                         SEQUENCE LISTING

<110>  Proyecto de Biomedicina CIMA S.L.
 
<120>  New lung cancer markers

<130>  P2219PC00

<150>  EP12382113.4
<151>  2012-03-29

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  Homo sapiens

<300>
<308>  Uniprot / P0C0L4
<309>  1986-07-21
<313>  (957)..(1336)

<400>  1

Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly 
1               5                   10                  15      


Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr 
            20                  25                  30          


Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu 
        35                  40                  45              


Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro 
    50                  55                  60                  


Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr 
65                  70                  75                  80  


Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly 
                85                  90                  95      


Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 
            100                 105                 110         


Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys 
        115                 120                 125             


Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu 
    130                 135                 140                 


Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser 
145                 150                 155                 160 


Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser Met Gln Gly Gly Leu 
                165                 170                 175     


Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala 
            180                 185                 190         


Leu His His Gly Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu 
        195                 200                 205             


Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly 
    210                 215                 220                 


Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr 
225                 230                 235                 240 


Ala Tyr Ala Leu Ser Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val 
                245                 250                 255     


Ala His Asn Asn Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu 
            260                 265                 270         


Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr 
        275                 280                 285             


Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu 
    290                 295                 300                 


Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu 
305                 310                 315                 320 


Gly Lys Ala Glu Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln 
                325                 330                 335     


Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 
            340                 345                 350         


Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu 
        355                 360                 365             


Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg 
    370                 375                 380 


<210>  2
<211>  380
<212>  PRT
<213>  Homo sapiens

<300>
<308>  Uniprot / P0C0L5
<309>  1986-07-21
<313>  (957)..(1336)

<400>  2

Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly 
1               5                   10                  15      


Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr 
            20                  25                  30          


Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu 
        35                  40                  45              


Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro 
    50                  55                  60                  


Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr 
65                  70                  75                  80  


Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly 
                85                  90                  95      


Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 
            100                 105                 110         


Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu Lys 
        115                 120                 125             


Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys Leu 
    130                 135                 140                 


Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala Asp Gly Ser 
145                 150                 155                 160 


Phe Gln Asp Leu Ser Pro Val Ile His Arg Ser Met Gln Gly Gly Leu 
                165                 170                 175     


Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala Phe Val Thr Ile Ala 
            180                 185                 190         


Leu His His Gly Leu Ala Val Phe Gln Asp Glu Gly Ala Glu Pro Leu 
        195                 200                 205             


Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala Asn Ser Phe Leu Gly 
    210                 215                 220                 


Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His Ala Ala Ala Ile Thr 
225                 230                 235                 240 


Ala Tyr Ala Leu Ser Leu Thr Lys Ala Pro Val Asp Leu Leu Gly Val 
                245                 250                 255     


Ala His Asn Asn Leu Met Ala Met Ala Gln Glu Thr Gly Asp Asn Leu 
            260                 265                 270         


Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr 
        275                 280                 285             


Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu 
    290                 295                 300                 


Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu 
305                 310                 315                 320 


Gly Lys Ala Glu Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln 
                325                 330                 335     


Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 
            340                 345                 350         


Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu Glu 
        355                 360                 365             


Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg 
    370                 375                 380 


<210>  3
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile 
1               5                   10                  15      


Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr 
            20                  25                  30          


Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr 
        35                  40                  45              


Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys 
    50                  55                  60                  


Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His 
65                  70                  75                  80  


Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg 
                85                  90                  95      


Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His 
            100                 105                 110         


Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala 
        115                 120                 125             


Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser 
    130                 135                 140                 


Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys Val Val Ala Arg 
145                 150                 155                 160 


Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln 
                165                 170                 175     


Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu 
            180                 185                 190         


Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser 
        195                 200                 205             


Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
    210                 215                 220                 


Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
225                 230                 235                 240 


Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
                245                 250                 255     


Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
            260                 265                 270         


Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
        275                 280                 285             


Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
    290                 295                 300                 


Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr 
305                 310                 315                 320 


Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
                325                 330                 335     


Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
            340                 345                 350         


Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu 
        355                 360                 365             


Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
    370                 375                 380                 


Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
385                 390                 395                 400 


Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
                405                 410                 415     


Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
            420                 425                 430         


Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Ser Leu Thr Lys 
        435                 440                 445             


Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met 
    450                 455                 460                 


Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
465                 470                 475                 480 


Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
                485                 490                 495     


Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
            500                 505                 510         


Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
        515                 520                 525             


Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
    530                 535                 540                 


Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
545                 550                 555                 560 


Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
                565                 570                 575     


Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn 
            580                 585                 590         


Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser 
        595                 600                 605             


Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val 
    610                 615                 620                 


Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp 
625                 630                 635                 640 


Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu 
                645                 650                 655     


Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 
            660                 665                 670         


Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe 
        675                 680                 685             


Glu Gly 
    690 


<210>  4
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile 
1               5                   10                  15      


Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr 
            20                  25                  30          


Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr 
        35                  40                  45              


Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys 
    50                  55                  60                  


Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His 
65                  70                  75                  80  


Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg 
                85                  90                  95      


Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His 
            100                 105                 110         


Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala 
        115                 120                 125             


Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser 
    130                 135                 140                 


Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys Val Val Ala Arg 
145                 150                 155                 160 


Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln 
                165                 170                 175     


Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu 
            180                 185                 190         


Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser 
        195                 200                 205             


Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
    210                 215                 220                 


Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
225                 230                 235                 240 


Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
                245                 250                 255     


Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
            260                 265                 270         


Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
        275                 280                 285             


Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
    290                 295                 300                 


Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr 
305                 310                 315                 320 


Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
                325                 330                 335     


Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
            340                 345                 350         


Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile 
        355                 360                 365             


His Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
    370                 375                 380                 


Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
385                 390                 395                 400 


Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
                405                 410                 415     


Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
            420                 425                 430         


Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Ser Leu Thr Lys 
        435                 440                 445             


Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met 
    450                 455                 460                 


Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
465                 470                 475                 480 


Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
                485                 490                 495     


Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
            500                 505                 510         


Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
        515                 520                 525             


Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
    530                 535                 540                 


Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
545                 550                 555                 560 


Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
                565                 570                 575     


Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn 
            580                 585                 590         


Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser 
        595                 600                 605             


Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val 
    610                 615                 620                 


Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp 
625                 630                 635                 640 


Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu 
                645                 650                 655     


Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 
            660                 665                 670         


Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe 
        675                 680                 685             


Glu Gly 
    690 


<210>  5
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      


Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          


Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              


Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  


Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg 
65                  70                  75          


