                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Mascola, John R.
       Lynch, Rebecca M.
       Wu, Xueling
       Connors, Mark
       Zhou, Tongqing
       Casazza, Joseph
       Kwong, Peter D.
 
<120>  NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE

<130>  4239-89757-02

<150>  US 61/698,487
<151>  2012-09-07

<150>  PCT/US2012/030465
<151>  2012-03-23

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  X1 is M or I

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  X2 is I, S, V, or A

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  X3 is I or L

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X4 is L or V

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X5 is S or H

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X6 is T, S, or no amino acid

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  X7 is K, Q, or Y

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  X8 is T, L, A, or S

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  X9 is P or Q

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  X10 is T or S

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  X11 is Y or S

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  X12 is H or Q

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  X13 is R or H

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  X14 is F, R, Y, or V

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  X15 is E or D

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  X16 is P or S

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  X17 is N, T, or K

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  X18 is R, G, or Q

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  X19 is D, K, or E

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  X20 is N, A, H, S, or R

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  X21 is L, R, or P

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  X22 is E, R, or A

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  X23 is K or R

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  X24 is F or Y

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  X25 is F or L

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  X26 is L, M, F, or I

<400>  1

Gln Val Gln Leu Val Gln Pro Gly Thr Ala Met Lys Ser Leu Gly Ser 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Ser Gly Asp Asp Leu Gly Ser Phe 
            20                  25                  30          


His Phe Gly Thr Tyr Phe Xaa Xaa Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Gly Leu Glu Tyr Met Gly Gly Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Ala Xaa Lys Phe Xaa Gly Arg Val Ser Ile Ser Ala Pro Gly Val 
65                  70                  75                  80  


Pro Pro Val Leu Ser Leu Ala Leu Thr Asn Leu Thr Tyr Asp Asp Thr 
                85                  90                  95      


Ala Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Xaa Xaa Xaa Lys 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Asp Xaa Trp Gly Arg Gly 
        115                 120                 125             


Thr Phe Val Arg Val Ser Pro 
    130                 135 


<210>  2
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  X1 is A, T, N, or S

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  X2 is G, L, G, T, F, V, L, or A

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  X3 is R, G, or D

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  X4 is S or T

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  X5 is D, E, T, or A

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  X6 is R, D, Y, or S

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  X7 is Y, K, H, R or N

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  X8 is R, K, N, or S

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  X9 is S or P

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  X10 is H or W

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  X11 is A, R, N, or D

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Asn Ile Ser Cys Xaa Xaa Xaa Xaa Asp Xaa Xaa Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Gly Val Pro Lys Leu Leu Met Phe Asp Val Xaa 
        35                  40                  45              


Xaa Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser His Ser Gly 
    50                  55                  60                  


Asp Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Thr Xaa Xaa Pro Tyr Xaa Phe Gly Ala Gly Thr Lys 
                85                  90                  95      


Val Asn Val Leu 
            100 


<210>  3
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  X1 is N or S

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X2 is S or G

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X3 is A or G

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  X4 is G or T

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X5 is S or Y

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  X6 is A or G

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  X7 is V or T

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  X8 is T or P

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  X9 is F or Y

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  X10 is G or S

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  X11 is F or S

<400>  3

Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Xaa Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Xaa Xaa His Gly Xaa Xaa Xaa Tyr Phe Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp His Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Arg Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Xaa Xaa Xaa Tyr His Glu Xaa Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Xaa Trp Gly Gln Gly Thr Leu Val Ile Val Ser 
        115                 120                 125             


Ala 
    


<210>  4
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  X1 is G or A

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  X2 is H or R

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  X3 is Q or H

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  X4 is Q, G, or A

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  X5 is V or I

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  X6 is S or T

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Ser Gly Thr Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Xaa Ala Thr Asn Leu His Xaa Gly Val Ser Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly His Gly Thr His Phe Ser Leu Thr Ile Thr Asn Val Gln His 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Phe Cys Gln Xaa Ser Phe Xaa Thr Xaa Gly 
                85                  90                  95      


Xaa Phe Gly Gln Gly Thr Trp Val Asp Ile Arg 
            100                 105         


<210>  5
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Val Gln Pro Gly Thr Ala Met Lys Ser Leu Gly Ser 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Ser Gly Asp Asp Leu Gly Ser Phe 
            20                  25                  30          


His Phe Gly Thr Tyr Phe Met Ile Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Gly Leu Glu Tyr Met Gly Gly Ile Leu Pro Ser Thr Lys Thr Pro Thr 
    50                  55                  60                  


Tyr Ala His Lys Phe Arg Gly Arg Val Ser Ile Ser Ala Pro Gly Val 
65                  70                  75                  80  


Pro Pro Val Leu Ser Leu Ala Leu Thr Asn Leu Thr Tyr Asp Asp Thr 
                85                  90                  95      


Ala Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Phe Glu Pro Lys 
            100                 105                 110         


Asn Arg Asp Asn Leu Glu Gly Lys Phe Phe Asp Leu Trp Gly Arg Gly 
        115                 120                 125             


Thr Phe Val Arg Val Ser Pro 
    130                 135 


<210>  6
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Thr Ala Leu Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Thr Val Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Ile Ile Ile Ser Ala Gly Ala Gly Val Thr Pro Pro Val 
65                  70                  75                  80  


Val Ser Leu Gln Leu Thr Asn Leu Thr Phe Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Asp 
            100                 105                 110         


