
                                SEQUENCE LISTING

<110> Wang, Zhuozhi
      Winter, Ruth
      Murphy, John
      Bayer HealthCare

<120> PROTEASE-REGULATED ANTIBODIES
  

<130> 012973.00001

<140>
<141>

<150> US 61/617,837
<151> 2013-03-30

<160> 180

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 1
Ala His Pro Arg Ile Ile Ser Ala
 1               5

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 2
Ala Arg Thr Arg Ala Arg Arg Pro
 1               5

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 3
Ala Ser Ala Arg Thr Thr Gly Ser
 1               5

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 4
Ala Thr Pro Arg Gly Ala Ala Pro
 1               5

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 5
Ala Val Val Arg Thr Pro Pro Lys
 1               5

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 6
Glu Arg Thr Arg Ser Phe Gln Leu
 1               5

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 7
Phe Gly Leu Arg Phe Tyr Ala Tyr
 1               5

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 8
Phe Asn Pro Arg Thr Phe Gly Ser
 1               5

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 9
Phe Arg Pro Lys His Thr Arg Ile
 1               5

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 10
Phe Ser Ala Arg Gly His Arg Pro
 1               5

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 11
Gly Asp Ile Arg Gly Pro Arg Ile
 1               5

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 12
Gly Gly Val Arg Gly Pro Arg Val
 1               5

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 13
Gly Ser Phe Arg Ala Gly Leu Phe
 1               5

<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 14
His Lys Gly Arg Ser Ala Leu Val
 1               5

<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 15
Ile Ala Gly Arg Ser Leu Asn Pro
 1               5

<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 16
Ile Asp Gly Arg Ile Val Glu Gly
 1               5

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 17
Ile Glu Pro Arg Ser Phe Ser Gln
 1               5

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 18
Ile Lys Pro Arg Ile Val Gly Gly
 1               5

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 19
Ile Gln Ile Arg Ser Val Ala Lys
 1               5

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 20
Ile Gln Ile Arg Ser Val Ala Lys
 1               5

<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 21
Lys Asn Val Lys Ser Lys Ile Gly
 1               5

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 22
Lys Pro Lys Asp Ser Ser Val Asp
 1               5

<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 23
Leu Asp Pro Arg Ser Phe Leu Leu
 1               5

<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 24
Leu Gly Ile Arg Ser Phe Arg Asn
 1               5

<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 25
Leu Pro Ile Lys Thr Phe Arg Gly
 1               5

<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 26
Leu Arg Pro Arg Phe Lys Ile Ile
 1               5

<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 27
Leu Arg Pro Arg Ile Ile Gly Gly
 1               5

<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 28
Leu Ser Pro Arg Gly Val His Ile
 1               5

<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 29
Leu Ser Pro Arg Thr Phe His Pro
 1               5

<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 30
Met Thr Pro Arg Ser Glu Gly Ser
 1               5

<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 31
Met Thr Pro Arg Ser Gly Gly Ser
 1               5

<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 32
Met Thr Pro Arg Ser Arg Gly Ser
 1               5

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 33
Met Val Pro Arg Ala Val Tyr Leu
 1               5

<210> 34
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 34
Asn Val Pro Arg Ile Leu Ser Pro
 1               5

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 35
Pro Ala Pro Arg Gly Tyr Pro Gly
 1               5

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 36
Pro Asp Leu Arg Ser Cys Val Asn
 1               5

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 37
Pro Gly Pro Arg Gly Pro Pro Pro
 1               5

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 38
Pro Gly Ser Arg Ser Arg Thr Pro
 1               5

<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 39
Pro Gln Gly Arg Ile Val Gly Gly
 1               5

<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 40
Pro Gln Gly Arg Thr Thr Ala His
 1               5

<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 41
Pro Arg Ser Phe Leu Leu Arg Asn
 1               5

<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 42
Gln Ser Pro Arg Ser Phe Gln Lys
 1               5

<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 43
Gln Ser Pro Arg Ser Phe Gln Lys
 1               5

<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 44
Gln Tyr Leu Arg Val Pro Leu Val
 1               5

<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 45
Ser Glu Phe Arg Cys Leu Thr Pro
 1               5

<210> 46
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 46
Ser Ile Gly Arg Ala Ser Leu His
 1               5

<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 47
Ser Lys Gly Arg Ser Leu Ile Gly
 1               5

