccagtcc atgctccagg gtcaggcgga gctgctgagt gacagctttc ctcaaaaagc     4020

agaaggagag tgagtgcctt tccctcctaa agctgaatcc cggcggaaag cctctgtccg     4080

cctttacaag ggagaagaca acagaaagag ggacaagagg gttcacacag cccagttccc     4140

gtgacgaggc tcaaaaactt gatcacatgc ttgaatggag ctggtgagat caacaacact     4200

acttccctgc cggaatgaac tgtccgtgaa tggtctctgt caagcgggcc gtctcccttg     4260

gcccagagac ggagtgtggg agtgattccc aactcctttc tgcagacgtc tgccttggca     4320

tcctcttgaa taggaagatc gttccacctt ctacgcaatt gacaaacccg gaagatcaga     4380

tgcaattgct cccatcaggg aagaacccta tacttggttt gctaccctta gtatttatta     4440

ctaacctccc ttaagcagca acagcctaca aagagatgct tggagcaatc agaacttcag     4500

gtgtgactct agcaaggctc atctttctgc ccggctacat cagccttcaa gaatcagaag     4560

aaaggccaag gtgctggact gttactgact tggatcccaa agcaaggaga tcatttggag     4620

ctcttgggtc agagaaaatg agaaaggaca gagccagcgg ctccaactcc tttcagccac     4680

atgccccagg ctctcgctgc cctgtggaca ggatgaggac agagggcaca tgaacagctt     4740

gccagggatg ggcagcccaa cagcactttt cctcttctag atggacccca gcatttaagt     4800

gaccttctga tcttggaaaa acagcgtctt ccttctttat ctatagcaac tcattggtgg     4860

tagccatcaa gcacttccca ggatctgctc caacagaata ttgctaggtt ttgctacatg     4920

acgggttgtg agacttctgt ttgatcactg tgaaccaacc cccatctccc tagcccaccc     4980

ccctccccaa ctccctctct gtgcattttc taagtgggac attcaaaaaa ctctctccca     5040

ggacctcgga tgaccatact cagacgtgtg acctccatac tgggctaagg aagtatcagc     5100

actagaaatt gggcagtctt aatgttgaat gctgctttct gcttagtatt tttttgattc     5160

aaggctcaga aggaatggtg cgtggcttcc ctgtcccagt tgtggcaact aaaccaatcg     5220

gtgtgttctt gatgcgggtc aacatttcca aaagtggcta gtcctcactt ctagatctca     5280

gccattctaa ctcatatgtt cccaattacc aaggggtggc cgggcacagt ggctcacgcc     5340

tgtaatccca gcactttgag aggctgaggt ggtaggatca cctgaggtca ggagttcaag     5400

accagcctgt ccaacatggt gaaaccccca tctctactaa aaataccaaa aattagccga     5460

gcgtagtgac gggtgcccgt aatcccagct actcaggagg ctgagacagg agaatcacct     5520

gaaccccaga ggcagaggtt gcagtgagct gagatcacgc cattgtactc cagcctgggc     5580

aacaagagca aaactccgtc tcaaaaaaaa aaaaaaatta caaatggggc aaacagtcta     5640

gtgtaatgga tcaaattaag attctctgcc cagccgggca cagtggcgca tgcctgtaat     5700

cccagaactt tgggaggcca agacgggatg attgcttgag ctcaggagtt tgagaccagg     5760

ctgggcatca tagcaagacc tcatctctac taaaattcaa aaacaaaatt agccgggcat     5820

gatggtgcat gcctgtagtc tcagctagtt ggggagctaa ggtgggagaa ttgcttgagc     5880

ttgggaagtc gaggctgcag tcagccctga ttgtgccagt gcactccggc ctgggtgaca     5940

gagtgagacc ctgtctcaaa aaaaaaaaga ttctgtgtca gagcccagcc caggagtttg     6000

aggctgcaat gagccatgat ttcccactgc actccagcct gagtgacaga gcgagactcc     6060

atctctttaa aaacaaacaa aaaattatct gaatgatcct gtctctaaaa agaagccaca     6120

gaaatgttta aaaacttcat cgacttagcc tgagtcataa cggttaagaa agcacttaaa     6180

cagaagcaga ggctaattca gtgtcacatg aggaagtagc tgtcagatgt cacataatta     6240

ctttcgtaat agctcagatt agaatggcta ccccattctc tagacaaaat caaattgtcc     6300

tattgtgact cttctaaaaa tgaagatgaa gagctattta atgacacacc ttggattaaa     6360

acgggaatca catcttaaag ctaaaaatga acctgcaagc cttctaaatg agtcactgag     6420

catcactagt gacaagtctc gggtgagcgt aaatgggtca tgacaagatg ggacagcaac     6480

aaaatcatgg cttaggatcg acaagaagtt aaaaaacagc tgcatctgtt acttaagttt     6540

gtaagacagt gccctgagac ctctagagaa aagatgtttg tttacataag agaaagaggc     6600

cagacatggt gtctcacacg tttaatccca gcactttggg aggcaggggc gggtggatca     6660

cctgaggtca ggagttcaag actagcctgg ccaacatggt gaaaccccgt ctctactaaa     6720

aatacaaaaa ttagccgggc atggtggcag gcgcctataa tcccagctac tggggaggct     6780

gaggcaggag aatcacttga acccggggga cagaggttgt agtgagccaa gatcgcacca     6840

ctgcactcca gcctgggtca cagagtgaga ctccatctca aaaaaaaaaa agagagagag     6900

agagaaagaa atagaagaga agagccatct tggcagggtt attttatatc tgagcaagga     6960

gtttaaatga gactagttta gattgtctgc tgatgcagcc gtccatagca gtacccctaa     7020

aatcccacca gaatacgggt ccctctaacc cagtggctgg aagaaccact gtctagagca     7080

acttttcttg gaactgtccc agctaccaag tcagacacca aggtttatgc caccaggtaa     7140

cacgggaatc acaggtacat gtcgctccgg tcagattagt tggctttggc ccctcgaccc     7200

tgtgcaggag ctagttctca gcttgcagct ggaagttccc tcttagctcc ttagtctaga     7260

ggggtctcct ggctccattt gaccctggtc tttaataacc ggtcagcatc ttgctacctt     7320

ctaccacctt tccaaatctc tggaaatcct gccagggaaa gcctccagtt ccaacattgg     7380

ctttccaagc aaactggctt tgccctctct ctgccatcct tgtcctccag agactgcacc     7440

acctgtagca tagaaaacca ccaccacgga cctgccagcc attggcgcag caaaccagcc     7500

agctgtttgc tgccaaattc cttcctctcc caggtccaga ccaaatacaa gatcagcacc     7560

acaccgtggt gttgtcagga gccaaagcaa caggaaacaa ttcaatgctg ttgggttcga     7620

ttctgagagt agatttttcc agacatgtct ttcaggtgac cctcaactac ctcaggtttg     7680

aaggccctaa atgaaactga ttaccactca tagggacaaa ccgagggggt tcggttacat     7740

cttggtgata atgcagttgt ctcaaactta taacagactc tttcacattt cagtttgcag     7800

ggatagggtt gggtttgttt ttcttctgtt tttaaccttt cccctgggtt tccattaggg     7860

tagttccttg aaatgaattt catttttcac tgagtgccta ccttcccagg gcaggtggcc     7920

actggcttct gtttccctcc aacaatactt ttattatggt attaagacct ttctttgtat     7980

aatacattgc atctgtgttt tcaatttttc aaataaatat ttccgcctgg caaaaaaaaa     8040

aaaaaaaaaa a                                                          8051


<210>  871
<211>  1037
<212>  PRT
<213>  Homo Sapiens

<400>  871

Met Asp Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro 
1               5                   10                  15      


Lys Val Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu 
            20                  25                  30          


Arg Glu Ser Phe Glu Arg Thr Gln Thr Val Ser Ile Asn Lys Ala Ile 
        35                  40                  45              


Asn Thr Gln Glu Val Ala Val Lys Glu Lys His Ala Arg Thr Cys Ile 
    50                  55                  60                  


Leu Gly Thr His His Glu Lys Gly Ala Gln Thr Phe Trp Ser Val Val 
65                  70                  75                  80  


Asn Arg Leu Pro Leu Ser Ser Asn Ala Val Leu Cys Trp Lys Phe Cys 
                85                  90                  95      


His Val Phe His Lys Leu Leu Arg Asp Gly His Pro Asn Val Leu Lys 
            100                 105                 110         


Asp Ser Leu Arg Tyr Arg Asn Glu Leu Ser Asp Met Ser Arg Met Trp 
        115                 120                 125             


Gly His Leu Ser Glu Gly Tyr Gly Gln Leu Cys Ser Ile Tyr Leu Lys 
    130                 135                 140                 


Leu Leu Arg Thr Lys Met Glu Tyr His Thr Lys Asn Pro Arg Phe Pro 
145                 150                 155                 160 


Gly Asn Leu Gln Met Ser Asp Arg Gln Leu Asp Glu Ala Gly Glu Ser 
                165                 170                 175     


Asp Val Asn Asn Phe Phe Gln Leu Thr Val Glu Met Phe Asp Tyr Leu 
            180                 185                 190         


Glu Cys Glu Leu Asn Leu Phe Gln Thr Val Phe Asn Ser Leu Asp Met 
        195                 200                 205             


Ser Arg Ser Val Ser Val Thr Ala Ala Gly Gln Cys Arg Leu Ala Pro 
    210                 215                 220                 


Leu Ile Gln Val Ile Leu Asp Cys Ser His Leu Tyr Asp Tyr Thr Val 
225                 230                 235                 240 


Lys Leu Leu Phe Lys Leu His Ser Cys Leu Pro Ala Asp Thr Leu Gln 
                245                 250                 255     


Gly His Arg Asp Arg Phe Met Glu Gln Phe Thr Lys Leu Lys Asp Leu 
            260                 265                 270         


Phe Tyr Arg Ser Ser Asn Leu Gln Tyr Phe Lys Arg Leu Ile Gln Ile 
        275                 280                 285             


Pro Gln Leu Pro Glu Asn Pro Pro Asn Phe Leu Arg Ala Ser Ala Leu 
    290                 295                 300                 


Ser Glu His Ile Ser Pro Val Val Val Ile Pro Ala Glu Ala Ser Ser 
305                 310                 315                 320 


Pro Asp Ser Glu Pro Val Leu Glu Lys Asp Asp Leu Met Asp Met Asp 
                325                 330                 335     


Ala Ser Gln Gln Asn Leu Phe Asp Asn Lys Phe Asp Asp Ile Phe Gly 
            340                 345                 350         


Ser Ser Phe Ser Ser Asp Pro Phe Asn Phe Asn Ser Gln Asn Gly Val 
        355                 360                 365             


Asn Lys Asp Glu Lys Asp His Leu Ile Glu Arg Leu Tyr Arg Glu Ile 
    370                 375                 380                 


Ser Gly Leu Lys Ala Gln Leu Glu Asn Met Lys Thr Glu Ser Gln Arg 
385                 390                 395                 400 


Val Val Leu Gln Leu Lys Gly His Val Ser Glu Leu Glu Ala Asp Leu 
                405                 410                 415     


Ala Glu Gln Gln His Leu Arg Gln Gln Ala Ala Asp Asp Cys Glu Phe 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Leu Arg Arg Gln Arg Glu Asp Thr Glu 
        435                 440                 445             


Lys Ala Gln Arg Ser Leu Ser Glu Ile Glu Arg Lys Ala Gln Ala Asn 
    450                 455                 460                 


Glu Gln Arg Tyr Ser Lys Leu Lys Glu Lys Tyr Ser Glu Leu Val Gln 
465                 470                 475                 480 


Asn His Ala Asp Leu Leu Arg Lys Asn Ala Glu Val Thr Lys Gln Val 
                485                 490                 495     


Ser Met Ala Arg Gln Ala Gln Val Asp Leu Glu Arg Glu Lys Lys Glu 
            500                 505                 510         


Leu Glu Asp Ser Leu Glu Arg Ile Ser Asp Gln Gly Gln Arg Lys Thr 
        515                 520                 525             


Gln Glu Gln Leu Glu Val Leu Glu Ser Leu Lys Gln Glu Leu Ala Thr 
    530                 535                 540                 


Ser Gln Arg Glu Leu Gln Val Leu Gln Gly Ser Leu Glu Thr Ser Ala 
545                 550                 555                 560 


Gln Ser Glu Ala Asn Trp Ala Ala Glu Phe Ala Glu Leu Glu Lys Glu 
                565                 570                 575     


Arg Asp Ser Leu Val Ser Gly Ala Ala His Arg Glu Glu Glu Leu Ser 
            580                 585                 590         


Ala Leu Arg Lys Glu Leu Gln Asp Thr Gln Leu Lys Leu Ala Ser Thr 
        595                 600                 605             


Glu Glu Ser Met Cys Gln Leu Ala Lys Asp Gln Arg Lys Met Leu Leu 
    610                 615                 620                 


Val Gly Ser Arg Lys Ala Ala Glu Gln Val Ile Gln Asp Ala Leu Asn 
625                 630                 635                 640 


Gln Leu Glu Glu Pro Pro Leu Ile Ser Cys Ala Gly Ser Ala Asp His 
                645                 650                 655     


Leu Leu Ser Thr Val Thr Ser Ile Ser Ser Cys Ile Glu Gln Leu Glu 
            660                 665                 670         


Lys Ser Trp Ser Gln Tyr Leu Ala Cys Pro Glu Asp Ile Ser Gly Leu 
        675                 680                 685             


Leu His Ser Ile Thr Leu Leu Ala His Leu Thr Ser Asp Ala Ile Ala 
    690                 695                 700                 


His Gly Ala Thr Thr Cys Leu Arg Ala Pro Pro Glu Pro Ala Asp Ser 
705                 710                 715                 720 


Leu Thr Glu Ala Cys Lys Gln Tyr Gly Arg Glu Thr Leu Ala Tyr Leu 
                725                 730                 735     


Ala Ser Leu Glu Glu Glu Gly Ser Leu Glu Asn Ala Asp Ser Thr Ala 
            740                 745                 750         


Met Arg Asn Cys Leu Ser Lys Ile Lys Ala Ile Gly Glu Glu Leu Leu 
        755                 760                 765             


Pro Arg Gly Leu Asp Ile Lys Gln Glu Glu Leu Gly Asp Leu Val Asp 
    770                 775                 780                 


Lys Glu Met Ala Ala Thr Ser Ala Ala Ile Glu Thr Ala Thr Ala Arg 
785                 790                 795                 800 


Ile Glu Glu Met Leu Ser Lys Ser Arg Ala Gly Asp Thr Gly Val Lys 
                805                 810                 815     


Leu Glu Val Asn Glu Arg Ile Leu Gly Cys Cys Thr Ser Leu Met Gln 
            820                 825                 830         


Ala Ile Gln Val Leu Ile Val Ala Ser Lys Asp Leu Gln Arg Glu Ile 
        835                 840                 845             


Val Glu Ser Gly Arg Gly Thr Ala Ser Pro Lys Glu Phe Tyr Ala Lys 
    850                 855                 860                 


Asn Ser Arg Trp Thr Glu Gly Leu Ile Ser Ala Ser Lys Ala Val Gly 
865                 870                 875                 880 


Trp Gly Ala Thr Val Met Val Asp Ala Ala Asp Leu Val Val Gln Gly 
                885                 890                 895     


Arg Gly Lys Phe Glu Glu Leu Met Val Cys Ser His Glu Ile Ala Ala 
            900                 905                 910         


Ser Thr Ala Gln Leu Val Ala Ala Ser Lys Val Lys Ala Asp Lys Asp 
        915                 920                 925             


Ser Pro Asn Leu Ala Gln Leu Gln Gln Ala Ser Arg Gly Val Asn Gln 
    930                 935                 940                 


Ala Thr Ala Gly Val Val Ala Ser Thr Ile Ser Gly Lys Ser Gln Ile 
945                 950                 955                 960 


Glu Glu Thr Asp Asn Met Asp Phe Ser Ser Met Thr Leu Thr Gln Ile 
                965                 970                 975     


Lys Arg Gln Glu Met Asp Ser Gln Val Arg Val Leu Glu Leu Glu Asn 
            980                 985                 990         


Glu Leu Gln Lys Glu Arg Gln Lys  Leu Gly Glu Leu Arg  Lys Lys His 
        995                 1000                 1005             


Tyr Glu  Leu Ala Gly Val Ala  Glu Gly Trp Glu Glu  Gly Thr Glu 
    1010                 1015                 1020             


Ala Ser  Pro Pro Thr Leu Gln  Glu Val Val Thr Glu  Lys Glu 
    1025                 1030                 1035         


<210>  872
<211>  8522
<212>  DNA
<213>  Homo Sapiens

<400>  872
acttccggcg tatgaggcgg tgacaatggg agcagcgcgg gcggcgccgg gaggcagctg       60

acaagcgttt gcggcttcgc ttcatggccg ctctcccgcc cctcctggga tctgtgggga      120

gctggggagc ccgcagcggc ccggagccgg agctggcgag ccgagcggag acctgtgcgc      180

cgcgcctctg aggcgcagca tgtgaagcgg agacggcatc cagtgggggg cgagcctctc      240

agccggccgg gatggctacc acggccgagc tcttcgagga gccttttgtg gcagatgaat      300

atattgaacg tcttgtatgg agaaccccag gaggaggctc tagaggtgga cctgaagctt      360

ttgatcctaa aagattatta gaagaatttg taaatcatat tcaggaactc cagataatgg      420

atgaaaggat tcagaggaaa gtagagaaac tagagcaaca atgtcagaaa gaagccaagg      480

aatttgccaa gaaggtacaa gagctgcaga aaagcaatca ggttgccttc caacatttcc      540

aagaactaga tgagcacatt agctatgtag caactaaagt ctgtcacctt ggagaccagt      600

tagagggggt aaacacaccc agacaacggg cagtggaggc tcagaaattg atgaaatact      660

ttaatgagtt tctagatgga gaattgaaat ctgatgtttt tacaaattct gaaaagataa      720

aggaagcagc agacatcatt cagaagttgc acctaattgc ccaagagtta ccttttgata      780

gattttcaga agttaaatcc aaaattgcaa gtaaatacca tgatttagaa tgccagctga      840

ttcaggagtt taccagtgct caaagaagag gtgaaatctc cagaatgaga gaagtagcag      900

cagttttact tcattttaag ggttattccc attgtgttga tgtttatata aagcagtgcc      960

aggagggtgc ttatttgaga aatgatatat ttgaagacgc tggaatactc tgtcaaagag     1020

tgaacaaaca agttggagat atcttcagta atccagaaac agtcctggct aaacttattc     1080

aaaatgtatt tgaaatcaaa ctacagagtt ttgtgaaaga gcagttagaa gaatgtagga     1140

agtccgatgc agagcaatat ctcaaaaatc tctatgatct gtatacaaga accaccaatc     1200

tttccagcaa gctgatggag tttaatttag gtactgataa acagactttc ttgtctaagc     1260

ttatcaaatc cattttcatt tcctatttgg agaactatat tgaggtggag actggatatt     1320

tgaaaagcag aagtgctatg atcctacagc gctattatga ttcgaaaaac catcaaaaga     1380

gatccattgg cacaggaggt attcaagatt tgaaggaaag aattagacag cgtaccaact     1440

taccacttgg gccaagtatc gatactcatg gggagacttt tctatcccaa gaagtggtgg     1500

ttaatctttt acaagaaacc aaacaagcct ttgaaagatg tcataggctc tctgatcctt     1560

ctgacttacc aaggaatgcc ttcagaattt ttaccattct tgtggaattt ttatgtattg     1620

agcatattga ttatgctttg gaaacaggac ttgctggaat tccctcttca gattctagga     1680

atgcaaatct ttattttttg gacgttgtgc aacaggccaa tactattttt catctttttg     1740

acaaacagtt taatgatcac cttatgccac taataagctc ttctcctaag ttatctgaat     1800

gccttcagaa gaaaaaagaa ataattgaac aaatggagat gaaattggat actggcattg     1860

ataggacatt aaattgtatg attggacaga tgaagcatat tttggctgca gaacagaaga     1920

aaacagattt taagccagaa gatgaaaaca atgttttgat tcaatatact aatgcctgtg     1980

taaaagtctg tgcttacgta agaaaacaag tggagaagat taaaaattcc atggatggga     2040

agaatgtgga tacagttttg atggaacttg gagtacgttt tcatcgactt atctatgagc     2100

atcttcaaca atattcctac agttgtatgg gtggcatgtt ggccatttgt gatgtagccg     2160

aatataggaa gtgtgccaaa gacttcaaga ttccaatggt attacatctt tttgatactc     2220

tgcatgctct ttgcaatctt ctggtagttg ccccagataa tttaaagcaa gtctgctcag     2280

gagaacaact tgctaatctg gacaagaata tacttcactc cttcgtacaa cttcgtgctg     2340

attatagatc tgcccgcctt gctcgacact tcagctgaga ttgaatttac aaaggaattc     2400

agtgtcagtt cctttacaga ggaatgtctt atacttcagc agccctcggt tgatagaaag     2460

cacaggagat accttatgac acagccaaca ttttgtgaaa caatgactgg aacaaaacag     2520

cagccatact tacctttgag gttttattta aagtttggat accactagct atattttgct     2580

tttttcccct cacattgaat tttaattcca ttcttgaatg tagaaatttc agattctcta     2640

aaactacatg tcactgtttt tatcctagaa aatgttgctg tcagaaggca aaggaaatgt     2700

taccagtgtt ttcggttctt gtacttttaa catattccat ttagaaattt tgccattctg     2760

ttttccatta ataataggtg aaatacagga aaactacatt tgttattcct cagtttttaa     2820

tgaccttttc agcatcaatt gttaatcaga ttattttagg ttttcgtaaa taattttttt     2880

gcctctttca aaaggttaac aattaagcat actttctgca gttggttgat tggatttttt     2940

tctgaggtac agcattaata ctagtccaaa aaatgtcata aactgaacta aaatgatgaa     3000

ctattttatg tagacattag gagtggatcg gaatacttct gctttctggg taaaacttaa     3060

aagtttacta tttcttattt ggtaaataga ttttaagcca attctagtaa gaaattaata     3120

aaactacctt attttgtatt tcacttaagg tggaggacct taactaaagg accatattta     3180

ttcattattt taatattata agggaagtaa aaaaaagtga ggtatagtct aaatggtgca     3240

tataggaaat actgacagtg tttagcaaca tgcagccctt tgagatttct gtcgtaatgc     3300

taaacttgaa taagatggaa tggctgaaca tgtggttagt cttttatttt aagaagaatt     3360

gagaattgat agatttggag atgagctttg caaaggctgt ttgcttttca tgtctatagg     3420

tctgtcattg tcctttttca aagcatttct gaagttattc ctacttggat atagttaatg     3480

gaattggctt aatttgatga cataataaat cacttataaa attttaaata tcaagtgaaa     3540

atttagaaag gccattacta ttctataaac cttataaact tgctctggga gaatgcattc     3600

taaattatat atagtgtttc agctcccatt gtggtgttca tagtcttcta ggaacagata     3660

aacttaagta ttcaattcac tcttggcatt ttttctttaa tataggcttt ttagcctatt     3720

tttggaaaac tgcttttctt ctgagaacct tattctgaat gtcatcaact ttaccaaacc     3780

ttctaagtcc agagctaact tagtactgtt taagttacta ttgactgaat tttcttcatt     3840

ttctgtttag tccagtgtta ccaaggtaag ctggggaatg aagtatacca acttctttca     3900

gagcatttta ggacattatg gcagctttag aaggctgtct tgtttctagc caagggagag     3960

ccagcgcagg ttttggatac tagagaaagt catttgcttg tactattgcc attttagaaa     4020

gctctgatgt gaattcaaat tttacctctg ttacttaaag ccaacaattt taaggcagta     4080

gttttactgg ccatttaagc tctttgtaca gtgtcaattt gtaaaaaaga aaaaacgaaa     4140

aaaaatctca aataaaacat gagataacat tttaagactt ccaaatcaga gaagtgcttc     4200

aaattatttt gtttggatta atttttaaaa tgtaaagcat atacttgttg cttagttatt     4260

ttgtttatta ttttcatgtt tgagttctgt gcaatatttt ctattatgtc cgttgatagg     4320

acagtgacaa aattcgtaag tgaatactta atttaaaagt gttaacatta atgctcaata     4380

aacaaattcc ctgcagttgt tttttttatt tcactctttt tatattttag agccatccat     4440

cctgaatttt ataaatgatt ttttatttaa aaatttgaga tttttaaaat ttttcacagc     4500

acaggtcttc tcattttctt ttttagcaaa aaatacttga ctatataaac aagactagaa     4560

atttatccta aacagatggt ctttctctga gggaaaaaaa aaaatgtgtc atgtgaggca     4620

atatgcattc tttgtattct gattttttaa gtgttttcat atttatagcc atcacaaaat     4680

tttgcccaaa gtgtatggct cagaagagat gatcaataac taaaatgttt ttcgttttgc     4740

acatggtaaa attttaggta gagagtggag ctttgtataa ttggtaactt taaccaacat     4800

ttacgtaagt acggtctttg cagtattaca caataccgca tgagctaata tgcagtattt     4860

aggtaatgca ttgaatgaag ttgaaaatat gctcttaaca cactgtgcat tgtttttcta     4920

aaattgagaa atatctgaaa tacagaatac gaatttaata aaggaagcct accttatgta     4980

aattatgatg ttgaaaatga cagtcaacca gagtagatga agtgtcctta tgaagaatta     5040

ttaaatagta gctggatgga tctttagatg gatgaccacc tgaccattcc aggacaattt     5100

ttggtcccat tttgaggatt gccatagttg caagtcctta ggatcttcct tgttttaaaa     5160

aactatcaaa gtaggttaaa ttaaaatcta atttaaatta ggttaattta tattacattg     5220

tagatcattc ttttttcccc cctctttcac ttctaaatat tttgctttct aaatactagc     5280

cttctggttc acagtgaaat aatttaatta tcaatcagta gattgattcc aagtggagaa     5340

ttcactgctt ccctaaaatg cgtttttctt acctgtaatg gtgaatattt acaaggatct     5400

ggataaagag attttgattt ttgaaatgcc acaaaacccc ttaaagtggt caagtaccta     5460

aggtagtggc taaggcatgc ttgaactgtg tttgagagac agcagttcag tcagtacata     5520

atttgttggt gactaacaaa gctcacatct gggagattaa ctttttttaa cgcaaaaata     5580

ttctgcacat tacccatata ttgttgaatt ttacatacaa agcattttgt gctttcattc     5640

aattagttta actatattca gtttctgtat tatttctctc tgatctatcc tgtaattatt     5700

ctatacttta gaagaaaaga tcagttcata ttgttagact gaataattct acatgaagtt     5760

aaaagttagc aatttaaaaa attttgctgc ataataaaga taattatagt tacatgtatt     5820

gatttaagtc tcacacactg tgctaataag tcctttgcac atattattgg attctagagc     5880

aaccctagga tttgggtact attatttcca tttgacagat gaaaaaccta atgcatagaa     5940

agataagtag accagtcaag gtctacagct agtaaaatgc tcagattgaa acctaaatct     6000

tttctcactc acttttaggt tctatatgct attctcctta cgtaacgtta aatagatcct     6060

ttagtttgat aggttcatta gttttgctta atcgttgctt ccaatatgat tcttattgta     6120

gtatttatat tacaaagttg gcatacaggg tcaatatcta atttactgtt gtgtttttct     6180

taatatgttc aatgtatggt catacttttt aaatttgatt ttttaaatat tataagtggt     6240

catgaaattt taatgttaag tttgtaccta atagaaatat gtctatcaca aatctttatt     6300

ggtattattt tatatacttt tccagcttga taattttcac aatagaaaga gaccaaatat     6360

tttgtactat attttgtgac atagaagtaa atgacaactc taccttggaa gatatgaaga     6420

aatcagtgtt tttatgttca aaaactattt taaatgtcat aggcttgcca attgtgttaa     6480

ctatttagta cattggtagt ttttaaatga ctaatgctgg agtgaaaatg taaggcaaaa     6540

tatttagtat attaacagta gatagtcatt ttcatgtaat cagaattgca tgttaagggt     6600

tttaaaagct gtcataactc ttacctttta tttctaccag tgatcaatca tttctcttta     6660

caaatttagg gaggaaacaa ctgttcaaat gtatagggga cagaaacctg acatttagag     6720

aacagaaatt ttaattgcca aattaaagca gctaggctgc ccctgggctt aacaaaattc     6780

ctatttttga actagacccg aggtatttta tcattattat ttgataggta ccattaacct     6840

ttgttttgtg attatcgact tttgggggga aagatgagta attaaacaca ctcgcccatt     6900

ttctaagtgg tttagaaggt tgcagtctgc ctcaccatac aaagccagtt taaataggaa     6960

tatatcacat catacttcac atagcagtca acctcagagg aaagtcattt attcagaagg     7020

catagatttt gctagacagc agtgatgcat tacaaatata taattatttg cactaatatt     7080

tgagcaggtg gaatggatta gaacatggtc aacatcatgc tgctgataac atgtattttt     7140

ctatattaat atgtactgtg caacatgtat taaaattgtc aataattcat tttagccaag     7200

atactaatat ttatattact gtgtttaaga gacagtatcc aactgagcca cttttaattt     7260

aaaagtctga aactggaatt aagtttactt tcaaaaatca cttaaattac tttataatca     7320

gtgaaaggtc agtaaaatgt agaattataa gtgcctagtg acttaatagg aggaaatatg     7380

gagggttaag gaaggaagta ggaacctgga ataagaaagc taagtttcat ttatagttcc     7440

aatgagtgac tttctttgtt ttcaccactg ggaatcttaa atgaagaaag tgtcgtatcc     7500

cttccagtta tctttatgtt aataaactaa gtgaagtttg gatagaacta acaaaggaat     7560

tagtctccat tggtggactt ccagagtttt gagattaaac tttgagaggt gagaagcctt     7620

cctgatgccc ctgtaatctt aaattggcag gtgcctctaa gtgaggccat ccctctttgc     7680

ctgcctatca ttttaatctt tatactgtaa ctggttcctt tcaactctgg ccttttattg     7740

tagcactttt atcaagtctg cagcttccca gctacttggg aggctgaggt gggaagaaca     7800

cttgaagcta ggagttcaag accactctgg gcaacatagt gagtccctgt ttttagaaaa     7860

ataaataacc tttaggtttt tgctatagaa aatatccaaa tagagtctgg acaatgctgg     7920

atgtaaagaa aactgtgaag ctacctctaa gcatattgtt tgtgaatact gtgtaccatt     7980

tagaggataa catgggggat tcacatgaag ttatgtgaaa atattttata aggaataata     8040

cctaagtgcc tctcttaagt tctccagtag aatgtatttt caatttttgc cacaaggggg     8100

agaagttatt tttatagtaa tatgtacatt tttttatttt aaaaatagaa ttcacacaac     8160

tttacagcat ctatgaacat tttgctatcc caattatgtg tgtgtgtgca tgtgtgtaaa     8220

caagattctg aaagtcttgc atgagaaaaa tttcaaagga aattaataac aaaaccaaaa     8280

cagttttgaa gaacatgtgc acagtggaca caggaattga acaaagttta ccatgattaa     8340

cattatgttt tcttagttat atatcacatt gaattccttt atcaactcta ataagaatct     8400

actgattagt gttctacatt ctgcttttta aagaaaaatt tttgaaacaa tcagacttaa     8460

cagaagggtt gtaaatactg tacaaataaa atttttccct tttgagaata aaaaaaaaaa     8520

aa                                                                    8522


<210>  873
<211>  708
<212>  PRT
<213>  Homo Sapiens

<400>  873

Met Ala Thr Thr Ala Glu Leu Phe Glu Glu Pro Phe Val Ala Asp Glu 
1               5                   10                  15      


Tyr Ile Glu Arg Leu Val Trp Arg Thr Pro Gly Gly Gly Ser Arg Gly 
            20                  25                  30          


Gly Pro Glu Ala Phe Asp Pro Lys Arg Leu Leu Glu Glu Phe Val Asn 
        35                  40                  45              


His Ile Gln Glu Leu Gln Ile Met Asp Glu Arg Ile Gln Arg Lys Val 
    50                  55                  60                  


Glu Lys Leu Glu Gln Gln Cys Gln Lys Glu Ala Lys Glu Phe Ala Lys 
65                  70                  75                  80  


Lys Val Gln Glu Leu Gln Lys Ser Asn Gln Val Ala Phe Gln His Phe 
                85                  90                  95      


Gln Glu Leu Asp Glu His Ile Ser Tyr Val Ala Thr Lys Val Cys His 
            100                 105                 110         


Leu Gly Asp Gln Leu Glu Gly Val Asn Thr Pro Arg Gln Arg Ala Val 
        115                 120                 125             


Glu Ala Gln Lys Leu Met Lys Tyr Phe Asn Glu Phe Leu Asp Gly Glu 
    130                 135                 140                 


Leu Lys Ser Asp Val Phe Thr Asn Ser Glu Lys Ile Lys Glu Ala Ala 
145                 150                 155                 160 


Asp Ile Ile Gln Lys Leu His Leu Ile Ala Gln Glu Leu Pro Phe Asp 
                165                 170                 175     


Arg Phe Ser Glu Val Lys Ser Lys Ile Ala Ser Lys Tyr His Asp Leu 
            180                 185                 190         


Glu Cys Gln Leu Ile Gln Glu Phe Thr Ser Ala Gln Arg Arg Gly Glu 
        195                 200                 205             


Ile Ser Arg Met Arg Glu Val Ala Ala Val Leu Leu His Phe Lys Gly 
    210                 215                 220                 


Tyr Ser His Cys Val Asp Val Tyr Ile Lys Gln Cys Gln Glu Gly Ala 
225                 230                 235                 240 


Tyr Leu Arg Asn Asp Ile Phe Glu Asp Ala Gly Ile Leu Cys Gln Arg 
                245                 250                 255     


Val Asn Lys Gln Val Gly Asp Ile Phe Ser Asn Pro Glu Thr Val Leu 
            260                 265                 270         


Ala Lys Leu Ile Gln Asn Val Phe Glu Ile Lys Leu Gln Ser Phe Val 
        275                 280                 285             


Lys Glu Gln Leu Glu Glu Cys Arg Lys Ser Asp Ala Glu Gln Tyr Leu 
    290                 295                 300                 


Lys Asn Leu Tyr Asp Leu Tyr Thr Arg Thr Thr Asn Leu Ser Ser Lys 
305                 310                 315                 320 


Leu Met Glu Phe Asn Leu Gly Thr Asp Lys Gln Thr Phe Leu Ser Lys 
                325                 330                 335     


Leu Ile Lys Ser Ile Phe Ile Ser Tyr Leu Glu Asn Tyr Ile Glu Val 
            340                 345                 350         


Glu Thr Gly Tyr Leu Lys Ser Arg Ser Ala Met Ile Leu Gln Arg Tyr 
        355                 360                 365             


Tyr Asp Ser Lys Asn His Gln Lys Arg Ser Ile Gly Thr Gly Gly Ile 
    370                 375                 380                 


Gln Asp Leu Lys Glu Arg Ile Arg Gln Arg Thr Asn Leu Pro Leu Gly 
385                 390                 395                 400 


Pro Ser Ile Asp Thr His Gly Glu Thr Phe Leu Ser Gln Glu Val Val 
                405                 410                 415     


Val Asn Leu Leu Gln Glu Thr Lys Gln Ala Phe Glu Arg Cys His Arg 
            420                 425                 430         


Leu Ser Asp Pro Ser Asp Leu Pro Arg Asn Ala Phe Arg Ile Phe Thr 
        435                 440                 445             


Ile Leu Val Glu Phe Leu Cys Ile Glu His Ile Asp Tyr Ala Leu Glu 
    450                 455                 460                 


Thr Gly Leu Ala Gly Ile Pro Ser Ser Asp Ser Arg Asn Ala Asn Leu 
465                 470                 475                 480 


Tyr Phe Leu Asp Val Val Gln Gln Ala Asn Thr Ile Phe His Leu Phe 
                485                 490                 495     


Asp Lys Gln Phe Asn Asp His Leu Met Pro Leu Ile Ser Ser Ser Pro 
            500                 505                 510         


Lys Leu Ser Glu Cys Leu Gln Lys Lys Lys Glu Ile Ile Glu Gln Met 
        515                 520                 525             


Glu Met Lys Leu Asp Thr Gly Ile Asp Arg Thr Leu Asn Cys Met Ile 
    530                 535                 540                 


Gly Gln Met Lys His Ile Leu Ala Ala Glu Gln Lys Lys Thr Asp Phe 
545                 550                 555                 560 


Lys Pro Glu Asp Glu Asn Asn Val Leu Ile Gln Tyr Thr Asn Ala Cys 
                565                 570                 575     


Val Lys Val Cys Ala Tyr Val Arg Lys Gln Val Glu Lys Ile Lys Asn 
            580                 585                 590         


Ser Met Asp Gly Lys Asn Val Asp Thr Val Leu Met Glu Leu Gly Val 
        595                 600                 605             


Arg Phe His Arg Leu Ile Tyr Glu His Leu Gln Gln Tyr Ser Tyr Ser 
    610                 615                 620                 


Cys Met Gly Gly Met Leu Ala Ile Cys Asp Val Ala Glu Tyr Arg Lys 
625                 630                 635                 640 


Cys Ala Lys Asp Phe Lys Ile Pro Met Val Leu His Leu Phe Asp Thr 
                645                 650                 655     


Leu His Ala Leu Cys Asn Leu Leu Val Val Ala Pro Asp Asn Leu Lys 
            660                 665                 670         


Gln Val Cys Ser Gly Glu Gln Leu Ala Asn Leu Asp Lys Asn Ile Leu 
        675                 680                 685             


His Ser Phe Val Gln Leu Arg Ala Asp Tyr Arg Ser Ala Arg Leu Ala 
    690                 695                 700                 


Arg His Phe Ser 
705             


<210>  874
<211>  6409
<212>  DNA
<213>  Homo Sapiens

<400>  874
agaggaacag ggcaaacctc tgacttccgg cggcattttg aggcggtcct cctagcggcc       60

tgtagtacaa aatgtcaaaa attagaagga aggtcacagt ggaaaatacc aagactatat      120

ctgatagcac atcccgaaga cccagtgtat ttgagaggct tggacccagc actggcagta      180

cagcagagac acagtgccgt aactggctga agactggcaa ctgcctctat ggaaacacat      240

gtagattcgt acatggccct tcacctcgtg gtaaaggtta tagcagcaat tatagaaggt      300

caccagaaag acctacaggg gatcttagag aaagaatgaa gaacaagcgc caagacgtgg      360

acactgagcc ccagaaacga aatacagagg agtcatcctc acctgttagg aaagaatctt      420

caagagggag acatagggaa aaggaagaca taaaaatcac taaggaaaga actccagaaa      480

gtgaagaaga aaatgtagaa tgggaaacta atagagatga ttctgacaat ggagatatta      540

attatgatta tgttcatgaa ttgtcattgg aaatgaagcg tcagaagata cagagggaat      600

taatgaagct ggaacaagaa aacatggaga agagagaaga aattatcatt aaaaaggagg      660

tttcaccaga agtggttaga tcaaaattgt ccccgtcacc ttctctaaga aagtctagca      720

aatctccgaa gcgaaaatca agcccgaagt cgtcttcagc tagcaagaaa gataggaaga      780

catctgcagt atcttctccc ctgttggacc agcagagaaa ttcaaaaacc aaccaaagta      840

aaaagaaagg accacgtact cctagtccac cccctcctat accagaagat atcgctctgg      900

ggaaaaaata caaagaaaaa tataaagtaa aagacaggat agaagaaaaa acaagagatg      960

gaaaggacag aggacgagat tttgaacgac aaagagaaaa gagagacaag ccaaggtcta     1020

cttccccagc aggacagcat cattctccta tatcttctag acatcactca tcttcctcac     1080

aatcaggatc atctattcaa agacattctc cttctcctcg tcgaaaaaga actccttcac     1140

catcttatca gcggacacta actccacctt tacgacgctc tgcctctcct tatccttcac     1200

attctttgtc gtctccccag agaaagcaga gtcctccaag acatcgctct ccaatgcgag     1260

agaaagggag acatgatcat gaacgaactt cacagtctca tgatcgacgc catgaaagga     1320

gggaagatac taggggcaaa cgagacagag aaaaggactc aagagaagaa cgagaatatg     1380

aacaggatca gagctcttct agagaccaca gagatgacag agaacctcga gatggtcggg     1440

atcggagaga tgccagagat actagggacc gaagggaact aagagactcc agagacatgc     1500

gggactcaag ggagatgaga gattatagca gagataccaa agagagccgt gatcccagag     1560

attctcggtc cactcgtgat gcccatgact acagggaccg tgaaggtcga gatactcatc     1620

gaaaggagga tacatatcca gaagaatccc ggagttatgg ccgaaaccat ttgagagaag     1680

aaagttctcg tacggaaata aggaatgagt ccagaaatga gtctcgaagt gaaattagaa     1740

atgaccgaat gggccgaagt agggggaggg ttcctgagtt acctgaaaag ggaagtcgag     1800

gctcaagagg ttctcaaatt gatagtcaca gtagtaatag caactatcat gacagctggg     1860

aaactcgaag tagctatcct gaaagagata gatatcctga aagagacaac agagatcaag     1920

caagggattc ttcctttgag agaagacatg gagagcgaga ccgtcgtgac aacagagaga     1980

gagatcaaag accaagctca ccaattcgac atcagggaag gaatgacgag cttgagcgtg     2040

atgaaagaag agaggaacga agagtagaca gagtggatga taggagagat gaaagggcta     2100

gagagagaga tcgggaacga gaacgagaca gggagcggga gagagagagg gaacgtgaac     2160

gggatcggga aagagaaaaa gagagagaac tagaaagaga gcgtgctagg gaacgggaga     2220

gagaaagaga aaaagagaga gatcgtgaaa gggatagaga ccgagaccac gatcgagagc     2280

gggaaagaga gagggaacga gacagggaaa aagaacggga acgagaaaga gaagagagag     2340

agagggagag agagcgagaa cgggagagag agcgagagcg agaacgggaa cgagaaagag     2400

cgagagaaag ggataaagaa cgagaacgcc aaagggattg ggaagacaaa gacaaaggac     2460

gagatgaccg cagagaaaag cgagaagaga tccgagaaga taggaatcca agagatggac     2520

atgatgaaag aaaatcaaag aagcgctata gaaatgaagg gagtcccagc cctagacagt     2580

ccccgaagcg ccggcgtgaa cattctccgg acagtgatgc ctacaacagt ggagatgata     2640

aaaatgaaaa acacagactc ttgagccaag ttgtacgacc tcaagaatct cgttctctta     2700

gtccctcgca cctcacagaa gacagacagg gtagatggaa agaggaggat cgtaaaccag     2760

aaaggaaaga gagttcaagg cgctacgaag aacaggaact caaggagaaa gtttcttctg     2820

tagataaaca gagagaacag acagaaatcc tggaaagctc aagaatgcgt gcacaggaca     2880

ttataggaca ccaccagtct gaagatcgag agacatctga tcgagctcat gatgaaaaca     2940

agaagaaagc aaaaattcaa aagaaaccaa ttaagaaaaa gaaagaggat gatgttggaa     3000

tagagagggg taacatagag acaacatctg aagatggtca agtattttca ccaaaaaaag     3060

gacagaaaaa gaaaagcatt gaaaaaaaac gtaaaaaatc caaaggtgat tctgatattt     3120

ctgatgaaga agcagcccag caaagtaaga agaaaagagg cccacggact ccccctataa     3180

caactaaaga ggaattggtt gaaatgtgca atggtaagaa tggtattcta gaggactccc     3240

agaaaaaaga agatacagca ttcagtgact ggtctgatga ggatgtccct gaccgtacag     3300

aggtgacaga agcagagcat actgccaccg ccacgactcc tggtagtacc ccttctcctc     3360

tatcttctct tcttcctcct ccaccgcctg tggctactgc cactgctaca actgtgcctg     3420

caactcttgc tgccactact gctgctgccg ccacctcttt cagcacatct gccatcacta     3480

tttccacctc tgccaccccc accaatacca ccaataatac ttttgccaat gaagactcac     3540

acagaaaatg ccacagaaca cgagtagaaa aagtagagac gcctcacgtg actatagaag     3600

atgcacagca tcgcaagcct atggatcaaa agaggagcag cagcctcggg agcaatcgga     3660

gtaaccgtag tcatacgtct ggtcgtcttc gctccccatc caatgattca gcccatcgaa     3720

gtggagatga ccaaagtggt cgaaagagag tactgcacag tggctcaaga gatagagaaa     3780

aaacaaaaag cctggaaatc acaggagaga gaaaatctag gattgatcag ttaaagcgtg     3840

gagaacccag tcgaagtact tcttcagatc gccaggattc aagaagccat agttcaagaa     3900

gaagttctcc agagtcagat cgacaggtcc attcaagatc tgggtcattt gatagcagag     3960

acaggcttca agaacgagat cgatatgaac acgacagaga gcgcgagaga gagaggagag     4020

atacgaggca gagagaatgg gaccgagatg ctgataaaga ttggccacgc aacagggatc     4080

gagatagatt gcgagaacga gaacgagaga gagaacgaga caaaaggaga gacttggata     4140

gggaaagaga gagactaatt tctgattctg ttgaaaggga cagggacaga gacagagaca     4200

gaacttttga gagttctcaa atagagtctg tgaaacgctg tgaagcaaaa ctggaaggtg     4260

aacatgaaag ggatctagaa agcacttccc gagactctct agccttggat aaagagagaa     4320

tggataaaga tctgggatct gtgcagggat ttgaagaaac aaataaatcc gagagaactg     4380

agagtctgga agcaggagat gacgagtcca agttagatga tgcacattca ttaggctctg     4440

gtgctggaga aggatacgag ccaatcagtg atgacgaact agatgaaatt ctggcaggtg     4500

atgcagaaaa gagggaggac caacaggatg aggagaagat gccagatccc ttagatgtga     4560

tagatgtgga ttggtctggt cttatgccaa agcatccaaa agaaccacga gagcctgggg     4620

ctgcactctt aaaattcaca cctggagctg ttatgctaag agttgggatt tctaaaaagt     4680

tggcaggttc tgaactcttt gccaaagtca aagaaacatg tcagagactt ttagaaaaac     4740

ccaaaggtag tttcatttta ctttaactat ataatgtctg ttaaccattt aagatgccat     4800

ctgaagggga ttctgatctg ttcttatgta gcacttaaca ctgtgtagaa actatttttt     4860

gagaaatcat tttataatca ttatttaacc ctcatggtca aagtttctct ttaaaattta     4920

ttttgagaag aagagttatc ccacagaaaa gttgggaaaa gagtacaatg acctttttgt     4980

atgaaaatta cttattaaca ggccaggcgt ggtgttgcat gtctgtagtc acagctactc     5040

agggaggttg aggcagcagg attgctggag cccaggaaat tgaggctgca gtgagccatg     5100

attgagccac cacactccaa cctaggtgac agagcaagac cctgtctcaa aaaaaaaaaa     5160

acaaattaac caataagttc taatatcaaa gtgctcagtg gtttgccctt ggctaaatga     5220

agcagagcca ggaaaaacag actacatatt tttcatgtct aaagaaattg ggtattttgg     5280

cagccctttc ccctagacat ctacccaaat gcaggtgtgt aggttgagtc tttaacaaag     5340

tgattaagag cttggtctgt aaggccggat gatctggatt tcagtaggca caccacttac     5400

tggctattac ttaatctgtg tgttagtgtc atcatctgta agtcaggaat aatcatacca     5460

ccaacttcct atggtaatta ggagcaaatg agttattaca ggcaaaacac ttagaacagt     5520

tcctggcata tagtaatacc caataaatat taactgctac tttgaaaata tcctatcacg     5580

ctgatttttg acctcactgc agcaattttc agttattcca gattatctag cttatggatt     5640

ctggtggtag gggttgtttg gttttggttt tcactgtctc tgtctcatct agtacctacc     5700

ttagtttatt ttgcaactta ctaatacttt attaatgggg agggacgagt agatggtaaa     5760

aagaaggaaa aggaggtaaa aggtgaaagg aacaacatta attaacaatt ttacgtcatg     5820

tccctggaca taaaagttta gttagtatta aatttttcac taatacaaaa taaaaaaata     5880

ttgttttatg agttttatga attcatgccc ttcctttact ctattagcat aagcagtaaa     5940

tttttttatt ttaatatagc ccaataaacc tagagtatac atgtacaaaa tacatataat     6000

tgttaacgtg tattaaccga aaaatgaccc aagacttagt tcttgcccta ctgtatctgc     6060

cttgtttggt tggttctgtg accttaagca aataactcct gtgagcctca attttatttg     6120

taaagtgatg gaataaaacc cctaaaatct tacccacctc taaagatatt tgtttctgtg     6180

accttttgct agtagcattt caagttaaaa tctggtttga ttttgctacc catgaaatac     6240

agttcggccc ttacttattg atgacttaac ctaaacagtg aaaatatgca ctgtaaaggg     6300

tggggtgatg tggcttaaca atcagacttc ttctattttt gctgctatgg tggttgtatt     6360

agagaactga tgtattatct tgaataaaga ctttgtcttg tttactgcc                 6409


<210>  875
<211>  1564
<212>  PRT
<213>  Homo Sapiens

<400>  875

Met Ser Lys Ile Arg Arg Lys Val Thr Val Glu Asn Thr Lys Thr Ile 
1               5                   10                  15      


Ser Asp Ser Thr Ser Arg Arg Pro Ser Val Phe Glu Arg Leu Gly Pro 
            20                  25                  30          


Ser Thr Gly Ser Thr Ala Glu Thr Gln Cys Arg Asn Trp Leu Lys Thr 
        35                  40                  45              


Gly Asn Cys Leu Tyr Gly Asn Thr Cys Arg Phe Val His Gly Pro Ser 
    50                  55                  60                  


Pro Arg Gly Lys Gly Tyr Ser Ser Asn Tyr Arg Arg Ser Pro Glu Arg 
65                  70                  75                  80  


Pro Thr Gly Asp Leu Arg Glu Arg Met Lys Asn Lys Arg Gln Asp Val 
                85                  90                  95      


Asp Thr Glu Pro Gln Lys Arg Asn Thr Glu Glu Ser Ser Ser Pro Val 
            100                 105                 110         


Arg Lys Glu Ser Ser Arg Gly Arg His Arg Glu Lys Glu Asp Ile Lys 
        115                 120                 125             


Ile Thr Lys Glu Arg Thr Pro Glu Ser Glu Glu Glu Asn Val Glu Trp 
    130                 135                 140                 


Glu Thr Asn Arg Asp Asp Ser Asp Asn Gly Asp Ile Asn Tyr Asp Tyr 
145                 150                 155                 160 


Val His Glu Leu Ser Leu Glu Met Lys Arg Gln Lys Ile Gln Arg Glu 
                165                 170                 175     


Leu Met Lys Leu Glu Gln Glu Asn Met Glu Lys Arg Glu Glu Ile Ile 
            180                 185                 190         


Ile Lys Lys Glu Val Ser Pro Glu Val Val Arg Ser Lys Leu Ser Pro 
        195                 200                 205             


Ser Pro Ser Leu Arg Lys Ser Ser Lys Ser Pro Lys Arg Lys Ser Ser 
    210                 215                 220                 


Pro Lys Ser Ser Ser Ala Ser Lys Lys Asp Arg Lys Thr Ser Ala Val 
225                 230                 235                 240 


Ser Ser Pro Leu Leu Asp Gln Gln Arg Asn Ser Lys Thr Asn Gln Ser 
                245                 250                 255     


Lys Lys Lys Gly Pro Arg Thr Pro Ser Pro Pro Pro Pro Ile Pro Glu 
            260                 265                 270         


Asp Ile Ala Leu Gly Lys Lys Tyr Lys Glu Lys Tyr Lys Val Lys Asp 
        275                 280                 285             


Arg Ile Glu Glu Lys Thr Arg Asp Gly Lys Asp Arg Gly Arg Asp Phe 
    290                 295                 300                 


Glu Arg Gln Arg Glu Lys Arg Asp Lys Pro Arg Ser Thr Ser Pro Ala 
305                 310                 315                 320 


Gly Gln His His Ser Pro Ile Ser Ser Arg His His Ser Ser Ser Ser 
                325                 330                 335     


Gln Ser Gly Ser Ser Ile Gln Arg His Ser Pro Ser Pro Arg Arg Lys 
            340                 345                 350         


Arg Thr Pro Ser Pro Ser Tyr Gln Arg Thr Leu Thr Pro Pro Leu Arg 
        355                 360                 365             


Arg Ser Ala Ser Pro Tyr Pro Ser His Ser Leu Ser Ser Pro Gln Arg 
    370                 375                 380                 


Lys Gln Ser Pro Pro Arg His Arg Ser Pro Met Arg Glu Lys Gly Arg 
385                 390                 395                 400 


His Asp His Glu Arg Thr Ser Gln Ser His Asp Arg Arg His Glu Arg 
                405                 410                 415     


Arg Glu Asp Thr Arg Gly Lys Arg Asp Arg Glu Lys Asp Ser Arg Glu 
            420                 425                 430         


Glu Arg Glu Tyr Glu Gln Asp Gln Ser Ser Ser Arg Asp His Arg Asp 
        435                 440                 445             


Asp Arg Glu Pro Arg Asp Gly Arg Asp Arg Arg Asp Ala Arg Asp Thr 
    450                 455                 460                 


Arg Asp Arg Arg Glu Leu Arg Asp Ser Arg Asp Met Arg Asp Ser Arg 
465                 470                 475                 480 


Glu Met Arg Asp Tyr Ser Arg Asp Thr Lys Glu Ser Arg Asp Pro Arg 
                485                 490                 495     


Asp Ser Arg Ser Thr Arg Asp Ala His Asp Tyr Arg Asp Arg Glu Gly 
            500                 505                 510         


Arg Asp Thr His Arg Lys Glu Asp Thr Tyr Pro Glu Glu Ser Arg Ser 
        515                 520                 525             


Tyr Gly Arg Asn His Leu Arg Glu Glu Ser Ser Arg Thr Glu Ile Arg 
    530                 535                 540                 


Asn Glu Ser Arg Asn Glu Ser Arg Ser Glu Ile Arg Asn Asp Arg Met 
545                 550                 555                 560 


Gly Arg Ser Arg Gly Arg Val Pro Glu Leu Pro Glu Lys Gly Ser Arg 
                565                 570                 575     


Gly Ser Arg Gly Ser Gln Ile Asp Ser His Ser Ser Asn Ser Asn Tyr 
            580                 585                 590         


His Asp Ser Trp Glu Thr Arg Ser Ser Tyr Pro Glu Arg Asp Arg Tyr 
        595                 600                 605             


Pro Glu Arg Asp Asn Arg Asp Gln Ala Arg Asp Ser Ser Phe Glu Arg 
    610                 615                 620                 


Arg His Gly Glu Arg Asp Arg Arg Asp Asn Arg Glu Arg Asp Gln Arg 
625                 630                 635                 640 


Pro Ser Ser Pro Ile Arg His Gln Gly Arg Asn Asp Glu Leu Glu Arg 
                645                 650                 655     


Asp Glu Arg Arg Glu Glu Arg Arg Val Asp Arg Val Asp Asp Arg Arg 
            660                 665                 670         


Asp Glu Arg Ala Arg Glu Arg Asp Arg Glu Arg Glu Arg Asp Arg Glu 
        675                 680                 685             


Arg Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Glu Arg Glu Lys Glu 
    690                 695                 700                 


Arg Glu Leu Glu Arg Glu Arg Ala Arg Glu Arg Glu Arg Glu Arg Glu 
705                 710                 715                 720 


Lys Glu Arg Asp Arg Glu Arg Asp Arg Asp Arg Asp His Asp Arg Glu 
                725                 730                 735     


Arg Glu Arg Glu Arg Glu Arg Asp Arg Glu Lys Glu Arg Glu Arg Glu 
            740                 745                 750         


Arg Glu Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
        755                 760                 765             


Glu Arg Glu Arg Glu Arg Glu Arg Ala Arg Glu Arg Asp Lys Glu Arg 
    770                 775                 780                 


Glu Arg Gln Arg Asp Trp Glu Asp Lys Asp Lys Gly Arg Asp Asp Arg 
785                 790                 795                 800 


Arg Glu Lys Arg Glu Glu Ile Arg Glu Asp Arg Asn Pro Arg Asp Gly 
                805                 810                 815     


His Asp Glu Arg Lys Ser Lys Lys Arg Tyr Arg Asn Glu Gly Ser Pro 
            820                 825                 830         


Ser Pro Arg Gln Ser Pro Lys Arg Arg Arg Glu His Ser Pro Asp Ser 
        835                 840                 845             


Asp Ala Tyr Asn Ser Gly Asp Asp Lys Asn Glu Lys His Arg Leu Leu 
    850                 855                 860                 


Ser Gln Val Val Arg Pro Gln Glu Ser Arg Ser Leu Ser Pro Ser His 
865                 870                 875                 880 


Leu Thr Glu Asp Arg Gln Gly Arg Trp Lys Glu Glu Asp Arg Lys Pro 
                885                 890                 895     


Glu Arg Lys Glu Ser Ser Arg Arg Tyr Glu Glu Gln Glu Leu Lys Glu 
            900                 905                 910         


Lys Val Ser Ser Val Asp Lys Gln Arg Glu Gln Thr Glu Ile Leu Glu 
        915                 920                 925             


Ser Ser Arg Met Arg Ala Gln Asp Ile Ile Gly His His Gln Ser Glu 
    930                 935                 940                 


Asp Arg Glu Thr Ser Asp Arg Ala His Asp Glu Asn Lys Lys Lys Ala 
945                 950                 955                 960 


Lys Ile Gln Lys Lys Pro Ile Lys Lys Lys Lys Glu Asp Asp Val Gly 
                965                 970                 975     


Ile Glu Arg Gly Asn Ile Glu Thr Thr Ser Glu Asp Gly Gln Val Phe 
            980                 985                 990         


Ser Pro Lys Lys Gly Gln Lys Lys  Lys Ser Ile Glu Lys  Lys Arg Lys 
        995                 1000                 1005             


Lys Ser  Lys Gly Asp Ser Asp  Ile Ser Asp Glu Glu  Ala Ala Gln 
    1010                 1015                 1020             


Gln Ser  Lys Lys Lys Arg Gly  Pro Arg Thr Pro Pro  Ile Thr Thr 
    1025                 1030                 1035             


Lys Glu  Glu Leu Val Glu Met  Cys Asn Gly Lys Asn  Gly Ile Leu 
    1040                 1045                 1050             


Glu Asp  Ser Gln Lys Lys Glu  Asp Thr Ala Phe Ser  Asp Trp Ser 
    1055                 1060                 1065             


Asp Glu  Asp Val Pro Asp Arg  Thr Glu Val Thr Glu  Ala Glu His 
    1070                 1075                 1080             


Thr Ala  Thr Ala Thr Thr Pro  Gly Ser Thr Pro Ser  Pro Leu Ser 
    1085                 1090                 1095             


Ser Leu  Leu Pro Pro Pro Pro  Pro Val Ala Thr Ala  Thr Ala Thr 
    1100                 1105                 1110             


Thr Val  Pro Ala Thr Leu Ala  Ala Thr Thr Ala Ala  Ala Ala Thr 
    1115                 1120                 1125             


Ser Phe  Ser Thr Ser Ala Ile  Thr Ile Ser Thr Ser  Ala Thr Pro 
    1130                 1135                 1140             


Thr Asn  Thr Thr Asn Asn Thr  Phe Ala Asn Glu Asp  Ser His Arg 
    1145                 1150                 1155             


Lys Cys  His Arg Thr Arg Val  Glu Lys Val Glu Thr  Pro His Val 
    1160                 1165                 1170             


Thr Ile  Glu Asp Ala Gln His  Arg Lys Pro Met Asp  Gln Lys Arg 
    1175                 1180                 1185             


Ser Ser  Ser Leu Gly Ser Asn  Arg Ser Asn Arg Ser  His Thr Ser 
    1190                 1195                 1200             


Gly Arg  Leu Arg Ser Pro Ser  Asn Asp Ser Ala His  Arg Ser Gly 
    1205                 1210                 1215             


Asp Asp  Gln Ser Gly Arg Lys  Arg Val Leu His Ser  Gly Ser Arg 
    1220                 1225                 1230             


Asp Arg  Glu Lys Thr Lys Ser  Leu Glu Ile Thr Gly  Glu Arg Lys 
    1235                 1240                 1245             


Ser Arg  Ile Asp Gln Leu Lys  Arg Gly Glu Pro Ser  Arg Ser Thr 
    1250                 1255                 1260             


Ser Ser  Asp Arg Gln Asp Ser  Arg Ser His Ser Ser  Arg Arg Ser 
    1265                 1270                 1275             


Ser Pro  Glu Ser Asp Arg Gln  Val His Ser Arg Ser  Gly Ser Phe 
    1280                 1285                 1290             


Asp Ser  Arg Asp Arg Leu Gln  Glu Arg Asp Arg Tyr  Glu His Asp 
    1295                 1300                 1305             


Arg Glu  Arg Glu Arg Glu Arg  Arg Asp Thr Arg Gln  Arg Glu Trp 
    1310                 1315                 1320             


Asp Arg  Asp Ala Asp Lys Asp  Trp Pro Arg Asn Arg  Asp Arg Asp 
    1325                 1330                 1335             


Arg Leu  Arg Glu Arg Glu Arg  Glu Arg Glu Arg Asp  Lys Arg Arg 
    1340                 1345                 1350             


Asp Leu  Asp Arg Glu Arg Glu  Arg Leu Ile Ser Asp  Ser Val Glu 
    1355                 1360                 1365             


Arg Asp  Arg Asp Arg Asp Arg  Asp Arg Thr Phe Glu  Ser Ser Gln 
    1370                 1375                 1380             


Ile Glu  Ser Val Lys Arg Cys  Glu Ala Lys Leu Glu  Gly Glu His 
    1385                 1390                 1395             


Glu Arg  Asp Leu Glu Ser Thr  Ser Arg Asp Ser Leu  Ala Leu Asp 
    1400                 1405                 1410             


Lys Glu  Arg Met Asp Lys Asp  Leu Gly Ser Val Gln  Gly Phe Glu 
    1415                 1420                 1425             


Glu Thr  Asn Lys Ser Glu Arg  Thr Glu Ser Leu Glu  Ala Gly Asp 
    1430                 1435                 1440             


Asp Glu  Ser Lys Leu Asp Asp  Ala His Ser Leu Gly  Ser Gly Ala 
    1445                 1450                 1455             


Gly Glu  Gly Tyr Glu Pro Ile  Ser Asp Asp Glu Leu  Asp Glu Ile 
    1460                 1465                 1470             


Leu Ala  Gly Asp Ala Glu Lys  Arg Glu Asp Gln Gln  Asp Glu Glu 
    1475                 1480                 1485             


Lys Met  Pro Asp Pro Leu Asp  Val Ile Asp Val Asp  Trp Ser Gly 
    1490                 1495                 1500             


Leu Met  Pro Lys His Pro Lys  Glu Pro Arg Glu Pro  Gly Ala Ala 
    1505                 1510                 1515             


Leu Leu  Lys Phe Thr Pro Gly  Ala Val Met Leu Arg  Val Gly Ile 
    1520                 1525                 1530             


Ser Lys  Lys Leu Ala Gly Ser  Glu Leu Phe Ala Lys  Val Lys Glu 
    1535                 1540                 1545             


Thr Cys  Gln Arg Leu Leu Glu  Lys Pro Lys Gly Ser  Phe Ile Leu 
    1550                 1555                 1560             


Leu 
    


<210>  876
<211>  7242
<212>  DNA
<213>  Homo Sapiens

<400>  876
tttcacctcg cggccgtagg ctaacgtgga agtcggacca gccggccggc ggaagaacct       60

agagcgcgct gcctggcgag tcaggcgcgc ggggcggcgt tggtggtctt cgcggcgcaa      120

ctcggccttt cctgggaggg agtgatgggg cgcaccgggg ccggggagcg ggcgccagtg      180

tagcccgcgc ggcgcctggc ccggagcgcg gcggctgcgg cggcggcggc ggcgggcgct      240

ggaggcctgt gagagccgca gcccggagcg cccggcttcc cacgccatgg cccccatggg      300

catccgcctt tccccactgg gggtggcagt gttttgcctg ctggggctcg gcgtgctcta      360

ccacctctac tcgggcttct tggccggccg cttcagcctc ttcggcctgg gcggcgagcc      420

tggcggcggc gcggcggggc ccgcggccgc ggccgatggg ggcaccgtgg acttgcgcga      480

gatgctggct gtgtcagtgc tggccgcagt ccgcggcggc gacgaggtga ggcgcgtccg      540

cgagagcaac gtcctccacg agaagtccaa ggggaagacg cgcgagggag ccgaggacaa      600

gatgaccagc ggcgacgtgc tgtccaaccg caagatgttc tacctgctca agaccgcctt      660

ccccagcgtc cagattaata ctgaggaaca cgtggatgca gctgatcagg aggttatctt      720

gtgggatcat aagattcctg aggatatcct aaaggaagta actactccta aagaggtacc      780

agcagaaagt gttactgtct ggattgaccc acttgatgct acacaggaat atacagagga      840

tcttcgaaag tacgtcacta ctatggtgtg tgtggctgta aatggtaaac ccatgctagg      900

agttatacat aagccatttt ccgaatatac agcttgggca atggtagatg gtggttcaaa      960

tgtgaaagcc cgctcttcct acaatgagaa gaccccaagg atcgttgtgt ctcgttccca     1020

ttcagggatg gtcaaacagg tcgctcttca gacttttgga aaccagacta caattatccc     1080

agctggtggt gctggttata aagttttagc acttttggat gtgcctgata agagtcaaga     1140

aaaagctgat ttatacatcc atgtgacata catcaaaaag tgggatatat gtgctggtaa     1200

tgccatctta aaagccctag gggggcatat gactaccctg agtggtgaag aaatcagtta     1260

cactggttca gacggcattg aagggggact ccttgctagc atcagaatga accaccaggc     1320

cctggtcaga aaactcccag atctagaaaa gacaggacat aaatgagcat aactgattac     1380

agggtacagt tcttcacagc tgaaatggtt agcctgagat gctggaagct tcaaaggatt     1440

ggtggagact atgcatggtt aaggccatcc cgaacttttt aaagtattta tgaagcatca     1500

gagacttatt ttccctgtaa tagaatgcaa aatcagggaa aatgggttgc tttgtgtctc     1560

aagtattgtc tttatttttg agactatttt catacagttg tcatacacaa ggcgcatata     1620

tatatttgtg aattaaaatc tgtagctgag tctacattgt tatgagtcac cattttcaca     1680

caacatcatg aatcttcact gttagtactt tcatatagaa ttcggttgaa ggaaagattg     1740

atttttgtgt agatgtttaa tataacttta caactatatc tcattgaaaa taaagtcatt     1800

ggggattttt acctctaatt tggatggaaa gcacaagaag ccacacattc attaatatgc     1860

aacaaatgtt gtatttatgt tactgaatat ttctatggat taaaatagaa aaagtttaat     1920

tgattttttc ttttaaattt taataacagg ttcaccagct ggtagaaaat agagacacat     1980

gatgatttgc attgtaataa tttctgtgtg tatgtgtgtg tgttgttttg tttttataaa     2040

gaaaagtgtg tttgtaccca tgagttcagc atttctgcca tcttgctatt ttcattttcc     2100

ctgtggaaga tgcatggttg catccttttc cttctgacca acacttagtc tttaactttg     2160

taaggttcgg tttaaggttt cagggttagc actatagttt tggttcattt tctcattaac     2220

gataaaatat gctgtaaggc actataagaa tataaatgat tctattacaa ttgaaagtta     2280

cttgacatta catgaattga actgcctttc attatcttca gacactttgt tttagtattt     2340

ttttttaatt tgctaggttt gtatatagaa gatcctttca ttatcaagaa tgagtatggt     2400

tgcttttgcc atggttgctt ttactattaa taaatgtatc tagcctaccc aaactctgta     2460

gtaacttttg agattctctt aatttcccct cagattaaaa tagagaaggt tgaaggtact     2520

ttttgatgaa atttttttct agtctggtta gaaaaaaaaa gttgtgacat attcattgtg     2580

ttaccgtaac tagaaccttg ctttgtgaac tgtctttcat tgggatgtat ggtttctctc     2640

aatgtgaaat ctggaaactt catgtaaact acccatgccg ttatttcatg tgactccagt     2700

gcccttgtat tccataacat gctgatgaga gggatttctc acggtttctt tctttgctaa     2760

attttttaac cataaagcag cttacccttt attttcccat cttggaagta aaattgacca     2820

aagaatgtac gttctagcct ggtggaatgt gcatacttta ggtttgtatg ttacattgtc     2880

caaagccctt tactttctta ttagtaaact gaatctaata tgacacaaat gttttcaccc     2940

aatctcttgc aactggtcaa attcgagaag gtgttgggcc ttagcagtag gccttttcag     3000

tgaaaattca ttcaaagttt tggtaggtgg aacacttgat atttaaatag gacttgaaaa     3060

ttttgaaaag agtatcagag acctcatttt tttcctttgc aataagctga agaaactttc     3120

tttttcagga gagatggcaa aggtatatgc tgttgccaga gtcctgtggt ataagcatct     3180

gtttttatta tagtatgtca aagttaggga aatgggactg gcaagtaaaa aatggaattt     3240

aatttcaatg ttttatggga actctgattt aatgggaagc aaactagttc atattagcag     3300

gaattatttt attttttcga gacagagttt cactctcgtt ggccaggctg gagtgcaatg     3360

gcgtgatctc ggctcaccgc aacctctgct tcccgggttc aagcgattct cctgcctcag     3420

cctcccaagt agctgggatt acaggcatac accaccacac ccagctaatt tttttgtatt     3480

tttgttagag acagggtttc tccatgttgg tcaggctggt ctcgaactcc cgacctcagg     3540

tgatccgccc acctcggcct cccaaagtga tgattttatt tttattttta attgtattaa     3600

tctgcatcta gataatgact ttgtgaaggg tgtgtgttgt gtgcaaaact taaggtattg     3660

gttgagagtt aaatacatta tttttataat atgttgggta tagtctagtt actaatgatt     3720

ttttttaagt acttttataa aaagttcatt tttaaaattg tttgttttta aaagccaata     3780

tacgttgcag aattaggaac agtatttata tttatttaca caagacattg tgccatagca     3840

tcctagtaaa acaccttcat gaatgagtaa tgttatctcc cagaattaca ttaaaattat     3900

ttctaaaaag tagcaaagtc attacctttt gcttttaatg acccacacct caccagctcc     3960

tggtcttttc ttcactgttg cccttatttt gaggcaattt ttcttaaaat atgactttta     4020

tgcaccacat ttagtagagg cagtgacatc agtgatctca gtacccatca gctgtccccc     4080

tcctctgccc ttcttcatct cttctacctt gtgaccattt cccttaccgg ttcatgttct     4140

cctttatctc tgcttttctt tcttagccag gatacttccc tcacaactct cactcccaaa     4200

ttcttttaga tatacatttt tctggatatt ggctgctgaa atctgaagct ctggtaaagt     4260

tcctagtatc agagatcaat cctggaggag gcctagttca ctattagatt acaaagactc     4320

ctcacaaagt aaaggaaaat caccttcaaa accacaaccc tttatgttgt caagtctaat     4380

atgagtgttt ttacgaagta tttctttcta cccattgttc aagaatgtaa atgtaaaaaa     4440

aaatacaaga gagttgggta gatatgcatg cttgaggaaa cttgctttta ctgttttcct     4500

acttgtatcc ccagttcagt tgaatttaca aggacctaca agatggtcat gtttgtcttg     4560

gtatgtgcta ccccaatttt agtgtttctt tctttatttt aaatcagtaa ttattcagtt     4620

gattgtttat actatataat gaagtaacaa aaacattttg gtttgtatgt tttaagtaac     4680

agttgtgcaa attcctcttg tttgttaggt gctccctttg aatattttgt gaactgtgtc     4740

agagggagag gggtggtggc taggaagagg gtcagaaaga agctagaggg aggtcaggag     4800

aagggtaaca gggaggatgc aaagcagaca tctaccctgg tcaccccagg atcaggatat     4860

ctgtccttgt ttcatgttga attcaaaaat tggatctcac ttaggctttg aaggtgacag     4920

ccatctctga tagctgagca taagtaaaga aaggtggagt gccgatgcag aaaggaaaat     4980

attcagcttt cctctcttag atcgcacttt gaagatggcc ttttggagac aatctgacag     5040

gttaaaacag gaactgttgg aattattcta gctgtaacta cctattggct atgtgttgat     5100

tgatcctaga aagaaaaaat aatttttcat tttagatctt gattgaattt aagatgtatt     5160

tatatgccta caaaaggtct gtcttgtaac tgttgtataa aataaaccta atctatggtt     5220

tcatttttaa tctaaaaaaa gttgtgcctt aacaataggg cattgtatgt taataaggga     5280

aaacaacctt tttagtagat gggggaaaat aggaactttt tgccattaaa acttaagttc     5340

ttttgatgtt tttaatatta tagttggggg agattcatta aaattaaatt gaaataaaat     5400

tatttttgca taacctagca tttacaacta aagtatgttt tttataagaa ctggcatctt     5460

gatgtatata ggtctgaaat aatatttcat cttttgattt ttaattttaa taatattaga     5520

ccaggataga tcacagtttt acaaatctta gttttaaata aattatttca gtgtgctgtt     5580

agtcctctac agtcattttg gtttaaaaag tgactattta tttatggtag catatcaata     5640

atttattaat gttaaaaaat actgtgtatg acattacaaa ccagaacagt tcctggggga     5700

gaggattcta attgattggc agttctgaga gggcaagaag aatggaactt tatacttcaa     5760

aaggaggttt tggttttacc aggtactgct tatgtaaatc gtttattttt atttcatcaa     5820

agcctggcaa gtatatgcat tccaatttac cattggcaaa gctttattta tttttaaggt     5880

tggatgttga attaattttg tgggaaaatg agatttgtaa gtagttttct ttctagataa     5940

gataacataa accaaacttt cagaagttaa ggatgatgaa taatattgaa atgacttgtt     6000

atatattgta agggttccct taagtatcat aattaacaat ttgtggaaat tgaaaaagca     6060

taaactgtgt tatttgatta gtaatatgtt cccttaaaat tcattttgag gtgtatgtta     6120

tacacacagt aaatttttgt tcaggaatga cttgctcatt ctgtgttttt aaaaatagga     6180

aataaggcat agtgagtcat cattacatca attaaccaaa aaatatttca tcccctccgt     6240

cactgaaatt atctacttca gccacctttc ttattctcgt gttaggaggg cacgtttatg     6300

gactttttaa tttccatgtg ccatattgtc cactaccggc agtagccaaa gctagctgtt     6360

tcagtcccac agaagagaca gtgctctgcc atgatgacag ggcactgcta gggctggttt     6420

ttcttgtttt tcccttttgg cagtgtggac ttcaggaact agatgtatat gcacaaggga     6480

ttgagtttac actaaaacta ggaaatggag ttttcaatct atgttcttgc ctcttcatac     6540

ttttatttat tttttgtcat cctgccttat actgggctaa caatgagata aaataaaaat     6600

acctttgaat actcttttcc ctttcatgca tttaaagcca tggaggaact agaccattag     6660

ctgttgccgt cacatgctta gacaccagtt tacttagcgt gttatgacct tcctcaccca     6720

tactaccaaa tttaaatggg tcccgacttc accctctgga aggaagtaaa ctcttctctc     6780

cccatggttt cagagcagtt tttacctgca agcaccatct ctgtatgtgc tcttactaga     6840

ttatacagtt cttgagaggg attgcatctt agtgtttttg tatttccacc tcacccccag     6900

cacatagccc agtctcttgc acaaattaag tacttaatgt gtgttgagct aaattgaata     6960

aaggattatt agcattagca tattttgtgc cttggttgta taagctggtt gtttgttttg     7020

ttacctttgc aaatatttat gattatcacc cccccacata ctaaattgtt tttaaaagtt     7080

ttgcctttcc ttcagatact accccaggca atttgctgta gataatgtga ttgcttccaa     7140

tgacataatt atcccaaact ctctgccccg gatatacttt gccaaacgaa atttgaattc     7200

tctgaataaa ttggtcatgt ctaaaagaga aaaaaaaaaa aa                        7242


<210>  877
<211>  359
<212>  PRT
<213>  Homo Sapiens

<400>  877

Met Ala Pro Met Gly Ile Arg Leu Ser Pro Leu Gly Val Ala Val Phe 
1               5                   10                  15      


Cys Leu Leu Gly Leu Gly Val Leu Tyr His Leu Tyr Ser Gly Phe Leu 
            20                  25                  30          


Ala Gly Arg Phe Ser Leu Phe Gly Leu Gly Gly Glu Pro Gly Gly Gly 
        35                  40                  45              


Ala Ala Gly Pro Ala Ala Ala Ala Asp Gly Gly Thr Val Asp Leu Arg 
    50                  55                  60                  


Glu Met Leu Ala Val Ser Val Leu Ala Ala Val Arg Gly Gly Asp Glu 
65                  70                  75                  80  


Val Arg Arg Val Arg Glu Ser Asn Val Leu His Glu Lys Ser Lys Gly 
                85                  90                  95      


Lys Thr Arg Glu Gly Ala Glu Asp Lys Met Thr Ser Gly Asp Val Leu 
            100                 105                 110         


Ser Asn Arg Lys Met Phe Tyr Leu Leu Lys Thr Ala Phe Pro Ser Val 
        115                 120                 125             


Gln Ile Asn Thr Glu Glu His Val Asp Ala Ala Asp Gln Glu Val Ile 
    130                 135                 140                 


Leu Trp Asp His Lys Ile Pro Glu Asp Ile Leu Lys Glu Val Thr Thr 
145                 150                 155                 160 


Pro Lys Glu Val Pro Ala Glu Ser Val Thr Val Trp Ile Asp Pro Leu 
                165                 170                 175     


Asp Ala Thr Gln Glu Tyr Thr Glu Asp Leu Arg Lys Tyr Val Thr Thr 
            180                 185                 190         


Met Val Cys Val Ala Val Asn Gly Lys Pro Met Leu Gly Val Ile His 
        195                 200                 205             


Lys Pro Phe Ser Glu Tyr Thr Ala Trp Ala Met Val Asp Gly Gly Ser 
    210                 215                 220                 


Asn Val Lys Ala Arg Ser Ser Tyr Asn Glu Lys Thr Pro Arg Ile Val 
225                 230                 235                 240 


Val Ser Arg Ser His Ser Gly Met Val Lys Gln Val Ala Leu Gln Thr 
                245                 250                 255     


Phe Gly Asn Gln Thr Thr Ile Ile Pro Ala Gly Gly Ala Gly Tyr Lys 
            260                 265                 270         


Val Leu Ala Leu Leu Asp Val Pro Asp Lys Ser Gln Glu Lys Ala Asp 
        275                 280                 285             


Leu Tyr Ile His Val Thr Tyr Ile Lys Lys Trp Asp Ile Cys Ala Gly 
    290                 295                 300                 


Asn Ala Ile Leu Lys Ala Leu Gly Gly His Met Thr Thr Leu Ser Gly 
305                 310                 315                 320 


Glu Glu Ile Ser Tyr Thr Gly Ser Asp Gly Ile Glu Gly Gly Leu Leu 
                325                 330                 335     


Ala Ser Ile Arg Met Asn His Gln Ala Leu Val Arg Lys Leu Pro Asp 
            340                 345                 350         


Leu Glu Lys Thr Gly His Lys 
        355                 


<210>  878
<211>  460
<212>  PRT
<213>  Homo Sapiens

<400>  878

Met Ala Pro Arg Ser Arg Arg Arg Arg His Lys Lys Pro Pro Ser Ser 
1               5                   10                  15      


Val Ala Pro Ile Ile Met Ala Pro Thr Thr Ile Val Thr Pro Val Pro 
            20                  25                  30          


Leu Thr Pro Ser Lys Pro Gly Pro Ser Ile Asp Thr Leu Gly Phe Phe 
        35                  40                  45              


Ser Leu Asp Asp Asn Val Pro Gly Leu Ser Gln Leu Ile Leu Gln Lys 
    50                  55                  60                  


Leu Asn Met Lys Ser Tyr Glu Glu Tyr Lys Leu Val Val Asp Gly Gly 
65                  70                  75                  80  


Thr Pro Val Ser Gly Phe Gly Phe Arg Cys Pro Gln Glu Met Phe Gln 
                85                  90                  95      


Arg Met Glu Asp Thr Phe Arg Phe Cys Ala His Cys Arg Ala Leu Pro 
            100                 105                 110         


Ser Gly Leu Ser Asp Ser Lys Val Leu Arg His Cys Lys Arg Cys Arg 
        115                 120                 125             


Asn Val Tyr Tyr Cys Gly Pro Glu Cys Gln Lys Ser Asp Trp Pro Ala 
    130                 135                 140                 


His Arg Arg Val Cys Gln Glu Leu Arg Leu Val Ala Val Asp Arg Leu 
145                 150                 155                 160 


Met Glu Trp Leu Leu Val Thr Gly Asp Phe Val Leu Pro Ser Gly Pro 
                165                 170                 175     


Trp Pro Trp Pro Pro Glu Ala Val Gln Asp Trp Asp Ser Trp Phe Ser 
            180                 185                 190         


Met Lys Gly Leu His Leu Asp Ala Thr Leu Asp Ala Val Leu Val Ser 
        195                 200                 205             


His Ala Val Thr Thr Leu Trp Ala Ser Val Gly Arg Pro Arg Pro Asp 
    210                 215                 220                 


Pro Asp Val Leu Gln Gly Ser Leu Lys Arg Leu Leu Thr Asp Val Leu 
225                 230                 235                 240 


Ser Arg Pro Leu Thr Leu Gly Leu Gly Leu Arg Ala Leu Gly Ile Asp 
                245                 250                 255     


Val Arg Arg Thr Gly Gly Ser Thr Val His Val Val Gly Ala Ser His 
            260                 265                 270         


Val Glu Thr Phe Leu Thr Arg Pro Gly Asp Tyr Asp Glu Leu Gly Tyr 
        275                 280                 285             


Met Phe Pro Gly His Leu Gly Leu Arg Val Val Met Val Gly Val Asp 
    290                 295                 300                 


Val Ala Thr Gly Phe Ser Gln Ser Thr Ser Thr Ser Pro Leu Glu Pro 
305                 310                 315                 320 


Gly Thr Ile Gln Leu Ser Ala His Arg Gly Leu Tyr His Asp Phe Trp 
                325                 330                 335     


Glu Glu Gln Val Glu Thr Gly Gln Thr His His Pro Asp Leu Val Ala 
            340                 345                 350         


Ala Phe His Pro Gly Phe His Ser Ser Pro Asp Leu Met Glu Ala Trp 
        355                 360                 365             


Leu Pro Thr Leu Leu Leu Leu Arg Asp Tyr Lys Ile Pro Thr Leu Ile 
    370                 375                 380                 


Thr Val Tyr Ser His Gln Glu Leu Val Ser Ser Leu Gln Ile Leu Val 
385                 390                 395                 400 


Glu Leu Asp Thr His Ile Thr Ala Phe Gly Ser Asn Pro Phe Met Ser 
                405                 410                 415     


Leu Lys Pro Glu Gln Val Tyr Ser Ser Pro Asn Lys Gln Pro Val Tyr 
            420                 425                 430         


Cys Ser Ala Tyr Tyr Ile Met Phe Leu Gly Ser Ser Cys Gln Leu Asp 
        435                 440                 445             


Asn Arg Gln Leu Glu Glu Lys Val Asp Gly Gly Ile 
    450                 455                 460 


<210>  879
<211>  1945
<212>  DNA
<213>  Homo Sapiens

<400>  879
agcggtccgc actcggggag gcgggagggt gacggcggtg ctgcgaggtc ggcgcgcagc       60

tccgccgcgg gtcgctcggg cgctgtccag gcggagccgg ccccgcccgg gctgcagcca      120

tgatcaagcg tttcctggag gacaccacgg atgatggaga actgagcaag ttcgtgaagg      180

atttctcagg aaatgcgagc tgccacccac cagaggctaa gacctgggca tccaggcccc      240

aagtcccgga gccaaggccc caggccccgg acctctatga tgatgacctg gagttcagac      300

ccccctcgcg gccccagtcc tctgacaacc agcagtactt ctgtgcccca gcccctctca      360

gcccatctgc caggccccgc agcccatggg gcaagcttga tccctatgat tcctctgagg      420

atgacaagga gtatgtgggc tttgcaaccc tccccaacca agtccaccga aagtccgtga      480

agaaaggctt tgactttacc ctcatggtgg caggagagtc tggcctgggc aaatccacac      540

ttgtcaatag cctcttcctc actgatctgt accgggaccg gaaacttctt ggtgctgaag      600

agaggatcat gcaaactgtg gagatcacta agcatgcagt ggacatagaa gagaagggtg      660

tgaggctgcg gctcaccatt gtggacacac caggttttgg ggatgcagtc aacaacacag      720

agtgctggaa gcctgtggca gaatacattg atcagcagtt tgagcagtat ttccgagacg      780

agagtggcct gaaccgaaag aacatccaag acaacagggt gcactgctgc ctgtacttca      840

tctcaccctt cggccatggg tatggtccaa gcctgaggct cctggcacca ccgggtgctg      900

tcaagggaac aggccaagag caccaggggc agggctgcca ctagcaggtg gtcacaggtt      960

cctgttcccc aggctccggc cattggatgt tgaattcatg aaggccctgc atcagcgggt     1020

caacatcgtg cctatcctgg ctaaggcaga cacactgaca cctcccgaag tggaccacaa     1080

gaaacgcaaa atccgggagg agattgagca ttttggaatc aagatctatc aattcccaga     1140

ctgtgactct gatgaggatg aggacttcaa attgcaggac caagccctaa aggaaagcat     1200

cccatttgca gtaattggca gcaacactgt agtagaggcc agagggcggc gagttcgggg     1260

tcgactctac ccctggggca tcgtggaagt ggaaaaccca gggcactgcg actttgtgaa     1320

gctgaggaca atgctggtac gtacccacat gcaggacctg aaggatgtga cacgggagac     1380

acattatgag aactaccggg cacagtgcat ccagagcatg acccgcctgg tggtgaagga     1440

acggaatcgc aagtatgacc agaagccagg acaaagctgg cagggggaga tcccaagcct     1500

agccttgggt gagaccaagc cctacttttg ttcttctata ggccctgggc tcaatctaag     1560

cgggtgctgg ggtcctcctc gccttatcaa cccttttctc cctttagcaa actgactcgg     1620

gaaagtggta ccgacttccc catccctgct gtcccaccag ggacagatcc agaaactgag     1680

aagcttatcc gagagaaaga tgaggagctg cggcggatgc aggagatgct acacaaaata     1740

caaaaacaga tgaaggagaa ctattaactg gctttcagcc ctggatattt aaatctcctc     1800

ctcttcttcc tgtccatgcc ggcccctccc agcaccagct ctgctcaggc cccttcagct     1860

actgccactt cgccttacat ccctgctgac tgcccagaga ctcagaggaa ataaagttta     1920

ataaatctgt aggtggcttc tggaa                                           1945


<210>  880
<211>  274
<212>  PRT
<213>  Homo Sapiens

<400>  880

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser 
    130                 135                 140                 


Leu Phe Leu Thr Asp Leu Tyr Arg Asp Arg Lys Leu Leu Gly Ala Glu 
145                 150                 155                 160 


Glu Arg Ile Met Gln Thr Val Glu Ile Thr Lys His Ala Val Asp Ile 
                165                 170                 175     


Glu Glu Lys Gly Val Arg Leu Arg Leu Thr Ile Val Asp Thr Pro Gly 
            180                 185                 190         


Phe Gly Asp Ala Val Asn Asn Thr Glu Cys Trp Lys Pro Val Ala Glu 
        195                 200                 205             


Tyr Ile Asp Gln Gln Phe Glu Gln Tyr Phe Arg Asp Glu Ser Gly Leu 
    210                 215                 220                 


Asn Arg Lys Asn Ile Gln Asp Asn Arg Val His Cys Cys Leu Tyr Phe 
225                 230                 235                 240 


Ile Ser Pro Phe Gly His Gly Tyr Gly Pro Ser Leu Arg Leu Leu Ala 
                245                 250                 255     


Pro Pro Gly Ala Val Lys Gly Thr Gly Gln Glu His Gln Gly Gln Gly 
            260                 265                 270         


Cys His 
        


<210>  881
<211>  2873
<212>  DNA
<213>  Homo Sapiens

<400>  881
cggcacgccc gggaggcttt ctctggctgg taaccgctac tcccggacac cagaccaccg       60

ccttccgtac acaggggccc gcatcccacc ctcccggacc taagagcctg ggtcccctgt      120

ttccggaggt ccgcttcccg gcccccagat tctggcatcc cagccctcag tgtccaagac      180

ccaggcagcc cgggtccccg cctcccggat ccaggcgtcc gggatctgcg ccaccagaac      240

ctagcctcct gcagacctcc gccatctggg ggcactcaac ctcctggagc caagggcccc      300

acgtcccacc cagagaaact ctcgtattcc cagctcctag ggccaaggaa cccgggcgct      360

ccgaactccc agctttcgga catctggcac acggggcaga gcagagaagc ctcagcgccc      420

agcctgggga atttaaacac tccagcttcc aagagccaag gaacttcagt gctgtgaact      480

cacaactcta aggagccctc caaagttcca gtctccaggt gctgttactc aactcagtcc      540

taggaacgtc gggtcctggg aaggagccca agcgctccca gccagcttcc aggcgctaag      600

aaaccccggt gcttcccatc atggtggccg atcctcctcg agactccaag gggctcgcag      660

cggcggagcc caccgccaac gggggcctgg cgctggcctc catcgaggac caaggcgcgg      720

cagcaggcgg ctactgcggt tcccgggacc aggtgcgccg ctgccttcga gccaacctgc      780

ttgtgctgct gacagtggtg gccgtggtgg ccggcgtggc gctgggactg ggggtgtcgg      840

gggccggggg tgcgctggcg ttgggcccgg agcgcttgag cgccttcgtc ttcccgggcg      900

agctgctgct gcgtctgctg cggatgatca tcttgccgct ggtggtgtgc agcttgatcg      960

gcggcgccgc cagcctggac cccggcgcgc tcggccgtct gggcgcctgg gcgctgctct     1020

ttttcctggt caccacgctg ctggcgtcgg cgctcggagt gggcttggcg ctggctctgc     1080

agccgggcgc cgcctccgcc gccatcaacg cctccgtggg agccgcgggc agtgccgaaa     1140

atgcccccag caaggaggtg ctcgattcgt tcctggatct tgcgagaaat atcttccctt     1200

ccaacctggt gtcagcagcc tttcgctcat actctaccac ctatgaagag aggaatatca     1260

ccggaaccag ggtgaaggtg cccgtggggc aggaggtgga ggggatgaac atcctgggct     1320

tggtagtgtt tgccatcgtc tttggtgtgg cgctgcggaa gctggggcct gaaggggagc     1380

tgcttatccg cttcttcaac tccttcaatg aggccaccat ggttctggtc tcctggatca     1440

tgtggtacgc ccctgtgggc atcatgttcc tggtggctgg caagatcgtg gagatggagg     1500

atgtgggttt actctttgcc cgccttggca agtacattct gtgctgcctg ctgggtcacg     1560

ccatccatgg gctcctggta ctgcccctca tctacttcct cttcacccgc aaaaacccct     1620

accgcttcct gtggggcatc gtgacgccgc tggccactgc ctttgggacc tcttccagtt     1680

ccgccacgct gccgctgatg atgaagtgcg tggaggagaa taatggcgtg gccaagcaca     1740

tcagccgttt catcctgccc atcggcgcca ccgtcaacat ggacggtgcc gcgctcttcc     1800

agtgcgtggc cgcagtgttc attgcacagc tcagccagca gtccttggac ttcgtaaaga     1860

tcatcaccat cctggtcacg gccacagcgt ccagcgtggg ggcagcgggc atccctgctg     1920

gaggtgtcct cactctggcc atcatcctcg aagcagtcaa cctcccggtc gaccatatct     1980

ccttgatcct ggctgtggac tggctagtcg accggtcctg taccgtcctc aatgtagaag     2040

gtgacgctct gggggcagga ctcctccaaa attacgtgga ccgtacggag tcgagaagca     2100

cagagcctga gttgatacaa gtgaagagtg agctgcccct ggatccgctg ccagtcccca     2160

ctgaggaagg aaaccccctc ctcaaacact atcgggggcc cgcaggggat gccacggtcg     2220

cctctgagaa ggaatcagtc atgtaaaccc cgggagggac cttccctgcc ctgctggggg     2280

tgctctttgg acactggatt atgaggaatg gataaatgga tgagctaggg ctctgggggt     2340

ctgcctgcac actctgggga gccaggggcc ccagcaccct ccaggacagg agatctggga     2400

tgcctggctg ctggagtaca tgtgttcaca agggttactc ctcaaaaccc ccagttctca     2460

ctcatgtccc caactcaagg ctagaaaaca gcaagatgga gaaataatgt tctgctgcgt     2520

ccccaccgtg acctgcctgg cctcccctgt ctcagggagc aggtcacagg tcaccatggg     2580

gaattctagc ccccactggg gggatgttac aacaccatgc tggttatttt ggcggctgta     2640

gttgtggggg gatgtgtgtg tgcacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     2700

tgttctgtga cctcctgtcc ccatggtacg tcccaccctg tccccagatc ccctattccc     2760

tccacaataa cagaaacact cccagggact ctggggagag gctgaggaca aatacctgct     2820

gtcactccag aggacatttt ttttagcaat aaaattgagt gtcaactatt taa            2873


<210>  882
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  882

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  883
<211>  5565
<212>  DNA
<213>  Homo Sapiens

<400>  883
ggcgcggcgc tcgcggctgc tgcctgggag ggaggccggg caggcggctg agcggcgcgg       60

ctctcaacgt gacggggaag tggttcgggc ggccgcggct tactacccca gggcgaacgg      120

acggacgacg gaggcgggag ccggtagccg agccgggcga cctagagaac gagcgggtca      180

ggctcagcgt cggccactct gtcggtccgc tgaatgaagt gcccgcccct ctaagcccgg      240

agcccggcgc tttccccgca agatggacgg tttcgccggc agtctcgatg atagtatttc      300

tgctgcaagt acttctgatg ttcaagatcg cctgtcagct cttgagtcac gagttcagca      360

acaagaagat gaaatcactg tgctaaaggc ggctttggct gatgttttga ggcgtcttgc      420

aatctctgaa gatcatgtgg cctcagtgaa aaaatcagtc tcaagtaaag gccaaccaag      480

ccctcgagca gttattccca tgtcctgtat aaccaatgga agtggtgcaa acagaaaacc      540

aagtcatacc agtgctgtct caattgcagg aaaagaaact ctttcatctg ctgctaaaag      600

tggtacagaa aaaaagaaag aaaaaccaca aggacagaga gaaaaaaaag aggaatctca      660

ttctaatgat caaagtccac aaattcgagc atcaccttct ccccagccct cttcacaacc      720

tctccaaata cacagacaaa ctccagaaag caagaatgct actcccacca aaagcataaa      780

acgaccatca ccagctgaaa agtcacataa ttcttgggaa aattcagatg atagccgtaa      840

taaattgtcg aaaatacctt caacacccaa attaatacca aaagttacca aaactgcaga      900

caagcataaa gatgtcatca tcaaccaaga aggagaatat attaaaatgt ttatgcgcgg      960

tcggccaatt accatgttca ttccttccga tgttgacaac tatgatgaca tcagaacgga     1020

actgcctcct gagaagctca aactggagtg ggcatatggt tatcgaggaa aggactgtag     1080

agctaatgtt taccttcttc cgaccgggga aatagtttat ttcattgcat cagtagtagt     1140

actatttaat tatgaggaga gaactcagcg acactacctg ggccatacag actgtgtgaa     1200

atgccttgct atacatcctg acaaaattag gattgcaact ggacagatag ctggcgtgga     1260

taaagatgga aggcctctac aaccccacgt cagagtgtgg gattctgtta ctctatccac     1320

actgcagatt attggacttg gcacttttga gcgtggagta ggatgcctgg atttttcaaa     1380

agcagattca ggtgttcatt tatgtgttat tgatgactcc aatgagcata tgcttactgt     1440

atgggactgg cagaagaaag caaaaggagc agaaataaag acaacaaatg aagttgtttt     1500

ggctgtggag tttcacccaa cagatgcaaa taccataatt acatgcggta aatctcatat     1560

tttcttctgg acctggagcg gcaattcact aacaagaaaa cagggaattt ttgggaaata     1620

tgaaaagcca aaatttgtgc agtgtttagc attcttgggg aatggagatg ttcttactgg     1680

agactcaggt ggagtcatgc ttatatggag caaaactact gtagagccca cacctgggaa     1740

aggacctaaa ggtgtatatc aaatcagcaa acaaatcaaa gctcatgatg gcagtgtgtt     1800

cacactttgt cagatgagaa atgggatgtt attaactgga ggagggaaag acagaaaaat     1860

aattctgtgg gatcatgatc tgaatcctga aagagaaata gaggttcctg atcagtatgg     1920

cacaatcaga gctgtagcag aaggaaaggc agatcaattt ttagtaggca catcacgaaa     1980

ctttatttta cgaggaacat ttaatgatgg cttccaaata gaagtacagg gtcatacaga     2040

tgagctttgg ggtcttgcca cacatccctt caaagatttg ctcttgacat gtgctcagga     2100

caggcaggtg tgcctgtgga actcaatgga acacaggctg gaatggacca ggctggtaga     2160

tgaaccagga cactgtgcag attttcatcc aagtggcaca gtggtggcca taggaacgca     2220

ctcaggcagg tggtttgttc tggatgcaga aaccagagat ctagtttcta tccacacaga     2280

cgggaatgaa cagctctctg tgatgcgcta ctcaatagat ggtaccttcc tggctgtagg     2340

atctcatgac aactttattt acctctatgt agtctctgaa aatggaagaa aatatagcag     2400

atatggaagg tgcactggac attccagcta catcacacac cttgactggt ccccagacaa     2460

caagtatata atgtctaact cgggagacta tgaaatattg tactgggaca ttccaaatgg     2520

ctgcaaacta atcaggaatc gatcggattg taaggacatt gattggacga catatacctg     2580

tgtgctagga tttcaagtat ttggtgtctg gccagaagga tctgatggga cagatatcaa     2640

tgcactggtg cgatcccaca atagaaaggt gatagctgtt gccgatgact tttgtaaagt     2700

ccatctgttt cagtatccct gctccaaagc aaaggctccc agtcacaagt acagtgccca     2760

cagcagccat gtcaccaatg tcagttttac tcacaatgac agtcacctga tatcaactgg     2820

tggaaaagac atgagcatca ttcagtggaa acttgtggaa aagttatctt tgcctcagaa     2880

tgagactgta gcggatacta ctctaaccaa agcccccgtc tcttccactg aaagtgtcat     2940

ccaatctaat actcccacac cgcctccttc tcagccctta aatgagacag ctgaagagga     3000

aagtagaata agcagttctc ccacacttct ggagaacagc ctggaacaaa ctgtggagcc     3060

aagtgaagac cacagcgagg aggagagtga agagggcagc ggagaccttg gtgagcctct     3120

ttatgaagag ccatgcaacg agataagcaa ggagcaggcc aaagccaccc ttctggagga     3180

ccagcaagac ccttcgccct cgtcctaaca ccctggcttc agtgcaactc ttttccttca     3240

gctgcatgtg attttgtgat aaagttcagg taacaggatg ggcagtgatg gagaatcact     3300

gttgattgag attttggttt ccatgtgatt tgttttcttc aatagtctta ttttcagtct     3360

ctcaaataca gccaacttaa agttttagtt tggtgtttat tgaaaattaa ccaaacttaa     3420

tactaggaga agactgaatc attaatgatg tctcacaaat tactgtgtac ctaagtggtg     3480

tgatgtaaat actggaaaca aaaacagcag ttgcattgat tttgaaaaca aacccccttg     3540

ttatctgaac atgttttctt caggaacaac cagaggtatc acaaacactg ttactcatct     3600

actggctcag actgtactac tttttttttt ttttttcctg aaaaagaaac cagaaaaaaa     3660

tgtactctta ctgagatacc ctctcacccc aaatgtgtaa tggaaaattt ttaattaaga     3720

aaaacttcag ttttgccaag tgcaatggtg ttgccttctt taaaaaatgc cgttttctta     3780

cactaccagt ggatgtccag acatgctctt agtctactag agaggtgctg ccttttctaa     3840

gtcataatga ggaacagtcc cttaatttct tgtgtgcaac tctgttttat cctagaacta     3900

agagagcatt ggtttgttaa agagctttca atgtatatta aaaccttcaa tactcagaaa     3960

tgatggattc ctccaaggag tcctttacta gcctaaacat tctcaaatgt ttgagattca     4020

agtgaatgga aggaaaacca catgccttta aaactaaact gtaataatta cctggctaat     4080

ttcagctaag ccttcatcat aatttgttcc ctcagtaata ggagaaatat aaatacagta     4140

agtttagatt attgaattgg tgcttgaaat ttattggttt tgttgtaatt ttatacagat     4200

tatatgaggg ataagatact catcaaattg caaattcttt tttttacaga agtgtgggta     4260

acagtcacag cagttttttt taccaacagc atacttaaca gacttgctgt gtagcagttt     4320

ttttctggtg gagttgctgt aagtcttgta agtctaatgt ggctatccta ctcttttggg     4380

caatgcatgt attatgcatt ggaaaggtat tttttttaag ttctgttggc tagctatggt     4440

tttcagtaca tttcctactt taagagtaat tactgacaaa tatgtatttc ctatatgttt     4500

atactttgat tataaaaaag tattttgttt tgatttttta acttgctgca ttgttttgat     4560

actttctatt tttttggtca aatcatgttt agaaactttg gatgagttaa gaagtcttaa     4620

gtatgcaggc gtttacgtga ttgtgccatt ccaaagtgca tcagaactgt cattcccttc     4680

taatatcttc tcaggagtaa tacaaatcag gtatttcatc atcatttggt aatatgaaaa     4740

ctccagtgaa ctcccaagga catttacaac atttatattc acacgctgta tggaagggtg     4800

tgggtgtgtg tgaaggggcg agtggagaca ctgtgtgtat ctctagataa gaagatatgc     4860

accacgttga aaatactcag tgtagatctc tatgtgtata ggtatctgta tatctttcct     4920

tttgtttaca actgttaaaa aacctcaaaa tagttctctt caaaagaaga gagattccaa     4980

gcaacccatc tttcttcagt atgtatgttc tgtacatact tatcggagcg cgccagtaag     5040

tatcaggcat atatatctgt ctgttagcaa tgattattac atcatcagat cagcatgtgc     5100

tatactccct gcaagaaata tactgacatg aacaggcagt tcttggagaa gaaagagcat     5160

ttctttaagt acctggggaa tacagctctc agtgatcagc agggagttta tttgaggaca     5220

tcagtcacct ttggggttgc catgtacaat gagatttata atcatgatac tcttcggtgg     5280

tagtttcaaa agacactact aatacgcagg aagcgttcca gctatttaat gctggcaact     5340

actgtttaat ggtcagttaa atctgtgata atggttggaa gtgggtgggg ttatgaaatt     5400

gtagatgttt ttagaaaaac ttgtgaatga aaatgaatcc aagtgtttca tgtgaagatg     5460

ttgagccatt gctatcatgc attcctgtct catggcagaa aattttgaag attaaaaaat     5520

aaaataatca aaatgtttcc tctttctaaa aaaaaaaaaa aaaaa                     5565


<210>  884
<211>  981
<212>  PRT
<213>  Homo Sapiens

<400>  884

Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Gly Thr Glu Lys Lys Lys Glu Lys Pro Gln Gly Gln Arg Glu Lys 
        115                 120                 125             


Lys Glu Glu Ser His Ser Asn Asp Gln Ser Pro Gln Ile Arg Ala Ser 
    130                 135                 140                 


Pro Ser Pro Gln Pro Ser Ser Gln Pro Leu Gln Ile His Arg Gln Thr 
145                 150                 155                 160 


Pro Glu Ser Lys Asn Ala Thr Pro Thr Lys Ser Ile Lys Arg Pro Ser 
                165                 170                 175     


Pro Ala Glu Lys Ser His Asn Ser Trp Glu Asn Ser Asp Asp Ser Arg 
            180                 185                 190         


Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro Lys Leu Ile Pro Lys Val 
        195                 200                 205             


Thr Lys Thr Ala Asp Lys His Lys Asp Val Ile Ile Asn Gln Glu Gly 
    210                 215                 220                 


Glu Tyr Ile Lys Met Phe Met Arg Gly Arg Pro Ile Thr Met Phe Ile 
225                 230                 235                 240 


Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile Arg Thr Glu Leu Pro Pro 
                245                 250                 255     


Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly Tyr Arg Gly Lys Asp Cys 
            260                 265                 270         


Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Ile 
        275                 280                 285             


Ala Ser Val Val Val Leu Phe Asn Tyr Glu Glu Arg Thr Gln Arg His 
    290                 295                 300                 


Tyr Leu Gly His Thr Asp Cys Val Lys Cys Leu Ala Ile His Pro Asp 
305                 310                 315                 320 


Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala Gly Val Asp Lys Asp Gly 
                325                 330                 335     


Arg Pro Leu Gln Pro His Val Arg Val Trp Asp Ser Val Thr Leu Ser 
            340                 345                 350         


Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe Glu Arg Gly Val Gly Cys 
        355                 360                 365             


Leu Asp Phe Ser Lys Ala Asp Ser Gly Val His Leu Cys Val Ile Asp 
    370                 375                 380                 


Asp Ser Asn Glu His Met Leu Thr Val Trp Asp Trp Gln Lys Lys Ala 
385                 390                 395                 400 


Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu Val Val Leu Ala Val Glu 
                405                 410                 415     


Phe His Pro Thr Asp Ala Asn Thr Ile Ile Thr Cys Gly Lys Ser His 
            420                 425                 430         


Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser Leu Thr Arg Lys Gln Gly 
        435                 440                 445             


Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe Val Gln Cys Leu Ala Phe 
    450                 455                 460                 


Leu Gly Asn Gly Asp Val Leu Thr Gly Asp Ser Gly Gly Val Met Leu 
465                 470                 475                 480 


Ile Trp Ser Lys Thr Thr Val Glu Pro Thr Pro Gly Lys Gly Pro Lys 
                485                 490                 495     


Gly Val Tyr Gln Ile Ser Lys Gln Ile Lys Ala His Asp Gly Ser Val 
            500                 505                 510         


Phe Thr Leu Cys Gln Met Arg Asn Gly Met Leu Leu Thr Gly Gly Gly 
        515                 520                 525             


Lys Asp Arg Lys Ile Ile Leu Trp Asp His Asp Leu Asn Pro Glu Arg 
    530                 535                 540                 


Glu Ile Glu Val Pro Asp Gln Tyr Gly Thr Ile Arg Ala Val Ala Glu 
545                 550                 555                 560 


Gly Lys Ala Asp Gln Phe Leu Val Gly Thr Ser Arg Asn Phe Ile Leu 
                565                 570                 575     


Arg Gly Thr Phe Asn Asp Gly Phe Gln Ile Glu Val Gln Gly His Thr 
            580                 585                 590         


Asp Glu Leu Trp Gly Leu Ala Thr His Pro Phe Lys Asp Leu Leu Leu 
        595                 600                 605             


Thr Cys Ala Gln Asp Arg Gln Val Cys Leu Trp Asn Ser Met Glu His 
    610                 615                 620                 


Arg Leu Glu Trp Thr Arg Leu Val Asp Glu Pro Gly His Cys Ala Asp 
625                 630                 635                 640 


Phe His Pro Ser Gly Thr Val Val Ala Ile Gly Thr His Ser Gly Arg 
                645                 650                 655     


Trp Phe Val Leu Asp Ala Glu Thr Arg Asp Leu Val Ser Ile His Thr 
            660                 665                 670         


Asp Gly Asn Glu Gln Leu Ser Val Met Arg Tyr Ser Ile Asp Gly Thr 
        675                 680                 685             


Phe Leu Ala Val Gly Ser His Asp Asn Phe Ile Tyr Leu Tyr Val Val 
    690                 695                 700                 


Ser Glu Asn Gly Arg Lys Tyr Ser Arg Tyr Gly Arg Cys Thr Gly His 
705                 710                 715                 720 


Ser Ser Tyr Ile Thr His Leu Asp Trp Ser Pro Asp Asn Lys Tyr Ile 
                725                 730                 735     


Met Ser Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Trp Asp Ile Pro Asn 
            740                 745                 750         


Gly Cys Lys Leu Ile Arg Asn Arg Ser Asp Cys Lys Asp Ile Asp Trp 
        755                 760                 765             


Thr Thr Tyr Thr Cys Val Leu Gly Phe Gln Val Phe Gly Val Trp Pro 
    770                 775                 780                 


Glu Gly Ser Asp Gly Thr Asp Ile Asn Ala Leu Val Arg Ser His Asn 
785                 790                 795                 800 


Arg Lys Val Ile Ala Val Ala Asp Asp Phe Cys Lys Val His Leu Phe 
                805                 810                 815     


Gln Tyr Pro Cys Ser Lys Ala Lys Ala Pro Ser His Lys Tyr Ser Ala 
            820                 825                 830         


His Ser Ser His Val Thr Asn Val Ser Phe Thr His Asn Asp Ser His 
        835                 840                 845             


Leu Ile Ser Thr Gly Gly Lys Asp Met Ser Ile Ile Gln Trp Lys Leu 
    850                 855                 860                 


Val Glu Lys Leu Ser Leu Pro Gln Asn Glu Thr Val Ala Asp Thr Thr 
865                 870                 875                 880 


Leu Thr Lys Ala Pro Val Ser Ser Thr Glu Ser Val Ile Gln Ser Asn 
                885                 890                 895     


Thr Pro Thr Pro Pro Pro Ser Gln Pro Leu Asn Glu Thr Ala Glu Glu 
            900                 905                 910         


Glu Ser Arg Ile Ser Ser Ser Pro Thr Leu Leu Glu Asn Ser Leu Glu 
        915                 920                 925             


Gln Thr Val Glu Pro Ser Glu Asp His Ser Glu Glu Glu Ser Glu Glu 
    930                 935                 940                 


Gly Ser Gly Asp Leu Gly Glu Pro Leu Tyr Glu Glu Pro Cys Asn Glu 
945                 950                 955                 960 


Ile Ser Lys Glu Gln Ala Lys Ala Thr Leu Leu Glu Asp Gln Gln Asp 
                965                 970                 975     


Pro Ser Pro Ser Ser 
            980     


<210>  885
<211>  3740
<212>  DNA
<213>  Homo Sapiens

<400>  885
gggacggcgg cggcgcagct cggaacccgc cagggtccag ggtccaggtt ccagcgcccg       60

gcggcccagg caccccccga gcccagctcc acacaccgtt cctggatctc ctctccccag      120

gcggagcgtg cccctgccca gtccagtgac cttcgcctgt tggagccctg gttaattttt      180

gcccagtctg cctgttgtgg ggctcctccc ctttggggat ataagcccgg cctggggctg      240

ctccgttctc tgcctggcct gaggctccct gagccgcctc cccaccatca ccatggccaa      300

gggcttctat atttccaagt ccctgggcat cctggggatc ctcctgggcg tggcagccgt      360

gtgcacaatc atcgcactgt cagtggtgta ctcccaggag aagaacaaga acgccaacag      420

ctcccccgtg gcctccacca ccccgtccgc ctcagccacc accaaccccg cctcggccac      480

caccttggac caaagtaaag cgtggaatcg ttaccgcctc cccaacacgc tgaaacccga      540

ttcctaccgg gtgacgctga gaccgtacct cacccccaat gacaggggcc tgtacgtttt      600

taagggctcc agcaccgtcc gtttcacctg caaggaggcc actgacgtca tcatcatcca      660

cagcaagaag ctcaactaca ccctcagcca ggggcacagg gtggtcctgc gtggtgtggg      720

aggctcccag ccccccgaca ttgacaagac tgagctggtg gagcccaccg agtacctggt      780

ggtgcacctc aagggctccc tggtgaagga cagccagtat gagatggaca gcgagttcga      840

gggggagttg gcagatgacc tggcgggctt ctaccgcagc gagtacatgg agggcaatgt      900

cagaaaggtg gtggccacta cacagatgca ggctgcagat gcccggaagt ccttcccatg      960

cttcgatgag ccggccatga aggccgagtt caacatcacg cttatccacc ccaaggacct     1020

gacagccctg tccaacatgc ttcccaaagg tcccagcacc ccacttccag aagaccccaa     1080

ctggaatgtc actgagttcc acaccacgcc caagatgtcc acgtacttgc tggccttcat     1140

tgtcagtgag ttcgactacg tggagaagca ggcatccaat ggtgtcttga tccggatctg     1200

ggcccggccc agtgccattg cggcgggcca cggcgattat gccctgaacg tgacgggccc     1260

catccttaac ttctttgctg gtcattatga cacaccctac ccactcccaa aatcagacca     1320

gattggcctg ccagacttca acgccggcgc catggagaac tggggactgg tgacctaccg     1380

ggagaactcc ctgctgttcg accccctgtc ctcctccagc agcaacaagg agcgggtggt     1440

cactgtgatt gctcatgagc tggcccacca gtggttcggg aacctggtga ccatagagtg     1500

gtggaatgac ctgtggctga acgagggctt cgcctcctac gtggagtacc tgggtgctga     1560

ctatgcggag cccacctgga acttgaaaga cctcatggtg ctgaatgatg tgtaccgcgt     1620

gatggcagtg gatgcactgg cctcctccca cccgctgtcc acacccgcct cggagatcaa     1680

cacgccggcc cagatcagtg agctgtttga cgccatctcc tacagcaagg gcgcctcagt     1740

cctcaggatg ctctccagct tcctgtccga ggacgtattc aagcagggcc tggcgtccta     1800

cctccacacc tttgcctacc agaacaccat ctacctgaac ctgtgggacc acctgcagga     1860

ggctgtgaac aaccggtcca tccaactccc caccaccgtg cgggacatca tgaaccgctg     1920

gaccctgcag atgggcttcc cggtcatcac ggtggatacc agcacgggga ccctttccca     1980

ggagcacttc ctccttgacc ccgattccaa tgttacccgc ccctcagaat tcaactacgt     2040

gtggattgtg cccatcacat ccatcagaga tggcagacag cagcaggact actggctgat     2100

agatgtaaga gcccagaacg atctcttcag cacatcaggc aatgagtggg tcctgctgaa     2160

cctcaatgtg acgggctatt accgggtgaa ctacgacgaa gagaactgga ggaagattca     2220

gactcagctg cagagagacc actcggccat ccctgtcatc aatcgggcac agatcattaa     2280

tgacgccttc aacctggcca gtgcccataa ggtccctgtc actctggcgc tgaacaacac     2340

cctcttcctg attgaagaga gacagtacat gccctgggag gccgccctga gcagcctgag     2400

ctacttcaag ctcatgtttg accgctccga ggtctatggc cccatgaaga actacctgaa     2460

gaagcaggtc acacccctct tcattcactt cagaaataat accaacaact ggagggagat     2520

cccagaaaac ctgatggacc agtacagcga ggttaatgcc atcagcaccg cctgctccaa     2580

cggagttcca gagtgtgagg agatggtctc tggccttttc aagcagtgga tggagaaccc     2640

caataataac ccgatccacc ccaacctgcg gtccaccgtc tactgcaacg ctatcgccca     2700

gggcggggag gaggagtggg acttcgcctg ggagcagttc cgaaatgcca cactggtcaa     2760

tgaggctgac aagctccggg cagccctggc ctgcagcaaa gagttgtgga tcctgaacag     2820

gtacctgagc tacaccctga acccggactt aatccggaag caggacgcca cctctaccat     2880

catcagcatt accaacaacg tcattgggca aggtctggtc tgggactttg tccagagcaa     2940

ctggaagaag ctttttaacg attatggtgg tggctcgttc tccttctcca acctcatcca     3000

ggcagtgaca cgacgattct ccaccgagta tgagctgcag cagctggagc agttcaagaa     3060

ggacaacgag gaaacaggct tcggctcagg cacccgggcc ctggagcaag ccctggagaa     3120

gacgaaagcc aacatcaagt gggtgaagga gaacaaggag gtggtgctcc agtggttcac     3180

agaaaacagc aaatagtccc cagcccttga agtcacccgg cccccatgca aggtgcccac     3240

atgtgtccat cccagcggct ggtgcagggc ctccattcct ggagcccgag gcaccagtgt     3300

cctcccctca aggacaaagt ctccagccca cgttctctct gcctgtgagc cagtctagtt     3360

cctgatgacc caggctgcct gagcacctcc cagcccctgc ccctcatgcc aaccccgccc     3420

taggcctggc atggcacctg tcgcccagtg ccctggggct gatctcaggg aagcccagct     3480

ccagggccag atgagcagaa gctctcgatg gacaatgaac ggccttgctg ggggccgccc     3540

tgtaccctct ttcacctttc cctaaagacc ctaaatctga ggaatcaaca gggcagcaga     3600

tctgtatatt tttttctaag agaaaatgta aataaaggat ttctagatga aaaaaaaaaa     3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3720

aaaaaaaaaa aaaaaaaaaa                                                 3740


<210>  886
<211>  967
<212>  PRT
<213>  Homo Sapiens

<400>  886

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  887
<211>  2944
<212>  DNA
<213>  Homo Sapiens

<400>  887
gtgcctacac tggtcccaca ggttttcagc tgtggagttt gggatctgag cttggagccc       60

atttgtttct ggcagttccg ctcatatttt ccacttgaag acatcgcctc ccttccttcc      120

aagctgggag accagaagtc aacaacagga gggtggagag gccgggtctc acaatccgct      180

tggctgggga gtccactgag gttcttgcat cctgaagcaa accatggaga gctggtgggg      240

acttccctgt cttgcgttcc tgtgttttct aatgcacgcc cgaggtcaaa gagactttga      300

tttggcagat gcccttgatg accctgaacc caccaagaag ccaaactcag atatctaccc      360

aaagccaaaa ccaccttact acccacagcc cgagaatccc gacagcggtg gaaatatcta      420

cccaaggcca aagccacgcc ctcaacccca gcctggcaat tccggcaaca gtggaggtta      480

cttcaatgat gtggaccgtg atgacggacg ctacccgccc aggcccaggc cacggccgcc      540

tgcaggaggt ggcggcggtg gctactccag ttatggcaac tccgacaaca cgcacggaag      600

agggggctat agactcaact ctcgttatgg aaatacttat ggtggagatc accattcaac      660

gtatggcaat ccagaaggca atatggtagc aaaaatcgtg tctcccatcg tatccgtggt      720

ggtggtgaca ctgctgggag cagcagccag ttatttcaaa ctaaacaata ggagaaattg      780

tttcaggacc catgaaccag aaaatgtctg aagatgttaa gatcccctga ttactttgag      840

aaaaacaact aaaacaagaa ccgtgtttat cactgttgtg gagatttcct tttattcttg      900

acacaatttg atgacctaaa gtgtgttttc ttctgtgtaa agtacatgag ctgcctcact      960

aagcattccc aactcattga atgtgatgtg gttataaaga taagttaggc agctagaccc     1020

tgcgttctaa aaaaggattg cttgcaatgt tggtttggct attcatttgc acaaagagac     1080

tgtggctctc tgttgtgaga tcttcagcta cctcatggtg caataacaca cacacgctta     1140

accatgttga tggcacaaag cggtgagcag tagggaggta gaatatcttg gtggggaggg     1200

gatgttatca gcttctggga gatgaagaat attgttgagg ttccaaagat gctggacctg     1260

tgctaaattc ttcagtgata tgaaaaaatc attgagcatt cattattgcg aatgaagtgg     1320

ggatgcatta tttctgacac ccacaagcag ggtttgatca tcctttcagc tttgagatat     1380

ctgcacataa aattattatt acctgaagaa aataaggctg cattttgaaa tgttaagtgc     1440

aaaatgactg atgttaaaac catctggggg aaatcttggg atgctttttc ctaggaaatc     1500

atatggttgt gatatgtttt ggcgcatagg agacagaaat agtgattatc aggcgttgag     1560

cctttttgta gtatttttag tctttgatac tctgtaagtg ctagttccta aggcaccaac     1620

attgcattcc ttggtttata ctttttctat tcatcagggt aggaagtctt aaatccttag     1680

gcatccaaga agtatactag ctttttgctt ctcttttaga aatacttgtg gggagagaaa     1740

aaaggatggt ttgggcatat tggtatagtt tgagtaaact aaggttaatg ttcatataac     1800

atttagactt tgccataaat atcagaacca aagatcaaga cattcatgta cagtctggaa     1860

tgtatatatg gggcccataa aaattcccag tatgcatgtt ttatgctcac cattatgaat     1920

tggggtcttc aaagagagaa ggttgaaagt ggaaagcact tgaaagggct ccccggtttg     1980

taaaatatct ttaatcattc acattaggta cctcggagtt gcgggtctca aatgtggatt     2040

catgcatcat ttgtgcagtt tgaagatagt ccatatttcc tatttcagta ttaggtcctg     2100

caacactttt caattcttgt agaaggtttt tttcaggagt ggtgatgtct gatgctcaat     2160

tactattttc cctataagag tttcagcatg agcttaatta aattcttgtg aaaaaacctg     2220

tgtttttagt tacacacaca cacacacaca cacctactta aatggaatct aaacattttt     2280

agcctttaat ccattccatt ttctaaaact gtcataaact atttttaatc attttaaata     2340

aatgtaaaag aaaaataact ggatttgatt attgaatagt ttttttctat atttcacaaa     2400

taaattgtat gaaatgactg tagaagtggc cccaaaatta tgaaccttcg tagctgtgaa     2460

tatgatgcca taaatctctt ttaaagctca agatagacta tgaacatatg aaatacatag     2520

ttacctaatc atgagactaa attcacctgg gtgacaaggc taacgttcaa gctacttaag     2580

atgaaaatat ttgaatcatg attgcttggg ggaacctctc tttgaggggt catgaggacc     2640

acctgctggg cattctgttt tcatgctgag aaggtgagaa ttgaacagat gagaaaagcc     2700

ttgataaaac gtcatctcca tgtaatttag agaaggataa ccttgactgt acagctgacc     2760

cttgaacaac acagggctga actgcacatg tccacctgta tgtgagtttg cttctggctc     2820

tgccattact gagacagcag gaccaaccct ccatctactc aatgggaaga tgataaggat     2880

gaagaccttt atggtgatcc gcttccactt aataaatagt aaattcatta aaaaaaaaaa     2940

aaaa                                                                  2944


<210>  888
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  888

Met Glu Ser Trp Trp Gly Leu Pro Cys Leu Ala Phe Leu Cys Phe Leu 
1               5                   10                  15      


Met His Ala Arg Gly Gln Arg Asp Phe Asp Leu Ala Asp Ala Leu Asp 
            20                  25                  30          


Asp Pro Glu Pro Thr Lys Lys Pro Asn Ser Asp Ile Tyr Pro Lys Pro 
        35                  40                  45              


Lys Pro Pro Tyr Tyr Pro Gln Pro Glu Asn Pro Asp Ser Gly Gly Asn 
    50                  55                  60                  


Ile Tyr Pro Arg Pro Lys Pro Arg Pro Gln Pro Gln Pro Gly Asn Ser 
65                  70                  75                  80  


Gly Asn Ser Gly Gly Tyr Phe Asn Asp Val Asp Arg Asp Asp Gly Arg 
                85                  90                  95      


Tyr Pro Pro Arg Pro Arg Pro Arg Pro Pro Ala Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Tyr Ser Ser Tyr Gly Asn Ser Asp Asn Thr His Gly Arg Gly Gly 
        115                 120                 125             


Tyr Arg Leu Asn Ser Arg Tyr Gly Asn Thr Tyr Gly Gly Asp His His 
    130                 135                 140                 


Ser Thr Tyr Gly Asn Pro Glu Gly Asn Met Val Ala Lys Ile Val Ser 
145                 150                 155                 160 


Pro Ile Val Ser Val Val Val Val Thr Leu Leu Gly Ala Ala Ala Ser 
                165                 170                 175     


Tyr Phe Lys Leu Asn Asn Arg Arg Asn Cys Phe Arg Thr His Glu Pro 
            180                 185                 190         


Glu Asn Val 
        195 


<210>  889
<211>  4976
<212>  DNA
<213>  Homo Sapiens

<400>  889
gggcgggcgg gccgcaggct gtcgggctgg ggctgaggct gaggctgagg ttgaggcggc       60

ggcggcggcg gccgggtgcc cgggacagcg acgcagcgcg ccggcggccg cgacagggcc      120

agcgagagcc ccgcagcccg ccgcagctgc cgcctcgccg cggccgggcc ggagagcacg      180

gcggcgggag cgcggcctta ggaggcggcc ggagcggtgg gcacagctcg gcgcggagcg      240

tcctgtcagg cggcggccga gggcgtcgcg gactctcccc gcgatgatgc cgatgatatt      300

aactgttttc ttgagcaaca atgaacagat tttaacagaa gttcctataa caccggaaac      360

aacctgtcga gatgttgtag aattttgcaa ggaacctgga gaaggcagct gccatttagc      420

tgaagtgtgg aggggaaatg aacgtcccat accctttgat catatgatgt acgaacatct      480

tcagaaatgg ggtccacgga gggaagaagt gaaatttttc cttcgacacg aggactcccc      540

aactgagaac agtgaacaag gtggccgtca gacccaagag caacgaactc agagaaatgt      600

aataaatgta cctggagaaa aacgtactga aaatggggtt gggaatccac gtgttgaact      660

taccctctca gagctccaag atatggcagc taggcaacag cagcagattg aaaatcagca      720

gcagatgttg gttgccaagg aacagcgttt acattttcta aagcaacagg agcgccgtca      780

gcagcagtct atttctgaaa atgaaaagct tcagaaattg aaagaacgag ttgaagccca      840

ggagaacaag ctgaagaaaa ttcgtgcaat gagaggacaa gtcgactaca gcaaaatcat      900

gaacggcaat ctgtctgctg aaatagaaag gttcagtgcc atgttccagg aaaagaagca      960

ggaagtacag actgcaattt taagggttga tcagcttagt cagcaattgg aagatttaaa     1020

gaaaggaaaa ctgaatgggt tccagtctta caatggcaaa ttgacgggac cagcggcggt     1080

ggagttaaaa agactgtacc aagaactaca gattcgtaac caacttaacc aggaacaaaa     1140

ttcaaaactt cagcagcaga aggaactctt aaataagcgc aacatggagg tggccatgat     1200

ggacaagcga atcagtgaac tgcgtgaacg tctctatggg aaaaaaattc agctgaaccg     1260

tgtgaatggc acgtcatcac cacagtcccc tctgagcaca tcgggcaggg tcgctgctgt     1320

ggggccttat atccaggttc ccagtgccgg aagctttcct gtgctggggg accctataaa     1380

gccccagtct ctcagtattg cctcaaatgc tgctcatgga agatccaaat ccgctaatga     1440

tggaaactgg ccaacattaa aacagaattc tagctcttcc gtgaaaccag tgcaggtggc     1500

cggtgcagac tggaaggatc cgagcgtgga ggggtctgtc aagcagggca ctgtctccag     1560

ccagcctgtg cccttctcag cactgggacc cacggagaag ccgggcatcg agattggtaa     1620

agtgccacct cccatcccgg gtgtaggcaa gcagctgcct ccaagctatg ggacataccc     1680

aagtcctaca cctctgggtc ctgggtcgac aagctccctg gaaaggagga aggaaggcag     1740

cttgcccagg cccagtgcag gcctgccaag tcgacagagg cccaccctgc tgcccgccac     1800

aggcagcacc ccccagccag gctcctcaca acagattcag cagaggattt ccgtaccgcc     1860

aagtcccacg tacccgccag cgggaccacc tgcatttcca gctggggaca gcaagcctga     1920

actcccactg acagtggcca ttaggccttt cctggctgat aaagggtcaa ggccacagtc     1980

tcccaggaaa ggaccccaga cagtgaattc aagttccata tactccatgt acctccagca     2040

agccacacca cctaagaatt accagccggc agcacacagc gccttaaata agtcagttaa     2100

agcagtgtat ggtaagcccg ttttaccttc gggttcaacc tctccatcgc cgctgccgtt     2160

tcttcacggg tcactgtcca cgggcacacc acagcctcag ccaccttcag aaagtactga     2220

gaaagagcct gagcaggatg gccccgccgc ccccgcagat ggcagcaccg tggagagcct     2280

gccacggcca ctcagcccca ccaagctcac gcccatcgtg cattcgccac tgcgctacca     2340

gagtgatgca gacctggagg ccctccgcag gaagctggcc aacgcgcccc ggcccctgaa     2400

aaagcgcagc tccatcacag agcccgaggg ccccggcggg cccaacatcc agaagctgct     2460

gtaccagcgc ttcaacaccc tggccggtgg catggagggc acccctttct accagcccag     2520

cccctcccag gacttcatgg gcaccttggc cgatgtggac aatggaaaca ccaatgccaa     2580

tggaaacctg gaagagctcc cccctgccca gcccacagcc ccactccccg ctgagcctgc     2640

cccgtcatca gatgccaatg ataatgagtt accttccccc gaaccagagg agctcatctg     2700

tccccaaacc acccaccaaa ctgccgagcc ggcagaggac aataacaaca acgtggccac     2760

ggtccccacc acggagcaga tcccgagtcc tgtggctgag gccccatctc caggggaaga     2820

gcaggtccct ccagcacctc ttccccctgc cagccaccct cctgccacct ccacgaacaa     2880

gcggaccaac ttgaagaagc ccaactcgga gcggacgggg cacgggctga gagtccggtt     2940

taaccccctg gcactgctcc tagacgcgtc tctggaagga gagttcgatc tggtgcagag     3000

gatcatctat gaggtggaag atcccagcaa gcccaacgac gaagggatca ccccactgca     3060

caacgccgtc tgcgccggcc accatcacat cgtgaagttc ctgctggatt ttggtgtcaa     3120

cgtgaatgct gctgatagtg atggatggac gccgctgcac tgcgctgcct cttgtaacag     3180

cgttcacctc tgcaaacagc tggtggagag tggtgccgcc atttttgcct caaccataag     3240

cgacattgaa actgctgcag acaagtgtga ggagatggag gaaggctaca tccagtgctc     3300

ccagtttcta tatggggtgc aggaaaagct gggtgtgatg aacaaaggtg tggcgtatgc     3360

tctgtgggac tacgaggccc agaacagtga cgagctgtcc ttccacgaag gggacgccct     3420

caccatcctg aggcgcaagg acgaaagcga gactgagtgg tggtgggctc gccttggaga     3480

ccgggagggc tatgtgccca aaaacctgct ggggctgtat ccacggatca aaccccgaca     3540

gcgaacactc gcctgaactt ccttttggag caccgcatgg tcttgccagc taccaggagc     3600

cacttaagag attattgtgc tgttttccag gaaagctgca gctagaaaat ggtcttaatg     3660

gtgctcactt tagcagacag cgtccacaat gtgaatccta cagtttccag gtgaggccct     3720

ttctccagtt tgcccattaa ctgggagagg tactttcgcc tccaaggact gaattttgcc     3780

aattactata aatccaaata aatacccact ttcaaaacac ccacccctct tgccattaag     3840

aagtcccata acccccggtt ggttgccagt gaagacagaa gctcttactg acttggcccc     3900

gaggccatca ccccctccag cagtgaacac tgtccgccgc tgtgaggcct gctcccctgc     3960

gaccgccctg ccccccgtca ccgaatcgga cactcatcct ttctcacact tcccacacat     4020

gatccttctt cccttcatca ccaaaggagc ctctgtatgg aaacatgtcc agtgttgctg     4080

cccagtgtgt atgcctccca gtacccactc tgctcggccg ccttgggggt tccgcttcct     4140

gttccagttc acctaaaggc tgattgtgca ggcccagcac tgtggctgga ctgccgcgcc     4200

acgggcacca ggacccctaa gaccaagtga caactgggag agcctcagca tatactcttc     4260

tcctccgatc tcacagcctg tcatgctgct cagtgtggtt ctcacccctg caagctcaaa     4320

ttcagttccc tgaatggagt caggtgctgg aggccgtggc agcggagggt ggttggggtt     4380

ggggctgggg gtggactggt gtgagggcag accagggcca ggtagacggg gctgtttggt     4440

gcctgaagga tggcagacgc ctggtgtcag gaggggccgc caccaaggag cagcagctgg     4500

ggcagaggag ctggggtcag gggccacccc tctctgccga tctccctgcc tgggctggct     4560

gtgaggccac ctttgtccca ggcccagcct caaggcaagg agggcgcttc actgaggtgt     4620

gaattgtacg tacaggcttt ttatatacca aaagtatttt ttgactagac cattcaaagc     4680

tacccgaact atgttggaaa tttttttttt ctcattaaaa tacaggccct taggctctat     4740

ttttcatgta tgagtcgtgt gtaatttatg taaaaatgtg tgtacagact cactgatgca     4800

gcactgtagc ccatcacctt ggagcactga ctgtacatag tgtggtgaag aaaagtgaac     4860

gcccttgtag agcagcccga ccacaggagc atggccgctg ccagcccaga cgctgctgac     4920

gctgtgtaaa tgtgcacaat aaacccgtct caccccggca aaaaaaaaaa aaaaaa         4976


<210>  890
<211>  1090
<212>  PRT
<213>  Homo Sapiens

<400>  890

Met Met Pro Met Ile Leu Thr Val Phe Leu Ser Asn Asn Glu Gln Ile 
1               5                   10                  15      


Leu Thr Glu Val Pro Ile Thr Pro Glu Thr Thr Cys Arg Asp Val Val 
            20                  25                  30          


Glu Phe Cys Lys Glu Pro Gly Glu Gly Ser Cys His Leu Ala Glu Val 
        35                  40                  45              


Trp Arg Gly Asn Glu Arg Pro Ile Pro Phe Asp His Met Met Tyr Glu 
    50                  55                  60                  


His Leu Gln Lys Trp Gly Pro Arg Arg Glu Glu Val Lys Phe Phe Leu 
65                  70                  75                  80  


Arg His Glu Asp Ser Pro Thr Glu Asn Ser Glu Gln Gly Gly Arg Gln 
                85                  90                  95      


Thr Gln Glu Gln Arg Thr Gln Arg Asn Val Ile Asn Val Pro Gly Glu 
            100                 105                 110         


Lys Arg Thr Glu Asn Gly Val Gly Asn Pro Arg Val Glu Leu Thr Leu 
        115                 120                 125             


Ser Glu Leu Gln Asp Met Ala Ala Arg Gln Gln Gln Gln Ile Glu Asn 
    130                 135                 140                 


Gln Gln Gln Met Leu Val Ala Lys Glu Gln Arg Leu His Phe Leu Lys 
145                 150                 155                 160 


Gln Gln Glu Arg Arg Gln Gln Gln Ser Ile Ser Glu Asn Glu Lys Leu 
                165                 170                 175     


Gln Lys Leu Lys Glu Arg Val Glu Ala Gln Glu Asn Lys Leu Lys Lys 
            180                 185                 190         


Ile Arg Ala Met Arg Gly Gln Val Asp Tyr Ser Lys Ile Met Asn Gly 
        195                 200                 205             


Asn Leu Ser Ala Glu Ile Glu Arg Phe Ser Ala Met Phe Gln Glu Lys 
    210                 215                 220                 


Lys Gln Glu Val Gln Thr Ala Ile Leu Arg Val Asp Gln Leu Ser Gln 
225                 230                 235                 240 


Gln Leu Glu Asp Leu Lys Lys Gly Lys Leu Asn Gly Phe Gln Ser Tyr 
                245                 250                 255     


Asn Gly Lys Leu Thr Gly Pro Ala Ala Val Glu Leu Lys Arg Leu Tyr 
            260                 265                 270         


Gln Glu Leu Gln Ile Arg Asn Gln Leu Asn Gln Glu Gln Asn Ser Lys 
        275                 280                 285             


Leu Gln Gln Gln Lys Glu Leu Leu Asn Lys Arg Asn Met Glu Val Ala 
    290                 295                 300                 


Met Met Asp Lys Arg Ile Ser Glu Leu Arg Glu Arg Leu Tyr Gly Lys 
305                 310                 315                 320 


Lys Ile Gln Leu Asn Arg Val Asn Gly Thr Ser Ser Pro Gln Ser Pro 
                325                 330                 335     


Leu Ser Thr Ser Gly Arg Val Ala Ala Val Gly Pro Tyr Ile Gln Val 
            340                 345                 350         


Pro Ser Ala Gly Ser Phe Pro Val Leu Gly Asp Pro Ile Lys Pro Gln 
        355                 360                 365             


Ser Leu Ser Ile Ala Ser Asn Ala Ala His Gly Arg Ser Lys Ser Ala 
    370                 375                 380                 


Asn Asp Gly Asn Trp Pro Thr Leu Lys Gln Asn Ser Ser Ser Ser Val 
385                 390                 395                 400 


Lys Pro Val Gln Val Ala Gly Ala Asp Trp Lys Asp Pro Ser Val Glu 
                405                 410                 415     


Gly Ser Val Lys Gln Gly Thr Val Ser Ser Gln Pro Val Pro Phe Ser 
            420                 425                 430         


Ala Leu Gly Pro Thr Glu Lys Pro Gly Ile Glu Ile Gly Lys Val Pro 
        435                 440                 445             


Pro Pro Ile Pro Gly Val Gly Lys Gln Leu Pro Pro Ser Tyr Gly Thr 
    450                 455                 460                 


Tyr Pro Ser Pro Thr Pro Leu Gly Pro Gly Ser Thr Ser Ser Leu Glu 
465                 470                 475                 480 


Arg Arg Lys Glu Gly Ser Leu Pro Arg Pro Ser Ala Gly Leu Pro Ser 
                485                 490                 495     


Arg Gln Arg Pro Thr Leu Leu Pro Ala Thr Gly Ser Thr Pro Gln Pro 
            500                 505                 510         


Gly Ser Ser Gln Gln Ile Gln Gln Arg Ile Ser Val Pro Pro Ser Pro 
        515                 520                 525             


Thr Tyr Pro Pro Ala Gly Pro Pro Ala Phe Pro Ala Gly Asp Ser Lys 
    530                 535                 540                 


Pro Glu Leu Pro Leu Thr Val Ala Ile Arg Pro Phe Leu Ala Asp Lys 
545                 550                 555                 560 


Gly Ser Arg Pro Gln Ser Pro Arg Lys Gly Pro Gln Thr Val Asn Ser 
                565                 570                 575     


Ser Ser Ile Tyr Ser Met Tyr Leu Gln Gln Ala Thr Pro Pro Lys Asn 
            580                 585                 590         


Tyr Gln Pro Ala Ala His Ser Ala Leu Asn Lys Ser Val Lys Ala Val 
        595                 600                 605             


Tyr Gly Lys Pro Val Leu Pro Ser Gly Ser Thr Ser Pro Ser Pro Leu 
    610                 615                 620                 


Pro Phe Leu His Gly Ser Leu Ser Thr Gly Thr Pro Gln Pro Gln Pro 
625                 630                 635                 640 


Pro Ser Glu Ser Thr Glu Lys Glu Pro Glu Gln Asp Gly Pro Ala Ala 
                645                 650                 655     


Pro Ala Asp Gly Ser Thr Val Glu Ser Leu Pro Arg Pro Leu Ser Pro 
            660                 665                 670         


Thr Lys Leu Thr Pro Ile Val His Ser Pro Leu Arg Tyr Gln Ser Asp 
        675                 680                 685             


Ala Asp Leu Glu Ala Leu Arg Arg Lys Leu Ala Asn Ala Pro Arg Pro 
    690                 695                 700                 


Leu Lys Lys Arg Ser Ser Ile Thr Glu Pro Glu Gly Pro Gly Gly Pro 
705                 710                 715                 720 


Asn Ile Gln Lys Leu Leu Tyr Gln Arg Phe Asn Thr Leu Ala Gly Gly 
                725                 730                 735     


Met Glu Gly Thr Pro Phe Tyr Gln Pro Ser Pro Ser Gln Asp Phe Met 
            740                 745                 750         


Gly Thr Leu Ala Asp Val Asp Asn Gly Asn Thr Asn Ala Asn Gly Asn 
        755                 760                 765             


Leu Glu Glu Leu Pro Pro Ala Gln Pro Thr Ala Pro Leu Pro Ala Glu 
    770                 775                 780                 


Pro Ala Pro Ser Ser Asp Ala Asn Asp Asn Glu Leu Pro Ser Pro Glu 
785                 790                 795                 800 


Pro Glu Glu Leu Ile Cys Pro Gln Thr Thr His Gln Thr Ala Glu Pro 
                805                 810                 815     


Ala Glu Asp Asn Asn Asn Asn Val Ala Thr Val Pro Thr Thr Glu Gln 
            820                 825                 830         


Ile Pro Ser Pro Val Ala Glu Ala Pro Ser Pro Gly Glu Glu Gln Val 
        835                 840                 845             


Pro Pro Ala Pro Leu Pro Pro Ala Ser His Pro Pro Ala Thr Ser Thr 
    850                 855                 860                 


Asn Lys Arg Thr Asn Leu Lys Lys Pro Asn Ser Glu Arg Thr Gly His 
865                 870                 875                 880 


Gly Leu Arg Val Arg Phe Asn Pro Leu Ala Leu Leu Leu Asp Ala Ser 
                885                 890                 895     


Leu Glu Gly Glu Phe Asp Leu Val Gln Arg Ile Ile Tyr Glu Val Glu 
            900                 905                 910         


Asp Pro Ser Lys Pro Asn Asp Glu Gly Ile Thr Pro Leu His Asn Ala 
        915                 920                 925             


Val Cys Ala Gly His His His Ile Val Lys Phe Leu Leu Asp Phe Gly 
    930                 935                 940                 


Val Asn Val Asn Ala Ala Asp Ser Asp Gly Trp Thr Pro Leu His Cys 
945                 950                 955                 960 


Ala Ala Ser Cys Asn Ser Val His Leu Cys Lys Gln Leu Val Glu Ser 
                965                 970                 975     


Gly Ala Ala Ile Phe Ala Ser Thr Ile Ser Asp Ile Glu Thr Ala Ala 
            980                 985                 990         


Asp Lys Cys Glu Glu Met Glu Glu  Gly Tyr Ile Gln Cys  Ser Gln Phe 
        995                 1000                 1005             


Leu Tyr  Gly Val Gln Glu Lys  Leu Gly Val Met Asn  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Ala Leu Trp Asp Tyr  Glu Ala Gln Asn Ser  Asp Glu Leu 
    1025                 1030                 1035             


Ser Phe  His Glu Gly Asp Ala  Leu Thr Ile Leu Arg  Arg Lys Asp 
    1040                 1045                 1050             


Glu Ser  Glu Thr Glu Trp Trp  Trp Ala Arg Leu Gly  Asp Arg Glu 
    1055                 1060                 1065             


Gly Tyr  Val Pro Lys Asn Leu  Leu Gly Leu Tyr Pro  Arg Ile Lys 
    1070                 1075                 1080             


Pro Arg  Gln Arg Thr Leu Ala  
    1085                 1090 


<210>  891
<211>  4801
<212>  DNA
<213>  Homo Sapiens

<400>  891
aaagggggaa aagaaagtgc ggcggaaagt aagaggctca ctggggaaga ctgccgggat       60

ccaggtctcc ggggtccgct ttggccagag gcgcggaagg aagcagtgcc cggcgacact      120

gcacccatcc cggctgcttt tgctgcgccc tctcagcttc ccaagaaagg catcgtcatg      180

tgatcatcac ctaagaacta gaacatcagc aggccctaga agcctcactc ttgcccctcc      240

ctttaatatc tcaaaggatg acacttctgt ggtgtgtagt gagtctctac ttttatggaa      300

tcctgcaaag tgatgcctca gaacgctgcg atgactgggg actagacacc atgaggcaaa      360

tccaagtgtt tgaagatgag ccagctcgca tcaagtgccc actctttgaa cacttcttga      420

aattcaacta cagcacagcc cattcagctg gccttactct gatctggtat tggactaggc      480

aggaccggga ccttgaggag ccaattaact tccgcctccc cgagaaccgc attagtaagg      540

agaaagatgt gctgtggttc cggcccactc tcctcaatga cactggcaac tatacctgca      600

tgttaaggaa cactacatat tgcagcaaag ttgcatttcc cttggaagtt gttcaaaaag      660

acagctgttt caattccccc atgaaactcc cagtgcataa actgtatata gaatatggca      720

ttcagaggat cacttgtcca aatgtagatg gatattttcc ttccagtgtc aaaccgacta      780

tcacttggta tatgggctgt tataaaatac agaattttaa taatgtaata cccgaaggta      840

tgaacttgag tttcctcatt gccttaattt caaataatgg aaattacaca tgtgttgtta      900

catatccaga aaatggacgt acgtttcatc tcaccaggac tctgactgta aaggtagtag      960

gctctccaaa aaatgcagtg ccccctgtga tccattcacc taatgatcat gtggtctatg     1020

agaaagaacc aggagaggag ctactcattc cctgtacggt ctattttagt tttctgatgg     1080

attctcgcaa tgaggtttgg tggaccattg atggaaaaaa acctgatgac atcactattg     1140

atgtcaccat taacgaaagt ataagtcata gtagaacaga agatgaaaca agaactcaga     1200

ttttgagcat caagaaagtt acctctgagg atctcaagcg cagctatgtc tgtcatgcta     1260

gaagtgccaa aggcgaagtt gccaaagcag ccaaggtgaa gcagaaagtg ccagctccaa     1320

gatacacagt ggaactggct tgtggttttg gagccacagt cctgctagtg gtgattctca     1380

ttgttgttta ccatgtttac tggctagaga tggtcctatt ttaccgggct cattttggaa     1440

cagatgaaac cattttagat ggaaaagagt atgatattta tgtatcctat gcaaggaatg     1500

cggaagaaga agaatttgta ttactgaccc tccgtggagt tttggagaat gaatttggat     1560

acaagctgtg catctttgac cgagacagtc tgcctggggg aattgtcaca gatgagactt     1620

tgagcttcat tcagaaaagc agacgcctcc tggttgttct aagccccaac tacgtgctcc     1680

agggaaccca agccctcctg gagctcaagg ctggcctaga aaatatggcc tctcggggca     1740

acatcaacgt cattttagta cagtacaaag ctgtgaagga aacgaaggtg aaagagctga     1800

agagggctaa gacggtgctc acggtcatta aatggaaagg ggaaaaatcc aagtatccac     1860

agggcaggtt ctggaagcag ctgcaggtgg ccatgccagt gaagaaaagt cccaggcggt     1920

ctagcagtga tgagcagggc ctctcgtatt catctttgaa aaatgtatga aaggaataat     1980

gaaaagggta aaaagaacaa ggggtgctcc aggaagaaag agtcccccca gtcttcattc     2040

gcagtttatg gtttcatagg caaaaataat ggtctaagcc tcccaatagg gataaattta     2100

gggtgactgt gtggctgact attctgcttc ctcaggcaac actaaagttt agaaagatat     2160

catcaacgtt ctgtcaccag tctctgatgc cactatgttc tttgcaggca aagacttgtt     2220

caatgcgaat ttccccttct acattgtcta tccctgtttt tatatgtctc cattcttttt     2280

aaaatcttaa catatggagc agcctttcct atgaatttaa atatgccttt aaaataagtc     2340

actgttgaca gggtcatgag tttccgagta tagttttctt tttatcttat ttttactcgt     2400

ccgttgaaaa gataatcaag gcctacattt tagctgagga taatgaactt ttttcctcat     2460

tcggctgtat aatacataac cacagcaaga ctgacatcca cttaggatga tacaaagcag     2520

tgtaactgaa aatgtttctt ttaattgatt taaaggactt gtcttctata ccacccttgt     2580

cctcatctca ggtaatttat gaaatctatg taaacttgaa aaatatttct taatttttgt     2640

ttttgctcca gtcaattcct gattatccac aggtcaaccc acattttttc attccttctc     2700

cctatctgct tatatcgcat tgctcattta gagtttgcag gaggctccat actaggttca     2760

gtctgaaaga aatctcctaa tggtgctata gagagggagg taacagaaag actcttttag     2820

ggcatttttc tgactcatga aaagagcaca gaaaaggatg tttggcaatt tgtcttttaa     2880

gtcttaacct tgctaatgtg aatactggga aagtgatttt ttctcactcg tttttgttgc     2940

tccattgtaa agggcggagg tcagtcttag tggccttgag agttgctttt ggcattaata     3000

ttctaagaga attaactgta tttcctgtca cctattcact agtgcaggaa atatacttgc     3060

tccaaataag tcagtatgag aagtcactgt caatgaaagt tgttttgttt gttttcagta     3120

atattttgct gtttttaaga cttggaaaac taagtgcaga gtttacagag tggtaaatat     3180

ctatgttaca tgtagattat acatatatat acacacgtgt atatgagata tatatcttat     3240

atctccacaa acacaaatta tatatataca tatccacaca catacattac atatatctgt     3300

gtatataaat ccacatgcac atgaaatata tatatatata taatttgtgt gtgtgtatgt     3360

gtatgtatat gactttaaat agctatgggt acaatattaa aaaccactgg aactcttgtc     3420

cagtttttaa attatgtttt tactggaatg tttttgtgtc agtgttttct gtacatatta     3480

tttgttaatt cacagctcac agagtgatag ttgtcatagt tcttgccttc cctaagttta     3540

tataaataac ttaagtattg ctacagttta tctaggttgc agtggcatct gctgtgcaca     3600

gagcttccat ggtcactgct aagcagtagc cagccatcgg gcattaattg atttcctact     3660

atattcccag cagacacatt tagaaactaa gctatgttaa cctcagtgct caactatttg     3720

aactgttgag tgataaagga aacaaatata actgtaaatg aatcttggta tcctgtgaaa     3780

cagaataatt cgtaatttaa gaaagccctt atcccggtaa catgaatgtt gatgaacaaa     3840

tgtaaaatta tatcctatat ttaagtaccc ataataaatc atttccctct ataagtgtta     3900

ttgattattt taaattgaaa aaagtttcac ttggatgaaa aaagtagaaa agtaggtcat     3960

tcttggatct actttttttt agccttatta atatttttcc ctattagaaa ccacaattac     4020

tccctctatt aacccttcac ttactagacc agaaaagaac ttattccaga taagctttga     4080

atatcaattc ttacataaac tttaggcaaa cagggaatag tctagtcacc aaaggaccat     4140

tctcttgcca atgctgcatt ccttttgcac ttttggattc catatttatc ccaaatgctg     4200

ttgggcaccc ctagaaatac cttgatgttt tttctattta tatgcctgcc tttggtactt     4260

aattttacaa atgctgtaat ataaagcata tcaagtttat gtgatacgta tcattgcaag     4320

agaatttgtt tcaagatttt tttttaatgt tccagaagat ggccaataga gaacattcaa     4380

gggaaatggg gaaacataat ttagagaaca agaacaaacc atgtctcaaa tttttttaaa     4440

aaaaattaat ggttttaaat atatgctata gggacgttcc atgcccaggt taacaaagaa     4500

ctgtgatata tagagtgtct aattacaaaa tcatatacga tttatttaat tctcttctgt     4560

attgtaactt agatgattcc caaggactct aataaaaaat cacttcattg tatttggaaa     4620

caaaaacatc attcattaat tacttatttt ctttccatag gttttaatat tttgagagtg     4680

tcttttttat ttcattcatg aacttttgta tttttcattt ttcatttgat ttgtaaattt     4740

acttatgtta aaaataaacc atttattttc agctttgaat tttaaaaaaa aaaaaaaaaa     4800

a                                                                     4801


<210>  892
<211>  570
<212>  PRT
<213>  Homo Sapiens

<400>  892

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  893
<211>  10661
<212>  DNA
<213>  Homo Sapiens

<400>  893
cgagatcccg gggagccagc ttgctgggag agcgggacgg tccggagcaa gcccagaggc       60

agaggaggcg acagagggaa aaagggccga gctagccgct ccagtgctgt acaggagccg      120

aagggacgca ccacgccagc cccagcccgg ctccagcgac agccaacgcc tcttgcagcg      180

cggcggcttc gaagccgccg cccggagctg ccctttcctc ttcggtgaag tttttaaaag      240

ctgctaaaga ctcggaggaa gcaaggaaag tgcctggtag gactgacggc tgcctttgtc      300

ctcctcctct ccaccccgcc tccccccacc ctgccttccc cccctccccc gtcttctctc      360

ccgcagctgc ctcagtcggc tactctcagc caacccccct caccaccctt ctccccaccc      420

gcccccccgc ccccgtcggc ccagcgctgc cagcccgagt ttgcagagag gtaactccct      480

ttggctgcga gcgggcgagc tagctgcaca ttgcaaagaa ggctcttagg agccaggcga      540

ctggggagcg gcttcagcac tgcagccacg acccgcctgg ttaggctgca cgcggagaga      600

accctctgtt ttcccccact ctctctccac ctcctcctgc cttccccacc ccgagtgcgg      660

agccagagat caaaagatga aaaggcagtc aggtcttcag tagccaaaaa acaaaacaaa      720

caaaaacaaa aaagccgaaa taaaagaaaa agataataac tcagttctta tttgcaccta      780

cttcagtgga cactgaattt ggaaggtgga ggattttgtt tttttctttt aagatctggg      840

catcttttga atctaccctt caagtattaa gagacagact gtgagcctag cagggcagat      900

cttgtccacc gtgtgtcttc ttctgcacga gactttgagg ctgtcagagc gctttttgcg      960

tggttgctcc cgcaagtttc cttctctgga gcttcccgca ggtgggcagc tagctgcagc     1020

gactaccgca tcatcacagc ctgttgaact cttctgagca agagaagggg aggcggggta     1080

agggaagtag gtggaagatt cagccaagct caaggatgga agtgcagtta gggctgggaa     1140

gggtctaccc tcggccgccg tccaagacct accgaggagc tttccagaat ctgttccaga     1200

gcgtgcgcga agtgatccag aacccgggcc ccaggcaccc agaggccgcg agcgcagcac     1260

ctcccggcgc cagtttgctg ctgctgcagc agcagcagca gcagcagcag cagcagcagc     1320

agcagcagca gcagcagcag cagcagcagc agcaagagac tagccccagg cagcagcagc     1380

agcagcaggg tgaggatggt tctccccaag cccatcgtag aggccccaca ggctacctgg     1440

tcctggatga ggaacagcaa ccttcacagc cgcagtcggc cctggagtgc caccccgaga     1500

gaggttgcgt cccagagcct ggagccgccg tggccgccag caaggggctg ccgcagcagc     1560

tgccagcacc tccggacgag gatgactcag ctgccccatc cacgttgtcc ctgctgggcc     1620

ccactttccc cggcttaagc agctgctccg ctgaccttaa agacatcctg agcgaggcca     1680

gcaccatgca actccttcag caacagcagc aggaagcagt atccgaaggc agcagcagcg     1740

ggagagcgag ggaggcctcg ggggctccca cttcctccaa ggacaattac ttagggggca     1800

cttcgaccat ttctgacaac gccaaggagt tgtgtaaggc agtgtcggtg tccatgggcc     1860

tgggtgtgga ggcgttggag catctgagtc caggggaaca gcttcggggg gattgcatgt     1920

acgccccact tttgggagtt ccacccgctg tgcgtcccac tccttgtgcc ccattggccg     1980

aatgcaaagg ttctctgcta gacgacagcg caggcaagag cactgaagat actgctgagt     2040

attccccttt caagggaggt tacaccaaag ggctagaagg cgagagccta ggctgctctg     2100

gcagcgctgc agcagggagc tccgggacac ttgaactgcc gtctaccctg tctctctaca     2160

agtccggagc actggacgag gcagctgcgt accagagtcg cgactactac aactttccac     2220

tggctctggc cggaccgccg ccccctccgc cgcctcccca tccccacgct cgcatcaagc     2280

tggagaaccc gctggactac ggcagcgcct gggcggctgc ggcggcgcag tgccgctatg     2340

gggacctggc gagcctgcat ggcgcgggtg cagcgggacc cggttctggg tcaccctcag     2400

ccgccgcttc ctcatcctgg cacactctct tcacagccga agaaggccag ttgtatggac     2460

cgtgtggtgg tggtgggggt ggtggcggcg gcggcggcgg cggcggcggc ggcggcggcg     2520

gcggcggcgg cggcgaggcg ggagctgtag ccccctacgg ctacactcgg ccccctcagg     2580

ggctggcggg ccaggaaagc gacttcaccg cacctgatgt gtggtaccct ggcggcatgg     2640

tgagcagagt gccctatccc agtcccactt gtgtcaaaag cgaaatgggc ccctggatgg     2700

atagctactc cggaccttac ggggacatgc gtttggagac tgccagggac catgttttgc     2760

ccattgacta ttactttcca ccccagaaga cctgcctgat ctgtggagat gaagcttctg     2820

ggtgtcacta tggagctctc acatgtggaa gctgcaaggt cttcttcaaa agagccgctg     2880

aagggaaaca gaagtacctg tgcgccagca gaaatgattg cactattgat aaattccgaa     2940

ggaaaaattg tccatcttgt cgtcttcgga aatgttatga agcagggatg actctgggag     3000

cccggaagct gaagaaactt ggtaatctga aactacagga ggaaggagag gcttccagca     3060

ccaccagccc cactgaggag acaacccaga agctgacagt gtcacacatt gaaggctatg     3120

aatgtcagcc catctttctg aatgtcctgg aagccattga gccaggtgta gtgtgtgctg     3180

gacacgacaa caaccagccc gactcctttg cagccttgct ctctagcctc aatgaactgg     3240

gagagagaca gcttgtacac gtggtcaagt gggccaaggc cttgcctggc ttccgcaact     3300

tacacgtgga cgaccagatg gctgtcattc agtactcctg gatggggctc atggtgtttg     3360

ccatgggctg gcgatccttc accaatgtca actccaggat gctctacttc gcccctgatc     3420

tggttttcaa tgagtaccgc atgcacaagt cccggatgta cagccagtgt gtccgaatga     3480

ggcacctctc tcaagagttt ggatggctcc aaatcacccc ccaggaattc ctgtgcatga     3540

aagcactgct actcttcagc attattccag tggatgggct gaaaaatcaa aaattctttg     3600

atgaacttcg aatgaactac atcaaggaac tcgatcgtat cattgcatgc aaaagaaaaa     3660

atcccacatc ctgctcaaga cgcttctacc agctcaccaa gctcctggac tccgtgcagc     3720

ctattgcgag agagctgcat cagttcactt ttgacctgct aatcaagtca cacatggtga     3780

gcgtggactt tccggaaatg atggcagaga tcatctctgt gcaagtgccc aagatccttt     3840

ctgggaaagt caagcccatc tatttccaca cccagtgaag cattggaaac cctatttccc     3900

caccccagct catgccccct ttcagatgtc ttctgcctgt tataactctg cactactcct     3960

ctgcagtgcc ttggggaatt tcctctattg atgtacagtc tgtcatgaac atgttcctga     4020

attctatttg ctgggctttt tttttctctt tctctccttt ctttttcttc ttccctccct     4080

atctaaccct cccatggcac cttcagactt tgcttcccat tgtggctcct atctgtgttt     4140

tgaatggtgt tgtatgcctt taaatctgtg atgatcctca tatggcccag tgtcaagttg     4200

tgcttgttta cagcactact ctgtgccagc cacacaaacg tttacttatc ttatgccacg     4260

ggaagtttag agagctaaga ttatctgggg aaatcaaaac aaaaacaagc aaacaaaaaa     4320

aaaaagcaaa aacaaaacaa aaaataagcc aaaaaacctt gctagtgttt tttcctcaaa     4380

aataaataaa taaataaata aatacgtaca tacatacaca catacataca aacatataga     4440

aatccccaaa gaggccaata gtgacgagaa ggtgaaaatt gcaggcccat ggggagttac     4500

tgattttttc atctcctccc tccacgggag actttatttt ctgccaatgg ctattgccat     4560

tagagggcag agtgacccca gagctgagtt gggcaggggg gtggacagag aggagaggac     4620

aaggagggca atggagcatc agtacctgcc cacagccttg gtccctgggg gctagactgc     4680

tcaactgtgg agcaattcat tatactgaaa atgtgcttgt tgttgaaaat ttgtctgcat     4740

gttaatgcct cacccccaaa cccttttctc tctcactctc tgcctccaac ttcagattga     4800

ctttcaatag tttttctaag acctttgaac tgaatgttct cttcagccaa aacttggcga     4860

cttccacaga aaagtctgac cactgagaag aaggagagca gagatttaac cctttgtaag     4920

gccccatttg gatccaggtc tgctttctca tgtgtgagtc agggaggagc tggagccaga     4980

ggagaagaaa atgatagctt ggctgttctc ctgcttagga cactgactga atagttaaac     5040

tctcactgcc actacctttt ccccaccttt aaaagacctg aatgaagttt tctgccaaac     5100

tccgtgaagc cacaagcacc ttatgtcctc ccttcagtgt tttgtgggcc tgaatttcat     5160

cacactgcat ttcagccatg gtcatcaagc ctgtttgctt cttttgggca tgttcacaga     5220

ttctctgtta agagccccca ccaccaagaa ggttagcagg ccaacagctc tgacatctat     5280

ctgtagatgc cagtagtcac aaagatttct taccaactct cagatcgctg gagcccttag     5340

acaaactgga aagaaggcat caaagggatc aggcaagctg ggcgtcttgc ccttgtcccc     5400

cagagatgat accctcccag caagtggaga agttctcact tccttcttta gagcagctaa     5460

aggggctacc cagatcaggg ttgaagagaa aactcaatta ccagggtggg aagaatgaag     5520

gcactagaac cagaaaccct gcaaatgctc ttcttgtcac ccagcatatc cacctgcaga     5580

agtcatgaga agagagaagg aacaaagagg agactctgac tactgaatta aaatcttcag     5640

cggcaaagcc taaagccaga tggacaccat ctggtgagtt tactcatcat cctcctctgc     5700

tgctgattct gggctctgac attgcccata ctcactcaga ttccccacct ttgttgctgc     5760

ctcttagtca gagggaggcc aaaccattga gactttctac agaaccatgg cttctttcgg     5820

aaaggtctgg ttggtgtggc tccaatactt tgccacccat gaactcaggg tgtgccctgg     5880

gacactggtt ttatatagtc ttttggcaca cctgtgttct gttgacttcg ttcttcaagc     5940

ccaagtgcaa gggaaaatgt ccacctactt tctcatcttg gcctctgcct ccttacttag     6000

ctcttaatct catctgttga actcaagaaa tcaagggcca gtcatcaagc tgcccatttt     6060

aattgattca ctctgtttgt tgagaggata gtttctgagt gacatgatat gatccacaag     6120

ggtttccttc cctgatttct gcattgatat taatagccaa acgaacttca aaacagcttt     6180

aaataacaag ggagagggga acctaagatg agtaatatgc caatccaaga ctgctggaga     6240

aaactaaagc tgacaggttc cctttttggg gtgggataga catgttctgg ttttctttat     6300

tattacacaa tctggctcat gtacaggatc acttttagct gttttaaaca gaaaaaaata     6360

tccaccactc ttttcagtta cactaggtta cattttaata ggtcctttac atctgttttg     6420

gaatgatttt catcttttgt gatacacaga ttgaattata tcattttcat atctctcctt     6480

gtaaatacta gaagctctcc tttacatttc tctatcaaat ttttcatctt tatgggtttc     6540

ccaattgtga ctcttgtctt catgaatata tgtttttcat ttgcaaaagc caaaaatcag     6600

tgaaacagca gtgtaattaa aagcaacaac tggattactc caaatttcca aatgacaaaa     6660

ctagggaaaa atagcctaca caagccttta ggcctactct ttctgtgctt gggtttgagt     6720

gaacaaagga gattttagct tggctctgtt ctcccatgga tgaaaggagg aggatttttt     6780

ttttcttttg gccattgatg ttctagccaa tgtaattgac agaagtctca ttttgcatgc     6840

gctctgctct acaaacagag ttggtatggt tggtatactg tactcacctg tgagggactg     6900

gccactcaga cccacttagc tggtgagcta gaagatgagg atcactcact ggaaaagtca     6960

caaggaccat ctccaaacaa gttggcagtg ctcgatgtgg acgaagagtg aggaagagaa     7020

aaagaaggag caccagggag aaggctccgt ctgtgctggg cagcagacag ctgccaggat     7080

cacgaactct gtagtcaaag aaaagagtcg tgtggcagtt tcagctctcg ttcattgggc     7140

agctcgccta ggcccagcct ctgagctgac atgggagttg ttggattctt tgtttcatag     7200

ctttttctat gccataggca atattgttgt tcttggaaag tttattattt ttttaactcc     7260

cttactctga gaaagggata ttttgaagga ctgtcatata tctttgaaaa aagaaaatct     7320

gtaatacata tatttttatg tatgttcact ggcactaaaa aatatagaga gcttcattct     7380

gtcctttggg tagttgctga ggtaattgtc caggttgaaa aataatgtgc tgatgctaga     7440

gtccctctct gtccatactc tacttctaaa tacatatagg catacatagc aagttttatt     7500

tgacttgtac tttaagagaa aatatgtcca ccatccacat gatgcacaaa tgagctaaca     7560

ttgagcttca agtagcttct aagtgtttgt ttcattaggc acagcacaga tgtggccttt     7620

ccccccttct ctcccttgat atctggcagg gcataaaggc ccaggccact tcctctgccc     7680

cttcccagcc ctgcaccaaa gctgcatttc aggagactct ctccagacag cccagtaact     7740

acccgagcat ggcccctgca tagccctgga aaaataagag gctgactgtc tacgaattat     7800

cttgtgccag ttgcccaggt gagagggcac tgggccaagg gagtggtttt catgtttgac     7860

ccactacaag gggtcatggg aatcaggaat gccaaagcac cagatcaaat ccaaaactta     7920

aagtcaaaat aagccattca gcatgttcag tttcttggaa aaggaagttt ctacccctga     7980

tgcctttgta ggcagatctg ttctcaccat taatcttttt gaaaatcttt taaagcagtt     8040

tttaaaaaga gagatgaaag catcacatta tataaccaaa gattacattg tacctgctaa     8100

gataccaaaa ttcataaggg caggggggga gcaagcatta gtgcctcttt gataagctgt     8160

ccaaagacag actaaaggac tctgctggtg actgacttat aagagctttg tgggtttttt     8220

tttccctaat aatatacatg tttagaagaa ttgaaaataa tttcgggaaa atgggattat     8280

gggtccttca ctaagtgatt ttataagcag aactggcttt ccttttctct agtagttgct     8340

gagcaaattg ttgaagctcc atcattgcat ggttggaaat ggagctgttc ttagccactg     8400

tgtttgctag tgcccatgtt agcttatctg aagatgtgaa acccttgctg ataagggagc     8460

atttaaagta ctagattttg cactagaggg acagcaggca gaaatcctta tttctgccca     8520

ctttggatgg cacaaaaagt tatctgcagt tgaaggcaga aagttgaaat acattgtaaa     8580

tgaatatttg tatccatgtt tcaaaattga aatatatata tatatatata tatatatata     8640

tatatatata tagtgtgtgt gtgtgttctg atagctttaa ctttctctgc atctttatat     8700

ttggttccag atcacacctg atgccatgta cttgtgagag aggatgcagt tttgttttgg     8760

aagctctctc agaacaaaca agacacctgg attgatcagt taactaaaag ttttctcccc     8820

tattgggttt gacccacagg tcctgtgaag gagcagaggg ataaaaagag tagaggacat     8880

gatacattgt actttactag ttcaagacag atgaatgtgg aaagcataaa aactcaatgg     8940

aactgactga gatttaccac agggaaggcc caaacttggg gccaaaagcc tacccaagtg     9000

attgaccagt ggccccctaa tgggacctga gctgttggaa gaagagaact gttccttggt     9060

cttcaccatc cttgtgagag aagggcagtt tcctgcattg gaacctggag caagcgctct     9120

atctttcaca caaattccct cacctgagat tgaggtgctc ttgttactgg gtgtctgtgt     9180

gctgtaattc tggttttgga tatgttctgt aaagattttg acaaatgaaa atgtgttttt     9240

ctctgttaaa acttgtcaga gtactagaag ttgtatctct gtaggtgcag gtccatttct     9300

gcccacaggt agggtgtttt tctttgatta agagattgac acttctgttg cctaggacct     9360

cccaactcaa ccatttctag gtgaaggcag aaaaatccac attagttact cctcttcaga     9420

catttcagct gagataacaa atcttttgga attttttcac ccatagaaag agtggtagat     9480

atttgaattt agcaggtgga gtttcatagt aaaaacagct tttgactcag ctttgattta     9540

tcctcatttg atttggccag aaagtaggta atatgcattg attggcttct gattccaatt     9600

cagtatagca aggtgctagg ttttttcctt tccccacctg tctcttagcc tggggaatta     9660

aatgagaagc cttagaatgg gtggcccttg tgacctgaaa cacttcccac ataagctact     9720

taacaagatt gtcatggagc tgcagattcc attgcccacc aaagactaga acacacacat     9780

atccatacac caaaggaaag acaattctga aatgctgttt ctctggtggt tccctctctg     9840

gctgctgcct cacagtatgg gaacctgtac tctgcagagg tgacaggcca gatttgcatt     9900

atctcacaac cttagccctt ggtgctaact gtcctacagt gaagtgcctg gggggttgtc     9960

ctatcccata agccacttgg atgctgacag cagccaccat cagaatgacc cacgcaaaaa    10020

aaagaaaaaa aaaattaaaa agtcccctca caacccagtg acacctttct gctttcctct    10080

agactggaac attgattagg gagtgcctca gacatgacat tcttgtgctg tccttggaat    10140

taatctggca gcaggaggga gcagactatg taaacagaga taaaaattaa ttttcaatat    10200

tgaaggaaaa aagaaataag aagagagaga gaaagaaagc atcacacaaa gattttctta    10260

aaagaaacaa ttttgcttga aatctcttta gatggggctc atttctcacg gtggcacttg    10320

gcctccactg ggcagcagga ccagctccaa gcgctagtgt tctgttctct ttttgtaatc    10380

ttggaatctt ttgttgctct aaatacaatt aaaaatggca gaaacttgtt tgttggacta    10440

catgtgtgac tttgggtctg tctctgcctc tgctttcaga aatgtcatcc attgtgtaaa    10500

atattggctt actggtctgc cagctaaaac ttggccacat cccctgttat ggctgcagga    10560

tcgagttatt gttaacaaag agacccaaga aaagctgcta atgtcctctt atcattgttg    10620

ttaatttgtt aaaacataaa gaaatctaaa atttcaaaaa a                        10661


<210>  894
<211>  920
<212>  PRT
<213>  Homo Sapiens

<400>  894

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  895
<211>  1476
<212>  DNA
<213>  Homo Sapiens

<400>  895
ccccgccggg ctcgcgccgc agaggccggt gaggcgccgg cggccacgcc gcggaaggcg       60

cgggccgagc agagccgggc gttggagccc gcgcgcgcat ggaggcgttg ccggcagccc      120

cctgagggca gcggggagac aagacccggc gacctcgcgc atccctcgag ccgccacgcg      180

ctctcgccac cgggcggcga cgggccgcgg agccggcgcg gccatggcga cgggcggcca      240

gcagaaggag aacacgctgc ttcacctctt cgccggcggg tgtggaggca cagttggtgc      300

tattttcact tgtccactag aagtcattaa gacacggttg cagtcttcaa gattagctct      360

ccggacagtc tactatcctc aggttcatct ggggaccatt agtggagctg gaatggtgag      420

accaacatcc gtgacacctg gactctttca ggttctgaag tcgatcttgg agaaagaggg      480

accaaagtca ctttttagag gcttgggtcc aaatttggtt ggagttgcac catcaagggc      540

tgtatacttt gcatgttact ccaaagccaa agagcaattt aatggcattt tcgtgcctaa      600

cagcaatatt gtgcatattt tctcagctgg ctctgcagct tttatcacaa attccttaat      660

gaatcctata tggatggtta aaacccgaat gcagctagaa cagaaagtga ggggctctaa      720

gcagatgaat acactccagt gtgctcgtta cgtttaccag accgaaggca ttcgtggctt      780

ctatagagga ttaactgcct cgtatgctgg aatttccgaa actataatct gctttgctat      840

ttatgaaagt ttaaagaagt atctgaaaga agctccatta gcctcttctg caaatgggac      900

tgagaaaaat tccacaagtt tttttggact tatggcagct gctgctcttt ctaagggctg      960

tgcctcctgc attgcttatc cacacgaagt cataaggacg aggctccggg aagagggcac     1020

caagtacaag tcttttgtcc agacggcgcg cctggtgttc cgggaagaag gctaccttgc     1080

cttttataga ggactgtttg cccagcttat ccggcagatc ccaaatactg ccattgtgtt     1140

gtctacttat gagttaattg tgtacctgtt agaagaccgt actcagtaac aggccggaaa     1200

attgtgctct agaagaataa aactgaaaaa ctctagagaa ttttttttcc ccattgatgt     1260

ttagaaagtt tgagactgaa acaggaaagg ccataaaata tctggttcat atcacctgtt     1320

ggacatttcc ttttggattc atgctttctg gaaggtttaa attcattaac gttaatagtt     1380

aattataact ttttttttaa cttaagagga ttcagggtta agcaccaact aaattaaatc     1440

atgctattta atttaagtat aaaaaaaaaa aaaaaa                               1476


<210>  896
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  896

Met Ala Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Leu Phe 
1               5                   10                  15      


Ala Gly Gly Cys Gly Gly Thr Val Gly Ala Ile Phe Thr Cys Pro Leu 
            20                  25                  30          


Glu Val Ile Lys Thr Arg Leu Gln Ser Ser Arg Leu Ala Leu Arg Thr 
        35                  40                  45              


Val Tyr Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala Gly Met 
    50                  55                  60                  


Val Arg Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser 
65                  70                  75                  80  


Ile Leu Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro 
                85                  90                  95      


Asn Leu Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr 
            100                 105                 110         


Ser Lys Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn 
        115                 120                 125             


Ile Val His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser 
    130                 135                 140                 


Leu Met Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln 
145                 150                 155                 160 


Lys Val Arg Gly Ser Lys Gln Met Asn Thr Leu Gln Cys Ala Arg Tyr 
                165                 170                 175     


Val Tyr Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala 
            180                 185                 190         


Ser Tyr Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu 
        195                 200                 205             


Ser Leu Lys Lys Tyr Leu Lys Glu Ala Pro Leu Ala Ser Ser Ala Asn 
    210                 215                 220                 


Gly Thr Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala 
225                 230                 235                 240 


Ala Leu Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val 
                245                 250                 255     


Ile Arg Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val 
            260                 265                 270         


Gln Thr Ala Arg Leu Val Phe Arg Glu Glu Gly Tyr Leu Ala Phe Tyr 
        275                 280                 285             


Arg Gly Leu Phe Ala Gln Leu Ile Arg Gln Ile Pro Asn Thr Ala Ile 
    290                 295                 300                 


Val Leu Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr 
305                 310                 315                 320 


Gln 
    


<210>  897
<211>  1060
<212>  DNA
<213>  Homo Sapiens

<400>  897
ctgagcgccc ggcccgaccc cggccatggg gtgctgctac agcagcgaga acgaggactc       60

ggaccaggac cgagaggagc ggaagctgct gctggaccct agcagccccc ctaccaaagc      120

tctcaatgga gccgagccca actaccacag cctgccttcc gctcgcactg atgagcaggc      180

cctgctctct tccatccttg ccaagacagc cagcaacatc attgatgtgt ctgctgcaga      240

ctcacagggc atggagcagc atgagtacat ggaccgtgcc aggcagtaca gcacccgctt      300

ggctgtgctg agcagcagcc tgacccattg gaagaagctg ccaccgctgc cgtctcttac      360

cagccagccc caccaagtgc tggccagtga gcccatcccg ttctctgatt tgcagcaggt      420

ctccaggata gctgcttatg cctacagtgc actttctcag atccgtgtgg acgcaaaaga      480

ggagctggtt gtacagtttg ggatcccatg aagagagggg tccttggaca gctcttctcc      540

tctcttcatc ccatctctac cccaccccct tggcccccag cctcactgcg gcttatacag      600

taccctaacc tgctactaat cacagagaaa aatgtgaaga aggaggagaa gaggaaggct      660

agaagcctga gcaagtgagg gtagaacctt ttgggactgg cctttgaagc tctggccagg      720

gatggggtgg gggccaaaag gacagagcct ggtatgtctt catagtcatt gagaatgtgg      780

agataccagt ttgggtgggg ggtgatcacc aggggaccta gggagatccc cttcccaccc      840

tctctgttgg cctcagagtc actcctgccc cctctccctg acttggtgct cacatgcacc      900

tcactagggt ttgtgaccag ggtctggatg agcttgaatt tgaatgaatt gagtttgtat      960

ttctagaacc ctgggttttt acatgtttgg tctttttttg ttttggtttg tcaccctcga     1020

taaaggaagt atattcatcc aaaaaaaaaa aaaaaaaaaa                           1060


<210>  898
<211>  161
<212>  PRT
<213>  Homo Sapiens

<400>  898

Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg 
1               5                   10                  15      


Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala 
            20                  25                  30          


Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr 
        35                  40                  45              


Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn 
    50                  55                  60                  


Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu 
65                  70                  75                  80  


Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser 
                85                  90                  95      


Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr 
            100                 105                 110         


Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp 
        115                 120                 125             


Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser 
    130                 135                 140                 


Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Ile 
145                 150                 155                 160 