Ala Leu Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Val 
        115                 120                 125             


Ser Val Ser Ala 
    130         


<210>  7
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Leu Gln Leu Asp Gln Pro Gly Ala Ala Met Lys Ser Leu Gly Ser 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Arg Val Ser Gly Asp Asp Leu Gly Ser Phe 
            20                  25                  30          


His Phe Gly Thr Tyr Phe Met Ile Trp Val Arg Gln Gly Pro Gly Gln 
        35                  40                  45              


Gly Leu Glu Tyr Met Gly Gly Ile Leu Pro Ser Thr Lys Thr Pro Thr 
    50                  55                  60                  


Tyr Ala His Lys Phe Arg Gly Arg Val Ser Ile Ser Ala Pro Gly Val 
65                  70                  75                  80  


Pro Pro Val Leu Ser Leu Ala Leu Thr Asn Leu Thr Tyr Asp Asp Thr 
                85                  90                  95      


Ala Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Phe Glu Pro Lys 
            100                 105                 110         


Asn Arg Asp His Leu Glu Gly Lys Phe Leu Asp Leu Trp Gly Arg Gly 
        115                 120                 125             


Thr Phe Val Arg Val Ser Pro 
    130                 135 


<210>  8
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Arg Leu Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Phe Phe Ile Thr Gly Gly Val Thr Pro Pro Ile Ile Phe 
65                  70                  75                  80  


Leu Gln Leu Thr Asn Val Thr Phe Glu Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Lys Ser Leu 
            100                 105                 110         


Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Val Thr Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  9
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Pro Tyr Ile Val Gln Ser Gly Pro Ala Val Lys Gly Ala Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Thr Cys Lys Val Asp Gly Asp Asp Asp Gly Ile Phe 
            20                  25                  30          


Ser Phe Gly Thr Tyr Phe Met Val Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Gly Leu Gln Tyr Met Gly Gly Leu Val Pro Ser Tyr Ala Pro Thr Tyr 
    50                  55                  60                  


Ala His Lys Phe Glu Gly Arg Ile Thr Ile Ser Ala Ala Gly Thr Pro 
65                  70                  75                  80  


Pro Val Val Ser Leu Thr Leu Leu Asn Leu Thr Asn Asp Asp Ala Ala 
                85                  90                  95      


Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Tyr Asp Ser Lys Thr 
            100                 105                 110         


Arg Glu Asn Arg Arg Gly Arg Tyr Phe Asp Met Trp Gly Arg Gly Thr 
        115                 120                 125             


Arg Ile Thr Val Ser Pro 
    130                 


<210>  10
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Pro Tyr Ile Val Gln Ser Gly Pro Ala Val Lys Gly Ala Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Thr Cys Arg Val Asp Gly Asp Asp Asp Gly Ile Phe 
            20                  25                  30          


Asn Phe Gly Thr Tyr Phe Met Val Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Gly Leu Gln Tyr Met Gly Gly Leu Val Pro Ser Tyr Ala Pro Thr Tyr 
    50                  55                  60                  


Ala His Lys Phe Glu Gly Arg Ile Thr Ile Ser Ala Ala Gly Thr Pro 
65                  70                  75                  80  


Pro Val Val Ser Leu Thr Leu Ile Asn Leu Thr Asn Ala Asp Ala Ala 
                85                  90                  95      


Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Tyr Asp Ser Lys Thr 
            100                 105                 110         


Arg Glu Asn Arg Arg Gly Arg Tyr Phe Asp Met Trp Gly Arg Gly Thr 
        115                 120                 125             


Arg Ile Thr Val Ser Pro 
    130                 


<210>  11
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Ile Glu Leu Arg Gln Ser Gly Ala Ala Met Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Leu Gly Glu Asn Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Ile Lys Ile Ser Gly Gly Gly Thr Pro Pro Val Val Ser 
65                  70                  75                  80  


Leu Glu Leu Thr Asn Val Thr Phe Asp Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Arg Gly Arg His Val Glu Pro Lys Thr Gly Asp Arg Leu 
            100                 105                 110         


Ala Gly Arg Tyr Phe Asp Ile Trp Gly Arg Gly Thr Gly Leu Arg Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  12
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Thr Val Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Arg Phe 
    50                  55                  60                  


His Gly Arg Ile Thr Ile Ser Ala Gly Ala Gly Val Thr Pro Pro Val 
65                  70                  75                  80  


Val Ser Leu Gln Leu Thr Asn Leu Thr Phe Asp Asp Ala Gly Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Asp 
            100                 105                 110         


Ala Leu Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Ile 
        115                 120                 125             


Ser Val Ser Pro 
    130         


<210>  13
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Thr Ala Leu Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Thr Val Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Ile Ile Ile Ser Ala Gly Ala Gly Val Thr Pro Pro Val 
65                  70                  75                  80  


Val Ser Leu Gln Leu Thr Asn Leu Thr Phe Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Asp 
            100                 105                 110         


Ala Leu Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Leu 
        115                 120                 125             


Arg Val Ser Thr Ser 
    130             


<210>  14
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Thr Ala Leu Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Thr Val Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Ile Thr Ile Ser Ala Gly Ala Gly Val Thr Pro Pro Val 
65                  70                  75                  80  


Val Ser Leu Gln Leu Thr Asn Leu Thr Phe Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Asp 
            100                 105                 110         


Ala Leu Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Val 
        115                 120                 125             


