                         SEQUENCE LISTING

<110>  OTT, MELANIE
       VERDIN, ERIC  M.
       ZHOU, MING-MING
 
<120>  COMPOSITIONS AND METHODS FOR REACTIVATING LATENT IMMUNODEFICIENCY
        VIRUS

<130>  GLAD-403WO

<150>  US 61/616,764
<151>  2012-03-28

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  549
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Lys 
545                 


<210>  2
<211>  2442
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  3
<211>  832
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Ser Glu Ala Gly Gly Ala Gly Pro Gly Gly Cys Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Pro Gly Ala Leu Pro Pro Gln Pro Ala Ala Leu 
            20                  25                  30          


Pro Pro Ala Pro Pro Gln Gly Ser Pro Cys Ala Ala Ala Ala Gly Gly 
        35                  40                  45              


Ser Gly Ala Cys Gly Pro Ala Thr Ala Val Ala Ala Ala Gly Thr Ala 
    50                  55                  60                  


Glu Gly Pro Gly Gly Gly Gly Ser Ala Arg Ile Ala Val Lys Lys Ala 
65                  70                  75                  80  


Gln Leu Arg Ser Ala Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val 
                85                  90                  95      


Tyr Ser Ala Cys Lys Ala Glu Glu Ser Cys Lys Cys Asn Gly Trp Lys 
            100                 105                 110         


Asn Pro Asn Pro Ser Pro Thr Pro Pro Arg Ala Asp Leu Gln Gln Ile 
        115                 120                 125             


Ile Val Ser Leu Thr Glu Ser Cys Arg Ser Cys Ser His Ala Leu Ala 
    130                 135                 140                 


Ala His Val Ser His Leu Glu Asn Val Ser Glu Glu Glu Met Asn Arg 
145                 150                 155                 160 


Leu Leu Gly Ile Val Leu Asp Val Glu Tyr Leu Phe Thr Cys Val His 
                165                 170                 175     


Lys Glu Glu Asp Ala Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys 
            180                 185                 190         


Leu Leu Arg Lys Ser Ile Leu Gln Arg Gly Lys Pro Val Val Glu Gly 
        195                 200                 205             


Ser Leu Glu Lys Lys Pro Pro Phe Glu Lys Pro Ser Ile Glu Gln Gly 
    210                 215                 220                 


Val Asn Asn Phe Val Gln Tyr Lys Phe Ser His Leu Pro Ala Lys Glu 
225                 230                 235                 240 


Arg Gln Thr Ile Val Glu Leu Ala Lys Met Phe Leu Asn Arg Ile Asn 
                245                 250                 255     


Tyr Trp His Leu Glu Ala Pro Ser Gln Arg Arg Leu Arg Ser Pro Asn 
            260                 265                 270         


Asp Asp Ile Ser Gly Tyr Lys Glu Asn Tyr Thr Arg Trp Leu Cys Tyr 
        275                 280                 285             


Cys Asn Val Pro Gln Phe Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr 
    290                 295                 300                 


Gln Val Phe Gly Arg Thr Leu Leu Arg Ser Val Phe Thr Val Met Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Gln Ala Arg Gln Glu Lys Asp Lys Leu Pro Leu 
                325                 330                 335     


Glu Lys Arg Thr Leu Ile Leu Thr His Phe Pro Lys Phe Leu Ser Met 
            340                 345                 350         


Leu Glu Glu Glu Val Tyr Ser Gln Asn Ser Pro Ile Trp Asp Gln Asp 
        355                 360                 365             


Phe Leu Ser Ala Ser Ser Arg Thr Ser Gln Leu Gly Ile Gln Thr Val 
    370                 375                 380                 


Ile Asn Pro Pro Pro Val Ala Gly Thr Ile Ser Tyr Asn Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Leu Glu Gln Pro Asn Ala Gly Ser Ser Ser Pro Ala Cys Lys 
                405                 410                 415     


Ala Ser Ser Gly Leu Glu Ala Asn Pro Gly Glu Lys Arg Lys Met Thr 
            420                 425                 430         


Asp Ser His Val Leu Glu Glu Ala Lys Lys Pro Arg Val Met Gly Asp 
        435                 440                 445             


Ile Pro Met Glu Leu Ile Asn Glu Val Met Ser Thr Ile Thr Asp Pro 
    450                 455                 460                 


Ala Ala Met Leu Gly Pro Glu Thr Asn Phe Leu Ser Ala His Ser Ala 
465                 470                 475                 480 


Arg Asp Glu Ala Ala Arg Leu Glu Glu Arg Arg Gly Val Ile Glu Phe 
                485                 490                 495     


His Val Val Gly Asn Ser Leu Asn Gln Lys Pro Asn Lys Lys Ile Leu 
            500                 505                 510         


Met Trp Leu Val Gly Leu Gln Asn Val Phe Ser His Gln Leu Pro Arg 
        515                 520                 525             


Met Pro Lys Glu Tyr Ile Thr Arg Leu Val Phe Asp Pro Lys His Lys 
    530                 535                 540                 


Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile Gly Gly Ile Cys Phe 
545                 550                 555                 560 


Arg Met Phe Pro Ser Gln Gly Phe Thr Glu Ile Val Phe Cys Ala Val 
                565                 570                 575     


Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr His Leu Met Asn His 
            580                 585                 590         


Leu Lys Glu Tyr His Ile Lys His Asp Ile Leu Asn Phe Leu Thr Tyr 
        595                 600                 605             


Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys Gln Gly Phe Ser Lys 
    610                 615                 620                 


Glu Ile Lys Ile Pro Lys Thr Lys Tyr Val Gly Tyr Ile Lys Asp Tyr 
625                 630                 635                 640 


Glu Gly Ala Thr Leu Met Gly Cys Glu Leu Asn Pro Arg Ile Pro Tyr 
                645                 650                 655     


Thr Glu Phe Ser Val Ile Ile Lys Lys Gln Lys Glu Ile Ile Lys Lys 
            660                 665                 670         


Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys Val Tyr Pro Gly Leu 
        675                 680                 685             


Ser Cys Phe Lys Asp Gly Val Arg Gln Ile Pro Ile Glu Ser Ile Pro 
    690                 695                 700                 


Gly Ile Arg Glu Thr Gly Trp Lys Pro Ser Gly Lys Glu Lys Ser Lys 
705                 710                 715                 720 


