                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
 
<120>  Biomarkers for discriminating healthy and/or non-malignant 
       neoplastic colorectal cells from colorectal cancer cells

<130>  30932 WO

<150>  EP12162081.9
<151>  2012-03-29

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 201195_s_at; covers a part of the corresponding 
       human genome target sequence at the SLC7A5 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 16:87863622-87903125.
       Genomic location of design probeset-sequence as specified in this
       entry is 16:87863674-87864195.

<400>  1
gccagaacac cctacccaac ccagcccagt gtaacaggtt agccattaac acagaataaa       60

gaaggtccca gccacacacg tcattactcg gcagagggtg tccagcctgg tcggccgacg      120

tcacagtgga tggccctgcg tggctgggac acagacaggg agcaggcatg gcacctgcgc      180

cacgcagagc agcaaggctg agcatgacca ctggaaataa ataaacatgg tgccgacagc      240

atctttaaat tagtaagacg ttagcacaaa acaaaaaagc acaacgactg aaaatgcact      300

tgcttgttgt ggtgggttgt gcttgaaaac acctgaagcc cacaagtgga aaccgctggg      360

gacgtttgtc agtggagtgt ggagaaaaag ggacggaaaa atcaagtctt ctgagacagt      420

cccctgcggt ggccctggtc cctgtggaat tccagcacag caggaggggg agggggaagc      480

aggcctcagt cagcaccgcg ggacacggcc cctaccttct ga                         522


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify SLC7A5 subsequence, assay 103210

<400>  2
tacttcttcg gggtctggtg                                                   20


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify SLC7A5 subsequence, assay 
       103210

<400>  3
caggacggtc gtggagaa                                                     18


<210>  4
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SLC7A5 transcript-specific amplicon of assay 103210

<400>  4
tacttcttcg gggtctggtg gaaaaacaag cccaagtggc tcctccaggg catcttctcc       60

acgaccgtcc tg                                                           72


<210>  5
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the SLC7A5 
       transcript-specific amplicon of assay 103210

<400>  5
cttgggct                                                                 8


<210>  6
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 202859_x_at; covers a part of the corresponding 
       human genome target sequence at the IL8 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 4:74606223-74609433. 
       Genomic location of design probeset-sequence as specified in this
       entry is 4:74609017-74609379.

<400>  6
gtacccagtt aaattttcat ttcagataaa caacaaataa ttttttagta taagtacatt       60

attgtttatc tgaaatttta attgaactaa caatcctagt ttgatactcc cagtcttgtc      120

attgccagct gtgttggtag tgctgtgttg aattacggaa taatgagtta gaactattaa      180

aacagccaaa actccacagt caatattagt aatttcttgc tggttgaaac ttgtttatta      240

tgtacaaata gattcttata atattattta aatgactgca tttttaaata caaggcttta      300

tatttttaac tttaagatgt ttttatgtgc tctccaaatt ttttttactg tttctgattg      360

tat                                                                    363


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify IL8 subsequence, assay 103136

<400>  7
tagccaggat ccacaagtcc                                                   20


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify IL8 subsequence, assay 103136

<400>  8
ctgtgaggta agatggtggc ta                                                22


<210>  9
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL8 transcript-specific amplicon of assay 103136

<400>  9
tagccaggat ccacaagtcc ttgttccact gtgccttggt ttctccttta tttctaagtg       60

gaaaaagtat tagccaccat cttacctcac ag                                     92


<210>  10
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the IL8 
       transcript-specific amplicon of assay 103136

<400>  10
ctgtgcct                                                                 8


<210>  11
<211>  433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 204470_at; covers a part of the corresponding human
       genome target sequence at the CXCL1 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 4:74735110-74736959. 
       Genomic location of design probeset-sequence as specified in this
       entry is 4:74736466-74736898.

<400>  11
tatgattaac tctacctgca cactgtccta ttatattcat tctttttgaa atgtcaaccc       60

caagttagtt caatctggat tcatatttaa tttgaaggta gaatgttttc aaatgttctc      120

cagtcattat gttaatattt ctgaggagcc tgcaacatgc cagccactgt gatagaggct      180

ggcggatcca agcaaatggc caatgagatc attgtgaagg caggggaatg tatgtgcaca      240

tctgttttgt aactgtttag atgaatgtca gttgttattt attgaaatga tttcacagtg      300

tgtggtcaac atttctcatg ttgaaacttt aagaactaaa atgttctaaa tatcccttgg      360

acattttatg tctttcttgt aaggcatact gccttgttta atggtagttt tacagtgttt      420

ctggcttaga aca                                                         433


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify CXCL1 subsequence, assay 105522

<400>  12
tcctgcatcc cccatagtta                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify CXCL1 subsequence, assay 105522

<400>  13
cttcaggaac agccaccagt                                                   20


<210>  14
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL1 transcript-specific amplicon of assay 105522

<400>  14
tcctgcatcc cccatagtta agaaaatcat cgaaaagatg ctgaacagtg acaaatccaa       60

ctgaccagaa gggaggagga agctcactgg tggctgttcc tgaag                      105


<210>  15
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the CXCL1 
       transcript-specific amplicon of assay 105522

<400>  15
ctcctccc                                                                 8


<210>  16
<211>  2760
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 205828_at; covers a part of the corresponding human
       genome target sequence at the MMP3 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 
       11:102706532-102714534. Genomic location of design 
       probeset-sequence as specified in this entry is 
       11:102706594-102709353.

<400>  16
gtctgttgca cacgagtgct tccccttctc ttgggaaaga tcactctatg tgacaaggtg       60

caagctaagc agcagcccat ttgaatgccc tgtaataaca taaaaatgac cggcaagata      120

cagattcacg ctcaagttcc cttgagtgtg actcgagtca cagcacaggc aggagaaaac      180

gaacatttca attcacagag acttaggtga agaattatta gcttcattta aagtgcccat      240

attgtgcctt ctacatatct ctttcaacaa ttaagccagc tgttactctt caaagtgtgt      300

gtcactttct ttgcatttgg gtcaaactcc aactgtgaag atccagtaaa gaaataaaag      360

aaccctgcaa atacagacaa gggaaatagt aagatatttt tccaaataaa gacatttgac      420

aatatacaaa actcagaatc atagagaact aaaaatagaa agtgtttata gagctttact      480

ttatgtcagg gactatgcca agcttgttac atgaatttat tttcatttat ttctgcaaca      540

accctatgag gttgtatgtc taactccatt tacagattga gcaagttgag gttgagacag      600

atttcgatgc ttcctcaagg ttactcagca aggaagaatg gagacagcac tcggtgccag      660

ctctgtctga aaacacagcc agattccagg ttacagggtt attctgcttc cgatcagata      720

aattctccac ttgcttggaa actctcatca cctatttctt tcttccccaa aaatcctcct      780

cccttttccc tgcattgcag cctaggaagc acagcaacta tttcaaaaca ccaggggacc      840

ctttagtgct ctgcaaacat ggtgatcagg ttacctttca ataaagatca tcagcctcca      900

cttccttacc ttgagtagaa aacaaaatct tttttttttt ttaaactttg ggcacatgga      960

aaggtaagta tttgcaaatg actggcatgg gcaatgactg acaactcagg aaagacagac     1020

aaaaaatctc cctgggaatt agtagcagca ataagatagg gtggaggaga aggccagcta     1080

accaacatta aacctggcca caccacttga tgggattttt atgctaacat ggtaatctga     1140

aagtcgagct tgactccaca tgttagctcg agatgtaagt gacactggag cactttgatt     1200

ttatatgcat gtataagata aagtagcgag atttgtgtaa ttatctttat ggttccaaac     1260

aagttatttt gtgaagtagt tctataatga gtacaaatgt aggcgaatca aaattttgag     1320

aagggaactg gccctaagaa acacttgtta ttaaaaagtt tcaatgctcc tcttccctct     1380

gatatcataa aatgtttcaa gtgctctatg gccaacacag taagtatcct cttaccaaat     1440

tcttcaaaaa cagcatcaat ctttgagtca atccctggaa agtcttcagc tatttgcttg     1500

ggaaagcctg gctccatgga atttctcttc tcatcaaatc tgtaccaagt aaaagaaaca     1560

gctcagcatt gcatagaggc catgttaccg aacatcttag atcatgttag gtttaatgtg     1620

gaattttact aaactttata aatactgcaa ataaatgcca agcatatttg ggactataga     1680

aatatgtgac tttaatggta ctgtaaagag ttctgaaagc catatctcca tccggaacag     1740

gggccgcatc ctgctgtatg tagcacatgc tgtttgtcat catatttctt aagcctggac     1800

agaaagaacc ttaatcatct ttctgtcaca aagacatgaa agtgtgaaca tatatataaa     1860

gtgaattgaa tcaacatcta aaatgcaatt ttaattccct accacaattg gcccatatat     1920

gcctgctgtc ccctcccctg cacatctaaa tcttctctgg tggcctcctg ggaaaaggga     1980

ttaggataag aagcaaagca cagtaagtgt gtttttagcc cattggctgg atatcagatg     2040

gtcggcctcg atgtctcaaa gtctggccaa atgacccagg aatcaacctg tctgtgagtg     2100

ttgggttgta tccataaact ggactgctat tgatcatcat ctcttaaatg agccatcatt     2160

atcaggtaga ggtgacaagt gggtgaggtt agaggtagcc cttgaaaatc atatagtagt     2220

gttaggaaga caaaacaaac acacaatgag acagtgacaa acacacagtg agacagtgag     2280

ccaaactaaa agacaatggg aagggaacgc taaattgcgg tctgggttct cagaacattt     2340

tcccaatggg tctaaagtcc acgagggaaa gctgcatgga ggtgatgaga cttgagccag     2400

gacttgaagg atgggcaaga tttgaatagg ttgaggagag aagagggggc tccaggcagg     2460

tggggtgaca gcaccaaggg aagcaccagc caactgcact tgggactgaa agcaggagag     2520

cctaaggtgc tgctgtttta aagtaagaac tttcccacag ttgtctgaag tcccatcctt     2580

cctactaaga gagaagcagg cctaaggttg gggtggggga tttccttagt aaaagaaact     2640

aatttcccta attaggctcc atacaaagtc atttctcttg catctcacct ccagtatttg     2700

tcctctacaa agaaatatgt tttgttcttt tccttatcag aaatggctgc atcgattttc     2760


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify MMP3 subsequence, assay 103167

<400>  17
ctccaaccgt gaggaaaatc                                                   20


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify MMP3 subsequence, assay 103167

<400>  18
catggaattt ctcttctcat caaa                                              24


<210>  19
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP3 transcript-specific amplicon of assay 103167

<400>  19
ctccaaccgt gaggaaaatc gatgcagcca tttctgataa ggaaaagaac aaaacatatt       60

tctttgtaga ggacaaatac tggagatttg atgagaagag aaattccatg                 110


<210>  20
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the MMP3 
       transcript-specific amplicon of assay 103167

<400>  20
atggctgc                                                                 8


<210>  21
<211>  533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 207504_at; covers a part of the corresponding human
       genome target sequence at the CA7 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 16:66878282-66888056.
       Genomic location of design probeset-sequence as specified in this
       entry is 16:66887439-66887971.