Pro 
    


<210>  899
<211>  9159
<212>  DNA
<213>  Homo Sapiens

<400>  899
agccctcctc ccctttcccc gcccactccg ggctggcctt atccagtagc gtctgggtcc       60

ctggactaaa gccgtcaaat gtaaccaatt gctgaggagc tctcccctaa gaatcccgcc      120

tccactctga ggaacagctt cgctgatcaa tggatcccct cctagacgca atgagcgcgc      180

ggggcaagtg gagaagcggc tgaactgccc aatgaacaag cggtttccgt ggttaggggc      240

gtggcagaag cggtcgtcag gggcgtggcg gcagttactt gggcggggcc ggtagcggcg      300

ggagctgcac tggccagggg ttccggctgt atatccatga gcgccgctgg cagccgggga      360

gctgcaggaa ccagactggg ggcgagctga gcacctgtag tcaatcacac gcagaaataa      420

taatgatact tatgttagaa gattgttttg agaagtgcat ggagttacta catctgaagc      480

atttagaaca gtacctggca cagggttctg tcctcttcat ttgcaagcca ctgctttatc      540

cacgagggtg ctccctactt atgccagtga attaattttt ggcacagatg aatccttcat      600

atttatctgg atttagctgg tagcatttgt ctcctaagac ttggtcacag aggaatccat      660

gtgaccttca ggccttctgc tctaaactgg caggagatcc tgtttctact cacagcgtcc      720

gagggtctgg tggccgagcc ctgaggggcg ctgttgctcc caggtggcag aattcagcat      780

cagagagcca cacagctgaa agagatggat ggcttttagg tttgtttgaa taagagatct      840

gacctgaccg gcccaactgt acaactcttc aaggaaaatt cgtatttgca gtgggaagaa      900

taagtaacat tgatcaagat gaatgccatg ctggagactc ccgaactccc agccgtgttt      960

gatggagtga agctggctgc agtggctgct gtgctgtacg tgatcgtccg gtgtttgaac     1020

ctgaagagcc ccacagcccc acctgacctc tacttccagg actcggggct ctcacgcttt     1080

ctgctcaagt cctgtcctct tctgaccaaa gaatacattc caccgttgat ctgggggaaa     1140

agtggacaca tccagacagc cttgtatggg aagatgggaa gggtgaggtc gccacatcct     1200

tatgggcacc ggaagttcat cactatgtct gatggagcca cttctacatt cgacctcttc     1260

gagcccttgg ctgagcactg tgttggagat gatatcacca tggtcatctg ccctggaatt     1320

gccaatcaca gcgagaagca atacatccgc actttcgttg actacgccca gaaaaatggc     1380

tatcggtgcg ccgtgctgaa ccacctgggt gccctgccca acattgaatt gacctcgcca     1440

cgcatgttca cctatggctg cacgtgggaa tttggagcca tggtgaacta catcaagaag     1500

acatatcccc tgacccagct ggtcgtcgtg ggcttcagcc tgggtggtaa cattgtgtgc     1560

aaatacttgg gggagactca ggcaaaccaa gagaaggtcc tgtgctgcgt cagcgtgtgc     1620

caggggtaca gtgcactgag ggcccaggaa accttcatgc aatgggatca gtgccggcgg     1680

ttctacaact tcctcatggc tgacaacatg aagaagatca tcctctcgca caggcaagct     1740

ctttttggag accatgttaa gaaaccccag agcctggaag acacggactt gagccggctc     1800

tacacagcaa catccctgat gcagattgat gacaatgtga tgaggaagtt tcacggctat     1860

aactccctga aggaatacta tgaggaagaa agttgcatgc ggtacctgca caggatttat     1920

gttcctctca tgctggttaa tgcagctgac gatccgttgg tgcatgaaag tcttctaacc     1980

attccaaaat ctctttcaga gaaacgagag aacgtcatgt ttgtgctgcc tctgcatggg     2040

ggccacttgg gcttctttga gggctctgtg ctgttccccg agcccctgac atggatggat     2100

aagctggtgg tggagtacgc caacgccatt tgccaatggg agcgtaacaa gttgcagtgc     2160

tctgacacgg agcaggtgga ggccgacctg gagtgaggcc tccggactct ggcacgctcc     2220

agcagccctc ctctggaagc tgcgtcccct caccccctgt ttcaggtctc ccatctccct     2280

cagtgacctg gatctgacct cacaccatca gcagggggca cccaccatgc acacctgtct     2340

cggagtaggc agctcttcct gggagctcca ggctattttt gtgcttagtt actggttttc     2400

tccattgcat tgttaggcat ggtgacaagt gacagagttc ttgccctctg tccagtttca     2460

gcatctggtt gcttttaagc caagtacatc tagtttccct attaaaaatg tgtctgaata     2520

gcgattttgc tttgccacca aaaggctttt ccctgagaac agtgaaggat gtatgtcatt     2580

ttgtggtggt tgtatgtgtc cttacataga ccttaaaaag agctcaccct tccaggccaa     2640

tgctgaagac acagctccgc ttgggagcct gagaacccag gcttcccagg ccagagtgtg     2700

gcttcttaaa cggcaaagga aattcctttg agtcacaagc caagttttcg ccctgtctcc     2760

tgagaccatt tccctacgct ttgctgctgc tgagagttac gtgaggcact tgttaaaaat     2820

tcagcctccc aggtccctcc cctcggagag gctgattcac tgggtctggg aaggagcctg     2880

gggattttaa tttttcacaa gtgccccaga tgattctcat caccaagcaa attttggaaa     2940

tgctgttcaa cagcgccctt aaattggaaa catctttgca gctcgtttta ttgaaattca     3000

taatcagggg tgtcctctag ctcccacggt ctccagagca gcaaggccgg ctatggagct     3060

gccgtcgtgt gaccacagtg tgatgtctca gaagggctct gggtgggctg agcatctggg     3120

ctgtgccctg gctctgcttt tcaccctgga caaagtcgct gtggacttca atttcttcac     3180

ctctaaaatg ggggacttgg accaggtaga ttgctgagct cactaccagg ttcaaagttc     3240

aatgacaaac tcagtttact gaggtttgag agaacatccc tccaggggag cctgggagct     3300

gctctcccag tctaagcatg tagatatcat cgtttgcctt ttgtgtgtgt gtgtccctta     3360

tttgataaaa agatgttttg agttgttttt tttttaagca ctcacttgta attttagttt     3420

ttaaacccaa gtccctctaa ctttgccttt gataccaaac aattcaaaag ttggatctga     3480

gtttggagaa agatatttcc aacctaagtg ggtattattt tgaaaccaga tttttaattt     3540

aatagcctat atttgtagtc tgttggatag gtgtttccaa agtgtgtctt ctcaagtgaa     3600

aacgcaactc taggtttcaa gtactccttt tctccgatcc tgtggtactt gaatatccaa     3660

aaaccctgca ctttgaacaa tcagctgttg ctatctggaa ctaaacagaa ctatgagtaa     3720

aattgcctgg atactttaaa aagatatttt tcctccttca tctcctttga ctccaggaca     3780

gactggaata taagtagtgg gtctgcatgg atgtttcagg gatcaaagga gccacctggg     3840

cgcctgagtg ccaaccctca gggccacagg tgggtgtggt ttgggcacgg gtccaagtga     3900

ctgtgacggg acccgtgggc atgggtccag gtctgtaacc tgaagaagtt gttttctgac     3960

aatcaccaaa tcatccgaat gacatcaaaa gcagccctta tctcagagac tgagatttct     4020

gtggtctcaa cttcgctttg gtataatttc tggcactcac cagcctctat cattatgact     4080

ttccccccag tgtattattt ctctaatagg tttccttttc acgttctttt agcacagact     4140

ggcactttac cctctcagtt tggaagttag cccctctcct ctgttacttt tcccttcacc     4200

caactacagc tgtgatctag aacattcata gtcatatttc tgctactact accttcattt     4260

atcaagactt tttatgagaa taggtaaacc aagcaataac ttcctaggac tgaatcacca     4320

ccccagaaga gcgagaggct cctttcatat gcctgaggcc acacccctta acctgttctg     4380

acaaaatagt ggctggccca tgtaccagct ccattcagaa attcaggaag agaaaagaca     4440

gccctgttgt cacacaaacc ggtgtggggg agggtggagc ctggtctgca cggcagtcct     4500

ggtggcccct gtggaggaca ggcagggctg gcagcatagc ctttgttgcc acacaaccgg     4560

aatttgctcc cccaggactg tgggagccag tgtcccagct gaaatctttt tagtgtgtgg     4620

ctctgaatgg cactcacatt ccattttggc tcacatgaaa ctaactgaag ccctttgttc     4680

aagcttcagg ctcttaggca tggaaatgag aatgtgactg tggctgtctt acaggaaaat     4740

tcttgtttgt ccctgaatga gagcacagag gcattgaatt cacagagctg caaacttgcc     4800

tgataaatga gggagtggca gtttatagat aggtcatctt ttttccttcc tccaggtgtc     4860

cttgcctttc ttcccaaagt cattcatttc tgatgagtat atgaatcccc ctcttgctag     4920

taaggttcta tttgggctaa aacaaggctg aatttttaaa gagtatttga atatatttta     4980

gaatcaaatt gaggctataa attgcatcaa tctggacaat tccattgcag gaataatatg     5040

ttaaaaacca atggggagaa gcacccacat ctctcctgta gcactccgtg tctcataagc     5100

aatttgaaga cacttacaag taactgattc cagtcaaatt aggattaact gactcaaaaa     5160

atggtgtcaa gtttctttaa tgtttttatg ttagaagtga gtttaacaga cttgaagaaa     5220

actgttatct tttcctgctg tgagtttaca caaatgattc cagagcagaa tgaaagcaga     5280

aagctgttgg ttacaatatt cttttaacct ctctgcagca ttttacactt actgggaacc     5340

ttatgattca ccgtaagagt ggaaatatac ctgagttcgt gtcctaatgg tctctaattc     5400

acattggatc gtgggcaaat cacctcacct ctctgagcct gttccctcct cttagaccat     5460

ctctaagacc acttcatcta tttacacatc atttgcttga acattgctga acatctgcgt     5520

gaacttggcc tctccagccc ttgcaggtgg aaacagctgt gtcaaggctc aaggctcacg     5580

ctgaggggac ttggagggag ggggcttctg cattaagctt tcctggtgaa gacccttgat     5640

cttgtccaaa gccctgtgtc tttgactggc ttctcttcag agtccccgtt gtcatcgtaa     5700

gacccttgct gtttggaggg tggtcttgtg actgtggcag ctgctggccg ctggaatgag     5760

gagcctatct ccatcctcca gtgtgactca ggcagagcat tgagaattcc cagggcagaa     5820

atccttcctg ctcaggcttt cattctaaaa ctacagtctt cattaaagct gaactttctg     5880

ggtagctgag cttatatgcc cggcatctga atgagagctc tctttgtaac tgtgtgactt     5940

gagatctagt ttgccagctc ctgggaaaca atacatgtgt tcttgtttgt gtttgctcag     6000

caagcagatg tctgagatgt aagaagcttt tcttttcctg tggcattgat tctgacttag     6060

agctgaagta aaagatcact gaaacatcac gtcaagttga agtcactcat aggtctttgt     6120

cctttaggca ggacaggaga gtcattaaga agcatttcac tgtagcattc tatcacaata     6180

tcatctggaa ttgttttctt tgcccagaaa gccttaactt gcctctagag aatccctggt     6240

attacaacga tattgcggca ttagaattcc aactcttctg ctgtggaagt ttgaagcgaa     6300

gctgcagcaa aaccagagaa tttcctcaag tggcctgtag gctccttgtt atcttatgcc     6360

cccacccctc cctcaacaat atgagtgatc cagaactggc ccaaacacct cagctctggt     6420

ccctttttgc ccttcttggc cttactctgt tgttcaaagc cactttggat tgcttggatg     6480

cttcgaacag ccatgaaaag tagcctgcct gtggcattta gaggccaagc aattgacaga     6540

aagggtttct tctacctctg ttatctaagc agagggaagt aaacctctca ccgcccccca     6600

cccctcactg cccccgatta ccctagaatt gctttcgcca aattgtagtt gaagctaagg     6660

aaggggaatc tggcccctgc tgggagaggg aactggaatg ccacacaagg caaggcctgc     6720

ttccttcctt cccctctgct gctgctgcct cggaacgctg cagcccaggc ttcctcccac     6780

agtggccctt ggaagcaggc cgcagagtag acagctgctc cttttggaag agtcagtccc     6840

ctgtgttttc tgaactgttt ttcctagcat gtatgtgggt agagctttca tgcatctcta     6900

gtaataataa gctgaaatta gttttttttt taattctcca atttaaaact tttaattaaa     6960

aagtaaattt taatgtcgaa aatgcaaact tggggagggc agaaagatca cacacaaggc     7020

tgtcacttca tacttgcagg attgcacagc agccgggcag aggcgctcct cacttcccag     7080

atggggcggc gggcagcaga gacgcacctc acttcctaga cagtgcggca gccaggcaca     7140

ggcacacctc acttcccaga cagttgggcg gccaggcaag cgctcctcac ttcccagatg     7200

gggcggctcc cgggaagcgg ggctcctcac ttcccagaca gggtggccag gcagaggtgc     7260

tcctcacttc ccagaacaat tctttatgaa tttgataaag gactgaagtg caactgaaag     7320

ctgctagtga tgatctggta atatacaatt tgtccagtag ccagtttgtt tttattgtgt     7380

tttctaacca taagagatca ttaaaggcaa agcctgtatg acgctgtaca cacacaaaaa     7440

aatggtcacc gcaggccata ctaccaatga aatggtaggt aaacaaatct tctggtcaag     7500

agaaaaaaaa aagaaatagc actctgcatg ctttgctcta caagacgaat ttccctagaa     7560

agaatccaat gaaggccggg catagtggct cactcctgta atcccagcac tttggaggcc     7620

gaggcgggta gatcacctga ggttaggagt tcaagaccag cctggccaac atggtgaaac     7680

cccttctcta ctaaaaatgc aaaaattagc tgggtgtggt ggcgggcgcc tgtaatccca     7740

gctactcggg aggctgaggt gggagaattg cttgaaccca ggagacggag gttgcagtga     7800

gccgagatca cgcctctgca ctccagcctg ggcaacaaga gtgagactcc gtctccaaaa     7860

aaagaaaagg aatccagtga aaatggctgc aattacaaca agaagtgaag gaagaagact     7920

ggtgacatct ctgaaggatg cagttgaggt tgatccaggt ttatccgaat atgctacctt     7980

tctgagcctt aaaccttcat ctctcaggtg ttgatttgct tctgatagct tcatcatttc     8040

tccctgaagt cttttacact cttctgttag tttccttgtt tcagtatcat gaagtgaagc     8100

actgtgtggt tgtggcgtgg gcccgtcttg cttagatgca ttcagtggga cagctttgct     8160

gggttccatg tcattcaatt tatcattttc attggggatc tccatttgga atccattaat     8220

tcatgaggtt ttgcctcatt ccacacagct tccatatctg aagtgtttag tggagcaaaa     8280

attgtaccat aaacttgtgt ttactctttt cattcggatc atagtcaaag ggctgtagca     8340

ttactgaaac agtcacagtt gaccctgggt caataattcc actgttgggc ctcacacagt     8400

accggtgagg cacggtagtc ttcactttga aacacacttt tctatccgat ggatttcgca     8460

atttaagatt tgtagtgact acatctgtga aggggccttt gaatttgagg tctatgggcg     8520

ggtcgaggac caggatctgc tcgtgcttcg ccgtggcccc ggaggcagac gccattggag     8580

agacagcgca gagcaggggg cggcttgctc gctgggggcg ggggacgatg gcgagagggg     8640

agggggagcg agttcgcatc tctccttttc ctggttagac tctgttcaac cacattctta     8700

tgttggcaga tctgcttcca gattgatttt tagagcacca tcactttcac attcctgatt     8760

ctgattttgt tttgttttgt ttgggttttc tgaaacttaa aatgctgccc cgaaaatact     8820

atatttttga gtttgtgttc tgaaagcctc cgtgctgctg gatctttggg gggaaataca     8880

ggatccttca gcactgaggt gtttaagatt tgcaactagc aatgcaattt tttctaaata     8940

tggggatatt tacctttatt aagaaattat actaaacatt gatgtccttg atcattttat     9000

gttctcatat tacttttgat tctactatga ttgtgtggtg gtgaacaaag atcattacaa     9060

acaaaaactg taattttgtt atatttgatt caatggaatt tacctaaaaa ataaagacta     9120

aaaatgtggt gtgaaaaaaa aaaaaaaaaa aaaaaaaaa                            9159


<210>  900
<211>  425
<212>  PRT
<213>  Homo Sapiens

<400>  900

Met Asn Ala Met Leu Glu Thr Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Thr Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Thr Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Thr 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Thr Met Ser Asp Gly Ala Thr Ser Thr Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Thr Met 
        115                 120                 125             


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140                 


Thr Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160 


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Thr Ser Pro Arg Met 
                165                 170                 175     


Phe Thr Tyr Gly Cys Thr Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190         


Lys Lys Thr Tyr Pro Leu Thr Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205             


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Thr Gln Ala Asn Gln 
    210                 215                 220                 


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240 


Arg Ala Gln Glu Thr Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255     


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270         


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285             


Thr Asp Leu Ser Arg Leu Tyr Thr Ala Thr Ser Leu Met Gln Ile Asp 
    290                 295                 300                 


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320 


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335     


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350         


Leu Thr Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365             


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380                 


Leu Phe Pro Glu Pro Leu Thr Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400 


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415     


Thr Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425 


<210>  901
<211>  4979
<212>  DNA
<213>  Homo Sapiens

<400>  901
ggcgctctcg gctagctgca gcggcggcgg cgcggagggg aaggcatcca ggatgcggtg       60

cggggcggcc cggtgccccc ccgccccgtc acggcagccg cggcggccga ggggaccggg      120

ccagggccgg gggcggcggc ccgagccgcg gtagcggcgg cggcgggagg ggcggcctga      180

gggcggacgg gcgggcgccc gggttgcggg ggctcggtgc cgctccgcac tgcccggccg      240

gtctcggccc cggcgccatg agtggcggcg gcggcggagg gggctcggcg cccagtcgct      300

tcgccgacta ctttgtcatc tgcggactgg acacggagac cgggctggag ccggacgagc      360

tgtcggcatt atgccagtac atacaggctt ctaaagccag ggatggtgcc agccctttca      420

tttcaagtac gactgaagga gaaaattttg agcagacacc attgagaaga acattcaaat      480

ctaaggtcct tgcacgatat cctgagaacg tagaatggaa tccctttgac caagatgcag      540

taggaatgct atgtatgccg aaagggctgg cattcaagac ccaggctgat cccagggagc      600

cccaattcca tgcctttatt atcacaaggg aggatggctc tcggacattt gggtttgccc      660

tcacatttta tgaagaggtg actagcaagc agatctgcag tgcaatgcag accctctacc      720

acatgcacaa tgctgagtat gatgtcctac atgctccccc tgctgatgac agagaccaga      780

gcagcatgga ggatggtgaa gacactcctg tgaccaaact gcagcgcttc aactcctatg      840

acattagccg ggacactctc tacgtctcta agtgcatctg cctcatcaca cccatgtctt      900

tcatgaaggc atgtcggagc gtgctggagc aactccacca ggcagtcact tcacctcagc      960

cccctccact gccccttgag agctacatat acaacgtact ctacgaggtg ccgctcccac     1020

ctcctggccg gtccttgaag ttttctgggg tctatgggcc aataatctgc cagagaccaa     1080

gtaccaatga gcttccccta tttgactttc ctgtcaaaga ggtttttgaa ctgctcgggg     1140

tggagaatgt gtttcagctt tttacttgtg cccttctgga gtttcaaatc ctgctctact     1200

cacagcatta ccagagactg atgactgtgg cggagacgat tacagctctc atgtttcctt     1260

tccagtggca gcatgtctat gtccctattc tcccagcttc tctcctgcat ttcttagatg     1320

ctcctgttcc atacctgatg ggtttgcatt ccaatggcct ggatgaccgg tcaaagctgg     1380

agctgcctca agaggctaac ctctgctttg tggacattga caaccacttc attgagttgc     1440

cagaggactt gccacagttc cccaacaaat tggagtttgt ccaggaagtc tctgagattc     1500

tcatggcatt tggaattccc cctgaaggga atcttcattg cagtgagagt gcctccaagc     1560

tgaagaggct gcgggcctct gagcttgtct cggacaagag gaatgggaac attgctggct     1620

cccctttgca ttcctacgag cttcttaagg agaatgaaac tattgcccgg ctgcaagcct     1680

tggtcaagag aactggggtg agcctggaaa agttggaagt gcgtgaagac cccagcagca     1740

ataaggatct caaagttcag tgtgatgaag aagaactcag gatttaccag ctaaacattc     1800

agatccggga agtttttgca aatcgtttca ctcagatgtt tgcagattat gaggtgtttg     1860

tcatccaacc cagccaggat aaggaatcct ggtttaccaa cagggagcaa atgcaaaact     1920

ttgataaagc atcttttctg tcagatcagc ctgagcccta cctgcccttc ctctcaagat     1980

tcctggagac ccagatgttt gcatctttca ttgacaacaa aataatgtgt catgatgatg     2040

atgataaaga ccctgtactc cgggtatttg attcccgagt tgacaagatc aggctgttga     2100

atgttcggac acctactctc cgtacatcca tgtaccagaa gtgtaccact gtggatgaag     2160

cagagaaagc aattgagctg cgtctggcaa aaattgacca tactgcaatt cacccacatt     2220

tacttgacat gaagattgga caagggaaat atgagccggg cttcttccct aagctgcagt     2280

ctgatgtact ttccactggg ccagccagca acaagtggac gaaaaggaat gcccctgccc     2340

agtggaggcg gaaagatcgg cagaagcagc acacagaaca cctgcgttta gataatgacc     2400

agagggagaa gtacatccag gaagccagga ctatgggcag cactatccgc cagcccaaac     2460

tgtccaacct ctctccatca gtgattgccc agaccaattg gaagtttgta gagggcctgc     2520

tgaaggaatg ccgcaataag accaagagga tgctggtgga aaagatgggc cgagaagctg     2580

tggagctagg gcatggggag gtgaacatca caggggtgga agagaacacc ctgattgcca     2640

gcctttgtga tctcctggaa aggatctgga gtcatggact acaagtgaaa caggggaaat     2700

cagccttatg gtcccacctg ttacattatc aggacaaccg gcagagaaaa ctcacatcag     2760

gaagcctcag tacctcagga atacttcttg attcagaacg taggaagtct gatgccagct     2820

cactcatgcc tcccctgagg atctccctga ttcaggatat gaggcacatc cagaacatcg     2880

gggaaatcaa gactgatgtg ggaaaggcca gagcatgggt gcgactgtcc atggaaaaaa     2940

agttactttc cagacacctg aagcagctcc tctcagacca tgagctcacc aaaaagttat     3000

ataagcgcta tgccttcctg cgctgtgatg acgagaagga gcagttcctc tatcacctcc     3060

tgtctttcaa tgccgtcgat tacttttgct tcaccaatgt cttcacaact atcctgatcc     3120

cgtaccacat tctgatcgta ccaagcaaga agctgggggg ctccatgttc actgccaacc     3180

catggatctg tatatcagga gaattgggtg agacacagat catgcagatt cccaggaatg     3240

tgctagagat gaccttcgag tgccagaact tggggaagct tactactgtc cagattggcc     3300

atgataactc tgggctgtat gccaaatggc tggtggagta tgtgatggtc aggaatgaga     3360

tcacaggaca tacctacaag ttcccgtgtg gccggtggtt agggaagggc atggatgatg     3420

gaagcctgga gcggatccta gttggggagc tgctcacatc ccagcctgag gtggatgaga     3480

ggccatgccg gaccccgccg ctgcagcagt cccccagtgt catccggagg cttgttacca     3540

tctcacccaa caacaagccc aagctgaaca ctgggcagat ccaggagtcc atcggggagg     3600

cagtcaatgg cattgtgaag cacttccata agcctgagaa agagcgaggc agtctgacgc     3660

tgttgctctg tggagagtgt ggccttgtct cggccttgga acaggctttc cagcatggat     3720

ttaaatcgcc ccggctcttc aaaaatgtct tcatttggga tttcctggaa aaagcacaaa     3780

cctattatga gacattagag aagaatgaag tagtccctga ggaaaactgg catacaagag     3840

cccggaactt ctgccgattt gtcactgcaa tcaacaatac tccccggaac atcggcaagg     3900

atggcaagtt tcagatgctg gtgtgcttgg gagccagaga tcacctccta caccactgga     3960

ttgccctgct ggctgactgc cccatcactg cacacatgta tgaggatgtg gcactgatca     4020

aagaccatac acttgtcaat tccttgattc gtgtgctgca gacattgcag gagttcaaca     4080

tcacgctgga gacgtccctt gtcaagggca tcgacatctg acctcccagc accagccagc     4140

agcaggactg agaaagactc accctgcagc tctgaccttt tttcccaaag ggacttaagc     4200

gattgtgcag gagtaggaga caaaatgtac actcactgta aaaagaaaac tagaggattt     4260

ttggaataaa taatctattt tagagtttat ttgctgattt gctttttaca cactttcatg     4320

tgaaagagtg atagggagag ggagcgaggc tggtgccgct tattttgaag ctggtgccct     4380

ccctcgccgt ggccacatgc tggaagcctg aggcctccct ggactgagcc tgtggcactg     4440

cgtgcgggac agttatgttt ccttgccccg tcgcattaat gaggcccttc cacatcattt     4500

ttaaactaat gtttttctat attaacatta ttatggatat ttggctttca taggccacac     4560

acaggtgtgc tgcgcgggaa gccccatgct ccaatcaaag ggatttttag tagtgcctct     4620

aagcaagcac cgatgagtca gtcccacgta ttttcttttt tgtcagtatt gtttgggaag     4680

gagacatgcc gggatgtgtc atcgtgccaa ataccacatt tcctgttggc acagtttcac     4740

agaagtaaac ataagcatgt tttaacaggt ttttcttttc ttttttcttt tttaaaatgt     4800

tttatttatt taacccgcca ttgtgtgttt ttaagtattt tcttttttta aggaaaggaa     4860

aagcttgtca caatctaact ggctatgtta ttattattaa atttatgttt tgcaacttag     4920

aaaccagcta cagtatggcc cacttaataa aacacctgaa acaaaaaaaa aaaaaaaaa      4979


<210>  902
<211>  1287
<212>  PRT
<213>  Homo Sapiens

<400>  902

Met Ser Gly Gly Gly Gly Gly Gly Gly Ser Ala Pro Ser Arg Phe Ala 
1               5                   10                  15      


Asp Tyr Phe Val Ile Cys Gly Leu Asp Thr Glu Thr Gly Leu Glu Pro 
            20                  25                  30          


Asp Glu Leu Ser Ala Leu Cys Gln Tyr Ile Gln Ala Ser Lys Ala Arg 
        35                  40                  45              


Asp Gly Ala Ser Pro Phe Ile Ser Ser Thr Thr Glu Gly Glu Asn Phe 
    50                  55                  60                  


Glu Gln Thr Pro Leu Arg Arg Thr Phe Lys Ser Lys Val Leu Ala Arg 
65                  70                  75                  80  


Tyr Pro Glu Asn Val Glu Trp Asn Pro Phe Asp Gln Asp Ala Val Gly 
                85                  90                  95      


Met Leu Cys Met Pro Lys Gly Leu Ala Phe Lys Thr Gln Ala Asp Pro 
            100                 105                 110         


Arg Glu Pro Gln Phe His Ala Phe Ile Ile Thr Arg Glu Asp Gly Ser 
        115                 120                 125             


Arg Thr Phe Gly Phe Ala Leu Thr Phe Tyr Glu Glu Val Thr Ser Lys 
    130                 135                 140                 


Gln Ile Cys Ser Ala Met Gln Thr Leu Tyr His Met His Asn Ala Glu 
145                 150                 155                 160 


Tyr Asp Val Leu His Ala Pro Pro Ala Asp Asp Arg Asp Gln Ser Ser 
                165                 170                 175     


Met Glu Asp Gly Glu Asp Thr Pro Val Thr Lys Leu Gln Arg Phe Asn 
            180                 185                 190         


Ser Tyr Asp Ile Ser Arg Asp Thr Leu Tyr Val Ser Lys Cys Ile Cys 
        195                 200                 205             


Leu Ile Thr Pro Met Ser Phe Met Lys Ala Cys Arg Ser Val Leu Glu 
    210                 215                 220                 


Gln Leu His Gln Ala Val Thr Ser Pro Gln Pro Pro Pro Leu Pro Leu 
225                 230                 235                 240 


Glu Ser Tyr Ile Tyr Asn Val Leu Tyr Glu Val Pro Leu Pro Pro Pro 
                245                 250                 255     


Gly Arg Ser Leu Lys Phe Ser Gly Val Tyr Gly Pro Ile Ile Cys Gln 
            260                 265                 270         


Arg Pro Ser Thr Asn Glu Leu Pro Leu Phe Asp Phe Pro Val Lys Glu 
        275                 280                 285             


Val Phe Glu Leu Leu Gly Val Glu Asn Val Phe Gln Leu Phe Thr Cys 
    290                 295                 300                 


Ala Leu Leu Glu Phe Gln Ile Leu Leu Tyr Ser Gln His Tyr Gln Arg 
305                 310                 315                 320 


Leu Met Thr Val Ala Glu Thr Ile Thr Ala Leu Met Phe Pro Phe Gln 
                325                 330                 335     


Trp Gln His Val Tyr Val Pro Ile Leu Pro Ala Ser Leu Leu His Phe 
            340                 345                 350         


Leu Asp Ala Pro Val Pro Tyr Leu Met Gly Leu His Ser Asn Gly Leu 
        355                 360                 365             


Asp Asp Arg Ser Lys Leu Glu Leu Pro Gln Glu Ala Asn Leu Cys Phe 
    370                 375                 380                 


Val Asp Ile Asp Asn His Phe Ile Glu Leu Pro Glu Asp Leu Pro Gln 
385                 390                 395                 400 


Phe Pro Asn Lys Leu Glu Phe Val Gln Glu Val Ser Glu Ile Leu Met 
                405                 410                 415     


Ala Phe Gly Ile Pro Pro Glu Gly Asn Leu His Cys Ser Glu Ser Ala 
            420                 425                 430         


Ser Lys Leu Lys Arg Leu Arg Ala Ser Glu Leu Val Ser Asp Lys Arg 
        435                 440                 445             


Asn Gly Asn Ile Ala Gly Ser Pro Leu His Ser Tyr Glu Leu Leu Lys 
    450                 455                 460                 


Glu Asn Glu Thr Ile Ala Arg Leu Gln Ala Leu Val Lys Arg Thr Gly 
465                 470                 475                 480 


Val Ser Leu Glu Lys Leu Glu Val Arg Glu Asp Pro Ser Ser Asn Lys 
                485                 490                 495     


Asp Leu Lys Val Gln Cys Asp Glu Glu Glu Leu Arg Ile Tyr Gln Leu 
            500                 505                 510         


Asn Ile Gln Ile Arg Glu Val Phe Ala Asn Arg Phe Thr Gln Met Phe 
        515                 520                 525             


Ala Asp Tyr Glu Val Phe Val Ile Gln Pro Ser Gln Asp Lys Glu Ser 
    530                 535                 540                 


Trp Phe Thr Asn Arg Glu Gln Met Gln Asn Phe Asp Lys Ala Ser Phe 
545                 550                 555                 560 


Leu Ser Asp Gln Pro Glu Pro Tyr Leu Pro Phe Leu Ser Arg Phe Leu 
                565                 570                 575     


Glu Thr Gln Met Phe Ala Ser Phe Ile Asp Asn Lys Ile Met Cys His 
            580                 585                 590         


Asp Asp Asp Asp Lys Asp Pro Val Leu Arg Val Phe Asp Ser Arg Val 
        595                 600                 605             


Asp Lys Ile Arg Leu Leu Asn Val Arg Thr Pro Thr Leu Arg Thr Ser 
    610                 615                 620                 


Met Tyr Gln Lys Cys Thr Thr Val Asp Glu Ala Glu Lys Ala Ile Glu 
625                 630                 635                 640 


Leu Arg Leu Ala Lys Ile Asp His Thr Ala Ile His Pro His Leu Leu 
                645                 650                 655     


Asp Met Lys Ile Gly Gln Gly Lys Tyr Glu Pro Gly Phe Phe Pro Lys 
            660                 665                 670         


Leu Gln Ser Asp Val Leu Ser Thr Gly Pro Ala Ser Asn Lys Trp Thr 
        675                 680                 685             


Lys Arg Asn Ala Pro Ala Gln Trp Arg Arg Lys Asp Arg Gln Lys Gln 
    690                 695                 700                 


His Thr Glu His Leu Arg Leu Asp Asn Asp Gln Arg Glu Lys Tyr Ile 
705                 710                 715                 720 


Gln Glu Ala Arg Thr Met Gly Ser Thr Ile Arg Gln Pro Lys Leu Ser 
                725                 730                 735     


Asn Leu Ser Pro Ser Val Ile Ala Gln Thr Asn Trp Lys Phe Val Glu 
            740                 745                 750         


Gly Leu Leu Lys Glu Cys Arg Asn Lys Thr Lys Arg Met Leu Val Glu 
        755                 760                 765             


Lys Met Gly Arg Glu Ala Val Glu Leu Gly His Gly Glu Val Asn Ile 
    770                 775                 780                 


Thr Gly Val Glu Glu Asn Thr Leu Ile Ala Ser Leu Cys Asp Leu Leu 
785                 790                 795                 800 


Glu Arg Ile Trp Ser His Gly Leu Gln Val Lys Gln Gly Lys Ser Ala 
                805                 810                 815     


Leu Trp Ser His Leu Leu His Tyr Gln Asp Asn Arg Gln Arg Lys Leu 
            820                 825                 830         


Thr Ser Gly Ser Leu Ser Thr Ser Gly Ile Leu Leu Asp Ser Glu Arg 
        835                 840                 845             


Arg Lys Ser Asp Ala Ser Ser Leu Met Pro Pro Leu Arg Ile Ser Leu 
    850                 855                 860                 


Ile Gln Asp Met Arg His Ile Gln Asn Ile Gly Glu Ile Lys Thr Asp 
865                 870                 875                 880 


Val Gly Lys Ala Arg Ala Trp Val Arg Leu Ser Met Glu Lys Lys Leu 
                885                 890                 895     


Leu Ser Arg His Leu Lys Gln Leu Leu Ser Asp His Glu Leu Thr Lys 
            900                 905                 910         


Lys Leu Tyr Lys Arg Tyr Ala Phe Leu Arg Cys Asp Asp Glu Lys Glu 
        915                 920                 925             


Gln Phe Leu Tyr His Leu Leu Ser Phe Asn Ala Val Asp Tyr Phe Cys 
    930                 935                 940                 


Phe Thr Asn Val Phe Thr Thr Ile Leu Ile Pro Tyr His Ile Leu Ile 
945                 950                 955                 960 


Val Pro Ser Lys Lys Leu Gly Gly Ser Met Phe Thr Ala Asn Pro Trp 
                965                 970                 975     


Ile Cys Ile Ser Gly Glu Leu Gly Glu Thr Gln Ile Met Gln Ile Pro 
            980                 985                 990         


Arg Asn Val Leu Glu Met Thr Phe  Glu Cys Gln Asn Leu  Gly Lys Leu 
        995                 1000                 1005             


Thr Thr  Val Gln Ile Gly His  Asp Asn Ser Gly Leu  Tyr Ala Lys 
    1010                 1015                 1020             


Trp Leu  Val Glu Tyr Val Met  Val Arg Asn Glu Ile  Thr Gly His 
    1025                 1030                 1035             


Thr Tyr  Lys Phe Pro Cys Gly  Arg Trp Leu Gly Lys  Gly Met Asp 
    1040                 1045                 1050             


Asp Gly  Ser Leu Glu Arg Ile  Leu Val Gly Glu Leu  Leu Thr Ser 
    1055                 1060                 1065             


Gln Pro  Glu Val Asp Glu Arg  Pro Cys Arg Thr Pro  Pro Leu Gln 
    1070                 1075                 1080             


Gln Ser  Pro Ser Val Ile Arg  Arg Leu Val Thr Ile  Ser Pro Asn 
    1085                 1090                 1095             


Asn Lys  Pro Lys Leu Asn Thr  Gly Gln Ile Gln Glu  Ser Ile Gly 
    1100                 1105                 1110             


Glu Ala  Val Asn Gly Ile Val  Lys His Phe His Lys  Pro Glu Lys 
    1115                 1120                 1125             


Glu Arg  Gly Ser Leu Thr Leu  Leu Leu Cys Gly Glu  Cys Gly Leu 
    1130                 1135                 1140             


Val Ser  Ala Leu Glu Gln Ala  Phe Gln His Gly Phe  Lys Ser Pro 
    1145                 1150                 1155             


Arg Leu  Phe Lys Asn Val Phe  Ile Trp Asp Phe Leu  Glu Lys Ala 
    1160                 1165                 1170             


Gln Thr  Tyr Tyr Glu Thr Leu  Glu Lys Asn Glu Val  Val Pro Glu 
    1175                 1180                 1185             


Glu Asn  Trp His Thr Arg Ala  Arg Asn Phe Cys Arg  Phe Val Thr 
    1190                 1195                 1200             


Ala Ile  Asn Asn Thr Pro Arg  Asn Ile Gly Lys Asp  Gly Lys Phe 
    1205                 1210                 1215             


Gln Met  Leu Val Cys Leu Gly  Ala Arg Asp His Leu  Leu His His 
    1220                 1225                 1230             


Trp Ile  Ala Leu Leu Ala Asp  Cys Pro Ile Thr Ala  His Met Tyr 
    1235                 1240                 1245             


Glu Asp  Val Ala Leu Ile Lys  Asp His Thr Leu Val  Asn Ser Leu 
    1250                 1255                 1260             


Ile Arg  Val Leu Gln Thr Leu  Gln Glu Phe Asn Ile  Thr Leu Glu 
    1265                 1270                 1275             


Thr Ser  Leu Val Lys Gly Ile  Asp Ile 
    1280                 1285         


<210>  903
<211>  2867
<212>  DNA
<213>  Homo Sapiens

<400>  903
ggtgtttgga gagcccggac tggatgccca ctagaatcct gtgctgtgaa cagtgagaga       60

gttttcttca ttttgaggaa ccctaaacac ctatctttcc caaggcaacc tgtctggact      120

gagcatttct ctgacttgac ataacttccc atccagccag gagtctgcac tcttcagtct      180

ttgcaggcag tagcagaatc ccatggtagc caggtgggtg aaggggagcg aggacgttct      240

acctgccttg aagaagacac ctgacctgcg gagtgagtga ccagtgtttc cagagcctgg      300

caatggatgc cattcacatc ggcatgtcca gcacccccct ggtgaagcac actgctgggg      360

ctgggctcaa ggccaacaga ccccgcgtca tgtccaagag tgggcacagc aacgtgagaa      420

ttgacaaagt ggatggcata tacctactct acctgcaaga cctgtggacc acagttatcg      480

acatgaagtg gagatacaaa ctcaccctgt tcgctgccac ttttgtgatg acctggttcc      540

tttttggagt catctactat gccatcgcgt ttattcatgg ggacttagaa cccggtgagc      600

ccatttcaaa tcataccccc tgcatcatga aagtggactc tctcactggg gcgtttctct      660

tttccctgga atcccagaca accattggct atggagtccg ttccatcaca gaggaatgtc      720

ctcatgccat cttcctgttg gttgctcagt tggtcatcac gaccttgatt gagatcttca      780

tcaccggaac cttcctggcc aaaatcgcca gacccaaaaa gcgggctgag accatcaagt      840

tcagccactg tgcagtcatc accaagcaga atgggaagct gtgcttggtg attcaggtag      900

ccaatatgag gaagagcctc ttgattcagt gccagctctc tggcaagctc ctgcagaccc      960

acgtcaccaa ggagggggag cggattctcc tcaaccaagc cactgtcaaa ttccacgtgg     1020

actcctcctc tgagagcccc ttcctcattc tgcccatgac attctaccat gtgctggatg     1080

agacgagccc cctgagagac ctcacacccc aaaacctaaa ggagaaggag tttgagcttg     1140

tggtcctcct caatgccact gtggaatcca ccagcgctgt ctgccagagc cgaacatctt     1200

atatcccaga ggaaatctac tggggttttg agtttgtgcc tgtggtatct ctctccaaaa     1260

atggaaaata tgtggctgat ttcagtcagt ttgaacagat tcggaaaagc ccagattgca     1320

cattttactg tgcagattct gagaaacagc aactcgagga gaagtacagg caggaggatc     1380

agagggaaag agaactgagg acacttttat tacaacagag caatgtctga tcacaggggc     1440

gccatccagg tttaaccctg caagctgttt ccacatcaga actcccttca aacacaaaga     1500

ttgctgtgaa aacgaaaatg tgtagacgca ctctcaaaaa ctgcacggac atacaaaatc     1560

aatcttttcc tttgatcttg tggctaaacc agcatttctg tgtttgagag atttcctgtt     1620

aggtgcttcg tctgaaagtg aactctcata attcaaattg tataaaataa agctacattt     1680

ctaagagctt ggtgtagggc aattggaata atgtcctgtt agataaacag acatttagca     1740

atcctgacat taaaaggaaa tgtatttcta tacaagatta ttagctgtaa tacaagatat     1800

ttatttaacc aatgacctta tggctgagag ttgaattgtg gttcagtatt cattgatctc     1860

actgctttaa aacatgctct ttttgttcaa gcaggaaaaa tattatatct aattatgtct     1920

atgtggtaat acctaaaaag aggtagagag actctatgtt cacaaaatat agtaatttca     1980

tttttacctt tcttcagtgg actgaattgt atggaaggaa attgatcaga tctgtaattc     2040

acaactgtgg aaacctacac aaatggggct gatgccattg tttcctctat tttattttat     2100

ttatttttga atccactatc tctttccatt caaaatattt ccattcaaaa tgtggttcac     2160

agacccgcca catcagcacc atccgagagc ttattagtaa tgtgtagatt ctcatgtccc     2220

agccagactt acagaattgg ggtctgtatc ttaacaagaa ccccagatga tttgtgtaca     2280

aatgaaagtt cgaaagctgt gctctggaca gtgttctcaa agcaactttc tgaagccgtg     2340

tggaaaactg actctgtgtg ggtcccgtat ccctgtggca tccagacctg gcctctcttc     2400

atttcattat tattggccaa tatttctttc agccatttca tttcttatct attaaaatgg     2460

cttgcccata aaggaactgc ataggattat cccctgacat tccaagagca aaataaagct     2520

cttgagagta attgttgtct cagtcatgct tgctgattac agttagcaca aaagaaaaat     2580

tcagctgcct gacaatacag gaaatgttct cagatgctga tgtttgtaag gtccggtggg     2640

gccatgagga agaagaggag ctgaaggtaa gaaactcata aacaagatga ctctttgatg     2700

catgaacaag atttgaaaat ctcaagcctg taaagaatac ccctgctatt taaataaagc     2760

tcataccaag aggtaacatt ttgccccggg ccaaattcag gggtctagtg ccctgcattc     2820

ctttgaggca aaaaataaat gggctatgac tggttaaatg tccaaaa                   2867


<210>  904
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  904

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  905
<211>  3646
<212>  DNA
<213>  Homo Sapiens

<400>  905
acatgcgtcc cgagcccgcc agaagctgct aggctgaggc tgctgtcccg gcgggagctg       60

tggcgcggag cggcccctct gctgcgtctg ccctcgtttt gtctcacgac tcacactcag      120

tgctccattc cccaagagtt cgcgttcccc gcgcggcggt cgagaggcgg ctgcccgcgg      180

tcccgcgcgg gcgcggggcg atggcggcgc gggggtcagg gccccgcgcg ctccgcctgc      240

tgctcttggt ccagctggtc gcggggcgct gcggtctagc gggcgcggcg ggcggcgcgc      300

agagaggatt atctgaacct tcttctattg caaaacatga agatagtttg cttaaggatt      360

tatttcaaga ctacgaaaga tgggttcgtc ctgtggaaca cctgaatgac aaaataaaaa      420

taaaatttgg acttgcaata tctcaattgg tggatgtgga tgagaaaaat cagttaatga      480

caacaaacgt ctggttgaaa caggaatgga tagatgtaaa attaagatgg aaccctgatg      540

actatggtgg aataaaagtt atacgtgttc cttcagactc tgtctggaca ccagacatcg      600

ttttgtttga taatgcagat ggacgttttg aagggaccag tacgaaaaca gtcatcaggt      660

acaatggcac tgtcacctgg actccaccgg caaactacaa aagttcctgt accatagatg      720

tcacgttttt cccatttgac cttcagaact gttccatgaa atttggttct tggacttatg      780

atggatcaca ggttgatata attctagagg accaagatgt agacaagaga gatttttttg      840

ataatggaga atgggagatt gtgagtgcaa cagggagcaa aggaaacaga accgacagct      900

gttgctggta tccgtatgtc acttactcat ttgtaatcaa gcgcctgcct ctcttttata      960

ccttgttcct tataataccc tgtattgggc tctcattttt aactgtactt gtcttctatc     1020

ttccttcaaa tgaaggtgaa aagatttgtc tctgcacttc agtacttgtg tctttgactg     1080

tcttccttct ggttattgaa gagatcatac catcatcttc aaaagtcata cctctaattg     1140

gagagtatct ggtatttacc atgatttttg tgacactgtc aattatggta accgtcttcg     1200

ctatcaacat tcatcatcgt tcttcctcaa cacataatgc catggcgcct ttggtccgca     1260

agatatttct tcacacgctt cccaaactgc tttgcatgag aagtcatgta gacaggtact     1320

tcactcagaa agaggaaact gagagtggta gtggaccaaa atcttctaga aacacattgg     1380

aagctgcgct cgattctatt cgctacatta caagacacat catgaaggaa aatgatgtcc     1440

gtgaggttgt tgaagattgg aaattcatag cccaggttct tgatcggatg tttctgtgga     1500

cttttctttt cgtttcaatt gttggatctc ttgggctttt tgttcctgtt atttataaat     1560

gggcaaatat attaatacca gttcatattg gaaatgcaaa taagtgaagc ctcccaaggg     1620

actgaagtat acatttagtt aacacacata tatctgatgg cacctataaa attatgaaaa     1680

tgtaagttat gtgttaaatt tagtgcaagc tttaacagac taagttgcta acctcaattt     1740

atgttaacag atgatccatt tgaacagttg gctgtatgac tgaagtaata actgatgaga     1800

tacatttgat cttgtaaaaa tagcaaaata ttatctgaac tggactagtg aaaaatctag     1860

tatttgtatc ctggcaaata atactaattt ataatccaca gtaaagttca tcctttgact     1920

gtgctggaga attccagttg tatttgaaga ctgattttaa aacttttctg catttggtaa     1980

aggtatgtaa actttcctgt actcactgag taacagctaa tctttaatat aatattatac     2040

tgctatattt aaaaagctga ctacttgata taattactta atgtgatgct tgatataata     2100

attacttaat gtggccgggc acggtggctc acacctgtaa tcccagcact ttgggaggtc     2160

gaggtgggcg tatcacctga ggttgggagt tcgagaccag cctgaccaac gtggagaaac     2220

cccgtctcta ctaaaaatat gaaattagcc agggtggtgg tgcacacctg taatcccagc     2280

tacctgggag gctgcggcag gagaatcgct tgaacccagg tggcggaggt tgcggtgagc     2340

tgagatcacg ccattgcact ccagcctggg caacaagagc aaaactcagt ctcaaataat     2400

aataataaca acaacttaat gtgctgctgc ttttccataa ccaacatttt aaaaataaat     2460

gaaaaacagg aattgggaac tcctttaagg cttactttat tctttagatg cttaattatt     2520

gtgttaacta tttctgtagc ttagcttcca ctgtaaagtc atacagtaga caactcctgt     2580

ggacacgcag tagcatatcc ttaacattaa tttcagtcct cttgtccaca tttcccacaa     2640

ttaatagaac catcttctat ataaattgtg gtagtatctc tttatccttg atcttagaat     2700

agtcagtcca ctacaattac atgaacccca tttaaaaaac atatttaggg ccgggggcag     2760

tggctcacat ctgtaatcca agcactttgg gaggctgagg caggtggatc accagaggtt     2820

aggagttcga gactagcctg accaacatgg tgaagccccg tctctactaa gaatacaaaa     2880

aattagtcgg gcatggtagc aggcgcctgt agtcccagct actcaagagg ctgaggcagg     2940

agaatcgctt gaacctggga ggtggaggct gcagtgagcc gagactgcgc cattgcactc     3000

cagcctggca acaagagcaa aactctgtct caaacatatt ttggtctaaa tcattctgtg     3060

agaaaacaat cttctaatat gaaacacagt attctaattt ggtatatgca cactgttata     3120

tacctgtaat atttcagttt tctctccttc attctaacaa ttacaataat agaatcttag     3180

agttgcaagg gcctttagat gtaatcaatc ttagcctatt actagtacag cgtaaatgat     3240

ttagtacagt ataatgtatc acagttaaaa cagttaaatt ccatctctaa atgtcaccac     3300

ttcaggtgtg accaggtagc aaacactgac agaaaccctc gttcaattta gaactcttag     3360

ctgttgagat cacaaacacc tcatttattt ataataagta acctatctaa gttcaagcca     3420

atgctctttg gaaggcggag gagaccctat ctaatttgca tttaatcgta ggcaggtgtt     3480

taatgccatt taatgagtga aagcctggtg tgatgaattt agattgcctg ccagctacct     3540

accttagttc gtatacatcc ctgatccctc ttatactacc attactgtta cttatgattt     3600

ttatatataa atttttatcg acaaaaaaaa aaaaaaaaaa aaaaaa                    3646


<210>  906
<211>  468
<212>  PRT
<213>  Homo Sapiens

<400>  906

Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Thr Ser Thr Lys Thr Val Ile Arg Tyr Asn Gly Thr Val Thr Trp 
145                 150                 155                 160 


Thr Pro Pro Ala Asn Tyr Lys Ser Ser Cys Thr Ile Asp Val Thr Phe 
                165                 170                 175     


Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr 
            180                 185                 190         


Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln Asp Val Asp 
        195                 200                 205             


Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val Ser Ala Thr 
    210                 215                 220                 


Gly Ser Lys Gly Asn Arg Thr Asp Ser Cys Cys Trp Tyr Pro Tyr Val 
225                 230                 235                 240 


Thr Tyr Ser Phe Val Ile Lys Arg Leu Pro Leu Phe Tyr Thr Leu Phe 
                245                 250                 255     


Leu Ile Ile Pro Cys Ile Gly Leu Ser Phe Leu Thr Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asn Glu Gly Glu Lys Ile Cys Leu Cys Thr Ser Val 
        275                 280                 285             


Leu Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro 
    290                 295                 300                 


Ser Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Val Phe Thr 
305                 310                 315                 320 


Met Ile Phe Val Thr Leu Ser Ile Met Val Thr Val Phe Ala Ile Asn 
                325                 330                 335     


Ile His His Arg Ser Ser Ser Thr His Asn Ala Met Ala Pro Leu Val 
            340                 345                 350         


Arg Lys Ile Phe Leu His Thr Leu Pro Lys Leu Leu Cys Met Arg Ser 
        355                 360                 365             


His Val Asp Arg Tyr Phe Thr Gln Lys Glu Glu Thr Glu Ser Gly Ser 
    370                 375                 380                 


Gly Pro Lys Ser Ser Arg Asn Thr Leu Glu Ala Ala Leu Asp Ser Ile 
385                 390                 395                 400 


Arg Tyr Ile Thr Arg His Ile Met Lys Glu Asn Asp Val Arg Glu Val 
                405                 410                 415     


Val Glu Asp Trp Lys Phe Ile Ala Gln Val Leu Asp Arg Met Phe Leu 
            420                 425                 430         


Trp Thr Phe Leu Phe Val Ser Ile Val Gly Ser Leu Gly Leu Phe Val 
        435                 440                 445             


Pro Val Ile Tyr Lys Trp Ala Asn Ile Leu Ile Pro Val His Ile Gly 
    450                 455                 460                 


Asn Ala Asn Lys 
465             


<210>  907
<211>  8351
<212>  DNA
<213>  Homo Sapiens

<400>  907
ctgccgtcgt ggaagcagga tttccgcggt tgtgtaacgg cctgtcgcag gcgtgcaggg       60

acctggactc cgcctcgtcc ccggggctcg ggcagccgag ccatggcggg gaactgtggg      120

gcccgcggcg cgctgtcggc gcacacgctg ctgttcgacc tgccgcccgc gctgctcgga      180

gagctctgcg ctgttctgga cagctgcgac ggcgcgctgg gctggcgcgg cctggcagag      240

agactttcaa gcagctggct ggatgttcgt catattgaaa agtatgtaga ccaaggtaaa      300

agtggaacaa gagaattact ttggtcctgg gcacagaaaa acaagaccat cggtgacctt      360

ttacaggtcc tccaggagat gggacatcgt cgagctattc atttaattac aaactatgga      420

gcagtgttga gtccttcaga gaagagttat caggaaggtg gatttccaaa tatattattc      480

aaggaaacag ccaatgtcac cgtggataat gttcttattc ctgaacataa tgaaaaagga      540

atactgctta aatcttccat cagctttcaa aatatcatag aaggaactag aaatttccac      600

aaagacttcc taattggaga aggagagatt tttgaggtat acagagtgga gattcaaaac      660

ctaacatatg ctgtcaaatt atttaaacag gagaaaaaaa tgcagtgtaa gaagcattgg      720

aagaggtttt tatctgagct tgaagtttta ctactgtttc atcacccaaa catactagag      780

ttggctgcat attttacaga gactgagaag ttctgtctga tttatccata catgagaaat      840

ggaacacttt ttgacagatt gcagtgtgta ggtgacacgg ccccactccc ttggcacatt      900

cgaatcggta tattaatagg aatatccaaa gccattcact acctgcacaa cgttcaacca      960

tgctcggtca tctgtggcag tatatcaagt gcaaacatcc ttttggatga tcagtttcaa     1020

cccaaactaa ctgattttgc catggcacac ttccggtccc acctagaaca tcagagttgt     1080

accataaata tgaccagcag cagcagtaaa catctgtggt acatgccaga agagtacatc     1140

agacagggga aactttccat taaaacagat gtctacagct ttggaattgt aataatggaa     1200

gttctaacag gatgtagagt agtgttagat gatccaaaac atatccagct gcgggatctc     1260

cttagagaat tgatggagaa gagaggcctg gattcatgtc tctcatttct agataagaaa     1320

gtgcctccct gccctcggaa tttctctgcc aagctcttct gtttggcagg ccggtgtgct     1380

gcaacgcggg caaagttaag accatcaatg gatgaagttt taaatactct tgaaagtact     1440

caagccagct tgtattttgc tgaagatcct cccacatcac taaagtcctt caggtgtcct     1500

tctcctctat tcctggagaa tgtaccaagt attccagtgg aagatgatga aagccagaat     1560

aacaatttac taccttctga tgaaggcctg aggatagaca gaatgactca gaaaactcct     1620

tttgaatgca gccagtctga ggttatgttt ctgagcttgg acaaaaagcc agagagcaag     1680

agaaatgagg aagcttgcaa catgcccagt tcttcttgtg aagaaagttg gttcccaaag     1740

tatatagttc catcccagga cttaaggccc tataaggtaa atatagatcc ttcttcagaa     1800

gctccagggc attcttgcag gagcaggcca gtggagagca gctgttcctc caaattttcc     1860

tgggatgaat atgaacagta caaaaaagaa taaattctac cagaagataa agaaaaaagc     1920

aagtattgca taggcacctg agcataggta tgaccttggg aagacattgg ctccataagc     1980

aatgccaaga gaatgatcaa tagtgagttt gggtgatgca gataaacaat ctggataatt     2040

ccatttcttt tttcccaaac cctcaaacag agtgccttaa aaaattgttt tatcaggata     2100

attgtctcat gaccaaatcc acgctcaatt agagccattc aaaattcctt aagatcatgg     2160

gttctgactt cagccaaaca aaacaatcaa aacctaccaa aaagggactg gattgtaatg     2220

tcctctccat catcctcagt gtgagtcctc agagcctcca tctgccaaga acattcagtt     2280

ggattccatc gtttggttta gcttgcttgc acgggttgta ggaaatgtct aatttgtaaa     2340

tgttaataga tacctttgga aagaatcacc ttgttattct gattgacccc tcttgttttt     2400

tggttaatcc ctgactagcc tgcttgtctg aaaatgagcc aggttcaccc ttagctacgg     2460

catgctctgg gttgaaaggg gatttcttcc caagatctat cctaaactct taggacagtt     2520

tatcctgtat tgactattat tacagctttt taaaaacaga cttagtgacc tattatatct     2580

taaggagact atgtgaaatg tccatcaagt aatttttatt cctgagaaaa tggctggtca     2640

agggcctagg tcagcttttt gtttaatcta cacctttcaa ctctgggcct tcattcctgc     2700

tgtttcttgg atctccctct tttgaaatcc taccaatcat cagagctcta caaaacagcc     2760

acctcctgga agcttcccta atctctacaa ccagaagtac tccctttatc agtatttcca     2820

cagcaatttc tttgtatttc tattttatat ttatcacttt ctgaattata tcaaagctgc     2880

ttgtcttatc tctttttttt tttgagacgg agtctcgctc tgtcatccag gctggagtgc     2940

agtggcacaa tctcggctca ccgcaaggtc tgcctcccgg gttcacgcca ttctcctgcc     3000

tcagcctccc gagtaaaggt gggactacag gcgcccgcca ctacgcccgg ctaatttttt     3060

gtatttttag tagagacggg gtttcaccat gttaggcagg atggtctcga tctcctgacc     3120

tcatgatccg cctgcctggc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc     3180

cagccttcat ctcttttact aggttgtaaa ctccctatat tagttttcta ttgtttttgt     3240

aacacattat cacaaattta gtgacttaaa gtaacataaa ttaattattt tgcagttctg     3300

gaggtcagaa ttccttagca ttctttctgg aggctgttgg ggagaactca ctgccttgcc     3360

ttttccagct tctagaggcc acctgccttc tttggctcat ggcctcttcc tccgtcttca     3420

aagccagcaa cgtgacattt cagatctccc tctctctgtc tgtctcaccg catctcttca     3480

ctaccctctt cctctcattc tggcccttct gcatgtcttt tataaagacc tttgtgattt     3540

cactgggccc actcatataa gccaggaaaa tctctgtgtc tcagatcctt aatttaatta     3600

cacctgcaaa gtccgttttc tcgtgtaaag taacatattc acaggtttct ggaattggga     3660

cgtggacatc ttcgggggac cattactctg tctgtcatac tccctgagtg tgtaagggcc     3720

atctcttcag agcctaatgt gtcatcctac acagagcagg tgtttcctta taaattaagt     3780

tgaattaaat tacccctatg aagccacata atcaataatt cagctataat aaacattgcc     3840

gaataaatta acaaagggag gataatgact ccttatgatg atggatagaa acactgaaga     3900

aaaccatttt cagaggattt actgaatttt cctctccaag gagcttgtaa tagaagggta     3960

aacctctagt ttcttgtcca gcagaggaat aggctcatgt cttttgtttt attttatttt     4020

tttggtgagt cagtatggtt gggttaatca tattcacatt agattccatg ttgaagaaca     4080

actaatcaaa gaagaaaatc atcaggaatc agggtgagat taacagacca aggtcagaaa     4140

catggagtta caattttcca aaaaagcacg aagtgagatt aaaaccacag taagtcttag     4200

tctgactgac aggctttata caggccctcg gtaagcagtt gggagaaccc atgcccacca     4260

ctgctctgta cggtatctgg ctgctcagag ctctctgatt cacaaaagag atcatcaaga     4320

attgactctg tgttaaactg tttttcactt agaatatgga cccccaccaa tacattcaat     4380

gaagggtcat taaggaagct ctgattaaca ccaggcccat gcagttactc cgcacatata     4440

atctgtgggt attatgttga tttgaacttg cttagctgac ttaaagcagg gtttctcaaa     4500

ctgtagtatg catcagaatg acttggaaag ctggttaaaa acgcagattg ctgggtccac     4560

ccagcttctg atgcaatagg tctggggtta gaaattttgc tttctaatga gttcccaggt     4620

gatgctgatg ccaatgatgt gaagcccgct cttcacatcc gtgaaaatcg ctgccttaag     4680

gtgctcttaa attgttatag attggtagat cctacctttc catcactggt atgttttttg     4740

agaaaaggat cctttctttt cattctgtta tattcatcct attacatagg atgttggtta     4800

gcacagagtg ggagctctag aaagattgtt gaccaatcat cttattgact agaccatctt     4860

tctagagtat aactattttg gacacctcaa agatgaagtc agataagctg gcagtgacct     4920

gattaacgtt gtggtaagca gatgccactg tggctgggaa gtaccaaatc ttctgttgag     4980

tgattcagtc ttcctgacta gatttgcctt ctagtgggtg tattaataag cgttagttga     5040

tatgaattaa atgttgcaac tttctatggg taataagagg atacctttat agtttcatga     5100

tgtggagacc aagatacata agaaagcaag aatgagtctc cgggtgttcc ctctgatcag     5160

caaacatgaa ttcataattt catttactct catttttgta atgcactctg agcaatcctc     5220

caggcagatc ctatttacta agcttcaggc ttttgtccca ttttataatg cccaaacaca     5280

tggagaaaac attttgttgt ttttaaaaac aggtatggga tttctgatat aatcaatttt     5340

attgacttct tgggagttgt aatgatctgt gactcactgc ataatattgt agttttatag     5400

ggtggcacat caccctgtgt aaaacaactt taatgacctg aggactgatg agtacaggaa     5460

gtgaggttta tcatgagtag catttattaa gcatctgcta gaatcaaagc actgcattag     5520

ctactaaggt acaaagtaag acacagttta ataaggaaga cagggcatct acccaagtca     5580

acagttcagt gacatctgtt atttgaacca cacaccaatg caaccgaagt aaatgctgaa     5640

agggtgagaa gaaggaatag attactatgc atttttgaga ggatgaagaa ggcttcttgg     5700

agaaggtttc tgaaaagaga tacggaatta agagaaatag aaaagagcac tgacgaagca     5760

ctcaggatgg ctattcaagg aattggggat ccacagcagc tgtgcacaac catccctaat     5820

gccagaaaaa tggggtaagg gtgaagggaa ctgggtctag agctttgcat gtttttttct     5880

ggttaaccct tagagtcacc ctgaaggtgt ggatcccatc ttataataag gtgaggacac     5940

tgagtcagga aactaacttg ctaaaatcaa gtcctcccag tcctcccatc aggtccttcc     6000

agatctggag gagccaggat ttgaactcac atttgtctga cttcaaaatc catgcttttt     6060

cttgtgttcc aaattgcaca atggagtcac tgccagttca agctcctatg aaaagggatg     6120

gatgtgaaaa gtcatttgtt gattccacag atttttagta ggtaccatgt ctcctgcctt     6180

tatcactatc ctactcctct gctacaactt ctctgctaca ggcacccact gcagttactt     6240

gatatgagtt aaatgaatcc atccatccaa acttccattc attgaataaa tacttagcaa     6300

tggcttcctt tgtatcaggc actattctag gagctggggc tacagtgcag atggaaacca     6360

gcaaagctca ctgccctcat ggagcttata tgtaagtgaa taaatctcag ggtggttctc     6420

ctgtcatagg tcctggctcc tctgccagct cttccaaatg ggttcagaga ggttttctcc     6480

ttgtcctgtt gtgtaactga taatcccatg gtggacctca ctttgctatt catatgcact     6540

aagtagttta tggtgtgctt tgtggctggc aattgtgaca gattctattc ttctattggt     6600

atgtggtttc tttggggcat ttgtttggat actgatggca tcttccgggg gtctgaggca     6660

cctacacaaa cctcaggtca ctatcacgtg atactggagt tgcctgttaa attatatttc     6720

ttcttccaca aaactgcagg ttccctgagg gaaaggtcta tgtcctgctc atttttggat     6780

ccctaatggc tggcacagta cctggtgcat aatatggttc aacaaatatt tgtaaaatga     6840

atgaatcaaa tagtccttca aagcatcttc agaatcaaga ttgtcatcta gattgcaccc     6900

gaagtttatc tttctagtat tcagaatata atcaatcatt gcttaaatta ttccatttca     6960

tcattcttga ataaaagcta ctaattttaa atactaatat ctgagatatc ttcgaaaaga     7020

agattagtcg ttgtatgtgt tgcttataaa ttttctctat ggtggaaaat attcccaaac     7080

catgtctaag caatgaaaaa ccagtgttct ggcaggaaat aaactgatgt ttgttgtgtt     7140

ttgtatctgt cttcccgttc caaatcattt atatatactt gatggtctgt gggcttgact     7200

tgcaagtatt ttcctgggag acatttttat tcaaaagacc tgtattgcct gccaaacctt     7260

catttaagag actcattatg gatgtcatct gcatcattgc aaacttttct ggtcgtctct     7320

ataaatagca agataatatt tacagagttt tacattggct cttgaatttt aaaatattct     7380

tatagacaaa cattaattgg aatggggggt aaggaggtag gaatggctta cttgcggaaa     7440

tgcaggctca ttgttgtgtc tagtaggtgc taggtgcatt cacacatctc ttaagcttta     7500

aacaacctat tgagccggtt tccatttcct tgatctatta gatttaaaaa aatgaagcat     7560

aaaggagttg gctcttgccc taagtcatac tactgatgga atgagaatac aaaccaaaaa     7620

cactttattc aagtccagga aatatctgcc ttgaaaaaga ataacttaaa aattaaaagt     7680

gtcctctatt tgaacatgaa aacagctaat aaagatgtgt tattttattt tattattatt     7740

aattttgtcc tcccatattg gcaaagataa agcaattgac aaaaatggaa ttcttgttca     7800

atactggcag gagtgaaaat tggtagaacc tttctagaag gcaatttggc aacatgtatg     7860

aaaacctaaa tgttgataca cctttaccca gcagtttgtt taggaattta tcctaatgaa     7920

taaaagttgt ccaagtcttc aaacatgagc ccaaaggtat atttcatgat gtttatgata     7980

ttaaaacatt ggaaacaact gaaacatcct tcagtaaaag atggattaaa taaattccat     8040

gcagttgtca tttaaaaata tttagatata tgtttattgc tatggatata tgttcccaaa     8100

atattattga atcaaaaagt agactacagg atatatgttg aatatgagct catttataac     8160

attgaatatt ttaagataat gtatgtttca tagagagatc ttcaccaaat gttaaggatt     8220

tttttttctg ggctgtggta tttgggtgat ctttacattc ttcagactca tgtgtgtttg     8280

aaacttttta taatgaacat atatcatttt tattagaaaa gaataaagtt tttgaaaaaa     8340

aaaaaaaaaa a                                                          8351


<210>  908
<211>  596
<212>  PRT
<213>  Homo Sapiens

<400>  908

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Ala Glu Arg Leu 
        35                  40                  45              


Ser Ser Ser Trp Leu Asp Val Arg His Ile Glu Lys Tyr Val Asp Gln 
    50                  55                  60                  


Gly Lys Ser Gly Thr Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys Asn 
65                  70                  75                  80  


Lys Thr Ile Gly Asp Leu Leu Gln Val Leu Gln Glu Met Gly His Arg 
                85                  90                  95      


Arg Ala Ile His Leu Ile Thr Asn Tyr Gly Ala Val Leu Ser Pro Ser 
            100                 105                 110         


Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu Phe Lys Glu 
        115                 120                 125             


Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu His Asn Glu 
    130                 135                 140                 


Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn Ile Ile Glu 
145                 150                 155                 160 


Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu Gly Glu Ile 
                165                 170                 175     


Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr Ala Val Lys 
            180                 185                 190         


Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His Trp Lys Arg 
        195                 200                 205             


Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His Pro Asn Ile 
    210                 215                 220                 


Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe Cys Leu Ile 
225                 230                 235                 240 


Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu Gln Cys Val 
                245                 250                 255     


Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly Ile Leu Ile 
            260                 265                 270         


Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln Pro Cys Ser 
        275                 280                 285             


Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu Asp Asp Gln 
    290                 295                 300                 


Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe Arg Ser His 
305                 310                 315                 320 


Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser Ser Ser Lys 
                325                 330                 335     


His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly Lys Leu Ser 
            340                 345                 350         


Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met Glu Val Leu 
        355                 360                 365             


Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile Gln Leu Arg 
    370                 375                 380                 


Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp Ser Cys Leu 
385                 390                 395                 400 


Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn Phe Ser Ala 
                405                 410                 415     


Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg Ala Lys Leu 
            420                 425                 430         


Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser Thr Gln Ala 
        435                 440                 445             


Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys Ser Phe Arg 
    450                 455                 460                 


Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile Pro Val Glu 
465                 470                 475                 480 


Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp Glu Gly Leu 
                485                 490                 495     


Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys Ser Gln Ser 
            500                 505                 510         


Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser Lys Arg Asn 
        515                 520                 525             


Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu Ser Trp Phe 
    530                 535                 540                 


Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr Lys Val Asn 
545                 550                 555                 560 


Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg Ser Arg Pro 
                565                 570                 575     


Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu Tyr Glu Gln 
            580                 585                 590         


Tyr Lys Lys Glu 
        595     


<210>  909
<211>  3936
<212>  DNA
<213>  Homo Sapiens

<400>  909
agtcaccttt tcgtgggttc ctctcacagc gctcggccgt cgagcggggt cgctaacccg       60

cactctcttc ggacctacga catcgcggct tctctggcgt tggccagtca gccacaggga      120

actagtaaaa aaagaaaaag aaaaaataaa gtgaaagagg cgtgttgtct agtttcaaag      180

gagaggagag aagagactga gtcgccctgt gttgcccagg ctggtcttga actcctaggc      240

tcaagagatc ctcctgcctc agcctcccaa agtgctggga ttacaggcaa ctctggtagc      300

tctccttgtc tggttgtttt gaagaaagaa gagtagaaga aaaagttgag taaatcatgt      360

cggagttact ggacctttct tttctgtctg aggaggaaaa ggatttgatt ctcagtgttc      420

tacagcgaga tgaagaggtc cggaaagcag atgagaaaag gattaggcga ctaaagaatg      480

agttactgga gataaaaagg aaaggggcca agaggggcag ccaacactac agtgatcgga      540

cctgtgcccg gtgccaggag agcctgggcc gtttgagtcc caaaaccaat acttgtcggg      600

gttgtaatca cctggtgtgt cgggactgcc gcatacagga aagcaatggt acctggaggt      660

gcaaggtgtg cgccaaggaa atagagttga agaaagcaac tggggactgg ttttatgacc      720

agaaagtgaa tcgctttgct taccgcacag gtagtgagat aatcaggatg tccctgcgcc      780

acaaacctgc agtgagtaaa agagagacag tgggacagtc cctccttcat cagacacaga      840

tgggtgacat ctggccagga agaaagatca ttcaggagcg gcagaaggag cccagtgtgc      900

tatttgaagt gccaaagctg aaaagtggaa agagtgcatt ggaagctgag agtgagagtc      960

tggatagctt cacagctgac tcggatagca cctccaggag agactctctg gataaatctg     1020

gcctctttcc agaatggaag aagatgtctg ctcccaaatc tcaagtagaa aaggaaactc     1080

agcctggagg tcaaaatgtg gtatttgtgg atgagggtga gatgatattt aagaagaaca     1140

ccagaaaaat cctcaggcct tcagagtaca ctaaatctgt gatagatctt cgcccagaag     1200

atgtggtaca tgaaagtggc tccttgggag acagaagcaa atccgtccca ggcctcaatg     1260

tggatatgga agaggaagaa gaagaagaag acattgacca cctagtgaag ttacatcgcc     1320

agaagctagc cagaagcagc atgcaaagtg gctcctccat gagtacgatc ggcagcatga     1380

tgagcatcta cagtgaagct ggtgatttcg ggaacatctt tgtgactggc aggattgcct     1440

tttccctgaa gtatgagcag caaacccaga gtctggttgt ccatgtgaag gagtgccatc     1500

agctggccta tgctgatgaa gccaagaagc gctctaaccc atatgtgaag acttaccttc     1560

tgcctgacaa gtcccgccaa ggaaaaagaa aaaccagcat caagcgggac actattaatc     1620

cactatatga tgagacgctg aggtatgaga tcccagaatc tctcctggcc cagaggaccc     1680

tgcagttctc agtttggcat catggtcgtt ttggcagaaa cactttcctt ggagaggcag     1740

agatccagat ggattcctgg aagcttgata agaaactgga tcattgcctc cctttacatg     1800

gaaagatcag tgctgagtcc ccgactggct tgccatcaca caaaggcgag ttggtggttt     1860

cattgaaata catcccagcc tccaaaaccc ctgttggagg tgaccggaaa aagagtaaag     1920

gtggggaagg gggagagctc caggtgtgga tcaaagaagc caagaacttg acggctgcca     1980

aagcaggagg gacttcagac agctttgtca agggatacct ccttcccatg aggaacaagg     2040

ccagtaaacg taaaactcct gtgatgaaga agaccctgaa tcctcactac aaccatacat     2100

ttgtctacaa tggtgtgagg ctggaagatc tacagcatat gtgcctggaa ctgactgtgt     2160

gggaccggga gcccctggcc agcaatgact tcctgggagg ggtcaggctg ggtgttggca     2220

ctgggatcag taatggggaa gtggtggact ggatggactc gactggggaa gaagtgagcc     2280

tgtggcagaa gatgcgacag tacccagggt cttgggcaga agggactctg cagctccgtt     2340

cctcaatggc caagcagaag ctgggtttat gagtccctgt cctcttctgc aggtccagcc     2400

ctggcgaggg caggtcagag gaagtgaaga aatcaagagc aaagatttat aatttaatgt     2460

gtatgtgtgt atgtgtgtat gtgtgtgtgt gtgtgtgtgt gtgtatgtgt acaaacatgt     2520

attttctgca aatctcatta tgctggctag agtgatgcag acttgttctt ctttttaaag     2580

cagtctcaag aataagcatt tctttaaaat gtttctgtgt ataatctagt ttattttcag     2640

agtccatttt ttcttatgtc tttataaggt tcacttaact taaaaacagc ttttaaaaca     2700

actttttatc ttctgtcttg ctatcattgt tcctacttcc ctaggaagcc ctggctacct     2760

ttcgcattag gaccagtctg ggttttaagg ctctgggaag cagggttggt tagtaaagac     2820

aggaatgttg gggagaggtg agtagttcct tcctctttct cctctccaat ttatgctttt     2880

aacttatttt ctacctggat aaacttctgg aacttggctt ttaaatttaa cttttctagt     2940

ttttaagcag tttccacctt gctttggtct aatgcttttc tttgaaatgc taacagaatt     3000

cccaagcttt ttccagttct agatatcttt actagacctt tgggggactc ttataatgga     3060

gctgcttttg aaaagcactt taattagata atgtattttg actaaatcac gaggatgccc     3120

agtgagagct tctagctgat ctcagaggac cagagtgact gagggtaaag tgtctcacag     3180

cccatgctga attttctgca ttttaaactg atactgcagt cattggagag agagctcctc     3240

atttctcgaa tgaaagatga gatatattca tcctcatgta ccacatctgt cttagtgttt     3300

gcgtctgggg tgtgttatca aacagagcat ggtctacatc ccactgtgtc aaccagaaga     3360

gccaagtgtt atctcaattg gcccagtgtt tctccaggct ggggactgtt aagggctcta     3420

agggaatgta gacagagtct ccctgttatt ctgacttcct gcttgatgag ctttcagttc     3480

ctgtttttgc tattgtttcc taaatttgac ctacatatta catgggtgta gtgtgttgag     3540

gcttttcaaa gaagggtcta gtgagctaag tttcatcttc tggtactcat tgatcaaact     3600

gacctttcta ttctcataag cgtttctacc caaagttgtg tgtggaagga gtgtatagca     3660

gagaggaaat ccctttcaac agagtcagct gctaactgat ttcctataag cacactggat     3720

taagggcagc cacagtggtt tctactgtat gtatgaaccg aatggaggaa tgttttcaaa     3780

gattgatttg gtgtggattg caattgtaat ggaaggcata acttgggatc ccgggctgta     3840

acttgctctt ttgtttccca cccccctgac atgtatgtgt gctttaataa agctttctca     3900

cttgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                               3936


<210>  910
<211>  671
<212>  PRT
<213>  Homo Sapiens

<400>  910

Met Ser Glu Leu Leu Asp Leu Ser Phe Leu Ser Glu Glu Glu Lys Asp 
1               5                   10                  15      


Leu Ile Leu Ser Val Leu Gln Arg Asp Glu Glu Val Arg Lys Ala Asp 
            20                  25                  30          


Glu Lys Arg Ile Arg Arg Leu Lys Asn Glu Leu Leu Glu Ile Lys Arg 
        35                  40                  45              


Lys Gly Ala Lys Arg Gly Ser Gln His Tyr Ser Asp Arg Thr Cys Ala 
    50                  55                  60                  


Arg Cys Gln Glu Ser Leu Gly Arg Leu Ser Pro Lys Thr Asn Thr Cys 
65                  70                  75                  80  


Arg Gly Cys Asn His Leu Val Cys Arg Asp Cys Arg Ile Gln Glu Ser 
                85                  90                  95      


Asn Gly Thr Trp Arg Cys Lys Val Cys Ala Lys Glu Ile Glu Leu Lys 
            100                 105                 110         


Lys Ala Thr Gly Asp Trp Phe Tyr Asp Gln Lys Val Asn Arg Phe Ala 
        115                 120                 125             


Tyr Arg Thr Gly Ser Glu Ile Ile Arg Met Ser Leu Arg His Lys Pro 
    130                 135                 140                 


Ala Val Ser Lys Arg Glu Thr Val Gly Gln Ser Leu Leu His Gln Thr 
145                 150                 155                 160 


Gln Met Gly Asp Ile Trp Pro Gly Arg Lys Ile Ile Gln Glu Arg Gln 
                165                 170                 175     


Lys Glu Pro Ser Val Leu Phe Glu Val Pro Lys Leu Lys Ser Gly Lys 
            180                 185                 190         


Ser Ala Leu Glu Ala Glu Ser Glu Ser Leu Asp Ser Phe Thr Ala Asp 
        195                 200                 205             


Ser Asp Ser Thr Ser Arg Arg Asp Ser Leu Asp Lys Ser Gly Leu Phe 
    210                 215                 220                 


Pro Glu Trp Lys Lys Met Ser Ala Pro Lys Ser Gln Val Glu Lys Glu 
225                 230                 235                 240 


Thr Gln Pro Gly Gly Gln Asn Val Val Phe Val Asp Glu Gly Glu Met 
                245                 250                 255     


Ile Phe Lys Lys Asn Thr Arg Lys Ile Leu Arg Pro Ser Glu Tyr Thr 
            260                 265                 270         


Lys Ser Val Ile Asp Leu Arg Pro Glu Asp Val Val His Glu Ser Gly 
        275                 280                 285             


Ser Leu Gly Asp Arg Ser Lys Ser Val Pro Gly Leu Asn Val Asp Met 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Asp Ile Asp His Leu Val Lys Leu His 
305                 310                 315                 320 


Arg Gln Lys Leu Ala Arg Ser Ser Met Gln Ser Gly Ser Ser Met Ser 
                325                 330                 335     


Thr Ile Gly Ser Met Met Ser Ile Tyr Ser Glu Ala Gly Asp Phe Gly 
            340                 345                 350         


Asn Ile Phe Val Thr Gly Arg Ile Ala Phe Ser Leu Lys Tyr Glu Gln 
        355                 360                 365             


Gln Thr Gln Ser Leu Val Val His Val Lys Glu Cys His Gln Leu Ala 
    370                 375                 380                 


Tyr Ala Asp Glu Ala Lys Lys Arg Ser Asn Pro Tyr Val Lys Thr Tyr 
385                 390                 395                 400 


Leu Leu Pro Asp Lys Ser Arg Gln Gly Lys Arg Lys Thr Ser Ile Lys 
                405                 410                 415     


Arg Asp Thr Ile Asn Pro Leu Tyr Asp Glu Thr Leu Arg Tyr Glu Ile 
            420                 425                 430         


Pro Glu Ser Leu Leu Ala Gln Arg Thr Leu Gln Phe Ser Val Trp His 
        435                 440                 445             


His Gly Arg Phe Gly Arg Asn Thr Phe Leu Gly Glu Ala Glu Ile Gln 
    450                 455                 460                 


Met Asp Ser Trp Lys Leu Asp Lys Lys Leu Asp His Cys Leu Pro Leu 
465                 470                 475                 480 


His Gly Lys Ile Ser Ala Glu Ser Pro Thr Gly Leu Pro Ser His Lys 
                485                 490                 495     


Gly Glu Leu Val Val Ser Leu Lys Tyr Ile Pro Ala Ser Lys Thr Pro 
            500                 505                 510         


Val Gly Gly Asp Arg Lys Lys Ser Lys Gly Gly Glu Gly Gly Glu Leu 
        515                 520                 525             


Gln Val Trp Ile Lys Glu Ala Lys Asn Leu Thr Ala Ala Lys Ala Gly 
    530                 535                 540                 


Gly Thr Ser Asp Ser Phe Val Lys Gly Tyr Leu Leu Pro Met Arg Asn 
545                 550                 555                 560 


Lys Ala Ser Lys Arg Lys Thr Pro Val Met Lys Lys Thr Leu Asn Pro 
                565                 570                 575     


His Tyr Asn His Thr Phe Val Tyr Asn Gly Val Arg Leu Glu Asp Leu 
            580                 585                 590         


Gln His Met Cys Leu Glu Leu Thr Val Trp Asp Arg Glu Pro Leu Ala 
        595                 600                 605             


Ser Asn Asp Phe Leu Gly Gly Val Arg Leu Gly Val Gly Thr Gly Ile 
    610                 615                 620                 


Ser Asn Gly Glu Val Val Asp Trp Met Asp Ser Thr Gly Glu Glu Val 
625                 630                 635                 640 


Ser Leu Trp Gln Lys Met Arg Gln Tyr Pro Gly Ser Trp Ala Glu Gly 
                645                 650                 655     


Thr Leu Gln Leu Arg Ser Ser Met Ala Lys Gln Lys Leu Gly Leu 
            660                 665                 670     


<210>  911
<211>  49
<212>  RNA
<213>  Homo Sapiens

<400>  911
ccaggagaaa acgccagcgc acgacagaag gaagaaaagg gcgaggaga                   49


<210>  912
<211>  4109
<212>  DNA
<213>  Homo Sapiens

<400>  912
cgggccgggg cggcgcgagc ggctggagca acgggccccg cggcagctgc gggcgacgcg       60

gtcgatggac atgggcaccc agggatcggg gcgcaagcgg ctccccaacc gggagcggct      120

cacggcggag gacgacgcgc tcaaccagat cgcgcgggag gcggaagccc ggctcgctgc      180

aaaacgggcg gcccgcgcgg aggctcgcga gatccgcatg aaggagctgg agcggcagca      240

gaaggagatc tatcaggtcc aaaagaaata ttatgggctg gatacaaaat ggggtgacat      300

cgagcagtgg atggaagaca gtgagcgcta ctctcgtaga tccagaagaa acacatcggc      360

ttctgatgaa gacgagcgca tgtcagtggg tagtcgtgga agcctgaggt cgcagcctga      420

cttggagtat gggggtcctt acgcctggac aaatggttat gatggagaat tgtatggatc      480

acagtccctg aatagaagat ctggcaggcc ctcctgtctg tacagcgctg cccggccttc      540

ggggagttac cgggcgtctg tgttggatga aggcagcttc ggtgggaccc gacggggcag      600

cacctccggc tcccgtgctc cctcggagta cagcggccac ctcaactcca gctcccgcgc      660

ctcctccagg gccagctcgg cccgggccag ccctgtggta gaagagagac cagaaaaaga      720

ttttactgag aaggggtctc gtaacatgcc gggcctgtct gcagccacgc tggcctctct      780

gggtgggact tcctctcgga gaggcagcgg agacacctcc atctccatcg acaccgaggc      840

atccatcagg gaaatcaagg aactcaatga gttaaaggac cagattcagg atgtagaagg      900

caaatacatg cagggattga aagagatgaa ggactctcta gcagaagttg aagagaaata      960

taagaaggct atggtttcca atgctcagct agacaatgaa aagacaaact tcatgtacca     1020

ggttgatacc ctaaaagata tgttgctgga gcttgaagaa cagctggctg aatctaggcg     1080

gcagtacgaa gagaaaaaca aagaatttga aagggaaaaa cacgcccaca gtatactgca     1140

atttcagttt gctgaagtca aggaggccct gaagcaaaga gaggaaatgc tcgaggaaat     1200

ccgacagcta cagcagaaac aggcgagttc tatcagggag atttctgatc ttcaggaaac     1260

aatagagtgg aaagacaaaa agataggggc attagagagg cagaaagagt tctttgattc     1320

cgtaaggagt gaacgggatg atcttagaga agaagtagtc atgctgaaag aggaattaaa     1380

gaaacatgga ataatcctaa attcagaaat agctaccaat ggagagactt ccgacaccct     1440

caataatgtt ggataccaag gtcctaccaa gatgacaaaa gaagagttaa atgccctcaa     1500

gtcgacaggg gatgggaccc tagatattag gttgaaaaag ctggttgatg aacgggaatg     1560

cttattggaa cagattaaga aactcaaagg gcagctggag gagagacaga agattggcaa     1620

actagacaat cttcgatctg aagatgatgt cttggaaaac gggacagaca tgcatgtaat     1680

ggacctacaa agggatgcca acagacagat cagcgacctc aaatttaaac ttgcaaaatc     1740

tgagcaagag ataactgcat tagaacaaaa tgtaataagg ttagagagtc aagtatcacg     1800

ttacaaatca gcggctgaaa atgcagaaaa aatagaagat gaacttaagg cagaaaaacg     1860

gaaactccaa agagagctcc gctctgcatt ggataaaaca gaagagctcg aggtgagcaa     1920

cggccactta gtgaagcgtc tggaaaaaat gaaagcaaat cggagtgcac tcttgtccca     1980

gcagtaaatt ccagctctga tcaggcaact ggttggtgac tggagagcat tgtttcatag     2040

gcttttctct gtcctatctg ggagcgctgc ttcttcccct gccttccgag agacgaagac     2100

cgtggcgagc ttggcgctta ggggctcccg tgccatggct caccccaggg agccccagca     2160

gccaccaggt gcctctgtct gcagacccct ggcccgggct ggcgccgacg ctcagaacct     2220

gcaggtactt cataagcaca caggggcctc gagggagctc tgtgtctgac cgcacagcag     2280

cctctgaatg ccgctggaag tgatgatcaa agtaaagatt cagttgggac ttgagttttt     2340

tttttttttc atgtgtcttg ctgaagatta aggggaaatg ttacagtgtt gggacttcct     2400

ttcatggcag aatctacaat ttgagcgact tcagtagtat ctcttagtct acgcttttca     2460

tacacaaaac actgtggaac cacaagccat taccaagcaa aactctttca ctggaaacaa     2520

gggggcagtc tagaagtaaa agtgacctta agaagactct ttacaggcaa caaatgaagc     2580

ttttctaagg gatttttgca tcagttcagt cataagaata cttttttcca gggtaattag     2640

gcaatagctt cactgaaaat gacagctttt cattgcatta tttaatcctt atatttggaa     2700

ttgaagtcgt taacttcttt taaagaatgt actattagaa aaattaaaaa tgaaatgttg     2760

agagacttca gcaatgtggt tctaattttt ttccactgag aaagaagatc tttaatttca     2820

tattaatggt tctgtatatt ttgggtcatc tttttatttt ttaagaatat caagtcaatt     2880

catttttctt tccctattta aaaaaaaagg tgttttcaca gaatgagtgc acttaaaaag     2940

tgaagtgaag gaggaggtaa cagtagagac gatggcaata tcatcaagga caaaagtaaa     3000

aacgtttagc tacctgctga tttttagtga ctgttcatat atgttgtatt tcaagtatgg     3060

ctggtgaagc cagtcagctt ttcgggacgt tagcaagtgg aaactgagtc agtatcatcc     3120

aaaaccatat ctagtcttaa cacatggaga atgctggagt gagggttgtg agttcagggt     3180

atataatcaa gaaaacactc ccagcataat gctaggggtc accagtgtcc atcccccaga     3240

actgtatgga tctaggatat acacagctgc gttgcattaa gaaagagatg aaatctctat     3300

taaaatacac aagatttttg tatctccttg tgcagaggat atttgccact gcccattggg     3360

aagcagacaa gttatagggg gctgggggcc aacactggca agtaggaaac cacgggtcgg     3420

acaggtgagc aaaatgtgct ggcaggtggg caccactggg agacccacac tgcacacccg     3480

ggcaccgtat gaacaggaaa gaggaaggaa gctggacgaa gcccctcagg gaccctgtgc     3540

tgaccatgct gggcccaccg gcaaaaggga gatattcagt tccttgtctc atccttaagg     3600

tttcttccac aacatctgaa tacaagcatg tttaactggg aaaatgtcta tgtcatgcgt     3660

gaataacacc agcagcaaac actcacacat cacgcagaca cggccggcag catgctgacg     3720

cttttaggta tttttcactc atgcaatttt cacatatttt cactcatttc atttgcacgg     3780

aaattctatg aggtagatgc tgttatcaaa tccacattac agatgaggga cccagggtcc     3840

aggaaggtga actggcagaa gtctcccagc tggtagaaca gggctgcaag gcatcgattc     3900

ccaggtgtct cacagccctg agaagatggc gttttcccta tcagtggctc tgaggaagtc     3960

aagccttcag tctctacctc tcccaccaat tcttttggaa acagcaaacc aatgttacac     4020

acacttccta atccagagga agctagaaca cgatttttaa atttatttag taaaataaaa     4080

ctttttttgc agatgtaacg aaaaaaaaa                                       4109


<210>  913
<211>  640
<212>  PRT
<213>  Homo Sapiens

<400>  913

Met Asp Met Gly Thr Gln Gly Ser Gly Arg Lys Arg Leu Pro Asn Arg 
1               5                   10                  15      


Glu Arg Leu Thr Ala Glu Asp Asp Ala Leu Asn Gln Ile Ala Arg Glu 
            20                  25                  30          


Ala Glu Ala Arg Leu Ala Ala Lys Arg Ala Ala Arg Ala Glu Ala Arg 
        35                  40                  45              


Glu Ile Arg Met Lys Glu Leu Glu Arg Gln Gln Lys Glu Ile Tyr Gln 
    50                  55                  60                  


Val Gln Lys Lys Tyr Tyr Gly Leu Asp Thr Lys Trp Gly Asp Ile Glu 
65                  70                  75                  80  


Gln Trp Met Glu Asp Ser Glu Arg Tyr Ser Arg Arg Ser Arg Arg Asn 
                85                  90                  95      


Thr Ser Ala Ser Asp Glu Asp Glu Arg Met Ser Val Gly Ser Arg Gly 
            100                 105                 110         


Ser Leu Arg Ser Gln Pro Asp Leu Glu Tyr Gly Gly Pro Tyr Ala Trp 
        115                 120                 125             


Thr Asn Gly Tyr Asp Gly Glu Leu Tyr Gly Ser Gln Ser Leu Asn Arg 
    130                 135                 140                 


Arg Ser Gly Arg Pro Ser Cys Leu Tyr Ser Ala Ala Arg Pro Ser Gly 
145                 150                 155                 160 


Ser Tyr Arg Ala Ser Val Leu Asp Glu Gly Ser Phe Gly Gly Thr Arg 
                165                 170                 175     


Arg Gly Ser Thr Ser Gly Ser Arg Ala Pro Ser Glu Tyr Ser Gly His 
            180                 185                 190         


Leu Asn Ser Ser Ser Arg Ala Ser Ser Arg Ala Ser Ser Ala Arg Ala 
        195                 200                 205             


Ser Pro Val Val Glu Glu Arg Pro Glu Lys Asp Phe Thr Glu Lys Gly 
    210                 215                 220                 


Ser Arg Asn Met Pro Gly Leu Ser Ala Ala Thr Leu Ala Ser Leu Gly 
225                 230                 235                 240 


Gly Thr Ser Ser Arg Arg Gly Ser Gly Asp Thr Ser Ile Ser Ile Asp 
                245                 250                 255     


Thr Glu Ala Ser Ile Arg Glu Ile Lys Glu Leu Asn Glu Leu Lys Asp 
            260                 265                 270         


Gln Ile Gln Asp Val Glu Gly Lys Tyr Met Gln Gly Leu Lys Glu Met 
        275                 280                 285             


Lys Asp Ser Leu Ala Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
    290                 295                 300                 


Ser Asn Ala Gln Leu Asp Asn Glu Lys Thr Asn Phe Met Tyr Gln Val 
305                 310                 315                 320 


Asp Thr Leu Lys Asp Met Leu Leu Glu Leu Glu Glu Gln Leu Ala Glu 
                325                 330                 335     


Ser Arg Arg Gln Tyr Glu Glu Lys Asn Lys Glu Phe Glu Arg Glu Lys 
            340                 345                 350         


His Ala His Ser Ile Leu Gln Phe Gln Phe Ala Glu Val Lys Glu Ala 
        355                 360                 365             


Leu Lys Gln Arg Glu Glu Met Leu Glu Glu Ile Arg Gln Leu Gln Gln 
    370                 375                 380                 


Lys Gln Ala Ser Ser Ile Arg Glu Ile Ser Asp Leu Gln Glu Thr Ile 
385                 390                 395                 400 


Glu Trp Lys Asp Lys Lys Ile Gly Ala Leu Glu Arg Gln Lys Glu Phe 
                405                 410                 415     


Phe Asp Ser Val Arg Ser Glu Arg Asp Asp Leu Arg Glu Glu Val Val 
            420                 425                 430         


Met Leu Lys Glu Glu Leu Lys Lys His Gly Ile Ile Leu Asn Ser Glu 
        435                 440                 445             


Ile Ala Thr Asn Gly Glu Thr Ser Asp Thr Leu Asn Asn Val Gly Tyr 
    450                 455                 460                 


Gln Gly Pro Thr Lys Met Thr Lys Glu Glu Leu Asn Ala Leu Lys Ser 
465                 470                 475                 480 


Thr Gly Asp Gly Thr Leu Asp Ile Arg Leu Lys Lys Leu Val Asp Glu 
                485                 490                 495     


Arg Glu Cys Leu Leu Glu Gln Ile Lys Lys Leu Lys Gly Gln Leu Glu 
            500                 505                 510         


Glu Arg Gln Lys Ile Gly Lys Leu Asp Asn Leu Arg Ser Glu Asp Asp 
        515                 520                 525             


Val Leu Glu Asn Gly Thr Asp Met His Val Met Asp Leu Gln Arg Asp 
    530                 535                 540                 


Ala Asn Arg Gln Ile Ser Asp Leu Lys Phe Lys Leu Ala Lys Ser Glu 
545                 550                 555                 560 


Gln Glu Ile Thr Ala Leu Glu Gln Asn Val Ile Arg Leu Glu Ser Gln 
                565                 570                 575     


Val Ser Arg Tyr Lys Ser Ala Ala Glu Asn Ala Glu Lys Ile Glu Asp 
            580                 585                 590         


Glu Leu Lys Ala Glu Lys Arg Lys Leu Gln Arg Glu Leu Arg Ser Ala 
        595                 600                 605             


Leu Asp Lys Thr Glu Glu Leu Glu Val Ser Asn Gly His Leu Val Lys 
    610                 615                 620                 


Arg Leu Glu Lys Met Lys Ala Asn Arg Ser Ala Leu Leu Ser Gln Gln 
625                 630                 635                 640 


<210>  914
<211>  1674
<212>  DNA
<213>  Homo Sapiens

<400>  914
ggcctttgtc tctcgtgccc gcacgtgcgt gtctcggtca gtagccctgc gcttctcctt       60

cactctcggc ggttcaggag gctctgccgc agccggggcc ctcctgtgac ctgcatgtac      120

tgggggattc gcagggagga tgtcgggaca ccccggaagc tgggaaatga actcggttgc      180

ctttgaggat gtggctgtga acttcaccca ggaggagtgg gctttgttgg atccttccca      240

gaagaatctc tatagagacg tgatgcagga aaccttcagg aatctggctt ccataggaaa      300

caaaggggaa gaccagagca ttgaagatca gtacaaaaat tcttcaagaa atctaagttc      360

atttcagata catcagagaa atcacactgg agagaaaccc tatgaatgta tggaatgtgg      420

gaaagcctta ggtttttccc gttctcttaa tagacataaa aggattcaca ctggagaaaa      480

acgctatgaa tgtaagcaat gtgggaaagc cttcagtcgt tccagtcacc ttcgtgacca      540

tgaaagaact catactggag agaaacccta tgaatgtaag cactgtggga aagccttccg      600

ttactccaat tgccttcatt accatgaaag aactcacact ggagagaaac cttatgtgtg      660

catggaatgt ggcaaagctt tcagttgtct cagttccttg caaggacata taaaggctca      720

tgctggtgaa gaaccctatc catgtaagca atgtgggaaa gccttcagat acgccagttc      780

ccttcagaaa cacgagaaaa ctcatattgc acagaaaccc tatgtatgta acaattgtgg      840

taaaggcttc agatgttcca gttcccttcg tgaccatgaa aggactcata ctggagagaa      900

accctatgaa tgtcagaaat gtggcaaagc ctttagtcgt gctagtaccc tttggaagca      960

taaaaaaact catactggag aaaagcccta taaatgtaaa aaaatgtaaa ggctttaatc     1020

actacagttt ttgtcaaaaa catgaacagt cacatacttg agagaaactg tgaatgtaag     1080

gtgtaggaaa gtacttaatt ttcccagatt tcctcaaata catgaaacga atcaaactgg     1140

agataaaccc tatgactata agcaataagg taaagcattc aatttttcca tttctttttg     1200

aaaacttgaa aggactcact gaagaaaatc catatgaatg tttaaaatgt ggtaaggcct     1260

gcagttgttc cagtggtatt tgatggtata acataactca ttctagagaa aaactttatg     1320

aaggtatcga atgtgagaat gccttcattt atcctataac tcactcagag acacatggta     1380

acacatactc cagattgacc ttataaataa aagaatgccc accagattga aatcctagaa     1440

atacagaaaa ttctgaattt taacaattac tttaaaggtc atgtgaaaac tcccactgga     1500

aataaatcct gtaaatgtaa atattatgga aaaccttatg gaaaataatt atagtacaat     1560

tctcaagaaa attcactatg tgaatgagat gttttaggag ctataaataa attgaatata     1620

ttggttgctc atttttgaag agagtctcta gaatatagat tttcacttct tttg           1674


<210>  915
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  915

Met Ser Gly His Pro Gly Ser Trp Glu Met Asn Ser Val Ala Phe Glu 
1               5                   10                  15      


Asp Val Ala Val Asn Phe Thr Gln Glu Glu Trp Ala Leu Leu Asp Pro 
            20                  25                  30          


Ser Gln Lys Asn Leu Tyr Arg Asp Val Met Gln Glu Thr Phe Arg Asn 
        35                  40                  45              


Leu Ala Ser Ile Gly Asn Lys Gly Glu Asp Gln Ser Ile Glu Asp Gln 
    50                  55                  60                  


Tyr Lys Asn Ser Ser Arg Asn Leu Ser Ser Phe Gln Ile His Gln Arg 
65                  70                  75                  80  


Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Met Glu Cys Gly Lys Ala 
                85                  90                  95      


Leu Gly Phe Ser Arg Ser Leu Asn Arg His Lys Arg Ile His Thr Gly 
            100                 105                 110         


Glu Lys Arg Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Arg Ser 
        115                 120                 125             


Ser His Leu Arg Asp His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr 
    130                 135                 140                 


Glu Cys Lys His Cys Gly Lys Ala Phe Arg Tyr Ser Asn Cys Leu His 
145                 150                 155                 160 


Tyr His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Met Glu 
                165                 170                 175     


Cys Gly Lys Ala Phe Ser Cys Leu Ser Ser Leu Gln Gly His Ile Lys 
            180                 185                 190         


Ala His Ala Gly Glu Glu Pro Tyr Pro Cys Lys Gln Cys Gly Lys Ala 
        195                 200                 205             


Phe Arg Tyr Ala Ser Ser Leu Gln Lys His Glu Lys Thr His Ile Ala 
    210                 215                 220                 


Gln Lys Pro Tyr Val Cys Asn Asn Cys Gly Lys Gly Phe Arg Cys Ser 
225                 230                 235                 240 


Ser Ser Leu Arg Asp His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr 
                245                 250                 255     


Glu Cys Gln Lys Cys Gly Lys Ala Phe Ser Arg Ala Ser Thr Leu Trp 
            260                 265                 270         


Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Lys 
        275                 280                 285             


Met 
    


<210>  916
<211>  1619
<212>  DNA
<213>  Homo Sapiens

<400>  916
ggctcatttg cagacatatg ggtgattggt acagtaggtt tataaacaga agtttaaact       60

tgtaagctta agcttccgtt tataaacaga agtttaaaat tataggtcct gtttaacatt      120

cagctctgtt aactcactca tctttttgtg tttttacact ttgtcaagat ttctttacat      180

attcatcaat gtctgaagaa gttacttatg cagatcttca attccagaac tccagtgaga      240

tggaaaaaat cccagaaatt ggcaaatttg gggaaaaagc acctccagct ccctctcatg      300

tatggcgtcc agcagccttg tttctgactc ttctgtgcct tctgttgctc attggattgg      360

gagtcttggc aagcatgttt cacgtaactt tgaagataga aatgaaaaaa atgaacaaac      420

tacaaaacat cagtgaagag ctccagagaa atatttctct acaactgatg agtaacatga      480

atatctccaa caagatcagg aacctctcca ccacactgca aacaatagcc accaaattat      540

gtcgtgagct atatagcaaa gaacaagagc acaaatgtaa gccttgtcca aggagatgga      600

tttggcataa ggacagctgt tatttcctaa gtgatgatgt ccaaacatgg caggagagta      660

aaatggcctg tgctgctcag aatgccagcc tgttgaagat aaacaacaaa aatgcattgg      720

aatttataaa atcccagagt agatcatatg actattggct gggattatct cctgaagaag      780

attccactcg tggtatgaga gtggataata taatcaactc ctctgcctgg gttataagaa      840

acgcacctga cttaaataac atgtattgtg gatatataaa tagactatat gttcaatatt      900

atcactgcac ttataaaaaa agaatgatat gtgagaagat ggccaatcca gtgcagcttg      960

gttctacata ttttagggag gcatgaggca tcaatcaaat acatttaagg agtgtagggg     1020

gtgggggttc taggctatag gtaaatttaa atattttctg gttgacaatt agttgagttt     1080

gtctgaagac ctgggatttt atcatgcaga tgaaacatcc aggtagcaag cttcagagag     1140

aatagactgt gaatgttaat gccagagagg tataatgaag catgtcccac ctcccacttt     1200

ccatcatggc ctgaaccctg gaggaagagg aagtccattc agatagttgt ggggggcctt     1260

cgaattttca ttttcattta cgttcttccc cttctggcca agatttgcca gaggcaacat     1320

caaaaaccag caaattttaa ttttgtccca cagcgttgct agggtggcat ggctccccat     1380

ctcgggtcca tcctatactt ccatgggact ccctatggct gaaggcctta tgagtcaaag     1440

gacttatagc caattgattg ttctaggcca ggtaagaatg gatatggaca tgcatttatt     1500

acctcttaaa attattattt taagtaaaag ccaataaaca aaaacgaaaa ggcaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1619


<210>  917
<211>  265
<212>  PRT
<213>  Homo Sapiens

<400>  917

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  918
<211>  11241
<212>  DNA
<213>  Homo Sapiens

<400>  918
tccgcccgga tagccggcgg cggcggcggc ggcggcggcg gcggcggccg ggagaggccc       60

ctccttcacg ccctgcttct ctccctcgct cgcagtcgag ccgagccggc ggacccgcct      120

gggctccgac cctgcccagg ccatggccgg caacgtgaag aagagctctg gggccggggg      180

cggcagcggc tccgggggct cgggttcggg tggcctgatt gggctcatga aggacgcctt      240

ccagccgcac caccaccacc accaccacct cagcccccac ccgccgggga cggtggacaa      300

gaagatggtg gagaagtgct ggaagctcat ggacaaggtg gtgcggttgt gtcagaaccc      360

aaagctggcg ctaaagaata gcccacctta tatcttagac ctgctaccag atacctacca      420

gcatctccgt actatcttgt caagatatga ggggaagatg gagacacttg gagaaaatga      480

gtattttagg gtgtttatgg agaatttgat gaagaaaact aagcaaacca taagcctctt      540

caaggaggga aaagaaagaa tgtatgagga gaattctcag cctaggcgaa acctaaccaa      600

actgtccctc atcttcagcc acatgctggc agaactaaaa ggaatctttc caagtggact      660

ctttcaggga gacacatttc ggattactaa agcagatgct gcggaatttt ggagaaaagc      720

ttttggggaa aagacaatag tcccttggaa gagctttcga caggctctac atgaagtgca      780

tcccatcagt tctgggctgg aggccatggc tctgaaatcc actattgatc tgacctgcaa      840

tgattatatt tcggtttttg aatttgacat ctttacccga ctctttcagc cctggtcctc      900

tttgctcagg aattggaaca gccttgctgt aactcatcct ggctacatgg cttttttgac      960

gtatgacgaa gtgaaagctc ggctccagaa attcattcac aaacctggca gttatatctt     1020

ccggctgagc tgtactcgtc tgggtcagtg ggctattggg tatgttactg ctgatgggaa     1080

cattctccag acaatccctc acaataaacc tctcttccaa gcactgattg atggcttcag     1140

ggaaggcttc tatttgtttc ctgatggacg aaatcagaat cctgatctga ctggcttatg     1200

tgaaccaact ccccaagacc atatcaaagt gacccaggaa caatatgaat tatactgtga     1260

gatgggctcc acattccaac tatgtaaaat atgtgctgaa aatgataagg atgtaaagat     1320

tgagccctgt ggacacctca tgtgcacatc ctgtcttaca tcctggcagg aatcagaagg     1380

tcagggctgt cctttctgcc gatgtgaaat taaaggtact gaacccatcg tggtagatcc     1440

gtttgatcct agagggagtg gcagcctgtt gaggcaagga gcagagggag ctccctcccc     1500

aaattatgat gatgatgatg atgaacgagc tgatgatact ctcttcatga tgaaggaatt     1560

ggctggtgcc aaggtggaac ggccgccttc tccattctcc atggccccac aagcttccct     1620

tcccccggtg ccaccacgac ttgaccttct gccgcagcga gtatgtgttc cctcaagtgc     1680

ttctgctctt ggaactgctt ctaaggctgc ttctggctcc cttcataaag acaaaccatt     1740

gccagtacct cccacacttc gagatcttcc accaccaccg cctccagacc ggccatattc     1800

tgttggagca gaatcccgac ctcaaagacg ccccttgcct tgtacaccag gcgactgtcc     1860

ctccagagac aaactgcccc ctgtcccctc tagccgcctt ggagactcat ggctgccccg     1920

gccaatcccc aaagtaccag tatctgcccc aagttccagt gatccctgga caggaagaga     1980

attaaccaac cggcactcac ttccattttc attgccctca caaatggagc ccagaccaga     2040

tgtgcctagg ctcggaagca cgttcagtct ggatacctcc atgagtatga atagcagccc     2100

attagtaggt ccagagtgtg accaccccaa aatcaaacct tcctcatctg ccaatgccat     2160

ttattctctg gctgccagac ctcttcctgt gccaaaactg ccacctgggg agcaatgtga     2220

gggtgaagag gacacagagt acatgactcc ctcttccagg cctctacggc ctttggatac     2280

atcccagagt tcacgagcat gtgattgcga ccagcagatt gatagctgta cgtatgaagc     2340

aatgtataat attcagtccc aggcgccatc tatcaccgag agcagcacct ttggtgaagg     2400

gaatttggcc gcagcccatg ccaacactgg tcccgaggag tcagaaaatg aggatgatgg     2460

gtatgatgtc ccaaagccac ctgtgccggc cgtgctggcc cgccgaactc tctcagatat     2520

ctctaatgcc agctcctcct ttggctggtt gtctctggat ggtgatccta caacaaatgt     2580

cactgaaggt tcccaagttc ccgagaggcc tccaaaacca ttcccgcgga gaatcaactc     2640

tgaacggaaa gctggcagct gtcagcaagg tagtggtcct gccgcctctg ctgccaccgc     2700

ctcacctcag ctctccagtg agatcgagaa cctcatgagt caggggtact cctaccagga     2760

catccagaaa gctttggtca ttgcccagaa caacatcgag atggccaaaa acatcctccg     2820

ggaatttgtt tccatttctt ctcctgccca tgtagctacc tagcacacca tctccctgct     2880

gcaggtttag aggaccagtg agttgggagt tattactcaa gtggcaccta gaagggcagg     2940

agttcctttg gtgacttcac agtgaagtct tgccctctct gtgggatatc acatcagtgg     3000

ttccaagatt tcaaagtggt gaaatgaaaa tggagcagct agtatgtttt attattttat     3060

gggtcttgag tgcatttgaa ggtgtccttc agttcccacg tagagagagt gtggattata     3120

ttacatgata acctacctgg ggaacagtcc agaaagctat agaacaagta ttttgctgga     3180

aatcctaatt gaggacttaa gacttcctgg gttaaggatg tggccgtgtg tgtgtgtgtc     3240

tgcctgtggt tgtatgtgtc cttgtgatta taagattaac ctgctgtgtg tgttaattcc     3300

aggcagggaa ttagcacaaa aggtttagga aggaatcttt ttttaaagac ttccatctac     3360

tgtggtatta tacccaagcc tagtgtgtat tacaacttca acactcccct ttggcttata     3420

ttaccatgtg catagctaaa gtcttctatt tttagaacac cttctgtctg ttctttcccc     3480

atcaactcct tcctcatcct tcttggtgtt ctgtcatggg ccatgggctt gctatggcca     3540

gccttactga ggccaagcag cttatgggat gttctttatt gtgtgtgatg gtattggttt     3600

gtttggtaga taagtgggag gaaaagtact gttgctacac tattataggc atgtttgata     3660

ctagcagcta acactggtca ctccaaagca ctgtttctat aggaacattg aagctattaa     3720

gatgttttga ttatcctaat tacataatga ccgatttgag atagaggcct ttaaatacat     3780

tccatgccct ccccagaaaa tagtctgtgg gagtcagttg ccttggtgcc aggtatgtgt     3840

tctgatgtag gtcatgagtc tttctactta atgggaaggg aagaacattt gtttccagga     3900

tgactttctg gccagaatac cggaaagctt ttaggaagct tcgttcacat gctatttaaa     3960

tgcacaaaat agacagtaag gatttatctg ttcagttttt cttcccagtg aattaatttc     4020

agcttatatg ggtgtcttca tttgaacatg aggaatatta ggttatattt tcagcagtgg     4080

ttttttcctt tgccctttaa ggagtgggga taatgtccac ggtggcccag cctcttgctg     4140

atggcacctt ccctgcattg ctgcctcccg atgatgtggt tcttttcttg tgcctgtggc     4200

tttgggaatg taacatctct ttcctccttt ccttcccttt tcctcttcac ctgaggtcct     4260

aaatactctc tgtaattact gtgttcttca cggtaattag acatcattca gtgaataaat     4320

tactgtagtc aaagacagta tgggctggca gtttgtgtaa ttgcaagttc ataaagagaa     4380

ttgagggtcc agttgggaga actattagtc agttctttta tatgctgata aatgatccct     4440

cgagttcagt tagtattctg tccagagtgt ttagctcact ttcttagcag tgtgtaagct     4500

ttctccatgt cagaagcaag cctgctcttt gataaatctg tcttcctgaa aatctaaatc     4560

atgcttttgt ctttagatct acacagaaat gaccctcctt ggatcagttt tctttccagt     4620

ctaatcatct ttggaactaa aacttgttct aactcgtctc ttggcattca gctactccta     4680

gatcttttgg ttttatcccc tggcctcaga gccatttata ttcccagagt aggcagtaca     4740

ggatctcgtg ttgatttgct gtggttaccc agtgtcttct ctacatggca taaagcggca     4800

aagcccacca ttaggtgagg cggtcccgag ttgaggtaga gtggggcaga ggaagatggc     4860

agtgaatatc aaacagtaga ccgccatcaa cttctaacag ccagtacaca cactgtttca     4920

ttttgaggta acgttcagtt ttgcattttg tttaaatatt gaaggcctag acaaagaact     4980

agaaaaaaaa aagcagtttc caggcccatc catattgtaa tttttcttta tctgcagata     5040

ttgcctgtag tctaaagatc tctttggaag acaaagcatt ggctatatat cttttgcctt     5100

ttccatgcat ctaaatcttc tctggagatt atctccctac tgtgtaggtt aagggcagtc     5160

tcgacttttc cttttttgag tcctgtgtgg ctctttgaat cagcgtgaaa ctgaggctcc     5220

agctccctgt gttgtgtgtg tgtgccatcc atgggcttgg gtgtcagttt gtcacaggta     5280

tctgccagca ttcaaggttt tggatcattt catgaggatc tttcctttga ctgggtgctg     5340

tgaggacaca cctgggtctg tgcctgagat tgccaggcaa gattaaggaa agttttcatg     5400

tggcttttgt tttgaggtta ttctcaaaac cttaatttct tatattttct gttgactaag     5460

gcaccagtaa cccattcttc accctccatt tgtatggcaa tttaaaagtc tttggctttg     5520

ctctgaattt aattaaaact gccttttatg aacagacttc gagttttgcc attttgggca     5580

agcccttccg cttgtccctt cctagtggct aataaagtaa aaaaacccac actactttgt     5640

tctctttttc tcatattcat tgggctgttg tattcagcca gtctcatgct ttccctgggt     5700

cttcacggat tgctttccaa gctgccttgt tgcggggttg ctgcagagca gcaactggac     5760

ctttccagct gtcgccatgt tccttccact aaagtagagg gttcttaaaa tggaaaaacc     5820

tgtgggctct tcatatacct ccctttagtt aagtaataga ccaggcagct tctcatctca     5880

gcatttacct gttaatattt ttgtgaatag tgctctctac ctgtgggtgg ccgttctctt     5940

ccacttgctc gtctcccccc agccccattc tgcataatct accattcttc tcctctcttt     6000

ctcttcttat acagaccctc attactgggg cccaagatgt gggatactac tgttagtatt     6060

atttaactat tttgtagatt taaaagattt ctggttaagg gaggtggggg tcactgttca     6120

tcactcttaa aatatgtgtt ttctctatag aaaagtaaaa tgtgtttatg gtcccaaaca     6180

gtcaactcac aaatttttat aacaaaattt ccttgtaaaa actagggacc atctatatat     6240

tccctttaag atctagttct ttttgtaggt gttcagcaat ggtgataaag cagaatattc     6300

tcctacctca cgtcattaaa gtcagaagat tatagacctt ctcaaactat aagtccctct     6360

tcttgccgtt ggcctttctg actctggaat gaccactgtt cattgaaaaa tagttttctg     6420

actattggtc tggctctaac agtttgtttg ttcatccagc aaatgtttat gagtgatgac     6480

catgtgccag aaatgtcagg tatgtgtcct tcccttggcg ccacatagta gtttactaat     6540

gtttggggga ttgtacttgg actgtcatag cctctgcgtt tgaccttaaa atagctcttc     6600

ccagtaagat tgtgcaattt ttattcacag ctcttccatg tagacttacc tttcctcata     6660

gagctatcct ggttaataac aggccaagat tctcccatta tcccctgttg tctcctgtag     6720

ctttgataat gcctgggaga ttccttggtg taagtgtcat ggataccgac tgtttttatg     6780

ttggaatttg ttccaacata attagaatct gtttggtgag ttgaaaggta agttggctca     6840

gagttgcaca gtagggcatt aaatgtttaa gcaaagcatc tgcccacact cccctttcca     6900

atctagtgcc ttccttgaac tttttcctga gctgctacgt ccctaatccc ccttgttggg     6960

aggattttcg tatcaccctt atgggacctg tcaccatgtc ctgtactatt tggaattggt     7020

tttccagtct ttcaacaacc gttgtggcta actatgtttt agaagggctg gaggtgtggg     7080

ccctgtcttc gggtctcagg acccaaagat cctttagtca gttgttgggt cttccaagag     7140

ccagacatta atacagattg aactccatca gtcccctaat tgtcagcctt tacctccctc     7200

ccagagcaag gagtttaggg attctaaagc ttagtgtcca cacatcattc taccagacct     7260

tagagcttta gaagctcaat ctaaaatact gtaactcagc ataaactatt actatcactc     7320

ctttgaactc agtctccatg agcagtgttt tgttggaaat acatagaacg gcttaatgcc     7380

tagagggtgg tggatagtga aggacggtca aggttatatt tttgactgct tagggattct     7440

ttggatccaa gaaacagaaa tgttcaagcg gaataaagga gggagtggag ttgtggtaag     7500

gatgcagggt atttcgcaga acccaggacg ggaagtgcct ttggttcttg ggtggagctg     7560

gaactgcaga gctttgcacc tagtcctttc tcccgcttca cagtctgctt atggtatatg     7620

tggcccccaa ataggcactc tagtcctcaa gtctacacca ccttccaact ctggggatca     7680

ccatgaacaa attctcaatt tcccatactt aatttttttt ttttttgaga tggagtctcg     7740

ctgtgtcgcc caggctggag tgcagtggtg cagtctcaac tcaccacaac ctctgcctcc     7800

caggttcaag cagttctctg cctcaacctc ccgagtagct gggattacag gcgcctgcca     7860

ccatgcccag ctaatgttca tatttttagt agagacaggg tttcaccgtc ttggctaggc     7920

tggtcttgaa ctcctgaccc tcatgatcca cccacctcgg cctcccaaag tgctaagatt     7980

acaggcgtga gccaccgcgc ccggcccata cttcgtattc ttaaaaaaaa ctacactcag     8040

cccagcacat tgatcaagta tctatctctg agcagttggc cttgccaggg agagcagaga     8100

tgtggcaggc tccttcagct ggagacaggg agcttctcag agaagtgagc agagactcca     8160

cagacaccct aaaaaggctt ctactcaaga agtaaagcca ctactcctgc ctttttgctt     8220

agtggacagg aaggcacagg agtttgtctg ggacatcata gaaattctta ggtttaactt     8280

aattctggtc attgtcttct ttatttcctg tttttcttcc ctttgtcagt cttcgcatcc     8340

aagatttctt ccctccctct tgtgggccag cctgtcctgt tccagagcta gcctgttcct     8400

gggtagcctt ccttagcctc cattcagcct caggtctttt gccttcttcc gtgtttattt     8460

agagagcaga atctaataac gggttccact gtagccacta tccatggact tctgggtcct     8520

cttcaggttt gagtgcttga aaatgttcat tctctgggct tgtggcctgt ctcctccact     8580

ctcctcctca ccctctcgct ccttcctgtg tgagggccgc tctgcagtaa tgttctcagg     8640

caagccttcc taggcacctc agaaactact ttgccagagc cagtaagaat atataatatt     8700

ggagcagttg ccaggataga aattaaatat agattccagt ttaggataga gtttttaccg     8760

agagctcttt agacagtata cctgtgtctt ctctggcaat tgctttcatt ttagtcctat     8820

ataaaagctt tccttttctg ttttttttta aaactatgct tttgcttgcc taaatctttt     8880

gatcttatat ttctctcatc tcagagcctg tcctgagttg taaggtattt catactgcct     8940

tacttaaaag ttttttaaac tactagagtc atttgataca cacagaagtt acctaataat     9000

ccaaagatgt ccatcaaggg aggaagggtg ggtcatcaga ctttgccttt gatgttgtag     9060

actaggctcc tgagttaagc agcagaggga cagcagtgcc atgtgccttc actgtgtccc     9120

aggaaatctg ggttggttcc agtgggaaat accagtattt cttggttctg gaaagtagca     9180

aaagagtagg agatggggaa atagggatgg ggagagcaag ccccgcatgt ccatggcgag     9240

tcaggtgggg agcacgggtg gaagggccgg ctgttgacag acagactaag ctgtgtggtg     9300

ctcttgccgc cccttcctgg gtacagagct tgagaaaaat gcagccgacc actccctgtg     9360

tttgtacaga gcaaagccca aaagccaacc tcagatctcc tgatttggca gctgaagaaa     9420

tcagcagagt cctgattgcc tgattcagtc ccaaaaatga atgtcaggcc ccgccccctc     9480

cccaccaaca ttgcctctcc tacattctcc ttctgcccct aaatcagaca ggaggccaga     9540

gaggagtatt gctcaatgcg tgctatgtgc aactcctcag gccttgtgcc acctccatgc     9600

tgagccctga agcagggtgt cctgggtgcc tgtgtgtcag ctccctcctc tctacctacc     9660

tctgaccttc ttgtgggtga gggtggccat gcttatggcc atcttaaaac tggagaggca     9720

gagaactact tatgagtctg tagaccacgt gttgtcttcc atggcctgtt tctcctgctg     9780

tctgggtgag tgagcctgca acgcaatgcc catgagagta aatgcctcct gacctaccct     9840

gctcagcact gttctagtgt cttggccttg aaagaaaagc ctgacttcct gctgacacat     9900

gtggtagggg catggcagct atgaggcacc tcctacgtct gttttctggc tgtggtgact     9960

tgggattttt aaccttatat atctttttcc tttactcaaa acaaaacaat ttttagcaca    10020

ctgaaaaaaa aaaaaagcca aatgttttgt gcctttctaa ggcagcactg tatcccaggc    10080

tgcattttag gacttaatat ggaaatacca gagtctgagc tcctctacct tgagtttcat    10140

tagtccttag tgtctaggag acaggaaaga atgctctctg tgactggaga ggtgacatgc    10200

aggtgcagtg tgtctggagt ccctttcccc tgctgtgaga cttcagtgga ggagagaagc    10260

attgtaccct gggatcattt ggttggttcc aatcacaagc ttagttatca ggttgcatgc    10320

cttgtctcct gcaaaagaca gaatgtttca caattcccag gtaaactctg gaccattcca    10380

agtgtcctag ccttctgatg acattaatta cctagttgtg tcgaggagta taggatggac    10440

tctcctgaga aggggaggtt ggtggctttg tcttttcttt ttgctggatc ctgaactggt    10500

ctagacctcc tgcccccacc ccccagcccc catcagatgt ggctggcctt tcatttgaag    10560

gcttcagact taaagcatta agcagctagt gccctctgca gggcctggtt tccccaggga    10620

agggcagcaa ggaacatggg accagaagcc tgtcctcagt aatgtgacta tagtgagctt    10680

tagcaaaagt ttttctatat aatgacatct tacttatctt ttaccctttc ctcagttttc    10740

ccctgccttt aactaataaa gaattgggag acagaaattt taaagtcctc cttattcaag    10800

attttgaaat tcttagcctg ggagtgctgg agagaacctg atgctttctc cagaatgaag    10860

agtcccaatt tgtatatcag tgttaagaag aaaacaaaac aaacacatag gtgagatttt    10920

cgtggactat tttaaaaatg tgtcattaat ataaaaaatt tatattagca gtatttaatc    10980

attctcacct gtaaagaata agaaaaacag aaggtaaata ttcttacaga gaatagcaga    11040

gctttaagat tcattttcat tttaagtcca ttttattttg ccagtgtatt aatgtttaga    11100

agtctgtttt actaatgtta tttattaatt ttttttcatt tccatacaca gttagttaac    11160

taaagagctt tttcaagcac ccatgtctgt aaaaaaatat ttttaaataa agtttctttt    11220

gttgtagcag aaaaaaaaaa a                                              11241


<210>  919
<211>  906
<212>  PRT
<213>  Homo Sapiens

<400>  919

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  920
<211>  3558
<212>  DNA
<213>  Homo Sapiens

<400>  920
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag       60

caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt      120

caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg      180

cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct      240

cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc      300

gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat      360

ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca      420

gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca      480

gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag      540

atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat      600

gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag      660

gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg      720

ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc      780

gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc      840

tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact      900

gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc      960

catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag     1020

tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt     1080

tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg     1140

ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac     1200

tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg     1260

cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg     1320

ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc     1380

aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac     1440

attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg     1500

cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc     1560

agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct     1620

cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa     1680

tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg     1740

agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg     1800

gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg     1860

gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc     1920

agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc     1980

tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg     2040

gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc     2100

ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc     2160

ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc     2220

cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt     2280

gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg     2340

gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag     2400

gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact     2460

ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg     2520

ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt     2580

gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc     2640

aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt     2700

gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt     2760

gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag     2820

cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa     2880

ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc     2940

attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct     3000

gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt     3060

gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca     3120

cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc     3180

cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg     3240

cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc     3300

cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg     3360

gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg     3420

gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt     3480

ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattccaaa     3540

aaaaaaaaaa aaaaaaaa                                                   3558


<210>  921
<211>  582
<212>  PRT
<213>  Homo Sapiens

<400>  921

Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  922
<211>  816
<212>  DNA
<213>  Homo Sapiens

<400>  922
cgcggccgct cctgcgggcg gaagcctcct ggcgctcggc cctgcgcccc tccccccggc       60

gcgcggcccc gcccaggacg aggggcggtg ggcaggcagc gctgggtcca gtggtcgggg      120

gaaggcgagg attaccctcc cggaggcgtt gtctgcgact cggcggaggc tccaacttcc      180

agtggcccgg tcgggaaaga tcagagcctc ctaagaaata tccagaagtc aagccatgga      240

tccacctgca cgtaaagaaa aaaccaaagt taaagaatct gtcagcagag ttgagaaggc      300

caaacagaaa tcagcccagc aggagctgaa gcagagacaa agagcagaga tctatgccct      360

caacagagtc atgacagaac tggagcagca gcagtttgat gagttctgta aacagatgca      420

gcctcctgga gaatgaggcc ccaggttcaa accagatggg atcctgagag ctttgagagg      480

gtgttgccag ttttaagctg agatggccca tttggagcct tacagaacta gaccagaaga      540

catttgtgga taaatctgaa ctcacttcct gtgtgtaact tctaacttca ctggttcctc      600

ccatctgaat tggccacatg cttgctgaag agacttgttt tcttcttcta agacagtggt      660

tttgtttttt gggttttttt aaaaaaaaaa aaaaaacaca cacaaaaaac actttttcta      720

ttgtttgaga aaaatcagtg tttctcatga aactctatat cttctccaaa aatacaaata      780

aaatactaat aaaatgttaa aaaaaaaaaa aaaaaa                                816


<210>  923
<211>  66
<212>  PRT
<213>  Homo Sapiens

<400>  923

Met Asp Pro Pro Ala Arg Lys Glu Lys Thr Lys Val Lys Glu Ser Val 
1               5                   10                  15      


Ser Arg Val Glu Lys Ala Lys Gln Lys Ser Ala Gln Gln Glu Leu Lys 
            20                  25                  30          


Gln Arg Gln Arg Ala Glu Ile Tyr Ala Leu Asn Arg Val Met Thr Glu 
        35                  40                  45              


Leu Glu Gln Gln Gln Phe Asp Glu Phe Cys Lys Gln Met Gln Pro Pro 
    50                  55                  60                  


Gly Glu 
65      


<210>  924
<211>  6087
<212>  DNA
<213>  Homo Sapiens

<400>  924
atgccggggg ccggagcccg ggcggaggag ggcggcggcg gcggcgaggg cgcggcgcag       60

ggggcggccg cggagcccgg ggcgggtccg gcgcgggagc cagcgcggct gtgtggctat      120

ctgcagaagc tgtcgggcaa gggccccctg cgtggctacc gcagccgctg gttcgtgttc      180

gacgcgcgcc gctgctacct ttactatttc aagagtccgc aggacgcgct gcccctcggc      240

cacttggaca tcgcggacgc ctgcttcagc taccagggcc ccgacgaggc ggcggagccg      300

ggcacggagc cgcccgcgca cttccaggtg cacagcgcgg gagccgtcac ggtgctcaag      360

gctcccaatc gtcaactcat gacttactgg ttacaggagc ttcagcagaa gagatgggaa      420

tattgtaaca gtcttgacat ggtcaagtgg gacagcagga cctctccaac tcccggggat      480

tttcctaagg gtcttgtagc cagagataac actgatttaa tttacccaca cccaaatgct      540

tctgcagaaa aagccagaaa tgtcctagct gtggagactg tgcctggaga gctggtggga      600

gaacaagctg caaatcagcc cgccccaggg catccaaatt ccattaattt ttactctttg      660

aaacagtggg gcaatgagct caagaattcg atgtcttctt tccgtcctgg gagaggacat      720

aatgatagtc ggaggactgt gttttatacc aatgaagagt gggaactttt agacccaacc      780

cctaaggacc tagaggagtc catagtacag gaagaaaaga agaagctgac ccctgaagga      840

aacaaaggag taactggctc aggattcccc tttgattttg gacgtaaccc ctacaaagga      900

aagcgccctt tgaaagacat aattgggtcg tacaaaaatc gtcacagcag tggtgaccct      960

tcaagtgaag gcacatcagg cagtggcagc gtcagcatca ggaagccggc ctccgaaatg     1020

caactgcagg tccagagcca gcaggaagag ctggaacagt taaagaaaga cctgtccagt     1080

cagaaggagc ttgttcgact gctccagcag acagtccggt catcccagta tgacaagtat     1140

ttcacaagca gccggctctg tgagggggtc ccaaaggaca cgctcgagct tctgcaccaa     1200

aaggatgatc agattctggg ccttaccagc cagctggaga ggttcagctt ggagaaggag     1260

agtcttcagc aggaagtaag gacgctgaag agcaaagtgg gcgagctcaa cgagcagctg     1320

ggaatgctca tggagaccat ccaagccaag gacgaggtca tcatcaagct cagcgagggc     1380

gagggcaacg ggcctcctcc caccgtggcg cccagctccc cttcggttgt gcctgttgcc     1440

agggaccagc tggaactgga caggctgaaa gataatctac aggggtacaa aacccaaaac     1500

aaatttctaa ataaggagat tttggaactc tcagctctac gaagaaatgc agaaaggaga     1560

gagagggatc tgatggcaaa gtattctagc ctggaagcca agctctgcca gatagaaagt     1620

aaatacctga tattgctcca agaaatgaag acaccagtgt gctcagaaga ccaggggccc     1680

acccgggagg tcatagccca gttgctggag gatgctctgc aggttgagag ccaagagcag     1740

ccggagcaag catttgttaa acctcatctt gtcagtgaat atgatattta tgggttcagg     1800

actgtacctg aggatgatga ggaagagaaa ttggttgcca aggtccgcgc gttggatctg     1860

aagactctct acctcacaga aaaccaggaa gtctccactg gggtcaagtg ggaaaactat     1920

tttgcaagta cagtgaacag ggagatgatg tgctctccag agttaaaaaa cctcatccgt     1980

gcgggcattc cccacgagca ccgttccaag gtgtggaagt ggtgtgtgga ccgtcacacc     2040

aggaagttca aggacaacac tgagcctggc cacttccaga ccttgctgca gaaggcgctg     2100

gagaaacaga acccagcctc caagcagatt gagctggact tgctgcgaac tctgcccaac     2160

aacaaacatt actcctgccc cacctcagaa ggcatacaga agttacgcaa tgtcctcctc     2220

gccttctcct ggcggaatcc agatatcggc tactgtcaag gcctaaacag gttggtggca     2280

gtggccctcc tgtacctgga acaagaagat gctttctggt gtctcgttac catagtggaa     2340

gttttcatgc ctcgagacta ttatacaaag actcttttag gatcccaggt ggaccagcgg     2400

gtgttcagag accttatgag tgagaagctg cctcggttgc atggccactt tgaacagtac     2460

aaagtcgact acactctcat cactttcaac tggtttctgg tggtatttgt ggatagtgtc     2520

gttagtgaca tcctctttaa aatatgggac tctttccttt atgaaggacc aaaggttatt     2580

ttccgttttg ctctggcact ttttaagtac aaggaagagg agattttgaa attgcaagat     2640

tcgatgtcta tatttaagta tctccgctac ttcactcgca ctatccttga tgctaggaag     2700

ctgatcagta tctcctttgg ggacctgaac cctttccccc tacgccagat ccggaaccga     2760

cgcgcctacc acttggagaa agtccggctg gagctgaccg agctggaggc catccgtgag     2820

gacttcctgc gtgagcggga caccagccct gacaagggtg agctggtcag tgacgaggag     2880

gaggatacct gagtgggctc gggatgctgc tcttccttcc ttcacaacca aagtgtgccc     2940

aaagggtgaa agtgcactta aaagccagaa tgtaacgtgt gtgtcctctg gggatctgct     3000

gggcagatgt cccaagccag gctgcccttc ctcatttccc actgtgcggg gggcaggggt     3060

gggaggtcta atctgtttac aaccatttcc gtgccatgct tttggttaca cgtatctcag     3120

tcacgctttc tgcctggttg gtggatcctc aggcttacca gtggctattt gcaagagcct     3180

gtttccagcc tccgtcagcc tgtcggtgct ctgaccctct gaaaccttgc tttgctgggc     3240

atctccccat attctctctc ctgtacatag tgggcagtgg tgtgtggttt tgaatggcag     3300

tgctataaag gatgccagct gtgctttagg cacctgtagg ccagagggtt gctgcctcag     3360

gcataaggtt ggtatgaaaa ggggctgcct tagaaaagca ggcacatccc ttgttcagaa     3420

atggccactg taggaaagcc tgtgaacctc ccaccagtgg ctttaagctg ccagccatgc     3480

cccatttcta gaatagcctt tgctcttcca cacgcaaccc ttccatcagt gtcttccagc     3540

ctgcatgggg agggcctggc tgcccagaca cccaccctca cttctcatgg ccagcctgtg     3600

tttgcagatc actgggctgc tctgtcccca gcttgccccg tgccaggcat ggctctgtga     3660

gattctgtgg aatgcccttc ttgacttgtg gaaatcattc accaagtacg atgggatggg     3720

attccaagta aacagtggac cgtcatattg caaagcaggc ccacgcctgg gctggccttg     3780

gttgagggga tggaggaatg ttttcggggg tgctttgcag ggcagtggtg cagccgcagc     3840

gtgaacgctc ttggacagct gaaaaccatg gcctccttgg ggatggccag tgctcctggt     3900

gtctccacct gcctgggttg tgcaggaggc cggctgccag tgcctggggc tgggaaactt     3960

ttttgcttgg ggcaggcttg ggtgagctct cccagatgtg tgcccacccc accactgcct     4020

ggaacatcct tgttctctgc caggatgcag gggcactgtt gcctctgaca cagcagtttc     4080

tgggaactca gaggactgcc tttctgaagg ctggggagag gctttgagca aggagcttgt     4140

ttttgcttaa tcgctctaga ccatccctga tgcgtagatg tgagaggatg ttttctggca     4200

cagtgttatg aaaatacaag ataaatgatc tcagtggaat gtttcatatt acccgaaaaa     4260

aactggaaat catcctttgt tgtgaacaca ctgagactaa gaattgaagc aatgcagttt     4320

taagaagtat ttttcctatt ttttgctgtc aactttttgg caatgccacg gcaaagttgg     4380

tgtttcagca catgctagag tgagctccgg cttcgtgtct ttaaccaact ccactaatgt     4440

ttcactgggt agacggagct ggcctctata tttagccaga agcctttgcc tcttttcagg     4500

catcaaaaat gggttttgtc attgtctttg tctttgagag cagcagtttg aggtctgact     4560

ccttcagttg tcctgtgagc tgggcgttgc agtctgctcg aatcaagtgt tggaaccccc     4620

cccacccctc agcccatcgt gaaacgacag ctgtcagcct ggggggcggc tgctgaggag     4680

gtgcagcagg aatggggctg ggccctgagg ttttactttc cgagccaatg gcccctggaa     4740

catgccagca cacactgcca tgtcctgggg ctaagagctg cctttaggga caggctcgtg     4800

ttgtccagtt tgccctgaga gatgcacctg accaggggcc cgtcgtggct gcaacccacg     4860

gtggtatgtt agtgtttcca ggcagttgtc agcagctgcc gggcagtgtg tgtgtgcgac     4920

agcaggagag ttcctggagg aaagggactg gggacacttt ctcagaggtt ctcctgcctg     4980

gaatcaagtg atgcgtgtcc agaaggcaag agagggcggc tccgcctggt taaagtttgg     5040

gaacgggacg gagccaactc ctccttccag gactgtgggc cccactcttt tgcgctaaca     5100

cttcccctcc ctcgggtcac tgaggaaaga gctgctctgt cccctccagt gccctgaagg     5160

tccctggcct ccactggctg ccatggcagg gggcccttct gacaggggct gccccaagct     5220

gctgttcctc ctctgaacct tcaccccaac acccagcccg tggcccctgc aagggggacc     5280

ctgccagctg ggaaacccaa aggcctgtcc aaacgtgcgc accaggaccg aggggagctc     5340

cctcccaaca cctgctagga attgccaact tttaaatgga tggggttttt tatgggttga     5400

acctctgtta atacttttgt acactctcac tacagtttat atttttatag gctattttct     5460

caaggtgttt ctagattcca catatctatt ttatataaca agttattatg ttatgtgtgt     5520

gactcccttg tgtgtatctg tgccagcctc agcctccgag ttgcttttcc ctctggccct     5580

gactctcact gactcaccga tgtgatgtgc aggcccactt cttaccccag atagcctcgg     5640

gcgctgcctg tagtcatgct gacagctgta cagtagccgc caagactgct gacagctgga     5700

gacggttctg gtttcaacta cggtatattg atatcggaag tattctagac agatcctcgg     5760

ttgggttttc tagctacatg tttgtattgc acagatcccc acctgccatc ctatagtgtt     5820

gtcttcctgt gtgttccggg gcttctgggc agctgggcct gcccggggaa gtccttgcag     5880

gtgggaggcc atacagagac ccactgtgtg ccactgaacg tcccactgct gctgggcaac     5940

tggaggactg cagggggcgc caggtgactc tctcctttta tatcacagca gctcctgtgc     6000

tgaccttcaa gttacgtttt ggaactgtaa tactaaagga agaaataaac tactaatttg     6060

tataataaaa aaaaaaaaaa aaaaaaa                                         6087


<210>  925
<211>  963
<212>  PRT
<213>  Homo Sapiens

<400>  925

Met Pro Gly Ala Gly Ala Arg Ala Glu Glu Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Ala Ala Gln Gly Ala Ala Ala Glu Pro Gly Ala Gly Pro Ala Arg 
            20                  25                  30          


Glu Pro Ala Arg Leu Cys Gly Tyr Leu Gln Lys Leu Ser Gly Lys Gly 
        35                  40                  45              


Pro Leu Arg Gly Tyr Arg Ser Arg Trp Phe Val Phe Asp Ala Arg Arg 
    50                  55                  60                  


Cys Tyr Leu Tyr Tyr Phe Lys Ser Pro Gln Asp Ala Leu Pro Leu Gly 
65                  70                  75                  80  


His Leu Asp Ile Ala Asp Ala Cys Phe Ser Tyr Gln Gly Pro Asp Glu 
                85                  90                  95      


Ala Ala Glu Pro Gly Thr Glu Pro Pro Ala His Phe Gln Val His Ser 
            100                 105                 110         


Ala Gly Ala Val Thr Val Leu Lys Ala Pro Asn Arg Gln Leu Met Thr 
        115                 120                 125             


Tyr Trp Leu Gln Glu Leu Gln Gln Lys Arg Trp Glu Tyr Cys Asn Ser 
    130                 135                 140                 


Leu Asp Met Val Lys Trp Asp Ser Arg Thr Ser Pro Thr Pro Gly Asp 
145                 150                 155                 160 


Phe Pro Lys Gly Leu Val Ala Arg Asp Asn Thr Asp Leu Ile Tyr Pro 
                165                 170                 175     


His Pro Asn Ala Ser Ala Glu Lys Ala Arg Asn Val Leu Ala Val Glu 
            180                 185                 190         


Thr Val Pro Gly Glu Leu Val Gly Glu Gln Ala Ala Asn Gln Pro Ala 
        195                 200                 205             


Pro Gly His Pro Asn Ser Ile Asn Phe Tyr Ser Leu Lys Gln Trp Gly 
    210                 215                 220                 


Asn Glu Leu Lys Asn Ser Met Ser Ser Phe Arg Pro Gly Arg Gly His 
225                 230                 235                 240 


Asn Asp Ser Arg Arg Thr Val Phe Tyr Thr Asn Glu Glu Trp Glu Leu 
                245                 250                 255     


Leu Asp Pro Thr Pro Lys Asp Leu Glu Glu Ser Ile Val Gln Glu Glu 
            260                 265                 270         


Lys Lys Lys Leu Thr Pro Glu Gly Asn Lys Gly Val Thr Gly Ser Gly 
        275                 280                 285             


Phe Pro Phe Asp Phe Gly Arg Asn Pro Tyr Lys Gly Lys Arg Pro Leu 
    290                 295                 300                 


Lys Asp Ile Ile Gly Ser Tyr Lys Asn Arg His Ser Ser Gly Asp Pro 
305                 310                 315                 320 


Ser Ser Glu Gly Thr Ser Gly Ser Gly Ser Val Ser Ile Arg Lys Pro 
                325                 330                 335     


Ala Ser Glu Met Gln Leu Gln Val Gln Ser Gln Gln Glu Glu Leu Glu 
            340                 345                 350         


Gln Leu Lys Lys Asp Leu Ser Ser Gln Lys Glu Leu Val Arg Leu Leu 
        355                 360                 365             


Gln Gln Thr Val Arg Ser Ser Gln Tyr Asp Lys Tyr Phe Thr Ser Ser 
    370                 375                 380                 


Arg Leu Cys Glu Gly Val Pro Lys Asp Thr Leu Glu Leu Leu His Gln 
385                 390                 395                 400 


Lys Asp Asp Gln Ile Leu Gly Leu Thr Ser Gln Leu Glu Arg Phe Ser 
                405                 410                 415     


Leu Glu Lys Glu Ser Leu Gln Gln Glu Val Arg Thr Leu Lys Ser Lys 
            420                 425                 430         


Val Gly Glu Leu Asn Glu Gln Leu Gly Met Leu Met Glu Thr Ile Gln 
        435                 440                 445             


Ala Lys Asp Glu Val Ile Ile Lys Leu Ser Glu Gly Glu Gly Asn Gly 
    450                 455                 460                 


Pro Pro Pro Thr Val Ala Pro Ser Ser Pro Ser Val Val Pro Val Ala 
465                 470                 475                 480 


Arg Asp Gln Leu Glu Leu Asp Arg Leu Lys Asp Asn Leu Gln Gly Tyr 
                485                 490                 495     


Lys Thr Gln Asn Lys Phe Leu Asn Lys Glu Ile Leu Glu Leu Ser Ala 
            500                 505                 510         


Leu Arg Arg Asn Ala Glu Arg Arg Glu Arg Asp Leu Met Ala Lys Tyr 
        515                 520                 525             


Ser Ser Leu Glu Ala Lys Leu Cys Gln Ile Glu Ser Lys Tyr Leu Ile 
    530                 535                 540                 


Leu Leu Gln Glu Met Lys Thr Pro Val Cys Ser Glu Asp Gln Gly Pro 
545                 550                 555                 560 


Thr Arg Glu Val Ile Ala Gln Leu Leu Glu Asp Ala Leu Gln Val Glu 
                565                 570                 575     


Ser Gln Glu Gln Pro Glu Gln Ala Phe Val Lys Pro His Leu Val Ser 
            580                 585                 590         


Glu Tyr Asp Ile Tyr Gly Phe Arg Thr Val Pro Glu Asp Asp Glu Glu 
        595                 600                 605             


Glu Lys Leu Val Ala Lys Val Arg Ala Leu Asp Leu Lys Thr Leu Tyr 
    610                 615                 620                 


Leu Thr Glu Asn Gln Glu Val Ser Thr Gly Val Lys Trp Glu Asn Tyr 
625                 630                 635                 640 


Phe Ala Ser Thr Val Asn Arg Glu Met Met Cys Ser Pro Glu Leu Lys 
                645                 650                 655     


Asn Leu Ile Arg Ala Gly Ile Pro His Glu His Arg Ser Lys Val Trp 
            660                 665                 670         


Lys Trp Cys Val Asp Arg His Thr Arg Lys Phe Lys Asp Asn Thr Glu 
        675                 680                 685             


Pro Gly His Phe Gln Thr Leu Leu Gln Lys Ala Leu Glu Lys Gln Asn 
    690                 695                 700                 


Pro Ala Ser Lys Gln Ile Glu Leu Asp Leu Leu Arg Thr Leu Pro Asn 
705                 710                 715                 720 


Asn Lys His Tyr Ser Cys Pro Thr Ser Glu Gly Ile Gln Lys Leu Arg 
                725                 730                 735     


Asn Val Leu Leu Ala Phe Ser Trp Arg Asn Pro Asp Ile Gly Tyr Cys 
            740                 745                 750         


Gln Gly Leu Asn Arg Leu Val Ala Val Ala Leu Leu Tyr Leu Glu Gln 
        755                 760                 765             


Glu Asp Ala Phe Trp Cys Leu Val Thr Ile Val Glu Val Phe Met Pro 
    770                 775                 780                 


Arg Asp Tyr Tyr Thr Lys Thr Leu Leu Gly Ser Gln Val Asp Gln Arg 
785                 790                 795                 800 


Val Phe Arg Asp Leu Met Ser Glu Lys Leu Pro Arg Leu His Gly His 
                805                 810                 815     


Phe Glu Gln Tyr Lys Val Asp Tyr Thr Leu Ile Thr Phe Asn Trp Phe 
            820                 825                 830         


Leu Val Val Phe Val Asp Ser Val Val Ser Asp Ile Leu Phe Lys Ile 
        835                 840                 845             


Trp Asp Ser Phe Leu Tyr Glu Gly Pro Lys Val Ile Phe Arg Phe Ala 
    850                 855                 860                 


Leu Ala Leu Phe Lys Tyr Lys Glu Glu Glu Ile Leu Lys Leu Gln Asp 
865                 870                 875                 880 


Ser Met Ser Ile Phe Lys Tyr Leu Arg Tyr Phe Thr Arg Thr Ile Leu 
                885                 890                 895     


Asp Ala Arg Lys Leu Ile Ser Ile Ser Phe Gly Asp Leu Asn Pro Phe 
            900                 905                 910         


Pro Leu Arg Gln Ile Arg Asn Arg Arg Ala Tyr His Leu Glu Lys Val 
        915                 920                 925             


Arg Leu Glu Leu Thr Glu Leu Glu Ala Ile Arg Glu Asp Phe Leu Arg 
    930                 935                 940                 


Glu Arg Asp Thr Ser Pro Asp Lys Gly Glu Leu Val Ser Asp Glu Glu 
945                 950                 955                 960 


Glu Asp Thr 
            


<210>  926
<211>  3484
<212>  DNA
<213>  Homo Sapiens

<400>  926
tgccctcccg cggctgcagc cggagccgaa ggtggtggct gcacagtaga cgccccctca       60

cggcttcccc cacacgctcc cgccccctcg ctcgcccatc gcgcttccct cacaggctct      120

gcagtcctcc cccacagacg ccttccccct tggactctca ttcccttttc cacggagccc      180

cgcgctttcg tgagccccct cgaggaacct ggtctccgca tccagttacc acctcctgcc      240

tcagaggcca tctgagccct tcgcacctcg cccctcagtc cccccttccc cccccgcccg      300

cgtcgcctcg ctccctcccg cccccccatc atcccttccc tcgcagttcc cctgtcctga      360

ggggagcccc gccacgggca gcgcggcggc ggcggcagga gggagaaagt gaagcggtag      420

ctcgcgcaca ctcgcgccct cactcccggc taggcggcac ccaccgccgg gaggaggagg      480

aggagccgag aggagctgag cgagcgcgga agtagctgct gctggtggtg acaatgtcaa      540

ataacggcct agacattcaa gacaaacccc cagcccctcc gatgagaaat accagcacta      600

tgattggagc cggcagcaaa gatgctggaa ccctaaacca tggttctaaa cctctgcctc      660

caaacccaga ggagaagaaa aagaaggacc gattttaccg atccatttta cctggagata      720

aaacaaataa aaagaaagag aaagagcggc cagagatttc tctcccttca gattttgaac      780

acacaattca tgtcggtttt gatgctgtca caggggagtt tacgggaatg ccagagcagt      840

gggcccgctt gcttcagaca tcaaatatca ctaagtcgga gcagaagaaa aacccgcagg      900

ctgttctgga tgtgttggag ttttacaact cgaagaagac atccaacagc cagaaataca      960

tgagctttac agataagtca gctgaggatt acaattcttc taatgccttg aatgtgaagg     1020

ctgtgtctga gactcctgca gtgccaccag tttcagaaga tgaggatgat gatgatgatg     1080

atgctacccc accaccagtg attgctccac gcccagagca cacaaaatct gtatacacac     1140

ggtctgtgat tgaaccactt cctgtcactc caactcggga cgtggctaca tctcccattt     1200

cacctactga aaataacacc actccaccag atgctttgac ccggaatact gagaagcaga     1260

agaagaagcc taaaatgtct gatgaggaga tcttggagaa attacgaagc atagtgagtg     1320

tgggcgatcc taagaagaaa tatacacggt ttgagaagat tggacaaggt gcttcaggca     1380

ccgtgtacac agcaatggat gtggccacag gacaggaggt ggccattaag cagatgaatc     1440

ttcagcagca gcccaagaaa gagctgatta ttaatgagat cctggtcatg agggaaaaca     1500

agaacccaaa cattgtgaat tacttggaca gttacctcgt gggagatgag ctgtgggttg     1560

ttatggaata cttggctgga ggctccttga cagatgtggt gacagaaact tgcatggatg     1620

aaggccaaat tgcagctgtg tgccgtgagt gtctgcaggc tctggagttc ttgcattcga     1680

accaggtcat tcacagagac atcaagagtg acaatattct gttgggaatg gatggctctg     1740

tcaagctaac tgactttgga ttctgtgcac agataacccc agagcagagc aaacggagca     1800

ccatggtagg aaccccatac tggatggcac cagaggttgt gacacgaaag gcctatgggc     1860

ccaaggttga catctggtcc ctgggcatca tggccatcga aatgattgaa ggggagcctc     1920

catacctcaa tgaaaaccct ctgagagcct tgtacctcat tgccaccaat gggaccccag     1980

aacttcagaa cccagagaag ctgtcagcta tcttccggga ctttctgaac cgctgtctcg     2040

agatggatgt ggagaagaga ggttcagcta aagagctgct acaggtgaga aaactgaggt     2100

ttcaagtgtt tagtaacttt tccatgatag ctgcatcaat tcctgaagat tgccaagccc     2160

ctctccagcc tcactccact gattgctgca gctaaggagg caacaaagaa caatcactaa     2220

aaccacactc accccagcct cattgtgcca agccttctgt gagataaatg cacatttcag     2280

aaattccaac tcctgatgcc ctcttctcct tgccttgctt ctcccatttc ctgatctagc     2340

actcctcaag actttgatcc ttggaaaccg tgtgtccagc attgaagaga actgcaactg     2400

aatgactaat cagatgatgg ccatttctaa ataaggaatt tcctcccaat tcatggatat     2460

gagggtggtt tatgattaag ggtttatata aataaatgtt tctagtcttc cgtgtgtcaa     2520

aatcctcacc tccttcataa ccatctccca caattaattc ttgactatat aaatttatgg     2580

tttgataata ttatcaattt gtaatcaatt gagatttctt tagtgcttgc ttttctgtga     2640

ctcaactgcc cagacacctc attgtacttg aaaactggaa cagcttggga atgccatggg     2700

gtttgataat ctgccaggga catgaagagg ctcagcttcc tggaccatga ctttggctca     2760

gctgatcctg acatgggaga acaaccacat ttttctttgt gtgtgcttct agcagctgtt     2820

cgggaggacc ttgacccaat agtgttccca tgctgtttct tgtgaaatgc tctcggctat     2880

gtagcagctt ttgattccct gcatacccta ggctgctgcc cctatcctgt cccttgttta     2940

taacattgag aggttttcta gggcacatac tgagtgagag cagtgttgag aagtcgggga     3000

aaatggtgac tacttttaga gcaaggctgg gcatcagcac ctgtccagct ctacttgtgt     3060

gatgtttcag gaactcagcc cctttttctg cctaggataa ggagctgaaa gattaacttg     3120

gatcttctaa tggtccaaat cttttggtca caataaagag tctccaaatt agagactgca     3180

tgttagttct ggatggattt ggtggcctga catgataccc tgccagctgt gaggggaccc     3240

cgtttttaag atgcatggcc aagctctctg caaatggaaa tgcttacact gggtgttggg     3300

gatgtttgct acctcctgct atttttgtgg ttttggttct cccactatgg taggacccct     3360

ggccagcatt gtggcttgtc atgtcagccc cattgactac cttctcatgc tctgaggtac     3420

tactgcctct gcagcacaaa tttctatttc tgtcaataaa aggagatgaa aatattctaa     3480

aaaa                                                                  3484


<210>  927
<211>  553
<212>  PRT
<213>  Homo Sapiens

<400>  927

Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 
1               5                   10                  15      


Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly 
            20                  25                  30          


Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 
        35                  40                  45              


Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 
    50                  55                  60                  


Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 
65                  70                  75                  80  


Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 
                85                  90                  95      


Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 
            100                 105                 110         


Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 
        115                 120                 125             


Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 
    130                 135                 140                 


Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 
145                 150                 155                 160 


Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 
                165                 170                 175     


Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 
            180                 185                 190         


Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 
        195                 200                 205             


Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 
    210                 215                 220                 


Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 
225                 230                 235                 240 


Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 
                245                 250                 255     


Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 
            260                 265                 270         


Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 
        275                 280                 285             


Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 
    290                 295                 300                 


Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 
305                 310                 315                 320 


Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 
                325                 330                 335     


Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 
            340                 345                 350         


Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 
        355                 360                 365             


Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 
    370                 375                 380                 


Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 
385                 390                 395                 400 


Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 
                405                 410                 415     


Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 
            420                 425                 430         


Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp 
        435                 440                 445             


Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr 
    450                 455                 460                 


Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly 
465                 470                 475                 480 


Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp 
                485                 490                 495     


Phe Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala 
            500                 505                 510         


Lys Glu Leu Leu Gln Val Arg Lys Leu Arg Phe Gln Val Phe Ser Asn 
        515                 520                 525             


Phe Ser Met Ile Ala Ala Ser Ile Pro Glu Asp Cys Gln Ala Pro Leu 
    530                 535                 540                 


Gln Pro His Ser Thr Asp Cys Cys Ser 
545                 550             


<210>  928
<211>  5480
<212>  DNA
<213>  Homo Sapiens

<400>  928
agcttaacaa gaccatggcc tctggacccg cgatcagctc gctgtgtggt cctgagcagc       60

cacccaacat ctctgggcct tggattccta cctggccttt cttctggatg catcattttt      120

gcctttaggt atctggacca ttccccccca tggatgataa agtctttgct tcacaccctc      180

aggattacct taaaggcctg aaaagaacag aggaggagtc tgaggaggtg aattccagcc      240

gtgctcttgc aggctggctg ggcagtgtgc tggggaggag agggagcctc tggctgggcc      300

tcctccaccg ggcctggtgt gctgggaaca ccccgcattg tcccaaggcc tcagatttga      360

ctttcaaagg gaaaacagct ctcctgataa aggacaccat tggagaaact gggcatttta      420

ccaaggattt gactggaatg gcatgcttcc tttaaagatg aaagttgact tttagagcca      480

attaaagccc tttggggaat ctggcctcat accttgtcca cacagagttc ctgtacaagg      540

ttcctgacct gtgggaagcg gcacagcacc agctaggcag agacgcccca ggccatgtta      600

gagctttgag tgaggcctgg taacagggag gcgctgtcac ctactggcct tgccaatcca      660

gctccaagat gctgagcctg aagctcccca ggctgtttag catagaccag ataccccagg      720

tgttccatga gcaaggcatc ctgttcggct accgccatcc acagagttct gccactgcct      780

gcatcctcag ccttttccaa atgaccaatg agactctcaa catttggact cacttgctgc      840

ccttctggtt ctttgcatgg aggtttgtga ctgcactgta tatgacagac atcaagaatg      900

acagctactc ctggcccatg cttgtgtaca tgtgcaccag ctgcgtgtac ccacttgtgt      960

ccagctgtgc gcacaccttc agctctatgt ccaagaatgc ccggcacatt tgctacttcc     1020

tggactatgg tgccgtcaac ctcttcagcc tgggctcagc cattgcctac tctgcataca     1080

cgttcccgga tgcgctcatg tgcaccactt tccatgacta ctacgtggcc ctggctgtac     1140

tgaacaccat cctcagcaca ggcctctcct gctactccag gtttcttgaa atccagaagc     1200

ccagactctg taaggtgatt cgtgtcctcg cctttgctta tccgtacacc tgggactccc     1260

tccccatctt ctacaggcta ttcctgttcc caggggagag tgcacaaaat gaagccacct     1320

cgtaccacca gaagcacatg atcatgaccc tcctggcctc tttcttgtac tctgcacatc     1380

tgccagaacg cctagcccct ggacgctttg actacatcgg tcacagtcac cagctgtttc     1440

acgtgtgtgt gatcctggcc acgcacatgc agatggaagc catacttctg gacaagactc     1500

tgaggaagga atggctcctg gccacctcca agcccttctc tttctctcag atagctggag     1560

ccatacttct gtgcatcatc ttcagcctca gcaacataat ttatttctca gctgctctgt     1620

atcggattcc caagccagaa ttacataaaa aagaaacatg actcagacca taagcttttc     1680

atgccagatg tcaacattaa gctgcaacat cctaaccacc ataagccgga ggtggttaca     1740

gcttatcatg gcctaaaata ttcataatgg ttggtgtctt ttgaatgaat tcatgtcaaa     1800

aatgttattc agctggggaa atttctctaa atgtacactg attctgtgtg tgtgatttta     1860

aaaggagaat atggttcaag caagtccttg ttaaggcaaa ctattgatat ttcattaatt     1920

ttaaatttac ttaaaatgtg gttttaaatt ctatttaaac atttggatta agcatattac     1980

tctggagctt tgtattattc tttaaaaatg aatcttgctt catttgatga atttcatgtc     2040

acaaagcttc tctcaagagc tctcgtagtg gcctgtcaac cactttcgga gaatgagcca     2100

ggtcagtcac tgggaggacc tgtgaaagaa agttggtcac tgagtgcctt ggggactggc     2160

aaaacattcc agaatgaaga gagctgtctg gggagagccc ttcttccctt ctccacctag     2220

tgaagggaga acagaagggg agtcctctct tcccacaagt ccattctgcc ttcaaagtgt     2280

aagttctcat gtcattatgg atttggagtt tgtcagtttt tttcttaaaa gtccacagcg     2340

gggtgtcatg tgttctgtta tgttctgttt tctggttgcc agtttgatct gcaaagtatt     2400

tttcagtgca ggtaaaatgt gttaaaccat aagagttgac tgagttaatc ccaattggtt     2460

gtgctcatat gccacctttt aaaccaatgg aaattgctat atttggggat gtcatacatt     2520

tgatattgct tcagcatttc aaatatgttg caaaatttag tatccatatg cataagaagt     2580

taatcacctt gccagtgggg tggtcacata tagtgttctc aagctttact gtgaatcaga     2640

aacatccagt aagcttgtga caaatgcaga ctcctaggga aaaccagggg gttctgcttc     2700

actaggttaa atgtaggttt tgtagaggag atctgcactg gagcaagtct cccagatgat     2760

tctaatacag gagggccaga ggccaaactt gaagaactgc tggtgttaca tgttccaaaa     2820

ggcattagac ctatcagctt tgtttcgcct gatctcaagt tttagcaact caccaactaa     2880

ggcgtaacct cattttatgt tccagcgttt tctactctga atagttctaa aacactgagc     2940

attttctcat ttgttgcatt actgattaaa gttcagtatt tcatggtgtt ttcagggaac     3000

acagaaatgc ggatgcaaaa caacttttga cagaggccca tcaaacccag atctgcactt     3060

ggtaatgact taggggggct tcctcacaat gcaggatcct ctttgctgac tcaggaatac     3120

tccatatttt agactactgc ctctaccatt aactagccca gacatttgaa tggccttgta     3180

aacagctcac tgtctaatac tcgaaggaca agtaacaatt tatattggat gagagtggtc     3240

aagaaatatg atttcgttag ttttattatc tgtttacttc ctctggggaa ggcagactga     3300

taaaattata tgggctggta aatttttggt acattaattg caagctgcat gacaaaattt     3360

gtttttctgg caacaatctg acattattag tggaattcca caccaacagg gcttgtgagc     3420

ttccatttca tcttactgta acttcaattt tatggcaaaa aaaggtacaa agtttaaata     3480

cccctttcta gtaatgccaa agacatacag tgttttacat tctctccttt ataggtaaca     3540

aaataatgtt tagctcagta agtactgaaa taatgagtga ccaatttgaa ggatttttag     3600

attatttaat ctttgcttat gttgcttttt cacatgctta atgatggaaa tgaaatgtta     3660

aatcaacaaa ataagatcca gtgtttcata acatttttat aagtttggta aactttagtc     3720

ccattatata cttttgggga cagtgttata aatcagaatt ttacgacagt ttgcagaaca     3780

ctgatttgaa agcttcctat gcaaaatgag aaggggttca aatatattaa ttatcattaa     3840

gtattaaata ataggcatta gatgtctaat gtgagtataa tttcatccaa gccatctcag     3900

aaagtctaaa aggttggcag ggggtcagct gaagacctca ctggagtggg tcttaatttt     3960

taaaaagtgt ctcactacat ttaagacatg tgacacattc ccattggtaa caattgctca     4020

ccatggcatt gtctcaaaaa agactatggt ggggagggtg gcacattcct aatgggatgt     4080

acctctcccc actccccttg cttgagaagc actactcaaa aatttaccag accttacaac     4140

tgtgataaaa cttgaatgtg tatgatgaat aaggccattc agttaacttt acctcccttt     4200

acccattgaa ggggttcctt ttccattgct cagtttttag aaaataattc tcatcttttt     4260

tctaaagaaa tgaatttgtg gctggtctga aggtagtgag ttagctcaat tgattgttcg     4320

cagtcagtta tagatcaagc tccttgttct actcttcccc tcttctcact actgcacttg     4380

actagtctta aaacaaagaa agaacgaatg aatgaatgaa tctgtggctg gatgcagtgg     4440

ctcatgcctg taatcccagc actttgggag gctgaagtgg gaggactgct tgggcccaag     4500

aattcaggac cagtctgggc aacagagcca gacactgtct ctataaaaaa aagttaaaac     4560

tagctggttg tggtggtgca cacctgtggt cccagctact gtggagggtg atgtgggagg     4620

attgcttgaa cccaggagtt ggatgctgca gtgagctatg attgcgccat tgcgctccag     4680

actgggcaac agggcaagac cctgcctcaa aaaaaaaaaa aaaagaattt gtaattgttg     4740

gtaggatgtt atgggaaatt tagaggtctt ctgagtataa agtggtttaa atatttggtc     4800

tgctgaagtc tttctggaag tgttgttccc cctgctgccc cgcccagtag aaacttgctc     4860

atatgagagg ttctgaggta ggtgcggtgt agtagaatgg cattgtcaga tatgttcaag     4920

aaacccttca tttgacacta ttttgtacct tatggtaccc tttaacattt tttaattaaa     4980

aaaaatattt tttgagacag ggtcttgttc tgttgcccag gctggagtgt agtgttgcaa     5040

tcttggctca ctgcaacctc tgcctgacag gcttcagtga tctttccacc tcagcctcct     5100

gagtagctgg gactacaggt gcatgccacc aagcctggct aactttttgt agagataggg     5160

ttttgccatg ctgcccaggc tggcttagaa ttcctgaatt caagtgattt gtctgcctca     5220

ggctcccaaa gtgctgggat tacaggcatg agccacactg cacccagtcc atgctaccct     5280

ttttatatga aacacctatt aacacggtac aacaacactt caaaacatat tatttgaatt     5340

tcggcctctg attttctagt caacaatcca ttaaggcaaa gacctgtttc caaactcaga     5400

tgttctccaa cttacactaa tgtctggttt tcttgaacta tgtgagagaa aaaaataaac     5460

agaatttatt tattataaaa                                                 5480


<210>  929
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  929

Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro 
1               5                   10                  15      


Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln 
            20                  25                  30          


Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp 
    50                  55                  60                  


Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr 
65                  70                  75                  80  


Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu 
                85                  90                  95      


Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             


Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met 
    130                 135                 140                 


Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 


Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Ile Gln 
                165                 170                 175     


Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         


Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro 
        195                 200                 205             


Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met 
    210                 215                 220                 


Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu 
225                 230                 235                 240 


Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     


Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile 
            260                 265                 270         


Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys 
        275                 280                 285             


Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile 
    290                 295                 300                 


Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile 
305                 310                 315                 320 


Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
                325                 330 


<210>  930
<211>  12926
<212>  DNA
<213>  Homo Sapiens

<400>  930
gaggcccgga ggaactcgga gggggaggga gagaaaggcc gagacggagg gagccagcgg       60

cggccgaggg gctggtccag gcgcggccgc taagaggaga ccaagaggcg ggggctgcac      120

ttgacaacca gcatgccgag atggcacacc ttgggcccac cccacctcca catagcctta      180

attacaaatc agaggacagg cttagtgagc aagactggcc agcatatttc aaggtcccat      240

gttgtggggt tgatacatct caaattgagt cagaagaggc agaagtggat gtgagagaaa      300

gagagacaca gagagacaga gagccaaaga gggcaagaga cttgacttta agagactcct      360

gtactgacaa ctccatgcag ttcggaacca gaacgactac ggctgaacca gggttcatgg      420

ggacatggca aaacgctgat actaacctct tattcagaat gtcccaacag gccatccgtt      480

gcacactggt aaactgcaca tgtgaatgtt ttcagccagg gaagattaac ctgaggactt      540

gtgatcagtg taaacatggc tgggtggcac atgccttgga taagctcagc acgcagcacc      600

tgtaccaccc cacccaagtg gagattgtgc agtccaacgt cgtgtttgac atcagcagcc      660

tgatgctcta tgggacacaa gcagtgcctg tgcggctaaa gatcctgctg gaccgtctct      720

tcagcgtcct gaagcaagag gaggtactgc acatactgca cggccttggc tggactctgc      780

gggactatgt ccgaggatac atccttcagg atgctgctgg caaggtgctg gaccgctggg      840

ccatcatgtc tcgagaagag gaaatcatca cccttcagca gtttctgcgg tttggagaaa      900

ccaaatccat tgtggagctg atggcaattc aggagaaaga agggcaggcc gtggctgtac      960

catcttcaaa gacagactca gatataagga ctttcattga gagcaataat cgcaccagga     1020

gtcccagcct ccttgctcac ttagagaaca gcaatccttc cagcattcat cacttcgaaa     1080

acatcccaaa cagccttgca tttctgcttc cattccagta cataaaccct gtctcagcac     1140

cactgctagg gttgcctcca aatgggctac tgttagagca accagggttg aggctgcggg     1200

aacccagcct ttcaactcag aatgaatata atgagagcag cgaatccgaa gtttctccca     1260

caccttataa gaatgatcaa acacccaata gaaatgccct gaccagcatt actaatgtgg     1320

agcccaaaac cgagccagcc tgtgtctctc ccattcagaa ttctgcccca gtcagtgatc     1380

taaccaaaac tgaacaccca aaaagctcat tccggattca tcggatgaga aggatggggt     1440

cagcctctag gaaaggaaga gtgttctgta atgcatgtgg gaagacattc tatgacaaag     1500

gtactctcaa aattcattac aatgctgttc acctgaagat caaacatcga tgcaccattg     1560

aaggttgcaa catggtcttt agctccctcc gaagtcgtaa tcgccacagt gcaaacccca     1620

atcctcgcct tcacatgcct atgctaagga ataaccgaga taaagattta attcgggcca     1680

cctcaggagc tgccacccct gtcatagcaa gtacaaaatc aaatctggca ctcacaagcc     1740

ctggccgacc cccaatgggt tttaccactc cccctctaga ccctgtcttg caaaatcctc     1800

tccctagcca gctagtattt tctgggctaa agactgtaca accagttcct ccattttata     1860

gaagtttact cactccaggg gaaatggtga gtcctccaac ctccctccca accagtccca     1920

tcattccaac cagtggtacc atagagcagc accccccgcc accctctgag ccagtagtgc     1980

cagcagtgat gatggccacc catgagccca gtgctgacct ggcacccaag aaaaagccca     2040

ggaagtcaag catgcctgtg aagattgaga aggaaattat tgataccgcc gatgagtttg     2100

atgatgaaga tgatgacccc aatgatggtg gagctgtggt caatgacatg agccatgaca     2160

atcattgtca ctcccaagag gagatgagcc caggcatgtc tgtgaaggac ttttctaagc     2220

ataacaggac ccggtgcatt tcaaggactg aaataaggag ggccgacagc atgacttctg     2280

aagaccaaga acctgagcgg gactatgaga acgagtctga gtcttcggag cccaaactgg     2340

gcgaggaatc catggaaggg gatgagcaca ttcacagcga agtgagtgaa aaagtcctga     2400

tgaatagtga gaggcctgat gagaaccaca gtgagccctc tcaccaggac gtcatcaagg     2460

tgaaggaaga atttacagac cccacttacg acatgtttta catgagccag tatggactgt     2520

acaatggtgg gggtgccagc atggccgcct tgcatgagag ctttacatcg tctctgaatt     2580

atggcagccc tcaaaagttc tccccagaag gtgacctatg ttctagccca gaccccaaaa     2640

tctgttatgt gtgcaagaag agtttcaaaa gctcctacag tgtgaaactt cactacagga     2700

acgttcactt gaaagagatg cacgtctgca cagtggctgg ttgcaatgct gcattcccct     2760

ctcgccgaag ccgagacaga cacagtgcca acataaacct acatcgtaaa ctgttgacca     2820

aagaactcga tgacatgggc ctggactcgt cgcagccctc ccttagcaag gacctccgcg     2880

atgaattttt ggtgaagata tatggtgccc agcaccccat ggggctcgat gtcagggaag     2940

acgcctcctc tcccgcaggg actgaagact cccacctgaa cgggtatggg agaggcatgg     3000

cagaggacta catggtcctt gacttgagca ccacctccag cctccagtcc agcagcagta     3060

tccattcctc cagagaatcc gacgcaggca gcgatgaggg gattcttctc gatgacattg     3120

acggggcgag tgacagtggg gagtcggcac acaaggccga ggcccctgcc ctccctggca     3180

gcctaggggc tgaagtttca ggatctctta tgttcagcag cttgtctggg agcaatggtg     3240

ggatcatgtg caacatttgc cacaaaatgt acagcaacaa ggggaccctg agagtgcact     3300

acaaaactgt gcatttgaga gaaatgcaca agtgcaaagt cccaggttgc aatatgatgt     3360

tttcctctgt acgaagccga aatcggcaca gtcagaaccc taatctccac aaaaacattc     3420

ccttcacttc agtagattag tctcagaatg gacactacaa atgccagctc tcaccagatg     3480

gcctacgtgt ttgaactgcc atagtcagtg tgcgcttatg tacttggggt gtgtgtgtgt     3540

gtgtgtgtgt gtgtgcattt atgtatgctc tgtggctaca tatacacaca cgtatttcct     3600

tgagataaac aagataaaca ctaggtgctt ttgaattttt ttcacttccc tttatagttt     3660

tgggaaagga gtgggatctt tgatttcagg gtgaaaacag agtacccctt taaacacaca     3720

cacacacaca tgcacataca cacacacaca cacacacaca cacagtgtgc aactagcccc     3780

agttttgaca gaataattct tggtcttccc caaagagaca atttgttgta cccatgactg     3840

ttgcctgcaa aaataaaagg gaaaaaaaag aaaaaagaaa caaaaaggaa cttcttatag     3900

ttgtcttttg tgaactttaa ggttttgaaa gaatcttcaa ttaaagcatg gcagattcac     3960

ctgtaaatat ttagccttga ggggccattg atgtaaaaca attgtattga tggttgttta     4020

acttttttgt ttaattttta cagttacatc cagctgttag atatgcagga aaagatagtt     4080

tgctggctag ctctattcat ttatgttagc attaatgcac atttttaaaa aaagaaaaaa     4140

acatggtctt gtttttacta cctgttagat atagtgctaa agaggtgctg gcatgcttta     4200

cagcacagat ctgatttttt aaaatgtcct gtactagtac ataaatcccg tcatgcactt     4260

tttttcatac actacaaggg gatgtgtaat aaccatgctt cttttttatc cttaaactat     4320

tgccatactt cagtaagtgt cttttttaaa aaaaattcac ttgtataaaa atggtctggt     4380

cagtataggg cacaaatgcc aaacaaagta ttagtgttaa cacaaaactg ccaactttgc     4440

acaagtttcc agaaaagaaa atacaattag tcactcaaca taaccacagg ccaatttgtt     4500

ggccaccaga aaaccgcttt ttaaaaaaac acttggtgat tctttcaagt gccgaatgtt     4560

attagaatca acattgcatc cttcttgctt atacgttaag ttacataaaa ggaaaacaaa     4620

attatgtggt gtgaaacagc caaggcattt attcttcaga ggcaggataa tatttcagga     4680

tacaaaagcc caaattaccc gctacggaac aaagatgaat acagtaaaag agtcgaacac     4740

tcatttccaa ggccctaacc cttatccttt aaaaagaaat cctctgaact gggtcggtct     4800

gttgtatggc tgtctaattt gttgcaaatt ctgcagtcgt actataattc aggcctgttt     4860

ggtagacaaa atcaaaaggc atttaacagc agcagtactt ggaagctttg aaaacatgtg     4920

ctaaacttga atggagcaac actcctttct gaaaagccag aagaaggggg ttttaaagca     4980

ggatctctca atgttcagtg ttttgtgttt ccccacacga tttgtcagag agaaatgaaa     5040

gcaagcctga aaccaagcaa ttgagagtga gaaagaggag agagactatt ctccaaacct     5100

tttttgtttt gttttgtttc cgatgtttac acatgttgcc tgagctggtt aaccacatcg     5160

gcagcctcag ctaccacaac atactgacta aatgatgata tttactcaag ttcagtctgc     5220

agccaaaacc attagggtgt gcattgcaga ctgttttgtt gtcttttttt tttctttttt     5280

cctttttttt taagtggagg ggaaaagaag agataaacaa ggaatatttt gtcaaacagt     5340

acacaataat ttaaagagaa tgtatttctt ttttgcattt aatggcctca gacatttctt     5400

tcatcagtct aaaagttaga aatatccctt tattttaact tttatgtcgt ttccattttt     5460

catgtttttg taattatttt ttctatgttc acatcagcat tcacttccgt taaatttgcc     5520

aaaggaaact gttaatatgt ttctgttgtt attattcctg taggatttat tgtacctcac     5580

agtatttatt gtttcccaaa ataagcatca ttagttgggg attcagtatt tttgttgtga     5640

aaatttcaga aacaatagat tcttaaagat aagctagcta tgtctaggag ctttatcttt     5700

tcacctcctt cagaggatgc tatggggtcc attttaattc ttcatttgtt ctacggggag     5760

gaaagaccaa aagtatttgc agtacaaaag aaactatatc aaacactatg ttaaatgaca     5820

agtgtttatg gtaaaaagct gaggaattag taataatcgt ttttgttttc ttgtactttg     5880

aattccccaa agtcttaatt gctttatttt ggtgttgtgt taaattgaac agacagatgt     5940

tttcctttgt tttataccat ataagactct gtacagtatg tttgtgaaag attgaactag     6000

aataatgaaa gtttgtttgc aaacattttg gtcctctcag cgttctctgt gttgtgctgt     6060

tgccccatta ccaaatggtt agattcaaaa agggtgggaa aagattttta atatcccaac     6120

aaaacattat agaaactctg gcttttgcag tgtgcataga ctacatgtag ttttatgaaa     6180

ataaatacac atttttattt cagcaacttt gaaaagttac actcagttga gttactagaa     6240

ctcatcttgt acaacagcaa tgtttagtct gtttaattta atgtcaaata aaaggtcaga     6300

tagccctcgt gagtgaatta catagctgtc ggcagtcaca tcagcaaatg caccaggctt     6360

agaacaaatg tttgttactt gctgcaaacc aagctaatgt gtatagccag ttagaaaaag     6420

tccagaagta atgagattct agaagtagag tttcccttgc ttggaaacat gaatgtgttc     6480

acctgtgttt tgtcagagaa gtggcaataa gtcctggaca gctgacactt tttaagtatc     6540

tcccctattt gctactactt ttgtgcctca agtgcccagt cgttacggtg gccttctaaa     6600

tgagtaaata acattttcca atataaagcc tatttgctta aaagggacag gggagtggat     6660

ggatgtagta catgcaatgg aaaatcataa aatgtacaat tcttctgttt ccaaagtatt     6720

gctcgttctt gagtgtgtgc ctgagtgtct tgttttgact taactagaat tctagttaag     6780

atggtgatcc catggcttat ttgcaaacag gaaggataaa gagatcagcg ttttagtcat     6840

ggagctcatc tttgcccatt cctactcatt tgctttttca taggagtttt ttgttgttaa     6900

acagtttctc tcaagccaca tgcattctat gctggctgaa aattaatagt gatgtagatg     6960

ttcatccgac aagcttttcc ccatgtgatt ggttttagcc agagtttatc acaggtacaa     7020

aattaggcgg tatgactgtg catgttctct agctgatgtt gaaacttgta ctgtcttgat     7080

catttaaaac tatgtttttg taaatatcag gtttagtccg ctttcgggaa tatctgcatg     7140

ctatggaaag agagaaaaaa aggatagata atgaggaatt tggtttaaaa gtgtgataaa     7200

aatccttggc attctttgtt ctgatattaa ttgtatttaa ataagtcaac ccaatgtaac     7260

tcattccaga tcttagtcca gctgccctgt tcagcctgat gccttttaaa ggtttaaagg     7320

tgttaatgtt ttccttttca acatggcaaa cattttttaa aacctttttg gcacaatggt     7380

gccactgtcc tcatagtgtt atttctttgg tcatgaattt tcaggccctt ccagtaagag     7440

gagaaaggca cttaactggt taacagcccc attattatac attgctctaa ggaaaaaaaa     7500

aaaaaaaaaa ctttgaatat atcaagaatg ggctattcca gaggcttctc ctcaggagaa     7560

actatgcact aggttcccac caaatacaat gtgacctttt tttccccttt ctctgtacac     7620

accccagata tgtgccaagc aaatgagaat gagggccgtt gacaattaaa gcataaagaa     7680

gctagtcacc agattgagat ggacatgctg ctaactgctg acagcttgac ctgagcagtc     7740

ctaacttgta tctggtctgt tagcattggg ttagattgac taacagagta aataaaattc     7800

acctgtcata agacacgcta catctgctat catcaagaaa caaatcatcc agaagaaact     7860

ttttttcatc ctgtggtcac acccttttct taagagcttc ttttttaaaa ttatgacaaa     7920

cgaatttcat tctttaaaat cacttatctt ctcccaaact tgaagtattt aaattaggtg     7980

gttttgcttt tccctctcat tgtttatttt ttggggatgg atctaaatga gtaagatgag     8040

caataaaaga taccagaaag actggaggga tcacagtgtt ttcatcagaa ctaagtagag     8100

ggtcggttcc tgccctggtt ttggggtagc tagaaaagga aatcatgaat gcactggaaa     8160

tgttggctcg agagaaaaga ctggcatagc tctgcctcgc agtgggtgag agcgtattga     8220

tcgtagggac ctgcagagtt cctatgacca ggtgagtcgg ctctgaggaa ggggttagga     8280

aagcaagtac agctgcatga aatagctgaa gttcctttgg ggtcaggaag agccgacaat     8340

tgtggggttt tggttgcttt tgctttgttt ttgagtggga agtgttgctg gaatcccctg     8400

agaaccgaaa gatgccaggg gtcagcaagg ctatagaaaa ggccagtggt aacacctcgt     8460

tttcatccta acagaggagt aggtgcgaat ggcaccagca tggatcgttc ctttcttgat     8520

cattactcat gcttgccact gtagcaacac aacaaagcca tgattgtaat taatactagg     8580

ctaaagacct tgatcaaaat gggagctcat ttactgttct atgaggtatg taagtaactt     8640

ctcttcacat tttccctcag agataaacca cacgtggtag tcttgtttgc gttagtacta     8700

aggtcatgtt tgatctgtcc cagacgagtc gcatatttcc tgtagctgga gtgttgctca     8760

ccataaatgg tcattttcaa aaagtattgt gtaattccag ctgtacaact gaccagtgag     8820

ttatctgtca tcactgttgc ccacataccc gtccttcctt gtgtagtttc atcatcctca     8880

tccttcccac atcttgcgca aaatgatttt ctgtgctcat tcggcaataa ctatgttatt     8940

cggcatactg tctttttggc atttgttgaa aaatccaaat gcttttaatc caaaagatta     9000

atccaaatct tttttaatcc aaatgatttt aatccaaatc caaataacag gaggttaaaa     9060

aaaaaaaaaa aactaagcat ttttacatgt acactgaatt ggatcagcat tattgttcat     9120

tataatgcta tatatatttt tggagcaaca tactatagtt gtcataaaac tatctttatt     9180

cttctcctct aaagtgctgt tgtaaattca tttgaccttt actgcaggaa aaaaaaaaat     9240

cttttttata taggatatga agaccaaggc tcagtctgta acaaatagtg gaccattaca     9300

aaagaggaaa gaaaaaagcc agggctgagc agcaagaagc ttcagttcaa tttcacctcg     9360

tatctttcta ataacatact tgtcacttta ttaccttcca gtaatgtgaa cgctgctgac     9420

aagactgtca cactaacagc agacaacacc ctctctgctt cagcccagct ctcctggcta     9480

cttattgccc tggccctgaa gggacacaaa ctaatagtgt gctttccagt tcagcacttg     9540

gccatcaaat ataaaaggat gcgtaattgc ctgtttatcc ccttgtgaag gagaaattga     9600

ctacaagggc taggctttcc catcgagttc cctgatgtac acacacatcc acaatcagtc     9660

agtctctctc tctctctctc tctctctctc tctctctctc tctctctccc ctctctctct     9720

ccttccctct tattctcccc tcctaacata caagcacata cacacaccta ctgtatctgt     9780

gggaagccca aggctgcctc tcgatgccct ctccagctat taagtggaca gtaacaagat     9840

gacttcttaa ataaagggtc agtagagaga tgctgtctgt gacggcatcc tttgcttctt     9900

tgaaaactta agtgttaaca attccatctt gagagtaatg ggtgtggccc tataattaga     9960

gcaaattttc ctgcaagtca gtggcataag taagattata ttgcccccta atctgtaggg    10020

aaaagattaa aatatttttc ttccccttca aaaagtgcac atgttgtaaa ctggttacgc    10080

acagtggtca tttttttttc ttatccttgg catcaaacca tggacgtagg tgtacaaatg    10140

catctttcaa tgacccctcc aaatccatag tgtaacatga tagattaact tttgtcaaac    10200

tggactgaca atctaaaaaa gatggcgtca ggcttttgac tttaatcgtt aaaacaagga    10260

ccaccctatg agtaaaaggt aaattctcca ctttgaagaa ctttggtaag tacaagtaca    10320

gggagcttta gaaaatcgag tgatggggac caaaggtaca aaggaagaat acatgaaaat    10380

gttatattcc aaaatgccct gagcccaaag attggctgct atttttgtat attgaaatac    10440

tcaaatgatg gttggaaagt gactagttag tgactaaatg aagtgcaaga tctatcaagc    10500

gtcttctttc tgggactagg ggatgccatg cttccttcca accttcccgc agcgcatctc    10560

agagaagata gttggcccca ttacaaacag tcacatttca gtaagatatt agtcagccag    10620

gtaagacacg tgcaggtatc ggtatcatct tccatatgaa ctttagcaag gagagaacag    10680

cagcagattt agggatagac aatgtaacag gtctatgttg acaaatctgt gctaaataat    10740

ttcatgaacc agtgtgggga ctgggaagaa aagcactttg agcaaggact cttgggttcg    10800

agcaaaggca attagttgac atgatacttc ttaagttcct cagtatgtat atgttacaat    10860

cgtttatcag acatcttaat agaatcctaa ttgaaaaacc agttgccaaa attgcacaag    10920

ttctgctcgc tgatactagc tttctcccct taactctaaa ataccaggga tgcttaagga    10980

cgtttgtaat agttttttta atgctttgtt tcactttttt aaaaaagaat ctttgaaggg    11040

aaggaagagc agaaagaagt attttaagaa aaatggagag aagtagatag tattgaaagt    11100

atatttcttg aagagagagt atctaagtgc tataccaaga ttttataggg cttcctgttg    11160

ccaaatgtga tgttgagata atgcacagct aagatggcaa atccatcaat tattaactgg    11220

ctctgcccac ttctgtcatg gaatgcaagg attgagaggt gactctgggg agaccctggg    11280

tgtgtgagag agctccattc atctggccct ggatatgttt ttcaaaagag agggagaaag    11340

cgccagtccc tgcaaggtga actgacctgg cactgtttca gtgggagcct cactgcctgc    11400

cttttccatg ctaggagaca aagcatcctc taccccatct gtgaatcggt gctgtggcca    11460

ctgcgagaag catgattcat gaggtatgat gctcttgagc tcccagacaa tgtgctgagt    11520

taataggttc acttgagatg tatacaccaa ggctgtttct ttttttaaat ctagtcccca    11580

atttggagta tttttgcatg tttttgtaca gagtaatcca ttcctctcat tgtgtatctt    11640

aatctcctct gacttttcca ttgtctttct caatcccacc ctttgctctt cggatctcac    11700

caacccccct taaaaaataa atcatgtttg agcaagaagg tagaacacgc cctccctcat    11760

cttggtttta attgctttgg aaacgtgttc taccctgtcc agggtttgca taacgtgaat    11820

taagtgaatg agatgttcta gtattatatc ttaacctgat aagactatct aagatttcta    11880

gtatatggtg catttgcttt cctgtgcaaa ctttggttca gctgccctgc agagaatctc    11940

accattttcc tgccagtgcc agtataaaga atgcaggaga gctaaacctg ggtacatgaa    12000

ggtcagaggg gtgaggacgg tcgagaaatg gggagaagac ttgggcttga gacgacctgg    12060

gcttttcatg tgtagctcac tcagcagtat gaggatgact gacacaccag tgggtggttt    12120

ccaagtgagg caaatgccca tttcccctct cccctcacac cttgcctggc ttcttccatg    12180

aagtccttgc tgcttttctg cctccccaaa ggtgagggga aggggctggt tggggatctg    12240

ggaaagccag ttctctgttc tctcctgctg gtgatggact aggcctttta gaactagcaa    12300

gatccctcac acagctggga gaacacacac ctttcttact ccagacccat tggtgtgtct    12360

ccagtaacaa aattattgga ctcagcctcc atatttgaca gcaaaagtgg ccagagggag    12420

ttgaaatatc ttgaagaaaa ggaattttca ctaagatatg tcctctccct ctcccagagt    12480

ttagctgttt attccttttt tttgtttata ttgttctcat ctgcataaaa ccagtctctt    12540

gcaataagcc tgccgcagaa tcaaagtctg tacttcaaaa ggtaactgca ccaagggatg    12600

ggacagtgtg catcaccctg atctaatcat tgtgacgttg gtagcttcct aaatactgta    12660

tgtaccttga acaagggttt tatttttgtt ttgttctgtt ttgctttttg tttttattgg    12720

taggctaagg taattaaatt ttttaatttg ctgttacttt ggttgtattt tctgtactat    12780

aactgcctac agtatgtctt ttgcataaaa tgcataaggg tttggggatg taaatggaat    12840

tttattcata ttttgtccaa atacctcttg taatttgtat caaaattctt gtacaatttt    12900

tatattaaag atttatcagt cactga                                         12926


<210>  931
<211>  1099
<212>  PRT
<213>  Homo Sapiens

<400>  931

Met Ala His Leu Gly Pro Thr Pro Pro Pro His Ser Leu Asn Tyr Lys 
1               5                   10                  15      