Glu Pro Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu 
                725                 730                 735     


Gln Gln Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val 
            740                 745                 750         


Lys Arg Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met 
        755                 760                 765             


Asp Leu Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser 
    770                 775                 780                 


Lys Lys Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys 
785                 790                 795                 800 


Glu Tyr Asn Ala Ala Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu 
                805                 810                 815     


Glu Lys Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys 
            820                 825                 830         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Arg Gln Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys Thr 
1               5                   10                  15      


Leu Trp Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala 
            20                  25                  30          


Val Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met 
        35                  40                  45              


Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn 
    50                  55                  60                  


Ala Gln Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr 
65                  70                  75                  80  


Ile Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala Leu 
                85                  90                  95      


Glu Lys Leu Phe Leu Gln Lys Ile Asn Glu Leu 
            100                 105         


<210>  5
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  5

Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys His 
1               5                   10                  15      


Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala Leu 
            20                  25                  30          


Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met Ser 
        35                  40                  45              


Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln Glu 
    50                  55                  60                  


Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn 
65                  70                  75                  80  


Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp Val 
                85                  90                  95      


Phe Glu Met Arg Phe 
            100     


<210>  6
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  6

Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr 
1               5                   10                  15      


Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln 
            20                  25                  30          


Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Asn Pro Met Asp 
        35                  40                  45              


Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro 
    50                  55                  60                  


Trp Gln Tyr Val Asp Asp Val Trp Leu Met Phe Asn Asn Ala Trp Leu 
65                  70                  75                  80  


Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Phe Cys Ser Lys Leu Ala 
                85                  90                  95      


Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln 
            100                 105             


<210>  7
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  7

Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu Gln Gln Val Lys Ser His 
1               5                   10                  15      


Gln Ser Ala Trp Pro Phe Met Glu Pro Val Lys Arg Thr Glu Ala Pro 
            20                  25                  30          


Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met Asp Leu Lys Thr Met Ser 
        35                  40                  45              


Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser Lys Lys Leu Phe Met Ala 
    50                  55                  60                  


Asp Leu Gln Arg Val Phe Thr Asn Cys Lys Glu Tyr Asn Ala Ala Glu 
65                  70                  75                  80  


Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu Glu Lys Phe Phe Phe Ser 
                85                  90                  95      


Lys Ile Lys Glu 
            100 


<210>  8
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  8

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
            20                  25                  30          


Trp Asn Trp Phe 
        35      


<210>  9
<211>  801
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro 
    610                 615                 620                 


Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg 
625                 630                 635                 640 


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
                645                 650                 655     


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg 
            660                 665                 670         


Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe 
        675                 680                 685             


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu 
    690                 695                 700                 


Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro 
705                 710                 715                 720 


Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu 
                725                 730                 735     


Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys 
            740                 745                 750         


Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln 
        755                 760                 765             


Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Gly 
    


<210>  10
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  10

Arg Val Thr Asn Gln Leu Gln Tyr Leu His Lys Val Val Met Lys Ala 
1               5                   10                  15      


Leu Trp Lys His Gln Phe Ala Trp Pro Phe Arg Gln Pro Val Asp Ala 
            20                  25                  30          


Val Lys Leu Gly Leu Pro Asp Tyr His Lys Ile Ile Lys Gln Pro Met 
        35                  40                  45              


Asp Met Gly Thr Ile Lys Arg Arg Leu Glu Asn Asn Tyr Tyr Trp Ala 
    50                  55                  60                  


Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr 
65                  70                  75                  80  


Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Thr Leu 
                85                  90                  95      


Glu Lys Ile Phe Leu Gln Lys Val Ala Ser Met 
            100                 105         


<210>  11
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  11

Gln Leu Lys His Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys 
1               5                   10                  15      


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala 
            20                  25                  30          


Leu Gly Leu His Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu 
        35                  40                  45              


Ser Thr Val Lys Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln 
    50                  55                  60                  


Glu Phe Ala Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
65                  70                  75                  80  


Asn Pro Pro Asp His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp 
                85                  90                  95      


Val Phe Glu Phe Arg Tyr 
            100         


<210>  12
<211>  732
<212>  PRT
<213>  Homo Sapiens

<400>  12

Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln 
            180                 185                 190         


Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val 
        195                 200                 205             


Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile 
                245                 250                 255     


Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Phe Ile Gly Arg Glu Gly Glu Ala Pro Ala Leu Pro 
            420                 425                 430         


Ala Pro Ala Ala Pro Met Val Ser Lys Gly Ala Glu Ser Ser Arg Ser 
        435                 440                 445             


Ser Glu Glu Ser Ser Ser Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu 
    450                 455                 460                 


Arg Ala Thr Arg Leu Ala Glu Leu Gln Glu Gln Leu Lys Ala Val His 
465                 470                 475                 480 


Glu Gln Leu Ala Ala Leu Ser Gln Ala Pro Val Asn Lys Pro Lys Lys 
                485                 490                 495     


Lys Lys Glu Lys Lys Glu Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys 
            500                 505                 510         


Glu Lys Glu Lys His Lys Val Lys Ala Glu Glu Glu Lys Lys Ala Lys 
        515                 520                 525             


Val Ala Pro Pro Ala Lys Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys 
    530                 535                 540                 


Lys Ala Asn Ser Thr Thr Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly 
545                 550                 555                 560 


Lys Gln Ala Ser Ala Ser Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu 
                565                 570                 575     


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg 
            580                 585                 590         


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
        595                 600                 605             


Glu Pro Ser Leu Arg Asp Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
    610                 615                 620                 


Glu Thr Leu Lys Pro Thr Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys 
625                 630                 635                 640 


Ser Cys Leu Gln Lys Lys Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys 
                645                 650                 655     


Lys Gln Ala Ala Lys Ser Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys 
            660                 665                 670         


Glu Leu Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Ser Ser Ser 
        675                 680                 685             


Lys Lys Pro Ala Arg Lys Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly 
    690                 695                 700                 


Pro Ser Arg Leu Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Gly Ser Ser Ser Asp Ser Ser Asp Ser Glu 
                725                 730         


<210>  13
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  13

Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys Thr 
1               5                   10                  15      


Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp Ala 
            20                  25                  30          


Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro Met 
        35                  40                  45              


Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Ser 
    50                  55                  60                  


Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr 
65                  70                  75                  80  


Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala Leu 
                85                  90                  95      


Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met 
            100                 105         