<400>  21
ttctcaaggg cttccatgtc agcagacacc aaaccatctg aggcttcctc cctggggggt       60

gctggggacc ctccttcagc cagtttgctc cttggtcacc ctggaggctt ctggatggga      120

cccttgagtc tggggcaccc ttcagctgcc ctggggacag gaaggacagg agctaagcag      180

ggtccaagcc tggggctgcc tctgctctcc aagacccaaa gaccctggga acctcctctg      240

gtcttcccca ctggcagtgg cagcagcccc accccgagcg cacactgtga tggaggagac      300

tgagctccct ggggcgggca gctgacacta ccagagagac tcaagcaata attagaggtg      360

ggcagagctg ccctctcggc attacctctt ctgcaggctc tgccatgcac gcacctcact      420

gccaggccat taaaatcagc acccagcatg ctggaggtga cgtggccttc tccctccagc      480

cacctgctgc cacgggcagg ccctggctat agcttataca gtatctcccc ttg             533


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify CA7 subsequence, assay 103015

<400>  22
agcacgatgt gggttctga                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify CA7 subsequence, assay 103015

<400>  23
ggcattccag tgaaccagat                                                   20


<210>  24
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CA7 transcript-specific amplicon of assay 103015

<400>  24
agcacgatgt gggttctgag cacacggtgg acggcaagtc cttccccagc gagctgcatc       60

tggttcactg gaatgcc                                                      77


<210>  25
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the CA7 
       transcript-specific amplicon of assay 103015

<400>  25
cttcccca                                                                 8


<210>  26
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 209395_at; covers a part of the corresponding human
       genome target sequence at the CHI3L1 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 
       1:203148059-203155877. Genomic location of design 
       probeset-sequence as specified in this entry is 
       1:203148115-203148381.

<400>  26
gataggggac acgattacgt tcctaagtga aggtttcaag ctgggctttg cagggggtat       60

aattagtatg gtcactgtgt cttgtaggat gtttggctcc ttggtgatag agcttgccaa      120

aatggtgtcc tttgataagg agggctgggg ggcagggagt tgaagaaatt cccttgccag      180

gcttggggat ctgtaaacat ttccattaat caacaagtgt gtactaatcc cgagtcttac      240

attgcgatgc ctcactatcc ccacagc                                          267


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify CHI3L1 subsequence, assay 103035

<400>  27
cccaacctga agactctctt gt                                                22


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify CHI3L1 subsequence, assay 
       103035

<400>  28
tgttggaggc tatcttggaa a                                                 21


<210>  29
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHI3L1 transcript-specific amplicon of assay 103035

<400>  29
cccaacctga agactctctt gtctgtcgga ggatggaact ttgggtctca aagattttcc       60

aagatagcct ccaaca                                                       76


<210>  30
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the CHI3L1 
       transcript-specific amplicon of assay 103035

<400>  30
catcctcc                                                                 8


<210>  31
<211>  547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 39402_at; covers a part of the corresponding human 
       genome target sequence at the IL1B locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 
       2:113587328-113594480. Genomic location of design 
       probeset-sequence as specified in this entry is 
       2:113587361-113587907.

<400>  31
cattgaacag tatgatattt gctcatttat aaatattccc atttaaataa tctgagctta       60

tatattttca gtcttaatta aaggacttga tttaaagaga gcacaccagt ccaaattgaa      120

ttgattccat agctattaaa aactaggctc ttttacagac actgctactt cttgccccct      180

ttgaataaat tagaccaatg aataaaacaa acaaacaaat aaataaataa atagggaagc      240

ggttgctcat cagaatgtgg gagcgaatga cagagggttt cttagaacca aatgtggccg      300

tggtttctgt caggcgggct ttaagtgagt aggagaggtg agagaggcct ggctcaacaa      360

aagggctggg gattggccct gaaaggagag agctgactgt cctggctgat ggacaggaga      420

tcctcttagc actaccctaa ggcaggcagt tgggcattgg tgtagacaac aggaaagtcc      480

aggctatagc cgtactcaaa aacctttctg ttccctttct gccagcccta gggattgagt      540

ccacatt                                                                547


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify IL1B subsequence, assay 100950

<400>  32
agctgatggc cctaaacaga                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify IL1B subsequence, assay 100950

<400>  33
tcggagattc gtagctggat                                                   20


<210>  34
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1B transcript-specific amplicon of assay 100950

<400>  34
agctgatggc cctaaacaga tgaagtgctc cttccaggac ctggacctct gccctctgga       60

tggcggcatc cagctacgaa tctccga                                           87


<210>  35
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the IL1B 
       transcript-specific amplicon of assay 100950

<400>  35
tccaggtc                                                                 8


<210>  36
<211>  32767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 209774_x_at; covers a part of the corresponding 
       human genome target sequence at the CXCL2 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 4:74962793-74965010. 
       Genomic location of design probeset-sequence as specified in this
       entry is 4:74736327-74963999.

<400>  36
agagagacac agctgcagag gccacctgga ttgtgcctaa tgtgtttgag catcgcttag       60