Ser Glu Asp Arg Leu Ser Glu Gln Asp Trp Pro Ala Tyr Phe Lys Val 
            20                  25                  30          


Pro Cys Cys Gly Val Asp Thr Ser Gln Ile Glu Ser Glu Glu Ala Glu 
        35                  40                  45              


Val Asp Val Arg Glu Arg Glu Thr Gln Arg Asp Arg Glu Pro Lys Arg 
    50                  55                  60                  


Ala Arg Asp Leu Thr Leu Arg Asp Ser Cys Thr Asp Asn Ser Met Gln 
65                  70                  75                  80  


Phe Gly Thr Arg Thr Thr Thr Ala Glu Pro Gly Phe Met Gly Thr Trp 
                85                  90                  95      


Gln Asn Ala Asp Thr Asn Leu Leu Phe Arg Met Ser Gln Gln Ala Ile 
            100                 105                 110         


Arg Cys Thr Leu Val Asn Cys Thr Cys Glu Cys Phe Gln Pro Gly Lys 
        115                 120                 125             


Ile Asn Leu Arg Thr Cys Asp Gln Cys Lys His Gly Trp Val Ala His 
    130                 135                 140                 


Ala Leu Asp Lys Leu Ser Thr Gln His Leu Tyr His Pro Thr Gln Val 
145                 150                 155                 160 


Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu 
                165                 170                 175     


Tyr Gly Thr Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu Asp Arg 
            180                 185                 190         


Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu His Gly 
        195                 200                 205             


Leu Gly Trp Thr Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu Gln Asp 
    210                 215                 220                 


Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg Glu Glu 
225                 230                 235                 240 


Glu Ile Ile Thr Leu Gln Gln Phe Leu Arg Phe Gly Glu Thr Lys Ser 
                245                 250                 255     


Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala Val Ala 
            260                 265                 270         


Val Pro Ser Ser Lys Thr Asp Ser Asp Ile Arg Thr Phe Ile Glu Ser 
        275                 280                 285             


Asn Asn Arg Thr Arg Ser Pro Ser Leu Leu Ala His Leu Glu Asn Ser 
    290                 295                 300                 


Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro Leu Leu 
                325                 330                 335     


Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu Arg Leu 
            340                 345                 350         


Arg Glu Pro Ser Leu Ser Thr Gln Asn Glu Tyr Asn Glu Ser Ser Glu 
        355                 360                 365             


Ser Glu Val Ser Pro Thr Pro Tyr Lys Asn Asp Gln Thr Pro Asn Arg 
    370                 375                 380                 


Asn Ala Leu Thr Ser Ile Thr Asn Val Glu Pro Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu Thr Lys 
                405                 410                 415     


Thr Glu His Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg Arg Met 
            420                 425                 430         


Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Lys Gly Thr Leu Lys Ile His Tyr Asn Ala Val His 
    450                 455                 460                 


Leu Lys Ile Lys His Arg Cys Thr Ile Glu Gly Cys Asn Met Val Phe 
465                 470                 475                 480 


Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg 
                485                 490                 495     


Leu His Met Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu Ile Arg 
            500                 505                 510         


Ala Thr Ser Gly Ala Ala Thr Pro Val Ile Ala Ser Thr Lys Ser Asn 
        515                 520                 525             


Leu Ala Leu Thr Ser Pro Gly Arg Pro Pro Met Gly Phe Thr Thr Pro 
    530                 535                 540                 


Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val Phe 
545                 550                 555                 560 


Ser Gly Leu Lys Thr Val Gln Pro Val Pro Pro Phe Tyr Arg Ser Leu 
                565                 570                 575     


Leu Thr Pro Gly Glu Met Val Ser Pro Pro Thr Ser Leu Pro Thr Ser 
            580                 585                 590         


Pro Ile Ile Pro Thr Ser Gly Thr Ile Glu Gln His Pro Pro Pro Pro 
        595                 600                 605             


Ser Glu Pro Val Val Pro Ala Val Met Met Ala Thr His Glu Pro Ser 
    610                 615                 620                 


Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro Val 
625                 630                 635                 640 


Lys Ile Glu Lys Glu Ile Ile Asp Thr Ala Asp Glu Phe Asp Asp Glu 
                645                 650                 655     


Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser His 
            660                 665                 670         


Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser Val 
        675                 680                 685             


Lys Asp Phe Ser Lys His Asn Arg Thr Arg Cys Ile Ser Arg Thr Glu 
    690                 695                 700                 


Ile Arg Arg Ala Asp Ser Met Thr Ser Glu Asp Gln Glu Pro Glu Arg 
705                 710                 715                 720 


Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu Glu 
                725                 730                 735     


Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys Val 
            740                 745                 750         


Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser His 
        755                 760                 765             


Gln Asp Val Ile Lys Val Lys Glu Glu Phe Thr Asp Pro Thr Tyr Asp 
    770                 775                 780                 


Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ser 
785                 790                 795                 800 


Met Ala Ala Leu His Glu Ser Phe Thr Ser Ser Leu Asn Tyr Gly Ser 
                805                 810                 815     


Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro 
            820                 825                 830         


Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val 
        835                 840                 845             


Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys Thr 
    850                 855                 860                 


Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg 
865                 870                 875                 880 


His Ser Ala Asn Ile Asn Leu His Arg Lys Leu Leu Thr Lys Glu Leu 
                885                 890                 895     


Asp Asp Met Gly Leu Asp Ser Ser Gln Pro Ser Leu Ser Lys Asp Leu 
            900                 905                 910         


Arg Asp Glu Phe Leu Val Lys Ile Tyr Gly Ala Gln His Pro Met Gly 
        915                 920                 925             


Leu Asp Val Arg Glu Asp Ala Ser Ser Pro Ala Gly Thr Glu Asp Ser 
    930                 935                 940                 


His Leu Asn Gly Tyr Gly Arg Gly Met Ala Glu Asp Tyr Met Val Leu 
945                 950                 955                 960 


Asp Leu Ser Thr Thr Ser Ser Leu Gln Ser Ser Ser Ser Ile His Ser 
                965                 970                 975     


Ser Arg Glu Ser Asp Ala Gly Ser Asp Glu Gly Ile Leu Leu Asp Asp 
            980                 985                 990         


Ile Asp Gly Ala Ser Asp Ser Gly  Glu Ser Ala His Lys  Ala Glu Ala 
        995                 1000                 1005             


Pro Ala  Leu Pro Gly Ser Leu  Gly Ala Glu Val Ser  Gly Ser Leu 
    1010                 1015                 1020             


Met Phe  Ser Ser Leu Ser Gly  Ser Asn Gly Gly Ile  Met Cys Asn 
    1025                 1030                 1035             


Ile Cys  His Lys Met Tyr Ser  Asn Lys Gly Thr Leu  Arg Val His 
    1040                 1045                 1050             


Tyr Lys  Thr Val His Leu Arg  Glu Met His Lys Cys  Lys Val Pro 
    1055                 1060                 1065             


Gly Cys  Asn Met Met Phe Ser  Ser Val Arg Ser Arg  Asn Arg His 
    1070                 1075                 1080             


Ser Gln  Asn Pro Asn Leu His  Lys Asn Ile Pro Phe  Thr Ser Val 
    1085                 1090                 1095             


Asp 
    


<210>  932
<211>  2380
<212>  DNA
<213>  Homo Sapiens

<400>  932
gacttcctga tttgcaagaa ggtgcaggag ccgcagcggg cggccccggt cgcaggaact       60

gagaggcctc agctttggtg gcggctaccg gcggagacgg gggcggcggc cacgccaccg      120

ctgctgtcac agaaaggctc tggtgggtgg ggtgggaggc ggggaagtgc cgggggcgca      180

gccgacatgg gcccgccgcc acggctgctg tgagcagcct ctttccctgt gtggccgccg      240

gcgtgggcgg ggacggcgcg accctcgcgc ggccgggctg cgggcttcca ggccagcgcg      300

cgggggccgg acggacagcc ccacaccgac atgtaaccat ggactgcagg accaaggcaa      360

atccagacag aacctttgac ttggtgttga aagtgaaatg tcatgcctct gaaaatgaag      420

atcctgtggt attgtggaaa ttcccagagg actttggaga ccaggaaata ctacagagtg      480

tgccaaagtt ctgttttccc tttgacgttg aaagggtgtc tcagaatcaa gttggacagc      540

actttacctt tgtactgaca gacattgaaa gtaaacagag atttggattc tgcagactga      600

cgtcaggagg cacaatttgt ttatgcatcc ttagttacct tccctggttt gaagtgtatt      660

acaagcttct aaatactctt gcagattact tggctaagga actggaaaat gatttgaatg      720

aaactctcag atcactgtat aaccacccag taccaaaggc aaatactcct gtaaatttga      780

gtgtgaacca agagatattt attgcctgtg agcaagttct gaaagatcag cctgctctag      840

taccgcattc ctacttcatt gcccctgatg taactggact cccaacaata cccgagagta      900

gaaatcttac agaatatttt gttgccgtgg atgtgaacaa catgctgcag ctgtatgcca      960

gtatgctgca tgaaaggcgc atcgtgatta tctcgagcaa attaagcact ttaactgcct     1020

gtatccatgg atcagctgct cttctatacc caatgtattg gcaacacata tacatcccag     1080

tgcttcctcc acacctgctg gactactgct gtgccccaat gccatacctg attggaatac     1140

actccagcct catagagaga gtgaaaaaca aatcattgga agatgttgtt atgttaaatg     1200

ttgatacaaa cacattagaa tcaccattta gtgacttgaa caacctacca agtgatgtgg     1260

tctcggcctt gaaaaataaa ctgaagaagc agtctacagc tacgggtgat ggagtagcta     1320

gggcctttct tagagcacag gctgctttgt ttggatccta cagagatgca ctgagataca     1380

aacctggtga gcccatcact ttctgtgagg agagttttgt aaagcaccgc tcaagcgtga     1440

tgaaacagtt cctggaaact gccattaacc tccagctttt taagcagttt atcgatggtc     1500

gactggcaaa actaaatgca ggaaggggtt tctctgatgt atttgaagaa gagatcactt     1560

caggtggctt ttgtggaggt aaagacaagt tacaatatga ttatccattt tctcaataac     1620

aattttcttg gtctttgcac ttgtgtctga taaaacctat ttcataaaca actaatgatt     1680

tcctcctaaa tatgtaatgt cttaaataca tttttcatct tataaaagct atggaattag     1740

cttattttgc ctgatacctg ttactcaagg cattaagttg gcctcctgaa ttggcagctg     1800

ttggcctcga taatctctta atattgctgg aaattagtaa tacagaaatc caatcaactc     1860

atatcttcct gtctttcctt ctgaatagta gtattctctg ctagaaaact actagtgatg     1920

gttattactg agtatgaatt taagaactga ggttatgatt ggtaatacaa tccaaaaaga     1980

agggtctgaa caccaaaatt ctttatacat atttaagtaa ctgtattatt attatacaga     2040

tgtctttacc tttttgactt tatagatcac tgcagcatta agaaagtttc cagtttacca     2100

ttccataagt acaattaatc cttctagtgt aaatgttcaa atactgttat aattatctag     2160

gcaattaata atttacaaac tgatattttt gcacgattgt agtggtgtat agtcttgact     2220

tgcagagcat tttgcttgag tccttgaaat gtcgtgttca ttcattattt gctgagtgct     2280

tacaatgtat taggcactgt tctaaatatt aagtgtacta aataaacaaa aatccttgta     2340

ttctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           2380


<210>  933
<211>  426
<212>  PRT
<213>  Homo Sapiens

<400>  933

Met Asp Cys Arg Thr Lys Ala Asn Pro Asp Arg Thr Phe Asp Leu Val 
1               5                   10                  15      


Leu Lys Val Lys Cys His Ala Ser Glu Asn Glu Asp Pro Val Val Leu 
            20                  25                  30          


Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln Glu Ile Leu Gln Ser Val 
        35                  40                  45              


Pro Lys Phe Cys Phe Pro Phe Asp Val Glu Arg Val Ser Gln Asn Gln 
    50                  55                  60                  


Val Gly Gln His Phe Thr Phe Val Leu Thr Asp Ile Glu Ser Lys Gln 
65                  70                  75                  80  


Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly Gly Thr Ile Cys Leu Cys 
                85                  90                  95      


Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Tyr Tyr Lys Leu Leu Asn 
            100                 105                 110         


Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu Glu Asn Asp Leu Asn Glu 
        115                 120                 125             


Thr Leu Arg Ser Leu Tyr Asn His Pro Val Pro Lys Ala Asn Thr Pro 
    130                 135                 140                 


Val Asn Leu Ser Val Asn Gln Glu Ile Phe Ile Ala Cys Glu Gln Val 
145                 150                 155                 160 


Leu Lys Asp Gln Pro Ala Leu Val Pro His Ser Tyr Phe Ile Ala Pro 
                165                 170                 175     


Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu Thr Glu 
            180                 185                 190         


Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr Ala Ser 
        195                 200                 205             


Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu Ser Thr 
    210                 215                 220                 


Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro Met Tyr 
225                 230                 235                 240 


Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr 
                245                 250                 255     


Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser Leu Ile 
            260                 265                 270         


Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu Asn Val 
        275                 280                 285             


Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn Leu Pro 
    290                 295                 300                 


Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln Ser Thr 
305                 310                 315                 320 


Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln Ala Ala 
                325                 330                 335     


Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly Glu Pro 
            340                 345                 350         


Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser Val Met 
        355                 360                 365             


Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys Gln Phe 
    370                 375                 380                 


Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe Ser Asp 
385                 390                 395                 400 


Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly Lys Asp 
                405                 410                 415     


Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
            420                 425     


<210>  934
<211>  6814
<212>  DNA
<213>  Homo Sapiens

<400>  934
aggaggagga ggaggaggag aaggaggtag gggcctgcgg gtggctgggc ggggcgcgct       60

cgggcctccg ctcttcacgc gccgcattcg tagcccgaga gtccgcgccg cggggaggct      120

tggaggcaag cgctgcccgc gagctgagcc gccggaggag gagccgcggg caacgaggtt      180

tctctgtcat tcacagaaaa atgaatcatt taaacctttg gaggactcag ttatcacaat      240

acttctctac taccaactaa gatttatgat agtaaattta tgagagcaaa tttccatgtt      300

atagaactgt tgaagaacta aaagaggata ttctttcatc aaaataattc tgcagtatca      360

taatattact aaataaaatt aaaaagcaca attattaaat tattaaattt gccacacatg      420

tgcagcagct actgtatcct gatagtgacc aaacctcaaa tataaatggt ttcccttcat      480

gggaaaagcc attatatttg gaagaaacca ctgaacattg ttattaaata tattttcagc      540

taactgtcat ttaggagaat tttcatgaaa caagttctag aaagttccaa gtcccaccag      600

taagtggatt tgatattatg gcagcaactt acagacttgt ggttagtact gtgaaccact      660

acagcagcgt ggtgatagac cggcgttttg aacaagctat acattattgc actggaacct      720

gccacacctt cacacatgga attgactgca ttgtggtaca ccatagtgtt tgtgcagacc      780

tcttgcacat ccctgtgtct cagttcaaag atgcagatct gaactctatg tttctacccc      840

atgaaaatgg gctttcttcg gctgaaggag actatcccca acaggccttc acaggcatac      900

ccagggtcaa gagaggatct acatttcaga atacctacaa cttaaaggat attgcaggag      960

aagcaatcag ttttgccagt gggaaaataa aagaattttc ctttgaaaaa ctcaaaaact     1020

ctaaccatgc agcttacaga aagggaagga aagttaagtc tgactcattt aataggaggt     1080

cagttgattt ggacttgctt tgtggccatt ataacaacga tgggaacgcc ccatcctttg     1140

gtttactgcg gagttcctca gttgaggaaa aacctttgtc tcatagaaac tcactggata     1200

cgaacctgac ttccatgttt cttcaaaact tttctgaaga agacttggtt actcagattt     1260

tggaaaaaca taaaatagat aatttttctt ctgggacaga cataaagatg tgcttggaca     1320

tcttattgaa atgctccgag gatttaaaaa aatgcacaga catcataaaa caatgcataa     1380

agaaaaaatc agggagtagc atcagtgaag gaagtggtaa tgatacaatt tctagctctg     1440

aaactgtcta tatgaatgta atgaccaggt tagcatccta tctgaaaaag ttaccatttg     1500

aattcatgca gtctgggaat aatgaggctc tagatttaac agaactgatc agtaatatgc     1560

ctagcttaca actgactccc ttctccccag tgtttggcac tgaacaaccc cctaaatatg     1620

aagatgttgt ccagctctca gcttctgact ctggacgatt tcaaactatt gaattgcaaa     1680

atgacaagcc taattctagg aagatggaca ctgtacaatc cattccaaac aactccacaa     1740

attccttata taacttagag gtaaatgatc ctagaactct aaaagctgtc caggtccaat     1800

cacagtcatt aaccatgaat cctttagaaa atgtttcttc tgacgactta atggaaactc     1860

tttatattga agaagagtca gatggaaaga aagcattaga taaaggacaa aagacagaga     1920

atggacctag tcatgagtta ttaaaggtaa atgaacatag agcagaattt ccagaacatg     1980

ctactcatct taaaaaatgc cccaccccaa tgcaaaatga aattggtaag atatttgaga     2040

aatcatttgt taatctacct aaggaagact gtaaatcaaa agtttctaaa tttgaagagg     2100

gagaccagag agattttaca aattccagta gccaggaaga gatagataaa ttgttaatgg     2160

atttggaatc tttttcacag aagatggaga cctctctaag agagccactt gcgaagggta     2220

aaaactctaa ttttttaaat agtcacagtc agttgaccgg tcagaccctt gtagatcttg     2280

agcctaaatc taaagtctct tcacccatag aaaaagtctc accttcctgt ctaacaagga     2340

ttattgaaac caatggacac aaaatagagg aagaggatcg agccctctta ctgcgaatcc     2400

tggaaagcat tgaagacttt gctcaagaac tagttgaatg caaatcaagc agagggagcc     2460

tatcacaaga aaaggaaatg atgcaaattc tacaggaaac cttgacaact tcctcccagg     2520

ccaatttatc agtctgtaga agtcctgttg gtgataaagc caaagatact acttcagcag     2580

ttttgattca gcagactcca gaggtgatca agattcaaaa taaaccagaa aagaaacctg     2640

gaacaccact cccacctcca gccacctctc caagtagtcc ccgacctctc tccccggttc     2700

cccatgtgaa taatgttgtg aatgcgccat tgtccataaa cattccacgg ttctactttc     2760

ctgaaggact cccagatacc tgtagtaatc atgaacaaac tctaagcaga attgaaactg     2820

ctttcatgga tattgaagaa cagaaagcag acatttatga aatggggaaa attgcaaagg     2880

tctgtggctg tcctctctat tggaaagccc ccatgttcag ggctgcaggg ggagagaaga     2940

caggatttgt gacagcacag tcattcattg ccatgtggag aaagttgctg aataaccatc     3000

atgatgatgc ctctaaattc atctgtcttc tagcaaagcc caactgcagc tctctagaac     3060

aggaggattt catccctcta cttcaggatg tggtggatac ccaccctggt ctcacgttcc     3120

tgaaagatgc tccagaattc cactcccgct acatcaccac ggttattcag agaatattct     3180

acacagtcaa cagatcttgg agtggaaaaa ttacttcgac agagataaga aaaagcaact     3240

ttttgcaaac cctagcactt ttggaagaag aggaagatat aaaccaaatt acagattact     3300

tctcctatga acatttctat gttatttatt gtaaattctg ggaactagat actgatcacg     3360

acctctacat cagccaggcc gatctgtctc gatacaatga ccaggcttca tcaagcagga     3420

ttattgaaag gatattctct ggtgcagtaa caaggggaaa aacaatacag aaagagggaa     3480

gaatgagcta tgcagatttt gtttggtttt tgatctctga agaagacaaa aggaatccta     3540

ccagcattga gtattggttc cgctgcatgg atgtggatgg agacggtgta ctctccatgt     3600

atgagctgga gtacttctat gaggagcagt gtgaacggat ggaagccatg ggaattgagc     3660

ccttgccatt ccatgattta ctgtgccaga tgcttgacct agtgaagcca gctgttgatg     3720

gcaaaataac tctaagagat ctgaagaggt gcagaatggc tcacatcttc tatgacactt     3780

tctttaatct ggagaaatac ttagaccatg aacagagaga tccctttgcg gtccagaagg     3840

atgttgagaa cgatgggcct gagccctcag actgggaccg gtttgccgct gaggagtatg     3900

agacgcttgt tgcagaggaa tctgcccaag cacaattcca ggaaggcttt gaagattatg     3960

aaacagatga acctgcctct ccctctgaat ttggaaacaa aagcaataaa atattaagtg     4020

caagccttcc agagaaatgt ggaaagcttc aatcagtgga tgaagaatag ctgccggtgt     4080

ctacaatgaa acgaagatgt gtattttaaa tgtttctttc ttgtgaagag atgttctcgt     4140

ttgcatactg ctttttaaag actttgattt ctccaagtgt gtatcatctg cactaggaac     4200

tttgttttta agcaataggt ctggatacac atttaactta ggaggctcct ccaatttgcc     4260

tcaaacctct tacggagctt ctcctcagaa gtggtaccat cgccttccaa agtcagcact     4320

ctacactctt gaatgtacca aggatctctt ggcgacagta ccaagcacgg ttctctacac     4380

aggtgactga agttgcctct gtgttggctg gcatccctga gtcccctccg ggctcctatg     4440

gagcctagaa gaaaccttca cttgcagaaa acttgagtca gaaaattctg gaacttgaaa     4500

aagtagtaag ggcctccaga attgacttag ccctagtaat aaaagcactg ccaaaacatc     4560

tcagagactt cttttatgta tactggagtt caaagatctt taacttacct ggcttaatgt     4620

aatttcacag ttacctgcca aactactagt cactttacat cctcaggtat tgtaaccact     4680

gggccttcca actttgctgg caagctctgg taacctccct gactgtggat cttatataaa     4740

atctcaagat aaaaaaacac ttcttaaatg aagtatagaa tttgactcat acttggaaaa     4800

agccctttta acttttatct tttattcatt gaactattga atgatgtatt taatatccaa     4860

attagttgat aactgttttc acttcctatc agaaggcctg cttgaagaca taaaggaata     4920

atgatacatt aaaattctta ctagatagat atattccttc ctcccaggag tattagacta     4980

gctaatagta aaggcctcaa cgttattctt tacttcatgt tgaaaacaat tactacagat     5040

atttcatcca cctcagtatt tatcaaggaa atggaaaatg atacagctat aaaagaaagc     5100

tgttatttac tgtagttgta gatgtattca ctacagaatc ctacattttt cagcaggcca     5160

cagtccagcc aaatcctata atatccttga aaagaaacta ttaaaaagga tagacatttc     5220

tgatgtaagt aaaaccccca agcaacttaa tatccatctg tcagtcatca acttttcccc     5280

tagatttttt ttttaactag ttctgaaagt gtcaagaata gcttcccttt ccaccctacc     5340

taggttccct ccttgctggc ataaaggcca agcagtgaaa tgaaccttgg gttagagtta     5400

tggtaggcaa aaagaaaagg agaatttagg aaataaatat gctataaaca aggtacagta     5460

cagtgagagt taacaatcct aggaatcctg cctgtcacaa gctcccagtt ccctgtcatt     5520

ttatcttcat gattagaact gatcttccat ttaactatta cagaaagcag taactattgc     5580

aactatctaa tagttcacac aaaagaatta aaagcttaaa aataattttt aggaaacaca     5640

atattcaaaa tctaaacaca ctgataaatt attaagatta agattattta tgtgataaat     5700

gaaatctcct accaatccat ccagccttta ccagggaaga aaagcaatta tttcatttca     5760

gatagaaata caaaaaaaaa aaaaatactt ttcttagaag ccagatatgg tttaaatgtt     5820

ttattatcca taatgatcta aactaataag attcaccaaa aagtaaaaat tcaattttac     5880

aatatacatt ttttttttta actatttggc tttacctttt taccttggtt ctccttactg     5940

aagtcctctt gctttcactt tgatctggtt tttgaagtct cttaattatt ggctgggcat     6000

ggtgactcat gcctgtaatc ccggcacttt gggaggccaa gggaggtgat cacttgagcc     6060

caggagtaaa gaccagcctg ggcaacatag tgagactccg tctctacaaa aaataaattt     6120

agctgggcat ggtggtgcac atctgtagtc ctaccaactt gggaggctga ggcaggagaa     6180

tcgcttgagc cccaggcttc gaggctgcag tgagctatga ttacgacact gcactccagc     6240

ctaggcgaca gagcaagacc ccattctctt acaaagtctc tattataaaa gtacatccat     6300

caataccatt ccatttaaaa tgggctattg taatttaccc acattatcac attttcagga     6360

attataagaa tgtgttttat tgtactcctt ccttggagct gaatgcaagg aatgtgaatt     6420

ctgaggaatt aaggtagaat atatttgact ttctggtaaa gatcatggtt aagtataatc     6480

attactgcca aactggaatt ttcaagttat tataatatcc caggcccctt gataaaagct     6540

gagggttatc atgaccttaa tgctaattca atgagaaatg agtttaatag cataacatta     6600

ccaaggtaat caaactaata aaattccata tatcttccct gcatcttgtc actgtgtacc     6660

attcaaagtg tttataaaac tctagattca tcaaatgaga tttgctcagc tttttgaaat     6720

gttaagatgt gtttggagaa ggctgcatga ctttgttttt cccttttagc aaaactaaat     6780

aaagttgtca aatatgaatc atgttcatta aggt                                 6814


<210>  935
<211>  1150
<212>  PRT
<213>  Homo Sapiens

<400>  935

Met Ala Ala Thr Tyr Arg Leu Val Val Ser Thr Val Asn His Tyr Ser 
1               5                   10                  15      


Ser Val Val Ile Asp Arg Arg Phe Glu Gln Ala Ile His Tyr Cys Thr 
            20                  25                  30          


Gly Thr Cys His Thr Phe Thr His Gly Ile Asp Cys Ile Val Val His 
        35                  40                  45              


His Ser Val Cys Ala Asp Leu Leu His Ile Pro Val Ser Gln Phe Lys 
    50                  55                  60                  


Asp Ala Asp Leu Asn Ser Met Phe Leu Pro His Glu Asn Gly Leu Ser 
65                  70                  75                  80  


Ser Ala Glu Gly Asp Tyr Pro Gln Gln Ala Phe Thr Gly Ile Pro Arg 
                85                  90                  95      


Val Lys Arg Gly Ser Thr Phe Gln Asn Thr Tyr Asn Leu Lys Asp Ile 
            100                 105                 110         


Ala Gly Glu Ala Ile Ser Phe Ala Ser Gly Lys Ile Lys Glu Phe Ser 
        115                 120                 125             


Phe Glu Lys Leu Lys Asn Ser Asn His Ala Ala Tyr Arg Lys Gly Arg 
    130                 135                 140                 


Lys Val Lys Ser Asp Ser Phe Asn Arg Arg Ser Val Asp Leu Asp Leu 
145                 150                 155                 160 


Leu Cys Gly His Tyr Asn Asn Asp Gly Asn Ala Pro Ser Phe Gly Leu 
                165                 170                 175     


Leu Arg Ser Ser Ser Val Glu Glu Lys Pro Leu Ser His Arg Asn Ser 
            180                 185                 190         


Leu Asp Thr Asn Leu Thr Ser Met Phe Leu Gln Asn Phe Ser Glu Glu 
        195                 200                 205             


Asp Leu Val Thr Gln Ile Leu Glu Lys His Lys Ile Asp Asn Phe Ser 
    210                 215                 220                 


Ser Gly Thr Asp Ile Lys Met Cys Leu Asp Ile Leu Leu Lys Cys Ser 
225                 230                 235                 240 


Glu Asp Leu Lys Lys Cys Thr Asp Ile Ile Lys Gln Cys Ile Lys Lys 
                245                 250                 255     


Lys Ser Gly Ser Ser Ile Ser Glu Gly Ser Gly Asn Asp Thr Ile Ser 
            260                 265                 270         


Ser Ser Glu Thr Val Tyr Met Asn Val Met Thr Arg Leu Ala Ser Tyr 
        275                 280                 285             


Leu Lys Lys Leu Pro Phe Glu Phe Met Gln Ser Gly Asn Asn Glu Ala 
    290                 295                 300                 


Leu Asp Leu Thr Glu Leu Ile Ser Asn Met Pro Ser Leu Gln Leu Thr 
305                 310                 315                 320 


Pro Phe Ser Pro Val Phe Gly Thr Glu Gln Pro Pro Lys Tyr Glu Asp 
                325                 330                 335     


Val Val Gln Leu Ser Ala Ser Asp Ser Gly Arg Phe Gln Thr Ile Glu 
            340                 345                 350         


Leu Gln Asn Asp Lys Pro Asn Ser Arg Lys Met Asp Thr Val Gln Ser 
        355                 360                 365             


Ile Pro Asn Asn Ser Thr Asn Ser Leu Tyr Asn Leu Glu Val Asn Asp 
    370                 375                 380                 


Pro Arg Thr Leu Lys Ala Val Gln Val Gln Ser Gln Ser Leu Thr Met 
385                 390                 395                 400 


Asn Pro Leu Glu Asn Val Ser Ser Asp Asp Leu Met Glu Thr Leu Tyr 
                405                 410                 415     


Ile Glu Glu Glu Ser Asp Gly Lys Lys Ala Leu Asp Lys Gly Gln Lys 
            420                 425                 430         


Thr Glu Asn Gly Pro Ser His Glu Leu Leu Lys Val Asn Glu His Arg 
        435                 440                 445             


Ala Glu Phe Pro Glu His Ala Thr His Leu Lys Lys Cys Pro Thr Pro 
    450                 455                 460                 


Met Gln Asn Glu Ile Gly Lys Ile Phe Glu Lys Ser Phe Val Asn Leu 
465                 470                 475                 480 


Pro Lys Glu Asp Cys Lys Ser Lys Val Ser Lys Phe Glu Glu Gly Asp 
                485                 490                 495     


Gln Arg Asp Phe Thr Asn Ser Ser Ser Gln Glu Glu Ile Asp Lys Leu 
            500                 505                 510         


Leu Met Asp Leu Glu Ser Phe Ser Gln Lys Met Glu Thr Ser Leu Arg 
        515                 520                 525             


Glu Pro Leu Ala Lys Gly Lys Asn Ser Asn Phe Leu Asn Ser His Ser 
    530                 535                 540                 


Gln Leu Thr Gly Gln Thr Leu Val Asp Leu Glu Pro Lys Ser Lys Val 
545                 550                 555                 560 


Ser Ser Pro Ile Glu Lys Val Ser Pro Ser Cys Leu Thr Arg Ile Ile 
                565                 570                 575     


Glu Thr Asn Gly His Lys Ile Glu Glu Glu Asp Arg Ala Leu Leu Leu 
            580                 585                 590         


Arg Ile Leu Glu Ser Ile Glu Asp Phe Ala Gln Glu Leu Val Glu Cys 
        595                 600                 605             


Lys Ser Ser Arg Gly Ser Leu Ser Gln Glu Lys Glu Met Met Gln Ile 
    610                 615                 620                 


Leu Gln Glu Thr Leu Thr Thr Ser Ser Gln Ala Asn Leu Ser Val Cys 
625                 630                 635                 640 


Arg Ser Pro Val Gly Asp Lys Ala Lys Asp Thr Thr Ser Ala Val Leu 
                645                 650                 655     


Ile Gln Gln Thr Pro Glu Val Ile Lys Ile Gln Asn Lys Pro Glu Lys 
            660                 665                 670         


Lys Pro Gly Thr Pro Leu Pro Pro Pro Ala Thr Ser Pro Ser Ser Pro 
        675                 680                 685             


Arg Pro Leu Ser Pro Val Pro His Val Asn Asn Val Val Asn Ala Pro 
    690                 695                 700                 


Leu Ser Ile Asn Ile Pro Arg Phe Tyr Phe Pro Glu Gly Leu Pro Asp 
705                 710                 715                 720 


Thr Cys Ser Asn His Glu Gln Thr Leu Ser Arg Ile Glu Thr Ala Phe 
                725                 730                 735     


Met Asp Ile Glu Glu Gln Lys Ala Asp Ile Tyr Glu Met Gly Lys Ile 
            740                 745                 750         


Ala Lys Val Cys Gly Cys Pro Leu Tyr Trp Lys Ala Pro Met Phe Arg 
        755                 760                 765             


Ala Ala Gly Gly Glu Lys Thr Gly Phe Val Thr Ala Gln Ser Phe Ile 
    770                 775                 780                 


Ala Met Trp Arg Lys Leu Leu Asn Asn His His Asp Asp Ala Ser Lys 
785                 790                 795                 800 


Phe Ile Cys Leu Leu Ala Lys Pro Asn Cys Ser Ser Leu Glu Gln Glu 
                805                 810                 815     


Asp Phe Ile Pro Leu Leu Gln Asp Val Val Asp Thr His Pro Gly Leu 
            820                 825                 830         


Thr Phe Leu Lys Asp Ala Pro Glu Phe His Ser Arg Tyr Ile Thr Thr 
        835                 840                 845             


Val Ile Gln Arg Ile Phe Tyr Thr Val Asn Arg Ser Trp Ser Gly Lys 
    850                 855                 860                 


Ile Thr Ser Thr Glu Ile Arg Lys Ser Asn Phe Leu Gln Thr Leu Ala 
865                 870                 875                 880 


Leu Leu Glu Glu Glu Glu Asp Ile Asn Gln Ile Thr Asp Tyr Phe Ser 
                885                 890                 895     


Tyr Glu His Phe Tyr Val Ile Tyr Cys Lys Phe Trp Glu Leu Asp Thr 
            900                 905                 910         


Asp His Asp Leu Tyr Ile Ser Gln Ala Asp Leu Ser Arg Tyr Asn Asp 
        915                 920                 925             


Gln Ala Ser Ser Ser Arg Ile Ile Glu Arg Ile Phe Ser Gly Ala Val 
    930                 935                 940                 


Thr Arg Gly Lys Thr Ile Gln Lys Glu Gly Arg Met Ser Tyr Ala Asp 
945                 950                 955                 960 


Phe Val Trp Phe Leu Ile Ser Glu Glu Asp Lys Arg Asn Pro Thr Ser 
                965                 970                 975     


Ile Glu Tyr Trp Phe Arg Cys Met Asp Val Asp Gly Asp Gly Val Leu 
            980                 985                 990         


Ser Met Tyr Glu Leu Glu Tyr Phe  Tyr Glu Glu Gln Cys  Glu Arg Met 
        995                 1000                 1005             


Glu Ala  Met Gly Ile Glu Pro  Leu Pro Phe His Asp  Leu Leu Cys 
    1010                 1015                 1020             


Gln Met  Leu Asp Leu Val Lys  Pro Ala Val Asp Gly  Lys Ile Thr 
    1025                 1030                 1035             


Leu Arg  Asp Leu Lys Arg Cys  Arg Met Ala His Ile  Phe Tyr Asp 
    1040                 1045                 1050             


Thr Phe  Phe Asn Leu Glu Lys  Tyr Leu Asp His Glu  Gln Arg Asp 
    1055                 1060                 1065             


Pro Phe  Ala Val Gln Lys Asp  Val Glu Asn Asp Gly  Pro Glu Pro 
    1070                 1075                 1080             


Ser Asp  Trp Asp Arg Phe Ala  Ala Glu Glu Tyr Glu  Thr Leu Val 
    1085                 1090                 1095             


Ala Glu  Glu Ser Ala Gln Ala  Gln Phe Gln Glu Gly  Phe Glu Asp 
    1100                 1105                 1110             


Tyr Glu  Thr Asp Glu Pro Ala  Ser Pro Ser Glu Phe  Gly Asn Lys 
    1115                 1120                 1125             


Ser Asn  Lys Ile Leu Ser Ala  Ser Leu Pro Glu Lys  Cys Gly Lys 
    1130                 1135                 1140             


Leu Gln  Ser Val Asp Glu Glu  
    1145                 1150 


<210>  936
<211>  1665
<212>  DNA
<213>  Homo Sapiens

<400>  936
ccggaggagt cacgtagctc tgcgacatcc gcagcctcat ttaccagagg gagccagggc       60

tgcagcctca tctgtttgcg gatcagaacc cgagctgtgc ttgtggctgc ggctgctaac      120

tggctgcgca cagggagctg tcaccatgcc tcactcgtac ccagcccttt ctgctgagca      180

gaagaaggag ttgtctgaca ttgccctgcg gattgtagcc ccgggcaaag gcattctggc      240

tgcggatgag tctgtaggca gcatggccaa gcggctgagc caaattgggg tggaaaacac      300

agaggagaac cgccggctgt accgccaggt cctgttcagt gctgatgacc gtgtgaaaaa      360

gtgcattgga ggcgtcattt tcttccatga gaccctctac cagaaagatg ataatggtgt      420

tcccttcgtc cgaaccatcc aggataaggg catcgtcgtg ggcatcaagg ttgacaaggg      480

tgtggtgcct ctagctggga ctgatggaga aaccaccact caagggctgg atgggctctc      540

agaacgctgt gcccaataca agaaggatgg tgctgacttt gccaagtggc gctgtgtgct      600

gaaaatcagt gagcgtacac cctctgcact tgccattctg gagaacgcca acgtgctggc      660

ccgttatgcc agtatctgcc agcagaatgg cattgtgcct attgtggaac ctgaaatatt      720

gcctgatgga gaccacgacc tcaaacgttg tcagtatgtt acagagaagg tcttggctgc      780

tgtgtacaag gccctgagtg accatcatgt atacctggag gggaccctgc tcaagcccaa      840

catggtgacc ccgggccatg cctgtcccat caagtatacc ccagaggaga ttgccatggc      900

aactgtcact gccctgcgtc gcactgtgcc cccagctgtc ccaggagtga ccttcctgtc      960

tgggggtcag agcgaagaag aggcatcatt caacctcaat gccatcaacc gctgccccct     1020

tccccgaccc tgggcgctta ccttctccta tgggcgtgcc ctgcaagcct ctgcactcaa     1080

tgcctggcga gggcaacggg acaatgctgg ggctgccact gaggagttca tcaagcgggc     1140

tgaggtgaat gggcttgcag cccagggcaa gtatgaaggc agtggagaag atggtggagc     1200

agcagcacag tcactctaca ttgccaacca tgcctactga gtatccactc cataccacag     1260

cccttggccc agccatctgc acccactttt gcttgtagtc atggccaggg ccaaatagct     1320

atgcagagca gagatgcctt cacctggcac caacttgtct tcctttctct cttcccttcc     1380

cctctctcat tgctgcacct gggaccatag gatgggagga tagggagccc ctcatgactg     1440

agggcagaag aaattgctag aagtcagaac aggatggctg ggtctccccc tacctcttcc     1500

agctcccaca attttcccat gatgaggtag cttctccctg ggctctcctt cttgcctgcc     1560

ctgtctcctg ggatcagagg gtagtacaga agccctgact catgccttga gtacatacca     1620

tacagcaaat aaatggtagc aaaacattct aaaaaaaaaa aaaaa                     1665


<210>  937
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  937

Met Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala Leu Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly 
        35                  40                  45              


Val Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe 
    50                  55                  60                  


Ser Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg 
                85                  90                  95      


Thr Ile Gln Asp Lys Gly Ile Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Glu Arg Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Pro Ile Lys Tyr Thr Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Phe Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Arg Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Asn Ala Trp Arg Gly Gln Arg Asp Asn 
305                 310                 315                 320 


Ala Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Val Asn Gly 
                325                 330                 335     


Leu Ala Ala Gln Gly Lys Tyr Glu Gly Ser Gly Glu Asp Gly Gly Ala 
            340                 345                 350         


Ala Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr 
        355                 360                 


<210>  938
<211>  4057
<212>  DNA
<213>  Homo Sapiens

<400>  938
ccccgcctcc gcccccggct ggcgtgagct gggtgtttcc tgcctctctc agtccgggtt       60

tggagactcc tgcgtcctcc gacttttcat ggaagagatg tcaggagaaa gtgtggtgag      120

ctcagcggtg ccagcggctg ctacccgcac cacttccttc aagggcacga gccccagctc      180

caaatacgtg aagctgaatg tgggtggagc cctctactat accaccatgc agacgctgac      240

caagcaggac accatgctga aggccatgtt cagcgggcgc atggaagtgc tcaccgacag      300

tgaaggctgg atcctcattg accgctgtgg gaagcacttt ggtacgatac tcaactacct      360

tcgagacggg gcggtgcctt tacccgagag ccgccgggag atcgaggagc tgctagcaga      420

agccaagtac tacctagtcc aaggcctggt ggaagagtgc caggcggccc tacaaaacaa      480

agatacttat gagcctttct gcaaggtccc tgtgatcacc tcatccaagg aagaacaaaa      540

acttatagcg acttcaaata agccagccgt gaagttgctc tacaacagaa gtaacaacaa      600

atactcatat accagcaatt ctgacgacaa tatgttgaaa aacattgaac tgtttgataa      660

gctgtctctg cgctttaacg gaagggtcct gttcataaag gatgttattg gggatgaaat      720

ctgctgctgg tccttttatg gtcagggccg gaagattgct gaagtctgtt gtacctccat      780

cgtctatgcc actgagaaga aacagaccaa ggtggagttt cccgaagccc ggatttatga      840

ggagaccctg aacattttgc tgtatgaggc ccaggatggc cggggacctg acaatgcgct      900

cctggaggcc acaggcgggg cggcggggcg ctcccaccac ctggacgagg acgaggagcg      960

ggagcggatc gagcgcgtgc ggaggatcca catcaagcgc cctgatgacc gggcccacct     1020

ccaccagtga gcaggcaaga gaccgagccg ccctcctctc accgccccca ctccctgccg     1080

tgctacaccc agatcctgtg caggctgccg ggccccttct gcttcccttg gagcctggag     1140

atacttttgt aacaagccag atgattattt tggtattgct tgacaaggca aattgattgt     1200

cttgacccag gcgtatgacc cctgtcgttg aacaagctgt gtctaagatc tctacttttc     1260

atgagaatct gagactcttt ggagccaggc tttctcggtt ctcagaggaa aagtatgaat     1320

gagtgtgaag tgtatgtgag aacttttgtt tgcaatattt atttttgtgg gtgtcgactt     1380

cctatgtggg ctttttgggt gacactccct taagggttca gtttgacaat tctgagagtt     1440

gtcctgcagt tggaggccac cagaggtatc tgagctccct gcttcctatt tcataatcct     1500

ccagccccag caggtccact cctggttcct gtgtgtttgg cccgggcaca atccccactg     1560

ctttgctaga cgtgctttct gccatgtggc tttgggccta gagcttgttg ataattgcag     1620

cttgtggcag tggaaatatg gctgaatgag cgtctaaatc gttgagacca gtgcaacttt     1680

gggtgcaagg ctttgtttag ggatcaagcc ttttgccacc ttgggctggt ctttggcctg     1740

gtgctcactg ggaccccata tgtctgcgta ggagcagaac tttccatggc agtaagtgtc     1800

cagctctgtt tctggttctt tccccaactc cagccccgtc cagttgttct cctgattgac     1860

ccgactccac tccaggaagg ccatctgacc ctgtgacagg catagctcat aaactacccc     1920

tccctgggat cccgctcctc ttcagcctcc ttccccatga agctgggcta actttctaag     1980

tcattttgct tagaaattca gtgtggccca taccctttgt cctcccagcc tggcatccag     2040

gcagggacac cctcacacca ccagccccag ggagcttccc tgctataaac acagaccccc     2100

ttgtctttgc ctctgatttt tacacagtgt agagtggcca gcagtgaaca ggttgaggat     2160

gtgcgggtag atagataact ttgggtctgg tttgtgtctg tgttcatgtt tgtttaaggg     2220

atatgtgtga ctgtgggtgg ggacgtgtgc ttgtggggca caggtggcgg cccctgctgg     2280

agcccggctg ggcgcagcgc ctatgtagga cgggtgttct cagtgaccta cctcccaggc     2340

tcctctgcac ctgcaaagga acaggagtga gtcgtgactg acaggggtgg ttgagactag     2400

actaggtaga gtagttacca ggagatgtga atgtgcgtca ggtgatggat gggtttgtca     2460

agggaatcgt taccgtttta taccaaaggt attaacatgg gcagcctttg acacatgtat     2520

tccaaaaacg agtttatatt ttcaaacggt ttttacagct tagactttgt acttactgcc     2580

ctgcctgtga cagttgtatg ccttcatttt gtatccaaca gcaaagtcta caataaaact     2640

ttaaaacaat catgactgaa tgtcaaaatc gtgtattggg cagatgcttt ttaaactgtc     2700

gtgtgagaaa cttttatatt aggccatttg gattttatta agtgctaagg aaagagggct     2760

tacaaaatgt ttcgtaaata ttttatactg tttaagtgtt aaacaccaac cctgtctttc     2820

ttttgggttg agctttttta gaaagtcgaa gtgaatgttg gccaggaaaa tggaaaagcc     2880

attgtataaa tttttttttg aggcggagtc ttgctctatt ggccaggctg gagtgtagtg     2940

gcaccatctc cacttaccac aacttgtgcc tcctgggttc aagcgattct gctgcctcag     3000

cctcccgagt agctgggatt gcaggtaccc atcagcccat gcccagctaa ttttgtattt     3060

ttagtagaga tggggtttca ccatgttggc caggctggtc ttgaactcct gaccctgtga     3120

tccgaccacc ttggcctccc aaagtgctgg gattacaggt gtgagtcacc acacctggct     3180

gcatagtgtt ttaaatgttt gtgtgaagaa tgagtttgtg gaacaatttg atttgctgtg     3240

gcctctatgc ctaatgagct agtgtttctg gcagctctct ctacccaact ttgcacttgt     3300

agttttgagt ctttgtctct ctggaatatg aacaggttta taaaacattc catggtgaac     3360

aattctgtcg gctgcattat agccatgagt gaatagacag cattggctgg tccaagctct     3420

gttattgagt atacaaggaa ctgatttttc ttatgttagc actaagggca aaaaccaata     3480

tttataatgt aagcactatc caggtaaaac actggcccaa gatttggtaa agagatttca     3540

ttgcaatgta ataactacag ttttttacaa attggaacag ctttggtgtg tcgtaatcaa     3600

gggttttttt tgtttgtttg tttcaaataa gccatctgat tgtggtgact ggggcccatg     3660

tccaagacaa ttcctggcat attctgtcac cctcccgtgg ggcgatcact gtgtggggac     3720

cccattcccc agttaaagtg tgtctctgta ccttacaaca gcgattcagg acccaagtgt     3780

gaacaacact cagcccgccc tctggagcgt gtgctgtctt tagggcccta cccaaagtca     3840

ctgtaacagt taagtgtgtc attaaccttt ctgtctcttt gcgccataaa aaaatgctca     3900

aagttttaga tgtagccact gtatgttgta caaacgttgg cgacatgtaa aataaaagtc     3960

ataaaatgct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                              4057


<210>  939
<211>  313
<212>  PRT
<213>  Homo Sapiens

<400>  939

Met Glu Glu Met Ser Gly Glu Ser Val Val Ser Ser Ala Val Pro Ala 
1               5                   10                  15      


Ala Ala Thr Arg Thr Thr Ser Phe Lys Gly Thr Ser Pro Ser Ser Lys 
            20                  25                  30          


Tyr Val Lys Leu Asn Val Gly Gly Ala Leu Tyr Tyr Thr Thr Met Gln 
        35                  40                  45              


Thr Leu Thr Lys Gln Asp Thr Met Leu Lys Ala Met Phe Ser Gly Arg 
    50                  55                  60                  


Met Glu Val Leu Thr Asp Ser Glu Gly Trp Ile Leu Ile Asp Arg Cys 
65                  70                  75                  80  


Gly Lys His Phe Gly Thr Ile Leu Asn Tyr Leu Arg Asp Gly Ala Val 
                85                  90                  95      


Pro Leu Pro Glu Ser Arg Arg Glu Ile Glu Glu Leu Leu Ala Glu Ala 
            100                 105                 110         


Lys Tyr Tyr Leu Val Gln Gly Leu Val Glu Glu Cys Gln Ala Ala Leu 
        115                 120                 125             


Gln Asn Lys Asp Thr Tyr Glu Pro Phe Cys Lys Val Pro Val Ile Thr 
    130                 135                 140                 


Ser Ser Lys Glu Glu Gln Lys Leu Ile Ala Thr Ser Asn Lys Pro Ala 
145                 150                 155                 160 


Val Lys Leu Leu Tyr Asn Arg Ser Asn Asn Lys Tyr Ser Tyr Thr Ser 
                165                 170                 175     


Asn Ser Asp Asp Asn Met Leu Lys Asn Ile Glu Leu Phe Asp Lys Leu 
            180                 185                 190         


Ser Leu Arg Phe Asn Gly Arg Val Leu Phe Ile Lys Asp Val Ile Gly 
        195                 200                 205             


Asp Glu Ile Cys Cys Trp Ser Phe Tyr Gly Gln Gly Arg Lys Ile Ala 
    210                 215                 220                 


Glu Val Cys Cys Thr Ser Ile Val Tyr Ala Thr Glu Lys Lys Gln Thr 
225                 230                 235                 240 


Lys Val Glu Phe Pro Glu Ala Arg Ile Tyr Glu Glu Thr Leu Asn Ile 
                245                 250                 255     


Leu Leu Tyr Glu Ala Gln Asp Gly Arg Gly Pro Asp Asn Ala Leu Leu 
            260                 265                 270         


Glu Ala Thr Gly Gly Ala Ala Gly Arg Ser His His Leu Asp Glu Asp 
        275                 280                 285             


Glu Glu Arg Glu Arg Ile Glu Arg Val Arg Arg Ile His Ile Lys Arg 
    290                 295                 300                 


Pro Asp Asp Arg Ala His Leu His Gln 
305                 310             


<210>  940
<211>  2228
<212>  DNA
<213>  Homo Sapiens

<400>  940
agaaaaccac agggcgcggg gccagggcgg cggcccccag ggagttggca ggatggcaga       60

gggcaaggca ggcggcgcgg ccggcctctt cgccaagcag gtgcagaaga agtttagcag      120

ggcccaggag aaggtgctgc agaaattggg gaaagctgta gaaaccaaag atgaacgatt      180

tgaacaaagc gctagcaact tctaccaaca acaggcagaa ggccacaagc tgtacaagga      240

cctgaagaac ttccttagtg cagtcaaagt gatgcatgaa agttcaaaaa gagtgtcaga      300

aaccctgcag gagatctaca gcagcgagtg ggacggtcat gaggagctga aggccatcgt      360

atggaataat gatctccttt gggaagacta cgaggagaaa ctggctgacc aggctgtaag      420

gaccatggaa atctatgttg cccagttcag tgaaattaag gagagaattg ccaagcgggg      480

tcggaaactc gtggactatg acagtgcccg acaccacctg gaggcagtgc agaatgccaa      540

gaagaaagat gaggccaaga ctgccaaggc agaggaagag ttcaacaaag cccagactgt      600

gtttgaagat ctgaaccaag aactactaga ggagctgcct attctttata atagtcgtat      660

tggctgctat gtgaccatct tccaaaacat ttccaacttg agggatgtct tctacaggga      720

aatgagcaag ctgaaccaca atctctacga ggtgatgagc aaactggaga agcaacattc      780

caataaagtc tttgtggtga agggactgtc aagcagcagc aggcgctctt tagtcatttc      840

tcccccagtt cgaacagcta cagtctccag tcctcttacc tcacctacta gtccctctac      900

actttccttg aagagtgaga gtgaatctgt ctcagcaact gaagatctgg cacctgatgc      960

agcccaaggg gaagacaatt ctgagatcaa ggagctctta gaagaggagg aaatagagaa     1020

ggaaggatct gaagcaagct cctctgagga agatgagcct ctaccagcct gcaatggccc     1080

cgcccaggcc cagccctctc ctaccactga aagggccaag tcccaggagg aagttctccc     1140

cagctccaca actccatcac caggcggagc cctgagccct tcagggcagc cttcatcatc     1200

tgccacagaa gtagtcctcc gaacccgcac cgcaagtgaa ggatctgaac aaccaaagaa     1260

gagagcctct atccagagga cctcagcacc ccctagtagg cctcctccac ccagagccac     1320

tgcaagcccc aggccctcct cagggaacat accttccagc cctacagcct ctggaggggg     1380

ttcacccacc agccctaggg cctccttggg gactgggact gcaagtccta ggacctccct     1440

agaggtctct cctaatccag aaccaccaga gaagccagta agaactcctg aggccaaaga     1500

aaatgaaaac atccacaatc agaaccctga agaactttgt acttccccca ccttaatgac     1560

atctcaggtt gcttcagagc ctggagaggc aaagaagatg gaagacaagg aaaaggataa     1620

taagcttatc tcagctaact cctcggaggg ccaagaccag cttcaagtct ccatggtacc     1680

agaaaacaac aacctcacag cacctgaacc tcaagaagag gtatccacaa gtgaaaatcc     1740

acaactctga agagaaacta ccaagactcc tcctgcccca aacctcgcca gagaagctct     1800

tcaaccagag ggtataggtc agagggatat aagagccagc atccatccct gggttctcag     1860

taggaatgct ggtgctgtct aaagacctgg cattaatgga ggcggaggag cagccttacg     1920

ggagggatgg agggaggcag gctggggaga agagaacatt agactcaggg aatatttaat     1980

tctggtttta gcattattag aataagactt tatacattaa ctaaagtgga gctttaatca     2040

ctataaaaag caaaagtatc tatagacaca gacacttgcc tatacagaga cataaccaca     2100

cacactcaga ggatagtgaa caaatctgtc tttgacttac gacccatttt gcaagactta     2160

aagccggaag aacacatttt cagattgtta aataaagtct gattctgact aaaaaaaaaa     2220

aaaaaaaa                                                              2228


<210>  941
<211>  565
<212>  PRT
<213>  Homo Sapiens

<400>  941

Met Ala Glu Gly Lys Ala Gly Gly Ala Ala Gly Leu Phe Ala Lys Gln 
1               5                   10                  15      


Val Gln Lys Lys Phe Ser Arg Ala Gln Glu Lys Val Leu Gln Lys Leu 
            20                  25                  30          


Gly Lys Ala Val Glu Thr Lys Asp Glu Arg Phe Glu Gln Ser Ala Ser 
        35                  40                  45              


Asn Phe Tyr Gln Gln Gln Ala Glu Gly His Lys Leu Tyr Lys Asp Leu 
    50                  55                  60                  


Lys Asn Phe Leu Ser Ala Val Lys Val Met His Glu Ser Ser Lys Arg 
65                  70                  75                  80  


Val Ser Glu Thr Leu Gln Glu Ile Tyr Ser Ser Glu Trp Asp Gly His 
                85                  90                  95      


Glu Glu Leu Lys Ala Ile Val Trp Asn Asn Asp Leu Leu Trp Glu Asp 
            100                 105                 110         


Tyr Glu Glu Lys Leu Ala Asp Gln Ala Val Arg Thr Met Glu Ile Tyr 
        115                 120                 125             


Val Ala Gln Phe Ser Glu Ile Lys Glu Arg Ile Ala Lys Arg Gly Arg 
    130                 135                 140                 


Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Leu Glu Ala Val Gln 
145                 150                 155                 160 


Asn Ala Lys Lys Lys Asp Glu Ala Lys Thr Ala Lys Ala Glu Glu Glu 
                165                 170                 175     


Phe Asn Lys Ala Gln Thr Val Phe Glu Asp Leu Asn Gln Glu Leu Leu 
            180                 185                 190         


Glu Glu Leu Pro Ile Leu Tyr Asn Ser Arg Ile Gly Cys Tyr Val Thr 
        195                 200                 205             


Ile Phe Gln Asn Ile Ser Asn Leu Arg Asp Val Phe Tyr Arg Glu Met 
    210                 215                 220                 


Ser Lys Leu Asn His Asn Leu Tyr Glu Val Met Ser Lys Leu Glu Lys 
225                 230                 235                 240 


Gln His Ser Asn Lys Val Phe Val Val Lys Gly Leu Ser Ser Ser Ser 
                245                 250                 255     


Arg Arg Ser Leu Val Ile Ser Pro Pro Val Arg Thr Ala Thr Val Ser 
            260                 265                 270         


Ser Pro Leu Thr Ser Pro Thr Ser Pro Ser Thr Leu Ser Leu Lys Ser 
        275                 280                 285             


Glu Ser Glu Ser Val Ser Ala Thr Glu Asp Leu Ala Pro Asp Ala Ala 
    290                 295                 300                 


Gln Gly Glu Asp Asn Ser Glu Ile Lys Glu Leu Leu Glu Glu Glu Glu 
305                 310                 315                 320 


Ile Glu Lys Glu Gly Ser Glu Ala Ser Ser Ser Glu Glu Asp Glu Pro 
                325                 330                 335     


Leu Pro Ala Cys Asn Gly Pro Ala Gln Ala Gln Pro Ser Pro Thr Thr 
            340                 345                 350         


Glu Arg Ala Lys Ser Gln Glu Glu Val Leu Pro Ser Ser Thr Thr Pro 
        355                 360                 365             


Ser Pro Gly Gly Ala Leu Ser Pro Ser Gly Gln Pro Ser Ser Ser Ala 
    370                 375                 380                 


Thr Glu Val Val Leu Arg Thr Arg Thr Ala Ser Glu Gly Ser Glu Gln 
385                 390                 395                 400 


Pro Lys Lys Arg Ala Ser Ile Gln Arg Thr Ser Ala Pro Pro Ser Arg 
                405                 410                 415     


Pro Pro Pro Pro Arg Ala Thr Ala Ser Pro Arg Pro Ser Ser Gly Asn 
            420                 425                 430         


Ile Pro Ser Ser Pro Thr Ala Ser Gly Gly Gly Ser Pro Thr Ser Pro 
        435                 440                 445             


Arg Ala Ser Leu Gly Thr Gly Thr Ala Ser Pro Arg Thr Ser Leu Glu 
    450                 455                 460                 


Val Ser Pro Asn Pro Glu Pro Pro Glu Lys Pro Val Arg Thr Pro Glu 
465                 470                 475                 480 


Ala Lys Glu Asn Glu Asn Ile His Asn Gln Asn Pro Glu Glu Leu Cys 
                485                 490                 495     


Thr Ser Pro Thr Leu Met Thr Ser Gln Val Ala Ser Glu Pro Gly Glu 
            500                 505                 510         


Ala Lys Lys Met Glu Asp Lys Glu Lys Asp Asn Lys Leu Ile Ser Ala 
        515                 520                 525             


Asn Ser Ser Glu Gly Gln Asp Gln Leu Gln Val Ser Met Val Pro Glu 
    530                 535                 540                 


Asn Asn Asn Leu Thr Ala Pro Glu Pro Gln Glu Glu Val Ser Thr Ser 
545                 550                 555                 560 


Glu Asn Pro Gln Leu 
                565 


<210>  942
<211>  2251
<212>  DNA
<213>  Homo Sapiens

<400>  942
gacgtcacgg tcactgacag cgtgagcccg cggcggctgc tgccatggtg gctggcggcc       60

gggtaagggt ctgagtggat ctcctgccag gccagagcgc cttcgggggc cgcggcggaa      120

ggccaggagt ttgcagccag ggcgccgggt ttgtggtctg cagtgtcgtg aggctgaggt      180

gcagcatgtc tagactggga gccctgggtg gtgcccgtgc cgggctggga ctgttgctgg      240

gtaccgccgc cggccttgga ttcctgtgcc tcctttacag ccagcgatgg aaacggaccc      300

agcgtcatgg ccgcagccag agcctgccca actccctgga ctatacgcag acttcagatc      360

ccggacgcca cgtgatgctc ctgcgggctg tcccaggtgg ggctggagat gcctcagtgc      420

tgcccagcct tccacgggaa ggacaggaga aggtgctgga ccgcctggac tttgtgctga      480

ccagccttgt ggcgctgcgg cgggaggtgg aggagctgag aagcagcctg cgagggcttg      540

cgggggagat tgttggggag gtccgatgcc acatggaaga gaaccagaga gtggctcggc      600

ggcgaaggtt tccgtttgtc cgggagagga gtgactccac tggctccagc tctgtctact      660

tcacggcctc ctcgggagcc acgttcacag atgctgagag tgaagggggt tacacaacag      720

ccaatgcgga gtctgacaat gagcgggact ctgacaaaga aagtgaggac ggggaagatg      780

aagtgagctg tgagactgtg aagatgggga gaaaggattc tcttgacttg gaggaagagg      840

cagcttcagg tgcctccagt gccctggagg ctggaggttc ctcaggcttg gaggatgtgc      900

tgcccctcct gcagcaggcc gacgagctgc acaggggtga tgagcaaggc aagcgggagg      960

gcttccagct gctgctcaac aacaagctgg tgtatggaag ccggcaggac tttctctggc     1020

gcctggcccg agcctacagt gacatgtgtg agctcactga ggaggtgagc gagaagaagt     1080

catatgccct agatggaaaa gaagaagcag aggctgctct ggagaagggg gatgagagtg     1140

ctgactgtca cctgtggtat gcggtgcttt gtggtcagct ggctgagcat gagagcatcc     1200

agaggcgcat ccagagtggc tttagcttca aggagcatgt ggacaaagcc attgctctcc     1260

agccagaaaa ccccatggct cactttcttc ttggcaggtg gtgctatcag gtctctcacc     1320

tgagctggct agaaaaaaaa actgctacag ccttgcttga aagccctctc agtgccactg     1380

tggaagatgc cctccagagc ttcctaaagg ctgaagaact acagccagga ttttccaaag     1440

caggaagggt atatatttcc aagtgctaca gagaactagg gaaaaactct gaagctagat     1500

ggtggatgaa gttggccctg gagctgccag atgtcacgaa ggaggatttg gctatccaga     1560

aggacctgga agaactggaa gtcattttac gagactaacc acgtttcact ggccttcatg     1620

acttgatgcc actatttaag gtgggggggc ggggaggctt ttttccttag accttgctga     1680

gatcaggaaa ccacacaaat ctgtctcctg ggtctgactg ctacccacta ccactcccca     1740

ttagttaatt tattctaacc tctaacctaa tctagaattg gggcagtact catggcttcc     1800

gtttctgttg ttctctccct tgagtaatct cttaaaaaaa tcaagattca cacctgcccc     1860

aggattacac atgggtagag cctgcaagac ctgagacctt ccaattgctg gtgaggtgga     1920

tgaacttcaa agctatagga acaaagcaca taacttgtca ctttaatctt tttcactgac     1980

taataggact cagtacatat agtcttaaga tcatacctta cctaccaagg taaaaagagg     2040

gatcagagtg gcccacagac attgctttct tatcacctat catgtgaatt ctacctgtat     2100

tccagggctg gaccacttga taacttccag tgtcctggca gcttttggaa tgacagcagt     2160

ggtatggggt ttatgatgct ataaaacaat gtctgaaaag ttgcctagaa tatattttgt     2220

tacaaacttg aaataaacca aatttgatgt t                                    2251


<210>  943
<211>  470
<212>  PRT
<213>  Homo Sapiens

<400>  943

Met Ser Arg Leu Gly Ala Leu Gly Gly Ala Arg Ala Gly Leu Gly Leu 
1               5                   10                  15      


Leu Leu Gly Thr Ala Ala Gly Leu Gly Phe Leu Cys Leu Leu Tyr Ser 
            20                  25                  30          


Gln Arg Trp Lys Arg Thr Gln Arg His Gly Arg Ser Gln Ser Leu Pro 
        35                  40                  45              


Asn Ser Leu Asp Tyr Thr Gln Thr Ser Asp Pro Gly Arg His Val Met 
    50                  55                  60                  


Leu Leu Arg Ala Val Pro Gly Gly Ala Gly Asp Ala Ser Val Leu Pro 
65                  70                  75                  80  


Ser Leu Pro Arg Glu Gly Gln Glu Lys Val Leu Asp Arg Leu Asp Phe 
                85                  90                  95      


Val Leu Thr Ser Leu Val Ala Leu Arg Arg Glu Val Glu Glu Leu Arg 
            100                 105                 110         


Ser Ser Leu Arg Gly Leu Ala Gly Glu Ile Val Gly Glu Val Arg Cys 
        115                 120                 125             


His Met Glu Glu Asn Gln Arg Val Ala Arg Arg Arg Arg Phe Pro Phe 
    130                 135                 140                 


Val Arg Glu Arg Ser Asp Ser Thr Gly Ser Ser Ser Val Tyr Phe Thr 
145                 150                 155                 160 


Ala Ser Ser Gly Ala Thr Phe Thr Asp Ala Glu Ser Glu Gly Gly Tyr 
                165                 170                 175     


Thr Thr Ala Asn Ala Glu Ser Asp Asn Glu Arg Asp Ser Asp Lys Glu 
            180                 185                 190         


Ser Glu Asp Gly Glu Asp Glu Val Ser Cys Glu Thr Val Lys Met Gly 
        195                 200                 205             


Arg Lys Asp Ser Leu Asp Leu Glu Glu Glu Ala Ala Ser Gly Ala Ser 
    210                 215                 220                 


Ser Ala Leu Glu Ala Gly Gly Ser Ser Gly Leu Glu Asp Val Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Gln Ala Asp Glu Leu His Arg Gly Asp Glu Gln Gly Lys 
                245                 250                 255     


Arg Glu Gly Phe Gln Leu Leu Leu Asn Asn Lys Leu Val Tyr Gly Ser 
            260                 265                 270         


Arg Gln Asp Phe Leu Trp Arg Leu Ala Arg Ala Tyr Ser Asp Met Cys 
        275                 280                 285             


Glu Leu Thr Glu Glu Val Ser Glu Lys Lys Ser Tyr Ala Leu Asp Gly 
    290                 295                 300                 


Lys Glu Glu Ala Glu Ala Ala Leu Glu Lys Gly Asp Glu Ser Ala Asp 
305                 310                 315                 320 


Cys His Leu Trp Tyr Ala Val Leu Cys Gly Gln Leu Ala Glu His Glu 
                325                 330                 335     


Ser Ile Gln Arg Arg Ile Gln Ser Gly Phe Ser Phe Lys Glu His Val 
            340                 345                 350         


Asp Lys Ala Ile Ala Leu Gln Pro Glu Asn Pro Met Ala His Phe Leu 
        355                 360                 365             


Leu Gly Arg Trp Cys Tyr Gln Val Ser His Leu Ser Trp Leu Glu Lys 
    370                 375                 380                 


Lys Thr Ala Thr Ala Leu Leu Glu Ser Pro Leu Ser Ala Thr Val Glu 
385                 390                 395                 400 


Asp Ala Leu Gln Ser Phe Leu Lys Ala Glu Glu Leu Gln Pro Gly Phe 
                405                 410                 415     


Ser Lys Ala Gly Arg Val Tyr Ile Ser Lys Cys Tyr Arg Glu Leu Gly 
            420                 425                 430         


Lys Asn Ser Glu Ala Arg Trp Trp Met Lys Leu Ala Leu Glu Leu Pro 
        435                 440                 445             


Asp Val Thr Lys Glu Asp Leu Ala Ile Gln Lys Asp Leu Glu Glu Leu 
    450                 455                 460                 


Glu Val Ile Leu Arg Asp 
465                 470 


<210>  944
<211>  2416
<212>  DNA
<213>  Homo Sapiens

<400>  944
ttgcagtgct tataacttta ttctgtgtaa ttcctatcca cagtcacttc tgttcatttt       60

taatgaaaac ctattgctgt tattttctat tatgagttaa cggtgatgtg tgttttttaa      120

attttgtata cttgctctca ccctaaaata taccttaaga gacttttccc ctgtttttct      180

ttctgctttc caagactcca ggaaaaacag cttccatggc acattttgta cagggcacat      240

ctagaatgat tgccgcagaa agttctacgg agcataaaga gtgtgctgaa ccatcaacaa      300

gaaagaactt gatgaattct cttgaacaaa agataaggtg tttggaaaaa caaagaaaag      360

agctcctgga agttaaccag caatgggatc agcaatttag aagtatgaaa gagttatatg      420

aaagaaaggt agcagagctg aagacgaaac tggacgccgc ggaaagattc ctcagcacgc      480

gggagaagga tccgcatcag aggcagagaa aggacgacag gcagagagag gacgacaggc      540

agcgcgacct gacccgggac cggctgcagc gggaggagaa ggaaaaggaa cgcctaaatg      600

aagaattaca tgaattgaaa gaagagaata aacttttaaa gggaaaaaat actcttgcga      660

acaaggaaaa ggaacattac gaatgtgaaa taaaacgcct caataaggct cttcaggatg      720

ccttgaatat caagtgttca ttttccgagg actgtttgag gaagtctcga gtggaattct      780

gccatgagga gatgagaaca gaaatggaag ttctgaagca gcaggtgcaa atatacgaag      840

aagacttcaa aaaggaacga tcggatcgag agagacttaa tcaagagaaa gaggagctac      900

agcaaattaa tgaaacttcc caatcccagt tgaacaggct gaattcccag ataaaagctt      960

gtcagatgga gaaagaaaaa ctagaaaagc aattaaaaca gatgtattgc ccaccctgta     1020

actgcggctt ggttttccac ctgcaagatc catgggtacc aacaggccct ggagctgtgc     1080

agaagcaacg ggagcaccca ccagactatc agtggtatgc tcttgaccag cttccgccag     1140

atgtacaaca caaggcaaat ggtttatcct cagtaaagaa agtccatccg tagaagtaca     1200

cactaacaga gagagacaac aggcaacgag ggagcgtggc tgaggaccct cttctttgtt     1260

tatactgagg cttgtttctg ccacaaaggc acatcatcta ccctgttatt tgtgcctggt     1320

catgttttcc tttggtatga atacaggaaa aggcttctga cagctaagat cctgatcaaa     1380

ttggaggagc cagttattat acaaccaaat acaacttcca gtttccttga aatgagactt     1440

ggcagatgga tgatgcacga ctccctgaaa atctcttcag catattgctg ttggatgcac     1500

aaaaatgatt ctatgattta ggcaactcag tgtttgctgc agggatattg tatgttgatt     1560

taaagtgcat atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ttcctggggt     1620

aaaaatttct gcagttgtaa acgtttaaca ttgctcccat tcttcttcca cagggcctta     1680

gttctttagc tatttgacta catattgttg acctcagtga tcctaaacgt agaattgaag     1740

aggtgtatat acctcattaa attaaataag tggttcaatc tgaataagat ggttaattgg     1800

aagctattcc ttagacagat catttcttta agatgatgag aaattgtgcg cctgcatcac     1860

aagacttgat tatgaaagat aaagtcttgg gctgggtgca gtggctcatg cctataatcc     1920

cagcactttg ggaggctgag gcaggtggat tgctttgagg ccaggagttc tagaccagcc     1980

tggccagcat ggtgaaaccc catctctact ataaatacaa aaattagcca ggctcgtggc     2040

acacacctat aaacccagct actcaggagg cttgaggcgg gaggatcact tgagcccagg     2100

gaggcagagg ttgctgtaag ttgagatcgc cactgcactc cagcctggga aatagagtga     2160

gcaagactca gtgcccccta cccacccact ccacaccacc aaaaaaaaaa aaaaaaaaaa     2220

aaggaagaca aagtcctgat gggatgatga tggctatatg gctatgctgt gtccatatat     2280

acttacagaa atatttcaga catatggatt tatagttaaa tctgtgtttt tccttccctt     2340

ggatttgatt aattttaatg aaaaacttaa ttctgacttc tcaagccaat taaaatgaaa     2400

atggaattta ttgaaa                                                     2416


<210>  945
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  945

Met Ala His Phe Val Gln Gly Thr Ser Arg Met Ile Ala Ala Glu Ser 
1               5                   10                  15      


Ser Thr Glu His Lys Glu Cys Ala Glu Pro Ser Thr Arg Lys Asn Leu 
            20                  25                  30          


Met Asn Ser Leu Glu Gln Lys Ile Arg Cys Leu Glu Lys Gln Arg Lys 
        35                  40                  45              


Glu Leu Leu Glu Val Asn Gln Gln Trp Asp Gln Gln Phe Arg Ser Met 
    50                  55                  60                  


Lys Glu Leu Tyr Glu Arg Lys Val Ala Glu Leu Lys Thr Lys Leu Asp 
65                  70                  75                  80  


Ala Ala Glu Arg Phe Leu Ser Thr Arg Glu Lys Asp Pro His Gln Arg 
                85                  90                  95      


Gln Arg Lys Asp Asp Arg Gln Arg Glu Asp Asp Arg Gln Arg Asp Leu 
            100                 105                 110         


Thr Arg Asp Arg Leu Gln Arg Glu Glu Lys Glu Lys Glu Arg Leu Asn 
        115                 120                 125             


Glu Glu Leu His Glu Leu Lys Glu Glu Asn Lys Leu Leu Lys Gly Lys 
    130                 135                 140                 


Asn Thr Leu Ala Asn Lys Glu Lys Glu His Tyr Glu Cys Glu Ile Lys 
145                 150                 155                 160 


Arg Leu Asn Lys Ala Leu Gln Asp Ala Leu Asn Ile Lys Cys Ser Phe 
                165                 170                 175     


Ser Glu Asp Cys Leu Arg Lys Ser Arg Val Glu Phe Cys His Glu Glu 
            180                 185                 190         


Met Arg Thr Glu Met Glu Val Leu Lys Gln Gln Val Gln Ile Tyr Glu 
        195                 200                 205             


Glu Asp Phe Lys Lys Glu Arg Ser Asp Arg Glu Arg Leu Asn Gln Glu 
    210                 215                 220                 


Lys Glu Glu Leu Gln Gln Ile Asn Glu Thr Ser Gln Ser Gln Leu Asn 
225                 230                 235                 240 


Arg Leu Asn Ser Gln Ile Lys Ala Cys Gln Met Glu Lys Glu Lys Leu 
                245                 250                 255     


Glu Lys Gln Leu Lys Gln Met Tyr Cys Pro Pro Cys Asn Cys Gly Leu 
            260                 265                 270         


Val Phe His Leu Gln Asp Pro Trp Val Pro Thr Gly Pro Gly Ala Val 
        275                 280                 285             


Gln Lys Gln Arg Glu His Pro Pro Asp Tyr Gln Trp Tyr Ala Leu Asp 
    290                 295                 300                 


Gln Leu Pro Pro Asp Val Gln His Lys Ala Asn Gly Leu Ser Ser Val 
305                 310                 315                 320 


Lys Lys Val His Pro 
                325 


<210>  946
<211>  8312
<212>  DNA
<213>  Homo Sapiens

<400>  946
ggagggctgg ttaccatgga atccaccatc tgttcactcc ccaccggaat gtgattatcc       60

ttgctgggct gggaagtggg gaaagcaggg gagcctgtgc tgggtgagat tatctgcaat      120

ggaccgggtt aatgggaggc ttgctttggc tcgctggaag aacaaatgaa gggagtttta      180

cttcaaccat ttgtgacttc tggccaagag gaataaattc agcttttata aggcagcagt      240

acctgtccaa agatcgcttt agttccacct tgctccacaa gcagcacaac cacactggtt      300

ggtgagaatg tatctgaaga agaggctcag ggaataaatg ggaacaggcc agcaaaacac      360

tcagctgcaa gtccaaagcc acaagtgcct ccaaagccat tacacctgca gaattcacct      420

tcgtccaata tacaccaaac ccccaggcat aaagctttac ctagtgcaaa accaaggatg      480

gaggaaatta aacctgcctc tgcttcttgt gtctcaaaag aaaaacccag taaggtatca      540

gatctcatca gtcgctttga aggaggcagc tcattatcaa attatagtga tttgaagaaa      600

gagtctgctg tgaacctaaa tgctcctaga accccaggaa ggcatggatt gacaaccaca      660

cctcaacaaa aactcctctc ccagcacttg ccacagaggc agggaaatga tacagataag      720

actcagggtg cacagacttg tgtggccaac ggtgtaatgg cagcacaaaa ccagatggaa      780

tgtgaggagg agaaagctgc cactcttagc tcagatactt ctattcaagc ttctgaaccc      840

ttgcttgata cgcacatagt gaatggagaa agagatgaaa ctgccacagc tcctgcatca      900

cccacaacag acagctgtga tggaaatgct tctgacagta gctacaggac tccaggcata      960

ggcccagtgc tccccctaga agaaagaggg gcagaaacag aaaccaaggt acaagagagg     1020

gaaaatgggg aaagccctct ggaactggag cagctggacc agcaccatga gatgaaggag     1080

actaatgagc aaaaacttca caaaatagcc aatgaacttt tgcttactga aagagcttat     1140

gtcaaccgac ttgacctctt agatcaggta ttttattgca aactgttgga agaagcaaac     1200

cgaggctcgt ttccagcaga gatggtgaat aaaatctttt ctaatatttc atcaataaat     1260

gccttccata gtaaattcct cttgccagag ctggagaaac gaatgcaaga atgggaaact     1320

actcctagaa ttggagacat ccttcagaaa ttggcaccat tccttaagat gtatggagaa     1380

tatgtgaaag gatttgataa tgcaatggaa ttggttaaaa acatgacaga acgtattccc     1440

cagttcaaat cagtggttga agaaattcag aaacagaaaa tctgtgggag cttaactttg     1500

cagcatcaca tgctagaacc tgttcagcgg attccccggt atgagatgct ccttaaggac     1560

tatctaagga aattgcctcc tgattccctg gactggaatg atgctaaaaa atcacttgaa     1620

attatatcta cagcagcaag ccattctaat agtgcaataa ggaaaatgga gaacctaaag     1680

aaactcttag agatttatga aatgttggga gaagaagaag acattgtaaa cccttcaaat     1740

gaactaataa aagaaggaca gatcctcaaa ctagctgctc ggaacacttc agcacaagaa     1800

cgctaccttt tcttattcaa caacatgttg ctgtactgtg tgcccaaatt cagcttggta     1860

ggctctaaat tcacagttcg aaccagggtt ggcattgatg gaatgaaaat tgtagagact     1920

caaaatgaag aatatccaca tactttccag gtgtctggga aagagagaac actggaactg     1980

caggccagtt ctgcgcaaga caaagaagaa tggatcaagg cccttcaaga aaccatcgat     2040

gcttttcatc aaaggcatga aaccttcaga aatgcaattg caaaggataa tgacattcac     2100

tcagaggttt ctactgctga gctagggaaa agagccccaa gatggatccg agataatgaa     2160

gtgacaatgt gtatgaaatg taaagaacct ttcaatgcac tgacacgaag gaggcatcat     2220

tgtcgagcat gtggatatgt ggtttgttgg aaatgctccg actacaaagc tcaacttgaa     2280

tatgatggtg gtaaattgag caaagtttgt aaagactgtt atcaaatcat aagtggattc     2340

acagacagtg aagaaaagaa aagaaaagga attttagaga ttgaatcagc agaagtatct     2400

ggaaacagtg tggtgtgcag ctttcttcag tatatggaga agtcaaaacc ttggcagaaa     2460

gcttggtgtg tgatccccaa gcaagaccct cttgtgctgt acatgtatgg tgccccccag     2520

gacgtcagag cccaggccac cattccactt ctgggctatg tggtggatga aatgccaagg     2580

agcgcagacc tgccacacag tttcaaactg acccagtcta agtccgtgca cagctttgct     2640

gcagacagtg aggaactgaa gcagaagtgg ctgaaagtca tccttttagc tgtcacaggt     2700

gagacaccag gtggtccaaa tgagcatcca gccaccttgg atgatcatcc tgaacctaag     2760

aaaaaatcag aatgctgaac tcctccagga ccagccatgg tgtggaggtc tcaggactta     2820

cagctcaaga cattcccagc tcttcttaca catctgctag cactttatgt tgaaaaatat     2880

aggcccataa atgcatcttt tgaggactat tttcctatgt ttatgtactc ttagtgaaat     2940

tagtgtgcag agtcattcta ccgataaagt tttgaaataa tgtgaaaact ggagcatttt     3000

ttgagctatt ccttgaatat gtgctttttt gtcttgaaga aatggtgtat caattgattc     3060

tgtcaccgtc aggttagaat gagcacttcc atttaagaaa tcctttcatg tcttcttctc     3120

tttcacatgt aggacctgga acagtttgaa agatatacct ccatgttgcc aaaatagatc     3180

catggtgaaa aatacaggga cagttgaggc tattgtatta acttatttaa tttagtttat     3240

aaatctctag ctgcataaat gatgtctgtt cttttaaaac aaaagaaaaa ggacaaattg     3300

ttggtgttca gatttccgat ttataaagaa aagataactt gtttttgtag aaatactcct     3360

aagaatgtct taagtatata gcaattatgt atatatagta ttaaatatat atattataca     3420

tgcttttagg ttcacattca tctctaattt attttttaaa tataaagcat ggtttatcgt     3480

ggaattgagc aatgttctaa actgaagaaa tgttttggtg atttatgttt tgctgattgg     3540

catttgaggg tattgatatt tttataataa gcggtaattt atgtggcatg ggatatattt     3600

gtgaattcca acagtacttt taaagtacca ttttttgttt ctgtgcctat ttaaaacagt     3660

gcctctctta gaaggtgcta ttaatataag atgagggttc agttaatgct tcagtcttga     3720

ttattctaag attaaagtgc attttggtca ctgggacagt caaagtcata caggttattt     3780

taccgtttac aatcctataa ttattgcagt agttaacatc agcatgtaca aacattttca     3840

ccaaaaccca aactttatga gacacctgac cttttacaga actaggatat gtggaaacca     3900

catttatcgt aatgtttttc ttttccgtaa gataatcgag catggttaaa taaggtctct     3960

atataatgaa cacttaagat aactgtatgg gccttttcct ttgtcggaat gaaacaaaat     4020

ccacatgtga taacctatgt ttggggtggg ggctggtcac atgattcctt gtcatgaagg     4080

ctgctcttca ctcttttgta cttgtgatta aaatctcaca ctaagtttac tatttaactt     4140

aatccttttt ctcaaattaa accttttttt atactgtcat accccaaaca ttgtcacttt     4200

ttaatgtacc agtctgctag aaatctacaa gaatgatccc actatcttta gtatgtaagg     4260

attacacctt agatatagaa tagaatttga gactgccaca catttattca ggccttgtta     4320

ctttaagaaa tatcttattt tttccacccc aaaggagcaa gtgaaccaat tattgctgac     4380

ataataggtt cccttcctcc ataaaaggat tatcagccat gatcattaac attaaaccaa     4440

atagatggag ccaaaaagag ataaaagtag cttcttaggc cctattaaat cagggaaaga     4500

ctagaagaaa atttacattg cttctctttt ttaatggcca gcggggtatg tgtgtgatgt     4560

atactcagag tggttttttg gaaaattaaa ctgtagctat agatgatgct ttggttttct     4620

taatctcaag aaaagagaag caatggaaat acagaatgat taactgggga agaggacttt     4680

tgtaagtgtg actagaacaa tggtaatgta tgggccaatg ggaagattta taagtcagat     4740

tatttttgaa aactattttt aaaagcaaga agactacact ttccctacca aaacagaagt     4800

aacatggaca cacttaagtt ttggctcaat aaatatcaat gttatttaac ttagatcatt     4860

gaaagaatac tcatgtaaag ataatgttta ttatcatgct cttaacagtc attatcttta     4920

attttttaaa tgagaagcat taatactaga agagaatttc tggttatccg gtcaccatat     4980

tcactttcca ccccacattc ttcagctaaa cgcaaagaga agcagtgaaa cagccttacc     5040

cgcttctctc ttattaaaga atcactgatg tttttactca atgaaaggta aagtaatacc     5100

cttagccatt tattaaacaa ttcaaccaag agacctcaaa gtgtgattga tgataagaat     5160

aatcaatgcc ttttcccttc caacatactt gagcagtcat gacaacctaa aaatatcatt     5220

ggttgctttc ccattaaaac caacgttccc tgtgggtctt aattctttat tttcactcat     5280

ttggtgcttt ccaagtcatc ttttctttaa agtgcccttc ctccaaactt taaaaagtac     5340

ttccttgaca aaatttctat tcattataaa acatttcaat attttaagct taaattttgc     5400

ttttgctgaa agcctaccat ttggcgtgtt aagtatgaaa tatagtgcag acttttatct     5460

tggttttaag tggggctcaa taaaaaacac cagccacttt tgtaataatg gcatcacagt     5520

gtcatcatgt atgcaagcaa taaaactctt tagggtatgg ttttatactg aaaatttaat     5580

atgaaggccc cttcccacaa gaatatagat aattattaac tttctagatg tgatacggta     5640

attcgaattg cagagtataa ggaagggaaa tgggaagggg catcattcct tggattttaa     5700

ataactatca agaacatttt tactttaaca aagaaaatgg atagaaaaag cacattttgt     5760

tttccctgaa gtttaatttg acatcaggtt tgtgtactta tcttcactag gtgacttaac     5820

ttaccccaat ttttttaaaa attattaaac tttttacaga aactaacctt ttaaatgtac     5880

cctttcccca tatatatata cgcacacgtt tggatttttt ttttttaaga acacttgttc     5940

tagttataaa tatataaaga aaacgataaa gtttgtggta ctgcagggtt gttaaagatt     6000

ctttgatgcc ttctaaaaac ttttgtcaaa aatacttttg agttcacaat tctgttttac     6060

ttttccttgt ccttactttt tggaaacagg gtggttgctt ttatttgttt tctggttata     6120

ttcaaagcct taagttctta atctgagcat attgtctgtg ataaatttct gatgatcttt     6180

ctggactaga tacaacctga gtagcaagca ccaaccggag caagtaaact tctagggaac     6240

aagcgtcttg ggttttatag gtatctttgc tataatgcag aatagattaa tgaagatttc     6300

ctatatcata tgatatttgt gttagtgggt ctaagattaa gcacatgata tttataagct     6360

aaaattaact caaaagtcaa gaatgtctta atgttttcat tcttaaattt tgtattctcc     6420

aagaatgtat tagtatatga actgtggcca accagttcct attcttcaga ctgtattgac     6480

atctgtagtg gatcatgttg cttcttcatt cttaccaatt ttattagaat caaacttctt     6540

gttatttgca tactattatc tactatagat tctcagcttt agaaaatgac tatgatacat     6600

aaagaccact aggtcaactt aaaaaaccct ttctgtgaat ttatacatgt atgtatatat     6660

gtaaaaacac tgttgatttg caattctgtc tttccataga aatgaacttt ttctatcgaa     6720

attgtttaac ttaaatattt taacataaat tatttacatg gatctttatg tataattcat     6780

ccttatatat accccttaat cacgtagtca tgagaagata actttgcttt ctttacagaa     6840

agggcagaga ggaataagat aagaaactga aacaagcaag aatgaagaga gatgtggggg     6900

agagactgct ggtctccaga ccacagcaat gtgttttaag ataagatgaa atattttaac     6960

tgcagaaggg atataaaatc tatgtaatta catgctgatg ggatccattg cacccaggtt     7020

tttgaccttg gcctgtaaat gctagactat gatatcttgt tattcttttt ctcctttggg     7080

cttttaaaaa ataatttcat tctcagatca ttttctgtac tgtttactga ggcaaaaaaa     7140

aaaaaaatct gaagtcaatc atggtcttct actttctgga ctgagcattt ggcagaatgc     7200

agtatctttt cctgtatttt gacatgaaat agcacatggc ttctacaaga tagttttaac     7260

ttgttggggt caccgggagt tatatgatgg tcaacccctt ttcccaaaat tcattgtggt     7320

agttttagtg gaaaacgtaa atcaagaaat ctcatatcat actttaataa ataaatacca     7380

aatacatagt gacatatagg tttgggaaga aactagtctg tggggaccat tataagagaa     7440

tcacattata tattacacag tatatggata ttggaatgta tcacttgtgg ggggttctct     7500

tcattagcaa aacagtcatg tctgtctgta tataagactt tttttttttt aaccaaacta     7560

gcatttcatt ttgtgagtga caattgacat tttaaaataa gcataggccg ggcatagtgg     7620

ctcatgcctg taatcccagc ccttgggagg ccgaggtggg cagatcactt caggtcagga     7680

gtttgagacc agcctggcca acatggtgaa accctgtctc tactaaataa aaataaaaca     7740

aaataagtgt atctgggcca ggcacggtag cccatgcctg taatcccagc actttgggag     7800

gccgaggagt tcgagaccag cctggccaac atggcaaaac cctgtctcta caaaaattag     7860

ccaggtgtgg tggcacatgc ctgtaatccc agctactcgg gaggttgagg caggagaatt     7920

gcttgaaccc gggagacaga ggttgcagtg agccgagatt gcaccactgc actccggcct     7980

gggtgacaga gcaagacttc gactcaaaaa ataaaataag cgtatctgga tttttctttt     8040

gaattcttga ctgataagtt tgagaatgta tgtttttgga attttacagt tgactcaagt     8100

gtgaaagtat acacaagtaa tttttctttt ctagctatgt gaatgtaaaa tacttgcaga     8160

taatgtatat attgtgtaat atatgtatat ttggtcataa aagcagataa ttggaaacat     8220

tgtaaaatta agcactttaa ttcctattaa atattaaaca tttgtatctt gtaaataaac     8280

acatccttaa attaaaaaaa aaaaaaaaaa aa                                   8312


<210>  947
<211>  766
<212>  PRT
<213>  Homo Sapiens

<400>  947

Met Glu Glu Ile Lys Pro Ala Ser Ala Ser Cys Val Ser Lys Glu Lys 
1               5                   10                  15      


Pro Ser Lys Val Ser Asp Leu Ile Ser Arg Phe Glu Gly Gly Ser Ser 
            20                  25                  30          


Leu Ser Asn Tyr Ser Asp Leu Lys Lys Glu Ser Ala Val Asn Leu Asn 
        35                  40                  45              


Ala Pro Arg Thr Pro Gly Arg His Gly Leu Thr Thr Thr Pro Gln Gln 
    50                  55                  60                  


Lys Leu Leu Ser Gln His Leu Pro Gln Arg Gln Gly Asn Asp Thr Asp 
65                  70                  75                  80  


Lys Thr Gln Gly Ala Gln Thr Cys Val Ala Asn Gly Val Met Ala Ala 
                85                  90                  95      


Gln Asn Gln Met Glu Cys Glu Glu Glu Lys Ala Ala Thr Leu Ser Ser 
            100                 105                 110         


Asp Thr Ser Ile Gln Ala Ser Glu Pro Leu Leu Asp Thr His Ile Val 
        115                 120                 125             


Asn Gly Glu Arg Asp Glu Thr Ala Thr Ala Pro Ala Ser Pro Thr Thr 
    130                 135                 140                 


Asp Ser Cys Asp Gly Asn Ala Ser Asp Ser Ser Tyr Arg Thr Pro Gly 
145                 150                 155                 160 


Ile Gly Pro Val Leu Pro Leu Glu Glu Arg Gly Ala Glu Thr Glu Thr 
                165                 170                 175     


Lys Val Gln Glu Arg Glu Asn Gly Glu Ser Pro Leu Glu Leu Glu Gln 
            180                 185                 190         


Leu Asp Gln His His Glu Met Lys Glu Thr Asn Glu Gln Lys Leu His 
        195                 200                 205             


Lys Ile Ala Asn Glu Leu Leu Leu Thr Glu Arg Ala Tyr Val Asn Arg 
    210                 215                 220                 


Leu Asp Leu Leu Asp Gln Val Phe Tyr Cys Lys Leu Leu Glu Glu Ala 
225                 230                 235                 240 


Asn Arg Gly Ser Phe Pro Ala Glu Met Val Asn Lys Ile Phe Ser Asn 
                245                 250                 255     


Ile Ser Ser Ile Asn Ala Phe His Ser Lys Phe Leu Leu Pro Glu Leu 
            260                 265                 270         


Glu Lys Arg Met Gln Glu Trp Glu Thr Thr Pro Arg Ile Gly Asp Ile 
        275                 280                 285             


Leu Gln Lys Leu Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys 
    290                 295                 300                 


Gly Phe Asp Asn Ala Met Glu Leu Val Lys Asn Met Thr Glu Arg Ile 
305                 310                 315                 320 


Pro Gln Phe Lys Ser Val Val Glu Glu Ile Gln Lys Gln Lys Ile Cys 
                325                 330                 335     


Gly Ser Leu Thr Leu Gln His His Met Leu Glu Pro Val Gln Arg Ile 
            340                 345                 350         


Pro Arg Tyr Glu Met Leu Leu Lys Asp Tyr Leu Arg Lys Leu Pro Pro 
        355                 360                 365             


Asp Ser Leu Asp Trp Asn Asp Ala Lys Lys Ser Leu Glu Ile Ile Ser 
    370                 375                 380                 


Thr Ala Ala Ser His Ser Asn Ser Ala Ile Arg Lys Met Glu Asn Leu 
385                 390                 395                 400 


Lys Lys Leu Leu Glu Ile Tyr Glu Met Leu Gly Glu Glu Glu Asp Ile 
                405                 410                 415     


Val Asn Pro Ser Asn Glu Leu Ile Lys Glu Gly Gln Ile Leu Lys Leu 
            420                 425                 430         


Ala Ala Arg Asn Thr Ser Ala Gln Glu Arg Tyr Leu Phe Leu Phe Asn 
        435                 440                 445             


Asn Met Leu Leu Tyr Cys Val Pro Lys Phe Ser Leu Val Gly Ser Lys 
    450                 455                 460                 


Phe Thr Val Arg Thr Arg Val Gly Ile Asp Gly Met Lys Ile Val Glu 
465                 470                 475                 480 


Thr Gln Asn Glu Glu Tyr Pro His Thr Phe Gln Val Ser Gly Lys Glu 
                485                 490                 495     


Arg Thr Leu Glu Leu Gln Ala Ser Ser Ala Gln Asp Lys Glu Glu Trp 
            500                 505                 510         


Ile Lys Ala Leu Gln Glu Thr Ile Asp Ala Phe His Gln Arg His Glu 
        515                 520                 525             


Thr Phe Arg Asn Ala Ile Ala Lys Asp Asn Asp Ile His Ser Glu Val 
    530                 535                 540                 


Ser Thr Ala Glu Leu Gly Lys Arg Ala Pro Arg Trp Ile Arg Asp Asn 
545                 550                 555                 560 


Glu Val Thr Met Cys Met Lys Cys Lys Glu Pro Phe Asn Ala Leu Thr 
                565                 570                 575     


Arg Arg Arg His His Cys Arg Ala Cys Gly Tyr Val Val Cys Trp Lys 
            580                 585                 590         


Cys Ser Asp Tyr Lys Ala Gln Leu Glu Tyr Asp Gly Gly Lys Leu Ser 
        595                 600                 605             


Lys Val Cys Lys Asp Cys Tyr Gln Ile Ile Ser Gly Phe Thr Asp Ser 
    610                 615                 620                 


Glu Glu Lys Lys Arg Lys Gly Ile Leu Glu Ile Glu Ser Ala Glu Val 
625                 630                 635                 640 


Ser Gly Asn Ser Val Val Cys Ser Phe Leu Gln Tyr Met Glu Lys Ser 
                645                 650                 655     


Lys Pro Trp Gln Lys Ala Trp Cys Val Ile Pro Lys Gln Asp Pro Leu 
            660                 665                 670         


Val Leu Tyr Met Tyr Gly Ala Pro Gln Asp Val Arg Ala Gln Ala Thr 
        675                 680                 685             


Ile Pro Leu Leu Gly Tyr Val Val Asp Glu Met Pro Arg Ser Ala Asp 
    690                 695                 700                 


Leu Pro His Ser Phe Lys Leu Thr Gln Ser Lys Ser Val His Ser Phe 
705                 710                 715                 720 


Ala Ala Asp Ser Glu Glu Leu Lys Gln Lys Trp Leu Lys Val Ile Leu 
                725                 730                 735     


Leu Ala Val Thr Gly Glu Thr Pro Gly Gly Pro Asn Glu His Pro Ala 
            740                 745                 750         


Thr Leu Asp Asp His Pro Glu Pro Lys Lys Lys Ser Glu Cys 
        755                 760                 765     


<210>  948
<211>  1516
<212>  DNA
<213>  Homo Sapiens

<400>  948
gctgcagcgg ggcaggcgcg tggccgggcc gcggcgcgat gagtggggcc cgggcggcgc       60

ccggggccgc gggcaacggc gcggtccggg ggctgcgggt ggacgggctg cccccgctgc      120

caaagagctt gagcgggctg ctgcactcgg cgtcgggcgg cggcgcgtct gggggctggc      180

ggcacctgga gcggctgtac gcgcagaagt cgcgcatcca ggacgagctg agccgcgggg      240

gcccgggcgg cggcggggcc cgggcggcag cgctgcccgc caagcctccc aacctggacg      300

ccgctctggc gctgctccgc aaagagatgg ttggtctccg ccagctggac atgtccttgc      360

tctgccaact gtacagcctc tacgagtcga ttcaggagta caagggggca tgccaggcag      420

cctccagccc agactgcact tacgctctgg agaacggctt cttcgatgaa gaggaggaat      480

atttccagga gcagaactcc ctgcacgaca ggagggaccg aggccctcct cgggacttgt      540

cactgcctgt ctcctccctc tccagcagcg actggattct ggagtccatc tagagggtct      600

tgggagggat gtgactgttg ggaagccctt cctactggac acgctgtcat catttgctgc      660

ttctcttgca agaaagcacc tccgttgtgg acggtcctcg ggcacagggg atgagcgcta      720

ccagtttcat ttgtaggcag ggagttctcc gcggatgcat ggtggcagtc tgctttgatg      780

gcagcagttt ctgcttaggt gacctagagg tcctcagcag tatcctccac acctatttat      840

tgaggtgcac ctgctgggga ttcataatga gaatataaca agaggatctc ggtgaaaggc      900

cttagtgggt gttttgtgtg aggtggcttg tagctagcta cttccttaca gatggtagag      960

tattccaatc ctctttgtgt tagggttctt gcttccagtt tgggatgtat taaaaccacc     1020

atttcactgc ttcccttcct caatatgctc tgcagctttt cttgctgttt aaacctctcg     1080

cctcagcttt atttatttgt aagctgcatt actaactgcc cagtgattcg gtgaaagctt     1140

tttactgaaa aagttaacat ttctagtcat cccaatcaac tggctttttt caaccaaaat     1200

tttatatcat tctttgtcta tcagatacga gaggaaggaa gataatacga agacatgttg     1260

aatagtgaaa aaaaaaaaaa gaacacaaaa actggggcaa gccaatgtga tgtatcactc     1320

actgtaagat ggcaaatgtt ttcattttta agattccgaa tgtaaactag tgtgctagaa     1380

agcaaaccac ccgccactca aaccagtaat taccttaagc cttaatatat ttattaaaat     1440

actttatgag aacattacac tttgtaggtt aaaaatgagg ataaaatgct aaactatcaa     1500

aaaaaaaaaa aaaaaa                                                     1516


<210>  949
<211>  184
<212>  PRT
<213>  Homo Sapiens

<400>  949

Met Ser Gly Ala Arg Ala Ala Pro Gly Ala Ala Gly Asn Gly Ala Val 
1               5                   10                  15      


Arg Gly Leu Arg Val Asp Gly Leu Pro Pro Leu Pro Lys Ser Leu Ser 
            20                  25                  30          


Gly Leu Leu His Ser Ala Ser Gly Gly Gly Ala Ser Gly Gly Trp Arg 
        35                  40                  45              


His Leu Glu Arg Leu Tyr Ala Gln Lys Ser Arg Ile Gln Asp Glu Leu 
    50                  55                  60                  


Ser Arg Gly Gly Pro Gly Gly Gly Gly Ala Arg Ala Ala Ala Leu Pro 
65                  70                  75                  80  


Ala Lys Pro Pro Asn Leu Asp Ala Ala Leu Ala Leu Leu Arg Lys Glu 
                85                  90                  95      


Met Val Gly Leu Arg Gln Leu Asp Met Ser Leu Leu Cys Gln Leu Tyr 
            100                 105                 110         


Ser Leu Tyr Glu Ser Ile Gln Glu Tyr Lys Gly Ala Cys Gln Ala Ala 
        115                 120                 125             


Ser Ser Pro Asp Cys Thr Tyr Ala Leu Glu Asn Gly Phe Phe Asp Glu 
    130                 135                 140                 


Glu Glu Glu Tyr Phe Gln Glu Gln Asn Ser Leu His Asp Arg Arg Asp 
145                 150                 155                 160 


Arg Gly Pro Pro Arg Asp Leu Ser Leu Pro Val Ser Ser Leu Ser Ser 
                165                 170                 175     


Ser Asp Trp Ile Leu Glu Ser Ile 
            180                 


<210>  950
<211>  2591
<212>  DNA
<213>  Homo Sapiens

<400>  950
gctgagcgcg ggcgcggggc cgctacgtgc gcggggagcg cggggagcgc ggggagcgcg       60

gggctgcgct cgtgtgcgct cctgggcgct cgccgccgcc gctgccgccg cgcgcctttg      120

agtcagcaaa ctccgcggcc cgcaagcccg gctcggcccg gccctgctct gttctgcccg      180

gaggagccgc ccattgatcg tgtcctgtgc tgaagatgtt tccggaacaa cagaaagagg      240

aatttgtaag tgtctgggtt cgagatccta ggattcagaa ggaggacttc tggcattctt      300

acattgacta tgagatatgt attcatacta atagcatgtg ttttacaatg aaaacatcct      360

gtgtacgaag aagatataga gaattcgtgt ggctgaggca gagactccaa agtaatgcgt      420

tgctggtaca actgccagaa cttccatcta aaaacctgtt tttcaacatg aacaatcgcc      480

agcacgtgga tcagcgtcgc cagggtctgg aagatttcct cagaaaagtc ctacagaatg      540

cacttttgct ttcagatagc agccttcacc tcttcttaca gagccatctg aattcagaag      600

acattgaggc gtgtgtttct gggcagacta agtactctgt ggaagaagca attcacaagt      660

ttgccttaat gaatagacgt ttccctgaag aagatgaaga aggaaaaaaa gaaaatgata      720

tagattatga ttcagaaagt tcatcctctg ggcttggaca cagtagtgat gacagcagtt      780

cacatggatg taaagtaaat acagctccgc aggaatcctg aaaaataatt ctaatgttac      840

tatcttagga atagcaaatt atgtccagtc atagagaaga aagcttcata ataatacatt      900

cttacctaaa gctcactgtc atgatgttag gtatttaaat tcttaaagat gttgggttgt      960

ttattagtgg tatttttatg ttgtcttatt ttaggtaagc ttctgtgtaa agctaaaaat     1020

cctgtgaata caatactatc ctttacaggc agacattatt ggtaaacaag atcttgccct     1080

ccaatgaaat gacttacatg ttttaaaaaa ccgagttggt tttattgaat ttaaaaagat     1140

aggtaactaa gtagcattta aaatcaagat agagcattcc ttcttgtatc agtggggcag     1200

tgttaccata aacacggtgt atatgttgtt aaaccctatg aagagtaaca gtgtagacca     1260

gactgcctct ctcagatatg tgcctgatat tttgtggata cctcccctgc actggcaaaa     1320

cactatgctt ttgggtgtta gactgaaata ttttaagagt atttaacctt tccagtattc     1380

tgtttcacgc ttagatggaa atgtatctta tgaatagaga catattaaaa taatgtttac     1440

atcttagaaa aaacatagat agtgctagta atattactta taactgtaat atatagattc     1500

agaaatacat tttcattatc caaaatcagc ttcaacaaat ggtttctgga gacaaataat     1560

ttgttttcat tatcattgta taatcaggtt aatgatttat tttttgacta aatgtgcaat     1620

ttcttatcac tagataactt tcagtatcag tggtggttac ttattactta aatcagagga     1680

aggattttat aaagattaat aaatttaatt ttaccaataa atattcccat aatttagaaa     1740

aggatgtcga cttgctaatt tcagaaataa ttattcattt ttaaaaagcc ccttttaaag     1800

catctacttg aagattggta taattttcat aaaatgtctt tttttttagt gtcccaaaga     1860

tatcttagat aaactatttt gaagttcaga tttcagatga ggcaacattt tcttgagata     1920

attacccaag tttcatccat gttgaatggt acaaaatatt tctgtgaaac taacaggaag     1980

atattttcag ataactagga taacttgttg ctttgttacc cagcctaatt gaagagtggc     2040

agaggctact acaaaaagca accttttcat tttcactaag agtttaaaag ctattgtatt     2100

attaaaaagt ctttacaatg cttgtttcaa agaaccaaca gaaaaaaaag ctaagaaaac     2160

tgagaactaa cattaaaaaa attaaattta gaataagaat gatttcttta atttgtcctt     2220

tttttctttg gtctaaaaca ttattaaatt tttgtaaata ttttgattta atgtgtctta     2280

gatcctcatt attttaatac aggaaaagaa aagatttagt aatttcttac catgctaata     2340

tgtaaagttc atgccatcca ggcatttaag agcgatcctc atcccttcag caatatgtat     2400

ttgagttcac actatttctg ttttacagca gttttgaaaa acacatacta tgccaccaat     2460

tgtcatatta tttttagatg atgtaacata gccatcaaaa ttaatattat gtaatgccta     2520

atacttagta tgtaaatgtc acgagatcat ttttacatta aacgtgaaaa aaaatcaaaa     2580

aaaaaaaaaa a                                                          2591


<210>  951
<211>  201
<212>  PRT
<213>  Homo Sapiens

<400>  951

Met Phe Pro Glu Gln Gln Lys Glu Glu Phe Val Ser Val Trp Val Arg 
1               5                   10                  15      


Asp Pro Arg Ile Gln Lys Glu Asp Phe Trp His Ser Tyr Ile Asp Tyr 
            20                  25                  30          


Glu Ile Cys Ile His Thr Asn Ser Met Cys Phe Thr Met Lys Thr Ser 
        35                  40                  45              


Cys Val Arg Arg Arg Tyr Arg Glu Phe Val Trp Leu Arg Gln Arg Leu 
    50                  55                  60                  


Gln Ser Asn Ala Leu Leu Val Gln Leu Pro Glu Leu Pro Ser Lys Asn 
65                  70                  75                  80  


Leu Phe Phe Asn Met Asn Asn Arg Gln His Val Asp Gln Arg Arg Gln 
                85                  90                  95      


Gly Leu Glu Asp Phe Leu Arg Lys Val Leu Gln Asn Ala Leu Leu Leu 
            100                 105                 110         


Ser Asp Ser Ser Leu His Leu Phe Leu Gln Ser His Leu Asn Ser Glu 
        115                 120                 125             


Asp Ile Glu Ala Cys Val Ser Gly Gln Thr Lys Tyr Ser Val Glu Glu 
    130                 135                 140                 


Ala Ile His Lys Phe Ala Leu Met Asn Arg Arg Phe Pro Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Gly Lys Lys Glu Asn Asp Ile Asp Tyr Asp Ser Glu Ser Ser 
                165                 170                 175     


Ser Ser Gly Leu Gly His Ser Ser Asp Asp Ser Ser Ser His Gly Cys 
            180                 185                 190         


Lys Val Asn Thr Ala Pro Gln Glu Ser 
        195                 200     


<210>  952
<211>  2559
<212>  DNA
<213>  Homo Sapiens

<400>  952
tttttttaag agacagggtc ttgctatatt gcccaggcta gtttttacat ctttaaagct       60

gaatacttag ctgggtgtgg tggtgcacat gcctgtggtc ctagctgttc aaaaggttaa      120

ggcaggaaga ttatttgagc ctaggagttc tgggctctag tgcactatgc tgactgggtg      180

tccacattaa gttcagcatc agtgtagtaa actccaagga gctgggagcc accaggttac      240

ccagggaggg gtgaactagc ccaggttaga aatggagcag gtcaaaactc ccatgctgat      300

cagtagtggg atcatacctg tgaatagtct ctgcactcca gcgtggacaa catagtgaga      360

cctcatcact ttaagaaaaa caaaccctga atattttaag ttagagatgg agttagaaat      420

acttttagtt atagcagaat catgtcaatt tttagtacat cttttactta gctttttgca      480

cacttttttt tttttgagac ggagtctcgc cctgtcccct aggctggagt gcagtggcac      540

agtcttggct cgccgcaacc tccgtctccc aggttcaagc aattctcctg cctcggcctc      600

ctgagtagct gggactatag gcacccacca ccatgcacag ctaatttttg tatttttagt      660

agagacaggg tttcactatg ttggccaggc tggtctcgac ctcctgacct cgtgatctgc      720

ctgccttggc ctcccaaagt gctgggatta caggcgtgag ccaccatgcc cagcccctgc      780

actaattttt taaacaaagt cctgttggtg ctcccttcaa aatttatctc cagtctgacc      840

attttaccac ttctgcaaca acccttctga ctcagccact gttctgtttg gtttgggtta      900

catagtggca tcctacctgg tcttcctgtt tccactctta taccactaga ccatattctc      960

cataaaccac cagagtgatc ttttaaaata aaagcataaa ttatgttcaa aaccctccag     1020

tggcatccat ctcatgtaaa taaccactcc ttcctacaag atgccacctc acctgccccg     1080

actgcctcat catagttccc tctgcacaat gcccactttg ccacagctgt gtgctcctgc     1140

tggctcttgg atgagcccac cagtcacact tctgcctgag ggccttgcac atgctctggt     1200

tgctgcctga gatacttatc cccatcacta tgatcacctt cccagagagg catttcctgg     1260

cctccctatt tcctcaccac catcatttct gtctgctgac tctactttgt ctgttggttg     1320

atttttgcac taagcgtact accagaagct ttcctctcaa tttgctttcc cacagtaaaa     1380

gagcagggcc tttgccttgt ccattagttt ctcctcagaa cagtgcctcc caggtgttca     1440

acaaatactt gctaaataaa agatggctga tagcaaaaat atttatgtct atgtataggg     1500

acttagtttt tattgacatt gtgcttttat tccctagaga ccctgaaata tggcgtctgg     1560

cctgcttgaa agtttggggc agaagctgta ttaaacttgt tccgtacacg tcctggagag     1620

agatgttttt agaacggcct cgtgttcggt ttgatggcgt gtatatcagt aaaaccacat     1680

atattcgtca aggggaacag tctcttgatg gtttctatag agcctggcac caagtggaat     1740

attacaggta caactgtagt acactgagtg agtggaaaat tctctctctc catgtattag     1800

ttaaatggac atctgttctt tgttgctttt gattgacccg caaaatggcc ctcagtattt     1860

ttatctagta ctcaatgtag gaattgcact aaaaaaaaaa ataggctaat ataaattaca     1920

gaatttcttc tggcctcttt tagatttctt cttgtctttt gccctgggtg tatttacttg     1980

ccttttcaaa tagcttgtgc ttttattcca ccttattgct tgccaaatat tattgtcatt     2040

tagaaaaaaa tagacatgtt aaccgttgtg tgtggctctc actttgtttg aaattgttgc     2100

tttgggaaaa acacagaact ttaataaaac aatatttgac ttttattcag tgagtaaaac     2160

ttaaaagttc aacagtttcc cctgaggaag ataaaatatc tttggttctt tgttgctgga     2220

ctaacaggta gtcagtaata tttgttttaa tgttttagca gttctttagc ccgtggtatt     2280

tcagtgttgg tttcatagct atgaataggc ataggtacta atagataagg acatatttta     2340

tactttgtgt ggggggtgtg ttttggtctt ccttttctta ttacataggt acataagatt     2400

ctttcctgat ggccatgtga tgatgttgac aacccctgaa gagcctcagt ccattgttcc     2460

acgtttaaga actaggaata ccaggactga tgcaattcta ctgggtcact atcgcttgtc     2520

acaagacaca gacaatcaga ccaaagtatt tgctgtaat                            2559


<210>  953
<211>  4694
<212>  DNA
<213>  Homo Sapiens

<400>  953
agaagaggcg ggggcttcct gcttcagcct ccttgggcag aagcagtgac cacaggcccc       60

catggcaggc agggcgggtg ggaggagggt gatttacaag gcagatgggc ctctggctac      120

agctcagtcc tgcactcagc cagggccacc ccaggggcta taagagcaac tagatttctg      180

gagcagctcg gggatgggtg ccatttgagc ccagcttggc tccccctcct ggctggcctc      240

cttcctgccc ttctgcctgc ctgtgtctgc tgagattctg caaagaggaa cgcttggcac      300

catgtctctg ctcaaccctg tcctgctgcc ccccaaggtg aaggcctatc tgagccaagg      360

ggagcgcttc atcaaatggg atgatgaaac tacagttgcc tctccagtta tcctccgtgt      420

ggatcctaag ggctactact tatactggac gtatcaaagt aaggagatgg agtttctgga      480

tatcaccagc atccgggata ctcgctttgg gaagtttgcc aagatgccca agagccagaa      540

gctccgggac gtcttcaaca tggactttcc tgataacagt ttcctgctga agacactcac      600

ggtggtgtcc ggcccggaca tggtggacct caccttccac aacttcgtct cctacaagga      660

gaacgtgggc aaggcctggg ctgaggacgt actggcccta gtcaaacatc cgctgacggc      720

caacgcctcc cgcagcacct tcctggacaa gatccttgtg aagctcaaga tgcagctcaa      780

ctctgaaggg aagattccgg tgaagaactt tttccagatg tttcctgctg accgcaagcg      840

ggtggaagct gctctcagtg cctgccacct ccccaaaggc aaaaatgacg ccatcaatcc      900

tgaggacttc ccagaacctg tctacaagag tttcctcatg agcctctgtc ctcggccaga      960

aatagatgag atcttcactt cttaccatgc taaggccaaa ccctacatga cgaaggagca     1020

cctgaccaaa ttcatcaacc agaaacagcg ggactcccgg cttaactccc tgctgttccc     1080

gccagcacgg cctgaccagg tgcagggcct catcgacaag tatgagccca gtggcatcaa     1140

tgcacagagg ggccagctgt cacctgaagg catggtctgg tttctctgtg ggccagagaa     1200

cagcgtgctg gcccaggaca agctgctgct ccaccacgac atgacgcagc cactcaatca     1260

ttacttcatc aactcgtccc acaacaccta cctgacagcc ggccagttct caggcctctc     1320

ctcggctgag atgtaccgcc aggtgctgct ctctggctgc cgttgcgtgg agctagactg     1380

ctggaagggg aaaccccctg acgaggagcc cattatcacc catggcttca ccatgaccac     1440

agacatcttc ttcaaagaag caattgaggc tattgcagaa agcgccttta agacctcccc     1500

ctatcccatc atcctgtcgt ttgagaacca tgtggactca ccccgccagc aggctaagat     1560

ggctgagtat tgccggacga tctttgggga tatgctgctc acagagcccc tggaaaagtt     1620

cccactaaaa ccaggtgtcc ccctgcccag ccctgaggat ctcaggggca agatcctcat     1680

caagaacaag aagaaccagt tttctggccc cacctcctcc agtaaggata ctggtgggga     1740

ggctgagggc agcagcccac ccagtgcccc tgcaggtgag ggcacagtgt gggctggcga     1800

ggaagggact gagctggagg aggaggaggt ggaagaggaa gaggaggagg agtcaggaaa     1860

cctggatgaa gaagagatta agaagatgca gtcggatgag ggcacagcgg gcctggaagt     1920

gacggcttat gaggagatgt ccagcctagt caattacatc cagcccacca agttcgtctc     1980

ctttgagttc tctgcccaaa agaaccgaag ttatgtcatc tcgtccttca cagagctcaa     2040

ggcatatgac ctgctctcca aggcctcggt gcagtttgtg gactacaaca agcgccagat     2100

gagccgcatt taccccaagg gaacccgcat ggactcctcc aactacatgc cccagatgtt     2160

ctggaatgct ggatgccaga tggttgccct caacttccag acgatggact tgcccatgca     2220

gcagaacatg gcagtatttg agttcaacgg gcagagcggc tacctcctca agcatgagtt     2280

catgcgccgg ccggacaagc agttcaaccc cttctcagtg gaccgcatcg acgtggtggt     2340

ggccaccacc ctttccatta cggtgatctc tgggcagttc ctgtcagaac gcagcgtgcg     2400

cacctatgta gaagtggagc tgtttggcct tcctggggac cccaagaggc gctatcgaac     2460

taagctgtca cccagtacta actccatcaa tcctgtctgg aaggaggagc cctttgtctt     2520

tgagaagatc ttgatgcctg agctggcctc cctcagagtg gctgtgatgg aggaaggcaa     2580

caagtttctt ggacaccgca tcatccccat caatgcccta aattctgggt accaccacct     2640

gtgcctgcac agtgagagca acatgcccct caccatgcct gcgctcttca tcttcctgga     2700

gatgaaggac tacatacctg gtgcttgggc agatctcact gtggccctcg ccaaccccat     2760

taagttcttc agtgcccatg acacgaagtc tgtgaagctc aaggaggcca tgggaggtct     2820

gcctgagaag cccttcccac tggcgagtcc agttgccagc caggtcaatg gggcgttggc     2880

cccaacgagc aatgggtcac cagcagccag ggccggggcc agggaagagg ctatgaaaga     2940

agctgcggag ccgcggaccg ccagcctgga ggagctccgg gagctaaagg gcgtggtgaa     3000

gctgcagcgg cggcacgaga aggagctgcg agagttggag cggcgcggag cgcggcgctg     3060

ggaggagctg ctgcagcggg gcgcggcgca gctggcggag ctcgggccac cgggcgtggg     3120

gggcgtcggg gcctgcaagc tcggtcccgg caagggctct cgcaagaaga ggagcctgcc     3180

ccgcgaggag agcgccggag ccgcgccggg cgagggccct gagggcgtgg acgggcgcgt     3240

gcgggagctg aaagacaggc tggagctgga gctgctgcgg cagggcgagg agcagtacga     3300

gtgcgttctg aagcgcaagg agcagcacgt ggccgagcaa atctccaaaa tgatggagct     3360

ggccagagag aaacaggcgg cagagctgaa ggccctgaag gagacgtcgg agaacgacac     3420

caaagagatg aagaaaaagc tggagacaaa gagactggag cggatccagg gcatgaccaa     3480

agtcaccaca gacaagatgg cccaggagag gttgaagaga gagattaaca actcccacat     3540

ccaggaagta gtgcaggtga tcaagcagat gacggagaac ttggagaggc accaggagaa     3600

gctggaggag aagcaggcgg cttgcctgga acagatacgg gagatggaaa agcagttcca     3660

gaaggaggcg ctggcagagt acgaggccag gatgaagggt ctggaggcag aggtgaagga     3720

gtcggtgagg gcctgcctca ggacctgctt tccctccgag gccaaggaca agcctgagag     3780

ggcctgcgag tgccccccag agctgtgtga gcaggaccca ctcatagcaa aggcagatgc     3840

ccaggagagc cgcctctgat gcccccatcc cactgggaca tttagcaagg aggttcagcc     3900

ccttctctgg gatgtggttc tattccccca ggaaaaagga gccccagcct tctgaggctg     3960

tgggaacctg tggctgcctt ggacgctgca gccccctcct caacggccag gccagagtct     4020

gagacaggac ccaggcaccc tcacggcagg gcctctctgg ggcctagaag tcttctcaag     4080

ctgacttcct acctccccct ccatctctag ataagtgtca tatatttgtt gagggcaaaa     4140

gactatggac tggaaggcag aaagtgggat cctggcccca ctctgccttt cctattgagc     4200

aaccagctct gggctcagtt tcctcacctg gagggttgga cccactcacc tccactctag     4260

ccccgaaccc tcctgcccca ggcttccagg ccccatcagg cctgccctga gttggccttg     4320

tccactcctt gaggcagatc ctggcactac ctcacagctc cctggggacg gccactccct     4380

ggctgagggc cctcccctcc cctctgcctg tccggaacgg gaggctgaaa tggaaaagct     4440

gccttggccc tgcttggctg agtcacaagg ggcagtgggc tcttgggtgc tgttccaccc     4500

tgaccctggc tcacccctct tcctaggcct gggggcaggc agttcctacc atgtacccct     4560

ctcaggctgc ctgcctgaca aggtcagcat catttgctct cctgaattta tgaggtttat     4620

ttatttttct ctttcctact cctattaaag aacctcgtcc cagtgtttcc tgcttaaaaa     4680

aaaaaaaaaa aaaa                                                       4694


<210>  954
<211>  1185
<212>  PRT
<213>  Homo Sapiens

<400>  954

Met Ser Leu Leu Asn Pro Val Leu Leu Pro Pro Lys Val Lys Ala Tyr 
1               5                   10                  15      


Leu Ser Gln Gly Glu Arg Phe Ile Lys Trp Asp Asp Glu Thr Thr Val 
            20                  25                  30          


Ala Ser Pro Val Ile Leu Arg Val Asp Pro Lys Gly Tyr Tyr Leu Tyr 
        35                  40                  45              


Trp Thr Tyr Gln Ser Lys Glu Met Glu Phe Leu Asp Ile Thr Ser Ile 
    50                  55                  60                  


Arg Asp Thr Arg Phe Gly Lys Phe Ala Lys Met Pro Lys Ser Gln Lys 
65                  70                  75                  80  


Leu Arg Asp Val Phe Asn Met Asp Phe Pro Asp Asn Ser Phe Leu Leu 
                85                  90                  95      


Lys Thr Leu Thr Val Val Ser Gly Pro Asp Met Val Asp Leu Thr Phe 
            100                 105                 110         


His Asn Phe Val Ser Tyr Lys Glu Asn Val Gly Lys Ala Trp Ala Glu 
        115                 120                 125             


Asp Val Leu Ala Leu Val Lys His Pro Leu Thr Ala Asn Ala Ser Arg 
    130                 135                 140                 


Ser Thr Phe Leu Asp Lys Ile Leu Val Lys Leu Lys Met Gln Leu Asn 
145                 150                 155                 160 


Ser Glu Gly Lys Ile Pro Val Lys Asn Phe Phe Gln Met Phe Pro Ala 
                165                 170                 175     


Asp Arg Lys Arg Val Glu Ala Ala Leu Ser Ala Cys His Leu Pro Lys 
            180                 185                 190         


Gly Lys Asn Asp Ala Ile Asn Pro Glu Asp Phe Pro Glu Pro Val Tyr 
        195                 200                 205             


Lys Ser Phe Leu Met Ser Leu Cys Pro Arg Pro Glu Ile Asp Glu Ile 
    210                 215                 220                 


Phe Thr Ser Tyr His Ala Lys Ala Lys Pro Tyr Met Thr Lys Glu His 
225                 230                 235                 240 


Leu Thr Lys Phe Ile Asn Gln Lys Gln Arg Asp Ser Arg Leu Asn Ser 
                245                 250                 255     


Leu Leu Phe Pro Pro Ala Arg Pro Asp Gln Val Gln Gly Leu Ile Asp 
            260                 265                 270         


Lys Tyr Glu Pro Ser Gly Ile Asn Ala Gln Arg Gly Gln Leu Ser Pro 
        275                 280                 285             


Glu Gly Met Val Trp Phe Leu Cys Gly Pro Glu Asn Ser Val Leu Ala 
    290                 295                 300                 


Gln Asp Lys Leu Leu Leu His His Asp Met Thr Gln Pro Leu Asn His 
305                 310                 315                 320 


Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Phe 
                325                 330                 335     


Ser Gly Leu Ser Ser Ala Glu Met Tyr Arg Gln Val Leu Leu Ser Gly 
            340                 345                 350         


Cys Arg Cys Val Glu Leu Asp Cys Trp Lys Gly Lys Pro Pro Asp Glu 
        355                 360                 365             


Glu Pro Ile Ile Thr His Gly Phe Thr Met Thr Thr Asp Ile Phe Phe 
    370                 375                 380                 


Lys Glu Ala Ile Glu Ala Ile Ala Glu Ser Ala Phe Lys Thr Ser Pro 
385                 390                 395                 400 


Tyr Pro Ile Ile Leu Ser Phe Glu Asn His Val Asp Ser Pro Arg Gln 
                405                 410                 415     


Gln Ala Lys Met Ala Glu Tyr Cys Arg Thr Ile Phe Gly Asp Met Leu 
            420                 425                 430         


Leu Thr Glu Pro Leu Glu Lys Phe Pro Leu Lys Pro Gly Val Pro Leu 
        435                 440                 445             


Pro Ser Pro Glu Asp Leu Arg Gly Lys Ile Leu Ile Lys Asn Lys Lys 
    450                 455                 460                 


Asn Gln Phe Ser Gly Pro Thr Ser Ser Ser Lys Asp Thr Gly Gly Glu 
465                 470                 475                 480 


Ala Glu Gly Ser Ser Pro Pro Ser Ala Pro Ala Gly Glu Gly Thr Val 
                485                 490                 495     


Trp Ala Gly Glu Glu Gly Thr Glu Leu Glu Glu Glu Glu Val Glu Glu 
            500                 505                 510         


Glu Glu Glu Glu Glu Ser Gly Asn Leu Asp Glu Glu Glu Ile Lys Lys 
        515                 520                 525             


Met Gln Ser Asp Glu Gly Thr Ala Gly Leu Glu Val Thr Ala Tyr Glu 
    530                 535                 540                 


Glu Met Ser Ser Leu Val Asn Tyr Ile Gln Pro Thr Lys Phe Val Ser 
545                 550                 555                 560 


Phe Glu Phe Ser Ala Gln Lys Asn Arg Ser Tyr Val Ile Ser Ser Phe 
                565                 570                 575     


Thr Glu Leu Lys Ala Tyr Asp Leu Leu Ser Lys Ala Ser Val Gln Phe 
            580                 585                 590         


Val Asp Tyr Asn Lys Arg Gln Met Ser Arg Ile Tyr Pro Lys Gly Thr 
        595                 600                 605             


Arg Met Asp Ser Ser Asn Tyr Met Pro Gln Met Phe Trp Asn Ala Gly 
    610                 615                 620                 


Cys Gln Met Val Ala Leu Asn Phe Gln Thr Met Asp Leu Pro Met Gln 
625                 630                 635                 640 


Gln Asn Met Ala Val Phe Glu Phe Asn Gly Gln Ser Gly Tyr Leu Leu 
                645                 650                 655     


Lys His Glu Phe Met Arg Arg Pro Asp Lys Gln Phe Asn Pro Phe Ser 
            660                 665                 670         


Val Asp Arg Ile Asp Val Val Val Ala Thr Thr Leu Ser Ile Thr Val 
        675                 680                 685             


Ile Ser Gly Gln Phe Leu Ser Glu Arg Ser Val Arg Thr Tyr Val Glu 
    690                 695                 700                 


Val Glu Leu Phe Gly Leu Pro Gly Asp Pro Lys Arg Arg Tyr Arg Thr 
705                 710                 715                 720 


Lys Leu Ser Pro Ser Thr Asn Ser Ile Asn Pro Val Trp Lys Glu Glu 
                725                 730                 735     


Pro Phe Val Phe Glu Lys Ile Leu Met Pro Glu Leu Ala Ser Leu Arg 
            740                 745                 750         


Val Ala Val Met Glu Glu Gly Asn Lys Phe Leu Gly His Arg Ile Ile 
        755                 760                 765             


Pro Ile Asn Ala Leu Asn Ser Gly Tyr His His Leu Cys Leu His Ser 
    770                 775                 780                 


Glu Ser Asn Met Pro Leu Thr Met Pro Ala Leu Phe Ile Phe Leu Glu 
785                 790                 795                 800 


Met Lys Asp Tyr Ile Pro Gly Ala Trp Ala Asp Leu Thr Val Ala Leu 
                805                 810                 815     


Ala Asn Pro Ile Lys Phe Phe Ser Ala His Asp Thr Lys Ser Val Lys 
            820                 825                 830         


Leu Lys Glu Ala Met Gly Gly Leu Pro Glu Lys Pro Phe Pro Leu Ala 
        835                 840                 845             


Ser Pro Val Ala Ser Gln Val Asn Gly Ala Leu Ala Pro Thr Ser Asn 
    850                 855                 860                 


Gly Ser Pro Ala Ala Arg Ala Gly Ala Arg Glu Glu Ala Met Lys Glu 
865                 870                 875                 880 


Ala Ala Glu Pro Arg Thr Ala Ser Leu Glu Glu Leu Arg Glu Leu Lys 
                885                 890                 895     


Gly Val Val Lys Leu Gln Arg Arg His Glu Lys Glu Leu Arg Glu Leu 
            900                 905                 910         


Glu Arg Arg Gly Ala Arg Arg Trp Glu Glu Leu Leu Gln Arg Gly Ala 
        915                 920                 925             


Ala Gln Leu Ala Glu Leu Gly Pro Pro Gly Val Gly Gly Val Gly Ala 
    930                 935                 940                 


Cys Lys Leu Gly Pro Gly Lys Gly Ser Arg Lys Lys Arg Ser Leu Pro 
945                 950                 955                 960 


Arg Glu Glu Ser Ala Gly Ala Ala Pro Gly Glu Gly Pro Glu Gly Val 
                965                 970                 975     


Asp Gly Arg Val Arg Glu Leu Lys Asp Arg Leu Glu Leu Glu Leu Leu 
            980                 985                 990         


Arg Gln Gly Glu Glu Gln Tyr Glu  Cys Val Leu Lys Arg  Lys Glu Gln 
        995                 1000                 1005             


His Val  Ala Glu Gln Ile Ser  Lys Met Met Glu Leu  Ala Arg Glu 
    1010                 1015                 1020             


Lys Gln  Ala Ala Glu Leu Lys  Ala Leu Lys Glu Thr  Ser Glu Asn 
    1025                 1030                 1035             


Asp Thr  Lys Glu Met Lys Lys  Lys Leu Glu Thr Lys  Arg Leu Glu 
    1040                 1045                 1050             


Arg Ile  Gln Gly Met Thr Lys  Val Thr Thr Asp Lys  Met Ala Gln 
    1055                 1060                 1065             


Glu Arg  Leu Lys Arg Glu Ile  Asn Asn Ser His Ile  Gln Glu Val 
    1070                 1075                 1080             


Val Gln  Val Ile Lys Gln Met  Thr Glu Asn Leu Glu  Arg His Gln 
    1085                 1090                 1095             


Glu Lys  Leu Glu Glu Lys Gln  Ala Ala Cys Leu Glu  Gln Ile Arg 
    1100                 1105                 1110             


Glu Met  Glu Lys Gln Phe Gln  Lys Glu Ala Leu Ala  Glu Tyr Glu 
    1115                 1120                 1125             


Ala Arg  Met Lys Gly Leu Glu  Ala Glu Val Lys Glu  Ser Val Arg 
    1130                 1135                 1140             


Ala Cys  Leu Arg Thr Cys Phe  Pro Ser Glu Ala Lys  Asp Lys Pro 
    1145                 1150                 1155             


Glu Arg  Ala Cys Glu Cys Pro  Pro Glu Leu Cys Glu  Gln Asp Pro 
    1160                 1165                 1170             


Leu Ile  Ala Lys Ala Asp Ala  Gln Glu Ser Arg Leu  
    1175                 1180                 1185 


<210>  955
<211>  2037
<212>  DNA
<213>  Homo Sapiens

<400>  955
agaccgcctc ttccttcccg ttgtttaagg cagttggttg ccctcctgtc cgtcagaggt       60

gcagtaccag aggtggcgtg ctgccgattt cgcgtttgcc ttgctggatg attccgcttg      120

tttgccggct gcgtgagtgc ttagagcttt tcggtggaag atgccggaca gtaacttcgc      180

agagcgcagc gaggagcagg tgtctggtgc taaagtcatc gctcaggccc tgaaaacgca      240

agatgtggag tacatatttg gcatcgtagg catcccagtg accgaaatcg ccattgctgc      300

ccagcagcta ggcatcaagt acatcgggat gaggaatgag caagcggctt gttatgctgc      360

ctccgcgatt ggatatctga caagcaggcc aggagtctgc cttgttgttt ctggcccagg      420

tctcatccat gccttgggcg gtatggcaaa tgcaaacatg aactgctggc ccttgcttgt      480

gattggtggt tcctctgaaa gaaaccaaga aacaatggga gctttccagg agtttcctca      540

ggttgaagct tgtagattat ataccaagtt ctctgcccgc ccaagcagca tagaagctat      600

tccttttgtt attgaaaagg cagtgagaag cagtatctat ggtcgtccag gtgcttgcta      660

tgttgacata ccagcagatt ttgtgaacct tcaggtgaat gtgaattcta taaagtacat      720

ggaacgctgc atgtcacctc ctattagcat ggcagaaacc tctgctgtgt gcacggcggc      780

ttctgttatt aggaatgcca aacaacccct tcttatcatc gggaaaggtg ctgcttacgc      840

tcatgcagaa gagagtatca agaaattggt ggagcaatat aaactgccat ttttgcccac      900

ccctatgggg aagggtgttg tccctgacaa ccatccatac tgtgtaggtg cagccagatc      960

cagggctttg caatttgctg atgtaattgt gttatttggt gccagactaa attggatttt     1020

acattttgga ctgcctccaa gatatcagcc agatgtgaag tttatccagg ttgatatctg     1080

tgcagaagaa ttggggaata atgtaaagcc cgctgttact ttgctaggaa acatacatgc     1140

tgtcactaag cagcttttag aggaacttga taaaacacca tggcagtatc ctccagagag     1200

caagtggtgg aaaactctga gagaaaaaat gaagagcaat gaagctgcat ccaaggaact     1260

agcttctaaa aaatccctgc ctatgaatta ttacacagta ttctaccatg ttcaagaaca     1320

actacctaga gactgtttcg tggtaagtga aggagcaaat actatggaca ttggacggac     1380

tgtgcttcag aactaccttc ctcgtcacag gcttgatgct ggtactttcg gaacaatggg     1440

agttggtttg ggatttgcta ttgcagctgc cgtggtggct aaagatagaa gccctgggca     1500

atggatcatc tgtgtggaag gagacagtgc atttgggttt tctggcatgg aggtagaaac     1560

catctgcagg tacaacttgc caatcatact gttggtagtg aataacaatg gaatttacca     1620

aggttttgat acagatactt ggaaagaaat gttaaaattt caagatgcta ctgcagtggt     1680

ccctccaatg tgtttgctgc caaattcaca ttatgagcaa gtcatgactg catttggagg     1740

caaagggtat tttgtacaaa caccagaaga actccaaaaa tccctgaggc agagcctagc     1800

agacacaact aaaccttctc ttatcaacat catgattgag ccacaagcca cacggaaggc     1860

ccaggatttt cattggctga cccgctctaa tatgtaaata aagacgccag ttggtggtct     1920

tgagttttct ctttcttgca agatgaaatt ttattttcca cagcaaaatt actctactgt     1980

taaaattgtg caaaataaaa taaacattta aaatgacatt ttacagtaaa aaaaaaa        2037


<210>  956
<211>  578
<212>  PRT
<213>  Homo Sapiens

<400>  956

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Val Ser Gly Pro Gly Leu Ile His Ala Leu Gly Gly Met Ala 
                85                  90                  95      


Asn Ala Asn Met Asn Cys Trp Pro Leu Leu Val Ile Gly Gly Ser Ser 
            100                 105                 110         


Glu Arg Asn Gln Glu Thr Met Gly Ala Phe Gln Glu Phe Pro Gln Val 
        115                 120                 125             


Glu Ala Cys Arg Leu Tyr Thr Lys Phe Ser Ala Arg Pro Ser Ser Ile 
    130                 135                 140                 


Glu Ala Ile Pro Phe Val Ile Glu Lys Ala Val Arg Ser Ser Ile Tyr 
145                 150                 155                 160 


Gly Arg Pro Gly Ala Cys Tyr Val Asp Ile Pro Ala Asp Phe Val Asn 
                165                 170                 175     


Leu Gln Val Asn Val Asn Ser Ile Lys Tyr Met Glu Arg Cys Met Ser 
            180                 185                 190         


Pro Pro Ile Ser Met Ala Glu Thr Ser Ala Val Cys Thr Ala Ala Ser 
        195                 200                 205             


Val Ile Arg Asn Ala Lys Gln Pro Leu Leu Ile Ile Gly Lys Gly Ala 
    210                 215                 220                 


Ala Tyr Ala His Ala Glu Glu Ser Ile Lys Lys Leu Val Glu Gln Tyr 
225                 230                 235                 240 


Lys Leu Pro Phe Leu Pro Thr Pro Met Gly Lys Gly Val Val Pro Asp 
                245                 250                 255     


Asn His Pro Tyr Cys Val Gly Ala Ala Arg Ser Arg Ala Leu Gln Phe 
            260                 265                 270         


Ala Asp Val Ile Val Leu Phe Gly Ala Arg Leu Asn Trp Ile Leu His 
        275                 280                 285             


Phe Gly Leu Pro Pro Arg Tyr Gln Pro Asp Val Lys Phe Ile Gln Val 
    290                 295                 300                 


Asp Ile Cys Ala Glu Glu Leu Gly Asn Asn Val Lys Pro Ala Val Thr 
305                 310                 315                 320 


Leu Leu Gly Asn Ile His Ala Val Thr Lys Gln Leu Leu Glu Glu Leu 
                325                 330                 335     


Asp Lys Thr Pro Trp Gln Tyr Pro Pro Glu Ser Lys Trp Trp Lys Thr 
            340                 345                 350         


Leu Arg Glu Lys Met Lys Ser Asn Glu Ala Ala Ser Lys Glu Leu Ala 
        355                 360                 365             


Ser Lys Lys Ser Leu Pro Met Asn Tyr Tyr Thr Val Phe Tyr His Val 
    370                 375                 380                 


Gln Glu Gln Leu Pro Arg Asp Cys Phe Val Val Ser Glu Gly Ala Asn 
385                 390                 395                 400 


Thr Met Asp Ile Gly Arg Thr Val Leu Gln Asn Tyr Leu Pro Arg His 
                405                 410                 415     


Arg Leu Asp Ala Gly Thr Phe Gly Thr Met Gly Val Gly Leu Gly Phe 
            420                 425                 430         


Ala Ile Ala Ala Ala Val Val Ala Lys Asp Arg Ser Pro Gly Gln Trp 
        435                 440                 445             


Ile Ile Cys Val Glu Gly Asp Ser Ala Phe Gly Phe Ser Gly Met Glu 
    450                 455                 460                 


Val Glu Thr Ile Cys Arg Tyr Asn Leu Pro Ile Ile Leu Leu Val Val 
465                 470                 475                 480 


Asn Asn Asn Gly Ile Tyr Gln Gly Phe Asp Thr Asp Thr Trp Lys Glu 
                485                 490                 495     


Met Leu Lys Phe Gln Asp Ala Thr Ala Val Val Pro Pro Met Cys Leu 
            500                 505                 510         


Leu Pro Asn Ser His Tyr Glu Gln Val Met Thr Ala Phe Gly Gly Lys 
        515                 520                 525             


Gly Tyr Phe Val Gln Thr Pro Glu Glu Leu Gln Lys Ser Leu Arg Gln 
    530                 535                 540                 


Ser Leu Ala Asp Thr Thr Lys Pro Ser Leu Ile Asn Ile Met Ile Glu 
545                 550                 555                 560 


Pro Gln Ala Thr Arg Lys Ala Gln Asp Phe His Trp Leu Thr Arg Ser 
                565                 570                 575     


Asn Met 
        


<210>  957
<211>  7169
<212>  DNA
<213>  Homo Sapiens

<400>  957
cacggtgcct gcacgggacg ccgctcgatc cccgagcccc ctcgccgtcc ccgacagccc       60

ccccggcgcc atgcaatccc ggcttctact cctcggggca cccggaggcc acggcggccc      120

ggcctcgcgg cgcatgcggc tgctcctgcg gcaggtggtg cagcgcaggc cgggtggcga      180

caggcagcgg ccggaggtca gactgttgca cgccggctcg ggggccgaca caggtgatac      240

agttaatatt ggagatgtat cctacaagtt gaaaattcct aagaatccag aacttgtgcc      300

acagaactac atttcagact ctctggctca atctgtagtt cagcatctaa gatggataat      360

gcagaaggat cttttggggc aagatgtttt tctaatagga cctcctgggc ctcttcgacg      420

ctctattgct atgcagtact tggagctgac caaacgggag gtcgaataca ttgccctgtc      480

aagggacacc actgaaactg atctcaaaca gcgacgagag atccgtgcag gcacagcctt      540

ttacattgat cagtgtgcag ttcgtgcagc cacagaaggc agaactctca ttttggaagg      600

tttggaaaag gcagagagga atgttttgcc tgttttgaac aacttgctgg aaaacagaga      660

gatgcagctt gaagatggac gcttcctgat gtctgctgag cgttacgaca aacttctccg      720

agatcatacc aaaaaagagt tggattcttg gaaaattgtc cgagttagtg aaaatttccg      780

agtgattgcc ttgggcttgc cagtgccaag gtattctggg aatccattag acccccctct      840

tcgttctcga tttcaagcca gggatattta ttatttaccc ttcaaggacc aacttaagtt      900

gttatattca attggagcca atgtttctgc tgagaaagtt tctcagctct tgtcctttgc      960

cacaactctg tgttcccaag aatcttctac tcttggactt ccagactttc ctttagatag     1020

tttagcagct gcggttcaaa tcttggattc ctttcctatg atgccaatca aacatgcaat     1080

ccagtggctt tatccatata gtattttact aggtcatgaa gggaagatgg ctgtggaagg     1140

tgttttaaag cgctttgaac ttcaagattc aggaagctct ctacttccta aagagattgt     1200

aaaagtagag aagatgatgg aaaaccatgt gtcccaagct tctgtgacca tccggattgc     1260

agataaagag gtgaccatta aggtgccagc cgggaccagg ctattaagtc aaccttgtgc     1320

gtcagaccgt ttcatacaga ctttgagcca taagcagcta caggctgaaa tgatgcagtc     1380

tcacatggtt aaagatatat gtttaattgg aggaaagggt tgtggaaaaa cagtgatcgc     1440

taagaacttt gccgatacct taggatacaa catagaacct attatgctct atcaggatat     1500

gacagcgcgt gatctgctac agcagagata cacccttcca aatggagaca ctgcctggcg     1560

gtcctcaccc cttgtgaatg ctgctctgga aggcaagctg gtcctgctgg atggcattca     1620

ccgggtgaat gcgggcacgc ttgctgtatt gcaaaggtta atccatgatc gagagctaag     1680

cctctatgat ggttctaggc tgctgagaga agacaggtat atgcgtttaa aggaggagct     1740

gcaactgtct gatgaacagc tacagaagag atccattttt cctatccatc cctccttcag     1800

aatcattgcc ttggcagaac cccctgttat tggaagcaca gcacaccagt ggctgggacc     1860

agaattctta accatgttct ttttccatta catgaaacca cttgtgaaaa gtgaagaaat     1920

ccaagtgatt aaggaaaagg tcccaaatgt acctcaggaa gctctggata agttattatc     1980

atttacacac aaactcagag aaacacagga tccaacggca caatcattag cggcatcact     2040

ttctaccaga caactgttgc gaatttctcg tcggctgtca cagtatccta atgaaaatct     2100

tcacagtgct gttactaaag cctgcctttc caggttttta cccagtcttg ctaggtcagc     2160

attagaaaaa aatctggcag atgctacaat agaaataaat actgatgaca atttggagcc     2220

agaactgaag gattacaaat gtgaagtaac atctggaact ctgaggattg gtgctgttag     2280

tgcaccgatc tataatgcac atgagaaaat gaaagtgcct gatgttcttt tctatgacaa     2340

cattcagcat gtgatagtga tggaagatat gctgaaagac tttctccttg gagaacactt     2400

attattggtt ggcaaccagg gtgtaggaaa aaacaagatt gttgacagat tccttcacct     2460

gctcaacaga ccccgagaat atattcagct acacagggat accacagtac aaactcttac     2520

gcttcagcct tcggttaaag acggacttat tgtatatgaa gactcacctt tggttaaagc     2580

agtaaagttg ggtcatattc tggtagtaga tgaggctgac aaagctccaa caaatgtcac     2640

gtgtatttta aaaactctag tagaaaatgg agaaatgatt ctagcagatg gaagacgcat     2700

tgttgcaaat tctgctaatg tgaatggaag agaaaatgtt gtagtgattc atcctgattt     2760

taggatgatt gttctggcaa atagacctgg atttcctttc ctaggcaatg atttcttcgg     2820

taccttaggt gatattttta gctgccatgc agttgataac cccaaacccc actcggagct     2880

cgagatgctc agacagtatg gaccaaatgt gcctgagccc atccttcaga agcttgtggc     2940

tgcctttgga gagctgagga gtttggctga ccaagggatt attaactatc cttattctac     3000

cagagaagtt gtcaacatag tcaaacattt acagaaattt ccgactgaag gtctctccag     3060

tgtagttcga aatgtgtttg actttgattc ctacaacaat gacatgaggg agatattgat     3120

taacacttta cacaaatacg ggatacctat cggagcaaag cctaccagtg tgcagctggc     3180

aaaggagttg actctgccag aacaaacgtt catgggctac tggacaattg gtcaggcaag     3240

aagtgggatg caaaaactct tgtgtccagt ggaaactcat catatagaca taaagggtcc     3300

agcacttata aatatacagg agtatccaat agaaagacat gaagaaagat ccctaaactt     3360

tactgaagaa tgtgcctcat ggagaatacc attggatgaa attaatataa tctgtgacat     3420

tgctacatca catgaaaatg agcaaaatac tctctatgta gttacatgca atcccgcttc     3480

cctgtacttt atgaatatga ctgggaaaag tggcttcttt gtggactttt ttgatatctt     3540

cccaagaaca gccaatggcg tttggcaccc ttttgtgaca gtggcaccgc tgggaagtcc     3600

tctcaaaggt caagtggttc tccatgagca gcagagtaat gttatcctgt tgttagatac     3660

tactggccgg gcccttcatc gtctcatcct cccttccgag aagtttacat ctaagaaacc     3720

tttctggtgg aacaaagaag aagctgaaac ttataaaatg tgtaaagaat tttcacacaa     3780

aaactggctg gtgttctaca aagaaaaagg gaacagcctg actgtgctgg atgttctaga     3840

agggcgaact cacaccatct cacttcccat caacctcaag acagttttcc ttgtagcaga     3900

ggacaaatgg cttctggtgg agagcaaaac aaatcagaaa tatcttttaa ctaagcctgc     3960

acacatcgaa tctgagggta gtggggtttg ccagttgtat gtgctgaaag aggagccgcc     4020

cagcacaggg tttggagtta cacaagaaac agagttcagc atacctcata aaatttccag     4080

tgatcaacta tcatctgaac atctaagttc agctgtggaa caaaagattg cctctcccaa     4140

cagaattctc tcagatgaga aaaattatgc tacaatagtt gttggttttc cagatctcat     4200

gtcacccagt gaagtttatt cttggaagag accatcatct ttgcataaac gaagtggcac     4260

tgatacatca ttctatagag gaaagaagaa aagggggact ccaaaacaaa gcaattgtgt     4320

gactctttta gatacgaatc aggtagtgag gattttaccc ccaggagaag tccctctaaa     4380

agatatctac ccaaaagatg ttactcctcc acaaacatct ggttatatag aagtcactga     4440

tcttcaatca aagaaactcc gatatatccc tattcccaga tcagaatctc tctcgccgta     4500

taccacatgg ctgtcgacca tttcagacac agatgcactg ctggctgagt gggacaaaag     4560

cggtgttgtt actgttgata tgggaggtca catcaggctt tgggaaactg gacttgaacg     4620

tctgcagcga tcactcatgg aatggagaaa catgattgga caagatgaca gaaatatgca     4680

gataacaatc aacagagaca gtggtgaaga tgtaagctcc cccaaacacg ggaaggagga     4740

cccagacaac atgcctcacg tgggcggcaa cacttgggct ggcggaacag ggggaagaga     4800

cacggcaggc ctgggtggca aaggaggccc ttaccggctg gatgcaggcc atacggtgta     4860

ccaggtctct caggctgaga aagatgcagt tcccgaagag gtcaagagag ctgctagaga     4920

gatgggccag agagcattcc agcagaggct aaaggagatc caaatgagtg aatacgatgc     4980

tgcaacctat gaaaggtttt caggtgctgt tcggcgacag gtgcactccc tccgaatcat     5040

cctggataat ttacaggcta aaggtaaaga aagacaatgg ctaagacatc aagctactgg     5100

agaattagat gatgccaaga tcattgatgg gctgactgga gaaaaagcca tctacaaacg     5160

tcggggtgag ctggagccac aacttggcag cccacaacag aaacccaagc gtctgcgcct     5220

ggtggtagat gtgtctggta gcatgtaccg tttcaacagg atggatggcc ggcttgagcg     5280

cacaatggag gctgtgtgta tggtcatgga agccttcgag aactatgagg agaagttcca     5340

gtatgacatc gttggacact ctggagatgg ctacaacatt ggtctggttc caatgaacaa     5400

aatccccaag gacaataagc aaagactaga aattctgaag acaatgcatg cccactctca     5460

gttctgcatg agtggggacc acacgttaga agggacagaa catgccatca aggaaattgt     5520

caaagaagaa gctgatgagt actttgtcat agtcttgagt gatgcaaatc tgtcacgata     5580

tggaatacat cctgctaagt ttgctcaaat cctcacaaga gaccctcaag taaatgcttt     5640

tgccattttt attggctctt taggtgatca agcaaccagg cttcagagaa ctttaccagc     5700

tggtcggtct ttcgttgcca tggataccaa ggatatccct cagattttac aacagatctt     5760

cacctccacc atgttgtcga gtgtctaaga agtgcccttc atcaccctga tgacaccagg     5820

atttgaaata agacaggaat aaagagtatt ctgaaaaaaa gaagatatgg atgaagtgaa     5880

cccatgcagt gactggatga ttccggcatt cctgggtctt cctacacttg ctccgtaatg     5940

agaattcaga gaagcagcca gaaggagact taaacatgga aagatactcc actgatgagt     6000

ttagaagtga ttagggcaag ctagttgacc tgcactttat caaaggttgg ggttaaagga     6060

aggtggtttt gagaactatg tgtttggtct atttccaaaa acctgagggg gagaaaatac     6120

tttgcttttg ccttaacaca tcatctggtc acgttagaaa agtgacccca tcaaactgag     6180

cctttgatgt cacattctga cacaagatgc aagtctgtgc aaaacccacc aaaatgctcc     6240

tatccaacaa ttatttttat tttctccctg ctctgtattg accagaaaac aatgatttta     6300

taatatttaa cccaccaaaa agtccctcca acagcaatat cttatgaaag gctggctgtt     6360

ctcaataatt tcattttctt ggccaaagcc aaaaggaatc aaaaaatcct tggagtgctt     6420

gcctttccac gtgactttta aaaggctctt aaagagcaaa tgtcctcttc tccttgctgc     6480

tagagtggga ggagaaagat gtcttgcctt aaaagtttac tgtttcttct gttcttctag     6540

catctctcaa aaaattcaca gtactccatt ttggggtcca aactgtaatg ctcaaaataa     6600

taaatgctta cacgaaaatt atttattgag aatattcata taaaaattac ctaaagcaaa     6660

gtaaaaaaag taaaatcaag gtggtatatt tgaagtgaat ggtgattgga aatttttagc     6720

tgtaacaaaa agaaagaaaa caactttttt taaagcctca ttctcttttc tttcaaaatg     6780

taccttattc ccacacactc ttgggctgac ctttatttta tcaataagct caatattact     6840

ttgtttaaaa taagatgctt cagcaaaagt cattctctct ttaaccatat aatttaaaaa     6900

ctcctcttca cgattgatag caaaatcaga aacgttaggg caccagtgag ttgaaaaaac     6960

tggtcttaag ttggaaaaac tattattaat aatattatcc tatccatcca tatctattga     7020

aattgtacag gtccataatt tcattttaat taattatagg aaagaagaaa agataatacc     7080

catttgttct atcacccctc tccctatcat taactatcaa ataaataaat aaaagcaatc     7140

tgatttccaa cgtggtacta aaaaaaaaa                                       7169


<210>  958
<211>  1905
<212>  PRT
<213>  Homo Sapiens

<400>  958

Met Gln Ser Arg Leu Leu Leu Leu Gly Ala Pro Gly Gly His Gly Gly 
1               5                   10                  15      


Pro Ala Ser Arg Arg Met Arg Leu Leu Leu Arg Gln Val Val Gln Arg 
            20                  25                  30          


Arg Pro Gly Gly Asp Arg Gln Arg Pro Glu Val Arg Leu Leu His Ala 
        35                  40                  45              


Gly Ser Gly Ala Asp Thr Gly Asp Thr Val Asn Ile Gly Asp Val Ser 
    50                  55                  60                  


Tyr Lys Leu Lys Ile Pro Lys Asn Pro Glu Leu Val Pro Gln Asn Tyr 
65                  70                  75                  80  


Ile Ser Asp Ser Leu Ala Gln Ser Val Val Gln His Leu Arg Trp Ile 
                85                  90                  95      


Met Gln Lys Asp Leu Leu Gly Gln Asp Val Phe Leu Ile Gly Pro Pro 
            100                 105                 110         


Gly Pro Leu Arg Arg Ser Ile Ala Met Gln Tyr Leu Glu Leu Thr Lys 
        115                 120                 125             


Arg Glu Val Glu Tyr Ile Ala Leu Ser Arg Asp Thr Thr Glu Thr Asp 
    130                 135                 140                 


Leu Lys Gln Arg Arg Glu Ile Arg Ala Gly Thr Ala Phe Tyr Ile Asp 
145                 150                 155                 160 


Gln Cys Ala Val Arg Ala Ala Thr Glu Gly Arg Thr Leu Ile Leu Glu 
                165                 170                 175     


Gly Leu Glu Lys Ala Glu Arg Asn Val Leu Pro Val Leu Asn Asn Leu 
            180                 185                 190         


Leu Glu Asn Arg Glu Met Gln Leu Glu Asp Gly Arg Phe Leu Met Ser 
        195                 200                 205             


Ala Glu Arg Tyr Asp Lys Leu Leu Arg Asp His Thr Lys Lys Glu Leu 
    210                 215                 220                 


Asp Ser Trp Lys Ile Val Arg Val Ser Glu Asn Phe Arg Val Ile Ala 
225                 230                 235                 240 


Leu Gly Leu Pro Val Pro Arg Tyr Ser Gly Asn Pro Leu Asp Pro Pro 
                245                 250                 255     


Leu Arg Ser Arg Phe Gln Ala Arg Asp Ile Tyr Tyr Leu Pro Phe Lys 
            260                 265                 270         


Asp Gln Leu Lys Leu Leu Tyr Ser Ile Gly Ala Asn Val Ser Ala Glu 
        275                 280                 285             


Lys Val Ser Gln Leu Leu Ser Phe Ala Thr Thr Leu Cys Ser Gln Glu 
    290                 295                 300                 


Ser Ser Thr Leu Gly Leu Pro Asp Phe Pro Leu Asp Ser Leu Ala Ala 
305                 310                 315                 320 


Ala Val Gln Ile Leu Asp Ser Phe Pro Met Met Pro Ile Lys His Ala 
                325                 330                 335     


Ile Gln Trp Leu Tyr Pro Tyr Ser Ile Leu Leu Gly His Glu Gly Lys 
            340                 345                 350         


Met Ala Val Glu Gly Val Leu Lys Arg Phe Glu Leu Gln Asp Ser Gly 
        355                 360                 365             


Ser Ser Leu Leu Pro Lys Glu Ile Val Lys Val Glu Lys Met Met Glu 
    370                 375                 380                 


Asn His Val Ser Gln Ala Ser Val Thr Ile Arg Ile Ala Asp Lys Glu 
385                 390                 395                 400 


Val Thr Ile Lys Val Pro Ala Gly Thr Arg Leu Leu Ser Gln Pro Cys 
                405                 410                 415     


Ala Ser Asp Arg Phe Ile Gln Thr Leu Ser His Lys Gln Leu Gln Ala 
            420                 425                 430         


Glu Met Met Gln Ser His Met Val Lys Asp Ile Cys Leu Ile Gly Gly 
        435                 440                 445             


Lys Gly Cys Gly Lys Thr Val Ile Ala Lys Asn Phe Ala Asp Thr Leu 
    450                 455                 460                 


Gly Tyr Asn Ile Glu Pro Ile Met Leu Tyr Gln Asp Met Thr Ala Arg 
465                 470                 475                 480 


Asp Leu Leu Gln Gln Arg Tyr Thr Leu Pro Asn Gly Asp Thr Ala Trp 
                485                 490                 495     


Arg Ser Ser Pro Leu Val Asn Ala Ala Leu Glu Gly Lys Leu Val Leu 
            500                 505                 510         


Leu Asp Gly Ile His Arg Val Asn Ala Gly Thr Leu Ala Val Leu Gln 
        515                 520                 525             


Arg Leu Ile His Asp Arg Glu Leu Ser Leu Tyr Asp Gly Ser Arg Leu 
    530                 535                 540                 


Leu Arg Glu Asp Arg Tyr Met Arg Leu Lys Glu Glu Leu Gln Leu Ser 
545                 550                 555                 560 


Asp Glu Gln Leu Gln Lys Arg Ser Ile Phe Pro Ile His Pro Ser Phe 
                565                 570                 575     


Arg Ile Ile Ala Leu Ala Glu Pro Pro Val Ile Gly Ser Thr Ala His 
            580                 585                 590         


Gln Trp Leu Gly Pro Glu Phe Leu Thr Met Phe Phe Phe His Tyr Met 
        595                 600                 605             


Lys Pro Leu Val Lys Ser Glu Glu Ile Gln Val Ile Lys Glu Lys Val 
    610                 615                 620                 


Pro Asn Val Pro Gln Glu Ala Leu Asp Lys Leu Leu Ser Phe Thr His 
625                 630                 635                 640 


Lys Leu Arg Glu Thr Gln Asp Pro Thr Ala Gln Ser Leu Ala Ala Ser 
                645                 650                 655     


Leu Ser Thr Arg Gln Leu Leu Arg Ile Ser Arg Arg Leu Ser Gln Tyr 
            660                 665                 670         


Pro Asn Glu Asn Leu His Ser Ala Val Thr Lys Ala Cys Leu Ser Arg 
        675                 680                 685             


Phe Leu Pro Ser Leu Ala Arg Ser Ala Leu Glu Lys Asn Leu Ala Asp 
    690                 695                 700                 


Ala Thr Ile Glu Ile Asn Thr Asp Asp Asn Leu Glu Pro Glu Leu Lys 
705                 710                 715                 720 


Asp Tyr Lys Cys Glu Val Thr Ser Gly Thr Leu Arg Ile Gly Ala Val 
                725                 730                 735     


Ser Ala Pro Ile Tyr Asn Ala His Glu Lys Met Lys Val Pro Asp Val 
            740                 745                 750         


Leu Phe Tyr Asp Asn Ile Gln His Val Ile Val Met Glu Asp Met Leu 
        755                 760                 765             


Lys Asp Phe Leu Leu Gly Glu His Leu Leu Leu Val Gly Asn Gln Gly 
    770                 775                 780                 


Val Gly Lys Asn Lys Ile Val Asp Arg Phe Leu His Leu Leu Asn Arg 
785                 790                 795                 800 


Pro Arg Glu Tyr Ile Gln Leu His Arg Asp Thr Thr Val Gln Thr Leu 
                805                 810                 815     


Thr Leu Gln Pro Ser Val Lys Asp Gly Leu Ile Val Tyr Glu Asp Ser 
            820                 825                 830         


Pro Leu Val Lys Ala Val Lys Leu Gly His Ile Leu Val Val Asp Glu 
        835                 840                 845             


Ala Asp Lys Ala Pro Thr Asn Val Thr Cys Ile Leu Lys Thr Leu Val 
    850                 855                 860                 


Glu Asn Gly Glu Met Ile Leu Ala Asp Gly Arg Arg Ile Val Ala Asn 
865                 870                 875                 880 


Ser Ala Asn Val Asn Gly Arg Glu Asn Val Val Val Ile His Pro Asp 
                885                 890                 895     


Phe Arg Met Ile Val Leu Ala Asn Arg Pro Gly Phe Pro Phe Leu Gly 
            900                 905                 910         


Asn Asp Phe Phe Gly Thr Leu Gly Asp Ile Phe Ser Cys His Ala Val 
        915                 920                 925             


Asp Asn Pro Lys Pro His Ser Glu Leu Glu Met Leu Arg Gln Tyr Gly 
    930                 935                 940                 


Pro Asn Val Pro Glu Pro Ile Leu Gln Lys Leu Val Ala Ala Phe Gly 
945                 950                 955                 960 


Glu Leu Arg Ser Leu Ala Asp Gln Gly Ile Ile Asn Tyr Pro Tyr Ser 
                965                 970                 975     


Thr Arg Glu Val Val Asn Ile Val Lys His Leu Gln Lys Phe Pro Thr 
            980                 985                 990         


Glu Gly Leu Ser Ser Val Val Arg  Asn Val Phe Asp Phe  Asp Ser Tyr 
        995                 1000                 1005             


Asn Asn  Asp Met Arg Glu Ile  Leu Ile Asn Thr Leu  His Lys Tyr 
    1010                 1015                 1020             


Gly Ile  Pro Ile Gly Ala Lys  Pro Thr Ser Val Gln  Leu Ala Lys 
    1025                 1030                 1035             


Glu Leu  Thr Leu Pro Glu Gln  Thr Phe Met Gly Tyr  Trp Thr Ile 
    1040                 1045                 1050             


Gly Gln  Ala Arg Ser Gly Met  Gln Lys Leu Leu Cys  Pro Val Glu 
    1055                 1060                 1065             


Thr His  His Ile Asp Ile Lys  Gly Pro Ala Leu Ile  Asn Ile Gln 
    1070                 1075                 1080             


Glu Tyr  Pro Ile Glu Arg His  Glu Glu Arg Ser Leu  Asn Phe Thr 
    1085                 1090                 1095             


Glu Glu  Cys Ala Ser Trp Arg  Ile Pro Leu Asp Glu  Ile Asn Ile 
    1100                 1105                 1110             


Ile Cys  Asp Ile Ala Thr Ser  His Glu Asn Glu Gln  Asn Thr Leu 
    1115                 1120                 1125             


Tyr Val  Val Thr Cys Asn Pro  Ala Ser Leu Tyr Phe  Met Asn Met 
    1130                 1135                 1140             


Thr Gly  Lys Ser Gly Phe Phe  Val Asp Phe Phe Asp  Ile Phe Pro 
    1145                 1150                 1155             


Arg Thr  Ala Asn Gly Val Trp  His Pro Phe Val Thr  Val Ala Pro 
    1160                 1165                 1170             


Leu Gly  Ser Pro Leu Lys Gly  Gln Val Val Leu His  Glu Gln Gln 
    1175                 1180                 1185             


Ser Asn  Val Ile Leu Leu Leu  Asp Thr Thr Gly Arg  Ala Leu His 
    1190                 1195                 1200             


Arg Leu  Ile Leu Pro Ser Glu  Lys Phe Thr Ser Lys  Lys Pro Phe 
    1205                 1210                 1215             


Trp Trp  Asn Lys Glu Glu Ala  Glu Thr Tyr Lys Met  Cys Lys Glu 
    1220                 1225                 1230             


Phe Ser  His Lys Asn Trp Leu  Val Phe Tyr Lys Glu  Lys Gly Asn 
    1235                 1240                 1245             


Ser Leu  Thr Val Leu Asp Val  Leu Glu Gly Arg Thr  His Thr Ile 
    1250                 1255                 1260             


Ser Leu  Pro Ile Asn Leu Lys  Thr Val Phe Leu Val  Ala Glu Asp 
    1265                 1270                 1275             


Lys Trp  Leu Leu Val Glu Ser  Lys Thr Asn Gln Lys  Tyr Leu Leu 
    1280                 1285                 1290             


Thr Lys  Pro Ala His Ile Glu  Ser Glu Gly Ser Gly  Val Cys Gln 
    1295                 1300                 1305             


Leu Tyr  Val Leu Lys Glu Glu  Pro Pro Ser Thr Gly  Phe Gly Val 
    1310                 1315                 1320             


Thr Gln  Glu Thr Glu Phe Ser  Ile Pro His Lys Ile  Ser Ser Asp 
    1325                 1330                 1335             


Gln Leu  Ser Ser Glu His Leu  Ser Ser Ala Val Glu  Gln Lys Ile 
    1340                 1345                 1350             


Ala Ser  Pro Asn Arg Ile Leu  Ser Asp Glu Lys Asn  Tyr Ala Thr 
    1355                 1360                 1365             


Ile Val  Val Gly Phe Pro Asp  Leu Met Ser Pro Ser  Glu Val Tyr 
    1370                 1375                 1380             


Ser Trp  Lys Arg Pro Ser Ser  Leu His Lys Arg Ser  Gly Thr Asp 
    1385                 1390                 1395             


Thr Ser  Phe Tyr Arg Gly Lys  Lys Lys Arg Gly Thr  Pro Lys Gln 
    1400                 1405                 1410             


Ser Asn  Cys Val Thr Leu Leu  Asp Thr Asn Gln Val  Val Arg Ile 
    1415                 1420                 1425             


Leu Pro  Pro Gly Glu Val Pro  Leu Lys Asp Ile Tyr  Pro Lys Asp 
    1430                 1435                 1440             


Val Thr  Pro Pro Gln Thr Ser  Gly Tyr Ile Glu Val  Thr Asp Leu 
    1445                 1450                 1455             


Gln Ser  Lys Lys Leu Arg Tyr  Ile Pro Ile Pro Arg  Ser Glu Ser 
    1460                 1465                 1470             


Leu Ser  Pro Tyr Thr Thr Trp  Leu Ser Thr Ile Ser  Asp Thr Asp 
    1475                 1480                 1485             


Ala Leu  Leu Ala Glu Trp Asp  Lys Ser Gly Val Val  Thr Val Asp 
    1490                 1495                 1500             


Met Gly  Gly His Ile Arg Leu  Trp Glu Thr Gly Leu  Glu Arg Leu 
    1505                 1510                 1515             


Gln Arg  Ser Leu Met Glu Trp  Arg Asn Met Ile Gly  Gln Asp Asp 
    1520                 1525                 1530             


Arg Asn  Met Gln Ile Thr Ile  Asn Arg Asp Ser Gly  Glu Asp Val 
    1535                 1540                 1545             


Ser Ser  Pro Lys His Gly Lys  Glu Asp Pro Asp Asn  Met Pro His 
    1550                 1555                 1560             


Val Gly  Gly Asn Thr Trp Ala  Gly Gly Thr Gly Gly  Arg Asp Thr 
    1565                 1570                 1575             


Ala Gly  Leu Gly Gly Lys Gly  Gly Pro Tyr Arg Leu  Asp Ala Gly 
    1580                 1585                 1590             


His Thr  Val Tyr Gln Val Ser  Gln Ala Glu Lys Asp  Ala Val Pro 
    1595                 1600                 1605             


Glu Glu  Val Lys Arg Ala Ala  Arg Glu Met Gly Gln  Arg Ala Phe 
    1610                 1615                 1620             


Gln Gln  Arg Leu Lys Glu Ile  Gln Met Ser Glu Tyr  Asp Ala Ala 
    1625                 1630                 1635             


Thr Tyr  Glu Arg Phe Ser Gly  Ala Val Arg Arg Gln  Val His Ser 
    1640                 1645                 1650             


Leu Arg  Ile Ile Leu Asp Asn  Leu Gln Ala Lys Gly  Lys Glu Arg 
    1655                 1660                 1665             


Gln Trp  Leu Arg His Gln Ala  Thr Gly Glu Leu Asp  Asp Ala Lys 
    1670                 1675                 1680             


Ile Ile  Asp Gly Leu Thr Gly  Glu Lys Ala Ile Tyr  Lys Arg Arg 
    1685                 1690                 1695             


Gly Glu  Leu Glu Pro Gln Leu  Gly Ser Pro Gln Gln  Lys Pro Lys 
    1700                 1705                 1710             


Arg Leu  Arg Leu Val Val Asp  Val Ser Gly Ser Met  Tyr Arg Phe 
    1715                 1720                 1725             


Asn Arg  Met Asp Gly Arg Leu  Glu Arg Thr Met Glu  Ala Val Cys 
    1730                 1735                 1740             


Met Val  Met Glu Ala Phe Glu  Asn Tyr Glu Glu Lys  Phe Gln Tyr 
    1745                 1750                 1755             


Asp Ile  Val Gly His Ser Gly  Asp Gly Tyr Asn Ile  Gly Leu Val 
    1760                 1765                 1770             


Pro Met  Asn Lys Ile Pro Lys  Asp Asn Lys Gln Arg  Leu Glu Ile 
    1775                 1780                 1785             


Leu Lys  Thr Met His Ala His  Ser Gln Phe Cys Met  Ser Gly Asp 
    1790                 1795                 1800             


His Thr  Leu Glu Gly Thr Glu  His Ala Ile Lys Glu  Ile Val Lys 
    1805                 1810                 1815             


Glu Glu  Ala Asp Glu Tyr Phe  Val Ile Val Leu Ser  Asp Ala Asn 
    1820                 1825                 1830             


Leu Ser  Arg Tyr Gly Ile His  Pro Ala Lys Phe Ala  Gln Ile Leu 
    1835                 1840                 1845             


Thr Arg  Asp Pro Gln Val Asn  Ala Phe Ala Ile Phe  Ile Gly Ser 
    1850                 1855                 1860             


Leu Gly  Asp Gln Ala Thr Arg  Leu Gln Arg Thr Leu  Pro Ala Gly 
    1865                 1870                 1875             


Arg Ser  Phe Val Ala Met Asp  Thr Lys Asp Ile Pro  Gln Ile Leu 
    1880                 1885                 1890             


Gln Gln  Ile Phe Thr Ser Thr  Met Leu Ser Ser Val  
    1895                 1900                 1905 


<210>  959
<211>  1670
<212>  DNA
<213>  Homo Sapiens

<400>  959
attgagagtg gctctaacaa gtgccatttt tccttgttag ctttcatttc tcagcccttt       60

acaagattaa aatagtctgc agtttaatct ctccaaagct ttacggacag tgattctgtc      120

ctaaacaaga cagtgactcc aggatttctg aagactattg tggaagaagc atccattaag      180

gccaagctat aacatcagaa atggtgaatg aatacaagaa aattcttttg ctgaaaggat      240

ttgagctcat ggatgattat cattttacat caattaagtc cttactggcc tatgatttag      300

gactaactac aaaaatgcaa gaggaataca acagaattaa gattacagat ttgatggaaa      360

aaaagttcca aggcgttgcc tgtctagaca aactaataga acttgccaaa gatatgccat      420

cacttaaaaa ccttgttaac aatcttcgaa aagagaagtc aaaagttgct aagaaaatta      480

aaacacaaga aaaagctcca gtgaaaaaaa taaaccagga agaagtgggt cttgcggcac      540

ctgcacccac cgcaagaaac aaactgacat cggaagcaag agggaggatt cctgtagctc      600

agaaaagaaa aactccaaac aaagaaaaga ctgaagccaa aaggaataag gtgtcccaag      660

agcagagtaa gcccccaggt ccctcaggag ccagcacatc tgcagctgtg gatcatcccc      720

cactacccca gacctcatca tcaactccat ccaacacttc gtttactccg aatcaggaaa      780

cccaggccca acggcaggtg gatgcaagaa gaaatgttcc ccaaaacgac ccagtgacag      840

tggtggtact gaaagcaaca gcgccattta aatacgagtc cccagaaaat gggaaaagca      900

caatgtttca tgctacagtg gccagtaaga ctcaatattt ccatgtgaaa gtcttcgaca      960

tcaacttgaa agagaaattt gtaaggaaga aggtcattac catatctgat tactctgaat     1020

gtaaaggagt aatggaaata aaggaagcat catctgtgtc tgactttaat caaaattttg     1080

aggtcccaaa cagaattatc gaaatagcaa ataaaactcc caagatcagt caactttaca     1140

agcaagcatc tggaacaatg gtgtatgggt tgtttatgtt acaaaagaaa agcgtacaca     1200

agaagaacac aatttatgaa atacaggata atacaggatc catggatgta gtggggagtg     1260

gaaaatggca caatatcaag tgtgagaaag gagataaact tcgactcttc tgccttcaac     1320

tgagaacagt tgaccgcaag ctgaaactgg tgtgtggaag tcacagcttc atcaaggtca     1380

tcaaggccaa gaaaaacaag gaaggaccaa tgaatgttaa ttgaaatatg aaagctgaaa     1440

tgcaacaaac aacttccgct taaaacaatt aagttgttaa taactgtgat tttgtaaatt     1500

tcagtaattc atttaaatga tgtttcagta gatatattct agcatattaa gagcttttat     1560

aactgagtta tagattagtt tgctttctgg aataaaattt tcttcttata ctcttccttt     1620

tttttagata ttacattttg cttttatgac attcacgagg caaaaaaccg                1670


<210>  960
<211>  407
<212>  PRT
<213>  Homo Sapiens

<400>  960

Met Val Asn Glu Tyr Lys Lys Ile Leu Leu Leu Lys Gly Phe Glu Leu 
1               5                   10                  15      