<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 48
Ser Arg Leu Arg Ala Tyr Leu Leu
 1               5

<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 49
Thr Cys Leu Arg Ser Thr Lys Phe
 1               5

<210> 50
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 50
Val Cys Leu Arg Ser Phe Gln Thr
 1               5

<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 51
Val Asp Pro Arg Leu Ile Asp Gly
 1               5

<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 52
Val Glu Val Lys Ser Glu Lys Leu
 1               5

<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 53
Val Ile Pro Lys Arg Ile Ser Pro
 1               5

<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 54
Val Ile Pro Arg Ser Gly Gly Ser
 1               5

<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 55
Val Asn Pro Arg Gly Ile Val Thr
 1               5

<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 56
Val Gln Pro Arg Ala Gln Lys Ile
 1               5

<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 57
Val Ser Pro Arg Ala Ser Ala Ser
 1               5

<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 58
Val Val Pro Arg Gly Val Asn Leu
 1               5

<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 59
Trp Tyr Leu Arg Ser Asn Asn Gly
 1               5

<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 60
Trp Tyr Leu Arg Ser Asn Thr Gly
 1               5

<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 61
Ala Phe Trp Lys Thr Asp Ala Ser
 1               5

<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 62
Ile Glu Gly Arg Thr Ala Thr Ser
 1               5

<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 63
Thr Ala Ala Arg Gln Ser Thr Asn
 1               5

<210> 64
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 64
Ile Asp Gly Arg Ile Val Glu Gly
 1               5

<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 65
Phe Asn Pro Arg Thr Phe Gly Ser
 1               5

<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 66
Arg Val Pro Lys Ser Phe Pro Phe
 1               5

<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 67
Pro Gln Leu Arg Met Lys Asn Asn
 1               5

<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 68
Ser Ser Trp Arg Leu Thr Ser Ser
 1               5

<210> 69
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 69
Leu Gly Ile Arg Ser Phe Arg Asn
 1               5

<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 70
Ala Met Ser Arg Met Ser Leu Ser
 1               5

<210> 71
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 71
Ala Asn Asn Arg Asp Asn Thr Tyr
 1               5

<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 72
Ala Asn Val Arg Arg Lys Arg Tyr
 1               5

<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 73
Ala Arg Gly Arg Ala Phe Pro Gln
 1               5

<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 74
Ala Thr Leu Lys Ser Arg Lys Met
 1               5

<210> 75
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 75
Ala Thr Gln Lys Lys Val Glu Arg
 1               5

<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 76
Ala Thr Trp Lys Thr Arg Trp Tyr
 1               5

<210> 77
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 77
Asp Val Gly Glu Tyr Asn Val Phe
 1               5

<210> 78
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 78
Glu Ala Arg Gly Ser Val Ile Leu
 1               5

<210> 79
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 79
Glu Ala Tyr Arg Arg Phe Tyr Gly
 1               5

<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 80
Glu Asp Asn Arg Asp Ser Ser Met
 1               5

<210> 81
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 81
Glu Thr Leu Lys Val Ile Asp Glu
 1               5

<210> 82
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 82
Phe Arg Ala Arg Ala Tyr Gly Phe
 1               5

<210> 83
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 83
Gly Glu Ala Arg Gly Ser Val Ile
 1               5

<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 84
Gly Gly Tyr Arg Ala Arg Pro Ala
 1               5

<210> 85
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 85
Gly Ile Leu Lys Glu Asn Ala Ala
 1               5

<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 86
Gly Pro Lys Arg Gly Thr Glu Pro
 1               5

<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 87
Ile Ile Arg Arg Ser Ile Gln Ile
 1               5

<210> 88
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 88
Ile Thr Phe Arg Met Asn Val Ala
 1               5

<210> 89
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 89
Lys His Ser Lys Arg His Ile His
 1               5

<210> 90
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 90
Lys Lys Asp Arg Ala Arg Gln Glu
 1               5

<210> 91
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 91
Lys Lys Pro Arg Cys Gly Val Pro
 1               5

<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 92
Lys Gln Val Lys Asp Asn Glu Asn
 1               5

<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 93
Leu Asp Pro Arg Ser Phe Leu Leu
 1               5

<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 94
Leu Pro Pro Lys Ser Gln Pro Pro
 1               5