gagaagtctt ctatttattt atttattcat tagttttgaa gattctatgt taatatttta      120

ggtgtaaaat aattaagggt atgattaact ctacctgcac actgtcctat tatattcatt      180

ctttttgaaa tgtcaacccc aagttagttc aatctggatt catatttaat ttgaaggtag      240

aatgttttca aatgttctcc agtcattatg ttaatatttc tgaggagcct gcaacatgcc      300

agccactgtg atagaggctg gcggatccaa gcaaatggcc aatgagatca ttgtgaaggc      360

aggggaatgt atgtgcacat ctgttttgta actgtttaga tgaatgtcag ttgttattta      420

ttgaaatgat ttcacagtgt gtggtcaaca tttctcatgt tgaaacttta agaactaaaa      480

tgttctaaat atcccttgga cattttatgt ctttcttgta aggcatactg ccttgtttaa      540

tggtagtttt acagtgtttc tggcttagaa caaaggggct taattattga tgttttcata      600

gagaatataa aaataaagca cttatagaaa aaactcgttt gatttttggg gggaaacaag      660

ggctaccttt actggaaaat ctggtgattt atatcaatat ttctcaattt tttaattgtg      720

tttatttttc tgggtgttca atttgctata cagataaatc aaactatgag ttatgcttca      780

tttcatgcgg tgattgctgc caataccctt ggctctcacc tagtgaagaa tgcgctttac      840

taaactatgg gctggcccct aatgggagag tcactgatat aaattgccct ttttataaga      900

agtttctttc tgtcttgcta ctcaaattta cctccttaaa aatatttata ttatcttaac      960

aagggctctc atttcattgc ttttgttgaa caatatttct cataattgtt gacaatttaa     1020

tgaagctggc agtgaaatgg tggctaaaat atttcgtttt tcaaaactca aatcatttgt     1080

gtcgtcaata gaagcaaaag tgagtggctg aatgcttcac ctgtgaaaag atctgattga     1140

aatttgggct cagctttcta gccttcacat ataagtaatt agcactaaga tttgcggtgt     1200

ttcaatcctt tatagcaata taccaactat aatggtttta agattggact gcattcattt     1260

gcatcgttcc tagtggaatt ttgatgggac ctcatagagc ggttgccttc tggggaactc     1320

tgtattcaat gctgtcccag aacagcagca gcactacagg tttttaggac agaagcaaaa     1380

ttggcatgtc taaggaagaa ataccccaat aatataaaag aaaccacact ccaaacctga     1440

aaaggaagga tgttcgtgca tgcatgaggt gtgtgcttgt ttctgattca gaactcattc     1500

agaaatcctg agccctgggt aactgcctct aacagaggca agaaggtgag actggcagcc     1560

tcaatacttc aaatcaaatt ctggatcatc ccaagaagct gggcaaatag aggtcataag     1620

caacaagaaa caaactctgt gagcttttct cacaactaaa aaagttaaaa acaagaatct     1680

cttcataatt ccaacattat tagttaatta tgaatgagat gaggaagaag aatatttgta     1740

aactatacat aagcaaataa atgcaaacca tttgagaaac tccataaatg gtagcattca     1800

ctccctaacc ccaagttaga ggacactgga aaatgtttac aagtagcatc caagggttca     1860

ataaaaccac tccttacacc taagacaagt ccttaccctc aaacattgga gcttgctgta     1920

ctggctacct agctctggct aatatggaac agggaacata aaaaggacaa aagagatgct     1980

tttattcaca tggtggttaa agacagattt caaaggatca gattgacttt ggtgtaaatt     2040

ccagctctgt cactgtgatc ttgggcaagt ttctttactt cactcaacct cattttcctt     2100

tctataggat gaggataata aaattagcct tctgaagtgt tgtaagaatt aaatgttatg     2160

gaggctctgg aaacctggtt cttgccattg gtcctcaggc caactccatg gacatggtct     2220

cagtctcagt cttagatcaa gcagatatgt aaattgtgtt ttcacaccaa attgctctga     2280

aaacttgcaa gtacaaggca gtctcctgtt gggagtgtta tagcaggaag taggatacag     2340

cgtttttggc gtggtagtca cagggtgaag gaagtaggaa aaggatatta cataacacat     2400

cacagttttg agaagccatc agcaggaaac agcaatgatc acagtgactg aggtttcttg     2460

agcaatgtta ccatggggtc tagagaagga aagaaggaga cgtggctaac gctattctat     2520

cattgtgagt cctcctgaga caccctctca ggtgttccag aagtaactgg agagacgtta     2580

agggatggtg gaggtggcag acccacaata gcacagtgag ggaaatccag aaaaacagat     2640

cacacagttt gtcttttctg gctacccaat cacataattt aaaaaaggac ctgcctgtct     2700

tcaccaatga tgtcccactc ccctcacaat gagtacaaca gctgcaatgt ataacagctt     2760

cccaacttaa ggcacttgtt cttctgcatc tcttcctggg ggcttcctcc attgaggtgt     2820

gggaaagggg gcttggcaga gagagatttc tcagcccaca gctaggatgg cctgtgattt     2880

gatgccctga gaggagagat aggagttaaa ggatgaatat tcaattttcc cagtctcttg     2940

ttagataatt ctagaatttc ctatctctct ctccatatat atgtgtgtgt ttaaatttta     3000

tagatagtgt attaaaataa ataaatatta aaaagacata tgaatagatg aaatgttcca     3060

cttccctctt cattatgttt acaccttctt tacacacctg agcataatta agatagttat     3120

tttaaaatct tggtatgcta agtctatcat tctgtcactt ctgaatctat atttacttga     3180

ttttttttct cttatataac tcatgctgtt ctacttctta gcatgtataa tcattttcat     3240

ttgactgcag gaaattttga atcttatgtt gctgagtgtc aagatttgtt ctctttcttt     3300

agagtcttgg gctccatttt gacaagcagg taagttctag ggcatcagct ttgtctcttt     3360

ggggcttgtt gttgagcttt gttagggtgg tctaggaatg ttcttcactc tagggtttgt     3420

ttagctgtac tactaagtca tgtccttctt gtgccgttag tgaatgccct gagtgctcac     3480

aggttctctc tactacgaca gggtagacct taactatctc ctcattccat gctaggtctg     3540

aggttttctc agcttacaaa tctctagtta ctctttgctt gacttatgga gtttccccca     3600

ccgtgcgtgt gtgacttagt actgatcaaa gagacccagt gggacctcag tgcagattta     3660

tggagttctg gtttcttgca tagatctccc ctttctacaa ctcttttttc ctaaacttct     3720

agccacccca gctcccttga attcaaacct gtgccccctc aactcagtaa gactaccatg     3780

gtctactttg gatctctccc cttgcacggt ggtccagagt tgctccagaa aaaaaccaag     3840

atcaccatac acctcacctt gtttatttcc ttttctgagg aattctagcc ttttgctgct     3900

tgttgtccaa tgtctgataa caattgcttc atatattgtg ttgcattttc tagttgctta     3960

agacaggaag ttatgacttc tgttttactt caacgtgact ggaaattgaa gtcttattgg     4020

gacaattctg aggaacattt tacaaggttt ccttgagact ccatggcaag atgaagccct     4080

ggttgcacaa atgatagctc attcattaca tacactttat tagattttct ctcttcccta     4140

tcccacattc ccccactcct tcacttgttc tttccatgat cacctgtaag ataaactact     4200

gcgcataagt cttttatcag actctgtttt gggggagccc aaacttagac agttgggccc     4260

cccagaaatt agacctcata gcagaggctt atgactacta ttttattgag gagtataatg     4320

ccagaaaacc aagaggaaga aaaatgggaa gtgaggcaga aacaagtgaa agctcatgat     4380

agaagagagc agaaccacac tggccattgc tgcacacaac tgagttcttg acctcacaaa     4440

ggggctgttg tgagtgtttg ctttcctcat ctgcagaaac tatgaaacct gctcaaacca     4500

agaaattgta gttgttgtgt ttatagcaga gtcataaatc ttcctaacag cagggcatca     4560

gcctctgatt tctattcctt ggctatgctt aaaataaaaa tgtggaatct ggatccacaa     4620

ggtactaaag cagggagaaa gagtctacta aaccatagtc aggacctcat tttcaccttt     4680

gaaaaggtga ggactccaac tgacattttt gttctccaca ttaaaagtaa taaatctttc     4740

tttttttaag tgaaaagtag ttagaaatgc tactgttgct ttcaagaatc tcctaaaaaa     4800

gaagccagat catatggtga gaaataaata aataaaatgt tgagactagg gactgatccc     4860

ttgacagcca gacaggagtt tggttcaaaa cttgagagat cacaagaaaa agaaaatcag     4920

ccttctcatt ttatagatgg aactacaaag gctcagaaac caccaaggag ttaccaaatg     4980

ccatggaatt attttattac aaaagtgggt cagagtttgg ttttctgatg actaatacac     5040

agtgattttt attaaactag attattttca tgactgctca agaagacagt tatcctaaat     5100

tttggctaca ggattggctt tctaaaattt gtagaaccat tctcagagta ctaattaata     5160

gctaatagcc attcacgcca tgtgccactt taagaaagtt taaagaaaac attgtgcata     5220

ttgtagccaa ataattcaaa gtataaaatg agttcagcca atttactggc taaattactc     5280

tattaatcat ctattgtctc ccgaaaatgc agtgggttta aacagtcacc attttatttt     5340

gacacatgac catcaatttg ggctaggcaa tacaacaacc tgggcttggc tcaggtagtt     5400

cttctgatgg tgtctcctgg agtcaccagg tgacacttgg tgaccgagtg cagctgcctc     5460

actcacatgt ctggtttttt gcactagtca ttgcctgggc ctcatgagct tggctatcct     5520

catatggtgg cagctgcatt ttaacagagc aggggtagaa actcctaggc ttcttacctt     5580

gttggcctgg aacatctaca tcatcacttt taacacttcc tattggccaa agcaagtcat     5640

gaggtgagca tagagtcaag ggggttggga tacagattct gtctcttaaa gtgaggagct     5700

gctaagaatg taaggctatt tttaatcttt cactgctgta ttacttccta atatttgatt     5760

ttcttgttta tgacatagaa ataccccttg taaagtttcc agaaaactta caaaaattca     5820

tagaggaatg ttagcacaaa tgtttattgg agtacaataa acaattatta ttattatatt     5880

acattgcatt tcagtgtaga taaatatttt aaaaaataaa acataggatt acagttaaaa     5940

ttggatgttt tggtaacttg catatttgta taagcctcag gcctatgtga aaattcaact     6000

aacaaaataa ctgtttataa gatcagggaa gttgtcaagt tgtcagtctc agcactctaa     6060

atctaactgt aataagttct gctgcagatc tggcataaat tttagtagct gtagaatgag     6120

agaaccatct ttgataagaa aaattaccat ctctttaaca aactccttag taaactattg     6180

tgatgtctta agtctgtctt tgaagtttta tgaaaaacta aattacttcg aatctttcaa     6240

tacttggtta tcttatctgt atatactttc ttattagcat cataacacct gtacagattg     6300

atagcacatt tttttatttt tttttaaatt ttattattat tatactttaa gttttagggt     6360