Met Asp Asp Tyr His Phe Thr Ser Ile Lys Ser Leu Leu Ala Tyr Asp 
            20                  25                  30          


Leu Gly Leu Thr Thr Lys Met Gln Glu Glu Tyr Asn Arg Ile Lys Ile 
        35                  40                  45              


Thr Asp Leu Met Glu Lys Lys Phe Gln Gly Val Ala Cys Leu Asp Lys 
    50                  55                  60                  


Leu Ile Glu Leu Ala Lys Asp Met Pro Ser Leu Lys Asn Leu Val Asn 
65                  70                  75                  80  


Asn Leu Arg Lys Glu Lys Ser Lys Val Ala Lys Lys Ile Lys Thr Gln 
                85                  90                  95      


Glu Lys Ala Pro Val Lys Lys Ile Asn Gln Glu Glu Val Gly Leu Ala 
            100                 105                 110         


Ala Pro Ala Pro Thr Ala Arg Asn Lys Leu Thr Ser Glu Ala Arg Gly 
        115                 120                 125             


Arg Ile Pro Val Ala Gln Lys Arg Lys Thr Pro Asn Lys Glu Lys Thr 
    130                 135                 140                 


Glu Ala Lys Arg Asn Lys Val Ser Gln Glu Gln Ser Lys Pro Pro Gly 
145                 150                 155                 160 


Pro Ser Gly Ala Ser Thr Ser Ala Ala Val Asp His Pro Pro Leu Pro 
                165                 170                 175     


Gln Thr Ser Ser Ser Thr Pro Ser Asn Thr Ser Phe Thr Pro Asn Gln 
            180                 185                 190         


Glu Thr Gln Ala Gln Arg Gln Val Asp Ala Arg Arg Asn Val Pro Gln 
        195                 200                 205             


Asn Asp Pro Val Thr Val Val Val Leu Lys Ala Thr Ala Pro Phe Lys 
    210                 215                 220                 


Tyr Glu Ser Pro Glu Asn Gly Lys Ser Thr Met Phe His Ala Thr Val 
225                 230                 235                 240 


Ala Ser Lys Thr Gln Tyr Phe His Val Lys Val Phe Asp Ile Asn Leu 
                245                 250                 255     


Lys Glu Lys Phe Val Arg Lys Lys Val Ile Thr Ile Ser Asp Tyr Ser 
            260                 265                 270         


Glu Cys Lys Gly Val Met Glu Ile Lys Glu Ala Ser Ser Val Ser Asp 
        275                 280                 285             


Phe Asn Gln Asn Phe Glu Val Pro Asn Arg Ile Ile Glu Ile Ala Asn 
    290                 295                 300                 


Lys Thr Pro Lys Ile Ser Gln Leu Tyr Lys Gln Ala Ser Gly Thr Met 
305                 310                 315                 320 


Val Tyr Gly Leu Phe Met Leu Gln Lys Lys Ser Val His Lys Lys Asn 
                325                 330                 335     


Thr Ile Tyr Glu Ile Gln Asp Asn Thr Gly Ser Met Asp Val Val Gly 
            340                 345                 350         


Ser Gly Lys Trp His Asn Ile Lys Cys Glu Lys Gly Asp Lys Leu Arg 
        355                 360                 365             


Leu Phe Cys Leu Gln Leu Arg Thr Val Asp Arg Lys Leu Lys Leu Val 
    370                 375                 380                 


Cys Gly Ser His Ser Phe Ile Lys Val Ile Lys Ala Lys Lys Asn Lys 
385                 390                 395                 400 


Glu Gly Pro Met Asn Val Asn 
                405         


<210>  961
<211>  3181
<212>  DNA
<213>  Homo Sapiens

<400>  961
agtctgaaga gaggcgggac gcggggtgat aacagctggc tctggtgggc gggcgggagc       60

tggggaggag gagcaggaga ggcccacagg cttcatttgg agtcaggcct ggctgttgct      120

caggtgacca gcttgtgtct ctgggagggc gctgctttcc ccggccaccc ggcgcgatga      180

tccagaatgt cggaaatcac ctgcgacggg gcttggcctc tgtgttctcc aaccgcacat      240

cccggaagtc agccttacgt gcggggaacg acagtgccat ggcagacggc gagggatacc      300

ggaaccccac ggaggtgcag atgagccagc tggtgctgcc ctgccacacc aaccaacgtg      360

gtgagctgag cgtcgggcag ctgctcaagt ggattgacac cacggcttgc ctgtccgcgg      420

agaggcacgc tggctgcccc tgtgtcacag cttccatgga tgacatctat tttgagcaca      480

ccattagtgt tggacaagtg gtgaatatca aggccaaggt gaaccgggcc ttcaactcca      540

gcatggaggt gggcatccag gtggcctcgg aggacctgtg ctctgagaag cagtggaatg      600

tgtgcaaggc cttggccacc ttcgtggccc gccgagagat caccaaggtg aagctgaagc      660

agatcacgcc gcggacagaa gaggagaaga tggagcacag tgtggcggct gagcgccggc      720

gcatgcgcct tgtctatgca gacaccatca aggacctcct ggccaactgc gccattcagg      780

gcgatctgga gagcagagac tgtagccgca tggtgccggc tgagaagacc cgtgtggaga      840

gtgtggagct ggtcctgcct ccccacgcca atcaccaggg caacaccttt gggggccaga      900

tcatggcctg gatggagaat gtggccacca ttgcagccag ccggctctgc cgtgcccacc      960

ctacgctgaa ggccattgaa atgttccact tccgaggccc gtcccaggtc ggcgaccgtc     1020

tggtgctcaa agccatcgtg aacaatgcct tcaaacatag catggaggtg ggcgtgtgcg     1080

tggaggccta tcgccaggag gctgagaccc accggcgcca catcaacagt gcctttatga     1140

cctttgtggt cctggacgca gatgaccagc cccagttgct gccctggatt cggccccagc     1200

ccggcgatgg tgagcggcgg taccgagagg ccagtgccag aaagaagatc cgcctggaca     1260

ggaagtacat cgtgtcctgt aagcagacag aggtgcccct ctccgtcccc tgggacccta     1320

gcaaccaggt gtacctgagc tacaataacg tctcctcctt gaagatgctt gtggccaagg     1380

acaactgggt gctgtcctcg gagatcagtc aggtccgcct gtacactctg gaggatgaca     1440

agttcctctc cttccacatg gagatggtgg tgcatgtgga tgcagcccag gccttcctgc     1500

tgctctcgga cctgcgtcag aggccagagt gggacaagca ctaccggagc gtggagctag     1560

tgcagcaggt agacgaggac gacgccatct accacgtcac cagccctgcc ctcggaggtc     1620

acacaaagcc ccaggacttc gtgatcctgg cctcgaggcg gaagccttgt gacaatgggg     1680

acccctatgt catcgcgctg aggtcggtca cgctgcccac acaccgagag acgccagagt     1740

acagacgcgg agagaccctc tgctcaggct tctgcctctg gcgcgagggg gaccagctga     1800

ccaaggtatc ctactacaac caggccaccc caggtgttct caactatgtg accaccaacg     1860

tggccggcct ctcctctgag ttctacacca ccttcaaggc ttgtgagcag tttctcttgg     1920

acaaccggaa tgatctggcc cccagcctcc agaccctcta gatgccctca gtggccacat     1980

catgcccact cccactccat cctgtcccca aggactcaca tacagtgcct ggagaaagcc     2040

aaagaccttt atttcttcct gcctccccgt gggaagcctc cgccctgagg tccgctggcc     2100

caccacccct gggtgctcag tttctaccaa catgagccag caagtccttg tggtagccct     2160

ggggtagcct gtagtagact cgggtcctgt ccacagccct agctgccagc aatgctgtcc     2220

tcacagaggc atagtcgccc ccagctgggt tgtgctccac tgtgacggtg gcccgggggg     2280

aggatgccag cagcctgcct atggctccag ctgtgctgtg gcccagcagc atggcctgca     2340

tctggaagga cacaggttgc cagagcccct ggcacaactc tagcatatct gtgagcagct     2400

gttccctgta gccactgccc agcacctcct caggccagcc tggtgccaca gtcacgtggg     2460

ggaagacctc agccacagct gtaagcagct ctctgccagc cacatggccg gggaccgaaa     2520

aactcccgtg ggagattttg gccccaaccc acacaggcca atgcaagagg ccaaggctgg     2580

agaggcgtgc cagcaaggcc agggatggcc ggagggctgc gggctccgct atttgcaaat     2640

ggatgcccca gtgtccggga tgtgtggcca gctgctgcag gcaggactcc agcgtcagga     2700

tgttgccact tggagtatga acaatgggca cggggttttc agccacagtt ccctcgaggc     2760

cagtgttcag caggatcatg ccttctgtgt ctggaagagg cggcagaggc aacagtgttt     2820

aggatttggg ttatcataag gtgttaagag tcccttgtta aaggggcagt gggagttatg     2880

gggtcatcaa ggaccttgcc tctctggaat ctgtcaaccc agttttgggc tccaggtgga     2940

tgggttgctt tataaatgtg cctggtgcat gagaaactct tgtttcagct cttggccttt     3000

acccatgact cagcctgggg gctggtgccg gccttgcctg cagcaatgta gctgaggact     3060

ggtctgaagg ccaggagccc tgtgctcttg acatcactgt actccctctc cctccccgca     3120

accctgcccc accttgcatc cagggtatgg tgtaaataaa cctgtgttgc catggcaaca     3180

g                                                                     3181


<210>  962
<211>  594
<212>  PRT
<213>  Homo Sapiens

<400>  962

Met Ile Gln Asn Val Gly Asn His Leu Arg Arg Gly Leu Ala Ser Val 
1               5                   10                  15      


Phe Ser Asn Arg Thr Ser Arg Lys Ser Ala Leu Arg Ala Gly Asn Asp 
            20                  25                  30          


Ser Ala Met Ala Asp Gly Glu Gly Tyr Arg Asn Pro Thr Glu Val Gln 
        35                  40                  45              


Met Ser Gln Leu Val Leu Pro Cys His Thr Asn Gln Arg Gly Glu Leu 
    50                  55                  60                  


Ser Val Gly Gln Leu Leu Lys Trp Ile Asp Thr Thr Ala Cys Leu Ser 
65                  70                  75                  80  


Ala Glu Arg His Ala Gly Cys Pro Cys Val Thr Ala Ser Met Asp Asp 
                85                  90                  95      


Ile Tyr Phe Glu His Thr Ile Ser Val Gly Gln Val Val Asn Ile Lys 
            100                 105                 110         


Ala Lys Val Asn Arg Ala Phe Asn Ser Ser Met Glu Val Gly Ile Gln 
        115                 120                 125             


Val Ala Ser Glu Asp Leu Cys Ser Glu Lys Gln Trp Asn Val Cys Lys 
    130                 135                 140                 


Ala Leu Ala Thr Phe Val Ala Arg Arg Glu Ile Thr Lys Val Lys Leu 
145                 150                 155                 160 


Lys Gln Ile Thr Pro Arg Thr Glu Glu Glu Lys Met Glu His Ser Val 
                165                 170                 175     


Ala Ala Glu Arg Arg Arg Met Arg Leu Val Tyr Ala Asp Thr Ile Lys 
            180                 185                 190         


Asp Leu Leu Ala Asn Cys Ala Ile Gln Gly Asp Leu Glu Ser Arg Asp 
        195                 200                 205             


Cys Ser Arg Met Val Pro Ala Glu Lys Thr Arg Val Glu Ser Val Glu 
    210                 215                 220                 


Leu Val Leu Pro Pro His Ala Asn His Gln Gly Asn Thr Phe Gly Gly 
225                 230                 235                 240 


Gln Ile Met Ala Trp Met Glu Asn Val Ala Thr Ile Ala Ala Ser Arg 
                245                 250                 255     


Leu Cys Arg Ala His Pro Thr Leu Lys Ala Ile Glu Met Phe His Phe 
            260                 265                 270         


Arg Gly Pro Ser Gln Val Gly Asp Arg Leu Val Leu Lys Ala Ile Val 
        275                 280                 285             


Asn Asn Ala Phe Lys His Ser Met Glu Val Gly Val Cys Val Glu Ala 
    290                 295                 300                 


Tyr Arg Gln Glu Ala Glu Thr His Arg Arg His Ile Asn Ser Ala Phe 
305                 310                 315                 320 


Met Thr Phe Val Val Leu Asp Ala Asp Asp Gln Pro Gln Leu Leu Pro 
                325                 330                 335     


Trp Ile Arg Pro Gln Pro Gly Asp Gly Glu Arg Arg Tyr Arg Glu Ala 
            340                 345                 350         


Ser Ala Arg Lys Lys Ile Arg Leu Asp Arg Lys Tyr Ile Val Ser Cys 
        355                 360                 365             


Lys Gln Thr Glu Val Pro Leu Ser Val Pro Trp Asp Pro Ser Asn Gln 
    370                 375                 380                 


Val Tyr Leu Ser Tyr Asn Asn Val Ser Ser Leu Lys Met Leu Val Ala 
385                 390                 395                 400 


Lys Asp Asn Trp Val Leu Ser Ser Glu Ile Ser Gln Val Arg Leu Tyr 
                405                 410                 415     


Thr Leu Glu Asp Asp Lys Phe Leu Ser Phe His Met Glu Met Val Val 
            420                 425                 430         


His Val Asp Ala Ala Gln Ala Phe Leu Leu Leu Ser Asp Leu Arg Gln 
        435                 440                 445             


Arg Pro Glu Trp Asp Lys His Tyr Arg Ser Val Glu Leu Val Gln Gln 
    450                 455                 460                 


Val Asp Glu Asp Asp Ala Ile Tyr His Val Thr Ser Pro Ala Leu Gly 
465                 470                 475                 480 


Gly His Thr Lys Pro Gln Asp Phe Val Ile Leu Ala Ser Arg Arg Lys 
                485                 490                 495     


Pro Cys Asp Asn Gly Asp Pro Tyr Val Ile Ala Leu Arg Ser Val Thr 
            500                 505                 510         


Leu Pro Thr His Arg Glu Thr Pro Glu Tyr Arg Arg Gly Glu Thr Leu 
        515                 520                 525             


Cys Ser Gly Phe Cys Leu Trp Arg Glu Gly Asp Gln Leu Thr Lys Val 
    530                 535                 540                 


Ser Tyr Tyr Asn Gln Ala Thr Pro Gly Val Leu Asn Tyr Val Thr Thr 
545                 550                 555                 560 


Asn Val Ala Gly Leu Ser Ser Glu Phe Tyr Thr Thr Phe Lys Ala Cys 
                565                 570                 575     


Glu Gln Phe Leu Leu Asp Asn Arg Asn Asp Leu Ala Pro Ser Leu Gln 
            580                 585                 590         


Thr Leu 
        


<210>  963
<211>  3013
<212>  DNA
<213>  Homo Sapiens

<400>  963
accctgcaac cgggcagtct ctttctgttt acggagagaa aggggaaatg gaaaagtcgg       60

ggaggcggtg gctggcgtcc gctgcgccgc ccctgggcag gctcagacgc cgtgagtcag      120

gggcagagca gggcggtctg agcgtgcggg cgacgcgggt ctcactcgtc cgctccgctc      180

tggactgcgc gccacgctct ggggtccggc gccctggttc ctgcttctgc cgctgccgcc      240

gccggatccc agtggcccgg cgtgctcggc tcccacaggc ctgcagccag catcgcaccg      300

aaccttcggg gggccgcggc tggagcgctc ggccggcgtg ggagcgccaa ggccgcagat      360

gcaatcttct taccgcgaag aagccagggg aataggtagc cacatcttgt ttgcagataa      420

gaaaggaagc taacgcagta tctgcaaagc caggagtctg actcagtact tttctcactc      480

atgcatacaa agcagctaaa aatgacacag cttatttacc atgcccctga cactgcactg      540

agcactttat gagcttgaac tctgttaatc ctcacgacca cctcatgaga ctctccagaa      600

agagcaacag taatggagta catgagcact ggaagtgaca ataaagaaga gattgattta      660

ttaattaaac atttaaatgt gtctgatgta atagacatta tggaaaatct ttatgcaagt      720

gaagagccag cagtttatga acccagtcta atgaccatgt gtcaagacag taatcaaaac      780

gatgagcgtt ctaagtctct gctgcttagt ggccaagagg taccatggtt gtcatcagtc      840

agatatggaa ctgtggagga tttgcttgct tttgcaaacc atatatccaa cactgcaaag      900

catttttatg gacaacgacc acaggaatct ggaattttat taaacatggt catcactccc      960

caaaatggac gttaccaaat agattccgat gttctcctga tcccctggaa gctgacttac     1020

aggaatattg gttctgattt tattcctcgg ggcgcctttg gaaaggtata cttggcacaa     1080

gatataaaga cgaagaaaag aatggcgtgt aaactgatcc cagtagatca atttaagcca     1140

tctgatgtgg aaatccaggc ttgcttccgg cacgagaaca tcgcagagct gtatggcgca     1200

gtcctgtggg gtgaaactgt ccatctcttt atggaagcag gcgagggagg gtctgttctg     1260

gagaaactgg agagctgtgg accaatgaga gaatttgaaa ttatttgggt gacaaagcat     1320

gttctcaagg gacttgattt tctacactca aagaaagtga tccatcatga tattaaacct     1380

agcaacattg ttttcatgtc cacaaaagct gttttggtgg attttggcct aagtgttcaa     1440

atgaccgaag atgtctattt tcctaaggac ctccgaggaa cagagattta catgagccca     1500

gaggtcatcc tgtgcagggg ccattcaacc aaagcagaca tctacagcct gggggccacg     1560

ctcatccaca tgcagacggg caccccaccc tgggtgaagc gctaccctcg ctcagcctat     1620

ccctcctacc tgtacataat ccacaagcaa gcacctccac tggaagacat tgcagatgac     1680

tgcagtccag ggatgagaga gctgatagaa gcttccctgg agagaaaccc caatcaccgc     1740

ccaagagccg cagacctact aaaacatgag gccctgaacc cgcccagaga ggatcagcca     1800

cgctgtcaga gtctggactc tgccctcttg gagcgcaaga ggctgctgag taggaaggag     1860

ctggaacttc ctgagaacat tgctgattct tcgtgcacag gaagcaccga ggaatctgag     1920

atgctcaaga ggcaacgctc tctctacatc gacctcggcg ctctggctgg ctacttcaat     1980

cttgttcggg gaccaccaac gcttgaatat ggctgaagga tgccatgttt gctctaaatt     2040

aagacagcat tgatctcctg gaggctggtt ctgctgcctc tacacagggg ccctgtacag     2100

tgaatggtgc cattttcgaa ggagcagtgt gacctcctgt gacccatgaa tgtgcctcca     2160

agcggccctg tgtgtttgac atgtgaagct atttgatatg caccaggtct caaggttctc     2220

atttctcagg tgacgtgatt ctaaggcagg aatttgagag ttcacagaag gatcgtgtct     2280

gctgactgtt tcattcactg tgcactttgc tcaaaatttt aaaaatacca atcacaagga     2340

taatagagta gcctaaaatt actattcttg gttcttattt aagtatggaa tattcatttt     2400

actcagaata gctgttttgt gtatattggt gtatattata taactctttg agcctttatt     2460

ggtaaattct ggtatacatt gaattcatta taatttgggt gactagaaca acttgaagat     2520

tgtagcaata agctggacta gtgtcctaaa aatggctaac tgatgaatta gaagccatct     2580

gacagcaggc cactagtgac agtttctttt gtgttcctat ggaaacattt tatactgtac     2640

atgctatgct gaagacattc aaaacgtgat gttttgaatg tggataaaac tgtgtaaacc     2700

acataatttt tgtacatccc aaaggatgag aatgtgacct ttaagaaaaa tgaaaacttt     2760

tgtaaattat tgatgatttt gtaattctta tgactaaatt ttcttttaag catttgtata     2820

ttaaaatagc atactgtgta tgttttatat caaatgcctt catgaatctt tcatacatat     2880

atatatttgt aacattgtaa agtatgtgag tagtcttatg taaagtatgt ttttacatta     2940

tgcaaataaa acccaatact tttgtccaat gtggttggtc aaatcaactg aataaattca     3000

gtattttgcc tta                                                        3013


<210>  964
<211>  467
<212>  PRT
<213>  Homo Sapiens

<400>  964

Met Glu Tyr Met Ser Thr Gly Ser Asp Asn Lys Glu Glu Ile Asp Leu 
1               5                   10                  15      


Leu Ile Lys His Leu Asn Val Ser Asp Val Ile Asp Ile Met Glu Asn 
            20                  25                  30          


Leu Tyr Ala Ser Glu Glu Pro Ala Val Tyr Glu Pro Ser Leu Met Thr 
        35                  40                  45              


Met Cys Gln Asp Ser Asn Gln Asn Asp Glu Arg Ser Lys Ser Leu Leu 
    50                  55                  60                  


Leu Ser Gly Gln Glu Val Pro Trp Leu Ser Ser Val Arg Tyr Gly Thr 
65                  70                  75                  80  


Val Glu Asp Leu Leu Ala Phe Ala Asn His Ile Ser Asn Thr Ala Lys 
                85                  90                  95      


His Phe Tyr Gly Gln Arg Pro Gln Glu Ser Gly Ile Leu Leu Asn Met 
            100                 105                 110         


Val Ile Thr Pro Gln Asn Gly Arg Tyr Gln Ile Asp Ser Asp Val Leu 
        115                 120                 125             


Leu Ile Pro Trp Lys Leu Thr Tyr Arg Asn Ile Gly Ser Asp Phe Ile 
    130                 135                 140                 


Pro Arg Gly Ala Phe Gly Lys Val Tyr Leu Ala Gln Asp Ile Lys Thr 
145                 150                 155                 160 


Lys Lys Arg Met Ala Cys Lys Leu Ile Pro Val Asp Gln Phe Lys Pro 
                165                 170                 175     


Ser Asp Val Glu Ile Gln Ala Cys Phe Arg His Glu Asn Ile Ala Glu 
            180                 185                 190         


Leu Tyr Gly Ala Val Leu Trp Gly Glu Thr Val His Leu Phe Met Glu 
        195                 200                 205             


Ala Gly Glu Gly Gly Ser Val Leu Glu Lys Leu Glu Ser Cys Gly Pro 
    210                 215                 220                 


Met Arg Glu Phe Glu Ile Ile Trp Val Thr Lys His Val Leu Lys Gly 
225                 230                 235                 240 


Leu Asp Phe Leu His Ser Lys Lys Val Ile His His Asp Ile Lys Pro 
                245                 250                 255     


Ser Asn Ile Val Phe Met Ser Thr Lys Ala Val Leu Val Asp Phe Gly 
            260                 265                 270         


Leu Ser Val Gln Met Thr Glu Asp Val Tyr Phe Pro Lys Asp Leu Arg 
        275                 280                 285             


Gly Thr Glu Ile Tyr Met Ser Pro Glu Val Ile Leu Cys Arg Gly His 
    290                 295                 300                 


Ser Thr Lys Ala Asp Ile Tyr Ser Leu Gly Ala Thr Leu Ile His Met 
305                 310                 315                 320 


Gln Thr Gly Thr Pro Pro Trp Val Lys Arg Tyr Pro Arg Ser Ala Tyr 
                325                 330                 335     


Pro Ser Tyr Leu Tyr Ile Ile His Lys Gln Ala Pro Pro Leu Glu Asp 
            340                 345                 350         


Ile Ala Asp Asp Cys Ser Pro Gly Met Arg Glu Leu Ile Glu Ala Ser 
        355                 360                 365             


Leu Glu Arg Asn Pro Asn His Arg Pro Arg Ala Ala Asp Leu Leu Lys 
    370                 375                 380                 


His Glu Ala Leu Asn Pro Pro Arg Glu Asp Gln Pro Arg Cys Gln Ser 
385                 390                 395                 400 


Leu Asp Ser Ala Leu Leu Glu Arg Lys Arg Leu Leu Ser Arg Lys Glu 
                405                 410                 415     


Leu Glu Leu Pro Glu Asn Ile Ala Asp Ser Ser Cys Thr Gly Ser Thr 
            420                 425                 430         


Glu Glu Ser Glu Met Leu Lys Arg Gln Arg Ser Leu Tyr Ile Asp Leu 
        435                 440                 445             


Gly Ala Leu Ala Gly Tyr Phe Asn Leu Val Arg Gly Pro Pro Thr Leu 
    450                 455                 460                 


Glu Tyr Gly 
465         


<210>  965
<211>  1468
<212>  RNA
<213>  Homo Sapiens

<400>  965
ggcaacccac ccagcccccg cacgggaagc gcgccgcaaa aacgcacgcc accgcgccac       60

acgccagagc gaacaccacg cgaaggcgca gccacccgaa gccagccaga cacgaaccca      120

ccgggaggaa cgaacaaccc agagcgccac caagagcgaa caccaccgcg aaggcccgca      180

gccacccgag ccagcaagac cacgaaccca ccagaaggaa gaaacccgaa cacacgaaca      240

cagaaggaac aaaccggaca cacgccaaga acgaaaccac cggagggccc gcggccacga      300

agcaggagac caagaaccca ccaaccagac acaggggaca cagagagagc caacagccag      360

gccagacaag cggcacccag ccgccacaga caaacgcaca cggaagcgca cacgagacac      420

ccgcggaaag gccagagggc aaaagacgca agcagaaacc cgccaccaca ggacggccgg      480

cgaaagcaaa cccaaggaca ggaccggacc cgcagccacc aggcgcgccc acgcagaacc      540

agcaggggcg cgcaccccgc gcggacccgg cgccccggcc ccagggaggc gggagagcag      600

cgggaagggg cgcgcgcacc ccgcgcagcg ggcaaacgca aacgagacac acaggcgacg      660

agggccgcag aagcaagggg acggcgcacc gcacaaggaa aacaaaggcc gccggcggcc      720

agaagcacgg ccacagagcg gggcaacagg cagaagagca ggaaacagga cgccagacca      780

gacaccgaaa ccagagcaac aacacccacc gggccaccga aaggcaccag ggacaacgaa      840

gggagagaca caagcaccaa agcaagggca accaagggac ggacgaggga gagaggcacc      900

agcccaaaca agggacaaaa acagcagaaa acggagaaac aaagaaacgc aaaaaccggc      960

aggaagcccg gagaggacgc aggaaacaag gagacgacgg ggaagaaagc agggaccgga     1020

gggcagggag ggaagagaag acggcggaag gagcacagaa aaaaaaggag acaacagagg     1080

acgaagaagg cagaacaaag ggggaaagaa acaagagggg gagaaaagaa acagcagagc     1140

ccacagggga aaggggaaag gagagcaaga gaacaaggag ccgcaaagca cccgggacac     1200

aagagaagca ccggagagaa aaccgggagg agggggggca gggaaaccca cccaagagcg     1260

ggcaggaaca gcagcggccg aacgaaggac accaggagcg cggggccagg agaagggacc     1320

cagcccccca acgcccgccg agcgccccac cgagagggga agaacaccca agaagcccga     1380

accccacggg gcaacggccc cggaacacaa caaccccccc accgggaaac gaacacgcaa     1440

aaaagccacc gaaaaaaaaa aaaaaaaa                                        1468


<210>  966
<211>  1648
<212>  DNA
<213>  Homo Sapiens

<400>  966
cagagaaggc ttaggctccc gagtcaacag ggcattcacc gcctggggcg cctgagtcat       60

caggacactg ccaggagaca cagaacccta gatgccctgc agaatccttc ctgttacggt      120

ccccctccct gaaacatcct tcattgcaat atttccagga aaggaagggg gctggctcgg      180

aggaagagag gtggggaggt gatcagggtt cacagaggag ggaactgaat gacatcccag      240

gattacataa actgtcagag gcagccgaag agttcacaag tgtgaagcct ggaagccggc      300

gggtgccgct gtgtaggaaa gaagctaaag cacttccaga gcctgtccgg agctcagagg      360

ttcggaagac ttatcgacca tggagcgcgc gtcctgcttg ttgctgctgc tgctgccgct      420

ggtgcacgtc tctgcgacca cgccagaacc ttgtgagctg gacgatgaag atttccgctg      480

cgtctgcaac ttctccgaac ctcagcccga ctggtccgaa gccttccagt gtgtgtctgc      540

agtagaggtg gagatccatg ccggcggtct caacctagag ccgtttctaa agcgcgtcga      600

tgcggacgcc gacccgcggc agtatgctga cacggtcaag gctctccgcg tgcggcggct      660

cacagtggga gccgcacagg ttcctgctca gctactggta ggcgccctgc gtgtgctagc      720

gtactcccgc ctcaaggaac tgacgctcga ggacctaaag ataaccggca ccatgcctcc      780

gctgcctctg gaagccacag gacttgcact ttccagcttg cgcctacgca acgtgtcgtg      840

ggcgacaggg cgttcttggc tcgccgagct gcagcagtgg ctcaagccag gcctcaaggt      900

actgagcatt gcccaagcac actcgcctgc cttttcctgc gaacaggttc gcgccttccc      960

ggcccttacc agcctagacc tgtctgacaa tcctggactg ggcgaacgcg gactgatggc     1020

ggctctctgt ccccacaagt tcccggccat ccagaatcta gcgctgcgca acacaggaat     1080

ggagacgccc acaggcgtgt gcgccgcact ggcggcggca ggtgtgcagc cccacagcct     1140

agacctcagc cacaactcgc tgcgcgccac cgtaaaccct agcgctccga gatgcatgtg     1200

gtccagcgcc ctgaactccc tcaatctgtc gttcgctggg ctggaacagg tgcctaaagg     1260

actgccagcc aagctcagag tgctcgatct cagctgcaac agactgaaca gggcgccgca     1320

gcctgacgag ctgcccgagg tggataacct gacactggac gggaatccct tcctggtccc     1380

tggaactgcc ctcccccacg agggctcaat gaactccggc gtggtcccag cctgtgcacg     1440

ttcgaccctg tcggtggggg tgtcgggaac cctggtgctg ctccaagggg cccggggctt     1500

tgcctaagat ccaagacaga ataatgaatg gactcaaact gccttggctt caggggagtc     1560

ccgtcaggac gttgaggact tttcgaccaa ttcaaccctt tgccccacct ttattaaaat     1620

cttaaacaac gggtcaaaaa aaaaaaaa                                        1648


<210>  967
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  967

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  968
<211>  5575
<212>  DNA
<213>  Homo Sapiens

<400>  968
gcggccgcgg gcccggcaga aggccgagta ggagggacca cgcgccgggg gccgcgatct       60

ctggcagggg gcggtgtgcc agcggagcac catgcacata ggcgcccagc gccccaacta      120

cccctcccga ggaaaagagg ccggggccgc gctggggcgg cggagagcat gagggaggcc      180

ggggggcggc tcggcttgga gcgctgctag ggagcggtgc gcgccgcaca cccgcctggg      240

cgcggcggag ggcggggagc cgggcaggtc gcgcctgcgg gcggcagccg accgccggga      300

gctgttctga tttccgacgc gcacgctagg ggcccggagc agcccccggc cccggcgcgc      360

cgccgacatg ggcaacgcag ggagcatgga ttcgcagcag accgatttca gggcgcacaa      420

cgtgcctttg aagctgccga tgccagagcc aggtgaactg gaggagcgat ttgccatcgt      480

gctgaatgct atgaacctac ctcctgacaa agccaggtta ctgcggcagt atgataatga      540

gaaaaaatgg gaactgattt gtgatcagga acgattccag gtgaagaatc ctccccatac      600

atacattcaa aagctcaaag gctatctgga tccagctgta accaggaaga aattcagacg      660

gcgtgttcaa gaatctacac aagtgctaag agaactggaa atttctttga gaactaacca      720

cattggatgg gtcagagaat ttctgaatga agaaaacaaa ggtcttgatg ttctagtgga      780

atatctctca tttgcacagt acgcggtaac ttttgacttt gaaagtgtgg agagtactgt      840

ggagagctcg gtggacaaat caaagccctg gagtaggtcc atcgaggacc tgcacagagg      900

gagcaacctg ccctcacctg tgggcaacag tgtctcccgc tctggaagac attctgcact      960

gcgatataat acattgccaa gcagaagaac tctgaaaaat tcaagattag tgagtaagaa     1020

agatgatgtg catgtctgta tcatgtgttt acgtgccatc atgaattatc agtatggttt     1080

caacatggtc atgtctcatc cacacgctgt caatgagatt gcactaagcc tgaacaacaa     1140

gaatcccaga acaaaagccc ttgtcttaga actgttggca gccgtttgtc ttgtcagagg     1200

cgggcatgaa atcattttat cagcatttga taactttaaa gaggtttgtg gagaaaaaca     1260

gcgctttgag aagttgatgg aacatttcag gaatgaagac aataacatag attttatggt     1320

ggcttctatg cagtttatta atattgtagt ccattcagta gaagatatga atttcagagt     1380

tcacctgcag tatgaattta ccaaattagg cctggacgaa tacttggaca agctgaaaca     1440

cactgagagt gacaagcttc aagtccagat ccaggcttac ctggacaatg tttttgatgt     1500

aggagctcta ctggaagatg ctgaaactaa gaatgctgcc ttggagaggg tggaagaact     1560

ggaagaaaac atttctcatt tatctgaaaa actgcaagac acagagaatg aagccatgtc     1620

caagattgtg gaactggaaa agcaactcat gcagaggaac aaggagctgg atgtcgttcg     1680

ggaaatctac aaagatgcaa atactcaagt tcacacatta agaaaaatgg tcaaagaaaa     1740

agaagaagca attcaaagac agtctaccct ggaaaaaaag attcatgagc tagagaaaca     1800

agggaccatt aaaattcaga agaaagggga tggggatatc gccatactgc cagttgtggc     1860

ttctggcaca ttgtccatgg ggtcagaagt ggtagcaggt aactctgtgg gacccacaat     1920

gggggccgct tcctcaggac ccttgccccc tcctccacca ccactgcctc cctcatcaga     1980

cacacctgaa acagtgcaaa atggtccagt aacaccacct atgccaccgc cgccgccgcc     2040

ccctcctcca cctcctcctc ccccaccgcc ccctccgcct cctcctctcc caggccctgc     2100

agctgagact gtaccagctc ctcccttagc acctcccctt ccctctgcac ctccgctgcc     2160

tggaacatct tcacccacag tggttttcaa ctcaggatta gcagctgtga aaattaagaa     2220

gccaatcaag acgaagttca gaatgccagt gtttaactgg gttgctctga agcccaatca     2280

gatcaatggc acagtcttca atgaaattga tgatgagcga attctggagg atttaaatgt     2340

ggatgaattt gaggaaatat tcaagacaaa agcccaagga cctgccattg atctttcttc     2400

aagcaaacag aagataccac agaagggatc aaacaaagtg acattactag aagcaaacag     2460

ggccaaaaat cttgccataa ctttaaggaa agctggaaag actgctgatg aaatatgtaa     2520

agctattcat gtatttgact tgaagacact gcctgtggac tttgtggaat gcttgatgcg     2580

gttcctacca actgagaatg aagtgaaagt gcttcggctc tacgagcggg aaaggaagcc     2640

tctggaaaac ttgtcagatg aagatcggtt catgatgcag tttagtaaaa tcgagaggct     2700

catgcagaag atgaccatca tggccttcat tgggaacttt gctgaaagca ttcagatgct     2760

gactcctcaa ctacatgcga ttatagcagc atctgtctct ataaagtcgt cccaaaaact     2820

caagaaaatt ctggagatca tcttagccct tggaaactac atgaatagca gtaaaagagg     2880

agcagtttat ggatttaaac ttcagagttt agatctgctc ttagatacaa agtcaacaga     2940

cagaaagcaa acactgttgc actatatatc caatgtggtg aaagaaaaat atcaccaagt     3000

gtccctgttt tataatgagc ttcattatgt ggaaaaagct gctgcagtct cccttgagaa     3060

tgttttgctg gatgtcaagg agctccagag gggaatggac ttgaccaaga gagagtacac     3120

catgcatgac cataacacgc tgctgaagga gttcatcctc aacaatgagg ggaagctgaa     3180

gaagctgcag gatgatgcca agatcgcaca ggatgccttt gatgatgttg tgaagtattt     3240

tggagaaaac cccaagacaa caccaccctc tgtcttcttt cctgtctttg tccggtttgt     3300

gaaagcatat aagcaagcag aagaggaaaa tgagctgagg aaaaagcagg aacaagctct     3360

catggaaaaa ctcctagagc aagaagctct gatggagcag caggatccaa agtctccttc     3420

tcataaatca aagaggcagc agcaagagtt aattgcagaa ttaagaagac gacaagttaa     3480

agataacaga catgtatatg agggaaaaga tggtgccatt gaagatatta tcacagatct     3540

tagaaaccaa ccatacagac gagccgatgc ggtgaggaga agcgtcaggc ggcgctttga     3600

tgatcagaac ttgcgttctg ttaatggtgc cgaaataaca atgtgaacct gagactggcc     3660

tgcatgaata cagggtgtgc gtgaatgaaa ctgcccacat gaactttatg tgctacgatt     3720

taactgcagc cttgaacaca cacaaaaata ttcttaaggg ctcagattta gcaaacacgg     3780

aagaatttta aaatgagctc tcctttcaac ccttgttaac aagtgcctaa aaatggaagt     3840

acctgttcag attaatcaaa gcaataggat ttgatttgat taggtatctt tttacaccag     3900

tatgttattt ttaaccaaaa tgtaaagttc ttattaaact cattacctgc cattgtgatt     3960

gtcccatcat ggcccacctg gtttcctgat gttgtaaata acatcaatgc atctgctgtg     4020

ggtcctttgc tgagatgtct tcgaaggaat tttgttttag ccatatccat caactttgta     4080

ttttacttgc aatttggaag aaggaaagtc acatgatgaa actccttttg tctataacca     4140

ggccctggca aagtgcaaac aggatgcaac tgcagtggca caaaggtcac tcaatccttt     4200

gtttccagtt tcacattcta ctacttctgc gctagagaac gatgctctgt gagaggcatt     4260

cactagtatg aatgtgggga tatagtgtat aagacttatt tgcagtactg tgttcttcag     4320

ctagaggcag ctttttaaat aatgcaagtg tatttattag cattaaaatt aacatctcag     4380

taatcagcat tagcatttct gaggaccatt attaattctg agaacagaaa ttggtgcctt     4440

gcaaggaagt ttactagctc tatcaacaag cattcaaggt tacatctgct agcagagtag     4500

tgttaggaac ctggccttac tctcctctga caatcgcaat tttttcttat tttttataaa     4560

ttcaagaaga tacacttggc atcgtgtatc gaggctaagt ttttcatgca tttcccagac     4620

tacttatgga gaattgcagt ttaagttgct gaaaagtatt aacatggtat taagcttaaa     4680

taatacgtaa tgggactaga tggcccacta agccactgtt attttccttc ctctctggca     4740

gggcacttga tccattccaa agtcaaaaac tggactgaag ctaaatttgt acttttcata     4800

atatacattc tgcttctggc ttatcttctt ggtacatcaa tatattaatt gtaaagttta     4860

ttgtatagta tttaaccgct gaagttccta ttttatgttg tgcttatgtg aaccccttgg     4920

tgaaggtccc ttttccttgg atgtgtagtt atatgatctt tttaaatgta cagatatttt     4980

gctataaaat cggtgcagtt ttttatggtt tttacacttc tctttaattc ccacctaagc     5040

ctctgggtaa tattgtaaat attgttttaa aatgcatcag cctatgctat acaatctgaa     5100

tgttatttta acttatagtt ttttttaata tatatattta actataagga cagtttaggg     5160

aacaagttac ctaccacatt tcactttagt gtacctattt acagaaagat taaactgcca     5220

cctgcgggca cattcccata aatgtgtact ttactttaaa aagaacatgc cacgattttg     5280

tctttctgtg gactcaacat tcacttcgat taaaaatagc aatttgacca agttggactt     5340

ccactacaaa gcagctgttt tccaaagttc aatgctgaca tatatgtata ttaaaataat     5400

tgcctattta ttaatctaca aatagacaac gttggcatgt tcttttctgt ttgtctatta     5460

atgggcctgc ttcttagcaa tattagaatg ttttataaaa gcaattcatg ttacttttct     5520

ggtcttttca tggcatatga gcaaataata aactatttac actactattc tgtaa          5575


<210>  969
<211>  1092
<212>  PRT
<213>  Homo Sapiens

<400>  969

Met Gly Asn Ala Gly Ser Met Asp Ser Gln Gln Thr Asp Phe Arg Ala 
1               5                   10                  15      


His Asn Val Pro Leu Lys Leu Pro Met Pro Glu Pro Gly Glu Leu Glu 
            20                  25                  30          


Glu Arg Phe Ala Ile Val Leu Asn Ala Met Asn Leu Pro Pro Asp Lys 
        35                  40                  45              


Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp Glu Leu Ile 
    50                  55                  60                  


Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His Thr Tyr Ile 
65                  70                  75                  80  


Gln Lys Leu Lys Gly Tyr Leu Asp Pro Ala Val Thr Arg Lys Lys Phe 
                85                  90                  95      


Arg Arg Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Ile 
            100                 105                 110         


Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe Leu Asn Glu 
        115                 120                 125             


Glu Asn Lys Gly Leu Asp Val Leu Val Glu Tyr Leu Ser Phe Ala Gln 
    130                 135                 140                 


Tyr Ala Val Thr Phe Asp Phe Glu Ser Val Glu Ser Thr Val Glu Ser 
145                 150                 155                 160 


Ser Val Asp Lys Ser Lys Pro Trp Ser Arg Ser Ile Glu Asp Leu His 
                165                 170                 175     


Arg Gly Ser Asn Leu Pro Ser Pro Val Gly Asn Ser Val Ser Arg Ser 
            180                 185                 190         


Gly Arg His Ser Ala Leu Arg Tyr Asn Thr Leu Pro Ser Arg Arg Thr 
        195                 200                 205             


Leu Lys Asn Ser Arg Leu Val Ser Lys Lys Asp Asp Val His Val Cys 
    210                 215                 220                 


Ile Met Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly Phe Asn Met 
225                 230                 235                 240 


Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu Ser Leu Asn 
                245                 250                 255     


Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu Leu Ala Ala 
            260                 265                 270         


Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ser Ala Phe Asp 
        275                 280                 285             


Asn Phe Lys Glu Val Cys Gly Glu Lys Gln Arg Phe Glu Lys Leu Met 
    290                 295                 300                 


Glu His Phe Arg Asn Glu Asp Asn Asn Ile Asp Phe Met Val Ala Ser 
305                 310                 315                 320 


Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp Met Asn Phe 
                325                 330                 335     


Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu Asp Glu Tyr 
            340                 345                 350         


Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gln Val Gln Ile 
        355                 360                 365             


Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu Leu Glu Asp 
    370                 375                 380                 


Ala Glu Thr Lys Asn Ala Ala Leu Glu Arg Val Glu Glu Leu Glu Glu 
385                 390                 395                 400 


Asn Ile Ser His Leu Ser Glu Lys Leu Gln Asp Thr Glu Asn Glu Ala 
                405                 410                 415     


Met Ser Lys Ile Val Glu Leu Glu Lys Gln Leu Met Gln Arg Asn Lys 
            420                 425                 430         


Glu Leu Asp Val Val Arg Glu Ile Tyr Lys Asp Ala Asn Thr Gln Val 
        435                 440                 445             


His Thr Leu Arg Lys Met Val Lys Glu Lys Glu Glu Ala Ile Gln Arg 
    450                 455                 460                 


Gln Ser Thr Leu Glu Lys Lys Ile His Glu Leu Glu Lys Gln Gly Thr 
465                 470                 475                 480 


Ile Lys Ile Gln Lys Lys Gly Asp Gly Asp Ile Ala Ile Leu Pro Val 
                485                 490                 495     


Val Ala Ser Gly Thr Leu Ser Met Gly Ser Glu Val Val Ala Gly Asn 
            500                 505                 510         


Ser Val Gly Pro Thr Met Gly Ala Ala Ser Ser Gly Pro Leu Pro Pro 
        515                 520                 525             


Pro Pro Pro Pro Leu Pro Pro Ser Ser Asp Thr Pro Glu Thr Val Gln 
    530                 535                 540                 


Asn Gly Pro Val Thr Pro Pro Met Pro Pro Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly 
                565                 570                 575     


Pro Ala Ala Glu Thr Val Pro Ala Pro Pro Leu Ala Pro Pro Leu Pro 
            580                 585                 590         


Ser Ala Pro Pro Leu Pro Gly Thr Ser Ser Pro Thr Val Val Phe Asn 
        595                 600                 605             


Ser Gly Leu Ala Ala Val Lys Ile Lys Lys Pro Ile Lys Thr Lys Phe 
    610                 615                 620                 


Arg Met Pro Val Phe Asn Trp Val Ala Leu Lys Pro Asn Gln Ile Asn 
625                 630                 635                 640 


Gly Thr Val Phe Asn Glu Ile Asp Asp Glu Arg Ile Leu Glu Asp Leu 
                645                 650                 655     


Asn Val Asp Glu Phe Glu Glu Ile Phe Lys Thr Lys Ala Gln Gly Pro 
            660                 665                 670         


Ala Ile Asp Leu Ser Ser Ser Lys Gln Lys Ile Pro Gln Lys Gly Ser 
        675                 680                 685             


Asn Lys Val Thr Leu Leu Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
    690                 695                 700                 


Thr Leu Arg Lys Ala Gly Lys Thr Ala Asp Glu Ile Cys Lys Ala Ile 
705                 710                 715                 720 


His Val Phe Asp Leu Lys Thr Leu Pro Val Asp Phe Val Glu Cys Leu 
                725                 730                 735     


Met Arg Phe Leu Pro Thr Glu Asn Glu Val Lys Val Leu Arg Leu Tyr 
            740                 745                 750         


Glu Arg Glu Arg Lys Pro Leu Glu Asn Leu Ser Asp Glu Asp Arg Phe 
        755                 760                 765             


Met Met Gln Phe Ser Lys Ile Glu Arg Leu Met Gln Lys Met Thr Ile 
    770                 775                 780                 


Met Ala Phe Ile Gly Asn Phe Ala Glu Ser Ile Gln Met Leu Thr Pro 
785                 790                 795                 800 


Gln Leu His Ala Ile Ile Ala Ala Ser Val Ser Ile Lys Ser Ser Gln 
                805                 810                 815     


Lys Leu Lys Lys Ile Leu Glu Ile Ile Leu Ala Leu Gly Asn Tyr Met 
            820                 825                 830         


Asn Ser Ser Lys Arg Gly Ala Val Tyr Gly Phe Lys Leu Gln Ser Leu 
        835                 840                 845             


Asp Leu Leu Leu Asp Thr Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
    850                 855                 860                 


His Tyr Ile Ser Asn Val Val Lys Glu Lys Tyr His Gln Val Ser Leu 
865                 870                 875                 880 


Phe Tyr Asn Glu Leu His Tyr Val Glu Lys Ala Ala Ala Val Ser Leu 
                885                 890                 895     


Glu Asn Val Leu Leu Asp Val Lys Glu Leu Gln Arg Gly Met Asp Leu 
            900                 905                 910         


Thr Lys Arg Glu Tyr Thr Met His Asp His Asn Thr Leu Leu Lys Glu 
        915                 920                 925             


Phe Ile Leu Asn Asn Glu Gly Lys Leu Lys Lys Leu Gln Asp Asp Ala 
    930                 935                 940                 


Lys Ile Ala Gln Asp Ala Phe Asp Asp Val Val Lys Tyr Phe Gly Glu 
945                 950                 955                 960 


Asn Pro Lys Thr Thr Pro Pro Ser Val Phe Phe Pro Val Phe Val Arg 
                965                 970                 975     


Phe Val Lys Ala Tyr Lys Gln Ala Glu Glu Glu Asn Glu Leu Arg Lys 
            980                 985                 990         


Lys Gln Glu Gln Ala Leu Met Glu  Lys Leu Leu Glu Gln  Glu Ala Leu 
        995                 1000                 1005             


Met Glu  Gln Gln Asp Pro Lys  Ser Pro Ser His Lys  Ser Lys Arg 
    1010                 1015                 1020             


Gln Gln  Gln Glu Leu Ile Ala  Glu Leu Arg Arg Arg  Gln Val Lys 
    1025                 1030                 1035             


Asp Asn  Arg His Val Tyr Glu  Gly Lys Asp Gly Ala  Ile Glu Asp 
    1040                 1045                 1050             


Ile Ile  Thr Asp Leu Arg Asn  Gln Pro Tyr Arg Arg  Ala Asp Ala 
    1055                 1060                 1065             


Val Arg  Arg Ser Val Arg Arg  Arg Phe Asp Asp Gln  Asn Leu Arg 
    1070                 1075                 1080             


Ser Val  Asn Gly Ala Glu Ile  Thr Met 
    1085                 1090         


<210>  970
<211>  11192
<212>  DNA
<213>  Homo Sapiens

<400>  970
gagccggccg cctccgtccg ccttgcttcg gtgcggctgt ccgctacgct gcctccgccc       60

tcgccgcgcg cccccgccag cgggactcca gggaaccccc ggcgccctcg acggggccga      120

ggagtcggga ctcggggagc cggcgctgag ggaggagcct ggtcggagcc gcggagccga      180

aagctccgga gcgtggaggt ggggggccga ggcccctgag ggggccccgc cgcgatgggc      240

aacctggaga gcgccgaggg ggtcccggga gagcccccct ctgtcccgtt gttgctgccg      300

cccggcaaga tgccgatgcc tgagccctgt gagctggagg aaaggttcgc cctggtgctg      360

agctccatga acctgcctcc agacaaggcc cggctcctgc ggcagtatga caatgagaag      420

aaatgggatc tgatctgtga ccaggaacga ttccaggtga agaatcctcc ccacacttac      480

attcagaaac tccagagctt cttggacccc agtgtaactc ggaagaagtt caggaggagg      540

gtgcaggagt caaccaaagt actaagggag ctggagatct ctcttcgcac caaccacatt      600

gggtgggtgc gggaatttct gaatgatgaa aacaaaggcc tggatgtact ggtggattac      660

ctgtcctttg cccagtgttc tgtcatgttt gactttgagg gtctggaaag tggtgacgat      720

ggtgcatttg acaaactccg gtcctggagc aggtcaatcg aggacctgca gccacccagc      780

gccctgtcgg cccccttcac caacagcctc gctcgctctg cgcgccagtc tgtgctccgg      840

tatagcactc tccctgggcg cagggccctg aagaactccc gcctagtgag ccagaaggat      900

gacgtccacg tctgtatcct ttgtctcaga gccatcatga actatcagta cggattcaac      960

ctggtcatgt cccaccccca tgctgtcaat gagattgcac ttagcctcaa taacaagaat     1020

ccaaggacca aagcccttgt cttagagctt ctggcagctg tgtgtttggt gcgaggaggt     1080

cacgaaatca tccttgctgc ctttgacaat ttcaaagagg tatgcaagga gctgcaccgc     1140

tttgagaagc tgatggagta tttccggaat gaggacagca atattgactt catggtggcc     1200

tgcatgcagt tcatcaacat cgtggtgcac tcggtggagg acatgaactt ccgggtccac     1260

ctgcagtatg agtttaccaa gctggggcta gaggagttcc tgcagaagtc aaggcacaca     1320

gagagcgaga agctgcaggt gcagattcag gcatatctgg acaacgtgtt tgatgtcggg     1380

ggtttgttgg aggatgctga gaccaagaat gtagccctgg agaaggtgga ggagttggag     1440

gagcatgtgt cccatctcac agagaagctt ctggacctag agaatgaaaa catgatgcgg     1500

gtggcagaac tagagaagca gctgctacag cgggagaagg aactagagag catcaaggag     1560

acatatgaga acacaagcca ccaggtgcac accctgcgga ggctcattaa agagaaggag     1620

gaggcctttc agcgtcgatg tcatttggag ccaaatgtcc ggggcctgga gtctgtggac     1680

agtgaggccc tggccagagt aggccctgca gagctgagtg agggcatgcc accctccgac     1740

ctggaccttc tggctccagc cccaccccct gaggaggtcc tgcctcttcc tccaccacca     1800

gctccgccct tgccccctcc acctccccca ttaccagaca agtgtccccc agccccacct     1860

ctccctggtg ctgcaccctc tgtggtgttg acagtgggcc tgtcagccat tcgaattaag     1920

aaacctatca agaccaagtt ccggctgcct gtcttcaact ggacagcact gaaacccaac     1980

cagatcagtg gcactgtctt cagcgaactt gatgatgaga agatcttgga ggacctggat     2040

cttgataagt ttgaagaatt attcaagaca aaagcgcagg gccctgccct tgacctcatc     2100

tgctccaaaa acaagacagc gcaaaaagct gccagcaagg tgactctgtt ggaagccaat     2160

cgtgccaaga acctggccat caccctacgc aaggctggcc gctcggctga ggagatctgc     2220

agggccattc atacgtttga cttgcagaca ctacctgtgg acttcgtgga gtgcctgatg     2280

cgcttcctgc ccacagaggc tgaggtaaag ctgctgcggc aatatgagcg ggagcggcag     2340

cccctggagg agttggcagc tgaggaccgc ttcatgctgc tcttcagcaa ggtggaacgg     2400

ttgacccagc gaatggctgg catggccttc ctggggaact tccaggataa cctgcagatg     2460

ctcacaccgc aactcaatgc catcattgcg gcgtccgctt ccgtcaagtc ttcacagaag     2520

ctgaagcaga tgttggagat catacttgca ctggggaact acatgaacag cagcaagcgg     2580

ggagctgtgt atggcttcaa gctccagagc ctggatctgc tgctggatac caagtccact     2640

gaccggaaga tgacactgct tcatttcatc gccttgacag tgaaggagaa atacccagac     2700

ctggctaact tctggcatga gctgcacttt gttgagaagg ctgcagcagt gtccctggag     2760

aacgtgctgc tggacgtgaa ggagctgggc cggggcatgg agctgattcg gcgtgagtgc     2820

agcatccatg acaacagcgt cctccggaac ttcctcagta ccaatgaagg caaactagac     2880

aagctccagc gggacgccaa gacggctgag gaggcctaca atgcagttgt gcgctacttt     2940

ggcgagagtc ccaagactac acctccttct gtattcttcc cagtatttgt ccgattcatt     3000

cgttcttaca aggaagcaga acaagagaat gaagcccgca agaagcagga ggaggtaatg     3060

cgggagaagc agctggctca ggaagccaag aaactggatg ccaagacccc atcccagcgg     3120

aacaagtggc aacagcagga gttaatagca gagttgaggc ggcgccaggc caaggaacac     3180

cggcctgttt atgaggggaa ggatggtacc atcgaggaca tcatcacagg cctccactgc     3240

cagcctatgg ttgttcgcca ccaagccagg agtgctgcac cgcccagtgg tccccctcgg     3300

gctccaggcc cccactgaga ccctctcgga ggcagaagca cttcacccct cagagtccta     3360

caagtccaac cagtggacct ggaattggcc aagggctcag gagagggctg tgttgctctc     3420

tcaaccatgt ccgccccagc tcttgaggct ggatctttct acttgtgcca ctatgggcac     3480

taggtctgta ggtccctggt gcttccagta ctgcactttg cccccaaggt ctttgacttc     3540

atttcctgaa gggtcaccaa gggtcagctc agggctagga aaaaccattt ccagccttag     3600

cctaaacagg gcacatagat ctctcccact agagcccaga gggatgagag gagagagcaa     3660

ctgttctttc tttttttttc ccttcctttt tgcaggccca tggtcagctc tggtctagat     3720

gtatctaggc ttagggagcc ctgggaccct gccagtctca gttcatctct taccaggagc     3780

aaggccctct gaagcatggg ccgtgccagc tgtgccctag tgataagggt aagaggagag     3840

atgtcaggct cactgccctt atttctctgc ccatttcatt ctaggctcac actgtccttg     3900

tcaaggtggg cagaagagca gaggtcttct ctgcaccaac cactctctgc agatggctgg     3960

agaaagggtg tgccaactct tcaccttctt tcctcagcta cggttttttt tttttttttt     4020

ttttttttgg caggggacaa ggagcatggt ggtcttggct atttgcttac cttcccgttt     4080

ctcctctgcc cctggaaggg aatgtggggg cccacttttt tgtacatgta ccacctccct     4140

ttcctcttac tgtacataaa cctcagactc tccccctctc aacaaaggct tgatgcacca     4200

ggcctgactt tgtctcctct ttctgagctt agggggctag ggtggccatt tagtctgacc     4260

tgggctatgg ggatagaaaa gaaatctttg gggcactgca tctgttttgg aggagatgag     4320

atcagaactc tggggaaagg agaaccggct aggtgggctc tagccacaca aagggaagca     4380

ggcctgccat gagacactag tgccctctgc tgggcatgtg tccagtcccc agcctgcccc     4440

agtagcacat ggaaaagagt cactggccat gttataaata ttgttattta aaaaacaaaa     4500

aacaaaacac acgtacatta ggtcctgggt ggaggaagaa gtggtggagc ctcagggcca     4560

gggcaggcag gagcaggcac tgatgctaga gggtgatgac cctgccctct gccacccagg     4620

ctgcgtccaa cagcctgtga ctcttccctg gagacccctt ctctcacact tttatctact     4680

ggcatcaccc accccacatg gcatatacca cccatctctg gtctggggct gagggcaagg     4740

actgcactag tccagggagt aggggaccct tgaacaccaa gagcaacctt gagaggtgcc     4800

aacaatggtg tgctgggggt ggggttactt tagaaaaagt ggacacagac cagactaagg     4860

aagaagtctg aggcagacgg tgagggtggc ccaggagcca tggcctcaca cagacccgag     4920

gcagagaaca gctcattggg tcactggtga tcatccagct gctgtaggag tgtccgccgc     4980

cgcctctcca gctcaccctc actcagctca ctttctgacg tgtcccagcc tgtctgttgg     5040

agcaaaggca cagttcaccc ttagcctgca ctaagggccg tggaagcttg accagcgtgc     5100

tgactggcct agggcccctg cccctcacct tctccttctt gattccaaag cctggggaac     5160

ggttagggag ctctgcctgt tggagctccc tgtccttgtc ctgttcttgt tctttctcat     5220

cgctctcctt gccagctttc tcctcagggt ctgtctcact ctcaggacta ttctgtaaga     5280

gtccagagcc cacctcctca gttcctgtgg atagcctggg aggcaggtag aacagaactc     5340

acaaaatagc aggggcttag gtagaagttc cttcactcac cgacttgtgt cttctcttct     5400

tagttttctt ttttggtttc ttggctttcc gaaggccatg atctagagat agaaaaatcc     5460

ctactaagtc ccaacaggag aaagacaggc tctttttctt tgttctagcc cctctgttca     5520

ttcttcacag gcaggaacct catgctctga ggaagtctaa gtccagtttt ccttctccag     5580

cttcttgctt gggcaggtag aggaagttct ttctacttcc acaggtgcag ccctcccaat     5640

ccagtctacc ctcaaaggag ctggggcttg tggagggcat cctctcagtc tgggacaaca     5700

gttctccagc ttctacgctc acagcaactg cttacctgct ccaagaagat gggaggaagg     5760

ggagccccgt cctccaaggg cagcaccccc actttcaact gaatcaagtg aggaagaggg     5820

ctcagagcct gactctgagg ggttccgcct cctccgcttg gggggccgga gagatggtgg     5880

gggcagctcc tcttcttctg actcagagcc ctgggcagat cagcagatac atgtcagtgc     5940

agaggttctc tgccctccag aagccctcgt ctgggaattc gagagaggag gaggacccag     6000

ggccaaagga atcctcaaac ttccctccaa gggagatatt gtaaggggaa aacaaagtgt     6060

ttatttcccc aaaacaaccc agcttcaccc catgtccctt ctacacgctt actcactgag     6120

ggtgagtggg aacgcttgtg atggtgcttc ttgcctttcc tgccatgctt tcggcctttg     6180

gtgtggaggt gctggcattc agtctgctag aggcagagga agaagggtga ggacagcacc     6240

agacttagcc ccaggaagga tcctacttcc taaaatctgg ctttgcctcc ctttctcaga     6300

ctagagcctt ctgcctatcc cagggatcct caggcctccc cttccttagc tggccaggag     6360

tgccctaagg gtaagaggga ggccactgag gtctctgttg aactggtcta atgagttcaa     6420

gggcctgagg cagatccaga ggacaagcct gcctcacctc cagcacctgt aggaactccc     6480

ggaagagccg gatccgctcc gactccaggg tgatctgctc aaaggctgag tcacacacaa     6540

aacgctcacg gaccttgaac gaggagagca ctgctgatca gactaggccc cactcagcct     6600

ggcctggaca ccgccatgag cacagggcag ggctggggca gagaaaggaa gggaactgga     6660

gctggcccag ggctgtgacg tgactggggt gggccctcag tggtgaagca ccgctgccct     6720

caggcttgag gggtgcttgg ggccaggcta cgctcctgac ctcttcccag gcagtgccta     6780

gctccagagc aggcacagcc tgcctcagca tgcttcgaaa ggcagcttcc ctgcgccgca     6840

tcctgcgtgc ctcctccttc tcccgctccc tctcccgtgc ctctgctttc tccagcagct     6900

gaggaaagaa gggacacgga acagggtcac ccaggagggt ggatgccagg tcccactcag     6960

gcatacctta ggaggtggaa agttagggtc tgggcttcta ccaccatccc ctgaattggg     7020

aatatagtca gtgggacagt gagtgagaag gaatggagca agacacagat gaattagaga     7080

acttcccacg ccccgcccag cccctcacac tattgaaggt cagcttgatg ttgcctgcgt     7140

ccagtgcggc agccctcttg tcaaagctta tgacgtgggc gaagtcctca aaggccgtgt     7200

tcacctccac gcagaagccc cggtcctgtg ggtacagcag tgcatgaagc aggggcacca     7260

cgtgcctgag gccaaagctg gcaggcagag tggtcacatt acagatggtc aagaaggccc     7320

ttgcctctgg aagagatcca caggactgtg gtctgcatta gaaaccaagt tatccaagtc     7380

ctcatcactt gacaattaag cccccatgcc tacccttggt ttggatgtca cacagagctg     7440

aaggggttgg gagatgtctc ccaactgctg attaatgctg agtttctcaa aattaacttt     7500

tgttcctttg gcttaaagct ctggccccag ctgggccctc ctgctgctca gcagtgcttc     7560

catgcattct caatcaacat ttgctggccc ctaccctttg ggtctattta ttgagtgctt     7620

actatgtacc aggtaccatg atgagtgttt cacacattat ctcatttaat cctcttggtt     7680

ctacatttaa gaataggtcc tagtatccta attttacaca gaaggagaaa ccaaggttca     7740

gagaaactag agcacttgcc caaggtctca cagctgatat acggctgggc aagaacccta     7800

ccctgggggg gctctctatc cccaaagtgt ctgctttcaa gcaccacacc cacccagatg     7860

acttagtcca tgggagaaac ggaggccacc aggtgtgcag ctccccacca atactaaaaa     7920

catgtccaca ggccaggctc tatgcttctc atttaggcct cacaacattc cagtgaagca     7980

gaggcttaga aaagtgatct cagttggccc aagatgacat gagtggtaaa tgaagccact     8040

ggagttcaaa gtctggctct cacgtcagtt aagcacaggc cagattccct ttctctccct     8100

ccacatagct ctcacctcct ctggcctttt tgctgatggc agaggtgtgc tcctctttct     8160

tctttccaag ggtacttcct caaccctgct acagtcctta tcaacacagc attcattctc     8220

agggaattga aagctccaag tcacccttgt tactggctcc ttccatcaag cagacacctc     8280

acctaacctg gaacatcctt tccaccatgc tctccccttc atcaagctaa ctacctctgc     8340

tcttttccat tgtttcaaaa cctcttgaaa tgcagcagaa aggaaaagga ataaacattt     8400

attgagaacc tattagacac tttacagatg ttatttaatt ctcacaacct tacctatgaa     8460

ttatccctga tttacaggtg agcaaacagg ctcagagaca cggaacttac ggaggtctca     8520

gagccaataa gcaaccagga gtaatctgac tctaaaacat gtgctgcccc catgccacct     8580

ccatgactct actctcccaa aggttgcttg tgtctactag ccaaatccaa ggccgccttc     8640

tttgtcctca ctcatctggt cctcagtgcc tctaccactt acttcttcaa cactcccctc     8700

tccaggtcac accctctctg accttttatt ctcttgcata tgcatgttcc tgagaacagc     8760

acttagtcct ctttcactac ccaatctgta ctccctcgca atctcatcct tcatctctcc     8820

tgattttcaa acatcctaga ctggatattt cagacactta aaattcaaca gatctcaaga     8880

gaatatattt ctcatgagca tcctccatgg atctccctga cccggatctg tctgcctgtt     8940

ctaagtccag ggctctttgc attatcctat gggatgaaag gcaccatcat ggtctgcctg     9000

gctgtggaaa gcaagaggga ctcctgggct catctgccct ccataggcag gaacccaaat     9060

ggggaaagag gaagggaact gtctaaaaaa gttgctttct caggttgtgt ggagagacag     9120

gactcagtga ggataggccc ctacaggcct atcaaccagc cactctgtgg ctaaaagtta     9180

attgtccaat aaaatttagc tatcccagga taaggcattt ctactttata cgattattct     9240

gttttaaaat atatttgctt tgagagtaat tccccaaata gaattcctat tttctacagc     9300

cttgctcttc ttgttttatc cttatcaata gtgccatcat ccactgccct gacacctctg     9360

attccttcct ttccctccat ttcacaaaat ctatcaattc tacttagtga ctctatccca     9420

ctggtgttga attctccctt ttttttttaa acagcagaaa cagtttatta aaatagaaat     9480

cttatgtaga acctttatgc ataaaaaaga ttcaagctgc ttcacttgaa aacaggaagc     9540

agcaccaaat ccccccatac tcaactccaa cccttgcttg tctcaaggca cctacataga     9600

aacccagagt gtctcagaag aacagctgga gcgctacagc ctgctctctt ctgctgtccc     9660

cactgccccc ggctaggatc acctcctaca agattcctgc acagcctact gacttttctc     9720

cctgctcacc ctcttccatc cctctaaccc agctcctagc atctagtgct tcttggactt     9780

ttgtaccaag tagccccaac agtaggagag aggtctgggg ataagtgaaa tgaatatgac     9840

tatttgaatt accactatca gttttagtat cttgaggctt caagaactgc tctacctagc     9900

accaccacct tccctaagga cataagtacg tactctagac tgaaaggttc tactatacac     9960

catctaatct gatcattccc cggttcctca ttacttacga gagaaaaatc caaatttctt    10020

attttagcat tcaaggcact ttacatgcag ggctctactt ccaagctggg gcatgtggtt    10080

ccagagaaag agaggatacc tcaggacagt atgatacatc ttacctaatg gtaagtaatt    10140

taaaatatta aatttatatt aaataggtaa tatggtgtta aaatgcaaca cctacgtgaa    10200

tttgtaaggc aaaacagtac ttcaaagaaa tgtatatgca gtgagacatt tctagcttta    10260

tttccagatc cctttcaacc caggtaccat ttaatctctg taattaggtg tactctggtg    10320

gaacactcac cattttttag atgaggaaac agggtcagaa aggtcaagtg acctatccaa    10380

ggtcacacaa ctagcaagca gttaagctag acttttactg taggcagtct gcctccagtc    10440

ccgctcctaa ccactgtact gtattatctc ctcaaatgca ttagaatctt cacttccata    10500

aagaaatatg ctctttgttt ttttcttttg gaacacaagg tttagtccat cactcactca    10560

cttttccact tttgataaga tgtaaatatt gagaactatt tctcttctcc agtagaagaa    10620

gagcaacagg ccatgtgtga tggtaaatgg cagctgacac ttgcgacagt atcaagaagg    10680

cactaaggaa tggtgagaag gatgacttgc cctttctaaa gtggcatctc agcttgagtc    10740

tgcagaatgc cttgcaaatc cagctcagta ctgctagata atccatattg acaagagaag    10800

ctaaagattc agattttcta tgtgaagttt cctggtttta aaatgttagc aacaaattcc    10860

aaatttttac agaacactgt acaggccaga aagaacaatc tgtgtgctac cagtttacaa    10920

ttagctatgc ttcttcctcc tcagacctgg catgcccttt ccaccccctt gcctttgctc    10980

ttagtacccc gtgtacactc caacctcttc cacctacaaa tttctaaatg cacagttcaa    11040

atgttagttc ttcagattcc tgtctctgta ataacacttg cccctttgta taacagttct    11100

catgtatatc ttcctattag accatgagct cctgtggtag aaattgtgta ttcattactg    11160

tatccctagt gtgcagtaaa ggatcacagt ag                                  11192


<210>  971
<211>  1027
<212>  PRT
<213>  Homo Sapiens

<400>  971

Met Gly Asn Leu Glu Ser Ala Glu Gly Val Pro Gly Glu Pro Pro Ser 
1               5                   10                  15      


Val Pro Leu Leu Leu Pro Pro Gly Lys Met Pro Met Pro Glu Pro Cys 
            20                  25                  30          


Glu Leu Glu Glu Arg Phe Ala Leu Val Leu Ser Ser Met Asn Leu Pro 
        35                  40                  45              


Pro Asp Lys Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp 
    50                  55                  60                  


Asp Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His 
65                  70                  75                  80  


Thr Tyr Ile Gln Lys Leu Gln Ser Phe Leu Asp Pro Ser Val Thr Arg 
                85                  90                  95      


Lys Lys Phe Arg Arg Arg Val Gln Glu Ser Thr Lys Val Leu Arg Glu 
            100                 105                 110         


Leu Glu Ile Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe 
        115                 120                 125             


Leu Asn Asp Glu Asn Lys Gly Leu Asp Val Leu Val Asp Tyr Leu Ser 
    130                 135                 140                 


Phe Ala Gln Cys Ser Val Met Phe Asp Phe Glu Gly Leu Glu Ser Gly 
145                 150                 155                 160 


Asp Asp Gly Ala Phe Asp Lys Leu Arg Ser Trp Ser Arg Ser Ile Glu 
                165                 170                 175     


Asp Leu Gln Pro Pro Ser Ala Leu Ser Ala Pro Phe Thr Asn Ser Leu 
            180                 185                 190         


Ala Arg Ser Ala Arg Gln Ser Val Leu Arg Tyr Ser Thr Leu Pro Gly 
        195                 200                 205             


Arg Arg Ala Leu Lys Asn Ser Arg Leu Val Ser Gln Lys Asp Asp Val 
    210                 215                 220                 


His Val Cys Ile Leu Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly 
225                 230                 235                 240 


Phe Asn Leu Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu 
                245                 250                 255     


Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu 
            260                 265                 270         


Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ala 
        275                 280                 285             


Ala Phe Asp Asn Phe Lys Glu Val Cys Lys Glu Leu His Arg Phe Glu 
    290                 295                 300                 


Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile Asp Phe Met 
305                 310                 315                 320 


Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp 
                325                 330                 335     


Met Asn Phe Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu 
            340                 345                 350         


Glu Glu Phe Leu Gln Lys Ser Arg His Thr Glu Ser Glu Lys Leu Gln 
        355                 360                 365             


Val Gln Ile Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Gly Leu 
    370                 375                 380                 


Leu Glu Asp Ala Glu Thr Lys Asn Val Ala Leu Glu Lys Val Glu Glu 
385                 390                 395                 400 


Leu Glu Glu His Val Ser His Leu Thr Glu Lys Leu Leu Asp Leu Glu 
                405                 410                 415     


Asn Glu Asn Met Met Arg Val Ala Glu Leu Glu Lys Gln Leu Leu Gln 
            420                 425                 430         


Arg Glu Lys Glu Leu Glu Ser Ile Lys Glu Thr Tyr Glu Asn Thr Ser 
        435                 440                 445             


His Gln Val His Thr Leu Arg Arg Leu Ile Lys Glu Lys Glu Glu Ala 
    450                 455                 460                 


Phe Gln Arg Arg Cys His Leu Glu Pro Asn Val Arg Gly Leu Glu Ser 
465                 470                 475                 480 


Val Asp Ser Glu Ala Leu Ala Arg Val Gly Pro Ala Glu Leu Ser Glu 
                485                 490                 495     


Gly Met Pro Pro Ser Asp Leu Asp Leu Leu Ala Pro Ala Pro Pro Pro 
            500                 505                 510         


Glu Glu Val Leu Pro Leu Pro Pro Pro Pro Ala Pro Pro Leu Pro Pro 
        515                 520                 525             


Pro Pro Pro Pro Leu Pro Asp Lys Cys Pro Pro Ala Pro Pro Leu Pro 
    530                 535                 540                 


Gly Ala Ala Pro Ser Val Val Leu Thr Val Gly Leu Ser Ala Ile Arg 
545                 550                 555                 560 


Ile Lys Lys Pro Ile Lys Thr Lys Phe Arg Leu Pro Val Phe Asn Trp 
                565                 570                 575     


Thr Ala Leu Lys Pro Asn Gln Ile Ser Gly Thr Val Phe Ser Glu Leu 
            580                 585                 590         


Asp Asp Glu Lys Ile Leu Glu Asp Leu Asp Leu Asp Lys Phe Glu Glu 
        595                 600                 605             


Leu Phe Lys Thr Lys Ala Gln Gly Pro Ala Leu Asp Leu Ile Cys Ser 
    610                 615                 620                 


Lys Asn Lys Thr Ala Gln Lys Ala Ala Ser Lys Val Thr Leu Leu Glu 
625                 630                 635                 640 


Ala Asn Arg Ala Lys Asn Leu Ala Ile Thr Leu Arg Lys Ala Gly Arg 
                645                 650                 655     


Ser Ala Glu Glu Ile Cys Arg Ala Ile His Thr Phe Asp Leu Gln Thr 
            660                 665                 670         


Leu Pro Val Asp Phe Val Glu Cys Leu Met Arg Phe Leu Pro Thr Glu 
        675                 680                 685             


Ala Glu Val Lys Leu Leu Arg Gln Tyr Glu Arg Glu Arg Gln Pro Leu 
    690                 695                 700                 


Glu Glu Leu Ala Ala Glu Asp Arg Phe Met Leu Leu Phe Ser Lys Val 
705                 710                 715                 720 


Glu Arg Leu Thr Gln Arg Met Ala Gly Met Ala Phe Leu Gly Asn Phe 
                725                 730                 735     


Gln Asp Asn Leu Gln Met Leu Thr Pro Gln Leu Asn Ala Ile Ile Ala 
            740                 745                 750         


Ala Ser Ala Ser Val Lys Ser Ser Gln Lys Leu Lys Gln Met Leu Glu 
        755                 760                 765             


Ile Ile Leu Ala Leu Gly Asn Tyr Met Asn Ser Ser Lys Arg Gly Ala 
    770                 775                 780                 


Val Tyr Gly Phe Lys Leu Gln Ser Leu Asp Leu Leu Leu Asp Thr Lys 
785                 790                 795                 800 


Ser Thr Asp Arg Lys Met Thr Leu Leu His Phe Ile Ala Leu Thr Val 
                805                 810                 815     


Lys Glu Lys Tyr Pro Asp Leu Ala Asn Phe Trp His Glu Leu His Phe 
            820                 825                 830         


Val Glu Lys Ala Ala Ala Val Ser Leu Glu Asn Val Leu Leu Asp Val 
        835                 840                 845             


Lys Glu Leu Gly Arg Gly Met Glu Leu Ile Arg Arg Glu Cys Ser Ile 
    850                 855                 860                 


His Asp Asn Ser Val Leu Arg Asn Phe Leu Ser Thr Asn Glu Gly Lys 
865                 870                 875                 880 


Leu Asp Lys Leu Gln Arg Asp Ala Lys Thr Ala Glu Glu Ala Tyr Asn 
                885                 890                 895     


Ala Val Val Arg Tyr Phe Gly Glu Ser Pro Lys Thr Thr Pro Pro Ser 
            900                 905                 910         


Val Phe Phe Pro Val Phe Val Arg Phe Ile Arg Ser Tyr Lys Glu Ala 
        915                 920                 925             


Glu Gln Glu Asn Glu Ala Arg Lys Lys Gln Glu Glu Val Met Arg Glu 
    930                 935                 940                 


Lys Gln Leu Ala Gln Glu Ala Lys Lys Leu Asp Ala Lys Thr Pro Ser 
945                 950                 955                 960 


Gln Arg Asn Lys Trp Gln Gln Gln Glu Leu Ile Ala Glu Leu Arg Arg 
                965                 970                 975     


Arg Gln Ala Lys Glu His Arg Pro Val Tyr Glu Gly Lys Asp Gly Thr 
            980                 985                 990         


Ile Glu Asp Ile Ile Thr Gly Leu  His Cys Gln Pro Met  Val Val Arg 
        995                 1000                 1005             


His Gln  Ala Arg Ser Ala Ala  Pro Pro Ser Gly Pro  Pro Arg Ala 
    1010                 1015                 1020             


Pro Gly  Pro His 
    1025         


<210>  972
<211>  2866
<212>  DNA
<213>  Homo Sapiens

<400>  972
gaggggaaga ggatgtgatc atgcgaccgc cagcagaagg gaaattgtga aagcgacctg       60

ctgtagaaaa ggcggcccac agccacctca gcatgcagag gaggcccagc tgctgagagg      120

agttgcctga gagtgacctt tgcatctgcc tgtccagcca gcatggaacc aaagcggatc      180

agagagggct accttgtgaa gaaggggagc gtgttcaata cgtggaaacc catgtgggtt      240

gtattgttag aagatggaat tgaattctat aagaagaaaa gtgacaacag ccccaaagga      300

atgatcccgc tgaaagggag cactctgact agcccttgtc aagactttgg caaaaggatg      360

tttgtgttta agatcactac gaccaaacag caggaccact tcttccaggc agccttcctg      420

gaggagagag atgcctgggt tcgggatatc aagaaggcca ttaaatgcat tgaaggaggc      480

cagaaatttg ccaggaaatc taccaggagg tccattcgac tgccagaaac cattgactta      540

ggtgccttat atttgtccat gaaagacact gaaaaaggaa taaaagaact gaatctagag      600

aaggacaaga agatttttaa tcactgcttc acaggtaact gcgtcattga ttggctggta      660

tccaaccagt ctgttaggaa tcgccaggaa ggcctcatga ttgcttcatc gctgctcaat      720

gaggggtatc tgcagcctgc tggagacatg tccaagagtg cagtggatgg aactgctgaa      780

aaccctttcc tggacaaccc tgatgccttc tactactttc cagacagtgg gttcttctgt      840

gaagagaatt ccagtgatga tgatgtgatt ctgaaagaag aattcagagg ggtcattatc      900

aagcagggat gtttactgaa gcaggggcat agaaggaaaa actggaaagt gaggaagttc      960

atcttgagag aagaccctgc ctacctgcac tactatgacc ctgctggggc agaagatccc     1020

ctgggagcaa ttcacttgag aggctgtgtg gtgacttcag tggagagcaa ctcaaatggc     1080

aggaagagtg aggaagagaa cctttttgag atcatcacag cagatgaagt gcactatttc     1140

ttgcaagcag ccacccccaa ggagcgcaca gagtggatca gagccatcca gatggcctcc     1200

cgaactggga agtaaagaga ctcctgcatt cctcctcccc tcctgaggga agcccatgga     1260

caagctcagt ccaggacctg tccacttctg tgacaaatca acgggaaaca gcccaggggt     1320

gggaagtttt catttgcagg ggggtctgaa tgtaactcac catgtggtgt gcaaggttcc     1380

cctgcattgt attgctcact gcagcccctc tgcccctatc catgaccccc aagcagatat     1440

aacaagctgt gcagcctcag taggctgctt gccctctcca ggcctcaggg cctcttctgg     1500

aaaatgaaga aattcaacta gtagattcct gaggtccccc tagcttaaaa aaaaaaaaaa     1560

tctgccccat gattctaaca ctcgcagtag tgatagtgta tctagttgtt ctgctggtgt     1620

ccttccttgg ctaagtcttg gccttcagtt atcttcaaat gtaccagaac ctgagccaac     1680

gcctccctgt gaaactgttg ctgatctgta gtacagtacc aggaagaaac ctcttttgtt     1740

ctctttagac atcttctact tgctcttggc cttgagatcg tgtaacaaaa tgaaggaggg     1800

ctctcttctt tcttcctcat cctactcaaa aacttcccga gagcagtggt ggttttgagg     1860

gttttgactt ctattacttt tggcagcctg gaaagttgtg tcttctggga aagagacctg     1920

gggaggccag gagtagctga gggtcctttc tgtgccctta aaccgcccag aggagcccta     1980

ttccactctg gttttaggct gatctgagag ggtctccctt tgttcctttc tggagcattt     2040

ctctaacgtt tattacaatt aggaggggga ccccacatct gtgagattct gtttcatttg     2100

aggtttacag aaaaaaaaaa gtggccagat gtgttccccc catgggtgag aggcctgggc     2160

aactgcctgg tgaatgtgtc ttgcggcagc tgcagcaagt ggaggggctg aactactggc     2220

cagctcactg gatgatgggt taatacaaca actgcactgt aaggactcag agccacacag     2280

aacttctgag aggggctgtt agcattgcgc agcatcttca gttctccagt aaatgatatt     2340

gcgttcgtgc ctcagcttta agcacaagta gcagcagctc ctgcttgagt tctgagggca     2400

tcatggccct atgattaacc agagtgatct aacctagact aaaattggga acttatttgc     2460

aatttttgac cctgaccact aactagtgat tcttctccaa aattgagaaa gacagcaccc     2520

attgaagcag atatgtgtgt gaaagtatat ttttcaattc cagattttta attttaaggc     2580

tccaggaaag aaaggagagt agaacatttt tcctcatttt atcaaatcct ctcttgccct     2640

ccctcaattc ccctgtaaca ttcctgaagc tgttcccact cccagatggt tttatcaata     2700

gcctagaggt aaagaactgt ctttttctct gattctttaa taaattatct ttatagaata     2760

tgcacaagtt tttctacact cagtgttaaa gtatttatta atgggaagtc aacttaatgt     2820

tttgaaataa atatatgact ctgtttaatg caaaaaaaaa aaaaaa                    2866


<210>  973
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  973

Met Glu Pro Lys Arg Ile Arg Glu Gly Tyr Leu Val Lys Lys Gly Ser 
1               5                   10                  15      


Val Phe Asn Thr Trp Lys Pro Met Trp Val Val Leu Leu Glu Asp Gly 
            20                  25                  30          


Ile Glu Phe Tyr Lys Lys Lys Ser Asp Asn Ser Pro Lys Gly Met Ile 
        35                  40                  45              


Pro Leu Lys Gly Ser Thr Leu Thr Ser Pro Cys Gln Asp Phe Gly Lys 
    50                  55                  60                  


Arg Met Phe Val Phe Lys Ile Thr Thr Thr Lys Gln Gln Asp His Phe 
65                  70                  75                  80  


Phe Gln Ala Ala Phe Leu Glu Glu Arg Asp Ala Trp Val Arg Asp Ile 
                85                  90                  95      


Lys Lys Ala Ile Lys Cys Ile Glu Gly Gly Gln Lys Phe Ala Arg Lys 
            100                 105                 110         


Ser Thr Arg Arg Ser Ile Arg Leu Pro Glu Thr Ile Asp Leu Gly Ala 
        115                 120                 125             


Leu Tyr Leu Ser Met Lys Asp Thr Glu Lys Gly Ile Lys Glu Leu Asn 
    130                 135                 140                 


Leu Glu Lys Asp Lys Lys Ile Phe Asn His Cys Phe Thr Gly Asn Cys 
145                 150                 155                 160 


Val Ile Asp Trp Leu Val Ser Asn Gln Ser Val Arg Asn Arg Gln Glu 
                165                 170                 175     


Gly Leu Met Ile Ala Ser Ser Leu Leu Asn Glu Gly Tyr Leu Gln Pro 
            180                 185                 190         


Ala Gly Asp Met Ser Lys Ser Ala Val Asp Gly Thr Ala Glu Asn Pro 
        195                 200                 205             


Phe Leu Asp Asn Pro Asp Ala Phe Tyr Tyr Phe Pro Asp Ser Gly Phe 
    210                 215                 220                 


Phe Cys Glu Glu Asn Ser Ser Asp Asp Asp Val Ile Leu Lys Glu Glu 
225                 230                 235                 240 


Phe Arg Gly Val Ile Ile Lys Gln Gly Cys Leu Leu Lys Gln Gly His 
                245                 250                 255     


Arg Arg Lys Asn Trp Lys Val Arg Lys Phe Ile Leu Arg Glu Asp Pro 
            260                 265                 270         


Ala Tyr Leu His Tyr Tyr Asp Pro Ala Gly Ala Glu Asp Pro Leu Gly 
        275                 280                 285             


Ala Ile His Leu Arg Gly Cys Val Val Thr Ser Val Glu Ser Asn Ser 
    290                 295                 300                 


Asn Gly Arg Lys Ser Glu Glu Glu Asn Leu Phe Glu Ile Ile Thr Ala 
305                 310                 315                 320 


Asp Glu Val His Tyr Phe Leu Gln Ala Ala Thr Pro Lys Glu Arg Thr 
                325                 330                 335     


Glu Trp Ile Arg Ala Ile Gln Met Ala Ser Arg Thr Gly Lys 
            340                 345                 350 


<210>  974
<211>  2114
<212>  DNA
<213>  Homo Sapiens

<400>  974
gagagatgtg ggttacaaag ctgccatcta gaggctagag gctcctttct gcagtgtata       60

taatgcaagt ctgcagccag cagagctcac agttgttgca aagtgctcag cactaaggga      120

gccagcgcac agcacagcca ggaaggcgag cgagcccagc cagcccagcc agcccagcca      180

gcccggaggt catttgattg cccgcctcag aacgatggat ctgcatctct tcgactactc      240

agagccaggg aacttctcgg acatcagctg gccatgcaac agcagcgact gcatcgtggt      300

ggacacggtg atgtgtccca acatgcccaa caaaagcgtc ctgctctaca cgctctcctt      360

catttacatt ttcatcttcg tcatcggcat gattgccaac tccgtggtgg tctgggtgaa      420

tatccaggcc aagaccacag gctatgacac gcactgctac atcttgaacc tggccattgc      480

cgacctgtgg gttgtcctca ccatcccagt ctgggtggtc agtctcgtgc agcacaacca      540

gtggcccatg ggcgagctca cgtgcaaagt cacacacctc atcttctcca tcaacctctt      600

cggcagcatt ttcttcctca cgtgcatgag cgtggaccgc tacctctcca tcacctactt      660

caccaacacc cccagcagca ggaagaagat ggtacgccgt gtcgtctgca tcctggtgtg      720

gctgctggcc ttctgcgtgt ctctgcctga cacctactac ctgaagaccg tcacgtctgc      780

gtccaacaat gagacctact gccggtcctt ctaccccgag cacagcatca aggagtggct      840

gatcggcatg gagctggtct ccgttgtctt gggctttgcc gttcccttct ccattatcgc      900

tgtcttctac ttcctgctgg ccagagccat ctcggcgtcc agtgaccagg agaagcacag      960

cagccggaag atcatcttct cctacgtggt ggtcttcctt gtctgctggc tgccctacca     1020

cgtggcggtg ctgctggaca tcttctccat cctgcactac atccctttca cctgccggct     1080

ggagcacgcc ctcttcacgg ccctgcatgt cacacagtgc ctgtcgctgg tgcactgctg     1140

cgtcaaccct gtcctctaca gcttcatcaa tcgcaactac aggtacgagc tgatgaaggc     1200

cttcatcttc aagtactcgg ccaaaacagg gctcaccaag ctcatcgatg cctccagagt     1260

ctcagagacg gagtactctg ccttggagca gagcaccaaa tgatctgccc tggagaggct     1320

ctgggacggg tttacttgtt tttgaacagg gtgatgggcc ctatggtttt ctagagcaaa     1380

gcaaagtagc ttcgggtctt gatgcttgag tagagtgaag aggggagcac gtgccccctg     1440

catccattct ctctttctct tgatgacgca gctgtcattt ggctgtgcgt gctgacagtt     1500

ttgcaacagg cagagctgtg tcgcacagca gtgctgtgcg tcagagccag ctgaggacag     1560

gcttgcctgg acttctgtaa gataggattt tctgtgtttc ctgaattttt tatatggtga     1620

tttgtattta aattttaaga ctttattttc tcactattgg tgtaccttat aaatgtattt     1680

gaaagttaaa tatattttaa atattgtttg ggaggcatag tgctgacata tattcagagt     1740

gttgtagttt taaggttagc gtgacttcag ttttgactaa ggatgacact aattgttagc     1800

tgttttgaaa ttatatatat ataaatatat ataaatatat aaatatatgc cagtcttggc     1860

tgaaatgttt tatttaccat agttttatat ctgtgtggtg ttttgtaccg gcacgggata     1920

tggaacgaaa actgctttgt aatgcagttt gtgacattaa tagtattgta aagttacatt     1980

ttaaaataaa caaaaaactg ttctggactg caaatctgca cacacaacga acagttgcat     2040

ttcagagagt tctctcaatt tgtaagttat ttttttttaa taaagatttt tgtttcctaa     2100

aaaaaaaaaa aaaa                                                       2114


<210>  975
<211>  362
<212>  PRT
<213>  Homo Sapiens

<400>  975

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  976
<211>  1570
<212>  DNA
<213>  Homo Sapiens

<400>  976
gccgagccag ccccttcacc accagccggc cgcgccccgg gaagggaagt ttgtggcgga       60

ggaggttcgt acgggaggag ggggaggcgc ccacgcatct ggggctgact cgctctttcg      120

caaaacgtct gggaggagtc cctggggcca caaaactgcc tccttcctga ggccagaagg      180

agagaagacg tgcagggacc ccgcgcacag gagctgccct cgcgacatgg gtcacccgcc      240

gctgctgccg ctgctgctgc tgctccacac ctgcgtccca gcctcttggg gcctgcggtg      300

catgcagtgt aagaccaacg gggattgccg tgtggaagag tgcgccctgg gacaggacct      360

ctgcaggacc acgatcgtgc gcttgtggga agaaggagaa gagctggagc tggtggagaa      420

aagctgtacc cactcagaga agaccaacag gaccctgagc tatcggactg gcttgaagat      480

caccagcctt accgaggttg tgtgtgggtt agacttgtgc aaccagggca actctggccg      540

ggctgtcacc tattcccgaa gccgttacct cgaatgcatt tcctgtggct catcagacat      600

gagctgtgag aggggccggc accagagcct gcagtgccgc agccctgaag aacagtgcct      660

ggatgtggtg acccactgga tccaggaagg tgaagaaggg cgtccaaagg atgaccgcca      720

cctccgtggc tgtggctacc ttcccggctg cccgggctcc aatggtttcc acaacaacga      780

caccttccac ttcctgaaat gctgcaacac caccaaatgc aacgagggcc caatcctgga      840

gcttgaaaat ctgccgcaga atggccgcca gtgttacagc tgcaagggga acagcaccca      900

tggatgctcc tctgaagaga ctttcctcat tgactgccga ggccccatga atcaatgtct      960

ggtagccacc ggcactcacg aaccgaaaaa ccaaagctat atggtaagag gctgtgcaac     1020

cgcctcaatg tgccaacatg cccacctggg tgacgccttc agcatgaacc acattgatgt     1080

ctcctgctgt actaaaagtg gctgtaacca cccagacctg gatgtccagt accgcagtgg     1140

ggctgctcct cagcctggcc ctgcccatct cagcctcacc atcaccctgc taatgactgc     1200

cagactgtgg ggaggcactc tcctctggac ctaaacctga aatccccctc tctgccctgg     1260

ctggatccgg gggacccctt tgcccttccc tcggctccca gccctacaga cttgctgtgt     1320

gacctcaggc cagtgtgccg acctctctgg gcctcagttt tcccagctat gaaaacagct     1380

atctcacaaa gttgtgtgaa gcagaagaga aaagctggag gaaggccgtg ggccaatggg     1440

agagctcttg ttattattaa tattgttgcc gctgttgtgt tgttgttatt aattaatatt     1500

catattattt attttatact tacataaaga ttttgtacca gtggacaagg ccaaaaaaaa     1560

aaaaaaaaaa                                                            1570


<210>  977
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  977

Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys 
1               5                   10                  15      


Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly 
            20                  25                  30          


Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr 
        35                  40                  45              


Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu 
    50                  55                  60                  


Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg 
65                  70                  75                  80  


Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp 
                85                  90                  95      


Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser 
            100                 105                 110         


Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu 
        115                 120                 125             


Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys 
    130                 135                 140                 


Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro 
145                 150                 155                 160 


Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro 
                165                 170                 175     


Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys 
            180                 185                 190         


Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn 
        195                 200                 205             


Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr 
    210                 215                 220                 


His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro 
225                 230                 235                 240 


Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln 
                245                 250                 255     


Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala 
            260                 265                 270         


His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys 
        275                 280                 285             


Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser 
    290                 295                 300                 


Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr 
305                 310                 315                 320 


Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr 
                325                 330                 335 


<210>  978
<211>  2611
<212>  DNA
<213>  Homo Sapiens

<400>  978
aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa       60

gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat      120

ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca      180

gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca      240

gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa      300

actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat      360

agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga      420

aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga      480

aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc      540

aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag      600

tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc      660

tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa      720

acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca      780

gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct      840

gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg      900

gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga      960

taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat     1020

agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa     1080

gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac     1140

agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt     1200

gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc     1260

tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc     1320

agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga     1380

aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt     1440

gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc     1500

catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa     1560

gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta     1620

catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca     1680

gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca     1740

gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa     1800

agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg     1860

ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag     1920

caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat     1980

gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct     2040

ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga     2100

gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga     2160

tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc     2220

aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac     2280

tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga     2340

tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa     2400

gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa     2460

aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg     2520

tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga     2580

taaaataaaa ttactagaaa gcttgaaagt c                                    2611


<210>  979
<211>  659
<212>  PRT
<213>  Homo Sapiens

<400>  979

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  980
<211>  5155
<212>  DNA
<213>  Homo Sapiens

<400>  980
gtggttgttc ctcccctaaa gcacagcata aatttggaga gatgcatcta aactgcgtgt       60

gggttcgggc tcttttaggt gaatagggct cggcggatcg acttcctcga ttatctccgt      120

gccctggacc cgccccctcc gcctggcgcc aggccgccga gcgccgatcg gctcgatgag      180

cggaggcgct gctgcggcgc tgcggccgac gccgggtccg caccaactgt ctccccctcc      240

cagcttctta cctcggcttc ctactccttc ccccgcccgc ccagcaccgc cagcccggga      300

gagctgccgg gagttccccg ggagcctcag gtggtgacta tcctgttgag aagcaaaaga      360

tactttgcaa gtaaaaaata tgcctcccaa gtttaagcgc cacctcaatg atgatgatgt      420

cacaggttct gtgaaaagtg aaaggagaaa tcttttggaa gatgattcag atgaagaaga      480

ggactttttt ctaaggggac catctggacc aagatttgga cctagaaatg ataaaattaa      540

gcatgttcag aatcaagtgg atgaagttat tgatgtcatg caagaaaata ttacaaaggt      600

aattgagaga ggggagagac tagatgaact acaggacaaa tcagaaagct tatcggataa      660

tgcaacagct tttagcaaca gatccaaaca acttcgaagg caaatgtggt ggcgtggatg      720

caaaataaaa gccatcatgg ctttggttgc tgctatcctt ttgctagtga ttatcattct      780

tatagtcatg aaataccgta cttgatttga tgacagagat cttcattaaa caagatctgg      840

gacagtaata aaagattgct gcataattta aatgaaacct atgtgtatat aactttcaaa      900

acttcttttt caagaaacta agaggcaagt atcacttcaa attggaacgt tgagaatgtc      960

caattatctt ctccctttct aacaaaatgt tcttttaata attatgttta aggcaaagag     1020

aactagcctc tatttttcca tatttcaagg atctaatttg aaactagata cttgccagtt     1080

cattatttgt gtatataaac actgattata atatttcata ttaatatttt aatggcataa     1140

ggacttgcat tattgcatta gggagcgggt catgctgggg gtcaggaagc ctgtgtagag     1200

taccaaatta tatgctgaaa gagatgcata accattctgt caatatttgc agaaatatag     1260

ttcctttcat attacagttg ttttgcaagc aatttccaca tttataggtg taacaaaagc     1320

taaatgttgt aaatgttgtt gccctcaggt ataactaaaa acattccagt aaatatattt     1380

ttgactgtgt aagagaatgt gtagtaattt ttttggcatt ggattatgga aatggaaatt     1440

tttaaacagt gtgaaaaaac atggtatggc atcataaaac tggagataat aaagttattg     1500

aagagtgtca ttggagtatt tgaaaatgac caatatatag ctgccagtca tggtccagtc     1560

tgttttctgt taaactccaa taaagagaga ccagtcagtc ctaatgtgag taaatgaaat     1620

ttacaggtaa cttacttact ccttaatttt attttagtta atagcctcta acttccaact     1680

atctcattta ccaaaagtac aaaaagtagc aaaaccatct attaatactt tgaattttat     1740

atctttgcat ttcctgttca tccttgagga gatgtatgtt gcacaatcaa attttgcatc     1800

agccaacagt aatgagtagt agaaagtcag gaacctatgt gtatatatat atatatatat     1860

atatatatat atatatatat atatacacac aaacacacac acacacacac acacacacgc     1920

acacatatga taatcagtca gtcggtaacc aaatgctaga gagtgaccat taacctaagc     1980

ctgtttttat aatgaaaaaa tgtgttaact ttaaaatatg ccaacctcct tgtgtctttt     2040

aaacaagtca gagtgaaaat acattgtccc ctaaggtgtg gggagaggaa gctttataat     2100

aaaattagtg attctgcaga aacttgtgca ctggatatct tgacaatatg aatataaaac     2160

tccctaaatt aaaaataggg ttaatagaaa ttatcagtat ttaaataggg aaaaatgatt     2220

ttatgtttat tttatttagg ttttatttct ttggtcatct taatgcaaaa tgaataaagc     2280

atagaatctg ggtttggtgt ttttttgtct gtttttaaaa ttctacagga ttattactag     2340

gaggcaaaaa atgctgttta gaatggaaaa aatttgaaga gagaaagcag actgagacac     2400

tcaagacacc tgcaagttat ctaagaagat ctaaatagaa ttactaaatt ttatagtttg     2460

cttagagcat ttagaaggag ataaaggtct tacatactat agtgtatatt gtctttggtc     2520

tctatgctct ttgtaaatgt caattaatat aaacagcatc tgaacagcta ataaatcttt     2580

taagttaaga tacccagaaa aatgagcatt tttagaattt cagtagctaa taattcagga     2640

atggaaatat tttaactgaa tggacagaat cagtcctaac atttgtatgt atgtccttta     2700

tttgaattgg aactaggctc ataagtggtt aattttccat tagttgatgt agaaatctgg     2760

tttctccata atatctacaa gtgaagatga agattacttc tcaaaaagta tccatatttc     2820

cagtgttcct tttaataaaa tatgccactt ttaaataaat aattacaaaa tgtaaaatta     2880

taaaattttt aaatttaaat aataagtaac agtaaaattt tttgacaata tatatgtcac     2940

tgtctttgta atttaaacat attgctgcct gggatatggg taacagaatt atcactcatg     3000

gaactttgta gtagtgatgg cttggtttgt aattcatcat ttcatctttc ttggtcttga     3060

ttaatcctga aatccttaaa atggctggca tggttatgac tttattgtgg taaccttgga     3120

gatataagcc ctcttacgat caaaaacaga agaaaaaaat atattgttca aactgatgcc     3180

aggcctacct ttattccctc ccttaattac tttttttctc attcagctca gatcatcctg     3240

cacttgaaaa atgaagtttt accaccatca aaactatcat tatttaacaa caagtgaaga     3300

tcaacagaaa aattcaagta gctttgcaaa tactagttga tactcagtga aatcacgtca     3360

ctattttgat gcctgaatcc atacctttgt gatttatgtt taattacaga agcctattgc     3420

cttgcagcaa ttttgttgtt ataatactga ttaattggtt actccttctt attataactc     3480

agtaatacct gtggtcattt ggttcctcta tcctgacaaa gttcactgga aattgccctc     3540

agattttata aactggggga tttcttaatt agataaaagt tcattactga agatggaata     3600

ttatataaga tggaggaagg gtaattaata gacatgagat atagaaatac tttgttagcc     3660

ctgctataga ttgcctattg tagtctttct gtgcatttca atagtctgta ttaggaaatt     3720

ataacttcag cacttttgat agcaaaaatt ggcatctttc aattctgtat agtatgtgac     3780

tatcctgtaa atgataatat gtgtacagac tgagaaggca ggaatataaa gtaattgaaa     3840

tctctcattg ccggtatact ctaaaacatg cttgatgcct tgtcagcatc attgcacaca     3900

ttgactctgt atttacatct gtatatacac tatgattaga aaatatgcaa gaaattgttt     3960

ttccatgtta agaacaaatg ccattagaag atgtcccctt aattgtattg tcagagtatt     4020

actatgtcaa ggatgactgt tctgttaacc taattttgtg ttttcacatg gaaatgtgat     4080

tggactccat ttttctgtga gttgagagta agagcataag tcagtttgaa agcatttaca     4140

agtttgtttt agaatgtagt aagggctgaa aggtgctcta cttcttaact tgttttttcc     4200

atgttgtaga caaatgaaat ttgtctaaat gcttttgtct aaaaatgcat ttgtctaaat     4260

gctttagatt gatgtagggt ttagatcctc tttaatactt tgagatagtc ttattctgat     4320

tttttttttc ttctggaaac caagtagaat tagggatggg aatacaaatg catttattct     4380

ggcttctgtt ttattccaag aagcttcttg gaacaaatca gtaggaattg aaaagaaagc     4440

atgaccaacc caattacagg ggataaatgt aagcttgtta aagtaagcac cacaccatgt     4500

ttctgtctcc ccagcaccca gcacagtgct gtgaaccttg gcagatgcta gataaatgtg     4560

tgttgaatga atgtgcctat gaagccacaa agatgccaca tgttagtata tcagtgagag     4620

gtgactccac agtgctctct ggagaagcaa tatgagtgac tgaagagtgg ggccttttgc     4680

ttttgcctgg atataggggt gctcttctac tgtaattggg tgtggaaaaa ctctggcttt     4740

atggtattcc attaggttct tttcatttaa agtagtctta aaatcaaagt atccaatatt     4800

ttaaagccac aaagtagatt acataattag cagagatttt agtcagtaaa atgttagaaa     4860

tcaaactata agaaaattca agtcctttat tttgtgtctt gggtatatgt cattatttta     4920

aattccacac tcccttattt aatcactttg gtaagtgcct ttgatgtttt gaaatgtata     4980

gtgggagatg agcaaatgta aatgtcatgt gccctgttcc ctagcttctc aattcctcat     5040

aaccattttt accagtgttg caaagtttag acctttgtgt taatatcaga agtgtatttg     5100

tagcccctcc atagtgaaca atgaaataaa ctatttcata gaaaacaaaa attaa          5155


<210>  981
<211>  141
<212>  PRT
<213>  Homo Sapiens

<400>  981

Met Pro Pro Lys Phe Lys Arg His Leu Asn Asp Asp Asp Val Thr Gly 
1               5                   10                  15      


Ser Val Lys Ser Glu Arg Arg Asn Leu Leu Glu Asp Asp Ser Asp Glu 
            20                  25                  30          


Glu Glu Asp Phe Phe Leu Arg Gly Pro Ser Gly Pro Arg Phe Gly Pro 
        35                  40                  45              


Arg Asn Asp Lys Ile Lys His Val Gln Asn Gln Val Asp Glu Val Ile 
    50                  55                  60                  


Asp Val Met Gln Glu Asn Ile Thr Lys Val Ile Glu Arg Gly Glu Arg 
65                  70                  75                  80  


Leu Asp Glu Leu Gln Asp Lys Ser Glu Ser Leu Ser Asp Asn Ala Thr 
                85                  90                  95      


Ala Phe Ser Asn Arg Ser Lys Gln Leu Arg Arg Gln Met Trp Trp Arg 
            100                 105                 110         


Gly Cys Lys Ile Lys Ala Ile Met Ala Leu Val Ala Ala Ile Leu Leu 
        115                 120                 125             


Leu Val Ile Ile Ile Leu Ile Val Met Lys Tyr Arg Thr 
    130                 135                 140     


<210>  982
<211>  1956
<212>  DNA
<213>  Homo Sapiens

<400>  982
cttctccctg gtcaaccgct ctgcaaacaa ccatcaatct gatcccacag gcctgagaaa       60

gtctgctctc cagtacctgc tgctgatctg tttcagccga caagaggcac catgaaattg      120

gaattcacgg agaaaaacta caatagcttc gtgctgcaga acctgaacag acagaggaaa      180

cgcaaagagt actgggacat ggccctgagt gtggacaacc acgtcttctt tgcacatcgc      240

aatgtgctgg ctgctgtctc cccactggtg aggagcctca tctccagcaa tgacatgaag      300

accgctgatg agcttttcat caccattgac accagttacc tgagcccggt cacagtggac      360

cagcttctgg actacttcta tagcggcaag gtggtgatct ccgagcaaaa tgtggaggag      420

ctgcttcgtg gggctcagta tttcaacaca ccacgccttc gagttcactg taacgacttc      480

cttattaagt ccatctgccg tgccaactgc ttgcgctacc tcttcttggc tgagctgttt      540

gagctcaaag aggtatcaga cgtagcttac tctggcattc gggacaactt ccactactgg      600

gccagtcctg agggctccat gcacttcatg cgctgtccac ctgttatctt tggccgcctg      660

ctccgtgatg aaaaccttca cgtgctcaat gaagaccagg cgctcagcgc actcatcaat      720

tgggtgtact tccggaagga ggatcgggag aagtatttca agaagttctt caattacatc      780

aatctcaatg ctgtctccaa taagacgctg gtgtttgcca gcaacaagct ggtgggcatg      840

gagaacacct catcccatac aaccctgatt gagagtgtcc tgatggaccg caagcaggag      900

cggccatgca gcctgctggt ctaccagcgg aaaggggccc tgcttgattc cgtggtcatc      960

ctcggtggcc agaaggccca cggccagttc aatgatggag tgtttgctta tatcatccag     1020

gagaacctgt ggatgaagct ctcagacatg ccctatcggg cagcagcact tagtgccacc     1080

tctgctggtc gctacatcta catctctggt ggcaccactg agcagatttc agggctgaag     1140

acagcctggc ggtatgacat ggatgacaac tcctggacca agttgcctga cctgcccatc     1200

gggcttgtct tccacaccat ggtgacctgt ggggggacag tgtactcagt gggcgggagc     1260

attgccccaa ggcggtatgt ctccaacatc tatcgctatg atgagcggaa ggaagtctgg     1320

tgcctggcag gaaagatgag catccccatg gatggcaccg ccgtgatcac taaaggagac     1380

aggcatctgt acattgtcac tggacggtgc ttggtgaaag gttatatctc ccgggtcggg     1440

gtagtggact gctttgacac cagcactggg gacgtggtcc agtgtatcac cttccccatt     1500

gagttcaacc atcggcccct gctctctttc caacaggaca acatcctctg cgtgcacagc     1560

caccggcaga gtgtggaaat caatctgcag aaggtgaagg caagcaagac gaccacctca     1620

gtgcctgtct tgcccaacag ctgccccttg gatgtgtccc atgctatatg ctccattgga     1680

gacagcaagg tgtttgtatg tgggggtgtc accactgcca gcgatgtcca gacaaaggac     1740

tacaccatca atccaaatgc cttcttgctg gaccaaaaga caggcaagtg gaagaccctg     1800

gctcctccac cagaggcact ggactgtcct gcctgctgtc tagccaagct accttgcaag     1860

attcttcaaa ggatttaaac attttaagtg ggagaataag taaatgcatt attattcacg     1920

atttaatgag agaaagagag gaaaaaaaaa aaaaaa                               1956


<210>  983
<211>  588
<212>  PRT
<213>  Homo Sapiens

<400>  983

Met Lys Leu Glu Phe Thr Glu Lys Asn Tyr Asn Ser Phe Val Leu Gln 
1               5                   10                  15      


Asn Leu Asn Arg Gln Arg Lys Arg Lys Glu Tyr Trp Asp Met Ala Leu 
            20                  25                  30          


Ser Val Asp Asn His Val Phe Phe Ala His Arg Asn Val Leu Ala Ala 
        35                  40                  45              


Val Ser Pro Leu Val Arg Ser Leu Ile Ser Ser Asn Asp Met Lys Thr 
    50                  55                  60                  


Ala Asp Glu Leu Phe Ile Thr Ile Asp Thr Ser Tyr Leu Ser Pro Val 
65                  70                  75                  80  


Thr Val Asp Gln Leu Leu Asp Tyr Phe Tyr Ser Gly Lys Val Val Ile 
                85                  90                  95      


Ser Glu Gln Asn Val Glu Glu Leu Leu Arg Gly Ala Gln Tyr Phe Asn 
            100                 105                 110         


Thr Pro Arg Leu Arg Val His Cys Asn Asp Phe Leu Ile Lys Ser Ile 
        115                 120                 125             


Cys Arg Ala Asn Cys Leu Arg Tyr Leu Phe Leu Ala Glu Leu Phe Glu 
    130                 135                 140                 


Leu Lys Glu Val Ser Asp Val Ala Tyr Ser Gly Ile Arg Asp Asn Phe 
145                 150                 155                 160 


His Tyr Trp Ala Ser Pro Glu Gly Ser Met His Phe Met Arg Cys Pro 
                165                 170                 175     


Pro Val Ile Phe Gly Arg Leu Leu Arg Asp Glu Asn Leu His Val Leu 
            180                 185                 190         


Asn Glu Asp Gln Ala Leu Ser Ala Leu Ile Asn Trp Val Tyr Phe Arg 
        195                 200                 205             


Lys Glu Asp Arg Glu Lys Tyr Phe Lys Lys Phe Phe Asn Tyr Ile Asn 
    210                 215                 220                 


Leu Asn Ala Val Ser Asn Lys Thr Leu Val Phe Ala Ser Asn Lys Leu 
225                 230                 235                 240 


Val Gly Met Glu Asn Thr Ser Ser His Thr Thr Leu Ile Glu Ser Val 
                245                 250                 255     


Leu Met Asp Arg Lys Gln Glu Arg Pro Cys Ser Leu Leu Val Tyr Gln 
            260                 265                 270         


Arg Lys Gly Ala Leu Leu Asp Ser Val Val Ile Leu Gly Gly Gln Lys 
        275                 280                 285             


Ala His Gly Gln Phe Asn Asp Gly Val Phe Ala Tyr Ile Ile Gln Glu 
    290                 295                 300                 


Asn Leu Trp Met Lys Leu Ser Asp Met Pro Tyr Arg Ala Ala Ala Leu 
305                 310                 315                 320 


Ser Ala Thr Ser Ala Gly Arg Tyr Ile Tyr Ile Ser Gly Gly Thr Thr 
                325                 330                 335     


Glu Gln Ile Ser Gly Leu Lys Thr Ala Trp Arg Tyr Asp Met Asp Asp 
            340                 345                 350         


Asn Ser Trp Thr Lys Leu Pro Asp Leu Pro Ile Gly Leu Val Phe His 
        355                 360                 365             


Thr Met Val Thr Cys Gly Gly Thr Val Tyr Ser Val Gly Gly Ser Ile 
    370                 375                 380                 


Ala Pro Arg Arg Tyr Val Ser Asn Ile Tyr Arg Tyr Asp Glu Arg Lys 
385                 390                 395                 400 


Glu Val Trp Cys Leu Ala Gly Lys Met Ser Ile Pro Met Asp Gly Thr 
                405                 410                 415     


Ala Val Ile Thr Lys Gly Asp Arg His Leu Tyr Ile Val Thr Gly Arg 
            420                 425                 430         


Cys Leu Val Lys Gly Tyr Ile Ser Arg Val Gly Val Val Asp Cys Phe 
        435                 440                 445             


Asp Thr Ser Thr Gly Asp Val Val Gln Cys Ile Thr Phe Pro Ile Glu 
    450                 455                 460                 


Phe Asn His Arg Pro Leu Leu Ser Phe Gln Gln Asp Asn Ile Leu Cys 
465                 470                 475                 480 


Val His Ser His Arg Gln Ser Val Glu Ile Asn Leu Gln Lys Val Lys 
                485                 490                 495     


Ala Ser Lys Thr Thr Thr Ser Val Pro Val Leu Pro Asn Ser Cys Pro 
            500                 505                 510         


Leu Asp Val Ser His Ala Ile Cys Ser Ile Gly Asp Ser Lys Val Phe 
        515                 520                 525             


Val Cys Gly Gly Val Thr Thr Ala Ser Asp Val Gln Thr Lys Asp Tyr 
    530                 535                 540                 


Thr Ile Asn Pro Asn Ala Phe Leu Leu Asp Gln Lys Thr Gly Lys Trp 
545                 550                 555                 560 


Lys Thr Leu Ala Pro Pro Pro Glu Ala Leu Asp Cys Pro Ala Cys Cys 
                565                 570                 575     


Leu Ala Lys Leu Pro Cys Lys Ile Leu Gln Arg Ile 
            580                 585             


<210>  984
<211>  3809
<212>  DNA
<213>  Homo Sapiens

<400>  984
tctgcccctt ccccccgccc ccgcccgcct cggctcccgc agcgctagtg tgtccgccta       60

gttcagtgtg cgtggagatt aggtccaagc gcccgcccag aggcaggcag tccgcgagcc      120

cagccgccgc tgtcgccgcc agtagcagcc ttcgccagca gcgccgcggc ggaaccgggc      180

gcaggggagc gagcccggcc ccgccagccc agcccagccc agccctactc cctccccacg      240

ccagggcagc agccgttgct cagagagaag gtggaggaag aaatccagac cctagcacgc      300

gcgcaccatc atggaccatt atgattctca gcaaaccaac gattacatgc agccagaaga      360

ggactgggac cgggacctgc tcctggaccc ggcctgggag aagcagcaga gaaagacatt      420

cacggcatgg tgtaactccc acctccggaa ggcggggaca cagatcgaga acatcgaaga      480

ggacttccgg gatggcctga agctcatgct gctgctggag gtcatctcag gtgaacgctt      540

ggccaagcca gagcgaggca agatgagagt gcacaagatc tccaacgtca acaaggccct      600

ggatttcata gccagcaaag gcgtcaaact ggtgtccatc ggagccgaag aaatcgtgga      660

tgggaatgtg aagatgaccc tgggcatgat ctggaccatc atcctgcgct ttgccatcca      720

ggacatctcc gtggaagaga cttcagccaa ggaagggctg ctcctgtggt gtcagagaaa      780

gacagcccct tacaaaaatg tcaacatcca gaacttccac ataagctgga aggatggcct      840

cggcttctgt gctttgatcc accgacaccg gcccgagctg attgactacg ggaagctgcg      900

gaaggatgat ccactcacaa atctgaatac ggcttttgac gtggcagaga agtacctgga      960

catccccaag atgctggatg ccgaagacat cgttggaact gcccgaccgg atgagaaagc     1020

catcatgact tacgtgtcta gcttctacca cgccttctct ggagcccaga aggcggagac     1080

agcagccaat cgcatctgca aggtgttggc cgtcaaccag gagaacgagc agcttatgga     1140

agactacgag aagctggcca gtgatctgtt ggagtggatc cgccgcacaa tcccgtggct     1200

ggagaaccgg gtgcccgaga acaccatgca tgccatgcaa cagaagctgg aggacttccg     1260

ggactaccgg cgcctgcaca agccgcccaa ggtgcaggag aagtgccagc tggagatcaa     1320

cttcaacacg ctgcagacca agctgcggct cagcaaccgg cctgccttca tgccctctga     1380

gggcaggatg gtctcggaca tcaacaatgc ctggggctgc ctggagcagg tggagaaggg     1440

ctatgaggag tggttgctga atgagatccg gaggctggag cgactggacc acctggcaga     1500

gaagttccgg cagaaggcct ccatccacga ggcctggact gacggcaaag aggccatgct     1560

gcgacagaag gactatgaga ccgccaccct ctcggagatc aaggccctgc tcaagaagca     1620

tgaggccttc gagagtgacc tggctgccca ccaggaccgt gtggagcaga ttgccgccat     1680

cgcacaggag ctcaatgagc tggactatta tgactcaccc agtgtcaacg cccgttgcca     1740

aaagatctgt gaccagtggg acaatctggg ggccctaact cagaagcgaa gggaagctct     1800

ggagcggacc gagaaactgc tggagaccat tgaccagctg tacttggagt atgccaagcg     1860

ggctgcaccc ttcaacaact ggatggaggg ggccatggag gacctgcagg acaccttcat     1920

tgtgcacacc attgaggaga tccagggact gaccacagcc catgagcagt tcaaggccac     1980

cctccctgat gccgacaagg agcgcctggc catcctgggc atccacaatg aggtgtccaa     2040

gattgtccag acctaccacg tcaatatggc gggcaccaac ccctacacaa ccatcacgcc     2100

tcaggagatc aatggcaaat gggaccacgt gcggcagctg gtgcctcgga gggaccaagc     2160

tctgacggag gagcatgccc gacagcagca caatgagagg ctacgcaagc agtttggagc     2220

ccaggccaat gtcatcgggc cctggatcca gaccaagatg gaggagatcg ggaggatctc     2280

cattgagatg catgggaccc tggaggacca gctcagccac ctgcggcagt atgagaagag     2340

catcgtcaac tacaagccaa agattgatca gctggagggc gaccaccagc tcatccagga     2400

ggcgctcatc ttcgacaaca agcacaccaa ctacaccatg gagcacatcc gtgtgggctg     2460

ggagcagctg ctcaccacca tcgccaggac catcaatgag gtagagaacc agatcctgac     2520

ccgggatgcc aagggcatca gccaggagca gatgaatgag ttccgggcct ccttcaacca     2580

ctttgaccgg gatcactccg gcacactggg tcccgaggag ttcaaagcct gcctcatcag     2640

cttgggttat gatattggca acgaccccca gaagaagaca ggcatgatgg acacggatga     2700

tttccgcgcc tgcctgatct ccatgggtta caacatggga gaagcagaat ttgcccgcat     2760

catgagcatt gtggacccca accgcctggg ggtagtgaca ttccaggcct tcattgactt     2820

catgtcccgc gagacagccg acacagatac agcagaccaa gtcatggctt ccttcaagat     2880

cctggctggg gacaagaact acattaccat ggacgagctg cgccgcgagc tgccacccga     2940

ccaggctgag tactgcatcg cgcggatggc cccctacacc ggccccgact ccgtgccagg     3000

tgctctggac tacatgtcct tctccacggc gctgtacggc gagagtgacc tctaatccac     3060

cccgcccggc cgccctcgtc ttgtgcgccg tgccctgcct tgcacctccg ccgtcgccca     3120

tctcctgcct gggttcggtt tcagctccca gcctccaccc gggtgagctg gggcccacgt     3180

ggcatcgatc ctccctgccc gcgaagtgac agtttacaaa attattttct gcaaaaaaga     3240

aaaaaaagtt acgttaaaaa ccaaaaaact acatatttta ttatagaaaa agtatttttt     3300

ctccaccaga caaatggaaa aaaagaggaa agattaacta tttgcaccga aatgtcttgt     3360

tttgttgcga cataggaaaa taaccaagca caaagttata ttccatcctt tttactgatt     3420

tttttttctt ctatctgttc catctgctgt attcatttct ccaatctcat gtccattttg     3480

gtgtgggagt cggggtaggg ggtactcttg tcaaaaggca cattggtgca tgtgtgtttg     3540

ctagctcact tgtccatgaa aatattttat gatattaaag aaaatctttt gaaatggctg     3600

ttttttaagg aagagaattt atgtggcttc tcatttttaa atcccctcag aggtgtgact     3660

agtctcttta tcagcacaca cttaaaaaat ttttaatatt gtctattaaa aataggacaa     3720

acttggagag tatggacaac tttgatattg cttggcacag atggtattaa aaaaaccaca     3780

ctcctatgac aaaaaaaaaa aaaaaaaaa                                       3809


<210>  985
<211>  914
<212>  PRT
<213>  Homo Sapiens

<400>  985

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu 
1               5                   10                  15      


Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln 
            20                  25                  30          


Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala 
        35                  40                  45              


Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys 
    50                  55                  60                  


Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro 
65                  70                  75                  80  


Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala 
                85                  90                  95      


Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala 
            100                 105                 110         


Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp 
        115                 120                 125             


Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr 
    130                 135                 140                 


Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro 
145                 150                 155                 160 


Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly 
                165                 170                 175     


Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp 
            180                 185                 190         


Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala 
        195                 200                 205             


Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala 
    210                 215                 220                 


Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr 
225                 230                 235                 240 


Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu 
                245                 250                 255     


Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn 
            260                 265                 270         


Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu 
        275                 280                 285             


Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn 
    290                 295                 300                 


Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg 
305                 310                 315                 320 


Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala 
            340                 345                 350         


Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp 
        355                 360                 365             


Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn 
    370                 375                 380                 


Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg 
385                 390                 395                 400 


Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met 
                405                 410                 415     


Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala 
            420                 425                 430         


Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln 
        435                 440                 445             


Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu 
    450                 455                 460                 


Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys 
465                 470                 475                 480 


Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala 
                485                 490                 495     


Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu 
            500                 505                 510         


Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala 
        515                 520                 525             


Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile 
    530                 535                 540                 


Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp 
545                 550                 555                 560 


Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser 
                565                 570                 575     


Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr 
            580                 585                 590         


Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg 
        595                 600                 605             


Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg 
    610                 615                 620                 


Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala Gln Ala Asn 
625                 630                 635                 640 


Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile 
                645                 650                 655     


Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg 
            660                 665                 670         


Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu 
        675                 680                 685             


Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys 
    690                 695                 700                 


His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu 
705                 710                 715                 720 


Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu 
                725                 730                 735     


Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg 
            740                 745                 750         


Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro 
        755                 760                 765             


Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn 
    770                 775                 780                 


Asp Pro Gln Lys Lys Thr Gly Met Met Asp Thr Asp Asp Phe Arg Ala 
785                 790                 795                 800 


Cys Leu Ile Ser Met Gly Tyr Asn Met Gly Glu Ala Glu Phe Ala Arg 
                805                 810                 815     


Ile Met Ser Ile Val Asp Pro Asn Arg Leu Gly Val Val Thr Phe Gln 
            820                 825                 830         


Ala Phe Ile Asp Phe Met Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala 
        835                 840                 845             


Asp Gln Val Met Ala Ser Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr 
    850                 855                 860                 


Ile Thr Met Asp Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu 
865                 870                 875                 880 


Tyr Cys Ile Ala Arg Met Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro 
                885                 890                 895     


Gly Ala Leu Asp Tyr Met Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser 
            900                 905                 910         


Asp Leu 
        


<210>  986
<211>  2665
<212>  DNA
<213>  Homo Sapiens

<400>  986
aatcgctgac atcatccggg ggcgggcgcc cctgccctgc gggtgactcc gacccctggc       60

tagagggtag gcggcgtgga gcagcgcgcg caagcgaggc caggggaagg tgggcgcagg      120

tgaggggccg aggtgtgcgc aggactttag ccggttgaga aggatcaagc aggcatttgg      180

agcacaggtg tctagaaact tttaaggggc cggttcaaga aggaaaagtt cccttctgct      240

gtgaaactat ttggcaagag gctggagggc ccaatggctg caaaatcgca acccaacatt      300

cccaaagcca agagtctaga tggcgtcacc aatgacagaa ccgcatctca agggcagtgg      360

ggccgtgcct gggaggtgga ctggttttca ctggcgagcg tcatcttcct actgctgttc      420

gcccccttca tcgtctacta cttcatcatg gcttgtgacc agtacagctg cgccctgact      480

ggccctgtgg tggacatcgt caccggacat gctcggctct cggacatctg ggccaagact      540

ccacctataa cgaggaaagc cgcccagctc tataccttgt gggtcacctt ccaggtgctt      600

ctgtacacgt ctctccctga cttctgccat aagtttctac ccggctacgt aggaggcatc      660

caggaggggg ccgtgactcc tgcaggggtt gtgaacaagt atcagatcaa tggcctgcaa      720

gcctggctcc tcacgcacct gctctggttt gcaaacgctc atctcctgtc ctggttctcg      780

cccaccatca tcttcgacaa ctggatccca ctgctgtggt gcgccaacat ccttggctat      840

gccgtctcca ccttcgccat ggtcaagggc tacttcttcc ccaccagcgc cagagactgc      900

aaattcacag gcaatttctt ttacaactac atgatgggca tcgagtttaa ccctcggatc      960

gggaagtggt ttgacttcaa gctgttcttc aatgggcgcc ccgggatcgt cgcctggacc     1020

ctcatcaacc tgtccttcgc agcgaagcag cgggagctcc acagccatgt gaccaatgcc     1080

atggtcctgg tcaacgtcct gcaggccatc tacgtgattg acttcttctg gaacgaaacc     1140

tggtacctga agaccattga catctgccat gaccacttcg ggtggtacct gggctggggc     1200

gactgtgtct ggctgcctta tctttacacg ctgcagggtc tgtacttggt gtaccacccc     1260

gtgcagctgt ccaccccgca cgccgtgggc gtcctgctgc tgggcctggt gggctactac     1320

atcttccggg tggccaacca ccagaaggac ctgttccgcc gcacggatgg gcgctgcctc     1380

atctggggca ggaagcccaa ggtcatcgag tgctcctaca catccgccga tgggcagagg     1440

caccacagca agctgctggt gtcgggcttc tggggcgtgg cccgccactt caactacgtc     1500

ggcgacctga tgggcagcct ggcctactgc ctggcctgtg gcggcggcca cctgctgccc     1560

tacttctaca tcatctacat ggccatcctg ctgacccacc gctgcctccg ggacgagcac     1620

cgctgcgcca gcaagtacgg ccgggactgg gagcgctaca ccgccgcagt gccttaccgc     1680

ctgctgcctg gaatcttcta agggcacgcc ctagggagaa gccctgtggg gctgtcaaga     1740

gcgtgttctg ccaggtccat gggggctggc atcccagctc caactcgagg agcctcagtt     1800

tcctcatctg taaactggag agagcccagc acttggcagg tgtccagtac ctaatcacgc     1860

tctgttcctt gcttttgcct tcaagggaat tccgagtgtc cagcactgcc gtattgccag     1920

cacagacgga ttttctctaa tcagtgtccc tggggcagga ggatgaccca gtcaccttta     1980

ctagtccttt ggagacaatt tacctgtatt aggagcccag gccacgctac actctgccca     2040

cactggtgag caggaggtct tcccacgccc tgtcattagg ctgcatttac tcttgctaaa     2100

taaaagtggg agtggggcgt gcgcgttatc catgtattgc ctttcagctc tagatccccc     2160

tcccctgcct gctctgcagt cgtgggtggg gcccgtgcgc cgtttctcct tggtagcgtg     2220

cacggtgttg aactgggaca ctggggagaa aggggctttc atgtcgtttc cttcctgctc     2280

ctgctgcaca gctgccagga gtgctctgcc tggagtctgc agacctcaga gaggtcccag     2340

caccggctgt ggcctttcag gtgtaggcag gtgggctctg cttcccgatt ccctgtgagc     2400

gcccaccctc tcgaaagaat tttctgcttg ccctatgact gtgcagactc tggctcgagc     2460

aacccgggga acttcaccct caggggcctc ccacaccttc tccagcgagg aggtctcagt     2520

cccagcctcg ggagggcacc tccttttctg tgctttcttc cctgaggcat tcttcctcat     2580

ccctagggtg ttgtgtagaa ctctttttaa actctatgct ccgagtagag ttcatcttta     2640

tattaaactt cccctgttca aataa                                           2665


<210>  987
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  987

Met Ala Ala Lys Ser Gln Pro Asn Ile Pro Lys Ala Lys Ser Leu Asp 
1               5                   10                  15      


Gly Val Thr Asn Asp Arg Thr Ala Ser Gln Gly Gln Trp Gly Arg Ala 
            20                  25                  30          


Trp Glu Val Asp Trp Phe Ser Leu Ala Ser Val Ile Phe Leu Leu Leu 
        35                  40                  45              


Phe Ala Pro Phe Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr 
    50                  55                  60                  


Ser Cys Ala Leu Thr Gly Pro Val Val Asp Ile Val Thr Gly His Ala 
65                  70                  75                  80  


Arg Leu Ser Asp Ile Trp Ala Lys Thr Pro Pro Ile Thr Arg Lys Ala 
                85                  90                  95      


Ala Gln Leu Tyr Thr Leu Trp Val Thr Phe Gln Val Leu Leu Tyr Thr 
            100                 105                 110         


Ser Leu Pro Asp Phe Cys His Lys Phe Leu Pro Gly Tyr Val Gly Gly 
        115                 120                 125             


Ile Gln Glu Gly Ala Val Thr Pro Ala Gly Val Val Asn Lys Tyr Gln 
    130                 135                 140                 


Ile Asn Gly Leu Gln Ala Trp Leu Leu Thr His Leu Leu Trp Phe Ala 
145                 150                 155                 160 


Asn Ala His Leu Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn 
                165                 170                 175     


Trp Ile Pro Leu Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser 
            180                 185                 190         


Thr Phe Ala Met Val Lys Gly Tyr Phe Phe Pro Thr Ser Ala Arg Asp 
        195                 200                 205             


Cys Lys Phe Thr Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu 
    210                 215                 220                 


Phe Asn Pro Arg Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn 
225                 230                 235                 240 


Gly Arg Pro Gly Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala 
                245                 250                 255     


Ala Lys Gln Arg Glu Leu His Ser His Val Thr Asn Ala Met Val Leu 
            260                 265                 270         


Val Asn Val Leu Gln Ala Ile Tyr Val Ile Asp Phe Phe Trp Asn Glu 
        275                 280                 285             


Thr Trp Tyr Leu Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp 
    290                 295                 300                 


Tyr Leu Gly Trp Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu 
305                 310                 315                 320 


Gln Gly Leu Tyr Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro His 
                325                 330                 335     


Ala Val Gly Val Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg 
            340                 345                 350         


Val Ala Asn His Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly Arg Cys 
        355                 360                 365             


Leu Ile Trp Gly Arg Lys Pro Lys Val Ile Glu Cys Ser Tyr Thr Ser 
    370                 375                 380                 


Ala Asp Gly Gln Arg His His Ser Lys Leu Leu Val Ser Gly Phe Trp 
385                 390                 395                 400 


Gly Val Ala Arg His Phe Asn Tyr Val Gly Asp Leu Met Gly Ser Leu 
                405                 410                 415     


Ala Tyr Cys Leu Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr 
            420                 425                 430         


Ile Ile Tyr Met Ala Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu 
        435                 440                 445             


His Arg Cys Ala Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala 
    450                 455                 460                 


Ala Val Pro Tyr Arg Leu Leu Pro Gly Ile Phe 
465                 470                 475 


<210>  988
<211>  1912
<212>  DNA
<213>  Homo Sapiens

<400>  988
cccaggcgcc ccggccttat tccagcctgg ggagcgcctc ggtggggagc acgggacagc       60

gagggaggcc gaggcggggg ccctgggcgc ccgatatctc cgaaccgggg aggcggcccc      120

gattccgaga gccggaacgc agggaaaggc aaggacgggg cggccggcgg aggggcgggc      180

gccgctcatc agccacgcca gtcacgtctg gggccaccgg ctgccttttt cttcctttcc      240

ccctttgctt tcttccccct ccgctgttgg cgagggcaaa gtggccgtgg cggcgccatg      300

cccgggccgg agtgagtgcg cgcgggcgaa aatggcgtac atccagttgg aaccattaaa      360

cgagggtttt ctttctagaa tctctggtct gctgctgtgc agatggacct gccggcactg      420

ctgtcagaag tgctacgagt ccagctgttg ccagtcaagt gaggatgaag ttgaaattct      480

gggacctttc cctgctcaga cccctccctg gctgatggcc agccggagca gtgacaagga      540

tggtgactct gtccacacgg ccagcgaagt cccgctgacc ccacggacca attccccgga      600

tggaagacgc tcgtcctcag acacatccaa gtctacatac agcctgacgc ggaggatttc      660

gagtcttgag tcaagacgtc ccagctctcc actcatcgat attaaaccca tcgagtttgg      720

cgttctcagc gccaagaagg agcccatcca accttcggtg ctcagacgga cctataaccc      780

cgacgactat ttcaggaagt tcgaacccca cctgtactcc ctcgactcca acagcgacga      840

tgtggactct ctgacagacg aggagatcct gtccaagtac cagctgggca tgctgcactt      900

cagcactcag tacgacctgc tgcacaacca cctcaccgtg cgcgtgatcg aggccaggga      960

cctgccacct cccatctccc acgatggctc gcgccaggac atggcgcact ccaaccccta     1020

cgtcaagatc tgtctcctgc cagaccagaa gaactcaaag cagaccgggg tcaaacgcaa     1080

gacccagaag cccgtgtttg aggagcgcta caccttcgag atccccttcc tggaggccca     1140

gaggaggacc ctgctcctga ccgtggtgga ttttgataag ttctcccgcc actgtgtcat     1200

tgggaaagtt tctgtgcctt tgtgtgaagt tgacctggtc aagggcgggc actggtggaa     1260

ggcgctgatt cccagttctc agaatgaagt ggagctgggg gagctgcttc tgtcactgaa     1320

ttatctccca agtgctggca gactgaatgt tgatgtcatt cgagccaagc aacttcttca     1380

gacagatgtg agccaaggtt cagacccctt tgtgaaaatc cagctggtgc atggactcaa     1440

acttgtgaaa accaagaaga cgtccttctt aaggggcaca attgatcctt tctacaatga     1500

atccttcagc ttcaaagttc cccaagaaga actggaaaat gccagcctag tgtttacagt     1560

tttcggccac aacatgaaga gcagcaatga cttcatcggg aggatcgtca ttggccagta     1620

ctcttcaggc ccctctgaga ccaaccactg gaggcgcatg ctcaacacgc accgcacagc     1680

cgtggagcag tggcatagcc tgaggtcccg agctgagtgt gaccgcgtgt ctcctgcctc     1740

cctggaggtg acctgagggc tgcagggaag gcagctttca tttgtttaaa aaaaaaaaaa     1800

aaagacggaa aaaaatgtgt cacatactat tacatccaca cctgcataca cactcgcaac     1860

atgtctacac acgtccacac acacagacac acagataccc caaatcctct ca             1912


<210>  989
<211>  474
<212>  PRT
<213>  Homo Sapiens

<400>  989

Met Ala Tyr Ile Gln Leu Glu Pro Leu Asn Glu Gly Phe Leu Ser Arg 
1               5                   10                  15      


Ile Ser Gly Leu Leu Leu Cys Arg Trp Thr Cys Arg His Cys Cys Gln 
            20                  25                  30          


Lys Cys Tyr Glu Ser Ser Cys Cys Gln Ser Ser Glu Asp Glu Val Glu 
        35                  40                  45              


Ile Leu Gly Pro Phe Pro Ala Gln Thr Pro Pro Trp Leu Met Ala Ser 
    50                  55                  60                  


Arg Ser Ser Asp Lys Asp Gly Asp Ser Val His Thr Ala Ser Glu Val 
65                  70                  75                  80  


Pro Leu Thr Pro Arg Thr Asn Ser Pro Asp Gly Arg Arg Ser Ser Ser 
                85                  90                  95      


Asp Thr Ser Lys Ser Thr Tyr Ser Leu Thr Arg Arg Ile Ser Ser Leu 
            100                 105                 110         


Glu Ser Arg Arg Pro Ser Ser Pro Leu Ile Asp Ile Lys Pro Ile Glu 
        115                 120                 125             


Phe Gly Val Leu Ser Ala Lys Lys Glu Pro Ile Gln Pro Ser Val Leu 
    130                 135                 140                 


Arg Arg Thr Tyr Asn Pro Asp Asp Tyr Phe Arg Lys Phe Glu Pro His 
145                 150                 155                 160 


Leu Tyr Ser Leu Asp Ser Asn Ser Asp Asp Val Asp Ser Leu Thr Asp 
                165                 170                 175     


Glu Glu Ile Leu Ser Lys Tyr Gln Leu Gly Met Leu His Phe Ser Thr 
            180                 185                 190         


Gln Tyr Asp Leu Leu His Asn His Leu Thr Val Arg Val Ile Glu Ala 
        195                 200                 205             


Arg Asp Leu Pro Pro Pro Ile Ser His Asp Gly Ser Arg Gln Asp Met 
    210                 215                 220                 


Ala His Ser Asn Pro Tyr Val Lys Ile Cys Leu Leu Pro Asp Gln Lys 
225                 230                 235                 240 


Asn Ser Lys Gln Thr Gly Val Lys Arg Lys Thr Gln Lys Pro Val Phe 
                245                 250                 255     


Glu Glu Arg Tyr Thr Phe Glu Ile Pro Phe Leu Glu Ala Gln Arg Arg 
            260                 265                 270         


Thr Leu Leu Leu Thr Val Val Asp Phe Asp Lys Phe Ser Arg His Cys 
        275                 280                 285             


Val Ile Gly Lys Val Ser Val Pro Leu Cys Glu Val Asp Leu Val Lys 
    290                 295                 300                 


Gly Gly His Trp Trp Lys Ala Leu Ile Pro Ser Ser Gln Asn Glu Val 
305                 310                 315                 320 


Glu Leu Gly Glu Leu Leu Leu Ser Leu Asn Tyr Leu Pro Ser Ala Gly 
                325                 330                 335     


Arg Leu Asn Val Asp Val Ile Arg Ala Lys Gln Leu Leu Gln Thr Asp 
            340                 345                 350         


Val Ser Gln Gly Ser Asp Pro Phe Val Lys Ile Gln Leu Val His Gly 
        355                 360                 365             


Leu Lys Leu Val Lys Thr Lys Lys Thr Ser Phe Leu Arg Gly Thr Ile 
    370                 375                 380                 


Asp Pro Phe Tyr Asn Glu Ser Phe Ser Phe Lys Val Pro Gln Glu Glu 
385                 390                 395                 400 


Leu Glu Asn Ala Ser Leu Val Phe Thr Val Phe Gly His Asn Met Lys 
                405                 410                 415     


Ser Ser Asn Asp Phe Ile Gly Arg Ile Val Ile Gly Gln Tyr Ser Ser 
            420                 425                 430         


Gly Pro Ser Glu Thr Asn His Trp Arg Arg Met Leu Asn Thr His Arg 
        435                 440                 445             


Thr Ala Val Glu Gln Trp His Ser Leu Arg Ser Arg Ala Glu Cys Asp 
    450                 455                 460                 


Arg Val Ser Pro Ala Ser Leu Glu Val Thr 
465                 470                 


<210>  990
<211>  1180
<212>  DNA
<213>  Homo Sapiens

<400>  990
ggaggggcgg ggcggacgca gagccgcgtt tagtctatcg ctgcggttgc gagcgctgta       60

gggagcctgt gctgtgccgc gcagttaggc agcagcagcc gcggagcagt agccgccgtg      120

ggagggagcc atgaagcatt acgaggtgga gattctggac gcaaagacaa gggagaagct      180

gtgtttcttg gacaaggtgg agccccacgc caccattgcg gagatcaaga acctcttcac      240

taagacccat ccgcagtggt accccgcccg ccagtccctc cgcctggacc ccaagggcaa      300

gtccctgaag gatgaggatg ttctgcagaa gctgcccgtg ggcaccacgg ccacactgta      360

cttccgggac ctgggggccc agatcagctg ggtgacggtc ttcctaacag agtacgcggg      420

gccccttttc atctacctgc tcttctactt ccgagtgccc ttcatctatg gccacaaata      480

tgactttacg tccagtcggc atacagtggt gcacctcgcc tgcatctgtc actcattcca      540

ctacatcaag cgcctgctgg agacgctctt cgtgcaccgc ttctcccatg gcactatgcc      600

tttgcgcaac atcttcaaga actgcaccta ctactggggc ttcgccgcgt ggatggccta      660

ttacatcaat caccctctct acactccccc tacctacgga gctcagcagg tgaaactggc      720

gctcgccatc tttgtgatct gccagctcgg caacttctcc atccacatgg ccctgcggga      780

cctgcggccc gctgggtcca agacgcggaa gatcccatac cccaccaaga accccttcac      840

gtggctcttc ctgctggtgt cctgccccaa ctacacctac gaggtggggt cctggatcgg      900

tttcgccatc atgacgcagt gtctcccagt ggccctgttc tccctggtgg gcttcaccca      960

gatgaccatc tgggccaagg gcaagcaccg cagctacctg aaggagttcc gggactaccc     1020

gcccctgcgc atgcccatca tccccttcct gctctgagcg ctcacccctg ctgaggctca     1080

gcccctcaac ccggtggcat tctgggggag gagtggggcc cacagctctc cagcacccgg     1140

aataaagccc gcctgcccca gtcggaaaaa aaaaaaaaaa                           1180


<210>  991
<211>  308
<212>  PRT
<213>  Homo Sapiens

<400>  991

Met Lys His Tyr Glu Val Glu Ile Leu Asp Ala Lys Thr Arg Glu Lys 
1               5                   10                  15      


Leu Cys Phe Leu Asp Lys Val Glu Pro His Ala Thr Ile Ala Glu Ile 
            20                  25                  30          


Lys Asn Leu Phe Thr Lys Thr His Pro Gln Trp Tyr Pro Ala Arg Gln 
        35                  40                  45              


Ser Leu Arg Leu Asp Pro Lys Gly Lys Ser Leu Lys Asp Glu Asp Val 
    50                  55                  60                  


Leu Gln Lys Leu Pro Val Gly Thr Thr Ala Thr Leu Tyr Phe Arg Asp 
65                  70                  75                  80  


Leu Gly Ala Gln Ile Ser Trp Val Thr Val Phe Leu Thr Glu Tyr Ala 
                85                  90                  95      


Gly Pro Leu Phe Ile Tyr Leu Leu Phe Tyr Phe Arg Val Pro Phe Ile 
            100                 105                 110         


Tyr Gly His Lys Tyr Asp Phe Thr Ser Ser Arg His Thr Val Val His 
        115                 120                 125             


Leu Ala Cys Ile Cys His Ser Phe His Tyr Ile Lys Arg Leu Leu Glu 
    130                 135                 140                 


Thr Leu Phe Val His Arg Phe Ser His Gly Thr Met Pro Leu Arg Asn 
145                 150                 155                 160 


Ile Phe Lys Asn Cys Thr Tyr Tyr Trp Gly Phe Ala Ala Trp Met Ala 
                165                 170                 175     


Tyr Tyr Ile Asn His Pro Leu Tyr Thr Pro Pro Thr Tyr Gly Ala Gln 
            180                 185                 190         


Gln Val Lys Leu Ala Leu Ala Ile Phe Val Ile Cys Gln Leu Gly Asn 
        195                 200                 205             


Phe Ser Ile His Met Ala Leu Arg Asp Leu Arg Pro Ala Gly Ser Lys 
    210                 215                 220                 


Thr Arg Lys Ile Pro Tyr Pro Thr Lys Asn Pro Phe Thr Trp Leu Phe 
225                 230                 235                 240 


Leu Leu Val Ser Cys Pro Asn Tyr Thr Tyr Glu Val Gly Ser Trp Ile 
                245                 250                 255     


Gly Phe Ala Ile Met Thr Gln Cys Leu Pro Val Ala Leu Phe Ser Leu 
            260                 265                 270         


Val Gly Phe Thr Gln Met Thr Ile Trp Ala Lys Gly Lys His Arg Ser 
        275                 280                 285             


Tyr Leu Lys Glu Phe Arg Asp Tyr Pro Pro Leu Arg Met Pro Ile Ile 
    290                 295                 300                 


Pro Phe Leu Leu 
305             


<210>  992
<211>  2531
<212>  DNA
<213>  Homo Sapiens

<400>  992
gtgcaacctt cctccctttc ttaaatgctt ggggtgagag agaagagagg ctagggtggg       60

gcatggagga cacagagaga gagagtgctg tgtattcctt ccccgctact gtcctgtcct      120

cagctaactt gctctgggac agcttcccca gggctacaga tactgcactc agctgactgt      180

cctttcttct gggcccctgg tcccagagca gagctgacaa aggagattcc tgagagagca      240

ccttcttatc acagaaagtg ctgagccaag agctcctagc tgcccctttt gcagatgtga      300

agggccagtg aaccttggac ccagatggtt gcttaatact cctttccccc tccctcactc      360

cttcctttgc gggctgcctc acctcctcca cccttcttgc ttaaatccat aggcatttgt      420

ctggccttcc cttttactgc tggctgggaa ggaggagcat cagaccacag atcctggaag      480

gcacttctct ccctgactgc tgctcacact gccgtgagaa cctgcttata tccaggacca      540

aggaggcaat gccaggaagc tggtgaaggg tttcctctcc tccaccatgg ttgacagcac      600

tgagtatgaa gtggcctccc agcctgaggt ggaaacctcc cctttgggtg atggggccag      660

cccagggccg gagcaggtga agctgaagaa ggagatctca ctgcttaacg gcgtgtgcct      720

gattgtgggg aacatgatcg gctcgggcat ctttgtttcc cccaagggtg tgctcatata      780

cagtgcctcc tttggtctct ctctggtcat ctgggctgtc gggggcctct tctccgtctt      840

tggggccctt tgttatgcgg aactgggcac caccattaag aaatctgggg ccagctatgc      900

ctatatcctg gaggcctttg gaggattcct tgctttcatc agactctgga cctccctgct      960

catcattgag cccaccagcc aggccatcat tgccatcacc tttgccaact acatggtaca     1020

gcctctcttc ccgagctgct tcgcccctta tgctgccagc cgcctgctgg ctgctgcctg     1080

catttgtctc ttaaccttca ttaactgtgc ctatgtcaaa tggggaaccc tggtacaaga     1140

tattttcacc tatgctaaag tattggcact gatcgcggtc atcgttgcag gcattgttag     1200

acttggccag ggagcctcta ctcattttga gaattccttt gagggttcat catttgcagt     1260

gggtgacatt gccctggcac tgtactcagc tctgttctcc tactcaggct gggacaccct     1320

caactatgtc actgaagaga tcaagaatcc tgagaggaac ctgcccctct ccattggcat     1380

ctccatgccc attgtcacca tcatctatat cttgaccaat gtggcctatt atactgtgct     1440

agacatgaga gacatcttgg ccagtgatgc tgttgctgtg acttttgcag atcagatatt     1500

tggaatattt aactggataa ttccactgtc agttgcatta tcctgttttg gtggcctcaa     1560

tgcctccatt gtggctgctt ctaggctttt ctttgtgggc tcaagagaag gccatctccc     1620

tgatgccatc tgcatgatcc atgttgagcg gttcacacca gtgccttctc tgctcttcaa     1680

tggtatcatg gcattgatct acttgtgcgt ggaagacatc ttccagctca ttaactacta     1740

cagcttcagc tactggttct ttgtggggct ttctattgtg ggtcagcttt atctgcgctg     1800

gaaggagcct gatcgacctc gtcccctcaa gctcagcgtt ttcttcccga ttgtcttctg     1860

cctctgcacc atcttcctgg tggctgttcc actttacagt gatactatca actccctcat     1920

cggcattgcc attgccctct caggcctgcc cttttacttc ctcatcatca gagtgccaga     1980

acataagcga ccgctttacc tccgaaggat cgtggggtct gccacaaggt acctccaggt     2040

cctgtgtatg tcagttgctg cagaaatgga tttggaagat ggaggagaga tgcccaagca     2100

acgggatccc aaatctaact aaacaccatc tggaatcctg atgtggaaag caggggtttc     2160

tggtctactg gctagagcta aggaagttga aaaggaaagc tcacttcttt ggaggcacct     2220

gtccagaagc ctggcctagg cagcttcaac ctttgaactt actttttgaa atgaaaagta     2280

atttatttgt tttgctacat actgttccag acttttaaag gggacaatga aggtgactgt     2340

ggggaggagc atgtcaggtt tgggcttggt tgttttagaa gcacctgggt gtgcctacct     2400

actcctcttt tcttttaaaa gggcccacaa tgctccaatt tcctgtctcc tttagagaga     2460

catgaaacta tcacaggtgc tggatgacaa taaaagttta tgttcctaaa aaaaaaaaaa     2520

aaaaaaaaaa a                                                          2531


<210>  993
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  993

Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210>  994
<211>  464
<212>  DNA
<213>  Homo Sapiens

<400>  994
ctccccagcc tgataaaggt cctgcgggca ggacaggacc tcccaaccaa gccctccagc       60

aaggattcag agtgcccctc cggcctcgcc atgaggctct tcctgtcgct cccggtcctg      120

gtggtggttc tgtcgatcgt cttggaaggc ccagccccag cccaggggac cccagacgtc      180

tccagtgcct tggataagct gaaggagttt ggaaacacac tggaggacaa ggctcgggaa      240

ctcatcagcc gcatcaaaca gagtgaactt tctgccaaga tgcgggagtg gttttcagag      300

acatttcaga aagtgaagga gaaactcaag attgactcat gaggacctga agggtgacat      360

cccaggaggg gcctctgaaa tttcccacac cccagcgcct gtgctgagga ctccctccat      420

gtggccccag gtgccaccaa taaaaatcct acagaaaatt caaa                       464


<210>  995
<211>  83
<212>  PRT
<213>  Homo Sapiens

<400>  995

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  996
<211>  2354
<212>  DNA
<213>  Homo Sapiens

<400>  996
gtgacacgag ggagcgcgaa gcggagggcg cctcgcggca ggagcgggat ttccggggtc       60

acgggaaccg gcaggggaac gggataaagt tcccggagaa aggaaaggag agcgtgggat      120

agtaaaagag aagacgcgga gaagaggaga ggacctacaa gaacggagga caggggcgca      180

cgatggtccc ggggggagcg gaaacaaagg cacgcaaaac ggaaaagcgt gtgtagggga      240

gcggaaaagg aagtcaccac cgtggcctgc gacgaaatgg cgaaaagtct tttgaagaca      300

gcctctctgt ctggaaggac aaaattgcta catcaaacag gattgtcact ttatagtaca      360

tcccatggat tttatgagga agaagtgaaa aaaacacttc agcagtttcc tggtggatcc      420

attgaccttc agaaggaaga caatggcatt ggcattctta ctctgaacaa tccaagtaga      480

atgaatgcct tttcaggtgt tatgatgcta caacttctgg aaaaagtaat tgaattggaa      540

aattggacag aggggaaagg cctcattgtc cgtggggcaa aaaatacttt ctcttcagga      600

tctgatctga atgctgtgaa atcactagga actccagagg atggaatggc cgtatgcatg      660

ttcatgcaaa acaccttaac aagatttatg agacttcctt taataagtgt tgcgctggtt      720

caaggttggg cattgggtgg aggagcagaa tttactacag catgtgattt caggttaatg      780

actccagaga gtaagatcag attcgtccac aaagagatgg gcataatacc aagctggggt      840

ggcaccaccc ggctagttga aataatcgga agtagacaag ctctcaaagt gttgagtggg      900

gcccttaaac tggattcaaa aaatgctcta aacataggaa tggttgaaga ggtcttgcag      960

tcttcagatg aaactaaatc tctagaagag gcacaagaat ggctaaagca attcatccaa     1020

gggccaccgg aagtaattag agctttgaaa aaatctgttt gttcaggcag agagctatat     1080

ttggaggaag cattacagaa cgaaagagat cttttaggaa cagtttgggg tgggcctgca     1140

aatttagagg ctattgctaa gaaaggaaaa tttaataaat aattggtttt tcgtgtggat     1200

gtactccaag taaagctcca gtgactaata tgtataaatg ttaaatgata ttaaatatga     1260

acatcagaat tactttgaag gctactatta atatgcagac ttacttttaa tcatttgaat     1320

atctgaactc atttacctca tttcttgcca attactcact tgggtattta ctgcgtaatc     1380

tggaacattt agctaaaata tacacttttg gcttaaaaat tattgctgtc aattccaata     1440

ataattctta gcttataacc aaagagcagt gtttaaaagg agagcttcta tacaaaacct     1500

attcctggcg ttacttttca tacaattttt gttctgtttt acctggaaat aatttaccaa     1560

aataactgag tgttgctgct aaagaacaaa agtggggagg tatcagggaa caagaaaaca     1620

agaaagggta tgatcaatca ttttcttctg ctccaaacag ctggagtaaa attcatggga     1680

aatggccctt catttaaaaa aagatgtacc tcactaccca ctacaaattt ggaactttgt     1740

tcttttcaat aattagtttt ctattgtaaa ttacctacta aacagtggta gccatgacat     1800

ggaaagtcaa ctgattctac aattggacat tcatttgtgt gccctggaat ttccaactag     1860

taataaacaa ctactgttga tgtagtttta aaccacttga agggactcat gaagcatcct     1920

gcaacataaa tttgcatttt tacatcagat ttcttttttt tcctgaaaaa caactaacct     1980

tctaacaact atctttcaaa agtaaatgta ataaaaatgc acaacataaa atgtttatga     2040

tcccagcaat acacttttta aaaaatgtga aagtcaaaga attaagttct agttctgact     2100

catcacaaga ggtcaaaagt atttgctact gtaacattca attcacattt gagaatcatg     2160

gtaaaaataa cttgcatttg ccttaccatc atgatcctac tgttgagtta ggaaaatatg     2220

gttagacaga ctcacattac tttttttcag aggtaaactc tagattactg tgtcaaccca     2280

atactatttg gccatagatg taaaaactac caaataaaag tggattttgt ggtctacaaa     2340

aaaaaaaaaa aaaa                                                       2354


<210>  997
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  997

Met Ala Lys Ser Leu Leu Lys Thr Ala Ser Leu Ser Gly Arg Thr Lys 
1               5                   10                  15      


Leu Leu His Gln Thr Gly Leu Ser Leu Tyr Ser Thr Ser His Gly Phe 
            20                  25                  30          


Tyr Glu Glu Glu Val Lys Lys Thr Leu Gln Gln Phe Pro Gly Gly Ser 
        35                  40                  45              


Ile Asp Leu Gln Lys Glu Asp Asn Gly Ile Gly Ile Leu Thr Leu Asn 
    50                  55                  60                  


Asn Pro Ser Arg Met Asn Ala Phe Ser Gly Val Met Met Leu Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr Glu Gly Lys Gly Leu 
                85                  90                  95      


Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser Gly Ser Asp Leu Asn 
            100                 105                 110         


Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly Met Ala Val Cys Met 
        115                 120                 125             


Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg Leu Pro Leu Ile Ser 
    130                 135                 140                 


Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly Gly Ala Glu Phe Thr 
145                 150                 155                 160 


Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu Ser Lys Ile Arg Phe 
                165                 170                 175     


Val His Lys Glu Met Gly Ile Ile Pro Ser Trp Gly Gly Thr Thr Arg 
            180                 185                 190         


Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu Lys Val Leu Ser Gly 
        195                 200                 205             


Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn Ile Gly Met Val Glu 
    210                 215                 220                 


Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser Leu Glu Glu Ala Gln 
225                 230                 235                 240 


Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro Glu Val Ile Arg Ala 
                245                 250                 255     


Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu Tyr Leu Glu Glu Ala 
            260                 265                 270         


Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val Trp Gly Gly Pro Ala 
        275                 280                 285             


Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe Asn Lys 
    290                 295                 300     


<210>  998
<211>  420
<212>  DNA
<213>  Homo Sapiens

<400>  998
atggcggcgg gcagctcggg cgccagcatg ggctggcggg gctcccctgg acggccctca       60

ggtcgctcac agcattgtcc caggacttcc tcggcctgtg ccaggtgggc aaggtacagg      120

ggtagcttcc aaggcttcta tcccaactct acctatttct acctattttc tcttgagtta      180

ttttgccttt atctcagttt tatttgcaaa aatagtatac gcaaaataca tcgagtgaat      240

gcacatcagg catatagaag atctggcaga aacatgtttt ctcctgctca tttccagtca      300

gtatttgaac acagaggctt ccacggtttt gattctttcc acaaaaggtt agttttgtct      360

gttttcacca tttatgtaag tgaaactata aattatataa tttttatgtt cactcactaa      420


<210>  999
<211>  5341
<212>  DNA
<213>  Homo Sapiens

<400>  999
agctagagcc ggttttgttc gccagcagat ggcctgattc gacctctcca aaaatagaca       60

ttttaactct ctgaactcct gtttaaggaa ggatgtaatt cgctttgctc tctcctcatt      120

ttcaaggttc aaagggaagc tgcgaggatt ccaaggtccc accgccctca cagccaatga      180

ggggcctggg agggaggagc ttggtgcagc ttgagcttct gagagaatca ttcccggtag      240

atgcagcgga gtctgagctc tgctgcatct gtcacagcag aacaaaatta aaaacacaac      300

agtggaagag aaacgctgca gactatggga cgctgtagga ctttctaaaa catttgctgg      360

ggatttctgt gaagcatgat cttttaaaac gaattctttt ggaagccggt ttgggtaact      420

gggaaaatga cacatatgct aaatgcagca gctgatcgag tgaaatggac cagatcgagt      480

gctgctaaga gggctgcctg cctggtggct gcggcatatg ctctgaaaac cctctatccc      540

atcattggca agcgtttaaa gcaatctggc cacgggaaga aaaaagcagc agcttaccct      600

gctgcagaga acacagaaat actgcattgc accgagacca tttgtgaaaa accttcgcct      660

ggagtgaatg cagatttctt caaacagcta ctagaacttc ggaaaatttt gtttccaaaa      720

cttgtgacca ctgaaacagg gtggctctgc ctgcactcag tggctctaat ctcaagaacc      780

tttctttcta tctatgtggc tggtctggat ggaaaaatcg tgaaaagcat tgtggaaaag      840

aagcctcgga ctttcatcat caaattaatc aagtggctta tgattgccat ccctgctacc      900

ttcgtcaaca gtgcaataag gtacctggaa tgcaaattgg ctttggcctt cagaactcgc      960

ctagtagacc acgcctatga aacctatttt acaaatcaga cttattataa agtgatcaat     1020

atggatggga ggctggcaaa ccctgaccaa tctcttacgg aggatattat gatgttctcc     1080

caatctgtgg ctcacttgta ttccaatctg accaaaccta ttttagatgt aatgctgacc     1140

tcctatacac tcattcaaac tgctacatcc agaggagcaa gcccaattgg gcccacccta     1200

ctagcaggac ttgtggtgta tgccactgct aaagtgttaa aagcctgttc tcccaaattt     1260

ggcaaactgg tggcagagga agcacataga aaaggctatt tgcggtatgt gcactcgaga     1320

attatagcca atgtagaaga aattgccttt tacagaggac ataaggtaga aatgaaacaa     1380

cttcagaaaa gttacaaagc tttagcagat cagatgaacc tcattttatc caaacgtttg     1440

tggtacatca tgatagaaca gttcctgatg aagtatgttt ggagcagcag tggactaatt     1500

atggtggcta tacctattat cactgcaact ggctttgcag atggtgagga tggccaaaag     1560

caagttatgg ttagtgaacg gacagaagcc tttaccactg ctcgaaattt actggcctct     1620

ggagctgatg ctattgaaag gattatgtct tcatacaaag aggtcactga attagcaggc     1680

tacactgctc gagtgtacaa tatgttttgg gtctttgatg aagtaaaaag aggcatttat     1740

aagagaactg ctgtcattca agaatctgaa agccatagca agaatggagc taaggtagaa     1800

ttacctctca gtgacacatt ggcaattaaa ggaaaagtta ttgatgtgga tcacggaatt     1860

atttgtgaaa atgttcccat aattacacca gcaggagaag tggtggcttc caggctaaac     1920

ttcaaagtag aagaaggaat gcatcttttg ataactggtc ccaatggttg tgggaaaagt     1980

tctctcttca gaattctaag tgggctctgg cctgtgtatg aaggagtcct ctataaacca     2040

cctcctcaac atatgtttta tattccacaa aggccatata tgtctcttgg aagtcttcgg     2100

gatcaagtca tttaccctga ttcagtggat gatatgcatg ataaaggtta tacagaccaa     2160

gatctggaac gtatcctaca caatgtccat ctctatcaca tagttcaaag agaaggagga     2220

tgggatgctg ttatggactg gaaagatgtc ctgtcaggag gggaaaagca aagaatgggc     2280

atggctcgta tgttttatca taaaccaaaa tatgccttgc tggatgaatg taccagtgct     2340

gtcagcattg atgtcgaagg aaagatattt caggctgcaa aaggggctgg aatttcctta     2400

ctgtctataa cacacagacc ttctctttgg aaataccaca cacatttatt acagtttgat     2460

ggtgaaggag gttggcgctt tgaacaattg gatactgcta tccgtttgac attgagtgaa     2520

gaaaaacaaa agctagaatc tcagctagct ggaattccca aaatgcagca gagactcaat     2580

gaactatgta aaattttggg agaagactca gtgctgaaaa caattaaaaa tgaagatgag     2640

acatcttaat ttgttttgac atattttaaa agttaattat tagataaagg ctcaaagaca     2700

ttctgttata ctgcatgaag tatgttaagc taagcacaga gaaaaaaagg cagcaagaca     2760

tgttttataa gattttagca ttaaggaagt atatgatctg acttttcaga agaaaataaa     2820

caaatgcatt atgtaaggtc agtcattatg acttatacta attcctagtg aaggcctaat     2880

gcacttgtaa aacaggattt tctaggtgaa ttcatgatga ataccagatt tactatgtat     2940

atgtggtgtg tctgaagttc ttaacaaaca tgggcaatat tctggaaatg aaacaagtta     3000

aactgagcag catttgggtt gataccaagt gcataagatt caaactttga gtgacattta     3060

gtccatttat ggttgatatt aggtttaata gctagaattc aaattgatta ttgctagtgg     3120

ccaactaaac ctgtacaaaa tagctgacag ttttataaat aatttcaata taaaaattgt     3180

tttaatggca tttgttgaaa gaaaaaagca tggctaaaat gtataaaatg ccatattttt     3240

aaattttgga ctttaagcat cttaatgagg gcatataaca aattaatttt agtacaaatc     3300

ttaaatattt ttaataaatc ctttcatttt aaaaagagaa ttgccaatac agaaaaggag     3360

tatccaaaca atgtctcaac ctgataattt ccttagcaga attacctatt gcaacttctg     3420

ttcagaaata cacagcttgt ttttttgccc aaggatgagt ctacatttta agaactgcaa     3480

tggtataaag gaacttaagg attctgagaa tcatagtaat aacatacatt ggaatagtac     3540

tttataattt acaatcccca tttacatcat ttcaccttaa tgttgatgac aatgttttga     3600

aacaaatact atttttccta ctttgctttt gagaaaattg acactcagac ttgccctaat     3660

catgcacttt acttaaggaa agatcgagaa atcaaatgaa gttctcctga ctctctggtt     3720

tagtgctctt ttgttattat cctttaaatc aaactgggct ataatagcaa taaaagttag     3780

acgaagtgta gaaaataaaa taaatttcat aatgttagtc ttattgttat ttggttattg     3840

tttacaagaa atgaaaatta agtacaaagt gcaaagatca ttgttctgcg gcttaaaatg     3900

aaatgagaaa gttagtaaat cattcagcaa ctatgcagtc ttactcaata ttaatgtacc     3960

tctaaggcat tagcaatgag aagggcaaat aattatggtt ttggtaaagt taatatttat     4020

tgaacataat gagaaataat ctatatggac tagtcatatg aaatagattt tattctattt     4080

gtgtgcactg gagctggaaa gccaagactg aaactttatc tcttgctgcc tgtgatacca     4140

cattgacata ccagaagaat attggaatga tcagttgtta gtggcctagg attttatttg     4200

cctgttgaga cacagccata atagatgtta agtctgtgat tcttagactt ttcaggtgat     4260

agagtacctg gaagtcattc ataatgatcg ttatagaaca tcataacatt tctacatttt     4320

caattctgcc atgatagcta gtgtattttt aattttcaat aaatgtaacc aacttacatg     4380

aaggaatgca atataaaatt ataatcagta catttgtcca acgttttcat tagtattatc     4440

acctacttat tcatcagtta ctaatatttc ctgttagaaa agtgaggcag gaattaaaga     4500

ttttttttta agaagcatgg aaccaaaact taaacttgct aaaaattatt cattaatctt     4560

ttctacataa gtgattatcc agtttatact gctacaaggg caaaagtctg aggcaagtgt     4620

tttaagttaa cttttaaagg tacaagaaga aaatgaaaaa tcctcatgtg aaagatgtgt     4680

ataattttca tgccttaatt ttcataatat aaaaataaaa cataatttta aaacaacctg     4740

ataattttgt tttgaaacat tgaaaagaat gccaaaacaa atattagatt tgtaattagt     4800

cagtatttaa tatattttac ccatgagcta aagcaaaaaa gactcattat ttatgatgca     4860

caggattcaa agatgcctaa aattctgtat taaaaactat gtacactgta atttaaatgt     4920

taaagttcta atatgcacat gttttccatg agctttttgt gcctatttgt tttctgaatt     4980

tatttttcag gaccaacatc cttaacttgg aagggaaaac atctctgatt tgaacttgta     5040

tttatgtacc attcaattgt ttccaaatgg tccaatgggt ataccatatt ttactactct     5100

tatattttac ggaaaacatg aaaaagactg agaaactagc catttttgaa tacagcaagg     5160

gatagatgag gaaaggaaaa aagaaagaat atttcaagtt tcaaactact tttaccatgt     5220

tatatctatt tgcccaaacg tttgacatat ttttggtcaa acaaaaagct ataagtttat     5280

ggagcttgag tttaaaatgt gcattcttta ggttaactct taaacttgaa aaataagttg     5340

g                                                                     5341


<210>  1000
<211>  740
<212>  PRT
<213>  Homo Sapiens

<400>  1000

Met Thr His Met Leu Asn Ala Ala Ala Asp Arg Val Lys Trp Thr Arg 
1               5                   10                  15      


Ser Ser Ala Ala Lys Arg Ala Ala Cys Leu Val Ala Ala Ala Tyr Ala 
            20                  25                  30          


Leu Lys Thr Leu Tyr Pro Ile Ile Gly Lys Arg Leu Lys Gln Ser Gly 
        35                  40                  45              


His Gly Lys Lys Lys Ala Ala Ala Tyr Pro Ala Ala Glu Asn Thr Glu 
    50                  55                  60                  


Ile Leu His Cys Thr Glu Thr Ile Cys Glu Lys Pro Ser Pro Gly Val 
65                  70                  75                  80  


Asn Ala Asp Phe Phe Lys Gln Leu Leu Glu Leu Arg Lys Ile Leu Phe 
                85                  90                  95      


Pro Lys Leu Val Thr Thr Glu Thr Gly Trp Leu Cys Leu His Ser Val 
            100                 105                 110         


Ala Leu Ile Ser Arg Thr Phe Leu Ser Ile Tyr Val Ala Gly Leu Asp 
        115                 120                 125             


Gly Lys Ile Val Lys Ser Ile Val Glu Lys Lys Pro Arg Thr Phe Ile 
    130                 135                 140                 


Ile Lys Leu Ile Lys Trp Leu Met Ile Ala Ile Pro Ala Thr Phe Val 
145                 150                 155                 160 


Asn Ser Ala Ile Arg Tyr Leu Glu Cys Lys Leu Ala Leu Ala Phe Arg 
                165                 170                 175     


Thr Arg Leu Val Asp His Ala Tyr Glu Thr Tyr Phe Thr Asn Gln Thr 
            180                 185                 190         


Tyr Tyr Lys Val Ile Asn Met Asp Gly Arg Leu Ala Asn Pro Asp Gln 
        195                 200                 205             


Ser Leu Thr Glu Asp Ile Met Met Phe Ser Gln Ser Val Ala His Leu 
    210                 215                 220                 


Tyr Ser Asn Leu Thr Lys Pro Ile Leu Asp Val Met Leu Thr Ser Tyr 
225                 230                 235                 240 


Thr Leu Ile Gln Thr Ala Thr Ser Arg Gly Ala Ser Pro Ile Gly Pro 
                245                 250                 255     


Thr Leu Leu Ala Gly Leu Val Val Tyr Ala Thr Ala Lys Val Leu Lys 
            260                 265                 270         


Ala Cys Ser Pro Lys Phe Gly Lys Leu Val Ala Glu Glu Ala His Arg 
        275                 280                 285             


Lys Gly Tyr Leu Arg Tyr Val His Ser Arg Ile Ile Ala Asn Val Glu 
    290                 295                 300                 


Glu Ile Ala Phe Tyr Arg Gly His Lys Val Glu Met Lys Gln Leu Gln 
305                 310                 315                 320 


Lys Ser Tyr Lys Ala Leu Ala Asp Gln Met Asn Leu Ile Leu Ser Lys 
                325                 330                 335     


Arg Leu Trp Tyr Ile Met Ile Glu Gln Phe Leu Met Lys Tyr Val Trp 
            340                 345                 350         


Ser Ser Ser Gly Leu Ile Met Val Ala Ile Pro Ile Ile Thr Ala Thr 
        355                 360                 365             


Gly Phe Ala Asp Gly Glu Asp Gly Gln Lys Gln Val Met Val Ser Glu 
    370                 375                 380                 


Arg Thr Glu Ala Phe Thr Thr Ala Arg Asn Leu Leu Ala Ser Gly Ala 
385                 390                 395                 400 


Asp Ala Ile Glu Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu 
                405                 410                 415     


Ala Gly Tyr Thr Ala Arg Val Tyr Asn Met Phe Trp Val Phe Asp Glu 
            420                 425                 430         


Val Lys Arg Gly Ile Tyr Lys Arg Thr Ala Val Ile Gln Glu Ser Glu 
        435                 440                 445             


Ser His Ser Lys Asn Gly Ala Lys Val Glu Leu Pro Leu Ser Asp Thr 
    450                 455                 460                 


Leu Ala Ile Lys Gly Lys Val Ile Asp Val Asp His Gly Ile Ile Cys 
465                 470                 475                 480 


Glu Asn Val Pro Ile Ile Thr Pro Ala Gly Glu Val Val Ala Ser Arg 
                485                 490                 495     


Leu Asn Phe Lys Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro 
            500                 505                 510         


Asn Gly Cys Gly Lys Ser Ser Leu Phe Arg Ile Leu Ser Gly Leu Trp 
        515                 520                 525             


Pro Val Tyr Glu Gly Val Leu Tyr Lys Pro Pro Pro Gln His Met Phe 
    530                 535                 540                 


Tyr Ile Pro Gln Arg Pro Tyr Met Ser Leu Gly Ser Leu Arg Asp Gln 
545                 550                 555                 560 


Val Ile Tyr Pro Asp Ser Val Asp Asp Met His Asp Lys Gly Tyr Thr 
                565                 570                 575     


Asp Gln Asp Leu Glu Arg Ile Leu His Asn Val His Leu Tyr His Ile 
            580                 585                 590         


Val Gln Arg Glu Gly Gly Trp Asp Ala Val Met Asp Trp Lys Asp Val 
        595                 600                 605             


Leu Ser Gly Gly Glu Lys Gln Arg Met Gly Met Ala Arg Met Phe Tyr 
    610                 615                 620                 


His Lys Pro Lys Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser 
625                 630                 635                 640 


Ile Asp Val Glu Gly Lys Ile Phe Gln Ala Ala Lys Gly Ala Gly Ile 
                645                 650                 655     


Ser Leu Leu Ser Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr 
            660                 665                 670         


His Leu Leu Gln Phe Asp Gly Glu Gly Gly Trp Arg Phe Glu Gln Leu 
        675                 680                 685             


Asp Thr Ala Ile Arg Leu Thr Leu Ser Glu Glu Lys Gln Lys Leu Glu 
    690                 695                 700                 


Ser Gln Leu Ala Gly Ile Pro Lys Met Gln Gln Arg Leu Asn Glu Leu 
705                 710                 715                 720 


Cys Lys Ile Leu Gly Glu Asp Ser Val Leu Lys Thr Ile Lys Asn Glu 
                725                 730                 735     


Asp Glu Thr Ser 
            740 


<210>  1001
<211>  6246
<212>  DNA
<213>  Homo Sapiens

<400>  1001
gacttaaact ctggggcccg ggaggccgcc ggttttctcc ccgcttgccg gggtggtcct       60

cttccctttg tcggaccaaa gaagtaaaca ctgtgtggag agggactgac gtgtttggag      120

ggaaatggga atgtacacga taattaaaga gtaaagttgt gctcaacgct gtttacttct      180

aattatttcc tgattcacaa attaattttt gcaattcaca acttcaagaa tacttggact      240

attggattca atccatagta atctgcaaaa gaagagaagc agaattatac ctagaagtct      300

actaatggac agttagtcac ccacctacat gttgagattc ctgacattca gacaactgac      360

ttgtaactga cttataactg acttgtaata cactgctact atatcaaacc gacaatgaat      420

tggaatgaaa aaccaaagag tgctacatta ccaccactgt atcctaaaag ccagccacct      480

tttttgcacc agtctttaat aaaccaaatt accacaacat ctcagagttc tttcagctat      540

cctggaagta accaagaagc atgcatgtat cccggtaatt caaatccaat ttcacagcca      600

ctgctgaata tccaaaatta tcctcaacaa atttctgttt ctgatatgca taatgggaca      660

gttgtggcct cacacacttc agtagaaaga ataacatatg caaatgttaa tggacccaaa      720

caactaactc acaatttgca gatgtcttca ggagttaccc aaaacgtatg gttgaactca      780

ccaatgagga atcctgtgca ttctcatata ggggcaactg tatctcatca aactgatttt      840

ggagctaacg tacccaatat gccggcacta cagagtcaac tgataacatc agatacctat      900

tctatgcaaa tgcagatgat cccttctaat tctacacgac ttcctgtagc ttaccaagga      960

aatcagggac ttaaccagtc tttttcagag caacaggttg attggacaca acagtgtata     1020

tctaagggac tgacttaccc agattacaga ccacctccaa agctataccg ttactcacca     1080

caaagctttt taccagattc taccattcaa aaacaaaact ttataccaca tacatcattg     1140

caagttaaaa atagtcagct tctaaattct gtattaactt taccatcaag gcagacctca     1200

gctgtaccat cacagcagta tgccacgcaa actgacaaaa gacctcctcc tcctccttac     1260

aactgtagat atggaagcca gcctttgcaa agtactcagc atattactaa acacttgtct     1320

atggaagttc ctcagagtcg agaaatgctg tcatctgaaa taaggaccag ctttcaacag     1380

cagtggcaaa accctaatga aaatgtcagc acaattggaa atttcactaa cttgaaagta     1440

aataccaaca gcaaacagcc ttttaacagt cccattagat cttctgtgga tggtgttcag     1500

actcttgctc aaactaatga agagaaaata atggattctt gcaatccaac ttcaaatcaa     1560

gtactggaca caagtgttgc aaaagaaaag ctagtaaggg atattaaaac attagtagag     1620

ataaaacaga agttttcaga acttgcaagg aaaattaaaa tcaataaaga tcttttgatg     1680

gcagcaggtt gtattaaaat gactaatact tcttatagtg aaccagctca gaattctaaa     1740

ttgtctctaa aacaaactgc caaaatccag tctggacccc agataactcc agtaatgcca     1800

gagaatgcag agagacaaac accaacagta gtggaatctg cagaaacaaa taagactcaa     1860

tgtatgttga attctgacat tcaggaagtc aattgcagaa ggtttaacca agttgattct     1920

gttttaccaa atcctgtcta ttctgaaaag cggccaatgc cagacccatc tcatgatgtg     1980

aaagttctca cttcaaagac atcagctgtt gagatgaccc aggcagtatt gaatactcag     2040

ctttcatcag aaaatgttac caaagttgag caaaattcac cagcagtttg tgaaacaatt     2100

tctgttccca agtccatgtc cactgaggaa tataaatcaa aaattcaaaa tgaaaatatg     2160

ctacttctcg ctttgctttc acaggcacgt aagactcaga agacagtatt aaaagatgct     2220

aatcaaacta ttcaggattc taaaccagac agttgtgaaa tgaatccaaa tacccaaatg     2280

actggtaacc aactgaattt gaagaacatg gaaactccaa gtacttctaa tgtaagtggc     2340

agggttttgg acaactcctt ttgcagtgga caagaatcct caacaaaagg aatgcctgct     2400

aaaagtgaca gtagctgttc catggaagtg ctagcaacct gtctttccct gtggaaaaag     2460

caaccttcag atactgcaaa agaaaaggag tgtgataaac tcagaacaaa cacaacagca     2520

gttggaattt caaagcctgc taacatccac gttaagagtc cttgttcagt tgtgggaaat     2580

tcaaattctc agaataaaat aagtaatccc tcacagcaga cagctttgtc gatggtaatg     2640

cacaattatg agtcttcagg tataaatata acaaagggaa cagaacttca gatagctgta     2700

gtgtcaccgt tagttctgtc agaggtcaaa acattgtctg tcaaaggaat aacacctgca     2760

gtgttacctg aaacagtgta tcccgttatt aaagaaggca gtgtttgtag tttacaaaat     2820

caattggcag aaaatgcaaa ggcaactgct gctttgaaag ttgatgttag tggaccagta     2880

gcaagtacag caacatcaac caagattttt ccactaactc agaaggaaaa gcagaatgag     2940

tcaactaatg gtaattcaga agtcacacct aatgtcaatc aaggaaagca taacaaatta     3000

gagtcagcta tccattctcc tatgaacgat cagcaaatct cacaggagtc aaggaatagt     3060

actgttgtga gtagtgatac attacagatt gacaatattt gttctctggt tgaaggtgat     3120

acctcttaca attcccaaat agcaaagata ttcagctctc ttcccttgaa aatggttgag     3180

ccacagaaac cttctctacc caatcagcaa gggattggca gcagagaacc agaaaaacaa     3240

ttagataata ccactgaaaa taaagacttt ggttttcaaa aagataaacc tgtacagtgc     3300

acagatgttt cacataaaat atgtgatcag tcaaagtcag agccaccctt agagtcatct     3360

tttaacaatc ttgaaacaaa cagagttatt ctagagaaaa gtagtttgga gcatgccact     3420

gaaaaaagca cagctaacga tacgtgctcg tcagctgcta ttcaggagga tatttaccct     3480

caggaaatag atgcatccag caactatact ccccaagatc ctgcaagaaa tgaaatccac     3540

agtgataagg cacctgtctt atacctacat gaccagctgt cagaacttct aaaagagttt     3600

ccttatggca ttgaggctgt gaatacacgt gaaggttctg tgggccagca aactacatac     3660

cagacctcag aagatcaaac tgctgataaa accagttctg actccaaaga cccagcagat     3720

caaatacaaa ttacaatatt aagctcagag caaatgaaag aaatatttcc tgaacaggat     3780

gatcaaccct atgtagtaga caagttggca gaacctcaga aagaagagcc catcacagaa     3840

gtagttagcc agtgtgacct gcaggcacct gcagctggac aaagtcgtga ttctgtgata     3900

ctggactctg agaaagatga tatccactgc tgtgcattgg gctggctctc catggtttac     3960

gaaggagtac cccagtgtca gtgtaattcc atcaagaact catcttcaga ggaagagaaa     4020

caaaaagagc agtgttctcc tttggatacc aacagttgta aacaaggaga gagaacttct     4080

gatagagatg tcactgttgt tcaatttaag agccttgtaa ataatccaaa gactcctcca     4140

gatgggaaaa gtcattttcc tgaactacaa gacgacagta gaaaagatac acccaaaaca     4200

aaacataaaa gcttaccaag gacagaacaa gaattagttg ctggtcagtt ttcatctaaa     4260

tgtgataaac taaatccctt gcaaaatcac aaaagaaaaa aattgaggtt tcacgaggta     4320

acctttcact ccagtaataa aatgacagca tcttatgaac aagcttctca ggaaacccga     4380

cagaagaaac atgtaacaca gaactcacgt ccactaaaaa caaaaacagc ttttttgcca     4440

aataaagatg tgtataagaa gcatagttct ttgggacagt cattatcacc agaaaagata     4500

aaattgaaac tcaaatcagt tagcttcaaa caaaaacgaa agttagacca agggaacgta     4560

ttagatatgg aagtaaagaa aaagaaacat gataaacaag aacagaaagg aagtgtggga     4620

gctacattca aattaggtga ctctttgtca aacccaaacg aaagagccat tgttaaagaa     4680

aagatggtat caaatactaa gtctgtagac acgaaagcga gttcatctaa atttagtaga     4740

attctaactc ctaaggagta tttacaaagg cagaagcata aagaagctct gagtaataaa     4800

gcatcgaaga aaatctgtgt gaaaaacgtg ccatgtgatt ctgaacatat gagaccaagt     4860

aaacttgccg tgcaggttga aagttgtggg aaatcaaatg agaaacacag cagcggcgtg     4920

cagacctcta aagaatcatt aaatggcttg acaagccatg gtaaaaacct caaaatccac     4980

cattctcagg agtctaaaac atacaacatt ctaaggaatg ttaaagaaaa agttggtggg     5040

aagcagcctg ataaaatatg gattgataag actaaattag acaaattaac caatataagc     5100

aacgaagctc aattcagcca aatgcctccc caagtaaagg atcaaaagaa attatatctg     5160

aatagagttg ggtttaaatg cactgaacgt gaaagcattt ctctcaccaa attagaaagt     5220

tcacccagga agcttcataa agataagaga caggaaaata aacataagac ctttttaccg     5280

gtgaaaggta acacagaaaa atcaaacatg ctggagttta aattatgtcc agatatctta     5340

ctaaagaata caaactctgt ggaagaacgg aaggatgtaa agcctcatcc taggaaggag     5400

caagcccctc tgcaagtttc aggaataaaa agtacaaaag aagactggtt aaaatttgtt     5460

gctacaaaga aaaggacaca gaaagacagc caagagagag ataatgttaa ttcaagactc     5520

tcgaagagaa gcttcagtgc agatggattt gagatgctac aaaacccagt aaaagattca     5580

aaagaaatgt ttcaaaccta caaacagatg tacctggaga agagaagcag aagccttggt     5640

agcagtcctg taaaataatt acaagatgtg gttttgtaat tgccactggg aaatttcttt     5700

ccttttctgt tcaaaatatt tcgctgaaac taatgagaaa tgccatgata aagatttctc     5760

agagtttggt tcccactttc attgtatttc attgaaagtg cttaattaaa atggcttgag     5820

aactttgggt agccatgtgt aagaaatgga tggtattcac cggggaaaca aggtatttga     5880

atttctactt tattgaacca gatttaccat tattttaaaa ggaatgctta tacaaatcaa     5940

tttgaaattc tacccatctt gagggaggac cgttcctcag ttaaggactt gtttatttaa     6000

atgggactgt aaatatgttt tggtttctaa gctatattag caaaatttat ttttcaaaaa     6060

tgcccactgt gatgtgaatg tcaaaatata ttcttaagtg ttttataact aattgtaaac     6120

tttttttcag aagtcttatt ttatacttgt gaaactgaac acaattttgg gacaacgttt     6180

aaacattact tttcatactt gaaataaaca tttatttttt aaaaaactaa aaaaaaaaaa     6240

aaaaaa                                                                6246


<210>  1002
<211>  1747
<212>  PRT
<213>  Homo Sapiens

<400>  1002

Met Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr 
1               5                   10                  15      