Arg Val Ser Thr 
    130         


<210>  15
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Thr Ala Leu Lys Ser Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Leu Ser Cys Thr Val Leu Gly Asp Glu Phe Gly Thr Tyr 
            20                  25                  30          


Phe Ile Ser Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Val Pro His Ser Gln Leu Gln Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Ile Ile Ile Ser Ala Gly Ala Gly Val Thr Pro Pro Val 
65                  70                  75                  80  


Val Ser Leu Gln Leu Thr Asn Leu Thr Phe Glu Asp Thr Gly Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Arg Gly Arg His Arg Asp Pro Lys Thr Gly Lys 
            100                 105                 110         


Ala Pro Arg Gly Arg Tyr Phe Asp Phe Trp Gly Arg Gly Thr Gly Val 
        115                 120                 125             


Thr Val Ser Ala 
    130         


<210>  16
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Val Gln Pro Gly Thr Ala Met Lys Thr Leu Gly Ser 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Arg Val Ser Gly Asp Asp Gly Asn Phe His 
            20                  25                  30          


Phe Gly Thr Tyr Phe Met Ala Trp Val Arg Gln Val Pro Gly Gln Gly 
        35                  40                  45              


Leu Glu Tyr Met Gly Gly Ile Leu Pro Ser Thr Lys Ser Pro Thr Tyr 
    50                  55                  60                  


Ala His Lys Phe Arg Gly Arg Val Ser Ile Ser Thr Ala Gly Val Pro 
65                  70                  75                  80  


Pro Val Val Ser Leu Ala Leu Thr Asn Leu Thr Tyr Asp Asp Thr Ala 
                85                  90                  95      


Thr Tyr Phe Cys Ala Arg Glu Arg Gly Arg His Tyr Asp Ser Lys Lys 
            100                 105                 110         


Gln Glu Asn Tyr Arg Gly Lys Phe Phe Asp Leu Trp Gly Arg Gly Thr 
        115                 120                 125             


Trp Val Arg Val Ser Pro Thr 
    130                 135 


<210>  17
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Asn Ile Ser Cys Ala Gly Arg Ser Asp Arg Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Gly Val Pro Lys Leu Leu Met Phe Asp Val Tyr 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser His Ser Gly 
    50                  55                  60                  


Asp Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Thr Ser His Pro Tyr Ala Phe Gly Ala Gly Thr Lys 
                85                  90                  95      


Val Asn Val Leu Arg Gln 
            100         


<210>  18
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Ser Val Leu Thr Gln Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Thr Leu Gly Thr Glu Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Lys Arg Pro Ser Asp Val Ser Asp Arg Phe Ser Gly His Asn Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Leu Thr Ile Ser Glu Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Ser Trp Pro Tyr Arg Phe Gly Arg Gly Thr Lys 
                85                  90                  95      


Val Asp Val Ala 
            100 


<210>  19
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Asn Ile Ser Cys Ala Gly Arg Ser Asp Arg Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Gly Val Pro Lys Leu Leu Leu Phe Asp Val Tyr 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser His Ser Asp 
    50                  55                  60                  


Asp Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Thr Asp Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Thr Ser His Pro Tyr Ala Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Asn Val Leu 
            100 


<210>  20
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Val Leu Thr Gln Pro Ala Phe Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Asn Leu Gly Thr Asp Tyr Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Ser Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Asn Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Tyr Asn Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Tyr Cys Thr Ser Trp Pro Tyr Asn Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Asp Val Thr 
            100 


<210>  21
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Ser Ile Ser Cys Ser Gly Thr Phe Gly Ser Asp Ser Val Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Asn Ser Ala Pro Thr Leu Ile Ile Phe Asp 
        35                  40                  45              


Val His Arg Arg Pro Ser Gly Ile Ser Thr Arg Phe Ser Gly Ser Thr 
    50                  55                  60                  


Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Thr Leu His Arg Glu Asp 
65                  70                  75                  80  


Glu Ala Tyr Tyr Tyr Cys Thr Ser His Pro Tyr Asp Phe Gly Gly Gly 
                85                  90                  95      


Thr Tyr Val Ile Val Leu 
            100         


<210>  22
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Ser Ile Ser Cys Ser Gly Thr Phe Gly Ser Asp Ser Val Ser 
            20                  25                  30          


Trp Tyr Gln Gln Phe Pro Asn Ser Ala Pro Thr Leu Ile Ile Phe Asp 
        35                  40                  45              


Val His Arg Arg Pro Ser Gly Ile Ser Thr Arg Phe Ser Gly Ser Thr 
    50                  55                  60                  


Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Thr Leu His Arg Glu Asp 
65                  70                  75                  80  


Glu Ala Phe Tyr Tyr Cys Thr Ser His Pro Tyr Asp Phe Gly Gly Gly 
                85                  90                  95      


Thr Tyr Val Ile Val Leu 
            100         


<210>  23
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Ser Val Leu Thr Gln Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Val Gly Thr Thr Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ser Ser Asp 
    50                  55                  60                  


Asn Ala Ala Phe Leu Thr Ile Ala Gly Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Tyr Cys Thr Ser Trp Pro Tyr Arg Phe Gly Arg Gly Thr Lys 
                85                  90                  95      


Val Asp Val Gly 
            100 


<210>  24
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Ala Leu Thr His Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Thr Leu Gly Thr Glu Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Arg 
        35                  40                  45              