<210>  14
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  14

His Leu Arg Tyr Cys Asp Ser Ile Leu Arg Glu Met Leu Ser Lys Lys 
1               5                   10                  15      


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Glu Ala 
            20                  25                  30          


Leu Glu Leu His Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu 
        35                  40                  45              


Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu Tyr Pro Asp Ala Gln 
    50                  55                  60                  


Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
65                  70                  75                  80  


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
                85                  90                  95      


Val Phe Glu Met Arg Phe 
            100         


<210>  15
<211>  1058
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Arg Arg Lys Gly Arg Cys His Arg Gly Ser Ala Ala Arg His Pro 
1               5                   10                  15      


Ser Ser Pro Cys Ser Val Lys His Ser Pro Thr Arg Glu Thr Leu Thr 
            20                  25                  30          


Tyr Ala Gln Ala Gln Arg Met Val Glu Ile Glu Ile Glu Gly Arg Leu 
        35                  40                  45              


His Arg Ile Ser Ile Phe Asp Pro Leu Glu Ile Ile Leu Glu Asp Asp 
    50                  55                  60                  


Leu Thr Ala Gln Glu Met Ser Glu Cys Asn Ser Asn Lys Glu Asn Ser 
65                  70                  75                  80  


Glu Arg Pro Pro Val Cys Leu Arg Thr Lys Arg His Lys Asn Asn Arg 
                85                  90                  95      


Val Lys Lys Lys Asn Glu Ala Leu Pro Ser Ala His Gly Thr Pro Ala 
            100                 105                 110         


Ser Ala Ser Ala Leu Pro Glu Pro Lys Val Arg Ile Val Glu Tyr Ser 
        115                 120                 125             


Pro Pro Ser Ala Pro Arg Arg Pro Pro Val Tyr Tyr Lys Phe Ile Glu 
    130                 135                 140                 


Lys Ser Ala Glu Glu Leu Asp Asn Glu Val Glu Tyr Asp Met Asp Glu 
145                 150                 155                 160 


Glu Asp Tyr Ala Trp Leu Glu Ile Val Asn Glu Lys Arg Lys Gly Asp 
                165                 170                 175     


Cys Val Pro Ala Val Ser Gln Ser Met Phe Glu Phe Leu Met Asp Arg 
            180                 185                 190         


Phe Glu Lys Glu Ser His Cys Glu Asn Gln Lys Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Leu Ile Asp Glu Asp Ala Val Cys Cys Ile Cys Met Asp Gly Glu 
    210                 215                 220                 


Cys Gln Asn Ser Asn Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala 
225                 230                 235                 240 


Val His Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp 
                245                 250                 255     


Leu Cys Arg His Cys Leu Gln Ser Arg Ala Arg Pro Ala Asp Cys Val 
            260                 265                 270         


Leu Cys Pro Asn Lys Gly Gly Ala Phe Lys Lys Thr Asp Asp Asp Arg 
        275                 280                 285             


Trp Gly His Val Val Cys Ala Leu Trp Ile Pro Glu Val Gly Phe Ala 
    290                 295                 300                 


Asn Thr Val Phe Ile Glu Pro Ile Asp Gly Val Arg Asn Ile Pro Pro 
305                 310                 315                 320 


Ala Arg Trp Lys Leu Thr Cys Tyr Leu Cys Lys Gln Lys Gly Val Gly 
                325                 330                 335     


Ala Cys Ile Gln Cys His Lys Ala Asn Cys Tyr Thr Ala Phe His Val 
            340                 345                 350         


Thr Cys Ala Gln Lys Ala Gly Leu Tyr Met Lys Met Glu Pro Val Lys 
        355                 360                 365             


Glu Leu Thr Gly Gly Gly Thr Thr Phe Ser Val Arg Lys Thr Ala Tyr 
    370                 375                 380                 


Cys Asp Val His Thr Pro Pro Gly Cys Thr Arg Arg Pro Leu Asn Ile 
385                 390                 395                 400 


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
                405                 410                 415     


Val Lys Thr Val Arg Ser Thr Ser Lys Val Arg Lys Lys Ala Lys Lys 
            420                 425                 430         


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Thr Val Cys 
        435                 440                 445             


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
    450                 455                 460                 


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
465                 470                 475                 480 


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
                485                 490                 495     


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
            500                 505                 510         


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
        515                 520                 525             


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
    530                 535                 540                 


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
545                 550                 555                 560 


Glu Leu Arg Leu Thr Pro Leu Thr Val Leu Leu Arg Ser Val Leu Asp 
                565                 570                 575     


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
            580                 585                 590         


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
        595                 600                 605             


Phe Ala Thr Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
    610                 615                 620                 


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
625                 630                 635                 640 


Tyr Asn Ala Arg Asp Thr Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
                645                 650                 655     


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
            660                 665                 670         


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
        675                 680                 685             


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
    690                 695                 700                 


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
705                 710                 715                 720 


Leu Leu Asp Met Leu Asp Leu Thr Cys Ala Met Lys Ser Ser Gly Ser 
                725                 730                 735     


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
            740                 745                 750         


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Thr Gly Pro Gly 
        755                 760                 765             


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
    770                 775                 780                 


Glu Glu Val Leu Pro Arg Leu Glu Thr Leu Leu Gln Pro Arg Lys Arg 
785                 790                 795                 800 


Ser Arg Ser Thr Cys Gly Asp Ser Glu Val Glu Glu Glu Ser Pro Gly 
                805                 810                 815     


Lys Arg Leu Asp Ala Gly Leu Thr Asn Gly Phe Gly Gly Ala Arg Ser 
            820                 825                 830         


Glu Gln Glu Pro Gly Gly Gly Leu Gly Arg Lys Ala Thr Pro Arg Arg 
        835                 840                 845             


Arg Cys Ala Ser Glu Ser Ser Ile Ser Ser Ser Asn Ser Pro Leu Cys 
    850                 855                 860                 


Asp Ser Ser Phe Asn Ala Pro Lys Cys Gly Arg Gly Lys Pro Ala Leu 
865                 870                 875                 880 


Val Arg Arg His Thr Leu Glu Asp Arg Ser Glu Leu Ile Ser Cys Ile 
                885                 890                 895     


Glu Asn Gly Asn Tyr Ala Lys Ala Ala Arg Ile Ala Ala Glu Val Gly 
            900                 905                 910         


Gln Ser Ser Met Trp Ile Ser Thr Asp Ala Ala Ala Ser Val Leu Glu 
        915                 920                 925             


