                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  TRANSGENIC IMMUNODEFFICIENT MOUSE EXPRESSING HUMAN SIRPalpha.

<130>  362837D30774

<150>  EP 12305351.4
<151>  2012-03-26

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  504
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens signal-regulatory protein alpha (SIRPA)

<400>  1

Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 
            20                  25                  30          


Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 
        35                  40                  45              


Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 
    50                  55                  60                  


Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 
65                  70                  75                  80  


Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 
                85                  90                  95      


Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 
            100                 105                 110         


Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 
        115                 120                 125             


Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 
    130                 135                 140                 


Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 
145                 150                 155                 160 


Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 
                165                 170                 175     


Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 
            180                 185                 190         


Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 
        195                 200                 205             


Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 
    210                 215                 220                 


Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 
225                 230                 235                 240 


Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 
                245                 250                 255     


Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 
            260                 265                 270         


Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 
        275                 280                 285             


Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 
    290                 295                 300                 


Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 
305                 310                 315                 320 


Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 
                325                 330                 335     


Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 
            340                 345                 350         


Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 
        355                 360                 365             


Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 
    370                 375                 380                 


Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 
385                 390                 395                 400 


Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 
                405                 410                 415     


Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 
            420                 425                 430         


Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 
        435                 440                 445             


Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 
    450                 455                 460                 


Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 
465                 470                 475                 480 


Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 
                485                 490                 495     


Ala Ser Val Gln Val Pro Arg Lys 
            500                 


<210>  2
<211>  4201
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Homo sapiens signal-regulatory protein alpha (SIRPA)

<400>  2
tccggcccgc acccaccccc aagaggggcc ttcagctttg gggctcagag gcacgacctc       60