Pro Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile 
            20                  25                  30          


Thr Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu 
        35                  40                  45              


Ala Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu 
    50                  55                  60                  


Asn Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn 
65                  70                  75                  80  


Gly Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala 
                85                  90                  95      


Asn Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser 
            100                 105                 110         


Gly Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val 
        115                 120                 125             


His Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala 
    130                 135                 140                 


Asn Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu 
                165                 170                 175     


Pro Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu 
            180                 185                 190         


Gln Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr 
        195                 200                 205             


Pro Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser 
    210                 215                 220                 


Phe Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr 
225                 230                 235                 240 


Ser Leu Gln Val Lys Asn Ser Gln Leu Leu Asn Ser Val Leu Thr Leu 
                245                 250                 255     


Pro Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln 
            260                 265                 270         


Thr Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser 
        275                 280                 285             


Gln Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu 
    290                 295                 300                 


Val Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe 
305                 310                 315                 320 


Gln Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn 
                325                 330                 335     


Phe Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser 
            340                 345                 350         


Pro Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn 
        355                 360                 365             


Glu Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu 
    370                 375                 380                 


Asp Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu 
385                 390                 395                 400 


Val Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile 
                405                 410                 415     


Asn Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr 
            420                 425                 430         


Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr 
        435                 440                 445             


Ala Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn 
    450                 455                 460                 


Ala Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys 
465                 470                 475                 480 


Thr Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg 
                485                 490                 495     


Phe Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys 
            500                 505                 510         


Arg Pro Met Pro Asp Pro Ser His Asp Val Lys Val Leu Thr Ser Lys 
        515                 520                 525             


Thr Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser 
    530                 535                 540                 


Ser Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu 
545                 550                 555                 560 


Thr Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys 
                565                 570                 575     


Ile Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg 
            580                 585                 590         


Lys Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp 
        595                 600                 605             


Ser Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly 
    610                 615                 620                 


Asn Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val 
625                 630                 635                 640 


Ser Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser 
                645                 650                 655     


Thr Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val 
            660                 665                 670         


Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala 
        675                 680                 685             


Lys Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly 
    690                 695                 700                 


Ile Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val 
705                 710                 715                 720 


Gly Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr 
                725                 730                 735     


Ala Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile 
            740                 745                 750         


Thr Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu 
        755                 760                 765             


Ser Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu 
    770                 775                 780                 


Pro Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu 
785                 790                 795                 800 


Gln Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val 
                805                 810                 815     


Asp Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe 
            820                 825                 830         


Pro Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser 
        835                 840                 845             


Glu Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser 
    850                 855                 860                 


Ala Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg 
865                 870                 875                 880 


Asn Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys 
                885                 890                 895     


Ser Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile 
            900                 905                 910         


Phe Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu 
        915                 920                 925             


Pro Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp 
    930                 935                 940                 


Asn Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val 
945                 950                 955                 960 


Gln Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu 
                965                 970                 975     


Pro Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile 
            980                 985                 990         


Leu Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn 
        995                 1000                 1005             


Asp Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln 
    1010                 1015                 1020             


Glu Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg 
    1025                 1030                 1035             


Asn Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp 
    1040                 1045                 1050             


Gln Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala 
    1055                 1060                 1065             


Val Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln 
    1070                 1075                 1080             


Thr Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys 
    1085                 1090                 1095             


Asp Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln 
    1100                 1105                 1110             


Met Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val 
    1115                 1120                 1125             


Asp Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Asp Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys 
    1160                 1165                 1170             


Ala Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys 
    1175                 1180                 1185             


Gln Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Lys Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly 
    1205                 1210                 1215             


Glu Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser 
    1220                 1225                 1230             


Leu Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe 
    1235                 1240                 1245             


Pro Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys 
    1250                 1255                 1260             


His Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln 
    1265                 1270                 1275             


Phe Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys 
    1280                 1285                 1290             


Arg Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn 
    1295                 1300                 1305             


Lys Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln 
    1310                 1315                 1320             


Lys Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr 
    1325                 1330                 1335             


Ala Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu 
    1340                 1345                 1350             


Gly Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser 
    1355                 1360                 1365             


Val Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu 
    1370                 1375                 1380             


Asp Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys 
    1385                 1390                 1395             


Gly Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn 
    1400                 1405                 1410             


Pro Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr 
    1415                 1420                 1425             


Lys Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile 
    1430                 1435                 1440             


Leu Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala 
    1445                 1450                 1455             


Leu Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro 
    1460                 1465                 1470             


Cys Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val 
    1475                 1480                 1485             


Glu Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln 
    1490                 1495                 1500             


Thr Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn 
    1505                 1510                 1515             


Leu Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu 
    1520                 1525                 1530             


Arg Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile 
    1535                 1540                 1545             


Trp Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn 
    1550                 1555                 1560             


Glu Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys 
    1565                 1570                 1575             


Lys Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu 
    1580                 1585                 1590             


Ser Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His 
    1595                 1600                 1605             


Lys Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val 
    1610                 1615                 1620             


Lys Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys 
    1625                 1630                 1635             


Pro Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys 
    1640                 1645                 1650             


Asp Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val 
    1655                 1660                 1665             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala 
    1670                 1675                 1680             


Thr Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val 
    1685                 1690                 1695             


Asn Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu 
    1700                 1705                 1710             


Met Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr 
    1715                 1720                 1725             


Tyr Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser 
    1730                 1735                 1740             


Ser Pro  Val Lys 
    1745         


<210>  1003
<211>  1872
<212>  DNA
<213>  Homo Sapiens

<400>  1003
ggcagccaga agcacctgtg ctcccaggat aagggtgagc actcaggatg actgtggaga       60

aggaggcccc tgatgcgcac ttcactgtgg acaaacagaa catctccctc tggccccgag      120

agcctcctcc caagtccggt ccatctctgg tcccggggaa aacacccaca gtccgtgctg      180

cattaatctg cctgacgctg gtcctggtcg cctccgtcct gctgcaggcc gtcctttatc      240

cccggtttat gggcaccata tcagatgtaa agaccaatgt ccagttgctg aaaggtcgtg      300

tggacaacat cagcaccctg gattctgaaa ttaaaaagaa tagtgacggc atggaggcag      360

ctggcgttca gatccagatg gtgaatgaga gcctgggtta tgtgcgttct cagttcctga      420

agttaaaaac cagtgtggag aaggccaacg cacagatcca gatcttaaca agaagttggg      480

aagaagtcag taccttaaat gcccaaatcc cagagttaaa aagtgatttg gagaaagcca      540

gtgctttaaa tacaaagatc cgggcactcc agggcagctt ggagaatatg agcaagttgc      600

tcaaacgaca aaatgatatt ctacaggtgg tttctcaagg ctggaagtac ttcaagggga      660

acttctatta cttttctctc attccaaaga cctggtatag tgccgagcag ttctgtgtgt      720

ccaggaattc acacctgacc tcggtgacct cagagagtga gcaggagttt ctgtataaaa      780

cagcgggggg actcatctac tggattggcc tgactaaagc agggatggaa ggggactggt      840

cctgggtgga tgacacgcca ttcaacaagg tccaaagtgc gaggttctgg attccaggtg      900

agcccaacaa tgctgggaac aatgaacact gtggcaatat aaaggctccc tcacttcagg      960

cctggaatga tgccccatgt gacaaaacgt ttcttttcat ttgtaagcga ccctatgtcc     1020

catcagaacc gtgacaggac aggctcccaa gctcactctt tgagctccaa cgcttgttaa     1080

acatgaggaa atgcctcttt cttccccaga ctccaggatg actttgcacg ttaatttttc     1140

ttgcttcaaa attgtcccac agtggcattc tggagtccgt ctgtcttggc tggaaattct     1200

ctgacgtctt ggaggcagct ggaatggaaa ggagaattca ggttaaagtg ggaggggtgg     1260

gtagagagga tttagaagtt ccaattgccc tgctaaggag gatcaagacc cgtaatccgg     1320

cataacaccc tggggttttc cactctttca gagaaacctc agcttcatca catcaaagtt     1380

actccagagc aaccaagcaa ttctcctgat attgtcatcc agggcttttc ttggccaaac     1440

cccctagaat ttccatgtct ctgcttagct gtgctggcag ctagcagctg gctgtgtttg     1500

cagtgcaaat agctctgttc ttggaaatcc tgctcatggt atgtccccag tggtttcttc     1560

atccacatca tctaaagcct gaacccgttc ttctctggtt caagtcagtg gctgacacgg     1620

acttgtatct ccttcagagc tcggctggca cccagcctcc cttctccttc cactccctta     1680

gtacactgga gtgccgagcc ctgccttcca cccagcgtcc atccagcccc tgtcctcacc     1740

tctccggcac ctcctcctcc ttctgcattt cctatcttcc tgtgtcttgt gcatgggaag     1800

cagccttcag tgccttcatg aattcacctt ccagcttcct cagaataaaa tgctgcctgg     1860

gtcaaggact ca                                                         1872


<210>  1004
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  1004

Met Thr Val Glu Lys Glu Ala Pro Asp Ala His Phe Thr Val Asp Lys 
1               5                   10                  15      


Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Pro Gly Lys Thr Pro Thr Val Arg Ala Ala Leu Ile Cys 
        35                  40                  45              


Leu Thr Leu Val Leu Val Ala Ser Val Leu Leu Gln Ala Val Leu Tyr 
    50                  55                  60                  


Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys 
                85                  90                  95      


Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val 
            100                 105                 110         


Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr 
        115                 120                 125             


Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp 
    130                 135                 140                 


Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly 
                165                 170                 175     


Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu 
            180                 185                 190         


Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr 
        195                 200                 205             


Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val 
    210                 215                 220                 


Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu 
225                 230                 235                 240 


Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr 
                245                 250                 255     


Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe 
            260                 265                 270         


Asn Lys Val Gln Ser Ala Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn 
        275                 280                 285             


Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln 
    290                 295                 300                 


Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys 
305                 310                 315                 320 


Arg Pro Tyr Val Pro Ser Glu Pro 
                325             


<210>  1005
<211>  1690
<212>  DNA
<213>  Homo Sapiens

<400>  1005
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa      480

tgaactgcag aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg      540

ccggaggggc aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac      600

ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa cagccagggg atttcaccac      660

tcaaaggcca gacctgcaga cgcccagatt atgagacaca ggatgaagca tttacaaccc      720

ggttcactct tctcagccac tgaagtattc ccctttatgt acaggatgct ttggttatat      780

ttagctccaa accttcacac acagactgtt gtccctgcac tctttaaggg agtgtactcc      840

cagggcttac ggccctggcc ttgggccctc tggtttgccg gtggtgcagg tagacctgtc      900

tcctggcggt tcctcgttct ccctgggagg cgggcgcact gcctctcaca gctgagttgt      960

tgagtctgtt ttgtaaagtc cccagagaaa gcgcagatgc tagcacatgc cctaatgtct     1020

gtatcactct gtgtctgagt ggcttcactc ctgctgtaaa tttggcttct gttgtcacct     1080

tcacctcctt tcaaggtaac tgtactgggc catgttgtgc ctccctggtg agagggccgg     1140

gcagaggggc agatggaaag gagcctaggc caggtgcaac cagggagctg caggggcatg     1200

ggaaggtggg cgggcagggg agggtcagcc agggcctgcg agggcagcgg gagcctccct     1260

gcctcaggcc tctgtgccgc accattgaac tgtaccatgt gctacagggg ccagaagatg     1320

aacagactga ccttgatgag ctgtgcacaa agtggcataa aaaacatgtg gttacacagt     1380

gtgaataaag tgctgcggag caagaggagg ccgttgattc acttcacgct ttcagcgaat     1440

gacaaaatca tctttgtgaa ggcctcgcag gaagacccaa cacatgggac ctataactgc     1500

ccagcggaca gtggcaggac aggaaaaacc cgtcaatgta ctaggatact gctgcgtcat     1560

tacagggcac aggccatgga tggaaaacgc tctctgctct gctttttttc tactgtttta     1620

atttatactg gcatgctaaa gccttcctat tttgcataat aaatgcttca gtgaaaatgc     1680

aaaaaaaaaa                                                            1690


<210>  1006
<211>  164
<212>  PRT
<213>  Homo Sapiens

<400>  1006

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  1007
<211>  1320
<212>  DNA
<213>  Homo Sapiens

<400>  1007
cggaagggga agggggtgga ggttgctgct atgagagaga aaaaaaaaac agccacaata       60

gagattctgc cttcaaaggt tggcttgcca cctgaagcag ccactgccca gggggtgcaa      120

agaagagaca gcagcgccca gcttggaggt gctaactcca gaggccagca tcagcaactg      180

ggcacagaaa ggagccgcct gggcagggac catggcacgg ccacatccct ggtggctgtg      240

cgttctgggg accctggtgg ggctctcagc tactccagcc cccaagagct gcccagagag      300

gcactactgg gctcagggaa agctgtgctg ccagatgtgt gagccaggaa cattcctcgt      360

gaaggactgt gaccagcata gaaaggctgc tcagtgtgat ccttgcatac cgggggtctc      420

cttctctcct gaccaccaca cccggcccca ctgtgagagc tgtcggcact gtaactctgg      480

tcttctcgtt cgcaactgca ccatcactgc caatgctgag tgtgcctgtc gcaatggctg      540

gcagtgcagg gacaaggagt gcaccgagtg tgatcctctt ccaaaccctt cgctgaccgc      600

tcggtcgtct caggccctga gcccacaccc tcagcccacc cacttacctt atgtcagtga      660

gatgctggag gccaggacag ctgggcacat gcagactctg gctgacttca ggcagctgcc      720

tgcccggact ctctctaccc actggccacc ccaaagatcc ctgtgcagct ccgattttat      780

tcgcatcctt gtgatcttct ctggaatgtt ccttgttttc accctggccg gggccctgtt      840

cctccatcaa cgaaggaaat atagatcaaa caaaggagaa agtcctgtgg agcctgcaga      900

gccttgtcgt tacagctgcc ccagggagga ggagggcagc accatcccca tccaggagga      960

ttaccgaaaa ccggagcctg cctgctcccc ctgagccagc acctgcggga gctgcactac     1020

agccctggcc tccaccccca ccccgccgac catccaaggg agagtgagac ctggcagcca     1080

caactgcagt cccatcctct tgtcagggcc ctttcctgtg tacacgtgac agagtgcctt     1140

ttcgagactg gcagggacga ggacaaatat ggatgaggtg gagagtggga agcaggagcc     1200

cagccagctg cgcctgcgct gcaggagggc gggggctctg gttgtaaaac acacttcctg     1260

ctgcgaaaga cccacatgct acaagacggg caaaataaag tgacagatga ccaccctgca     1320


<210>  1008
<211>  260
<212>  PRT
<213>  Homo Sapiens

<400>  1008

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  1009
<211>  2248
<212>  DNA
<213>  Homo Sapiens

<400>  1009
gatcatctga taatgctttg cctgcactca ggacctgtct ttgtccctcc tcttaacata       60

cttgcagcta aaactaaata ttgctgcttg gggacctcct tctagcctta aatttcagct      120

catcaccttc acctgccttg gtcatggctc tgctattctc cttgatcctt gccatttgca      180

ccagacctgg attcctagcg tctccatctg gagtgcggct ggtggggggc ctccaccgct      240

gtgaagggcg ggtggaggtg gaacagaaag gccagtgggg caccgtgtgt gatgacggct      300

gggacattaa ggacgtggct gtgttgtgcc gggagctggg ctgtggagct gccagcggaa      360

cccctagtgg tattttgtat gagccaccag cagaaaaaga gcaaaaggtc ctcatccaat      420

cagtcagttg cacaggaaca gaagatacat tggctcagtg tgagcaagaa gaagtttatg      480

attgttcaca tgatgaagat gctggggcat cgtgtgagaa cccagagagc tctttctccc      540

cagtcccaga gggtgtcagg ctggctgacg gccctgggca ttgcaaggga cgcgtggaag      600

tgaagcacca gaaccagtgg tataccgtgt gccagacagg ctggagcctc cgggccgcaa      660

aggtggtgtg ccggcagctg ggatgtggga gggctgtact gactcaaaaa cgctgcaaca      720

agcatgccta tggccgaaaa cccatctggc tgagccagat gtcatgctca ggacgagaag      780

caacccttca ggattgccct tctgggcctt gggggaagaa cacctgcaac catgatgaag      840

acacgtgggt cgaatgtgaa gatccctttg acttgagact agtaggagga gacaacctct      900

gctctgggcg actggaggtg ctgcacaagg gcgtatgggg ctctgtctgt gatgacaact      960

ggggagaaaa ggaggaccag gtggtatgca agcaactggg ctgtgggaag tccctctctc     1020

cctccttcag agaccggaaa tgctatggcc ctggggttgg ccgcatctgg ctggataatg     1080

ttcgttgctc aggggaggag cagtccctgg agcagtgcca gcacagattt tgggggtttc     1140

acgactgcac ccaccaggaa gatgtggctg tcatctgctc aggatagtat cctggtgttg     1200

cttgacctgg cccccctggc cccgcctgcc ctctgcttgt tctcctgagc cctgattatc     1260

ctcatactca ttctggggct caggcttgag ccactactcc ctcatcccct caggagtctg     1320

aacactgggc ttatgcctta ctctcaggga caagcagccc ccattgctgc ctgtagatgt     1380

gagctgttga gttccctctt gctggggaag atgagcttcc atgtatcctg tgctcaaccc     1440

tgaccctttg acactggttc tggcctttcc tgccttttct caagctgcct ggaatcctca     1500

aacctgtcac tttggtcaga tgtgcagacc attactaagg tctatgtctg caaacattac     1560

taatctaggt cctattacta atctatgtct gcaaacatta aaggaatgaa acaatgaaag     1620

gaacatttga aagaaaatgt gggtagacaa tttcttgcaa cttgggggaa agtttagaat     1680

tcttttgatt ggactacttt tttttttttt cctcaagctt caggtgacca caatagcaac     1740

acctccctat tctgttattt cttagtgtag gtagacaatt ctttcaggag cagagcagcg     1800

tcctataatc ctagaccttt tcatgacgtg taaaaaatga tgtttcatcc tctgattgcc     1860

ccaataaaaa tctttgttgt ccatccctat acaacctgcc aacatggttg acatttaatg     1920

agaggaatgt caaaaataca ttttacttta ttcaaagaaa aatatattgg ttactgggaa     1980

aaggtcaaga aagaggcaga aagagatcag ggagggctaa agttgtgtct tatgccaagc     2040

gaaagtgaaa aatatcattt tcactttatc aactgagact ttggggcctg taagcttgag     2100

gcaagacaga aataagagaa tcaagacttg attgtaaaaa ttgacaactt tagattctga     2160

ggctaggctg agtacttatt atacggctac atttacacat ttacacttat ctaataaatc     2220

agatttcaca gtctcaaaaa aaaaaaaa                                        2248


<210>  1010
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  1010

Met Ala Leu Leu Phe Ser Leu Ile Leu Ala Ile Cys Thr Arg Pro Gly 
1               5                   10                  15      


Phe Leu Ala Ser Pro Ser Gly Val Arg Leu Val Gly Gly Leu His Arg 
            20                  25                  30          


Cys Glu Gly Arg Val Glu Val Glu Gln Lys Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asp Gly Trp Asp Ile Lys Asp Val Ala Val Leu Cys Arg Glu 
    50                  55                  60                  


Leu Gly Cys Gly Ala Ala Ser Gly Thr Pro Ser Gly Ile Leu Tyr Glu 
65                  70                  75                  80  


Pro Pro Ala Glu Lys Glu Gln Lys Val Leu Ile Gln Ser Val Ser Cys 
                85                  90                  95      


Thr Gly Thr Glu Asp Thr Leu Ala Gln Cys Glu Gln Glu Glu Val Tyr 
            100                 105                 110         


Asp Cys Ser His Asp Glu Asp Ala Gly Ala Ser Cys Glu Asn Pro Glu 
        115                 120                 125             


Ser Ser Phe Ser Pro Val Pro Glu Gly Val Arg Leu Ala Asp Gly Pro 
    130                 135                 140                 


Gly His Cys Lys Gly Arg Val Glu Val Lys His Gln Asn Gln Trp Tyr 
145                 150                 155                 160 


Thr Val Cys Gln Thr Gly Trp Ser Leu Arg Ala Ala Lys Val Val Cys 
                165                 170                 175     


Arg Gln Leu Gly Cys Gly Arg Ala Val Leu Thr Gln Lys Arg Cys Asn 
            180                 185                 190         


Lys His Ala Tyr Gly Arg Lys Pro Ile Trp Leu Ser Gln Met Ser Cys 
        195                 200                 205             


Ser Gly Arg Glu Ala Thr Leu Gln Asp Cys Pro Ser Gly Pro Trp Gly 
    210                 215                 220                 


Lys Asn Thr Cys Asn His Asp Glu Asp Thr Trp Val Glu Cys Glu Asp 
225                 230                 235                 240 


Pro Phe Asp Leu Arg Leu Val Gly Gly Asp Asn Leu Cys Ser Gly Arg 
                245                 250                 255     


Leu Glu Val Leu His Lys Gly Val Trp Gly Ser Val Cys Asp Asp Asn 
            260                 265                 270         


Trp Gly Glu Lys Glu Asp Gln Val Val Cys Lys Gln Leu Gly Cys Gly 
        275                 280                 285             


Lys Ser Leu Ser Pro Ser Phe Arg Asp Arg Lys Cys Tyr Gly Pro Gly 
    290                 295                 300                 


Val Gly Arg Ile Trp Leu Asp Asn Val Arg Cys Ser Gly Glu Glu Gln 
305                 310                 315                 320 


Ser Leu Glu Gln Cys Gln His Arg Phe Trp Gly Phe His Asp Cys Thr 
                325                 330                 335     


His Gln Glu Asp Val Ala Val Ile Cys Ser Gly 
            340                 345         


<210>  1011
<211>  2325
<212>  DNA
<213>  Homo Sapiens

<400>  1011
actcctggct ggggtgggac agggtggcca gataaaagca gagcaggacc tggaaagctg       60

gtttgtatgg gctgcagcct gccgctgagc tgcatcatgg tgcggtctgt ggcctgggca      120

ggtttcatgg tcctgctgat gatcccatgg ggctctgctg caaaactggt ctgctacttc      180

accaactggg cccagtacag acagggggag gctcgcttcc tgcccaagga cttggacccc      240

agcctttgca cccacctcat ctacgccttc gctggcatga ccaaccacca gctgagcacc      300

actgagtgga atgacgagac tctctaccag gagttcaatg gcctgaagaa gatgaatccc      360

aagctgaaga ccctgttagc catcggaggc tggaatttcg gcactcagaa gttcacagat      420

atggtagcca cggccaacaa ccgtcagacc tttgtcaact cggccatcag gtttctgcgc      480

aaatacagct ttgacggcct tgaccttgac tgggagtacc caggaagcca ggggagccct      540

gccgtagaca aggagcgctt cacaaccctg gtacaggact tggccaatgc cttccagcag      600

gaagcccaga cctcagggaa ggaacgcctt cttctgagtg cagcggttcc agctgggcag      660

acctatgtgg atgctggata cgaggtggac aaaatcgccc agaacctgga ttttgtcaac      720

cttatggcct acgacttcca tggctcttgg gagaaggtca cgggacataa cagccccctc      780

tacaagaggc aagaagagag tggtgcagca gccagcctca acgtggatgc tgctgtgcaa      840

cagtggctgc agaaggggac ccctgccagc aagctgatcc ttggcatgcc tacctacgga      900

cgctccttca cactggcctc ctcatcagac accagagtgg gggccccagc cacagggtct      960

ggcactccag gccccttcac caaggaagga gggatgctgg cctactatga agtctgctcc     1020

tggaaggggg ccaccaaaca gagaatccag gatcagaagg tgccctacat cttccgggac     1080

aaccagtggg tgggctttga tgatgtggag agcttcaaaa ccaaggtcag ctatctgaag     1140

cagaagggac tgggcggggc catggtctgg gcactggact tagatgactt tgccggcttc     1200

tcctgcaacc agggccgata ccccctcatc cagacgctac ggcaggaact gagtcttcca     1260

tacttgcctt caggcacccc agagcttgaa gttccaaaac caggtcagcc ctctgaacct     1320

gagcatggcc ccagccctgg acaagacacg ttctgccagg gcaaagctga tgggctctat     1380

cccaatcctc gggaacggtc cagcttctac agctgtgcag cggggcggct gttccagcaa     1440

agctgcccga caggcctggt gttcagcaac tcctgcaaat gctgcacctg gaattgagtc     1500

gctaaagccc ctccagtccc agctttgagg ctgggcccag gatcactcta cagcctgcct     1560

cctgggtttt ccctgggggc cgcaatctgg ctcctgcagg cctttctgtg gtcttccttt     1620

atccaggctt tctgctctca gccttgcctt ccttttttct gggtctcctg ggctgcccct     1680

ttcacttgca aaataaatct ttggtttgtg cccctcttcc caaagatgtg gtgacttaag     1740

aggctctcta agcacactgt tgactccaaa acatccgcag gtcagagcca ggtgggaagg     1800

tggtccgtgc aggatgtgcc aggccctgtg gcaggtcttg ccccatgagt ccatatgcca     1860

gtgggcagtt tccagtacac aggtgatggc agccagagcg cggccccaag tgcaacacgt     1920

tctttggtta ttggctcaga agcctggaaa caggagcttc tgcggacctt cacgcacgtg     1980

ttattcccaa aatgccacta gatggcagca gagaagaact tttccctgat ttaagcgctc     2040

tgcgagcagc cactcagcat tacactaaga attcagaccc ctggtactca ggggtcttcg     2100

agataaatcc tgtttgggcc ctttgcaggc cctatctcac ctactgcccc cgttcaccag     2160

atgaagaagg aacaatgatt attctcactt tataggcatt taaactgaag actgattcta     2220

accaattctg agtccagaac caaggcctga aatgggccag agagcatgca cacggtgtcc     2280

tggttaaata aagtcatccc aacattcaaa aaaaaaaaaa aaaaa                     2325


<210>  1012
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  1012

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Asn Pro Lys Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Thr Gln Lys Phe Thr Asp Met Val Ala Thr 
            100                 105                 110         


Ala Asn Asn Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg 
        115                 120                 125             


Lys Tyr Ser Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser 
    130                 135                 140                 


Gln Gly Ser Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln 
145                 150                 155                 160 


Asp Leu Ala Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp 
            180                 185                 190         


Ala Gly Tyr Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn 
        195                 200                 205             


Leu Met Ala Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser 
225                 230                 235                 240 


Leu Asn Val Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro 
                245                 250                 255     


Ala Ser Lys Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr 
            260                 265                 270         


Leu Ala Ser Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser 
        275                 280                 285             


Gly Thr Pro Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln 
305                 310                 315                 320 


Lys Val Pro Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp 
                325                 330                 335     


Val Glu Ser Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu 
            340                 345                 350         


Gly Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe 
        355                 360                 365             


Ser Cys Asn Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu 
    370                 375                 380                 


Leu Ser Leu Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro 
385                 390                 395                 400 


Lys Pro Gly Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln 
                405                 410                 415     


Asp Thr Phe Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg 
            420                 425                 430         


Glu Arg Ser Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln 
        435                 440                 445             


Ser Cys Pro Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr 
    450                 455                 460                 


Trp Asn 
465     


<210>  1013
<211>  5361
<212>  DNA
<213>  Homo Sapiens

<400>  1013
actcatagaa actggaggca aaatgcatga cagtaacaat gtggagaaag acattacacc       60

atctgaattg cctgcaaacc caggttgtct gcattcaaaa gagcattcta ttaaagctac      120

cttaatttgg cgcttatttt tcttaatcat gtttctgaca atcatagtgt gtggaatggt      180

tgctgcttta agcgcaataa gagctaactg ccatcaagag ccatcagtat gtcttcaagc      240

tgcatgccca gaaagctgga ttggttttca aagaaagtgt ttctattttt ctgatgacac      300

caagaactgg acatcaagtc agaggttttg tgactcacaa gatgctgatc ttgctcaggt      360

tgaaagcttc caggaactga atttcctgtt gagatataaa ggcccatctg atcactggat      420

tgggctgagc agagaacaag gccaaccatg gaaatggata aatggtactg aatggacaag      480

acagttagtc atgaaagaag atggtgccaa cttgtatgtt gcaaaggttt cacaagttcc      540

tcgaatgaat ccaagacctg tcatggtttc ctatcctggg agcaggagag tgtgcctatt      600

tgaatgacaa aggtgccagt agtgccaggc actacacaga gaggaagtgg atttgttcca      660

aatcagatat acatgtctag atgttacagc aaagccccaa ctaatcttta gaagcatatt      720

ggaactgata actccatttt aaaatgagca aagaatttat ttcttatacc aacaggtata      780

tgaaaatatg ctcaatatca ctaataactg ggaaaataca aatcaaaatc atagtaaaat      840

attacctgtt ttcatggtgc taatattacc tgttctccca ctgctaatga catacccgag      900

actgagtaat ttataaataa aagagattta attgactcat agttccacat ggctggggag      960

gtcttgcaat catgacagaa ggcaaatggg aagcaaagtc atgtcttatg tggtggcagg     1020

cagggggact tgtgcacagg aactcctatt tatacaacca tcagatatct tgagacaaga     1080

acagtatggg gctccctggt gtgattccgt cctgcgcggc tgttctctgg agcagcattc     1140

atttatcttc gtctgccttg tctcctacct aagtgtgtgt cgccacccga tggaagattc     1200

gatggacatg gacatgagcc ccctgaggcc ccagaactat cttttcagtt gtgaactaaa     1260

ggccgacaaa gatgatcact ttaaggtgga taatgatgaa aatgagacca gttatcttta     1320

agaacggtca gctcaggggc tggtgcaaag gatgaactgc acattgttga agcagaggcc     1380

atgaatgacg aaggcagtcc aattaaagta acactggcaa ctttgaaaat gtctgtacag     1440

ccaacggttt ctcttggggg ctttgaaata acaccaccag tggacttaag gttgaagtgt     1500

ggttcagggc cagtgcatat tagtggacag cacttagtag ctgtgaagga aggtgcagag     1560

tcagaagatg aagaagagga ggatgtgaaa ctcttaagta tatctggaaa gcagtctgcc     1620

cctggaggtg ggcagaaaaa agtaaaactt gctgctgctg ctgatgatga tgatgatgaa     1680

gatgatgatg atgatgatga cgaggaagct gaagaaaaag cgccagtgaa gaaatctata     1740

cgagatactc cagccaaaaa tgcacaaaag tcaaatcaga atggaaaaga ctcaaaacca     1800

tcatcaacac caagatcaaa aggacaagaa tccttcaaaa aacaggaaaa atctcctaaa     1860

acaccaaaag gatctagttc tgtagaagac attaaagcaa aaatgcaagc aagtatagaa     1920

aaacgtggtt ctcttcccaa agtggaaacc aagttcatca attatgtgaa gaatttcttc     1980

tggatgactg accaagaggc tattcaagat ctctggcagt ggaggaagtc tctttaagaa     2040

aatagtttaa acaatttgtt aaaaattttc catcttattt catttctgta acagttgata     2100

tctggctgtc ctttttatag tgcagagtga gaactttccc taccatgttt gataaatgtt     2160

gtccaggttc tattgccaag aatgtgttgt ccaaaatgcc tgtttagttt ttaaagatgg     2220

aactccaccc tttgcttggt tttaagtatg tatgggatgc tatgatagga catagtagta     2280

gcagtggtca gacatggaaa tggtggggag acaaaagtat acacgtgaaa taaaactcag     2340

tattttaata aagtaaaaaa aaaaaaaaag gtatggggaa aactgccccc ataaagcaat     2400

tgtctccacc tggccctgcc ctttgcatgt ggagattatt acaattcaag gtgaaatttg     2460

ggtggagaca caaccaaacc atatcagatg gctatatcaa aaagacaaga aataacaagc     2520

attggtgaga gtgtggagaa gacggaaccc ttgtacacag ttggtgggaa cacagtttgg     2580

tgcagccatt atagaaaacg tcatggaggt tcctaaagaa attaaaaaga gaactaccat     2640

atgagccagc aatccctttt ccagatatac acccaaagga aatgaaatca ccacctcata     2700

aagatatctg ctttcctgtt tattataaca catctttatt cataatagcc aagatacgga     2760

actaactgaa gtgaccatta acagatgaat ggataaagaa attgtcatat atataaaaca     2820

cacacattat atacatacat acatatatat atatatataa aaaatagaat attattcagc     2880

cttgtaaaaa gaaatcctgt tatgttggga acaagccccc caaaatctgg ccataaactc     2940

accccaaaac tggccataaa caaaatctct gcagcactgt gacatgttag tgatggccat     3000

aacacccacg ctggaaggtt gtgggtttat gggaatgagg gcaaggaaca cctggcctgc     3060

ccagggtgga aaaccactta aaggcgttct taagctacaa acaatagcat gagcgatctg     3120

tgccttaagg acatgttcct gctgcagtta actagcccaa tctattcctt taattcggcc     3180

catcccttca tttcccataa gggatacttt tagttaattt aatatctata gaaacaatgc     3240

taatgactgg cttgctgtta ataaatacat gggtaaatct ctgttctggg ctctcagctc     3300

tgaaggctgt gagacccctg atttcccact tcacacctct atatttctgt gtgtgtgtct     3360

ttagttcctc tggcgctgct gggttaggat ctacccgact gagctggtct cagcactgtt     3420

atttgaaaca atgtaaataa acctataggg tttattatat atactaagtg aaataagcca     3480

gacacagaaa aaaaatgttg catgatctca cttatagtga aacttaaaaa aaaaacccaa     3540

atacatagaa atagagtaga atggtggtta ccagagatga ggaaaataca gagacacagg     3600

tcaaaagata cagagttgca gttacaaagg gtgagtatgt ctagatatct aacatacagt     3660

atgaggacta taatagtatt gcactgtgta ctgaaaactt gatgacagat tttagatatt     3720

cttaccacac agacaaaaag aaatgtaagt atgtgagatg aagcttatgt taattagatt     3780

aagtgtatgt acataaaaac atcacattat acacatcaaa tatatacaat aaaaaagcac     3840

attgggagat acatgataaa tttctatctg cagttgctat ttgcattttt aaaggatatt     3900

tttatttttt aaatttttag ctgacaactg tataattatg gaatacaatg tgatgttctg     3960

atatatgtgt acactatgga atgattaaat caaactaaca tttcatcatc tcacatactt     4020

atcattttct gtggtgagaa catttgaaat ttattctctt gacaattttg aaagatccaa     4080

tacactatta ttaactatag tcactatgct gtgcaataga tctcaaaagc ttattcctct     4140

taactgaaac ctactaccct gtgacatgtg gggaacatct ctctattccc cagccccagt     4200

ccctaaatgt tgaatacaca atggggaaaa aatagtcttc aatgaatggt ggtgggaaaa     4260

ttgtatatcc acatgcagaa gaataaaatt ggacccttac ctcctaccat atataaaaac     4320

caactgaaaa tcgattaaag acttaaactg taaaactact aaaagaaaat atagggagaa     4380

agcttcacaa cgttggtctg ggcaataatt tttggatttg acctcaaaag tagatgcaac     4440

cacagtgaaa ataaacaaat gaaattgcat aaaataaaaa atgtttctgc acagcaaagg     4500

aaataattaa tggagtaaag agacaactta cagattggga gaatatattt ccaaactatt     4560

gttggggctc agaaacggat accctaacat atagtgattt gacaggtgga actaaagaag     4620

actcgaggtc tctctgacct cctcctcaac ctctgtttct taatcctctg ttttcccaga     4680

gcacaggagg aagttctctg aagttccttt atctgcttta agttcagact caccaaataa     4740

gaaaacagtt aattctggtg ccttccatgg gttttcatta actgaagtca tattgtagga     4800

aaaagaatga agtctcttaa cccacctgga tagatttttc tcacaaacca ttgtcttctc     4860

tgcaagccca gtagactttg tcccaggcca tttatgtgat cttcacccca ttaagttctc     4920

cccaaattat ttactcttcc cccaaaatca cccacacttc cccatctccc tctcccctaa     4980

ggacaagggt atatcaccat ctatacccca ttgcttggtg gggtgatcac tctgattctc     5040

tgcatgcatt tttatagatt tgtttgccat ttatcctatt aatctgcatt ctgtcaattg     5100

tggcaagtta tcagcatatt ttttaacttt taattattct taatggaaag acacttctgt     5160

atacactgga aatctcagga aatttctttt ttccttaagc ttaattgaaa tgtttacttt     5220

tcagtaaaat ttcaagcttg agtaatgttc atgcctgctt ttcattgaaa tagaatgaaa     5280

aggttgcaca atattatttt catgaaatta cttctagtat aattctgaat aaacactttg     5340

aaaggcagtg aactgtaaat a                                               5361


<210>  1014
<211>  194
<212>  PRT
<213>  Homo Sapiens

<400>  1014

Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Thr Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Thr Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Thr Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Thr Lys Asn Trp 
                85                  90                  95      


Thr Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Thr Glu Trp Thr Arg Gln Leu Val Met Lys Glu Asp 
145                 150                 155                 160 


Gly Ala Asn Leu Tyr Val Ala Lys Val Ser Gln Val Pro Arg Met Asn 
                165                 170                 175     


Pro Arg Pro Val Met Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu 
            180                 185                 190         


Phe Glu 
        


<210>  1015
<211>  940
<212>  DNA
<213>  Homo Sapiens

<400>  1015
gctgtggccc tggcacctgc ccctgggctg ggacagccca ctgttccatg ctgcccaaga       60

aggctcagca caggcacaaa ccattgcccg gcactggccc gtgctgcctg agaaggattg      120

gcacgggcac agaccactgc ccccacctgc cctgcgccat ctacccaaga aggctcggca      180

cgggcaccaa ccactgcctc caactgcccc atgctgcctg agaaggcact gcacggccac      240

ccccaactgc cccgcactgt ccctacccgg gcagccatgc gagcggctgg aactctgctg      300

gccttctgct gcctggtctt gagcaccact gggggccctt ccccagatac ttgttcccag      360

gaccttaact cacgtgtgaa gccaggattt cctaaaacaa taaagaccaa tgacccagga      420

gtcctccaag cagccagata cagtgttgaa aagttcaaca actgcacgaa cgacatgttc      480

ttgttcaagg agtcccgcat cacaagggcc ctagttcaga tagtgaaagg cctgaaatat      540

atgctggagg tggaaattgg cagaactacc tgcaagaaaa accagcacct gcgtctggat      600

gactgtgact tccaaaccaa ccacaccttg aagcagactc tgagctgcta ctctgaagtc      660

tgggtcgtgc cctggctcca gcacttcgag gtgcctgttc tccgttgtca ctgacccccg      720

cctcttcagc aagaccacag ccatgacaaa caccaggatg catgctcctt gtcccctccc      780

acccgcctca tgacccagcc tcacagaccc tctcaggcct ctgacgagtg agcgggtgaa      840

gtgccactgg gtcaccgcag ggcagctgga atggcagcat ggtagcacct cctaacagat      900

taaatagatc acatttgctt ctaaaattaa aaaaaaaaaa                            940


<210>  1016
<211>  145
<212>  PRT
<213>  Homo Sapiens

<400>  1016

Met Arg Ala Ala Gly Thr Leu Leu Ala Phe Cys Cys Leu Val Leu Ser 
1               5                   10                  15      


Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys Ser Gln Asp Leu Asn Ser 
            20                  25                  30          


Arg Val Lys Pro Gly Phe Pro Lys Thr Ile Lys Thr Asn Asp Pro Gly 
        35                  40                  45              


Val Leu Gln Ala Ala Arg Tyr Ser Val Glu Lys Phe Asn Asn Cys Thr 
    50                  55                  60                  


Asn Asp Met Phe Leu Phe Lys Glu Ser Arg Ile Thr Arg Ala Leu Val 
65                  70                  75                  80  


Gln Ile Val Lys Gly Leu Lys Tyr Met Leu Glu Val Glu Ile Gly Arg 
                85                  90                  95      


Thr Thr Cys Lys Lys Asn Gln His Leu Arg Leu Asp Asp Cys Asp Phe 
            100                 105                 110         


Gln Thr Asn His Thr Leu Lys Gln Thr Leu Ser Cys Tyr Ser Glu Val 
        115                 120                 125             


Trp Val Val Pro Trp Leu Gln His Phe Glu Val Pro Val Leu Arg Cys 
    130                 135                 140                 


His 
145 


<210>  1017
<211>  6358
<212>  DNA
<213>  Homo Sapiens

<400>  1017
aatgattgaa gatagtggga aaagaggaaa taccatggca gaaagaagac agctgtttgc       60

agagatgagg gctcaagatc tggatcgcat ccgactctcc acctacagaa cagcatgcaa      120

gcttaggttt gttcagaaga aatgcaattt gcacctggtg gacatatgga atgtcataga      180

agcattgcgg gaaaatgctc tgaacaacct ggacccaaac actgaactca acgtgtcccg      240

cttagaggct gtgctctcca ctatttttta ccagctcaac aaacggatgc caaccactca      300

ccaaatccat gtggagcagt ccatcagcct cctccttaac ttcctgcttg cagcgtttga      360

tccggaaggc catggtaaaa tttcagtatt tgctgtcaaa atggctttag ccacattgtg      420

tggagggaag atcatggaca aattaagata tattttctca atgatttctg actccagtgg      480

ggtgatggtt tatggacgat atgaccaatt ccttcgggaa gttctcaaac tacccacggc      540

agtttttgaa ggtccttcat ttggttacac agaacagtca gccagatcct gtttctccca      600

acagaaaaaa gtcacgttaa atggtttctt ggacacgctt atgtcagatc ctcccccgca      660

gtgtctggtc tggttgcctc ttctgcatcg actagcaaat gtggaaaatg tcttccatcc      720

ggttgagtgt tcctactgcc acagtgagag tatgatggga tttcgctacc gatgccaaca      780

gtgtcacaat taccagctct gtcaggactg cttctggagg ggacatgccg gtggttctca      840

tagcaaccag caccaaatga aagagtacac gtcatggaaa tcacctgcta agaagctgac      900

taatgcatta agcaagtccc tgagctgtgc ttccagccgt gaacctttgc accccatgtt      960

cccagatcag cctgagaagc cactcaactt ggctcacatc gttgatactt ggcctcccag     1020

acctgtaacc agcatgaacg acaccctgtt ctcccactct gttccctcct caggaagtcc     1080

ttttattacc aggagctctc ctcccaagga cagtgaagta gagcagaaca aactgctggc     1140

tagggctgct ccagcttttc tgaagggcaa agggatacag tacagcctga atgtggcaga     1200

caggctagct gatgaacatg ttctcatcgg gttgtatgtc aacatgctcc ggaacaaccc     1260

ctcatgcatg cttgagagtt caaaccggct tgatgaagaa cacaggctaa ttgccaggta     1320

tgcggcaagg ctggcagcag agtcctcttc gtctcagcca cctcagcaga gaagtgctcc     1380

tgacatctct ttcaccatcg atgcgaataa gcagcaaagg cagctgattg ctgagctaga     1440

aaacaagaac agagaaatct tacaggagat ccagagactt cggctagagc atgaacaagc     1500

ttctcagccc acgccagaga aggcacagca aaaccccacc ctgctggcag aactccggct     1560

cctcagacag cgcaaagatg agctggaaca gagaatgtct gctctccagg agagccggag     1620

agagctaatg gtccagttgg agggtctcat gaagctacta aagactcagg gggcaggctc     1680

tccccgctcc tcccccagcc acaccatcag caggccaatt cccatgccca tccggtcagc     1740

gtcagcctgc tccaccccga cgcacacgcc gcaggactcc ctcacaggag tagggggaga     1800

tgtacaagag gcatttgcac aaagttcaag aagaaactta aggaatgact tgctagtggc     1860

tgcagattcc atcactaaca ctatgtcctc tcttgtgaaa gagctgaatt ctgaggttgg     1920

gagtgaaaca gagagtaatg tggattctga atttgcacgg actcagtttg aggatcttgt     1980

tccctcacca acctctgaaa aggcttttct agcgcaaatc catgcccgaa aacctgggta     2040

cattcacagt ggagctacca caagtaccat gcgtggcgac atggttacgg aggatgcaga     2100

tccctatgtg cagcctgaag atgaaaacta tgaaaatgac tctgtccggc agctggagaa     2160

tgagctccag atggaggaat acctgaaaca gaagctgcaa gatgaagctt atcaggtcag     2220

cttgcaaggt tgaatgcaat atccttttat cacactcctc tcaagcaagc tatagtcaga     2280

cagatgatga aagtaacatg aaaactggtg atgatggaga gccctgtggc cacacagagg     2340

aggaagacag cagcctggca gcagcctcac cgaagagagg aaccaccaca cccagcagct     2400

cctgacagac ccccacccct aaagatgtgt cctgatgact atagtgcagc taactttttg     2460

ttctcagatt tgtagtgcat aggtgtgtgt ttcaagaagg aaaaaaaaag acttctgttc     2520

aaagttaact tatcagctac atcctctgta acgtggttca tccctggtta aaaagcaaac     2580

aaacacaggc tgaaaaccca tgctgctgtt atacacaatg gcagtattaa caagcatttt     2640

aaacctttgc acatgatatt gaacctgttc agtttacaat gacaatatta atactgttta     2700

tagctagaag tttgatttct gaattctttg agattttagc aaaacagttt attatacact     2760

gtacattttt ttcacagcaa ttggaaaaaa acaaccactt gcaatcattc aataaccctg     2820

aagaatttgg ttcctgagtg tacaaactca gagcccggaa gccaagaagg gtccttggcc     2880

tgcacggtct gtagttgact ccaagtctct gtgagcagtg acttgaacca aacacaccag     2940

gaataatcca ttctttgggg cctctttcca actcgaggtt gttttctttc aagatactct     3000

aatcagccat agaatttagt gtaaatattt ttttttccaa atagatatca tattcaaaaa     3060

aggcagcatt caaattatat agaatctagt ttttaaaatc agcacagatc ttcttaaaaa     3120

ctgtgaacta tgttttgaaa tactcgttac taaagctgtt tataaaccac aggtgccata     3180

agatccccaa acggactaaa gttatctctg ctcttccatg gtcttgttcc tctcgttttg     3240

gctttaggaa gcatgtcttt aacagcaccg ctcgttcaca agttccccca tcaagttgtt     3300

tggaggcctt cagctttaaa tgtacaggct taaagtgcgc ttgcaaacgt ttgctctcct     3360

ttttttctga atgttgattg ccttagctgg ccacctggtg ttctgcatgt agccttctgt     3420

ggtcatgtga aaggagacag gctcttctaa gttgagttgg gatttttgca ctcagtgaaa     3480

agctgaagtg caaaagagct atcaaagaca agaggataaa agactgggat agtcttttcc     3540

aaggaccctc tttagagggc cctaaagacc tcctttggga attctgggga aaaagaaaaa     3600

gtaatcttct acttgcttca agatttgatt tttttaaaaa agcctgcgac ctattcaata     3660

cattatgctt aaattagcag tttctctgga attcctgtct ctcctttaaa agaaaggaga     3720

gaacatttta gaacaatagt tctcaaagtg tgttccccgg acaagcagca tctgcaacac     3780

ttaggaaggt cttcgaaata ctaatttgta agccccacct caggcctact gaatcagaag     3840

ctctgggggt tgggtccaga agtctgtttt agtcaaccct ctaggtgatt ctgatgctcg     3900

ctaaaggttg agaactactg ctttagaatg aagtcgtata ataaagtctc tgaaaaggcc     3960

ttattcagaa taagcaagaa aggttctgtg attcactttt gcttctgggg ctggcaaaaa     4020

ccttctctga acccacacac caagttcgta gttggtaggt gcccagccaa gtcctgacat     4080

cttcatgccc cctctgcaga gggcggctgt acgatgttca catgtctgcg tttggtcaga     4140

catcatctcc ttggctgccc tttgaaacca aatcacttgc cttggggata aagtgctcaa     4200

ttggcattag tgagaagccc atcctatccc ttgacatact taatcatata tctctccaga     4260

gaactcacct gacaaatgtc tctgagcaca ggctgacacc aaagtggcac aactgcacag     4320

ttctcagatt tctttgcaca gattgatttt tattgcgggt tttgttgggg tgtcttaatg     4380

ttcatctctt ttccactgcc catcctctgt gaacccatac ctctctagat ggagcaggtg     4440

gccactggtg cctcatactc agtattgaaa accactacat cccagctacc tataatgctg     4500

tcagctcaaa atcatagcca ggtagttctt gaactcagaa cttaaatcct gcacgtggca     4560

ctccaccact gactggaccg agctggcata tgttgtttct ttgtgtttct acatcaaaat     4620

gttcgtctaa gatttgaact gttctgctga taaccttccc cgttgtcata gctatttcat     4680

tgccaaccaa ctccatcaca tggttgttga tatcgtcata taaagccatt gcaaggactc     4740

tggaaactgc cgccaatgac caatttctga ctaaccagcc accttttctc tctcttagct     4800

ccacgtcagc actgagacca gactcgagca cccctgtcct gtaagcgaga caaaatggcg     4860

tgtgttattt tggggttttg tgttttttgg tgggtttctt tccttggctc tccagattta     4920

cttttggggc ctgttctaag tgcaaaccca gcaagtttca cttgtcctgt ccattagata     4980

caactacatc ttgcgggggt tgtttctttc ttgttccaca atgaattgca catccatctc     5040

catcagagct gatagcctgt taataagcac tggtctaaca cagccaaccc tcctccacag     5100

cgccatatta atggaggagg ggaggaaggt gaaatctact gcatgggatt caggaaacag     5160

ttgtggttgg tcaggacgga agttggggta agtttggttg gtcagaggga gttgtgctgg     5220

agattgtgaa aaatgggttc ttgaatgatc tactataagg cagggaaggt tcatttgtaa     5280

gtagtaatgt gaactgaatt gcattaagag tgtgtggcct ttgttgtgat atactatgta     5340

ttttcttata tgcatgagcc aaactgttgc atcataattt agcactgatg tctgctttta     5400

ttttgatcat ctttgtccac ccttattagt tcttggctgt taaccgtaga tagatcttgt     5460

aaatccagca acctttggtt gctgcattcc ccttggttcg attccacgca aggagccaca     5520

agtgagaact ccactgtcct tagaagaaag ggcattttta cttttgaacc aaaaagagaa     5580

aaaaaaatca gaagtgttgc atcttgaggc gaattaactg taagacattt ttaattatga     5640

ctactgcaat ttgacaccat ttgaaataat caattcagag acactaaaga tttcacaata     5700

ttcattggta ttgtaaaaaa aaaatactat tgtatggatt tttgtattgc tgttaagtat     5760

tgttttgtgt gtgtgtgtgt gtgtgtgtgt tggaacctcc tggggacatg ttatattttg     5820

aagtgattaa actatttaat tgtgtgtcta tattttggag tggaataatt tcttcattaa     5880

aaaatgtttt taaaaacact atatcttggg tggtttattc ctttgtttca gtgaatcttt     5940

cctaaagcaa cgtggagtca gtctgttgaa agaaggaagg caggtacttg cagtttaaag     6000

caggacccat tgatggaata ttgagccacc gaggcaaaat agctcacctt ctcttgcctt     6060

gggggatgca tggtttttac cattctactg ttttattagc atctgtgagc atctaataga     6120

aatactattc tgctatttat ggaaatcctt attataattg atatggaagt gagtttgaaa     6180

ttctaacagc taacatattt catgtttgta tcacacactg ttcttaacac tttatgtgac     6240

ttcactcaat tctttgaatc ctctgcatct agccatgtat tctgcaaata ttaagtgctc     6300

aatggttttt ttgttgaatt actgaataaa tgaattagtg gtgaaaaaaa aaaaaaaa       6358


<210>  1018
<211>  743
<212>  PRT
<213>  Homo Sapiens

<400>  1018

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Asp Thr 
                325                 330                 335     


Trp Pro Pro Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His 
            340                 345                 350         


Ser Val Pro Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Pro Pro 
        355                 360                 365             


Lys Asp Ser Glu Val Glu Gln Asn Lys Leu Leu Ala Arg Ala Ala Pro 
    370                 375                 380                 


Ala Phe Leu Lys Gly Lys Gly Ile Gln Tyr Ser Leu Asn Val Ala Asp 
385                 390                 395                 400 


Arg Leu Ala Asp Glu His Val Leu Ile Gly Leu Tyr Val Asn Met Leu 
                405                 410                 415     


Arg Asn Asn Pro Ser Cys Met Leu Glu Ser Ser Asn Arg Leu Asp Glu 
            420                 425                 430         


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ser 
        435                 440                 445             


Ser Ser Ser Gln Pro Pro Gln Gln Arg Ser Ala Pro Asp Ile Ser Phe 
    450                 455                 460                 


Thr Ile Asp Ala Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu 
465                 470                 475                 480 


Asn Lys Asn Arg Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu 
                485                 490                 495     


His Glu Gln Ala Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro 
            500                 505                 510         


Thr Leu Leu Ala Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu 
        515                 520                 525             


Glu Gln Arg Met Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val 
    530                 535                 540                 


Gln Leu Glu Gly Leu Met Lys Leu Leu Lys Thr Gln Gly Ala Gly Ser 
545                 550                 555                 560 


Pro Arg Ser Ser Pro Ser His Thr Ile Ser Arg Pro Ile Pro Met Pro 
                565                 570                 575     


Ile Arg Ser Ala Ser Ala Cys Ser Thr Pro Thr His Thr Pro Gln Asp 
            580                 585                 590         


Ser Leu Thr Gly Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Ser 
        595                 600                 605             


Ser Arg Arg Asn Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile 
    610                 615                 620                 


Thr Asn Thr Met Ser Ser Leu Val Lys Glu Leu Asn Ser Glu Val Gly 
625                 630                 635                 640 


Ser Glu Thr Glu Ser Asn Val Asp Ser Glu Phe Ala Arg Thr Gln Phe 
                645                 650                 655     


Glu Asp Leu Val Pro Ser Pro Thr Ser Glu Lys Ala Phe Leu Ala Gln 
            660                 665                 670         


Ile His Ala Arg Lys Pro Gly Tyr Ile His Ser Gly Ala Thr Thr Ser 
        675                 680                 685             


Thr Met Arg Gly Asp Met Val Thr Glu Asp Ala Asp Pro Tyr Val Gln 
    690                 695                 700                 


Pro Glu Asp Glu Asn Tyr Glu Asn Asp Ser Val Arg Gln Leu Glu Asn 
705                 710                 715                 720 


Glu Leu Gln Met Glu Glu Tyr Leu Lys Gln Lys Leu Gln Asp Glu Ala 
                725                 730                 735     


Tyr Gln Val Ser Leu Gln Gly 
            740             


<210>  1019
<211>  12740
<212>  DNA
<213>  Homo Sapiens

<400>  1019
agggaagaag ggagaaagag agagagattt gaatatacat tgcttcaagg atgcaaaaaa       60

ttacaacctg gaaaaggctt cgagtaactt taggaaaatg agctgctgga ctcctcagtc      120

aatctgtcct ttctagtcaa tgaaaaagac agggtttgag gttccttccg aaacggggcc      180

ggctaattta gcccctccca cgagcccaag ggtctgttat atctctgttt ccttgaggac      240

ctctctcacg gagacggacc acagcaagca gaggctgggg gggggaaaga cgaggaaaga      300

ggaggaaaac aaaagctgct acttatggaa gatacaaagg agtctaacgt gaagacattt      360

tgctccaaga atatcctagc catccttggc ttctcctcta tcatagctgt gatagctttg      420

cttgctgtgg ggttgaccca gaacaaagca ttgccagaaa acgttaagta tgggattgtg      480

ctggatgcgg gttcttctca cacaagttta tacatctata agtggccagc agaaaaggag      540

aatgacacag gcgtggtgca tcaagtagaa gaatgcaggg ttaaaggtcc tggaatctca      600

aaatttgttc agaaagtaaa tgaaataggc atttacctga ctgattgcat ggaaagagct      660

agggaagtga ttccaaggtc ccagcaccaa gagacacccg tttacctggg agccacggca      720

ggcatgcggt tgctcaggat ggaaagtgaa gagttggcag acagggttct ggatgtggtg      780

gagaggagcc tcagcaacta cccctttgac ttccagggtg ccaggatcat tactggccaa      840

gaggaaggtg cctatggctg gattactatc aactatctgc tgggcaaatt cagtcagaaa      900

acaaggtggt tcagcatagt cccatatgaa accaataatc aggaaacctt tggagctttg      960

gaccttgggg gagcctctac acaagtcact tttgtacccc aaaaccagac tatcgagtcc     1020

ccagataatg ctctgcaatt tcgcctctat ggcaaggact acaatgtcta cacacatagc     1080

ttcttgtgct atgggaagga tcaggcactc tggcagaaac tggccaagga cattcaggtt     1140

gcaagtaatg aaattctcag ggacccatgc tttcatcctg gatataagaa ggtagtgaac     1200

gtaagtgacc tttacaagac cccctgcacc aagagatttg agatgactct tccattccag     1260

cagtttgaaa tccagggtat tggaaactat caacaatgcc atcaaagcat cctggagctc     1320

ttcaacacca gttactgccc ttactcccag tgtgccttca atgggatttt cttgccacca     1380

ctccaggggg attttggggc attttcagct ttttactttg tgatgaagtt tttaaacttg     1440

acatcagaga aagtctctca ggaaaaggtg actgagatga tgaaaaagtt ctgtgctcag     1500

ccttgggagg agataaaaac atcttacgct ggagtaaagg agaagtacct gagtgaatac     1560

tgcttttctg gtacctacat tctctccctc cttctgcaag gctatcattt cacagctgat     1620

tcctgggagc acatccattt cattggcaag atccagggca gcgacgccgg ctggactttg     1680

ggctacatgc tgaacctgac caacatgatc ccagctgagc aaccattgtc cacacctctc     1740

tcccactcca cctatgtctt cctcatggtt ctattctccc tggtcctttt cacagtggcc     1800

atcataggct tgcttatctt tcacaagcct tcatatttct ggaaagatat ggtatagcaa     1860

aagcagctga aatatgctgg ctggagtgag gaaaaaaatc gtccagggag cattttcctc     1920

catcgcagtg ttcaaggcca tccttccctg tctgccaggg ccagtcttga cgagtgtgaa     1980

gcttccttgg cttttactga agcctttctt ttggaggtat tcaatatcct ttgcctcaag     2040

gacttcggca gatactgtct ctttcatgag tttttcccag ctacaccttt ctcctttgta     2100

ctttgtgctt gtataggttt taaagacctg acacctttca taatctttgc tttataaaag     2160

aacaatattg actttgtcta gaagaactga gagtcttgag tcctgtgata ggaggctgag     2220

ctggctgaaa gaagaatctc aggaactggt tcagttgtac tctttaagaa cccctttctc     2280

tctcctgttt gccatccatt aagaaagcca tatgatgcct ttggagaagg cagacacaca     2340

ttccattccc agcctgctct gtgggtagga gaattttcta cagtaggcaa atatgtgcta     2400

aagccaaaga gttttataag gaaatatatg tgctcatgca gtcaatacag ttctcaatcc     2460

cacccaaagc aggtatgtca ataaatcaca tattcctagg tgatacccaa atgctacaga     2520

gtggaacact cagacctgag atttgcaaaa agcagatgta aatatatgca ttcaaacatc     2580

agggcttact atgaggtagg tggtatatac atgtcacaaa taaaaataca gttacaactc     2640

agggtcacaa aaaatgcatc ttccaatgca tatttttatt atggtaaaat atacataaat     2700

ataattcacc attttaacat ttaattcata ttaaatacgt acaaatcagt gacatttagt     2760

acattcacag tgttgtgcca ccatcaccac tatttagttc cagaacattt gcatcatcaa     2820

tacattgtct agagacaaga ctatcctggg taggcagaaa ccatagatct tttgtgttta     2880

cagctatgga aaccaactgt accataaaga tagttcactg agttttaaag ccaagccaca     2940

tcttattttt ccaaggttta atttagtgag agggcagcat tagtgtggag tggcatgctt     3000

ttgccctatc gtggaattta cacatcagaa tgtgcaggat ccaagtctga aagtgttgcc     3060

acccgtcaca caacatgggc tttgtttgct tattccatga agcagcagct atagacctta     3120

ccatggaaac atgaagagac cctgcacccc tttccttaag gattgctgca agagttacct     3180

gttgagcagg attgactggt gatgtttcat tctgaccttg tcccaagctc tccatctcta     3240

gatctgggga ctgactgttg agctgatggg gaaagaaaag ctctcacaca aaccggaagc     3300

caaatgtccc ctatctcttg aatgatcaag tcacttttga caacatccag gtgaatataa     3360

aaacttaata aagctgtgga aaggaactct taatcttctt ttctgctact taggttaaat     3420

tcactagatc ttgattagga atcaaaattc gaattgggac atgttcaaat tctttcttgt     3480

ggtagttgcc tatactgtca tcgctgctgt tggttgagca tttgtggtgt accacgctgt     3540

gtgctcaagg gtattacatt catcttctca tttaatcctc acaacaatct gaagaaggta     3600

ggtattacaa ttcccacttc atagaaacag aaactgaggt tcagagaggt taagtcattt     3660

gcccaaatgg ctgagccaaa gcctaccatg tacctaacct ttattttctt tcccgaacat     3720

accaggctgt ctcctcataa cttccaagca tgcacttaaa actccacatg aatacaaggt     3780

tcatgggact tggtattcat agaaagggag gcagaaagct ggtctgttcc tgataggctt     3840

gtaatttaat atcattctgt tcatgtgctt tggatggaag cacatctggc atatgatgct     3900

aatcagtggt tcccataccc ctggcttcct aattttaatg tttgctcaca gcatagtaga     3960

ttgacatcaa atagtggccg atgatgatga aaataaaggt caaataagtt gagccaataa     4020

cagccgcttt tttccttctg tctgcgtata caaagcactg tcatgcacac aatctattct     4080

gaccctcaca acaacccata agggtgtaaa tagtatttcc attttacaaa tgaggatcac     4140

acaaactact acatggcaga gcagatactc caactcatgt cttctggttg aagcctattg     4200

ctttttcttt tctaaacact ttccctcagc aagttggaat tagacttcac aagtctcctt     4260

cagagaacac aaatcttttc ttattccatt cctgtttggt tgcctacgtc caatctcccc     4320

ctccccagag atgccaaaaa aaaaatcctt taaggtattt gggagccaaa ctcaacttgt     4380

taaaatctca aattatggag acaatcagca gacacaacct aaccccaatt attttggcag     4440

gaaggttggt ttagaggcag atccagcaat ctgctttggg ccactctggg tggggtaggt     4500

gaaataagat tggtcactgt taactaattt taatattgga ttggccattg gttatcactg     4560

attaccattc tcccctggat tttcacccag gactcaaaac ttggttctgc taaccctgtt     4620

cctttatgag gaacctttta aagattcctt tataaggtgg gagttttttt tctatgaacc     4680

tataggggag aaaaaagatc agcagaagtc attacttttt tttttttttt tttttttttt     4740

tgagagagag tctcactcca ttgcccaggc tggagtgcag tggtgctatc tcggctcact     4800

gcaacctccg cctcctgggt tcaagcaatt ctcctgcctc agcctcccga gtagctggga     4860

ttgcaggtgc ccaccaccac acccggctaa tttttgtatt tttagtaaag acagggtttc     4920

accatgttgg ccaggctggt ctccaactcc caatctcagg tgatcctatt gcctcgggct     4980

cccaaagtgc tgggattaca ggagtgagcc accatgcctg gccagaagtg gttacttctg     5040

tagacaaaag aataatgcta cttaatcagg ctttctgtgt gacaagaaag agaaagaaaa     5100

taaagaagtt tcaattcatc caattcttaa taagaaatat gtaaataaaa ttttttaaaa     5160

ttacacttca ttttaatgtt gtatcagtca aggtccctgc aagagatgga tggtatggta     5220

cactcaaact gggtaacaca ggagagtttt cagaaagcaa ctaaatccaa aatactatca     5280

aggaatcaat ataaaaattg ttaatatttt tctcatacta aattttcaaa atattttgtg     5340

tctattacat ttacagcaca tcttaattag gactagctgt gtgttcacct cacatgtggc     5400

ttgtagctac catactggac agcacatgtc caaaaaaata cacgtaaagt taaagtttaa     5460

aagacacagg aactaagccc tcattgtctt tcccttggga ggtagtttaa agagctatag     5520

atgctgtaac attcttgcta ttatttatta tatatgacat tattcctaaa aaagcttttg     5580

agatcctagg ttgtattcct caggttttgt tgccttccca tgaagatgtg aaggcaggga     5640

tgcctgttat tcagtccaag atgcatgaca agagaccttg ggaaagtttc atctggattt     5700

aaagattaat tcttgatgct tacattccat actcaaaatg taaatttgaa tattaaaata     5760

aagatgattt tttttttgga gctagtcttg ctctgttgcc caggctggaa tgcagtggca     5820

tgatcatggc tcactgcagc ctcgacctcc caagctcaag caaggctaca ggtgtgcacc     5880

taagtagcta ggactacagg tgtgcaccac catgtctagc tatttttttt tctgtagaga     5940

cagggttttc ctatgttgtc caggctggtc tcgaactcct gccctcaagc aatcctcctg     6000

ccttggcctc ccaaagtgtt gagattacag gcgtaagcca ctgcacctgg ccaagatgaa     6060

tattttaata gctcacagaa caaagtttgc cacataatga taaaattact atgaaaatat     6120

attcccttta ttgtcagttt aaaagatgaa ctgagtttca cccaaactgg tctggcccct     6180

ctctgattca aataccaata gttgctctga ttcaaattcc aactgttaga acatgacagc     6240

tgctcataac tagctttgct tactaaccat gtttctttcc atttgtatta ggtcctttac     6300

tttttataac agcctcaaag tttcatgaat tgctgcagta aacattgatt ttcatgtttg     6360

tgagtctgca agccagctgg gcagctctac ttcaggtggt aagggtggat cagacctatt     6420

ccatatacct cttgttctcc ttgtccagtg gtttctaggg atatgttctc atgatgaacc     6480

ccgcagaggc tcgtgaaagt gagaggaaac taggatgcct cttaaggtct tggtcaggat     6540

ggggtctcct gtcacttctg tcacaggcta ttgtaagtca tatgagcaag ctcaataaaa     6600

tataaacaag tcagataaac agtgggagga atggcaaagt catatggcca aggccatgag     6660

tgattaattt taacacagga aaaaagtaaa gcattaaatg cgattattta atatacaatg     6720

tcttattaac tgaaatataa aatgtgttta ctgtaaaata taatctgttt atctcaccaa     6780

agaaatatta tctttaaaaa atgtcattac ttctaagaca tcatcagtct gcaacttctt     6840

tccatagcct taatcaggat gctgtggcag ctcccacatt agcctcgcat tctaaactgg     6900

tagatgtcct aggaaaccat acatctatgt atttttctta ttttatacgt ttaggacaat     6960

gtatagctaa ttacccaact ttttatttgc atacaaatct aatacaactg aacacaatca     7020

gttttatcac aggtataatg gatttttcaa tagtgaggag gtgcctccat gagccttctc     7080

tttagaaaag tggcattcaa gactcttcat ttgaagtgaa gattgctatg tcttttgcat     7140

tgctctattt tacataaatt aagttataaa ttgacactat aatcaactga caccatgatc     7200

agtgatgatg atcaccctca tcagcactag agttgacttg tttttataac ccctttgcat     7260

gtatgttgaa tagcaaagtt catcagagaa catgtattag tcaatggtaa gtaagatact     7320

ctcatctaag aaataacatc acctcttcta atgaagttct aagaagagag ggaagaaaaa     7380

gtcttgggag ctagtcaggg aatagtgtgt atttgcaatt acctaaactg aactctacca     7440

ttactcctaa cccagttcct cctcctgtgt tttacatgat taatgccacc cctgcctcaa     7500

tgaaccaaga tcagctccat cactgggacc tccccattct gcctgtgcaa tatttttctt     7560

ttttatttct ccttctaata ttactgttat tgctccagta aagagctgta atatatttta     7620

cctggactga taccaggaat ggtggtgttg cttccaatct gttgctgcta gattaatctt     7680

tgcaaagcac aggcttaatt tcattgctgc tcaactaaaa ccactggtgg ctttccattg     7740

cctacaaaat aaagtcaacc tccccatcag acattcaagg ctttcaatga tccatggccg     7800

ccagctctct ccaggctcat atcccactcc actcctctga tgtttcctac actacactac     7860

actatactac actacagcca ggtagaatga ctgttcaccc aacaccactc aggttgtctt     7920

ctcaacttgg aatactcttg caccttcaaa gctcatttca aatgcccctt catttgtgaa     7980

gccttctcca aatttccaag tcagaatgtc tcttccttgt gctaccacaa ccctttaact     8040

gagcctccat tagtgcactg agaccattct gttcagtgtc tgggtgaagc ttcctggtga     8100

aaaatatgtt acctatttct ttctgaaaag ttggattcag ggatattatc acggacctaa     8160

ggtaatagtt ctagccaacc tccctgtcca ctgccaggcc gactacaaac ccttctgttg     8220

ctggcgagct ggtccgcacc actagttctg cttcactcta tttatctctt gatgtaacca     8280

tcttctttct ccaggtttta agaaccagcc caactcctgg ttccctgatg aagcttttat     8340

tcccctagcc acatggaact tttccttttt ggaacatgcc tttagtttct gtgtagtttg     8400

ccatgcagca cttcattgta cacattatta aaacagaatt ttaaggatta gaatgaacct     8460

taaaagatca tgcatctcaa aatttaatgt acatacaaat tacccaggga ttttgttgaa     8520

ataaaaatta tttaatttta attaatataa ataattcagt aggtctgggg tgaggcctga     8580

ggttttacat ttccaacaag ctgccaggta aagccaatac atctgtccag gaatcacact     8640

ttgcgtatca aaggtctaga tgacattatc attccaaaga gtttctttta caggctctca     8700

gatcagtgtt catccactac ctgactactg tcattcacag gcattctgtt ccacagcagg     8760

ccagctaacg tggtatttac aaagctcact cctcttatac aacaatccaa gtgtttcttt     8820

tgtcagttgt ctgtgcccca ggagatccct ctctgccttg ccttgccctc tgcctttgga     8880

gaccagcacc tcatactcag tgaaggcctg gagtgcttaa gagggatttc ttccagctct     8940

cttgccctgg tcttcagtgt attagatgta ttacctccat gctctcagta gaggcccata     9000

ggaaagagta ggtaggttat gccagctcac acgcatcctt taaaaatggt ttagaagttt     9060

agctggtttc ttattactcc tgtctatgga tgtttccttc tgtcactcta ctagggatga     9120

aacagctaat catgttcaat agttacattt agattggttt ttaaaaacta tgattgtatt     9180

agttcgtttc catgctgctg ataaagacat atctgagact ggaaacaaaa agggtttaat     9240

tggacttaca gttccacatg gctggggagg cctcaaaatc aggtgggagg caaaaggtac     9300

ttcttacgtg gtggcatcaa gagcaaaatg aggaagaagc aaaagcagaa actcttcata     9360

aacccaccag atcttgtggg acttattatc acgagaatag cacagaaaag actggcctcc     9420

atgattcaat tacctcccac tgcgtccctc ccacaacatg tgggaattct gggagataca     9480

attcaagttg agatttgggt ggggacacag ccaaaccata tcattcctcc ctgggctcct     9540

ccaaatttca taatcctcac atttcaaaac caatcattcc ttcccaacag ttccccaaag     9600

tcttaactca tttcagcatt aacccaaaag tccacagtcc aaagtctcat ctgagacaag     9660

gcaagtccct tccacttaca agcctgtaaa agcaagctag ttacctccta gatacaatgg     9720

ggggtacagg tattgggtaa atacagctgt tccaaatgag agaaattggc caaaacaaag     9780

gggttacagg gtccatgcaa gtctgaaatc cagtggggca gtcaaatttt aaagctccat     9840

aatgatctcc tttgactcca tgtctcacat tcaggtcatg ctgatgcaag agataggttc     9900

ccatggtctt gtgcagctcc gcccctgtgg ctttgcagag tacagcctcc ctcctggctg     9960

ctttctcagg ctgatgttga gtgtctgtag cttttccagg cacaagatgc aagttggtgg    10020

ttgatctacc attctggggt ctaccattct ggggtctacc gttctgggac tgtggccttc    10080

ttctcacagc tccactaggc agtgccccaa cagggactct gtgtgggggc tctgccccac    10140

atttcccttc cacactgccc taggagaggt tccccatgag ggctctgccc ctgcagcaaa    10200

cttttgcctg gacatccagg tgtttccata tatattctga aatctaggca gaggttccca    10260

aatctcaatt cttgacatct ctgcacccac aggctcaaca tcacatggaa gctgccaatg    10320

cttggggcct ctaccctctg aagccacagc ccaagctcta tgttggctcc tttcagccat    10380

ggctggagca gctgggacac agggcaccaa gtccctaggc tgcacacagc acagagaccc    10440

tgggcccagc ccacaaaacc actttttcct cctgggcctc tgggcctgtg atgggagggg    10500

ctgccatgaa ggtctctgac atgacctgga gacattttcc ccatggtctt ggggattaac    10560

attaggctcc ttgctgctta tgcaaatttc tgcagccagc ttgaatttct ccttaaaaaa    10620

aatgggtttt tcttttctac tgcatcatca ggctgcagat tttccacatt tatgctcttg    10680

tttccctttt aaaacagaat gtttttaaca gcacccaagt caccttttga atgctttgct    10740

gcttagaaat ttattccacc agatacccta agtcatctct ctcaagctct aagttccaca    10800

aatctctagg gcaagggtga aatgctgcca gtctccttgc taaaacataa caagggtcac    10860

ctttacttca gttcccaaca aggtcttcat ctccatctga gaccacctca gcctggacct    10920

tattgttcat atcactatca gtatttttgt caatgccatt cacagtctct aggaggttcc    10980

aaactttcct acattttcct atcttcttct gagccctcca gattatttca acacccagtt    11040

ccaaagttgc ttccacattt tcgggtatct tttcagcaat gccccactct actggtacta    11100

ttagtccatt ttcatgctgc tgataaagac atacctgaga ctgggaacaa aaagaggttt    11160

aattggactt atagttccac ctggctgggg aggcctcaga atcatggcag gaggtgaaag    11220

gcatttctta cacggcagca gcaagagaaa aatgaagaag cagcaaaagc agaaacccct    11280

gataaaacca tcagatctcg tgagacttat tcactatcac aagaatagca tgggaaagac    11340

cagccccctt gattcaatta cctccccctg ggtcctgtgg gaattctgga aggtacaatt    11400

caagttgaga tttgggtggg gacacagcca aaccatatca atgattttgt actttaacca    11460

gctgaatgga agtacaatct cttgctatat gacacaataa ttatttgcaa aatgagtaaa    11520

catatcataa ggaaattatt tttacaaggt ttgaaacctg aaatgcagtc tattatcata    11580

cataactaaa aatagagcct caataaacag attcccagtt ttgaaaatgc aacatttgta    11640

ctccacattg tcagttttct taggtatatt tataaatact cctataaaaa tgtaaagaaa    11700

cacataatgt agattgctaa ttttataata acacaagttg attttgacat ccaacttatt    11760

aattatgaaa tgacttttgg cctagtaaca atgaaaatgg gggcaaatac agataaatgg    11820

taattcttag aatgaactac tcagcaccaa ttctaagttt ttcttgatgg taaatcataa    11880

tgttcccttt ctcctcggtt ctgcaatcta taggcatacc ataattgtaa tcaatagctt    11940

aaaaatatgt ctctctgtcc tattctgtat ctgtatctct tggattttta cctttgcaat    12000

agtcaactga accatcttct tggagtactc atgaagatgg aagtctacat ggagaataca    12060

ggatgaatcc actctgtctc ctgcagtgaa gtctgtttga aggatgtatt tggctgtctt    12120

ctggacaggc cattctaata acagaaacaa acaagttatt ttaaaactta ttggaatatt    12180

caaatattaa ccaaagtaga aaaatataat acacatccat gtgcccatca cagaacttca    12240

ctgattatca tcatttagcc agtcttgaag aagcaagtgc taattacaat cacaaatgaa    12300

acaagattca gacttcatga agagcactgc gctataataa aagaagaaat gagcacatac    12360

attcttttac tgacagtcaa atggtgaagg tgggcagaat cattatgtga tgcaacatgg    12420

caaaagtata cagacagtgc atccagagga aggcaccttg ctgaatgact agaatggaag    12480

taggagacat tttgcaggcc cccttcatcc tgcagggaga accagaacca cagcagctct    12540

atttgcctat tcctctttaa attacaaagt taaaatttgg gagtagtaga aaatcaattg    12600

gttatcttat agagtctcct agaatatttc attggcattg agaaggtgga aaatgcaaat    12660

tatatacttt aaaatgtaat ttttgctttt cacatatgct taaagcctaa aacctcttaa    12720

taaacttctt ctgaaatata                                                12740


<210>  1020
<211>  510
<212>  PRT
<213>  Homo Sapiens

<400>  1020

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  1021
<211>  4691
<212>  DNA
<213>  Homo Sapiens

<400>  1021
gtcagtctgg ccggctccgt cctcccgtag gctccgctgt agctagcaat gtgacaccag       60

gacgcactcg ctctcgcgcg ctctcccagg ctcgttctcc ctcgccctct ctctctcaca      120

cacgcacgca cacacccacc tctcccataa acacacacac acacatgcac acccacaccc      180

acgcgcgccc gcaccgcccc acgcgcacac actcctgccc acgcccacgc agcgctccgg      240

gaagtccggt ccgggcgaga gcgcgaaagg ataccgagaa gccacccgcg gagagcgcag      300

cggcgccctg ggacgcggcg ctctcccggc gctgctgcct cggcttggtc tcggcctgcg      360

ggccgtcggc cggcgatggc cctggattat ctactactgc tcctcctggc atccgcagtg      420

gctgcgatgg aagaaacgtt aatggacacc agaacggcta ctgcagagct gggctggacg      480

gccaatcctg cgtccgggtg ggaagaagtc agtggctacg atgaaaacct gaacaccatc      540

cgcacctacc aggtgtgcaa tgtcttcgag cccaaccaga acaattggct gctcaccacc      600

ttcatcaacc ggcggggggc ccatcgcatc tacacagaga tgcgcttcac tgtgagagac      660

tgcagcagcc tccctaatgt cccaggatcc tgcaaggaga ccttcaactt gtattactat      720

gagactgact ctgtcattgc caccaagaag tcagccttct ggtctgaggc cccctacctc      780

aaagtagaca ccattgctgc agatgagagc ttctcccagg tggactttgg gggaaggctg      840

atgaaggtaa acacagaagt caggagcttt gggcctctta ctcggaatgg tttttacctc      900

gcttttcagg attatggagc ctgtatgtct cttctttctg tccgtgtctt cttcaaaaag      960

tgtcccagca ttgtgcaaaa ttttgcagtg tttccagaga ctatgacagg ggcagagagc     1020

acatctctgg tgattgctcg gggcacatgc atccccaacg cagaggaagt ggacgtgccc     1080

atcaaactct actgcaacgg ggatggggaa tggatggtgc ctattgggcg atgcacctgc     1140

aagcctggct atgagcctga gaacagcgtg gcatgcaagg cttgccctgc agggacattc     1200

aaggccagcc aggaagctga aggctgctcc cactgcccct ccaacagccg ctcccctgca     1260

gaggcgtctc ccatctgcac ctgtcggacc ggttattacc gagcggactt tgaccctcca     1320

gaagtggcat gcactagcgt cccatcaggt ccccgcaatg ttatctccat cgtcaatgag     1380

acgtccatca ttctggagtg gcaccctcca agggagacag gtgggcggga tgatgtgacc     1440

tacaacatca tctgcaaaaa gtgccgggca gaccgccgga gctgctcccg ctgtgacgac     1500

aatgtggagt ttgtgcccag gcagctgggc ctgacggagt gccgcgtctc catcagcagc     1560

ctgtgggccc acacccccta cacctttgac atccaggcca tcaatggagt ctccagcaag     1620

agtcccttcc ccccacagca cgtctctgtc aacatcacca caaaccaagc cgccccctcc     1680

accgttccca tcatgcacca agtcagtgcc actatgagga gcatcacctt gtcatggcca     1740

cagccggagc agcccaatgg catcatcctg gactatgaga tccggtacta tgagaaggaa     1800

cacaatgagt tcaactcctc catggccagg agtcagacca acacagcaag gattgatggg     1860

ctgcggcctg gcatggtata tgtggtacag gtgcgtgccc gcactgttgc tggctacggc     1920

aagttcagtg gcaagatgtg cttccagact ctgactgacg atgattacaa gtcagagctg     1980

agggagcagc tgcccctgat tgctggctcg gcagcggccg gggtcgtgtt cgttgtgtcc     2040

ttggtggcca tctctatcgt ctgtagcagg aaacgggctt atagcaaaga ggctgtgtac     2100

agcgataagc tccagcatta cagcacaggc cgaggctccc cagggatgaa gatctacatt     2160

gaccccttca cttacgagga tcccaacgaa gctgtccggg agtttgccaa ggagattgat     2220

gtatcttttg tgaaaattga agaggtcatc ggagcagggg agtttggaga agtgtacaag     2280

gggcgtttga aactgccagg caagagggaa atctacgtgg ccatcaagac cctgaaggca     2340

gggtactcgg agaagcagcg tcgggacttt ctgagtgagg cgagcatcat gggccagttc     2400

gaccatccta acatcattcg cctggagggt gtggtcacca agagtcggcc tgtcatgatc     2460

atcacagagt tcatggagaa tggtgcattg gattctttcc tcaggcaaaa tgacgggcag     2520

ttcaccgtga tccagcttgt gggtatgctc aggggcatcg ctgctggcat gaagtacctg     2580

gctgagatga attatgtgca tcgggacctg gctgctagga acattctggt caacagtaac     2640

ctggtgtgca aggtgtccga ctttggcctc tcccgctacc tccaggatga cacctcagat     2700

cccacctaca ccagctcctt gggagggaag atccctgtga gatggacagc tccagaggcc     2760

atcgcctacc gcaagttcac ttcagccagc gacgtttgga gctatgggat cgtcatgtgg     2820

gaagtcatgt catttggaga gagaccctat tgggatatgt ccaaccaaga tgtcatcaat     2880

gccatcgagc aggactaccg gctgccccca cccatggact gtccagctgc tctacaccag     2940

ctcatgctgg actgttggca gaaggaccgg aacagccggc cccggtttgc ggagattgtc     3000

aacaccctag ataagatgat ccggaacccg gcaagtctca agactgtggc aaccatcacc     3060

gccgtgcctt cccagcccct gctcgaccgc tccatcccag acttcacggc ctttaccacc     3120

gtggatgact ggctcagcgc catcaaaatg gtccagtaca gggacagctt cctcactgct     3180

ggcttcacct ccctccagct ggtcacccag atgacatcag aagacctcct gagaataggc     3240

atcaccttgg caggccatca gaagaagatc ctgaacagca ttcattctat gagggtccag     3300

ataagtcagt caccaacggc aatggcatga gaactcttgt ttcttgggga aggagaggag     3360

ggaaaaggac cagggtcaag ggggaccaga ggttgaccac tgtggaatgt actggagaga     3420

ctggcttctc agctgaggaa tgcatttcca tcagtgaaga atcaaccgga cctgttgcta     3480

gcaggcaatc tccatttctc agtgacagaa gcatgtttga gatgccgtgg gaaaccaaat     3540

atataataat aaaaatataa aaaggtgatg ttcaacagaa gtgaagacaa aacaatatgc     3600

atcaggagaa caagagtaaa cccagctccc actctcagtg ggctgcagtt gcccaaccac     3660

aggaagaaag ggaaggaggt agagggaaga aacagaagca gtgttccatt ttcttcctca     3720

ccaatgacat tcttttcttt tctcctttcg tactcctccc tgagagtccc ctcccttctc     3780

ccacactcgt ttccctttgc tcatgactcc tgtagggaag tttcttcaaa caaaacccag     3840

ctcctgagtc tccagatgtt gttctgtcag ttgccaaagg actttgctga ccactgcatg     3900

gggatccaac caattcaatt aatgtcttca tattgaagaa gagatgtacc ttcaattgaa     3960

aacctcgttt ttcttttgtt tgcattttct gcaaaaagga aaaagaaacc acaaattggg     4020

gaaaaaaaaa gaagaaaaac ctgtttccgt gtgcaaaagc acacatatgt atgtctgtgt     4080

tataaaatga ctgtgcttgt tcgtaacaga tgcaaacaag aaagaagaac tgggaagtct     4140

ttgtccctag gaaatccaaa ggggctggaa tatggtgttg gtttggcttt ctggttggcc     4200

caatcggcct attggctcaa tgggaagaga ggagagggag aaaaataaaa tgaaaggaaa     4260

aaaaaaagtt tgcaaattca gacaggaaac aggtgagtgg tttgaattgg atgcagtgtg     4320

ggccatcctg gaatgatact gactgattaa ttattcctga taacatctca agaaaaggag     4380

aaggaaagtg tttctggaga atgttctttc acatcactgg aatctgcaat tcaagaagtg     4440

acaagggaga attcttgctt tacctatgga ctggcttaag ccgtgtggca tccgaggaat     4500

gtttcaaatg tgtctgtgtt tctctttaca ttccttgttg tacctcattg ttcaattcac     4560

ttttgtaaat tccacctaac atttaattat tttaaatttc tccttttacc ttaatctcct     4620

tgctaatttt atctgtctaa ttaaaaagag cagaagcatg tctgggttta cgtaaaaaaa     4680

aaaaaaaaaa a                                                          4691


<210>  1022
<211>  984
<212>  PRT
<213>  Homo Sapiens

<400>  1022

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30          


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45              


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60                  


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80  


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95      


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110         


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125             


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140                 


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160 


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175     


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190         


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205             


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220                 


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255     


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270         


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285             


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300                 


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320 


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335     


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350         


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365             


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380                 


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400 


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415     


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430         


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445             


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460                 


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480 


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495     


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510         


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525             


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540                 


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560 


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575     


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590         


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605             


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620                 


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640 


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655     


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670         


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685             


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700                 


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720 


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735     


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750         


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765             


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780                 


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880 


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895     


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910         


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925             


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940                 


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960 


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975     


Ser Gln Ser Pro Thr Ala Met Ala 
            980                 


<210>  1023
<211>  1740
<212>  RNA
<213>  Homo Sapiens

<400>  1023
gacaaagaca acggcccaca gcgcacgacg cccgcggcca ccccaagggg gaacggccgc       60

acaggcgggg ggacccaccg cggccacaga cagggcgccc gccaccacac gcgcagccaa      120

aggagacccc ccccgaggcc cgcaggcaca cccgagggag gaagcccaaa ccaagaacgg      180

gccacgcccc gaccggcggc caggagggcc accggaggga cgcagaccgg gcaggaagcg      240

gcgcggaccc gcacgcgcgc gcccacgacg gcagacccca cgcacgccgc ggcgcagagg      300

gccacagccc ggcacggggg ggagcgcacc gacggagccg cggagcagga caaagacggc      360

gccaccgcca cgcaccgcgg cgagccgcgg ccacagcaag ggccagcggc gcgcgcacgg      420

cggggagacc ggcgaccggg ggcgggaccg cgcgacgacg ccgccgagaa cggggagcag      480

aggcgccaga ccggaggaac ggcgcggagc ggaagccgcg accgcgacgg gacgcggccg      540

cgaccgcgga ccaacggcca cagccacgca cccacgccgc gcacggggag aaccgagcag      600

gagcacgcgg cccccgggac caccgggagc ggaggcgaag cagccggaca ggcagcccac      660

ccaacaccac gggcggccag cccgaacgac ccagccgccc accagcaccc cccaacacga      720

cccgccccca gccacccagc acaagggcca gcacccccac ggggcccagc acagagcgca      780

gacaacagag cacaggacag cgaacccaga gcgggccgcc ggggcacgag ggaagcccaa      840

cccccaccac ccccacccag cccccccgcc acccccgccc ccaggcaccc aacgccccca      900

cccccaccag cacccacccc aagccccggg gaccacaggc agcgacacac agcagaccaa      960

gaacaaaccc gccacgggag acagaggccc caagaaggag ccgagcccgc gacggccacg     1020

acgggcacgg aggcaggacc cagccgcaag ccccgcgcca gcaagcagcc cagcacgggg     1080

gacacaccgg cagcgggccg cgccccggcg agacgcggcg cacgcccggg caggcgcacc     1140

gcgaggaggc ggaaccccgg gaaccacggc caacggcgcg ccgcggaccc caaggcgcca     1200

gggagcagca gcgccgccgc cgccgccgcc gccgccccgc ccgaggccgc gagcgccgcc     1260

gccggcccgc ccgcccccga gggcgcggcc cggcgcgggc agcgccgccc cccgcccacc     1320

ggcagcacca agccaacgga gcccgagggc gacaaccgga gcacggcgag aaaggcaggc     1380

aagagccgaa gccgacgcca cagagcaagg ggcgaccaca ggccaggcag caggcagccg     1440

gccccagccc gaggccgcgc cgcggcaccg cacgaccagc cggagcccca caccgccagc     1500

gcggggcagc cgcgccaacg gaagcggccg ggccgcccac acccgcgccg gggggcagcg     1560

gacgggaggc gccaccccac gcacgagagc agggccgccc aagcccgagg gaagcgccag     1620

ggagggggca agagcagcga agaggaggag gaggaggagc agaggggaaa gaggaggagg     1680

aggcccggcg gccagcagcc cgccggaggg ggaccccgcg gaagaagcgg aagaagagag     1740


<210>  1024
<211>  5115
<212>  DNA
<213>  Homo Sapiens

<400>  1024
aaagcgagct gaaccctgag gggagccgct gaccagcagc atggaggacc ccgccgcgcc       60

tgggaccggg ggcccgcccg caaatggcaa tggcaacggc ggcggcaaag ggaagcaggc      120

ggcgcccaag ggccgcgaag cgttccgaag ccagcggcgg gagtcagagg gctctgtgga      180

ctgtcccact ctggagtttg agtatggaga tgcagatggg catgcagccg agttgtcaga      240

attgtatagt tacactgaga acctggaatt caccaataac aggaggtgct ttgaagaaga      300

tttcaagact caagtgcagg gcaaggaatg gctggagttg gaagaagatg cccaaaaggc      360

ctatataatg ggactcttgg accggctaga ggtggtcagt agggaacggc ggctgaaggt      420

ggcccgggct gttctctacc tggcccaagg tacttttggg gaatgtgatt cagaggtcga      480

tgtgctacac tggtccaggt acaactgctt cctgctgtat cagatgggga ccttctccac      540

cttcctggag ctactccaca tggaaattga caacagccag gcctgtagca gtgcccttcg      600

gaaaccagct gtctccatag ctgatagcac agagctcagg gtgctgctga gtgttatgta      660

cctaatggtg gaaaatattc gcctggagcg agagacagac ccctgtgggt ggagaacagc      720

ccgggagacc ttccgcactg aattaagctt ctccatgcat aatgaggagc cttttgccct      780

tttactcttc tccatggtta ccaagttctg cagtggcctg gctcctcact tccccataaa      840

gaaggtcctg ctcctgctct ggaaggtggt catgtttacc ctcggtggat ttgagcatct      900

gcagactctc aaagtacaga agcgggcaga attgggcctg cctccactgg ctgaagacag      960

tatccaggtg gtgaagagca tgcgtgctgc ctccccgccc tcttacactc ttgacctggg     1020

agagtctcag ctggcacccc caccctccaa gctgcgaggc cgccgtggct ctcgaaggca     1080

actcctcact aagcaggaca gcctggacat ctacaatgaa agggatctct tcaagactga     1140

ggagcccgcc acagaggagg aagaggagtc tgctggtgat ggagaacgaa ccttggatgg     1200

agagctagac ctgctagagc aggaccctct ggtgccacct ccaccctcac aggcacccct     1260

ctctgctgag cgggtggctt ttcccaaggg cctgccctgg gccccaaagg tcagacagaa     1320

ggacattgag cacttcttgg agatgagcag gaacaagttc atcggattca ccctggggca     1380

ggacacagat acattggttg gattacccag gcccatccat gagagtgtga agaccctaaa     1440

gcagcacaag tatatctcca tcgcagatgt gcagatcaag aatgaagagg agctggagaa     1500

gtgccctatg tctttggggg aagaggtggt accagagacg ccatgtgaaa tcctctacca     1560

gggaatgctg tacagccttc cgcagtatat gatcgctctg cttaagattc tgctggctgc     1620

agctcccacc tctaaggcta agacagactc tatcaatatc ctggcagatg tcctacctga     1680

ggagatgccc atcactgttc tccagagcat gaagctgggc atcgatgtga acaggcacaa     1740

ggagattatt gtaaagagta tctctaccct gcttctgcta ctcctcaaac acttcaaact     1800

caaccatatc taccagtttg aatatgtatc gcaacatttg gtatttgcca actgcatccc     1860

cttgatcctg aagttcttca atcaaaatat cttgtcatac atcactgcca aaaacagcat     1920

ctcagtcctg gattatcctt gctgtaccat ccaggatttg ccggagctta ctactgaaag     1980

tctggaagct ggagacaaca gccagttctg ctggaggaac ctcttttcct gcatcaacct     2040

cctgaggctg ctcaataaac tgaccaaatg gaaacattcc cggaccatga tgctggtagt     2100

gtttaaatcg gcaccaatct taaagcgggc cctcaaggtc aaacaggcca tgctgcaact     2160

ttatgtccta aagctactaa agttacagac caagtacctg gggcgccaat ggaggaaaag     2220

caacatgaaa accatgtcag ccatttacca gaaagtgcgt caccgcatga acgatgactg     2280

ggcttacggg aatgacatcg atgccagacc atgggacttc caagcagaag aatgtacctt     2340

gagggccaac attgaggctt ttaacagccg tcgctatgac agaccccagg actctgagtt     2400

ttcacctgtg gataactgct tgcagagcgt actggggcag aggttggatc tgcctgaaga     2460

tttccactat tcatatgagc tctggctcga gagagaggtg ttttcacagc ccatctgttg     2520

ggaggagctg ctccagaatc actgactaag ttcttgtcaa caagcatcaa tagatagagg     2580

tcagctccaa taaactgtgc tctgcctacc ctgtccatac aggcgctgtt accagttcag     2640

ggctcttctg ggggctcttg ggcctaaaga tggtgcaagg gtgggatcct gaatcacaat     2700

aaaatgatca acttgccctg gggtcagttg ggtgcccagt tggccttgga aatcttttgg     2760

tggatcaatt ctagacaagc tctttggtag gaccttttcc tgctttagtc ttggctacaa     2820

ccaggctaga ctttgctggc tctaaaagag gaaatttgtt atggcatttg acccatggca     2880

ttcatcacag atagtgggag gtacaagtca taaaataggg agaaagtttt cttcttgctc     2940

acactggatt cctaggactt atcagagatt tggaaaaacc aactttgaaa ttaagtttgc     3000

attttaaatt tcaaatttgg aagcctcttt ctgaaatcat tagctctaag attattttag     3060

agcacctgca ccttctttgt gaaggatgat gatttactat tccctcaata ctgcatgtta     3120

tcgaaaagtg tgttgtgtaa agtgtttttt tcctcattct gtaagagatc tatattcaat     3180

gtgaaaatta tttccttgtg tactctgtat agggcatgga atgctctgcc atttttaaag     3240

agccacaacc aatatgaaat aattaggtcc tctctaagga tgtttcatgt ttttcttaaa     3300

tgactccagt cttcaaatgg ctgagcatac tgcagaaaat tatccttttc atctaattca     3360

ttttttaaat gacaagttaa ctacaggagg ctttatttat tcagatggta tgtccacttg     3420

tggtcgtgat caatatattt ttctaattga aaagtaaaag catcacagct taccattttt     3480

ctttttctgc agtgttgatt aatgattttt ttcccgttta ttgctagcag tttcaaagtg     3540

tcatgtggag atttagcaat actgtctcta cttaaaagta ttgcacattt cattgaaaat     3600

gtgagagttg atataccagc ctctttatat ttctctttta cagcagaatc acatacttct     3660

caagataaac aaggttttta aaaaagtttc tgatttagtt aggatcatat gctttttttt     3720

tttttttttt tttttttttt ttttttgaga cagagtttcg ctcttgttgc ccaagctgga     3780

gtgcaatggc acgatctcgg ctcactgcaa cctccgcctc ccgggttcaa gcgattctcc     3840

tgcctcagcc tcccaaggag ctgggattac aggcacgcac caccatgcct ggctaatttt     3900

ttgtattttt agtagaaaca gggtttcacc atgttagcca ggctgacctc aaactcctga     3960

cctcaggtga tccgcccgcc tccacctccc agggtgctgg gattacaggt gtgagccacc     4020

atgcccagcc tcttcaagct tttttactat acatgttgcc cctctccccc aacttaggca     4080

ctactgaatt ttttatgatg gcaccaggtc actttatgct gggtgatata gtcaaaattt     4140

gcttatttac tctgcccctc gtcaaccaca gtatcatttc aaggacatga ataaaatact     4200

tgacagtatc caaaggagct ataccaaaat ctaacaagta aattttggat tttgcctctt     4260

tgtgctttaa agtaccagga tttctgtctc tatggatagg tcttggagaa tgttaagtaa     4320

tggatgaaac tttttaaaat aatttgtaaa ttttacctaa gtaggacagt agtccttact     4380

gcaatcaaaa taatttactg agcacaactc ctgtaaatta atctacagtc aggctagtat     4440

gattttaata tgatttgagt aaaaagataa ttttcaagga aagagtaatc atccatcaat     4500

ttattataaa gccagatagt attcaattta tgtcaagaac aaagaaattg cccttttaaa     4560

agcatgtacg tgaatgcttt ttgaggcaca gaagtatgct aagctttaac attttgtatt     4620

tatttacaac ccttttctaa gggaaggtta cttctcagtg cagatggaga aactgaagca     4680

ctaaggataa atgattagtt tccaatcaca tcattttttt ccacagactt gctgggacta     4740

gctttcaggt attgacagcc agccccatat attaaggtaa ccaggttgaa tcttccaatt     4800

tgagaaccca tgtatgggtt gcagtgagcc gagatcatgc cactgcactc catcctgggc     4860

aacaagaacg aaactccgtc tcaaaaacaa agaaggatat aataaagtta atatataaac     4920

catgtatgtg gttaggaata aattcaaatt caccagtctc caatggtgat tacttttact     4980

acatagaaaa acattttagt gacttacaga ggatttttat ttgtgaatat ttcagtaaag     5040

tttgtgttga ttgttgataa cactgttcat ctactgaagc actttaataa aaataaaatg     5100

agctggaatt agaaa                                                      5115


<210>  1025
<211>  834
<212>  PRT
<213>  Homo Sapiens

<400>  1025

Met Glu Asp Pro Ala Ala Pro Gly Thr Gly Gly Pro Pro Ala Asn Gly 
1               5                   10                  15      


Asn Gly Asn Gly Gly Gly Lys Gly Lys Gln Ala Ala Pro Lys Gly Arg 
            20                  25                  30          


Glu Ala Phe Arg Ser Gln Arg Arg Glu Ser Glu Gly Ser Val Asp Cys 
        35                  40                  45              


Pro Thr Leu Glu Phe Glu Tyr Gly Asp Ala Asp Gly His Ala Ala Glu 
    50                  55                  60                  


Leu Ser Glu Leu Tyr Ser Tyr Thr Glu Asn Leu Glu Phe Thr Asn Asn 
65                  70                  75                  80  


Arg Arg Cys Phe Glu Glu Asp Phe Lys Thr Gln Val Gln Gly Lys Glu 
                85                  90                  95      


Trp Leu Glu Leu Glu Glu Asp Ala Gln Lys Ala Tyr Ile Met Gly Leu 
            100                 105                 110         


Leu Asp Arg Leu Glu Val Val Ser Arg Glu Arg Arg Leu Lys Val Ala 
        115                 120                 125             


Arg Ala Val Leu Tyr Leu Ala Gln Gly Thr Phe Gly Glu Cys Asp Ser 
    130                 135                 140                 


Glu Val Asp Val Leu His Trp Ser Arg Tyr Asn Cys Phe Leu Leu Tyr 
145                 150                 155                 160 


Gln Met Gly Thr Phe Ser Thr Phe Leu Glu Leu Leu His Met Glu Ile 
                165                 170                 175     


Asp Asn Ser Gln Ala Cys Ser Ser Ala Leu Arg Lys Pro Ala Val Ser 
            180                 185                 190         


Ile Ala Asp Ser Thr Glu Leu Arg Val Leu Leu Ser Val Met Tyr Leu 
        195                 200                 205             


Met Val Glu Asn Ile Arg Leu Glu Arg Glu Thr Asp Pro Cys Gly Trp 
    210                 215                 220                 


Arg Thr Ala Arg Glu Thr Phe Arg Thr Glu Leu Ser Phe Ser Met His 
225                 230                 235                 240 


Asn Glu Glu Pro Phe Ala Leu Leu Leu Phe Ser Met Val Thr Lys Phe 
                245                 250                 255     


Cys Ser Gly Leu Ala Pro His Phe Pro Ile Lys Lys Val Leu Leu Leu 
            260                 265                 270         


Leu Trp Lys Val Val Met Phe Thr Leu Gly Gly Phe Glu His Leu Gln 
        275                 280                 285             


Thr Leu Lys Val Gln Lys Arg Ala Glu Leu Gly Leu Pro Pro Leu Ala 
    290                 295                 300                 


Glu Asp Ser Ile Gln Val Val Lys Ser Met Arg Ala Ala Ser Pro Pro 
305                 310                 315                 320 


Ser Tyr Thr Leu Asp Leu Gly Glu Ser Gln Leu Ala Pro Pro Pro Ser 
                325                 330                 335     


Lys Leu Arg Gly Arg Arg Gly Ser Arg Arg Gln Leu Leu Thr Lys Gln 
            340                 345                 350         


Asp Ser Leu Asp Ile Tyr Asn Glu Arg Asp Leu Phe Lys Thr Glu Glu 
        355                 360                 365             


Pro Ala Thr Glu Glu Glu Glu Glu Ser Ala Gly Asp Gly Glu Arg Thr 
    370                 375                 380                 


Leu Asp Gly Glu Leu Asp Leu Leu Glu Gln Asp Pro Leu Val Pro Pro 
385                 390                 395                 400 


Pro Pro Ser Gln Ala Pro Leu Ser Ala Glu Arg Val Ala Phe Pro Lys 
                405                 410                 415     


Gly Leu Pro Trp Ala Pro Lys Val Arg Gln Lys Asp Ile Glu His Phe 
            420                 425                 430         


Leu Glu Met Ser Arg Asn Lys Phe Ile Gly Phe Thr Leu Gly Gln Asp 
        435                 440                 445             


Thr Asp Thr Leu Val Gly Leu Pro Arg Pro Ile His Glu Ser Val Lys 
    450                 455                 460                 


Thr Leu Lys Gln His Lys Tyr Ile Ser Ile Ala Asp Val Gln Ile Lys 
465                 470                 475                 480 


Asn Glu Glu Glu Leu Glu Lys Cys Pro Met Ser Leu Gly Glu Glu Val 
                485                 490                 495     


Val Pro Glu Thr Pro Cys Glu Ile Leu Tyr Gln Gly Met Leu Tyr Ser 
            500                 505                 510         


Leu Pro Gln Tyr Met Ile Ala Leu Leu Lys Ile Leu Leu Ala Ala Ala 
        515                 520                 525             


Pro Thr Ser Lys Ala Lys Thr Asp Ser Ile Asn Ile Leu Ala Asp Val 
    530                 535                 540                 


Leu Pro Glu Glu Met Pro Ile Thr Val Leu Gln Ser Met Lys Leu Gly 
545                 550                 555                 560 


Ile Asp Val Asn Arg His Lys Glu Ile Ile Val Lys Ser Ile Ser Thr 
                565                 570                 575     


Leu Leu Leu Leu Leu Leu Lys His Phe Lys Leu Asn His Ile Tyr Gln 
            580                 585                 590         


Phe Glu Tyr Val Ser Gln His Leu Val Phe Ala Asn Cys Ile Pro Leu 
        595                 600                 605             


Ile Leu Lys Phe Phe Asn Gln Asn Ile Leu Ser Tyr Ile Thr Ala Lys 
    610                 615                 620                 


Asn Ser Ile Ser Val Leu Asp Tyr Pro Cys Cys Thr Ile Gln Asp Leu 
625                 630                 635                 640 


Pro Glu Leu Thr Thr Glu Ser Leu Glu Ala Gly Asp Asn Ser Gln Phe 
                645                 650                 655     


Cys Trp Arg Asn Leu Phe Ser Cys Ile Asn Leu Leu Arg Leu Leu Asn 
            660                 665                 670         


Lys Leu Thr Lys Trp Lys His Ser Arg Thr Met Met Leu Val Val Phe 
        675                 680                 685             


Lys Ser Ala Pro Ile Leu Lys Arg Ala Leu Lys Val Lys Gln Ala Met 
    690                 695                 700                 


Leu Gln Leu Tyr Val Leu Lys Leu Leu Lys Leu Gln Thr Lys Tyr Leu 
705                 710                 715                 720 


Gly Arg Gln Trp Arg Lys Ser Asn Met Lys Thr Met Ser Ala Ile Tyr 
                725                 730                 735     


Gln Lys Val Arg His Arg Met Asn Asp Asp Trp Ala Tyr Gly Asn Asp 
            740                 745                 750         


Ile Asp Ala Arg Pro Trp Asp Phe Gln Ala Glu Glu Cys Thr Leu Arg 
        755                 760                 765             


Ala Asn Ile Glu Ala Phe Asn Ser Arg Arg Tyr Asp Arg Pro Gln Asp 
    770                 775                 780                 


Ser Glu Phe Ser Pro Val Asp Asn Cys Leu Gln Ser Val Leu Gly Gln 
785                 790                 795                 800 


Arg Leu Asp Leu Pro Glu Asp Phe His Tyr Ser Tyr Glu Leu Trp Leu 
                805                 810                 815     


Glu Arg Glu Val Phe Ser Gln Pro Ile Cys Trp Glu Glu Leu Leu Gln 
            820                 825                 830         


Asn His 
        


<210>  1026
<211>  4063
<212>  DNA
<213>  Homo Sapiens

<400>  1026
gttcttcttt ctacctttct aagattccac catgttgctt gtttagttca accagtgctg       60

atagggacac gtttgcactt gtctctcagt gaacattcgc aagagatttt ctaggcctcc      120

aggcagaagc cgctgctgac ggggagagtc tgctggagga agtcacatgg cagatgccag      180

aggaccagcc tgggagaggc tttctagcaa ccaggacacc tgccgcagtg ccacgctttc      240

tccaggaaac aaggacagct gcacgggtgc ccacacgaga gtcggcgacc agcctcggcg      300

gtggggttcc tgcaacgcgt gttcctgctg gggttctcct ttctgctgtt ccgagctaca      360

gtgcggatca tgctccccat acgtggagtc cagggacagc acagcccggg gactgcccag      420

ccagccagga agtctggctt tcagagaact gggaagacca tcttccactt tatcccatct      480

gggagactgt aaacatggat tccactgtct cggacagtga gacgattccc agtcttttcc      540

tgttcctcct ctaggtatgt agctgctatc agcttccaga aacgctggaa ggaagggcgt      600

tgctttggca ggacacgtgg ggagatgggc tgggagggga gatcccggag gtaaggaggg      660

gaggctttcc tctccccaca ctgggaactc agtttctagc cccaggttcc tggttgtgtc      720

cggcatccca ggagcatgag tgggaagctg ctgcatccac ctgccgtgtg cagtcgggga      780

ccagctgcag agcgcactat gcatccttta gactctgcag gctcaagtga aaacccagct      840

ctgccactgc tctctggatg accttgccac ctccctctcc tcctttgaaa agtgtgggaa      900

atgctgcttt tcatcaagtc caagtcacca tgtattgtgg cttaaacggc agtgttattt      960

tctttctcag tgacacataa catactgctg cgttttttaa cagatgctgt cttggacgca     1020

gtgaagtctg ccgatggctg tttcagagcc gttaggatgg tgaagtgaga caatgtgaat     1080

ggagtgtttt gtgaggctca gtgctgcata aatgctagcc attatctaat agcaagaatt     1140

ccttgaaatg tttctttctc tcaaatttat gaaaagatta gaaaatagtt ctaaaaatta     1200

aaaatgcttc tggtcggagc ggcttacatg atggcagtga aagtgtgcag cttcatgggt     1260

cccactgcgt gcacttggca tggagagaac gaaatgtgga ggccagcgat accaagaaca     1320

cccctgtgag ccgcgctggg tgcagccccc acggccggcg ggcagtgaca ccgcagtttc     1380

ctctcctgcc ggcgtccacg cttcctgtgc ccaggtgctg gaagctcagt cttcatgtcc     1440

ccttctcagt tatgtgtctg tggggctggg acagggaagg aagtcagtga agctggttgg     1500

atcttccaag ggatgctctg tgtgcaaggc tcggggacaa ggatggctgg gggagtcaga     1560

ctgtcagtga agctgagggg cggatggagc ctcaccacgc ctgagtccct gttttccagc     1620

tgcagatgct gaccctccag agctttgttt accagcccct gtgactgcga tctggagtca     1680

gccaggcgtt cctccttgtc cggtagattt tattaagtgc tcaatgtgtg ccaagccaaa     1740

tgtccgtttg acttactgca tgtccgagaa gcgatgccgt tgaaggaatt tcctccccaa     1800

gcctgaagga attgaacacc aggaatgact ggaaccctgg agagagagaa ctggatttct     1860

ggaggaaaat cactcgtttt aaggaagcag catcctggac ccttgaggcc ctggaggaag     1920

cgggcagcac agctcggagg cgggtgtggc tggaggacgg ccgtcgcacc tgcgaaattc     1980

tgtctgtggt acgtggttcc ttcctggctc tgggaaccac ctggatactt gcattcttcc     2040

cttttccttt ctattctctt tcaagtcacc ctccttgaga cagccctcca gtccaggcca     2100

aatctcagcc tgcccttggt ccgctgtggt tgggcctgca cccaagccat gagcacacgc     2160

agcaattgtg gcagcagaag cttcctctgg gctcagactc aggctgatgc tgcgtcagga     2220

ctgccgcggt ctcggctggg cttcctggga ctcggtggtt gtgggctgat tgtaaagcac     2280

ggaatgactc ttagaaactg ggcgtcattc tttgtggttt tccaagcttg gtctctgatg     2340

atactccagg tcttaggaga catgctgaat atttattatg cttacattca agcaacatta     2400

acccttaagg ttgatgtagc tccccgtctt tttttcccag aaggaggagc actgaaggaa     2460

cacttttcca gtatggattc tttccagctc cgagaagctg gaggcacacg gatccctcgg     2520

ccagctctca tctatggacg tgctgtagtc acaaggactg tgactaaggc tcagtccctg     2580

aagagtgcct tggcatgggc tgctttaggc tgtaaacacc cagttttatc cactttatgt     2640

gaagaaagcc aacaaggggc atggagtgag ttccgcaggt tttagtggct gcggaggctg     2700

gtgctcagtg gggatgatgg agggaaggcg cctccctctg cgggccccga ggtctgtgcg     2760

ggaatcagct ctgcagttgt gtccaggggc agccgtagac cacacacggc aggctcacag     2820

ctctgttcca tgagaacttt atacacaaaa gcagacgggc tggcttggcc tctggatcat     2880

aatctgctga cccctggggc aacgttggct gcagcggaga tggctgctcc ccggtggggt     2940

gtgtgctcag cccgcagccc ccgccctccg gactccgttc gcctctgctc tcagctttgc     3000

acctcgtcat tgtcttctaa ttgtgcatcc ctggactgcg tgacctacaa ggctctcagc     3060

acaacaagac tctatgattc tgtctattgg aacaaaaagc cagtgaggca agtgtatcat     3120

cctgttgatg aattcacaga attaactctg ggagttgggg acagtttgta ttcttcttcc     3180

agacactctc tgtttctgct ggatggaaag gttctgctac ttgtcctgtg gtcaggccca     3240

gctgatggaa tggaatggaa gtgactcagc cccttactgg cagaaacttt aaaagccgca     3300

caacattcct gcaccctccc ctctgccatg agcctggcag tgctcaggat gggaaaatta     3360

tttcacctgg gcctgaggat acaggagcta ctcccagcgt gcagtggaag agaagcatgg     3420

gcaagtaatt aaactttgtg ttttcaagcc acagaggttt tttgaggttg tttgctacca     3480

tgctttgtcc ctacaaacac agtcatggag aaggccagtg gcagagcctg agccgttcgt     3540

gcatctgttc accagcatcc agaataacaa tagatttttg aaacattcct gagaaaattc     3600

tgggagttgc ataccggcca gtcttattcc ctaaagttgt tccttctaaa gggtgggatg     3660

accaaaaatt tcagaaaagc aaaccaccgc tgaaaggcaa cgttatttct gttggcagaa     3720

ggcggcctga gcaatctaga ttttccacgg ttcgccaact agtttttaag gaaatatggc     3780

tgtgagagga ataaaacata attcctacct ttaaggaact cagagaagtg aattaaagga     3840

agtcacagat caggcaacca accacacaaa gtttctaaga gcaaactgtt caggtcggca     3900

agtcactctt atccactgtt ttgccttctg aggtttcagt tactctcagt cagtcatggt     3960

ccaaaaacat taaatgaaaa attccagaaa taaacaattc acacgtttta aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaacaaa aaaaaaaaaa aaa                       4063


<210>  1027
<211>  5722
<212>  DNA
<213>  Homo Sapiens

<400>  1027
atttttaact tcgcaacact tggactattt ctgttgaagt tttctctcct ttccctgcct       60

tcccaacaga acgctgtcct ctactgcagc tgatgcaacc cagccacctc ccggcaatcc      120

gcttacttgc aatcaagggt tcaggtgcaa gcagatgctg actcagcctg ttccattaag      180

agctaagaag caagaagaaa ttggggcgcc atggggaaag cccgcagatc cccgccaggg      240

caccacaggc attgtgaggg atgcttcaac cgccactgcc acattcctgt ggaacccaac      300

acctcctgcc tggtaataag ctgccacctg ctctgtggtg ccaccttcca catgtgcaaa      360

gaggcagagc accagctcct ctgcccttta gagcaggttc cgtgcctcaa ctccgaatat      420

ggctgccctc tgtccatgtc ccgccacaaa ctggccaagc acctgcaggt gtgccccgcc      480

agcgtggtct gctgctccat ggagtggaac cgctggccaa atgtggactc tgaaaccacc      540

cttcatgaaa acatcatgaa agagaccccc agtgaggagt gtttggacac agccctggcc      600

ctgcaggatc agaaggtcct cttcagatcc ttgaaaatgg tggaactttt cccagaaact      660

agagaggcta ctgaggagga accaactatg aatggtgaaa ccagtgtgga ggaaatggga      720

ggagcagtgg gtggagtgga tatcggtttg gtaccacatg gtctgtcagc aactaatggg      780

gagatggcag agctaagtca agaagaacgg gaggtgctag ccaaaaccaa agaagggatg      840

gacctggtca agtttggcca gtgggaaaat attttcagca aagagcacgc agcctctgct      900

ttaacaaatt catcagcgag ctgtgagagc aagaacaaga atgactccga gaaagaacag      960

atttccagtg gccataacat ggtagaagga gagggcgctc ccaaaaagaa agaaccacag     1020

gaaaatcaga agcagcagga cgttcgtaca gccatggaaa ccacagggct tgccccttgg     1080

caggatggtg ttctggaaag actgaaaaca gctgtggatg caaaggacta taacatgtat     1140

ctagtgcaca atgggcggat gctgatacac tttggtcaga tgcctgcttg tacacccaag     1200

gagagagact ttgtttatgg caagctggag gctcaggaag ttaagactgt ttacaccttc     1260

aaagttcctg tgagctactg tggaaagcga gctcgacttg gagatgccat gttgagttgt     1320

aagccaagtg aacacaaggc agtggatact tcagatttgg ggatcactgt ggaggacctg     1380

cccaaatcag atctcatcaa gaccaccctc cagtgtgctt tggaaagaga actcaaaggc     1440

cacgtcatct ctgaatccag aagcattgat ggactgttca tggattttgc cacacaaaca     1500

tacaactttg agccagaaca gttttcctct gggacagtgc tggctgacct aaccgctgcc     1560

accccagggg gactccacgt ggagctccac agcgagtgtg tgaccaggag acacaacaaa     1620

agcagctctg ccttcacttt cacttgcaac aaattcttca ggagggatga gttccccctg     1680

cacttcaaga atgtccacac agacattcag tcatgtctca atggctggtt ccagcatcga     1740

tgccccctcg cctacttggg atgtacattt gttcaaaacc atttccgtcc cccagggcaa     1800

aaggcaaaag taatctatag ccaggagctc aagacctttg ccattaagcc ggaggttgct     1860

ccagagctga gcgagggaag gaagaacaac catcttttgg gtcatggagg aaaaagccag     1920

aattctttaa ccagcctgcc cctggagatt ttgaagtaca ttgctgggtt cttggacagc     1980

gtcagcctgg cccagctctc ccaggtgtct gtgctgatga ggaatatctg tgccactttg     2040

ttacaagaga gaggaatggt ccttttgcaa tggaagaaaa agaggtattc ccatggaggc     2100

acctcctgga gagtccacag agagatctgg cagttcagca gcctcttctc caaaatcaag     2160

agctgggagt ttaatgaagt cacctccatg tctgagcacc tgaagtcctg tcctttcaac     2220

attgtagagc acaaaactga cccgattctt ttgactagca tgtgtcagcc ccgtgagcag     2280

gcccgagaga gcttagtctc cacctttaga atcagaccac gaggaagata cgtctcctaa     2340

aaattcagat gccactcgat gcacccttct tggatttctt ctcggagttc ctgaagtagg     2400

acagagtgtg tggttttgag gactcccttc tgtaaactgc ctatttgctt atcggggtgt     2460

attggaacac gcaatgtcct tcgaaacctc aacacgaggc ctaagaattt cctaagccat     2520

gtcttgtacc atagtgccac attgatgact tgtttccttt tttcttttct tttcttttct     2580

tttttctttc tttctaaaat agattggtct gagaagaaaa taagtaattt gaggccattt     2640

ggaagatggg cccaatttct taagtgatga gagagcacga aattccataa ccagtacagg     2700

cctgtgcttt tacatgggct ttttagttca caaagcactt tcaaatttat gggacaggaa     2760

atgcaggatg ggactcccca gggaacgcag ggtgaaggga acaaagctgg aggctctgga     2820

gctgggtctg ttttgacggt caagtccagg gctcattttg gttattctac tgcctctagg     2880

ccagggtagt cctaacacag cctgacatag gagagcccct ggctgagcat ggcagccttg     2940

aagacaccac aggccaaaac atgaggggca gaaatgggat cacagagtct gttgctagaa     3000

tcttggcaac atacagcagg aaagccttga taaatcggga gtccaaagga gacaccatat     3060

ttatggagaa cattaggaca aaaagtcacc aacttacttt gtaacatttt aataatgact     3120

taagggtcaa gatttttttc ttctgaaaat tatgttctga gttaggcaga acatagccat     3180

ggccctgggc caccctgtgc tatctgaaat gacctcaata cactaatgcc aacctcagcg     3240

tcatgccaga atgcacaggg cagcccaggg agatcacacc tttggcaaag tccagacaag     3300

gcccactgca gttcctatgg cgccagtcac cagctcctag acagcacttg ggtaccccat     3360

tggggtcttg gagaggaaga catgtgaaca taacggctcc ctgaaattgc tcctacccat     3420

ccatatttct ggtcatgctt tcagtctgac aaaaatggat gatactgctg tttttggtaa     3480

caaacagtga atattcataa gaacaaaagt aaaagaaaaa aagacacagt agaaactggc     3540

atcccctaaa gcagggcttc ttagccttgg aactattgac atttttaaat ggataattct     3600

tttttttttt ttctaggtgg ggaggggatg gagttcactc ttgttgccca ggctggagcg     3660

caatgacatg atctcggctc accgcaacct ccgcctcctg ggttcaagcg attctcctgc     3720

ctcagcctcc cgagtagctg ggattactcg cctggctaat tttgtatttt tagtagagac     3780

gggctttctc catgttgttc aggctggtct caaactcccg acctcaggtg actcgcccgc     3840

cttggccttc caaagtgctg ggtttacagg tgtgagccac tgcgccctgc ctgaactgga     3900

taattctttg ttgcaaggga ctgttctgtg tactacagga tacttggcag catccttggc     3960

ctatccatta aatgtcagta gcacccccac agtggcaaca atcaaaaatg tcaccagaca     4020

ttgctaaata ttggggagca aaatggctcc ccgttgaaaa tccctaaagg atgtcatact     4080

agtgacaata agttaggata tgcttatttt ttagtacagc aaaatcttat cgcacatagc     4140

tatccacaat agttatgatt taatgcagct ctttatttat gaaataggtt ttagacatgt     4200

ggtgatttta agttgggaac cagaaggaaa tgattcgttt ggtatggctt catgtccttc     4260

agccaccccc aagaatgtat cctttcagct ctctttggtt atacctgaag ccaggagcgt     4320

tgagttatta gccttgtgtt tatattcctc tcactgtaat tggtgtcatt ttcccagcag     4380

tcctagcagt cctcaagcaa gtgggaaatc ggaaaagaaa aggacaggca ttgtagggaa     4440

gcagaggata aagaatttag ccaacaaaag aaacaatcta gtcaatctgg gtgcttttat     4500

ttcctgggtt ctctctaaac atggctcaga gctggtgtag atgaagtagg tgaaacctct     4560

gaaaagagtc tagaaggcag tagagcaagt cccagaccag aaacatgctc atcttttcat     4620

cgtaatgtgc cactcggtac tatttggtaa tgtcactcta tttttcctaa tcccatcctt     4680

tggtttgtat ttcatatttg tatataaggc accattttct aaaaatatga ctagggtgtg     4740

acctaaggtt ttattctgtg aagatgagta actggaaaga agctaacact gcagtgggaa     4800

ggaaggaaga gagttgtcca ggtggtagtt cgacgtgttt tgaatctagt ccttcctaca     4860

tggaggataa aagctcctaa agtccactct gggtttgtga ttttaataga aatagaaagg     4920

gaaactatag accaatggag atgaaaatca ggggctatcg acagatggag gagaaataag     4980

gtgctacata gagaaaggaa gagggcagaa ggctttccct tcccaaactg ggtgagctgg     5040

ggaagccttg gttcaggaga gtggcactgc ccacaactgc tttgtgggtt gtgcacttcc     5100

agccgcactc tccccctcca gttgctgcct tcagagccgt actgaagcac gagcttcaat     5160

aagacaagca cacttcatag tgagagggca gcggtaccaa agcctttcag agagactatg     5220

gattagacag aaatgatttg tgagaggaag ctggagtgaa cagcatgaac agcgagtgtt     5280

acctgacaga ggcaagacag ctagaagtgg cttcagattt agaaacagct gaggggagca     5340

aagacggact gtgtacacag ggagggagga tgtctatggg cagagccctt ggtgagtatc     5400

atcaccaaga aaggcagtcc agagtagaga tcagccgaat atggaggctg aggtctgtag     5460

aactgggcca gagaggacct tactgcctta gtagcataag ggtctggaaa agaagtttct     5520

atctcacaac aaaggaaaaa gtgaaaagca aggtggaact tgaagatacg tcacgaaaat     5580

cactataaaa gtctgattta tgtgtgatgt caaatcaaac tgaaatgaag aatgagattg     5640

agtatatctg tggtgactga cctctgtata ctagaaacct caacatctct agaagaggaa     5700

ataaaagctg ctttgcactc tg                                              5722


<210>  1028
<211>  709
<212>  PRT
<213>  Homo Sapiens

<400>  1028

Met Gly Lys Ala Arg Arg Ser Pro Pro Gly His His Arg His Cys Glu 
1               5                   10                  15      


Gly Cys Phe Asn Arg His Cys His Ile Pro Val Glu Pro Asn Thr Ser 
            20                  25                  30          


Cys Leu Val Ile Ser Cys His Leu Leu Cys Gly Ala Thr Phe His Met 
        35                  40                  45              


Cys Lys Glu Ala Glu His Gln Leu Leu Cys Pro Leu Glu Gln Val Pro 
    50                  55                  60                  


Cys Leu Asn Ser Glu Tyr Gly Cys Pro Leu Ser Met Ser Arg His Lys 
65                  70                  75                  80  


Leu Ala Lys His Leu Gln Val Cys Pro Ala Ser Val Val Cys Cys Ser 
                85                  90                  95      


Met Glu Trp Asn Arg Trp Pro Asn Val Asp Ser Glu Thr Thr Leu His 
            100                 105                 110         


Glu Asn Ile Met Lys Glu Thr Pro Ser Glu Glu Cys Leu Asp Thr Ala 
        115                 120                 125             


Leu Ala Leu Gln Asp Gln Lys Val Leu Phe Arg Ser Leu Lys Met Val 
    130                 135                 140                 


Glu Leu Phe Pro Glu Thr Arg Glu Ala Thr Glu Glu Glu Pro Thr Met 
145                 150                 155                 160 


Asn Gly Glu Thr Ser Val Glu Glu Met Gly Gly Ala Val Gly Gly Val 
                165                 170                 175     


Asp Ile Gly Leu Val Pro His Gly Leu Ser Ala Thr Asn Gly Glu Met 
            180                 185                 190         


Ala Glu Leu Ser Gln Glu Glu Arg Glu Val Leu Ala Lys Thr Lys Glu 
        195                 200                 205             


Gly Met Asp Leu Val Lys Phe Gly Gln Trp Glu Asn Ile Phe Ser Lys 
    210                 215                 220                 


Glu His Ala Ala Ser Ala Leu Thr Asn Ser Ser Ala Ser Cys Glu Ser 
225                 230                 235                 240 


Lys Asn Lys Asn Asp Ser Glu Lys Glu Gln Ile Ser Ser Gly His Asn 
                245                 250                 255     


Met Val Glu Gly Glu Gly Ala Pro Lys Lys Lys Glu Pro Gln Glu Asn 
            260                 265                 270         


Gln Lys Gln Gln Asp Val Arg Thr Ala Met Glu Thr Thr Gly Leu Ala 
        275                 280                 285             


Pro Trp Gln Asp Gly Val Leu Glu Arg Leu Lys Thr Ala Val Asp Ala 
    290                 295                 300                 


Lys Asp Tyr Asn Met Tyr Leu Val His Asn Gly Arg Met Leu Ile His 
305                 310                 315                 320 


Phe Gly Gln Met Pro Ala Cys Thr Pro Lys Glu Arg Asp Phe Val Tyr 
                325                 330                 335     


Gly Lys Leu Glu Ala Gln Glu Val Lys Thr Val Tyr Thr Phe Lys Val 
            340                 345                 350         


Pro Val Ser Tyr Cys Gly Lys Arg Ala Arg Leu Gly Asp Ala Met Leu 
        355                 360                 365             


Ser Cys Lys Pro Ser Glu His Lys Ala Val Asp Thr Ser Asp Leu Gly 
    370                 375                 380                 


Ile Thr Val Glu Asp Leu Pro Lys Ser Asp Leu Ile Lys Thr Thr Leu 
385                 390                 395                 400 


Gln Cys Ala Leu Glu Arg Glu Leu Lys Gly His Val Ile Ser Glu Ser 
                405                 410                 415     


Arg Ser Ile Asp Gly Leu Phe Met Asp Phe Ala Thr Gln Thr Tyr Asn 
            420                 425                 430         


Phe Glu Pro Glu Gln Phe Ser Ser Gly Thr Val Leu Ala Asp Leu Thr 
        435                 440                 445             


Ala Ala Thr Pro Gly Gly Leu His Val Glu Leu His Ser Glu Cys Val 
    450                 455                 460                 


Thr Arg Arg His Asn Lys Ser Ser Ser Ala Phe Thr Phe Thr Cys Asn 
465                 470                 475                 480 


Lys Phe Phe Arg Arg Asp Glu Phe Pro Leu His Phe Lys Asn Val His 
                485                 490                 495     


Thr Asp Ile Gln Ser Cys Leu Asn Gly Trp Phe Gln His Arg Cys Pro 
            500                 505                 510         


Leu Ala Tyr Leu Gly Cys Thr Phe Val Gln Asn His Phe Arg Pro Pro 
        515                 520                 525             


Gly Gln Lys Ala Lys Val Ile Tyr Ser Gln Glu Leu Lys Thr Phe Ala 
    530                 535                 540                 


Ile Lys Pro Glu Val Ala Pro Glu Leu Ser Glu Gly Arg Lys Asn Asn 
545                 550                 555                 560 


His Leu Leu Gly His Gly Gly Lys Ser Gln Asn Ser Leu Thr Ser Leu 
                565                 570                 575     


Pro Leu Glu Ile Leu Lys Tyr Ile Ala Gly Phe Leu Asp Ser Val Ser 
            580                 585                 590         


Leu Ala Gln Leu Ser Gln Val Ser Val Leu Met Arg Asn Ile Cys Ala 
        595                 600                 605             


Thr Leu Leu Gln Glu Arg Gly Met Val Leu Leu Gln Trp Lys Lys Lys 
    610                 615                 620                 


Arg Tyr Ser His Gly Gly Thr Ser Trp Arg Val His Arg Glu Ile Trp 
625                 630                 635                 640 


Gln Phe Ser Ser Leu Phe Ser Lys Ile Lys Ser Trp Glu Phe Asn Glu 
                645                 650                 655     


Val Thr Ser Met Ser Glu His Leu Lys Ser Cys Pro Phe Asn Ile Val 
            660                 665                 670         


Glu His Lys Thr Asp Pro Ile Leu Leu Thr Ser Met Cys Gln Pro Arg 
        675                 680                 685             


Glu Gln Ala Arg Glu Ser Leu Val Ser Thr Phe Arg Ile Arg Pro Arg 
    690                 695                 700                 


Gly Arg Tyr Val Ser 
705                 


<210>  1029
<211>  2429
<212>  DNA
<213>  Homo Sapiens

<400>  1029
ctcttttcta agcttgtctc ttaaaaccca ctggacgttg gcacagtgct gggatgacta       60

tggagaccca aatgtctcag aatgtatgtc ccagaaacct gtggctgctt caaccattga      120

cagttttgct gctgctggct tctgcagaca gtcaagctgc agctccccca aaggctgtgc      180

tgaaacttga gcccccgtgg atcaacgtgc tccaggagga ctctgtgact ctgacatgcc      240

agggggctcg cagccctgag agcgactcca ttcagtggtt ccacaatggg aatctcattc      300

ccacccacac gcagcccagc tacaggttca aggccaacaa caatgacagc ggggagtaca      360

cgtgccagac tggccagacc agcctcagcg accctgtgca tctgactgtg ctttccgaat      420

ggctggtgct ccagacccct cacctggagt tccaggaggg agaaaccatc atgctgaggt      480

gccacagctg gaaggacaag cctctggtca aggtcacatt cttccagaat ggaaaatccc      540

agaaattctc ccatttggat cccaccttct ccatcccaca agcaaaccac agtcacagtg      600

gtgattacca ctgcacagga aacataggct acacgctgtt ctcatccaag cctgtgacca      660

tcactgtcca agtgcccagc atgggcagct cttcaccaat ggggatcatt gtggctgtgg      720

tcattgcgac tgctgtagca gccattgttg ctgctgtagt ggccttgatc tactgcagga      780

aaaagcggat ttcagccaat tccactgatc ctgtgaaggc tgcccaattt gagccacctg      840

gacgtcaaat gattgccatc agaaagagac aacttgaaga aaccaacaat gactatgaaa      900

cagctgacgg cggctacatg actctgaacc ccagggcacc tactgacgat gataaaaaca      960

tctacctgac tcttcctccc aacgaccatg tcaacagtaa taactaaaga gtaacgttat     1020

gccatgtggt catactctca gcttgctgag tggatgacaa aaagagggga attgttaaag     1080

gaaaatttaa atggagactg gaaaaatcct gagcaaacaa aaccacctgg cccttagaaa     1140

tagctttaac tttgcttaaa ctacaaacac aagcaaaact tcacggggtc atactacata     1200

caagcataag caaaacttaa cttggatcat ttctggtaaa tgcttatgtt agaaataaga     1260

caaccccagc caatcacaag cagcctacta acatataatt aggtgactag ggactttcta     1320

agaagatacc tacccccaaa aaacaattat gtaattgaaa accaaccgat tgcctttatt     1380

ttgcttccac attttcccaa taaatacttg cctgtgacat tttgccactg gaacactaaa     1440

cttcatgaat tgcgcctcag atttttcctt taacatcttt tttttttttg acagagtctc     1500

aatctgttac ccaggctgga gtgcagtggt gctatcttgg ctcactgcaa acccgcctcc     1560

caggtttaag cgattctcat gcctcagcct cccagtagct gggattagag gcatgtgcca     1620

tcatacccag ctaatttttg tattttttat tttttttttt tagtagagac agggtttcgc     1680

aatgttggcc aggccgatct cgaacttctg gcctctagcg atctgcccgc ctcggcctcc     1740

caaagtgctg ggatgaccag catcagcccc aatgtccagc ctctttaaca tcttctttcc     1800

tatgccctct ctgtggatcc ctactgctgg tttctgcctt ctccatgctg agaacaaaat     1860

cacctattca ctgcttatgc agtcggaagc tccagaagaa caaagagccc aattaccaga     1920

accacattaa gtctccattg ttttgccttg ggatttgaga agagaattag agaggtgagg     1980

atctggtatt tcctggacta aattcccctt ggggaagacg aagggatgct gcagttccaa     2040

aagagaagga ctcttccaga gtcatctacc tgagtcccaa agctccctgt cctgaaagcc     2100

acagacaata tggtcccaaa tgactgactg caccttctgt gcctcagccg ttcttgacat     2160

caagaatctt ctgttccaca tccacacagc caatacaatt agtcaaacca ctgttattaa     2220

cagatgtagc aacatgagaa acgcttatgt tacaggttac atgagagcaa tcatgtaagt     2280

ctatatgact tcagaaatgt taaaatagac taacctctaa caacaaatta aaagtgattg     2340

tttcaaggtg atgcaattat tgatgaccta ttttattttt ctataatgat catatattac     2400

ctttgtaata aaacattata accaaaaca                                       2429


<210>  1030
<211>  317
<212>  PRT
<213>  Homo Sapiens

<400>  1030

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  1031
<211>  2174
<212>  DNA
<213>  Homo Sapiens

<400>  1031
agaacatttc tttttcactt cccctttcag actccagaat ttgtttgccc tctagggtag       60

aatccgccaa gctttgagag aaggctgtga ctgctgtgct ctgggcgcca gctcgctcca      120

gggagtgatg ggaatcctgt cattcttacc tgtccttgcc actgagagtg actgggctga      180

ctgcaagtcc ccccagcctt ggggtcatat gcttctgtgg acagctgtgc tattcctggc      240

tcctgttgct gggacacctg cagctccccc aaaggctgtg ctgaaactcg agccccagtg      300

gatcaacgtg ctccaggagg actctgtgac tctgacatgc cgggggactc acagccctga      360

gagcgactcc attcagtggt tccacaatgg gaatctcatt cccacccaca cgcagcccag      420

ctacaggttc aaggccaaca acaatgacag cggggagtac acgtgccaga ctggccagac      480

cagcctcagc gaccctgtgc atctgactgt gctttctgag tggctggtgc tccagacccc      540

tcacctggag ttccaggagg gagaaaccat cgtgctgagg tgccacagct ggaaggacaa      600

gcctctggtc aaggtcacat tcttccagaa tggaaaatcc aagaaatttt cccgttcgga      660

tcccaacttc tccatcccac aagcaaacca cagtcacagt ggtgattacc actgcacagg      720

aaacataggc tacacgctgt actcatccaa gcctgtgacc atcactgtcc aagctcccag      780

ctcttcaccg atggggatca ttgtggctgt ggtcactggg attgctgtag cggccattgt      840

tgctgctgta gtggccttga tctactgcag gaaaaagcgg atttcagctc tcccaggata      900

ccctgagtgc agggaaatgg gagagaccct ccctgagaaa ccagccaatc ccactaatcc      960

tgatgaggct gacaaagttg gggctgagaa cacaatcacc tattcacttc tcatgcaccc     1020

ggatgctctg gaagagcctg atgaccagaa ccgtatttag tctccattgt cttgcattgg     1080

gatttgagaa gaaaatcaga gagggaagat ctggtatttc ctggcctaaa ttccccttgg     1140

ggaggacagg gagatgctgc agttccaaaa gagaaggttt cttccagagt catctacctg     1200

agtcctgaag ctccctgtcc tgaaagccac agacaatatg gtcccaaata accgactgca     1260

ccttctgtgc ttcagctctt cttgacatca aggctcttcc gttccacatc cacacagcca     1320

atccaattaa tcaaaccact gttattaaca gataatagca acttgggaaa tgcttatgtt     1380

acaggttacg tgagaacaat catgtaaatc tatatgattt cagaaatgtt aaaatagact     1440

aacctctacc agcacattaa aagtgattgt ttctgggtga taaaattatt gatgattttt     1500

attttcttta tttttctata aagatcatat attactttta taataaaaca ttataaaaac     1560

aacattctgt ttaccttttc aaggctgtat tggttggagt gtagactgaa ctgcctgggg     1620

tctgtttctc ttcagtgatg agactcttag gaaggcagga atggatagga tagggggagg     1680

agaggagaga tggggattta gaatgtagag tgagtgcccc ttttcttaaa actgaataca     1740

gtcacgcacc acataatgat gtttagttca acaacagact gcatatatga tggtgatccc     1800

ataaaattat aataccatat ttctattgta ccttttctat tcctatgttt agatatatga     1860

gtacttacca ttgtgttaca attgcctaaa gtattcagta cagtagcatg ctgtacaggt     1920

ttgtagccta ggggcaatag gctatacgct acagcctagg tgtgtagtag gccacaccat     1980

ttaggtttgt ataagtacct gctatgatgt tcacacaaca aaattgcctg catttctcaa     2040

aatgtatccc catatttcaa caatgcatga ctgtactctt ctgccaatga ccttgtattc     2100

ttgtttccat gtcttcttct ctttcctcct atggcaaata aaacactgtt ttgcaacaca     2160

aaaaaaaaaa aaaa                                                       2174


<210>  1032
<211>  310
<212>  PRT
<213>  Homo Sapiens

<400>  1032

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  1033
<211>  1510
<212>  DNA
<213>  Homo Sapiens

<400>  1033
agactccaga atttgtttgc cctctagggt agaatccgcc aagctttgag agaaggctgt       60

gactgctgtg ctctgggcgc cagctcgctc cagggagtga tgggaatcct gtcattctta      120

cctgtccttg ccactgagag tgactgggct gactgcaagt ccccccagcc ttggggtcat      180

atgcttctgt ggacagctgt gctattcctg gctcctgttg ctgggacacc tgcagctccc      240

ccaaaggctg tgctgaaact cgagccccag tggatcaacg tgctccaaga ggactctgtg      300

actctgacat gccgggggac tcacagccct gagagcgact ccattccgtg gttccacaat      360

gggaatctca ttcccaccca cacgcagccc agctacaggt tcaaggccaa caacaatgac      420

agcggggagt acacgtgcca gactggccag accagcctca gcgaccctgt gcatctgact      480

gtgctttctg agtggctggt gctccagacc cctcacctgg agttccagga gggagaaacc      540

atcgtgctga ggtgccacag ctggaaggac aagcctctgg tcaaggtcac attcttccag      600

aatggaaaat ccaagaaatt ttcccgttcg gatcccaact tctccatccc acaagcaaac      660

cacagtcaca gtggtgatta ccactgcaca ggaaacatag gctacacgct gtactcatcc      720

aagcctgtga ccatcactgt ccaagctccc agctcttcac cgatggggat cattgtggct      780

gtggtcactg ggattgctgt agcggccatt gttgctgctg tagtggcctt gatctactgc      840

aggaaaaagc ggatttcagc caattccact gatcctgtga aggctgccca atttgagcca      900

cctggacgtc aaatgattgc catcagaaag agacaacctg aagaaaccaa caatgactat      960

gaaacagctg acggcggcta catgactctg aaccccaggg cacctactga cgatgataaa     1020

aacatctacc tgactcttcc tcccaacgac catgtcaaca gtaataacta aagagtaacg     1080

ttatgccatg tggtcacact ctcagcttgc tgagtggatg acaaaaagag gggaattgtt     1140

aaaggaaaat ttaaatggag actggaaaaa ttcctgagca aacaaaacca cctggccctt     1200

agaaatagct ttaactttgc ttaaactaca aacacaagca aaacttcacg gggtcatact     1260

acatacaagc ataagcaaaa cttaacttgg atgatttctg gtaaatgctt atgttagaaa     1320

taagacaacc ccagccaatc acaagcagcc tactaacata taattaggtg actagggact     1380

ttctaagaag atacctaccc ccaaaaaaca attatgtaat tgaaaaccca tcgattgcct     1440

ttattttgct tccacatttt cccaataaat acttgcctgt gacattttgc cactggaaca     1500

ctaaacttca                                                            1510


<210>  1034
<211>  323
<212>  PRT
<213>  Homo Sapiens

<400>  1034

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Pro Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser 
                245                 250                 255     


Thr Asp Pro Val Lys Ala Ala Gln Phe Glu Pro Pro Gly Arg Gln Met 
            260                 265                 270         


Ile Ala Ile Arg Lys Arg Gln Pro Glu Glu Thr Asn Asn Asp Tyr Glu 
        275                 280                 285             


Thr Ala Asp Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala Pro Thr Asp 
    290                 295                 300                 


Asp Asp Lys Asn Ile Tyr Leu Thr Leu Pro Pro Asn Asp His Val Asn 
305                 310                 315                 320 


Ser Asn Asn 
            


<210>  1035
<211>  4260
<212>  DNA
<213>  Homo Sapiens

<400>  1035
atggaaggca ctcattgtac cctccaattg cataagccca ttacggaact ctgctacatc       60

agcttctgtc ttccaaaggg ggaagtcaga ggattttcat acaagggcac tgtaactcta      120

gacagatcca ataaaggttt tcataactgc taccaagtca gggaggagtc agacatcatc      180

agcctcagcc aggagccgga cgaacatcca ggcgacatat ttttcaagca gactcccacg      240

aaagacattc taactgagct gtacaaactc acaacagaga gggagagact gctaaccaat      300

ctcctgagct cagaccacat cctggggatc acgatgggga accaggaggg gaagctgcaa      360

gagctgtccg tgagcctggc ccccgaggat gactgtttcc agagtgctgg tgactggcag      420

ggagagctcc ccgtgggccc tctcaataag aggagcaccc acgggaacaa aaagcctcgg      480

aggtctagtg gaaggagaga gagctttggg gcccttccac agaagaggac caaaagaaaa      540

gggcgtggag gccgagaatc agctcctctg atgggcaagg acaagatctg ttccagccac      600

tcccttcctc tttctagaac aaggcctaac ctttgggtac tagaggagaa aggaaatctg      660

ctcccgaatg gggcacttgc ctgctccctg cagaggagag agagctgccc cccagatatt      720

cccaagacgc cagacacaga ccttggcttt gggagctttg agacggcttt caaggacact      780

gggcttggaa gagaagtgct gccccctgac tgcagctcca cagaggcagg aggggatggc      840

attcggaggc cgccgagcgg gctggagcat cagcaaacag gtttgtctga aagtcaccag      900

gaccctgaga agcatccaga ggcagaaaag gatgagatgg agaagccggc taagcggact      960

tgcaagcaga aacctgtctc caaagtggtg gccaaagttc aggacctgtc ctcccaggta     1020

caaagagtag ttaaaacgca ttctaagggt aaggagacga ttgccattcg cccagcagcc     1080

cacgctgagt ttgtacccaa agccgacttg ctcaccctcc cgggagctga ggctggggct     1140

catggctcca ggcggcaggg caaggagcgg caaggggata ggtcatcgca gtcgccagcc     1200

ggggaaacag cctccatttc tagtgtgtcg gccagtgccg agggggccgt gaacaaggtc     1260

cccctgaagg tgatagagag tgagaagtta gatgaagccc ctgaggggaa aagactgggc     1320

ttccctgtcc acacgagtgt ccctcacact cgcccagaaa cgagaaacaa gaggagagcc     1380

gggttgcccc ttggtggcca caagtccttg tttctggatc tgccccacaa agtaggtcct     1440

gactcctcac aacccagagg tgataagaag aagccatccc caccagcacc ggcagctctt     1500

ggcaaggtgt ttaataattc agcctcgcag tccagcacac acaaacagac gtcacctgtt     1560

ccctcgcctc tgtctccaag gctccccagc cctcagcagc atcacaggat cctccggctc     1620

cctgcattgc ctggtgagag ggaagctgct cttaatgact ctccttgtag aaagagccgt     1680

gtcttctctg ggtgcgtctc tgctgacacc ttggagccac catcctctgc aaaggtcacg     1740

gagaccaaag gagccagccc ggccttcctc agagcaggcc aacctcggtt ggtgcctggg     1800

gaaactttgg aaaagagctt ggggccaggg aagaccacag ctgagcccca gcaccagtca     1860

cctccaggta tctcctctga gggctttccc tgggacggct tcaatgagca gacacctaaa     1920

gaccttccca acagagatgg aggcgcgtgg gttctgggct acagagcggg accagcctgt     1980

ccatttttgc ttcatgagga aagggagaag tcaaacagga gcgaattgta cttggatctc     2040

catcctgacc acagcctgac tgagcaggat gacaggactc ctggcagact tcaagctgtc     2100

tggccacccc caaagacaaa agacacagaa gaaaaagtgg gactgaagta cactgaagca     2160

gaataccaag ctgctatttt acacttgaag agggagcaca aagaagaaat tgaaaacctg     2220

caggcacagt ttgaacttcg ggcatttcat atccggggcg agcatgcaat gataacagcg     2280

agactagaag aaaccattga aaatctgaaa cacgagctag aacacagatg gcgagggggt     2340

tgtgaagaga ggaaagatgt gtgcatttcc accgatgatg actgccctcc aaagaccttc     2400

agaaatgtgt gcgtccagac agacagagag accttcctca agccctgtga aagtgaaagc     2460

aagacaacca gaagtaatca attagtaccc aaaaagctga atatctcctc tttaagccag     2520

ctctcacccc caaatgacca caaagacatc catgcagcac tccagccaat ggagggcatg     2580

gcatcaaatc agcagaaggc attgcctccg cctcccgcat ccatccctcc ccctccgccc     2640

ctcccctcag gacttggatc tttgtctccc gcacctccaa tgccacctgt gagtgctggg     2700

ccaccgctac cacctccgcc tcctccaccg ccacctctac ctccaccttc aagtgctgga     2760

cctccaccac ccccaccccc acccccactt cctaactccc ctgccccacc caaccctgga     2820

gggcctcctc ctgctccacc acccccagga cttgcacccc cacctccccc tggactcttc     2880

tttggacttg gctcttcttc cagtcaatgt cctcgaaaac cagccatcga gcccagttgt     2940

cccatgaagc ctttatattg gactaggata caaataagtg ataggagcca aaatgctaca     3000

ccaaccttat gggactcctt agaagaacct gacattcggg accccagtga atttgagtat     3060

ttattctcca aagacacaac tcaacagaag aaaaaacctc tgtcagagac ttatgagaag     3120

aaaaacaagg tcaaaaagat catcaaattg ttggatggaa aacgatctca aactgtggga     3180

atcttgatat ctagtttaca tttagaaatg aaggatatcc aacaggccat tttcaatgtg     3240

gatgactccg tggttgatct ggagaccctg gcagccttat atgaaaacag agcccaagag     3300

gatgagctgg ttaaaataag aaagtattac gagacatcca aagaagaaga actgaagctg     3360

ctggataaac ctgagcaatt tttacatgag ttagcccaga ttcctaattt tgctgaacgt     3420

gcccagtgca taatcttcag atctgtcttt tctgagggta tcacctcctt gcacagaaag     3480

gtagagatca tcacgcgagc ttctaaggac ttgctgcacg tgaagagcgt gaaggatatt     3540

ttagctctca tcttggcttt tggaaattat atgaatggag gaaataggac tcggggacaa     3600

gccgatggat atagcttaga aattctgccc aaactcaagg atgtcaaaag tcgggataat     3660

gggattaatc tggtggacta cgttgttaag tattacctgc gttactatga tcaggaagct     3720

ggaacagaaa agagtgtttt ccccttgccg gaaccacagg atttctttct ggcctcccaa     3780

gtcaagtttg aagacctcat aaaagatttg agaaaactga agaggcaact agaagcaagt     3840

gagaaacaga tggtggtggt gtgcaaggag tccccaaagg agtatctcca gcctttcaag     3900

gacaaactag aggagttctt ccaaaaagcc aaaaaagagc ataagatgga agaaagtcac     3960

ttggagaatg cacagaaaag ttttgaaaca acagtacgat attttgggat gaagccaaag     4020

tctggtgaga aggagatcac acccagctac gtgtttatgg tgtggtatga gttctgcagt     4080

gacttcaaga caatttggaa acgggagagt aaaaacatat ctaaagaaag attgaaaatg     4140

gctcaggaat cagtcagcaa gttgacttca gagaagaaag tggagacaaa gaaaatcaat     4200

cccactgcta gcctgaaaga aagactgcgt cagaaggaag ccagtgtgac cactaactaa     4260


<210>  1036
<211>  1419
<212>  PRT
<213>  Homo Sapiens

<400>  1036

Met Glu Gly Thr His Cys Thr Leu Gln Leu His Lys Pro Ile Thr Glu 
1               5                   10                  15      


Leu Cys Tyr Ile Ser Phe Cys Leu Pro Lys Gly Glu Val Arg Gly Phe 
            20                  25                  30          


Ser Tyr Lys Gly Thr Val Thr Leu Asp Arg Ser Asn Lys Gly Phe His 
        35                  40                  45              


Asn Cys Tyr Gln Val Arg Glu Glu Ser Asp Ile Ile Ser Leu Ser Gln 
    50                  55                  60                  


Glu Pro Asp Glu His Pro Gly Asp Ile Phe Phe Lys Gln Thr Pro Thr 
65                  70                  75                  80  


Lys Asp Ile Leu Thr Glu Leu Tyr Lys Leu Thr Thr Glu Arg Glu Arg 
                85                  90                  95      


Leu Leu Thr Asn Leu Leu Ser Ser Asp His Ile Leu Gly Ile Thr Met 
            100                 105                 110         


Gly Asn Gln Glu Gly Lys Leu Gln Glu Leu Ser Val Ser Leu Ala Pro 
        115                 120                 125             


Glu Asp Asp Cys Phe Gln Ser Ala Gly Asp Trp Gln Gly Glu Leu Pro 
    130                 135                 140                 


Val Gly Pro Leu Asn Lys Arg Ser Thr His Gly Asn Lys Lys Pro Arg 
145                 150                 155                 160 


Arg Ser Ser Gly Arg Arg Glu Ser Phe Gly Ala Leu Pro Gln Lys Arg 
                165                 170                 175     


Thr Lys Arg Lys Gly Arg Gly Gly Arg Glu Ser Ala Pro Leu Met Gly 
            180                 185                 190         


Lys Asp Lys Ile Cys Ser Ser His Ser Leu Pro Leu Ser Arg Thr Arg 
        195                 200                 205             


Pro Asn Leu Trp Val Leu Glu Glu Lys Gly Asn Leu Leu Pro Asn Gly 
    210                 215                 220                 


Ala Leu Ala Cys Ser Leu Gln Arg Arg Glu Ser Cys Pro Pro Asp Ile 
225                 230                 235                 240 


Pro Lys Thr Pro Asp Thr Asp Leu Gly Phe Gly Ser Phe Glu Thr Ala 
                245                 250                 255     


Phe Lys Asp Thr Gly Leu Gly Arg Glu Val Leu Pro Pro Asp Cys Ser 
            260                 265                 270         


Ser Thr Glu Ala Gly Gly Asp Gly Ile Arg Arg Pro Pro Ser Gly Leu 
        275                 280                 285             


Glu His Gln Gln Thr Gly Leu Ser Glu Ser His Gln Asp Pro Glu Lys 
    290                 295                 300                 


His Pro Glu Ala Glu Lys Asp Glu Met Glu Lys Pro Ala Lys Arg Thr 
305                 310                 315                 320 


Cys Lys Gln Lys Pro Val Ser Lys Val Val Ala Lys Val Gln Asp Leu 
                325                 330                 335     


Ser Ser Gln Val Gln Arg Val Val Lys Thr His Ser Lys Gly Lys Glu 
            340                 345                 350         


Thr Ile Ala Ile Arg Pro Ala Ala His Ala Glu Phe Val Pro Lys Ala 
        355                 360                 365             


Asp Leu Leu Thr Leu Pro Gly Ala Glu Ala Gly Ala His Gly Ser Arg 
    370                 375                 380                 


Arg Gln Gly Lys Glu Arg Gln Gly Asp Arg Ser Ser Gln Ser Pro Ala 
385                 390                 395                 400 


Gly Glu Thr Ala Ser Ile Ser Ser Val Ser Ala Ser Ala Glu Gly Ala 
                405                 410                 415     


Val Asn Lys Val Pro Leu Lys Val Ile Glu Ser Glu Lys Leu Asp Glu 
            420                 425                 430         


Ala Pro Glu Gly Lys Arg Leu Gly Phe Pro Val His Thr Ser Val Pro 
        435                 440                 445             


His Thr Arg Pro Glu Thr Arg Asn Lys Arg Arg Ala Gly Leu Pro Leu 
    450                 455                 460                 


Gly Gly His Lys Ser Leu Phe Leu Asp Leu Pro His Lys Val Gly Pro 
465                 470                 475                 480 


Asp Ser Ser Gln Pro Arg Gly Asp Lys Lys Lys Pro Ser Pro Pro Ala 
                485                 490                 495     


Pro Ala Ala Leu Gly Lys Val Phe Asn Asn Ser Ala Ser Gln Ser Ser 
            500                 505                 510         


Thr His Lys Gln Thr Ser Pro Val Pro Ser Pro Leu Ser Pro Arg Leu 
        515                 520                 525             


Pro Ser Pro Gln Gln His His Arg Ile Leu Arg Leu Pro Ala Leu Pro 
    530                 535                 540                 


Gly Glu Arg Glu Ala Ala Leu Asn Asp Ser Pro Cys Arg Lys Ser Arg 
545                 550                 555                 560 


Val Phe Ser Gly Cys Val Ser Ala Asp Thr Leu Glu Pro Pro Ser Ser 
                565                 570                 575     


Ala Lys Val Thr Glu Thr Lys Gly Ala Ser Pro Ala Phe Leu Arg Ala 
            580                 585                 590         


Gly Gln Pro Arg Leu Val Pro Gly Glu Thr Leu Glu Lys Ser Leu Gly 
        595                 600                 605             


Pro Gly Lys Thr Thr Ala Glu Pro Gln His Gln Ser Pro Pro Gly Ile 
    610                 615                 620                 


Ser Ser Glu Gly Phe Pro Trp Asp Gly Phe Asn Glu Gln Thr Pro Lys 
625                 630                 635                 640 


Asp Leu Pro Asn Arg Asp Gly Gly Ala Trp Val Leu Gly Tyr Arg Ala 
                645                 650                 655     


Gly Pro Ala Cys Pro Phe Leu Leu His Glu Glu Arg Glu Lys Ser Asn 
            660                 665                 670         


Arg Ser Glu Leu Tyr Leu Asp Leu His Pro Asp His Ser Leu Thr Glu 
        675                 680                 685             


Gln Asp Asp Arg Thr Pro Gly Arg Leu Gln Ala Val Trp Pro Pro Pro 
    690                 695                 700                 


Lys Thr Lys Asp Thr Glu Glu Lys Val Gly Leu Lys Tyr Thr Glu Ala 
705                 710                 715                 720 


Glu Tyr Gln Ala Ala Ile Leu His Leu Lys Arg Glu His Lys Glu Glu 
                725                 730                 735     


Ile Glu Asn Leu Gln Ala Gln Phe Glu Leu Arg Ala Phe His Ile Arg 
            740                 745                 750         


Gly Glu His Ala Met Ile Thr Ala Arg Leu Glu Glu Thr Ile Glu Asn 
        755                 760                 765             


Leu Lys His Glu Leu Glu His Arg Trp Arg Gly Gly Cys Glu Glu Arg 
    770                 775                 780                 


Lys Asp Val Cys Ile Ser Thr Asp Asp Asp Cys Pro Pro Lys Thr Phe 
785                 790                 795                 800 


Arg Asn Val Cys Val Gln Thr Asp Arg Glu Thr Phe Leu Lys Pro Cys 
                805                 810                 815     


Glu Ser Glu Ser Lys Thr Thr Arg Ser Asn Gln Leu Val Pro Lys Lys 
            820                 825                 830         


Leu Asn Ile Ser Ser Leu Ser Gln Leu Ser Pro Pro Asn Asp His Lys 
        835                 840                 845             


Asp Ile His Ala Ala Leu Gln Pro Met Glu Gly Met Ala Ser Asn Gln 
    850                 855                 860                 


Gln Lys Ala Leu Pro Pro Pro Pro Ala Ser Ile Pro Pro Pro Pro Pro 
865                 870                 875                 880 


Leu Pro Ser Gly Leu Gly Ser Leu Ser Pro Ala Pro Pro Met Pro Pro 
                885                 890                 895     


Val Ser Ala Gly Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            900                 905                 910         


Leu Pro Pro Pro Ser Ser Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Leu Pro Asn Ser Pro Ala Pro Pro Asn Pro Gly Gly Pro Pro Pro 
    930                 935                 940                 


Ala Pro Pro Pro Pro Gly Leu Ala Pro Pro Pro Pro Pro Gly Leu Phe 
945                 950                 955                 960 


Phe Gly Leu Gly Ser Ser Ser Ser Gln Cys Pro Arg Lys Pro Ala Ile 
                965                 970                 975     


Glu Pro Ser Cys Pro Met Lys Pro Leu Tyr Trp Thr Arg Ile Gln Ile 
            980                 985                 990         


Ser Asp Arg Ser Gln Asn Ala Thr  Pro Thr Leu Trp Asp  Ser Leu Glu 
        995                 1000                 1005             


Glu Pro  Asp Ile Arg Asp Pro  Ser Glu Phe Glu Tyr  Leu Phe Ser 
    1010                 1015                 1020             


Lys Asp  Thr Thr Gln Gln Lys  Lys Lys Pro Leu Ser  Glu Thr Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Asn Lys Val Lys  Lys Ile Ile Lys Leu  Leu Asp Gly 
    1040                 1045                 1050             


Lys Arg  Ser Gln Thr Val Gly  Ile Leu Ile Ser Ser  Leu His Leu 
    1055                 1060                 1065             


Glu Met  Lys Asp Ile Gln Gln  Ala Ile Phe Asn Val  Asp Asp Ser 
    1070                 1075                 1080             


Val Val  Asp Leu Glu Thr Leu  Ala Ala Leu Tyr Glu  Asn Arg Ala 
    1085                 1090                 1095             


Gln Glu  Asp Glu Leu Val Lys  Ile Arg Lys Tyr Tyr  Glu Thr Ser 
    1100                 1105                 1110             


Lys Glu  Glu Glu Leu Lys Leu  Leu Asp Lys Pro Glu  Gln Phe Leu 
    1115                 1120                 1125             


His Glu  Leu Ala Gln Ile Pro  Asn Phe Ala Glu Arg  Ala Gln Cys 
    1130                 1135                 1140             


Ile Ile  Phe Arg Ser Val Phe  Ser Glu Gly Ile Thr  Ser Leu His 
    1145                 1150                 1155             


Arg Lys  Val Glu Ile Ile Thr  Arg Ala Ser Lys Asp  Leu Leu His 
    1160                 1165                 1170             


Val Lys  Ser Val Lys Asp Ile  Leu Ala Leu Ile Leu  Ala Phe Gly 
    1175                 1180                 1185             


Asn Tyr  Met Asn Gly Gly Asn  Arg Thr Arg Gly Gln  Ala Asp Gly 
    1190                 1195                 1200             


Tyr Ser  Leu Glu Ile Leu Pro  Lys Leu Lys Asp Val  Lys Ser Arg 
    1205                 1210                 1215             


Asp Asn  Gly Ile Asn Leu Val  Asp Tyr Val Val Lys  Tyr Tyr Leu 
    1220                 1225                 1230             


Arg Tyr  Tyr Asp Gln Glu Ala  Gly Thr Glu Lys Ser  Val Phe Pro 
    1235                 1240                 1245             


Leu Pro  Glu Pro Gln Asp Phe  Phe Leu Ala Ser Gln  Val Lys Phe 
    1250                 1255                 1260             


Glu Asp  Leu Ile Lys Asp Leu  Arg Lys Leu Lys Arg  Gln Leu Glu 
    1265                 1270                 1275             


Ala Ser  Glu Lys Gln Met Val  Val Val Cys Lys Glu  Ser Pro Lys 
    1280                 1285                 1290             


Glu Tyr  Leu Gln Pro Phe Lys  Asp Lys Leu Glu Glu  Phe Phe Gln 
    1295                 1300                 1305             


Lys Ala  Lys Lys Glu His Lys  Met Glu Glu Ser His  Leu Glu Asn 
    1310                 1315                 1320             


Ala Gln  Lys Ser Phe Glu Thr  Thr Val Arg Tyr Phe  Gly Met Lys 
    1325                 1330                 1335             


Pro Lys  Ser Gly Glu Lys Glu  Ile Thr Pro Ser Tyr  Val Phe Met 
    1340                 1345                 1350             


Val Trp  Tyr Glu Phe Cys Ser  Asp Phe Lys Thr Ile  Trp Lys Arg 
    1355                 1360                 1365             


Glu Ser  Lys Asn Ile Ser Lys  Glu Arg Leu Lys Met  Ala Gln Glu 
    1370                 1375                 1380             


Ser Val  Ser Lys Leu Thr Ser  Glu Lys Lys Val Glu  Thr Lys Lys 
    1385                 1390                 1395             


Ile Asn  Pro Thr Ala Ser Leu  Lys Glu Arg Leu Arg  Gln Lys Glu 
    1400                 1405                 1410             


Ala Ser  Val Thr Thr Asn 
    1415                 


<210>  1037
<211>  2134
<212>  DNA
<213>  Homo Sapiens

<400>  1037
acccaagcca gcactggctc atactgattc attttgatct ctgctaatac cagagtcctg       60

cgtggcagag ccattggcac cagaaattac aagagaacat ggccaagcga gttgccattg      120

tgggagctgg ggtcagcggc ctggcctcca tcaagtgctg tctggaagaa ggactggagc      180

ccacctgctt tgagaggagc gatgaccttg gggggctgtg gagattcacc gaacatgttg      240

aagaaggcag agccagtctc tacaagtctg tggtttccaa cagctgcaag gagatgtctt      300

gttactcaga ctttccattc ccagaagatt atccaaacta tgtgccaaat tctcaattcc      360

tggaatatct caaaatgtat gcaaaccact ttgaccttct gaaacacatt caattcaaga      420

ccaaagtctg cagtgtaaca aaatgctcag attctgctgt ctctggccaa tgggaggtgg      480

tcactatgca tgaagagaag caagagtcag ccatctttga tgctgtcatg gtctgcactg      540

gctttcttac taatccttat ttgccactgg attcctttcc aggtattaat gcctttaaag      600

gccagtactt tcatagccgg caatataagc atccagatat atttaaggac aagagagtcc      660

ttgtgattgg aatgggaaat tctggcacag acattgctgt ggaggccagc cacctggcgg      720

aaaaggtgtt cctcagcacc accggagggg gatgggtgat cagccgaatc tttgactcgg      780

gctacccatg ggacatggtg ttcatgacac gctttcagaa catgttgaga aattccctcc      840

caaccccaat tgtgacttgg ttgatggagc gaaagataaa caactggctc aatcatgcaa      900

attacggctt aataccagaa gacaggactc agctgaaaga gtttgtgcta aatgatgagc      960

tcccaggacg catcatcact gggaaagtgt tcatcaggcc aagcataaaa gaggtaaagg     1020

aaaactctgt catatttaac aatacttcaa aggaagagcc tattgacatc attgtctttg     1080

ccactggata cacatttgct ttccccttcc ttgatgagtc tgtagtgaaa gttgaagatg     1140

gccaggcctc actgtacaag tatatcttcc ctgcacatct gcaaaagcca accctggcca     1200

ttattggcct catcaaaccc ttgggctcca tgatacctac aggagaaaca caagctcggt     1260

gggctgttcg agtcctgaaa ggtgtaaata agttaccacc accaagtgtc atgatagagg     1320

aaattaatgc aaggaaagaa aacaagccca gttggtttgg cttgtgctac tgcaaggctt     1380

tacaatcaga ttatatcaca tacatagatg aactcctgac ctatatcaat gcaaaaccca     1440

acctgttctc tatgctccta acggatccac atctggctct gaccgtcttc tttggcccat     1500

gctcaccata ccagttccgc ttgactggcc caggaaaatg ggaaggagcc agaaatgcca     1560

tcatgaccca gtgggaccga acattcaagg tcatcaaagc tcgagttgta caagagtctc     1620

catctccctt tgaaagtttt cttaaagtct ttagctttct ggctttgctt gtggctattt     1680

ttctgatttt cctataagta aaagatctcc taaatggaag atgcacagag tagatttaca     1740

atgctccaat tcctctctta cagcaatatt gccttcacag ttataaactg tattcaaata     1800

gtaaaggcca ccctctcgct tccctggctg gccccagggc taccactggt attcctgagc     1860

ctctcccagc tccacttcta atgctagaga atgataacta agacttctgt gcatttgaag     1920

gttgttggaa agttacaggt tcattttaga aagaaagctg ttcttgacag cactctgagc     1980

catcatacct ctttcccata taaactattt tcacagatct caactaaaac cccttacttc     2040

acaaatgatt gtgttgtgct gaaatggtgc tcttatagta ctggcttatt aaaagtaaaa     2100

aataaaccta aaaattgatt gttttaaaaa aaaa                                 2134


<210>  1038
<211>  532
<212>  PRT
<213>  Homo Sapiens

<400>  1038

Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr Glu His Val Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser Asn Ser Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys Met Tyr Ala Asn 
                85                  90                  95      


His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr Lys Val Cys Ser 
            100                 105                 110         


Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln Trp Glu Val Val 
        115                 120                 125             


Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro Leu Asp Ser Phe 
145                 150                 155                 160 


Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser His Leu Ala Glu 
        195                 200                 205             


Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val Ile Ser Arg Ile 
    210                 215                 220                 


Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met Thr Arg Phe Gln 
225                 230                 235                 240 


Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val Thr Trp Leu Met 
                245                 250                 255     


Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn Tyr Gly Leu Ile 
            260                 265                 270         


Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu Asn Asp Glu Leu 
        275                 280                 285             


Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg Pro Ser Ile Lys 
    290                 295                 300                 


Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr Ser Lys Glu Glu 
305                 310                 315                 320 


Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr Phe Ala Phe Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly Gln Ala Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro Thr Leu Ala Ile 
        355                 360                 365             


Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro Thr Gly Glu Thr 
    370                 375                 380                 


Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val Asn Lys Leu Pro 
385                 390                 395                 400 


Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg Lys Glu Asn Lys 
                405                 410                 415     


Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu Gln Ser Asp Tyr 
            420                 425                 430         


Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn Ala Lys Pro Asn 
        435                 440                 445             


Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala Leu Thr Val Phe 
    450                 455                 460                 


Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr Gly Pro Gly Lys 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp Asp Arg Thr Phe 
                485                 490                 495     


Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro Ser Pro Phe Glu 
            500                 505                 510         


Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu Val Ala Ile Phe 
        515                 520                 525             


Leu Ile Phe Leu 
    530         


<210>  1039
<211>  1992
<212>  DNA
<213>  Homo Sapiens

<400>  1039
agcaaatact cactaccaca aataagaaca tttccaaatc tgatgttctg aggattttta       60

gagcttatag tagcaaaaag aaaagggaaa ttctctctga gatgtccttt tttgtaggcc      120

taatgacaaa aggttgaaga taaagttcta gtactcattt aagtgtaata ttgaaaattg      180

atattaccaa atctggaaca accaatttaa aataaggaaa gaaagacact gtgttttcta      240

ggttaaaaat gcccagctgg caggggccaa aggagtcatt ctctactcag accctgctga      300

ctactttgct cctggggtga agtcctatcc agacggttgg aatcttcctg gaggtggtgt      360

ccagcgtgga aatatcctaa atctgaatgg tgcaggagac cctctcacac caggttaccc      420

agcaaatgaa tacgcttata ggcatggaat tgcagaggct gttggtcttc caagtattcc      480

tgttcatcca gttggatact atgatgcaca gaagctccta gaaaaaatgg gtggctcagc      540

accaccagat agcagctgga gaggaagtct caaagtgtcc tacaatgttg gacctggctt      600

tactggaaac ttttctacac aaaaagtcaa gatgcacatc cactctacca atgaagtgac      660

gagaatttac aatgtgatag gtactctcag aggagcagtg gaaccagaca gatatgtcat      720

tctgggaggt caccgggact catgggtgtt tggtggtatt gaccctcaga gtggagcagc      780

tgttgttcat gaaactgtga ggagctttgg aacactgaaa aaggaagggt ggagacctag      840

aagaacaatt ttgtttgcaa gctgggatgc agaagaattt ggtcttcttg gttctactga      900

gtgggcagag gataattcaa gactccttca agagcgtggc gtggcttata ttaatgctga      960

ctcatctata gaaggaaact acactctgag agttgattgt acaccactga tgtacagctt     1020

ggtatacaac ctaacaaaag agctgaaaag ccctgatgaa ggctttgaag gcaaatctct     1080

ttatgaaagt tggactaaaa aaagtccttc cccagagttc agtggcatgc ccaggataag     1140

caaattggga tctggaaatg attttgaggt gttcttccaa cgacttggaa ttgcttcagg     1200

cagagcacgg tatactaaaa attgggaaac aaacaaattc agcggctatc cactgtatca     1260

cagtgtctat gaaacatatg agttggtgga aaagttttat gatccaatgt ttaaatatca     1320

cctcactgtg gcccaggttc gaggagggat ggtgtttgag ctagccaatt ccatagtgct     1380

cccttttgat tgtcgagatt atgctgtagt tttaagaaag tatgctgaca aaatctacaa     1440

tatttctatg aaacatccac aggaaatgaa gacatacagt ttatcatttg attcactttt     1500

ttctgcagta aaaaatttta cagaaattgc ttccaagttc agcgagagac tccaggactt     1560

tgacaaaagc aacccaatat tgttaagaat gatgaatgat caactcatgt ttctggaaag     1620

agcatttatt gatccattag ggttaccaga cagacctttt tataggcatg tcatctatgc     1680

tccaagcagc cacaacaagt atgcagggga gtcattccca ggaatttatg atgctctgtt     1740

tgatattgaa agcaaagtgg acccttccaa ggcctgggga gatgtgaaga gacagatttc     1800

tgttgcagcc ttcacagtgc aggcagctgc agagactttg agtgaagtag cctaagagga     1860

ttctttagag actctgtatt gaatttgtgt ggtatgtcac tcaaagaata ataatgggta     1920

tattgataaa ttttaaaatt ggtatatttg aaataaagtt gaatattata tataaaaaaa     1980

aaaaaaaaaa aa                                                         1992


<210>  1040
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  1040

Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 
1               5                   10                  15      


Val Ser Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 
            20                  25                  30          


Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 
        35                  40                  45              


Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 
    50                  55                  60                  


Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 
65                  70                  75                  80  


Gln Ser Gly Ala Ala Val Val His Glu Thr Val Arg Ser Phe Gly Thr 
                85                  90                  95      


Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 
            100                 105                 110         


Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 
        115                 120                 125             


Asp Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 
    130                 135                 140                 


Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 
145                 150                 155                 160 


Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu Leu Lys Ser Pro 
                165                 170                 175     


Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 
            180                 185                 190         


Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 
        195                 200                 205             


Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 
    210                 215                 220                 


Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 
225                 230                 235                 240 


Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 
                245                 250                 255     


Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 
            260                 265                 270         


Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 
        275                 280                 285             


Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 
    290                 295                 300                 


Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 
                325                 330                 335     


Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Leu 
            340                 345                 350         


Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 
        355                 360                 365             


Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 
    370                 375                 380                 


Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 
385                 390                 395                 400 


Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 
                405                 410                 415     


Trp Gly Asp Val Lys Arg Gln Ile Ser Val Ala Ala Phe Thr Val Gln 
            420                 425                 430         


Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        435                 440         