Pro Leu Lys Val Val Trp Ala Lys Cys Ser Gly Tyr Pro Ser Tyr Pro 
    930                 935                 940                 


Ala Leu Ile Ile Asp Pro Lys Met Pro Arg Val Pro Gly His His Asn 
945                 950                 955                 960 


Gly Val Thr Ile Pro Ala Pro Pro Leu Asp Val Leu Lys Ile Gly Glu 
                965                 970                 975     


His Met Gln Thr Lys Ser Asp Glu Lys Leu Phe Leu Val Leu Phe Phe 
            980                 985                 990         


Asp Asn Lys Arg Ser Trp Gln Trp  Leu Pro Lys Ser Lys  Met Val Pro 
        995                 1000                 1005             


Leu Gly  Ile Asp Glu Thr Ile  Asp Lys Leu Lys Met  Met Glu Gly 
    1010                 1015                 1020             


Arg Asn  Ser Ser Ile Arg Lys  Ala Val Arg Ile Ala  Phe Asp Arg 
    1025                 1030                 1035             


Ala Met  Asn His Leu Ser Arg  Val His Gly Glu Pro  Thr Ser Asp 
    1040                 1045                 1050             


Leu Ser  Asp Ile Asp 
    1055             


<210>  16
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  16

Pro Leu Thr Val Leu Leu Arg Ser Val Leu Asp Gln Leu Gln Asp Lys 
1               5                   10                  15      


Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser Leu Lys Glu Val Pro 
            20                  25                  30          


Asp Tyr Leu Asp His Ile Lys His Pro Met Asp Phe Ala Thr Met Arg 
        35                  40                  45              


Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu His Glu Phe Glu Glu 
    50                  55                  60                  


Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys Tyr Asn Ala Arg Asp 
65                  70                  75                  80  


Thr Val Phe Tyr Arg Ala Ala Val Arg Leu Arg Asp Gln Gly Gly Val 
                85                  90                  95      


Val Leu 
        


<210>  17
<211>  947
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Ser Leu Pro Ser Arg Gln Thr Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Thr Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Thr Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Thr Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Thr Ala Ala Gln Val Thr 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Ala Thr Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Thr Phe Thr Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Thr Val Lys Val Thr Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Thr His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Thr Asp Ile Thr Glu Thr Thr Gly Arg Glu 
385                 390                 395                 400 


Asn Thr Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu Lys Val 
    450                 455                 460                 


Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln Gln Phe 
                485                 490                 495     


Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met Asn Tyr 
            500                 505                 510         


Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro Gly Asp 
        515                 520                 525             


Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu 
    530                 535                 540                 


Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys 
545                 550                 555                 560 


Ala Ser Thr Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys Leu Arg 
                565                 570                 575     


Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser Lys Glu 
            580                 585                 590         


Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu Leu Asp 
        595                 600                 605             


Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Thr Lys Ser Asp Lys 
    610                 615                 620                 


Thr Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser Glu Ser 
625                 630                 635                 640 


Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser Ser Asp 
                645                 650                 655     


Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe Pro Lys 
            660                 665                 670         


Phe Thr Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn Val Lys 
        675                 680                 685             


Lys Met Lys Asn Glu Cys Ile Leu Pro Glu Gly Arg Thr Gly Val Thr 
    690                 695                 700                 


Gln Ile Gly Tyr Cys Val Gln Asp Thr Thr Ser Ala Asn Thr Thr Leu 
705                 710                 715                 720 


Val His Gln Thr Thr Pro Ser His Val Met Pro Pro Asn His His Gln 
                725                 730                 735     


Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Thr Val Lys Asn 
            740                 745                 750         


Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu Gln Leu 
        755                 760                 765             


Ser Asn Gly Ile Thr Val Met His Pro Ser Gly Asp Ser Asp Thr Thr 
    770                 775                 780                 


Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile Lys Ile 
785                 790                 795                 800 


Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys Pro Ser 
                805                 810                 815     


Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg Lys Ala 
            820                 825                 830         


Ala Ile Glu Lys Glu Val Lys Ala Arg Thr Gln Glu Leu Ile Arg Lys 
        835                 840                 845             


His Leu Glu Gln Asn Thr Lys Glu Leu Lys Ala Ser Gln Glu Asn Gln 
    850                 855                 860                 


Arg Asp Leu Gly Asn Gly Leu Thr Val Glu Ser Phe Ser Asn Lys Ile 
865                 870                 875                 880 


Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln Ser Ser 
                885                 890                 895     


Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg Asp Leu 
            900                 905                 910         


Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Val Gly 
        915                 920                 925             


Thr Ile Asp Met Thr Leu Gln Ser Asp Ile Met Thr Met Phe Glu Asn 
    930                 935                 940                 


Asn Phe Asp 
945         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  18

Arg Leu Thr Asn Gln Leu Gln Tyr Leu Gln Lys Val Val Leu Lys Asp 
1               5                   10                  15      


Leu Trp Lys His Ser Phe Ser Trp Pro Phe Gln Arg Pro Val Asp Ala 
            20                  25                  30          


Val Lys Leu Gln Leu Pro Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met 
        35                  40                  45              


Asp Leu Asn Thr Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys 
    50                  55                  60                  


Ala Ser Glu Cys Ile Glu Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr 
65                  70                  75                  80  


Leu Tyr Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Gln Ala Leu 
                85                  90                  95      


Glu Lys Leu Phe Met Gln Lys Leu Ser Gln Met 
            100                 105         


<210>  19
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  19

Gln Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys 
1               5                   10                  15      


His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala 
            20                  25                  30          


Leu Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu 
        35                  40                  45              


Gly Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr 
    50                  55                  60                  


Lys Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr 
65                  70                  75                  80  


Asn Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp 
                85                  90                  95      


Val Phe Glu Thr His Phe 
            100         


<210>  20
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Thr Glu Leu Ser Thr Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Thr Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Thr Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Thr Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Thr Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Thr Asp Thr Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Thr Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Thr Thr Thr Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Thr Thr Gly Arg Leu Gln Ser Gly Val Asn Thr 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Thr Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Thr Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Thr 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Thr Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Thr Lys Gly Gly His Ser Arg Thr Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Thr Arg Thr Leu Asp Thr Ala 
                485                 490                 495     


Lys Glu Met Glu Gln Ile Thr Glu Val Glu Pro Pro Gly Arg Leu Asp 
            500                 505                 510         