Lys Arg Pro Ser Glu Val Ser Asp Arg Phe Ser Gly His Lys Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Leu Thr Ile Ser Asp Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Ser Trp Pro Tyr Arg Phe Asp Arg Gly Thr Arg 
                85                  90                  95      


Leu Asp Val Ala 
            100 


<210>  25
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Ser Ala Leu Thr Gln Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Ser Leu Gly Thr Ala Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Lys Arg Pro Ser Asp Val Ser Asp Arg Phe Ser Gly His Asn Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Val Thr Ile Ser Glu Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Ser Trp Pro Tyr Arg Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Asp Val Ala Arg Gln 
            100         


<210>  26
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Ser Ala Leu Thr Gln Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Thr Leu Gly Thr Glu Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Lys Arg Pro Ser Asp Val Ser Asp Arg Phe Ser Gly His Asn Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Leu Thr Ile Ser Glu Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Ser Trp Pro Tyr Arg Phe Gly Arg Gly Thr Lys 
                85                  90                  95      


Val Asp Val Ala 
            100 


<210>  27
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Ser Ala Leu Thr Gln Pro Ala Phe Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Leu Ser Cys Thr Leu Gly Thr Glu Asp Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Arg Leu Ile Ile Phe Asp Val Lys 
        35                  40                  45              


Lys Arg Pro Ser Asp Val Ser Asp Arg Phe Ser Gly His Asn Ser Asp 
    50                  55                  60                  


Thr Ala Ala Phe Leu Thr Ile Ser Glu Leu Arg Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Thr Ser Trp Pro Tyr Arg Phe Asp Arg Gly Thr Lys 
                85                  90                  95      


Val Asp Val Ala 
            100 


<210>  28
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Ala Asp Ser Asp Tyr Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Asn Ser Ala Pro Lys Leu Ile Leu Phe Asp Val Asn 
        35                  40                  45              


Ser Arg Pro Ser Gly Val Ser Asp Arg Tyr Ser Gly Ser Arg Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Arg Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Thr Pro Trp Pro Tyr Asp Phe Arg Pro Gly Thr Arg 
                85                  90                  95      


Val Phe Val Leu Gly Gln 
            100         


<210>  29
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Ser Ala His Gly Gly Ser Ala Tyr Phe Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp His Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Arg Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Val Thr Phe Tyr His Glu Gly Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Ile Val Ser 
        115                 120                 125             


Ala 
    


<210>  30
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Gly Gly His Gly Thr Tyr Gly Tyr Tyr Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ser Met Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Pro Tyr Tyr His Glu Ser Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Phe Trp Gly Lys Gly Thr Leu Val Ile Val Ser 
        115                 120                 125             


Ala 
    


<210>  31
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Ser Ala His Gly Gly Ser Ala Tyr Tyr Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp His Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Arg Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Val Thr Phe Tyr His Glu Gly Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Ser Trp Gly Lys Gly Thr Arg Val Val Val Ser 
        115                 120                 125             


Ala 
    


<210>  32
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Ser Ala His Gly Gly Ser Ala Tyr Tyr Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp His Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Gly Leu Thr Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Val Thr Phe Tyr His Glu Gly Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Ser Trp Gly Lys Gly Thr Arg Val Val Val Ser 
        115                 120                 125             


Ala 
    


<210>  33
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Ser Gly Thr Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Thr Asn Leu His His Gly Val Ser Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly His Gly Thr His Phe Ser Leu Thr Ile Thr Asn Val Gln His 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Phe Cys Gln Gln Ser Phe Gln Thr Val Gly 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Trp Val Asp Ile Arg 
            100                 105         


<210>  34
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Ser Gly Thr Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu His Arg Gly Val Ser Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Thr Ile Thr Asn Val Gln Tyr 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Phe Cys Gln His Ser Phe Gly Thr Ile Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Trp Val Asp Ile Arg 
            100                 105         


<210>  35
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Ser Gly Thr Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu His Arg Gly Val Ser Pro Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly His Gly Thr His Phe Ser Leu Thr Ile Thr Asn Val Gln His 
65                  70                  75                  80  


Glu Asp Phe Gly His Tyr Phe Cys Gln Gln Ser Phe Ala Thr Val Gly 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Trp Val Asp Ile Arg 
            100                 105         


<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Lys Lys Ser Gly Thr Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu His Arg Gly Val Ser Pro Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly His Gly Thr His Phe Ser Leu Thr Ile Thr Asn Val Gln His 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Phe Cys Gln Gln Ser Phe Ala Thr Val Gly 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Trp Val Asp Ile Arg 
            100                 105         


<210>  37
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  37
caggtgcagc tggtgcagcc cgggactgcg atgaagtctc ttggatcatc actgacgatc       60

acttgcagag tctccggaga cgacctcggc tctttccact tcggcactta ttttatgatc      120

tgggtgcgtc aagcccctgg acagggcctt gagtacatgg gaggcatcct cccctccacg      180

aagacaccca cttacgcgca caaatttcga ggccgcgtct ctatttccgc tcccggggtt      240

ccgcccgtgc tgtccctcgc gctgaccaac ctcacatacg acgacacggc cacctacttc      300

tgtgcgcgcg agagggggcg acattttgag ccaaagaaca gggataatct ggaaggcaaa      360

tttttcgatt tatggggtcg tggcaccttc gttcgcgtct cgccg                      405


<210>  38
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  38
caggtgcagc ttgtgcagtc tgggactgcg ctgaagagcc ctggatcttc ggcgaagctc       60