<210> 95
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 95
Leu Ser Phe Arg Ala Arg Ala Tyr
 1               5

<210> 96
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 96
Met Ser Met Arg Val Arg Arg His
 1               5

<210> 97
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 97
Asn Ser Gly Arg Ala Val Thr Tyr
 1               5

<210> 98
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 98
Pro Ala Pro Arg Gly Tyr Pro Gly
 1               5

<210> 99
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 99
Pro Glu Ala Lys Ala Ser Cys Tyr
 1               5

<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 100
Pro Glu Ser Lys Ala Thr Asn Ala
 1               5

<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 101
Pro Gly Pro Lys Arg Gly Thr Glu
 1               5

<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 102
Pro Lys Ala Lys Ser His Ala Pro
 1               5

<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 103
Pro Leu Asp Lys Lys Arg Glu Glu
 1               5

<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 104
Pro Leu Gln Lys Gln Leu Pro Ala
 1               5

<210> 105
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 105
Pro Gln Phe Arg Ile Lys Gly Gly
 1               5

<210> 106
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 106
Pro Gln Leu Arg Leu Pro His Thr
 1               5

<210> 107
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 107
Pro Gln Leu Arg Arg Gly Trp Arg
 1               5

<210> 108
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 108
Pro Gln Ser Arg Ser Val Pro Pro
 1               5

<210> 109
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 109
Pro Arg Phe Lys Ile Ile Gly Gly
 1               5

<210> 110
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 110
Pro Tyr Leu Lys Val Phe Asn Pro
 1               5

<210> 111
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 111
Gln Lys Ser Arg Asn Gly Leu Arg
 1               5

<210> 112
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 112
Gln Leu Ile Lys Ala Ile Gln Leu
 1               5

<210> 113
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 113
Gln Arg Tyr Lys Val Asp Tyr Glu
 1               5

<210> 114
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 114
Arg Ala Gln Arg Ser Ala Gly Ala
 1               5

<210> 115
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 115
Arg Gly Pro Arg Val Val Glu Arg
 1               5

<210> 116
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 116
Arg Pro Ala Lys Ala Ala Ala Thr
 1               5

<210> 117
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 117
Arg Arg Lys Arg Tyr Ala Ile Gln
 1               5

<210> 118
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 118
Arg Ser Ser Lys Gly Arg Ser Leu
 1               5

<210> 119
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 119
Arg Ser Thr Arg Phe Ala Ala Thr
 1               5

<210> 120
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 120
Ser Cys Asp Lys Thr His Thr Cys
 1               5

<210> 121
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 121
Ser Ile Asn Lys Ser Ser Pro Leu
 1               5

<210> 122
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 122
Ser Gln Pro Pro Glu Lys Thr Glu
 1               5

<210> 123
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 123
Ser Gln Arg Lys His Ser Lys Arg
 1               5

<210> 124
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 124
Ser Ser Met Lys Leu Ser Phe Arg
 1               5

<210> 125
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 125
Thr Glu Pro Lys Val Lys Leu Pro
 1               5

<210> 126
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 126
Thr Glu Tyr Arg Leu Val Ser Ile
 1               5

<210> 127
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 127
Thr His Glu Lys Gly Arg Gln Ser
 1               5

<210> 128
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 128
Thr Tyr Ser Lys Ala Ser Thr Pro
 1               5

<210> 129
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 129
Thr Tyr Ser Arg Ser Arg Tyr Leu
 1               5

<210> 130
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 130
Val Ser Asn Lys Val Ser Met Ser
 1               5

<210> 131
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fab-1 light chain

<400> 131
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
        35                  40                  45
Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Leu
            100                 105                 110
Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gly Gln Pro Lys Ala Ala
        115                 120                 125
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
    130                 135                 140
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
145                 150                 155                 160
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
                165                 170                 175
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
            180                 185                 190
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
        195                 200                 205
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
    210                 215                 220
Thr Glu Cys Ser
225

<210> 132
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site and linker

<400> 132
Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 133
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fab-1 heavy chain

<400> 133
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser
        115                 120                 125
Gly Gly Gly Gly Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
    130                 135                 140
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys
145                 150                 155                 160
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                165                 170                 175
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
            180                 185                 190
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn
        195                 200                 205
Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn
    210                 215                 220
Thr Lys Val Asp Lys Thr Val Asp Tyr Lys Asp Asp Asp Asp Lys His
225                 230                 235                 240
His His His His His
                245