Ser Ser Thr Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Thr Asn Phe 
        515                 520                 525             


Gly Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln 
    530                 535                 540                 


Lys Lys Leu Asp Glu Thr Thr Arg Leu Leu Arg Glu Leu Gln Glu Ala 
545                 550                 555                 560 


Gln Asn Glu Arg Leu Ser Thr Arg Pro Pro Pro Asn Met Ile Cys Leu 
                565                 570                 575     


Leu Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Thr Asn 
            580                 585                 590         


Asn Leu Lys Glu Leu Ala Gln Gln Val Thr Pro Gly Asp Ile Val Ser 
        595                 600                 605             


Thr Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val 
    610                 615                 620                 


Met Glu Asn Asn Phe Val Asp Leu Thr Glu Asp Thr Glu Glu Pro Lys 
625                 630                 635                 640 


Lys Thr Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650         


<210>  21
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  21

Pro Leu Gln Glu Ala Leu Asn Gln Leu Met Arg Gln Leu Gln Arg Lys 
1               5                   10                  15      


Asp Pro Ser Ala Phe Phe Ser Phe Pro Val Thr Asp Phe Ile Ala Pro 
            20                  25                  30          


Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe Ser Thr Met Lys 
        35                  40                  45              


Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser Ile Glu Glu Leu Lys Asp 
    50                  55                  60                  


Asn Phe Lys Leu Met Cys Thr Asn Ala Met Ile Tyr Asn Lys Pro Glu 
65                  70                  75                  80  


Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu Leu His Ser Gly Met Lys 
                85                  90                  95      


Ile Leu 
        


<210>  22
<211>  651
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Thr Glu Leu Ser Thr Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Thr Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Thr Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Thr Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Thr Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Thr Asp Thr Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Thr Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Thr Thr Thr Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Thr Thr Gly Arg Leu Gln Ser Gly Val Asn Thr 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Thr Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Thr Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Thr 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Thr Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Thr Lys Gly Gly His Ser Arg Thr Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Thr Arg Thr Leu Asp Thr Ala 
                485                 490                 495     


Lys Glu Met Glu Ile Thr Glu Val Glu Pro Pro Gly Arg Leu Asp Ser 
            500                 505                 510         


Ser Thr Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Thr Asn Phe Gly 
        515                 520                 525             


Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln Lys 
    530                 535                 540                 


Lys Leu Asp Glu Thr Thr Arg Leu Leu Arg Glu Leu Gln Glu Ala Gln 
545                 550                 555                 560 


Asn Glu Arg Leu Ser Thr Arg Pro Pro Pro Asn Met Ile Cys Leu Leu 
                565                 570                 575     


Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Thr Asn Asn 
            580                 585                 590         


Leu Lys Glu Leu Ala Gln Gln Val Thr Pro Gly Asp Ile Val Ser Thr 
        595                 600                 605             


Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val Met 
    610                 615                 620                 


Glu Asn Asn Phe Val Asp Leu Thr Glu Asp Thr Glu Glu Pro Lys Lys 
625                 630                 635                 640 


Thr Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650     


<210>  23
<211>  957
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro 
    210                 215                 220                 


Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Gly 
                325                 330                 335     


Ala Pro Thr Leu Ser Arg Leu Leu Glu Ala Gly Pro Thr Gln Phe Thr 
            340                 345                 350         


Thr Pro Leu Ala Ser Phe Thr Thr Val Ala Ser Glu Pro Pro Val Lys 
        355                 360                 365             


Leu Val Pro Pro Pro Val Glu Ser Val Ser Gln Ala Thr Ile Val Met 
    370                 375                 380                 


Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr 
385                 390                 395                 400 


Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu 
                405                 410                 415     


Ala Val Gly Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu 
            420                 425                 430         


Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly 
        435                 440                 445             


Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys 
    450                 455                 460                 


Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr 
465                 470                 475                 480 


Gly Glu Glu Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile 
                485                 490                 495     


Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val 
            500                 505                 510         


Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu 
        515                 520                 525             


Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val 
    530                 535                 540                 


Pro Leu Pro Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe 
545                 550                 555                 560 


Glu Glu Thr Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu 
                565                 570                 575     


Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile 
            580                 585                 590         


Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu 
        595                 600                 605             


Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr 
    610                 615                 620                 


Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp 
625                 630                 635                 640 


Glu Thr Pro Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met 
                645                 650                 655     


Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala 
            660                 665                 670         


Glu Thr Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser 
        675                 680                 685             


Gly Thr Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu 
    690                 695                 700                 


Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu 
705                 710                 715                 720 


Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro 
                725                 730                 735     


Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln 
            740                 745                 750         


Ser His Thr Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln 
        755                 760                 765             


Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile 
    770                 775                 780                 


Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg 
785                 790                 795                 800 


Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly 
                805                 810                 815     


Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys 
            820                 825                 830         


Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp 
        835                 840                 845             


Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His 
    850                 855                 860                 


Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln 
865                 870                 875                 880 


Ile Gln Gln Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser 
                885                 890                 895     


Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln 
            900                 905                 910         


Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu 
        915                 920                 925             


Leu Ser Leu Phe Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu 
    930                 935                 940                 


Ala Asp Met Lys Met Lys Lys Ser Glu Gln Ile Asp Asn 
945                 950                 955         


<210>  24
<211>  104
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  24

Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala 
1               5                   10                  15      


Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp Ile 
            20                  25                  30          


Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Thr 
        35                  40                  45              


Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe 
    50                  55                  60                  


Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser 
65                  70                  75                  80  


Ser Asp His Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val 
                85                  90                  95      


Leu Glu Gln Ile Gln Gln Phe Leu 
            100                 


<210>  25
<211>  1241
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Asn Glu Ser Glu Met Ala Val Ala Ser 
    210                 215                 220                 


Gly His Leu Asn Ser Thr Gly Val Leu Leu Glu Val Gly Gly Val Leu 
225                 230                 235                 240 


Pro Met Ile His Gly Gly Glu Ile Gln Gln Thr Pro Asn Thr Val Ala 
                245                 250                 255     


Ala Ser Pro Ala Ala Ser Gly Ala Pro Thr Leu Ser Arg Leu Leu Glu 
            260                 265                 270         


Ala Gly Pro Thr Gln Phe Thr Thr Pro Leu Ala Ser Phe Thr Thr Val 
        275                 280                 285             


Ala Ser Glu Pro Pro Val Lys Leu Val Pro Pro Pro Val Glu Ser Val 
    290                 295                 300                 