<210>  1041
<211>  1992
<212>  DNA
<213>  Homo Sapiens

<400>  1041
agcaaatact cactaccaca aataagaaca tttccaaatc tgatgttctg aggattttta       60

gagcttatag tagcaaaaag aaaagggaaa ttctctctga gatgtccttt tttgtaggcc      120

taatgacaaa aggttgaaga taaagttcta gtactcattt aagtgtaata ttgaaaattg      180

atattaccaa atctggaaca accaatttaa aataaggaaa gaaagacact gtgttttcta      240

ggttaaaaat gcccagctgg caggggccaa aggagtcatt ctctactcag accctgctga      300

ctactttgct cctggggtga agtcctatcc agacggttgg aatcttcctg gaggtggtgt      360

ccagcgtgga aatatcctaa atctgaatgg tgcaggagac cctctcacac caggttaccc      420

agcaaatgaa tacgcttata ggcatggaat tgcagaggct gttggtcttc caagtattcc      480

tgttcatcca gttggatact atgatgcaca gaagctccta gaaaaaatgg gtggctcagc      540

accaccagat agcagctgga gaggaagtct caaagtgtcc tacaatgttg gacctggctt      600

tactggaaac ttttctacac aaaaagtcaa gatgcacatc cactctacca atgaagtgac      660

gagaatttac aatgtgatag gtactctcag aggagcagtg gaaccagaca gatatgtcat      720

tctgggaggt caccgggact catgggtgtt tggtggtatt gaccctcaga gtggagcagc      780

tgttgttcat gaaactgtga ggagctttgg aacactgaaa aaggaagggt ggagacctag      840

aagaacaatt ttgtttgcaa gctgggatgc agaagaattt ggtcttcttg gttctactga      900

gtgggcagag gataattcaa gactccttca agagcgtggc gtggcttata ttaatgctga      960

ctcatctata gaaggaaact acactctgag agttgattgt acaccactga tgtacagctt     1020

ggtatacaac ctaacaaaag agctgaaaag ccctgatgaa ggctttgaag gcaaatctct     1080

ttatgaaagt tggactaaaa aaagtccttc cccagagttc agtggcatgc ccaggataag     1140

caaattggga tctggaaatg attttgaggt gttcttccaa cgacttggaa ttgcttcagg     1200

cagagcacgg tatactaaaa attgggaaac aaacaaattc agcggctatc cactgtatca     1260

cagtgtctat gaaacatatg agttggtgga aaagttttat gatccaatgt ttaaatatca     1320

cctcactgtg gcccaggttc gaggagggat ggtgtttgag ctagccaatt ccatagtgct     1380

cccttttgat tgtcgagatt atgctgtagt tttaagaaag tatgctgaca aaatctacaa     1440

tatttctatg aaacatccac aggaaatgaa gacatacagt ttatcatttg attcactttt     1500

ttctgcagta aaaaatttta cagaaattgc ttccaagttc agcgagagac tccaggactt     1560

tgacaaaagc aacccaatat tgttaagaat gatgaatgat caactcatgt ttctggaaag     1620

agcatttatt gatccattag ggttaccaga cagacctttt tataggcatg tcatctatgc     1680

tccaagcagc cacaacaagt atgcagggga gtcattccca ggaatttatg atgctctgtt     1740

tgatattgaa agcaaagtgg acccttccaa ggcctgggga gatgtgaaga gacagatttc     1800

tgttgcagcc ttcacagtgc aggcagctgc agagactttg agtgaagtag cctaagagga     1860

ttctttagag actctgtatt gaatttgtgt ggtatgtcac tcaaagaata ataatgggta     1920

tattgataaa ttttaaaatt ggtatatttg aaataaagtt gaatattata tataaaaaaa     1980

aaaaaaaaaa aa                                                         1992


<210>  1042
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  1042

Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 
1               5                   10                  15      


Val Ser Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 
            20                  25                  30          


Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 
        35                  40                  45              


Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 
    50                  55                  60                  


Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 
65                  70                  75                  80  


Gln Ser Gly Ala Ala Val Val His Glu Thr Val Arg Ser Phe Gly Thr 
                85                  90                  95      


Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 
            100                 105                 110         


Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 
        115                 120                 125             


Asp Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 
    130                 135                 140                 


Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 
145                 150                 155                 160 


Leu Met Tyr Ser Leu Val Tyr Asn Leu Thr Lys Glu Leu Lys Ser Pro 
                165                 170                 175     


Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 
            180                 185                 190         


Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 
        195                 200                 205             


Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 
    210                 215                 220                 


Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 
225                 230                 235                 240 


Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 
                245                 250                 255     


Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 
            260                 265                 270         


Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 
        275                 280                 285             


Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 
    290                 295                 300                 


Asn Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Leu Ser 
305                 310                 315                 320 


Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 
                325                 330                 335     


Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Leu 
            340                 345                 350         


Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 
        355                 360                 365             


Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 
    370                 375                 380                 


Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 
385                 390                 395                 400 


Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 
                405                 410                 415     


Trp Gly Asp Val Lys Arg Gln Ile Ser Val Ala Ala Phe Thr Val Gln 
            420                 425                 430         


Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        435                 440         


<210>  1043
<211>  3628
<212>  DNA
<213>  Homo Sapiens

<400>  1043
agagcatcag caagagtagc agcgagcagc cgcgctggtg gcggcggcgc gtcgttgcag       60

ttgcgccatc tgtcaggagc ggagccggcg aggagggggc tgccgcgggc gaggaggagg      120

ggtcgccgcg agccgaaggc cttcgagacc cgcccgccgc ccggcggcga gagtagaggc      180

gaggttgttg tgcgagcggc gcgtcctctc ccgcccgggc gcgccgcgct tctcccagcg      240

caccgaggac cgcccgggcg cacacaaagc cgccgcccgc gccgcaccgc ccggcggccg      300

ccgcccgcgc cagggaggga ttcggccgcc gggccgggga caccccggcg ccgccccctc      360

ggtgctctcg gaaggcccac cggctcccgg gcccgccggg gaccccccgg agccgcctcg      420

gccgcgccgg aggagggcgg ggagaggacc atgtgagtgg gctccggagc ctcagcgccg      480

cgcagttttt ttgaagaagc aggatgctga tctaaacgtg gaaaaagacc agtcctgcct      540

ctgttgtaga agacatgtgg tgtatataaa gtttgtgatc gttggcggac attttggaat      600

ttagataatg ggctgtgtgc aatgtaagga taaagaagca acaaaactga cggaggagag      660

ggacggcagc ctgaaccaga gctctgggta ccgctatggc acagacccca cccctcagca      720

ctaccccagc ttcggtgtga cctccatccc caactacaac aacttccacg cagccggggg      780

ccaaggactc accgtctttg gaggtgtgaa ctcttcgtct catacgggga ccttgcgtac      840

gagaggagga acaggagtga cactctttgt ggccctttat gactatgaag cacggacaga      900

agatgacctg agttttcaca aaggagaaaa atttcaaata ttgaacagct cggaaggaga      960

ttggtgggaa gcccgctcct tgacaactgg agagacaggt tacattccca gcaattatgt     1020

ggctccagtt gactctatcc aggcagaaga gtggtacttt ggaaaacttg gccgaaaaga     1080

tgctgagcga cagctattgt cctttggaaa cccaagaggt acctttctta tccgcgagag     1140

tgaaaccacc aaaggtgcct attcactttc tatccgtgat tgggatgata tgaaaggaga     1200

ccatgtcaaa cattataaaa ttcgcaaact tgacaatggt ggatactaca ttaccacccg     1260

ggcccagttt gaaacacttc agcagcttgt acaacattac tcagagagag ctgcaggtct     1320

ctgctgccgc ctagtagttc cctgtcacaa agggatgcca aggcttaccg atctgtctgt     1380

caaaaccaaa gatgtctggg aaatccctcg agaatccctg cagttgatca agagactggg     1440

aaatgggcag tttggggaag tatggatggg tacctggaat ggaaacacaa aagtagccat     1500

aaagactctt aaaccaggca caatgtcccc cgaatcattc cttgaggaag cgcagatcat     1560

gaagaagctg aagcacgaca agctggtcca gctctatgca gtggtgtctg aggagcccat     1620

ctacatcgtc accgagtata tgaacaaagg aagtttactg gatttcttaa aagatggaga     1680

aggaagagct ctgaaattac caaatcttgt ggacatggca gcacaggtgg ctgcaggaat     1740

ggcttacatc gagcgcatga attatatcca tagagatctg cgatcagcaa acattctagt     1800

ggggaatgga ctcatatgca agattgctga cttcggattg gcccgattga tagaagacaa     1860

tgagtacaca gcaagacaag gtgcaaagtt ccccatcaag tggacggccc ccgaggcagc     1920

cctgtacggg aggttcacaa tcaagtctga cgtgtggtct tttggaatct tactcacaga     1980

gctggtcacc aaaggaagag tgccataccc aggcatgaac aaccgggagg tgctggagca     2040

ggtggagcga ggctacagga tgccctgccc gcaggactgc cccatctctc tgcatgagct     2100

catgatccac tgctggaaaa aggaccctga agaacgcccc acttttgagt acttgcagag     2160

cttcctggaa gactacttta ccgcgacaga gccccagtac caacctggtg aaaacctgta     2220

aggcccgggt ctgcggagag aggccttgtc ccagaggctg ccccacccct ccccattagc     2280

tttcaattcc gtagccagct gctccccagc agcggaaccg cccaggatca gattgcatgt     2340

gactctgaag ctgacgaact tccatggccc tcattaatga cacttgtccc caaatccgaa     2400

cctcctctgt gaagcattcg agacagaacc ttgttatttc tcagactttg gaaaatgcat     2460

tgtatcgatg ttatgtaaaa ggccaaacct ctgttcagtg taaatagtta ctccagtgcc     2520

aacaatccta gtgctttcct tttttaaaaa tgcaaatcct atgtgatttt aactctgtct     2580

tcacctgatt caactaaaaa aaaaaaagta ttattttcca aaagtggcct ctttgtctaa     2640

aacaataaaa ttttttttca tgttttaaca aaaaccaatc aggacaggtg tttgtttttg     2700

ttttcttttt tataaatatg aatatatata atatatatgt ccctgtacat atacaatgtg     2760

ggtgctaatg tggagactgt ggccggcctg agccaccaag ctgcgggacc cagagggagg     2820

attttactgc aagtcagcat caaagcaccg gtgttattct gaaaacacca gtggcctcat     2880

ttttggcttt tgcaaagcat gaattttttc atttggattg cactttcctg gttcatgact     2940

gtacctgtag gtggttgtta ctttgactct tttcaggaac caccccccaa gctgaattta     3000

caagttctgt tagcactatt tgcttcaact tactgcgatt tgttctcaaa acttaaaaat     3060

aagcaagcaa atggctgata ctaccaagag aactggaaga tggataccac acaaacttct     3120

tgtataaaaa tatgaatgct gaaatgtttc agacattttt aatttaataa acctgtaacc     3180

acatttaagt gatctaaaac ccatagcatt gtagtcatgg caacccgcta aactttctca     3240

tgcaactaaa atttctgggg gaaatgaggg tgggggttgt acatttccca ttgtaaaata     3300

agtgttttaa atgtcctgta ctgctaacga atgactttct atatgtccag gagttctcca     3360

gtggaataac tatgcactac tttacatttc atggggatgc acaaaaacaa aaaagtatta     3420

catttttagt tgctgtttgt accaacctta aattacatat gtttaacaac aacaaatcaa     3480

aaatcctatt tctattgagt ttttaatact gactagcaac tctgaagtct taattccttt     3540

tttgttatga tttatttgtg agtttacatt tttaaattgt ttaactttct taatttagta     3600

attaaaaaga gagcatttta catttgaa                                        3628


<210>  1044
<211>  537
<212>  PRT
<213>  Homo Sapiens

<400>  1044

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  1045
<211>  475
<212>  DNA
<213>  Homo Sapiens

<400>  1045
agagcagaga cctgagaggc accaggccca gccgtggcac cacacacctc ccagctctgc       60

agacgagatg cagcgactat gtgtgtatgt gctgatcttt gcactggctc tggccgcctt      120

ctctgaagct tcttggaagc cccgctccca gcagccagat gcacccttag gtacaggggc      180

caacagggac ctggagctac cctggctgga gcagcagggc ccagcctctc atcatcgaag      240

gcagctggga ccccagggtc ccccacacct cgtggcagac ccgtccaaga agcagggacc      300

atggctggag gaagaagaag aagcctatgg atggatggac ttcggccgcc gcagtgctga      360

ggatgagaac taacaatcct agaaccaagc ttcagagcct agccacctcc caccccactc      420

cagccctgtc ccctgaaaaa ctgatcaaaa ataaactagt ttccagtgga aaaaa           475


<210>  1046
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  1046

Met Gln Arg Leu Cys Val Tyr Val Leu Ile Phe Ala Leu Ala Leu Ala 
1               5                   10                  15      


Ala Phe Ser Glu Ala Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala 
            20                  25                  30          


Pro Leu Gly Thr Gly Ala Asn Arg Asp Leu Glu Leu Pro Trp Leu Glu 
        35                  40                  45              


Gln Gln Gly Pro Ala Ser His His Arg Arg Gln Leu Gly Pro Gln Gly 
    50                  55                  60                  


Pro Pro His Leu Val Ala Asp Pro Ser Lys Lys Gln Gly Pro Trp Leu 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp Phe Gly Arg Arg Ser 
                85                  90                  95      


Ala Glu Asp Glu Asn 
            100     


<210>  1047
<211>  4430
<212>  DNA
<213>  Homo Sapiens

<400>  1047
agcttcctga tttctgaagt ctgagtgatt tcctccgtgt gccgagagga aacagccttc       60

tgcactcaca gccgaaggga aagcagcagg ttggggcttc ttgtggccaa cttcagagcc      120

tgtcaccagg aaaggtaagc atgggaggaa ggaagatggc gacagatgaa gaaaatgtct      180

atggtttaga agagaacgct cagtcccggc aggagtccac gcggaggctc atccttgttg      240

ggagaacagg ggccgggaag agcgccactg ggaacagcat cctgggccag agacggttct      300

tctccaggct gggggccacg tctgtgacca gggcctgcac cacgggcagc cgcaggtggg      360

acaagtgcca cgtggaagtc gtggacactc cggacatttt cagctcccaa gtgtccaaga      420

cagatcctgg ctgtgaggag agaggtcact gctacctgct ctcggccccc ggaccccacg      480

cgctgctcct ggtgacccag ttgggtcggt tcaccgccca ggaccagcag gcggtgaggc      540

aggtgaggga catgttcggg gaggacgtcc taaaatggat ggtcatcgtc ttcaccagga      600

aggaggacct ggccgggggc tccctgcacg attacgtgag caacacagag aaccgggcct      660

tgcgcgagct ggtggccgag tgcgggggcc gggtctgtgc ctttgataac cgggccaccg      720

gccgggagca ggaagcccag gtggagcagc tgctggggat ggtcgagggc ttggtgctgg      780

agcacaaggg cgcccattac tccaacgagg tgtatgagct ggcgcaggtg ctgcgctggg      840

caggccctga ggagcggctc cggcgggtgg cggagcgcgt ggcagccagg gtgcagagga      900

ggccatgggg cgcctggctg tcggcccggc tgtggaagtg gctgaagtcc cccaggagct      960

ggaggctggg cctggccctg ctgctggggg gcgcgctcct gttctgggtg ctgctccaca     1020

ggcggtggtc ggaggccgtt gcggaggtcg ggcctgactg acagcgcagg tcctaaaact     1080

gaaggcaact tggttaaggg aggctgaatt cttggagctg aagggaaaac ttcattccaa     1140

cggaaggaat cctgtagttt caggcatagt tttaatgaca cagaaaactt tgctgcatca     1200

cctttgcaac tttgccaaag ctcagagttc actttttaag tttttaactc attttaaatg     1260

atgtgtatgc agagttttaa aataaattcg tctaacaata acttcctttg gtagttttgg     1320

tagtctaatg tcaagtagct tgtagtgggg acaaacgcat ggcacaggga aaacaagtgc     1380

cattattttc gagcttttta aaaaatttag actgcccctc cttgataatt ttctagttct     1440

tatacatggg tagataggtt cctttgtgat ccttgtagac ttttagcatc aataaaagaa     1500

atgtgggggt tacacacgtg aatgttactt ctgagacatc agtttatagt acaatgattt     1560

actaccaaaa agatgaatgt aactgtactg ttacaaagtg gaaaataaca gtttccactt     1620

ttctagaaca tattatggtt catggcattc caaaatgaag taagggccgg gcgaggtggc     1680

tcacgcctgt aatcccaaca ctttgggagg tcgaggcagg tggatcacct gaggtcagga     1740

gttcgagacc agcctgacca acatggcgaa accccatctc tactaaaaat acaaaaatta     1800

gccaggcgtg atagcactcg cctgtaatcc cagccattca ggaggctgag gcgggagaat     1860

cacttgatgc agtgagccga gatcgtgcca ctgcactcca ggctgggtga caaagcaaga     1920

atctgtctca aaaaaaaaaa aagaaaagaa aagaaaaaga aaaagagtag gatattggga     1980

aaataacata taatatcttc tatatggtta ttcatatttt tatcacacac acacacacac     2040

acacacacac acacagtctg tatctcgagc tcctctctgg ttatggagaa gaggcagagc     2100

accaggtgca taggctgaga ctgcagacac ctgagcatcc tatgctgtga ggcgaaagca     2160

tccggttttt tcgggatggg cctgtccagg aaggttctcg aatgccacgt gattagaaaa     2220

tttgccgctg actggttgtg cgaatcaaac aataggattt ccttatttct atttctgagc     2280

ataatgagaa ccctttaagg gaactcattg tctttaaatc agccagcctc tagtgaggtc     2340

atggagacat gggaagcagg tattcacatt agctctattc aagaggaaga ggaggaggga     2400

gtgtgcgcag gcgccctagg gtcttcccca gcacacgttg ggaagaaggg gtctgcaagc     2460

atgcgcacaa ttgccagctc aggctaagga ctgcaggagg ttccaggtgg gttgcgggct     2520

tcgggcaggc tatggtgagg ggtcctgagg gccttggtga ccgctgcagg gagttggact     2580

ttttgaagcg tggctcaaga aaaacccatg tttaattcct gcctttcgct tcctcagcag     2640

cctttctggg cccaggcagg ggcctcgagc cagggaagga tcctttgatg accagagggg     2700

acagcaggga gggcacagcg tggtcgtcca cggtcacttg cgcacgagcc agtgctgctg     2760

ctggtgttag acaacaactt ttatcaaagt ggtttaatgt acagcagcaa caaagctgct     2820

ttgtggagca gggctcccaa taggcagtgt gcccagagta gcagctcgga agcagtactg     2880

caatcacatt tatacccact ttcaactata tgcaaattta ggggtggatt atgccaaaat     2940

ttctagaaaa aaggtcgtaa cttccaggtc gtgggattgt tgctatggaa aggagccaaa     3000

acttccagct gttgccttag caatggtaac ctgacgtggc actggtgagt gtgttttatg     3060

gagagactct ttcacctctt ccctttcagc ttgtcttcag tgtggtctgg agcccaatcc     3120

ccacctccag agtctagtcc tgcctcctac ctcagtaata aaaagtagta gtatatggtt     3180

aattgtcaaa tacatttgca aagtgtaatc aaagatacat taccaatctg aatctcaaaa     3240

tgtgctatca tctttgaatt tgaataatgt attattaaag aagttacagt tttcctttac     3300

attcaataac atttctttag tggttttctt tttcagatac tttgattatg atcttttttt     3360

tttcatcttt gtatccccgt tatacaaccc agtgcctggc atagaaagtg ggatcaacaa     3420

atgtttggaa aatgaattgt aaagttgact ttcctgtacc tttttaatat tagatttcta     3480

gctaccagac ttttgaccat tttctaaatt ttctaccata gataacagaa aattctttcg     3540

cgcaagcatg tcattgtatt aatgatattc tcctgcccta aggaaattta cttcccttca     3600

agcacagggt cccccaaatt actgtatttc cacccctttc agcttatttt atccttttct     3660

cctgctacag aacagttggc attcaccatt cccttcggta aagtcttttt ttaggctgtg     3720

gcttaaaggt tgctttttcc cccatagctc aaggttaggc cttgtgacct cacttatgta     3780

atttgagtga tttgatagca caaatcaatt ttatacttaa attacagcat aaaacagcac     3840

tgcctcctgt tggaaaaact tgcttgctaa ttttaaccag acacagtaaa aatactgtcc     3900

aatacctcaa aaattgtgta aatatatatc catttcaatt gtcccccttc ctctcctctc     3960

cttttatctc ttggaagata aaaatgtatg ggtcctgtgc tgataatgtt tctgttcata     4020

tttctatgcc ctggtacctg gatcagcttt tgttctacac aaaaagactt gtatctggct     4080

tatttctgaa agctagtgtt ggccatgatg aacttttaga gcaaaagatt tcaggcagag     4140

tacattctta catattctta cacaatcaat attcagttcc agcccgcaca gtagccctag     4200

caaatgccag tgctccttcc agagattcac ctatggattc agtaccccag aagagaattt     4260

ctgtaaattc ttggggaagc tatagctaga ctatggctca acactcattt ttcccccatg     4320

attcttaatc taacagtggc aatgttggcc tcttcttagg caactagatt cggttcttgc     4380

ttattctgcc aataaaatac tttattgaga tgcttaaaaa aaaaaaaaaa                4430


<210>  1048
<211>  306
<212>  PRT
<213>  Homo Sapiens

<400>  1048

Met Gly Gly Arg Lys Met Ala Thr Asp Glu Glu Asn Val Tyr Gly Leu 
1               5                   10                  15      


Glu Glu Asn Ala Gln Ser Arg Gln Glu Ser Thr Arg Arg Leu Ile Leu 
            20                  25                  30          


Val Gly Arg Thr Gly Ala Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu 
        35                  40                  45              


Gly Gln Arg Arg Phe Phe Ser Arg Leu Gly Ala Thr Ser Val Thr Arg 
    50                  55                  60                  


Ala Cys Thr Thr Gly Ser Arg Arg Trp Asp Lys Cys His Val Glu Val 
65                  70                  75                  80  


Val Asp Thr Pro Asp Ile Phe Ser Ser Gln Val Ser Lys Thr Asp Pro 
                85                  90                  95      


Gly Cys Glu Glu Arg Gly His Cys Tyr Leu Leu Ser Ala Pro Gly Pro 
            100                 105                 110         


His Ala Leu Leu Leu Val Thr Gln Leu Gly Arg Phe Thr Ala Gln Asp 
        115                 120                 125             


Gln Gln Ala Val Arg Gln Val Arg Asp Met Phe Gly Glu Asp Val Leu 
    130                 135                 140                 


Lys Trp Met Val Ile Val Phe Thr Arg Lys Glu Asp Leu Ala Gly Gly 
145                 150                 155                 160 


Ser Leu His Asp Tyr Val Ser Asn Thr Glu Asn Arg Ala Leu Arg Glu 
                165                 170                 175     


Leu Val Ala Glu Cys Gly Gly Arg Val Cys Ala Phe Asp Asn Arg Ala 
            180                 185                 190         


Thr Gly Arg Glu Gln Glu Ala Gln Val Glu Gln Leu Leu Gly Met Val 
        195                 200                 205             


Glu Gly Leu Val Leu Glu His Lys Gly Ala His Tyr Ser Asn Glu Val 
    210                 215                 220                 


Tyr Glu Leu Ala Gln Val Leu Arg Trp Ala Gly Pro Glu Glu Arg Leu 
225                 230                 235                 240 


Arg Arg Val Ala Glu Arg Val Ala Ala Arg Val Gln Arg Arg Pro Trp 
                245                 250                 255     


Gly Ala Trp Leu Ser Ala Arg Leu Trp Lys Trp Leu Lys Ser Pro Arg 
            260                 265                 270         


Ser Trp Arg Leu Gly Leu Ala Leu Leu Leu Gly Gly Ala Leu Leu Phe 
        275                 280                 285             


Trp Val Leu Leu His Arg Arg Trp Ser Glu Ala Val Ala Glu Val Gly 
    290                 295                 300                 


Pro Asp 
305     


<210>  1049
<211>  1895
<212>  DNA
<213>  Homo Sapiens

<400>  1049
atgacaggaa gtgacccgtt aaggaagcag cacatcgctg cattcggctg gttttcaggg       60

tcttgttccc aatcagtttc cagccaacac cagggtgtcc tagtccgcag aggtgtgggg      120

gacacactcc ataatctcta cttttctttt tgtgcagctg agtcatggag ctttcagccc      180

cagcacatgg ctcctcctta actgcgtctg ctcaacctcc ctcagccctg tgaacagcat      240

ccccgcacac agacgcagag caggactctc tctgctgcca cttcaccttc ctgagagagg      300

accagcggcc agagcctcag tgactgccac cctggaggac agggcacaac aaccgtttct      360

ggagagaatg ggaggattcc agaggggcaa atatggaact atggctgaag gtagatcaga      420

agataacttg tctgcaacac caccggcatt gaggattatc ctagtgggca aaacaggctg      480

cgggaaaagt gccacaggga acagcatcct tggccagccc gtgtttgagt ccaagctgag      540

ggcccagtca gtgaccagga cgtgccaggt gaaaacagga acatggaacg ggaggaaagt      600

cctggtggtt gacacgccct ccatctttga gtcacaggcc gatacccaag agctgtacaa      660

gaacatcggg gactgctacc tgctctctgc cccggggccc cacgtcctgc ttctggtgat      720

ccagctgggg cgtttcactg ctcaggacac agtggccatc aggaaggtga aagaggtctt      780

tgggacaggg gccatgagac atgtggtcat cctcttcacc cacaaagagg acttaggggg      840

ccaggccctg gatgactatg tagcaaacac ggacaactgc agcctgaaag acctggtgcg      900

ggagtgtgag agaaggtact gtgccttcaa caactggggc tctgtggagg agcagaggca      960

gcagcaggca gagctcctgg ctgtgattga gaggctgggg agggagcgag agggctcctt     1020

ccacagcaat gacctcttct tggatgccca gctgctccaa agaactggag ctggggcctg     1080

ccaggaagac tacaggcagt accaggccaa agtggaatgg caggtggaga agcacaagca     1140

agagctgagg gagaacgaga gtaactgggc atacaaggcg ctcctcagag tcaaacactt     1200

gatgcttttg cattatgaga tttttgtttt tctattgttg tgcagcatac tttttttcat     1260

tatttttctg ttcatctttc attacattta aatctctgga ccctggagca cttctaatgt     1320

atcaccccat ggagtcattg ttctaataat caccaattca gactcagatc ctcgtggtct     1380

atggagcatg ctgcttgctg tctgtgcagc tcccatttcc ccttcttcct gatagacttg     1440

gagctgtgtg cctccactcc aaggctgcct gcctgctgta aacactattc cactctgtct     1500

gccaacaact gcttcaggaa tgggcctgag atcccatgca ggtccctgag aagtgagtaa     1560

aagtccgcag aggtggggat ggaagatctc tccttagata gaacctgtct tcctccctgg     1620

cattgtgggg tctgggcgtg acactgggac tctcagcagc tttgtgctgc caacctgaga     1680

ttgaaggcag tgcctcagag cagcacagag agttggggcc ccctgagccc tgagccacca     1740

gccctgcagc ctgccctatc tccgcatttc cagttgtatt agccaataga tttcctactt     1800

atttaagcta tttgagctcc gggtctcttc tacctgcatt ctaaaacatt caaagtaata     1860

aaaatttctc cacattcaaa aaaaaaaaaa aaaaa                                1895


<210>  1050
<211>  307
<212>  PRT
<213>  Homo Sapiens

<400>  1050

Met Gly Gly Phe Gln Arg Gly Lys Tyr Gly Thr Met Ala Glu Gly Arg 
1               5                   10                  15      


Ser Glu Asp Asn Leu Ser Ala Thr Pro Pro Ala Leu Arg Ile Ile Leu 
            20                  25                  30          


Val Gly Lys Thr Gly Cys Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu 
        35                  40                  45              


Gly Gln Pro Val Phe Glu Ser Lys Leu Arg Ala Gln Ser Val Thr Arg 
    50                  55                  60                  


Thr Cys Gln Val Lys Thr Gly Thr Trp Asn Gly Arg Lys Val Leu Val 
65                  70                  75                  80  


Val Asp Thr Pro Ser Ile Phe Glu Ser Gln Ala Asp Thr Gln Glu Leu 
                85                  90                  95      


Tyr Lys Asn Ile Gly Asp Cys Tyr Leu Leu Ser Ala Pro Gly Pro His 
            100                 105                 110         


Val Leu Leu Leu Val Ile Gln Leu Gly Arg Phe Thr Ala Gln Asp Thr 
        115                 120                 125             


Val Ala Ile Arg Lys Val Lys Glu Val Phe Gly Thr Gly Ala Met Arg 
    130                 135                 140                 


His Val Val Ile Leu Phe Thr His Lys Glu Asp Leu Gly Gly Gln Ala 
145                 150                 155                 160 


Leu Asp Asp Tyr Val Ala Asn Thr Asp Asn Cys Ser Leu Lys Asp Leu 
                165                 170                 175     


Val Arg Glu Cys Glu Arg Arg Tyr Cys Ala Phe Asn Asn Trp Gly Ser 
            180                 185                 190         


Val Glu Glu Gln Arg Gln Gln Gln Ala Glu Leu Leu Ala Val Ile Glu 
        195                 200                 205             


Arg Leu Gly Arg Glu Arg Glu Gly Ser Phe His Ser Asn Asp Leu Phe 
    210                 215                 220                 


Leu Asp Ala Gln Leu Leu Gln Arg Thr Gly Ala Gly Ala Cys Gln Glu 
225                 230                 235                 240 


Asp Tyr Arg Gln Tyr Gln Ala Lys Val Glu Trp Gln Val Glu Lys His 
                245                 250                 255     


Lys Gln Glu Leu Arg Glu Asn Glu Ser Asn Trp Ala Tyr Lys Ala Leu 
            260                 265                 270         


Leu Arg Val Lys His Leu Met Leu Leu His Tyr Glu Ile Phe Val Phe 
        275                 280                 285             


Leu Leu Leu Cys Ser Ile Leu Phe Phe Ile Ile Phe Leu Phe Ile Phe 
    290                 295                 300                 


His Tyr Ile 
305         


<210>  1051
<211>  3952
<212>  DNA
<213>  Homo Sapiens

<400>  1051
gaggcgctca gcacccaggg aaggcgcgtg tgtccccgat gctggctcct ccctgagccc       60

cgacggctct cgaggttctg agcctgtggc ctgcacaggg aacttcctct ccgactgcat      120

ttatgcctct gtggatgtga aggctatttc tagaaatctc ttcctttgca gaaacacccg      180

aaaccctcct gccaggaaga ccagggcctg ggaagagggt cgctctccgg ccattctccc      240

ctcaccctcc tcaccttcct cacatcctgt gccctggggg accagcagct gcttccaccc      300

agaacaagcg ggagcctgtg tcaggaaagc atgtcagagc agagctgcca gatgtccgaa      360

ctgcggctcc tcctcctggg aaaatgccgc tcgggaaaaa gtgccacagg aaatgccatt      420

ctgggcaaac atgtgttcaa gtccaagttc agtgatcaga cagtgatcaa aatgtgccag      480

agagagagtt gggtcctgag agaaaggaag gttgtggtaa ttgacacccc tgaccttttc      540

tcctcaatag cttgtgctga agacaagcaa cgcaacatcc aacactgctt ggagctctct      600

gctcccagcc tccatgctct gctcttggta attgccatcg gccatttcac aagggaggat      660

gaggaaacag ccaagggcat ccaacaagtg tttggagctg aagccaggag gcacatcatt      720

attgtcttca ctcggaagga tgatttgggg gatgacttgc tgcaagattt cattgaaaaa      780

aacaaacctc tcaagcagtt ggttcaagac tatgagggcc gatactgcat tttcaacaac      840

aagaccaata gtaaggatga gcagatcacc caggtgttgg agctccttcg caaggttgag      900

tctttggtga atacgaacgg aggaccctat catgtgaact tcaaaactga aggcagcagg      960

tttcaagatt gtgtgaatga agctgcatct caagagggag acaagccaca gggcccaagg     1020

gaaaggcagc tgcagtccac aggacccgag cagaatccgg ggacatcaga actgacagtc     1080

ctccttgtgg ggaaacgcgg tgctggaaaa agtgcagcag gaaacagcat tctggggagg     1140

caggcctttc agaccggatt tagtgagcag tcagtaaccc agagcttctt gtctgagagc     1200

agaagctgga gaaaaaagaa agtttcgatc attgatgctc cggacatctc atctttaaag     1260

aacattgact cagaagttag aaaacacatc tgtacaggcc cccatgcctt cctgctggtg     1320

acaccactgg gcttttacac taagaatgat gaggcagtgc tgagcaccat ccaaaacaat     1380

tttggagaaa aattctttga gtacatgatc atacttctta ccaggaaaga agatttaggg     1440

gatcaggatc tagatacgtt cttaagaaac agcaataaag ctctctatgg tctcatccag     1500

aagtgtaaaa acagatatag tgccttcaac taccgggcaa caggagaaga agagcaaagg     1560

caggcggacg agctcctgga aaaaattgag agcatggtgc atcagaatgg gaacaagcat     1620

tgcgttttca gagaaaaaga aaccctgaac attgtccttg tggggagaag cgggactggg     1680

aagagtgcga ccgggaactc tatcctgggg agcctcgtct tcacctctcg gctccgggcc     1740

cagccagtca ccaagaccag ccagagtggc aggaggacat gggacggaca ggaggtggtg     1800

gttgtggaca ctccttcctt caaccagatg ctggatgtcg aaaaggaccc atcccggtta     1860

gaagaggagg tcaagcgctg tttgtcctgc tgtgaaaaag gggacacatt ttttgtcctg     1920

gtgttccagc tgggacgatt cactgaagag gacaaaacag ctgtggcgaa actggaggcc     1980

atctttggag cagactttac gaaatacgcg attatgctgt tcacccggaa ggaagaccta     2040

ggggcgggga atttggaaga cttcatgaag aactcagata acaaagccct tcggcgcatt     2100

tttaaaaagt gtgggcggcg agtttgtgct tttaacaaca aagaaacagg ccaggcccag     2160

gaaacccagg tgaaagctct tttaacaaag gtcaatgatc tgagaaaaga aagtgggtgg     2220

tccgggtatc cccatacaca ggagaacgtc agcaaactaa ttaaaaatgt ccaggaaatg     2280

tcccaagccg aaaaactcct taaaaattta ataggtattt tacaataggt agccgaagtg     2340

cctggggtct cttcaattag agacaccctc aggttggggg gaggggcggg gcatggtaca     2400

acctgtggga agggaagcgg gttcatggct ttgagggcct gagaggcaaa tgcatcccgc     2460

cttgtgatgt atcagctatt tgtagataaa taaattgcag gtgggggcga atagtagggt     2520

attataaagg agaaagaaga tacaaggtgg ggaaatctgg aaaaagattt cagacattag     2580

gctgataata agtggtagaa tcaagtcaca agaatcacct cacttgtgta ggtaggttgg     2640

aatcaggata gacactgtga tcaaggctga ggccacctgg gatgagaata tagatagtcg     2700

tacaacaacc caggggatcc agatacatga gaccagggca gcgttcagca cactcctggg     2760

catggcggaa gcaggaagca gactccagag ggcctccctg ttgtccaggg ccgttggctc     2820

cctgagctct cctgtctcct ttgggatgcg acttagggct agagtgttct tttcttcaca     2880

cgttagccat tccttacggc tcttcacgtt ccacgcctag atgtgaagtg ggacatagtc     2940

ttccattgct ggctgtccct gaggaaacag acatgagtct tggaggttct gaatgatttt     3000

attgctaatt atcacagtga catagactag aacagaaatt agaagcatag taagattgcc     3060

aaaatcagag aatcttgcaa agttctgtaa ttctaagtgt tgttctagat ttcctctaga     3120

gaaggttatt agaatctcca ttgcgtttct ctttctcctt ctctttccct tgaggttagg     3180

aaacaggtta aaactcagag aactccaata ataatggttt aaaaacatca ggggcttcct     3240

gtatctcctg tcaggaagcc gaggaataag caggctgggg ctggtgggcg tcaacatccc     3300

agttttgttc tatctttctg tcccacctgc actgggatgt ggcttctaca ctcgaatttg     3360

cttcttggtt tcaagacagt ggtgttcttt ccatagctga gcagattatt ttgagaggtg     3420

ggtgatatgt gagagagaaa tctggaacct tcttctgggt agatacagga taagatagat     3480

acagggtaaa atgttgagca ctttgtacat gctttgagag cataatcttt gtcatctgtt     3540

tttttcccct agacaatatc aggttaccgt caacattaat ccatttaaaa ggacatggac     3600

tgttgccatt aatacttttg gattccatat aacccttaac acaataactt ctagaaaatg     3660

tgtgtgccgt agacacaaag aagggaacaa tagacaccag ggtatacttg agggtggagg     3720

gtggcaggag ggtgaagatt gaaaagctgc ctattgcgtg ttatgctggt ttcctgggtg     3780

acaaaattac ctgtacacca cacccctgtg acacacaact tactcatgta acaaacctgt     3840

gcatgtaccc cttgaacctg aaataaaaat tggaaagtaa aaaaaagtgt gtaaatatat     3900

ttagttgaat caaataataa agatgaatca ttatgaattc acaaaaaaaa aa             3952


<210>  1052
<211>  665
<212>  PRT
<213>  Homo Sapiens

<400>  1052

Met Ser Glu Gln Ser Cys Gln Met Ser Glu Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Gly Lys Cys Arg Ser Gly Lys Ser Ala Thr Gly Asn Ala Ile Leu Gly 
            20                  25                  30          


Lys His Val Phe Lys Ser Lys Phe Ser Asp Gln Thr Val Ile Lys Met 
        35                  40                  45              


Cys Gln Arg Glu Ser Trp Val Leu Arg Glu Arg Lys Val Val Val Ile 
    50                  55                  60                  


Asp Thr Pro Asp Leu Phe Ser Ser Ile Ala Cys Ala Glu Asp Lys Gln 
65                  70                  75                  80  


Arg Asn Ile Gln His Cys Leu Glu Leu Ser Ala Pro Ser Leu His Ala 
                85                  90                  95      


Leu Leu Leu Val Ile Ala Ile Gly His Phe Thr Arg Glu Asp Glu Glu 
            100                 105                 110         


Thr Ala Lys Gly Ile Gln Gln Val Phe Gly Ala Glu Ala Arg Arg His 
        115                 120                 125             


Ile Ile Ile Val Phe Thr Arg Lys Asp Asp Leu Gly Asp Asp Leu Leu 
    130                 135                 140                 


Gln Asp Phe Ile Glu Lys Asn Lys Pro Leu Lys Gln Leu Val Gln Asp 
145                 150                 155                 160 


Tyr Glu Gly Arg Tyr Cys Ile Phe Asn Asn Lys Thr Asn Ser Lys Asp 
                165                 170                 175     


Glu Gln Ile Thr Gln Val Leu Glu Leu Leu Arg Lys Val Glu Ser Leu 
            180                 185                 190         


Val Asn Thr Asn Gly Gly Pro Tyr His Val Asn Phe Lys Thr Glu Gly 
        195                 200                 205             


Ser Arg Phe Gln Asp Cys Val Asn Glu Ala Ala Ser Gln Glu Gly Asp 
    210                 215                 220                 


Lys Pro Gln Gly Pro Arg Glu Arg Gln Leu Gln Ser Thr Gly Pro Glu 
225                 230                 235                 240 


Gln Asn Pro Gly Thr Ser Glu Leu Thr Val Leu Leu Val Gly Lys Arg 
                245                 250                 255     


Gly Ala Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Gly Arg Gln Ala 
            260                 265                 270         


Phe Gln Thr Gly Phe Ser Glu Gln Ser Val Thr Gln Ser Phe Leu Ser 
        275                 280                 285             


Glu Ser Arg Ser Trp Arg Lys Lys Lys Val Ser Ile Ile Asp Ala Pro 
    290                 295                 300                 


Asp Ile Ser Ser Leu Lys Asn Ile Asp Ser Glu Val Arg Lys His Ile 
305                 310                 315                 320 


Cys Thr Gly Pro His Ala Phe Leu Leu Val Thr Pro Leu Gly Phe Tyr 
                325                 330                 335     


Thr Lys Asn Asp Glu Ala Val Leu Ser Thr Ile Gln Asn Asn Phe Gly 
            340                 345                 350         


Glu Lys Phe Phe Glu Tyr Met Ile Ile Leu Leu Thr Arg Lys Glu Asp 
        355                 360                 365             


Leu Gly Asp Gln Asp Leu Asp Thr Phe Leu Arg Asn Ser Asn Lys Ala 
    370                 375                 380                 


Leu Tyr Gly Leu Ile Gln Lys Cys Lys Asn Arg Tyr Ser Ala Phe Asn 
385                 390                 395                 400 


Tyr Arg Ala Thr Gly Glu Glu Glu Gln Arg Gln Ala Asp Glu Leu Leu 
                405                 410                 415     


Glu Lys Ile Glu Ser Met Val His Gln Asn Gly Asn Lys His Cys Val 
            420                 425                 430         


Phe Arg Glu Lys Glu Thr Leu Asn Ile Val Leu Val Gly Arg Ser Gly 
        435                 440                 445             


Thr Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu Gly Ser Leu Val Phe 
    450                 455                 460                 


Thr Ser Arg Leu Arg Ala Gln Pro Val Thr Lys Thr Ser Gln Ser Gly 
465                 470                 475                 480 


Arg Arg Thr Trp Asp Gly Gln Glu Val Val Val Val Asp Thr Pro Ser 
                485                 490                 495     


Phe Asn Gln Met Leu Asp Val Glu Lys Asp Pro Ser Arg Leu Glu Glu 
            500                 505                 510         


Glu Val Lys Arg Cys Leu Ser Cys Cys Glu Lys Gly Asp Thr Phe Phe 
        515                 520                 525             


Val Leu Val Phe Gln Leu Gly Arg Phe Thr Glu Glu Asp Lys Thr Ala 
    530                 535                 540                 


Val Ala Lys Leu Glu Ala Ile Phe Gly Ala Asp Phe Thr Lys Tyr Ala 
545                 550                 555                 560 


Ile Met Leu Phe Thr Arg Lys Glu Asp Leu Gly Ala Gly Asn Leu Glu 
                565                 570                 575     


Asp Phe Met Lys Asn Ser Asp Asn Lys Ala Leu Arg Arg Ile Phe Lys 
            580                 585                 590         


Lys Cys Gly Arg Arg Val Cys Ala Phe Asn Asn Lys Glu Thr Gly Gln 
        595                 600                 605             


Ala Gln Glu Thr Gln Val Lys Ala Leu Leu Thr Lys Val Asn Asp Leu 
    610                 615                 620                 


Arg Lys Glu Ser Gly Trp Ser Gly Tyr Pro His Thr Gln Glu Asn Val 
625                 630                 635                 640 


Ser Lys Leu Ile Lys Asn Val Gln Glu Met Ser Gln Ala Glu Lys Leu 
                645                 650                 655     


Leu Lys Asn Leu Ile Gly Ile Leu Gln 
            660                 665 


<210>  1053
<211>  1779
<212>  DNA
<213>  Homo Sapiens

<400>  1053
gtcgccccgg gacggggagg tggggagctg agggcaagtc gcgcccgccc ctgaaatccc       60

agccgcctag cgattggctg caagggtctc ggcttggccg cggattggtc acacccgagg      120

gcttgaaagg tggctgggag cgccggacac ctcagacgga cggtggccag ggatcaggca      180

gcggctcagg cgaccctgag tgtgccccca ccccgccatg gcccggctgc tgcaggcgtc      240

ctgcctgctt tccctgctcc tggccggctt cgtctcgcag agccggggac aagagaagtc      300

gaagatggac tgccatggtg gcataagtgg caccatttac gagtacggag ccctcaccat      360

tgatggggag gagtacatcc ccttcaagca gtatgctggc aaatacgtcc tctttgtcaa      420

cgtggccagc tactgaggcc tgacgggcca gtacattgaa ctgaatgcac tacaggaaga      480

gcttgcacca ttcggtctgg tcattctggg ctttccctgc aaccaatttg gaaaacagga      540

accaggagag aactcagaga tccttcctac cctcaagtat gtccgaccag gtggaggctt      600

tgtccctaat ttccagctct ttgagaaagg ggatgtcaat ggagagaaag agcagaaatt      660

ctacactttc ctaaagaact cctgtcctcc cacctcggag ctcctgggta catctgaccg      720

cctcttctgg gaacccatga aggttcacga catccgctgg aactttgaga agttcctggt      780

ggggccagat ggtataccca tcatgcgctg gcaccaccgg accacggtca gcaacgtcaa      840

gatggacatc ctgtcctaca tgaggcggca ggcagccctg ggggtcaaga ggaagtaact      900

gaaggccgtc tcatcccatg tccaccatgt aggggaggga ctttgttcag gaagaaatcc      960

gtgtctccaa ccacactatc tacccatcac agaccccttt cctatcactc aaggccccag     1020

cctggcacaa atggatgcat acagttctgt gtactgccag gcatgtgggt gtgggtgcat     1080

gtgggtgttt acacacatgc ctacaggtat gcgtgattgt gtgtgtgtgc atgggtgtac     1140

agccacgtgt ctacctatgt gtctttctgg gaatgtgtac catctgtgtg cctgcagctg     1200

tgtagtgctg gacagtgaca accctttctc tccagttctc cactccaatg ataatagttc     1260

acttacacct aaacccaaag gaaaaaccag ctctaggtcc aattgttctg ctctaactga     1320

tacctcaacc ttggggccag catctcccac tgcctccaaa tattagtaac tatgactgac     1380

gtccccagaa gtttctgggt ctaccacact ccccaacccc ccactcctac ttcctgaagg     1440

gccctcccaa ggctacatcc ccaccccaca gttctccctg agagagatca acctccctga     1500

gatcaaccaa ggcagatgtg acagcaaggg ccacggaccc catggcaggg gtggcgtctt     1560

catgagggag gggcccaaag cccttgtggg cggacctccc ctgagcctgt ctgaggggcc     1620

agcccttagt gcattcaggc taaggcccct gggcagggat gccacccctg ctccttcgga     1680

ggacgtgccc tcacccctca ctggtccact ggcttgagac tcaccccgtc tgcccagtaa     1740

aagcctttct gcagcagctg aaaaaaaaaa aaaaaaaaa                            1779


<210>  1054
<211>  225
<212>  PRT
<213>  Homo Sapiens

<400>  1054

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Gly Leu Thr Gly Gln Tyr Ile Glu 
65                  70                  75                  80  


Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile Leu 
                85                  90                  95      


Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn Ser 
            100                 105                 110         


Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe Val 
        115                 120                 125             


Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys Glu 
    130                 135                 140                 


Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser Glu 
145                 150                 155                 160 


Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val His 
                165                 170                 175     


Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Ile 
            180                 185                 190         


Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys Met 
        195                 200                 205             


Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys Arg 
    210                 215                 220                 


Lys 
225 


<210>  1055
<211>  908
<212>  RNA
<213>  Homo Sapiens

<400>  1055
gaggaggcgg gagcgcgcca gagacggcgg gcagcccgcc cgcggccggg agcacaggca       60

aagccagcgg gcccgagccg ggggacggag aacaacgcag cggaggagaa agcaccaaca      120

gcagcggcag ccaagaccca ccccagggcc agggcgcaac aagagagagc cgaagacaca      180

gagagagcag cagaggccgc acccacacaa gcaacagagg aaggagcagg cggcgggagc      240

cgaagcccaa gaaagcacac agggaggaag gagcaacccg aaaaccagcc agacacaaac      300

aggcgggaaa ccagacccgc aaggcagaac cagcaaggga agggcgaagc agaaaacaaa      360

gcgggacaac caggcgggac ccagggccag cgaagggcgg ggccaacccg gggccgaccg      420

agcacgaaca ccccgccacc gaccggggag gagggagcca caccaaagcc ggaccccccc      480

agccggaccg gaccaaccca ccacgcagca gacaaggggg ccgagggagg accgggaaca      540

gcacaccgga cgcaacacgg gcaccggagg acagcgcagc gcccgcccag gagaagggaa      600

gacacacaac ccaacagagc gcgaggaggg aaacgcaagg gcaccaggac cacccgagca      660

ggaagagacc agaaaagcgc agagcagacc acgggcggac aaaaacgcag aaaaacgggg      720

gagagccacg gaagccgaca gacaaccagc gcaggcggaa accaagagaa gcaccaagca      780

ggcgcgcaag agagcacggc gcacccgcca ggggaagaaa acgacccaga aggaaggaac      840

cgaaggacaa gagggcgaag gcggcaccgc ccccacccac cgcaaaagga ccaaaaaacc      900

ccacacac                                                               908


<210>  1056
<211>  2448
<212>  DNA
<213>  Homo Sapiens

<400>  1056
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt       60

gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct      120

gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag      180

aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt      240

cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc      300

tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc      360

tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag      420

gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga      480

attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga      540

ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag      600

gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc      660

ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg      720

gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa      780

tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg      840

gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg      900

ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga      960

atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag     1020

agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg     1080

agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt     1140

gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt     1200

tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag     1260

cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac     1320

tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag     1380

agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg     1440

acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga     1500

taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta     1560

aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg     1620

gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct     1680

ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg     1740

catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg     1800

ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc     1860

actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat     1920

gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta     1980

tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta     2040

tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat     2100

ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga     2160

ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg     2220

acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat     2280

taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata     2340

ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt     2400

ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa                  2448


<210>  1057
<211>  301
<212>  PRT
<213>  Homo Sapiens

<400>  1057

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  1058
<211>  1413
<212>  DNA
<213>  Homo Sapiens

<400>  1058
ttgtgattgt ttttagtttg ttagctgcct ggagtgttat tttaagaaag cagaagcacc       60

atcatttgca cactccttat agatcacaca ccttaaccct gacttttttt gctccagttt      120

ttcagaagaa gtgaagtcaa gatgaagaac catttgcttt tctggggagt cctggcggtt      180

tttattaagg ctgttcatgt gaaagcccaa gaagatgaaa ggattgttct tgttgacaac      240

aaatgtaagt gtgcccggat tacttccagg atcatccgtt cttccgaaga tcctaatgag      300

gacattgtgg agagaaacat ccgaattatt gttcctctga acaacaggga gaatatctct      360

gatcccacct caccattgag aaccagattt gtgtaccatt tgtctgacct ctgtaaaaaa      420

tgtgatccta cagaagtgga gctggataat cagatagtta ctgctaccca gagcaatatc      480

tgtgatgaag acagtgctac agagacctgc tacacttatg acagaaacaa gtgctacaca      540

gctgtggtcc cactcgtata tggtggtgag accaaaatgg tggaaacagc cttaacccca      600

gatgcctgct atcctgacta atttaagtca ttgctgactg catagctctt tttcttgaga      660

ggctctccat tttgattcag aaagttagca tatttattac caatgaattt gaaaccaggg      720

cttttttttt tttttgggtg atgtaaaacc aactccctgc caccaaaata attaaaatag      780

tcacattgtt atctttatta ggtaatcact tcttaattat atgttcatac tctaagtatc      840

aaaatcttcc aattatcatg ctcacctgaa agaggtatgc tctcttagga atacagtttc      900

tagcattaaa caaataaaca aggggagaaa ataaaactca aggactgaaa atcaggaggt      960

gtaataaaat gttcctcgca ttcccccccg cttttttttt tttttttgac tttgccttgg     1020

agagccagag cttccgcatt ttctttacta ttctttttaa aaaaagtttc actgtgtaga     1080

gaacatatat gcataaacat aggtcaatta tatgtctcca ttagaaaaat aataattgga     1140

aaacatgttc tagaactagt tacaaaaata atttaaggtg aaatctctaa tatttataaa     1200

agtagcaaaa taaatgcata attaaaatat atttggacat aacagacttg gaagcagatg     1260

atacagactt ctttttttca taatcaggtt agtgtaagaa attgccattt gaaacaatcc     1320

attttgtaac tgaaccttat gaaatatatg tatttcatgg tacgtattct ctagcacagt     1380

ctgagcaatt aaatagattc ataagcataa aaa                                  1413


<210>  1059
<211>  159
<212>  PRT
<213>  Homo Sapiens

<400>  1059

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  1060
<211>  347
<212>  DNA
<213>  Homo Sapiens

<400>  1060
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      180

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      300

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctcc                    347


<210>  1061
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  1061

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Asn Trp Pro Pro 
        115     


<210>  1062
<211>  1484
<212>  DNA
<213>  Homo Sapiens

<400>  1062
cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg       60

ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg      120

gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc      180

tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagcaa tgttgcgctt      240

gtacgtgttg gtaatgggag tttctgcctt cacccttcag cctgcggcac acacaggggc      300

tgccagaagc tgccggtttc gtgggaggca ttacaagcgg gagttcaggc tggaagggga      360

gcctgtagcc ctgaggtgcc cccaggtgcc ctactggttg tgggcctctg tcagcccccg      420

catcaacctg acatggcata aaaatgactc tgctaggacg gtcccaggag aagaagagac      480

acggatgtgg gcccaggacg gtgctctgtg gcttctgcca gccttgcagg aggactctgg      540

cacctacgtc tgcactacta gaaatgcttc ttactgtgac aaaatgtcca ttgagctcag      600

agtttttgag aatacagatg ctttcctgcc gttcatctca tacccgcaaa ttttaacctt      660

gtcaacctct ggggtattag tatgccctga cctgagtgaa ttcacccgtg acaaaactga      720

cgtgaagatt caatggtaca aggattctct tcttttggat aaagacaatg agaaatttct      780

aagtgtgagg gggaccactc acttactcgt acacgatgtg gccctggaag atgctggcta      840

ttaccgctgt gtcctgacat ttgcccatga aggccagcaa tacaacatca ctaggagtat      900

tgagctacgc atcaagaaaa aaaaagaaga gaccattcct gtgatcattt cccccctcaa      960

gaccatatca gcttctctgg ggtcaagact gacaatcccg tgtaaggtgt ttctgggaac     1020

cggcacaccc ttaaccacca tgctgtggtg gacggccaat gacacccaca tagagagcgc     1080

ctacccggga ggccgcgtga ccgaggggcc acgccaggaa tattcagaaa ataatgagaa     1140

ctacattgaa gtgccattga tttttgatcc tgtcacaaga gaggatttgc acatggattt     1200

taaatgtgtt gtccataata ccctgagttt tcagacacta cgcaccacag tcaaggaagc     1260

ctcctccacg ttctcctggg gcattgtgct ggccccactt tcactggcct tcttggtttt     1320

ggggggaata tggatgcaca gacggtgcaa acacagaact ggaaaagcag atggtctgac     1380

tgtgctatgg cctcatcatc aagactttca atcctatccc aagtgaaata aatggaatga     1440

aataattcaa acacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1484


<210>  1063
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  1063

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  1064
<211>  3357
<212>  DNA
<213>  Homo Sapiens

<400>  1064
gtgatgctgc tgctgctgct gctgctgccg ccgccgcctc tattgctgat actctagtgg       60

ggctggaagg gtggttccta ttcgcaccat cgccaaccag agacagaggg aaaaaaaaaa      120

ccggcagcca ctgctgatgt tgggttcgga ggctgcatcc gactcggtca caaggaaaat      180

ggattcagtt tgcatctctc cctcctttaa acagcttctc cgggtctcag catgggcttc      240

cagggcagcg attgaggaga ccttaccaag gagcaccaca cagtagatgc tgagacatcg      300

tactccagga taagaaacag taacatggca gcacctgctt gaaagaaatt aaaaaccaac      360

agactccatt tagaaaggaa caatgtccaa gaaagggcga aataagggcg agaagcccga      420

ggcactcatt gttgcccttc aagctgccaa tgaagacctc aggaccaagc tcacagacat      480

tcagatagag ctgcatcaag agaagtccaa ggtatcaaag cttgaaagag agaagactca      540

agaagcgaag aggattcgtg agctggagca gcgcaagcac acggtgctgg tgacagaact      600

caaagccaag ctccatgagg agaagatgaa ggagctgcag gctgtgaggg agaaccttat      660

caagcagcac gagcaggaaa tgtcaaggac ggtgaaggta cgtgatggag agatccagag      720

gctcaagtct gctctctgtg ctctccgcga cggcagcagt gacaaagtaa ggacagcgct      780

caccattgag gcccgggagg aggcccggaa actgtttgac acagagcgcc ttaagctctt      840

acaggaaatt gcggacctga aaacggccaa gaagcaggtg gacgaggctc tgagcaatat      900

gatccaagca gataaaatca aggctgggga ccttcggagt gagcatcagt cccaccaaga      960

agccatctcg aagatcaagt gggagtcgga gcgggatatt cggaggctga tggatgaaat     1020

caaagccaag gacaggatca tcttttccct ggaaaaggaa ctggagaccc agacaggcta     1080

tgtacagaaa ctccaacttc agaaggaggc tttggacgaa caactctttc tggtcaagga     1140

ggctgagtgc aacatgagca gcccaaaacg agaaattcca ggaagggcag gtgatggttc     1200

cgaacactgc agcagtcctg atttgcgaag aaatcaaaag agaatagctg aattgaatgc     1260

cactataaga aaattagaag acaggaatac cttgcttgga gatgaacgaa atgaactgtt     1320

aaaacgtgtg cgggaaaccg aaaagcaatg taaacctctc ctggaaagga acaagtgcct     1380

cgccaagaga aacgatgaac tgatggtgtc cttgcagcgc atggaagaaa aactaaaagc     1440

cgttaccaag gaaaattcag aaatgagaga aaaaataaca tcccatccac ccctgaagaa     1500

attaaaatct ctgaatgacc tcgaccaagc taatgaagaa caagaaacag agtttctaaa     1560

acttcaggtc attgagcaac agaacattat tgatgagctc acaagggacc gagaaaagct     1620

catccgtaga agaaagcata gaagaagttc caagccaatt aagaggcctg ttttggaccc     1680

gtttattggc tatgatgagg actctatgga ttcagagaca tcatccatgg cctcatttag     1740

aacagacaga acaccagcta ctcctgatga tgacttggat gaaagtttag cagctgaaga     1800

atctgaacta agatttcgac aattaacaaa agaatatcag gccctccaaa gagcatatgc     1860

cctcctacag gagcagacgg gaggcatcat cgacgctgaa cgagaagcca aggctcaaga     1920

acagctccaa gcagaggtgc taaggtataa agccaaaatt gaagacctgg aagcgactct     1980

ggctcagaaa gggcaggatt cacactgggt agaagataaa caacttttca ttaagagaaa     2040

ccaggagctt ttagaaaaga tagaaaaaca ggaggcagaa aatcaccggt tacaacaaga     2100

actacaggac gccagagacc agaatgagct gctggagttt cgaaacctag agctagaaga     2160

gagagagaga cgatcccctc catttaatct ccaaattcac ccattctcag atggtgtgag     2220

tgctctacag atctactgta tgaaagaagg tgttaaggat gtgaacatcc ctgatctcat     2280

aaagcagctt gatatcttgg gtgataatgg gaatttaaga aatgaagaac aagtggccat     2340

aattcaggcc agcactgtgc tgtccctggc agagaagtgg atccagcaga ttgaaggagc     2400

tgaggctgcc ctacaccaga aaatgatgga attggaaagt gacatggaac agttctgcaa     2460

aataaaaggc tatctggagg aagaactaga ctacagaaaa caagctcttg accaagcata     2520

tatgagaatc caggaactag aagctacttt gtacaatgct ctacagcaag aaactgttat     2580

caagtttggt gaattattaa gtgaaaaaca gcaagaggag ctgaggacgg cagtagaaaa     2640

gttacggcgg caaatgctga ggaagagcag agagtatgac tgtcagattc ttcaggagag     2700

aatggagctc ttacagcaag cccatcagag aattcgtgac ttagaagata aaacagacat     2760

ccagaaaaga caaataaaag acttagaaga aaagagtaac cgaaaacatg gataagatcc     2820

caggaagaca agtgcttcta aaccttcaaa gatggcaaaa ttgtttacac cagtgagagg     2880

gagatcaaaa gctaagaact accctgtagc caggactaca actgtgtatt ttaaagccat     2940

tattcaaggt ttcttacttg acagttccta cacaaccctg ttgaaaatct acaatatatg     3000

ctgcatttaa tgaaacatgt atatgtcaaa tcagaagaga agaactataa acatatattg     3060

tgtaaagaaa aagttcagca atggaactag tttctgcaga tcaagcaaag atgtgtcttg     3120

ggcatggaac caaagttaca atgaaatatt caacccctgc tgtgcagggg ggtcatttta     3180

atgtaacacc acaccccatg gaaacactag tcctgataat aaacatcatt ttaaaagatc     3240

aaaacaaaca aacaaaaaaa acaagggtgg gtggggagtg aagcacgagg aatacctatg     3300

aagagctatt tacaataaaa tgtttcattt gaaaagtcaa aaaaaaaaaa aaaaaaa        3357


<210>  1065
<211>  810
<212>  PRT
<213>  Homo Sapiens

<400>  1065

Met Ser Lys Lys Gly Arg Asn Lys Gly Glu Lys Pro Glu Ala Leu Ile 
1               5                   10                  15      


Val Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Thr Lys Leu Thr Asp 
            20                  25                  30          


Ile Gln Ile Glu Leu His Gln Glu Lys Ser Lys Val Ser Lys Leu Glu 
        35                  40                  45              


Arg Glu Lys Thr Gln Glu Ala Lys Arg Ile Arg Glu Leu Glu Gln Arg 
    50                  55                  60                  


Lys His Thr Val Leu Val Thr Glu Leu Lys Ala Lys Leu His Glu Glu 
65                  70                  75                  80  


Lys Met Lys Glu Leu Gln Ala Val Arg Glu Asn Leu Ile Lys Gln His 
                85                  90                  95      


Glu Gln Glu Met Ser Arg Thr Val Lys Val Arg Asp Gly Glu Ile Gln 
            100                 105                 110         


Arg Leu Lys Ser Ala Leu Cys Ala Leu Arg Asp Gly Ser Ser Asp Lys 
        115                 120                 125             


Val Arg Thr Ala Leu Thr Ile Glu Ala Arg Glu Glu Ala Arg Lys Leu 
    130                 135                 140                 


Phe Asp Thr Glu Arg Leu Lys Leu Leu Gln Glu Ile Ala Asp Leu Lys 
145                 150                 155                 160 


Thr Ala Lys Lys Gln Val Asp Glu Ala Leu Ser Asn Met Ile Gln Ala 
                165                 170                 175     


Asp Lys Ile Lys Ala Gly Asp Leu Arg Ser Glu His Gln Ser His Gln 
            180                 185                 190         


Glu Ala Ile Ser Lys Ile Lys Trp Glu Ser Glu Arg Asp Ile Arg Arg 
        195                 200                 205             


Leu Met Asp Glu Ile Lys Ala Lys Asp Arg Ile Ile Phe Ser Leu Glu 
    210                 215                 220                 


Lys Glu Leu Glu Thr Gln Thr Gly Tyr Val Gln Lys Leu Gln Leu Gln 
225                 230                 235                 240 


Lys Glu Ala Leu Asp Glu Gln Leu Phe Leu Val Lys Glu Ala Glu Cys 
                245                 250                 255     


Asn Met Ser Ser Pro Lys Arg Glu Ile Pro Gly Arg Ala Gly Asp Gly 
            260                 265                 270         


Ser Glu His Cys Ser Ser Pro Asp Leu Arg Arg Asn Gln Lys Arg Ile 
        275                 280                 285             


Ala Glu Leu Asn Ala Thr Ile Arg Lys Leu Glu Asp Arg Asn Thr Leu 
    290                 295                 300                 


Leu Gly Asp Glu Arg Asn Glu Leu Leu Lys Arg Val Arg Glu Thr Glu 
305                 310                 315                 320 


Lys Gln Cys Lys Pro Leu Leu Glu Arg Asn Lys Cys Leu Ala Lys Arg 
                325                 330                 335     


Asn Asp Glu Leu Met Val Ser Leu Gln Arg Met Glu Glu Lys Leu Lys 
            340                 345                 350         


Ala Val Thr Lys Glu Asn Ser Glu Met Arg Glu Lys Ile Thr Ser His 
        355                 360                 365             


Pro Pro Leu Lys Lys Leu Lys Ser Leu Asn Asp Leu Asp Gln Ala Asn 
    370                 375                 380                 


Glu Glu Gln Glu Thr Glu Phe Leu Lys Leu Gln Val Ile Glu Gln Gln 
385                 390                 395                 400 


Asn Ile Ile Asp Glu Leu Thr Arg Asp Arg Glu Lys Leu Ile Arg Arg 
                405                 410                 415     


Arg Lys His Arg Arg Ser Ser Lys Pro Ile Lys Arg Pro Val Leu Asp 
            420                 425                 430         


Pro Phe Ile Gly Tyr Asp Glu Asp Ser Met Asp Ser Glu Thr Ser Ser 
        435                 440                 445             


Met Ala Ser Phe Arg Thr Asp Arg Thr Pro Ala Thr Pro Asp Asp Asp 
    450                 455                 460                 


Leu Asp Glu Ser Leu Ala Ala Glu Glu Ser Glu Leu Arg Phe Arg Gln 
465                 470                 475                 480 


Leu Thr Lys Glu Tyr Gln Ala Leu Gln Arg Ala Tyr Ala Leu Leu Gln 
                485                 490                 495     


Glu Gln Thr Gly Gly Ile Ile Asp Ala Glu Arg Glu Ala Lys Ala Gln 
            500                 505                 510         


Glu Gln Leu Gln Ala Glu Val Leu Arg Tyr Lys Ala Lys Ile Glu Asp 
        515                 520                 525             


Leu Glu Ala Thr Leu Ala Gln Lys Gly Gln Asp Ser His Trp Val Glu 
    530                 535                 540                 


Asp Lys Gln Leu Phe Ile Lys Arg Asn Gln Glu Leu Leu Glu Lys Ile 
545                 550                 555                 560 


Glu Lys Gln Glu Ala Glu Asn His Arg Leu Gln Gln Glu Leu Gln Asp 
                565                 570                 575     


Ala Arg Asp Gln Asn Glu Leu Leu Glu Phe Arg Asn Leu Glu Leu Glu 
            580                 585                 590         


Glu Arg Glu Arg Arg Ser Pro Pro Phe Asn Leu Gln Ile His Pro Phe 
        595                 600                 605             


Ser Asp Gly Val Ser Ala Leu Gln Ile Tyr Cys Met Lys Glu Gly Val 
    610                 615                 620                 


Lys Asp Val Asn Ile Pro Asp Leu Ile Lys Gln Leu Asp Ile Leu Gly 
625                 630                 635                 640 


Asp Asn Gly Asn Leu Arg Asn Glu Glu Gln Val Ala Ile Ile Gln Ala 
                645                 650                 655     


Ser Thr Val Leu Ser Leu Ala Glu Lys Trp Ile Gln Gln Ile Glu Gly 
            660                 665                 670         


Ala Glu Ala Ala Leu His Gln Lys Met Met Glu Leu Glu Ser Asp Met 
        675                 680                 685             


Glu Gln Phe Cys Lys Ile Lys Gly Tyr Leu Glu Glu Glu Leu Asp Tyr 
    690                 695                 700                 


Arg Lys Gln Ala Leu Asp Gln Ala Tyr Met Arg Ile Gln Glu Leu Glu 
705                 710                 715                 720 


Ala Thr Leu Tyr Asn Ala Leu Gln Gln Glu Thr Val Ile Lys Phe Gly 
                725                 730                 735     


Glu Leu Leu Ser Glu Lys Gln Gln Glu Glu Leu Arg Thr Ala Val Glu 
            740                 745                 750         


Lys Leu Arg Arg Gln Met Leu Arg Lys Ser Arg Glu Tyr Asp Cys Gln 
        755                 760                 765             


Ile Leu Gln Glu Arg Met Glu Leu Leu Gln Gln Ala His Gln Arg Ile 
    770                 775                 780                 


Arg Asp Leu Glu Asp Lys Thr Asp Ile Gln Lys Arg Gln Ile Lys Asp 
785                 790                 795                 800 


Leu Glu Glu Lys Ser Asn Arg Lys His Gly 
                805                 810 


<210>  1066
<211>  1834
<212>  DNA
<213>  Homo Sapiens

<400>  1066
ggggcttcct tccctctttg taggatggac gaggagtcac tagatgggct gctcttcaaa       60

gaccacgact tctcttctga cttgttgagg cagctcaaca gcttaaggca aagcaggatc      120

ctgactgatg tgagcatctg tgccggtgcc cgggagatcc cctgccaccg caacgtgctg      180

gcctccagca gcccctactt cagggctatg ttctgcagca gcttccggga gaagagtgaa      240

gccaaagtgc agctgaaagg cattgacccc ccaaccctgg accagatcgt ctcctacgtg      300

tatacggggg aggcacatat tgccactgac aatgtcctcc ccgtgatgga ggccgcctcc      360

atgctacagt tccccaagct gtttgaggcc tgctcctcgt acttgcagag ccagttggcc      420

cccagcaact gcctgggtat gatcagactc tcagaaatct taagctgcga gaccctcaag      480

aagaaagcca gggaggtggc actgacgtcc ttcccagagg tggccgcatc ggccgacctg      540

aaggagctct gtgccttgga gttgagggac tatctcggag atgatgggct ctgtggggag      600

gaggaaaagg tgtttgaggc cctcatggtt tggatcaagc atgacctcca ggcccggaag      660

cgatacatgc aggaactgtt caagcaggtc aggctgcagt acatccaccc agccttcttt      720

caccacttca tcgccaacga tgccctcctg cagtcctcgc ctgcatgcca gatcatcttg      780

gagaccgcca agagacagat gttctctttg tgtggcacca ccgtcccaga ctgcaaactc      840

ctgttgcatg tccctccaag aaactcttac caagatttcc tcatcctctt gggcggaagg      900

aaggacagcc agcagaccac cagggacgtc ctactgtaca gcaaacagac cggccaatgg      960

cagagccttg ccaaactccc gacacggctg tacaaggcct ctgccatcac cttgcaccgc     1020

agcatctatg tgctgggggg catggctgtc agctcaggga ggagtctggt cagtcacaat     1080

gtctacatct tctccctgaa actcaatcag tggaggctgg gggagcccat gctggtggcc     1140

cgctactccc acagaagcac tgcccataag aacttcatct tctccatcgg ggggattgga     1200

gaagggcagg agctcatggg ctccatggaa aggtatgaca gcatctgcaa tgtctgggag     1260

agtatggcca gcatgcccgt gggggtgctc caccccgcag tcgctgtgaa agaccaaaga     1320

ctctatctct ttggaggaga ggacatcatg cagaaccctg tgcgccttat ccaggtttat     1380

cacatttcca gaaactcgtg gttcaaaatg gagacaagaa tgatcaagaa cgtgtgtgcc     1440

cctgcagtgg tgcttgggga gcggattgtc attgtgggag gttacacaag gaggattctt     1500

gcttatgacc ctcaatccaa caaatttgtc aaatgtgcgg acatgaaaga ccggaggatg     1560

caccatgggg ccacagtgat gggaaacaaa ctctacgtga cgggcgggcg gcggctgacc     1620

acggactgca acattgagga ctccgcctcc ttcgattgct acgaccccga gacggacacc     1680

tggacatccc agggacagct gccgcacaag ctctttgacc atgcctgcct cactctccag     1740

tgcatacccc gcacgtctgg cctcccatga ggtcgacaag aaaccttctg ccctagtcaa     1800

aatgccttct gtcgccaggg acacaaaccc agct                                 1834


<210>  1067
<211>  581
<212>  PRT
<213>  Homo Sapiens

<400>  1067

Met Asp Glu Glu Ser Leu Asp Gly Leu Leu Phe Lys Asp His Asp Phe 
1               5                   10                  15      


Ser Ser Asp Leu Leu Arg Gln Leu Asn Ser Leu Arg Gln Ser Arg Ile 
            20                  25                  30          


Leu Thr Asp Val Ser Ile Cys Ala Gly Ala Arg Glu Ile Pro Cys His 
        35                  40                  45              


Arg Asn Val Leu Ala Ser Ser Ser Pro Tyr Phe Arg Ala Met Phe Cys 
    50                  55                  60                  


Ser Ser Phe Arg Glu Lys Ser Glu Ala Lys Val Gln Leu Lys Gly Ile 
65                  70                  75                  80  


Asp Pro Pro Thr Leu Asp Gln Ile Val Ser Tyr Val Tyr Thr Gly Glu 
                85                  90                  95      


Ala His Ile Ala Thr Asp Asn Val Leu Pro Val Met Glu Ala Ala Ser 
            100                 105                 110         


Met Leu Gln Phe Pro Lys Leu Phe Glu Ala Cys Ser Ser Tyr Leu Gln 
        115                 120                 125             


Ser Gln Leu Ala Pro Ser Asn Cys Leu Gly Met Ile Arg Leu Ser Glu 
    130                 135                 140                 


Ile Leu Ser Cys Glu Thr Leu Lys Lys Lys Ala Arg Glu Val Ala Leu 
145                 150                 155                 160 


Thr Ser Phe Pro Glu Val Ala Ala Ser Ala Asp Leu Lys Glu Leu Cys 
                165                 170                 175     


Ala Leu Glu Leu Arg Asp Tyr Leu Gly Asp Asp Gly Leu Cys Gly Glu 
            180                 185                 190         


Glu Glu Lys Val Phe Glu Ala Leu Met Val Trp Ile Lys His Asp Leu 
        195                 200                 205             


Gln Ala Arg Lys Arg Tyr Met Gln Glu Leu Phe Lys Gln Val Arg Leu 
    210                 215                 220                 


Gln Tyr Ile His Pro Ala Phe Phe His His Phe Ile Ala Asn Asp Ala 
225                 230                 235                 240 


Leu Leu Gln Ser Ser Pro Ala Cys Gln Ile Ile Leu Glu Thr Ala Lys 
                245                 250                 255     


Arg Gln Met Phe Ser Leu Cys Gly Thr Thr Val Pro Asp Cys Lys Leu 
            260                 265                 270         


Leu Leu His Val Pro Pro Arg Asn Ser Tyr Gln Asp Phe Leu Ile Leu 
        275                 280                 285             


Leu Gly Gly Arg Lys Asp Ser Gln Gln Thr Thr Arg Asp Val Leu Leu 
    290                 295                 300                 


Tyr Ser Lys Gln Thr Gly Gln Trp Gln Ser Leu Ala Lys Leu Pro Thr 
305                 310                 315                 320 


Arg Leu Tyr Lys Ala Ser Ala Ile Thr Leu His Arg Ser Ile Tyr Val 
                325                 330                 335     


Leu Gly Gly Met Ala Val Ser Ser Gly Arg Ser Leu Val Ser His Asn 
            340                 345                 350         


Val Tyr Ile Phe Ser Leu Lys Leu Asn Gln Trp Arg Leu Gly Glu Pro 
        355                 360                 365             


Met Leu Val Ala Arg Tyr Ser His Arg Ser Thr Ala His Lys Asn Phe 
    370                 375                 380                 


Ile Phe Ser Ile Gly Gly Ile Gly Glu Gly Gln Glu Leu Met Gly Ser 
385                 390                 395                 400 


Met Glu Arg Tyr Asp Ser Ile Cys Asn Val Trp Glu Ser Met Ala Ser 
                405                 410                 415     


Met Pro Val Gly Val Leu His Pro Ala Val Ala Val Lys Asp Gln Arg 
            420                 425                 430         


Leu Tyr Leu Phe Gly Gly Glu Asp Ile Met Gln Asn Pro Val Arg Leu 
        435                 440                 445             


Ile Gln Val Tyr His Ile Ser Arg Asn Ser Trp Phe Lys Met Glu Thr 
    450                 455                 460                 


Arg Met Ile Lys Asn Val Cys Ala Pro Ala Val Val Leu Gly Glu Arg 
465                 470                 475                 480 


Ile Val Ile Val Gly Gly Tyr Thr Arg Arg Ile Leu Ala Tyr Asp Pro 
                485                 490                 495     


Gln Ser Asn Lys Phe Val Lys Cys Ala Asp Met Lys Asp Arg Arg Met 
            500                 505                 510         


His His Gly Ala Thr Val Met Gly Asn Lys Leu Tyr Val Thr Gly Gly 
        515                 520                 525             


Arg Arg Leu Thr Thr Asp Cys Asn Ile Glu Asp Ser Ala Ser Phe Asp 
    530                 535                 540                 


Cys Tyr Asp Pro Glu Thr Asp Thr Trp Thr Ser Gln Gly Gln Leu Pro 
545                 550                 555                 560 


His Lys Leu Phe Asp His Ala Cys Leu Thr Leu Gln Cys Ile Pro Arg 
                565                 570                 575     


Thr Ser Gly Leu Pro 
            580     


<210>  1068
<211>  2199
<212>  DNA
<213>  Homo Sapiens

<400>  1068
acgtgatcca cccgcctcgg cctcccaaag tttttggatt acaggtgtga gccacctcgc       60

ccggtcctat ctctctttct tctctttctc cctctcactt tgtttctctt ctctctctct      120

ctcccgcctc cttcccccgt ctcccctccc ttccccccac cgccctcttc atagctgagc      180

ctgtccggca gtgcggcgga tgtacggatg attcagtggc tggcaggaag cccgccctgc      240

ccgcccgcca gtgtcagtgg tgttggcatc agcttgggca ggtgtgcggg ctcaggatgg      300

ggcggccgtg gtgaggaacc ctggactctc agagatggaa tttcaccgtg ttgcctaggc      360

tggtctggag ctcttgatct caagcgatcc tccctgcctc ggcctcccaa cgtgctggga      420

ttataggcgt gagccaccgc tcctggccag ggtctgttcc tagttgcaac agttcttgga      480

aacccactcg agagggccac gcctccattc accaggccac gcatcacaag aggcaacacc      540

aggagccaac atgagctcgg ggactgaact gctgtggccc ggagcagcgc tgctggtgct      600

gttgggggtg gcagccagtc tgtgtgtgcg ctgctcacgc ccaggtgcaa agaggtcaga      660

gaaaatctac cagcagagaa gtctgcgtga ggaccaacag agctttacgg ggtcccggac      720

ctactccttg gtcgggcagg catggccagg acccctggcg gacatggcac ccacaaggaa      780

ggacaagctg ttgcaattct accccagcct ggaggatcca gcatcttcca ggtaccagaa      840

cttcagcaaa ggaagcagac acgggtcgga ggaagcctac atagacccca ttgccatgga      900

gtattacaac tgggggcggt tctcgaagcc cccagaagat gatgatgcca attcctacga      960

gaatgtgctc atttgcaagc agaaaaccac agagacaggt gcccagcagg agggcatagg     1020

tggcctctgc agaggggacc tcagcctgtc actggccctg aagactggcc ccacttctgg     1080

tctctgtccc tctgcctccc cggaagaaga tgaggaatct gaggattatc agaactcagc     1140

atccatccat cagtggcgcg agtccaggaa ggtcatgggg caactccaga gagaagcatc     1200

ccctggcccg gtgggaagcc cagacgagga ggacggggaa ccggattacg tgaatgggga     1260

ggtggcagcc acagaagcct agggcagacc aagaagaaag gagccaaggc aaagagggac     1320

cactgtgctc atggacccat cgctgccttc caaggaccat ttcccagagc tactcaactt     1380

ttaagcccct gccatggttg ctcctggaag gagaaccagc caccctgagg accacctggc     1440

catgcgtgca cagcctggga aaagacagtt actcacggga gctgcaggcc cgtcaccaag     1500

ccctctcccg acccaggctt tgtggggcag gcacctggta ccaagggtaa cccggctcct     1560

ggtatggacg gatgcgcagg atttaggata agctgtcacc cagtccccat aacaaaacca     1620

ctgtccaaca ctggtatctg tgttcttttg tgctatgaat ttggattcct aattgctatt     1680

gttggttgct ggggttttaa atgattgata agcttgtaca gttaacttat agagggggag     1740

ccatatttaa cattctggat ttcagagtag agatttctgt gttgtctcct agaaagcatt     1800

acatgtagtt tatttcagca tccttgttgg gtggggccct ggctctcttc ccctttggtg     1860

ggacctcccc tttctttggg cttcagttca ctcaggaaga aatgaggctg tcgccatctt     1920

tatgtgcttc cagtggaaat gtcacttgct acagacaata gtgcatgaga gtctagagaa     1980

gtagtgacca gaacagggca gagtaggtcc cctccatggc cctgaatcct cctctgctcc     2040

agggctggcc tctgcagagc tgattaaaca gtgttgtgac tgtctcatgg gaagagctgg     2100

ggcccagagg gaccttgagt cagaaatgtt gccagaaaaa gtatctcctc caaccaaaac     2160

atctcaataa aaccatttta gttgaaaagc aaaaaaaaa                            2199


<210>  1069
<211>  243
<212>  PRT
<213>  Homo Sapiens

<400>  1069

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  1070
<211>  2669
<212>  DNA
<213>  Homo Sapiens

<400>  1070
ttcccggtgg ctggctgctc tgattggctg aacaaatagt ccgagggtgg tgggcatccg       60

ccctcccgac aaggcagacc aggccccctg caggtcccct atccgcaccc cggcccctga      120

gagctggcac tgcgactcga gacagcggcc cggcaggaca gctccaggtg agagtgccgg      180

cgccgcggcg ctgccagaat gaaaatgcgg ttcttggggt tggtggtctg tttggttctc      240

tggaccctgc attctgaggg gtctggaggg aaactgacag ctgtggatcc tgaaacaaac      300

atgaatgtga gtgaaattat ctcttactgg ggattcccta gtgaggaata cctagttgag      360

acagaagatg gatatattct gtgccttaac cgaattcctc atgggaggaa gaaccattct      420

gacaaaggtc ccaaaccagt tgtcttcctg caacatggct tgctggcaga ttctagtaac      480

tgggtcacaa accttgccaa cagcagcctg ggcttcattc ttgctgatgc tggttttgac      540

gtgtggatgg gcaacagcag aggaaatacc tggtctcgga aacataagac actctcagtt      600

tctcaggatg aattctgggc tttcagttat gatgagatgg caaaatatga cctaccagct      660

tccattaact tcattctgaa taaaactggc caagaacaag tgtattatgt gggtcattct      720

caaggcacca ctataggttt tatagcattt tcacagatcc ctgagctggc taaaaggatt      780

aaaatgtttt ttgccctggg tcctgtggct tccgtcgcct tctgtactag ccctatggcc      840

aaattaggac gattaccaga tcatctcatt aaggacttat ttggagacaa agaatttctt      900

ccccagagtg cgtttttgaa gtggctgggt acccacgttt gcactcatgt catactgaag      960

gagctctgtg gaaatctctg ttttcttctg tgtggattta atgagagaaa tttaaatatg     1020

tctagagtgg atgtatatac aacacattct cctgctggaa cttctgtgca aaacatgtta     1080

cactggagcc aggctgttaa attccaaaag tttcaagcct ttgactgggg aagcagtgcc     1140

aagaattatt ttcattacaa ccagagttat cctcccacat acaatgtgaa ggacatgctt     1200

gtgccgactg cagtctggag cgggggtcac gactggcttg cagatgtcta cgacgtcaat     1260

atcttactga ctcagatcac caacttggtg ttccatgaga gcattccgga atgggagcat     1320

cttgacttca tttggggcct ggatgcccct tggaggcttt ataataaaat tattaatcta     1380

atgaggaaat atcagtgaaa gctggacttg agctgtgtac caccaagtca atgattatgt     1440

catgtgaaaa tgtgtttgct tcatttctgt aaaacacttg tttttctttc ccaggtcttt     1500

tgttttttta tatccaagaa aatgataact ttgaagatgc ccagttcact ctagtttcaa     1560

ttagaaacat actagctatt ttttctttaa ttagggctgg aataggaagc cagtgtctca     1620

accatagtat tgtctcttta agtcttttaa atatcactga tgtgtaaaaa ggtcattata     1680

tccattctgt ttttaaaatt taaaatatat tgactttttg cccttcatag gacaaagtaa     1740

tatatgtgtt ggaattttaa aattgtgttg tcattggtaa atctgtcact gacttaagcg     1800

aggtataaaa gtacgcagtt ttcatgtcct tgccttaaag agctctctag tctaacggtc     1860

ttgtagttag agatctaaat gacattttat catgttttcc tgcagcaggt gcatagtcaa     1920

atccagaaat atcacagctg tgccagtaat aaggatgcta acaattaatt ttatcaaacc     1980

taactgtgac agctgtgatt tgacacgttt taattgctca ggttaaatga aatagttttc     2040

cggcgtcttc aaaaacaaat tgcactgata aaacaaaaac aaaagtatgt tttaaatgct     2100

ttgaagactg atacactcaa ccatctatat tcatgagctc tcaatttcat ggcaggccat     2160

agttctactt atctgagaag caaatccctg tggagactat accactattt tttctgagat     2220

taatgtactc ttggagcccg ctactgtcgt tattgatcac atctgtgtga agccaaagcc     2280

ccgtggttgc ccatgagaag tgtccttgtt cattttcacc caaatgaagt gtgaacgtga     2340

tgttttcgga tgcaaactca gctcagggat tcattttgtg tcttagtttt atatgcatcc     2400

ttatttttaa tacacctgct tcacgtccct atgttgggaa gtccatattt gtctgctttt     2460

cttgcagcat catttcctta caatactgtc cggtggacaa aatgacaatt gatatgtttt     2520

tctgatataa ttactttagc tgcactaaca gtacaatgct tgttaatggt taatataggc     2580

agggcgaata ctactttgta acttttaaag tcttaaactt ttcaataaaa ttgagtgaga     2640

cttataggcc caaagaaaaa aaaaaaaaa                                       2669


<210>  1071
<211>  399
<212>  PRT
<213>  Homo Sapiens

<400>  1071

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  1072
<211>  2077
<212>  DNA
<213>  Homo Sapiens

<400>  1072
gggaagggga gcttcacagg gggttttctg gaagtgccca gggtgaaact gtgcttgaag       60

gaagctcaga tgtcagtttt tcagattgtg ctgtctgtat atctaggcat tcataaatac      120

tttctagaac tttgtgtagt gttttgcaaa tgtagttaaa cagatttgtg aattcagtaa      180

tttataaaaa cttaagcttg tgttcttctg aatcccttta tttttcttct gcctccgaat      240

tagacacttc ccctatgcat taattccaag tacagtcaaa gattaagtaa ggaaatgatg      300

tgcatgaaaa aagttctgca tgtttgctaa taatctaatg actgtgacat ctaaacactg      360

gaaacacctt gatttatgga taatagggct atctagaatt ttcaagggat catggacaaa      420

taattatagg caatttgatc aagtgaccat gtaagaccat tggtgcagat acagactgat      480

taaagtggaa aaagttcttt tttcttccta gcttcctgct ctgccattac cttgataatg      540

tgagccaagg cctattggcc tccacaggac aagccctagg ctgtagtctg ggcttgcttg      600

aacctgcctg acctgtcact tcaaggccag ccctgatcct ctgagaatgg gcctgggaac      660

catcagaaat tatgtctatt tgcagcaggc agggcctctt ttggtctcca gcatagccct      720

tgccccatct gctcttttca ctttacatgg agtactaggc aaagtggctt cctctttggg      780

ttttgttaca tactttaacc aagactgtgc atgcaaatgg cctggcatgt actcggtgct      840

caggatgttg cagctactga attattatca ttgatttctt ctgcgtgtga cctggatcca      900

caagtcaaat gcaaaaattt gtcttgactg atggtcctct cctgtctccc tccagtaccc      960

cctcttgagg cttgcagggg cagggaccag agggcccagc accatgtcct gctaatgctc     1020

actcctgact gcaagggagt cagggttggg agacgctgta acaggagagg ctacagctga     1080

ctgggatgca gaccgggggc tgggtcctta ggaaatttgt tctaatctta gaaggtatgc     1140

cctggcttcc tgctgcagcc tgaaggacaa gtgtcccaga cctcaggaca cacacgcaca     1200

cgcacactca cactgtcact tgactcctgc ctgggaggca ggaatggccc ctagtgaagg     1260

gtacttgtgt gggcctccag gtggctgtaa cataccccag gactccaggc aatcctggaa     1320

aggtggctcc tggagaccaa ccacccttca gactcagagg agctctctgt gaagtcaatt     1380

ttattattga actaaccaac agtagagagt cagagtagtg cataacaggg agattctgaa     1440

cttaccttgg agagtaacaa atcgtacatt tacttgttgg cttaggtgag taaatccatc     1500

taaatcaccc atgccagcta tgaagagaca cttctttccc actctttccc tttgcaaaag     1560

aaaaaaaaaa aaaaaaccac tcgagctgtt cagaggctgc cagactgaca aggttgagtt     1620

tgatcggcag ctctgcccct gcatgcctgc tggtgggaaa aggaaagaga agacaaaaat     1680

ggttgtgtgt aaccccctga ggcattgctg ccttctgcct cttcatccca gcaccctctc     1740

catctcctct gcagcctttg ctcaccctcc ctgtcttcag cctctgccat caccttgtaa     1800

tttgagccaa gattcaccct caggtttgtc tgactccaca aatcccaagc aggtgcttca     1860

gggtctgccg tgggccctcc actctggcaa ctcacccttt ctgagcactc ctccagtcct     1920

gctcctcccc tcggctcccc ctctctgtaa atgacactcc tctccaccca gaagccagag     1980

ccagaaatct gggcatcatc ttgactccac cctgccccac ccatcagtcc ccaattctgg     2040

tcagtccttc ctcctaaatt gcttttgagt cctatca                              2077


<210>  1073
<211>  147
<212>  PRT
<213>  Homo Sapiens

<400>  1073

Met Pro Ala Met Lys Arg His Phe Phe Pro Thr Leu Ser Leu Cys Lys 
1               5                   10                  15      


Arg Lys Lys Lys Lys Lys Pro Leu Glu Leu Phe Arg Gly Cys Gln Thr 
            20                  25                  30          


Asp Lys Val Glu Phe Asp Arg Gln Leu Cys Pro Cys Met Pro Ala Gly 
        35                  40                  45              


Gly Lys Arg Lys Glu Lys Thr Lys Met Val Val Cys Asn Pro Leu Arg 
    50                  55                  60                  


His Cys Cys Leu Leu Pro Leu His Pro Ser Thr Leu Ser Ile Ser Ser 
65                  70                  75                  80  


Ala Ala Phe Ala His Pro Pro Cys Leu Gln Pro Leu Pro Ser Pro Cys 
                85                  90                  95      


Asn Leu Ser Gln Asp Ser Pro Ser Gly Leu Ser Asp Ser Thr Asn Pro 
            100                 105                 110         


Lys Gln Val Leu Gln Gly Leu Pro Trp Ala Leu His Ser Gly Asn Ser 
        115                 120                 125             


Pro Phe Leu Ser Thr Pro Pro Val Leu Leu Leu Pro Ser Ala Pro Pro 
    130                 135                 140                 


Leu Cys Lys 
145         


<210>  1074
<211>  2711
<212>  RNA
<213>  Homo Sapiens

<400>  1074
ccaacaaaga ggcgcggacg accaagcgcg cacgcaccgg cgcgcacgcg accgccgcaa       60

gccccccgcg cagccacccc gagacgcggc cgagacgggg agggggaagc ccgccggggg      120

gcggcagggc cgggcggccc cggcgcggag gcgcacgggc gcaccggacg ggagcgaccc      180

cgagagagcc cgcgggcagc gcaagcagcg gacggcccga agcccgcgcc gaccccgaca      240

accgacgccg gggccgagga gcagaggacc ggcgaccgcg cggaggcgcg gaccggggca      300

gggccaggag cgcccggaag cccggcgggg gaagggcagg ccccaccggg acagccggcc      360

cccagccaac gacacggcca gggcggcggc gcggcagcag cgggggagaa cgggagggac      420

ccgcggagcg aggaccagga ccggcacaag aggggcgagg aggcaggccc accagccacg      480

ggacccaagg gacgccagaa cacagacgac ccagcacgca ggacgcgggc cgccaacacg      540

acacccccca ccacacgaga cgcaccgcac caccggcgga agcgagacag gggagggccg      600

gacggaggag gaccgaagac ggaggggagg cacaggagaa gagaagacca ccacgcgaca      660

cacaaaagca cccaaggggc agagacagac ccaaaggaga gcgaagggcc ggaaaacggg      720

ccaccccacg ggaagacagg gcaaccgggg ccccacgaag acagggcgcg aagagaccca      780

gagaccggga gcagccaccc cacgggaaag caggcagccc caggcgcacg gcgcagagac      840

agacagaacg cggccgaaga ggaccacgcg gcgcagcacc cacggcagaa caggcaggcc      900

aaggcccccg cccaggaggg gcgcagacag cagcagcagc agcagcagca gcagcagcag      960

cagcagaggc cggcccgagg aagcggccgg gaggaaggaa ggaagcccac caccagacac     1020

ccccagccgg aggaagccca gccagcagca ggaccagcag ggagccagag cccgcaagcg     1080

cagccacacc ccgccagcag cccagcagcc cagcagccag ccacacccac cagggccccg     1140

cccccagccc ccacggccca ggaccgacac accaccccgg gcccaaggag gcaggaggga     1200

acaagccaca gaggaagcaa aaccaaacaa aaaaccaccg acaccggcca agcccccaaa     1260

ccaccccgac ccaaacacgc cgcaccccag acccacgacc gacagaggcc cccacgcagg     1320

cgcagagcag cccagcgcag ggcagaggaa agaaagaagg gaaagggaac aggggagagg     1380

agccagcccg gaaaacccag gaacccagca cggggagagc agggagcccg acacaggggc     1440

ccagaggacc aggggggacc ccagcccccc cgggccccac ccaccacaga gccacgcgga     1500

cagagccagc ggacacagag ccacgcggga caaacaccga aagccccagg gcccagcgcc     1560

gaggaaaaaa ccagccgagg gaaaccgcca ggagccaggg cagcaggacc acagccaccg     1620

gcccacccgc cccaggcccg gacccaagaa cccagagcag agggcacagg ggggagaccg     1680

gagcccaggc aacccgagcg ccaggagaga gccccccacc ggacacccgc ccacgcggag     1740

cgaccagggg cgcacagagc agagacgaga cggcaccgag gagaagggag gcaggcaccc     1800

ggagagggaa gaagagcggc ggcagaggga gcggcccaca cagcccagcc ccccgcgaga     1860

cccccccgga gaagcagagg ccggggagcc caggagggca gaccggggcc gagggagcac     1920

cacaggagga agcaacccaa ggaagacccc aggcggaagg agcagccacc acgggccggg     1980

gagcaagcgg agaaacagca cggccaccca gcccggccaa ggggaaaagc cggaagaccc     2040

aggggggagg aagcgcgccc aaggcccagg acgcgaggcg acggggaaaa cgcaggaccg     2100

cgaagccaca cccgggacca cccagacgcc gccgcacagg agcccccgca ccccaggacc     2160

ccggcacagg ggacagaccc cacggacgca gcacagggac cccaaggggc aggaccaccc     2220

gagcaggaag acaccagaaa agcgcagagc agaccacggg cggacaaaaa ccagaaaaac     2280

gggggagagc cacggaagcc gacagacaac caggcagccc aagacacccc gcggcacgcc     2340

gccgccggag gagccccaag ccaacaaggc cacacggggc cagaaaacac cgggaacgag     2400

ggaccggaag gcagaggacc ccacacccag agcgggagaa gaccacgccc ccaaacagag     2460

caacaacaag acgggccagc agcaccgagc cgacgcccga gcagggaggc ccgcagaagc     2520

acagcgccag gagcaagaag ggagcaccgg gagaagcagg gccccgcaga agcaaggcca     2580

gcccccaccc cacccacagg ggccggagcg caggacccag gggaggggcc ccgcacccaa     2640

gccacagccc ccgcgaccca gaaaccccaa aaaacgcagc cagaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa a                                                          2711


<210>  1075
<211>  3747
<212>  DNA
<213>  Homo Sapiens

<400>  1075
aaatttttcc gtctgccctt tccccctctt ctcgttggca gggttgatcc tcattactgt       60

ttgctcaaac gtttagaagt gaatttaggt ccctcccccc aacttatgat tttatagcca      120

ataggtgatg aggtttattt gcatatttcc agtcacataa gcagccttgg cgtgaaaaca      180

gtgtcagact cgattccccc tcttcctcct cctcaaggga aagctgccca cttctagctg      240

ccctgccatc ccctttaaag ggcgacttgc tcagcgccaa accgcggctc cagccctctc      300

cagcctccgg ctcagccggc tcatcagtcg gtccgcgcct tgcagctcct ccagagggac      360

gcgccccgag atggagagca aagccctgct cgtgctgact ctggccgtgt ggctccagag      420

tctgaccgcc tcccgcggag gggtggccgc cgccgaccaa agaagagatt ttatcgacat      480

cgaaagtaaa tttgccctaa ggacccctga agacacagct gaggacactt gccacctcat      540

tcccggagta gcagagtccg tggctacctg tcatttcaat cacagcagca aaaccttcat      600

ggtgatccat ggctggacgg taacaggaat gtatgagagt tgggtgccaa aacttgtggc      660

cgccctgtac aagagagaac cagactccaa tgtcattgtg gtggactggc tgtcacgggc      720

tcaggagcat tacccagtgt ccgcgggcta caccaaactg gtgggacagg atgtggcccg      780

gtttatcaac tggatggagg aggagtttaa ctaccctctg gacaatgtcc atctcttggg      840

atacagcctt ggagcccatg ctgctggcat tgcaggaagt ctgaccaata agaaagtcaa      900

cagaattact ggcctcgatc cagctggacc taactttgag tatgcagaag ccccgagtcg      960

tctttctcct gatgatgcag attttgtaga cgtcttacac acattcacca gagggtcccc     1020

tggtcgaagc attggaatcc agaaaccagt tgggcatgtt gacatttacc cgaatggagg     1080

tacttttcag ccaggatgta acattggaga agctatccgc gtgattgcag agagaggact     1140

tggagatgtg gaccagctag tgaagtgctc ccacgagcgc tccattcatc tcttcatcga     1200

ctctctgttg aatgaagaaa atccaagtaa ggcctacagg tgcagttcca aggaagcctt     1260

tgagaaaggg ctctgcttga gttgtagaaa gaaccgctgc aacaatctgg gctatgagat     1320

caataaagtc agagccaaaa gaagcagcaa aatgtacctg aagactcgtt ctcagatgcc     1380

ctacaaagtc ttccattacc aagtaaagat tcatttttct gggactgaga gtgaaaccca     1440

taccaatcag gcctttgaga tttctctgta tggcaccgtg gccgagagtg agaacatccc     1500

attcactctg cctgaagttt ccacaaataa gacctactcc ttcctaattt acacagaggt     1560

agatattgga gaactactca tgttgaagct caaatggaag agtgattcat actttagctg     1620

gtcagactgg tggagcagtc ccggcttcgc cattcagaag atcagagtaa aagcaggaga     1680

gactcagaaa aaggtgatct tctgttctag ggagaaagtg tctcatttgc agaaaggaaa     1740

ggcacctgcg gtatttgtga aatgccatga caagtctctg aataagaagt caggctgaaa     1800

ctgggcgaat ctacagaaca aagaacggca tgtgaattct gtgaagaatg aagtggagga     1860

agtaactttt acaaaacata cccagtgttt ggggtgtttc aaaagtggat tttcctgaat     1920

attaatccca gccctaccct tgttagttat tttaggagac agtctcaagc actaaaaagt     1980

ggctaattca atttatgggg tatagtggcc aaatagcaca tcctccaacg ttaaaagaca     2040

gtggatcatg aaaagtgctg ttttgtcctt tgagaaagaa ataattgttt gagcgcagag     2100

taaaataagg ctccttcatg tggcgtattg ggccatagcc tataattggt tagaacctcc     2160

tattttaatt ggaattctgg atctttcgga ctgaggcctt ctcaaacttt actctaagtc     2220

tccaagaata cagaaaatgc ttttccgcgg cacgaatcag actcatctac acagcagtat     2280

gaatgatgtt ttagaatgat tccctcttgc tattggaatg tggtccagac gtcaaccagg     2340

aacatgtaac ttggagaggg acgaagaaag ggtctgataa acacagaggt tttaaacagt     2400

ccctaccatt ggcctgcatc atgacaaagt tacaaattca aggagatata aaatctagat     2460

caattaattc ttaataggct ttatcgttta ttgcttaatc cctctctccc ccttcttttt     2520

tgtctcaaga ttatattata ataatgttct ctgggtaggt gttgaaaatg agcctgtaat     2580

cctcagctga cacataattt gaatggtgca gaaaaaaaaa aagaaaccgt aattttatta     2640

ttagattctc caaatgattt tcatcaattt aaaatcattc aatatctgac agttactctt     2700

cagttttagg cttaccttgg tcatgcttca gttgtacttc cagtgcgtct cttttgttcc     2760

tggctttgac atgaaaagat aggtttgagt tcaaattttg cattgtgtga gcttctacag     2820

attttagaca aggaccgttt ttactaagta aaagggtgga gaggttcctg gggtggattc     2880

ctaagcagtg cttgtaaacc atcgcgtgca atgagccaga tggagtacca tgagggttgc     2940

tatttgttgt ttttaacaac taatcaagag tgagtgaaca actatttata aactagatct     3000

cctatttttc agaatgctct tctacgtata aatatgaaat gataaagatg tcaaatatct     3060

cagaggctat agctgggaac ccgactgtga aagtatgtga tatctgaaca catactagaa     3120

agctctgcat gtgtgttgtc cttcagcata attcggaagg gaaaacagtc gatcaaggga     3180

tgtattggaa catgtcggag tagaaattgt tcctgatgtg ccagaacttc gaccctttct     3240

ctgagagaga tgatcgtgcc tataaatagt aggaccaatg ttgtgattaa catcatcagg     3300

cttggaatga attctctcta aaaataaaat gatgtatgat ttgttgttgg catccccttt     3360

attaattcat taaatttctg gatttgggtt gtgacccagg gtgcattaac ttaaaagatt     3420

cactaaagca gcacatagca ctgggaactc tggctccgaa aaactttgtt atatatatca     3480

aggatgttct ggctttacat tttatttatt agctgtaaat acatgtgtgg atgtgtaaat     3540

ggagcttgta catattggaa aggtcattgt ggctatctgc atttataaat gtgtggtgct     3600

aactgtatgt gtctttatca gtgatggtct cacagagcca actcactctt atgaaatggg     3660

ctttaacaaa acaagaaaga aacgtactta actgtgtgaa gaaatggaat cagcttttaa     3720

taaaattgac aacattttat taccaca                                         3747


<210>  1076
<211>  475
<212>  PRT
<213>  Homo Sapiens

<400>  1076

Met Glu Ser Lys Ala Leu Leu Val Leu Thr Leu Ala Val Trp Leu Gln 
1               5                   10                  15      


Ser Leu Thr Ala Ser Arg Gly Gly Val Ala Ala Ala Asp Gln Arg Arg 
            20                  25                  30          


Asp Phe Ile Asp Ile Glu Ser Lys Phe Ala Leu Arg Thr Pro Glu Asp 
        35                  40                  45              


Thr Ala Glu Asp Thr Cys His Leu Ile Pro Gly Val Ala Glu Ser Val 
    50                  55                  60                  


Ala Thr Cys His Phe Asn His Ser Ser Lys Thr Phe Met Val Ile His 
65                  70                  75                  80  


Gly Trp Thr Val Thr Gly Met Tyr Glu Ser Trp Val Pro Lys Leu Val 
                85                  90                  95      


Ala Ala Leu Tyr Lys Arg Glu Pro Asp Ser Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Leu Ser Arg Ala Gln Glu His Tyr Pro Val Ser Ala Gly Tyr Thr 
        115                 120                 125             


Lys Leu Val Gly Gln Asp Val Ala Arg Phe Ile Asn Trp Met Glu Glu 
    130                 135                 140                 


Glu Phe Asn Tyr Pro Leu Asp Asn Val His Leu Leu Gly Tyr Ser Leu 
145                 150                 155                 160 


Gly Ala His Ala Ala Gly Ile Ala Gly Ser Leu Thr Asn Lys Lys Val 
                165                 170                 175     


Asn Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Asn Phe Glu Tyr Ala 
            180                 185                 190         


Glu Ala Pro Ser Arg Leu Ser Pro Asp Asp Ala Asp Phe Val Asp Val 
        195                 200                 205             


Leu His Thr Phe Thr Arg Gly Ser Pro Gly Arg Ser Ile Gly Ile Gln 
    210                 215                 220                 


Lys Pro Val Gly His Val Asp Ile Tyr Pro Asn Gly Gly Thr Phe Gln 
225                 230                 235                 240 


Pro Gly Cys Asn Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly 
                245                 250                 255     


Leu Gly Asp Val Asp Gln Leu Val Lys Cys Ser His Glu Arg Ser Ile 
            260                 265                 270         


His Leu Phe Ile Asp Ser Leu Leu Asn Glu Glu Asn Pro Ser Lys Ala 
        275                 280                 285             


Tyr Arg Cys Ser Ser Lys Glu Ala Phe Glu Lys Gly Leu Cys Leu Ser 
    290                 295                 300                 


Cys Arg Lys Asn Arg Cys Asn Asn Leu Gly Tyr Glu Ile Asn Lys Val 
305                 310                 315                 320 


Arg Ala Lys Arg Ser Ser Lys Met Tyr Leu Lys Thr Arg Ser Gln Met 
                325                 330                 335     


Pro Tyr Lys Val Phe His Tyr Gln Val Lys Ile His Phe Ser Gly Thr 
            340                 345                 350         


Glu Ser Glu Thr His Thr Asn Gln Ala Phe Glu Ile Ser Leu Tyr Gly 
        355                 360                 365             


Thr Val Ala Glu Ser Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser 
    370                 375                 380                 


Thr Asn Lys Thr Tyr Ser Phe Leu Ile Tyr Thr Glu Val Asp Ile Gly 
385                 390                 395                 400 


Glu Leu Leu Met Leu Lys Leu Lys Trp Lys Ser Asp Ser Tyr Phe Ser 
                405                 410                 415     


Trp Ser Asp Trp Trp Ser Ser Pro Gly Phe Ala Ile Gln Lys Ile Arg 
            420                 425                 430         


Val Lys Ala Gly Glu Thr Gln Lys Lys Val Ile Phe Cys Ser Arg Glu 
        435                 440                 445             


Lys Val Ser His Leu Gln Lys Gly Lys Ala Pro Ala Val Phe Val Lys 
    450                 455                 460                 


Cys His Asp Lys Ser Leu Asn Lys Lys Ser Gly 
465                 470                 475 


<210>  1077
<211>  2486
<212>  DNA
<213>  Homo Sapiens

<400>  1077
gctgtggtaa gtgcatcctc cttcagtctc agttctgaaa atagatcatc atggtggcac       60

caaagagtca cacagatgac tgggctcctg ggcctttctc cagtaagcca cagaggagtc      120

agctgcaaat attctcttct gttctacaga cctctctcct cttcctgctc atgggactaa      180

gagcctctgg aaaggactca gccccaacag tggtgtcagg gatcctaggg ggttccgtga      240

ctctccccct aaacatctca gtagacacag agattgagaa cgtcatctgg attggtccca      300

aaaatgctct tgctttcgca cgtcccaaag aaaatgtaac cattatggtc aaaagctacc      360

tgggccgact agacatcacc aagtggagtt actccctgtg catcagcaat ctgactctga      420

atgatgcagg atcctacaaa gcccagataa accaaaggaa ttttgaagtc accactgagg      480

aggaattcac cctgttcgtc tatgagcagc tgcaggagcc ccaagtcacc atgaagtctg      540

tgaaggtgtc tgagaacttc tcctgtaaca tcactctaat gtgctccgtg aagggggcag      600

agaaaagtgt tctgtacagc tggaccccaa gggaacccca tgcttctgag tccaatggag      660

gctccattct taccgtctcc cgaacaccat gtgacccaga cctgccatac atctgcacag      720

cccagaaccc cgtcagccag agaagctccc tccctgtcca tgttgggcag ttctgtacag      780

atccaggagc ctccagagga ggaacaacgg gggagactgt ggtaggggtc ctgggagagc      840

cagtcaccct gccacttgca ctcccagcct gccgggacac agagaaggtt gtctggttgt      900

ttaacacatc catcattagc aaagagaggg aagaagcagc aacggcagat ccactcatta      960

aatccaggga tccttacaag aacagggtgt gggtctccag ccaggactgc tccctgaaga     1020

tcagccagct gaagatagag gacgccggcc cctaccatgc ctacgtgtgc tcagaggcct     1080

ccagcgtcac cagcatgaca catgtcaccc tgctcatcta ccgcaggctg aggaagccca     1140

aaatcacgtg gagcctcagg cacagtgagg atggcatctg caggatcagc ctgacctgct     1200

ccgtggagga cgggggaaac actgtcatgt acacatggac cccgctgcag aaggaagctg     1260

ttgtgtccca aggggaatca cacctcaatg tctcatggag aagcagtgaa aatcacccca     1320

acctcacatg cacagccagc aaccctgtca gcaggagttc ccaccagttt ctttctgaga     1380

acatctgttc aggacctgag agaaacacaa agctttggat tgggttgttc ctgatggttt     1440

gccttctgtg cgttgggatc ttcagctggt gcatttggaa gcgaaaagga cggtgttcag     1500

tcccagcctt ctgttccagc caagctgagg ccccagcgga tacaccagaa cccacagctg     1560

gccacacgct atactctgtg ctctcccaag gatatgagaa gctggacact cccctcaggc     1620

ctgccaggca acagcctaca cccacctcag acagcagctc tgacagcaac ctcacaactg     1680

aggaggatga ggacaggcct gaggtgcaca agcccatcag tggaagatat gaggtatttg     1740

accaggtcac tcaggagggc gctggacatg acccagcccc tgagggccaa gcagactatg     1800

atcccgtcac tccatatgtc acggaagttg agtctgtggt tggagagaac accatgtatg     1860

cacaagtgtt caacttacag ggaaagaccc cagtttctca gaaggaagag agctcagcca     1920

caatctactg ctccatacgg aaacctcagg tggtgccacc accacaacag aatgatcttg     1980

agattcctga aagtcctacc tatgaaaatt tcacctgaaa ggaaaagcag ctgctgcctc     2040

tctcctggga ccgtggggtt ggaaagtcag ctggacctca tggggcctgg ggctcacaga     2100

cagaagcacc tcagaatttc cttcagtgcc tcagagatgc ctggatgtgg cccctccccc     2160

tccttctcac ccttaaggac tcccaaaccc attaatagtt cagacacagg ctccttcttg     2220

gagcctatgg gcttcagatg tctttgcccc atttgtcacc tcgcacactt atagcgtttc     2280

ctcctcgaaa ttctaccaag actggtcaaa tgttgctgag gggcctggac cagctgtcct     2340

ttacaccacc ttctcaacac tgctgaaaag aacccaagag aattgtcaca catgacacaa     2400

gatgtacata atatcatgct cactgcagtg ttatttaaaa taaaaggcag gaaataaaaa     2460

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          2486


<210>  1078
<211>  655
<212>  PRT
<213>  Homo Sapiens

<400>  1078

Met Val Ala Pro Lys Ser His Thr Asp Asp Trp Ala Pro Gly Pro Phe 
1               5                   10                  15      


Ser Ser Lys Pro Gln Arg Ser Gln Leu Gln Ile Phe Ser Ser Val Leu 
            20                  25                  30          


Gln Thr Ser Leu Leu Phe Leu Leu Met Gly Leu Arg Ala Ser Gly Lys 
        35                  40                  45              


Asp Ser Ala Pro Thr Val Val Ser Gly Ile Leu Gly Gly Ser Val Thr 
    50                  55                  60                  


Leu Pro Leu Asn Ile Ser Val Asp Thr Glu Ile Glu Asn Val Ile Trp 
65                  70                  75                  80  


Ile Gly Pro Lys Asn Ala Leu Ala Phe Ala Arg Pro Lys Glu Asn Val 
                85                  90                  95      


Thr Ile Met Val Lys Ser Tyr Leu Gly Arg Leu Asp Ile Thr Lys Trp 
            100                 105                 110         


Ser Tyr Ser Leu Cys Ile Ser Asn Leu Thr Leu Asn Asp Ala Gly Ser 
        115                 120                 125             


Tyr Lys Ala Gln Ile Asn Gln Arg Asn Phe Glu Val Thr Thr Glu Glu 
    130                 135                 140                 


Glu Phe Thr Leu Phe Val Tyr Glu Gln Leu Gln Glu Pro Gln Val Thr 
145                 150                 155                 160 


Met Lys Ser Val Lys Val Ser Glu Asn Phe Ser Cys Asn Ile Thr Leu 
                165                 170                 175     


Met Cys Ser Val Lys Gly Ala Glu Lys Ser Val Leu Tyr Ser Trp Thr 
            180                 185                 190         


Pro Arg Glu Pro His Ala Ser Glu Ser Asn Gly Gly Ser Ile Leu Thr 
        195                 200                 205             


Val Ser Arg Thr Pro Cys Asp Pro Asp Leu Pro Tyr Ile Cys Thr Ala 
    210                 215                 220                 


Gln Asn Pro Val Ser Gln Arg Ser Ser Leu Pro Val His Val Gly Gln 
225                 230                 235                 240 


Phe Cys Thr Asp Pro Gly Ala Ser Arg Gly Gly Thr Thr Gly Glu Thr 
                245                 250                 255     


Val Val Gly Val Leu Gly Glu Pro Val Thr Leu Pro Leu Ala Leu Pro 
            260                 265                 270         


Ala Cys Arg Asp Thr Glu Lys Val Val Trp Leu Phe Asn Thr Ser Ile 
        275                 280                 285             


Ile Ser Lys Glu Arg Glu Glu Ala Ala Thr Ala Asp Pro Leu Ile Lys 
    290                 295                 300                 


Ser Arg Asp Pro Tyr Lys Asn Arg Val Trp Val Ser Ser Gln Asp Cys 
305                 310                 315                 320 


Ser Leu Lys Ile Ser Gln Leu Lys Ile Glu Asp Ala Gly Pro Tyr His 
                325                 330                 335     


Ala Tyr Val Cys Ser Glu Ala Ser Ser Val Thr Ser Met Thr His Val 
            340                 345                 350         


Thr Leu Leu Ile Tyr Arg Arg Leu Arg Lys Pro Lys Ile Thr Trp Ser 
        355                 360                 365             


Leu Arg His Ser Glu Asp Gly Ile Cys Arg Ile Ser Leu Thr Cys Ser 
    370                 375                 380                 


Val Glu Asp Gly Gly Asn Thr Val Met Tyr Thr Trp Thr Pro Leu Gln 
385                 390                 395                 400 


Lys Glu Ala Val Val Ser Gln Gly Glu Ser His Leu Asn Val Ser Trp 
                405                 410                 415     


Arg Ser Ser Glu Asn His Pro Asn Leu Thr Cys Thr Ala Ser Asn Pro 
            420                 425                 430         


Val Ser Arg Ser Ser His Gln Phe Leu Ser Glu Asn Ile Cys Ser Gly 
        435                 440                 445             


Pro Glu Arg Asn Thr Lys Leu Trp Ile Gly Leu Phe Leu Met Val Cys 
    450                 455                 460                 


Leu Leu Cys Val Gly Ile Phe Ser Trp Cys Ile Trp Lys Arg Lys Gly 
465                 470                 475                 480 


Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala 
                485                 490                 495     


Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser 
            500                 505                 510         


Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln 
        515                 520                 525             


Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu 
    530                 535                 540                 


Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr 
545                 550                 555                 560 


Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala 
                565                 570                 575     


Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu 
            580                 585                 590         


Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn 
        595                 600                 605             


Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr 
    610                 615                 620                 


Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln 
625                 630                 635                 640 


Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr 
                645                 650                 655 


<210>  1079
<211>  6887
<212>  DNA
<213>  Homo Sapiens

<400>  1079
gaggctttaa aatctttttt catcttctag ctgtagctcg ggctgcttgt cggcttggcc       60

tccccctccc ccctttgctc tctgcctcgt ctttccccag gacttcgcta ttttgctttt      120

ttaaaaaaag gcaagaaaga actaaactcc cccctccctc tcctccagtc gggctgcacc      180

tctgccttgc actttgcaca gaggtagaga gcgcgcgagg gagagagagg aaagaaaaaa      240

aataataaag agagccaagc agaagaggag gcgagaagca tgaagtgtta actcccccgt      300

gccaaggccc gcgccgcccg gacagacgcc cgccgcgcct ccagccccga gcggacgccg      360

cgcgcgccct gcctgcagcc cgggccggcg aggcgagccc ttccttatgc aaagcgcgca      420

gcggagcggc gagcggggga cgccgcgcac cgggccgggc tcctccagct tcgccgccgc      480

agccaccacc gccgccaccg cagctcgcgg aggatcttcc cgagcctgaa gccgccggct      540

cggcgcgcaa ggaggcgagc gagcaaggag gggccggggc gagcgaggga gcacattggc      600

gtgagcaggg gggagggagg gcgggcgcgg ggggcgcggg cagggcgggg gggtgtgtgt      660

gtgagcgcgc tcggaggttt cgggccagcc accgccgcgc aagctagaag cgccccagcc      720

cggcaagctg gctcacccgc tggccaccca gcacagcccg ctggcccctc tcctgcagcc      780

catctggcgg agcggcggcg gcggcggcgg cggcggcagg agaatggcat cagaactggc      840

aatgagcaac tccgacctgc ccaccagtcc cctggccatg gaatatgtta atgacttcga      900

tctgatgaag tttgaagtga aaaaggaacc ggtggagacc gaccgcatca tcagccagtg      960

cggccgtctc atcgccgggg gctcgctgtc ctccaccccc atgagcacgc cgtgcagctc     1020

ggtgccccct tcccccagct tctcggcgcc cagcccgggc tcgggcagcg agcagaaggc     1080

gcacctggaa gactactact ggatgaccgg ctacccgcag cagctgaacc ccgaggcgct     1140

gggcttcagc cccgaggacg cggtcgaggc gctcatcagc aacagccacc agctccaggg     1200

cggcttcgat ggctacgcgc gcggggcgca gcagctggcc gcggcggccg gggccggtgc     1260

cggcgcctcc ttgggcggca gcggcgagga gatgggcccc gccgccgccg tggtgtccgc     1320

cgtgatcgcc gcggccgccg cgcagagcgg cgcgggcccg cactaccacc accaccacca     1380

ccacgccgcc ggccaccacc accacccgac ggccggcgcg cccggcgccg cgggcagcgc     1440

ggccgcctcg gccggtggcg ctgggggcgc gggcggcggt ggcccggcca gcgctggggg     1500

cggcggcggc ggcggcggcg gcggaggcgg cgggggcgcg gcgggggcgg ggggcgccct     1560

gcacccgcac cacgccgccg gcggcctgca cttcgacgac cgcttctccg acgagcagct     1620

ggtgaccatg tctgtgcgcg agctgaaccg gcagctgcgc ggggtcagca aggaggaggt     1680

gatccggctg aagcagaaga ggcggaccct gaaaaaccgc ggctatgccc agtcctgccg     1740

cttcaagagg gtgcagcaga gacacgtcct ggagtcggag aagaaccagc tgctgcagca     1800

agtcgaccac ctcaagcagg agatctccag gctggtgcgc gagagggacg cgtacaagga     1860

gaaatacgag aagttggtga gcagcggctt ccgagaaaac ggctcgagca gcgacaaccc     1920

gtcctctccc gagtttttca tgtgagtctg acacgcgatt ccagctagcc accctgataa     1980

gtgctccgcg ggggtccggc tcgggtgtgg gcttgctagt tctagagcca tgctcgccac     2040

cacctcacca cccccacccc caccgagttt ggcccccttg gccccctaca cacacacaaa     2100

cccgcacgca cacaccacac acacacacac acacacacac acaccccaca ccctgctcga     2160

gtttgtggtg gtggtggctg ttttaaactg gggagggaat gggtgtctgg ctcatggatt     2220

gccaatctga aattctccat aacttgctag cttgtttttt tttttttttt acaccccccc     2280

gccccacccc cggacttgca caatgttcaa tgatctcagc agagttcttc atgtgaaacg     2340

ttgatcacct ttgaagcctg catcattcac atattttttc ttcttcttcc ccttcagttc     2400

atgaactggt gttcattttc tgtgtgtgtg tgtgttttat tttgtttgga tttttttttt     2460

taattttact tttagagctt gctgtgttgc ccaccttttt tccaacctcc accctcactc     2520

cttctcaacc catctcttcc gagatgaaag aaaaaaaaaa gcaaagtttt tttttcttct     2580

cctgagttct tcatgtgaga ttgagcttgc aaaggaaaaa aaaatgtgaa atgttataga     2640

cttgcagcgt gccgagttcc atcgggtttt ttttttagca ttgttatgct aaaatagaga     2700

aaaaaatcct catgaacctt ccacaatcaa gcctgcatca accttctggg tgtgacttgt     2760

gagttttggc cttgtgatgc caaatctgag agtttagtct gccattaaaa aaactcattc     2820

tcatctcatg cattattatg cttgctactt tgtcttagca acaatgaact ataactgttt     2880

caaagacttt atggaaaaga gacattatat taataaaaaa aaaaagcctg catgctggac     2940

atgtatggta taattatttt ttcctttttt tttccttttg gcttggaaat ggacgttcga     3000

agacttatag catggcattc atacttttgt tttattgcct catgactttt ttgagtttag     3060

aacaaaacag tgcaaccgta gagccttctt cccatgaaat tttgcatctg ctccaaaact     3120

gctttgagtt actcagaact tcaacctccc aatgcactga aggcattcct tgtcaaagat     3180

accagaatgg gttacacatt taacctggca aacattgaag aactcttaat gttttctttt     3240

taataagaat gacgccccac tttggggact aaaattgtgc tattgccgag aagcagtcta     3300

aaatttattt tttaaaaaga gaaactgccc cattattttt ggtttgtttt atttttattt     3360

tatatttttt ggcttttggt cattgtcaaa tgtggaatgc tctgggtttc tagtatataa     3420

tttaattcta gtttttataa tctgttagcc cagttaaaat gtatgctaca gataaaggaa     3480

tgttatagat aaatttgaaa gagttaggtc tgtttagctg tagatttttt aaacgattga     3540

tgcactaaat tgtttactat tgtgatgtta aggggggtag agtttgcaag gggactgttt     3600

aaaaaaagta gcttatacag catgtgcttg caacttaaat ataagttggg tatgtgtagt     3660

ctttgctata ccactgactg tattgaaaac caaagtatta agaggggaaa cgcccctgtt     3720

tatatctgta ggggtatttt acattcaaaa atgtatgttt ttttttcttt tcaaaattaa     3780

agtatttggg actgaattgc actaagatat aacctgcaag catataatac aaaaaaaaat     3840

tgcaaaactg tttagaacgc taataaaatt tatgcagtta taaaaatggc attactgcac     3900

agttttaaga tgatgcagat ttttttacag ttgtattgtg gtgcagaact ggattttctg     3960

taacttaaaa aaaaatccac agttttaaag gcaataatca gtaaatgtta ttttcaggga     4020

ctgacatcct gtctttaaaa agaaatgaaa agtaaatctt accacaataa atataaaaaa     4080

atcttgtcag ttacttttct tttacatatt ttgctgtgca aaattgtttt atatcttgag     4140

ttactaacta accacgcgtg ttgttcctat gtgcttttct ttcattttca attctggtta     4200

tatcaagaaa agaataatct acaataataa acggcatttt tttttgattc tgtactcagt     4260

ttcttagtgt acagtttaac tgggcccaac aacctcgtta aaagtgtaaa atgcatcctt     4320

ttctccagtg gaaggattcc tggaggaata gggagacagt aattcagggt gaaattatag     4380

gctgtttttt gaagtgagga ggctggcccc atatactgat tagcaatatt taatatagat     4440

gtaaattatg acctcatttt tttctcccca aagttttcag ttttcaaatg agttgagcca     4500

taattgccct tggtaggaaa aacaaaacaa aacagtggaa ctaggcttcc tgagcatggc     4560

cctacacttc tgatcaggag caaagccatc catagacaga ggagccggac aaatatggcg     4620

catcagaggt ggcttgcgca catatgcatt gaacggtaaa gagaaacagc gcttgccttt     4680

tcactaaagt tgactatttt tccttcttct cttacacacc gagattttct tgttagcaag     4740

gcctgacaag atttaacata aacatgacaa atcatagttg tttgttttgt tttgcttttc     4800

tctttaacac tgaagatcat ttgtcttaaa taggaaaaag aaaatccact ccttacttcc     4860

atatttccaa gtacatatct ggtttaaact atgttatcaa atcatatttc accgtgaata     4920

ttcagtggag aacttctcta cctggatgag ctagtaatga tttcagatca tgctatcccc     4980

agaaataaaa gcaaaaaata atacctgtgt ggaatatagg ctgtgctttg atttactggt     5040

atttacccca aaataggctg tgtatggggg ctgacttaaa gatcccttgg aaagactcaa     5100

aactaccttc actagtagga ctcctaagcg ctgacctatt tttaaatgac acaaattcat     5160

gaaactaatg ttacaaattc atgcagtttg cactcttagt catcttcccc tagcacacca     5220

atagaatgtt agacaaagcc agcactgttt tgaaaataca gccaaacacg atgacttttg     5280

ttttgttttc tgccgttctt aaaagaaaaa aagataatat tgcaactctg actgaaagac     5340

ttatttttaa gaaaacaggt tgtgtttggt gctgctaagt tctggccagt ttatcatctg     5400

gccttcctgc ctatttttta caaaacacga agacagtgtg taacctcgac attttgacct     5460

tcctttatgt gctagtttag acaggctcct gaatccacac ttaattttgc ttaacaaaag     5520

tcttaatagt aaacctcccc tcatgagctt gaagtcaagt gttcttgact tcagatattt     5580

ctttcctttt tttttttttt tcctcatcac aactaagaga tacacaaact ctgaagaagc     5640

agaaatggag agaatgcttt taacaaaaaa gcatctgatg aaagatttta ggcaaacatt     5700

ctcaaaataa gagtgatatt ctggatgtag ttattgcagt tatctcatga caaatgaggc     5760

ctggattgga aggaaaatat agttgtgtag aattaagcat tttgatagga atctacaagg     5820

tagttgaata taataagcag gtttgggccc ccaaacttta gaaaatcaaa tgcaaaggtg     5880

ctggcaaaaa tgaggtttga gtggctggct gtaagagaag gttaactcct agtaaaaggc     5940

atttttagaa ataacaatta ctgaaaactt tgaagtatag tgggagtagc aaacaaatac     6000

atgttttttt tttcttacaa agaactccta aatcctgagt aagtgccatt cattacaata     6060

agtctctaaa tttaaaaaaa aaaaaatcat atgaggaaat ctagctttcc cctttacgct     6120

gcgtttgatc tttgtctaaa tagtgttaaa attcctttca ttccaattac agaactgagc     6180

ccactcgcaa gttggagcca tcagtgggat acgccacatt ttggaagccc cagcatcgtg     6240

tacttaccag tgtgttcaca aaatgaaatt tgtgtgagag ctgtacatta aaaaaaatca     6300

tcattattat tattatttgc agtcatggag aaccacctac ccctgacttc tgtttagtct     6360

cctttttaaa taaaaattac tgtgttagag aagaaggcta ttaaatgtag tagttaacta     6420

tgcctcttgt ctgggggttt catagagacc ggtaggaaag cgcactcctg cttttcgatt     6480

tatggtgtgt gcaagtaaac aggtgcattg ctttcaacct gccatactag ttttaaaaat     6540

tcactgaaat tacaaagata catatatatg catatatata atggaaagtt tcccggaatg     6600

caacaattag cattttaaaa tcatatatag gcatgcacat tctaaatagt actttttcat     6660

gcttcattgt ttctctggca gataatttta ctaagaagaa aaatagatat tcgactcccc     6720

ttccctaaac aaatccacgg gcagaggctc cagcggagcc gagccccctg gttttctcgt     6780

aggccctaga cggtgttgca tttatcagtg atgtcaaacg tgctcatttg tcagacatag     6840

ctgtaaatga aaacaatgtg tggcaaaata caaagttaaa aaaaaaa                   6887


<210>  1080
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  1080

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
1               5                   10                  15      


Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
            20                  25                  30          


Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
        35                  40                  45              


Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                85                  90                  95      


Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
            100                 105                 110         


Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
        115                 120                 125             


Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
145                 150                 155                 160 


Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                165                 170                 175     


Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
            180                 185                 190         


His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
        195                 200                 205             


Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                245                 250                 255     


Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
            260                 265                 270         


Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
        275                 280                 285             


Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
    290                 295                 300                 


Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
305                 310                 315                 320 


Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                325                 330                 335     


Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
            340                 345                 350         


Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
        355                 360                 365             


Pro Glu Phe Phe Met 
    370             


<210>  1081
<211>  2163
<212>  DNA
<213>  Homo Sapiens

<400>  1081
gggccggcgg cggcggcggc gcgcggagga gaccgcagtg cggccggcgc taggacccgc       60

gggggcctcc caggccgcgg cgcctcccgc tttcccccac tccccgaccc ttcttcgccc      120

ccaaaatgag gaaacggagc aactcgctcc aagttgtgca gccgggaccg cctcggggtg      180

tgcagccggc tcgcggaggc cctcctgggg gcgggcgcgg ggcgcggctc gggggcgccc      240

cctgagcaga aaacaggaag aaccaggctc ggtccagtgg cacccagctc cctacctcct      300

gtgccagccg actggcctgt ggcaggccat tcccagcgtc cccgactgtg accacttgct      360

cagtgtgcct ctcacctgcc tcagtttccc tctgggggcg atggcggggc gaggctctct      420

ggtttcctgg cgggcatttc acggctgtga ttctgctgag gaacttcccc gggtgagccc      480

ccgcttcctc cgagcctggc acccccctcc cgtctcagcc aggatgccaa cgaggcgctg      540

ggccccgggc acccagtgta tcaccaaatg cgagcacacc cgccccaagc caggggagct      600

ggccttccgc aagggcgacg tggtcaccat cctggaggcc tgcgagaaca agagctggta      660

ccgcgtcaag caccacacca gtggacagga ggggctgctg gcagctgggg cgctgcggga      720

gcgggaggcc ctctccgcag accccaagct cagcctcatg ccgtggttcc acgggaagat      780

ctcgggccag gaggctgtcc agcagctgca gcctcccgag gatgggctgt tcctggtgcg      840

ggagtccgcg cgccaccccg gcgactacgt cctgtgcgtg agctttggcc gcgacgtcat      900

ccactaccgc gtgctgcacc gcgacggcca cctcacaatc gatgaggccg tgttcttctg      960

caacctcatg gacatggtgg agcattacag caaggacaag ggcgctatct gcaccaagct     1020

ggtgagacca aagcggaaac acgggaccaa gtcggccgag gaggagctgg ccagggcggg     1080

ctggttactg aacctgcagc atttgacatt gggagcacag atcggagagg gagagtttgg     1140

agctgtcctg cagggtgagt acctggggca aaaggtggcc gtgaagaata tcaagtgtga     1200

tgtgacagcc caggccttcc tggacgagac ggccgtcatg acgaagatgc aacacgagaa     1260

cctggtgcgt ctcctgggcg tgatcctgca ccaggggctg tacattgtca tggagcacgt     1320

gagcaagggc aacctggtga actttctgcg gacccggggt cgagccctcg tgaacaccgc     1380

tcagctcctg cagttttctc tgcacgtggc cgagggcatg gagtacctgg agagcaagaa     1440

gcttgtgcac cgcgacctgg ccgcccgcaa catcctggtc tcagaggacc tggtggccaa     1500

ggtcagcgac tttggcctgg ccaaagccga gcggaagggg ctagactcaa gccggctgcc     1560

cgtcaagtgg acggcgcccg aggctctcaa acacgggaag ttcaccagca agtcggatgt     1620

ctggagtttt ggggtgctgc tctgggaggt cttctcatat ggacgggctc cgtaccctaa     1680

aatgtcactg aaagaggtgt cggaggccgt ggagaagggg taccgcatgg aaccccccga     1740

gggctgtcca ggccccgtgc acgtcctcat gagcagctgc tgggaggcag agcccgcccg     1800

ccggccaccc ttccgcaaac tggccgagaa gctggcccgg gagctacgca gtgcaggtgc     1860

cccagcctcc gtctcagggc aggacgccga cggctccacc tcgccccgaa gccaggagcc     1920

ctgaccccac ccggtggggc ccttggcccc agaggaccga gagagtggag agtgcggcgt     1980

gggggcactg accaggccca aggagggtcc aggcgggcaa gtcatcctcc tggtgcccac     2040

agcaggggct ggcccacgta gggggctctg ggcggcccgt ggacacccca gacctgcgaa     2100

ggatgatcgc ccgataaaga cggattctaa ggactctaaa aaaaaaaaaa aaaaaaaaaa     2160

aaa                                                                   2163


<210>  1082
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  1082

Met Ala Gly Arg Gly Ser Leu Val Ser Trp Arg Ala Phe His Gly Cys 
1               5                   10                  15      


Asp Ser Ala Glu Glu Leu Pro Arg Val Ser Pro Arg Phe Leu Arg Ala 
            20                  25                  30          


Trp His Pro Pro Pro Val Ser Ala Arg Met Pro Thr Arg Arg Trp Ala 
        35                  40                  45              


Pro Gly Thr Gln Cys Ile Thr Lys Cys Glu His Thr Arg Pro Lys Pro 
    50                  55                  60                  


Gly Glu Leu Ala Phe Arg Lys Gly Asp Val Val Thr Ile Leu Glu Ala 
65                  70                  75                  80  


Cys Glu Asn Lys Ser Trp Tyr Arg Val Lys His His Thr Ser Gly Gln 
                85                  90                  95      


Glu Gly Leu Leu Ala Ala Gly Ala Leu Arg Glu Arg Glu Ala Leu Ser 
            100                 105                 110         


Ala Asp Pro Lys Leu Ser Leu Met Pro Trp Phe His Gly Lys Ile Ser 
        115                 120                 125             


Gly Gln Glu Ala Val Gln Gln Leu Gln Pro Pro Glu Asp Gly Leu Phe 
    130                 135                 140                 


Leu Val Arg Glu Ser Ala Arg His Pro Gly Asp Tyr Val Leu Cys Val 
145                 150                 155                 160 


Ser Phe Gly Arg Asp Val Ile His Tyr Arg Val Leu His Arg Asp Gly 
                165                 170                 175     


His Leu Thr Ile Asp Glu Ala Val Phe Phe Cys Asn Leu Met Asp Met 
            180                 185                 190         


Val Glu His Tyr Ser Lys Asp Lys Gly Ala Ile Cys Thr Lys Leu Val 
        195                 200                 205             


Arg Pro Lys Arg Lys His Gly Thr Lys Ser Ala Glu Glu Glu Leu Ala 
    210                 215                 220                 


Arg Ala Gly Trp Leu Leu Asn Leu Gln His Leu Thr Leu Gly Ala Gln 
225                 230                 235                 240 


Ile Gly Glu Gly Glu Phe Gly Ala Val Leu Gln Gly Glu Tyr Leu Gly 
                245                 250                 255     


Gln Lys Val Ala Val Lys Asn Ile Lys Cys Asp Val Thr Ala Gln Ala 
            260                 265                 270         


Phe Leu Asp Glu Thr Ala Val Met Thr Lys Met Gln His Glu Asn Leu 
        275                 280                 285             


Val Arg Leu Leu Gly Val Ile Leu His Gln Gly Leu Tyr Ile Val Met 
    290                 295                 300                 


Glu His Val Ser Lys Gly Asn Leu Val Asn Phe Leu Arg Thr Arg Gly 
305                 310                 315                 320 


Arg Ala Leu Val Asn Thr Ala Gln Leu Leu Gln Phe Ser Leu His Val 
                325                 330                 335     


Ala Glu Gly Met Glu Tyr Leu Glu Ser Lys Lys Leu Val His Arg Asp 
            340                 345                 350         


Leu Ala Ala Arg Asn Ile Leu Val Ser Glu Asp Leu Val Ala Lys Val 
        355                 360                 365             


Ser Asp Phe Gly Leu Ala Lys Ala Glu Arg Lys Gly Leu Asp Ser Ser 
    370                 375                 380                 


Arg Leu Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Lys His Gly Lys 
385                 390                 395                 400 


Phe Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu 
                405                 410                 415     


Val Phe Ser Tyr Gly Arg Ala Pro Tyr Pro Lys Met Ser Leu Lys Glu 
            420                 425                 430         


Val Ser Glu Ala Val Glu Lys Gly Tyr Arg Met Glu Pro Pro Glu Gly 
        435                 440                 445             


Cys Pro Gly Pro Val His Val Leu Met Ser Ser Cys Trp Glu Ala Glu 
    450                 455                 460                 


Pro Ala Arg Arg Pro Pro Phe Arg Lys Leu Ala Glu Lys Leu Ala Arg 
465                 470                 475                 480 


Glu Leu Arg Ser Ala Gly Ala Pro Ala Ser Val Ser Gly Gln Asp Ala 
                485                 490                 495     


Asp Gly Ser Thr Ser Pro Arg Ser Gln Glu Pro 
            500                 505         


<210>  1083
<211>  1814
<212>  DNA
<213>  Homo Sapiens

<400>  1083
attctcagca cagcctttaa ggttccaaac atctgctaga agaggaatgc agatttaaac       60

tgagtgaggt gtggagtggg ggaagttgat tgggtctaga ccaaagaact ttgaggaact      120

tgcccagagc cctgcatgca tcagacctac agcagacatt gcaggcctga agaaaggtgg      180

tcacaagagg ggtggaacat tcctgcaaat ggtttcaata tatgcagatg tctcaatata      240

ggaatgaaat tacgtctttg gaacaactta aataagtcaa atatacttgg agctttaaaa      300

attaaaagga gagagattcg agcacctttt ctgctgccat gacaaccatg caaggaatgg      360

aacaggccat gccaggggct ggccctggtg tgccccagct gggaaacatg gctgtcatac      420

attcacatct gtggaaagga ttgcaagaga agttcttgaa gggagaaccc aaagtccttg      480

gggttgtgca gattctgact gccctgatga gccttagcat gggaataaca atgatgtgta      540

tggcatctaa tacttatgga agtaacccta tttccgtgta tatcgggtac acaatttggg      600

ggtcagtaat gtttattatt tcaggatcct tgtcaattgc agcaggaatt agaactacaa      660

aaggcctggt ccgaggtagt ctaggaatga atatcaccag ctctgtactg gctgcatcag      720

ggatcttaat caacacattt agcttggcgt tttattcatt ccatcaccct tactgtaact      780

actatggcaa ctcaaataat tgtcatggga ctatgtccat cttaatgggt ctggatggca      840

tggtgctcct cttaagtgtg ctggaattct gcattgctgt gtccctctct gcctttggat      900

gtaaagtgct ctgttgtacc cctggtgggg ttgtgttaat tctgccatca cattctcaca      960

tggcagaaac agcatctccc acaccactta atgaggtttg aggccaccaa aagatcaaca     1020

gacaaatgct ccagaaatct atgctgactg tgacacaaga gcctcacatg agaaattacc     1080

agtatccaac ttcgatactg atagacttgt tgatattatt attatatgta atccaattat     1140

gaactgtgtg tgtatagaga gataataaat tcaaaattat gttctcattt ttttccctgg     1200

aactcaataa ctcatttcac tggctcttta tcgagagtac tagaagttaa attaataaat     1260

aatgcattta atgaggcaac agcacttgaa agtttttcat tcatcataag aactttatat     1320

aaaggcatta cattggcaaa taaggtttgg aagcagaaga gcaaaaaaaa gatattgtta     1380

aaatgaggcc tccatgcaaa acacatactt ccctcccatt tatttaactt tttttttctc     1440

ctacctatgg ggaccaaagt gctttttcct tcaggaagtg gagatgcatg gccatctccc     1500

cctccctttt tccttctcct gcttttcttt ccccatagaa agtaccttga agtagcacag     1560

tccgtccttg catgtgcacg agctatcatt tgagtaaaag tatacatgga gtaaaaatca     1620

tattaagcat cagattcaac ttatattttc tatttcatct tcttcctttc ccttctccca     1680

ccttctactg ggcataatta tatcttaatc atatatggaa atgtgcaaca tatggtattt     1740

gttaaatacg tttgttttta ttgcagagca aaaataaatc aaattagaag caataaaaaa     1800

aaaaaaaaaa aaaa                                                       1814


<210>  1084
<211>  220
<212>  PRT
<213>  Homo Sapiens

<400>  1084

Met Thr Thr Met Gln Gly Met Glu Gln Ala Met Pro Gly Ala Gly Pro 
1               5                   10                  15      


Gly Val Pro Gln Leu Gly Asn Met Ala Val Ile His Ser His Leu Trp 
            20                  25                  30          


Lys Gly Leu Gln Glu Lys Phe Leu Lys Gly Glu Pro Lys Val Leu Gly 
        35                  40                  45              


Val Val Gln Ile Leu Thr Ala Leu Met Ser Leu Ser Met Gly Ile Thr 
    50                  55                  60                  


Met Met Cys Met Ala Ser Asn Thr Tyr Gly Ser Asn Pro Ile Ser Val 
65                  70                  75                  80  


Tyr Ile Gly Tyr Thr Ile Trp Gly Ser Val Met Phe Ile Ile Ser Gly 
                85                  90                  95      


Ser Leu Ser Ile Ala Ala Gly Ile Arg Thr Thr Lys Gly Leu Val Arg 
            100                 105                 110         


Gly Ser Leu Gly Met Asn Ile Thr Ser Ser Val Leu Ala Ala Ser Gly 
        115                 120                 125             


Ile Leu Ile Asn Thr Phe Ser Leu Ala Phe Tyr Ser Phe His His Pro 
    130                 135                 140                 


Tyr Cys Asn Tyr Tyr Gly Asn Ser Asn Asn Cys His Gly Thr Met Ser 
145                 150                 155                 160 


Ile Leu Met Gly Leu Asp Gly Met Val Leu Leu Leu Ser Val Leu Glu 
                165                 170                 175     


Phe Cys Ile Ala Val Ser Leu Ser Ala Phe Gly Cys Lys Val Leu Cys 
            180                 185                 190         


Cys Thr Pro Gly Gly Val Val Leu Ile Leu Pro Ser His Ser His Met 
        195                 200                 205             


Ala Glu Thr Ala Ser Pro Thr Pro Leu Asn Glu Val 
    210                 215                 220 


<210>  1085
<211>  2961
<212>  DNA
<213>  Homo Sapiens

<400>  1085
aagagatgat ttctccatcc tgaacgtgca gcgagcttgt caggaagatc ggaggtgcca       60

agtagcagag aaagcatccc ccagctctga cagggagaca gcacatgtct aaggcccaca      120

agccttggcc ctaccggagg agaagtcaat tttcttctcg aaaatacctg aaaaaagaaa      180

tgaattcctt ccagcaacag ccaccgccat tcggcacagt gccaccacaa atgatgtttc      240

ctccaaactg gcagggggca gagaaggacg ctgctttcct cgccaaggac ttcaactttc      300

tcactttgaa caatcagcca ccaccaggaa acaggagcca accaagggca atggggcccg      360

agaacaacct gtacagccag tacgagcaga aggtgcgccc ctgcattgac ctcatcgact      420

ccctgcgggc tctgggtgtg gagcaggacc tggccctgcc agccatcgcc gtcatcgggg      480

accagagctc gggcaagagc tctgtgctgg aggcactgtc aggagtcgcg cttcccagag      540

gcagcggaat cgtaaccagg tgtccgctgg tgctgaaact gaaaaagcag ccctgtgagg      600

catgggccgg aaggatcagc taccggaaca ccgagctaga gcttcaggac cctggccagg      660

tggagaaaga gatacacaaa gcccagaacg tcatggccgg gaatggccgg ggcatcagcc      720

atgagctcat cagcctggag atcacctccc ctgaggttcc agacctgacc atcattgacc      780

ttcccggcat caccagggtg gctgtggaca accagccccg agacatcgga ctgcagatca      840

aggctctcat caagaagtac atccagaggc agcagacgat caacttggtg gtggttccct      900

gtaacgtgga cattgccacc acggaggcgc tgagcatggc ccatgaggtg gacccggaag      960

gggacaggac catcggtatc ctgaccaaac cagatctaat ggacaggggc actgagaaaa     1020

gcgtcatgaa tgtggtgcgg aacctcacgt accccctcaa gaagggctac atgattgtga     1080

agtgccgggg ccagcaggag atcacaaaca ggctgagctt ggcagaggca accaagaaag     1140

aaattacatt ctttcaaaca catccatatt tcagagttct cctggaggag gggtcagcca     1200

cggttccccg actggcagaa agacttacca ctgaactcat catgcatatc caaaaatcgc     1260

tcccgttgtt agaaggacaa ataagggaga gccaccagaa ggcgaccgag gagctgcggc     1320

gttgcggggc tgacatcccc agccaggagg ccgacaagat gttctttcta attgagaaaa     1380

tcaagatgtt taatcaggac atcgaaaagt tagtagaagg agaagaagtt gtaagggaga     1440

atgagacccg tttatacaac aaaatcagag aggattttaa aaactgggta ggcatacttg     1500

caactaatac ccaaaaagtt aaaaatatta tccacgaaga agttgaaaaa tatgaaaagc     1560

agtatcgagg caaggagctt ctgggatttg tcaactacaa gacatttgag atcatcgtgc     1620

atcagtacat ccagcagctg gtggagcccg cccttagcat gctccagaaa gccatggaaa     1680

ttatccagca agctttcatt aacgtggcca aaaaacattt tggcgaattt ttcaacctta     1740

accaaactgt tcagagcacg attgaagaca taaaagtgaa acacacagca aaggcagaaa     1800

acatgatcca acttcagttc agaatggagc agatggtttt ttgtcaagat cagatttaca     1860

gtgttgttct gaagaaagtc cgagaagaga tttttaaccc tctggggacg ccttcacaga     1920

atatgaagtt gaactctcat tttcccagta atgagtcttc ggtttcctcc tttactgaaa     1980

taggcatcca cctgaatgcc tacttcttgg aaaccagcaa acgtctcgcc aaccagatcc     2040

catttataat tcagtatttt atgctccgag agaatggtga ctccttgcag aaagccatga     2100

tgcagatact acaggaaaaa aatcgctatt cctggctgct tcaagagcag agtgagaccg     2160

ctaccaagag aagaatcctt aaggagagaa tttaccggct cactcaggcg cgacacgcac     2220

tctgtcaatt ctccagcaaa gagatccact gaagggcggc gatgcctgtg gttgttttct     2280

tgtgcgtact cattcattct aaggggagtc ggtgcaggat gccgcttctg ctttggggcc     2340

aaactcttct gtcactatca gtgtccatct ctactgtact ccctcagcat cagagcatgc     2400

atcaggggtc cacacaggct cagctctctc caccacccag ctcttccctg accttcacga     2460

agggatggct ctccagtcct tgggtcccgt agcacacagt tacagtgtcc taagatactg     2520

ctatcattct tcgctaattt gtatttgtat tcccttcccc ctacaagatt atgagacccc     2580

agagggggaa ggtctgggtc aaattcttct tttgtatgtc cagtctcctg cacagcacct     2640

gcagcattgt aactgcttaa taaatgacat ctcactgaac gaatgagtgc tgtgtaagtg     2700

atggagatac ctgaggctat tgctcaagcc caggccttgg acatttagtg actgttagcc     2760

ggtccctttc agatccagtg gccatgcccc ctgcttccca tggttcactg tcattgtgtt     2820

tcccagcctc tccactcccc cgccagaaag gagcctgagt gattctcttt tcttcttgtt     2880

tccctgatta tgatgagctt ccattgttct gttaagtctt gaagaggaat ttaataaagc     2940

aaagaaactt tttaaaaacg t                                               2961


<210>  1086
<211>  715
<212>  PRT
<213>  Homo Sapiens

<400>  1086

Met Ser Lys Ala His Lys Pro Trp Pro Tyr Arg Arg Arg Ser Gln Phe 
1               5                   10                  15      


Ser Ser Arg Lys Tyr Leu Lys Lys Glu Met Asn Ser Phe Gln Gln Gln 
            20                  25                  30          


Pro Pro Pro Phe Gly Thr Val Pro Pro Gln Met Met Phe Pro Pro Asn 
        35                  40                  45              


Trp Gln Gly Ala Glu Lys Asp Ala Ala Phe Leu Ala Lys Asp Phe Asn 
    50                  55                  60                  


Phe Leu Thr Leu Asn Asn Gln Pro Pro Pro Gly Asn Arg Ser Gln Pro 
65                  70                  75                  80  


Arg Ala Met Gly Pro Glu Asn Asn Leu Tyr Ser Gln Tyr Glu Gln Lys 
                85                  90                  95      


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
            100                 105                 110         


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
        115                 120                 125             


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
    130                 135                 140                 


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
145                 150                 155                 160 


Lys Gln Pro Cys Glu Ala Trp Ala Gly Arg Ile Ser Tyr Arg Asn Thr 
                165                 170                 175     


Glu Leu Glu Leu Gln Asp Pro Gly Gln Val Glu Lys Glu Ile His Lys 
            180                 185                 190         


Ala Gln Asn Val Met Ala Gly Asn Gly Arg Gly Ile Ser His Glu Leu 
        195                 200                 205             


Ile Ser Leu Glu Ile Thr Ser Pro Glu Val Pro Asp Leu Thr Ile Ile 
    210                 215                 220                 


Asp Leu Pro Gly Ile Thr Arg Val Ala Val Asp Asn Gln Pro Arg Asp 
225                 230                 235                 240 


Ile Gly Leu Gln Ile Lys Ala Leu Ile Lys Lys Tyr Ile Gln Arg Gln 
                245                 250                 255     


Gln Thr Ile Asn Leu Val Val Val Pro Cys Asn Val Asp Ile Ala Thr 
            260                 265                 270         


Thr Glu Ala Leu Ser Met Ala His Glu Val Asp Pro Glu Gly Asp Arg 
        275                 280                 285             


Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Met Asp Arg Gly Thr Glu 
    290                 295                 300                 


Lys Ser Val Met Asn Val Val Arg Asn Leu Thr Tyr Pro Leu Lys Lys 
305                 310                 315                 320 


Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Thr Asn Arg 
                325                 330                 335     


Leu Ser Leu Ala Glu Ala Thr Lys Lys Glu Ile Thr Phe Phe Gln Thr 
            340                 345                 350         


His Pro Tyr Phe Arg Val Leu Leu Glu Glu Gly Ser Ala Thr Val Pro 
        355                 360                 365             


Arg Leu Ala Glu Arg Leu Thr Thr Glu Leu Ile Met His Ile Gln Lys 
    370                 375                 380                 


Ser Leu Pro Leu Leu Glu Gly Gln Ile Arg Glu Ser His Gln Lys Ala 
385                 390                 395                 400 


Thr Glu Glu Leu Arg Arg Cys Gly Ala Asp Ile Pro Ser Gln Glu Ala 
                405                 410                 415     


Asp Lys Met Phe Phe Leu Ile Glu Lys Ile Lys Met Phe Asn Gln Asp 
            420                 425                 430         


Ile Glu Lys Leu Val Glu Gly Glu Glu Val Val Arg Glu Asn Glu Thr 
        435                 440                 445             


Arg Leu Tyr Asn Lys Ile Arg Glu Asp Phe Lys Asn Trp Val Gly Ile 
    450                 455                 460                 


Leu Ala Thr Asn Thr Gln Lys Val Lys Asn Ile Ile His Glu Glu Val 
465                 470                 475                 480 


Glu Lys Tyr Glu Lys Gln Tyr Arg Gly Lys Glu Leu Leu Gly Phe Val 
                485                 490                 495     


Asn Tyr Lys Thr Phe Glu Ile Ile Val His Gln Tyr Ile Gln Gln Leu 
            500                 505                 510         


Val Glu Pro Ala Leu Ser Met Leu Gln Lys Ala Met Glu Ile Ile Gln 
        515                 520                 525             


Gln Ala Phe Ile Asn Val Ala Lys Lys His Phe Gly Glu Phe Phe Asn 
    530                 535                 540                 


Leu Asn Gln Thr Val Gln Ser Thr Ile Glu Asp Ile Lys Val Lys His 
545                 550                 555                 560 


Thr Ala Lys Ala Glu Asn Met Ile Gln Leu Gln Phe Arg Met Glu Gln 
                565                 570                 575     


Met Val Phe Cys Gln Asp Gln Ile Tyr Ser Val Val Leu Lys Lys Val 
            580                 585                 590         


Arg Glu Glu Ile Phe Asn Pro Leu Gly Thr Pro Ser Gln Asn Met Lys 
        595                 600                 605             


Leu Asn Ser His Phe Pro Ser Asn Glu Ser Ser Val Ser Ser Phe Thr 
    610                 615                 620                 


Glu Ile Gly Ile His Leu Asn Ala Tyr Phe Leu Glu Thr Ser Lys Arg 
625                 630                 635                 640 


Leu Ala Asn Gln Ile Pro Phe Ile Ile Gln Tyr Phe Met Leu Arg Glu 
                645                 650                 655     


Asn Gly Asp Ser Leu Gln Lys Ala Met Met Gln Ile Leu Gln Glu Lys 
            660                 665                 670         


Asn Arg Tyr Ser Trp Leu Leu Gln Glu Gln Ser Glu Thr Ala Thr Lys 
        675                 680                 685             


Arg Arg Ile Leu Lys Glu Arg Ile Tyr Arg Leu Thr Gln Ala Arg His 
    690                 695                 700                 


Ala Leu Cys Gln Phe Ser Ser Lys Glu Ile His 
705                 710                 715 


<210>  1087
<211>  3760
<212>  DNA
<213>  Homo Sapiens

<400>  1087
gacggtgctg tccaggggga ggcgggcgga gggaaggcgc tgccgctgct gccgccgcct       60

cgcccgaagc gacacagacg ctgggagcgg ccgaggcgag atcctatcat tattttaaaa      120

ttcctcctcc tccacgaagt ccttcctgat tccttcaaag aaatatcact cctccgaatt      180

cccagagtga tttcttctga cttgagcctg cagtgtgctg tgagagatct accactagat      240

tatctcaact ttggtctcct gggaccactc gttgctgaca gtcagaaatt gcagggcatc      300

tgatctcctg gtgttaaaat ctgtcgtgat accgaggaag gccccgagat cccaggcact      360

gagtgactgc atactctgaa ttcttgccgc caggatgggg aaacagaaca gcaagctgcg      420

cccggaggtc atgcaggact tgctggaaag cacagacttt acagagcatg agatccagga      480

atggtataaa ggcttcttga gagactgccc cagtggacat ttgtcaatgg aagagtttaa      540

gaaaatatat gggaactttt tcccttatgg ggatgcttcc aaatttgcag agcatgtctt      600

ccgcaccttc gatgcaaatg gagatgggac aatagacttt agagaattca tcatcgcctt      660

gagtgtaact tcgaggggga agctggagca gaagctgaaa tgggccttca gcatgtacga      720

cctggacgga aatggctata tcagcaaggc agagatgcta gagatcgtgc aggcaatcta      780

taagatggtt tcctctgtaa tgaaaatgcc tgaagatgag tcaaccccag agaaaagaac      840

agaaaagatc ttccgccaga tggacaccaa tagagacgga aaactctccc tggaagagtt      900

catccgagga gccaaaagcg acccgtccat tgtgcgcctc ctgcagtgcg acccgagcag      960

tgccggccag ttctgagccc tgcgcccacc aatcgaattg tagagctgct tgtgttccct     1020

tttgattctt ctttttaaca attttttttt ttttttgcca aacaatatca atggtgatgc     1080

cgtcccctgt gcggtctgat gcgccttcct ccgtgacgcc ttcagcttct tttgtcgtgg     1140

atgcttcgtg ggaatgccca gagccccagt gtgcttgtgg agagcatgga cagacttcgt     1200

ggtgttcatt gtttgatgat ttttaatcgt tactattatt tttttttatt ctaatgtctc     1260

tgttctaaaa cgtaagactc gggggttggg gcaaaagaag ggaaacccat ccagtcctgt     1320

gattctattg caagcttcaa ggggcttttg tttgaaagac aaaactcccc acctgaatct     1380

gttgtcacac gtgccgtagg ggtgatggat ggcaccggat gctggattcc ccaagaacaa     1440

gttaccctct ggggtgaggc tattccagcg agctgggaca tttccccatg ggggcccact     1500

cccctctctt ccccagcagg ctgtagtttc taagctgtga acatttcaag ataaattaac     1560

agaggagagg aaaaagatgg ctcagctatt ttttcacagg tttacactag ttgagctaat     1620

atgcgtgtct ttggaaatta aacacaaatg gtaacatatt ccaaaaccag acccatcttg     1680

ttgcctattg tgataaaata aaaagacggc tgtatataac atattgggta atgcagacca     1740

aattaagtgt tttgccttgt ttaaatgaaa tgcatgttta gtgagcacta atacaatctt     1800

attccagaag actgttttta gtagcttatt gtgaagtaag acaactataa tgaatgtctg     1860

tcttgtttgg aagtcatatc tgtctttgca caaatgtacc aatcgacaag tatattttat     1920

atattccata aaaatacaaa gtaaccctga ctagggccca actttaattt tgaatgcatt     1980

tccagagtgg ccatgcctag agggcagatg cagagcaggt ggtagtggga caggacaatt     2040

ggagcacagg aatgttaaca tgtatgacag gggaccagta gggtggtttc cctctcaggc     2100

ccagcagccc attgacagca ttagactggc ggcatggtgc ttttctgagc agatcaatac     2160

tctgcagact cgaaaaaaca tcacatacat tcttggaact tcccagtggt ttaatctatg     2220

tgcatggtta gggagccagg tctggaatat tcagtttccc tgcccctgtt aaagaatcag     2280

aggttgggca gtcatcaaat tcatcataaa gacatgggca agtgtgtctg tggtttccaa     2340

ggccccccta tggagaatcc aaaagtattt tccattgccg tgctctttga atgcagactt     2400

ctatttccag aagtgacagc acaagtctga gttgctgttt ggtctggtga cctcagacac     2460

actaatttga attgaaagct aagagtaaaa atttgctggt tacaggcgag tcatactctt     2520

gcaagtagtt agcaaaggga ggcccaaatt ctcaaggttg ttgatgggga acttgccact     2580

aagagaaggc agagaggtcc ctagtgggta tatttgctgc caagccactt gccaaagaag     2640

aggaaccaca gaaagagaga catcatgacc aggagaaaaa tgtgactaga catgctaacc     2700

tccaggtttt tatatatgac ttgagtctgc tgtaattggc agcagaaatc caaatttgta     2760

tggtagacca aaaagaacca aatccatagg gtgaaatttt gagacctaga ctctgtaaaa     2820

ataatcctag tcttcctcca ggggtcagtt cctcacagtg gttctgtacc aaaacttgcc     2880

aaattcctcc atggccaagt gttaaaatct gtgtttggaa aatagcgaat taacctaaga     2940

cacagaaggc agactgggtg aggagaccta gcatgcccta ttggcagtgc tcaggagctg     3000

catcccactt ttccctgctc tgaatcgaag tcctagttcc ttcctttgat tctcctttgg     3060

taggtggaat cagttaatgt tttgagaaac ctgcctgggc tctgccctta gtcatgacat     3120

ctcgctgagc cagacccact ctgttccttg gaacctagag ctggagtgag gagtagaggt     3180

ctccggctat tccagaaaga aaagtgagcc acatgcaggc tgatgaatgc cgacacttcc     3240

agaatgtata gaaatagtcc ctgtcctggc ctgccactga ccctgtctgt attttctcgg     3300

aggttgtttt tctccttctc cttcccagga aggtctttgt atgtcgaatc cagtgcactc     3360

aagtttggcc aagggactcc acagcaccca gaagactgca tgcctcaagg tttatgtcac     3420

tcctctgctg ggctgttcat tgtcattgct gtgttcaggg acctttggaa ataaaacctg     3480

ttctgtccca aataaaacca gcctgtgatg ttcaagggac tggaataaag tggcttacga     3540

cctgaaggat tctacagagt gctcaactgt tcatacatca ttcagagtgg gagggagctg     3600

ggggtgctgt cccatcccat ctgtatgccc acggtggatt taataatata taatttataa     3660

atcatagcct atggagtggc ccgtaaatca gttgactgtg tagctcttgc ctggcattaa     3720

agcatgtttt tggtttaaca tgaaaaaaaa aaaaaaaaaa                           3760


<210>  1088
<211>  193
<212>  PRT
<213>  Homo Sapiens

<400>  1088

Met Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Met Gln Asp Leu 
1               5                   10                  15      


Leu Glu Ser Thr Asp Phe Thr Glu His Glu Ile Gln Glu Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Arg Asp Cys Pro Ser Gly His Leu Ser Met Glu Glu Phe 
        35                  40                  45              


Lys Lys Ile Tyr Gly Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Glu His Val Phe Arg Thr Phe Asp Ala Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys 
                85                  90                  95      


Leu Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asn Gly Tyr Ile Ser Lys Ala Glu Met Leu Glu Ile Val Gln Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr 
    130                 135                 140                 


Pro Glu Lys Arg Thr Glu Lys Ile Phe Arg Gln Met Asp Thr Asn Arg 
145                 150                 155                 160 


Asp Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp 
                165                 170                 175     


Pro Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Gly Gln 
            180                 185                 190         


Phe 
    


<210>  1089
<211>  3866
<212>  DNA
<213>  Homo Sapiens

<400>  1089
cagtcgctgt ttgggacgct gggtgtgcgg tgttctgtct ccgctcccgt ttcgctgtca       60

cagcccgttc cttcccggag cccgggacag gctgggcgcg cgcccgtgtg agtgagcggg      120

actcagggca gaagtgtccc ctcactgcgt ttttttttcc ttttatccaa agaacggggc      180

agttagtacg cttgccttcc tgtcgcccgg ttgggagcgg ggttggtgtg cggagtggtt      240

cgcctttttt tctttagaac ttgtgagcct tttttttttt tttttttttt tttctttttt      300

taggctcagt gctgtccggg ctggtttgcc cggtccctga ctaacggctt tctgcccctt      360

ctctcgccac ccctgcccaa ggtcgcccct ctgccttcgc ccctgtcccg ggagggtggg      420

aagctttgac cccgccctgc ccactcgcgt ctccgcagcc gtagccgcgc ctgtcccaat      480

atgaataggg tcaacgaccc acttattttt ataagagata ttaagcccgg actgaaaaac      540

ttaaatgtcg tctttattgt cctggagata ggacgcgtga ccaaaaccaa agacggccat      600

gaagtgagat cgtgcaaagt agcagataaa acgggcagca tcactatttc cgtgtgggat      660

gagatcggag gtcttataca gccaggggat attattcggt tgaccagagg gtatgcatcc      720

atgtggaaag gatgtctgac actttatact ggaaggggtg gtgaacttca aaaaattggg      780

gaattttgta tggtttattc agaagtgcca aatttcagtg aacccaaccc agattatcga      840

ggacagcaga acaaaggggc acagagtgaa cagaagaata attccatgaa tagtaatatg      900

ggtacaggta catttggacc agtgggaaat ggtgttcaca ctggccctga atcaagggaa      960

caccagtttt cacatgctgg cagaagcaat ggccggggac ttataaatcc acaactacaa     1020

ggaacagcta gtaatcaaac agtgatgacc acaataagta atggcaggga ccctcggaga     1080

gcctttaaaa gatgacctat gctaaatact catgtgtagt ttttatacta catgccctac     1140

ttgaacactt attgcacttt tatttattgt taactgtgaa aagtacgtcc tttattgggt     1200

ttccttttat attcttggtt tgttaagaag aatggtttgt ttttatagca aaactgttaa     1260

gctgctcgag tctcctgttg aagaatggga acactgaaaa gtaggggcat ttatttttag     1320

agtaaaaaga ttattggata gcctttaaaa aacctgcacc catttcatgg gtgagttact     1380

taagacatca gctttatagc ctctatgagt ctatcttctg tataagtttt gtaatattta     1440

acataaggct taatgggaga tgttcttttg tcttgtattc agatattgcc aactaaagca     1500

ataaccatca aaaaacacaa gaacttgtca atgctagcag taatttttga gtgtttgtgg     1560

ctctcggaat gattgacttc gttcagtgac tactattaag attttccaag gactgactca     1620

tcccaaattt ttgttgtatt accaaaaaaa cagattcctt atcagaattt ggaatagaat     1680

gtgatctcta ttgcaacaag taattttaaa agaaagctac atttatttta gagtagtgct     1740

cctaacatgt attatcaact ttgtggatta cattggagga aaatttaaaa ctggggcctt     1800

gaatatttat tttttgaaac taccatgtta aatactgaag tataatttgg gggagttata     1860

aagttatgat aaacattcat ctgattattt taaacaatag ttgtggtaga taaacatact     1920

ggaggtgagt caaattgaat tcatatagta acatgcagtc tgaagtccta gttacttaat     1980

aggtactcag cctggagtga aaatcctggg tactgacttt gagaggagtg agtgtgcatg     2040

ttgtcaaagt ttctgaacac agttcacata gccttattag caaaagtttt aagaaatggc     2100

tctatcaaag aagcaattgc agctttattc agaaatataa aagtggaatt tatgtacatg     2160

tcataagtgg tacccacttc ccctttttac tgtagggtgg ataactctta ggatttaact     2220

ctttgaatat tatctcttga ataaagcatg tgttaatgtt aacaaaccta cgtaattttt     2280

gccctttcaa tgacttacag tggagagcca gtacatctta actactgttg tagtgatggt     2340

atcaacctca tggttactta gctctgcatt tgttgctttg ttttttttcc acttcaaatc     2400

acaaaataag tagattttgt tttctgaaaa ctccatagca tttgaataca aaaagttgtg     2460

ccagattgtt tgccctaatt cactgtgttt aacaaatatt tcagtacaca ctatgtatta     2520

ggcactgtgt ggaaagtgtt aaggggtaga caaaataccg aataatctcc acaagtttat     2580

ttgtggtcta tagtactttt gtaactgggg ttacaaaaat tatagaaatt tttttccttt     2640

gttcatatgc atattcatga ttataatttg gctttgtttg tgattaatgt tttcttaaga     2700

ttttcacatt atagaatacc tcaaaagaag ttgtctaagg actgggatag agagtatgtt     2760

tcataaaatt gtagatgttt agaattttta aaaaccctac aaattagtat atgattgttt     2820

tatataagta agataggagc aacactttaa attatttgtg ggagaataca gcattaaagg     2880

tgattttaaa agaaaaaaat ttggaatttt agaaaattta aatgctgtca ggtatggaat     2940

gctgggcttc caatcctggc ctcattgtct cctcacctgt gatgttggat gagttattac     3000

acttgaaatg tctttaagcc ttaggttcca caagtatgaa aacaagtaag taacagtatc     3060

ctttctagac ttgtttaaga tttccatgta agtaattata atgacttctg acacataata     3120

atgtcgtctt ataccccaac agtaggaaaa aaatgcagaa ttcagtatga aagtattgtt     3180

accctttaac acagtggtcc ccaacctttt tggcaccaga gaccagtctc ctggaagaca     3240

gtttttccgt gggatcgggg gatggttttg ggatgaaact gttccacctc aggtcatcag     3300

tcattagtta gattctcata aggagcgtgc aacctcaatc ccttgcatac tcatttcaca     3360

atagggttca tgctcctatg agaatctaat gccaccactc atctgacagg aggtggagct     3420

caggcagtaa gtctccctcg cccgccactc acctgctggg cgttcctgtt cctagcaggc     3480

cagaattgat actgatctag gggttgggga cccctgctta acatgttgag attaaatgga     3540

gaaagactta agcttttact tttgtgattg acacttgctt caataatgta accttgttct     3600

gtgtttttat catttattaa caaatttctt ttttcttaag ggaagcctcc aaaatcaaag     3660

aaaagtgagt tacaatccat aatgaatatt tgccttacca gcctactgga acacattcat     3720

caagaactta agaggaagaa agttttctgc cttcctcctt cctagtgctc tcagctatca     3780

actttgaaat aagtttaaac aacacctact gaaaacaaaa accacttagt ataaaaatat     3840

cccccaccaa aaaaaaaaaa aaaaaa                                          3866


<210>  1090
<211>  204
<212>  PRT
<213>  Homo Sapiens

<400>  1090

Met Asn Arg Val Asn Asp Pro Leu Ile Phe Ile Arg Asp Ile Lys Pro 
1               5                   10                  15      


Gly Leu Lys Asn Leu Asn Val Val Phe Ile Val Leu Glu Ile Gly Arg 
            20                  25                  30          


Val Thr Lys Thr Lys Asp Gly His Glu Val Arg Ser Cys Lys Val Ala 
        35                  40                  45              


Asp Lys Thr Gly Ser Ile Thr Ile Ser Val Trp Asp Glu Ile Gly Gly 
    50                  55                  60                  


Leu Ile Gln Pro Gly Asp Ile Ile Arg Leu Thr Arg Gly Tyr Ala Ser 
65                  70                  75                  80  


Met Trp Lys Gly Cys Leu Thr Leu Tyr Thr Gly Arg Gly Gly Glu Leu 
                85                  90                  95      


Gln Lys Ile Gly Glu Phe Cys Met Val Tyr Ser Glu Val Pro Asn Phe 
            100                 105                 110         


Ser Glu Pro Asn Pro Asp Tyr Arg Gly Gln Gln Asn Lys Gly Ala Gln 
        115                 120                 125             


Ser Glu Gln Lys Asn Asn Ser Met Asn Ser Asn Met Gly Thr Gly Thr 
    130                 135                 140                 


Phe Gly Pro Val Gly Asn Gly Val His Thr Gly Pro Glu Ser Arg Glu 
145                 150                 155                 160 


His Gln Phe Ser His Ala Gly Arg Ser Asn Gly Arg Gly Leu Ile Asn 
                165                 170                 175     


Pro Gln Leu Gln Gly Thr Ala Ser Asn Gln Thr Val Met Thr Thr Ile 
            180                 185                 190         


Ser Asn Gly Arg Asp Pro Arg Arg Ala Phe Lys Arg 
        195                 200                 


<210>  1091
<211>  939
<212>  DNA
<213>  Homo Sapiens

<400>  1091
atgcccaatt caaccaccgt gatggaattt ctcctcatga ggttttctga tgtgtggaca       60

ctacagattt tacattctgc atccttcttt atgttgtatt tggtaactct aatgggaaac      120

atcctcattg tgaccgtcac cacctgtgac agcagccttc acatgcccat gtacttcttc      180

ctcaggaatc tgtctatctt ggatgcctgc tacatttctg ttacagtccc tacctcatgt      240

gtcaattccc tactggacag caccaccatt tctaaggcgg gatgtgtagc tcaggtcttc      300

ctcgtggttt tttttgtata tgtggagctt ctgtttctca ccattatggc tcatgaccgc      360

tatgtggctg tctgccagcc acttcactac cctgtgatcg tgaactctcg aatctgcatc      420

cagatgacac tggcctccct actcagtggt cttgtctatg caggcatgca cactggcagc      480

acattccagc tgcccttctg tcggtccaac gttattcatc aattcttctg tgacatcccc      540

tctctgctga agctctcttg ctctgacacc ttcagcaatg aggtcatgat tgttgtctct      600

gctctggggg taggtggcgg ctgtttcatc tttatcatca ggtcttacat tcacatcttt      660

tcgaccgtgc tcgggtttcc aagaggagca gacagaacaa aggccttttc cacctgcatc      720

cctcacatcc tggtggtgtc agtcttcctc agttcatgct cttctgtgta cctcaggcca      780

cctgcgatac ctgcagccac ccaggatctg atcctttctg gtttttattc cataatgcct      840

cccctcttta accctattat ttacagtctt agaaataagc aaataaaggt ggccatcaag      900

aaaatcatga agagaatttt ttattcagaa aatgtgtaa                             939


<210>  1092
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  1092

Met Pro Asn Ser Thr Thr Val Met Glu Phe Leu Leu Met Arg Phe Ser 
1               5                   10                  15      


Asp Val Trp Thr Leu Gln Ile Leu His Ser Ala Ser Phe Phe Met Leu 
            20                  25                  30          


Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr 
        35                  40                  45              


Cys Asp Ser Ser Leu His Met Pro Met Tyr Phe Phe Leu Arg Asn Leu 
    50                  55                  60                  


Ser Ile Leu Asp Ala Cys Tyr Ile Ser Val Thr Val Pro Thr Ser Cys 
65                  70                  75                  80  


Val Asn Ser Leu Leu Asp Ser Thr Thr Ile Ser Lys Ala Gly Cys Val 
                85                  90                  95      


Ala Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe 
            100                 105                 110         


Leu Thr Ile Met Ala His Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125             


His Tyr Pro Val Ile Val Asn Ser Arg Ile Cys Ile Gln Met Thr Leu 
    130                 135                 140                 


Ala Ser Leu Leu Ser Gly Leu Val Tyr Ala Gly Met His Thr Gly Ser 
145                 150                 155                 160 


Thr Phe Gln Leu Pro Phe Cys Arg Ser Asn Val Ile His Gln Phe Phe 
                165                 170                 175     


Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr Phe Ser 
            180                 185                 190         


Asn Glu Val Met Ile Val Val Ser Ala Leu Gly Val Gly Gly Gly Cys 
        195                 200                 205             


Phe Ile Phe Ile Ile Arg Ser Tyr Ile His Ile Phe Ser Thr Val Leu 
    210                 215                 220                 


Gly Phe Pro Arg Gly Ala Asp Arg Thr Lys Ala Phe Ser Thr Cys Ile 
225                 230                 235                 240 


Pro His Ile Leu Val Val Ser Val Phe Leu Ser Ser Cys Ser Ser Val 
                245                 250                 255     


Tyr Leu Arg Pro Pro Ala Ile Pro Ala Ala Thr Gln Asp Leu Ile Leu 
            260                 265                 270         


Ser Gly Phe Tyr Ser Ile Met Pro Pro Leu Phe Asn Pro Ile Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Lys Gln Ile Lys Val Ala Ile Lys Lys Ile Met Lys 
    290                 295                 300                 


Arg Ile Phe Tyr Ser Glu Asn Val 
305                 310         


<210>  1093
<211>  936
<212>  DNA
<213>  Homo Sapiens

<400>  1093
atgggcaagg aaaactgcac cactgtggct gagttcattc tccttggact atcagatgtc       60

cctgagttga gagtctgcct cttcctgctg ttccttctca tctatggagt cacgttgtta      120

gccaacctgg gcatgattgc actgattcag gtcagctctc ggctccacac ccccatgtac      180

tttttcctca gccacttgtc ctctgtagat ttctgctact cctcaataat tgtgccaaaa      240

atgttggcta atatctttaa caaggacaaa gccatctcct tcctagggtg catggtgcaa      300

ttctacttgt tttgcacttg tgtggtcact gaggtcttcc tgctggccgt gatggcctat      360

gaccgctttg tggccatctg taaccctttg ctatacacag tcaccatgtc ttggaaggtg      420

cgtgtggagc tggcttcttg ctgctacttc tgtgggacgg tgtgttctct gattcatttg      480

tgcttagctc ttaggatccc cttctataga tctaatgtga ttaaccactt tttctgtgat      540

ctacctcctg tcttaagtct tgcttgctct gatatcactg tgaatgagac actgctgttc      600

ctggtggcca ctttgaatga gagtgttacc atcatgatca tcctcacctc ctacctgcta      660

attctcacca ccatcctgaa gatgggctct gcagagggca ggcacaaagc cttctccacc      720

tgtgcttccc acctcacagc tatcactgtc ttccatggaa cagtcctttc catttattgc      780

aggcccagtt caggcaatag tggagatgct gacaaagtgg ccaccgtgtt ctacacagtc      840

gtgattccta tgctgaactc tgtgatctac agcctgagaa ataaagatgt gaaagaagct      900

ctcagaaaag tgatgggctc caaaattcac tcctag                                936


<210>  1094
<211>  311
<212>  PRT
<213>  Homo Sapiens

<400>  1094

Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Ile Ala Leu 
        35                  40                  45              


Ile Gln Val Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


His Leu Ser Ser Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly 
                85                  90                  95      


Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Leu Tyr Thr Val Thr Met Ser Trp Lys Val Arg Val Glu Leu 
    130                 135                 140                 


Ala Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Leu 
145                 150                 155                 160 


Cys Leu Ala Leu Arg Ile Pro Phe Tyr Arg Ser Asn Val Ile Asn His 
                165                 170                 175     


Phe Phe Cys Asp Leu Pro Pro Val Leu Ser Leu Ala Cys Ser Asp Ile 
            180                 185                 190         


Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser 
        195                 200                 205             


Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr 
    210                 215                 220                 


Ile Leu Lys Met Gly Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe His Gly Thr Val Leu 
                245                 250                 255     


Ser Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Ala Asp Lys 
            260                 265                 270         


Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Ser Val 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val 
    290                 295                 300                 