tcctgcacag tccttggaga tgaatttggt acttatttca taagttggat tcgacaggcc      120

cctggacaag gacttgagtg ggtgggaggc atcgtccctc actctcagtt acagagctcc      180

gcgcagaagt ttcatggtcg aatcatcatt agcgcgggcg cgggcgtgac tccacccgtt      240

gtgtctctac aattgaccaa ccttacattt gaggacaccg gcacttattt ctgtgcgcgc      300

gagaggggac gacaccgtga tccgaagacg ggagatgccc tccgcggccg atacttcgat      360

ttctggggcc gtggcaccgg cgtcagcgtc tccgcg                                396


<210>  39
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  39
cagctgcaac tggaccagcc tggggctgcg atgaagtctc ttggatcatc actgaccatc       60

acttgcagag tctccggaga cgacctcggc tccttccact tcggcactta ttttatgatc      120

tgggtgcgtc aaggccctgg acagggcctt gagtacatgg gaggcatcct cccttccacg      180

aagacaccca cttacgcgca caaatttcga ggccgcgtct ctatttccgc tcccggggtt      240

ccgcccgtgt tgtccctcgc actgaccaac ctcacctacg acgacacggc cacctatttc      300

tgtgcgcgcg agaggggccg acattttgag ccaaagaaca gggatcatct cgaaggcaaa      360

tttttggatc tctggggtcg tggcaccttc gttcgtgtct cgccg                      405


<210>  40
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  40
caggtgcagt tagtgcagtc tggggctgtg gtgaagagcc ctggatcttc ggcgaagctc       60

tcctgcagac tccttggaga tgaatttggc acttatttca taagctggat tcgacaggcc      120

ccgggacgag gacttgagtg ggtgggaggc atcgtccctc actctcaatt acagagttcc      180

gcgcagaaat ttcatggtcg attcttcatc accgggggcg tgactccacc cattatattt      240

ctgcaattga ctaacgtaac atttgaggac accggcactt acttctgtgc gcgcgagagg      300

ggacgacacc gcgatccgaa gacgggaaaa tccctccgcg gccgatattt cgatttctgg      360

ggccgtggca ccggcgtcac cgtctccccg                                       390


<210>  41
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  41
cagccgtaca tagtacagtc tgggcctgcc gtgaaggggg ctggatcgtc ggtgaccgtc       60

acttgcaagg tcgatggaga cgacgacggc attttcagtt tcggcactta tttcatggtc      120

tgggtgcgac aggcccctgg acaaggactt caatatatgg gcggcctcgt cccttcctat      180

gcacccactt acgcgcacaa atttgaaggc cgaatcacta tttccgcggc cgggaccccg      240

cccgtcgtgt cgctgacact gctcaacctc acaaatgacg acgcggccac ttatttttgt      300

gcgcgcgaga gggggcgaca ttacgattca aagactcgag aaaatcgccg tggccgctat      360

ttcgacatgt ggggccgggg cactcggatc actgtctccc cg                         402


<210>  42
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  42
cagccgtaca tagtacagtc tgggcctgcc gtgaaggggg ctggatcgtc ggtgaccgtc       60

acttgcaggg tcgatggaga cgacgacggc attttcaatt tcggcactta tttcatggtc      120

tgggtgcgac aggcccctgg acaaggactt caatatatgg gcggcctcgt cccttcctat      180

gcacccactt acgcgcacaa atttgaaggc cgaatcacta tttccgcggc cgggaccccg      240

cccgtcgtgt ccctgacact gatcaacctc acaaatgccg acgcggccac ttatttttgt      300

gcgcgcgaga gggggcgaca ttacgattca aagactcgag aaaatcgccg tggccgctat      360

ttcgacatgt ggggccgggg cactcggatc actgtctccc cg                         402


<210>  43
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  43
cagatagaat tgaggcagtc tggggctgcg atgaagagcc ctggatcttc ggtgaagctc       60

tcctgcacag tccttggaga aaatttcggc acttatttca taagttggat tcgacaggcc      120

cctggacaag gacttgagtg ggtgggaggc atcgtccctc attctcaatt acaaagttcc      180

gcacagaagt ttcatggtcg aatcaaaatc agcgggggcg ggacgccgcc tgttgtgtcc      240

ctagaactga ctaatgttac atttgacgac accggcacct acttctgtgc gcgcgagagg      300

ggacgacacg ttgaaccgaa gacgggcgac cgcctcgccg gccgatactt cgacatctgg      360

ggccgtggca ccggactccg cgtctccccg                                       390


<210>  44
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  44
caggtgcagc tagtgcagtc tggggctgcg gtgaagagcc ctggatcttc ggcgaagctc       60

tcctgcacag tccttggaga tgaatttggt acttatttca taagttggat tcgacaggcc      120

cccggacaag gacttgagtg ggtgggaggc atcgtccctc actctcaatt acagagttcc      180

gcgcagaggt ttcatggtcg aatcactatc agcgcgggcg cgggcgtgac tccgcccgtt      240

gtgtctctac aattgaccaa tcttacattt gatgacgccg gcacttattt ctgcgcgcgc      300

gagaggggac gacaccgtga tccgaagacg ggagatgccc tccgcggccg atatttcgat      360

ttctggggcc gtggcaccgg catcagcgtc tccccg                                396


<210>  45
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  45
caggtgcagc tggtgcagtc tgggactgcg ctgaagagcc ctggatcttc ggcgaagctc       60