Ser Gln Ala Thr Ile Val Met Met Pro Ala Leu Pro Ala Pro Ser Ser 
305                 310                 315                 320 


Ala Pro Ala Val Ser Thr Thr Glu Ser Val Ala Pro Val Ser Gln Pro 
                325                 330                 335     


Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His Thr Val Thr 
            340                 345                 350         


Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn Ser Ile Lys 
        355                 360                 365             


Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val Gly Ser Lys 
    370                 375                 380                 


Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala Glu Lys Met 
385                 390                 395                 400 


Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu Leu Asp Phe Glu Thr Val 
                405                 410                 415     


Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp His Pro Glu 
            420                 425                 430         


Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe Cys Glu Glu 
        435                 440                 445             


Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His Pro Ile Gln 
    450                 455                 460                 


Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu Met Thr Val 
465                 470                 475                 480 


Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr Glu Asn Lys Gly Ile His 
                485                 490                 495     


Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys Val Glu Pro 
            500                 505                 510         


Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val Ala Gly Val 
        515                 520                 525             


Val Pro Ala Thr Ser Met Glu Pro Pro Glu Leu Arg Ser Gln Asp Leu 
    530                 535                 540                 


Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly Glu Ile Val Glu Ala Asp 
545                 550                 555                 560 


Val Ala Ile Gly Lys Gly Asp Glu Thr Pro Leu Thr Asn Val Lys Thr 
                565                 570                 575     


Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly Ser Asn Pro 
            580                 585                 590         


Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln His Lys Phe Glu Met Ser 
        595                 600                 605             


Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile Phe Gly Ser Gln Ile Lys 
    610                 615                 620                 


Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser Glu Ala Ala 
625                 630                 635                 640 


Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly Tyr Leu Ser 
                645                 650                 655     


Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp Gly Phe Ser 
            660                 665                 670         


Ile His Asn Ala Thr Leu Gln Ser His Thr Leu Ala Asp Ser Ile Pro 
        675                 680                 685             


Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu Asp Gln Glu 
    690                 695                 700                 


Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met Leu Val Trp 
705                 710                 715                 720 


Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val 
                725                 730                 735     


Thr Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met 
            740                 745                 750         


Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser 
        755                 760                 765             


Thr Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val 
    770                 775                 780                 


Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala Val Glu Met 
785                 790                 795                 800 


Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala Thr Gln Leu 
                805                 810                 815     


Ile Met Gln Thr Ser Glu Ser Gly Ile Ser Ala Lys Ser Leu Arg Gly 
            820                 825                 830         


Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser Glu Lys Asp Ser Val Pro 
        835                 840                 845             


Met Gly Ser Pro Ala Phe Leu Leu Ser Leu Phe Met Gly His Glu Trp 
    850                 855                 860                 


Val Trp Leu Asp Ser Glu Gln Asp His Pro Asn Asp Ser Glu Leu Ser 
865                 870                 875                 880 


Asn Asp Cys Arg Ser Leu Phe Ser Ser Trp Asp Ser Ser Leu Asp Leu 
                885                 890                 895     


Asp Val Gly Asn Trp Arg Glu Thr Glu Asp Pro Glu Ala Glu Glu Leu 
            900                 905                 910         


Glu Glu Ser Ser Pro Glu Arg Glu Pro Ser Glu Leu Leu Val Gly Asp 
        915                 920                 925             


Gly Gly Ser Glu Glu Ser Gln Glu Ala Ala Arg Lys Ala Ser His Gln 
    930                 935                 940                 


Asn Leu Leu His Phe Leu Ser Glu Val Ala Tyr Leu Met Glu Pro Leu 
945                 950                 955                 960 


Cys Ile Ser Ser Asn Glu Ser Ser Glu Gly Cys Cys Pro Pro Ser Gly 
                965                 970                 975     


Thr Arg Gln Glu Gly Arg Glu Ile Lys Ala Ser Glu Gly Glu Arg Glu 
            980                 985                 990         


Leu Cys Arg Glu Thr Glu Glu Leu  Ser Ala Lys Gly Asp  Pro Leu Val 
        995                 1000                 1005             


Ala Glu  Lys Pro Leu Gly Glu  Asn Gly Lys Pro Glu  Val Ala Ser 
    1010                 1015                 1020             


Ala Pro  Ser Val Ile Cys Thr  Val Gln Gly Leu Leu  Thr Glu Ser 
    1025                 1030                 1035             


Glu Glu  Gly Glu Ala Gln Gln  Glu Ser Lys Gly Glu  Asp Gln Gly 
    1040                 1045                 1050             


Glu Val  Tyr Val Ser Glu Met  Glu Asp Gln Pro Pro  Ser Gly Glu 
    1055                 1060                 1065             


Cys Asp  Asp Ala Phe Asn Ile  Lys Glu Thr Pro Leu  Val Asp Thr 
    1070                 1075                 1080             


Leu Phe  Ser His Ala Thr Ser  Ser Lys Leu Thr Asp  Leu Ser Gln 
    1085                 1090                 1095             


Asp Asp  Pro Val Gln Asp His  Leu Leu Phe Lys Lys  Thr Leu Leu 
    1100                 1105                 1110             


Pro Val  Trp Lys Met Ile Ala  Ser His Arg Phe Ser  Ser Pro Phe 
    1115                 1120                 1125             


Leu Lys  Pro Val Ser Glu Arg  Gln Ala Pro Gly Tyr  Lys Asp Val 
    1130                 1135                 1140             


Val Lys  Arg Pro Met Asp Leu  Thr Ser Leu Lys Arg  Asn Leu Ser 
    1145                 1150                 1155             


Lys Gly  Arg Ile Arg Thr Met  Ala Gln Phe Leu Arg  Asp Leu Met 
    1160                 1165                 1170             


Leu Met  Phe Gln Asn Ala Val  Met Tyr Asn Asp Ser  Asp His His 
    1175                 1180                 1185             


Val Tyr  His Met Ala Val Glu  Met Arg Arg Glu Val  Leu Glu Gln 
    1190                 1195                 1200             


Ile Gln  Val Leu Asn Ile Trp  Leu Asp Lys Arg Lys  Gly Ser Ser 
    1205                 1210                 1215             


Ser Leu  Glu Gly Glu Pro Ala  Asn Pro Val Asp Asp  Gly Lys Pro 
    1220                 1225                 1230             


