               SEQUENCE LISTING

<110> Novo Nordisk A/S

<120> FVIIa-sTF complexes exhibiting exosite-mediated superactivity

<130> 8479

<140> EP12162483.7
<141> 2012-03-30

<160> 12

<170> BiSSAP 1.0

<210> 1
<211> 406
<212> PRT
<213> Homo sapiens

<220> 
<221> MOD_RES
<222> 6..7
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 14..14
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 16..16
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 19..20
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 25..26
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 29..29
<223> Xaa = GLA

<220> 
<221> MOD_RES
<222> 35..35
<223> Xaa = GLA

<220> 
<221> SOURCE
<222> 1..406
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Ala Asn Ala Phe Leu Xaa Xaa Leu Arg Pro Gly Ser Leu Xaa Arg Xaa 
1               5                   10                   15    
Cys Lys Xaa Xaa Gln Cys Ser Phe Xaa Xaa Ala Arg Xaa Ile Phe Lys 
            20                   25                  30        
Asp Ala Xaa Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                   40                  45            
Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                   55                  60                
Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                   70                  75                  80
Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                   90                  95    
Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                  105                110        
Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                  120                125            
Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                  135                140                
Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                  150                155                  160
Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                  170                175    
Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                  185                190        
His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                  200                205            
Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                  215                220                
Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                  230                235                  240
His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                  250                255    
His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                  265                270        
Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                  280                285            
Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                  295                300                
Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                  310                315                  320
Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                  330                335    
Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                  345                350        
Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                  360                365            
Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                  375                380                
Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                  390                395                  400
Leu Arg Ala Pro Phe Pro 
                405    

<210> 2
<211> 1335
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1335
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<220> 
<221> sig_peptide
<222> 1..114

<400> 2
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct      60

gcagtcttcg taacccagga ggaagcccaa ggcgtcctgc accggcgccg gcgcgccaac     120

gcgttcctgg aggagctgcg gccgggctcc ctggagaggg agtgcaagga ggagcagtgc     180

tccttcgagg aggcccggga gatcttcaag gacgcggaga ggacgaagct gttctggatt     240

tcttacagtg atggggacca gtgtgcctca agtccatgcc agaatggggg ctcctgcaag     300

gaccagctcc agtcctatat ctgcttctgc ctccctgcct tcgagggccg gaactgtgag     360

acgcacaagg atgaccagct gatctgtgtg aacgagaacg gcggctgtga gcagtactgc     420

agtgaccaca cgggcaccaa gcgctcctgt cggtgccacg aggggtactc tctgctggca     480

gacggggtgt cctgcacacc cacagttgaa tatccatgtg gaaaaatacc tattctagaa     540

aaaagaaatg ccagcaaacc ccaaggccga attgtggggg gcaaggtgtg ccccaaaggg     600

gagtgtccat ggcaggtcct gttgttggtg aatggagctc agttgtgtgg ggggaccctg     660

atcaacacca tctgggtggt ctccgcggcc cactgtttcg acaaaatcaa gaactggagg     720

aacctgatcg cggtgctggg cgagcacgac ctcagcgagc acgacgggga tgagcagagc     780

cggcgggtgg cgcaggtcat catccccagc acgtacgtcc cgggcaccac caaccacgac     840

atcgcgctgc tccgcctgca ccagcccgtg gtcctcactg accatgtggt gcccctctgc     900

ctgcccgaac ggacgttctc tgagaggacg ctggccttcg tgcgcttctc attggtcagc     960

ggctggggcc agctgctgga ccgtggcgcc acggccctgg agctcatggt cctcaacgtg    1020

ccccggctga tgacccagga ctgcctgcag cagtcacgga aggtgggaga ctccccaaat    1080

atcacggagt acatgttctg tgccggctac tcggatggca gcaaggactc ctgcaagggg    1140

gacagtggag gcccacatgc cacccactac cggggcacgt ggtacctgac gggcatcgtc    1200

agctggggcc agggctgcgc aaccgtgggc cactttgggg tgtacaccag ggtctcccag    1260

tacatcgagt ggctgcaaaa gctcatgcgc tcagagccac gcccaggagt cctcctgcga    1320

gccccatttc cctag                                                     1335


<210> 3
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..219
<223> /mol_type="protein"
      /note="sTF (1-219)"
      /organism="Artificial Sequence"