<210> 134
<211> 1590
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence encoding Fab-1 

<400> 134
ggtctcacat gaaaaaaacc gctatcgcta tcgccgtcgc actggctggc ttcgcaaccg      60
tggcacaggc atcctatgaa ctgacccaac cgccgagtgt ctccgtgtca ccgggtcaga     120
cggcacgtat tacctgcagc ggtgataacc tgccgaaata ttacgcgcat tggtatcagc     180
aaaaaccggg ccaagccccg gtggttgtca tcttttatga cgttaatcgt ccgtccggta     240
tcccggaacg cttctcgggc agcaactctg gtaatacggc aaccctgacg atcagcggca     300
cccaggcaat ggatgaagct gactattact gtcaagcatg gtggagctct acgccggtgt     360
ttggcggtgg cacgaaactg accgtgctgg gtggcggtgg ctctctggtt ccgcgtggct     420
ccggtggcgg tggctcaggc cagccgaaag cagcaccgag tgttaccctg tttccgccga     480
gttccgaaga actgcaagca aacaaagcta ccctggtgtg cctgattagc gatttctatc     540
cgggcgcagt tacggtcgcg tggaaagccg actcatcgcc ggtgaaagct ggtgttgaaa     600
ccacgacccc gtcaaaacag tcgaacaata aatatgcagc tagctcttac ctgtctctga     660
ccccggaaca gtggaaaagt catcgcagtt actcctgtca agttacgcac gaaggctcca     720
cggtcgaaaa aaccgtggca ccgacggaat gctcatgata agcatgcgta ggagaaaata     780
aaatgaaaca gtctaccatc gcactggcac tgctgccgct gctgtttacg ccggtgacca     840
aagcagaagt tcagctggtc gaaagtggtg gcggtctggt tcaaccgggc ggttcactgc     900
gtctgtcgtg cgcagcaagc ggttttacct tcagttccta tggtatggat tgggtccgtc     960
aggcaccggg taaaggtctg gaatgggtgt catcgattcg tggcagccgc ggttctacct    1020
attacgccga ttcagttaaa ggccgtttta ccatctctcg cgacaacagt aaaaatacgc    1080
tgtatctgca gatgaacagc ctgcgcgcgg aagataccgc cgtgtattac tgtgcccgtc    1140
tgtatcgcta ctggttcgac tactggggcc agggtacgct ggtgaccgtt agctctggcg    1200
gtggcggttc gctggtcccg cgtggcagcg gcggtggcgg ttcagcgagc accaaaggtc    1260
cgagcgtgtt tccgctggca ccgtgcagcc gctctaccag tgaatccacg gcagctctgg    1320
gttgtctggt gaaagattat tttccggaac cggtcaccgt gagttggaac tccggcgcac    1380
tgacctcggg tgttcatacg ttcccggctg tcctgcagag ttccggcctg tatagcctgt    1440
catcggtggt taccgttccg agctctaatt tcggcaccca aacgtacacc tgcaacgtcg    1500
atcacaaacc gtctaatacc aaagttgaca aaacggttga ttacaaagac gacgacgaca    1560
aacaccacca ccaccaccat tgataagctt                                     1590

<210> 135
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fab-2 light chain

<400> 135
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
        35                  40                  45
Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Leu Val Pro Arg Gly Ser
            100                 105                 110
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
        115                 120                 125
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
    130                 135                 140
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
145                 150                 155                 160
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
                165                 170                 175
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
            180                 185                 190
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
        195                 200                 205
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215

<210> 136
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fab-2 Heavy Chain
<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Leu Val Pro Arg Gly Ser Ala Ser Thr Lys Gly
        115                 120                 125
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190
Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val
        195                 200                 205
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Asp Tyr Lys
    210                 215                 220
Asp Asp Asp Asp Lys His His His His His His
225                 230                 235

<210> 137
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease cleavage site

<400> 137
Leu Val Pro Arg Gly Ser
 1               5

<210> 138
<211> 1530
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fab-2 coding sequence