Val Phe  Ser Glu Gln Ile Asp  Asn 
    1235                 1240     


<210>  26
<211>  866
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro 
    210                 215                 220                 


Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Val 
                325                 330                 335     


Ser Gln Pro Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His 
            340                 345                 350         


Thr Val Thr Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn 
        355                 360                 365             


Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val 
    370                 375                 380                 


Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Glu Lys Met Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu Leu Asp Phe 
                405                 410                 415     


Glu Thr Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp 
            420                 425                 430         


His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe 
        435                 440                 445             


Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His 
    450                 455                 460                 


Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu 
465                 470                 475                 480 


Met Thr Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr Glu Asn Lys 
                485                 490                 495     


Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys 
            500                 505                 510         


Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val 
        515                 520                 525             


Ala Gly Val Val Pro Ala Thr Ser Met Glu Pro Pro Glu Leu Arg Ser 
    530                 535                 540                 


Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly Glu Ile Val 
545                 550                 555                 560 


Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Thr Pro Leu Thr Asn 
                565                 570                 575     


Val Lys Thr Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly 
            580                 585                 590         


Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln His Lys Phe 
        595                 600                 605             


Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile Phe Gly Ser 
    610                 615                 620                 


Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser 
625                 630                 635                 640 


Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly 
                645                 650                 655     


Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp 
            660                 665                 670         


Gly Phe Ser Ile His Asn Ala Thr Leu Gln Ser His Thr Leu Ala Asp 
        675                 680                 685             


Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu 
    690                 695                 700                 


Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met 
705                 710                 715                 720 


Leu Val Trp Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu 
                725                 730                 735     


Gln Pro Val Thr Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln 
            740                 745                 750         


Arg Pro Met Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu 
        755                 760                 765             


Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln 
    770                 775                 780                 


Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala 
785                 790                 795                 800 


Val Glu Met Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala 
                805                 810                 815     


Thr Gln Leu Ile Met Gln Thr Ser Glu Ser Gly Ile Ser Ala Lys Ser 
            820                 825                 830         


Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser Glu Lys Asp 
        835                 840                 845             


Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu Ala Asp Met Lys Met 
    850                 855                 860                 


Lys Lys 
865     


<210>  27
<211>  597
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Gly Lys Lys His Lys Lys His Lys Ala Glu Trp Arg Ser Ser Tyr 
1               5                   10                  15      


Glu Asp Tyr Ala Asp Lys Pro Leu Glu Lys Pro Leu Lys Leu Val Leu 
            20                  25                  30          


Lys Val Gly Gly Ser Glu Val Thr Glu Leu Ser Gly Ser Gly His Asp 
        35                  40                  45              


Ser Ser Tyr Tyr Asp Asp Arg Ser Asp His Glu Arg Glu Arg His Lys 
    50                  55                  60                  


Glu Lys Lys Lys Lys Lys Lys Lys Lys Ser Glu Lys Glu Lys His Leu 
65                  70                  75                  80  


Asp Asp Glu Glu Arg Arg Lys Arg Lys Glu Glu Lys Lys Arg Lys Arg 
                85                  90                  95      


Glu Arg Glu His Cys Asp Thr Glu Gly Glu Ala Asp Asp Phe Asp Pro 
            100                 105                 110         


Gly Lys Lys Val Glu Val Glu Pro Pro Pro Asp Arg Pro Val Arg Ala 
        115                 120                 125             


Cys Arg Thr Gln Pro Ala Glu Asn Glu Ser Thr Pro Ile Gln Gln Leu 
    130                 135                 140                 


Leu Glu His Phe Leu Arg Gln Leu Gln Arg Lys Asp Pro His Gly Phe 
145                 150                 155                 160 


Phe Ala Phe Pro Val Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile 
                165                 170                 175     


Ile Lys His Pro Met Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala 
            180                 185                 190         


Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met 
        195                 200                 205             


Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys 
    210                 215                 220                 


Leu Ala Lys Lys Ile Leu His Ala Gly Phe Lys Met Met Ser Lys Gln 
225                 230                 235                 240 


Ala Ala Leu Leu Gly Asn Glu Asp Thr Ala Val Glu Glu Pro Val Pro 
                245                 250                 255     


Glu Val Val Pro Val Gln Val Glu Thr Ala Lys Lys Ser Lys Lys Pro 
            260                 265                 270         


Ser Arg Glu Val Ile Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys 
        275                 280                 285             


Ser Leu Thr Asp Ser Thr Ala Glu Glu His Val Leu Ala Leu Val Glu 
    290                 295                 300                 


His Ala Ala Asp Glu Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly 
305                 310                 315                 320 


Gly Lys Met Gly Tyr Leu Lys Arg Asn Gly Asp Gly Ser Leu Leu Tyr 
                325                 330                 335     


Ser Val Val Asn Thr Ala Glu Pro Asp Ala Asp Glu Glu Glu Thr His 
            340                 345                 350         


Pro Val Asp Leu Ser Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr 
        355                 360                 365             


Thr Leu Gly Phe Lys Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser 
    370                 375                 380                 


Ser Ala Thr Thr Ala Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp 
385                 390                 395                 400 


Leu Lys Ser Asp Glu Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu 
                405                 410                 415     


Thr Gly Val Gln Cys Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala 
            420                 425                 430         


Gly Ser Tyr Ser Lys Lys Val Val Asp Asp Leu Leu Asp Gln Ile Thr 
        435                 440                 445             


Gly Gly Asp His Ser Arg Thr Leu Phe Gln Leu Lys Gln Arg Arg Asn 
    450                 455                 460                 


Val Pro Met Lys Pro Pro Asp Glu Ala Lys Val Gly Asp Thr Leu Gly 
465                 470                 475                 480 


Asp Ser Ser Ser Ser Val Leu Glu Phe Met Ser Met Lys Ser Tyr Pro 
                485                 490                 495     


Asp Val Ser Val Asp Ile Ser Met Leu Ser Ser Leu Gly Lys Val Lys 
            500                 505                 510         


Lys Glu Leu Asp Pro Asp Asp Ser His Leu Asn Leu Asp Glu Thr Thr 
        515                 520                 525             


Lys Leu Leu Gln Asp Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser 
    530                 535                 540                 


Arg Pro Ser Ser Asn Leu Ser Ser Leu Ser Asn Ala Ser Glu Arg Asp 
545                 550                 555                 560 