tcctgcacag tccttggaga tgaatttggt acttatttca taagttggat tcgacaggcc      120

cctggacaag gacttgagtg ggtgggaggc atcgtccctc actctcagtt acagagctcc      180

gcgcagaagt ttcatggtcg aatcatcatt agcgcgggcg cgggcgtgac tccacccgtt      240

gtgtctctac aattgaccaa ccttacattt gaagacaccg gcacttattt ctgtgcgcgc      300

gagaggggac gacaccgtga tccgaagacg ggagatgccc tccgcggccg atatttcgat      360

ttctggggcc gtggcaccgg cctcagagtc tccacg                                396


<210>  46
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  46
caggtgcagc tggtgcagtc tgggactgcg ctgaagagcc ctggatcttc ggcgaagctc       60

tcctgcacag tccttggaga tgaatttggt acttacttca taagctggat tcgacaggcc      120

cctggacaag gacttgagtg ggtgggaggc atcgtccctc actctcagtt acagagttcc      180

gcgcagaagt ttcatggtcg aatcaccatt agcgcgggcg cgggcgtgac tccacccgtt      240

gtgtctctac aattgaccaa ccttacattt gaggataccg gcacttattt ctgtgcgcgc      300

gagaggggac gacaccgtga tccgaagacg ggagatgccc tccgcggccg atatttcgat      360

ttctggggcc gtggcaccgg cgtcagggtc tccacg                                396


<210>  47
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  47
caggtgcagc tggtgcagtc tgggactgcg ctgaagagcc ctggatcttc ggcgaagctc       60

tcctgcacag tccttggaga tgaatttggt acttatttca taagttggat tcgacaggcc      120

cctggacaag gacttgagtg ggtgggaggc atcgtccctc actctcagtt acagagctcc      180

gcgcagaagt ttcatggtcg aatcatcatt agcgcgggcg cgggcgtgac tccacccgtt      240

gtgtctctac aattgaccaa ccttacattt gaggacaccg gcacttattt ctgtgcgcgc      300

gagaggggac gacaccgtga tccgaagacg ggaaaagccc cccgcggccg gtatttcgat      360

ttctggggcc gtggcaccgg cgtcaccgtc tccgcg                                396


<210>  48
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  48
caggtgcagc tggtgcagcc tgggactgcg atgaagactc tgggatcatc actgacgatc       60

tcctgtaggg tttctggaga cgacggcaac ttccatttcg ggacttattt tatggcttgg      120

gtgcggcaag tccctggaca aggccttgaa tatatgggag ggatcctccc ttccaccaaa      180

tcgcccacct acgcgcacaa atttcgaggc cgggtctcta tttccactgc cggggttccg      240

cccgtagtgt ccctcgctct gaccaatctc acatacgacg acacggccac ttatttttgt      300

gcgcgagaga gggggcgaca ctatgactca aaaaaacagg aaaattatcg cggcaaattt      360

ttcgatcttt ggggccgtgg cacctgggtc cgagtttcgc ca                         402


<210>  49
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  49
cagtctgccc tgactcagcc ggcctccgtg tctgggagtc cgggtcagtc gattaacatc       60

tcctgcgctg gacgttctga ccgtgtctcc tggtaccaac aacgcccgaa cggcgtcccc      120

aaattattaa tgttcgatgt ctaccgtcga ccgtctggtg tttctgatcg cttctctggc      180

tcgcattccg gcgacacggc ctttttgacc atctctgggc tccagacgga ggacgaggct      240

gactactatt gtacctcaca tccttatgcc ttcggggctg ggaccaaggt caatgtcctc      300


<210>  50
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  50
cagtctgtgc tgactcagcc tgccttcgtg tctggttctc cggggcagtc catcaccctc       60

tcgtgcactt taggaactga ggatgtctct tggtatcaac aacggccaaa cagcgccccc      120

cgactaataa tttttgatgt caaaaagaga ccgtcggatg tctctgatcg cttctctggc      180

cacaactctg acactgcggc cttcctgacc atctctgaac tccggcctga ggacgaggct      240

gagtattttt gcacctcatg gccttatcgt ttcggccgtg ggaccaaggt cgatgtcgca      300


<210>  51
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  51
cagtctgtgc tgactcagcc ggcctccgtg tctgggagtc cgggtcagtc gattaacatc       60

tcctgcgctg gccgttctga ccgtgtctcc tggtaccaac agcgcccaaa cggcgtcccc      120

aaattattac tcttcgatgt ctaccgtcga ccgtcgggtg tttctgatcg cttctctggc      180

tcccattcgg acgacacggc ctttttgacc atctctgggc tccagacgga cgacgaggct      240

gactactatt gtacctcaca tccttatgcc ttcgggcctg ggaccaaggt caatgtcctc      300


<210>  52
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  52
cagtctgtgc tgactcagcc tgccttcgtg tctgcttctc cggggcagtc catcaccctc       60

tcgtgcaatt tagggactga ctatgtctct tggtatcaac aacggccaag cagcgccccc      120

cgactaataa tttttgatgt caaaaatcga ccgtcgggtg tctctgatcg cttctctggt      180

tacaactctg acactgcggc cttcctgacc atctctggac tccagcctga ggacgaggct      240

gaatattatt gcacctcatg gccttataat ttcggccctg ggaccaaggt cgatgtcaca      300


<210>  53
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  53
cagtctgtgc tgactcagcc agcctctgtg tctgggtctc cgggtcagac catctccatc       60