acatgtgcac aatgtgcagg tttgttacat atgtatacat gtgccatgct ggtgtgtgat     6420

agcacatttt attaccttta cttggtacag aagaaaaatg agatttgaag aaatccaagg     6480

ttgtttctga ataacagttt gaagttactt gcagcttttc atttctacaa aggacaagat     6540

gtgatcagtc aattgaatgt tgtcaggttg ttaaaacatc tcatttaaag actgaaatag     6600

ctttttcctc cttccttaac atgcccatgt cttgtttgtg cttctttgtg catttctctg     6660

tctcaaacgc ttatcagcct tcaaaaaaga aatgatgact ttctttttgt cttttcacca     6720

gtccagtgtt accttccctg taaagtcttt cctgacggcc ctggggaagt cctccctccc     6780

ctctgcttcc actatgcctc agatatacaa ctgttataac acagaccacc ttttagttta     6840

atctgtttac tcatctgtct ctcaaaacag actgtgaacc tcttaagagc agaaattcaa     6900

ctttcattat cttcaaatgc ctagcatcaa gcaaaggccc tcgcaaataa taaatgctca     6960

attataatcc gtaaaagaaa ataacttact atttaggcta gttttagctt taaactgtat     7020

caacctttca gtaatcacta gttcttcagt taaatgttgt tataggttga attatatccc     7080

cctcaaattt atatattgag gtcctaatcc ccagtacttc agaatgtgac cttatttgga     7140

agtagggttc ttaaagaggt aattcagtta aagtgaagta attagagtga acccctaatt     7200

cagtatgatt ggtgccctaa taaaaagggg aaatttttag atagacatgc agacaaagag     7260

aacaccatgt aaacataaag atgaacaccc gctaagcaag taaagatgtc tggaacaact     7320

ccttctctca cagtcctgag aaagaaacaa ccccattaaa cctacatttt gggcttccag     7380

ggtccagaat tgaaatatga aaacatttct gttgtttaag caacccagtc tgtggtactt     7440

tggtatgata gccctaggaa actaatacaa atgttttggt ctttgatttg ttaatacaaa     7500

aaaaaatgtg gtcactatga tataatcaaa gtcacttata aaactgctta agaaataaaa     7560

ttaaagctca tagttcacta ttagataatt aaccttgaag ccaatggaaa ctgctgcctt     7620

caaacaataa gtaaagtgtt gtttgcagtt ctttttaaaa attatgtatt tattactttt     7680

ctttaatgcc atgaaaaaga taacagacca gattatcttt atactttaaa taattaaaac     7740

acaaaatata tgaagtgatg gacattagac aataggaata atgggatagt aatccctgca     7800

agaaaaaaaa aaatcagagg caagcccttc catggcccca gagtaccaca tagagagcat     7860

ttccagaaat catcattgaa agacaaagtt cagagttcta tgttgttgtt gtttgttttg     7920

ttttgctttg aattattttt ttaaattttt actttaagtt caagtgtaca agtgtacatt     7980

tggtacatgg ctaaactttt gtcatacaga ttatttcatc acccaggtat taagcctagt     8040

acctattaat taattttcct gatcctctcc ctcctctcac cctccatcct ccaacaggac     8100

ccagtgtgtg ttgttcccct ctgtgtgtcc ataagttctt atcatttagc tctacttata     8160

agtgagaaca tgcagtattg ggttttcagt tcctgtgtta gtttgctgag gataatggcc     8220

tccaagctcc aaccatgtcc ctgcaaagga catgatctca ttgtttttta tggctgccta     8280

gtattccatg gtgtttatat accacatttt ctttatccag tctatctttg atgggtattt     8340

aggttgattc tatgtctttg ctattgtaaa tagtgctgca acaaatatac atttgcctgt     8400

gcctttataa tagaataatt tgtatttctt ctggtatata ccctgtaatg agattgctgg     8460

gtctttaggg ctttgaggaa ttgctgcact gtcttccaca atggttgaac aaatttacac     8520

tcccatcgac agtgtataag cattcctctt tctccatgac atcgccagca tctgttattt     8580

tttttctttt caataatagt cattctgact ggtgtgagat ggtatctcat tgtggttttg     8640

atttgatttt ctctaatgat cagtgatgtt gagctttttc catgattgtt ggctgcatat     8700

atgtcttctt ttgaaaaatg tctgttcatc tcctttgccc tttttaatgg ggttgtttcc     8760

ttcttgtaaa tttgtctaag ttccttatag atggtggata ttagagcttt gttggatgta     8820

tagtttgaaa aaaatttctt ccattccata ggctgtctgt ttactctgtt gatagtttct     8880

ttcactgtgc agaagctctt aagtttaatt aaatcccatt tgtcaatttt tgctttgggt     8940

gcaattgctt tcagcatctt tgtcatgaca tctttgccag tgtctacgtc ctgaatggca     9000

ttgcctaggt tgtcttcccc aggatgttta tattttggga ttttacattc aagtctttaa     9060

tccatcttga gttaattttt gtatatggtg taaagaaggg gtccagggtt aatcttctgc     9120

atatgaccag caagttatcc tagcaccatt tattaaatag gaagtccttt tcccattgct     9180

tgttcttgtc aagttggctg aagatcagat agtggtaggt gtgtggtctt atttctgggt     9240

tctgtattct gttccattgg tctatatgtc tgtttttgta ccagcaccat gttgttttgg     9300

tttctgcagc cttgtaacat ggataacagt tggatagtgt gatgtctcca gctttaatct     9360

ttttgcttag gattgccttg gcaattcggg ttcttttttc gttccatata aattttaaaa     9420

tagttttttc tttctctgtc aagaatgcca atggtagttt aatagcaata tcattgaacc     9480

tataaattgc tttgggcagt atgaccattt taacattatt gattattctt atacatgacc     9540

atagaatgtt tgtccatttg tttgtgtcat ctctcatttc tttgagccat gttcagtagt     9600

tagttatcct tgtagaaatt tttcacctcc ctagttagct gtattctcag gtattttatt     9660

cttttgtggc agttgtgaat gggtgtttgt tcctgatttg gttctcagct tgaccgatgt     9720

cgttgtatgg gaatgctagt gatttttgca cattgatttt gtactgagac tttgcataag     9780

ttgtttatcc acttaagaac ctattggact gagactatgt cattatctag atataggatc     9840

atgttgccag tttacatttc ttgacagcaa catggttgta atctgaactc catttttctg     9900

caggatatta agctgtatgt gtacttcagg tttgaccgac tttattaaga ccttaaatgg     9960

gattatgcaa atacaaaagc caacagcaaa tacttcctga ggaaatgcat cttaattccc    10020

tactttgtac aaacatgttc tttgtaaaca tgcatagaca ttctcatgac tccattctac    10080

cagtcaccat taactgcaac cgacatcgat cccttcacaa ttatgcagtt tcacccccag    10140

aaaataatac attcatttct ctatttaaca agttcatctt agcgtgcccc caaagcccca    10200

attaaaacaa tacttgaaaa acaaactcag tttccttgct ggcttgtgag tgacaacatg    10260

aggctcaata aactgtacct tttattcttt aaccaagaga gtgcaatgag agtaataaaa    10320

aagttctcag cgttgcagag agcacataaa agtgggctgc agtattgatt ccaccagaat    10380

caatctggat cttgatccag accaggatca agatcaagga tagacctggg tactcaggac    10440

tcctccagca ctcctcctgc tagctgtcat tgttctgggc acatttggta agccaactgt    10500

ggcttttatc ttttccttct aggcattaga aaatctcaga aaatattcca gatgtaatga    10560

gattgtattt ggcattaaga aaaatgtaaa aactgtgaaa ttgaaactta agctgacata    10620

tacagtattt agactatgga gtgtcaaaga cttcttgttg agtcaaataa aaacatctgt    10680

ttaacttcct agaaatatct gagtgtaaga gtctgtgctt ttcttattat agatgatagc    10740

aggaacgtta ccaaaaattg gtttacgatg ttcattttaa tgatggtaag cagagagaaa    10800

atgctaattt caattaataa aattcacata taatctttat gtttacaact tttggtagga    10860

aggatcaagt tgatttttgc cattgaaaaa gttatcttat tgaccataca tacttgaaag    10920

caataaatta tcggtctagt atatctacca gtttttcaag cataatagat gctcaataat    10980

tgtttgttga tcaggataat aatatgttat taataattat gtttgtgtaa ctgtcttcat    11040

aaacatttct atcagtactg aatttgtgaa tacagttgag tgtccttcta tattgatttc    11100

tactttaaag taaagaagta agcatcatgg ctatgtttgt tctcaataag gatttttcta    11160

atttttttct cacacagctg attcctctga ggattaagag ttggatgtca gtgtattcag    11220

acacattctg actttattcc tcaccaattc attaaaaatg atcagttgat acataaggat    11280

cctttctgca gaagaaaaga agtcagtaag tagtgaagat gtggtggagt ttggaagcct    11340

ctaggacagc agttttcaaa gctggcattt ccttacaaag tatgctaggt tggaagtata    11400

ggagatctaa cctctaggtg ttattcctat gcaatgtggg aagataactg cccaatcttt    11460

atgctttcat tcctgaaaac attatctact ttccccaata aaaagggctc tcaaatggga    11520

acatagggta tgaattcatc tgagtggagt taaccctata gtcagtgaac atgtaccata    11580

agcaaagata cacattcctc agtaaggata catggataat tagttgatca tcaggaaatc    11640

tattacaaac ttagttatat gataaattca gtatggccag atggccatgg agacaactga    11700

ggcataagcc tacaaataaa gagcttagag actgtggaaa acaattctgc attttattaa    11760

aaaaaatttt actataaact atgtttgcca gattgtttca ggtgttcatt gccaggtaat    11820

gaattaccac aatttagtgg cttaaaatta acccacttat taattttcac agtttcatag    11880

ctcagtaatc taggtggctt caccagtttc tctgcttggg gtttcataaa gtcaaaatca    11940

aggtgtcagc taaagtctca tgcgaagact ctaaggatgc aatccactgc caatccaggt    12000

tgttggtaga attcagttct ttgcagtata agactgagct cttcatattc attttatctc    12060

tcaaaaattc taatgaatta atttaaagca ttgttaaatt aagcatagtt attatttagc    12120

cagaacattc ttttcttttc agaaccacac tgaaagatgg gaaaataatt tcttcggatc    12180

cctgcatatg tgcatctgaa catgggagag agaaaaataa agaggggcag acagaaaata    12240

aaacacatct cctcagaaga aacaaactgt tagtctttag agtggtgata tgtatatatt    12300

gaaagagaac tagacaaaaa gttcagacgt ttgggctcta tgattctgag caagcatctg    12360

agcttcttta tactcagttg taaatgttaa aacatgggaa aatgaaacaa aacatctcct    12420

ccttgacaaa actgtcaaga ggagataata aaattgaaag tgctttgaac ataaacatga    12480

aaaatcagag tgttgttctt attaaaacta tgagatcact tcttaattag tacttagaaa    12540

agcaagtttt gtggaacctg ttcacattgc cctatccata actacatatg caccaaacca    12600

ctaaattatc tgtagcaggt gccaagtttt actgctgtag atcatagcaa aaatgataat    12660