Gln His His Leu Gly Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro 
                565                 570                 575     


Asp Val Thr His Asp Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala 
            580                 585                 590         


Ala Ser Ala Lys Thr 
        595         


<210>  28
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  28

Pro Ile Gln Gln Leu Leu Glu His Phe Leu Arg Gln Leu Gln Arg Lys 
1               5                   10                  15      


Asp Pro His Gly Phe Phe Ala Phe Pro Val Thr Asp Ala Ile Ala Pro 
            20                  25                  30          


Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe Gly Thr Met Lys 
        35                  40                  45              


Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys Ala 
    50                  55                  60                  


Asp Phe Lys Leu Met Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro Asp 
65                  70                  75                  80  


Thr Val Tyr Tyr Lys Leu Ala Lys Lys Ile Leu His Ala Gly Phe Lys 
                85                  90                  95      


Met Met 
        


<210>  29
<211>  550
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Met Thr Gly Gln Thr Met Ser Glu Arg Gly Thr Lys Lys Arg Lys 
1               5                   10                  15      


Arg Arg Arg Arg Arg Ser Pro Arg Arg Arg Ser Ile Trp Thr Met Arg 
            20                  25                  30          


Lys Glu Gly Ser Glu Arg Lys Arg Arg Ser Gly Ser Glu Arg Gly Ser 
        35                  40                  45              


Thr Val Thr Arg Arg Glu Arg Leu Thr Thr Leu Ile Leu Gly Arg Arg 
    50                  55                  60                  


Trp Arg Trp Ser Arg Pro Gln Ile Gly Gln Ser Glu Arg Ala Gly His 
65                  70                  75                  80  


Ser Gln Pro Lys Met Arg Ala His Leu Phe Ser Asn Ser Trp Asn Thr 
                85                  90                  95      


Ser Ser Ala Ser Phe Arg Asp Pro His Gly Phe Phe Ala Phe Pro Val 
            100                 105                 110         


Thr Asp Ala Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
        115                 120                 125             


Asp Phe Gly Thr Met Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser 
    130                 135                 140                 


Val Thr Glu Phe Lys Ala Asp Phe Lys Leu Met Cys Asp Asn Ala Met 
145                 150                 155                 160 


Thr Tyr Asn Arg Pro Asp Thr Val Tyr Tyr Lys Leu Ala Lys Lys Ile 
                165                 170                 175     


Leu His Ala Gly Phe Lys Met Met Ser Lys Gln Ala Ala Leu Leu Gly 
            180                 185                 190         


Asn Glu Asp Thr Ala Val Glu Glu Pro Val Pro Glu Val Val Pro Val 
        195                 200                 205             


Gln Val Glu Thr Ala Lys Lys Ser Lys Lys Pro Ser Arg Glu Val Ile 
    210                 215                 220                 


Ser Cys Met Phe Glu Pro Glu Gly Asn Ala Cys Ser Leu Thr Asp Ser 
225                 230                 235                 240 


Thr Ala Glu Glu His Val Leu Ala Leu Val Glu His Ala Ala Asp Glu 
                245                 250                 255     


Ala Arg Asp Arg Ile Asn Arg Phe Leu Pro Gly Gly Lys Met Gly Tyr 
            260                 265                 270         


Leu Lys Arg Asn Gly Asp Gly Ser Leu Leu Tyr Ser Val Val Asn Thr 
        275                 280                 285             


Ala Glu Pro Asp Ala Asp Glu Glu Glu Thr His Pro Val Asp Leu Ser 
    290                 295                 300                 


Ser Leu Ser Ser Lys Leu Leu Pro Gly Phe Thr Thr Leu Gly Phe Lys 
305                 310                 315                 320 


Asp Glu Arg Arg Asn Lys Val Thr Phe Leu Ser Ser Ala Thr Thr Ala 
                325                 330                 335     


Leu Ser Met Gln Asn Asn Ser Val Phe Gly Asp Leu Lys Ser Asp Glu 
            340                 345                 350         


Met Glu Leu Leu Tyr Ser Ala Tyr Gly Asp Glu Thr Gly Val Gln Cys 
        355                 360                 365             


Ala Leu Ser Leu Gln Glu Phe Val Lys Asp Ala Gly Ser Tyr Ser Lys 
    370                 375                 380                 


Lys Val Val Asp Asp Leu Leu Asp Gln Ile Thr Gly Gly Asp His Ser 
385                 390                 395                 400 


Arg Thr Leu Phe Gln Leu Lys Gln Arg Arg Asn Val Pro Met Lys Pro 
                405                 410                 415     


Pro Asp Glu Ala Lys Val Gly Asp Thr Leu Gly Asp Ser Ser Ser Ser 
            420                 425                 430         


Val Leu Glu Phe Met Ser Met Lys Ser Tyr Pro Asp Val Ser Val Asp 
        435                 440                 445             


Ile Ser Met Leu Ser Ser Leu Gly Lys Val Lys Lys Glu Leu Asp Pro 
    450                 455                 460                 


Asp Asp Ser His Leu Asn Leu Asp Glu Thr Thr Lys Leu Leu Gln Asp 
465                 470                 475                 480 


Leu His Glu Ala Gln Ala Glu Arg Gly Gly Ser Arg Pro Ser Ser Asn 
                485                 490                 495     


Leu Ser Ser Leu Ser Asn Ala Ser Glu Arg Asp Gln His His Leu Gly 
            500                 505                 510         


Ser Pro Ser Arg Leu Ser Val Gly Glu Gln Pro Asp Val Thr His Asp 
        515                 520                 525             


Pro Tyr Glu Phe Leu Gln Ser Pro Glu Pro Ala Ala Ser Ala Lys Thr 
    530                 535                 540                 


Ser Glu Gln Ile Asp Asn 
545                 550 


<210>  30
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  30

Arg Asp Pro His Gly Phe Phe Ala Phe Pro Val Thr Asp Ala Ile Ala 
1               5                   10                  15      


Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe Gly Thr Met 
            20                  25                  30          


Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser Val Thr Glu Phe Lys 
        35                  40                  45              


Ala Asp Phe Lys Leu Met Cys Asp Asn Ala Met Thr Tyr Asn Arg Pro 
    50                  55                  60                  


Asp Thr Val Tyr Tyr Lys Leu Ala Lys Lys Ile Leu His Ala Gly Phe 
65                  70                  75                  80  


Lys Met Met 
            


