                         SEQUENCE LISTING

<110>  AURIGENE DISCOVERY TECHNOLOGIES LIMITED
 
<120>  IMMUNOMODULATING CYCLIC COMPOUNDS

<130>  NP-92

<150>  1213/CHE/2012
<151>  2012-03-29

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  137
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(137)
<223>  Extracellular domain of human PD-1

<400>  1

Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
1               5                   10                  15      


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
            20                  25                  30          


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
        35                  40                  45              


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
    50                  55                  60                  


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
65                  70                  75                  80  


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
                85                  90                  95      


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110         


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
        115                 120                 125             


Ser Ala Gly Gln Phe Gln Thr Leu Val 
    130                 135         


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  BC loop

<400>  2

Ser Asn Thr Ser Glu Ser Phe 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  3

Ser Lys Thr Ser Glu Ser Phe 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  4

Ser Glu Thr Ser Lys Ser Phe 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  5

Ser Asn Thr Ser Glu Ser Phe 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  6

Glu Glu Thr Ser Lys Ser Phe 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  7

Ser Glu Thr Ser Lys Ser Ile 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  8

Ile Glu Thr Ser Lys Ser Phe 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  9

Ser Glu Thr Ser Lys Val Phe 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  10

Ser Glu Thr Ser Lys Ser Val 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  11

Ser Glu Thr Ser Lys Ile Phe 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  12

Val Glu Thr Ser Lys Ser Phe 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<400>  13

Ile Glu Met Ser Lys Ser Gln 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<400>  14

Ile Glu Met Ser Lys Val Gln 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  15

Ser Glu Met Ser Lys Ser Phe 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic Bridge

<400>  16

Ser Asn Thr Ser Glu Ser Phe Gln 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic Bridge

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  -NH-(CH2)5-CO- linked between C- terminal of Phe 7 and N- 
       terminal of Glu 8.

<400>  17

Ser Asn Thr Ser Glu Ser Phe Gln 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic Bridge

<400>  18

Ser Glu Thr Ser Lys Ser Phe Gln 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  -CO-(CH2)5-NH- linked between N- terminal of Ser 1 and C-terminal
       of Gln 8, which forms a Cyclic Bridge.

<400>  19

Ser Glu Thr Ser Lys Ser Phe Gln 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  -CO-(CH2)5-NH- linked between N- terminal of Ser 1 and C-terminal
       of Gln 8, which forms a Cyclic Bridge.

<400>  20

Ser Asn Thr Ser Glu Ser Phe Gln 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  -CO-(CH2)5-NH- linked between N- terminal of Ser 1 and gamma 
       C-terminal of Glu 8, which forms a Cyclic Bridge.

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  21

Ser Asn Thr Ser Glu Ser Phe Glu 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic Bridge between N-terminal of Ser 1 and gamma C-terminal of
       Glu 8.

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  22

Ser Glu Thr Ser Lys Ser Phe Glu 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  23

Ser Glu Thr Ser Lys Ser Tyr 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  24

Ser Glu Thr Ser Ser Lys Phe 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<400>  25

Ser Glu Thr Ser Lys Ser Phe 
1               5           


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  26

Ser Glu Thr Ser Lys Ser Phe Lys 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-Glu

<400>  27

Ser Glu Thr Ser Lys Ser Glu 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  28

Glu Glu Met Ser Lys Val Ile 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  29

Glu Asn Thr Ser Lys Ser Phe 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  30

Ser Asn Glu Ser Ser Phe Lys 
1               5           


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(8)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  31

Ser Asn Thr Glu Glu Ser Phe Lys 
1               5               


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  32

Lys Asn Thr Ser Glu Ser Phe 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  33

Ser Lys Thr Ser Ser Glu Phe 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  34

Ser Asn Lys Ser Ser Phe Glu 
1               5           


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(8)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  AMIDATION

<400>  35

Ser Asn Thr Lys Ser Glu Ser Glu 
1               5               


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Cyclic Bridge

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  AMIDATION

<400>  36

Ser Asn Thr Ser Glu Ser Glu Ser Lys 
1               5                   