agttattaag ctgtatacta acaagtacct ctgagattga gctctgtgaa aaaaaaaaat    12720

ccatctcagg acaacaagtt caagaccaag tactttagca cataaaattc caaatttctg    12780

gggaaaggga tccagttagc acagtttgag tcatgcactc actcatggtc tacccctctg    12840

tgggcaggaa atgagaaaca caccacagag acatggctgc cagaagtcct cccagggtga    12900

ggcaggcgat tcttggagta acagacagac atctcagtgg gacctcccta ccactcagag    12960

agcattcttc ttaaatctga gggaagagta aataactgtg ggtacttttg gtttcagaag    13020

gatttttttc aggggtaaag ggggagtgat aaaaataacc tgaaaacctt taaattacaa    13080

gtcacctaaa acactgacta tggaaacaat tcttttaaat gaatagctta gctctctaga    13140

aagtagtaaa aacccccagg acctcaaaaa agagcaatca gaaaatagga caagaaattt    13200

cataggttag tgccatggat tgtgcagagt aaggcttgaa gatggttgct ccatcagtaa    13260

cctagatgtt gacattttta tctcacgtta gaacagaaga catggctgtg gatccttgta    13320

agacagagag ttgtaacaaa ggtccttgta taaaatcaga accctcaata gaaataaatc    13380

tactaaaaac actgatttac aataaggagg catgtttgtc ttaacatgaa caacaggttg    13440

aagaaaaaac aatttcttga gaaattattt gggattctgt tataacacct gtttgggctt    13500

ggaacccctt ggtaccatag aaggaggccc agatcaatac ctggcagaaa tgaaactaaa    13560

actgcgctaa tcagatatat cttcaatagg caccacacag aagtctgaaa gataaagcca    13620

cactgaagat gggttaatag tccaaattca taaaactctg gagaaaccat ccaccctaaa    13680

caggagttaa aacttggaat gaacagcact cctaaattga aagcgttaaa atcaacaaag    13740

aagaccatta taaacatgtt tcaaatcatt agacatcaaa gaaggacttg aaatataaga    13800

ataaaataag atactaggaa gttaaacaga tttggaaggc ggatggggaa aatctaaaac    13860

agataataga aaaaaaaaag aatagcaaat ttgaaaaaaa aaggcgcttc tagaaataga    13920

aacacaacga tacaatgtga aatttcatag ggtggcttaa gcagtatatt tgactcatct    13980

aaagacaaaa ttattttgga agatctgagg aaattactat gcagcagaga taaaaatata    14040

gaatatatta tacaatagga ggttaagaag ctttaaaaat agtatgagaa tatctaactt    14100

atttctgaaa gaaattctag accacaggga gagggagaat aggtaaaaag taatatttga    14160

aaggataatg attgagaatt ttgtaggata gatgaaaccc ccatgttcaa gaagccaaat    14220

acattttaag cagaacagaa aaataaaaca ttcagctgca atgtactgaa agtacaagat    14280

ccaaaagata aagacctgat aatgaataat catgttctag aaggacaatt aaagaaaaga    14340

tcaaaccaga gccaagtctc tggaaataat gtattttctc taaaatggaa ctgctttggt    14400

tgaattagtt ttaaaacaat attaaattgc tgtggttttt taatgcaact ctgtaatgaa    14460

gaatcaagga cactaagttt ggcttatgtt agttatgatt aaatgtcata tggtttctaa    14520

gagatgcagt gaactactaa taaaaacatc aggattaatg atgtatttat tgatcaacta    14580

attttcatag taattttttg cttccatatg tttgtggttc aaatcctata tacccaatga    14640

ttcatacatt ttacatattt tctatgattt tttttcttca ggttcaaagt ttttttcaaa    14700

aagtaagctg ctggacacat tgagaaaagt ggatcatttg tattgctctc cacccatcca    14760

tcttaatgtg ataatgtgga gaagtgctaa aaattaaaag ttaaaacagg gtttggggca    14820

gacagaccct agatctagca tttacaagtt atgtgttttc aggcaaataa catttctgaa    14880

tctgttttct cctataaaat gttaacatta atgtctactt tatttgaagt ttgttgagaa    14940

tattaaaaaa gcaaatgcct tctactgatt tatgccctac aagtcatagc aaattactta    15000

cagtgtttct gaaaatactg ttcaacttct tggcttaaag tttttgttca tacagttccc    15060

tctgtacaga tcaattccct ttgctctgcc tccttaccct tcacctgacc taacatttaa    15120

aggatctgag gtctgaagaa tgactttagt ttgtgtgtca tcaactccag cttcccacac    15180

cccttaagtg cgggttatct gttcctcttc atctacataa gctgccaaaa tttcagttgt    15240

ttcacattta acttcatttc atggaggaag cttttgaatc aaatcaaatg taaatgactt    15300

tccaaagatt ataaaactag ttagtgacag agccaaggca tgaagccagg aatcctcatt    15360

tttatcttaa attacctctg ctgcttatac ttcagttagc agggctagcc ccaccctggt    15420

tacgcccaag ctctgtgggg tgctgaaaca taaaatcttc agaaggatac cctctgtgta    15480

tttctgcgtg aggtgcattt cttccccatg acacagtgat taattcatca ggccttctaa    15540

gacatcctga ctgctgctcc ttgccagctc tgctatcctt tcactggatt atcaggtgct    15600

atcatcttga tctggaccaa tgcgtcttct gaattttctt tttagtgcca acagagatat    15660

ggttttttta aatatagcta aatctccttc tagaactcat cattttcaat ggaaattttt    15720

ctcctttctt gagcctcatt tattgtctgt cactgctgaa aagaattgtc ctcccacctc    15780

taaccatgac caccactacc accatcacca atccccactg aaacacacat ttccttacaa    15840

ctatgcccaa ctctgtgggc cacggagtcc aaggaagaaa aggtgacaaa gtaagaaaga    15900

ctattagtca gatccttttt gtcatgtatt tgtaagaaac agttatactt caagaaaata    15960

agcattttct gcttaagaga ttgcaaatat tcgttgtgtt ctttccactt gtatttttat    16020

ttcatttcaa ttttcctcta aaaatattat tagtgtaatt aatttattaa tttttttctt    16080

tatggcatct ggagtttgcg ttttgctttc atagcacttc tccctttcaa aactcatttc    16140

tttttctttt caaatttaga tatttgatcc atctggaatt tattttggta taaggagaga    16200

tataagattt agcttgcatc tatcctcaga tggttaacca tatgtttcaa cttcatttat    16260

ttgctcatcc ctttccccca gtgattttaa atacctcctc tagtatgtgt ttaatgtcat    16320

gtgaatttga ttccgaactc tctattctat tctactagta tctctgtttc tttgtcagcc    16380

accatcagaa tttaaagatt actaggccct taagaatgat acaacggatt ctagggactc    16440

aggggaaaag ggtgggaggg ggataacata aaagaataca cactgggtac agggcacact    16500

gcttaggtga tggatgcacc aaaatctcag aaatcatcac taaagaaatt tatccgtata    16560

accaaacacc acctgttccc ccaaatccta ctgaaataga aaaataataa taataaaaat    16620

taaagaatta ctgtgccttt atgtgcatta gtatctgtgt tgctaatcct tctcttgtag    16680

ctcttcaatt tcaaagattt tacggctctt cccagatgtt tgttttgtca tgtaaacctt    16740

agaatcaact tgcctaattc caaagaaaat gaacctattg gtatttcatt ggaattctct    16800

atttgtggat taatttagaa aaaaatgata tctttataaa tattgtctac ttaagaatca    16860

aatacatctt ttgcttaatt caaggatgtg tatgtgtacc tgtgtgtgga cacatatgta    16920

ccttaaaggc attttaaact tttcctcatt aaatcttgtt catttcctgt ttagtttatt    16980

cctagacaat ttttgttgca gctgtgtttg ctatgattaa aaatgagact ttttattcca    17040

ttacatttta aacatgctgt tcctttttta tgggaaagct cttgatgtct gcatattaac    17100

tccataacaa tcaagaggct gaacttttca attgcgtcaa attaagttta acttgattaa    17160

ttgagcttct gtttgtgtaa tcatggcatc tgcaactcat aacaattttt ttgctctttt    17220

gtttttatat cttttttgtt tccttctttc tctgattaaa ttggtagtat ttaggacaag    17280

gtcatgatat aaatggctgt taagcattct taaacttatc catcccttta atgggactaa    17340

atgttttgct attaggcatg atgctggctt gggctgaagg taatattttc aaaataagat    17400

tacaactcat gtgaaaggaa aaatacttct ctacctctaa gtagggtgca cctttgcctc    17460

tactctactc aggggactta ctttgtttgt aagaataaat caggcatgtt cgacacaact    17520

cttttttcct cccttttagg atcaagatac tgggagaatg aagtcttctc tttgccaaaa    17580

ctctgacctg ggcatctctt ccaactttcc tactcgatgt ggaccagaac attcttgtcc    17640

agcattacta aacccttgct ggatatgatt gtctagtctg atgttaaatt cacaagtcta    17700

tttggctttc tcaccaagcc atatcttctg tggtgttcct taaaagcaat aaacatacat    17760

tggtgtagat atgctcttcc tttgcttttt tcttaatttt tcaggataat agagtaggtg    17820

tccattcata cttttagcag gaattgtgaa atttttaatg aaagttggac cttatcaaat    17880

acttttgcaa catcgactag agataattta attatctctc tttttttgtt ttgttactct    17940

tttcacaaat agacaccaat gtggggctta ataaatcatt tttgcattaa attataatta    18000

aatgtttaaa tgtttatgag taaatggagt tatcataaaa agtaatagta gtgtttactc    18060

ttcttactat atattttcag atacgattgt taaaagtaag tcctttttaa atcatattaa    18120

ttaaagctac cagtgaggaa catcagtggg ggtgtggctc ctattcaggt tttagctgtt    18180

aaaaatattt tccattacca ccaaatatag aatcagaaaa tgtcttgaga aagcaatcaa    18240

catatcgtag atcactgtat agaaaacata agttatagtt tccagggtgt ataagaacat    18300

catggagcat gaagatgtta ccaactaaat gtatatgaat atacaatttt aaatatttat    18360

atttgatgaa agagtagatt cagattaatg ccctaatgtt tttatgtact aaacataacc    18420

ttacggattt attttccaaa gactaacata aaaattaaat atgcatttaa aatgattttt    18480

aatgcagcat cataaggcaa tgacctgaaa gtgggagcaa gaagacatag ctttgaagag    18540

ttatacaaat gtgacaattc tgaaaataag ttgaggtgtt taaaagtata gatgctagag    18600

atggataaat ctatatatga atgtcagctt tagaacatat tagctgtgtg actttggaaa    18660

tattacttaa cctctgtgag cctcagtttc cttgtctgca aaaggaaaag aaaaatagaa    18720

agcaccatac caccatcaag tttgctgtaa gagatacatg taaagtgtta acatagatac    18780

ctggaatata acaaattttc agtaaatgac aataattatt ttttcaataa atgatagtaa    18840

ttaatgtaat tattgtttac aaggttatat tattgttaat tatcattatt ttactccttt    18900

cagttaagat caacatatca cttatttttt ctatacatct aaggtacaag gcttcctaaa    18960