<400> 138
ggtctcacat gaaaaaaacg gctatcgcaa tcgctgtggc actggcaggc ttcgcaacgg      60
tcgcgcaggc atcctatgaa ctgacgcaac cgccgagtgt ctccgtgtca ccgggtcaga     120
cggcacgtat tacctgctct ggtgataacc tgccgaaata ttacgcgcat tggtatcagc     180
aaaaaccggg ccaagccccg gtggttgtca tcttttatga cgttaatcgt ccgtcgggta     240
tcccggaacg cttctcgggc agcaactctg gtaatacggc caccctgacg atctcaggca     300
cccaggcaat ggatgaagct gactattact gccaagcatg gtggagctct acgccggtgt     360
ttggcggtgg cacgaaactg accgttctgc tggtcccgcg tggctccggt cagccgaaag     420
cagccccgtc agttaccctg tttccgccga gttccgaaga actgcaagca aacaaagcta     480
ccctggtgtg tctgattagc gatttctatc cgggcgcagt tacggtcgcg tggaaagccg     540
actcatcgcc ggtcaaagct ggtgtggaaa ccaccacccc gtcaaaacag tcgaacaata     600
aatatgcagc tagctcttac ctgtcgctga ccccggaaca gtggaaaagc catcgcagtt     660
actcctgcca agttacgcac gaaggctcta cggttgaaaa aaccgtcgca ccgacggaat     720
gcagttgata agcatgcgta ggagaaaata aaatgaaaca gagcaccatc gcactggcac     780
tgctgccgct gctgtttacg ccggtcacca aagcagaagt gcagctggtt gaatctggtg     840
gcggtctggt gcaaccgggc ggttcactgc gtctgtcgtg tgcggccagc ggctttacct     900
tcagttccta tggtatggat tgggtccgtc aggcaccggg taaaggtctg gaatgggtgt     960
catcgattcg tggcagccgc ggttctacct attacgccga ttccgttaaa ggccgtttca    1020
ccatctctcg cgacaacagt aaaaatacgc tgtatctgca gatgaacagt ctgcgcgcgg    1080
aagataccgc cgtgtattac tgcgcccgtc tgtatcgcta ctggtttgac tactggggcc    1140
agggtacgct ggtgaccgtt agctctctgg ttccgcgtgg ctcagcgagc accaaaggtc    1200
cgagtgtctt cccgctggca ccgtgcagcc gctctaccag tgaatccacg gcagctctgg    1260
gttgtctggt gaaagattat tttccggaac cggtcaccgt gagttggaac tccggcgcac    1320
tgacctccgg tgtgcatacg ttcccggctg ttctgcagag ttccggcctg tattcactgt    1380
catcggtggt taccgtgccg agctctaatt ttggcaccca aacgtacacc tgtaacgttg    1440
atcacaaacc gagcaatacc aaagttgaca aaaccgttga ctacaaagac gacgacgaca    1500
aacaccacca ccaccaccac tgataagctt                                     1530

<210> 139
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2-linker 1, Light chain amino acid sequence

<400> 139
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
        35                  40                  45
Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Leu
            100                 105                 110
Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gly Gln Pro Lys Ala Ala
        115                 120                 125
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
    130                 135                 140
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
145                 150                 155                 160
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
                165                 170                 175
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
            180                 185                 190
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
        195                 200                 205
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
    210                 215                 220
Thr Glu Cys Ser
225

<210> 140
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2-linker1, heavy chain amino acid sequence

<400> 140
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Leu Val Pro Arg
        115                 120                 125
Gly Ser Gly Gly Gly Gly Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
    130                 135                 140
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys
145                 150                 155                 160
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
                165                 170                 175
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
            180                 185                 190
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn
        195                 200                 205
Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn
    210                 215                 220
Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
225                 230                 235                 240
Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn
        275                 280                 285
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300
Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320
Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335
Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
            340                 345                 350
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
        355                 360                 365
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
    450                 455

<210> 141
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2-linker 1, Light chain DNA sequence

<400> 141
tcctacgagc tgacccagcc cccttccgtg tccgtgtctc ctggccagac cgcccggatc      60
acctgttccg gcgacaacct gcccaagtac tacgcccact ggtatcagca gaagcccggc     120
caggcccccg tggtggtcat cttctacgac gtgaaccggc cctccggcat ccccgagaga     180
ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccatg     240
gacgaggccg actactactg ccaggcttgg tggtcctcca cccccgtgtt tggcggcgga     300
acaaagttaa ccgtgctggg cggtggagga tcactggttc cgcgtggctc tggcggtgga     360
ggatcaggcc agcccaaggc cgctccttcc gtgaccctgt tccccccatc ctccgaggaa     420
ctgcaggcca acaaggccac cctggtctgc ctgatctccg acttctaccc tggcgccgtg     480
accgtggcct ggaaggccga cagctctcct gtgaaggccg gcgtggaaac caccaccccc     540
tccaagcagt ccaacaacaa atacgccgcc tcctcctacc tgtccctgac ccccgagcag     600
tggaagtccc accggtccta cagctgccag gtcacacacg agggctccac cgtggaaaag     660
acagtggccc ccaccgagtg ctct                                            684