tcctgcagtg ggactttcgg ctctgactct gtgtcttggt atcaacaata cccgaattcc      120

gcccccacac ttatcatttt tgatgtccac cgtcgaccct caggcatttc tactcgcttc      180

tctggctcca cgtctggcga cacagcctcc ctcaccatct ctacactcca cagagaggac      240

gaggcctatt attactgcac atcgcatccc tatgatttcg gaggtggcac ctacgtcatt      300

gtccta                                                                 306


<210>  54
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  54
cagtctgtcc tgactcagcc agcctctgtg tctgggtctc cgggtcagac catctccatc       60

tcctgcagtg ggactttcgg ctctgactct gtgtcttggt atcaacaatt cccaaattcc      120

gcccccacac ttatcatttt tgatgtccac cgtcgaccct caggcatttc tactcgcttc      180

tctggctcca catctggcga cacagcctcc ctcaccatct ctacactcca cagagaggac      240

gaggcctttt attactgcac atcgcatccc tatgatttcg gaggtggcac ctacgtcatt      300

gtccta                                                                 306


<210>  55
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  55
cagtctgtgc tgactcagcc tgccttcgtg tctggttctc cggggcagtc aatcaccatt       60

tcgtgcactg ttggtactac cgatgtctcc tggtaccaac aacggccgaa cagcgccccc      120

cgactgataa tttttgatgt caaaaaacga ccgtcgggtg tctctgatcg cttctctggc      180

tccagttctg acaacgcggc cttcctgacc atcgctggac tccggcctga ggacgaagct      240

gaatattatt gcacttcctg gccttatcgt ttcggccgtg ggaccaaggt cgatgtcggg      300


<210>  56
<211>  301
<212>  DNA
<213>  Homo sapiens

<400>  56
cagtctgccc tgactcatcc tgccttcgtg tctggttctc cggggcagtc aatcaccctc       60

tcgtgcactt taggaacaga ggatgtctct tggtatcaac aacgaccaaa cagcgccccc      120

cgactaataa tttttgatgt cagaaaacgg ccgtcggagg tctctgatcg cttctcaggc      180

cacaagtctg acactgcggc cttcctgacc atctctgacc tccggcctga agacgaggct      240

gagtattttt gcacctcatg gccttatcgt ttcgaccgtg ggacgagact cgatgtcgca      300

c                                                                      301


<210>  57
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  57
cagtctgccc tgactcagcc tgccttcgtg tctggttctc cgggtcagtc catcaccctc       60

tcgtgctctt taggaactgc ggatgtctct tggtatcaac aacggccaaa cagcgccccc      120

cgactaataa tttttgatgt caaaaagaga ccgtcggatg tctctgatcg cttctctggt      180

cacaactctg acactgcggc cttcgtgacc atctctgaac tccggcctga ggacgaggct      240

gaatattttt gcacctcatg gccttatcgt ttcggccctg ggaccaaggt cgatgtcgca      300


<210>  58
<211>  301
<212>  DNA
<213>  Homo sapiens

<400>  58
cagtctgccc tgactcagcc tgccttcgtg tctggttctc cggggcagtc catcaccctc       60

tcgtgcactt taggaactga ggatgtctct tggtatcaac aacggccaaa cagcgccccc      120

cgactaataa tttttgatgt caaaaagaga ccgtcggatg tctctgatcg cttctctggc      180

cacaactctg acactgcggc cttcctgacc atctctgaac tccggcctga ggacgaggct      240

gagtattttt gcacctcatg gccttatcgt ttcggccgtg ggaccaaggt cgatgtcgca      300

c                                                                      301


<210>  59
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  59
cagtctgccc tgactcagcc tgccttcgtg tctggttctc cggggcagtc catcaccctc       60

tcgtgcactt taggaactga ggatgtctct tggtatcaac aacggccaaa cagcgccccc      120

cgactaataa tttttgatgt caaaaagaga ccgtcggatg tctctgatcg cttctctggc      180

cacaactctg acactgcggc cttcctgacc atctctgaac tccggcctga ggacgaggct      240

gactattttt gcacctcatg gccttatcgt ttcgaccgtg ggaccaaggt cgatgtcgca      300


<210>  60
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  60
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc cggggcagtc gattaccatc       60

tcctgcactg cagactctga ctatgtctcc tggtatcaac aacgcccgaa cagcgccccc      120

aaactcattc tttttgatgt caatagtcga ccctcaggag tttctgatcg atactctggc      180

tccaggtcag gcaacacggc ctccctgacc atctctggac tccagcgtga ggacgaggct      240

gattatttct gcaccccctg gccttatgac ttcagacctg ggacgagagt ctttgtctta      300


<210>  61
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  61
gaggtgcagt tatcagagtc ggggggaggc ttcgtaaagc cgggggggtc cctgagactc       60

tcctgtgagg cctctggatt caccttcaat aattatgcca tgggttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctgtg acgagtgctc atggtggtag tgcatacttt      180