caagtttcaa aactgtattt tctataataa ttattgccct taccacctaa atattaacac    19020

cttatagttg tttggaaagt ttgtgctgga aagtagagtt ttcctttccc aggagatcca    19080

cattaaacct gataactcaa ttgcaactca gttttttgaa agattttctc atagtaatct    19140

ttttagcatt ttaaaatttc tctgcgattc tctttcctta aaatttttct cagtagaaat    19200

ttattgaaat aaaacaaaag gatgctgact ctcaccattc atccttctcc aaaatatata    19260

ctctaaatta ggactgctag aaaacaggct tcttaatata taatctatat atgagtggat    19320

catatgtgtc atatctaaga gtaatgaacc tgtatttaaa atactttttc aatgtggaaa    19380

tgctttaaag tagttcactt gccctcccag ctttattgca aaataattac caaaatttgt    19440

atatatttga ggtgtaaaac atgatgattt tatatacatt accacaatta agttaatcaa    19500

cacattcatt gccacccagt taccttttgt gtgtgtgttt gcgtgtgtga tttcaagtaa    19560

gcaatacagt actattaact atagtcactg ttccatacat tttattccca gaacctattc    19620

atcttattac tcaaattttg catcctttga ccaacatctc cccattcccc acccttcacc    19680

cctttctcct ggcagccatt aatccactct ttccttccat aagtttgact tttagattcc    19740

acataaaaga gagattacac cgtatttgtc tttctatgtc tgacatttca ctcagcataa    19800

tgtcctccag gttcatttat gctgttgcaa gtggcaggat ttccttttta tatggctgaa    19860

taaaatacta gtttgtgtgt gtgtgtgtgt gtgtgtgcgg gcatgtgcat ttatgagatc    19920

tacatatgtt atatataaaa tatttttaga attattcgtc tgtcaaaaga catttaagtt    19980

gtttctacat tttggctatt gtgactaatg ctacaataaa catgggagtg cagatatctc    20040

ttcaagatac tgatttcatt tcctttggat atgtgtcctg aggtagaatt gttagatcat    20100

atggcagctc tatttttatt tttttataaa cctctatgct gattttcata atagctatac    20160

caatttacat tcccactaac agtgtacaag gtttcttttt gtttcacatc ctcaacactt    20220

gttacctaca ctatatgcaa agacctgaga tgtttcttat gcacagtaaa gtttgagaat    20280

ttccatactt catttattta tctaagttcc tgatattctt caaatcttga tataataatt    20340

ttttacttgt tcagctcttt gacttttaaa atatttccag aaaatatttt atctaccatt    20400

tttagttgta ttctatggga gtgtgactcc aaataaccta gtttgctatt attggaaacc    20460

agaagtctca atcccatctc cacttgagaa aattatactc aagctttcaa agctctgcca    20520

tgattctgct cttgattgct ttacacatat gtgatttctt ctttgttcaa gacatcgtat    20580

aacctctctt tctcttattg tcttagtctg ttataataaa gacactgcta ataaagacat    20640

actcaagact agataattta taaaggaaag aagtttagtt gactaacagt tccacatggc    20700

tggaaaggcc tcacaaacat ggcagaaggt aaatgaggag caaagttatg tcttcatggt    20760

ggcaggcaag agagggtgtg caggggaact tctctttata aaaccatcag atcctttgag    20820

acttactatc acagcaacag cacagaaaag acctgcccct ttgattcaat tatctaccac    20880

caggtctctc ccataacacg tgggaattac gggagctaca attcaagata agatttgggt    20940

aggaacacag ccaaaccata tcacttattt ttcagtcatg agtaaactcg gtggtttcct    21000

atttatttat ttatttattt agagacaaag tctcgttatg ttgcccaggc tggagtgcag    21060

tgggactatc ctggctcact gcaacctctg cctcctgggt acaagagatt ctcctgcctc    21120

agcctcccaa gtaactggga ccacaggcac gcaccacctt gtctggctaa tgtttgtatt    21180

ttcagtagaa atggggtttc accatgttgg ccagcttgtc tcaaactcca gacctcaggt    21240

gatctgccca ctttggcctc ccaaagtgtt aggactacag tgttaggtgt gagccatggc    21300

acctggcctg gttcccttta tatatcatgt tagacactta atgccaggca gtatattttg    21360

ttccctgaag caactagttt gtgctttgca caaaacagtc actcaagatt tattgcatta    21420

aaaaaaattt caaaaagtat tggttgagaa attattaacc aaaatatcac ttcagctatt    21480

tcccacattt ctcaattgca acaagcaata gtcttgagca ataaaaaact tcccaggact    21540

cttcctctca cattccactt gagtttacat aaaataatgt gaataggccc agtttgtttt    21600

tcttctaaaa tggtgcagct gctgaaacat tcaactgaca cttgtttgaa ttgtgataat    21660

aaatgtgttt catcagtcca attcacagaa ctccctaagt ggcctcagtt cacaggcaaa    21720

gaaggaatgt gactcccaag gagcataatt ctatacagat gtggtcaagt gagacacaaa    21780

atcccaaact gcaggcaaat acatgaaaag atgtgaggaa ggaaatcatt tgcatagaac    21840

ataaggtatg tgttgcctta attgcttgta tagttgaggt aaaaattgtt ggccagaaaa    21900

tagtctggaa tcattttaga agttgtcata acccaggtaa caaacgctaa tttcatcatt    21960

tgctacttat ctagcctaag atactatgga tcataataca aatcattacc ttacatacca    22020

ttcagaaagg gaaaaatcag cccaagtaat ctgtgttctc catcagtgat aagccatgcc    22080

acaattatag agattttaaa atgtgataaa atgtgccttt tagactcact gaaatacagc    22140

atgtgtctta tcatcttcaa cactctattt tcaggcagtt gtgcattgag ttgtagattg    22200

tactgctgag gaaaagcaag tcttttacct gtaatcttgc atctatcacc catgatatat    22260

ctacctacag agaaaaagag gtgtattgta aagttgactc atctagtctc tctgcttctg    22320

agggaaacat tgacttattt agatgggtga gtttgaaaca atcaactttg cataacatct    22380

cctgcttacc tttttcacag aaccactcac cctcctgtaa agtaaatgat ctgttctgct    22440

ctctgccaag aataaaagta gcttatcgca tagggcatac ctaagatttt ccaacccagc    22500

ttgtgactac atagataggt ctgcctaatt ctgggggtca gtgttaggaa gtacacctgt    22560

ccacagaaac aaaccactgg ctctagtacc agcttcatta ttagtaagca ggatattttt    22620

atatcttatc taagttactt tctttttcat ctcaattgaa tcaaaagtca taactcaaga    22680

agggataaac gatgctacct gtaggcttcc tagaaaaaca actagcatac atgcacgccc    22740

ttggctctga tgagcaggaa gccctctata ctagaacgga aaaactacaa taagatggtc    22800

cattaaaggt ggcattgtga agttcaatcc atcatgtaat catccctttc tcatcctgcc    22860

tgacacagtc ataatcacaa ccccagtctg cttctgagtg tgttgagtgt gttatttctt    22920

atctgcccag ggggacctat tctttcttct cattctcctt tggcttctct tagcctcctc    22980

ccaacaaaaa tgcagtgcaa agctttattt ataacctgtg ataggtttgg ctgcctttgt    23040

tctgccatca accgtcagag aagcaaccca ggcactaatt caaaccaaag agcaggcagc    23100

catattctat tggagcggat gtggcatggt gtaaagatct cataaggacc atgtgttgac    23160

tccctgaaag ccatcacatt agaataaata attataccaa tgcaaccaca atctactttg    23220

cttgtccaca ttctcaaaga ccaacaaact gagaccaaaa gcagctatga cttccagaag    23280

tgaagtttga agatagaacg acttcggccc agctccacgt ttatcctatt tctttgtatg    23340

cattttatat tgaaaaaaat acggtacatt ttcttcataa aaattctgct gggatgctta    23400

tttttatttt cttcacctag gaaaatcatt cccatacact gcactgactt ttagattatg    23460

taatataact tgtaattatt ttattttatt ttttttttgc agcttgcctc acatcctctc    23520

agtcctcctg ctactcagca attcctgcag caaacaaact gctctgtgtg agtttaacca    23580

aacagcatgt ggtgttagct acattccatg ccctcgtttc atgtcctgga gcttttctaa    23640

catgggagca cccaggagtg acaggcagtt gacctccttt gtgccactga tggatattat    23700

gggatgggag ctgtcagtta aattctcccc acttctaccc ctaggacaca ttattctgag    23760

gcacaactac gataagcatt atcattctct tcacctggaa gaagttgtag aggttccatc    23820

tcagaagacc agaaacagca tgataaagca tggacttcct caagaagaag aaatcacatt    23880

tagagctgtt gaatttagaa caaggcagaa ggagatggtc aaactagttt gttctacacc    23940

ttgttccaac atcttttcaa gagaaaaatc actggcccta atggaaggat gtttatgtaa    24000

ctaacataaa gagatgtcat aatcaccaat tagaaagaga gaatgcagat gagaatcaga    24060

gcaatgctca gtgctcactg aatctatatt atagcaggct aatgttagtc taaggctgac    24120

tctatgtgca atgacttaaa aaatattatt ttagagttct tcagaagact taacagtgct    24180

tttggcattt attccattac aatgtgctag acagacatga taatttgtag tgatacaatt    24240

gttcaataca ggtaacttat tttaccaagc ttttcttctt tttttcaaat caagatggtt    24300

aaactgttat agtaggtagc tagtcagaca tgaacagggc aagagaaggc tcccctcaca    24360

catacacagc gggaacacca ggcgaccagc agatgatggt caggcagttg ttaactgagt    24420

ctctaaaaca ataattggtc acagccagta ccaggggagg gcagtctccc catagataga    24480

aaacacctga aactagtgat cagcagcttc ccaataagat ctcagaagtt gggtgagcgg    24540

gctcaagcat gcacattaaa atggcagaat ttaatcagca aatgaccttc caggaacatt    24600

tgactggtaa aagaagaacg cctcaagtga gcatgtgtgc aactccagta aacacactgt    24660

acatgctcaa ctcccaagtg ctagcaggcc actgtgcatg cagacagccc atcccaaggg    24720

aagaatcggg agaagtaagg caagaccctg gaagtacgcc aatgtataaa accgctagtc    24780

agaaggtcaa acctcacact gaatctctca agtcacccac ttggccctct tccaagtgta    24840

ctttactttc tttcactctt gtcctaaagc tttcaaataa gctttcaccc ctgctcaaat    24900

acttgcctca gtctctcctt ctgccttatg cccctccgtc aaattatttc ttctgaggag    24960

gcaagaattg agatggctgc agaatcatac aggtaaggat ttgctgccgg agcaaaacta    25020

ccagacaatg tcaagcacag tgtgttccca gcgcaataac agattacaca tttatgaggt    25080

tttatgagtg acacatttcc agagcaaagc tggagaagga accacataga tatagatcaa    25140

taatagaata attgtgacca ttgcttgttc tttctgaggc tggacaatta aaaagaagtc    25200

aggctgttat gaacctccag aggtgactta tttctcctaa ggtcacaagt gaggaagacc    25260