<210> 142
<211> 1374
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2-linker 1, Heavy chain DNA sequence
      
<400> 142
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggatc tctgagactg      60
tcctgcgccg cctccggctt caccttctcc agctacggca tggactgggt ccgacaggcc     120
cctggcaagg gcctggaatg ggtgtcctcc atccggggct ctcggggctc cacctactac     180
gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac     240
ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc cagactgtac     300
cggtattggt tcgactactg gggccagggc accctggtca ccgtcagctc agcttctggc     360
ggaggcggct ctctggtgcc tagaggatct ggcggcggag gctccaccaa gggcccttcc     420
gtgttccctc tggccccttg ctcccggtcc acctccgagt ctaccgccgc tctgggctgc     480
ctggtcaagg attacttccc cgagcccgtg accgtgtcct ggaactctgg cgccctgacc     540
agcggcgtgc acaccttccc tgccgtgctg cagtcctccg gcctgtactc cctgtcctcc     600
gtcgtgacag tgccctcctc caacttcggc acccagacct acacctgtaa cgtggaccac     660
aagccctcca acaccaaggt ggacaagacc gtggaacgga agtgctgcgt ggaatgcccc     720
ccctgtcctg cacctcctgt ggctggacct agcgtgttcc tgttcccccc aaagcccaag     780
gacaccctga tgatctcccg gacccccgaa gtgacctgcg tggtggtgga cgtgtcccac     840
gaggaccccg aggtgcagtt caattggtac gtggacggcg tggaagtgca caacgccaag     900
accaagccca gagaggaaca gttcaactcc accttccggg tggtgtccgt gctgaccgtg     960
gtgcaccagg actggctgaa cggcaaagag tacaagtgca aggtctccaa caagggcctg    1020
cctgccccca tcgaaaagac catcagcaag accaagggcc agccccgcga gccccaggtg    1080
tacacactgc cacctagccg ggaagagatg accaagaacc aggtgtccct gacctgtctg    1140
gtcaagggct tctacccatc cgacattgcc gtggaatggg agtccaacgg ccagcccgag    1200
aacaactaca agaccacccc ccccatgctg gactccgacg gctcattctt cctgtactcc    1260
aagctgacag tggacaagtc ccggtggcag cagggcaacg tgttctcctg ctccgtgatg    1320
cacgaggccc tgcacaacca ctacacccag aagtccctgt ccctgagccc cggc          1374

<210> 143
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2-linker 2, Light chain amino acid sequence
      
<400> 143
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
        35                  40                  45
Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Leu Val Pro Arg Gly Ser
            100                 105                 110
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
        115                 120                 125
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
    130                 135                 140
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
145                 150                 155                 160
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
                165                 170                 175
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
            180                 185                 190
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
        195                 200                 205
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215

<210> 144
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2-linker 2, heavy chain amino acid sequence
      
<400> 144
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Ala Ser Leu Val Pro Arg Gly Ser Thr Lys Gly
        115                 120                 125
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190
Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val
        195                 200                 205
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys
    210                 215                 220
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335
Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445

<210> 145
<211> 654
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2-linker 2, Light chain DNA sequence
      
<400> 145
tcctacgagc tgacccagcc cccttccgtg tccgtgtctc ctggccagac cgcccggatc      60
acctgttccg gcgacaacct gcccaagtac tacgcccact ggtatcagca gaagcccggc     120
caggcccccg tggtggtcat cttctacgac gtgaaccggc cctccggcat ccccgagaga     180
ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccatg     240
gacgaggccg actactactg ccaggcttgg tggtcctcca cccccgtgtt tggcggcgga     300
acaaagttaa ccgtgctgct ggttccgcgt ggctctggcc agcccaaggc cgctccttcc     360
gtgaccctgt tccccccatc ctccgaggaa ctgcaggcca acaaggccac cctggtctgc     420
ctgatctccg acttctaccc tggcgccgtg accgtggcct ggaaggccga cagctctcct     480
gtgaaggccg gcgtggaaac caccaccccc tccaagcagt ccaacaacaa atacgccgcc     540
tcctcctacc tgtccctgac ccccgagcag tggaagtccc accggtccta cagctgccag     600
gtcacacacg agggctccac cgtggaaaag acagtggccc ccaccgagtg ctct           654