Met Gly Ser Lys Ile His Ser 
305                 310     


<210>  1095
<211>  4161
<212>  DNA
<213>  Homo Sapiens

<400>  1095
gcgcgcgggc ggcgtagccg gcctgtctgg gccgcctcgt ggggagggag ggggcgcccg       60

gccgcccggc ggcgaccccg gggcctggcc gccaccatgg gcttcgagct ggaccgcttc      120

gacggcgacg tggacccgga cctgaagtgc gcgctgtgcc acaaggtcct ggaggacccg      180

ctgaccacgc cgtgcggcca cgtcttctgc gccggctgcg tgctgccctg ggtggtgcag      240

gagggcagct gcccggcgcg ctgccgcggt cgcctgtcgg ccaaagagct caaccacgtc      300

ctgccgctca agcgccttat cctcaagctg gacatcaagt gcgcgtacgc gacgcgcggc      360

tgcggccggg tggtcaagct gcagcagctg ccggagcacc tcgagcgctg cgacttcgcg      420

cccgcgcgct gtcgccacgc gggttgcggc caggtgctgc tgcggcgcga cgtggaggcg      480

cacatgcgcg acgcgtgcga cgcgcggcca gtgggccgct gccaggaggg ctgcgggcta      540

cccttgacgc acggcgagca gcgcgcgggc ggccactgct gcgcgcgagc gctgcgggcg      600

cacaacggcg cgctccaggc ccgcctgggc gcgctgcaca aggcgctcaa gaaggaggcg      660

ctgcgcgctg ggaagcgcga gaagtcgctg gtggcccagc tggccgcggc gcagcttgag      720

ctgcagatga ccgcgctgcg ctaccagaag aaattcaccg aatacagcgc gcgcctcgac      780

tcgctcagcc gctgcgtggc cgcgccgccc ggcggcaagg gcgaagaaac caaaagtctg      840

actcttgtcc tgcatcggga ctccggctcc ctgggattca atattattgg tggccggccg      900

agtgtggata accacgatgg atcatccagt gaaggaatct ttgtatccaa gatagttgac      960

agtgggcctg cagccaagga aggaggcctg caaattcatg acaggattat tgaggtcaac     1020

ggcagagact tatccagagc aactcatgac caggctgtgg aagctttcaa gacagccaag     1080

gagcccatag tggtgcaggt gttgagaaga acaccaagga ccaaaatgtt cacgcctcca     1140

tcagagtctc agctggtgga cacgggaacc caaaccgaca tcacctttga acatatcatg     1200

gccctcacta agatgtcctc tcccagccca cccgtgctgg atccctatct cttgccagag     1260

gagcatccct cagcccatga atactacgat ccaaatgact acattggaga catccatcag     1320

gagatggaca gggaggagct ggagctggag gaagtggacc tctacagaat gaacagccag     1380

gacaagctgg gcctcactgt gtgctaccgg acggacgatg aagacgacat tgggatttat     1440

atcagtgaga ttgaccctaa cagcattgca gccaaggatg ggcgcatccg agaaggagac     1500

cgcattatcc agattaatgg gatagaggtg cagaaccgtg aagaggctgt ggctcttcta     1560

accagtgaag aaaataaaaa cttttcattg ctgattgcaa ggcctgaact ccagctggat     1620

gagggctgga tggatgatga caggaacgac tttctggatg acctgcacat ggacatgctg     1680

gaggagcagc accaccaggc catgcaattc acagctagcg tgctgcagca gaagaagcac     1740

gacgaagacg gtgggaccac agatacagcc accatcttgt ccaaccagca cgagaaggac     1800

agcggtgtgg ggcggaccga cgagagcacc cgtaatgacg agagctcgga gcaagagaac     1860

aatggcgacg acgccaccgc atcctccaac ccgctggcgg ggcagaggaa gctcacctgc     1920

agccaggaca ccttgggcag cggcgacctg cccttcagca acgagtcttt catttcggcc     1980

gactgcacgg acgccgacta cctggggatc ccggtggacg agtgcgagcg cttccgcgag     2040

ctcctggagc tcaagtgcca ggtgaagagc gccacccctt acggcctgta ctaccctagc     2100

ggccccctgg acgccggcaa gagtgaccct gagagcgtgg acaaggagct ggagctgctg     2160

aacgaagagc tgcgcagcat cgagctggag tgcctgagca tcgtgcgcgc ccacaagatg     2220

cagcagctca aggagcagta ccgcgagtcc tggatgctgc acaacagcgg cttccgcaac     2280

tacaacacca gcatcgacgt gcgcagacac gagctctcag atatcaccga gctcccggag     2340

aaatccgaca aggacagctc gagcgcctac aacacaggcg agagctgccg cagcaccccg     2400

ctcaccctgg agatctcccc cgacaactcc ttgaggagag cggcggaggg catcagctgc     2460

ccgagcagcg aaggggctgt ggggaccacg gaagcctacg ggccagcctc caagaatctg     2520

ctctccatca cggaagatcc cgaagtgggc acccctacct atagcccgtc cctgaaggag     2580

ctggacccca accagcccct ggaaagcaaa gagcggagag ccagcgacgg gagccggagc     2640

cccacgccca gccagaagct gggcagcgcc tacctgccct cctatcacca ctccccatac     2700

aagcacgcgc acatcccggc gcacgcccag cactaccaga gctacatgca gctgatccag     2760

cagaagtcgg ccgtggagta cgcgcaaagc cagatgagcc tggtgagcat gtgcaaggac     2820

ctgagctctc ccaccccgtc ggagccgcgc atggagtgga aggtgaagat ccgcagcgac     2880

gggacgcgct acatcaccaa gaggcccgtg cgggaccgcc tgctgcggga gcgcgccctg     2940

aagatccggg aagagcgcag cggcatgacc accgacgacg acgcggtgag cgagatgaag     3000

atggggcgct actggagcaa ggaggagagg aagcagcacc tggtgaaggc caaggagcag     3060

cggcggcggc gcgagttcat gatgcagagc aggttggatt gtctcaagga gcagcaagca     3120

gccgatgaca ggaaggagat gaacattctc gaactgagcc acaaaaagat gatgaagaag     3180

aggaataaga aaatcttcga taactggatg acgatccaag aactcttaac ccacggcaca     3240

aaatccccgg acggcactag agtatacaat tccttcctat cggtgactac tgtataattt     3300

tcacttctgc attatgtaca taaaggagac cactaccact ggggtagaaa ttcctgcctc     3360

gttcaatgcg gcaagttttt gtatataaga taagtacggt cttcatgttt atagtccaaa     3420

tttgcaaacc ctacaactct gggtgtcata ggtctatttt aagggaagag agagaaaaac     3480

acccttacta tcttggaagg caatattaac aaacagagct tttttcaaat agcaattgta     3540

cttttctacc tgtacccttt tacataaagt gtttaaattt cagaaagatc ttttattaag     3600

catactttca cagaataact tgtttaaact atattcatat aaaaaagtta aacacgcttt     3660

ttttcctgcc taaaacacaa atacaactgc cagtatgtat ttttaatgga accctatttt     3720

ataatggtac gttactgaat gtgtttcata tgcgtgaccg ttaagatatt atcatttagg     3780

tgaaggtttc aactcaaaac cacccaaccc ggtggttaac gatttaatac atataaccaa     3840

accggcagcg tttagagttg ggatatacat ttaaacattt tcctggttaa ggttcccaag     3900

agagtgtaaa ggttttagca gaaagcaaaa tatcttgcat ctttatggaa gtttaaagca     3960

tgtttgcaaa tattgcagcc cattgaaaga atttgcatgt acaggaaagt tgtggatgga     4020

gacggtttgt ggaattttaa gtgctcattg tagtaaactt ttgctttgta gatttgaagg     4080

tacagactta tacaggcaag ttcacaaaat catgattagt tacaaacagt aaaatgaagt     4140

taaaataaat tattattttc t                                               4161


<210>  1096
<211>  1066
<212>  PRT
<213>  Homo Sapiens

<400>  1096

Met Gly Phe Glu Leu Asp Arg Phe Asp Gly Asp Val Asp Pro Asp Leu 
1               5                   10                  15      


Lys Cys Ala Leu Cys His Lys Val Leu Glu Asp Pro Leu Thr Thr Pro 
            20                  25                  30          


Cys Gly His Val Phe Cys Ala Gly Cys Val Leu Pro Trp Val Val Gln 
        35                  40                  45              


Glu Gly Ser Cys Pro Ala Arg Cys Arg Gly Arg Leu Ser Ala Lys Glu 
    50                  55                  60                  


Leu Asn His Val Leu Pro Leu Lys Arg Leu Ile Leu Lys Leu Asp Ile 
65                  70                  75                  80  


Lys Cys Ala Tyr Ala Thr Arg Gly Cys Gly Arg Val Val Lys Leu Gln 
                85                  90                  95      


Gln Leu Pro Glu His Leu Glu Arg Cys Asp Phe Ala Pro Ala Arg Cys 
            100                 105                 110         


Arg His Ala Gly Cys Gly Gln Val Leu Leu Arg Arg Asp Val Glu Ala 
        115                 120                 125             


His Met Arg Asp Ala Cys Asp Ala Arg Pro Val Gly Arg Cys Gln Glu 
    130                 135                 140                 


Gly Cys Gly Leu Pro Leu Thr His Gly Glu Gln Arg Ala Gly Gly His 
145                 150                 155                 160 


Cys Cys Ala Arg Ala Leu Arg Ala His Asn Gly Ala Leu Gln Ala Arg 
                165                 170                 175     


Leu Gly Ala Leu His Lys Ala Leu Lys Lys Glu Ala Leu Arg Ala Gly 
            180                 185                 190         


Lys Arg Glu Lys Ser Leu Val Ala Gln Leu Ala Ala Ala Gln Leu Glu 
        195                 200                 205             


Leu Gln Met Thr Ala Leu Arg Tyr Gln Lys Lys Phe Thr Glu Tyr Ser 
    210                 215                 220                 


Ala Arg Leu Asp Ser Leu Ser Arg Cys Val Ala Ala Pro Pro Gly Gly 
225                 230                 235                 240 


Lys Gly Glu Glu Thr Lys Ser Leu Thr Leu Val Leu His Arg Asp Ser 
                245                 250                 255     


Gly Ser Leu Gly Phe Asn Ile Ile Gly Gly Arg Pro Ser Val Asp Asn 
            260                 265                 270         


His Asp Gly Ser Ser Ser Glu Gly Ile Phe Val Ser Lys Ile Val Asp 
        275                 280                 285             


Ser Gly Pro Ala Ala Lys Glu Gly Gly Leu Gln Ile His Asp Arg Ile 
    290                 295                 300                 


Ile Glu Val Asn Gly Arg Asp Leu Ser Arg Ala Thr His Asp Gln Ala 
305                 310                 315                 320 


Val Glu Ala Phe Lys Thr Ala Lys Glu Pro Ile Val Val Gln Val Leu 
                325                 330                 335     


Arg Arg Thr Pro Arg Thr Lys Met Phe Thr Pro Pro Ser Glu Ser Gln 
            340                 345                 350         


Leu Val Asp Thr Gly Thr Gln Thr Asp Ile Thr Phe Glu His Ile Met 
        355                 360                 365             


Ala Leu Thr Lys Met Ser Ser Pro Ser Pro Pro Val Leu Asp Pro Tyr 
    370                 375                 380                 


Leu Leu Pro Glu Glu His Pro Ser Ala His Glu Tyr Tyr Asp Pro Asn 
385                 390                 395                 400 


Asp Tyr Ile Gly Asp Ile His Gln Glu Met Asp Arg Glu Glu Leu Glu 
                405                 410                 415     


Leu Glu Glu Val Asp Leu Tyr Arg Met Asn Ser Gln Asp Lys Leu Gly 
            420                 425                 430         


Leu Thr Val Cys Tyr Arg Thr Asp Asp Glu Asp Asp Ile Gly Ile Tyr 
        435                 440                 445             


Ile Ser Glu Ile Asp Pro Asn Ser Ile Ala Ala Lys Asp Gly Arg Ile 
    450                 455                 460                 


Arg Glu Gly Asp Arg Ile Ile Gln Ile Asn Gly Ile Glu Val Gln Asn 
465                 470                 475                 480 


Arg Glu Glu Ala Val Ala Leu Leu Thr Ser Glu Glu Asn Lys Asn Phe 
                485                 490                 495     


Ser Leu Leu Ile Ala Arg Pro Glu Leu Gln Leu Asp Glu Gly Trp Met 
            500                 505                 510         


Asp Asp Asp Arg Asn Asp Phe Leu Asp Asp Leu His Met Asp Met Leu 
        515                 520                 525             


Glu Glu Gln His His Gln Ala Met Gln Phe Thr Ala Ser Val Leu Gln 
    530                 535                 540                 


Gln Lys Lys His Asp Glu Asp Gly Gly Thr Thr Asp Thr Ala Thr Ile 
545                 550                 555                 560 


Leu Ser Asn Gln His Glu Lys Asp Ser Gly Val Gly Arg Thr Asp Glu 
                565                 570                 575     


Ser Thr Arg Asn Asp Glu Ser Ser Glu Gln Glu Asn Asn Gly Asp Asp 
            580                 585                 590         


Ala Thr Ala Ser Ser Asn Pro Leu Ala Gly Gln Arg Lys Leu Thr Cys 
        595                 600                 605             


Ser Gln Asp Thr Leu Gly Ser Gly Asp Leu Pro Phe Ser Asn Glu Ser 
    610                 615                 620                 


Phe Ile Ser Ala Asp Cys Thr Asp Ala Asp Tyr Leu Gly Ile Pro Val 
625                 630                 635                 640 


Asp Glu Cys Glu Arg Phe Arg Glu Leu Leu Glu Leu Lys Cys Gln Val 
                645                 650                 655     


Lys Ser Ala Thr Pro Tyr Gly Leu Tyr Tyr Pro Ser Gly Pro Leu Asp 
            660                 665                 670         


Ala Gly Lys Ser Asp Pro Glu Ser Val Asp Lys Glu Leu Glu Leu Leu 
        675                 680                 685             


Asn Glu Glu Leu Arg Ser Ile Glu Leu Glu Cys Leu Ser Ile Val Arg 
    690                 695                 700                 


Ala His Lys Met Gln Gln Leu Lys Glu Gln Tyr Arg Glu Ser Trp Met 
705                 710                 715                 720 


Leu His Asn Ser Gly Phe Arg Asn Tyr Asn Thr Ser Ile Asp Val Arg 
                725                 730                 735     


Arg His Glu Leu Ser Asp Ile Thr Glu Leu Pro Glu Lys Ser Asp Lys 
            740                 745                 750         


Asp Ser Ser Ser Ala Tyr Asn Thr Gly Glu Ser Cys Arg Ser Thr Pro 
        755                 760                 765             


Leu Thr Leu Glu Ile Ser Pro Asp Asn Ser Leu Arg Arg Ala Ala Glu 
    770                 775                 780                 


Gly Ile Ser Cys Pro Ser Ser Glu Gly Ala Val Gly Thr Thr Glu Ala 
785                 790                 795                 800 


Tyr Gly Pro Ala Ser Lys Asn Leu Leu Ser Ile Thr Glu Asp Pro Glu 
                805                 810                 815     


Val Gly Thr Pro Thr Tyr Ser Pro Ser Leu Lys Glu Leu Asp Pro Asn 
            820                 825                 830         


Gln Pro Leu Glu Ser Lys Glu Arg Arg Ala Ser Asp Gly Ser Arg Ser 
        835                 840                 845             


Pro Thr Pro Ser Gln Lys Leu Gly Ser Ala Tyr Leu Pro Ser Tyr His 
    850                 855                 860                 


His Ser Pro Tyr Lys His Ala His Ile Pro Ala His Ala Gln His Tyr 
865                 870                 875                 880 


Gln Ser Tyr Met Gln Leu Ile Gln Gln Lys Ser Ala Val Glu Tyr Ala 
                885                 890                 895     


Gln Ser Gln Met Ser Leu Val Ser Met Cys Lys Asp Leu Ser Ser Pro 
            900                 905                 910         


Thr Pro Ser Glu Pro Arg Met Glu Trp Lys Val Lys Ile Arg Ser Asp 
        915                 920                 925             


Gly Thr Arg Tyr Ile Thr Lys Arg Pro Val Arg Asp Arg Leu Leu Arg 
    930                 935                 940                 


Glu Arg Ala Leu Lys Ile Arg Glu Glu Arg Ser Gly Met Thr Thr Asp 
945                 950                 955                 960 


Asp Asp Ala Val Ser Glu Met Lys Met Gly Arg Tyr Trp Ser Lys Glu 
                965                 970                 975     


Glu Arg Lys Gln His Leu Val Lys Ala Lys Glu Gln Arg Arg Arg Arg 
            980                 985                 990         


Glu Phe Met Met Gln Ser Arg Leu  Asp Cys Leu Lys Glu  Gln Gln Ala 
        995                 1000                 1005             


Ala Asp  Asp Arg Lys Glu Met  Asn Ile Leu Glu Leu  Ser His Lys 
    1010                 1015                 1020             


Lys Met  Met Lys Lys Arg Asn  Lys Lys Ile Phe Asp  Asn Trp Met 
    1025                 1030                 1035             


Thr Ile  Gln Glu Leu Leu Thr  His Gly Thr Lys Ser  Pro Asp Gly 
    1040                 1045                 1050             


Thr Arg  Val Tyr Asn Ser Phe  Leu Ser Val Thr Thr  Val 
    1055                 1060                 1065     


<210>  1097
<211>  6271
<212>  DNA
<213>  Homo Sapiens

<400>  1097
agctccccgc ctgctcccgg aggccgcagc ctccagctcc gctcgcgctc tcgccgctcc       60

tgccggctcg cccggccccg cgctccgccg tctcctcgcc gcccgcccct ccgccagccc      120

cggggaccgc gcggccgcag cctgagccag ggccccctcc ctcgtcagga ccggggcagc      180

aagcaggccg ggggcaggtc cgggcaccca ccatgcgagg cgagctctgg ctcctggtgc      240

tggtgctcag ggaggctgcc cgggcgctga gcccccagcc cggagcaggt cacgatgagg      300

gcccaggctc tggatgggct gccaaaggga ccgtgcgggg ctggaaccgg agagcccgag      360

agagccctgg gcatgtgtca gagccggaca ggacccagct gagccaggac ctgggtgggg      420

gcaccctggc catggacacg ctgccagata acaggaccag ggtggtggag gacaaccaca      480

gctattatgt gtcccgtctc tatggcccca gcgagcccca cagccgggaa ctgtgggtag      540

atgtggccga ggccaaccgg agccaagtga agatccacac aatactctcc aacacccacc      600

ggcaggcttc gagagtggtc ttgtcctttg atttcccttt ctacgggcat cctctgcggc      660

agatcaccat agcaactgga ggcttcatct tcatggggga cgtgatccat cggatgctca      720

cagctactca gtatgtggcg cccctgatgg ccaacttcaa ccctggctac tccgacaact      780

ccacagttgt ttactttgac aatgggacag tctttgtggt tcagtgggac cacgtttatc      840

tccaaggctg ggaagacaag ggcagtttca ccttccaggc agctctgcac catgacggcc      900

gcattgtctt tgcctataaa gagatcccta tgtctgtccc ggaaatcagc tcctcccagc      960

atcctgtcaa aaccggccta tcggatgcct tcatgattct caatccatcc ccggatgtgc     1020

cagaatctcg gcgaaggagc atctttgaat atcaccgcat agagctggac cccagcaagg     1080

tcaccagcat gtcggccgtg gagttcaccc cattgccgac ctgcctgcag cataggagct     1140

gtgacgcctg catgtcctca gacctgacct tcaactgcag ctggtgccat gtcctccaga     1200

gatgctccag tggctttgac cgctatcgcc aggagtggat ggactatggc tgtgcacagg     1260

aggcagaggg caggatgtgc gaggacttcc aggatgagga ccacgactca gcctcccctg     1320

acacttcctt cagcccctat gatggagacc tcaccactac ctcctcctcc ctcttcatcg     1380

acagcctcac cacagaagat gacaccaagt tgaatcccta tgcaggagga gacggccttc     1440

agaacaacct gtcccccaag acaaagggca ctcctgtgca cctgggcacc atcgtgggca     1500

tcgtgctggc agtcctcctc gtggcggcca tcatcctggc tggaatttac atcaatggcc     1560

accccacatc caatgctgcg ctcttcttca tcgagcgtag acctcaccac tggccagcca     1620

tgaagtttcg cagccaccct gaccattcca cctatgcgga ggtggagccc tcgggccatg     1680

agaaggaggg cttcatggag gctgagcagt gctgagaaca ccaagtctcc cctttgaaga     1740

ctttgaggcc acagaaaaga cagttaaagc aaagaagaga agtgactttt cctggcctct     1800

cccagcatgc cctgggctga gatgagatgg tggtttatgg ctccagagct gctgctcgct     1860

tcgtcagcac accccgaata ttgaagaggg ggccaaaaaa caaccacatg gattttttat     1920

aggaacaaca acctaatctc atcctgtttt gatgcaaggg ttctcttctg tgtcttgtaa     1980

ccatgaaaca gcagaagaac taacataact aactccattt ttgtttaagg ggcctttacc     2040

tattcctgca cctaggctag gataacttta gagcactgac ataaaacgca aaaacaggaa     2100

tcatgccgtt tgcaaaacta actctgggat taaaggggaa gcatgtaaac agctaactgt     2160

ttttgttaaa gatttatagg aatgaggagg tttggctatt gtcacatgac agactgttag     2220

ccaaggacaa agaagttctg caaacctccc ctggaccctt gctggtgtcc agatgtctgc     2280

ggttgtcagc cccttccttt cccccgacct aaacataaaa gacaaggcaa agcccgcata     2340

attttaagac ggttctttag gacattagtc caccatcttc ttggtttgct ggctctccga     2400

aataaagtcc ctttccttgc tccaactcct tgtctctcaa cgtattggct atgacgcagc     2460

aagcagaatg aatttggact cagttacagg ctgtcaatgg tctgctctgt agcagtctca     2520

gagcctcccc gacccactac ctggagatag ccagatagcc agatgccctg ctcctggcca     2580

cctttaaagc ccctgcatat gacacaggtt aactaaagtc aagattgggg ctgctgcatt     2640

ccaggttccc tagactcaca agctggtcct tggccaggtg cagtggctca cgcctgtaat     2700

cccagcactt tgggaggctg aggcaggcgg atcacctgaa gtcagaagtt tgagaccagc     2760

ctggccaaca taattaaaat gtctctacta aaaatacaaa aaattagctg ggtgtggtga     2820

cgcttgcctg tatcccagct actcaggaag ctgagacacg agaatcactt gaacctggga     2880

ggcagaggtt gcagtgagct cagatagtgc cactgcactc cagcctgggt gacagagcga     2940

gactccgtct caaaaaaaaa aaaagaaagc agatcctcat ggctatagag ttggcatttt     3000

agccccagct tctgtagctc tgaaagccta aagaaggtat tctctccatc tgttaaacac     3060

agtatagtgg ctctcagccc ttggggcatg ttatcatggg agggaagtca aataagagga     3120

gagaaaagaa ctcaaggggg aaactgcatt tttaggcttt gctctcttac cttgcccttt     3180

ctactcagaa ccaataactt ctgcatcaaa acatgttaca gcctgcatca agggctttac     3240

cccaacctgc agcccagcct tccctgggtg agcttgctat gcgcagccac atttaccatg     3300

tggggctccc tattctgatg gcctgttcgg tgccgggttt actcactgcc ctgttctgat     3360

gtcagtgcct gtacatacct ccaaaggcag gacttgcctg ataaatattt ttcctcctct     3420

gaactggatt ttataggcat taaagacaag tcgggtggct agagggctcc ttgagacata     3480

cctagcaggg aactgcaggt ggattctgtt gagaggcaaa gcacctgagt ggttgggaca     3540

caggcagctg gcatgggagg gacttttttt gagacagggt ctcactgtgt cgcccagggc     3600

aaggatgccc aaagacacca ggttggagag gcacctgcca actacttgct ttccctggag     3660

cctgcatgtg cctgtggggt ggggaggcgt aggggtctac ggctgcctga gatgggtgtg     3720

cacagtgtgt gaagtaccta cctccttgcc ttgctggact gtcagccagt cgcagggccg     3780

gccacaagac ccatgtctcc atctggtcat actccatagc taccaagtta acctgctcta     3840

aactttggag aactggatct gtccaataaa cgcttatttg gccaagcctg atggctcgtg     3900

cctgtactcc cagcactttg ggaggctgag gtgggagggt tgcttgagcc caggggtttg     3960

agaccagctt gggcaacaac aacaaaaatg ccaggtgtgg tggggtgcac ctgtagtccc     4020

agctactagg gaggctgagc caggaggatc acttgagccc gggaggttga ggctgcagtg     4080

gggggtcata atcatgccac tgtactccag cctgggtgac agagtgagac cctgtctccg     4140

aaaaaaaaaa aaaaaaaaag aacggaaaaa gaaatgctta cattgtcagg gatcctgtag     4200

acaatcatta actctatgag atgcttggtt ctattttttt gggagacttt gtccaagtgt     4260

tttggcttaa gaaatccata ggcctctctt ggtgacacat ctctagtact ttttgtcata     4320

aacaaacagg ccatctgccg ccaaatacat ccactcccca tgccactgac atcctatggg     4380

tcagccaggc ttgctttgac tgaggccgag gcatctggaa ctttctctgc ctgcaggggc     4440

tagcagcaga ggcttcaccg catcaccacc ccttcctcca ctcctgacat tctttccctt     4500

cagggatcca aaatggttgg ccgagctccc agtgggaaaa cgtgtgctag agttggggag     4560

tgagatgagt ggtgctgtcc atggaatcag gccacagcag gaactgcccc actggccatt     4620

tgagacacac acaggtggta aatgctctgc tggtgggctg tgcttccctc attcagagag     4680

ctctgttaca gcccactgtg tcctttagaa gcttgaaagg aacccaactc tttgctgcac     4740

tgtccttttt cttcctcaaa ttcagaccct ccttccaccg gcacccccct actccaccct     4800

cagctcttcc ttgcctggtt tatcaagcag agctgaggcc ccacgtttcc aactctgatt     4860

gtcacttgca tcttcacaaa ggataaacca cggagcaact ggaaaaccat cagccaagcg     4920

ttcggatgag tctggttatt ggtccacccc cgaccagatt cccttacact taactcactt     4980

ctttctttgg caatgaccct catgacatgt ataaatgggt atgactaaga agaggctgtg     5040

atctaacatt tatttgctgc cattttttac tctggggaga agcagcccca actcatcact     5100

gggaaagaac tccccctgca aaccagctaa atttgataat ttaaaccccc tgcccctaaa     5160

acttctcaca gagctgggga gttggtggca actttccaag tcaaggtctt gcttagaaag     5220

tccttcacta catggccagg tgcagtggct cacgcctgta gtcccaggta cttgggagcc     5280

tgaggcagga ggattgcttg agctcaggag ttcaaggctg cagagagcta tgatcatccc     5340

actgcatttg tttaaaaata aatttttaaa atttgtgtgt tttatcaggg gtctcctgta     5400

cagtgtatct gtgtatgttt gtgtgtgtgt ttgtatacag ccttgtttaa tgttttgagc     5460

aataagatat gcacacacag gtattttgtt gctaaagaga ttggacaagg ttgtagctgt     5520

gctcaggctt cagcttggtt tgttaaattg agagataaac aatgacaaga gctgccagcc     5580

aaccacacta ttcaaaaagc aaagtgttca ccactaaagc taaccattca tctggttgca     5640

ggcaaggcta aggctctctc tcctctagtt cctggaacag actcacagat tggcatgaag     5700

cactgatcag gggctgcact cagactccct ggccaagcaa acctacacca gaagagtcag     5760

tgtcacagat atgatgcggc caatctctgt ctccaaaaac ctacctgaac ttaatggtag     5820

aattcaaaga tctggggact gagggcaccc agccttctaa aacacaatgt attcatgtgt     5880

ttagtgtaaa ctctctgcat ggattctcag tgttaataat aaaaggaagc attcttttac     5940

aactcctgct gtgtgcaaaa gaaagtgcaa aggatttgga gtggcattcc gaagatcacc     6000

acacatacct tggttctgat ggctgctgaa ctccgacttc ttcgctgaga catgactgtg     6060

ggaacagcct ccagctatct gctcatcaga ggtgctttcc tcaacctcct gcaccacctc     6120

caagagaaac agcctaaaaa gaaaccccag ctgtttactt atattggtct gtaaatccct     6180

ggaagtaaac cccatgcatt tttatctact gtctgaggac atacaataaa tctgagaaag     6240

tctatgctgt caaaaaaaaa aaaaaaaaaa a                                    6271


<210>  1098
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  1098

Met Arg Gly Glu Leu Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala 
1               5                   10                  15      


Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly 
            20                  25                  30          


Ser Gly Trp Ala Ala Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala 
        35                  40                  45              


Arg Glu Ser Pro Gly His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser 
    50                  55                  60                  


Gln Asp Leu Gly Gly Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn 
65                  70                  75                  80  


Arg Thr Arg Val Val Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu 
                85                  90                  95      


Tyr Gly Pro Ser Glu Pro His Ser Arg Glu Leu Trp Val Asp Val Ala 
            100                 105                 110         


Glu Ala Asn Arg Ser Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr 
        115                 120                 125             


His Arg Gln Ala Ser Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr 
    130                 135                 140                 


Gly His Pro Leu Arg Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe 
145                 150                 155                 160 


Met Gly Asp Val Ile His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala 
                165                 170                 175     


Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val 
            180                 185                 190         


Val Tyr Phe Asp Asn Gly Thr Val Phe Val Val Gln Trp Asp His Val 
        195                 200                 205             


Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala 
    210                 215                 220                 


Leu His His Asp Gly Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met 
225                 230                 235                 240 


Ser Val Pro Glu Ile Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu 
                245                 250                 255     


Ser Asp Ala Phe Met Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser 
            260                 265                 270         


Arg Arg Arg Ser Ile Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser 
        275                 280                 285             


Lys Val Thr Ser Met Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys 
    290                 295                 300                 


Leu Gln His Arg Ser Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe 
305                 310                 315                 320 


Asn Cys Ser Trp Cys His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp 
                325                 330                 335     


Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu 
            340                 345                 350         


Gly Arg Met Cys Glu Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser 
        355                 360                 365             


Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser 
    370                 375                 380                 


Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr Glu Asp Asp Thr Lys Leu 
385                 390                 395                 400 


Asn Pro Tyr Ala Gly Gly Asp Gly Leu Gln Asn Asn Leu Ser Pro Lys 
                405                 410                 415     


Thr Lys Gly Thr Pro Val His Leu Gly Thr Ile Val Gly Ile Val Leu 
            420                 425                 430         


Ala Val Leu Leu Val Ala Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn 
        435                 440                 445             


Gly His Pro Thr Ser Asn Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro 
    450                 455                 460                 


His His Trp Pro Ala Met Lys Phe Arg Ser His Pro Asp His Ser Thr 
465                 470                 475                 480 


Tyr Ala Glu Val Glu Pro Ser Gly His Glu Lys Glu Gly Phe Met Glu 
                485                 490                 495     


Ala Glu Gln Cys 
            500 


<210>  1099
<211>  7853
<212>  DNA
<213>  Homo Sapiens

<400>  1099
gagtatcacc tgatgggtgc ctgactttcc tggtggggtg cagggccctc tcctgccctc       60

tttgtgtctg actagctacc cactgtaaca aaatgttcac accaagtggg ataaagatta      120

taaagaattt cacgtcaatt cagttcagct gttgctacaa aattagctat gccgagcttt      180

ggacctttga agcttttttc cccccccaac tttatttaga agaacaaatc taggtcccag      240

tgccccccat gtcctcccca aacccccacc ataatttaag taatttagag ttgaagggag      300

gagaaagaaa ggggagggat gaggaagaag agcccactgc agccctggcg atgggattct      360

cggccacccc agggcccccg gggaccagag gttcggtgga ggaggctgca gctcctgggc      420

ccaccatgcc ccccagatct ccacacatgg ttctccaaga gcaggtagcc tgacccctgg      480

ttaagtgcag actccaggtg gctcagccgg cacctgatgg tcagcagcac acatcagaca      540

cgcagctcaa ccgtccagtt cctccggatc ttactgctgg cacccatatt gaggtggaag      600

gaagcctttg ggtggagcga tgtggaagtc cttcctcatc aggagtttca catggtacag      660

gccccagggt cctcaaaggt gacctgcagg tctgcgagca cctccttgtt gggaaagatc      720

tttaagtcat ccagcaggtt ttgcagtcaa tgtcgttacc tccttgtgca ccaggccatc      780

atggggagag caggttcttc acattcaagt ccatgactgt ggctggacaa gggtgagtct      840

ctgccaccca cccccgtccc cgcatccctg ccctccctcc tctaaaccac acaccccaga      900

aacaggttct gggatttggg aatccctcta aggaatcatg gacacatagg ttgtattgaa      960

tcatccttct gcttgtgtca atcctctcca ggtaaatcaa tcctggatca ggcagcaggt     1020

gcaggctgtg gaaggcttct cactctggaa tgctcacagc tgggccagag gaggaagccc     1080

cactctctgg gcatttccag gacgtaggac agagaattag aggtgctgag ctccctggct     1140

ggctgcctca cagagctgtg tgcccctagg gaaagtgttg cacccacctc cctggtctac     1200

taactgtgga ggcagagaag gaaacccctg atgctcccag tggttctgtg cagctgaagg     1260

ccgctgtgag gctatgggga cttccagacc agggcagagc ccccacattc tctgcactct     1320

tgggcaggga ttttaaccac cagcccctgc ttcctcccct gtcactgtct gggaatgtgg     1380

gttctggagt cctactgcct gggtcagagt ccaccccacc aggcagctct gcttggactt     1440

agttatctaa gcctcggttt ctttacctgg ataatgagcg tgataataat gacacccacc     1500

tcttaaagtg agagacttga caaagctagc gtgggtccag ctcagtgcct gggcgtacag     1560

aaggcacaca acacaagaga aggctctgag tcctactgtg gagattaggc ctgtggcagt     1620

gtcctgtggt tgccgaaaga aattaccaca accttggtgg cttaaaatga cagaaattgg     1680

tactctcaca gttctggagg ctagaagtct gaaatcaagg aatcagccag gttggctcct     1740

tctgcaggct ctgaggcaga atctatccca gcctctcttt ggctcctgtt ggatcctggt     1800

ggtccttggg tcctcagctt tgagatgcat cactccagtc tctacctctg tctttgcaag     1860

gccttcttct tatgtctttg tgtatcattt ctctctctcc tttcttttat taggatacca     1920

gtcattggat ttagggtgga ccctaaatcc agaatgatct catctcaaga cctttagctt     1980

aattcaatat gcaaagacct tatttccaca tcaggtcata gtcacaggta caaggggtta     2040

ggacttgaac atatcttttt ggggggcacc attcagcccc actacagcac tagggttggg     2100

gcacaaagct cctagggttg gaagagtggc acagcagcca cccacatgtg atggcaaatt     2160

gttcttagac ccctagaggg gtcgctgatg gggtcactcg gtacggcggt cacatagtta     2220

aaggctagag gttttttaat ggggcagacc tagtggcaag ccctaaggca gcgagcaagt     2280

ttattttacc aaagtaaaac tccatttcct catctctaaa atgaacatga gacgccccac     2340

ttcaggaatt ctcttgaaga ctaaagacaa caggtttaca gtgtctagtc cataataata     2400

aaaatgaaac aaaacaacaa caacaaaaat aagtctaatc cataaaactc tcagtcagtg     2460

aaatgccctc ccctgccccc actttcggtc ctctctgaaa tcaggaacct gatcgggccc     2520

tcccattgtt agaacacttc agtgccagtc acggcaggag gctggttatc tgaagggcct     2580

tccccagtgc caatcggttg gcaaggtcca gatctgcatt gcagataagc gcttgattac     2640

tggggacaga ttctatggaa ctgctccctt catgagaaac accattaaca acccaaactc     2700

acaagcccca acctttctga cacccagaga gaacagccag gctttgctct tcaagccaaa     2760

acctggtatc tgatgcaaaa cgagtctggg atgggtttca aagcaggagt ctagattccc     2820

ccaaagccct gtgaggggcc acagacacag ctcacacaat gaagcttggg ccattcagac     2880

ctgggaaagg tcaaggccag gcaggttctc atgtccttct gcaattagaa acctgcaccc     2940

cagcaaagcc ccctggtctg gtttgggtgt gtcccccagt gttcatgtgt tggaaactta     3000

attcccaatg catcagtgtt aagaggtggg accttcaaca ggtgctcagg tcatgaggga     3060

tgagtagatc aatgtggtta tcaaggagtg ggtttgtcat catgagtgag ctgttataaa     3120

ggtgagtttg ggtctctctt gctctctctc accctttctt tgcccttcct caatgggatg     3180

atgtagcaag aaggccccca ctagatgtgg gtcccccaac tttggacttc ccagcctcca     3240

gaactgtaag aatacatttc ttttctttat aaattactca gtctgtggca ttttgttaca     3300

gcagcacaaa acagactaag acatccccat cccagggttg gttggaaagc cccagccctg     3360

tcccaccagg tcacagttct ctttggtcac taagaatgct cctgatgcct gctttgtttc     3420

ctgggacacg gggagacttt cttttcctgg tccattctta caacacaggg cagggtttct     3480

atttttgttg tagaatagcc tgtgcacagg gcacagcatt ttaattcctc agctaataat     3540

ttgattcctc accaataata ctgccaagca gtaagtttct tttttaatgt tgtcatttgc     3600

tggttttttg tcatgagacc tcaaggaaca cagagggaca ctctttttag ccatctgagg     3660

gctggatgaa tggctttagc tgccagcgcc tgcccagctt tgtttccact ctgcccctgg     3720

aagggaatcg cccagcaggc ttcatctctg cctctgaccc tcccactctt gttctggagc     3780

ctgctctttt tgggatcctc ccgaaaccac aggatttttc caacgcaaag ggaacctcca     3840

cctgggaagc accagaagcc ctttcccttc acccatcctc ctggctcctc cttcttccag     3900

ttcctgaatc caactcttca tgaagccagg aaggtcgctg cccacctttc ctgtccttcc     3960

ccttggcctg ccccaagtgg gtggagtggt gagataataa ctgcagcagc ccagcttcca     4020

ggcatggctt tttaatgttt ccgaggcact gagcaaagtg ccctcaatgc attatcccag     4080

tcaacactta gcccatttta cagaagagga aaatgcagcc cagagaggtc atagatgggt     4140

tccctgggct ccaaggcatt gaaactccag cggggtcgat gaaagggcag ggggcactgg     4200

agattggtgc tttgcttttt agactttgat gagggttcaa caggaaatgg aaaagagtgg     4260

ggcagaaaag catgaccctg caggggcttc acactgctat ggcggtgggg cctcagttac     4320

ctatctgtcc ggacttctgg gaaaacacct acacgggcat gggcaggggg ttcgagagtt     4380

gtctgaggca ctccaaggct ggaggccctc attggtgcac aggaatcagg tcagggcatg     4440

gcgaaacata tggcaccgac actgttcacc agacacacat tctcctcttc caggttgacc     4500

aaattttccc tgcttgcagc aacaaggagc tataacaaga aagaaacacc cagaccctag     4560

agccaaccca tcaactatac tgtgtgagcc taaatccacc cctctcccgc cccgccagag     4620

tagatgacaa acccccatac tcctatccct ctggtgtccc tgtactgccc ccgatggcca     4680

gctgcttctc ctgactgaag atgcttatct ttttagtggt ttggtaggac tggggcttct     4740

ggccatccat tattctgcag aattactaaa tccattttct aattcccaga gagcttggca     4800

atgatatctt attgatttga ttatttccct ccctgctgct gactccctct ttttacaact     4860

tatttttttt taagatgggg tggggggggt ctcactttgt cgcccaggct ggagggcagt     4920

ggtgcgatca tggctcactg cagcctcgac ctcctgggct caggtgatct tcctacctca     4980

tcctctagag tagctggaac tacaggcact agccaccaca cctggctatt tctttatttt     5040

ttgtagagac aagatctcac tatgttgccc aggctggtct ccaactcctg agctcaagca     5100

atcctcctgc ctcagccttc taaaatgctg ggattacaga catgagccat catgctgggg     5160

ctggctccct ctttatctgt gagaacagaa agcgtacgga tggattggtg gttggtgcca     5220

cccaaacccc tgatctctcc accagctcca ccttctcagt tttcttcagt gcaggattcc     5280

tggggtggaa accagccagc gtgtctggat gggcctgcac gccccctcca agtccattca     5340

ttgaactaac ttctggtctg ggctggtcag tgcgattctg agagtcctgc tctcaaagac     5400

acagaagaag gagcagagcc agtcctcacc cttttcccag ggaattttgg ggcaacttaa     5460

tggcagtgga tatttttagg gagggaatgt caataaatat tagtaattat gattgatatt     5520

aattaggatt gagttgtggg actatcaaaa tgacttggtg gtgatttccc tcgtggcaat     5580

agaaatgcct ttagtggaag tgcatttctc ttccactctg gaaacctcag agtcaaaatc     5640

ccagcaaggg aaaggaattt cacagtggca tgcctgggca aactgatggg cgaaaatacc     5700

atcagcgcca tgtgcttaga atgaaagccc tcacccacag tcgtctgggg gttaggatcc     5760

agccctggct taacaatgtg taacttctcg gtgattgtgg aactcggaga aattacaccc     5820

gtcatttgat atcaattact attccagcct tctcagttga actaaactcc tcagaacaga     5880

agatctccag gtctgtggta gtttctgcta ctttaggcta cttttttggg tggggcaggg     5940

gggcaagatg aggacattca cagcagccac tgttcttctt tgttccagtg atagcgacac     6000

tgcagccatc tccagggaac cagtggcctg tttgctgtgt gtgcttccac actggcctcc     6060

cacgtgccag ctggtgttac ctgcgtcgct cactcctgct gctggagtgg ctgcgtcagc     6120

agggggagct gagagcagta agtggctgga acagcccagg gaaggaggag atccctggga     6180

agcaagatcg gagttcacgt ggaggacgct ggaaccacag aagcatgtgt gtttgtggca     6240

acctcacggc tccactgctg gagttaatga tccatgagca aaacactgag cccatccaca     6300

ctggccgctg gcggatggac accgccatgc tagatctgtg cggtcgcccg gggagcaccg     6360

ggccattcct aacaagcgtg cagtcgagat gcagacagga aggccaaggg agggagaagg     6420

gggcttcagc acacggcagc gcgtggcccc tgggcccgac cccttctccg gcagcgcagc     6480

agtcctccac cttgtcttgc taattcccag ccactgcccc gcctcaggtc atcctcctgg     6540

cggtcagagt gacctactcg actggcactt ctggtgtgta ggaatctctg gtagatcaag     6600

ttaaaaggca gattttgaat ccctggatct ggggtggggc ctgaaattct gcatttctga     6660

ggggctccca ggtaaggcca aggctgctgg ccggctgagg agttaacagt gtgtgctctg     6720

gagtcacgtg gattcctgct tgccagtagc gcgccttgga aagtcacccc gcctggctct     6780

gccatttcct tctctgtaca tacagtgttg tctgcggtga gggtgacaca gctgaatagg     6840

cacaatgggc cggaccagtg ccgggcacgc ggtgcatgcg aagtcagtag ttataactgc     6900

tcgtctgtgc tgcaaccctg cagtgcaccc ttcgcctgca caataaaatc taccatcagc     6960

caccaccgtg ccctgccctc ccgtgcacca gtcaccctga gcattgtacg ggagttctgg     7020

aaaggagcag agttttctca aatgcagagt tgcccttgat tttgaatgcc gttctctccc     7080

tgatcccccc agcaaagtcc tcctccttct tttgggctct gagacctcca gagccacctc     7140

caggaagctg agaagacagg aagtgttttt actcttttcc attcccagtt ttgtacatca     7200

cctgacgtat actaggtttt aataaatggt gaaagaatga atgaaacaac aaatacttta     7260

ggtctttctt ctacaacttc tttggctgtg ttctacctag agaggctgaa tcttgactgc     7320

tcatcagtgc tttttaagaa atcaaggcca ggcgcagtgg ctcacaccag taatcacagt     7380

acttcgggag gccaagtggg gaggattgct tgattgagct caagagttca agacaagcct     7440

gggcaacatg gtgagaccct gtgtctacaa aaaaaaaatt taaaaattag ccagacacag     7500

tagtgtagtc ccagctactc aggaggctga ggcaggagga tttcttgagc ctgggaggtc     7560

aaggctgcag tgagccatga ttgtgccact gcactcctgc ctgggtgata gaatgacaca     7620

ttgcctcaaa aaaaaaaaaa aaaaaaaaaa ggaaagaaag aagaaaagaa aaatagaaac     7680

attcacttcc taaaatactg cctcaacata tctcattcca gacctatttt aagaggtgag     7740

tctccaatgt ggacttttat ttagcaagaa catttgcttg tttatttact tgtttatgta     7800

gttatgtcag tatgacttta tacattctta ttttattcaa tgctttataa tcc            7853


<210>  1100
<211>  123
<212>  PRT
<213>  Homo Sapiens

<400>  1100

Met Ser Leu Pro Pro Cys Ala Pro Gly His His Gly Glu Ser Arg Phe 
1               5                   10                  15      


Phe Thr Phe Lys Ser Met Thr Val Ala Gly Gln Gly Asp Ser Asp Thr 
            20                  25                  30          


Ala Ala Ile Ser Arg Glu Pro Val Ala Cys Leu Leu Cys Val Leu Pro 
        35                  40                  45              


His Trp Pro Pro Thr Cys Gln Leu Val Leu Pro Ala Ser Leu Thr Pro 
    50                  55                  60                  


Ala Ala Gly Val Ala Ala Ser Ala Gly Gly Ala Glu Ser Ser Lys Trp 
65                  70                  75                  80  


Leu Glu Gln Pro Arg Glu Gly Gly Asp Pro Trp Glu Ala Arg Ser Glu 
                85                  90                  95      


Phe Thr Trp Arg Thr Leu Glu Pro Gln Lys His Val Cys Leu Trp Gln 
            100                 105                 110         


Pro His Gly Ser Thr Ala Gly Val Asn Asp Pro 
        115                 120             


<210>  1101
<211>  2221
<212>  DNA
<213>  Homo Sapiens

<400>  1101
ggccaggaac gccagccgtt cacgcgttcg gtcctccttg gctgactcac cgccctggcc       60

gccgcaccat ggacgccccc aggcaggtgg tcaactttgg gcctggtccc gccaagctgc      120

cgcactcagt gttgttagag atacaaaagg aattattaga ctacaaagga gttggcatta      180

gtgttcttga aatgagtcac aggtcatcag attttgccaa gattattaac aatacagaga      240

atcttgtgcg ggaattgcta gctgttccag acaactataa ggtgattttt ctgcaaggag      300

gtgggtgcgg ccagttcagt gctgtcccct taaacctcat tggcttgaaa gcaggaaggt      360

gtgctgacta tgtggtgaca ggagcttggt cagctaaggc cgcagaagaa gccaagaagt      420

ttgggactat aaatatcgtt caccctaaac ttgggagtta tacaaaaatt ccagatccaa      480

gcacctggaa cctcaaccca gatgcctcct acgtgtatta ttgcgcaaat gagacggtgc      540

atggtgtgga gtttgacttt atacccgatg tcaagggagc agtactggtt tgtgacatgt      600

cctcaaactt cctgtccaag ccagtggatg tttccaagtt tggtgtgatt tttgctggtg      660

cccagaagaa tgttggctct gctggggtca ccgtggtgat tgtccgtgat gacctgctgg      720

ggtttgccct ccgagagtgc ccctcggtcc tggaatacaa ggtgcaggct ggaaacagct      780

ccttgtacaa cacgcctcca tgtttcagca tctacgtcat gggcttggtt ctggagtgga      840

ttaaaaacaa tggaggtgcc gcggccatgg agaagcttag ctccatcaaa tctcaaacaa      900

tttatgagat tattgataat tctcaaggat tctacgtttg tccagtggag ccccaaaata      960

gaagcaagat gaatattcca ttccgcattg gcaatgccaa aggagatgat gctttagaaa     1020

aaagatttct tgataaagct cttgaactca atatgttgtc cttgaaaggg cataggtctg     1080

tgggaggcat ccgggcctct ctgtataatg ctgtcacaat tgaagacgtt cagaagctgg     1140

ccgccttcat gaaaaaattt ttggagatgc atcagctatg aacacatcct aaccaggata     1200

tactctgttc ttgaacaaca tacaaagttt aaagtaactt ggggatggct acaaaaagtt     1260

aacacagtat ttttctcaaa tgaacatgtt tattgcagat tcttcttttt tgaaagaaca     1320

acagcaaaac atccacaact ctgtaaagct ggtgggacct aatgtcacct taattctgac     1380

ttgaactgga agcattttaa gaaatcttgt tgcttttcta acaaattccc gcgtattttg     1440

cctttgctgc tactttttct agttagattt caaacttgcc tgtggactta ataatgcaag     1500

ttgcgattaa ttatttctgg agtcatggga acacacagca cagagggtag gggggccctc     1560

taggtgctga atctacacat ctgtggggtc tcctgggttc agcggctgtt gattcaaggt     1620

caacattgac cattggagga gtggtttaag agtgccaggc gaagggcaaa ctgtagatcg     1680

atctttatgc tgttattaca ggagaagtga catactttat atatgtttat attagcaagg     1740

tctgttttta ataccatata ctttatattt ctatacattt atatttctaa taatacagtt     1800

atcactgata tatgtagaca cttttagaat ttattaaatc cttgaccttg tgcattatag     1860

cattccatta gcaagagttg taccccctcc ccagtcttcg ccttcctctt tttaagctgt     1920

tttatgaaaa agacctagaa gttcttgatt catttttacc attctttcca taggtagaag     1980

agaaagttga ttggttggtt gtttttcaat tatgccatta aactaaacat ttctgttaaa     2040

ttaccctatc ctttgttctc tactgttttc tttgtaatgt atgactacga gagtgatact     2100

ttgctgaaaa gtctttcccc tattgtttat ctattgtcag tattttatgt tgaatatgta     2160

aagaacatta aagtcctaaa acatctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2220

a                                                                     2221


<210>  1102
<211>  370
<212>  PRT
<213>  Homo Sapiens

<400>  1102

Met Asp Ala Pro Arg Gln Val Val Asn Phe Gly Pro Gly Pro Ala Lys 
1               5                   10                  15      


Leu Pro His Ser Val Leu Leu Glu Ile Gln Lys Glu Leu Leu Asp Tyr 
            20                  25                  30          


Lys Gly Val Gly Ile Ser Val Leu Glu Met Ser His Arg Ser Ser Asp 
        35                  40                  45              


Phe Ala Lys Ile Ile Asn Asn Thr Glu Asn Leu Val Arg Glu Leu Leu 
    50                  55                  60                  


Ala Val Pro Asp Asn Tyr Lys Val Ile Phe Leu Gln Gly Gly Gly Cys 
65                  70                  75                  80  


Gly Gln Phe Ser Ala Val Pro Leu Asn Leu Ile Gly Leu Lys Ala Gly 
                85                  90                  95      


Arg Cys Ala Asp Tyr Val Val Thr Gly Ala Trp Ser Ala Lys Ala Ala 
            100                 105                 110         


Glu Glu Ala Lys Lys Phe Gly Thr Ile Asn Ile Val His Pro Lys Leu 
        115                 120                 125             


Gly Ser Tyr Thr Lys Ile Pro Asp Pro Ser Thr Trp Asn Leu Asn Pro 
    130                 135                 140                 


Asp Ala Ser Tyr Val Tyr Tyr Cys Ala Asn Glu Thr Val His Gly Val 
145                 150                 155                 160 


Glu Phe Asp Phe Ile Pro Asp Val Lys Gly Ala Val Leu Val Cys Asp 
                165                 170                 175     


Met Ser Ser Asn Phe Leu Ser Lys Pro Val Asp Val Ser Lys Phe Gly 
            180                 185                 190         


Val Ile Phe Ala Gly Ala Gln Lys Asn Val Gly Ser Ala Gly Val Thr 
        195                 200                 205             


Val Val Ile Val Arg Asp Asp Leu Leu Gly Phe Ala Leu Arg Glu Cys 
    210                 215                 220                 


Pro Ser Val Leu Glu Tyr Lys Val Gln Ala Gly Asn Ser Ser Leu Tyr 
225                 230                 235                 240 


Asn Thr Pro Pro Cys Phe Ser Ile Tyr Val Met Gly Leu Val Leu Glu 
                245                 250                 255     


Trp Ile Lys Asn Asn Gly Gly Ala Ala Ala Met Glu Lys Leu Ser Ser 
            260                 265                 270         


Ile Lys Ser Gln Thr Ile Tyr Glu Ile Ile Asp Asn Ser Gln Gly Phe 
        275                 280                 285             


Tyr Val Cys Pro Val Glu Pro Gln Asn Arg Ser Lys Met Asn Ile Pro 
    290                 295                 300                 


Phe Arg Ile Gly Asn Ala Lys Gly Asp Asp Ala Leu Glu Lys Arg Phe 
305                 310                 315                 320 


Leu Asp Lys Ala Leu Glu Leu Asn Met Leu Ser Leu Lys Gly His Arg 
                325                 330                 335     


Ser Val Gly Gly Ile Arg Ala Ser Leu Tyr Asn Ala Val Thr Ile Glu 
            340                 345                 350         


Asp Val Gln Lys Leu Ala Ala Phe Met Lys Lys Phe Leu Glu Met His 
        355                 360                 365             


Gln Leu 
    370 


<210>  1103
<211>  5392
<212>  DNA
<213>  Homo Sapiens

<400>  1103
agccggagct ggagccgagg cggcggcggg acgcggccgg ccggacaaat ttcctgctag       60

gctgcggaca gcgggcggca ggagccggcg cgagcggctt caggaaccca cggcctctgc      120

gcgtccccgc gacccttctt cgcgcccggc gaagacagcc gggcgccccg gagggcggcg      180

ggcaggcgcc cgggagatgc ggagcctccg ctgcagcgcg atctgcgcga ccagaccggc      240

ccccccgaga ctatagcctt cactttccct cggtccacca tggagccctt gtgtccactc      300

ctgctggtgg gttttagctt gccgctcgcc agggctctca ggggcaacga gaccactgcc      360

gacagcaacg agacaaccac gacctcaggc cctccggacc cgggcgcctc ccagccgctg      420

ctggcctggc tgctactgcc gctgctgctc ctcctcctcg tgctccttct cgccgcctac      480

ttcttcaggt tcaggaagca gaggaaagct gtggtcagca ccagcgacaa gaagatgccc      540

aacggaatct tggaggagca agagcagcaa agggtgatgc tgctcagcag gtcaccctca      600

gggcccaaga agtattttcc catccccgtg gagcacctgg aggaggagat ccgtatcaga      660

tccgccgacg actgcaagca gtttcgggag gagttcaact cattgccatc tggacacata      720

caaggaactt ttgaactggc aaataaagaa gaaaacagag aaaaaaacag atatcccaac      780

atccttccca atgaccattc tagggtgatt ctgagccaac tggatggaat tccctgttca      840

gactacatca atgcttccta catagatggt tacaaagaga agaataaatt catagcagct      900

caaggtccca aacaggaaac ggttaacgac ttctggagaa tggtctggga gcaaaagtct      960

gcgaccatcg tcatgttaac aaacttgaaa gaaaggaaag aggaaaagtg ccatcagtac     1020

tggcccgacc aaggctgctg gacctatgga aacatccggg tgtgcgtgga ggactgcgtg     1080

gttttggtcg actacaccat ccggaagttc tgcatacagc cacagctccc cgacggctgc     1140

aaagccccca ggctggtctc acagctgcac ttcaccagct ggcccgactt cggagtgcct     1200

tttaccccca ttgggatgct gaagttcctc aagaaagtaa agacgctcaa ccccgtgcac     1260

gctgggccca tcgtggtcca ctgtagcgcg ggcgtgggcc ggacgggcac cttcattgtg     1320

atcgatgcca tgatggccat gatgcacgcg gagcagaagg tggatgtgtt tgaatttgtg     1380

tctcgaatcc gtaatcagcg ccctcagatg gttcaaacgg atatgcagta cacgttcatc     1440

taccaagcct tactcgagta ctacctctac ggggacacag agctggacgt gtcctccctg     1500

gagaagcacc tgcagaccat gcacggcacc accacccact tcgacaagat cgggctggag     1560

gaggagttca ggaaattgac aaatgtccgg atcatgaagg agaacatgag gacgggcaac     1620

ttgccggcaa acatgaagaa ggccagggtc atccagatca tcccgtatga cttcaaccga     1680

gtgatccttt ccatgaaaag gggtcaagaa tacacagact acatcaacgc atccttcata     1740

gacggctacc gacagaagga ctatttcatc gccacccagg ggccactggc acacacggtt     1800

gaggacttct ggaggatgat ctgggaatgg aaatcccaca ctatcgtgat gctgacggag     1860

gtgcaggaga gagagcagga taaatgctac cagtattggc caaccgaggg ctcagttact     1920

catggagaaa taacgattga gataaagaat gatacccttt cagaagccat cagtatacga     1980

gactttctgg tcactctcaa tcagccccag gcccgccagg aggagcaggt ccgagtagtg     2040

cgccagtttc acttccacgg ctggcctgag atcgggattc ccgccgaggg caaaggcatg     2100

attgacctca tcgcagccgt gcagaagcag cagcagcaga caggcaacca ccccatcacc     2160

gtgcactgca gtgccggagc tgggcgaaca ggtacattca tagccctcag caacattttg     2220

gagcgagtaa aagccgaggg acttttagat gtatttcaag ctgtgaagag tttacgactt     2280

cagagaccac atatggtgca aaccctggaa cagtatgaat tctgctacaa agtggtacaa     2340

gattttattg atatattttc tgattatgct aatttcaaat gaagattcct gccttaaaat     2400

attttttaat ttaatggtca gtatattttg taaaaatcat gttaatttat ttcatagttg     2460

acattaatat cttccctaat ttctttgtat atattttgtt atgccttaaa ggccacctgc     2520

tatacagttg ttaaatctta aatatgcttt ttaaaaattg gaataatgta ttaaggtcaa     2580

ataatatccc ataaaatata tatttctgct aatattagta aatatcttaa tttttcatta     2640

gattcatatc atttaatttc acatattcaa cacctttaaa tgttgtaatc ttaatatgcg     2700

aagtgtgcct ctgcaagata ctaacacaaa gctcatgtta agaaaacagt tgaggactca     2760

gaagtcagtt cgaaaatgca ctttcctaac agtgaattca caaccctgaa cagcagcatt     2820

tttggaaggc aaactgttcg tgatggtaca atgtaaatgg ggacttctgt aaagttctca     2880

gtttcggtcc atgtggttta tctttacatt ttaaagatca aagaagtctt tacaacctga     2940

atccaggtct aaaacacact agagtagctg gtgactataa ataatatttt aaaatgctgt     3000

gtctacacca tcaagactgt gtctacacta tcttggctga acgagaagag atgtaaatgc     3060

tgggtggtcc cgttgaccca cggcgttggg tacaacaaaa ccagccatcg gagttacacc     3120

ccaaagcacc atttgctgtc cagctgcctg tcgtttggcc cagaccaccc tcagaaaaaa     3180

accagctgcc tctcccattc tcccctcccg ttctgccaca gcggcctggg ctggtccagt     3240

gctatgcctg gaggctcaac acaaaacttc ccatccaaac attcagatga actgagcgtc     3300

ttacacacgc agtacagagg agcacacatt aggatagaaa cagtagaata accacgggca     3360

attaaacttt aaattttctg agcagcattt tggtatttaa acatttcttg taaaaagctg     3420

agacagtttg taagaaaaga atccttaaaa tctagattta taccattttt taaagtccca     3480

cctttcaatg tttaataaaa caaaaagaga aatccttaat ctaaaagcta aattattttt     3540

gaatggaaat actactgaga ccattgacac tggataacag taatgatccc attaccagat     3600

aagattgact gacggggaaa aaaaaaaaaa aagaatgggg tgtgaatgta ccaacactga     3660

atcttacagc agttatcttt ctatggccat taggtaccta gcagatgtgc acaatataaa     3720

caaaaagata tctggcctac cttactacta aaagcattta acacgtgcat ttttggtact     3780

tttttttttg ttttctaaaa gctacataaa ggccttattt gacattttca ctgataactg     3840

atcgcaccct catgttgcag tgttcgtccc ctattcatta acagtgtgtg caaatgcaac     3900

cccaggacac attattgttc tgatagatgc tcacagggaa tcaagcttct cgcccactcc     3960

acggctctga gccccatcca agggcaagac ttggtgccca gctggaagga cgaaagcaca     4020

ctttgtgacc gccatcctca ccagctgcat gcctgggctg cacactgctg aacgtgctcc     4080

tctctccttc tctgtacaat gattcagcat ctcggcggaa gaggaaaatg gagctttttg     4140

aggctcgcca ggtccctttt gttttcacca ttaaaattcc aaacccaaag cctttgtttg     4200

actgaaggag aagagaggga agtaagcttc tgttcagcac ctgaacccta gaaaaagagc     4260

cagtttgcta cgatgaaggt gacatttctc tggtcattta tttgagagtt cgaagtcaaa     4320

gtcgaggggc accggctttg gttcatgtct aggagccctc tgtcagaatc cttgaagccc     4380

tttaatggtc taactggcat ctcttgtatc aagaagtacc tttaaggtag accttttcag     4440

ggtgccctca ggaaagggcc ctgctcatgt ttttttcctg tccccttaga ccaaccccag     4500

gtgtccactg caggggttct gcctgttccc aaactttttc cattccagga acaaaggaga     4560

agccactttc cccaggacgc aagactctcc cctccactgt ccgggacagc gttcgccctt     4620

tagcggggag gtcattacag cctcatggcc tctaccaagg ccccagatca caggatctcc     4680

tgggccttgg agcacctcac gctgggggaa tcaatccctg agggactcag aatcttctcc     4740

gtgcaacctg gaaagttcat ctcttgtttc cttcagtcaa agaaagtcca ttgtacataa     4800

caaaacagcc cccaaacagc ccagtgccga caccattgtt cctttcacac tttcctttgt     4860

tgcatgcagt tgggttcaaa tgccaaatag tgattagaag acgaccattc tgatctgtgt     4920

gtgatctggt cactatgtga ctgcctttac ggtttctctc catgtgctat atgaatgaag     4980

aatgcatacc agtgttttaa aaggtatttt tatgtgtttt taaacacttt tttaaatgag     5040

cctgacacct gtgtttcagc atttggagac atccccatgt tattctttta agtgtataat     5100

tactgatact tttttgtttg tttgtttaac taagttgtgt ttaacttatg tgcagtcttt     5160

ataatgtatg tatgttatta cagtttcaac tatcatattt tctttgatta catttataat     5220

ttgatcttgc tctgattata atgccagtga atgttgctga actctttgta tatgcaaatt     5280

gcaagattta aaccattctg atgcaaggat aaacctttac tttgactacc agcctgtgtt     5340

tttgtcttta aatctcttaa tttcattcct ctgcaaaaaa aaaaaaaaaa aa             5392


<210>  1104
<211>  700
<212>  PRT
<213>  Homo Sapiens

<400>  1104

Met Glu Pro Leu Cys Pro Leu Leu Leu Val Gly Phe Ser Leu Pro Leu 
1               5                   10                  15      


Ala Arg Ala Leu Arg Gly Asn Glu Thr Thr Ala Asp Ser Asn Glu Thr 
            20                  25                  30          


Thr Thr Thr Ser Gly Pro Pro Asp Pro Gly Ala Ser Gln Pro Leu Leu 
        35                  40                  45              


Ala Trp Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Val Leu Leu Leu 
    50                  55                  60                  


Ala Ala Tyr Phe Phe Arg Phe Arg Lys Gln Arg Lys Ala Val Val Ser 
65                  70                  75                  80  


Thr Ser Asp Lys Lys Met Pro Asn Gly Ile Leu Glu Glu Gln Glu Gln 
                85                  90                  95      


Gln Arg Val Met Leu Leu Ser Arg Ser Pro Ser Gly Pro Lys Lys Tyr 
            100                 105                 110         


Phe Pro Ile Pro Val Glu His Leu Glu Glu Glu Ile Arg Ile Arg Ser 
        115                 120                 125             


Ala Asp Asp Cys Lys Gln Phe Arg Glu Glu Phe Asn Ser Leu Pro Ser 
    130                 135                 140                 


Gly His Ile Gln Gly Thr Phe Glu Leu Ala Asn Lys Glu Glu Asn Arg 
145                 150                 155                 160 


Glu Lys Asn Arg Tyr Pro Asn Ile Leu Pro Asn Asp His Ser Arg Val 
                165                 170                 175     


Ile Leu Ser Gln Leu Asp Gly Ile Pro Cys Ser Asp Tyr Ile Asn Ala 
            180                 185                 190         


Ser Tyr Ile Asp Gly Tyr Lys Glu Lys Asn Lys Phe Ile Ala Ala Gln 
        195                 200                 205             


Gly Pro Lys Gln Glu Thr Val Asn Asp Phe Trp Arg Met Val Trp Glu 
    210                 215                 220                 


Gln Lys Ser Ala Thr Ile Val Met Leu Thr Asn Leu Lys Glu Arg Lys 
225                 230                 235                 240 


Glu Glu Lys Cys His Gln Tyr Trp Pro Asp Gln Gly Cys Trp Thr Tyr 
                245                 250                 255     


Gly Asn Ile Arg Val Cys Val Glu Asp Cys Val Val Leu Val Asp Tyr 
            260                 265                 270         


Thr Ile Arg Lys Phe Cys Ile Gln Pro Gln Leu Pro Asp Gly Cys Lys 
        275                 280                 285             


Ala Pro Arg Leu Val Ser Gln Leu His Phe Thr Ser Trp Pro Asp Phe 
    290                 295                 300                 


Gly Val Pro Phe Thr Pro Ile Gly Met Leu Lys Phe Leu Lys Lys Val 
305                 310                 315                 320 


Lys Thr Leu Asn Pro Val His Ala Gly Pro Ile Val Val His Cys Ser 
                325                 330                 335     


Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ala Met Met 
            340                 345                 350         


Ala Met Met His Ala Glu Gln Lys Val Asp Val Phe Glu Phe Val Ser 
        355                 360                 365             


Arg Ile Arg Asn Gln Arg Pro Gln Met Val Gln Thr Asp Met Gln Tyr 
    370                 375                 380                 


Thr Phe Ile Tyr Gln Ala Leu Leu Glu Tyr Tyr Leu Tyr Gly Asp Thr 
385                 390                 395                 400 


Glu Leu Asp Val Ser Ser Leu Glu Lys His Leu Gln Thr Met His Gly 
                405                 410                 415     


Thr Thr Thr His Phe Asp Lys Ile Gly Leu Glu Glu Glu Phe Arg Lys 
            420                 425                 430         


Leu Thr Asn Val Arg Ile Met Lys Glu Asn Met Arg Thr Gly Asn Leu 
        435                 440                 445             


Pro Ala Asn Met Lys Lys Ala Arg Val Ile Gln Ile Ile Pro Tyr Asp 
    450                 455                 460                 


Phe Asn Arg Val Ile Leu Ser Met Lys Arg Gly Gln Glu Tyr Thr Asp 
465                 470                 475                 480 


Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Lys Asp Tyr Phe 
                485                 490                 495     


Ile Ala Thr Gln Gly Pro Leu Ala His Thr Val Glu Asp Phe Trp Arg 
            500                 505                 510         


Met Ile Trp Glu Trp Lys Ser His Thr Ile Val Met Leu Thr Glu Val 
        515                 520                 525             


Gln Glu Arg Glu Gln Asp Lys Cys Tyr Gln Tyr Trp Pro Thr Glu Gly 
    530                 535                 540                 


Ser Val Thr His Gly Glu Ile Thr Ile Glu Ile Lys Asn Asp Thr Leu 
545                 550                 555                 560 


Ser Glu Ala Ile Ser Ile Arg Asp Phe Leu Val Thr Leu Asn Gln Pro 
                565                 570                 575     


Gln Ala Arg Gln Glu Glu Gln Val Arg Val Val Arg Gln Phe His Phe 
            580                 585                 590         


His Gly Trp Pro Glu Ile Gly Ile Pro Ala Glu Gly Lys Gly Met Ile 
        595                 600                 605             


Asp Leu Ile Ala Ala Val Gln Lys Gln Gln Gln Gln Thr Gly Asn His 
    610                 615                 620                 


Pro Ile Thr Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Thr Phe 
625                 630                 635                 640 


Ile Ala Leu Ser Asn Ile Leu Glu Arg Val Lys Ala Glu Gly Leu Leu 
                645                 650                 655     


Asp Val Phe Gln Ala Val Lys Ser Leu Arg Leu Gln Arg Pro His Met 
            660                 665                 670         


Val Gln Thr Leu Glu Gln Tyr Glu Phe Cys Tyr Lys Val Val Gln Asp 
        675                 680                 685             


Phe Ile Asp Ile Phe Ser Asp Tyr Ala Asn Phe Lys 
    690                 695                 700 


<210>  1105
<211>  5426
<212>  DNA
<213>  Homo Sapiens

<400>  1105
ggggaggaag aaaggcgaag gcaaggcgaa ggggtggaga gtgatatgaa gagcgagaga       60

aaagagagga cagcggacga gcagatccgg tatctggaat cccggcgcct agaacgtgtt      120

tttcgggaga gcaaaggctg tgtctacggc agcctgggga tatagcctct ccttccgatg      180

aaaagagaaa ggaagaatgg actacagcca ccaaacgtcc ctagtcccat gtggacaaga      240

taaatacatt tccaaaaatg aacttctctt gcatctgaag acctacaact tgtactatga      300

aggccagaat ttacagctcc ggcaccggga ggaagaagac gagttcattg tggaggggct      360

cctgaacatc tcctggggcc tgcgccggcc cattcgcctg cagatgcagg atgacaacga      420

acgcattcga ccccctccat cctcctcctc ctggcactct ggctgtaacc tgggggctca      480

gggaaccact ctgaagcccc tgactgtgcc caaagttcag atctcagagg tggatgcccc      540

gccggagggt gaccagatgc caagctccac agactccagg ggcctgaagc ccctgcagga      600

ggacacccca cagctgatgc gcacacgcag tgatgttggg gtgcgtcgcc gtggcaatgt      660

gaggacgcct agtgaccagc ggcgaatcag acgccaccgc ttctccatca acggccattt      720

ctacaaccat aagacatccg tgttcacacc agcctatggc tctgtcacca acgtccgcat      780

caacagcacc atgaccaccc cacaggtcct gaagctgctg ctcaacaaat ttaagattga      840

gaattcagca gaggagtttg ccttgtacgt ggtccatacg agtggtgaga aacagaagct      900

gaaggccacc gattacccgc tgattgcccg aatcctccag ggcccatgtg agcagatctc      960

caaagtgttc ctaatggaga aggaccaggt ggaggaagtc acctacgacg tggcccagta     1020

tataaagttc gagatgccgg tacttaaaag cttcattcag aagctccagg aggaagaaga     1080

tcgggaagta aagaagctga tgcgcaagta caccgtgctc cggctaatga ttcgacagag     1140

gctggaggag atagccgaga ccccagcaac aatctgagcc atgagaacga ggggatctgg     1200

gcaccccagg aaccgccatt gcccataaga cccccaggaa gctaggcact ttctttccat     1260

ggaaacattt agacacaaac ctccccagct ccggccaagc catcatttgc tacctggagc     1320

tggatgtaga agtcagcaga cagctcccta tccctggacc cctgccctcc ttttttctgc     1380

tcacaaggac ttttgatttt agttataagg aggacccaaa atgtgtgtgt gtacatgtgt     1440

gtgcacacat ggtacgtgtc catgtgccta cctgatactt tcacatgtaa ttaaattcca     1500

ggcaaccagc acaagagccg tgagcttggc acatgtgctg ctcgtgagca ggaaaatcag     1560

aggagccact gatctgagtg gtatttaggt tgaaggaaag atttctcctc tcaagtgcca     1620

gggagcagcc acacgtctgt ctgtgtttag agagggaaga gggttctcca ggttcaccat     1680

ttgggttgtt tatatgttgg tagaaattct ccctgtatgc ctagaaggat cagtgaatgt     1740

aagagccttg gaaattaaca aaataacagc cacataacct tgcggcaagt ctgatggaaa     1800

gaaaaagata aaccatccgt ggggtagatg caataagccc acgtattttt acactggaaa     1860

cgttgattgt tttaaatgac aaagacatat gtgatgttct atgtggaaac ctgtgaagag     1920

tggattctgc ctccatctct gcctccatgg ctacctttag gagacagaga agatcctgtg     1980

tgtttctctg tacccagctg acagcctgtc tctatggcgc ttccttgagt ggaaggaaat     2040

gtctcaagaa acaaagatct cgctggtgcg tacacagtgc tgaccagcta gtgtggccag     2100

ggcctggtgg cctggtggcc aggaagtttc aggttgaagg gaaatgtcga ggctacctgc     2160

agatatgaca ggtgccttga acgcagccca tcttcatgtc atcaaaggtc ttcctgcact     2220

tgaagctggg gcgatgtttg cagtcaagac cattctttcc aacctctggg ttcttgcaag     2280

ttgccctcac cttgtgtgtg gagatgcatt ccaagaatga agcctcatct tgctactgag     2340

tgtggggttc agggaagctc tttaggccac ctggtgaagg tgcatgggga ggatggagct     2400

tctcctcagc tcctctgagc agccacctat gtgatcttta aatccaaccc caatgggaga     2460

aaagggcaag aacagtctgt gccctgggac tcctatcagg aagcttgaca ggcagctggg     2520

catcagtgca gctgatatcg tttgaggagg gagacagatg cttggacctg ggtgcctggc     2580

tatggagatt gaccaagcaa gatcaggagc tcctgatagc aggcgtcttt gagcctagct     2640

ggggtagagg cactgcccat ctcttctcca ccttctctcc acagaatgtt tgcagagctg     2700

ggcagttgag gaaaggacag cccctggttg gtgcctccaa aggaaggtgg acttttttgg     2760

tggagacgtt tctgccctgg gcaccctcct gcccccgatt catacctatg gcttcttgag     2820

aaggctcaca gctgtggtct taacgtagac tgcagaaaga tggcatgcgg cccctggcat     2880

ttcgccaagg gttttatagc aagtctcctt cctccatagg gacagcagca ccagccctgt     2940

ggggcatgga gtggaagccc agaagggctt ctgcaagctg cacagaactg gggtaagaag     3000

acaaagagta gccaccggga gaggcttcct ttgttacagc tgggaaagaa cagttctgtg     3060

aatgcaaaca cctcctgagt tttgcaattg agaaaatgat ttggagaact tctcttctgg     3120

taatttttat tttgaatgtt cagggcctta gttggcccca gtaattctcc ttggaggact     3180

tgggagaaga atttccacaa agcaaactac taaccactag ctcttactgg acagcgattt     3240

ctggcttata agagttctct ttgatttgca ctagcactac gatagtgtta gatggggaaa     3300

tactgcaaca tgtccagttg gccagatcac tttccaaggg agcgatacta aggcagactc     3360

agctttttaa agatgggagg tcaggaggtg gaagtgagag gagatcccat ctcacacaac     3420

acacttccac gtaatgcaga ccacactttt ccattttgtc ctgccctctt gagaggtcat     3480

ttctcacgtc ctaagaacct gatcagaaat tttggaaggg ttctttgaaa tagcagcagt     3540

tgaaacagag acactttgcc acagtgtgga gcagattttc tcactggtat cacatggtct     3600

tgcagttttg aactcttcga ccgatttgtg ggagtttatg taattgcgtg caatgaacct     3660

gaaattgtgt aaaggacaaa agaccagttt atagggttgg gttttttttc caacttgtga     3720

aaagcagttt agctgcatct gtctccccac cacccccacc ccgggagggg cttatgttac     3780

aaggtgatca agtgaaggaa aaacctgagc ctatctggct gggatggtgg aattaagcac     3840

aaggtcacat tctctgtgat cacatgagag ggaaggtgat gacttaaatg gcagggggtg     3900

gggattatct tggggagagg ctgaaaagca caaaagatag tcttccctgt acgtattggt     3960

gaagaacgtg cacaaggctg gatggacttc aacttggagt tgagttgagg caagaggatt     4020

tctggatatt agtcacccat ctgcaagaaa aatgctgagg cctcgggtca agattttgat     4080

ctgagacatg ctgatgcttc aaggagaaat attttcacaa tcctctcttc cctcaccaga     4140

agagaacagt actctctcct agaaacctct aggtaaacac attttatcct aatatcggta     4200

gcatataatg ccccccccaa aatatctgtt ttccatgcaa aaaagtctca acaagaagtc     4260

tgtggagttg agtggttact tcaaagtgtc aggagagtga agaaattggc cacagaagag     4320

caagaagctc tcttaagaaa agggaattct ctttaaagaa accaccacca acaacaaaac     4380

aaccaaaaac catgttttat gtcaaagctc tgtagcacag agaatgtggt gtcacagata     4440

catcgccgag agaggtttct ttctttcttt tttttttttt tgagacagag tctggttctg     4500

tttcccaggc tggagtgcag tggtgggatc tcagctcact gcaacatccg cctctggggt     4560

tcaagtgatt ctcctgtctc agcctcccaa gtagctggaa ttacagggac ccgccaccac     4620

gcccggctaa tttttttgtg tggttttagt agaggtgggg tttcaccatc ttggccaggc     4680

tggtcttgaa ctcctgacct cgtgatccac ccgcctaggc ctcccaaagt gttgggatta     4740

caggcgtgag ccactgtgcc cagccaaaag agaaatttct acatgaacaa ggcaatttca     4800

gtgtcttaca gcggccaaac catgacgtga agaatgagat aggagacagg agatcaccat     4860

aagcgtccct gatatagcag cacacatttt cacgtttcca cttaaatcgt tttgcacaaa     4920

gtcttgcttc gctcagatga gatgagatat gatttcctag agatgtaaaa ataagaatga     4980

atgtggcgcc cccttcttcc agatgtaata gaaagctctg ccctatcaca aggggggtgt     5040

tgaagcgccc cttgtgtttt aactgtattt aactgagcac aagatgcaca agctgtggtg     5100

ggaaaccctc agtttacctt tggagtcttc cctgcagatc gcagacctgt ttccaggctg     5160

atgtttctgg tgtgtaattg ctagcgtttc tgaagggttt tcccaattgt tttagccttg     5220

tgaagtattc ttaattataa cttgcctttc agcgatggta catgacttga ttcaacgttt     5280

ggttctgaac ttacacactg atgcgtttac tcatctaaca taatctgaca gggcctcagc     5340

aagggagcca tacatttttg taacattttg atatgtttta atgcatctga cttagatctt     5400

actgaaataa agcacttttc aaagag                                          5426


<210>  1106
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  1106

Met Asp Tyr Ser His Gln Thr Ser Leu Val Pro Cys Gly Gln Asp Lys 
1               5                   10                  15      


Tyr Ile Ser Lys Asn Glu Leu Leu Leu His Leu Lys Thr Tyr Asn Leu 
            20                  25                  30          


Tyr Tyr Glu Gly Gln Asn Leu Gln Leu Arg His Arg Glu Glu Glu Asp 
        35                  40                  45              


Glu Phe Ile Val Glu Gly Leu Leu Asn Ile Ser Trp Gly Leu Arg Arg 
    50                  55                  60                  


Pro Ile Arg Leu Gln Met Gln Asp Asp Asn Glu Arg Ile Arg Pro Pro 
65                  70                  75                  80  


Pro Ser Ser Ser Ser Trp His Ser Gly Cys Asn Leu Gly Ala Gln Gly 
                85                  90                  95      


Thr Thr Leu Lys Pro Leu Thr Val Pro Lys Val Gln Ile Ser Glu Val 
            100                 105                 110         


Asp Ala Pro Pro Glu Gly Asp Gln Met Pro Ser Ser Thr Asp Ser Arg 
        115                 120                 125             


Gly Leu Lys Pro Leu Gln Glu Asp Thr Pro Gln Leu Met Arg Thr Arg 
    130                 135                 140                 


Ser Asp Val Gly Val Arg Arg Arg Gly Asn Val Arg Thr Pro Ser Asp 
145                 150                 155                 160 


Gln Arg Arg Ile Arg Arg His Arg Phe Ser Ile Asn Gly His Phe Tyr 
                165                 170                 175     


Asn His Lys Thr Ser Val Phe Thr Pro Ala Tyr Gly Ser Val Thr Asn 
            180                 185                 190         


Val Arg Ile Asn Ser Thr Met Thr Thr Pro Gln Val Leu Lys Leu Leu 
        195                 200                 205             


Leu Asn Lys Phe Lys Ile Glu Asn Ser Ala Glu Glu Phe Ala Leu Tyr 
    210                 215                 220                 


Val Val His Thr Ser Gly Glu Lys Gln Lys Leu Lys Ala Thr Asp Tyr 
225                 230                 235                 240 


Pro Leu Ile Ala Arg Ile Leu Gln Gly Pro Cys Glu Gln Ile Ser Lys 
                245                 250                 255     


Val Phe Leu Met Glu Lys Asp Gln Val Glu Glu Val Thr Tyr Asp Val 
            260                 265                 270         


Ala Gln Tyr Ile Lys Phe Glu Met Pro Val Leu Lys Ser Phe Ile Gln 
        275                 280                 285             


Lys Leu Gln Glu Glu Glu Asp Arg Glu Val Lys Lys Leu Met Arg Lys 
    290                 295                 300                 


Tyr Thr Val Leu Arg Leu Met Ile Arg Gln Arg Leu Glu Glu Ile Ala 
305                 310                 315                 320 


Glu Thr Pro Ala Thr Ile 
                325     


<210>  1107
<211>  2787
<212>  DNA
<213>  Homo Sapiens

<400>  1107
cctagtccca gcccaggggg ccgctctcgc cggcgtcgag ggcgtggcgg cgaggctgct       60

gctgcaggcg gctcccggct ctgccttcgg ccccgcccgc cgcccaccag gctcccagag      120

gccccgcagc tcgcgccgtc cggctccccg cagccccgtc gggcagcccg ggcccgtccg      180

ctgccctccc ggctcccgtc ctgcggcggc ggggcgtgca ggtgaggccc cacggcgccc      240

ggcctctcca gcagtgggtg cctgatagac atcctaggac tatacagaag gaaaaggccc      300

actttggggg ataatgctga gggacactat gaaatcttgg aatgatagcc agtcagatct      360

gtgtagcact gaccaagaag aggaagaaga gatgattttt ggtgaaaatg aagatgattt      420

ggatgagatg atggatttaa gtgatctgcc tacctcactt tttgcttgca gcgtccatga      480

agcagtgttt gaggcacgag agcagaagga aagatttgaa gcactcttca ccatctatga      540

tgaccaggtt acttttcagc tgtttaaaag ctttagaaga gtcagaataa atttcagcaa      600

acctgaagcg gcagcaagag cgcgaataga actccacgaa acagacttca atgggcagaa      660

gctaaagcta tattttgcac aggtgcagat gtccggcgaa gtgcgggaca agtcctatct      720

cctgccgccc cagcctgtca agcagttcct catctcccct ccagcctctc ccccggtggg      780

gtggaagcag agcgaagatg cgatgcctgt tataaattat gatttactct gtgctgtttc      840

caaattggga ccaggagaga aatatgaact tcacgcggga acagagtcga cacccagcgt      900

ggtggttcat gtctgtgaaa gtgaaactga agaggaagaa gagacaaaaa accccaaaca      960

gaaaattgcc cagacgaggc gccccgaccc tccgaccgca gcgttgaatg agccccagac     1020

ctttgattgc gcgctgtgag gcccttggtt gtggtgcgag gcggctgccc tggtgggctc     1080

tggccatggc gctctgtgcc tgcggccgat gcgttgctgc gaacagcata ggtgagactc     1140

tgccgagtga ggtataggtc ttctcaccac gcctgtactg cagacacggt cgtgtagagt     1200

agcagctgat ttgacctgtc ccagatttta agtgatattc caaaagggac tttacattaa     1260

aggagaagcc cccaagatgt ggccaccctt aaccattttt aaatagtaac aaattaggaa     1320

aacagctccc ctcccctcca gccatgtaag tcctcctgat tctgtatcac atgagacacc     1380

aaaaactgga aatgtagtca cacccagtac agtaccattt ttatgaattt aaaaatagtc     1440

ttataatttt aattgtttgt gggtattttt ctactggtat aaatagcttc taattaataa     1500

atcgatcaaa ggttgttact cagtatacat gaaatttttt gcaggaaaag aaaccagaaa     1560

tacagaataa ttcatagaaa tcatggttct caagtatttg ttcaattagc tttggggaag     1620

aaatgccaaa tccactttga ggatgagtct tacgacacag atccacccac atgttgctct     1680

tatctggaat ttgggacaaa gcaatgcaca ggccctcatt cctgatgtgg cgccctccag     1740

acatggctgc ccaggaagga cggccacttt agaagtggga cgtatcacca gtaagcttga     1800

atgattagga tcgcaggtgg ctactgcatt ctgccgttcg tgaccgtgtt ctagcctgta     1860

gaccacccag ctaccttcat tcaccagttt ttatccttca ccttttccag tatcttgtta     1920

accactagtt cttgagtttt ttggctatga tgtgtacgtt tatgtatgtc attcatggac     1980

tttcaactag aaaaggtaat gataaggttt tctgaagacc atttgtaaat tgtccattta     2040

accatttttc agcttgcttt gaaacaaaag tcacacctac tatttttcta tgaattaggg     2100

aatgaggggg agatcattca gttttacttt tctttttgtt gaaattttgt acccggattg     2160

cagttggcac ttttcctaaa acagaattgt ttcccactta ggtgtcagaa tgtacctttg     2220

aacttcccta agaagcagca ggatcttttt aactctctct ggtctgttta gactttgaag     2280

tcccttctgt agaaaagtct cataactgag aaggctctgt tttgggccgg gtgggtctgc     2340

tggcctccac tcactgtgct gtttcctttg agtggcacac ttgggaagct ccggggcatg     2400

tgaaggagct gcaaacatga gaactaatga accaaggcgg ctgccaccag gaaggaacag     2460

aacgcaggca ttcaaccatg acgtctgcac agtgttagta acatgtcatt gtggtttcgt     2520

tctcactgtg gtaaaattta tttctgagca cttaaactgt gttgcatacc cctaattttt     2580

tttttttctg tatcttcctt gccctcaaat accctgaggt gataaactgt tccagttgta     2640

gccaactacc actgctaggc ctcaatgtaa attcagttga aatttgcaat tctatcagca     2700

atttaatgta ttgaattcag atcatcattt gtcattttaa ccgacaacca cccaataaat     2760

ttactctgca gttctgaact caaaaaa                                         2787


<210>  1108
<211>  241
<212>  PRT
<213>  Homo Sapiens

<400>  1108

Met Leu Arg Asp Thr Met Lys Ser Trp Asn Asp Ser Gln Ser Asp Leu 
1               5                   10                  15      


Cys Ser Thr Asp Gln Glu Glu Glu Glu Glu Met Ile Phe Gly Glu Asn 
            20                  25                  30          


Glu Asp Asp Leu Asp Glu Met Met Asp Leu Ser Asp Leu Pro Thr Ser 
        35                  40                  45              


Leu Phe Ala Cys Ser Val His Glu Ala Val Phe Glu Ala Arg Glu Gln 
    50                  55                  60                  


Lys Glu Arg Phe Glu Ala Leu Phe Thr Ile Tyr Asp Asp Gln Val Thr 
65                  70                  75                  80  


Phe Gln Leu Phe Lys Ser Phe Arg Arg Val Arg Ile Asn Phe Ser Lys 
                85                  90                  95      


Pro Glu Ala Ala Ala Arg Ala Arg Ile Glu Leu His Glu Thr Asp Phe 
            100                 105                 110         


Asn Gly Gln Lys Leu Lys Leu Tyr Phe Ala Gln Val Gln Met Ser Gly 
        115                 120                 125             


Glu Val Arg Asp Lys Ser Tyr Leu Leu Pro Pro Gln Pro Val Lys Gln 
    130                 135                 140                 


Phe Leu Ile Ser Pro Pro Ala Ser Pro Pro Val Gly Trp Lys Gln Ser 
145                 150                 155                 160 


Glu Asp Ala Met Pro Val Ile Asn Tyr Asp Leu Leu Cys Ala Val Ser 
                165                 170                 175     


Lys Leu Gly Pro Gly Glu Lys Tyr Glu Leu His Ala Gly Thr Glu Ser 
            180                 185                 190         


Thr Pro Ser Val Val Val His Val Cys Glu Ser Glu Thr Glu Glu Glu 
        195                 200                 205             


Glu Glu Thr Lys Asn Pro Lys Gln Lys Ile Ala Gln Thr Arg Arg Pro 
    210                 215                 220                 


Asp Pro Pro Thr Ala Ala Leu Asn Glu Pro Gln Thr Phe Asp Cys Ala 
225                 230                 235                 240 


Leu 
    


<210>  1109
<211>  3012
<212>  DNA
<213>  Homo Sapiens

<400>  1109
gcgcagggcc cccgcggccg gggcagtccc gcagccgagc gcagccgggc gcgcgccacc       60

gcccactcgc cctgtgcccg ccgcagcccg aaactggcca cggccgggag cggaggggac      120

agcggggatc gtgagctccg gcccgggcga gcgggtgcgt ctgccgcaga gtcggcacct      180

gaaggacatg gaggaaagac cggcagagac caatgccaat gtggacaact cggcgtcccc      240

ctcggtggcc cagctggccg ggcggtttag ggagcaggcg gctgcagcca aggagacacc      300

agccagtaaa ccaacccgaa ggaaaccgcc ctgttccctc cccctgttcc cccccaaggt      360

agacctgggc cagaatggtg aggagaaatc accacccaat gcgagccacc ctcctaaatt      420

caaggtcaag agctcgcctc tgattgagaa gcttcaggcc aatttaacct ttgacccagc      480

tgctctactg cctggggcct cacccaagag tcctggactc aaggctatgg tgtcgccatt      540

tcacagccca ccttctaccc ccagcagccc tggtgtgcga tctaggccca gcgaggcaga      600

ggaggtgcct gtcagcttcg accagccccc tgaaggcagt catctgccct gttacaacaa      660

ggtgcggacg aggggctcaa taaaaaggcg ccctccctcc aggcgattcc gaaggtcaca      720

gtcagactgt ggagaacttg gagatttcag ggcggtggag tcatctcagc agaacggtgc      780

taaggaagag gatggggatg aagtgttgcc atccaagagc aaggccccag gatccccttt      840

gtccagtgag ggagcagcgg gagagggagt gagaaccctg ggacctgctg aaaagcctcc      900

tctgaggagg tcacccagca ggacagagaa gcaggaggag gacagggcca cagaggaagc      960

caagaacggt gaaaaggcca ggcggagttc agaggaggtg gacggccagc acccggccca     1020

agaggaggtc ccggaatcgc cccagacctc tggcccagag gcagaaaata ggtgtgggag     1080

ccccagggag gaaaagccag ctggagagga agcagagatg gaaaaggcta cagaggtgaa     1140

gggggagagg gtgcaaaatg aagaggtggg acctgaacat gacagccaag aaacaaagaa     1200

gctggaggag ggagctgcag tgaaggagac cccccacagt ccccctggag gagtgaaggg     1260

cggagatgtc cccaagcagg aaaaaggcaa ggaaaaacaa caggaggggg cagtgctcga     1320

gccaggctgc agcccccaga ccggccctgc ccagctggag accagcagtg aggtccagag     1380

cgagccagca gtccccaagc cggaggatga cactcctgtc caggacacta aaatgtgaag     1440

aacagctcat tgtgccccag tgatgaagtt gctggacaca tctctttgca ggtagcagca     1500

acagttgtag cagcagcaga cgaagccatt gcagaggcag aatatgctga gtgtctggag     1560

tcagcctgaa gacacagggt ggattatttc ctggcctcca caccaaacgt tcccttgcag     1620

atggagactg aatctgaggg cagcagactt ttatcagctt gagtttatgt catttgatgg     1680

acttggttca acaacaagaa cttacttaaa acaatgtact gtggtgatga gtcccagggg     1740

cactggtcag cctgtggagc cctggatgct atccacaccc acctatccct gcagctaatt     1800

tagctgatct ctaatttaac tgagctctaa tttagctgat cagattttgc ttgggtaaag     1860

ttccttttta atgttctaaa gtgtttacgg ttctcaaata tcagttaaaa actaatttta     1920

ggtggccata aacataaaat agaaaccctg taagttacag aagaccctaa attgtatcaa     1980

aaccctagag acaacttttc aatttgatcc aaatttgaac tggccaacca gtctttaaaa     2040

cactggacta gaagagataa tgattgaaac atttaaaaaa aaaaagtgct ccattcgcag     2100

gagcttttcc tgtcctgtgg ttttccagtt ggtgaccacc atgggaggtc gctggctcgg     2160

ctcactccct tctcccaccc ttgagaatgt ggagaactcc catggagagg cagaatggca     2220

ggaggtttca tgtcccgcgt tgcatctcct cctgaaagaa aagcagtgat acctgaataa     2280

tgctggctct ccgattgatc ctgtgaggat gaatttgcat ttccagaatc cttgagcatg     2340

gattagatgt ttcctgggag gtgccttgag taccattatg tgcaagctac ataattaaaa     2400

catttttctt agtttccctg ggaagctttt cttgactcac agcccaggtt cttctgccca     2460

acacaaaagg agtgagttgg ggtctttagt ctcttcttat tgggtagctc ttgctttaat     2520

attctgtttg gtgagtgtaa gggattctgc aagggacagg gggcctgact acccagtctt     2580

tgacttgtat cctctcccct cttcatacac tcctgctgaa aaatgttaat ccaaatacac     2640

atttaaactt agggtcggtc cttattctga tttgagtatt ttaatgtctc agtgtgctga     2700

tttggtagtt ggaagaatta ttcttctgga ggtctgttag actacatcct acactgactt     2760

cagaaaacag tctgtcagac aaaaaggcct tatgtcacca ctggtacctc agtttcctca     2820

tcccatttac agtttttcta actccagggt agtgtttagt gttaatattt gggatatatt     2880

ttttttcaaa actgttttta agtagtttgt aatttgtaac aaacttgtaa cctggttggg     2940

actgatattg tcatagctat gataaacttt ggatattagc agaatttggg aaaaaaaaaa     3000

aaaaaaaaaa aa                                                         3012


<210>  1110
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  1110

Met Glu Glu Arg Pro Ala Glu Thr Asn Ala Asn Val Asp Asn Ser Ala 
1               5                   10                  15      


Ser Pro Ser Val Ala Gln Leu Ala Gly Arg Phe Arg Glu Gln Ala Ala 
            20                  25                  30          


Ala Ala Lys Glu Thr Pro Ala Ser Lys Pro Thr Arg Arg Lys Pro Pro 
        35                  40                  45              


Cys Ser Leu Pro Leu Phe Pro Pro Lys Val Asp Leu Gly Gln Asn Gly 
    50                  55                  60                  


Glu Glu Lys Ser Pro Pro Asn Ala Ser His Pro Pro Lys Phe Lys Val 
65                  70                  75                  80  


Lys Ser Ser Pro Leu Ile Glu Lys Leu Gln Ala Asn Leu Thr Phe Asp 
                85                  90                  95      


Pro Ala Ala Leu Leu Pro Gly Ala Ser Pro Lys Ser Pro Gly Leu Lys 
            100                 105                 110         


Ala Met Val Ser Pro Phe His Ser Pro Pro Ser Thr Pro Ser Ser Pro 
        115                 120                 125             


Gly Val Arg Ser Arg Pro Ser Glu Ala Glu Glu Val Pro Val Ser Phe 
    130                 135                 140                 


Asp Gln Pro Pro Glu Gly Ser His Leu Pro Cys Tyr Asn Lys Val Arg 
145                 150                 155                 160 


Thr Arg Gly Ser Ile Lys Arg Arg Pro Pro Ser Arg Arg Phe Arg Arg 
                165                 170                 175     


Ser Gln Ser Asp Cys Gly Glu Leu Gly Asp Phe Arg Ala Val Glu Ser 
            180                 185                 190         


Ser Gln Gln Asn Gly Ala Lys Glu Glu Asp Gly Asp Glu Val Leu Pro 
        195                 200                 205             


Ser Lys Ser Lys Ala Pro Gly Ser Pro Leu Ser Ser Glu Gly Ala Ala 
    210                 215                 220                 


Gly Glu Gly Val Arg Thr Leu Gly Pro Ala Glu Lys Pro Pro Leu Arg 
225                 230                 235                 240 


Arg Ser Pro Ser Arg Thr Glu Lys Gln Glu Glu Asp Arg Ala Thr Glu 
                245                 250                 255     


Glu Ala Lys Asn Gly Glu Lys Ala Arg Arg Ser Ser Glu Glu Val Asp 
            260                 265                 270         


Gly Gln His Pro Ala Gln Glu Glu Val Pro Glu Ser Pro Gln Thr Ser 
        275                 280                 285             


Gly Pro Glu Ala Glu Asn Arg Cys Gly Ser Pro Arg Glu Glu Lys Pro 
    290                 295                 300                 


Ala Gly Glu Glu Ala Glu Met Glu Lys Ala Thr Glu Val Lys Gly Glu 
305                 310                 315                 320 


Arg Val Gln Asn Glu Glu Val Gly Pro Glu His Asp Ser Gln Glu Thr 
                325                 330                 335     


Lys Lys Leu Glu Glu Gly Ala Ala Val Lys Glu Thr Pro His Ser Pro 
            340                 345                 350         


Pro Gly Gly Val Lys Gly Gly Asp Val Pro Lys Gln Glu Lys Gly Lys 
        355                 360                 365             


Glu Lys Gln Gln Glu Gly Ala Val Leu Glu Pro Gly Cys Ser Pro Gln 
    370                 375                 380                 


Thr Gly Pro Ala Gln Leu Glu Thr Ser Ser Glu Val Gln Ser Glu Pro 
385                 390                 395                 400 


Ala Val Pro Lys Pro Glu Asp Asp Thr Pro Val Gln Asp Thr Lys Met 
                405                 410                 415     


<210>  1111
<211>  910
<212>  DNA
<213>  Homo Sapiens

<400>  1111
ctcctcgcct tcctccggct cagccgccgc gccgccgggc tgctccttct tcctcctcgg       60

gcgcccgcgg cgatgttcaa ccgcgccgtg agccggctga gcaggaagcg gccgccgtca      120

gacatccacg acagcgatgg cagttccagc agcagccacc agagcctcaa gagcacagcc      180

aaatgggcgg catccctgga gaatctgctg gaagacccag aaggcgtgaa aagatttagg      240

gaatttttaa aaaaggaatt cagtgaagaa aatgttttgt tttggctagc atgtgaagat      300

tttaagaaaa tgcaagataa gacgcagatg caggaaaagg caaaggagat ctacatgacc      360

tttctgtcca gcaaggcctc atcacaggtc aacgtggagg ggcagtctcg gctcaacgag      420

aagatcctgg aagaaccgca ccctctgatg ttccagaaac tccaggacca gatctttaat      480

ctcatgaagt acgacagcta cagccgcttc ttaaagtctg acttgttttt aaaacacaag      540

cgaaccgagg aagaggaaga agatttgcct gatgctcaaa ctgcagctaa aagagcttcc      600

agaatttata acacatgagc ccccaaaaag ccgggactgg cagctttaag aagcaaagga      660

atttcctctc aggaccgtgc cgggtttatc attgctttgt tatttgtaag gactgaaatg      720

tacaaaaccc ttcaatggga tgtgtgtttt attaactgct tcaccagtaa attttgcatg      780

atggctaagc taacataaaa aaagaataat aataacttgg aagttttagt ttacaaaaca      840

gagattcctt caacactgga cacgtcgagc attttgtagc ttaattaaac ctcatgtaag      900

gccaaaaaaa                                                             910


<210>  1112
<211>  181
<212>  PRT
<213>  Homo Sapiens

<400>  1112

Met Phe Asn Arg Ala Val Ser Arg Leu Ser Arg Lys Arg Pro Pro Ser 
1               5                   10                  15      


Asp Ile His Asp Ser Asp Gly Ser Ser Ser Ser Ser His Gln Ser Leu 
            20                  25                  30          


Lys Ser Thr Ala Lys Trp Ala Ala Ser Leu Glu Asn Leu Leu Glu Asp 
        35                  40                  45              


Pro Glu Gly Val Lys Arg Phe Arg Glu Phe Leu Lys Lys Glu Phe Ser 
    50                  55                  60                  


Glu Glu Asn Val Leu Phe Trp Leu Ala Cys Glu Asp Phe Lys Lys Met 
65                  70                  75                  80  


Gln Asp Lys Thr Gln Met Gln Glu Lys Ala Lys Glu Ile Tyr Met Thr 
                85                  90                  95      


Phe Leu Ser Ser Lys Ala Ser Ser Gln Val Asn Val Glu Gly Gln Ser 
            100                 105                 110         


Arg Leu Asn Glu Lys Ile Leu Glu Glu Pro His Pro Leu Met Phe Gln 
        115                 120                 125             


Lys Leu Gln Asp Gln Ile Phe Asn Leu Met Lys Tyr Asp Ser Tyr Ser 
    130                 135                 140                 


Arg Phe Leu Lys Ser Asp Leu Phe Leu Lys His Lys Arg Thr Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Leu Pro Asp Ala Gln Thr Ala Ala Lys Arg Ala Ser 
                165                 170                 175     


Arg Ile Tyr Asn Thr 
            180     


<210>  1113
<211>  2540
<212>  DNA
<213>  Homo Sapiens

<400>  1113
gattggctgg cgcggattcc agctgctttc caagtcagcg gcgcctagtg agagtcaggg       60

gggcccggcc cgcgccctcc ccgcccagcc gcctccccgt cgacgcccag ggctggggcg      120

agccaggctg cctttcgaac ttggggggct tctcctcttg tctcccactg gtgctctggc      180

tgtgaatcca tccaggggcc aggatgacaa tccgacacca aggccagcag tacaggccga      240

ggatggcatt tctccaaaag attgaagcgc tcgtgaagga catgcagaac ccagagacag      300

gggtccgaat gcagaaccag agggtcctgg tcaccagcgt tcctcatgcc atgacaggaa      360

gtgatgttct gcaatggatc gtccagcggc tttggatctc cagtctggag gcacagaact      420

tgggcaactt tattgtcagg tatggctaca tttaccccct gcaagacccc aagaatctca      480

ttctcaagcc tgatggcagc ctctacagat ttcagacacc gtatttctgg cccacccagc      540

agtggccagc tgaagatacc gattacgcca tctatctggc caagcgaaat atcaaaaaga      600

aagggatttt ggaagaatat gaaaaggaaa attacaattt cttgaaccaa aaaatgaact      660

ataagtggga ctttgtcatt atgcaggcca aagagcagta cagggctgga aaggagagga      720

acaaagcaga cagatatgcc ctggactgcc aggagaaggc atactggctg gtgcaccgat      780

gccctcctgg aatggacaat gtgctggact acggcctgga ccgagtgacc aatccgaatg      840

aagtcaaggt aaaccagaaa caaacagtcg ttgctgtcaa aaaagagatc atgtattacc      900

aacaggcctt gatgaggtcc acagtgaagt cttctgtgtc cctgggaggg attgtgaaat      960

acagtgagca gttctcatcc aacgatgcca tcatgtcagg ctgcctcccc agcaacccct     1020

ggatcaccga tgacacccag ttctgggact taaatgccaa attggtggaa atcccaacca     1080

agatgcgagt ggaacgatgg gccttcaact tcagcgaatt gatccgagac cccaaaggtc     1140

gacagagctt ccagtacttc ctcaagaaag aattcagtgg agagaatctg ggattctggg     1200

aagcctgcga ggatctgaag tatggagatc agtccaaagt caaggagaaa gcagaggaga     1260

tttacaagct gttcctggcc ccgggggcga ggcgctggat caacatagat ggcaaaacca     1320

tggacatcac agtgaagggg ctgaagcacc cccaccgcta tgtgctggac gccgcacaaa     1380

cccacattta catgctcatg aagaaggatt cttatgctcg ctatttaaaa tctccgatct     1440

ataaggacat gctggccaaa gctattgaac ctcaggaaac caccaagaaa agctccaccc     1500

tcccttttat gcggcgtcac ctgcgctcca gcccaagccc tgtcatcctg agacagctgg     1560

aagaggaagc caaggcccga gaagcagcca acactgtgga catcacccag ccgggccagc     1620

acatggctcc cagcccccat ctgaccgtgt acaccgggac ctgcatgccc ccgtctcctt     1680

ctagcccctt ctcctcctcc tgccgctccc ccaggaagcc tttcgcctca cccagccgct     1740

tcatccggcg acccagcacc accatctgcc cctcacccat cagagtggcc ttggagagct     1800

catcgggctt ggagcagaaa ggggagtgca gcgggtccat ggccccccgt gggccctctg     1860

tcaccgagag cagcgaggcc tccctcgaca cctcctggcc tcgcagccgg cccagggccc     1920

ctcctaaggc ccgcatggct ctgtccttca gcaggtttct gagacgaggc tgtctggcct     1980

cacctgtctt tgccaggctc tcacccaagt gccctgctgt gtcccacggg agggtgcagc     2040

ccctggggga cgtgggccag cagctgccac gattgaaatc caagagagta gcaaactttt     2100

tccagatcaa aatggatgtg cccacgggga gcgggacctg cttgatggac tcggaggatg     2160

ctggaacagg agagtcgggt gaccgggcca cagaaaagga ggtcatctgc ccctgggaga     2220

gcctgtaagg aaagaggcag gctgagctgg gggctctgga ccaggaagat gctctgacag     2280

atgccatggt atgggccaca ggacacactt gctcgagaac caaagtgcat ttgggtgaca     2340

tttgaagatt ggggagacaa gatggggtag attgtggcaa agaatgctct ggctggttac     2400

caggggccaa ctccttctcc tcttcctgac cctccctccc ctgggcagaa gaaacgcatg     2460

tggaccagaa gactttccct gctgccttaa aaccaataaa aggttaactt taagtttctt     2520

ggaaaaaaaa aaaaaaaaaa                                                 2540


<210>  1114
<211>  674
<212>  PRT
<213>  Homo Sapiens

<400>  1114

Met Thr Ile Arg His Gln Gly Gln Gln Tyr Arg Pro Arg Met Ala Phe 
1               5                   10                  15      


Leu Gln Lys Ile Glu Ala Leu Val Lys Asp Met Gln Asn Pro Glu Thr 
            20                  25                  30          


Gly Val Arg Met Gln Asn Gln Arg Val Leu Val Thr Ser Val Pro His 
        35                  40                  45              


Ala Met Thr Gly Ser Asp Val Leu Gln Trp Ile Val Gln Arg Leu Trp 
    50                  55                  60                  


Ile Ser Ser Leu Glu Ala Gln Asn Leu Gly Asn Phe Ile Val Arg Tyr 
65                  70                  75                  80  


Gly Tyr Ile Tyr Pro Leu Gln Asp Pro Lys Asn Leu Ile Leu Lys Pro 
                85                  90                  95      


Asp Gly Ser Leu Tyr Arg Phe Gln Thr Pro Tyr Phe Trp Pro Thr Gln 
            100                 105                 110         


Gln Trp Pro Ala Glu Asp Thr Asp Tyr Ala Ile Tyr Leu Ala Lys Arg 
        115                 120                 125             


Asn Ile Lys Lys Lys Gly Ile Leu Glu Glu Tyr Glu Lys Glu Asn Tyr 
    130                 135                 140                 


Asn Phe Leu Asn Gln Lys Met Asn Tyr Lys Trp Asp Phe Val Ile Met 
145                 150                 155                 160 


Gln Ala Lys Glu Gln Tyr Arg Ala Gly Lys Glu Arg Asn Lys Ala Asp 
                165                 170                 175     


Arg Tyr Ala Leu Asp Cys Gln Glu Lys Ala Tyr Trp Leu Val His Arg 
            180                 185                 190         


Cys Pro Pro Gly Met Asp Asn Val Leu Asp Tyr Gly Leu Asp Arg Val 
        195                 200                 205             


Thr Asn Pro Asn Glu Val Lys Val Asn Gln Lys Gln Thr Val Val Ala 
    210                 215                 220                 


Val Lys Lys Glu Ile Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr 
225                 230                 235                 240 


Val Lys Ser Ser Val Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln 
                245                 250                 255     


Phe Ser Ser Asn Asp Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro 
            260                 265                 270         


Trp Ile Thr Asp Asp Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val 
        275                 280                 285             


Glu Ile Pro Thr Lys Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser 
    290                 295                 300                 


Glu Leu Ile Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu 
305                 310                 315                 320 


Lys Lys Glu Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu 
                325                 330                 335     


Asp Leu Lys Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu 
            340                 345                 350         


Ile Tyr Lys Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile 
        355                 360                 365             


Asp Gly Lys Thr Met Asp Ile Thr Val Lys Gly Leu Lys His Pro His 
    370                 375                 380                 


Arg Tyr Val Leu Asp Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys 
385                 390                 395                 400 


Lys Asp Ser Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met 
                405                 410                 415     


Leu Ala Lys Ala Ile Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr 
            420                 425                 430         


Leu Pro Phe Met Arg Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile 
        435                 440                 445             


Leu Arg Gln Leu Glu Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr 
    450                 455                 460                 


Val Asp Ile Thr Gln Pro Gly Gln His Met Ala Pro Ser Pro His Leu 
465                 470                 475                 480 


Thr Val Tyr Thr Gly Thr Cys Met Pro Pro Ser Pro Ser Ser Pro Phe 
                485                 490                 495     


Ser Ser Ser Cys Arg Ser Pro Arg Lys Pro Phe Ala Ser Pro Ser Arg 
            500                 505                 510         


Phe Ile Arg Arg Pro Ser Thr Thr Ile Cys Pro Ser Pro Ile Arg Val 
        515                 520                 525             


Ala Leu Glu Ser Ser Ser Gly Leu Glu Gln Lys Gly Glu Cys Ser Gly 
    530                 535                 540                 


Ser Met Ala Pro Arg Gly Pro Ser Val Thr Glu Ser Ser Glu Ala Ser 
545                 550                 555                 560 


Leu Asp Thr Ser Trp Pro Arg Ser Arg Pro Arg Ala Pro Pro Lys Ala 
                565                 570                 575     


Arg Met Ala Leu Ser Phe Ser Arg Phe Leu Arg Arg Gly Cys Leu Ala 
            580                 585                 590         


Ser Pro Val Phe Ala Arg Leu Ser Pro Lys Cys Pro Ala Val Ser His 
        595                 600                 605             


Gly Arg Val Gln Pro Leu Gly Asp Val Gly Gln Gln Leu Pro Arg Leu 
    610                 615                 620                 


Lys Ser Lys Arg Val Ala Asn Phe Phe Gln Ile Lys Met Asp Val Pro 
625                 630                 635                 640 


Thr Gly Ser Gly Thr Cys Leu Met Asp Ser Glu Asp Ala Gly Thr Gly 
                645                 650                 655     


Glu Ser Gly Asp Arg Ala Thr Glu Lys Glu Val Ile Cys Pro Trp Glu 
            660                 665                 670         


Ser Leu 
        


<210>  1115
<211>  4587
<212>  DNA
<213>  Homo Sapiens

<400>  1115
gttccgcctg gctgccccgc ctgggagcgg ggtgggggca ggcgaagggg agggctgcgg       60

gtggaaaggg gcgagcccct ctcgcccggg actgggaaga gcggccacgg cgccgggcga      120

ggcggcaggg cgaggcagtg ccatgctgcc tttgtgcaaa gttgggcggc gggcggcgcg      180

ccgcgcgcag gggccccgca cacccgcgac cgcgcgcagc cgtggctgct gctgagtggc      240

gggggccccc ccgctccccc cggcccttga aggcggagag agctcgcgtc tcgctcggct      300

tcagggtaag tccagctgtg agcagagtgt tctgttcttc acttccagca agccagaact      360

cttctatcca taggccaacc tatgttgcag ttgattaagg ggtgcagctc ccatataaat      420

gctggcagag tttcataaat ggacgctgac atggactacg aaagacccaa cgttgaaact      480

atcaaatgtg tggtcgtggg tgacaatgcc gtggggaaga cgcgcttgat ctgtgccagg      540

gcgtgcaaca ccacactcac gcagtatcag ctgctggcca cccacgtgcc aacagtgtgg      600

gcgattgacc agtaccgcgt gtgccaggag gtcttggagc gttctcggga tgttgttgat      660

gaagtgagtg tttctctcag gctttgggat acttttggtg atcatcacaa agacagacgc      720

tttgcatatg gcaggtctga tgttgtggtc ctctgttttt cgattgctaa tcccaattcc      780

ctaaatcatg tgaaaagcat gtggtatcca gaaatcaagc acttttgccc tcgaacaccc      840

gttatccttg ttgggtgcca gcttgatctc cgctatgccg acctggaagc tgttaatcga      900

gccaggcgcc cgttagcaag gcccataaag agaggggata ttttgccccc agaaaaaggc      960

cgagaggtag caaaggaact tggcttacca tactatgaaa caagcgtgtt tgaccagttt     1020

ggtatcaagg atgtgtttga caatgcaatc cgagcagcgc tgatttcccg caggcacctg     1080

caattctgga aatcccacct aaagaaagtc cagaaacctt tacttcaggc acccttccta     1140

cctccaaaag cccctccacc ggtcatcaaa attccagagt gtccttccat ggggacaaat     1200

gaagctgcct gtttactgga caatcctcta tgtgccgatg ttctgttcat ccttcaggac     1260

caggaacaca tctttgcaca tcgaatttac ctcgctacct cttcttccaa attttatgat     1320

ctgtttttaa tggaatgtga agaatcccca aatgggagtg aaggagcctg tgagaaagag     1380

aagcagagca gagatttcca ggggcggata ttgagtgtcg acccagagga agaaagggag     1440

gagggcccgc ctaggattcc tcaggccgac cagtggaagt cttcaaacaa gagcctggtg     1500

gaggctctgg ggctggaagc cgagggtgca gttcctgaga cacagacttt gaccggatgg     1560

agtaaggggt tcattggcat gcacagggaa atgcaagtca accccatttc aaagcggatg     1620

gggcccatga ctgtggtcag gatggacgct tcagtccagc caggcccttt tcggaccctg     1680

ctccagtttc tttatacggg acaactggat gaaaaggaaa aggatttggt gggcctggct     1740

cagatcgcag aggtcctcga gatgttcgat ttgaggatga tggtggaaaa catcatgaac     1800

aaggaagcct tcatgaacca ggagattacg aaagcctttc acgtaaggaa agccaatcgg     1860

ataaaagagt gtctcagcaa gggaacgttc tcggacgtga catttaaatt ggacgatgga     1920

gccatcagtg cccacaagcc gctgctgatc tgtagctgtg agtggatggc agccatgttc     1980

ggggggtcat ttgtggaaag tgccaacagt gaggtgtatc tcccgaacat aaacaagata     2040

tcaatgcaag cagtattgga ttatctctat accaagcagt tgtctcctaa cttggatctg     2100

gacccgctgg aattaattgc cttggcaaac agattttgcc tgccacactt ggttgcactt     2160

gcagaacagc atgccgttca ggagttgacc aaagccgcca cgagtggcgt gggcattgac     2220

ggagaagtgc tctcttactt ggaattggct cagtttcaca atgcccacca gttggccgcc     2280

tggtgtttgc accacatctg caccaactac aacagtgtat gctccaagtt ccgtaaggaa     2340

atcaaatcaa aatctgcaga caaccaggaa tacttcgagc ggcaccgctg gccccctgtg     2400

tggtacctga aggaagaaga tcactaccag cgtgtgaaaa gggaacgaga gaaggaagat     2460

attgcactaa ataagcatcg ctcaagacga aagtggtgct tctggaattc atctccagca     2520

gtggcctgaa gaggaagaga aaaaaaacaa aaaacagaaa ccaatcggta atctgatcca     2580

ccacttttca aagcactact ataaaattcg tcttgttaga gatacgacat agttcaggtt     2640

tcgggcactg atcttcctcc acttttgtgc atttatcttt gttaggatca aagcacaagc     2700

tcaccatcaa tgagcctgga caaaaaggga agctgactct cactgcattc cttaaactga     2760

tatgtatatt ttttttgtta ggaggcttaa taaactttag tctgttattt tgtttctttt     2820

tatacaaaga aaaaaaattc agctttcatg tttctgattc cagattggaa aatattttta     2880

tatggtctgt tgtattttgt tgaaatgaaa atactgtgta ttactttatt ttacaggcca     2940

caattgatta tgaagtcacc ctgtgattct ctttgcccac atgaccaccg agcattatta     3000

cgtaattaga gggttatcct tttgttgtga aaggaaggag gggactgaaa tctcccaaag     3060

tgcaaattgg agagtgttta atctttgttc tgttgaataa catcggtgta attacaaagt     3120

caactccaag aatgtgtatt tacaatattt gccatgttaa gtgctggtaa ttatatggtt     3180

atatgtgcca tgtaaaatat agtgatatca aatattctgt tgtttccaat gtctagtttc     3240

aagaggacaa tctttataat cattagaagg gcttattaaa tcccagcatt atccagggca     3300

aactcactgg tggacctgaa tacataagat accattagtg cgctggtgtt cggattgctg     3360

tattagggtt tacatctctc agtattcctt gaacttgcca tgcttctgca tgcagattct     3420

tcactgactt gaattgagat gggcaaggga aaaggtccct ggactccctc ctgccatcta     3480

caggcttgtc acatctcacc accagaaaca ggcttcctca ggcttctcac ctgtggccaa     3540

cttcactttg taagacccat atttttaact cttcccaggg aaaattcatg ttgctgcaga     3600

agtaggctaa ggcagaccac ccacttctgc tgaaatgcat tgggagcctg tgaaagcaca     3660

aagctggagg ctgggcgcct gcgttctcct acacggaaag gaatctaatt ccaagagtct     3720

aggaaatggt gctattgtga gttcgttctg actctttctc attctgagtt ttcagtgtta     3780

aactaggaag tgtgacagca ggggagcttt cgtgaggcag tcagtcattg cttctctgta     3840

aattaaaatg ttacagcaca cacatacaca cacagagagc atttcaaggc cacagctcca     3900

cacctgccat gggatgttaa tgtggcaggg ggtggggctc attctgttgg gaggtcaaat     3960

taccaatgcc aaggactgtt gattttgttt ttatttttat tttttcttct agcttttcag     4020

aagatggaaa tgagacagtt gagtccaaac cccaatgctg acagccatat gcatttgaaa     4080

atctatctag attacagatg ggcatttatt actggcagtg gaaacaccag atagaagatc     4140

ttaggagagg cccagaaatg catcaccttg tcatgacaaa agagaaggca gtagagtagg     4200

gatagttaca aatgcatcca tcttaattat tttcaatagg cttgtaaatc ttatcgatgg     4260

aaggagaaag gagacaagat gtggaagaat tgacatgtat cccaccataa aatggtagaa     4320

gatgagtttt caatgagtag tcatagttga aattttacaa ccaaagctcc catttgattg     4380

taatcttgcc aaaatataat ggatgtataa atgaacttgg ggtataagca ataatatcca     4440

ctagtgttgt tatcagctac tgtaaccaag tggctggttc atttggttga tgctgattat     4500

ggcctttaac catggtggtt tgttgtgtgt tttttatttc acaaaaagcc aataaaattg     4560

tttagctata aaaaaaaaaa aaaaaaa                                         4587


<210>  1116
<211>  696
<212>  PRT
<213>  Homo Sapiens

<400>  1116

Met Asp Ala Asp Met Asp Tyr Glu Arg Pro Asn Val Glu Thr Ile Lys 
1               5                   10                  15      


Cys Val Val Val Gly Asp Asn Ala Val Gly Lys Thr Arg Leu Ile Cys 
            20                  25                  30          


Ala Arg Ala Cys Asn Thr Thr Leu Thr Gln Tyr Gln Leu Leu Ala Thr 
        35                  40                  45              


His Val Pro Thr Val Trp Ala Ile Asp Gln Tyr Arg Val Cys Gln Glu 
    50                  55                  60                  


Val Leu Glu Arg Ser Arg Asp Val Val Asp Glu Val Ser Val Ser Leu 
65                  70                  75                  80  


Arg Leu Trp Asp Thr Phe Gly Asp His His Lys Asp Arg Arg Phe Ala 
                85                  90                  95      


Tyr Gly Arg Ser Asp Val Val Val Leu Cys Phe Ser Ile Ala Asn Pro 
            100                 105                 110         


Asn Ser Leu Asn His Val Lys Ser Met Trp Tyr Pro Glu Ile Lys His 
        115                 120                 125             


Phe Cys Pro Arg Thr Pro Val Ile Leu Val Gly Cys Gln Leu Asp Leu 
    130                 135                 140                 


Arg Tyr Ala Asp Leu Glu Ala Val Asn Arg Ala Arg Arg Pro Leu Ala 
145                 150                 155                 160 


Arg Pro Ile Lys Arg Gly Asp Ile Leu Pro Pro Glu Lys Gly Arg Glu 
                165                 170                 175     


Val Ala Lys Glu Leu Gly Leu Pro Tyr Tyr Glu Thr Ser Val Phe Asp 
            180                 185                 190         


Gln Phe Gly Ile Lys Asp Val Phe Asp Asn Ala Ile Arg Ala Ala Leu 
        195                 200                 205             


Ile Ser Arg Arg His Leu Gln Phe Trp Lys Ser His Leu Lys Lys Val 
    210                 215                 220                 


Gln Lys Pro Leu Leu Gln Ala Pro Phe Leu Pro Pro Lys Ala Pro Pro 
225                 230                 235                 240 


Pro Val Ile Lys Ile Pro Glu Cys Pro Ser Met Gly Thr Asn Glu Ala 
                245                 250                 255     


Ala Cys Leu Leu Asp Asn Pro Leu Cys Ala Asp Val Leu Phe Ile Leu 
            260                 265                 270         


Gln Asp Gln Glu His Ile Phe Ala His Arg Ile Tyr Leu Ala Thr Ser 
        275                 280                 285             


Ser Ser Lys Phe Tyr Asp Leu Phe Leu Met Glu Cys Glu Glu Ser Pro 
    290                 295                 300                 


Asn Gly Ser Glu Gly Ala Cys Glu Lys Glu Lys Gln Ser Arg Asp Phe 
305                 310                 315                 320 


Gln Gly Arg Ile Leu Ser Val Asp Pro Glu Glu Glu Arg Glu Glu Gly 
                325                 330                 335     


Pro Pro Arg Ile Pro Gln Ala Asp Gln Trp Lys Ser Ser Asn Lys Ser 
            340                 345                 350         


Leu Val Glu Ala Leu Gly Leu Glu Ala Glu Gly Ala Val Pro Glu Thr 
        355                 360                 365             


Gln Thr Leu Thr Gly Trp Ser Lys Gly Phe Ile Gly Met His Arg Glu 
    370                 375                 380                 


Met Gln Val Asn Pro Ile Ser Lys Arg Met Gly Pro Met Thr Val Val 
385                 390                 395                 400 


Arg Met Asp Ala Ser Val Gln Pro Gly Pro Phe Arg Thr Leu Leu Gln 
                405                 410                 415     


Phe Leu Tyr Thr Gly Gln Leu Asp Glu Lys Glu Lys Asp Leu Val Gly 
            420                 425                 430         


Leu Ala Gln Ile Ala Glu Val Leu Glu Met Phe Asp Leu Arg Met Met 
        435                 440                 445             


Val Glu Asn Ile Met Asn Lys Glu Ala Phe Met Asn Gln Glu Ile Thr 
    450                 455                 460                 


Lys Ala Phe His Val Arg Lys Ala Asn Arg Ile Lys Glu Cys Leu Ser 
465                 470                 475                 480 


Lys Gly Thr Phe Ser Asp Val Thr Phe Lys Leu Asp Asp Gly Ala Ile 
                485                 490                 495     


Ser Ala His Lys Pro Leu Leu Ile Cys Ser Cys Glu Trp Met Ala Ala 
            500                 505                 510         


Met Phe Gly Gly Ser Phe Val Glu Ser Ala Asn Ser Glu Val Tyr Leu 
        515                 520                 525             


Pro Asn Ile Asn Lys Ile Ser Met Gln Ala Val Leu Asp Tyr Leu Tyr 
    530                 535                 540                 


Thr Lys Gln Leu Ser Pro Asn Leu Asp Leu Asp Pro Leu Glu Leu Ile 
545                 550                 555                 560 


Ala Leu Ala Asn Arg Phe Cys Leu Pro His Leu Val Ala Leu Ala Glu 
                565                 570                 575     


Gln His Ala Val Gln Glu Leu Thr Lys Ala Ala Thr Ser Gly Val Gly 
            580                 585                 590         


Ile Asp Gly Glu Val Leu Ser Tyr Leu Glu Leu Ala Gln Phe His Asn 
        595                 600                 605             


Ala His Gln Leu Ala Ala Trp Cys Leu His His Ile Cys Thr Asn Tyr 
    610                 615                 620                 


Asn Ser Val Cys Ser Lys Phe Arg Lys Glu Ile Lys Ser Lys Ser Ala 
625                 630                 635                 640 


Asp Asn Gln Glu Tyr Phe Glu Arg His Arg Trp Pro Pro Val Trp Tyr 
                645                 650                 655     


Leu Lys Glu Glu Asp His Tyr Gln Arg Val Lys Arg Glu Arg Glu Lys 
            660                 665                 670         


Glu Asp Ile Ala Leu Asn Lys His Arg Ser Arg Arg Lys Trp Cys Phe 
        675                 680                 685             


Trp Asn Ser Ser Pro Ala Val Ala 
    690                 695     


<210>  1117
<211>  716
<212>  DNA
<213>  Homo Sapiens

<400>  1117
gaacaaccag ctggatcagt tctcacagga gccacagctc agagactggg aaacatggtt       60

ccaaaactgt tcacttccca aatttgtctg cttcttctgt tggggcttat gggtgtggag      120

ggctcactcc atgccagacc cccacagttt acgagggctc agtggtttgc catccagcac      180

atcagtctga acccccctcg atgcaccatt gcaatgcggg caattaacaa ttatcgatgg      240

cgttgcaaaa accaaaatac ttttcttcgt acaacttttg ctaatgtagt taatgtttgt      300

ggtaaccaaa gtatacgctg ccctcataac agaactctca acaattgtca tcggagtaga      360

ttccgggtgc ctttactcca ctgtgacctc ataaatccag gtgcacagaa tatttcaaac      420

tgcacgtatg cagacagacc aggaaggagg ttctatgtag ttgcatgtga caacagagat      480

ccacgggatt ctccacggta tcctgtggtt ccagttcacc tggataccac catctaagct      540

cctgtatcag cagtcctcat catcactcat ctgccaagct cctcaatcat agccaagatc      600

ccatccctcc atgtactctg ggtatcagca actgtcctca tcagtctcca taccccttca      660

gctttcctga gctgaagtcc cttgtgaacc ctgcaataaa ctgctttgca aattca          716


<210>  1118
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  1118

Met Val Pro Lys Leu Phe Thr Ser Gln Ile Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Met Gly Val Glu Gly Ser Leu His Ala Arg Pro Pro Gln Phe 
            20                  25                  30          


Thr Arg Ala Gln Trp Phe Ala Ile Gln His Ile Ser Leu Asn Pro Pro 
        35                  40                  45              


Arg Cys Thr Ile Ala Met Arg Ala Ile Asn Asn Tyr Arg Trp Arg Cys 
    50                  55                  60                  


Lys Asn Gln Asn Thr Phe Leu Arg Thr Thr Phe Ala Asn Val Val Asn 
65                  70                  75                  80  


Val Cys Gly Asn Gln Ser Ile Arg Cys Pro His Asn Arg Thr Leu Asn 
                85                  90                  95      


Asn Cys His Arg Ser Arg Phe Arg Val Pro Leu Leu His Cys Asp Leu 
            100                 105                 110         


Ile Asn Pro Gly Ala Gln Asn Ile Ser Asn Cys Thr Tyr Ala Asp Arg 
        115                 120                 125             


Pro Gly Arg Arg Phe Tyr Val Val Ala Cys Asp Asn Arg Asp Pro Arg 
    130                 135                 140                 


Asp Ser Pro Arg Tyr Pro Val Val Pro Val His Leu Asp Thr Thr Ile 
145                 150                 155                 160 


<210>  1119
<211>  6659
<212>  DNA
<213>  Homo Sapiens

<400>  1119
ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt       60

gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg      120

tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat      180

agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa      240

agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta      300

tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt      360

gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg      420

aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta      480

tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt      540

ggataaaaca atcacagata tatgttttga aaatgtaacc atatttaatg aagcagggcc      600

agactttcag ataaaggtgg aagtgtatag ttgctgtaca gaagaatctt ctataaccaa      660

cacaccaaaa aagctagcta agaaactcaa gacatctata agtaaagcta caggaaagaa      720

aataagttca gtgcttcaag aagaggatga tgaaatgtgc ttgctcctca gctctgctgt      780

ttttggtgta aagtataatt tgctagctca cactacccta accttggaaa gtgctgagga      840

tagtttcaag acccataatc tgtctattaa tggaaatgag gagtcttcat tttggcttcc      900

cctgtatggc aacatgtgct gccgactagt tgcccagcca gcttgtatgg ctgaggatgc      960

atttgcagga tttcttaatc agcagcaaat ggtagaaggt ctgattagtt ggagaaggtt     1020

gtattgtgtt ttgcgaggag gtaaactcta ttgtttttac agtccagagg aaattgaagc     1080

taaagtggaa ccagctttgg tagtacccat taacaaggaa accagaatcc gggcaatgga     1140

taaggatgcc aagaaaagaa tccataattt ctctgtcatc aatcctgttc ctggacaagc     1200

tataactcag atttttgcag ttgacaatag agaagatctt cagaagtgga tggaagcctt     1260

ctggcagcat ttctttgatc ttagccaatg gaagcactgt tgtgaagaac ttatgaaaat     1320

tgagattatg tcaccacgga aaccaccttt gttcttgaca aaagaggcaa cctcagtcta     1380

ccatgatatg agcattgatt cacctatgaa acttgaaagt ttaacggata taatacaaaa     1440

aaaaattgaa gagacaaatg ggcagttcct tattggtcag catgaagaat ccttaccacc     1500

tccttgggcc acactctttg atggtaacca tcaaatggtc atccagaaaa aggtactgta     1560

tcctgcaagt gagccattac atgatgaaaa agggaaaaag agacaagctc cccttcctcc     1620

ttctgataaa cttccattca gcttaaaatc acagagtaac acagatcaat tggttaagga     1680

caactgggga aaaacaagtg tatctcagac atcgtctttg gataccaaac tatcaactct     1740

aatgcatcac ttacagaaac caatggctgc tcctcgaaaa cttctgcctg ccaggagaaa     1800

tagattaagt gatggtgagc acacagacac taaaaccaat tttgaagcca agccagtgcc     1860

agctccaagg cagaaatcca tcaaagacat tctggaccct agatcatggc tgcaggcaca     1920

agtatagaaa actcttaatg ataaaacatt taacaaaatc tataactgtg aagcttaatt     1980

cagaggcatt atagaataat gtgtaattat ataggtaaat atagtgattt ataccaataa     2040

ttaataagct attaggtata gaaaaacatt ttataatgaa gaagtggatt tctcttttac     2100

tcctgatttg cagaatgtaa gtgatttctc cagcagtgtg caagaggcag tttctagaca     2160

atatcctaat tgttggaagg gttaatttat tcctgaatta gtaccaggca gtgaataagc     2220

cctaggcaga ataaagcatt aaaatttctt ttggggagag actgtctagt aatttaaaat     2280

gtgttaaata tgaaccatat tctcattgtg agaattttaa tactaatgga atgtttcaaa     2340

ggttttattc aaaccacaaa ttatagaatc cacccaagaa aattttctta gcattctgga     2400

attctcatct aatggttcac tggctctcat ctattgttta actcactagt ttataggcct     2460

gaccttttaa attcctggga taaattttag aatattaaat tcttcatctt taaagggaat     2520

ttgtaatgtg ctattcaaac ttgtttcctt gatgagccct gaaatactgt tgacattaac     2580

tttcataaat gaagcataac acttactagt ttagagaaat ggtagatgaa atgctcttta     2640

cattcaattt tctgtgtgtg gtgctaattt ccattgtgac tttggaattt agggaagtga     2700

gtagctgatc aacaccttaa aattcattta atacttattt aaaaagaaga tgagagattc     2760

aaaaatatca gaaaagttgg ccatggtaaa taattttcag aattcttttt taaaatttta     2820

attagatttc cttttcctag taagagttga tgtctgctag tggtattttt cattaaatgt     2880

catattctta caacagtgac attggaatca tttccatagg aggtaatttc catagcaact     2940

aatcatagtg acccaaacag gattataaag tcaagtgagg aataaatagc agaaaaatac     3000

cttaaaggaa caaaaaatcc attttttata ataatgcttt ttgtaaacaa gagcagaaca     3060

gttttaaaaa tctaattaga atttccaaat aaaacagttt ccataaggtg tcagcaacag     3120

cactaaaaat ctcaaatcac actgaaccct aaatgtcatt gcaagaaata aaaatttaag     3180

aattaaattg ctgccctgtg tataatctct tgagatcttt ttaaagctag caagaactct     3240

atttggatca gaactacatt attacaaaac aaaatgaaca cttgaccaaa aaaccacatt     3300

aatttaaatg gagcctttca ttattttcag atagcggggt cttttccatt tatagagaat     3360

gatgtaactg ccaggacact tttgtgtttg cccaggactc ctagtaagaa ttgaatcttg     3420

agggagtaat gataacaaaa ggtttcttgt gactggtaac atcaggacag acagagtttt     3480

tggtgagaag aaagtactat atgcctgctt gatagcatgt agagatcatc acatgtatgg     3540

aaaccttaaa aagtaaactt attttttcta actagaaggc tctcataagt ttctgttatg     3600

attgccattt caataaatga cattaaaaat ctaaaggata ttattgtttg aatttttggg     3660

ttatttttta aaacttcatt gctgtttttg acagcatttg tgactgtcat tgccactaaa     3720

ttattgagct agaagatgct gcagggaaaa ttgttttgaa gctggcatct aagcattctt     3780

ttttttttcc tagttgatgc cttcctttat tacaaatcag tattaaaact tccagattat     3840

attcttgtca tttttcctca tgcagataac agcaggaagg acttaaggtg tataagaaaa     3900

agaaagtatt catacagaaa ttacctagca gttgtgccct cagagtagaa ctttgaaaca     3960

ggactgaagc cctttttacc tagaaccatt taaaagcctg agcaaggacc accaccccct     4020

ccccaccaaa ttattcggtc tctttctggg gggcccagct tactgtatgt tacaagtctt     4080

tgaaatgggt ctggtgtctt cagctcctga aatgctaatt taccccttac ctaaggagtg     4140

tagttataat acagagttgg tttccttcct tccttccttc cttccttcct tccttccttc     4200

cttccttcct tccttccttc cttccttcat tccctctgtc cgtctctcct tccctccttc     4260

cctccttcct tcctttttgt ctttgtttct ttctctggcc ccctgtcctc tctctctgtc     4320

tcatcccctt ttcccacttt ccttctgtct ctccttcctc ccttccttta cagtttaaaa     4380

aaaaaatcta aaaatagtta agcactgtgt caaagagtgt ttcaaaagaa ttgtttgttt     4440

tctcatttct taaaccagaa gtttatgaca aataaatatg ccatgtaata tgaaagctgc     4500

ttcagctttt tatgagcttt cacattcctt gtttgtcctt ttaatttgtt tcttgatata     4560

tgaagactat aaacttgaaa caaagagtta gctgtcagct cttgataata taattgggga     4620

aacagaatag atattttatg atatgataat tctgatgatc taaagataat gtcttagaca     4680

attaccttta catttcaagc tctgggatat aaattacgta gtcagcatta agatagtatt     4740

atttttaatt gctactaagt ggtaactttt gtattttaat atcttgcaag ggcaaagaag     4800

gcatttttaa aattctaaat gcacacctcc taaggtaaat agtctttcaa aaatatcagg     4860

cgtgccaact cttgctgagt tttgttaaat cctccttaac tgtctgcagt gccccctgac     4920

ttcttttaaa tggatgtgaa tatatgtgga aaactaaatc catttattat aaatgcctta     4980

tctttaccct ttgggatctt actaaatgca ttttacctgc tactatttat taaaaatgga     5040

agctgtcttg aattagagat acctcacgta aggtaggtta agcagtcaag tatttcttta     5100

ggcttatgtt cagcacctca gccccctact gagaagttaa ttaattcagt ccaaaatgaa     5160

attatagggc agtttggtgc aatttatgtt aaatgccatt tgaatgtaat cacctgtgtt     5220

accacgaatg aggcacaact atactacatg gacagagtac tgcattgcac catgagcaag     5280

aactgctctg caagaaaaat atctgtccct gtggtctgaa tttatcaaaa ctcattttct     5340

tgttaaagag tgaattattg aatagtaatt aaactttaac tgatgaccat ttatattcta     5400

gtagccatct tcactgttag tcttaaatta taatgtaaag ttgacatttt ccccttacat     5460

ttcaaaggca tcactatttt taaatgttta catatgttta catgtttgtg tgcaactgct     5520

tcattgctat taatagttaa atgaaatctg catattctgg atcatagatg ttcttagtta     5580

actctgggaa agatgttacc tttgggtttt taaaagacaa gtcatcattt gaaaatatat     5640

tagggtgtgt tgattttctg acatgcttgt gtaattggct ttgtttataa tttttatttt     5700

ttaatatggg tcagactttt ggattaaaaa gtattatatc atggacatac attttttaaa     5760

gtaccaaagg tatttggtaa gcgagcccaa gtcatgtaat tgaaacttct gtacattaaa     5820

agaactgatt catgaagacg ttttctaact ttttctcttt aagtgctcct ctagactaga     5880

ctgattgaag tagacagtgt ggtggaatca gtttaatcag aaaaagacat accaagtagc     5940

tggtgctaat tattataaga ctaacattct gataagccat ggtataatta acattattaa     6000

aatgtttaca tataatcctt cttaaagtat actcttttaa aaatccattg acataacctt     6060

acttttagtt tagtgatcca gaatttcccc agagcttaag ccactgcagt aaattaggta     6120

cgtaggatat tcagtcgcta ctagccacaa ggagtctcct tattttaatg tacctccctc     6180

agtactttat tcctgcagag cgcctcagag tgggggagag aaatgagcaa tcctggctca     6240

gttggattat ttcagcattt tatttctaaa tctgtagtgt gatcagaaat atttaaaatt     6300

aaaaaaatac tttacagaga gaggcctact aatcaatgtg cttagagaaa caaactacct     6360

ttacattcaa ttaacaacaa aaaaagttac agaaatttta acaaacattt ttctttatct     6420

gagtatggga gaaaatacta atgctgacac gtttaataat tagaaaagat cattccagat     6480

cttatggaaa attgtgtttt aaattccagc agtttgctct tgagacatgg taatctctta     6540

atgtaactac taaaggagag gtagattgaa aagatcttgt atatacataa ttatgtcaga     6600

tggttcaaga tatcaaaata aattgttttg ttgaaaatga aaaaaaaaaa aaaaaaaaa      6659


<210>  1120
<211>  609
<212>  PRT
<213>  Homo Sapiens

<400>  1120

Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg Thr 
                85                  90                  95      


Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu Met 
            100                 105                 110         


Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr 
        115                 120                 125             


Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr Asp 
    130                 135                 140                 


Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
145                 150                 155                 160 


Thr Ile Phe Asn Glu Ala Gly Pro Asp Phe Gln Ile Lys Val Glu Val 
                165                 170                 175     


Tyr Ser Cys Cys Thr Glu Glu Ser Ser Ile Thr Asn Thr Pro Lys Lys 
            180                 185                 190         


Leu Ala Lys Lys Leu Lys Thr Ser Ile Ser Lys Ala Thr Gly Lys Lys 
        195                 200                 205             


Ile Ser Ser Val Leu Gln Glu Glu Asp Asp Glu Met Cys Leu Leu Leu 
    210                 215                 220                 


Ser Ser Ala Val Phe Gly Val Lys Tyr Asn Leu Leu Ala His Thr Thr 
225                 230                 235                 240 


Leu Thr Leu Glu Ser Ala Glu Asp Ser Phe Lys Thr His Asn Leu Ser 
                245                 250                 255     


Ile Asn Gly Asn Glu Glu Ser Ser Phe Trp Leu Pro Leu Tyr Gly Asn 
            260                 265                 270         


Met Cys Cys Arg Leu Val Ala Gln Pro Ala Cys Met Ala Glu Asp Ala 
        275                 280                 285             


Phe Ala Gly Phe Leu Asn Gln Gln Gln Met Val Glu Gly Leu Ile Ser 
    290                 295                 300                 


Trp Arg Arg Leu Tyr Cys Val Leu Arg Gly Gly Lys Leu Tyr Cys Phe 
305                 310                 315                 320 


Tyr Ser Pro Glu Glu Ile Glu Ala Lys Val Glu Pro Ala Leu Val Val 
                325                 330                 335     


Pro Ile Asn Lys Glu Thr Arg Ile Arg Ala Met Asp Lys Asp Ala Lys 
            340                 345                 350         


Lys Arg Ile His Asn Phe Ser Val Ile Asn Pro Val Pro Gly Gln Ala 
        355                 360                 365             


Ile Thr Gln Ile Phe Ala Val Asp Asn Arg Glu Asp Leu Gln Lys Trp 
    370                 375                 380                 


Met Glu Ala Phe Trp Gln His Phe Phe Asp Leu Ser Gln Trp Lys His 
385                 390                 395                 400 


Cys Cys Glu Glu Leu Met Lys Ile Glu Ile Met Ser Pro Arg Lys Pro 
                405                 410                 415     


Pro Leu Phe Leu Thr Lys Glu Ala Thr Ser Val Tyr His Asp Met Ser 
            420                 425                 430         


Ile Asp Ser Pro Met Lys Leu Glu Ser Leu Thr Asp Ile Ile Gln Lys 
        435                 440                 445             


Lys Ile Glu Glu Thr Asn Gly Gln Phe Leu Ile Gly Gln His Glu Glu 
    450                 455                 460                 


Ser Leu Pro Pro Pro Trp Ala Thr Leu Phe Asp Gly Asn His Gln Met 
465                 470                 475                 480 


Val Ile Gln Lys Lys Val Leu Tyr Pro Ala Ser Glu Pro Leu His Asp 
                485                 490                 495     


Glu Lys Gly Lys Lys Arg Gln Ala Pro Leu Pro Pro Ser Asp Lys Leu 
            500                 505                 510         


Pro Phe Ser Leu Lys Ser Gln Ser Asn Thr Asp Gln Leu Val Lys Asp 
        515                 520                 525             


Asn Trp Gly Lys Thr Ser Val Ser Gln Thr Ser Ser Leu Asp Thr Lys 
    530                 535                 540                 


Leu Ser Thr Leu Met His His Leu Gln Lys Pro Met Ala Ala Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Pro Ala Arg Arg Asn Arg Leu Ser Asp Gly Glu His Thr 
                565                 570                 575     


Asp Thr Lys Thr Asn Phe Glu Ala Lys Pro Val Pro Ala Pro Arg Gln 
            580                 585                 590         


Lys Ser Ile Lys Asp Ile Leu Asp Pro Arg Ser Trp Leu Gln Ala Gln 
        595                 600                 605             


Val 
    


<210>  1121
<211>  5553
<212>  DNA
<213>  Homo Sapiens

<400>  1121
gtgtgaatgc ttcattcgcc tcacaaacaa ccacagaacc acaagtgcgg tgcaaacttt       60

ctccaggagg acagcaagaa gtctctggtt tttaaatggt taatctccgc aggtcactac      120

cagccaccga gaccaacaga gtcatttaag gctgcaagca gtatttacaa cagagggtac      180

aagttctatc tgaaaaaaaa aggagggact atggcatcaa acagcctctt cagcacagtg      240

acaccatgtc agcaaaactt cttttgggat ccgagcacca gccggcgctt cagccccccc      300

tccagcagcc tgcagcccgg caaaatgagc gacgtgagcc cggtggtggc tgcgcaacag      360

cagcagcaac agcagcagca gcaacagcag cagcagcagc agcaacagca gcagcagcag      420

caggaggcgg cggcggcggc tgcggcggcg gcggcggctg cggcggcggc agctgcagtg      480

ccccggttgc ggccgcccca cgacaaccgc accatggtgg agatcatcgc cgaccacccg      540

gccgaactcg tccgcaccga cagccccaac ttcctgtgct cggtgctgcc ctcgcactgg      600

cgctgcaaca agaccctgcc cgtggccttc aaggtggtag ccctcggaga ggtaccagat      660

gggactgtgg ttactgtcat ggcgggtaac gatgaaaatt attctgctga gctccggaat      720

gcctctgctg ttatgaaaaa ccaagtagca aggttcaacg atctgagatt tgtgggccgg      780

agtggacgag gcaagagttt caccttgacc ataaccgtct tcacaaatcc tccccaagta      840

gctacctatc acagagcaat taaagttaca gtagatggac ctcgggaacc cagaaggcac      900

agacagaagc ttgatgactc taaacctagt ttgttctctg accgcctcag tgatttaggg      960

cgcattcctc atcccagtat gagagtaggt gtcccgcctc agaacccacg gccctccctg     1020

aactctgcac caagtccttt taatccacaa ggacagagtc agattacaga ccccaggcag     1080

gcacagtctt ccccgccgtg gtcctatgac cagtcttacc cctcctacct gagccagatg     1140

acgtccccgt ccatccactc taccaccccg ctgtcttcca cacggggcac tgggcttcct     1200

gccatcaccg atgtgcctag gcgcatttca gatgatgaca ctgccacctc tgacttctgc     1260

ctctggcctt ccactctcag taagaagagc caggcaggtg cttcagaact gggccctttt     1320

tcagacccca ggcagttccc aagcatttca tccctcactg agagccgctt ctccaaccca     1380

cgaatgcact atccagccac ctttacttac accccgccag tcacctcagg catgtccctc     1440

ggtatgtccg ccaccactca ctaccacacc tacctgccac caccctaccc cggctcttcc     1500

caaagccaga gtggaccctt ccagaccagc agcactccat atctctacta tggcacttcg     1560

tcaggatcct atcagtttcc catggtgccg gggggagacc ggtctccttc cagaatgctt     1620

ccgccatgca ccaccacctc gaatggcagc acgctattaa atccaaattt gcctaaccag     1680

aatgatggtg ttgacgctga tggaagccac agcagttccc caactgtttt gaattctagt     1740

ggcagaatgg atgaatctgt ttggcgacca tattgaaatt cctcagcagt ggcccagtgg     1800

tatctggggg ccacatccca cacgtatcaa tatatacata tatagagaga gtgcatatat     1860

atgtatatcg attagctatc tacaaagtgc ctatttttta gaagattttt cattcactca     1920

ctcagtcatg atcttgcagc cataagaggg tagatattga gaagcagaag gctcaagaga     1980

gacaattgca atcgagcttc agattgttta ctatttaaga tgtactttta caaaggaaca     2040

aagaagggaa aaggtatttt tgtttttgtt gtttggtctg ttatcatcaa taacctgttc     2100

atatgccaat tcagagaggt ggactccagg ttcaggaggg agaagagcaa agccgcttcc     2160

tctctgtgct ttgaaacttc acaccctcac ggtggcagct gtgtatggac cagtgccctc     2220

cgcagacagc tcacaaaacc agttgaggtg cactaaaggg acatgaggta gaatggatgc     2280

ttccatcaca gtaccatcat tcagaataac tcttccaatt tctgctttca gacatgctgc     2340

aggtcctcat ctgaactgtt gggttcgttt tttttttttt ttttcctgct ccaagaaagt     2400

gacttcaaaa ataactgatc aggatagatt attttatttt actttttaac actccttctc     2460

cccttttccc actgaaccaa aaagaaatcc catccctaaa acctgccttc tccttttatg     2520

caaaactgaa aatggcaata cattattata gccataatgg tatagatagt gattgcgttt     2580

ggctatgtgt tgttttcttt ttttttaaat tatgaatatg tgtaaaatct gaggtaactt     2640

gctaacgtga atggtcatat aactttaaag atatatttat aattatttaa tgacatttgg     2700

acccttgaaa catttcttag tgtattgata tgttgacttc ggtctctaaa agtgctcttt     2760

attaaataac aaatttcttc agtggtctag agccatatct gaaatattgc taagcaattt     2820

cagttcatcc aggcacaatg tgattttaaa aaatacttcc atctccaaat attttagata     2880

tagattgttt ttgtgatgta tgaaggaaat gttatgttta gttctttcag atctttgaat     2940

gcctctaaca cagctttgcc ttctaaagcg gtaattaggg atttaaaaaa caacctttag     3000

ccctttatca gcatgaaatg ctggagtgat gtggttttct aatttctttg gggtaattat     3060

gactcttgtc atattaaaaa gacaagcaca agtaaatcat tgaactacag aaaaatgttc     3120

tgtggtttca tagttaagca aaactctaaa tcgccaggct tcatagcaaa gacatagtca     3180

gctaaaagcc gcacatgtgg atagagggtt caattatgag acacctagta caggagagca     3240

aaattgcacc agagattctt aaccaaccag ccttaccaaa caacacaaca ggggaacccc     3300

aatctgcctt acccaaggcc ccactggcag ctttccacag aatttgcatt tagaggagca     3360

gaatgacatc actgtccttt gggagtaggt cctctgaaaa ggcagcaggt tccagcaggt     3420

agctgagctg agaggacata tggcccacgg ggacctacag acagcctttg acatttgtat     3480

ttcttacaat ggagggccaa ggagggcaag gggctgtgga gtttggtgtc tactagtgtg     3540

tatgaatttg agctagagtc cttctgtggc atgcactttg accactcctg gcagtcacat     3600

ggcagatttc caagtgcaaa tccttaatcc aaacaaggat catctaatga caccaccagg     3660

ccaatccctg ctctcctccc cgaaaagtca gggtcccttc attggaatcc tccacccacc     3720

caagcagaat ttagcagaga tttgccttca aaccctaacg gcccccttgt tctctggtcc     3780

ttctcaaacc cacctttgta ggccacccag cattgcagga cagcgtgtgg ggcagctgga     3840

cctgtgcttc ctgcctggga gtctcccttg gaattcatcc tgactccttc taataaaaat     3900

ggatgggaaa gcaaaacact ttgccttcta aaggccgtat accaagtatg cttagataaa     3960

taagccactt ttctattact taagtaagaa ggaagtagta attgatacta tttattgttt     4020

gtgtgtggta gcttgaagca caccactgtc catttatttg taagtgtaaa atatgtgtgt     4080

ttgtttcagc agcacttaaa aaagccagtg tctggttaca catttcaatt ttaattaatt     4140

gacataaaaa tgctaccgcc agtgccagct gcatcctatt taattaaaaa ggtactatat     4200

ttgtacatta ttttttaatg ttaaaagggc ttttttaagt ttacagtaca cataccgagt     4260

gactttaggg atgcttttgt gttgaaatgt tactatagtg gctgcaggca gcaacccaga     4320

aacactttag aagctttttt tccttgggaa aaattcaagc acttcttccc tccaccctca     4380

ctccaaccac cccaatgggg gtaattcaca tttcttagaa caaattctgc ccttttttgg     4440

tctagggatt aaaattttgt ttttctttct ttcttttttt ttttttttca ctgaaccctt     4500

aatttgcact gggtcatgtg tttgatttgt gatttcaaga ccaaagcaaa gtcttactac     4560

tactgtggaa ccatgtacta gttcctggga attaaaatag cgtggttctc tttgtagcac     4620

aaacattgct ggaatttgca gtcttttcaa tgcagccaca tttttatcca tttcagttgt     4680

ctcacaaatt ttaacccata tcagagttcc agaacaggta ccacagcttt ggttttagat     4740

tagtggaata acattcagcc cagaactgag aaactcaaca gattaactat cgtttgctct     4800

ttagacggtc tcactgcctc tcacttgcca gagccctttc aaaatgagca gagaagtcca     4860

caccattagg gaccatctgt gataaattca gaagggagga gatgtgtgta cagctttaag     4920

gattccctca attccgagga aagggactgg cccagaatcc aggttaatac atggaaacac     4980

gaagcattag caaaagtaat aattatacct atggtatttg aaagaacaat aataaaagac     5040

acttcttcca aaccttgaat ttgttgtttt tagaaaacga atgcatttaa aaatattttc     5100

tatgtgagaa ttttttagat gtgtgtttac ttcatgttta caaataactg tttgcttttt     5160

aatgcagtac tttgaaatat atcagccaaa accataactt acaataattt cttaggtatt     5220

ctgaataaaa ttccatttct tttggatatg ctttaccatt cttaggtttc tgtggaacaa     5280

aaatatttgt agcattttgt gtaaatacaa gctttcattt ttattttttc caattgctat     5340

tgcccaagaa ttgctttcca tgcacatatt gtaaaaattc cgctttgtgc cacaggtcat     5400

gattgtggat gagtttactc ttaacttcaa agggactatt tgtattgtat gttgcaactg     5460

taaattgaat tatttggcat ttttctcatg attgtaatat taatttgaag tttgaattta     5520

attttcaata aaatggcttt tttggttttg tta                                  5553


<210>  1122
<211>  521
<212>  PRT
<213>  Homo Sapiens

<400>  1122

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp 
            340                 345                 350         


Pro Ser Thr Leu Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly 
        355                 360                 365             


Pro Phe Ser Asp Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu 
    370                 375                 380                 


Ser Arg Phe Ser Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr 
385                 390                 395                 400 


Thr Pro Pro Val Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr 
                405                 410                 415     


His Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser 
            420                 425                 430         


Gln Ser Gly Pro Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly 
        435                 440                 445             


Thr Ser Ser Gly Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg 
    450                 455                 460                 


Ser Pro Ser Arg Met Leu Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser 
465                 470                 475                 480 


Thr Leu Leu Asn Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala 
                485                 490                 495     


Asp Gly Ser His Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg 
            500                 505                 510         


Met Asp Glu Ser Val Trp Arg Pro Tyr 
        515                 520     


<210>  1123
<211>  4540
<212>  DNA
<213>  Homo Sapiens

<400>  1123
gaatgcatta gtctaatgag atgtttgcag ctggagcgca gggctgctgg agactaactg       60

tgagctacta acacgggtgg aagatagctt ttgcaatact cggtttgcat gtgctgaaag      120

tcatctgtct tctgagtcaa cactcccgac ctggtaaaca acctgctcag ggctctggtg      180

aacaagctgt agcacctctt ctgcctgtga gcgatttgtc acctcattct gtaagactgg      240

caccagcaga aatgcagtct caaaggatcc cggggagaaa gcgaggccga ccctcacttc      300

actccacgcc tatgaagatg gcagttcata acctttattc tgcttcagct ggctctttac      360

cagcagtgaa gatcccaaag aaaagagggc ggaaacccgg gtacaagatc aagtctcggg      420

ttctcatgac tcccttagcc ctctcacctc cgcggagtac cccagagccc gacctcagct      480

ccatccctca ggacgcagcc acggtcccca gcttggcggc cccacaggct ctcacagtct      540

gcctctacat caacaagcag gccaatgcgg ggccctatct ggagaggaag aaggtgcagc      600

agctcccgga gcattttggg cccgagcggc catcggcggt gctgcagcag gccgtccaag      660

cctgcatcga ctgcgcccac cagcagaagc tggtcttctc cctggtcaag cagggctatg      720

gtggtgagat ggtgtcagtc tcggcttcct ttgatggcaa acagcacctg cggagcctgc      780

ctgtggtgaa cagcatcggc tatgtcctcc gcttcctcgc caagctgtgc cgaagcctcc      840

tgtgcgatga cctcttcagc caccagccct tccccagggg ctgcagtgcc tctgagaaag      900

tccaggagaa agaggaaggg aggatggaat cagtcaagac agtcaccacc gaagagtacc      960

tggtgaaccc tgtgggcatg aaccgctaca gcgtggacac ctccgcctcc acctttaacc     1020

acaggggctc cttgcacccc tcctcctcgc tgtactgcaa gaggcagaac tctggagaca     1080

gccaccttgg gggtggtcct gctgccaccg ctggtggtcc ccgcactagc cccatgtctt     1140

ctggtggccc ctcggcacct gggctgaggc ctccagcctc cagccccaag agaaacacga     1200

cctctcttga aggaaacaga tgtgcctcaa gcccttctca ggatgcgcag gatgccaggc     1260

ggccacggag caggaacccc tccgcctgga ctgtggagga cgtggtgtgg tttgtgaagg     1320

acgccgaccc acaggctctg gggcctcacg tggagctctt cagaaagcac gagattgatg     1380

gcaacgctct gctgttgctg aagagtgaca tggtcatgaa gtacctgggc ctgaagctgg     1440

gacctgcact gaaactctgc taccacattg acaaactgaa gcaagccaag ttctgacttt     1500

tttaaaaaga cagaagcgaa acccaaaaca acagatccca agattatctt ctgccttacc     1560

aatatcccgc caacatcaca aactagactc tcctcttaaa attaacagcc acagagacgt     1620

ggtcttttta taaaacttgt gaatctttgc cttttgaaga atttaacatg gaccttttcg     1680

agaggctcct ctgtgttcat aatttgccaa aaaattacaa aagcctgtga tttttaacat     1740

ccctgttatg ctggtttctc ttaaagtggg tcctatttgc ataacgagag agtggggaac     1800

tgaatgctta tgcccaagga gagttctgga gggttcaaag gatgaaagaa ggacctttgt     1860

ccctgcggtc tctgcaggga caaccccctc agcaccatct gcctctaact ctgacctggg     1920

gacctatcca tgtgagcctt gtttgcctca gctctggaag ctgacttctg aagatgactg     1980

cctcaccttg cactgtctgg aaaacttgaa ttattttacg ccgtgaaaga aaaaggaaaa     2040

aaaaaaaaat cttttctgtt cctagaaaat ctgaagtact gtgtttctcc gctagagggc     2100

agactgctaa tgaaatttca ggaccctcac tgactgcagt agcaggattg ttcagtactg     2160

agtggatggg ttagggtgtc tgtgaacaag atctagccca cacagaaaca ggggatttat     2220

tccacagtta gcaccacaga ttgcgacttg ggaagaaacc atcagctaga ggggtctagt     2280

tcgtatccaa tcattattga ctgactgact gatactcaac tagcaaaggc aagaatttgg     2340

aagcacgctc tacccagatg ggactttgga gttccttccc ttccagagtc cttattgagg     2400

tgttgaagtg ttggcatgcc gaagaatctt agtgacattt agccatgggt gtttctttaa     2460

aaaaggaaaa gaaaatgtct caacgaagct ttgaaatggg agagtgttga tttctagtta     2520

cattgctggg ttatgtagtt gtatctgtgg ctaatttttc tagtcctcaa caaatacaca     2580

gacatgctat tatggggttt aattcaattt acaaataggt tttccttcct cacagtggag     2640

taatagaaaa aattgatttt ctgctccttt gcagctgtgt ccagagacgg acaatgaatc     2700

cacaatttat taggcagagg cacaacttct ccaccattcg ttttatcctt ctcttttctc     2760

tgtttccctc cacctctctt cttcttcttt cacactgagc agaaaacata tcttcaaaat     2820

gaattcgcct ttgccatgtg catattctct tccttaaaag gacatcaaca gtgttggaga     2880

tgaggagatg aacattagat tttggaattt ctgggaggga gagggttagg gatgactcag     2940

ggcctccctt cgcccaaagg tgaatcagaa aaggcacccc tttctctggg atacaacctg     3000

agcaggggtc tcagctggca agtggagcag ggtgggggct caacctcctc accgcttgat     3060

cagctgccgt tgtacagagc atgacctgta taaccttgag ggcagccctg ggtagatctg     3120

cagagtgacc ctctatatag ttagaatcca gatgaaggcc ataagaaata gtccatgcca     3180

tgccgttagg cccactttca tgtgcagtac ttgagaaagc acatcgtagc ctccttttca     3240

gacacacaaa tggcggctgg actgagagca tggcagagaa ggggaggagg agaatgtact     3300

aaacttgctc actgaattga gcttgagtta ttagattgta gaagagcttg atgtctggtg     3360

attttgttac aggaaggggg tcccgatcca gaccccaaga gagggctctt ggatctcatg     3420

caagaaagaa ttcagggtga gtccataaag taaagtgaaa gcaagtttat taagaaagta     3480

aaggaaggaa agaatggcta ccccatagtc aaagcagctc tgagggctgc tggttgccca     3540

tttttatgtt tatttcttga tatgctaaac aaggggtgga ttattcatgc ctcccccttt     3600

tagatcatat agggtaactt cctgatgttg ccatggcatt tgtaaaccgt catggcactg     3660

gtggtagtat agcagcgagg acaaccagag gtcactctcg ttgccatctt ggttttggtg     3720

ggttttagcc aacttcttta ctgcaacctg ttttatcaga aggtctttat gacctatatc     3780

ttgtgctgac ctcctgtctc atcctgtgac tcagaatgct ttagccatct gggaatgcag     3840

cccagtaggt ctcagcctca ttttacccag ctcccattca agatggagtt gctctggttc     3900

aaatgcctct gacaggttca gcacctgaga aaagtacctt gaatcaggcc ttggggcaga     3960

gtcttcaaga ttttaaggtg atagggcctg tctcttaaga atttattaat cgtaagtgct     4020

cactgctggt ttagagttag atacatttcc ctcaaaacag ccatgggcag gttatgtact     4080

cagaactgcc agggtgaaaa caatgagatc cagaaaaatc ccacaacaat ccaggttttt     4140

cactcctctt ttttttctca atcttccgat acttgtggta cctcttccat caacagatac     4200

ctcatgtagt gacttccagt atcaagtttt caaaacttcc tacccaccct catcagtgcc     4260

tccttcacta cagagtcaca aacattggtg ctctcaaata aaaatcagcc ccaaacaatg     4320

tcaaagagat cccttgagta gttttcaggc gagagatatg ttctcatttc aagtcttgga     4380

gaaaactgga tccatgttca cgtggaactt ctctcgcgga ggtgctatct cattttgcat     4440

taaactttaa gcaggacaga ttgctgaagc catgatattt aaggtttgac tttttaaaaa     4500

tctcattact cttaaaataa atgctgccac atcagaaaaa                           4540


<210>  1124
<211>  414
<212>  PRT
<213>  Homo Sapiens

<400>  1124

Met Gln Ser Gln Arg Ile Pro Gly Arg Lys Arg Gly Arg Pro Ser Leu 
1               5                   10                  15      


His Ser Thr Pro Met Lys Met Ala Val His Asn Leu Tyr Ser Ala Ser 
            20                  25                  30          


Ala Gly Ser Leu Pro Ala Val Lys Ile Pro Lys Lys Arg Gly Arg Lys 
        35                  40                  45              


Pro Gly Tyr Lys Ile Lys Ser Arg Val Leu Met Thr Pro Leu Ala Leu 
    50                  55                  60                  


Ser Pro Pro Arg Ser Thr Pro Glu Pro Asp Leu Ser Ser Ile Pro Gln 
65                  70                  75                  80  


Asp Ala Ala Thr Val Pro Ser Leu Ala Ala Pro Gln Ala Leu Thr Val 
                85                  90                  95      


Cys Leu Tyr Ile Asn Lys Gln Ala Asn Ala Gly Pro Tyr Leu Glu Arg 
            100                 105                 110         


Lys Lys Val Gln Gln Leu Pro Glu His Phe Gly Pro Glu Arg Pro Ser 
        115                 120                 125             


Ala Val Leu Gln Gln Ala Val Gln Ala Cys Ile Asp Cys Ala His Gln 
    130                 135                 140                 


Gln Lys Leu Val Phe Ser Leu Val Lys Gln Gly Tyr Gly Gly Glu Met 
145                 150                 155                 160 


Val Ser Val Ser Ala Ser Phe Asp Gly Lys Gln His Leu Arg Ser Leu 
                165                 170                 175     


Pro Val Val Asn Ser Ile Gly Tyr Val Leu Arg Phe Leu Ala Lys Leu 
            180                 185                 190         


Cys Arg Ser Leu Leu Cys Asp Asp Leu Phe Ser His Gln Pro Phe Pro 
        195                 200                 205             


Arg Gly Cys Ser Ala Ser Glu Lys Val Gln Glu Lys Glu Glu Gly Arg 
    210                 215                 220                 


Met Glu Ser Val Lys Thr Val Thr Thr Glu Glu Tyr Leu Val Asn Pro 
225                 230                 235                 240 


Val Gly Met Asn Arg Tyr Ser Val Asp Thr Ser Ala Ser Thr Phe Asn 
                245                 250                 255     


His Arg Gly Ser Leu His Pro Ser Ser Ser Leu Tyr Cys Lys Arg Gln 
            260                 265                 270         


Asn Ser Gly Asp Ser His Leu Gly Gly Gly Pro Ala Ala Thr Ala Gly 
        275                 280                 285             


Gly Pro Arg Thr Ser Pro Met Ser Ser Gly Gly Pro Ser Ala Pro Gly 
    290                 295                 300                 


Leu Arg Pro Pro Ala Ser Ser Pro Lys Arg Asn Thr Thr Ser Leu Glu 
305                 310                 315                 320 


Gly Asn Arg Cys Ala Ser Ser Pro Ser Gln Asp Ala Gln Asp Ala Arg 
                325                 330                 335     


Arg Pro Arg Ser Arg Asn Pro Ser Ala Trp Thr Val Glu Asp Val Val 
            340                 345                 350         


Trp Phe Val Lys Asp Ala Asp Pro Gln Ala Leu Gly Pro His Val Glu 
        355                 360                 365             


Leu Phe Arg Lys His Glu Ile Asp Gly Asn Ala Leu Leu Leu Leu Lys 
    370                 375                 380                 


Ser Asp Met Val Met Lys Tyr Leu Gly Leu Lys Leu Gly Pro Ala Leu 
385                 390                 395                 400 


Lys Leu Cys Tyr His Ile Asp Lys Leu Lys Gln Ala Lys Phe 
                405                 410                 


<210>  1125
<211>  4656
<212>  DNA
<213>  Homo Sapiens

<400>  1125
gggcgggtgg gaggagagcg cgaaggggcg aggcccgttt gcaggggccg ctcggcccgg       60

ggaagcccgc gccccgctca gccttgcagc cccgcgcccg gagcatctcc ctggaggaac      120

ggagacaaag gaggattcat gtccaaaggg ctcccagaga ccaggacgga cgcagccatg      180

tcagagctgg tgcctgagcc caggcctaag ccagcggtgc ccatgaagcc catgagcatc      240

aactccaacc tgctgggcta catcggcatc gacaccatca tcgagcagat gcgcaagaag      300

accatgaaga ccggtttcga cttcaacatc atggtcgttg gccagagtgg actgggcaaa      360

tcaacgctgg tcaacacgct cttcaaatcc caagtgagcc gcaaggcctc cagctggaac      420

cgggaggaga agatccccaa gacagtggag atcaaagcta tcgggcatgt gatagaggaa      480

ggcggtgtca aaatgaagct gaccgtcatc gacaccccag gctttggaga ccaaatcaac      540

aatgaaaact gctgggagcc cattgagaag tacatcaatg agcagtacga gaagttcctg      600

aaggaggagg tcaacatcgc caggaagaaa cgcatccctg acactcgtgt ccactgctgc      660

ctttacttca tctctcccac aggacactcc ttgcgacctc tggatcttga gttcatgaaa      720

cacctcagca aggttgtgaa catcatccct gtcattgcta aggctgacac catgaccctg      780

gaggagaagt ctgaattcaa gcaaagggtt cgcaaggagc ttgaagtaaa tggcattgaa      840

ttctaccccc agaaggaatt tgatgaggat ttggaggata agacggagaa tgacaaaatc      900

aggcaggaga gcatgccttt tgctgtggtg ggaagtgaca aggagtacca agtgaatggc      960

aagagggtcc tcggccgaaa aactccatgg gggatcatcg aagtggaaaa cctcaaccac     1020

tgtgagtttg ccctgcttcg agactttgtc atcaggaccc acctccagga cctcaaggaa     1080

gtgacacaca acatccacta tgagacttac agggccaagc ggctcaatga caatggaggc     1140

ctccctccgg tgagcgtgga cacagaggaa agccacgaca gtaacccatg acgaccactt     1200

ctctgtgtca tcacacatac ccacttcaca cacacacatc ccaaatacca ccaccaacca     1260

ccttcttcct ctcaactctg tcccacaggc ctgtctggta tttgtggagc atcttgtctg     1320

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgac agagagagag cgagagagcc     1380

tgtgtgtgtg catgcagggg tgaggtattt tcactgccct ccctggagag tcccttgtaa     1440

gtttggctcc tccatgcctg tccattatct gtctcctttc cttgtgtccc aaaacaaagc     1500

tgtttgcctc actcaggaga tctgggggag gtttcattta aaagtgctgg gagcaggtga     1560

gccacaggca actcttctct cggaacctgc acacaaactg gggctataga gattctccaa     1620

ggacagatgg cagtggagct agacctgagt agggggcagg gagttcagga caaccctcct     1680

gtaagttggg ggtggtctgg gggtaaggct ggggcttcct gggaaaagga aggccatgag     1740

aaggcagaga agtaggccag agctgggttc ttgcagaaag catcagtgcc tacaaatgga     1800

gctccaccct tcagtctgtg tcgtgttcag tgtcacaaag ctaccacctg tcaccagagc     1860

ctactgctgc tctccactca actggcctct gctgccaggc cactgcctgt ctctgcttcc     1920

gactttgtct tctttctccc tttccctcct tccctcatac attgctttct ctccctctcc     1980

tgcgtgtctc tgacatctct cacttccttt tagatgaatc tactttaggt tcattcctat     2040

atttagcatt tatgcccagt ctacttccag aaatgacttt agactgcctt tcacataaaa     2100

tcacaaaact acaggacagt acaaacagat tgccagagaa atctgggtca aagaaaggaa     2160

taggaaagaa agtttctgta gtcaagcacc tgaacaggcc ctgagctcac aggcagccaa     2220

tgtaaagagg gaaacacagt gagttatgca gttcccagtg tccagttaaa ggaagcacac     2280

atgctagtca tgtgagacaa ccttttattg ggacatcagg ttctagaact aattctaaag     2340

aagtatcaga aacaatatac ataatttgtc tttcttagta atttggcttc aaagacaaat     2400

ttttgaccac acctccgttt tctccgtcag acttctctcc cttctaagca ggcttctctg     2460

ttgctccatt tgcttcatac atacttgacc tctcttttct attccccatc acttttgtgc     2520

tgaagctaat catatttatg tctgtctttc tctacttttc cctaattccc tctcctcctg     2580

actcctgtag acattcccaa tgatacccac cgtcatacat ttaggctttt cttgcctttc     2640

cctgaagccc tgtatttatt aatgcatata tttcccctgc ttgttgtaca agtaagttac     2700

tcttttcctt taatctgtaa gattcatgaa attcggggcc agggaaacag tttagcctta     2760

gggaagggaa aacactaagt gaaactgttt acaataacct catacaacct tctgtcccat     2820

ctcctggttc agcctaggtg tttcactggt cctctatgaa tcccagcact tataatccca     2880

gtcttttatc actcaggtgc taggaaaaaa aacatagact caagacccaa gattcaatgg     2940

accaggagaa aggggggcgg tgatcaggtc accagtgacc ccaacctatg ctctcggtct     3000

ttcctggagg ctgccaaccc agccctcatc ctcccttgct cacaaagtta cagggtaggc     3060

acctgtcagg acagaacagc agcagcgcta cagcccagag gttatacatt tcaacagaac     3120

agggatcctt ggctactgta gaagcagtcc tgtatggaga ccttggacca gcaggggaag     3180

atctatgggc atgggaggtg ggcgttggaa aggctgagta ggaatggtgc ctggcacccc     3240

tgaaccatga tctgagcctc cctggagaag gtattttata tgtctgctgc cagctgctgg     3300

tctccacacc ctcaaccgtt ctcaaccccc ctgcagggag aaggcctcct gggcactgtc     3360

cttccacctg tgccagccac cccctgcccc actgctgaat gaaggccatt tcaagcgctg     3420

cttctcactc cattcctctc agctgttatt gctgcagggc caagcccttt ttagtgctgt     3480

gctcgtccag ctcaccacca cagcccctct cagccctcag taggtgggag gggccagctg     3540

cctctttagg ccagttgcat cctccattta tccaaaccac tcctctcctc ccagtggagt     3600

ggggttctgc cagtacagcc ctactgcatc atctgcgtca gccggtccta gcccatctgc     3660

agggtgaaag aactcatcaa gagctccttc tgcccttgta agcccatccc agctacttgt     3720

aaccatctct aagggcaatg gcattgctcc ctacccattc atctgcatga gctactcttg     3780

gcttccttaa agggtcaaga aagcaatttt tctgcttact agattcattg agatcagctg     3840

tgtgagcccc aaagtgggac aagggtgtct ccttcattac ttaaagatat tcatgagggt     3900

gggtcactac agatgttggg gagcaagggc taggatcact ttttaaaaaa tcaccacttg     3960

tggctgtccc agagtgcggt tgtacatcct ccccacctca taacgcagcc actgaggaag     4020

agtggttttc ctaagaagac attgctggag ttgactttct tctgtccaaa caaacaaaca     4080

aaaactaaac acacacacaa acccccagaa acccacaata tgtacacgct aaggaaaaac     4140

tagcaccctt ctgtccactc agcaataaga gggatctctt cccacctacc ctacctactc     4200

ctacccccaa cccccttccc cattaatgtg agtaatgaat tagcctgacc acaggtggtc     4260

actgtaggct aatggaaaat acccaaggga gggcaaagcc ccccatcaga tgcatgaatg     4320

tttgcgaatg ttgactgcca ctgccccaca cactgtgtct ttatagaatt cccctttgcc     4380

caccctcttc ctgtctccac ctggacacaa cttgctcaaa ggctggtgac ttgtgggcca     4440

ttcatctaca accaagtcct gatggagcaa gaggcccacg cctaggggat gcaagaacaa     4500

cccgtttctt aaatgttacc agtcccagcc aatcttacgg tgacattaca gttaaatttc     4560

ccaattgaaa acaagcaaac agacactcaa actggtcctg taattgttgc tagactttat     4620

gtgttgtaca actaaacatt gctgtttgaa cagtaa                               4656


<210>  1126
<211>  350
<212>  PRT
<213>  Homo Sapiens

<400>  1126

Met Ser Lys Gly Leu Pro Glu Thr Arg Thr Asp Ala Ala Met Ser Glu 
1               5                   10                  15      


Leu Val Pro Glu Pro Arg Pro Lys Pro Ala Val Pro Met Lys Pro Met 
            20                  25                  30          


Ser Ile Asn Ser Asn Leu Leu Gly Tyr Ile Gly Ile Asp Thr Ile Ile 
        35                  40                  45              


Glu Gln Met Arg Lys Lys Thr Met Lys Thr Gly Phe Asp Phe Asn Ile 
    50                  55                  60                  


Met Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Thr 
65                  70                  75                  80  


Leu Phe Lys Ser Gln Val Ser Arg Lys Ala Ser Ser Trp Asn Arg Glu 
                85                  90                  95      


Glu Lys Ile Pro Lys Thr Val Glu Ile Lys Ala Ile Gly His Val Ile 
            100                 105                 110         


Glu Glu Gly Gly Val Lys Met Lys Leu Thr Val Ile Asp Thr Pro Gly 
        115                 120                 125             


Phe Gly Asp Gln Ile Asn Asn Glu Asn Cys Trp Glu Pro Ile Glu Lys 
    130                 135                 140                 


Tyr Ile Asn Glu Gln Tyr Glu Lys Phe Leu Lys Glu Glu Val Asn Ile 
145                 150                 155                 160 


Ala Arg Lys Lys Arg Ile Pro Asp Thr Arg Val His Cys Cys Leu Tyr 
                165                 170                 175     


Phe Ile Ser Pro Thr Gly His Ser Leu Arg Pro Leu Asp Leu Glu Phe 
            180                 185                 190         


Met Lys His Leu Ser Lys Val Val Asn Ile Ile Pro Val Ile Ala Lys 
        195                 200                 205             


Ala Asp Thr Met Thr Leu Glu Glu Lys Ser Glu Phe Lys Gln Arg Val 
    210                 215                 220                 


Arg Lys Glu Leu Glu Val Asn Gly Ile Glu Phe Tyr Pro Gln Lys Glu 
225                 230                 235                 240 


Phe Asp Glu Asp Leu Glu Asp Lys Thr Glu Asn Asp Lys Ile Arg Gln 
                245                 250                 255     


Glu Ser Met Pro Phe Ala Val Val Gly Ser Asp Lys Glu Tyr Gln Val 
            260                 265                 270         


Asn Gly Lys Arg Val Leu Gly Arg Lys Thr Pro Trp Gly Ile Ile Glu 
        275                 280                 285             


Val Glu Asn Leu Asn His Cys Glu Phe Ala Leu Leu Arg Asp Phe Val 
    290                 295                 300                 


Ile Arg Thr His Leu Gln Asp Leu Lys Glu Val Thr His Asn Ile His 
305                 310                 315                 320 


Tyr Glu Thr Tyr Arg Ala Lys Arg Leu Asn Asp Asn Gly Gly Leu Pro 
                325                 330                 335     


Pro Val Ser Val Asp Thr Glu Glu Ser His Asp Ser Asn Pro 
            340                 345                 350 


<210>  1127
<211>  2523
<212>  DNA
<213>  Homo Sapiens

<400>  1127
attactaagc atccccgtct gagtgcaagg gtgtgtgttg gcagtacagc cccaatcttg       60

caaaatcctt cttccaatgt tcctcccctc tctgtatgaa ccctgtgttg gggggcagaa      120

gatggaagcc cttggcaagc tcgatcgaac caagctacta aattgctgag ctcgttttaa      180

ctgaagtgtg agaaggaggt ttaaggcaag tagacaacat cctgttgttg gggtgcttct      240

ctcttttttg cacatctggc tgaactggga gtcaggtggt tgacttgtgc ctggctgcag      300

tagcagcggc atctcccttg cacagttctc ctcctcggcc tgcccaagag tccaccaggc      360

catggacgca gtggctgtgt atcatggcaa aatcagcagg gaaaccggcg agaagctcct      420

gcttgccact gggctggatg gcagctattt gctgagggac agcgagagcg tgccaggcgt      480

gtactgccta tgtgtgctgt atcacggtta catttataca taccgagtgt cccagacaga      540

aacaggttct tggagtgctg agacagcacc tggggtacat aaaagatatt tccggaaaat      600

aaaaaatctc atttcagcat ttcagaagcc agatcaaggc attgtaatac ctctgcagta      660

tccagttgag aagaagtcct cagctagaag tacacaaggt actacaggga taagagaaga      720

tcctgatgtc tgcctgaaag ccccatgaag aaaaataaaa caccttgtac tttattttct      780

ataatttaaa tatatgctaa gtcttatata ttgtagataa tacagttcgg tgagctacaa      840

atgcatttct aaagccattg tagtcctgta atggaagcat ctagcatgtc gtcaaagctg      900

aaatggactt ttgtacatag tgaggagctt tgaaacgagg attgggaaaa agtaattccg      960

taggttattt tcagttatta tatttacaaa tgggaaacaa aaggataatg aatactttat     1020

aaaggattaa tgtcaattct tgccaaatat aaataaaaat aatcctcagt ttttgtgaaa     1080

agctccattt ttagtgaaat attattttat agctactaat tttaaaatgt cttgcttgat     1140

tgtatggtgg gaagttggct ggtgtccctt gtctttgcca agttctccac tagctatggt     1200

gtcataggct cttttgggat ttttgaagct gtatactgtg tgctaaaaca agcactaaac     1260

aaagagtgaa ggatttatgt ttaattctga aagcaacctt cttgcctagt gttctgatat     1320

tggacagtaa aatccacaga ccaacctgga gttgaaaatc ttataattta aaatatgctc     1380

taaacatgtt tatcgtattt gatgctacag gatttgaaat tgtattacaa atccaatgaa     1440

atgagttttt cttttcattt acctctgccc cagttgtttc tactacatgg aagacctcat     1500

tttgaaggga aatttcagca gctgcagctc atgagtaact gatttgtaac aagcctcctt     1560

ttaaagtaac cctacaaaac cactggaaag tttatggttg tattattttt taaaaaaatt     1620

ccaagtgatt gaaacctaca cgagatacag aattttatgc ggcattttct tctcacattt     1680

atatttttgt gattttgtga ttgattatat gtcactttgc tacagggctc acagaattca     1740

ttcactcaac aaacataata gggcgctgag ggcatagaag taaaaacacc tggtccctgc     1800

tctcagttca ctgtcttgtt ggacgagaaa acaataacga taaaagacag tgaaagaaaa     1860

taacgataaa agacagtgaa agaaaataac aataaaagac aaggaaaaaa taacaatgaa     1920

agttgataag tacatgataa gcgaggttcc ccgtgtgtag gtagatctgg tctttagagg     1980

cagatagata ggtcagtgca aatactctgg tccatgggcc atatgaaaag gctaagcttc     2040

actgtaaaat aataactggg aattctggat tgtgtatggg tgttggtgaa cttggtttta     2100

attagtgaac tgctgagaga cagagctatt ctccatgtac tggcaagacc tgatttctga     2160

gcatttaata tggatgccgt gggagtacaa aagtggagtg tggcctgagt aatgcattat     2220

gggtggttta ccatttcttg aggtaaaagc atcacatgaa cttgtaaagg aatttaaaaa     2280

tcctactttc ataataagtt gcataggttt aataattttt aattatatgg cttgagttta     2340

aattgtaata ggcgtaacta attttaactc tataatgtgt tcattctgga ataatcctaa     2400

acatatgaat tatgtttgca tgttcacttc caagagcctt tttttgaaaa aaagcttttt     2460

ttgaatcatc aagtctttca catttaaata aagtgtttga aagctttatt tacctaaaaa     2520

aaa                                                                   2523


<210>  1128
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  1128

Met Asp Ala Val Ala Val Tyr His Gly Lys Ile Ser Arg Glu Thr Gly 
1               5                   10                  15      


Glu Lys Leu Leu Leu Ala Thr Gly Leu Asp Gly Ser Tyr Leu Leu Arg 
            20                  25                  30          