<400> 3
Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                   15    
Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                   25                  30        
Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                   40                  45            
Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                   55                  60                
Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                   70                  75                  80
Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                   90                  95    
Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                  105                110        
Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                  120                125            
Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                  135                140                
Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                  150                155                  160
Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                  170                175    
Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                  185                190        
Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                  200                205            
Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                  215                

<210> 4
<211> 756
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..756
<223> /mol_type="DNA"
      /note="sTF (1-219)"
      /organism="Artificial Sequence"

<220> 
<221> sig_peptide
<222> 1..96

<400> 4
atggagaccc ctgcctggcc ccgggtcccg cgccccgaga ccgccgtcgc tcggacgctc      60

ctgctcggct gggtcttcgc ccaggtggcc ggcgcttcag gcactacaaa tactgtggca     120

gcatataatt taacttggaa atcaactaat ttcaagacaa ttttggagtg ggaacccaaa     180

cccgtcaatc aagtctacac tgttcaaata agcactaagt caggagattg gaaaagcaaa     240

tgcttttaca caacagacac agagtgtgac ctcaccgacg agattgtgaa ggatgtgaag     300

cagacgtact tggcacgggt cttctcctac ccggcaggga atgtggagag caccggttct     360

gctggggagc ctctgtatga gaactcccca gagttcacac cttacctgga gacaaacctc     420

ggacagccaa caattcagag ttttgaacag gtgggaacaa aagtgaatgt gaccgtagaa     480

gatgaacgga ctttagtcag aaggaacaac actttcctaa gcctccggga tgtttttggc     540

aaggacttaa tttatacact ttattattgg aaatcttcaa gttcaggaaa gaaaacagcc     600

aaaacaaaca ctaatgagtt tttgattgat gtggataaag gagaaaacta ctgtttcagt     660

gttcaagcag tgattccctc ccgaacagtt aaccggaaga gtacagacag cccggtagag     720

tgtatgggcc aggagaaagg ggaattcaga gaataa                               756


<210> 5
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..50
<223> /mol_type="DNA"
      /note="oAeLN023-f"
      /organism="Artificial Sequence"

<400> 5
gggggctcct gcaaggactg tctccagtcc tatatctgct tctgcctccc                50


<210> 6
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..50
<223> /mol_type="DNA"
      /note="oAeLN023-r"
      /organism="Artificial Sequence"

<400> 6
gggaggcaga agcagatata ggactggaga cagtccttgc aggagccccc                50


<210> 7
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..44
<223> /mol_type="DNA"
      /note="oAeLN024-f"
      /organism="Artificial Sequence"

<400> 7
ggtcctcaac gtgccccgtc tagataccca ggactgcctg cagc                      44


<210> 8
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..44
<223> /mol_type="DNA"
      /note="oAeLN024-r"
      /organism="Artificial Sequence"

<400> 8
gctgcaggca gtcctgggta tctagacggg gcacgttgag gacc                      44


<210> 9
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..38
<223> /mol_type="DNA"
      /note="oHOJ152-f"
      /organism="Artificial Sequence"

<400> 9
ggcggcgggc tagcatggag acccctgcct ggccccgg                             38


<210> 10
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..42
<223> /mol_type="DNA"
      /note="oHOJ152-r"
      /organism="Artificial Sequence"

<400> 10
ccgccgccct cgagttattc tctgaattcc cctttctcct gg                        42


<210> 11
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..48
<223> /mol_type="DNA"
      /note="oAeLN015-f"
      /organism="Artificial Sequence"

<400> 11
ggagacaaac ctctgccagc caacaattca gagttttgaa caggtggg                  48


<210> 12
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..48
<223> /mol_type="DNA"
      /note="oAeLN015-r"
      /organism="Artificial Sequence"

<400> 12
cccacctgtt caaaactctg aattgttggc tggcagaggt ttgtctcc                  48