ggagaattcg tgaagggccg cttcaccatg tccagagacc acttcataga cacggtctac      240

ttggaaatga acagactgac agtcgaggac acggccgtct actactgcgt cagagtgaca      300

ttttaccatg agggcagtgg ctactattat cgtgccggga attactttga ttcctggggc      360

cagggaaccc tagtcatcgt ctccgca                                          387


<210>  62
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  62
gaggtgcagt tatcagaatc cgggggaggc gtcgtaaagc ctggggggtc cctgagactc       60

tcctgtgagg cctctggatt caccttcagt aattatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctgtg acgggtggtc atggtactta tggatattat      180

ggagaattcg tgaagggccg gttcaccatc tccagagacc attccatgga cacggtctat      240

ttgcaaatga acagactgag agtcgaggac acggccgtct actactgcgt cagaacgcca      300

tattaccatg agtcaagtgg ctactattat cgtgccggta attactttga cttttggggc      360

aagggaactc tagtcatcgt ctccgca                                          387


<210>  63
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  63
gaggtgcagt tatcagagtc gggtggaggc ttcgtaaagc cgggggggtc cctgagactc       60

tcctgtgagg cctctggatt caccttcaat aattatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctgtg acgagtgctc atggtggtag tgcatactat      180

ggagaattcg tgaagggccg gttcaccatg tccagagacc atttcataga cacggtctac      240

ttggaaatga acagactgac agtcgaggac acggccgtct actactgcgt cagagtgaca      300

ttttaccatg agggcagtgg ctactattac cgtgccggta attactttga ctcctggggc      360

aagggaaccc gagtcgtcgt ctccgca                                          387


<210>  64
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  64
gaggtgcagt tatcagagtc gggtggaggc ttcgtaaagc cgggggggtc cctgagactc       60

tcctgtgagg cctctggatt caccttcaat aattatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctctgtg acgagtgctc atggtggtag tgcatactat      180

ggagaattcg tgaagggccg gttcaccatg tccagagacc atttcataga cacggtctat      240

ttggaaatga acggactgac agtcgaggac acggccgtct actactgcgt cagagtgaca      300

ttttaccatg agggcagtgg ctactattac cgtgccggta attactttga ctcatggggc      360

aagggaaccc gggtcgtcgt ctccgca                                          387


<210>  65
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  65
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctatagggga cagagtcacc       60

ataacttgtc gggcgagtca ggacattgcc aactatttaa attggtatca gaagaaatca      120

gggactcccc ctaaactcct catctttggt gcgaccaact tgcaccatgg ggtgtctccg      180

aggttcagtg gcagtggaca tgggacgcat ttcagtctca ccatcaccaa tgttcaacat      240

gaagacttcg ctaattattt ttgtcaacag agttttcaaa ccgttgggtc attcggccaa      300

gggacctggg tggacatcag a                                                321


<210>  66
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  66
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc       60

attacttgtc gggcaagtca ggacattgcc aactatttaa attggtatca gaagaaatca      120

gggacacccc ctaaactcct catctttgct gcgaccaact tacaccgtgg ggtgtctccg      180

aggttcagtg gcagtggatc tgggacacat ttcagtctca ccatcaccaa tgtgcaatat      240

gaagacttcg ctaattattt ttgtcagcat agttttggaa ccattgggac attcggccaa      300

gggacctggg tggacatcag a                                                321


<210>  67
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  67
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctatagggga cagagtcacc       60

ataacttgtc gggcgagtca ggacattgcc aattatttaa attggtatca gaagaaatca      120

gggactcccc ctaaactcct catctttgct gcgaccaact tgcaccgtgg ggtgtctccg      180

aggttcactg gcagtggaca tgggacgcat ttcagtctca ccatcaccaa tgtgcaacat      240

gaagacttcg gtcattattt ttgtcaacaa agttttgcaa ccgttgggtc attcggccaa      300

gggacctggg tggacatcag a                                                321


<210>  68
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  68
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctatagggga cagagtcacc       60

ataacttgtc gggcgagtca ggacattgcc aactatttaa attggtatca gaagaaatca      120

gggactcccc ctaaactcct catctttgct gcgaccaact tgcaccgtgg ggtgtctccg      180

aggttcactg gcagtggaca tgggacgcat ttcagtctca ccatcaccaa tgtgcaacat      240

gaagacttcg gtaattattt ttgtcaacag agttttgcaa ccgttgggtc attcggccaa      300

gggacctggg tggacatcag a                                                321


<210>  69
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  70
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  70

Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
1               5                   10                  15      


Ser 
    


<210>  71
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  71

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu 
            


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  72

Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
1               5                   10          


<210>  73
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  74
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  75
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  75

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  76
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  76

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  77
<211>  458
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified antibody heavy chain

<400>  77

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
        35                  40                  45              


Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
    50                  55                  60                  


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu Arg Gly Arg His Phe Glu Pro Lys Asn Arg Asp Asn Leu Glu Gly 
            100                 105                 110         


Lys Phe Phe Asp Leu Trp Gly Arg Gly Thr Phe Val Arg Val Ser Pro 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  78
<211>  212
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified antibody light chain

<400>  78

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser His Pro Tyr Ala 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Val Asn Val Leu Arg Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  79
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Modified antibody heavy chain

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Thr Phe Tyr His Glu Gly Ser Gly Tyr Tyr Tyr Arg Ala 
            100                 105                 110         


Gly Asn Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Ile Val Ser 
        115                 120                 125             


Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210>  80
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified antibody light chain

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Gln Thr Val Gly 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Trp Val Asp Ile Arg Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