actgccttaa gtcattgccc aggctcaaac actgagagga gatagagttg aaaatggatc    25320

cagatcagtc ccccaaccag gcaaacagcc tcactcagga aacttgtttg gtggcctcaa    25380

aggtcacttt tttttcatga tacaccttga cacacctagg aaaaaaatat ttgaaaggtt    25440

tgaagggtga accgatatca tccagaaaga agagaagaaa acagggcttg gtcacataca    25500

atgtgaagag attattcgag agtgacttct cttgccaatg actagcagag aaacttcaaa    25560

aaagaggcaa caacttccct tggttatgtg ttttaccaaa tgaggtctac ctttaccact    25620

gcagcagaaa tgctgccttt cttaactcgt tcacttatgt atctcaaaca gcatgcgctt    25680

acctaaaaaa gcactgtaga aaaaggtaat acgaatcacg gacattaata aaatctgtgg    25740

aatcttcctt tagttatcat taaattcatc caaatccaga tcattaccat aacggacatt    25800

gtaaaattct caggaaaaaa agccattttt actgaacata tcttagcaaa gtctattacg    25860

gttaaactat tgtaatgtgc tttctcagta actcaatttt atttaattat tgctattttt    25920

taggaataga gcaaaagtat ttgctctgag cgtcctacat gtggtttaac attgtggaat    25980

agttcatatt ttcagagtga attggaagaa tttgttctac ttagtctaaa acccaacatt    26040

ctgaaataat tttgattgtg tttaagtcag atccaggact taccaatatt ttggaaactt    26100

attttttgta ctgcacaatg accttttaag aggtcctttg taatatgctg acaccatggt    26160

gaacacaaag tttataggaa gaattcttta ttttattttt tttctttgag acagggtctg    26220

gctctgtcac cctggctata agtgcagtga cacaatcaca gctcactgca gccttggcct    26280

caagtgattc tcccacctca gcctccctag tagctagtac tacaggccca tgacactttg    26340

cccggctaat ttttgtattt tttatagaga cagggtttaa tcatattgcc caggctggtc    26400

tcgaactcct gggctcaagc ctcctgcctt ggcctcctaa agtgttggga ttacaggtat    26460

gggccaccac aactggccag ttttaatttc taatacagta aatatcaatg gttataatcc    26520

atatttctaa caaaaaaaaa gctctttttg ggtcctgaat aatttttaag agtttcaaat    26580

tatcttgaga ccaaaaagtt tgagaatcac tttctagagc aatgctttcc aaaagaattt    26640

atcataatgt tgaaaatgcc ctataaatct gcactgtctg atacaaaagc cactagatac    26700

atgtagctgt tgagcagtgg ctagtgcgac taaagatctg aggcttttac ttttattaaa    26760

tttaaattta aatagcaact gtgggtagta gctagcatat tgggcagtgt ggtcatagac    26820

cttcagtgtg ctggctcctg atataatatt ttttccaata ttccacgcaa gttaatagtt    26880

agctcatttt ttcttctgct aaccattaag ctcttggctt ggtttgtatg gggtgtaagg    26940

gaggtgttta accacaaaat acgtaataag agaattatca tgcatagttt tgaaatatga    27000

atgaattcca gattaaatcc ttgactcaag atgaaaaaaa ccattgtagt tgccccactg    27060

ggaattaaac agagttcaag agaatgtttc ttcatgcctc atcttgaatt aactacacag    27120

actataggca actgttttaa aattataaac aatgttttag gctttgtttc tgttgtagac    27180

aaaaatgtaa ttgttccagt tacaaaaaaa aaaaaaaaaa aaaaaaactt gattgagttt    27240

ccaaacatgg tacgggcttg acttggtatt aacatcattc attagaatct gaatcttagt    27300

tggaattcct ggatttcatt ttgtggaact atctggctat cgtgcagttt ttacccttgc    27360

taaccaagca cagagcacag aggaaactct caacttgaaa atataaacct tgaattgtgt    27420

gatcctgtgt gagttacaga acctctctaa acctattttt tctcataaaa taggataata    27480

atattattag ggacttctct acatattgag aggattaaat gagataatgc acatgaaaca    27540

tttagtataa ctcctgaaac attgtatata tttagggggt ggtggttatt accctaataa    27600

ctgctattaa ttacattatt tataattaat ataatgtcta cactacatat actatattat    27660

ttataattaa tattatatca attatatttc taatcagtag gcataataat atatcaatca    27720

tgattgttat gattaatgta attaataata taataataca atttataata aataattagt    27780

aatattatta actgtgctta ctggactttt ttttatgagt cagctatgtg ccaggcaatg    27840

tgttagtgct agtggataag tggcctctgt ccatgtgtgc atggagcttc caatctagag    27900

agggagagag acactcccta gagagtattg tgaggattaa actttaaaag agaaaagagc    27960

tgggtcctaa gataggatgt atcaaggaaa attgttttga tctagagggt aggaggatgg    28020

aatgtttaag ctgagtcctg aaatacagtt ctagcaagat ttactactgg tagaaatgtt    28080

tcagggtata ttggttggga tgatggttaa caaatagact ctaaagttca gtgactaaac    28140

aagacataag tttatttctc tttcacttaa cagtccagag taggtagtca ggttttgctc    28200

tgtaaagtca tccagagtcc caggctacaa tggtggttct gccattcttc actgcggctt    28260

ctacagtagc tccatcgcca ctatgtccaa ccagcaggaa ggaaaggaag atggacaact    28320

aggaagaact tatttaaaca gaagacctga aagttacact tacccaggaa ggtcagctgg    28380

gtgtttagac atgccattgt tgaactagcc tgacttggtg ttgtcgtcat tcactaggat    28440

ctgaattttg tattgctgca ctcttgtctg aaacatgtag gtaatacaga aattatgttc    28500

atatatataa attttatata ccctaaaagt tagtttagtt caataaacac ttagaacttg    28560

tacttttttc ccccttagag ataaaaacat ggttaatact ttcattcact tacttgtatt    28620

ctcattcatt cagcaatgtt catcgaatat caacaacctg cactaaattt caggcacttt    28680

gaggatgttc atgaaacaca gcccttgatc tcaagagatt cagagtctat tgtggatcgg    28740

aggggagcaa acatcacagt ttagtgcaaa atagagagaa agatgtgata ttatctgcat    28800

ataaataagt gctgaagaag gtggggactg ttctctgcca agagaatggg gaaaggttgt    28860

gggaacagag ccatctgaga gaacttgaat attgatttta taaacaaaga agaaccttcc    28920

ggtctgatat ggtttggctg tgtctccacc caaatctcat cttgaatcgt agctcccata    28980

ttcctgtgta tcatgggagg gacccaatga gaggtaattg aatcatgggg gtggatcttt    29040

cctgtgctat tctcatgata gtgaataagt ctcatgagat ctgatggttt tataaatggg    29100

agttcccttg cacacactct cttgcctgct gctatgtaag atgtgcctca ctctttgcct    29160

tctgccatga ttgtgaggcc tccacagtca tgtggcactg taggttcatt aaacctcttt    29220

cctttataaa ttatccagtc tcaggtatgt ctttattagc agcatgagaa tgaactaata    29280

cacagtctat gagaaaagtc ataaatagct cagtgtgatt ggctagttta ggggtggcaa    29340

atagtccaga gtgggtgaag tagctaatca atagataaat gaaaatagaa tgttaaaaga    29400

gagacaaatt gtgaagaacc tcaaatgtca agcaacatat atttgaattt gtttaataaa    29460

taatgggaaa ctagtgcaga tccttaagag gggatagatg tgactggatc tgagtttcag    29520

aaagagtgcc ctggaggcag catacacagt taagtggcag ctgaacttat aagcatagat    29580

gcagggtttc cagagtaaat cctgcccctg atgcctgtgt gatgttgagc aattggttta    29640

cccaccctgt gccttaactt tctcatcatt aaataggaat gataatgata gctatttcat    29700

agaactgttg tgagcattaa attgagtaat tcatgtcaag agtttaaaat aatgtttgac    29760

atttaatagg gatacataaa cgtttacaca cacacacaca cacacacaca cacacacata    29820

tatatatata tatatacctt ggagagaaat ggaaacaaat taagaaaaca gaaacatcta    29880

gtttgagcta ggctaaaaag ggcagtgtag atacaggaac aagggacctg gaaacagatt    29940

atctcgtgcc caatcgcaga taaattgttt cttaattgtt ctaacccttt tttttctctg    30000

taaattagaa ataataacag tgcctatttt atagaattgt gaggaattaa attacacaat    30060

acatgcaaag tgctcagcaa agagcctagc atctactgat cactcacaag atgagaattt    30120

tcattatcaa aaaggattta ttctaaaagc ttgaaattct ataatttttt acctctgaat    30180

tagttttgtc ctttatcgca acattgatgt agtacaaaaa acacagacat tataaccagg    30240

taaaactgat ataaattttt attctgtcac ttcaaagcag tgtaaatttg ggcatatttt    30300

ttctaaaatt taggagcacc tgtttcctct tgagacaatt ataatgcttc ccacagtaaa    30360

atgttgctgt gaagattacc tgaaataatt tgcataaaga acctagactg gaacacagta    30420

aacacgtaat agaagttgaa tgcccccctc ctcacacatg cctttttttt tctctaactc    30480

tctctcacat ctgctctgag agattaaaaa gtcacatgca acctcaacct gggcatatct    30540

agtctaacca agactgatga gaatcccatt ttagttgcaa gcagaagatt gaaaacagag    30600

aagcactgtt gtgaatcatg agttgtgggt tcaggccgag aaggacaaaa ccaaactaac    30660

ccaatccctt cacttgccaa acctcttgct gtttgacccc cgactaacag ctaaccaaaa    30720

ttagccacag accgctgatg agcgtgtgag ccattgtgca acttttccaa ctggatagaa    30780

catgaaaaat taaggagaga aggaccatcc aacagagagg cagtgagggc tgaaaataca    30840

agggatgatt atagtaggct tggcagggga caggatatgc attaatgtgg agagagggat    30900

tttctttttt cacatcaaaa cacacagaat ttgaccacct aagtgaacaa gctttcttca    30960

tatctgggag tcttgatgac atagttttta agaaaactgg tttaggaata gtgattgctg    31020

agttcaaacc ctggctccac catttgtgag ctgttatagc cttgagtaag tcatttaaaa    31080

gttccagctg ggcgcagtgg ctcatgcctg taatcccagc actttgggag gccgaggcgg    31140

gtggatcacc tgtggtcaga atttcaagac cagcctggtc aacatggtga aaccccatct    31200

ctactaaaaa atacaaaatt tagccgtgca tgatggaggg tgcctgtact cccagctact    31260

caggaggctg agacaggata atcgtttgaa cctgggaatc ggaggttgca gtgagctgag    31320

attgtgccac tgcactctag cccctgggcg acagagctag actctctcaa aaaaaaagaa    31380

aaaattctga gccacctttt ccttgatagt tcccaaatca ttacactaat gcaatgatta    31440

agtattatca taacctttac aaagcagatg aaatagaatc ttgggacata ttaaatattt    31500

aaagatatta gctattacaa ttgtgattta agtttttagc tggtcagcac actttaagga    31560