<210> 146
<211> 1344
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG2-linker 2, Heavy chain DNA sequence
      
<400> 146
gaggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggcggatc tctgagactg      60
tcctgcgccg cctccggctt caccttctcc agctacggca tggactgggt ccgacaggcc     120
cctggcaagg gcctggaatg ggtgtcctcc atccggggct ctcggggctc cacctactac     180
gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac     240
ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc cagactgtac     300
cggtattggt tcgactactg gggccagggc accctggtca ccgtcagctc agcttctctg     360
gtgcctagag gatctaccaa gggcccttcc gtgttccctc tggccccttg ctcccggtcc     420
acctccgagt ctaccgccgc tctgggctgc ctggtcaagg attacttccc cgagcccgtg     480
accgtgtcct ggaactctgg cgccctgacc agcggcgtgc acaccttccc tgccgtgctg     540
cagtcctccg gcctgtactc cctgtcctcc gtcgtgacag tgccctcctc caacttcggc     600
acccagacct acacctgtaa cgtggaccac aagccctcca acaccaaggt ggacaagacc     660
gtggaacgga agtgctgcgt ggaatgcccc ccctgtcctg cacctcctgt ggctggacct     720
agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatctcccg gacccccgaa     780
gtgacctgcg tggtggtgga cgtgtcccac gaggaccccg aggtgcagtt caattggtac     840
gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaactcc     900
accttccggg tggtgtccgt gctgaccgtg gtgcaccagg actggctgaa cggcaaagag     960
tacaagtgca aggtctccaa caagggcctg cctgccccca tcgaaaagac catcagcaag    1020
accaagggcc agccccgcga gccccaggtg tacacactgc cacctagccg ggaagagatg    1080
accaagaacc aggtgtccct gacctgtctg gtcaagggct tctacccatc cgacattgcc    1140
gtggaatggg agtccaacgg ccagcccgag aacaactaca agaccacccc ccccatgctg    1200
gactccgacg gctcattctt cctgtactcc aagctgacag tggacaagtc ccggtggcag    1260
cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag    1320
aagtccctgt ccctgagccc cggc                                           1344

<210> 147
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Thrombin cleavage site
    
<221> VARIANT        
<222> (1)...(2)
<223> Xaa = hydrophobic amino acid

<221> VARIANT        
<222> (5)...(6)
<223> Xaa = nonacidic amino acid 

<400> 147
Xaa Xaa Pro Arg Xaa Xaa
 1               5

<210> 148
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Factor Xa cleavage site     
      

<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Glu or Asp

<400> 148
Ile Xaa Gly Arg
 1

<210> 149
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 149
Gly Gly Gly Gly Ser
 1               5

<210> 150
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acids 95-152 of SEQ ID NO:133
      
<400> 150
Tyr Cys Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly
 1               5                  10                  15
Thr Leu Val Thr Val Ser Ser Ala Ser Gly Ser Gly Gly Gly Leu Val
            20                  25                  30
Pro Arg Gly Ser Gly Gly Gly Gly Ser Thr Lys Gly Pro Ser Val Phe
        35                  40                  45
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser
    50                  55

<210> 151
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 151
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg
 1               5                  10                  15

<210> 152
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 152
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg
 1               5                  10                  15
Val 
<210> 153
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 153
Ala Lys Thr Thr Pro Lys Leu Gly Gly
 1               5

<210> 154
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 154
Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly
 1               5                  10

<210> 155
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 155
Ser Ala Lys Thr Thr Pro
 1               5

<210> 156
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 156
Arg Ala Asp Ala Ala Pro
 1               5

<210> 157
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 157
Arg Ala Asp Ala Ala Pro Thr Val Ser
 1               5

<210> 158
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 158
Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser
 1               5                  10

<210> 159
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 159
Arg Ala Asp Ala Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25