Asp Ser Glu Ser Val Pro Gly Val Tyr Cys Leu Cys Val Leu Tyr His 
        35                  40                  45              


Gly Tyr Ile Tyr Thr Tyr Arg Val Ser Gln Thr Glu Thr Gly Ser Trp 
    50                  55                  60                  


Ser Ala Glu Thr Ala Pro Gly Val His Lys Arg Tyr Phe Arg Lys Ile 
65                  70                  75                  80  


Lys Asn Leu Ile Ser Ala Phe Gln Lys Pro Asp Gln Gly Ile Val Ile 
                85                  90                  95      


Pro Leu Gln Tyr Pro Val Glu Lys Lys Ser Ser Ala Arg Ser Thr Gln 
            100                 105                 110         


Gly Thr Thr Gly Ile Arg Glu Asp Pro Asp Val Cys Leu Lys Ala Pro 
        115                 120                 125             


<210>  1129
<211>  4001
<212>  DNA
<213>  Homo Sapiens

<400>  1129
ctcctccttc ccccaaccac ccgcgcagtc acaaccggtt cagactggcc ggggtgcccc       60

gcaaagagag acaagggaga aaaagacagc agggaaaacc ccggggagga gaaggcgaaa      120

gagaaggtgg agctcagaga agggggccgg ctccccagct ccatgtggcc gccgccgctg      180

cgggtctgtg ggggcagagg gcggcggctc ccggggcagc gcgtagcggg accgattgcc      240

taatactccg gcaggggccg gggccgcagc tggctcggat aaatagccgc ccggctggcc      300

cggagctgca ggggagagcg gcggccgcga tccccaccac accaccagcc cggccgcacg      360

gggcactgag ccgggtgctg agcaccggag gccccgccga ggccgggact caggacctgc      420

agagaaacgc ctcctgattt tgtcttacaa tggaacttaa aaagtcgcct gacggtggat      480

ggggctgggt gattgtgttt gtctccttcc ttactcagtt tttgtgttac ggatccccac      540

tagctgttgg agtcctgtac atagaatggc tggatgcctt tggtgaagga aaaggaaaaa      600

cagcctgggt tggatccctg gcaagtggag ttggcttgct tgcaagtcct gtctgcagtc      660

tctgtgtctc atcttttgga gcaagacctg tcacaatctt cagtggcttc atggtggctg      720

gaggcctgat gttgagcagt tttgctccca atatctactt tctgtttttt tcctatggca      780

ttgttgtagg tcttggatgt ggtttattat acactgcaac agtgaccatt acgtgccagt      840

attttgacga tcgccgaggc ctagcgcttg gcctgatttc aacaggttca agcgttggcc      900

ttttcatata tgctgctctg cagaggatgc tggttgagtt ctatggactg gatggatgct      960

tgctgattgt gggtgcttta gctttaaata tattagcctg tggcagtctg atgagacccc     1020

tccaatcttc tgattgtcct ttgcctaaaa aaatagctcc agaagatcta ccagataaat     1080

actccattta caatgaaaaa ggaaagaatc tggaagaaaa cataaacatt cttgacaaga     1140

gctacagtag tgaggaaaaa tgcaggatca cgttagccaa tggtgactgg aaacaagaca     1200

gcctacttca taaaaacccc acagtgacac acacaaaaga gcctgaaacg tacaaaaaga     1260

aagttgcaga acagacatat ttttgcaaac agcttgccaa gaggaagtgg cagttatata     1320

aaaactactg tggtgaaact gtggctcttt ttaaaaacaa agtattttca gcccttttca     1380

ttgctatctt actctttgac atcggagggt ttccaccttc attacttatg gaagatgtag     1440

caagaagttc aaacgtgaaa gaagaagagt ttattatgcc acttatttcc attataggca     1500

ttatgacagc agttggtaaa ctgcttttag ggatactggc tgacttcaag tggattaata     1560

ccttgtatct ttatgttgct accttaatca tcatgggcct agccttgtgt gcaattccat     1620

ttgccaaaag ctatgtcaca ttggcgttgc tttctgggat cctagggttt cttactggta     1680

attggtccat ctttccatat gtgaccacga agactgtggg aattgaaaaa ttagcccatg     1740

cctatgggat attaatgttc tttgctggac ttggaaatag cctaggacca cccatcgttg     1800

gttggtttta tgactggacc cagacctatg atattgcatt ttattttagt ggcttctgcg     1860

tcctgctggg aggttttatt ctgctgctgg cagccttgcc ctcttgggat acatgcaaca     1920

agcaactccc caagccagct ccaacaactt tcttgtacaa agttgcctct aatgtttaga     1980

agaatattgg aagacactat ttttgctatt ttataccata tagcaacgat attttaacag     2040

attctcaagc aaattttcta gagtcaagac tattttctca tagcaaaatt tcacaatgac     2100

tgactctgaa tgaattattt ttttttatat atcctatttt ttatgtagtg tatgcgtagc     2160

ctctatctcg tatttttttc tatttctcct ccccacacca tcaatgggac tattctgttt     2220

tgctgttatt cactagttct taacattgta aaaagtttga ccagcctcag aaggctttct     2280

ctgtgtaaag aagtataatt tctctgccga ctccatttaa tccactgcaa ggcacctaga     2340

gagactgctc ctattttaaa agtgatgcaa gcatcatgat aagatatgtg tgaagcccac     2400

taggaaataa atcattctct tctctatgtt tgacttgcta gtaaacagaa gacttcaagc     2460

cagccaggaa attaaagtgg cgactaaaac agccttaaga attgcagtgg agcaaattgg     2520

tcatttttta aaaaaatata ttttaaccta cagtcaccag ttttcattat tctatttacc     2580

tcactgaagt actcgcatgt tgtttggtac ccactgagca actgtttcag ttcctaaggt     2640

atttgctgag atgtgggtga actccaaatg gagaagtagt cactgtagac tttcttcatg     2700

gttgaccact ccaaccttgc tcacttttgc ttcttggcca tccactcagc tgatgtttcc     2760

tgggaagtgc taattttacc tgtttccaaa ttggaaacac atttctcaat cattccgttc     2820

tggcaaatgg gaaacatcca tttgctttgg gcacagtggg gatgggctgc aagttcttgc     2880

atatcctccc agtgaagcat ttatttgcta ctatcagatt ttaccactat caaatataat     2940

tcaagggcag aattaaacgt gagtgtgtgt gtgtgtgtgt gtgtgtgcta tgcatgctct     3000

aagtctgcat gggatatggg aatggaaaag ggcaataaga aattaatacc cttatgcagt     3060

tgcatttaac cttaagaaaa atgtccttgg gataaactcc aatgtttaat acattgattt     3120

tttttctaaa gaaatgggtt ttaaactttg gtatgcatca gaattcccta tagatctttt     3180

tgaaaatata ggtacctggg tatcacacat agaactttta attctgctgg tgtaggctgt     3240

tgcccaaaca tctataattt tactgagctc ttcaagtgat tctgataaca cagcctggat     3300

tgagaatttt tataagattg gcaatggaaa aacatttatt cttttaaata ataatttttt     3360

taaaacccaa gaggtcaggg gattttataa accaatagcc aagtgttctt taaataggag     3420

gcacccttcc cattgtgcca aaatcatctt ttcatttatt ttgaaatttg tatgattatt     3480

ttatacttgt atgttgcctt tcttcgaagg cgcctgaagc actttataaa cacaaatcct     3540

cacaatacct ctgtgaggta ggtaaatagt acttttctat gtagtaaacc tggaatatgg     3600

agaatttcat aacagttcat tctacttaat aatgcaataa tggagctcca agttgtcttg     3660

gacttctaca ccacactcag acttctggaa agttttctgt acctcattct ttagtccctg     3720

tcaaggttag taaataaaat aagtgacata aaaaaaaaaa aaactaaact acttgttgtg     3780

ttgaaagttc ctttttgcca gttatgttca ggaaacccaa taacctgaaa aagtttgact     3840

ttgatgtgac atcttcatat tcatcaatgc tgataattgt ccaaaggcat cttcactatg     3900

tctgctaaat aacatccaat gtgggcgtta tctgttgtct aggggatgaa ttttaagtta     3960

caataaaata tttttctttg ttttgcaaaa aaaaaaaaaa a                         4001


<210>  1130
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  1130

Met Glu Leu Lys Lys Ser Pro Asp Gly Gly Trp Gly Trp Val Ile Val 
1               5                   10                  15      


Phe Val Ser Phe Leu Thr Gln Phe Leu Cys Tyr Gly Ser Pro Leu Ala 
            20                  25                  30          


Val Gly Val Leu Tyr Ile Glu Trp Leu Asp Ala Phe Gly Glu Gly Lys 
        35                  40                  45              


Gly Lys Thr Ala Trp Val Gly Ser Leu Ala Ser Gly Val Gly Leu Leu 
    50                  55                  60                  


Ala Ser Pro Val Cys Ser Leu Cys Val Ser Ser Phe Gly Ala Arg Pro 
65                  70                  75                  80  


Val Thr Ile Phe Ser Gly Phe Met Val Ala Gly Gly Leu Met Leu Ser 
                85                  90                  95      


Ser Phe Ala Pro Asn Ile Tyr Phe Leu Phe Phe Ser Tyr Gly Ile Val 
            100                 105                 110         


Val Gly Leu Gly Cys Gly Leu Leu Tyr Thr Ala Thr Val Thr Ile Thr 
        115                 120                 125             


Cys Gln Tyr Phe Asp Asp Arg Arg Gly Leu Ala Leu Gly Leu Ile Ser 
    130                 135                 140                 


Thr Gly Ser Ser Val Gly Leu Phe Ile Tyr Ala Ala Leu Gln Arg Met 
145                 150                 155                 160 


Leu Val Glu Phe Tyr Gly Leu Asp Gly Cys Leu Leu Ile Val Gly Ala 
                165                 170                 175     


Leu Ala Leu Asn Ile Leu Ala Cys Gly Ser Leu Met Arg Pro Leu Gln 
            180                 185                 190         


Ser Ser Asp Cys Pro Leu Pro Lys Lys Ile Ala Pro Glu Asp Leu Pro 
        195                 200                 205             


Asp Lys Tyr Ser Ile Tyr Asn Glu Lys Gly Lys Asn Leu Glu Glu Asn 
    210                 215                 220                 


Ile Asn Ile Leu Asp Lys Ser Tyr Ser Ser Glu Glu Lys Cys Arg Ile 
225                 230                 235                 240 


Thr Leu Ala Asn Gly Asp Trp Lys Gln Asp Ser Leu Leu His Lys Asn 
                245                 250                 255     


Pro Thr Val Thr His Thr Lys Glu Pro Glu Thr Tyr Lys Lys Lys Val 
            260                 265                 270         


Ala Glu Gln Thr Tyr Phe Cys Lys Gln Leu Ala Lys Arg Lys Trp Gln 
        275                 280                 285             


Leu Tyr Lys Asn Tyr Cys Gly Glu Thr Val Ala Leu Phe Lys Asn Lys 
    290                 295                 300                 


Val Phe Ser Ala Leu Phe Ile Ala Ile Leu Leu Phe Asp Ile Gly Gly 
305                 310                 315                 320 


Phe Pro Pro Ser Leu Leu Met Glu Asp Val Ala Arg Ser Ser Asn Val 
                325                 330                 335     


Lys Glu Glu Glu Phe Ile Met Pro Leu Ile Ser Ile Ile Gly Ile Met 
            340                 345                 350         


Thr Ala Val Gly Lys Leu Leu Leu Gly Ile Leu Ala Asp Phe Lys Trp 
        355                 360                 365             


Ile Asn Thr Leu Tyr Leu Tyr Val Ala Thr Leu Ile Ile Met Gly Leu 
    370                 375                 380                 


Ala Leu Cys Ala Ile Pro Phe Ala Lys Ser Tyr Val Thr Leu Ala Leu 
385                 390                 395                 400 


Leu Ser Gly Ile Leu Gly Phe Leu Thr Gly Asn Trp Ser Ile Phe Pro 
                405                 410                 415     


Tyr Val Thr Thr Lys Thr Val Gly Ile Glu Lys Leu Ala His Ala Tyr 
            420                 425                 430         


Gly Ile Leu Met Phe Phe Ala Gly Leu Gly Asn Ser Leu Gly Pro Pro 
        435                 440                 445             


Ile Val Gly Trp Phe Tyr Asp Trp Thr Gln Thr Tyr Asp Ile Ala Phe 
    450                 455                 460                 


Tyr Phe Ser Gly Phe Cys Val Leu Leu Gly Gly Phe Ile Leu Leu Leu 
465                 470                 475                 480 


Ala Ala Leu Pro Ser Trp Asp Thr Cys Asn Lys Gln Leu Pro Lys Pro 
                485                 490                 495     


Ala Pro Thr Thr Phe Leu Tyr Lys Val Ala Ser Asn Val 
            500                 505                 


<210>  1131
<211>  2796
<212>  DNA
<213>  Homo Sapiens

<400>  1131
ctgcggcggg ggcggcccca gcggatgaat gaagcggcgc gtggctgccg gggaggccag       60

agcgtggagc gctgcgcggc gcggcggccg ggccctcgag acggggacgg acacaccagc      120

ccctcggata ccacttggcc actcccgctg aggccactcc cactgcgtgg ctgaagcctc      180

gaggtcacca ggcggaggcg cggagatgcc cctgcatcag ctgggggaca agccgctcac      240

cttccccagc cccaactcag ccatggaaaa cgggcttgac cacaccccac ccagcaggag      300

ggcatccccg ggcacacccc tgagccccgg ctccctccgc tccgctgccc atagccccct      360

ggacaccagc aagcagcccc tctgccagct ctgggccgag aagcatggcg cccgggggac      420

ccatgaggtg cggtacgtct cggccgggca gagcgtggcg tgcggctggt gggccttcgc      480

accgccgtgc ctgcaggtcc tcaacacgcc caagggcatc ctgttcttcc tgtgtgcggc      540

cgcattcctg caggggatga ctgtgaatgg cttcatcaac acagtcatca cctccctgga      600

gcgccgctat gacctgcaca gctaccagag cgggctcatc gccagctcct acgacattgc      660

cgcctgcctc tgcctcacct tcgtcagcta cttcgggggc tcagggcaca agccgcgctg      720

gctgggctgg ggcgtgctgc ttatgggcac ggggtcgctg gtgttcgcgc tgccccactt      780

cacggctggc cgctatgagg tggagttgga cgcgggtgtc aggacgtgcc ctgccaaccc      840

cggcgcggtg tgtgcggaca gcacctcggg cctgtcccgc taccagctgg tcttcatgct      900

gggccagttc ctgcatggcg tgggtgccac acccctctac acgctgggcg tcacctacct      960

ggatgagaac gtcaagtcca gctgctcgcc cgtctacatt gccatcttct acacagcggc     1020

catcctgggc ccagctgccg gctacctgat tggaggtgcc ctgctgaata tctacacgga     1080

aatgggccga cggacggagc tgaccaccga gagcccactg tgggtcggcg cctggtgggt     1140

cggcttcctg ggctctgggg ccgctgcttt cttcaccgcc gttcccatcc ttggttaccc     1200

tcggcagctg ccaggctccc agcgctacgc ggtcatgaga gcggcggaaa tgcaccagtt     1260

gaaggacagc agccgtgggg aggcgagcaa cccggacttt gggaaaacca tcagagacct     1320

gcctctctcc atctggctcc tgctgaagaa ccccacgttc atcctgctct gcctggccgg     1380

ggccaccgag gccactctca tcaccggcat gtccacgttc agccccaagt tcttggagtc     1440

ccagttcagc ctgagtgcct cagaagctgc caccttgttt gggtacctgg tggtgccagc     1500

gggtggtggc ggcaccttcc tgggcggctt ctttgtgaac aagctcaggc tccggggctc     1560

cgcggtcatc aagttctgcc tgttctgcac cgttgtcagc ctgctgggca tcctcgtctt     1620

ctcactgcac tgccccagtg tgcccatggc gggcgtcaca gccagctacg gcgggagcct     1680

cctgcccgaa ggccacctga acctaacggc tccctgcaac gctgcctgca gctgccagcc     1740

agaacactac agccctgtgt gcggctcgga cggcctcatg tacttctcac tgtgccacgc     1800

agggtgccct gcagccacgg agacgaatgt ggacggccag aaggtgtacc gagactgtag     1860

ctgtatccct cagaatcttt cctctggttt tggccatgcc actgcaggga aatgcacttc     1920

aacttgtcag agaaagcccc tccttctggt tttcatattc gttgtaattt tctttacatt     1980

cctcagcagc attcctgcac taacggcaac tctacgatgt gtccgtgacc ctcagagatc     2040

ctttgccctg ggaatccagt ggattgtagt tagaatacta gggggcatcc cggggcccat     2100

cgccttcggc tgggtgatcg acaaggcctg tctgctgtgg caggaccagt gtggccagca     2160

gggctcctgc ttggtgtacc agaattcggc catgagccgc tacatactca tcatggggct     2220

cctgtacaag gtgctgggcg tcctcttctt tgccatagcc tgcttcttat acaagcccct     2280

gtcggagtct tcagatggcc tggaaacttg tctgcccagc cagtcctcag cccctgacag     2340

tgccacagat agccagctcc agagcagcgt ctgaccaccg cccgcgccca cccggccacg     2400

gcgggcactc agcatttcct gatgacagaa cagtgccgtt gggtgatgca atcacacggg     2460

aacttctatt tgacctgcaa ccttctactt aacctgtggt ttaaagtcgg ctgtgacctc     2520

ctgtccccag agctgtacgg ccctgcagtg ggtgggagga acttgcataa atatatattt     2580

atggacacac agtttgcatc agaacgtgtt tatagaatgt gttttatacc cgatcgtgtg     2640

tggtgtgcgt gaggacaaac tccgcagggg ctgtgaatcc cactgggagg gcggtgggcc     2700

tgcagcctga ggaaggcttg tgtgtcctca gttaaaactg tgcatatcga aatatatttt     2760

gttatttaag cctgcgaaaa aaaaaaaaaa aaaaaa                               2796


<210>  1132
<211>  722
<212>  PRT
<213>  Homo Sapiens

<400>  1132

Met Pro Leu His Gln Leu Gly Asp Lys Pro Leu Thr Phe Pro Ser Pro 
1               5                   10                  15      


Asn Ser Ala Met Glu Asn Gly Leu Asp His Thr Pro Pro Ser Arg Arg 
            20                  25                  30          


Ala Ser Pro Gly Thr Pro Leu Ser Pro Gly Ser Leu Arg Ser Ala Ala 
        35                  40                  45              


His Ser Pro Leu Asp Thr Ser Lys Gln Pro Leu Cys Gln Leu Trp Ala 
    50                  55                  60                  


Glu Lys His Gly Ala Arg Gly Thr His Glu Val Arg Tyr Val Ser Ala 
65                  70                  75                  80  


Gly Gln Ser Val Ala Cys Gly Trp Trp Ala Phe Ala Pro Pro Cys Leu 
                85                  90                  95      


Gln Val Leu Asn Thr Pro Lys Gly Ile Leu Phe Phe Leu Cys Ala Ala 
            100                 105                 110         


Ala Phe Leu Gln Gly Met Thr Val Asn Gly Phe Ile Asn Thr Val Ile 
        115                 120                 125             


Thr Ser Leu Glu Arg Arg Tyr Asp Leu His Ser Tyr Gln Ser Gly Leu 
    130                 135                 140                 


Ile Ala Ser Ser Tyr Asp Ile Ala Ala Cys Leu Cys Leu Thr Phe Val 
145                 150                 155                 160 


Ser Tyr Phe Gly Gly Ser Gly His Lys Pro Arg Trp Leu Gly Trp Gly 
                165                 170                 175     


Val Leu Leu Met Gly Thr Gly Ser Leu Val Phe Ala Leu Pro His Phe 
            180                 185                 190         


Thr Ala Gly Arg Tyr Glu Val Glu Leu Asp Ala Gly Val Arg Thr Cys 
        195                 200                 205             


Pro Ala Asn Pro Gly Ala Val Cys Ala Asp Ser Thr Ser Gly Leu Ser 
    210                 215                 220                 


Arg Tyr Gln Leu Val Phe Met Leu Gly Gln Phe Leu His Gly Val Gly 
225                 230                 235                 240 


Ala Thr Pro Leu Tyr Thr Leu Gly Val Thr Tyr Leu Asp Glu Asn Val 
                245                 250                 255     


Lys Ser Ser Cys Ser Pro Val Tyr Ile Ala Ile Phe Tyr Thr Ala Ala 
            260                 265                 270         


Ile Leu Gly Pro Ala Ala Gly Tyr Leu Ile Gly Gly Ala Leu Leu Asn 
        275                 280                 285             


Ile Tyr Thr Glu Met Gly Arg Arg Thr Glu Leu Thr Thr Glu Ser Pro 
    290                 295                 300                 


Leu Trp Val Gly Ala Trp Trp Val Gly Phe Leu Gly Ser Gly Ala Ala 
305                 310                 315                 320 


Ala Phe Phe Thr Ala Val Pro Ile Leu Gly Tyr Pro Arg Gln Leu Pro 
                325                 330                 335     


Gly Ser Gln Arg Tyr Ala Val Met Arg Ala Ala Glu Met His Gln Leu 
            340                 345                 350         


Lys Asp Ser Ser Arg Gly Glu Ala Ser Asn Pro Asp Phe Gly Lys Thr 
        355                 360                 365             


Ile Arg Asp Leu Pro Leu Ser Ile Trp Leu Leu Leu Lys Asn Pro Thr 
    370                 375                 380                 


Phe Ile Leu Leu Cys Leu Ala Gly Ala Thr Glu Ala Thr Leu Ile Thr 
385                 390                 395                 400 


Gly Met Ser Thr Phe Ser Pro Lys Phe Leu Glu Ser Gln Phe Ser Leu 
                405                 410                 415     


Ser Ala Ser Glu Ala Ala Thr Leu Phe Gly Tyr Leu Val Val Pro Ala 
            420                 425                 430         


Gly Gly Gly Gly Thr Phe Leu Gly Gly Phe Phe Val Asn Lys Leu Arg 
        435                 440                 445             


Leu Arg Gly Ser Ala Val Ile Lys Phe Cys Leu Phe Cys Thr Val Val 
    450                 455                 460                 


Ser Leu Leu Gly Ile Leu Val Phe Ser Leu His Cys Pro Ser Val Pro 
465                 470                 475                 480 


Met Ala Gly Val Thr Ala Ser Tyr Gly Gly Ser Leu Leu Pro Glu Gly 
                485                 490                 495     


His Leu Asn Leu Thr Ala Pro Cys Asn Ala Ala Cys Ser Cys Gln Pro 
            500                 505                 510         


Glu His Tyr Ser Pro Val Cys Gly Ser Asp Gly Leu Met Tyr Phe Ser 
        515                 520                 525             


Leu Cys His Ala Gly Cys Pro Ala Ala Thr Glu Thr Asn Val Asp Gly 
    530                 535                 540                 


Gln Lys Val Tyr Arg Asp Cys Ser Cys Ile Pro Gln Asn Leu Ser Ser 
545                 550                 555                 560 


Gly Phe Gly His Ala Thr Ala Gly Lys Cys Thr Ser Thr Cys Gln Arg 
                565                 570                 575     


Lys Pro Leu Leu Leu Val Phe Ile Phe Val Val Ile Phe Phe Thr Phe 
            580                 585                 590         


Leu Ser Ser Ile Pro Ala Leu Thr Ala Thr Leu Arg Cys Val Arg Asp 
        595                 600                 605             


Pro Gln Arg Ser Phe Ala Leu Gly Ile Gln Trp Ile Val Val Arg Ile 
    610                 615                 620                 


Leu Gly Gly Ile Pro Gly Pro Ile Ala Phe Gly Trp Val Ile Asp Lys 
625                 630                 635                 640 


Ala Cys Leu Leu Trp Gln Asp Gln Cys Gly Gln Gln Gly Ser Cys Leu 
                645                 650                 655     


Val Tyr Gln Asn Ser Ala Met Ser Arg Tyr Ile Leu Ile Met Gly Leu 
            660                 665                 670         


Leu Tyr Lys Val Leu Gly Val Leu Phe Phe Ala Ile Ala Cys Phe Leu 
        675                 680                 685             


Tyr Lys Pro Leu Ser Glu Ser Ser Asp Gly Leu Glu Thr Cys Leu Pro 
    690                 695                 700                 


Ser Gln Ser Ser Ala Pro Asp Ser Ala Thr Asp Ser Gln Leu Gln Ser 
705                 710                 715                 720 


Ser Val 
        


<210>  1133
<211>  1181
<212>  DNA
<213>  Homo Sapiens

<400>  1133
aaaaagccag ctgggctcct gagtccggcg ggtacttgga gaacttacta cgtctagctg       60

gaggattgta aatgcaccaa tcagcatgct gtgtctagct caagaactca agctccatga      120

ggagatgttt cattgtcgag agcagtcatg atgccctgca ctccacacaa tgcaacagag      180

tgaaagagca ggttctgctt ctttggtgta gtcctgaagc ttcctaagaa acttcacatc      240

aggtgatgga taggagcaac cctgtaaaac cagccttaga ctatttttca aacaggctgg      300

tgaattacca gatctccgtc aagtgcagta accagttcaa gttggaagtg tgtcttttga      360

atgcagaaaa caaagtcgtg gacaaccagg ctgggaccca gggccagctg aaggtgctgg      420

gtgccaacct ctggtggccg tacctgatgc acgaacaccc cgcctacctg tactcgtggg      480

aggatggtga ttgctcacac caaagccttg gacccctccc agcctgtgac ctttgggacc      540

aactccacct acgcagcaga caagggggct ctgtatgtgg atgtgatccg tgtgaacagc      600

tactactctt ggtatcgcaa ctacgggcac ctggagttga ttcagctgca gctggccgcc      660

cagtttgaga attggtgtaa gacatcacaa tcccattatt cagagcgcgt atggagtgga      720

aacgcttgta gggcttcacc aggatccacc tctgatgttc agtgaagagg accagaaaag      780

tctgctagag cagtaccatc tgggtctgga tcaaaaacgc agaaaatacg tggttggaga      840

gctcatctgg aattttgccg atttcatgac taaccagtgt gtcagtttct tggtcgggaa      900

tgaaaatagt gccaacctgt gataccttca ctctaatttt actttctgag gaagttttct      960

gtaatagtta tttggtgata attattaata ctgatgtgaa tttcttcgga gtaagaaatc     1020

ctcagaggaa attacccagt atatccaaag ctacaaggga tttgttgaca taacgggaga     1080

acattttgtg aattcctggg tccagagaga attacctatg gcatcagctt attgcaatga     1140

cagcatcttt gcttacgaag aactacggct ggactctttt a                         1181


<210>  1134
<211>  140
<212>  PRT
<213>  Homo Sapiens

<400>  1134

Met Asp Arg Ser Asn Pro Val Lys Pro Ala Leu Asp Tyr Phe Ser Asn 
1               5                   10                  15      


Arg Leu Val Asn Tyr Gln Ile Ser Val Lys Cys Ser Asn Gln Phe Lys 
            20                  25                  30          


Leu Glu Val Cys Leu Leu Asn Ala Glu Asn Lys Val Val Asp Asn Gln 
        35                  40                  45              


Ala Gly Thr Gln Gly Gln Leu Lys Val Leu Gly Ala Asn Leu Trp Trp 
    50                  55                  60                  


Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu Tyr Ser Trp Glu Asp 
65                  70                  75                  80  


Gly Asp Cys Ser His Gln Ser Leu Gly Pro Leu Pro Ala Cys Asp Leu 
                85                  90                  95      


Trp Asp Gln Leu His Leu Arg Ser Arg Gln Gly Gly Ser Val Cys Gly 
            100                 105                 110         


Cys Asp Pro Cys Glu Gln Leu Leu Leu Leu Val Ser Gln Leu Arg Ala 
        115                 120                 125             


Pro Gly Val Asp Ser Ala Ala Ala Gly Arg Pro Val 
    130                 135                 140 


<210>  1135
<211>  2397
<212>  DNA
<213>  Homo Sapiens

<400>  1135
cacgcgcccc tcctccgcat ctgagcgggg gagcggcggc ccccagctga atgggcgcga       60

gagcggcgct gggggcgggt gggggcgcgg ggtaccgggc tggcggccgg ccggcgcccc      120

ctcattagta tgcggacgaa ggcggcgggc tgcgcggagc ggcgtcccct gcagccgcgg      180

accgaggcag cggcggcacc tgccggccga gcaatgccaa gtgagtacac ctatgtgaaa      240

ctgagaagtg attgctcgag gccttccctg caatggtaca cccgagctca aagcaagatg      300

agaaggccca gcttgttatt aaaagacatc ctcaaatgta cattgcttgt gtttggagtg      360

tggatccttt atatcctcaa gttaaattat actactgaag aatgtgacat gaaaaaaatg      420

cattatgtgg accctgacca tgtaaagaga gctcagaaat atgctcagca agtcttgcag      480

aaggaatgtc gtcccaagtt tgccaagaca tcaatggcgc tgttatttga gcacaggtat      540

agcgtggact tactcccttt tgtgcagaag gcccccaaag acagtgaagc tgagtccaag      600

tacgatcctc cttttgggtt ccggaagttc tccagtaaag tccagaccct cttggaactc      660

ttgccagagc acgacctccc tgaacacttg aaagccaaga cctgtcggcg ctgtgtggtt      720

attggaagcg gaggaatact gcacggatta gaactgggcc acaccctgaa ccagttcgat      780

gttgtgataa ggttaaacag tgcaccagtt gagggatatt cagaacatgt tggaaataaa      840

actactataa ggatgactta tccagagggc gcaccactgt ctgaccttga atattattcc      900

aatgacttat ttgttgctgt tttatttaag agtgttgatt tcaactggct tcaagcaatg      960

gtaaaaaagg aaaccctgcc attctgggta cgactcttct tttggaagca ggtggcagaa     1020

aaaatcccac tgcagccaaa acatttcagg attttgaatc cagttatcat caaagagact     1080

gcctttgaca tccttcagta ctcagagcct cagtcaaggt tctggggccg agataagaac     1140

gtccccacaa tcggtgtcat tgccgttgtc ttagccacac atctgtgcga tgaagtcagt     1200

ttggcgggtt ttggatatga cctcaatcaa cccagaacac ctttgcacta cttcgacagt     1260

caatgcatgg ctgctatgaa ctttcagacc atgcataatg tgacaacgga aaccaagttc     1320

ctcttaaagc tggtcaaaga gggagtggtg aaagatctca gtggaggcat tgatcgtgaa     1380

ttttgaacac agaaaacctc agttgaaaat gcaactctaa ctctgagagc tgtttttgac     1440

agccttcttg atgtatttct ccatcctgca gatactttga agtgcagctc atgtttttaa     1500

cttttaattt aaaaacacaa aaaaaatttt agctcttccc actttttttt tcctatttat     1560

ttgaggtcag tgtttgtttt tgcacaccat tttgtaaatg aaacttaaga attgaattgg     1620

aaagacttct caaagagaat tgtatgtaac gatgttgtat tgatttttaa gaaagtaatt     1680

taatttgtaa aacttctgct cgtttacact gcacattgaa tacaggtaac taattggaag     1740

gagaggggag gtcactcttt tgatggtggc cctgaacctc attctggttc cctgctgcgc     1800

tgcttggtgt gacccacgga ggatccactc ccaggatgac gtgctccgta gctctgctgc     1860

tgatactggg tctgcgatgc agcggcgtga ggcctgggct ggttggagaa ggtcacaacc     1920

cttctctgtt ggtctgcctt ctgctgaaag actcgagaac caaccaggga agctgtcctg     1980

gaggtccctg gtcggagagg gacatagaat ctgtgacctc tgacaactgt gaagccaccc     2040

tgggctacag aaaccacagt cttcccagca attattacaa ttcttgaatt ccttggggat     2100

tttttactgc cctttcaaag cacttaagtg ttagatctaa cgtgttccag tgtctgtctg     2160

aggtgactta aaaaatcaga acaaaacttc tattatccag agtcatggga gagtacaccc     2220

tttccaggaa taatgttttg ggaaacactg aaatgaaatc ttcccagtat tataaattgt     2280

gtatttaaaa aaaagaaact tttctgaatg cctacctggc ggtgtatacc aggcagtgtg     2340

ccagtttaaa aagatgaaaa agaataaaaa cttttgagga acaaaaaaaa aaaaaaa        2397


<210>  1136
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  1136

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  1137
<211>  3909
<212>  DNA
<213>  Homo Sapiens

<400>  1137
gagcgagagt gtgtcgagtg agtgtgcgtc tgtgtgtccc ggcgagggtg cgcgctcggc       60

gccgggagcg cggccagccg agtccggagg catcgggagg tcgagagccg ccgggacccc      120

agctctgcgt tcactgcccc gtccggagct ggacttcggg gccggggccg gggccgtgcg      180

ccggggacag gcagggccgg gtcgcgggcc gcgcgtcccc caggccggag atctgcgagt      240

gaagagggac gagggaaaag aaacaaagcc acagacgcaa cttgagactc ccgcatccca      300

aaagaagcac cagatcagca aaaaaagaag atgggccccc cgagcctcgt gctgtgcttg      360

ctgtccgcaa ctgtgttctc cctgctgggt ggaagctcgg ccttcctgtc gcaccaccgc      420

ctgaaaggca ggtttcagag ggaccgcagg aacatccgcc ccaacatcat cctggtgctg      480

acggacgacc aggatgtgga gctgggttcc atgcaggtga tgaacaagac ccggcgcatc      540

atggagcagg gcggggcgca cttcatcaac gccttcgtga ccacacccat gtgctgcccc      600

tcacgctcct ccatcctcac tggcaagtac gtccacaacc acaacaccta caccaacaat      660

gagaactgct cctcgccctc ctggcaggca cagcacgaga gccgcacctt tgccgtgtac      720

ctcaatagca ctggctaccg gacagctttc ttcgggaagt atcttaatga atacaacggc      780

tcctacgtgc cacccggctg gaaggagtgg gtcggactcc ttaaaaactc ccgcttttat      840

aactacacgc tgtgtcggaa cggggtgaaa gagaagcacg gctccgacta ctccaaggat      900

tacctcacag acctcatcac caatgacagc gtgagcttct tccgcacgtc caagaagatg      960

tacccgcaca ggccagtcct catggtcatc agccatgcag ccccccacgg ccctgaggat     1020

tcagccccac aatattcacg cctcttccca aacgcatctc agcacatcac gccgagctac     1080

aactacgcgc ccaacccgga caaacactgg atcatgcgct acacggggcc catgaagccc     1140

atccacatgg aattcaccaa catgctccag cggaagcgct tgcagaccct catgtcggtg     1200

gacgactcca tggagacgat ttacaacatg ctggttgaga cgggcgagct ggacaacacg     1260

tacatcgtat acaccgccga ccacggttac cacatcggcc agtttggcct ggtgaaaggg     1320

aaatccatgc catatgagtt tgacatcagg gtcccgttct acgtgagggg ccccaacgtg     1380

gaagccggct gtctgaatcc ccacatcgtc ctcaacattg acctggcccc caccatcctg     1440

gacattgcag gcctggacat acctgcggat atggacggga aatccatcct caagctgctg     1500

gacacggagc ggccggtgaa tcggtttcac ttgaaaaaga agatgagggt ctggcgggac     1560

tccttcttgg tggagagagg caagctgcta cacaagagag acaatgacaa ggtggacgcc     1620

caggaggaga actttctgcc caagtaccag cgtgtgaagg acctgtgtca gcgtgctgag     1680

taccagacgg cgtgtgagca gctgggacag aagtggcagt gtgtggagga cgccacgggg     1740

aagctgaagc tgcataagtg caagggcccc atgcggctgg gcggcagcag agccctctcc     1800

aacctcgtgc ccaagtacta cgggcagggc agcgaggcct gcacctgtga cagcggggac     1860

tacaagctca gcctggccgg acgccggaaa aaactcttca agaagaagta caaggccagc     1920

tatgtccgca gtcgctccat ccgctcagtg gccatcgagg tggacggcag ggtgtaccac     1980

gtaggcctgg gtgatgccgc ccagccccga aacctcacca agcggcactg gccaggggcc     2040

cctgaggacc aagatgacaa ggatggtggg gacttcagtg gcactggagg ccttcccgac     2100

tactcagccg ccaaccccat taaagtgaca catcggtgct acatcctaga gaacgacaca     2160

gtccagtgtg acctggacct gtacaagtcc ctgcaggcct ggaaagacca caagctgcac     2220

atcgaccacg agattgaaac cctgcagaac aaaattaaga acctgaggga agtccgaggt     2280

cacctgaaga aaaagcggcc agaagaatgt gactgtcaca aaatcagcta ccacacccag     2340

cacaaaggcc gcctcaagca cagaggctcc agtctgcatc ctttcaggaa gggcctgcaa     2400

gagaaggaca aggtgtggct gttgcgggag cagaagcgca agaagaaact ccgcaagctg     2460

ctcaagcgcc tgcagaacaa cgacacgtgc agcatgccag gcctcacgtg cttcacccac     2520

gacaaccagc actggcagac ggcgcctttc tggacactgg ggcctttctg tgcctgcacc     2580

agcgccaaca ataacacgta ctggtgcatg aggaccatca atgagactca caatttcctc     2640

ttctgtgaat ttgcaactgg cttcctagag tactttgatc tcaacacaga cccctaccag     2700

ctgatgaatg cagtgaacac actggacagg gatgtcctca accagctaca cgtacagctc     2760

atggagctga ggagctgcaa gggttacaag cagtgtaacc cccggactcg aaacatggac     2820

ctgggactta aagatggagg aagctatgag caatacaggc agtttcagcg tcgaaagtgg     2880

ccagaaatga agagaccttc ttccaaatca ctgggacaac tgtgggaagg ctgggaaggt     2940

taagaaacaa cagaggtgga cctccaaaaa catagaggca tcacctgact gcacaggcaa     3000

tgaaaaacca tgtgggtgat ttccagcaga cctgtggtat tggccaggag gcctgagaaa     3060

gcaagcacgc actctcagtc aacatgacag attctggagg ataaccagca ggagcagaga     3120

taacttcagg aagtccattt ttgcccctgc ttttgctttg gattatacct caccagctgc     3180

acaaaatgca ttttttcgta tcaaaaagtc accactaacc ctcccccaga agctcacaaa     3240

ggaaaacgga gagagcgagc gagagagatt tccttggaaa tttctcccaa gggcgaaagt     3300

cattggaatt tttaaatcat aggggaaaag cagtcctgtt ctaaatcctc ttattctttt     3360

ggtttgtcac aaagaaggaa ctaagaagca ggacagaggc aacgtggaga ggctgaaaac     3420

agtgcagaga cgtttgacaa tgagtcagta gcacaaaaga gatgacattt acctagcact     3480

ataaaccctg gttgcctctg aagaaactgc cttcattgta tatatgtgac tatttacatg     3540

taatcaacat gggaactttt aggggaacct aataagaaat cccaattttc aggagtggtg     3600

gtgtcaataa acgctctgtg gccagtgtaa aagaaaatcc ctcgcagttg tggacatttc     3660

tgttcctgtc cagataccat ttctcctagt atttctttgt tatgtcccag aactgatgtt     3720

ttttttttaa ggtactgaaa agaaatgaag ttgatgtatg tcccaagttt tgatgaaact     3780

gtatttgtaa aaaaaatttt gtagtttaag tattgtcata cagtgttcaa aaccccagcc     3840

aatgaccagc agttggtatg aagaaccttt gacattttgt aaaaggccat ttcttgggaa     3900

aaaaaaaaa                                                             3909


<210>  1138
<211>  870
<212>  PRT
<213>  Homo Sapiens

<400>  1138

Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe 
1               5                   10                  15      


Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys 
            20                  25                  30          


Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu 
        35                  40                  45              


Val Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met 
    50                  55                  60                  


Asn Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn 
65                  70                  75                  80  


Ala Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu 
                85                  90                  95      


Thr Gly Lys Tyr Val His Asn His Asn Thr Tyr Thr Asn Asn Glu Asn 
            100                 105                 110         


Cys Ser Ser Pro Ser Trp Gln Ala Gln His Glu Ser Arg Thr Phe Ala 
        115                 120                 125             


Val Tyr Leu Asn Ser Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr 
    130                 135                 140                 


Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp 
145                 150                 155                 160 


Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg 
                165                 170                 175     


Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu 
            180                 185                 190         


Thr Asp Leu Ile Thr Asn Asp Ser Val Ser Phe Phe Arg Thr Ser Lys 
        195                 200                 205             


Lys Met Tyr Pro His Arg Pro Val Leu Met Val Ile Ser His Ala Ala 
    210                 215                 220                 


Pro His Gly Pro Glu Asp Ser Ala Pro Gln Tyr Ser Arg Leu Phe Pro 
225                 230                 235                 240 


Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Pro 
                245                 250                 255     


Asp Lys His Trp Ile Met Arg Tyr Thr Gly Pro Met Lys Pro Ile His 
            260                 265                 270         


Met Glu Phe Thr Asn Met Leu Gln Arg Lys Arg Leu Gln Thr Leu Met 
        275                 280                 285             


Ser Val Asp Asp Ser Met Glu Thr Ile Tyr Asn Met Leu Val Glu Thr 
    290                 295                 300                 


Gly Glu Leu Asp Asn Thr Tyr Ile Val Tyr Thr Ala Asp His Gly Tyr 
305                 310                 315                 320 


His Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Glu 
                325                 330                 335     


Phe Asp Ile Arg Val Pro Phe Tyr Val Arg Gly Pro Asn Val Glu Ala 
            340                 345                 350         


Gly Cys Leu Asn Pro His Ile Val Leu Asn Ile Asp Leu Ala Pro Thr 
        355                 360                 365             


Ile Leu Asp Ile Ala Gly Leu Asp Ile Pro Ala Asp Met Asp Gly Lys 
    370                 375                 380                 


Ser Ile Leu Lys Leu Leu Asp Thr Glu Arg Pro Val Asn Arg Phe His 
385                 390                 395                 400 


Leu Lys Lys Lys Met Arg Val Trp Arg Asp Ser Phe Leu Val Glu Arg 
                405                 410                 415     


Gly Lys Leu Leu His Lys Arg Asp Asn Asp Lys Val Asp Ala Gln Glu 
            420                 425                 430         


Glu Asn Phe Leu Pro Lys Tyr Gln Arg Val Lys Asp Leu Cys Gln Arg 
        435                 440                 445             


Ala Glu Tyr Gln Thr Ala Cys Glu Gln Leu Gly Gln Lys Trp Gln Cys 
    450                 455                 460                 


Val Glu Asp Ala Thr Gly Lys Leu Lys Leu His Lys Cys Lys Gly Pro 
465                 470                 475                 480 


Met Arg Leu Gly Gly Ser Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr 
                485                 490                 495     


Tyr Gly Gln Gly Ser Glu Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys 
            500                 505                 510         


Leu Ser Leu Ala Gly Arg Arg Lys Lys Leu Phe Lys Lys Lys Tyr Lys 
        515                 520                 525             


Ala Ser Tyr Val Arg Ser Arg Ser Ile Arg Ser Val Ala Ile Glu Val 
    530                 535                 540                 


Asp Gly Arg Val Tyr His Val Gly Leu Gly Asp Ala Ala Gln Pro Arg 
545                 550                 555                 560 


Asn Leu Thr Lys Arg His Trp Pro Gly Ala Pro Glu Asp Gln Asp Asp 
                565                 570                 575     


Lys Asp Gly Gly Asp Phe Ser Gly Thr Gly Gly Leu Pro Asp Tyr Ser 
            580                 585                 590         


Ala Ala Asn Pro Ile Lys Val Thr His Arg Cys Tyr Ile Leu Glu Asn 
        595                 600                 605             


Asp Thr Val Gln Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gln Ala Trp 
    610                 615                 620                 


Lys Asp His Lys Leu His Ile Asp His Glu Ile Glu Thr Leu Gln Asn 
625                 630                 635                 640 


Lys Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg 
                645                 650                 655     


Pro Glu Glu Cys Asp Cys His Lys Ile Ser Tyr His Thr Gln His Lys 
            660                 665                 670         


Gly Arg Leu Lys His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly 
        675                 680                 685             


Leu Gln Glu Lys Asp Lys Val Trp Leu Leu Arg Glu Gln Lys Arg Lys 
    690                 695                 700                 


Lys Lys Leu Arg Lys Leu Leu Lys Arg Leu Gln Asn Asn Asp Thr Cys 
705                 710                 715                 720 


Ser Met Pro Gly Leu Thr Cys Phe Thr His Asp Asn Gln His Trp Gln 
                725                 730                 735     


Thr Ala Pro Phe Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala 
            740                 745                 750         


Asn Asn Asn Thr Tyr Trp Cys Met Arg Thr Ile Asn Glu Thr His Asn 
        755                 760                 765             


Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu 
    770                 775                 780                 


Asn Thr Asp Pro Tyr Gln Leu Met Asn Ala Val Asn Thr Leu Asp Arg 
785                 790                 795                 800 


Asp Val Leu Asn Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys 
                805                 810                 815     


Lys Gly Tyr Lys Gln Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly 
            820                 825                 830         


Leu Lys Asp Gly Gly Ser Tyr Glu Gln Tyr Arg Gln Phe Gln Arg Arg 
        835                 840                 845             


Lys Trp Pro Glu Met Lys Arg Pro Ser Ser Lys Ser Leu Gly Gln Leu 
    850                 855                 860                 


Trp Glu Gly Trp Glu Gly 
865                 870 


<210>  1139
<211>  2935
<212>  DNA
<213>  Homo Sapiens

<400>  1139
atccccgcct cccctcctgc ccaggtgact gactaatccg ccgccttcag gagacagaat       60

tggccaaggc ctgaaggccc cggagtgcac cagcggcatg tacaaagaga ccgtctactc      120

cgccttcaat ctgctcatgc attacccacc cccctcggga gcagggcagc acccccagcc      180

gcagcccccg ctgcacaagg ccaatcagcc cccccacggt gtcccccaac tctctctcta      240

cgaacatttc aacagcccac atcccacccc tgcacctgcg gacatcagcc agaagcaagt      300

tcacaggcct ctgcagaccc ctgacctctc tggcttctac tccctgacct caggcagcat      360

ggggcagctc ccccacactg tgagctggtt cacccaccca tccttgatgc taggttctgg      420

tgtacctggt cacccagcag ccatccccca cccggccatt gtgcccccct cagggaagca      480

ggagctgcag cccttcgacc gcaacctgaa gacacaagca gagtccaagg cagagaagga      540

ggccaagaag ccaaccatca agaagcccct caatgccttc atgctgtaca tgaaggagat      600

gagagccaag gtcattgcag agtgcacact taaggagagc gctgccatca accagatcct      660

gggccgcagg tggcacgcgc tgtcgcgaga agagcaggcc aagtactatg agctggcccg      720

caaggagagg cagctgcaca tgcagctata cccaggctgg tcagcgcggg acaactacgg      780

gaagaagaag aggcggtcga gggaaaagca ccaagaatcc accacagacc ctggctcgcc      840

taagaaatgc cgtgctcgct ttggcctcaa ccagcagacg gattggtgtg gtccgtgcag      900

ataactctct tcactattcc taggaggaaa aagaaatgca ttcggtactt acccggagaa      960

ggccgctgcc ccagccccgt tccttccgat gacagtgctc taggctgccc cgggtcccca     1020

gctccccagg actcaccctc ataccatctg ctgccccgct tccccacaga actgcttact     1080

agccctgcgg agccggcacc tacatcccca ggtctctcca ctgctctcag cctcccaacc     1140

ccagggcccc cacaggcccc ccgcagcacc ctgcagagca cacaggtaca gcaacaggaa     1200

tctcagagac aggtggccta gcaggcacag gacacctggc cgcctccagg agcctacccc     1260

ctgaaagtga cagagaccca gatctcatgg aaactggcca ggggtcctgt taacgtcatc     1320

tcagggtcca gaccctgaag atttcagagg ctgcaggact tctgcctgaa cctggggtca     1380

tcgattcaaa ctgctccaag tggtgggaat cagatctgtc ttgatgtgtc atctaattaa     1440

gggaatccct tgtacctatg gctgcctgca tctattcttt gtaccatctg tcttgccagc     1500

cagaagcctc tgcctcccta gcttttctgc tataggtcag agatgggctg aactgagcct     1560

agctaccttc tctacccatc tcccccatcc cccactgcca caccctcccc attcagacac     1620

ttcatggacc aagaatgagc tggtttgtca aacaacatgt gagcatggtc acaagcacaa     1680

agctcaagat gacagctctt ctaaggaaat ggagaagctc tgtttataaa aacaaaaaca     1740

aaaccagctg ctactcataa gttggaccag aggaagcccc ttactatgat ctcaggagct     1800

tgcaagaagc aggaagggga atggaatagg ttaagtttag gcctatcaac ctaagcaaca     1860

gaaataatct gacactacct tatcaggcaa attggggagg ggagggtgta tctagctcta     1920

gttcaaatta tttggaagtg ttccctgaga aacccaccag cctaagaagc tctggcccca     1980

ggcttgtcac tagcagctgc agtcaacagt tcaaagaagt catggcccaa atccagtgtg     2040

cacccctccc cattcacaga gcctttttca caattccatt tccagttcat ctatggcagt     2100

ccagccagct cctgggcagc ttgagagggc aaacccaaaa cctcatgaca gccagagcct     2160

gtctttcagc attcagtccg cctggccggc tccagtttcc ccatggggct gcgggacaga     2220

ggaccattac aactagatca aggagcccag aaaacctcca gtagtggaca acaggttttc     2280

accatagcct acgttaaccc atttttgagc caagcttcaa ccctcagcct tgaaaaacaa     2340

gtctttaatt taatttttgt tttttgccta aatccaaaga aaaagggctg ccgggccagg     2400

cgcggtggct cacgcctgta atcccagcac tttggcaggc cgaggcaggt ggatcacctg     2460

acgtcagtag tttgagacca gcctggccaa catggtgaaa ccctgtatct actaaaaata     2520

caaaaattag ccggacgtgg tggtgcgcgc atgtaatccc agctactcgg gaggctgagg     2580

cggaagaatc acttgaaccc gggaggcgga ggttccagtg agccgagatg gcgctattgc     2640

actccagtct gggtaacagg gagactgcat ctcaaaaaaa aaaaaaaaaa aaaaaaaggg     2700

ctgtccatgt attcacacac ccctcaaaaa aagcctttag ttcctacttt agccactggt     2760

ttctcagaat ccaaagatca catattctag tgtaacactg caagaagtct tgagaaaaag     2820

attattgtag tgttcaaaat atttttgtat tgttaatgca tcatcataga aaaactttta     2880

aacatgagaa taaagatact ttttactggg tttgtttttc aaagcctgaa aaaaa          2935


<210>  1140
<211>  268
<212>  PRT
<213>  Homo Sapiens

<400>  1140

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15      


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30          


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45              


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60                  


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80  


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95      


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110         


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125             


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140                 


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160 


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175     


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190         


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205             


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220                 


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240 


Ser Thr Thr Asp Pro Gly Ser Pro Lys Lys Cys Arg Ala Arg Phe Gly 
                245                 250                 255     


Leu Asn Gln Gln Thr Asp Trp Cys Gly Pro Cys Arg 
            260                 265             


<210>  1141
<211>  1047
<212>  DNA
<213>  Homo Sapiens

<400>  1141
cccacttctc cagccagcgc cccagccctc ccgccgcccg ctcgcaggtc ccgaggagcg       60

cagactgtgt ccctgacaat gggaacagcc gacagtgatg agatggcccc ggaggcccca      120

cagcacaccc acatcgatgt gcacatccac caggagtctg ccctggccaa gctcctgctc      180

acctgctgct ctgcgctgcg gccccgggcc acccaggcca ggggcagcag ccggctgctg      240

gtggcctcgt gggtgatgca gatcgtgctg gggatcttga gtgcagtcct aggaggattt      300

ttctacatcc gcgactacac cctcctcgtc acctcgggag ctgccatctg gacaggggct      360

gtggctgtgc tggctggagc tgctgccttc atttacgaga aacggggtgg tacatactgg      420

gccctgctga ggactctgct aacgctggca gctttctcca cagccatcgc tgccctcaaa      480

ctttggaatg aagatttccg atatggctac tcttattaca acagtgcctg ccgcatctcc      540

agctcgagtg actggaacac tccagccccc actcagagtc cagaagaagt cagaaggcta      600

cacctatgta cctccttcat ggacatgctg aaggccttgt tcagaaccct tcaggccatg      660

ctcttgggtg tctggattct gctgcttctg gcatctctga cccctctgtg gctgtactgc      720

tggagaatgt tcccaaccaa agggaaaaga gaccagaagg aaatgttgga agtgagtgga      780

atctagccat gcctctcctg attattagtg cctggtgctt ctgcaccggg cgtccctgca      840

tctgactgct ggaagaagaa ccagactgag gaaaagaggc tcttcaacag ccccagttat      900

cctggcccca tgaccgtggc cacagccctg ctccagcagc acttgcccat tccttacacc      960

ccttccccat cctgctccgc ttcatgtccc ctcctgagta gtcatgtgat aataaactct     1020

catgttattg ttcccaggaa aaaaaaa                                         1047


<210>  1142
<211>  235
<212>  PRT
<213>  Homo Sapiens

<400>  1142

Met Gly Thr Ala Asp Ser Asp Glu Met Ala Pro Glu Ala Pro Gln His 
1               5                   10                  15      


Thr His Ile Asp Val His Ile His Gln Glu Ser Ala Leu Ala Lys Leu 
            20                  25                  30          


Leu Leu Thr Cys Cys Ser Ala Leu Arg Pro Arg Ala Thr Gln Ala Arg 
        35                  40                  45              


Gly Ser Ser Arg Leu Leu Val Ala Ser Trp Val Met Gln Ile Val Leu 
    50                  55                  60                  


Gly Ile Leu Ser Ala Val Leu Gly Gly Phe Phe Tyr Ile Arg Asp Tyr 
65                  70                  75                  80  


Thr Leu Leu Val Thr Ser Gly Ala Ala Ile Trp Thr Gly Ala Val Ala 
                85                  90                  95      


Val Leu Ala Gly Ala Ala Ala Phe Ile Tyr Glu Lys Arg Gly Gly Thr 
            100                 105                 110         


Tyr Trp Ala Leu Leu Arg Thr Leu Leu Thr Leu Ala Ala Phe Ser Thr 
        115                 120                 125             


Ala Ile Ala Ala Leu Lys Leu Trp Asn Glu Asp Phe Arg Tyr Gly Tyr 
    130                 135                 140                 


Ser Tyr Tyr Asn Ser Ala Cys Arg Ile Ser Ser Ser Ser Asp Trp Asn 
145                 150                 155                 160 


Thr Pro Ala Pro Thr Gln Ser Pro Glu Glu Val Arg Arg Leu His Leu 
                165                 170                 175     


Cys Thr Ser Phe Met Asp Met Leu Lys Ala Leu Phe Arg Thr Leu Gln 
            180                 185                 190         


Ala Met Leu Leu Gly Val Trp Ile Leu Leu Leu Leu Ala Ser Leu Thr 
        195                 200                 205             


Pro Leu Trp Leu Tyr Cys Trp Arg Met Phe Pro Thr Lys Gly Lys Arg 
    210                 215                 220                 


Asp Gln Lys Glu Met Leu Glu Val Ser Gly Ile 
225                 230                 235 


<210>  1143
<211>  1564
<212>  DNA
<213>  Homo Sapiens

<400>  1143
gaagcacatc tggacagctg tgcggcctcc ttgcgggccg acgtcagccg agcacgtccc       60

ccacgtcctc tccttctcgc cacttattat ttattcgttt tcccaaagaa gcgactaggg      120

acccaagttt aaaaattcct ccccccactc aatgcgagac gtggccagat cccatccaac      180

acacggttta attttcatgg ggctctggga tcaaaagaac agaaacagca acaacaaaag      240

cccagccgct gtctgatttt aagctggcaa agtgggaaaa ataaagtgtt gagtaaacag      300

accaagttgg atcatgggga atttcagagg tcatgccctc cctggaacct tcttttttat      360

tattggtctt tggtggtgta caaagagtat tctgaagtat atctgcaaaa agcaaaagcg      420

aacctgctat cttggttcca aaacattatt ctatcgattg gaaattttgg agggaattac      480

aatagttggc atggctttaa ctggcatggc tggggagcag tttattcctg gagggcccca      540

tctgatgtta tatgactata aacaaggtca ctggaatcaa ctcctgggct ggcatcattt      600

caccatgtat ttcttctttg ggctgttggg tgtggcagat atcttatgtt tcaccatcag      660

ttcacttcct gtgtccttaa ccaagttaat gttgtcaaat gccttatttg tggaggcctt      720

tatcttctac aaccacactc atggccggga aatgctggac atctttgtgc accagctgct      780

ggttttggtc gtctttctga caggcctcgt tgccttccta gagttccttg ttcggaacaa      840

tgtacttctg gagctattgc ggtcaagtct cattctgctt caggggagct ggttctttca      900

gattggattt gtcctgtatc cccccagtgg aggtcctgca tgggatctga tggatcatga      960

aaatattttg tttctcacca tatgcttttg ttggcattat gcagtaacca ttgtcatcgt     1020

tggaatgaat tatgctttca ttacctggtt ggttaaatct agacttaaga ggctctgctc     1080

ctcagaagtt ggacttctga aaaatgctga acgagaacaa gaatcagaag aagaaatgtg     1140

actttgatga gcttccagtt tttctagata aaccttttct tttttacatt gttcttggtt     1200

ttgtttctcg atcttttgtt tggagaacag ctggctaagg atgactctaa gtgtactgtt     1260

tgcatttcca atttggttaa agtatttgaa tttaaatatt ttctttttag ctttgaaaat     1320

attttgggtg atactttcat tttgcacatc atgcacatca tggtattcag gggctagagt     1380

gatttttttc cagattatct aaagttggat gcccacacta tgaaagaaat atttgtttta     1440

tttgccttat agatatgctc aaggttactg ggcttgctac tatttgtaac tccttgacca     1500

tggaattata cttgtttatc ttgttgctgc aatgagaaat aaatgaatgt atgtattttg     1560

gtgc                                                                  1564


<210>  1144
<211>  275
<212>  PRT
<213>  Homo Sapiens

<400>  1144

Met Gly Asn Phe Arg Gly His Ala Leu Pro Gly Thr Phe Phe Phe Ile 
1               5                   10                  15      


Ile Gly Leu Trp Trp Cys Thr Lys Ser Ile Leu Lys Tyr Ile Cys Lys 
            20                  25                  30          


Lys Gln Lys Arg Thr Cys Tyr Leu Gly Ser Lys Thr Leu Phe Tyr Arg 
        35                  40                  45              


Leu Glu Ile Leu Glu Gly Ile Thr Ile Val Gly Met Ala Leu Thr Gly 
    50                  55                  60                  


Met Ala Gly Glu Gln Phe Ile Pro Gly Gly Pro His Leu Met Leu Tyr 
65                  70                  75                  80  


Asp Tyr Lys Gln Gly His Trp Asn Gln Leu Leu Gly Trp His His Phe 
                85                  90                  95      


Thr Met Tyr Phe Phe Phe Gly Leu Leu Gly Val Ala Asp Ile Leu Cys 
            100                 105                 110         


Phe Thr Ile Ser Ser Leu Pro Val Ser Leu Thr Lys Leu Met Leu Ser 
        115                 120                 125             


Asn Ala Leu Phe Val Glu Ala Phe Ile Phe Tyr Asn His Thr His Gly 
    130                 135                 140                 


Arg Glu Met Leu Asp Ile Phe Val His Gln Leu Leu Val Leu Val Val 
145                 150                 155                 160 


Phe Leu Thr Gly Leu Val Ala Phe Leu Glu Phe Leu Val Arg Asn Asn 
                165                 170                 175     


Val Leu Leu Glu Leu Leu Arg Ser Ser Leu Ile Leu Leu Gln Gly Ser 
            180                 185                 190         


Trp Phe Phe Gln Ile Gly Phe Val Leu Tyr Pro Pro Ser Gly Gly Pro 
        195                 200                 205             


Ala Trp Asp Leu Met Asp His Glu Asn Ile Leu Phe Leu Thr Ile Cys 
    210                 215                 220                 


Phe Cys Trp His Tyr Ala Val Thr Ile Val Ile Val Gly Met Asn Tyr 
225                 230                 235                 240 


Ala Phe Ile Thr Trp Leu Val Lys Ser Arg Leu Lys Arg Leu Cys Ser 
                245                 250                 255     


Ser Glu Val Gly Leu Leu Lys Asn Ala Glu Arg Glu Gln Glu Ser Glu 
            260                 265                 270         


Glu Glu Met 
        275 


<210>  1145
<211>  2267
<212>  DNA
<213>  Homo Sapiens

<400>  1145
acttagatga taccagagag caagagagag gaactggggt ttgcgaacct tgtggctttg       60

tctgtttcct gtttcagcaa ggctgctgtg caaaaagaaa gacggtacca agaagggacg      120

tgttaatggg gcccagacct atggattgaa agcgtgtgct ttacccatct gctgtcttgc      180

tccatctgag accagagcca agatctgccc aggactggaa tgctttcccg agtggcttga      240

gttggagcct gggactagga gcagccttat tgaggtacaa ttcatgtgct tgtgggtttg      300

gatggcacaa tctgtgtctg ggctaaggaa agcagacttg gcaccaacat taaccctgac      360

agatccaggc atctattcca ggaactggaa gccaagcgca acaggtgctt ggaggtcatc      420

atgatcagcc cagaccccag gccctcccct ggcttggccc ggtgggctga gagctatgag      480

gccaagtgtg agcgcaggca agagatccgt gaaagccgcc gctgccgtcc caatgtgacc      540

acttgccgcc aggtggggaa gacgctgagg atccaacaga gagagcagct ccagagagct      600

cgactgcagc agttcttcag gaggaggaac ctggagctag aggagaaggg caaagcgcag      660

catccccagg ccagggagca agggccctcc aggcggccag gacaggtgac tgtcctcaag      720

gaacccttgt cttgtgccag aaggatttct tctcccagag agcaggtgac aggcaccagc      780

tctgaagtct ttccagccca gcatcctcct ccctcaggca tctgcaggga tctgtctgac      840

cacctctcct cacaggctgg gggccttcct ccacaggaca ctcccatcaa gaagccaccc      900

aaacaccacc gtggtactca gacaaaggca gaaggaccaa caattaagaa cgatgccagt      960

cagcaaacca attacggagt tgcagttctg gataaggaaa tcatccagct ttctgattac     1020

ctcaaagagg ccctacaaag ggagctggtc ctaaaacaga aaatggtgat tctccaagac     1080

ctactgtcca ctctgattca ggcctctgac agctcttgga agggacagct taatgaagac     1140

aaactgaagg ggaaactgag atccttagaa aaccagctat acacctgtac ccagaaatac     1200

tccccttggg gaatgaaaaa agtactactg gagatggaag accagaaaaa cagctatgag     1260

cagaaggcca aggagtcact gcagaaagtg ctggaggaga aaatgaatgc agagcagcaa     1320

ctacagagca cacagcgatc cctggccctg gcagagcaga agtgtgaaga gtggaggagc     1380

cagtatgagg ctctgaagga ggactggagg acccttggga cccagcacag ggagctggag     1440

agccaactcc acgtgcttca gtccaaactg cagggagcag atagcaggga cttacagatg     1500

aaccaggccc tgcgattttt ggaaaatgag caccagcaac tgcaggccaa gattgaatgc     1560

ctgcaagggg acagagacct gtgcagcttg gatacccagg acctacaaga tcaactaaaa     1620

aggtcagagg cagagaaact caccctggtg accagagtac agcagttgca gggtttgctt     1680

caaaatcaat ccttacagct tcaagaacag gagaaactct taacaaagaa agatcaggct     1740

ttgcccgtgt ggagtccaaa gtccttccct aacgaagtgg agcctgaggg tacagggaag     1800

gagaaagact gggatctcag agaccagctg caaaagaaga ctttgcagct ccaggccaag     1860

gaaaaggagt gcagagaact gcattcagaa ttagacaacc tcagtgacga gtatctctcc     1920

tgcctgcgta agctgcagca ctgtcgagaa gagctgaacc agagccagca gctgcctccc     1980

agaaggcaat gtgggcgatg gctcccagtg ctgatggtgg tgattgctgc agcactggca     2040

gtgttcctgg ccaataaaga caacctgatg atctgaataa tttgtgacaa ctgccttggg     2100

tgaaaatcag aagcaagcaa ctcagcgaaa aactcagaag gtttgggtac attacagctt     2160

gggttttcca actgacttag gatttctgac tttttattaa tttcttaacc tactgtaaat     2220

aaacttcacc tgaccagatt gttcctcaga aaaaaaaaaa aaaaaaa                   2267


<210>  1146
<211>  551
<212>  PRT
<213>  Homo Sapiens

<400>  1146

Met Ile Ser Pro Asp Pro Arg Pro Ser Pro Gly Leu Ala Arg Trp Ala 
1               5                   10                  15      


Glu Ser Tyr Glu Ala Lys Cys Glu Arg Arg Gln Glu Ile Arg Glu Ser 
            20                  25                  30          


Arg Arg Cys Arg Pro Asn Val Thr Thr Cys Arg Gln Val Gly Lys Thr 
        35                  40                  45              


Leu Arg Ile Gln Gln Arg Glu Gln Leu Gln Arg Ala Arg Leu Gln Gln 
    50                  55                  60                  


Phe Phe Arg Arg Arg Asn Leu Glu Leu Glu Glu Lys Gly Lys Ala Gln 
65                  70                  75                  80  


His Pro Gln Ala Arg Glu Gln Gly Pro Ser Arg Arg Pro Gly Gln Val 
                85                  90                  95      


Thr Val Leu Lys Glu Pro Leu Ser Cys Ala Arg Arg Ile Ser Ser Pro 
            100                 105                 110         


Arg Glu Gln Val Thr Gly Thr Ser Ser Glu Val Phe Pro Ala Gln His 
        115                 120                 125             


Pro Pro Pro Ser Gly Ile Cys Arg Asp Leu Ser Asp His Leu Ser Ser 
    130                 135                 140                 


Gln Ala Gly Gly Leu Pro Pro Gln Asp Thr Pro Ile Lys Lys Pro Pro 
145                 150                 155                 160 


Lys His His Arg Gly Thr Gln Thr Lys Ala Glu Gly Pro Thr Ile Lys 
                165                 170                 175     


Asn Asp Ala Ser Gln Gln Thr Asn Tyr Gly Val Ala Val Leu Asp Lys 
            180                 185                 190         


Glu Ile Ile Gln Leu Ser Asp Tyr Leu Lys Glu Ala Leu Gln Arg Glu 
        195                 200                 205             


Leu Val Leu Lys Gln Lys Met Val Ile Leu Gln Asp Leu Leu Ser Thr 
    210                 215                 220                 


Leu Ile Gln Ala Ser Asp Ser Ser Trp Lys Gly Gln Leu Asn Glu Asp 
225                 230                 235                 240 


Lys Leu Lys Gly Lys Leu Arg Ser Leu Glu Asn Gln Leu Tyr Thr Cys 
                245                 250                 255     


Thr Gln Lys Tyr Ser Pro Trp Gly Met Lys Lys Val Leu Leu Glu Met 
            260                 265                 270         


Glu Asp Gln Lys Asn Ser Tyr Glu Gln Lys Ala Lys Glu Ser Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Glu Lys Met Asn Ala Glu Gln Gln Leu Gln Ser Thr 
    290                 295                 300                 


Gln Arg Ser Leu Ala Leu Ala Glu Gln Lys Cys Glu Glu Trp Arg Ser 
305                 310                 315                 320 


Gln Tyr Glu Ala Leu Lys Glu Asp Trp Arg Thr Leu Gly Thr Gln His 
                325                 330                 335     


Arg Glu Leu Glu Ser Gln Leu His Val Leu Gln Ser Lys Leu Gln Gly 
            340                 345                 350         


Ala Asp Ser Arg Asp Leu Gln Met Asn Gln Ala Leu Arg Phe Leu Glu 
        355                 360                 365             


Asn Glu His Gln Gln Leu Gln Ala Lys Ile Glu Cys Leu Gln Gly Asp 
    370                 375                 380                 


Arg Asp Leu Cys Ser Leu Asp Thr Gln Asp Leu Gln Asp Gln Leu Lys 
385                 390                 395                 400 


Arg Ser Glu Ala Glu Lys Leu Thr Leu Val Thr Arg Val Gln Gln Leu 
                405                 410                 415     


Gln Gly Leu Leu Gln Asn Gln Ser Leu Gln Leu Gln Glu Gln Glu Lys 
            420                 425                 430         


Leu Leu Thr Lys Lys Asp Gln Ala Leu Pro Val Trp Ser Pro Lys Ser 
        435                 440                 445             


Phe Pro Asn Glu Val Glu Pro Glu Gly Thr Gly Lys Glu Lys Asp Trp 
    450                 455                 460                 


Asp Leu Arg Asp Gln Leu Gln Lys Lys Thr Leu Gln Leu Gln Ala Lys 
465                 470                 475                 480 


Glu Lys Glu Cys Arg Glu Leu His Ser Glu Leu Asp Asn Leu Ser Asp 
                485                 490                 495     


Glu Tyr Leu Ser Cys Leu Arg Lys Leu Gln His Cys Arg Glu Glu Leu 
            500                 505                 510         


Asn Gln Ser Gln Gln Leu Pro Pro Arg Arg Gln Cys Gly Arg Trp Leu 
        515                 520                 525             


Pro Val Leu Met Val Val Ile Ala Ala Ala Leu Ala Val Phe Leu Ala 
    530                 535                 540                 


Asn Lys Asp Asn Leu Met Ile 
545                 550     


<210>  1147
<211>  1059
<212>  DNA
<213>  Homo Sapiens

<400>  1147
gcagcgcctg acatgcctga tcctctcttt tctgcagttc aagggaaaga cgagatcttg       60

cacaaggcac tctgcttctg cccttggctg gggaagggtg gcatggagcc tctccggctg      120

ctcatcttac tctttgtcac agagctgtcc ggagcccaca acaccacagt gttccagggc      180

gtggcgggcc agtccctgca ggtgtcttgc ccctatgact ccatgaagca ctgggggagg      240

cgcaaggcct ggtgccgcca gctgggagag aagggcccat gccagcgtgt ggtcagcacg      300

cacaacttgt ggctgctgtc cttcctgagg aggtggaatg ggagcacagc catcacagac      360

gataccctgg gtggcactct caccattacg ctgcggaatc tacaacccca tgatgcgggt      420

ctctaccagt gccagagcct ccatggcagt gaggctgaca ccctcaggaa ggtcctggtg      480

gaggtgctgg cagaccccct ggatcaccgg gatgctggag atctctggtt ccccggggag      540

tctgagagct tcgaggatgc ccatgtggag cacagcatct ccaggagcct cttggaagga      600

gaaatcccct tcccacccac ttccatcctt ctcctcctgg cctgcatctt tctcatcaag      660

attctagcag ccagcgccct ctgggctgca gcctggcatg gacagaagcc agggacacat      720

ccacccagtg aactggactg tggccatgac ccagggtatc agctccaaac tctgccaggg      780

ctgagagaca cgtgaaggaa gatgatggga ggaaaagccc aggagaagtc ccaccaggga      840

ccagcccagc ctgcatactt gccacttggc caccaggact ccttgttctg ctctggcaag      900

agactactct gcctgaacac tgcttctcct ggaccctgga agcagggact ggttgaggga      960

gtggggaggt ggtaagaaca cctgacaact tctgaatatt ggacatttta aacacttaca     1020

aataaatcca agactgtcat atttagctgg aaaaaaaaa                            1059


<210>  1148
<211>  230
<212>  PRT
<213>  Homo Sapiens

<400>  1148

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  1149
<211>  2082
<212>  DNA
<213>  Homo Sapiens

<400>  1149
atcactgtag tagtagctgg aaagagaaat ctgtgactcc aattagccag ttcctgcaga       60

ccttgtgagg actagaggaa gaatgctcct ggctgttttg tactgcctgc tgtggagttt      120

ccagacctcc gctggccatt tccctagagc ctgtgtctcc tctaagaacc tgatggagaa      180

ggaatgctgt ccaccgtgga gcggggacag gagtccctgt ggccagcttt caggcagagg      240

ttcctgtcag aatatccttc tgtccaatgc accacttggg cctcaatttc ccttcacagg      300

ggtggatgac cgggagtcgt ggccttccgt cttttataat aggacctgcc agtgctctgg      360

caacttcatg ggattcaact gtggaaactg caagtttggc ttttggggac caaactgcac      420

agagagacga ctcttggtga gaagaaacat cttcgatttg agtgccccag agaaggacaa      480

attttttgcc tacctcactt tagcaaagca taccatcagc tcagactatg tcatccccat      540

agggacctat ggccaaatga aaaatggatc aacacccatg tttaacgaca tcaatattta      600

tgacctcttt gtctggatgc attattatgt gtcaatggat gcactgcttg ggggatctga      660

aatctggaga gacattgatt ttgcccatga agcaccagct tttctgcctt ggcatagact      720

cttcttgttg cggtgggaac aagaaatcca gaagctgaca ggagatgaaa acttcactat      780

tccatattgg gactggcggg atgcagaaaa gtgtgacatt tgcacagatg agtacatggg      840

aggtcagcac cccacaaatc ctaacttact cagcccagca tcattcttct cctcttggca      900

gattgtctgt agccgattgg aggagtacaa cagccatcag tctttatgca atggaacgcc      960

cgagggacct ttacggcgta atcctggaaa ccatgacaaa tccagaaccc caaggctccc     1020

ctcttcagct gatgtagaat tttgcctgag tttgacccaa tatgaatctg gttccatgga     1080

taaagctgcc aatttcagct ttagaaatac actggaagga tttgctagtc cacttactgg     1140

gatagcggat gcctctcaaa gcagcatgca caatgccttg cacatctata tgaatggaac     1200

aatgtcccag gtacagggat ctgccaacga tcctatcttc cttcttcacc atgcatttgt     1260

tgacagtatt tttgagcagt ggctccgaag gcaccgtcct cttcaagaag tttatccaga     1320

agccaatgca cccattggac ataaccggga atcctacatg gttcctttta taccactgta     1380

cagaaatggt gatttcttta tttcatccaa agatctgggc tatgactata gctatctaca     1440

agattcagac ccagactctt ttcaagacta cattaagtcc tatttggaac aagcgagtcg     1500

gatctggtca tggctccttg gggcggcgat ggtaggggcc gtcctcactg ccctgctggc     1560

agggcttgtg agcttgctgt gtcgtcacaa gagaaagcag cttcctgaag aaaagcagcc     1620

actcctcatg gagaaagagg attaccacag cttgtatcag agccatttat aaaaggctta     1680

ggcaatagag tagggccaaa aagcctgacc tcactctaac tcaaagtaat gtccaggttc     1740

ccagagaata tctgctggta tttttctgta aagaccattt gcaaaattgt aacctaatac     1800

aaagtgtagc cttcttccaa ctcaggtaga acacacctgt ctttgtcttg ctgttttcac     1860

tcagcccttt taacattttc ccctaagccc atatgtctaa ggaaaggatg ctatttggta     1920

atgaggaact gttatttgta tgtgaattaa agtgctctta ttttaaaaaa ttgaaataat     1980

tttgattttt gccttctgat tatttaaaga tctatatatg ttttattggc cccttcttta     2040

ttttaataaa acagtgagaa atctaaaaaa aaaaaaaaaa aa                        2082


<210>  1150
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  1150

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  1151
<211>  2556
<212>  DNA
<213>  Homo Sapiens

<400>  1151
agcctcagcc ttgcctctcc ccctcttgct ttatctcctc atttctgtgt gcaggcgagc       60

ttcttggcct aagggcagga agagatggca gcgggggaga cgcagctcta cgccaaggtc      120

tccaacaagc tcaagagccg cagcagcccc tcgctcctgg agcccctcct ggccatgggc      180

ttcccggtgc acaccgcgct gaaagcgttg gcagccacgg ggaggaagac ggcggaggag      240

gccttggcct ggctgcatga tcattgcaat gacccttccc tagacgaccc catcccccag      300

gagtatgccc ttttcctctg tccaacgggg cccctgctgg aaaaacttca agagttctgg      360

agagagagca agcgccagtg tgcaaagaac agagctcatg aggtcttccc acacgtgaca      420

ctctgtgact tcttcacgtg tgaagaccag aaggtggaat gcctgtacga ggcgctgaag      480

agagctggag acaggctcct gggctccttc cccacggccg tgcctctggc tctccactcc      540

tccatcagct acctcggctt cttcgtcagt ggcagccccg cagacgtcat ccgggaattc      600

gccatgacct tcgccacgga agcatctctc ttagcaggca cttccgtttc ccgcttctgg      660

attttcagcc aggtgcctgg acatggccct aacctgaggc tgagcaattt aactagagcc      720

tccttcgtga gccactacat ccttcaaaaa tactgctccg tgaagccttg caccaaacag      780

ctgcatctga ccttggccca caagttctac ccccaccacc agaggacgct ggagcagctg      840

gccagagcca tccccctggg ccacagctgc cagtggaccg cagcactcta ctcccgagac      900

atgcgctttg tgcactacca gaccctgaga gccctattcc agtacaaacc ccagaacgtg      960

gatgagctga cgctaagtcc tggtgactac atctttgtgg accccacgca gcaggacgaa     1020

gccagcgagg gctgggtgat tgggatctca cagcggacgg gctgccgggg cttcctgccg     1080

gaaaactaca cggatcgagc cagtgagtct gacacgtggg tgaagcacag gatgtacacc     1140

ttcagtctag ccacagacct gaactccaga aaggatggtg aagccagcag cagatgcagc     1200

ggggaatttc ttccacaaac ggcaaggagt cttagcagct tacaggcctt gcaggctacc     1260

gttgcaagga agagcgtgct ggtggttcgc cacggggaga gagtggatca gatcttcggg     1320

aaggcatggc tgcagcaatg ctccactcct gatgggaaat actacaggcc agacctgaat     1380

ttcccctgca gtctgccaag acggagtcgt gggatcaaag actttgaaaa cgatccccca     1440

ttatcatcgt gtggcatttt ccagtccaga attgcagggg acgcgctact ggacagtggt     1500

atcagaatca gctctgtgtt tgcctcccca gccctccgct gtgtgcagac ggccaaactc     1560

atcctggaag aactcaaact ggagaaaaaa atcaagatac gagtggaacc tggaatcttt     1620

gaatggacaa aatgggaagc tggcaaaacc accccaaccc tcatgagcct ggaagagctg     1680

aaagaggcaa atttcaacat tgacactgat tacaggcccg cgtttcccct gtccgccctc     1740

atgccggccg agagctacca ggagtacatg gacaggtgca cggcgagcat ggtgcaaatc     1800

gtcaacacct gtccacagga cacgggtgtc atcctaattg tgagtcacgg ctccactctg     1860

gactcctgca cgcggccact gctcgggctg ccgccccggg aatgtgggga ttttgcccaa     1920

ctcgtgagaa agatcccttc cctgggcatg tgcttctgtg aagaaaataa agaggaagga     1980

aaatgggagt tggtgaaccc accggtgaag accctgaccc acggggcgaa cgcagcattt     2040

aactggagga actggatctc aggcaactga gagccacggt gatgttgtca taacctcaga     2100

gtggagaggc agaaaccatg tgcagaggct gggagatgct gctgtttcca gaggcgtctt     2160

agtctcaccc aatgtgattt gtagaagcac gagacgcact tttatatccc ggaatatttc     2220

cctccggctt tcgcctttgt aactcccatc tgtggaccca tcgtccacca gcccagctgc     2280

ggggagcaca gggcaggtgg ctgggtgagg atgccgccct gcagcatgta caccgagtgt     2340

ctgcagctgg ggacacaact gcccgggact ctaacttcca ggaattaaag actcaccaca     2400

cacgaaggat ctaaccactt cattttccat ggtctaatca ttaaattccc aatcgttttt     2460

tctttttctg ggtccatcac tctttagcca tatccacatg ggctaaaaca ggtgtaatag     2520

tcaataaaat ggtcccagaa aaccatcgac caggtc                               2556


<210>  1152
<211>  661
<212>  PRT
<213>  Homo Sapiens

<400>  1152

Met Ala Ala Gly Glu Thr Gln Leu Tyr Ala Lys Val Ser Asn Lys Leu 
1               5                   10                  15      


Lys Ser Arg Ser Ser Pro Ser Leu Leu Glu Pro Leu Leu Ala Met Gly 
            20                  25                  30          


Phe Pro Val His Thr Ala Leu Lys Ala Leu Ala Ala Thr Gly Arg Lys 
        35                  40                  45              


Thr Ala Glu Glu Ala Leu Ala Trp Leu His Asp His Cys Asn Asp Pro 
    50                  55                  60                  


Ser Leu Asp Asp Pro Ile Pro Gln Glu Tyr Ala Leu Phe Leu Cys Pro 
65                  70                  75                  80  


Thr Gly Pro Leu Leu Glu Lys Leu Gln Glu Phe Trp Arg Glu Ser Lys 
                85                  90                  95      


Arg Gln Cys Ala Lys Asn Arg Ala His Glu Val Phe Pro His Val Thr 
            100                 105                 110         


Leu Cys Asp Phe Phe Thr Cys Glu Asp Gln Lys Val Glu Cys Leu Tyr 
        115                 120                 125             


Glu Ala Leu Lys Arg Ala Gly Asp Arg Leu Leu Gly Ser Phe Pro Thr 
    130                 135                 140                 


Ala Val Pro Leu Ala Leu His Ser Ser Ile Ser Tyr Leu Gly Phe Phe 
145                 150                 155                 160 


Val Ser Gly Ser Pro Ala Asp Val Ile Arg Glu Phe Ala Met Thr Phe 
                165                 170                 175     


Ala Thr Glu Ala Ser Leu Leu Ala Gly Thr Ser Val Ser Arg Phe Trp 
            180                 185                 190         


Ile Phe Ser Gln Val Pro Gly His Gly Pro Asn Leu Arg Leu Ser Asn 
        195                 200                 205             


Leu Thr Arg Ala Ser Phe Val Ser His Tyr Ile Leu Gln Lys Tyr Cys 
    210                 215                 220                 


Ser Val Lys Pro Cys Thr Lys Gln Leu His Leu Thr Leu Ala His Lys 
225                 230                 235                 240 


Phe Tyr Pro His His Gln Arg Thr Leu Glu Gln Leu Ala Arg Ala Ile 
                245                 250                 255     


Pro Leu Gly His Ser Cys Gln Trp Thr Ala Ala Leu Tyr Ser Arg Asp 
            260                 265                 270         


Met Arg Phe Val His Tyr Gln Thr Leu Arg Ala Leu Phe Gln Tyr Lys 
        275                 280                 285             


Pro Gln Asn Val Asp Glu Leu Thr Leu Ser Pro Gly Asp Tyr Ile Phe 
    290                 295                 300                 


Val Asp Pro Thr Gln Gln Asp Glu Ala Ser Glu Gly Trp Val Ile Gly 
305                 310                 315                 320 


Ile Ser Gln Arg Thr Gly Cys Arg Gly Phe Leu Pro Glu Asn Tyr Thr 
                325                 330                 335     


Asp Arg Ala Ser Glu Ser Asp Thr Trp Val Lys His Arg Met Tyr Thr 
            340                 345                 350         


Phe Ser Leu Ala Thr Asp Leu Asn Ser Arg Lys Asp Gly Glu Ala Ser 
        355                 360                 365             


Ser Arg Cys Ser Gly Glu Phe Leu Pro Gln Thr Ala Arg Ser Leu Ser 
    370                 375                 380                 


Ser Leu Gln Ala Leu Gln Ala Thr Val Ala Arg Lys Ser Val Leu Val 
385                 390                 395                 400 


Val Arg His Gly Glu Arg Val Asp Gln Ile Phe Gly Lys Ala Trp Leu 
                405                 410                 415     


Gln Gln Cys Ser Thr Pro Asp Gly Lys Tyr Tyr Arg Pro Asp Leu Asn 
            420                 425                 430         


Phe Pro Cys Ser Leu Pro Arg Arg Ser Arg Gly Ile Lys Asp Phe Glu 
        435                 440                 445             


Asn Asp Pro Pro Leu Ser Ser Cys Gly Ile Phe Gln Ser Arg Ile Ala 
    450                 455                 460                 


Gly Asp Ala Leu Leu Asp Ser Gly Ile Arg Ile Ser Ser Val Phe Ala 
465                 470                 475                 480 


Ser Pro Ala Leu Arg Cys Val Gln Thr Ala Lys Leu Ile Leu Glu Glu 
                485                 490                 495     


Leu Lys Leu Glu Lys Lys Ile Lys Ile Arg Val Glu Pro Gly Ile Phe 
            500                 505                 510         


Glu Trp Thr Lys Trp Glu Ala Gly Lys Thr Thr Pro Thr Leu Met Ser 
        515                 520                 525             


Leu Glu Glu Leu Lys Glu Ala Asn Phe Asn Ile Asp Thr Asp Tyr Arg 
    530                 535                 540                 


Pro Ala Phe Pro Leu Ser Ala Leu Met Pro Ala Glu Ser Tyr Gln Glu 
545                 550                 555                 560 


Tyr Met Asp Arg Cys Thr Ala Ser Met Val Gln Ile Val Asn Thr Cys 
                565                 570                 575     


Pro Gln Asp Thr Gly Val Ile Leu Ile Val Ser His Gly Ser Thr Leu 
            580                 585                 590         


Asp Ser Cys Thr Arg Pro Leu Leu Gly Leu Pro Pro Arg Glu Cys Gly 
        595                 600                 605             


Asp Phe Ala Gln Leu Val Arg Lys Ile Pro Ser Leu Gly Met Cys Phe 
    610                 615                 620                 


Cys Glu Glu Asn Lys Glu Glu Gly Lys Trp Glu Leu Val Asn Pro Pro 
625                 630                 635                 640 


Val Lys Thr Leu Thr His Gly Ala Asn Ala Ala Phe Asn Trp Arg Asn 
                645                 650                 655     


Trp Ile Ser Gly Asn 
            660     


<210>  1153
<211>  4263
<212>  DNA
<213>  Homo Sapiens

<400>  1153
aggaaacggt ttattaggag ggagtggtgg agctgggcca ggcaggaaga cgctggaata       60

agaaacattt ttgctccagc ccccatccca gtcccgggag gctgccgcgc cagctgcgcc      120

gagcgagccc ctccccggct ccagcccggt ccggggccgc gcccggaccc cagcccgccg      180

tccagcgctg gcggtgcaac tgcggccgcg cggtggaggg gaggtggccc cggtccgccg      240

aaggctagcg ccccgccacc cgcagagcgg gcccagaggg accatgacct tgggctcccc      300

caggaaaggc cttctgatgc tgctgatggc cttggtgacc cagggagacc ctgtgaagcc      360

gtctcggggc ccgctggtga cctgcacgtg tgagagccca cattgcaagg ggcctacctg      420

ccggggggcc tggtgcacag tagtgctggt gcgggaggag gggaggcacc cccaggaaca      480

tcggggctgc gggaacttgc acagggagct ctgcaggggg cgccccaccg agttcgtcaa      540

ccactactgc tgcgacagcc acctctgcaa ccacaacgtg tccctggtgc tggaggccac      600

ccaacctcct tcggagcagc cgggaacaga tggccagctg gccctgatcc tgggccccgt      660

gctggccttg ctggccctgg tggccctggg tgtcctgggc ctgtggcatg tccgacggag      720

gcaggagaag cagcgtggcc tgcacagcga gctgggagag tccagtctca tcctgaaagc      780

atctgagcag ggcgacagca tgttggggga cctcctggac agtgactgca ccacagggag      840

tggctcaggg ctccccttcc tggtgcagag gacagtggca cggcaggttg ccttggtgga      900

gtgtgtggga aaaggccgct atggcgaagt gtggcggggc ttgtggcacg gtgagagtgt      960

ggccgtcaag atcttctcct cgagggatga acagtcctgg ttccgggaga ctgagatcta     1020

taacacagtg ttgctcagac acgacaacat cctaggcttc atcgcctcag acatgacctc     1080

ccgcaactcg agcacgcagc tgtggctcat cacgcactac cacgagcacg gctccctcta     1140

cgactttctg cagagacaga cgctggagcc ccatctggct ctgaggctag ctgtgtccgc     1200

ggcatgcggc ctggcgcacc tgcacgtgga gatcttcggt acacagggca aaccagccat     1260

tgcccaccgc gacttcaaga gccgcaatgt gctggtcaag agcaacctgc agtgttgcat     1320

cgccgacctg ggcctggctg tgatgcactc acagggcagc gattacctgg acatcggcaa     1380

caacccgaga gtgggcacca agcggtacat ggcacccgag gtgctggacg agcagatccg     1440

cacggactgc tttgagtcct acaagtggac tgacatctgg gcctttggcc tggtgctgtg     1500

ggagattgcc cgccggacca tcgtgaatgg catcgtggag gactatagac cacccttcta     1560

tgatgtggtg cccaatgacc ccagctttga ggacatgaag aaggtggtgt gtgtggatca     1620

gcagaccccc accatcccta accggctggc tgcagacccg gtcctctcag gcctagctca     1680

gatgatgcgg gagtgctggt acccaaaccc ctctgcccga ctcaccgcgc tgcggatcaa     1740

gaagacacta caaaaaatta gcaacagtcc agagaagcct aaagtgattc aatagcccag     1800

gagcacctga ttcctttctg cctgcagggg gctggggggg tggggggcag tggatggtgc     1860

cctatctggg tagaggtagt gtgagtgtgg tgtgtgctgg ggatgggcag ctgcgcctgc     1920

ctgctcggcc cccagcccac ccagccaaaa atacagctgg gctgaaacct gatcccctgc     1980

tgtctggcct gctcaaagcg gcaggctccc tgacgcctgg ctctctcccc acccctatgg     2040

ccagcatggt gcacccccta ccactcccgg gacaggatgc aaaagaggct ccagagtcag     2100

agtgccaagc cagggaatcc cagtcccaga ctcagagccc gggcctgcac tttgccccct     2160

gcccttgatc aaccccactg ccccaccaga gctgccaggg tggcacaggg ccctgtccag     2220

cccctggcac acacttccct gccaggcctc agcctctagc ataagctcca gagagccagg     2280

gcccatcagt ttctctctgt ggatttgtat ctcagctcca tgatgccttg ggctttctgt     2340

ctcctcaaca agagtgcagc ttgctgaatg tcagctgcct gagagagctg gggcctgact     2400

tactagggca ttaaatccta agaggtccta ctgaggtgtg gcaggatcac aggccagtgg     2460

aaaaagggca ggtcagatgg gcaaggccca ggactttcag attaactgag aggatatcga     2520

ggccaagcat ggcaggggga aggtcagtgg gtgtcaagag acccaggtct gaccccggat     2580

gtttgctcca tgtgacaaaa gcaggcctgt ctcaggacct tttcttttct tttttccttc     2640

tttttttttt tgacacggag tttcgctctt gttgtccagg ctagagtgca atggcatgat     2700

cccagctcac cgcaacgtct acctcccagg ttcaaatcat tctcttgcct cagactcccg     2760

agtagctggg attacaggca catgccacca tgcctggcta attttgtata tttagtagaa     2820

acagggtttc accatgctgg ccatgctggt ctcgaactcc tgacctcagg tgttccacct     2880

acctcagcct cccaaagtgc tggggttaca ggtgtgagcc atcgcgcctg gccaggacct     2940

ttgtttctta tctacatatt ggaagatttg gtcctgatgt cctttgaggc ttctttagct     3000

ctagttctct gacacttcag cctatatcac agctaacttc ttcagtctca tctattcctt     3060

atgctccagc ccctggcaat ttgcctcaag atgggggttt gaaaataact ttacctgact     3120

caaggagtgt ctggagcacc tcctagtcta agtctgcaag ctccagttct tgcctaaaac     3180

catgccagtg gccacccttg ggctcagaca gctctgggcc ttttgaccac aagccagccc     3240

ctcgccctct ctgtggcata gtcttctctg ccccaggact gcagggcggc ttcctccaag     3300

gcttccaagg ctcaaaagaa atttggctcc atccaagaag gctccagctc ccctactggc     3360

ccctggctca ggcccacacc cctggccagg cccagagagt gtgtctcagg agaattcaat     3420

ggctctagag agacacacag aaagtttggc atttggaaat ttcaaggatg tatgtatgct     3480

cacgtatgga gcaggttgtc ctggtccctg ggtgcaggga agtgggctgc agggaagtgg     3540

attggagggg agcttgagga atataaggag cgggggtgga gactcaggct atggacaagg     3600

acagccccaa ggttgggaag acctggcctt agtcgtcctc agcctagggg cagggcagtg     3660

aagaaagctc tccccgctcc tgctgtaatg acccagagta gcctccccag gccggcatct     3720

tatgtgtgtc ttccaccatc ctcatggtgg cacttttcta ggcctgtctc ccagcattgt     3780

gcaaggctcg gaagagaacc aggaagtgaa actgggtgaa aacagaaagc tcaatggatg     3840

ggctaggttc ccagatcatt agggcagagt ttgcacgtcc tctggtcact ggaatccacc     3900

cagcccacga atcatctccc tcttgaagga ttttatttct actgggtttt ggaacaaact     3960

cctgctgaga ccccacagcc agaaactgaa agcagcagct ccccaaagcc tggaaaatcc     4020

ctaagagaag gcctggggca ggaagtggag tgacagggga caggtagaga gaagggggcc     4080

caatggccag ggagtgaagg aggtggcgtt gctgagagca gtctgcacat gcttctgtct     4140

gagtgcagga aggtgttcca gggtcgaaat tacacttctc gtacctggag acgctgtttg     4200

tgggagcact gggctcatgc ctggcacaca ataggtctgc aataaaccat ggttaaatcc     4260

tga                                                                   4263


<210>  1154
<211>  503
<212>  PRT
<213>  Homo Sapiens

<400>  1154

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  1155
<211>  2165
<212>  DNA
<213>  Homo Sapiens

<400>  1155
ttggccctgg gggcggggcg aggcgcagag gtgcgtcctg agggcggggc ggtgacgcaa       60

gagcgactcc tgggggcggg gcgaggcctt ggagatgcgt ccggaggcgg tggggagcga      120

agactgaccc ggggccgtga cgcgggggca ggccctgggg cgggggcggg tcctggggac      180

tggggcgggc ggccgaggcc cggaagcgga ctgaggcggc ctggagtctt agttggctac      240

tcgccatgga cgaagcggat cggcggctcc tgcggcggtg ccggctgcgg ctggtggaag      300

agctgcaggt ggaccagctc tgggacgccc tgctgagccg cgagctgttc aggccccata      360

tgatcgagga catccagcgg gcaggctctg gatctcggcg ggatcaggcc aggcagctga      420

tcatagatct ggagactcga gggagtcagg ctcttccttt gttcatctcc tgcttagagg      480

acacaggcca ggacatgctg gcttcgtttc tgcgaactaa caggcaagca gcaaagttgt      540

cgaagccaac cctagaaaac cttaccccag tggtgctcag accagagatt cgcaaaccag      600

aggttctcag accggaaaca cccagaccag tggacattgg ttctggagga tttggtgatg      660

tcggtgctct tgagagtttg aggggaaatg cagatttggc ttacatcctg agcatggagc      720

cctgtggcca ctgcctcatt atcaacaatg tgaacttctg ccgtgagtcc gggctccgca      780

cccgcactgg ctccaacatc gactgtgaga agttgcggcg tcgcttctcc tcgctgcatt      840

tcatggtgga ggtgaagggc gacctgactg ccaagaaaat ggtgctggct ttgctggagc      900

tggcgcagca ggaccacggt gctctggact gctgcgtggt ggtcattctc tctcacggct      960

gtcaggccag ccacctgcag ttcccagggg ctgtctacgg cacagatgga tgccctgtgt     1020

cggtcgagaa gattgtgaac atcttcaatg ggaccagctg ccccagcctg ggagggaagc     1080

ccaagctctt tttcatccag gcctgtggtg gggagcagaa agaccatggg tttgaggtgg     1140

cctccacttc ccctgaagac gagtcccctg gcagtaaccc cgagccagat gccaccccgt     1200

tccaggaagg tttgaggacc ttcgaccagc tggacgccat atctagtttg cccacaccca     1260

gtgacatctt tgtgtcctac tctactttcc caggttttgt ttcctggagg gaccccaaga     1320

gtggctcctg gtacgttgag accctggacg acatctttga gcagtgggct cactctgaag     1380

acctgcagtc cctcctgctt agggtcgcta atgctgtttc ggtgaaaggg atttataaac     1440

agatgcctgg ttgctttaat ttcctccgga aaaaactttt ctttaaaaca tcataaggcc     1500

agggcccctc accctgcctt atcttgcacc ccaaagcttt cctgccccag gcctgaaaga     1560

ggctgaggcc tggactttcc tgcaactcaa ggactttgca gccggcacag ggtctgctct     1620

ttctctgcca gtgacagaca ggctcttagc agcttccaga ttgacgacaa gtgctgaaca     1680

gtggaggaag agggacagat gaatgccgtg gattgcacgt ggcctcttga gcagtggctg     1740

gtccagggct agtgacttgt gtcccatgat ccctgtgttg tctctagagc agggattaac     1800

ctctgcacta ctgacatgtg gggccaggtc accctttgct gtgaggctgt cctgtacatt     1860

gtgggatgtt cagcactgtc ccttgcctca atgccagtaa cgcgtcttcc tgagtggtgc     1920

caaacaaaaa ggttctcagg tgttgccaaa tatgtcctgg ggtataaaac tttcctcgcc     1980

tgacaaccac tggtctgtag ggatttttgg ctacacacaa accagtatcg ctcatagatc     2040

agcaaaccgg ggcctactag agtctgaaca gctgtaatct atgaattcta agtgaaattt     2100

taaaaattgt taatttttcc tatattgcat taattttaaa aaataaatct gaggcaaata     2160

tggac                                                                 2165


<210>  1156
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  1156

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 
    290                 295                 300                 


Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 
305                 310                 315                 320 


Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 
                325                 330                 335     


Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 
            340                 345                 350         


Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 
        355                 360                 365             


Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 
    370                 375                 380                 


Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 
385                 390                 395                 400 


Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
                405                 410                 415     


<210>  1157
<211>  2992
<212>  DNA
<213>  Homo Sapiens

<400>  1157
aactgagcga ggagcaattg attaatagct cggcgagggg actcactgac tgttataata       60

acactacacc agcaactcct ggcttcccag cagccggaac acagacagga gagagtcagt      120

ggcaaataga catttttctt atttcttaaa aaacagcaac ttgtttgcta cttttatttc      180

tgttgatttt tttttcttgg tgtgtgtggt ggttgttttt aagtgtggag ggcaaaagga      240

gataccatcc caggctcagt ccaacccctc tccaaaacgg cttttctgac actccaggta      300

gcgagggagt tgggtctcca ggttgtgcga ggagcaaatg atgaccgcca aggccgtaga      360

caaaatccca gtaactctca gtggttttgt gcaccagctg tctgacaaca tctacccggt      420

ggaggacctc gccgccacgt cggtgaccat ctttcccaat gccgaactgg gaggcccctt      480

tgaccagatg aacggagtgg ccggagatgg catgatcaac attgacatga ctggagagaa      540

gaggtcgttg gatctcccat atcccagcag ctttgctccc gtctctgcac ctagaaacca      600

gaccttcact tacatgggca agttctccat tgaccctcag taccctggtg ccagctgcta      660

cccagaaggc ataatcaata ttgtgagtgc aggcatcttg caaggggtca cttccccagc      720

ttcaaccaca gcctcatcca gcgtcacctc tgcctccccc aacccactgg ccacaggacc      780

cctgggtgtg tgcaccatgt cccagaccca gcctgacctg gaccacctgt actctccgcc      840

accgcctcct cctccttatt ctggctgtgc aggagacctc taccaggacc cttctgcgtt      900

cctgtcagca gccaccacct ccacctcttc ctctctggcc tacccaccac ctccttccta      960

tccatccccc aagccagcca cggacccagg tctcttccca atgatcccag actatcctgg     1020

attctttcca tctcagtgcc agagagacct acatggtaca gctggcccag accgtaagcc     1080

ctttccctgc ccactggaca ccctgcgggt gccccctcca ctcactccac tctctacaat     1140

ccgtaacttt accctggggg gccccagtgc tggggtgacc ggaccagggg ccagtggagg     1200

cagcgaggga ccccggctgc ctggtagcag ctcagcagca gcagcagccg ccgccgccgc     1260

cgcctataac ccacaccacc tgccactgcg gcccattctg aggcctcgca agtaccccaa     1320

cagacccagc aagacgccgg tgcacgagag gccctacccg tgcccagcag aaggctgcga     1380

ccggcggttc tcccgctctg acgagctgac acggcacatc cgaatccaca ctgggcataa     1440

gcccttccag tgtcggatct gcatgcgcaa cttcagccgc agtgaccacc tcaccaccca     1500

tatccgcacc cacaccggtg agaagccctt cgcctgtgac tactgtggcc gaaagtttgc     1560

ccggagtgat gagaggaagc gccacaccaa gatccacctg agacagaaag agcggaaaag     1620

cagtgccccc tctgcatcgg tgccagcccc ctctacagcc tcctgctctg ggggcgtgca     1680

gcctgggggt accctgtgca gcagtaacag cagcagtctt ggcggagggc cgctcgcccc     1740

ttgctcctct cggacccgga caccttgaga tgagactcag gctgatacac cagctcccaa     1800

aggtcccgga ggccctttgt ccactggagc tgcacaacaa acactaccac cctttcctgt     1860

ccctctctcc ctttgttggg caaagggctt tggtggagct agcactgccc cctttccacc     1920

tagaagcagg ttcttcctaa aacttagccc attctagtct ctcttaggtg agttgactat     1980

caacccaagg caaaggggag gctcagaagg aggtggtgtg gggacccctg gccaagaggg     2040

ctgaggtctg accctgcttt aaagggttgt ttgactaggt tttgctaccc cacttcccct     2100

tattttgacc catcacaggt ttttgaccct ggatgtcaga gttgatctaa gacgttttct     2160

acaataggtt gggagatgct gatcccttca agtggggaca gcaaaaagac aagcaaaact     2220

gatgtgcact ttatggcttg ggactgattt gggggacatt gtacagtgag tgaagtatag     2280

cctttatgcc acactctgtg gccctaaaat ggtgaatcag agcatatcta gttgtctcaa     2340

cccttgaagc aatatgtatt ataaactcag agaacagaag tgcaatgtga tgggaggaac     2400

atagcaatat ctgctccttt tcgagttgtt tgagaaatgt aggctatttt ttcagtgtat     2460

atccactcag attttgtgta tttttgatgt acactgttct ctaaattctg aatctttggg     2520

aaaaaatgta aagcatttat gatctcagag gttaacttat ttaaggggga tgtacatata     2580

ttctctgaaa ctaggatgca tgcaattgtg ttggaagtgt ccttggtgcc ttgtgtgatg     2640

tagacaatgt tacaaggtct gcatgtaaat gggttgcctt attatggaga aaaaaatcac     2700

tccctgagtt tagtatggct gtatatttct gcctattaat atttggaatt ttttttagaa     2760

agtatatttt tgtatgcttt gttttgtgac ttaaaagtgt tacctttgta gtcaaatttc     2820

agataagaat gtacataatg ttaccggagc tgatttgttt ggtcattagc tcttaatagt     2880

tgtgaaaaaa taaatctatt ctaacgcaaa accactaact gaagttcaga taatggatgg     2940

tttgtgacta tagtgtaaat aaatactttt caacaataaa aaaaaaaaaa aa             2992


<210>  1158
<211>  476
<212>  PRT
<213>  Homo Sapiens

<400>  1158

Met Met Thr Ala Lys Ala Val Asp Lys Ile Pro Val Thr Leu Ser Gly 
1               5                   10                  15      


Phe Val His Gln Leu Ser Asp Asn Ile Tyr Pro Val Glu Asp Leu Ala 
            20                  25                  30          


Ala Thr Ser Val Thr Ile Phe Pro Asn Ala Glu Leu Gly Gly Pro Phe 
        35                  40                  45              


Asp Gln Met Asn Gly Val Ala Gly Asp Gly Met Ile Asn Ile Asp Met 
    50                  55                  60                  


Thr Gly Glu Lys Arg Ser Leu Asp Leu Pro Tyr Pro Ser Ser Phe Ala 
65                  70                  75                  80  


Pro Val Ser Ala Pro Arg Asn Gln Thr Phe Thr Tyr Met Gly Lys Phe 
                85                  90                  95      


Ser Ile Asp Pro Gln Tyr Pro Gly Ala Ser Cys Tyr Pro Glu Gly Ile 
            100                 105                 110         


Ile Asn Ile Val Ser Ala Gly Ile Leu Gln Gly Val Thr Ser Pro Ala 
        115                 120                 125             


Ser Thr Thr Ala Ser Ser Ser Val Thr Ser Ala Ser Pro Asn Pro Leu 
    130                 135                 140                 


Ala Thr Gly Pro Leu Gly Val Cys Thr Met Ser Gln Thr Gln Pro Asp 
145                 150                 155                 160 


Leu Asp His Leu Tyr Ser Pro Pro Pro Pro Pro Pro Pro Tyr Ser Gly 
                165                 170                 175     


Cys Ala Gly Asp Leu Tyr Gln Asp Pro Ser Ala Phe Leu Ser Ala Ala 
            180                 185                 190         


Thr Thr Ser Thr Ser Ser Ser Leu Ala Tyr Pro Pro Pro Pro Ser Tyr 
        195                 200                 205             


Pro Ser Pro Lys Pro Ala Thr Asp Pro Gly Leu Phe Pro Met Ile Pro 
    210                 215                 220                 


Asp Tyr Pro Gly Phe Phe Pro Ser Gln Cys Gln Arg Asp Leu His Gly 
225                 230                 235                 240 


Thr Ala Gly Pro Asp Arg Lys Pro Phe Pro Cys Pro Leu Asp Thr Leu 
                245                 250                 255     


Arg Val Pro Pro Pro Leu Thr Pro Leu Ser Thr Ile Arg Asn Phe Thr 
            260                 265                 270         


Leu Gly Gly Pro Ser Ala Gly Val Thr Gly Pro Gly Ala Ser Gly Gly 
        275                 280                 285             


Ser Glu Gly Pro Arg Leu Pro Gly Ser Ser Ser Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Tyr Asn Pro His His Leu Pro Leu Arg Pro Ile 
305                 310                 315                 320 


Leu Arg Pro Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Val His 
                325                 330                 335     


Glu Arg Pro Tyr Pro Cys Pro Ala Glu Gly Cys Asp Arg Arg Phe Ser 
            340                 345                 350         


Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly His Lys 
        355                 360                 365             


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His 
    370                 375                 380                 


Leu Thr Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
385                 390                 395                 400 


Asp Tyr Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His 
                405                 410                 415     


Thr Lys Ile His Leu Arg Gln Lys Glu Arg Lys Ser Ser Ala Pro Ser 
            420                 425                 430         


Ala Ser Val Pro Ala Pro Ser Thr Ala Ser Cys Ser Gly Gly Val Gln 
        435                 440                 445             


Pro Gly Gly Thr Leu Cys Ser Ser Asn Ser Ser Ser Leu Gly Gly Gly 
    450                 455                 460                 


Pro Leu Ala Pro Cys Ser Ser Arg Thr Arg Thr Pro 
465                 470                 475     


<210>  1159
<211>  11695
<212>  DNA
<213>  Homo Sapiens

<400>  1159
agtatttctc tcgcgagaaa ccgctgcgcg gacgatactt gaagaggtgg ggaaaggagg       60

gggctgcggg agccgcggca gagactgtgg gtgccacaag cggacaggag ccacagctgg      120

gacagctgcg agcggagccg agcagtggct gtagcggcca cgactgggag cagccgccgc      180

cgcctcctcg ggagtcggag ccgccgcttc tccactggca ggggccgcct gaagtgggag      240

cagcgcctgg agaaggcggg aggagcccgg cccgggggac gggcggcggg atagcgggac      300

cccggcggcg cggtgcgctt cagggcgcag cggcggccgc agaccgagcc ccgggcgcgg      360

caagaggcgg cgggagccgg tggcggctcg gcatcatgcg tcgagggcgt ctgctggaga      420

tcgccctggg atttaccgtg cttttagcgt cctacacgag ccatggggcg gacgccaatt      480

tggaggctgg gaacgtgaag gaaaccagag ccagtcgggc caagagaaga ggcggtggag      540

gacacgacgc gcttaaagga cccaatgtct gtggatcacg ttataatgct tactgttgcc      600

ctggatggaa aaccttacct ggcggaaatc agtgtattgt ccccatttgc cggcattcct      660

gtggggatgg attttgttcg aggccaaata tgtgcacttg cccatctggt cagatagctc      720

cttcctgtgg ctccagatcc atacaacact gcaatattcg ctgtatgaat ggaggtagct      780

gcagtgacga tcactgtcta tgccagaaag gatacatagg gactcactgt ggacaacctg      840

tttgtgaaag tggctgtctc aatggaggaa ggtgtgtggc cccaaatcga tgtgcatgca      900

cttacggatt tactggaccc cagtgtgaaa gagattacag gacaggccca tgttttactg      960

tgatcagcaa ccagatgtgc cagggacaac tcagcgggat tgtctgcaca aaaacgctct     1020

gctgtgccac agtcggccga gcctggggcc acccctgtga gatgtgtcct gcccagcctc     1080

acccctgccg ccgtggcttc attccaaata tccgcacggg agcttgtcaa gatgtggatg     1140

aatgccaggc catccccggg ctctgtcagg gaggaaattg cattaatact gttgggtctt     1200

ttgagtgcaa atgccctgct ggacacaaac ttaatgaagt gtcacaaaaa tgtgaagata     1260

ttgatgaatg cagcaccatt cctggaatct gtgaaggggg tgaatgtaca aacacagtca     1320

gcagttactt ttgcaaatgt ccccctggtt tttacacctc tccagatggt accagatgca     1380

tagatgttcg cccaggatac tgttacacag ctctgacaaa cgggcgctgc tctaaccagc     1440

tgccacagtc cataaccaaa atgcagtgct gctgtgatgc cggccgatgc tggtctccag     1500

gggtcactgt cgcccctgag atgtgtccca tcagagcaac cgaggatttc aacaagctgt     1560

gctctgttcc tatggtaatt cctgggagac cagaatatcc tcccccaccc cttggcccca     1620

ttcctccagt tctccctgtt cctcctggct ttcctcctgg acctcaaatt ccggtccctc     1680

gaccaccagt ggaatatctg tatccatctc gggagccacc aagggtgctg ccagtaaacg     1740

ttactgatta ctgccagttg gtccgctatc tctgtcaaaa tggacgctgc attccaactc     1800

ctgggagtta ccggtgtgag tgcaacaaag ggttccagct ggacctccgt ggggagtgta     1860

ttgatgttga tgaatgtgag aaaaacccct gtgctggtgg tgagtgtatt aacaaccagg     1920

gttcgtacac ctgtcagtgc cgagctggat atcagagcac actcacgcgg acagaatgcc     1980

gagacattga tgagtgttta cagaatggcc ggatctgcaa taatggacgc tgcatcaaca     2040

cagatggcag ttttcattgc gtgtgtaatg cgggctttca tgttacacga gatgggaaga     2100

actgtgaaga tatggatgaa tgcagcataa ggaacatgtg ccttaatgga atgtgtatca     2160

atgaagatgg cagttttaaa tgtatttgca aacctggatt ccagctggca tcagatggac     2220

gttattgcaa agacattaac gagtgtgaaa cccctgggat ctgcatgaat gggcgttgcg     2280

tcaacactga tggctcctac agatgtgaat gcttccctgg actggctgtg ggtctggatg     2340

gccgtgtgtg tgttgacaca cacatgcgga gcacatgcta tggtggatac aagagaggcc     2400

agtgtatcaa acctttgttt ggtgctgtca ctaaatctga atgctgttgc gccagcactg     2460

agtatgcatt tggggaacct tgccagccgt gtcctgcaca gaattcagcg gaatatcagg     2520

cactctgcag cagtgggcca ggaatgacgt cagcaggcag tgatataaat gaatgtgcac     2580

tagatcctga tatttgccca aatggaatct gtgaaaacct tcgtgggacc tataaatgta     2640

tatgcaattc aggatatgaa gtggattcaa ctgggaaaaa ctgcgttgat attaatgaat     2700

gtgtactgaa cagtctcctt tgtgacaatg gacaatgtag aaatactcct ggaagttttg     2760

tctgtacctg ccccaaggga tttatctaca aacctgatct aaaaacatgt gaagacattg     2820

atgaatgcga atcaagtcct tgcattaatg gagtctgcaa gaacagccca ggctctttta     2880

tttgtgaatg ttcttctgaa agtactttgg atccaacaaa aaccatctgc atagaaacca     2940

tcaagggcac ttgctggcag actgtcattg atgggcgatg tgagatcaac atcaatggag     3000

ccaccttaaa gtcccagtgc tgctcctccc tcggtgctgc gtggggaagc ccgtgcaccc     3060

tatgccaagt tgatcccata tgtggtaaag ggtactcaag aattaaagga acacaatgtg     3120

aagatataga tgaatgtgaa gtgttcccag gagtgtgtaa aaatggcctg tgtgttaaca     3180

ctagggggtc attcaagtgt cagtgtccca gtggaatgac tttggatgcc acaggaagga     3240

tctgtcttga tatccgcctg gaaacctgct tcctgaggta cgaggacgag gagtgcaccc     3300

tgcctattgc tggccgccac cgcatggacg cctgctgctg ctccgtcggg gcagcctggg     3360

gtactgagga atgcgaggag tgtcccatga gaaatactcc tgagtacgag gagctgtgtc     3420

cgagaggacc cggatttgcc acaaaagaaa ttacaaatgg aaagcctttc ttcaaagata     3480

tcaatgagtg caagatgata cccagcctct gcacccacgg caagtgcaga aacaccattg     3540

gcagctttaa gtgcaggtgt gacagcggct ttgctcttga ttctgaagaa aggaactgca     3600

cagacattga cgaatgccgc atatctcctg acctctgtgg cagaggccag tgtgtgaaca     3660

cccctgggga ctttgaatgc aagtgtgacg aaggctatga aagtggattc atgatgatga     3720

agaactgcat ggatattgat gagtgtcaga gagatcctct cctatgccga ggtggtgttt     3780

gccataacac agagggaagt taccgctgtg aatgcccgcc tggccatcag ctgtccccca     3840

acatctccgc gtgtatcgac atcaatgaat gtgagctgag tgcacacctg tgccccaatg     3900

gccgttgcgt gaacctcata gggaagtatc agtgtgcctg caaccctggc taccattcaa     3960

ctcccgatag gctattttgt gttgacattg atgaatgcag cataatgaat ggtggttgtg     4020

aaaccttctg cacaaactct gaaggcagct atgaatgtag ctgtcagccg ggatttgcac     4080

taatgcctga ccagagatca tgcaccgaca tcgatgagtg tgaagataat cccaatatct     4140

gtgatggtgg tcagtgcaca aatatccctg gagagtacag gtgcttgtgt tatgatggat     4200

tcatggcatc tgaagacatg aagacttgtg tagatgtcaa tgagtgtgac ctgaatccaa     4260

atatctgcct aagtgggacc tgtgaaaaca cgaaaggctc atttatctgc cactgtgata     4320

tgggctactc cggcaaaaaa ggaaaaactg gctgtacaga catcaatgaa tgtgaaattg     4380

gagcacacaa ctgtggcaaa catgctgtat gtaccaatac agcaggaagc ttcaaatgta     4440

gctgcagtcc cgggtggatt ggagatggca ttaagtgcac tgatctggac gaatgttcca     4500

atggaaccca tatgtgcagc cagcatgcag actgcaagaa taccatggga tcttaccgct     4560

gtctgtgcaa ggaaggatac acaggtgatg gcttcacttg tacagacctt gatgagtgct     4620

ctgagaacct gaatctctgt ggcaatggcc agtgcctcaa tgcaccagga ggataccgct     4680

gtgaatgcga catgggcttc gtgcccagtg ctgacgggaa agcctgtgaa gatattgatg     4740

agtgctccct tccgaacatc tgtgtctttg gaacttgcca caacctccct ggcctgttcc     4800

gctgtgagtg tgagataggc tacgaactgg acagaagcgg cgggaactgc acagatgtga     4860

atgaatgcct ggatccaacc acgtgcatca gtgggaactg tgtcaacact ccaggcagct     4920

atatctgtga ctgcccacct gattttgaac tgaacccaac tcgagttggc tgtgttgata     4980

cccgctctgg aaattgctat ttggatattc gacctcgagg agacaatgga gatacagcct     5040

gcagcaatga aattggagtt ggtgtttcca aagcttcctg ctgctgttct ctgggtaaag     5100

cctggggtac tccttgtgag atgtgtcctg ctgtgaacac atccgagtac aaaattcttt     5160

gtcctggagg ggaaggtttc cgaccaaatc ctatcaccgt tatattggaa gatattgatg     5220

agtgccagga gctaccaggg ctgtgccaag gaggaaaatg tatcaacacc tttgggagtt     5280

tccagtgccg ctgtccaacc ggctactacc tgaatgaaga tacacgagtg tgtgatgatg     5340

tgaatgaatg tgagactcct ggaatctgtg gtccagggac atgttacaac accgttggca     5400

actacacctg tatctgtcct ccagactaca tgcaagtgaa tgggggaaat aattgcatgg     5460

atatgagaag aagtttgtgc tacagaaact actatgctga caaccagacc tgtgatggag     5520

aattgttatt caacatgacc aagaagatgt gctgctgttc ctacaacatt ggccgggcgt     5580

ggaacaagcc ctgtgaacag tgtcccatcc caagtacaga tgagtttgct acactctgtg     5640

gaagtcaaag gccaggcttt gtcatcgaca tttataccgg tttacccgtt gatattgatg     5700

agtgccggga gatcccaggg gtctgtgaaa atggagtgtg tatcaacatg gttggcagct     5760

tccgatgtga atgtccagtg ggattcttct ataatgacaa gttgttggtt tgtgaagata     5820

ttgacgagtg tcagaacggc ccagtgtgcc agcgcaacgc cgaatgcatc aacactgcag     5880

gcagctaccg ctgtgactgt aagcccggct accgcttcac ctccacagga cagtgcaatg     5940

atcgtaatga atgtcaagaa atccccaata tatgcagtca tgggcagtgc attgacacag     6000

ttggaagctt ttattgcctt tgccacactg gttttaaaac aaatgatgac caaaccatgt     6060

gcttggacat aaatgaatgt gaaagagatg cctgtgggaa tggaacttgc cggaacacaa     6120

ttggttcctt caactgccgc tgcaatcatg gtttcatcct ttctcacaac aatgactgta     6180

tagatgttga tgaatgtgca agtggaaatg ggaatctttg cagaaatggc caatgcatta     6240

atacagtggg gtctttccag tgccagtgca atgaaggcta tgaggtggct ccagatggga     6300

ggacctgtgt ggatatcaat gaatgtcttc tagaacccag aaaatgtgca ccaggtacct     6360

gtcaaaactt ggatgggtcc tacagatgca tttgcccacc tggatacagt cttcaaaatg     6420

agaagtgtga agatattgat gagtgtgtcg aagagccaga aatttgtgcc ctgggcacat     6480

gcagtaacac tgaaggcagc ttcaaatgtc tgtgtccaga agggttttcc ttgtcctcca     6540

gtggaagaag gtgccaagat ttgcgaatga gctactgtta tgcgaagttt gaaggaggaa     6600

agtgttcatc acccaaatcc agaaatcact ccaagcagga atgctgctgt gccttgaagg     6660

gagaaggctg gggagacccc tgcgagctct gccccacgga acctgatgag gccttccgcc     6720

agatatgtcc ttatggaagt gggatcatcg tgggacctga tgattcagca gttgatatgg     6780

acgaatgcaa agaacccgat gtctgtaaac atggacagtg catcaataca gatggttcct     6840

atcgctgcga gtgtcccttt ggttatattc tagcagggaa tgaatgtgta gatactgatg     6900

aatgttctgt tggcaatcct tgtggaaatg gaacctgcaa gaatgtgatt ggaggttttg     6960

aatgcacctg cgaggaggga tttgagcccg gtccaatgat gacatgtgaa gatataaatg     7020

aatgtgccca gaatcctctg ctctgtgcct tccgatgtgt gaacacttat gggtcatatg     7080

aatgcaaatg tcccgtggga tatgtgctca gagaagaccg taggatgtgc aaagatgagg     7140

atgagtgtga agagggaaaa catgactgta ctgaaaaaca aatggaatgc aagaacctca     7200

ttggcacata tatgtgcatc tgtggacccg ggtatcagcg gagacctgat ggagaaggct     7260

gtgtagatga gaatgaatgt cagacgaagc cagggatctg tgagaatggg cgctgcctca     7320

acacccgtgg gagctacacc tgtgagtgta atgatgggtt taccgccagc cccaaccagg     7380

acgagtgcct tgacaatcgg gaagggtact gcttcacaga ggtgctacaa aacatgtgtc     7440

agatcggctc cagcaacagg aaccccgtca ccaaatcgga atgctgctgt gacggaggga     7500

gaggctgggg tccccactgt gagatctgcc ctttccaggg gactgtggct ttcaagaaac     7560

tctgtcccca tggccgagga ttcatgacca atggagcaga tatcgatgaa tgcaaggtta     7620

ttcacgatgt ttgccgaaat ggggaatgtg tcaatgacag aggatcatat cattgcattt     7680

gtaaaactgg gtacactcca gatataactg ggacttcctg tgtagatctg aacgagtgca     7740

accaggctcc caaaccctgc aattttatct gcaaaaacac agaagggagt taccagtgtt     7800

catgcccgaa aggctacatt ctgcaagagg atggaaggag ctgcaaagat cttgatgagt     7860

gtgcaaccaa gcaacacaac tgccagttcc tatgtgttaa caccattggc ggcttcacat     7920

gcaaatgtcc tcccggattt acccaacacc atacgtcctg cattgataac aatgaatgca     7980

cctctgacat caatctgtgc gggtctaagg gcatttgcca gaacactcct ggaagcttca     8040

cctgtgaatg ccagcgggga ttctcacttg atcagaccgg ctccagctgt gaagacgtgg     8100

acgagtgtga gggtaaccac cgctgccagc atggctgcca gaacatcatt gggggctaca     8160

ggtgcagctg cccccagggc tacctccagc actaccagtg gaaccagtgt gttgatgaaa     8220

acgaatgcct cagcgctcac atctgcggag gagcctcctg tcacaacacc ctggggagct     8280

acaagtgcat gtgtcccgcc ggcttccagt atgaacagtt cagtggagga tgccaagaca     8340

tcaatgaatg tggctctgcg caggccccct gcagctatgg ctgttccaat accgagggcg     8400

gttacctgtg tggctgtcca cctggttact tccgcatagg ccaagggcac tgtgtttctg     8460

gaatgggcat gggccgagga aacccagagc cacctgtcag tggtgaaatg gatgacaatt     8520

cactctcccc agaggcttgt tacgagtgta agatcaatgg ctaccccaaa cggggcagga     8580

aacggagaag cacaaacgaa actgatgcct ccaatatcga ggatcagtct gagacagaag     8640

ccaatgtgag tcttgcaagt tgggatgttg agaagacagc catctttgct ttcaatattt     8700

cccacgtcag taacaaggtt cgaatcctag aactccttcc agctcttaca actctgacga     8760

atcacaacag atacttgatc gaatctggaa atgaagatgg cttctttaaa atcaaccaaa     8820

aggaagggat cagctacctc cacttcacaa agaagaagcc agtggctgga acctattcat     8880

tacaaatcag tagtactcca ctttataaaa agaaagaact taaccaacta gaagacaaat     8940

atgacaaaga ctacctcagt ggtgaactgg gtgataatct gaagatgaaa atccaggttt     9000

tgcttcatta attcaccatc cagagaccaa ataattaaaa gaaaaacaaa tatagatagg     9060

tagaactata ttttccccca atcagaatca tcatatcata ggtacaatct ttcaccaagt     9120

aaatttgtat aaataagcac tattctttgt attaccaaag caaggtacag gtgactaccc     9180

tagttcaaaa caaccacttt ctcaggcttc tcatgtgtgt agctaagcta ccttgtcata     9240

tgtgttgatt cttgaaaact gggacgtgta tttccattgg gggttggcca tttatgctga     9300

catgccatcc ttccagcaaa cgtacgggaa tgtgctttca attgatggac tactctattt     9360

tttgcaaatt tgtaaacttt gcttctccaa atacaagtac taggttgtcc atttatggta     9420

cctatttggt gctagtaaat tttcaaacta gatttataaa tgcactgtaa tatgtacaca     9480

acttagaaac caaattacaa gtattcagtt ccaatacttc attaatttca atcaaccaaa     9540

gttagttcag tagcttatct cagttatgag tataatacat tacatgtaaa ttaagtgtgt     9600

gtatactgta atcgtgctat tttttatcat tgaaacattt ataaactaga ataataatgc     9660

ccttaatgtg agggtttgta atggtgctta ttaagaccaa agacttgtta aatgtataca     9720

ccaagtggta atgaaatttc ggtgactggc ccacacgtgc atagaggtct gggaggacca     9780

ggaaacagcc tcagtggcca gaggatcacc agtgcatcct tcatcacagc atgtgcaata     9840

tgccaagatt accctcggtc attcctgtca acaaggggtc aatgtcataa atgtcacaat     9900

aaaacaatct cttctttttt ttagtttacc ccttggcttt gtgttcttgc atggatttgg     9960

ggttggaggg gccattccgg aggctaaata aagtctcctg gatttaaatt atcctgggtc    10020

tcttacttat ggcttatgaa agtaccaaat gtataaccac tagaagaaaa tttaacatat    10080

gagtcgatcc cttgttttat ccattgaaag tagcagagtc tggtgtcatt aacctgactt    10140

gcttgtgaga aatttagatt gtagagtcat ttctgaaaca tgacctaatt catcttgtga    10200

cttttaaata gtcttaaata ccaagttcag tcattgtctt agagcacatg aatttcatta    10260

taatagattt atcatgcccc cctctcaaat atacacagtt ttggcaagcc ttaggtgttc    10320

tgttccattt ttttttcccc taaacatctt tcgttagtca atgctcatct aattacaaag    10380

ggataatccc agactgtatc caattgctgt aacttttggt ttcttaatgt cataattttt    10440

aaagtctgtt ttattttaag tgcaatattg agtatttagc tgttaggctc aatccgtcga    10500

tatgaaataa ttttttaaat ccctaagggc aggaaagcat ttcgtggtag tgaaaataag    10560

aggaaataag atggcatgaa ggtggtgggc ggagaaacta ggtaggacac aggaaagtgc    10620

tctcaaaaat ctttgaagag ctcagctgaa aaaaatggag tagatttggc tcatactatt    10680

ccggaaggca aaaccagggt cagctgatgt cagccccagt ttaatacaca cggtcccaat    10740

tatagagcta ctcactgaaa gaatgggttt ccttgcattg tggtgagctc cctgtcacaa    10800

gatagaagag tttcagtcta ggcttaatgg caaccattgg acaaagatgc tttcttccac    10860

ctaacaggcc attaacatct taaaggtatt tttgtatctc taattttgtt tataataggt    10920

gctcaacaga atgagctgaa tggctgttac aaagggggtt tgtaccttgg gtaagagatt    10980

aaaatataac tcaaaatttc cttctaacgc tgcacctatg gaaccatgtg atagaggtgt    11040

attaaaattg ttatcgaaga atatatagca tatggtaaac aacagtttgc atatggaaaa    11100

tgtctttgat aatttaacca gaactgcatt atattcaata acggattttc tttataacaa    11160

acaacagggg aaaatggagt tggcacacag tggatcactt tgatattttt aatagtccaa    11220

gtctggattt tatttattcc tgagccaaca attttgaaca gcatattttc catgtttctg    11280

actgtaacaa aacattttcc tcattgttcc attgtaaata ttcctcttgt tggaactctt    11340

tttaatcctg agatttaaac ctgtaccttt caattgtctg tgacctttca atttcacttt    11400

caatagttga agaacttggc tttgtaaatc tctcagaagc ttgaaaatat cttgtctcta    11460

ccccctcagc ccatttcatt tgccaataat tattttgtaa gtagggttga aatgaactca    11520

gctggccttg tgaaatgttt aaacttgcac aaacaactac atttttgttc aacaaatagc    11580

agtttactca gccaaaatca ctttggatat tgccattaca aatactgtta aacttcagaa    11640

atcatgtctg taaattagat gagccaaaat aaaggacaat tgggttgatg ctgca         11695


<210>  1160
<211>  2871
<212>  PRT
<213>  Homo Sapiens

<400>  1160

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  1161
<211>  2069
<212>  DNA
<213>  Homo Sapiens

<400>  1161
atgctgccgg actggaagag ctccttgatc ctcatggctt acatcatcat cttcctcact       60

ggcctccctg ccaacctcct ggccctgcgg gcctttgtgg ggcggatccg ccagccccag      120

cctgcacctg tgcacatcct cctgctgagc ctgacgctgg ccgacctcct cctgctgctg      180

ctgctgccct tcaagatcat cgaggctgcg tcgaacttcc gctggtacct gcccaaggtc      240

gtctgcgccc tcacgagttt tggcttctac agcagcatct actgcagcac gtggctcctg      300

gcgggcatca gcatcgagcg ctacctggga gtggctttcc ccgtgcagta caagctctcc      360

cgccggcctc tgtatggagt gattgcagct ctggtggcct gggttatgtc ctttggtcac      420

tgcaccatcg tgatcatcgt tcaatacttg aacacgactg agcaggtcag aagtggcaat      480

gaaattacct gctacgagaa cttcaccgat aaccagttgg acgtggtgct gcccgtgcgg      540

ctggagctgt gcctggtgct cttcttcatc cccatggcag tcaccatctt ctgctactgg      600

cgttttgtgt ggatcatgct ctcccagccc cttgtggggg cccagaggcg gcgccgagcc      660

gtggggctgg ctgtggtgac gctgctcaat ttcctggtgt gcttcggacc ttacaacgtg      720

tcccacctgg tggggtatca ccagagaaaa agcccctggt ggcggtcaat agccgtggtg      780

ttcagttcac tcaacgccag tctggacccc ctgctcttct atttctcttc ttcagtggtg      840

cgcagggcat ttgggagagg gctgcaggtg ctgcggaatc agggctcctc cctgttggga      900

cgcagaggca aagacacagc agaggggaca aatgaggaca ggggtgtggg tcaaggagaa      960

gggatgccaa gttcggactt cactacagag tagcagtttc cctggacctt cagaggtcgc     1020

ctgggttaca caggagctgg gaagcctggg agaggcggag caggaaggct cccatccaga     1080

ttcagaaatc cttagaccca gcccaggact gcgactttga aaaaaatgcc tttcaccagc     1140

ttggtatccc ttcctgactg aattgtccta ctcaaaggag cataagtcag agatgcacga     1200

agaagtagtt aggtatagaa gcacctgccg ggtgtggtgg ctcatgccta taatcccaga     1260

actttgggag gctgaggcag gtggatcact tgaggtcggg agattgagaa catcctggtc     1320

aacatgggaa aaccccgtct ctactaaaaa tacaaaaaaa ttagctgggc atggtggcac     1380

atgcctataa tcccagctac tctggaggct gaggcaggag aatccttgaa cccgggagtt     1440

ggaggttgca gtgagctgag atcacgccac tgcactccag cctagcgaca gagcaagact     1500

ccatttaaaa aaaaaaaaaa aaaaaaaaag aagcaccttc aggctggaga agcagcgtag     1560

ctaacacaag tccagtcctt gtgatgtggc tggtagttgg ggatggccag gctgaagcag     1620

agagtcctag agaaatctcg atacaagctt caaagcaaca cctagacact gctctagcgg     1680

ttgatcctgg agataaacca acaagagaga gatggaagag aaatactaaa tgaggtcaaa     1740

gaagactcag aaaggttctg agcctggaga tgagcaggga ggcctcaggg cttagacctt     1800

taatgatagg ggtttccctg cattggtttg acctgttgcc tttttgatgt gctctgtttg     1860

ttttcatgtg ttgtcttgtc tcccctgcta aactgggagc tgccaggggt ctgggtctta     1920

tctccttcct ccatggtacc ccacacaggc caggatgtgg tttggtaccc agcaatcaga     1980

gattggcact ccctcataca ggggaaagca acctggtcta gcaaattgaa aataaagatg     2040

ataaaactct gaaaaaaaaa aaaaaaaaa                                       2069


<210>  1162
<211>  330
<212>  PRT
<213>  Homo Sapiens

<400>  1162

Met Leu Pro Asp Trp Lys Ser Ser Leu Ile Leu Met Ala Tyr Ile Ile 
1               5                   10                  15      


Ile Phe Leu Thr Gly Leu Pro Ala Asn Leu Leu Ala Leu Arg Ala Phe 
            20                  25                  30          


Val Gly Arg Ile Arg Gln Pro Gln Pro Ala Pro Val His Ile Leu Leu 
        35                  40                  45              


Leu Ser Leu Thr Leu Ala Asp Leu Leu Leu Leu Leu Leu Leu Pro Phe 
    50                  55                  60                  


Lys Ile Ile Glu Ala Ala Ser Asn Phe Arg Trp Tyr Leu Pro Lys Val 
65                  70                  75                  80  


Val Cys Ala Leu Thr Ser Phe Gly Phe Tyr Ser Ser Ile Tyr Cys Ser 
                85                  90                  95      


Thr Trp Leu Leu Ala Gly Ile Ser Ile Glu Arg Tyr Leu Gly Val Ala 
            100                 105                 110         


Phe Pro Val Gln Tyr Lys Leu Ser Arg Arg Pro Leu Tyr Gly Val Ile 
        115                 120                 125             


Ala Ala Leu Val Ala Trp Val Met Ser Phe Gly His Cys Thr Ile Val 
    130                 135                 140                 


Ile Ile Val Gln Tyr Leu Asn Thr Thr Glu Gln Val Arg Ser Gly Asn 
145                 150                 155                 160 


Glu Ile Thr Cys Tyr Glu Asn Phe Thr Asp Asn Gln Leu Asp Val Val 
                165                 170                 175     


Leu Pro Val Arg Leu Glu Leu Cys Leu Val Leu Phe Phe Ile Pro Met 
            180                 185                 190         


Ala Val Thr Ile Phe Cys Tyr Trp Arg Phe Val Trp Ile Met Leu Ser 
        195                 200                 205             


Gln Pro Leu Val Gly Ala Gln Arg Arg Arg Arg Ala Val Gly Leu Ala 
    210                 215                 220                 


Val Val Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro Tyr Asn Val 
225                 230                 235                 240 


Ser His Leu Val Gly Tyr His Gln Arg Lys Ser Pro Trp Trp Arg Ser 
                245                 250                 255     


Ile Ala Val Val Phe Ser Ser Leu Asn Ala Ser Leu Asp Pro Leu Leu 
            260                 265                 270         


Phe Tyr Phe Ser Ser Ser Val Val Arg Arg Ala Phe Gly Arg Gly Leu 
        275                 280                 285             


Gln Val Leu Arg Asn Gln Gly Ser Ser Leu Leu Gly Arg Arg Gly Lys 
    290                 295                 300                 


Asp Thr Ala Glu Gly Thr Asn Glu Asp Arg Gly Val Gly Gln Gly Glu 
305                 310                 315                 320 


Gly Met Pro Ser Ser Asp Phe Thr Thr Glu 
                325                 330 


<210>  1163
<211>  3349
<212>  DNA
<213>  Homo Sapiens

<400>  1163
agttggtgtc atgcaagaat ctattcacac tgactaaaga tattggaaga gtgaagatca       60

gagaatttta agtctgaaat ttggcatcac tgccctgaac aatataacct tagttggcat      120

aaactactca tacagacaaa ggcattatcc atcacaataa gtaacttttt gtctttattt      180

caaccggaca atcgtgatta gaaaagctcc tgtgacaaaa ttcaagaaaa cctgacataa      240

atgaacaaca atacaacatg tattcaacca tctatgatct cttccatggc tttaccaatc      300

atttacatcc tcctttgtat tgttggtgtt tttggaaaca ctctctctca atggatattt      360

ttaacaaaaa taggtaaaaa aacatcaacg cacatctacc tgtcacacct tgtgactgca      420

aacttacttg tgtgcagtgc catgcctttc atgagtatct atttcctgaa aggtttccaa      480

tgggaatatc aatctgctca atgcagagtg gtcaattttc tgggaactct atccatgcat      540

gcaagtatgt ttgtcagtct cttaatttta agttggattg ccataagccg ctatgctacc      600

ttaatgcaaa aggattcctc gcaagagact acttcatgct atgagaaaat attttatggc      660

catttactga aaaaatttcg ccagcccaac tttgctagaa aactatgcat ttacatatgg      720

ggagttgtac tgggcataat cattccagtt accgtatact actcagtcat agaggctaca      780

gaaggagaag agagcctatg ctacaatcgg cagatggaac taggagccat gatctctcag      840

attgcaggtc tcattggaac cacatttatt ggattttcct ttttagtagt actaacatca      900

tactactctt ttgtaagcca tctgagaaaa ataagaacct gtacgtccat tatggagaaa      960

gatttgactt acagttctgt gaaaagacat cttttggtca tccagattct actaatagtt     1020

tgcttccttc cttatagtat ttttaaaccc attttttatg ttctacacca aagagataac     1080

tgtcagcaat tgaattattt aatagaaaca aaaaacattc tcacctgtct tgcttcggcc     1140

agaagtagca cagaccccat tatatttctt ttattagata aaacattcaa gaagacacta     1200

tataatctct ttacaaagtc taattcagca catatgcaat catatggttg acttttgaat     1260

ggaaaacccc acaatattaa gaaaagcatt catgtgactt tattagggac actaaactac     1320

atcattaaca tgtcacagct tggttgacaa taatcaccaa gaaaatctct ttggttttta     1380

aaaataaata aacatatatt cataaaactc aaaaaacagt tatactgaac gttgagatgg     1440

cagaaacttt cagaagcaaa aattaagcat attgaaagga tcccactcat atgaaactaa     1500

caggctgttt tctgtttaaa ctcaactgtc agtgcttctg ttcagaacac gttatttcat     1560

gactaggata aagaagcaaa tggtttatga cttgtctgct ttctggtagt tagaatacaa     1620

gggtcaatct atggctagtg tttattggta attttaaaat ctttaaaaat aagtagctgg     1680

gcacagtggc ttacgcctgt aatcccagca ctttgggagg ctgaggtggg tggatcattt     1740

tgaggtcagg agttcaagac cagcctgggc aacatggtga aaccctgtct ctactaaaaa     1800

tacaaaaatc agctggacat ggtggtgggc gcctgtaatc ccagctactc gggaggctga     1860

ggcaggagaa tcgcttgagc ccgggacgga ggttgcagtg agcggagatc gtgccactgc     1920

actacagcct gggaggcaga gcgagactct gtctcataaa acaaaacaaa aaaataaaaa     1980

taagtaaaaa aataaataag aaatatcctc attcacatct tacctaaatg catgaataat     2040

acagtgaaaa aaatccaagg ttttataaac atattattta tttgaaatta tctggctcat     2100

gttattgggg agaagcaata ttcattgact atatttttaa agcagatgat acttataaaa     2160

atgcttaaat atttggatta ggctttgtca aagtaaaaag ctatgtcatt atatgcccat     2220

cttcatcaca ttgtgcatat tttcttctgt attcaatata aataatgtta ttagtgacaa     2280

acagtacctg gcagttaatt ttttgtgaaa taaatgaatg aataataagg gagtgtaata     2340

gtattgcagt taagagattg atctctgaag ttatacttct tgggttcaat ctggctctac     2400

tttttattta gctggacaat cttaggcaaa ttaacttatc ctctgtacgt gttaatttct     2460

tcatttgtag agcagaaaat actatcttat ttacagatcc tattattaaa tcagctgtta     2520

ctattatgag tagctaacgc ttagtaagca cttgctgttt gccaagcatt ctacttatat     2580

gctttacata tattatttta atcaccacaa ctctaaagta tactaattta ctgatgaaaa     2640

tattgaagtg ggctgggtgc ggtggctcat gcctgtaatc ccagcactct gggaggccga     2700

ggtgggcaga tcacctgagg tcaggagttc gagactagcc tggccaacat ggcgaaaccc     2760

acctctacta aaaatacaaa aattagctgg gcgtggtggt gtgtgcctgt agtcccagct     2820

acttgggagg ctgaggcaga agaatcactt gaactcggga ggctgaggca ggagaatcac     2880

ttgaactcag gaggcggagg ttgcagtgag ccaagatcat gccattgcac tccagcctgg     2940

gcgacagagt gagactctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaatata     3000

tatatatata tatatatata tgtatgtatg tatgtatatg tgcatagtta agtaaatcac     3060

cccaattttt tctaatattt aagtgaacat ttaaagataa gcatttctta atgttaattt     3120

cttttctttc atgtaatctt gtcagtagac aaatgatggt gactatattc tgtaataagt     3180

acatatatta tgattaaaaa aaaaagcgtg tactatctgc ccaaagagat cataagcact     3240

ttggagctat aaacttcttg tctatttcta cttccatggt actgatattc tcttctcaga     3300

taaccaaaca aaaacagctg aataaaatca accattaata gtaacttgc                 3349


<210>  1164
<211>  336
<212>  PRT
<213>  Homo Sapiens

<400>  1164

Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met 
1               5                   10                  15      


Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly 
            20                  25                  30          


Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr 
        35                  40                  45              


Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val 
    50                  55                  60                  


Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln 
65                  70                  75                  80  


Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr 
                85                  90                  95      


Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp 
            100                 105                 110         


Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln 
        115                 120                 125             


Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys 
    130                 135                 140                 


Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp 
145                 150                 155                 160 


Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val 
                165                 170                 175     


Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met 
            180                 185                 190         


Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr 
        195                 200                 205             


Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe 
    210                 215                 220                 


Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys 
225                 230                 235                 240 


Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile 
                245                 250                 255     


Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe 
            260                 265                 270         


Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile 
        275                 280                 285             


Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr 
    290                 295                 300                 


Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu 
305                 310                 315                 320 


Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly 
                325                 330                 335     


<210>  1165
<211>  2168
<212>  DNA
<213>  Homo Sapiens

<400>  1165
ggagttagcc tcgctcaggg cgcggctaag gcgcccagat ggcctgcggg cgccaccacg       60

tccctggtcc cagctcggga gcacatcaga ggcttagagg cgagtgggaa gggactcaga      120

cagtgcagga cgagaaacgc ccgcggcacc aaagcccctc agagcgtcgc ccccgcctct      180

agttctagaa agtcagtttc ccggcactgg caccccggaa cctcaggggc tgccgagctg      240

ggggggcgct caagctgcga ggatccgggc tgcccgcgag acgaggagcg ggcgcccagg      300

atggggtgca tgaagtccaa gttcctccag gtcggaggca atacattctc aaaaactgaa      360

accagcgcca gcccacactg tcctgtgtac gtgccggatc ccacatccac catcaagccg      420

gggcctaata gccacaacag caacacacca ggaatcaggg aggcaggctc tgaggacatc      480

atcgtggttg ccctgtatga ttacgaggcc attcaccacg aagacctcag cttccagaag      540

ggggaccaga tggtggtcct agaggaatcc ggggagtggt ggaaggctcg atccctggcc      600

acccggaagg agggctacat cccaagcaac tatgtcgccc gcgttgactc tctggagaca      660

gaggagtggt ttttcaaggg catcagccgg aaggacgcag agcgccaact gctggctccc      720

ggcaacatgc tgggctcctt catgatccgg gatagcgaga ccactaaagg aagctactct      780

ttgtccgtgc gagactacga ccctcggcag ggagataccg tgaaacatta caagatccgg      840

accctggaca acgggggctt ctacatatcc ccccgaagca ccttcagcac tctgcaggag      900

ctggtggacc actacaagaa ggggaacgac gggctctgcc agaaactgtc ggtgccctgc      960

atgtcttcca agccccagaa gccttgggag aaagatgcct gggagatccc tcgggaatcc     1020

ctcaagctgg agaagaaact tggagctggg cagtttgggg aagtctggat ggccacctac     1080

aacaagcaca ccaaggtggc agtgaagacg atgaagccag ggagcatgtc ggtggaggcc     1140

ttcctggcag aggccaacgt gatgaaaact ctgcagcatg acaagctggt caaacttcat     1200

gcggtggtca ccaaggagcc catctacatc atcacggagt tcatggccaa aggaagcttg     1260

ctggactttc tgaaaagtga tgagggcagc aagcagccat tgccaaaact cattgacttc     1320

tcagcccaga ttgcagaagg catggccttc atcgagcaga ggaactacat ccaccgagac     1380

ctccgagctg ccaacatctt ggtctctgca tccctggtgt gtaagattgc tgactttggc     1440

ctggcccggg tcattgagga caacgagtac acggctcggg aaggggccaa gttccccatc     1500

aagtggacag ctcctgaagc catcaacttt ggctccttca ccatcaagtc agacgtctgg     1560

tcctttggta tcctgctgat ggagatcgtc acctacggcc ggatccctta cccagggatg     1620

tcaaaccctg aagtgatccg agctctggag cgtggatacc ggatgcctcg cccagagaac     1680

tgcccagagg agctctacaa catcatgatg cgctgctgga aaaaccgtcc ggaggagcgg     1740

ccgaccttcg aatacatcca gagtgtgctg gatgacttct acacggccac agagagccag     1800

taccaacagc agccatgata gggaggacca gggcagggcc agggggtgcc caggtggtgg     1860

ctgcaaggtg gctccagcac catccgccag ggcccacacc cccttcctac tcccagacac     1920

ccaccctcgc ttcagccaca gtttcctcat ctgtccagtg ggtaggttgg actggaaaat     1980

ctctttttga ctcttgcaat ccacaatctg acattctcag gaagccccca agttgatatt     2040

tctatttcct ggaatggttg gattttagtt acagctgtga tttggaaggg aaactttcaa     2100

aatagtgaaa tgaatattta aataaaagat ataaatgcca aagtctttac caaaaaaaaa     2160

aaaaaaaa                                                              2168


<210>  1166
<211>  526
<212>  PRT
<213>  Homo Sapiens

<400>  1166

Met Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Ala Gly Ser Glu Asp 
65                  70                  75                  80  


Ile Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp 
                85                  90                  95      


Leu Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly 
            100                 105                 110         


Glu Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile 
        115                 120                 125             


Pro Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp 
    130                 135                 140                 


Phe Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala 
145                 150                 155                 160 


Pro Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr 
                165                 170                 175     


Lys Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly 
            180                 185                 190         


Asp Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe 
        195                 200                 205             


Tyr Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp 
    210                 215                 220                 


His Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro 
225                 230                 235                 240 


Cys Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu 
                245                 250                 255     


Ile Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln 
            260                 265                 270         


Phe Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala 
        275                 280                 285             


Val Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala 
    290                 295                 300                 


Glu Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu 
305                 310                 315                 320 


His Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met 
                325                 330                 335     


Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys 
            340                 345                 350         


Gln Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly 
        355                 360                 365             


Met Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala 
    370                 375                 380                 


Ala Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe 
385                 390                 395                 400 


Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly 
                405                 410                 415     


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly 
            420                 425                 430         


Ser Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met 
        435                 440                 445             


Glu Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro 
    450                 455                 460                 


Glu Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu 
465                 470                 475                 480 


Asn Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn 
                485                 490                 495     


Arg Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp 
            500                 505                 510         


Asp Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 525     


<210>  1167
<211>  220
<212>  RNA
<213>  Homo Sapiens

<400>  1167
ggaaagagaa aagagaaagg gggaaggaga cggaaaaaag aaagaacaaa gaggaaggac       60

aaagagaggg agcagggggc gggggcagga aagggggcac gacgggagcg aaggaggcac      120

gaggcggaga aaaacagggg gaacaacagc caagaaaacc caagaacagc caccaacagc      180

cggcacccaa aaccaacagg caaaaaggcc ggacgaccaa                            220


<210>  1168
<211>  49
<212>  RNA
<213>  Homo Sapiens

<400>  1168
cgccagagcc gcaacaccac aggacccaga aagcagcacg gcgagacgc                   49


<210>  1169
<211>  6915
<212>  DNA
<213>  Homo Sapiens

<400>  1169
cctctgagcc cagccctccc tagcatcacc acttccatcc cattcctcag ccaagagcca       60

ggaatcctga ttccagatcc cacgcttccc tgcctccctc aggtcccagc tcttgctcct      120

gcctgtttgc ctggaaatgg ccacgcttct ccttctcctt ggggtgctgg tggtaagccc      180

agacgctctg gggagcacaa cagcagtgca gacacccacc tccggagagc ctttggtctc      240

tactagcgag cccctgagct caaagatgta caccacttca ataacaagtg accctaaggc      300

cgacagcact ggggaccaga cctcagccct acctccctca acttccatca atgagggatc      360

ccctctttgg acttccattg gtgccagcac tggttcccct ttacctgagc caacaaccta      420

ccaggaagtt tccatcaaga tgtcatcagt gccccaggaa acccctcatg caaccagtca      480

tcctgctgtt cccataacag caaactctct aggatcccac accgtgacag gtggaaccat      540

aacaacgaac tctccagaaa cctccagtag gaccagtgga gcccctgtta ccacggcagc      600

tagctctctg gagacctcca gaggcacctc tggaccccct cttaccatgg caactgtctc      660

tctggagact tccaaaggca cctctggacc ccctgttacc atggcaactg actctctgga      720

gacctccact gggaccactg gaccccctgt taccatgaca actggctctc tggagccctc      780

cagcggggcc agtggacccc aggtctctag cgtaaaacta tctacaatga tgtctccaac      840

gacctccacc aacgcaagca ctgtgccctt ccggaaccca gatgagaact cacgaggcat      900

gctgccagtg gctgtgcttg tggccctgct ggcggtcata gtcctcgtgg ctctgctcct      960

gctgtggcgc cggcggcaga agcggcggac tggggccctc gtgctgagca gaggcggcaa     1020

gcgtaacggg gtggtggacg cctgggctgg gccagcccag gtccctgagg agggggccgt     1080

gacagtgacc gtgggagggt ccgggggcga caagggctct gggttccccg atggggaggg     1140

gtctagccgt cggcccacgc tcaccacttt ctttggcaga cggaagtctc gccagggctc     1200

cctggcgatg gaggagctga agtctgggtc aggccccagc ctcaaagggg aggaggagcc     1260

actggtggcc agtgaggatg gggctgtgga cgccccagct cctgatgagc ccgaaggggg     1320

agacggggct gccccttaag tgtcggtgaa tagtgaggct ggaggccgga atctcagcca     1380

gcctccagca ccttccctct caccatccca ctgccccctc gctcccatgt ttccacccgg     1440

caccctgatc ctcacccgaa tctccttttt ttttttcttt tgagacagag tttcgctttg     1500

tcgcccaggc tggagtgcaa tgcacgatct cagttcactg caacctctgc ctcctaagtt     1560

caggcgattc tcctgcctca gcttcccgag taactgagat tacaggcacc caccaccatg     1620

cccagctgct tttttgtatt tttggtagag atggggtttc accatgttgg ctaggctggt     1680

ctcaaactcc tgacctcagg tgatctacct gcctcagcct cccaaagtgc tgagattaca     1740

gacatgagcc tccgcgcctt gcctcctcac ccacctcttc actctgaatc ctcatgaggc     1800

ttctcagccc tggatttcct gctgccatcc tcacccagca cccacaacta gcgcctgggc     1860

agggcagggc tggcacctct caacgtctgt ggactgaatg aataaaccct cctcatccac     1920

ccctatttat ctccatcacc atttccccct ctttcttgtt cctggaaacg gctgctgagt     1980

ctccatcggc caaacttatc tgccctgtga tttctttgac aattctcctt ttcccccaga     2040

acccaccctg ggttgaccag agtctgggaa gaaggacaag agaacccggc aaactccctc     2100

ctaggattaa ctttgtaaag cacccttgcc ctgtagctgc aagggctgtg gaacctgggc     2160

agcccgcaac cacctttagc tctgggcccc ccaggccagc ctggagcatg gctgggtggg     2220

gccaccagcc catgctctca ggcgggcctg tgatctttcc cagggcacat ggactgtagg     2280

ctggccctgg cccacaccac cacactctcc ccagccatgg acagaggcag ccagaggcct     2340

cacggtttct cctccgagtt tctggctggg tgtagttctc agaaacccca gtgcctgcgt     2400

gtgtccactc gtgggtgtgg tttgtgtgca agagctgagg atttggcgat gcttgggagg     2460

ggtagttgtg ggtacagacg gtgtgggggt gggaagtggt gcagagactg aagagggtca     2520

acctgggcat gggggacaca gggactgctg agaacgtgcg tgtcatcttt gctctgatgg     2580

ggtggacata gcagaaaatc taactctgtc tgtagcccca tacagaatgc cagggtgagc     2640

acagtggctg gtgcctttaa tcccagcact ttggaaagtt gaggcaggag gatcgcttga     2700

gcccaggagt tcgagtctga agtgagctgt gattgcacca ctgcacttca gcctgggcaa     2760

cagagtgagc ccctgtctca aaaaagaaaa gaaaaagaaa gccaggcttc atggaaagat     2820

cgtatgtgtg acccaaatat gagttcttca gctcagccat ggtaatccct tccttgaagt     2880

ctccatttct gcagtacaca tgcatgtgcg ctctctctct ctctctctct ctcacacaca     2940

cacacacaca cacacacaca cgcgcgcgcg cgcgcgctct cctgcgaaca gaggcagggg     3000

gagaggggtt tgccctggtc tcggggactg gtctggctgg cgcttcccca ctgcacgttt     3060

ccaggtttag tttgtctgtg tctcctcttc catcccaggg gctgagcccc ttccatcctc     3120

caagaggaac cagtgagagt gagtgaagga ggggcctgga gccagggact tcccctgtgg     3180

ggcctgggtg gagaggggag aactcaatgg tgctgccttt gagaccagcc caggctacag     3240

cccaggagca cacatgggcc agggcagttg gtatttcccg aggacaaaga ggaaattttc     3300

aaagaggaag ttgttgagtt agagcttgcg gtggctgaga gcagacaggt tgacctgcaa     3360

aaaaagacag gggaggcatg tgagtgtgac agccctgctc tgtggcctgg gcaggagatg     3420

ggggaaaggg tcaggtgggg gatgggctcg tgcagtggga gaggagacgg agggagggag     3480

cgggaagggg cttgcttagt gggtgggaag agctgagctc ggatggaacc agcttctacc     3540

agccaggctg ggcacccact gggctgcatc tggtggcctt ttctgattgc tatttggact     3600

cactgcagct gcagaatgac agaggccatg tccaaaatcc cttagagaca ctgttgtctt     3660

agagttgtta aaataagagc ccccatatca ggtttagaaa atactgtcac cgaacgaacg     3720

tcgctgtcct cagctccacc tccctttcct ttgacagata tggttgtttt ctaagccagg     3780

actggtttta gtcaggtcct gggcgaatcc tgaaaaaaag aggtagtacg ggtaaggaag     3840

gcacccaaca gggctttcac aatccagaaa atatcaaaat ataagtgtta aaagagaggc     3900

acaggccggg tgcggtggct cacgcctgta atctcagcac tttgggaggc caaggtgggc     3960

agatcatgag gtcaggagtt tgagaccagc ctggccaata tgatgaaacc ccgtttctac     4020

taaaaataca aaagttagcc aggcatggtg gtgtgctcct gtaatcccag ctacttagga     4080

ggctgaggcc agagaattgc ttgaaccctg gagtcagagg ttgcagtgag ccgggatcat     4140

gccactgtac tccaggctgg gtgacaaagt gagactgtct caaaaaataa aaataaataa     4200

aataaataaa agagaggcac aaacagtgtt atgaatgcac caaggaaaat ggtgcattca     4260

taactctcag gtgaagccta ccaagccatg cgtgtgtgca catatgtgtg tacgtgtgca     4320

tgtgcgtgcg tgcatgtgcg tgcgtgcatg tgcctgtgtg tgtatgtgtg cacatgtgtg     4380

tgcgcatgtg tgtgtgtgcg cgcatgtgtg tgtgcatgca tgttctccca tgcatgtgta     4440

ctgtggcaag ggagactttg aggaagagat tccagtggct gagcagaagg gctcgcattg     4500

ccctggcgaa aggttggaag gcttcacctg agagtgtgtc gtggcctttg tcatatccac     4560

tgcttgattc ctttctttaa aaattatttt tattgttttc tacatatgag aaccaccaca     4620

cctggctaat ttttgtattt tttgtagaga tggggtttca ccatgttgtc ccggctggtc     4680

tcaaactccc gggcacaaga gatccacctg cctcagcctc ccaaaatgct gggactatag     4740

gcatgagcca ctgcacccag ccactgcttc attcctggtg gctgctgtgc ctggcatgtt     4800

gcagatcctc catgaatatg catttgaatg aatgaatgaa tgaatgaatg aatgaatgga     4860

gatgacgcct cagagattct ttcttttgag atgaggtctc attctgtcac ccagactaga     4920

gggcagtggt gcaatcacag ctcaccacag cctcaacctc ctgggcctcc caagtagctg     4980

cgatcacagg tgtgcaccaa catgcccagc taattttttt ttttaatttt taatttgtac     5040

agacagggtc ttgctgtgtt gcccaggctg gtctcaaact cctgggctca agtggtcctc     5100

ccacctaagc ttccccaaat actgggatta taggtgtgag ccactgtgcc caggcttgcc     5160

tcagatattt gaaggctggg aaggattttg caaagctggg aaaaggaaaa ggcattccca     5220

gcagagggga tagcaggtgg aaatacataa ttaaaaaaaa aaaacgtgga gcagatccag     5280

cgcagtggct catgcctgta atcccagcac tttgggaggc agagcaggga ggattgcttg     5340

agtctaggag ttcaagacca gcctgggtaa catagaaaga ccctgtctct acaaaaacac     5400

aaaaaattag ccaggcgtgg tggtgcatgc ctgtagtacc agctacttga gaagctgagg     5460

caggaggact gcttgaagcc aggagtttga gaccagcctg ggcaacatag tgagaccccg     5520

tgtctacaaa aagtaaacat ttatatatat attttttaaa gtggagcagt tcaatataga     5580

gtcttttttg aacaaacgtg aaatagatgt cttttttttt tttttgagat ggagttttca     5640

ctcttgttac ccaggctgga gtgcaatggc gtgatcttgg ctcaccagaa cctccgcctc     5700

ctgggttcaa acaattctcc tgcctcagcc tcccaggtag ctgggattac aggcatgcac     5760

caccaaaccc ggataatttt gtatttttag tagagatggg gtttcaccat gttggtcaag     5820

ctggtcttga actcccgacc tctgctgatc cgtatgcctc ggcctcccaa agtgctggga     5880

ttacatgcgt gagccaccgt gcccgacaat agatgtcttt taattttctg gaggaaaaag     5940

caaagcaaaa gaagcagtgg atattttaag actaaaaagg aaaacaaaaa aaggagatag     6000

agcaggccag acgtggtggc tcaacgtctg taatcccagc actttgggag gccgaggcag     6060

gtggatcacc tgaggtcagg agttcaagac cagcctgacc aacatggtga aaccctgttt     6120

caaaatacaa aaaattagct gggcgtggtg gcgggcacct gtaatcccag ctacttggga     6180

ggctgaggca ggagaatccc ttgaacccag gaggtggagg ttgcagtgag ccgagatcac     6240

gccattgcac tccagcctgg gcgacaagta aaaaactcca tctcaaaaaa aaaaaaggag     6300

atagagcaag gaacagtaag aaaatagttg ggtgcagtgg ctatgcggtg gcactatagg     6360

aggctgaggc gggcagatca cctgaggtca ggagttggag accagcctgg gcaacataga     6420

cccctatctc tacaaaaaat ttgaaatatg aaaaattagc caggtgtagt ggtgtgcgcc     6480

tgtggtacca gctactcaag aggcgaaggc agggaagatt gcttgagccc aggagtttga     6540

ggctatagtg agctgtgatc atgccactgc actccagcct gggcaatagt gtgagactct     6600

gtctcaaaag aaagaacatg gccaggcgtg gtggctcaca cctgtaatcc cagcactttg     6660

ggaggccgag gcagtcagat catgaggcca gtttgaaacc agcctggcca acatggtgaa     6720

accctgtctc tactaaaaat acaaaaatta gccaggcgtg gtggcatgcc cccgtaatcc     6780

cagctacttg ggggtctgag gcagaagaat tgcttgaaac cgggaggcag aggttgcagt     6840

gagccgagat cgtgtcattg cactctagtc tgggcgacag agcaagactc cgtcttggaa     6900

aaaaatttaa aaaaa                                                      6915


<210>  1170
<211>  400
<212>  PRT
<213>  Homo Sapiens

<400>  1170

Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 
1               5                   10                  15      


Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 
            20                  25                  30          


Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 
        35                  40                  45              


Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 
    50                  55                  60                  


Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 
65                  70                  75                  80  


Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 
                85                  90                  95      


Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 
            100                 105                 110         


Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 
        115                 120                 125             


Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 
    130                 135                 140                 


Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 
145                 150                 155                 160 


Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 
                165                 170                 175     


Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 
            180                 185                 190         


Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 
        195                 200                 205             


Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 
    210                 215                 220                 


Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 
225                 230                 235                 240 


Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 
                245                 250                 255     


Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 
            260                 265                 270         


Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 
        275                 280                 285             


Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 
    290                 295                 300                 


Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 
305                 310                 315                 320 


Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 
                325                 330                 335     


Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 
            340                 345                 350         


Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 
        355                 360                 365             


Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 
    370                 375                 380                 


Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 
385                 390                 395                 400 


<210>  1171
<211>  1901
<212>  DNA
<213>  Homo Sapiens

<400>  1171
cgcacttctg actcgagtcc ccgccgcgct tgtcgtcgcc gccgccggga tccgcagccc       60

cgcgccatgg agccggccgc gggcatccag cgccgcagct cccaggggcc caccgtcccg      120

ccgccgcccc ggggccacgc gccaccggct gccgcccccg gcccggcccc gctgagctcc      180

ccggtgcgcg agccgcccca gctggaggag gagcggcagg tgcggatcag cgagagcggc      240

cagttcagcg acgggctgga ggaccgaggc ttactagaaa gcagcacccg cctgaaacct      300

cacgaagccc agaactacag gaagaaggca ttgtgggtgt cctggttctc catcattgtc      360

accctggccc tcgcggtggc tgcctttact gtctccgtta tgaggtacag cgcctctgct      420

tttgggtttg catttgatgc catcctggac gtcctgtcat cggcgattgt cctgtggcgt      480

tacagcaacg cggccgctgt gcactctgcc catagggagt acatagcctg tgtcatcttg      540

ggggtgatat tccttctgtc atccatatgt atagtggtca aagccatcca tgacctctca      600

actaggctgc tcccagaagt ggacgatttc ctgttcagtg tctccatttt aagtgggatt      660

ctttgcagca tcctggccgt gttgaagttc atgctgggga aggttctgac cagtagagca      720

ctcataacag atgggtttaa ctccctcgtg ggtggcgtga tgggcttctc cattcttctg      780

agcgcggaag tgttcaagca tgactcggcg gtctggtacc tggacggcag cataggcgtt      840

ctgatcggcc tcaccatatt tgcctatggg gtcaaactcc tcatcgacat ggtgccgagg      900

gtgaggcaga cacgtcacta cgagatgttt gagtgaaggg ggccagcatc cgcatgagac      960

catcgagatg aggagtttcc acataggcaa agggtgccaa tatttaactg aacatctggt     1020

ttctttttgg aagttttctt tcacatggtt tgtcattaca agacaaggtc tgcccagcca     1080

ggtggatcta ccttgccccc atcacctgcc gcccccatca aacatgttgg gacaatgccc     1140

ataggaatgg acctccttcc ccgtctccag ctgggactgg cgttttttag tctctggagt     1200

atgatggttc tcatgggtag gatgagatct ttggcagaaa ggtcttcggt ggtgctctga     1260

gcctgcgctg cataggactg agcagaccca cctcctccag cttgggtggc cctgccactc     1320

ctggttccaa gtctctcctt tcctggcagg tcttaaggga agattgtacc cctcaccctt     1380

tacataccca gaatcatcag tatgtcactt cctaatttct atcagtgtat ctcattattt     1440

catactgttt tactaatcct aagtctaaac agatttgctc aaaaggagac cattctattt     1500

tttaaagtac ttagtgatac acgtataagc tttgcatgga cgaattaaat aagcacattg     1560

accttttctt gtacattcag aacctgaaca tccatgtgaa aactgggtcc atttttgaga     1620

gatgtgaaac tacagtttat ttgtaataaa taaatataat ctatccgtat atgcatatat     1680

ctatatgctg tgttaagtgg taatgggtac attacagtct gtgagagatg gatcgctccc     1740

tctgtaagga acaagacgtt ctcagctgat gtcacggtag gtttagattc tgtagagtgt     1800

tccccaaccc gcaccgttct gtacctctca caccactgct tgcccgggca gtagtggctg     1860

accaataaag acctttacct gttttgtatg gcaaaaaaaa a                         1901


<210>  1172
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  1172

Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 
1               5                   10                  15      


Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 
            20                  25                  30          


Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 
        35                  40                  45              


Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 
    50                  55                  60                  


Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 
65                  70                  75                  80  


Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 
                85                  90                  95      


Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 
            100                 105                 110         


Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 
        115                 120                 125             


Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 
    130                 135                 140                 


Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 
145                 150                 155                 160 


Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 
                165                 170                 175     


Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 
            180                 185                 190         


Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 
        195                 200                 205             


Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
    210                 215                 220                 


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
225                 230                 235                 240 


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
                245                 250                 255     


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
            260                 265                 270         


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
        275                 280                 285             


Glu 
    


<210>  1173
<211>  1816
<212>  DNA
<213>  Homo Sapiens

<400>  1173
gcctcttccc cctcccgcgc gcccgcccgc cgcctgccgc cgccgccgcc gccgccggag       60

ctctgtagta tggcatcgag gagaatggag accaaacctg tgataacctg tctcaaaacc      120

ctcctcatca tctactcctt cgtcttctgg atcactgggg tgatcctgct ggctgttgga      180

gtctggggca aacttactct gggcacctat atctccctta ttgccgagaa ctccacaaat      240

gctccctatg tgctcatcgg aactggcacc actattgttg tctttggcct gtttggatgc      300

tttgctacat gtcgtggtag cccatggatg ctgaaactgt atgccatgtt tctgtccctg      360

gtgttcctgg ctgagctcgt agctggcatt tcagggtttg tgtttcgtca tgagatcaag      420

gacaccttcc tgaggactta cacggacgct atgcagactt acaatggcaa tgatgagagg      480

agccgggcag tggaccatgt gcagcgcagc ctgagctgct gtggtgtgca gaactacacc      540

aactggagca ccagccccta cttcctggag catggcatcc cccccagctg ctgcatgaac      600

gaaactgatt gtaatcccca ggatctacac aatctgactg tggccgccac caaagttaac      660

cagaagggtt gttatgatct ggtaactagt ttcatggaga ctaacatggg aatcatcgct      720

ggagtggcgt ttggaatcgc attctcccag ttaattggca tgctgctggc ctgctgtctg      780

tcccggttca tcacggccaa tcagtatgag atggtgtaag gagaagtctt tcaagaatga      840

cggaataaga gacctgtttt aaaaaggaac tgcagcaatc tttgaaagac ttccaaagaa      900

tgttagagca cagtacataa tacacttgcc ctgctccctc tcccccttac cccacaacgt      960

gcaactgaca ctcccaccca gtctctgctc cacctttcag cccacgtcac gtgtagtgtc     1020

cattttgtga agccctgttg tgccacagag tgtagccagg tccccctgca gctagtccta     1080

gtgaacctca ccccgaggcc ctgcatgggc cagcccctcc atctgtactt ggtccaactg     1140

caactcatca tcggtgactg gttatcacac catcgctggc ccctttgggc cctgcatgta     1200

gtgtgggagg ctcctgttag ctcctcactg tggtaaatgc cacacacctt taagtagata     1260

agcagacgat agttatctgt tcttttgact taatctcatt tggtttgatt ttccctctac     1320

taaggctttc ctaccttctt caggctgcct aagacatgta acgaaacact tcaataattg     1380

tccatgagga gaaaaaaagc atgtgtcatg catgaaggaa actgaacttg aggtggcctc     1440

cttgcttgtt acatacctgg gtatgtgtag gcagtttagt gcatctttgc ctctcggttg     1500

aaacctgtat aaccctgtta caaagctgtg ttgttgcttc ttgtgaaggc catgatattt     1560

tgtttttccc caattaattg ctattgtgtt attttactac ttctctctgt attttttctt     1620

gcattgacat tatagacatt gaggacctca tccaaacaat ttaaaaatga gtgtgaaggg     1680

ggaacaagtc aaaatatttt taaaagatct tcaaaagtaa tgcctctgtc tagcatgcca     1740

acaagaatgc attgatattg tgaacatttg tgatatatgt attaataaat agagcaatta     1800

caagcaaaaa aaaaaa                                                     1816


<210>  1174
<211>  249
<212>  PRT
<213>  Homo Sapiens

<400>  1174

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15      


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30          


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45              


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80  


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110         


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125             


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140                 


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160 


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175     


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190         


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205             


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220                 


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240 


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245                 


<210>  1175
<211>  2433
<212>  DNA
<213>  Homo Sapiens

<400>  1175
atttcacttg gaggaaagag agaaggaagg aagctgagga cttagcaggg tatcactgga       60

caggccatgg ctccacggtc ccggcgacga aggcacaaga aacctccctc atcagtggct      120

cccatcatca tggccccaac cacaattgtg acccctgtgc ctctgacccc ctcaaaacct      180

ggccctagca ttgacacact tggcttcttc tccttggatg ataatgttcc tggcctatcg      240

cagctgatcc ttcaaaagct gaacatgaaa agctatgaag aatataagtt ggtggtagat      300

gggggtaccc ccgtatcagg ctttggattt cgatgtcctc aagaaatgtt ccagaggatg      360

gaagacacat ttcgattctg tgctcactgt agagcactcc ctagtgggct ttcagactcc      420

aaggttctcc ggcactgtaa gaggtgcaga aatgtctatt actgtggtcc agagtgccag      480

aagtcagact ggcccgcaca caggagggtt tgtcaagagc ttcgtcttgt ggctgtggac      540

cgtctcatgg aatggcttct ggtcacaggt gattttgttc taccctcagg accttggcca      600

tggccacctg aagctgtaca ggactgggac tcctggtttt ctatgaaggg gttacaccta      660

gatgctacat tggatgctgt gctagttagt catgctgtga ccaccttatg ggccagtgta      720

ggacggccaa ggccagaccc ggatgtcctg cagggatctt tgaagcggct gctgacagat      780

gtcctgtcac ggcccttgac tctaggccta ggacttaggg ccttggggat agatgttagg      840

aggactgggg gaagcacagt gcatgtggtt ggtgcttccc atgtggagac atttcttact      900

cgcccagggg actatgatga gcttggttac atgtttcctg ggcaccttgg actccgtgtg      960

gtcatggtgg gtgtagatgt agctactggc ttttcacaga gcacctcaac ttcacccctg     1020

gaacctggca caattcagct tagtgcccac aggggcctct accatgactt ctgggaggag     1080

caagtagaga ccgggcagac acaccatcca gatttggtgg cggcattcca tccaggtttt     1140

cattcctccc cagacttgat ggaggcttgg ctgcccaccc tgctgctact tcgtgactat     1200

aagattccta cattgattac tgtttacagc catcaggagt tggtatcctc tttgcagatt     1260

ctggtggaac tggatacaca catcactgcc tttgggtcta atcctttcat gtccctcaaa     1320

cctgaacagg tctattccag tcccaacaag cagccagtat actgcagtgc atactatatc     1380

atgtttcttg gaagctcctg tcagctggat aataggcaat tagaagagaa agtggacggc     1440

gggatttaaa tagatcataa ctggacatct ggaaaacggg gagtttgtga tgaaattacc     1500

ctgctaatgc caggttcttg caaactttga aaaacattat attctaaacc tcatttactg     1560

tttgggtaaa aattctaagc tgaatgagag tttctgtata acataactgg tttctttctt     1620

tttttgagat ggagtcttgc tctgttgccc aggctggagt gcagcggcat gatctcgact     1680

cactgcagcc tccgcctcct gggttcaagt ggttctcctg cctcagcctc cctagtagct     1740

gggattacag gtgcacacca ccacacctgg ctaatttttg tatttttagc agacagggtt     1800

tcaccatgtt ggccaggctc gtatcaaacc cttgacccca ggtgatctgc ctgcctcagc     1860

ctcccaaagt tctgggatta caggcatgag ccaccatgcc cagccaatgt aactggtttc     1920

taagagttta gccacagtag cttctagaga taggaaatta gatttagtgg gtgggaagag     1980

gccctgatgc tggtctttcc agagcttata gttgctaaca cttttctttg taaagaagtt     2040

taccttttga ctggaaccag atggcactga gaaaaagaat gagaaccacc ttattcttct     2100

gaaaaagact ttcttctcat ccagtaattt gggctaaaaa atggaaagat gttgatgact     2160

tgaagtgatg caagaatgga caagtcaggg aagtcattgg gaacatggat gaggttgtaa     2220

gcattggtac agtgtcctgt ttcctgactt ttttgagaga aatgtctact tttcctgttt     2280

tctcttgggg acttttgacc ctagagtagc cctggtgtta tattttagat atcccaagct     2340

atatcagact ttacctgaat atactggagt tacttattat cccccattct ataccccaat     2400

aaactcagtt tggggcttct taaaaaaaaa aaa                                  2433


<210>  1176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6 Heavy Chain CDR1

<400>  1176

Ser Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  1177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 1A8 Heavy Chain CDR1

<400>  1177

Ser Tyr Thr Phe Thr Asp Tyr Thr Met His 
1               5                   10  


<210>  1178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2Bl Heavy Chain CDR1

<400>  1178

Gly Phe Thr Phe Ser Arg Tyr Val Met Ser 
1               5                   10  


<210>  1179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2AI, Light Chain CDR 2

<400>  1179

Ser Ala Ser Tyr Arg Tyr Thr 
1               5

<210>  1180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2Al Heavy Chain CDR1

<400>  1180

Gly Tyr Asp Phe Asn Asn Asp Leu Ile Glu 
1               5                   10  


<210>  1181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2 Heavy Chain CDR1

<400>  1181

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  1182
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6 Heavy Chain CDR2

<400>  1182

Val Ile Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  1183
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 1A8 Heavy Chain CDR2

<400>  1183

Val Ile Asp Thr Tyr Tyr Gly Lys Thr Asn Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  1184
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2BI Heavy Chain CDR2

<400>  1184

Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  1185
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3G9 Heavy Chain CDR2

<400>  1185

Ser Ile Ser Ser Gly Gly Arg Met Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  1186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2AI Heavy Chain CDR2

<400>  1186

Val Ile Asn Pro Gly Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  1187
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2 Heavy Chain CDR2

<400>  1187

Val Ile Ser Pro Gly Ser Gly His Asn Tyr Asn Glu Lys Phe Lys Gly 
1               5                   10                  15      


<210>  1188
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6, Heavy Chain CDR3

<400>  1188

Gly Gly Leu Arg Arg Gly Asp Arg Pro Ser Leu Arg Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  1189
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 1A8, Heavy Chain CDR3

<400>  1189

Gly Gly Phe Arg Arg Gly Asp Arg Pro Ser Leu Arg Tyr Ala Met Asp 
1               5                   10                  15      


Ser 
    


<210>  1190
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2BI, Heavy Chain CDR3

<400>  1190

Gly Ala Ile Tyr Asp Gly Tyr Tyr Val Phe Ala Tyr 
1               5                   10          


<210>  1191
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3G9, Heavy Chain CDR3

<400>  1191

Gly Ser Ile Tyr Asp Gly Tyr Tyr Val Phe Pro Tyr 
1               5                   10          


<210>  1192
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2AI, Heavy Chain CDR3

<400>  1192

Ile Tyr Tyr Gly Pro His Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  1193
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2, Heavy Chain CDR3

<400>  1193

Ile Asp Tyr Ser Gly Pro Tyr Ala Val Asp Asp 
1               5                   10      


<210>  1194
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6, Light Chain CDR 1

<400>  1194

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met Tyr 
1               5                   10                  15  


<210>  1195
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 1A8, Light Chain CDR 1

<400>  1195

Arg Ala Ser Gln Ser Val Ser Ile Ser Thr Tyr Ser Tyr Ile His 
1               5                   10                  15  


<210>  1196
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2BI, Light Chain CDR 1

<400>  1196

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  1197
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3G9, Light Chain CDR 1

<400>  1197

Ser Ala Asn Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  1198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2AI, Light Chain CDR 1

<400>  1198

Lys Ala Ser Leu Asp Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  1199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2, Light Chain CDR 1

<400>  1199

Lys Ala Ser Gln Ala Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  1200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6, Light Chain CDR 2

<400>  1200

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  1201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2, Light Chain CDR 2

<400>  1201

Ser Ala Ser Tyr Gln Tyr Thr 
1               5           


<210>  1202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2BI and 3G9, Light Chain CDR 2

<400>  1202

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  1203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6, Light Chain CDR 3

<400>  1203

Gln His Asn Trp Glu Ile Pro Phe Thr 
1               5           


<210>  1204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 1A8, Light Chain CDR 3

<400>  1204

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5           


<210>  1205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2BI, Light Chain CDR 3

<400>  1205

His Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5           


<210>  1206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAntibody 3G9, Light Chain CDR 3

<400>  1206

His Gln Trp Ser Thr Tyr Pro Pro Thr 
1               5                   


<210>  1207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2AI, Light Chain CDR 3

<400>  1207

Gln Gln His Tyr Gly Ile Pro Trp Thr 
1               5                   


<210>  1208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 2G2, Light Chain CDR 3

<400>  1208

Gln His His Tyr Gly Val Pro Trp Thr 
1               5                   


<210>  1209
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 8G6, Heavy Chain CDR 3

<400>  1209

Gly Gly Leu Arg Arg Gly Asp Arg Pro Ser Leu Gln Tyr Ala Met Asp   
1               5                   10                  15 


Tyr


<210>  1210
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain sequence, humanized Antibody

<400>  1210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1               5                   10                  15


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45     


Ala Ser Ile Ser Ser Gly Gly Arg Met Tyr Tyr Pro Asp Thr Val Lys  
    50                  55                  60


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Aln Ser Leu Tyr Leu 
65                  70                  75                  80


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95


Arg Gly Ser Ile Tyr Asp Gly Tyr Tyr Val Phe Pro Tyr Trp Gly Gln 
            100                 105                 110


 
Gly Thr Leu Val Thr Val Ser Ser
        110                 120


<210>  1211
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized Antibody, light chain sequence

<400>  1211

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly   
1               5                   10                  15 


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
            20                  25                  30


Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
        35                  40                  45            


Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg
    50                  55                  60                


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser
                85                  90                  95


Thr Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys              
            100                 105                 110