gagttgaggc aattgtctat tacagatggt acagatgaca aataagatga gtcaggcaag    31620

taagatgagt ctgcttgact gatctcattt cttagattta tttagtgtag aattaaccta    31680

aaattacttt ctttaaaata atttttctac tagatttcat tgtcatccca agtttttaaa    31740

attctatttt cctgaacttc tgatacatga cacttttccg tttctggaga aacttatcct    31800

attcacaact tctatcaagt gacttgcttc ttaagtatct tcaggcttgg ctattgctca    31860

tagatctttt atctagccct taccactcct caatgtggtt tgaatcttac tgccttccct    31920

tctgactcta atctaaataa taacccttga aaagaaaagc tcagtttcac cttctagcta    31980

tacaagagca ttctctttac ctaagttaga ggaagtgctc tcttgttcac tatttagcat    32040

tttgtggcta gagacaaact gggttctctg agcctgcaga ggtaaaataa caactctcac    32100

cttcacccat gttagaatta atgaaagaaa caaatctcat atcgacaaag attctttgct    32160

tgactaaact ttagtcagct cctctaccat ctcctaagcc catctgtgaa tagccttgta    32220

aaatctagta ttagcaaaga agcctgctaa atcaggttag caagaactac cccatccttt    32280

tccagacccc aggtagtgtc taatcactct ggtctgtctt cagcaacaat tctatcaggt    32340

cagtctaggc cagaatcccc ctggtgcctg acgtttcctc tcagtaattt tccatccact    32400

gacccccacc ttgcaccttg gctataaatt ctcacttgct cctgctgtat ttgaagttga    32460

gctcaatctc tttcccctct gaaaaatcac actgccatgg tctctatggt gaccaaacct    32520

attgtgatgg tctcgaataa tgtttgccat acggtgcttt aacaggtatc actaaataca    32580

tttttttatt taacaatgtg catgaaacaa ccagagaata gagtccaggt aattatgaaa    32640

ataaggaaga taatatggta tacatgatat atggatccac cagaggcatg agactagaca    32700

tattgctttc tgggaaacag cagttactac agctgggaaa gggaggggag gtagtaaaga    32760

aatattt                                                              32767


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify CXCL2 subsequence, assay 103070

<400>  37
cccatggtta agaaaatcat cg                                                22


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify CXCL2 subsequence, assay 103070

<400>  38
cttcaggaac agccaccaat                                                   20


<210>  39
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL2 transcript-specific amplicon of assay 103070

<400>  39
cccatggtta agaaaatcat cgaaaagatg ctgaaaaatg gcaaatccaa ctgaccagaa       60

ggaaggagga agcttattgg tggctgttcc tgaag                                  95


<210>  40
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the CXCL2 
       transcript-specific amplicon of assay 103070

<400>  40
cttcctcc                                                                 8


<210>  41
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 212657_s_at; covers a part of the corresponding 
       human genome target sequence at the IL1RN  locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 
       2:113864791-113891593. Genomic location of design 
       probeset-sequence as specified in this entry is 
       2:113891109-113891570.

<400>  41
ggtactatgt tagccccata attttttttt tccttttaaa acacttccat aatctggact       60

cctctgtcca ggcactgctg cccagcctcc aagctccatc tccactccag attttttaca      120

gctgcctgca gtactttacc tcctatcaga agtttctcag ctcccaaggc tctgagcaaa      180

tgtggctcct gggggttctt tcttcctctg ctgaaggaat aaattgctcc ttgacattgt      240

agagcttctg gcacttggag acttgtatga aagatggctg tgcctctgcc tgtctccccc      300

accgggctgg gagctctgca gagcaggaaa catgactcgt atatgtctca ggtccctgca      360

gggccaagca cctagcctcg ctcttggcag gtactcagcg aatgaatgct gtatatgttg      420

ggtgcaaagt tccctacttc ctgtgacttc agctctgttt ta                         462


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify IL1RN  subsequence, assay 103133

<400>  42
tgcctgtcct gtgtcaagtc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify IL1RN  subsequence, assay 
       103133

<400>  43
tctcgctcag gtcagtgatg                                                   20


<210>  44
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL1RN  transcript-specific amplicon of assay 103133

<400>  44
tgcctgtcct gtgtcaagtc tggtgatgag accagactcc agctggaggc agttaacatc       60

actgacctga gcgaga                                                       76


<210>  45
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the IL1RN  
       transcript-specific amplicon of assay 103133

<400>  45
ctggtctc                                                                 8


<210>  46
<211>  551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 218469_at; covers a part of the corresponding human
       genome target sequence at the GREM1 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 15:33010175-33026870.
       Genomic location of design probeset-sequence as specified in this
       entry is 15:33026285-33026835.

<400>  46
gaagctgaca caccgtatgt tgttagagtc ttttatctgg tcaggggaaa caaaatcttg       60

acccagctga acatgtcttc ctgagtcagt gcctgaatct ttatttttta aattgaatgt      120

tccttaaagg ttaacatttc taaagcaata ttaagaaaga ctttaaatgt tattttggaa      180

gacttacgat gcatgtatac aaacgaatag cagataatga tgactagttc acacataaag      240

tccttttaag gagaaaatct aaaatgaaaa gtggataaac agaacattta taagtgatca      300

gttaatgcct aagagtgaaa gtagttctat tgacattcct caagatattt aatatcaact      360

gcattatgta ttatgtctgc ttaaatcatt taaaaacggc aaagaattat atagactatg      420

aggtaccttg ctgtgtagga ggatgaaagg ggagttgata gtctcataaa actaatttgg      480

cttcaagttt catgaatctg taactagaat ttaattttca ccccaataat gttctatata      540

gcctttgcta a                                                           551


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify GREM1 subsequence, assay 103109

<400>  47
ccgccgcact gacagtat                                                     18


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify GREM1 subsequence, assay 103109

<400>  48
gcaccttggg accctttc                                                     18


<210>  49
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GREM1 transcript-specific amplicon of assay 103109

<400>  49
ccgccgcact gacagtatga gccgcacagc ctacacggtg ggagccctgc ttctcctctt       60

ggggaccctg ctgccggctg ctgaagggaa aaagaaaggg tcccaaggtg c               111


<210>  50
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the GREM1 
       transcript-specific amplicon of assay 103109

<400>  50
cagcagcc                                                                 8


<210>  51
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Affymetrix ID 225664_at; covers a part of the corresponding human
       genome target sequence at the COL12A1 locus


<220>
<221>  misc_feature
<223>  Genomic location (strand) of marker gene is 6:75794042-75915767. 
       Genomic location of design probeset-sequence as specified in this
       entry is 6:75794232-75794582.

<400>  51
tacaacacaa acatgcaatt ccctctctgc agaataatct gcaatttggt ataaatgtta       60

gtgtgtctaa aacaaggagg tttaaggcaa tatggaactg tatcccgttg atgcactaac      120

ttcatctaca tggcttaagg tttgtggttg ttaaagagat gtatacgagc attctatgcc      180

ccggcgtata acagagatag aagaggaaga taagtaattg caatggagtt gacgtttccc      240

tcctttttgg ttttaggagg ggaattattt gaatcgtggt gtaattgaat tgaaaataag      300

tatagcaaaa gataaactgc ccgctcgaaa tacacagcag ctctgggttc c               351


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (left) primer to amplify COL12A1 subsequence, assay 
       103045

<400>  52
tggcttcagc attcccttag                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse (right) primer to amplify COL12A1 subsequence, assay 
       103045

<400>  53
aggtttcgag gtgctccttt                                                   20


<210>  54
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL12A1 transcript-specific amplicon of assay 103045

<400>  54
tggcttcagc attcccttag ctggagagga gaccaccgaa gaagtaaaag gagcacctcg       60

aaacct                                                                  66


<210>  55
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hydrolysis probe (UPL) for RT-PCR detection of the COL12A1 
       transcript-specific amplicon of assay 103045

<400>  55
tcctctcc                                                                 8