<210> 160
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 160
Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala
 1               5                  10                  15
Arg Val 
<210> 161
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 161
Ala Asp Ala Ala Pro
 1               5

<210> 162
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 162
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
 1               5                  10

<210> 163
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 163
Thr Val Ala Ala Pro
 1               5

<210> 164
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 164
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
 1               5                  10

<210> 165
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 165
Gln Pro Lys Ala Ala Pro
 1               5

<210> 166
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 166
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro
 1               5                  10

<210> 167
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 167
Ala Lys Thr Thr Pro Pro
 1               5

<210> 168
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 168
Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro
 1               5                  10

<210> 169
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker
      
<400> 169
Ala Lys Thr Thr Ala Pro
 1               5

<210> 170
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 170
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro
 1               5                  10

<210> 171
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 171
Ala Ser Thr Lys Gly Pro
 1               5

<210> 172
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 172
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
 1               5                  10

<210> 173
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 173
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15

<210> 174
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 174
Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser
 1               5                  10                  15

<210> 175
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 175
Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser
 1               5                  10                  15

<210> 176
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid linker

<400> 176
Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser
 1               5                  10                  15

<210> 177
<211> 442
<212> PRT
<213> Homo sapiens

<400> 177
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
        115                 120                 125
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys
    130                 135                 140
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
145                 150                 155                 160
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
                165                 170                 175
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn
            180                 185                 190
Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn
        195                 200                 205
Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
    210                 215                 220
Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro
225                 230                 235                 240
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                245                 250                 255
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn
            260                 265                 270
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        275                 280                 285
Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val
    290                 295                 300
Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
305                 310                 315                 320
Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
                325                 330                 335
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
            340                 345                 350
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        355                 360                 365
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    370                 375                 380
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
385                 390                 395                 400
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                405                 410                 415
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            420                 425                 430
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440

<210> 178
<211> 212
<212> PRT
<213> Homo sapiens

<400> 178
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Pro Lys Tyr Tyr Ala
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Phe
        35                  40                  45
Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp Ser Ser Thr Pro Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
            100                 105                 110
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205
Thr Glu Cys Ser
    210

<210> 179
<211> 239
<212> PRT
<213> Artificial Sequence

<220> 
<223> protease-cleavable anti-TFPI scFv antibody
 
<400> 179
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Arg Gly Ser Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Leu Tyr Arg Tyr Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser
        115                 120                 125
Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser
    130                 135                 140
Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu
145                 150                 155                 160
Pro Lys Tyr Tyr Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
                165                 170                 175
Val Val Val Ile Phe Tyr Asp Val Asn Arg Pro Ser Gly Ile Pro Glu
            180                 185                 190
Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser
        195                 200                 205
Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Trp
    210                 215                 220
Ser Ser Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
225                 230                 235

<210> 180
<211> 717
<212> DNA
<213> Artificial Sequence

<220> 
<223> protease-cleavable anti-TFPI scFv antibody coding
      sequence
 
<400> 180
gaagttcagc tggtcgaaag tggtggcggt ctggttcaac cgggcggttc actgcgtctg      60
tcgtgcgcag caagcggttt taccttcagt tcctatggta tggattgggt ccgtcaggca     120
ccgggtaaag gtctggaatg ggtgtcatcg attcgtggca gccgcggttc tacctattac     180
gccgattcag ttaaaggccg ttttaccatc tctcgcgaca acagtaaaaa tacgctgtat     240
ctgcagatga acagcctgcg cgcggaagat accgccgtgt attactgtgc ccgtctgtat     300
cgctactggt tcgactactg gggccagggt acgctggtga ccgttagctc tggtggcggt     360
ggctctctgg ttccgcgtgg ctccggtggc ggtggctcat cctatgaact gacccaaccg     420
ccgagtgtct ccgtgtcacc gggtcagacg gcacgtatta cctgcagcgg tgataacctg     480
ccgaaatatt acgcgcattg gtatcagcaa aaaccgggcc aagccccggt ggttgtcatc     540
ttttatgacg ttaatcgtcc gtccggtatc ccggaacgct tctcgggcag caactctggt     600
aatacggcaa ccctgacgat cagcggcacc caggcaatgg atgaagctga ctattactgt     660
caagcatggt ggagctctac gccggtgttt ggcggtggca cgaaactgac cgtgctg        717