ctggggaggg ttaaaaggca gacgcccccc cgccccccgc gcccccgcgc cccgactcct      120

tcgccgcctc cagcctctcg ccagtgggaa gcggggagca gccgcgcggc cggagtccgg      180

aggcgagggg aggtcggccg caacttcccc ggtccacctt aagaggacga tgtagccagc      240

tcgcagcgct gaccttagaa aaacaagttt gcgcaaagtg gagcggggac ccggcctctg      300

ggcagccccg gcggcgcttc cagtgccttc cagccctcgc gggcggcgca gccgcggccc      360

atggagcccg ccggcccggc ccccggccgc ctcgggccgc tgctctgcct gctgctcgcc      420

gcgtcctgcg cctggtcagg agtggcgggt gaggaggagc tgcaggtgat tcagcctgac      480

aagtccgtgt tggttgcagc tggagagaca gccactctgc gctgcactgc gacctctctg      540

atccctgtgg ggcccatcca gtggttcaga ggagctggac caggccggga attaatctac      600

aatcaaaaag aaggccactt cccccgggta acaactgttt cagacctcac aaagagaaac      660

aacatggact tttccatccg catcggtaac atcaccccag cagatgccgg cacctactac      720

tgtgtgaagt tccggaaagg gagccccgat gacgtggagt ttaagtctgg agcaggcact      780

gagctgtctg tgcgcgccaa accctctgcc cccgtggtat cgggccctgc ggcgagggcc      840

acacctcagc acacagtgag cttcacctgc gagtcccacg gcttctcacc cagagacatc      900

accctgaaat ggttcaaaaa tgggaatgag ctctcagact tccagaccaa cgtggacccc      960

gtaggagaga gcgtgtccta cagcatccac agcacagcca aggtggtgct gacccgcgag     1020

gacgttcact ctcaagtcat ctgcgaggtg gcccacgtca ccttgcaggg ggaccctctt     1080

cgtgggactg ccaacttgtc tgagaccatc cgagttccac ccaccttgga ggttactcaa     1140

cagcccgtga gggcagagaa ccaggtgaat gtcacctgcc aggtgaggaa gttctacccc     1200

cagagactac agctgacctg gttggagaat ggaaacgtgt cccggacaga aacggcctca     1260

accgttacag agaacaagga tggtacctac aactggatga gctggctcct ggtgaatgta     1320

tctgcccaca gggatgatgt gaagctcacc tgccaggtgg agcatgacgg gcagccagcg     1380

gtcagcaaaa gccatgacct gaaggtctca gcccacccga aggagcaggg ctcaaatacc     1440

gccgctgaga acactggatc taatgaacgg aacatctata ttgtggtggg tgtggtgtgc     1500

accttgctgg tggccctact gatggcggcc ctctacctcg tccgaatcag acagaagaaa     1560

gcccagggct ccacttcttc tacaaggttg catgagcccg agaagaatgc cagagaaata     1620

acacaggaca caaatgatat cacatatgca gacctgaacc tgcccaaggg gaagaagcct     1680

gctccccagg ctgcggagcc caacaaccac acggagtatg ccagcattca gaccagcccg     1740

cagcccgcgt cggaggacac cctcacctat gctgacctgg acatggtcca cctcaaccgg     1800

acccccaagc agccggcccc caagcctgag ccgtccttct cagagtacgc cagcgtccag     1860

gtcccgagga agtgaatggg accgtggttt gctctagcac ccatctctac gcgctttctt     1920

gtcccacagg gagccgccgt gatgagcaca gccaacccag ttcccggagg gctggggcgg     1980

tgcaggctct gggacccagg ggccagggtg gctcttctct ccccacccct ccttggctct     2040

ccagcacttc ctgggcagcc acggccccct ccccccacat tgccacatac ctggaggctg     2100

acgttgccaa accagccagg gaaccaacct gggaagtggc cagaactgcc tggggtccaa     2160

gaactcttgt gcctccgtcc atcaccatgt gggttttgaa gaccctcgac tgcctccccg     2220

atgctccgaa gcctgatctt ccagggtggg gaggagaaaa tcccacctcc cctgacctcc     2280

accacctcca ccaccaccac caccaccacc accaccacta ccaccaccac ccaactgggg     2340

ctagagtggg gaagatttcc cctttagatc aaactgcccc ttccatggaa aagctggaaa     2400

aaaactctgg aacccatatc caggcttggt gaggttgctg ccaacagtcc tggcctcccc     2460

catccctagg ctaaagagcc atgagtcctg gaggaggaga ggacccctcc caaaggactg     2520

gagacaaaac cctctgcttc cttgggtccc tccaagactc cctggggccc aactgtgttg     2580

ctccacccgg acccatctct cccttctaga cctgagcttg cccctccagc tagcactaag     2640

caacatctcg ctgtggacgc ctgtaaatta ctgagaaatg tgaaacgtgc aatcttgaaa     2700

ctgaggtgtt agaaaacttg atctgtggtg ttttgttttg ttttttttct taaaacaaca     2760

gcaacgtgat cttggctgtc tgtcatgtgt tgaagtccat ggttgggtct tgtgaagtct     2820

gaggtttaac agtttgttgt cctggaggga ttttcttaca gcgaagactt gagttcctcc     2880

aagtcccaga accccaagaa tgggcaagaa ggatcaggtc agccactccc tggagacaca     2940

gccttctggc tgggactgac ttggccatgt tctcagctga gccacgcggc tggtagtgca     3000

gccttctgtg accccgctgt ggtaagtcca gcctgcccag ggctgctgag ggctgcctct     3060

tgacagtgca gtcttatcga gacccaatgc ctcagtctgc tcatccgtaa agtggggata     3120

gtgaagatga cacccctccc caccacctct cataagcact ttaggaacac acagagggta     3180

gggatagtgg ccctggccgt ctatcctacc cctttagtga ccgcccccat cccggctttc     3240

tgagctgatc cttgaagaag aaatcttcca tttctgctct caaaccctac tgggatcaaa     3300

ctggaataaa ttgaagacag ccagggggat ggtgcagctg tgaagctcgg gctgattccc     3360

cctctgtccc agaaggttgg ccagagggtg tgacccagtt accctttaac ccccaccctt     3420

ccagtcgggt gtgagggcct gaccgggccc agggcaagca gatgtcgcaa gccctattta     3480

ttcagtcttc actataactc ttagagttga gacgctaatg ttcatgactc ctggccttgg     3540

gatgcccaag ggatttctgg ctcaggctgt aaaagtagct gagccatcct gcccattcct     3600

ggaggtccta caggtgaaac tgcaggagct cagcatagac ccagctctct gggggatggt     3660

cacctggtga tttcaatgat ggcatccagg aattagctga gccaacagac catgtggaca     3720

gctttggcca gagctcccgt gtggcatctg ggagccacag tgacccagcc acctggctca     3780

ggctagttcc aaattccaaa agattggctt gtaaaccttc gtctccctct cttttaccca     3840

gagacagcac atacgtgtgc acacgcatgc acacacacat tcagtatttt aaaagaatgt     3900

tttcttggtg ccattttcat tttattttat tttttaattc ttggaggggg aaataaggga     3960

ataaggccaa ggaagatgta tagctttagc tttagcctgg caacctggag aatccacata     4020

ccttgtgtat tgaaccccag gaaaaggaag aggtcgaacc aaccctgcgg aaggagcatg     4080

gtttcaggag tttattttaa gactgctggg aaggaaacag gccccatttt gtatatagtt     4140

gcaacttaaa ctttttggct tgcaaaatat ttttgtaata aagatttctg ggtaataatg     4200

a                                                                     4201


