                         SEQUENCE LISTING

<110>  BIOGEN IDEC MA INC.
       SIMON, Kenneth
       CAMERON, Thomas
       RUSHE, Mia
       CARAVELLA, Justin
       KAYNOR, George  Campbell
 
<120>  JCV NEUTRALIZING ANTIBODIES

<130>  B1152.70022WO00

<140>  PCT/US13/31853
<141>  2013-03-15

<150>  61/613249
<151>  2012-03-20

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Val Asp Ile Pro Met Gly Cys Ser Trp Val Ile Leu Phe Leu Leu 
1               5                   10                  15      


Ser Gly Thr Ala Gly Val His Ser Glu Val Gln Leu Gln Gln Ser Gly 
            20                  25                  30          


Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Glu Ser 
    50                  55                  60                  


His Gly Lys Asn Leu Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly 
65                  70                  75                  80  


Gly Thr Arg Tyr Asp Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val 
                85                  90                  95      


Asp Lys Ser Ser Thr Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser His His Tyr Ala Ser 
        115                 120                 125             


Gly Asp Glu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Glu Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His His Tyr Ala Ser Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Glu Ser His Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  5
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Glu Cys Ser Trp Val Met Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Arg Thr Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Thr His Gly Lys Ile Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Val Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Thr Tyr Leu Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser His Asn Tyr Gly Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Tyr Ser 
    130                 135                 140     


<210>  6
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Arg Thr Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Thr His Gly Lys Ile Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Val Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Asn Tyr Gly Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Tyr Ser 
        115                 120         


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Glu Ser Gln Thr Gln Val Phe Ile Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Leu Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Leu Ala 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Pro Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Thr Asp Phe Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Leu Ala Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Pro Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Phe Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Leu Glu Trp Ser Trp Val Ile Leu Phe Leu Leu Ser Gly Thr Ala 
1               5                   10                  15      


Gly Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn 
    50                  55                  60                  


Leu Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140         


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Lys Ser His Thr Gln Val Phe Ile Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Cys Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
        115                 120                 125         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Cys 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
            100                 105         


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Ala Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Lys Gly Val Arg Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Ser Phe Val His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gln Ser Asn Glu Asp Pro Met Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Met Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Ser Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Ser Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Gln Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  19
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Gln Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asp Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  21
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asp Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  22
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr His Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  23
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr His Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Thr Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  25
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Thr Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  26
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Ala Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Ala Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Leu Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Leu Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Xaa Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Xaa Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  33
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Ala Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Val Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Val Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Pro Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Pro Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr Asn Xaa Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu Asp Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Xaa Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
        115                 120                 125         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
            100                 105         


<210>  42
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Ser Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
        115                 120                 125         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
            100                 105         


<210>  44
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Ala Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
        115                 120                 125         


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Ala 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
            100                 105         


<210>  46
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Xaa Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
        115                 120                 125         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Xaa 
                85                  90                  95      


Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg 
            100                 105         


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Gly Tyr Thr Leu Thr 
1               5   


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Leu Ile Asn Pro Tyr Ser Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Leu Ile Asn Pro Tyr Gln Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Leu Ile Asn Pro Tyr Asp Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  53

Leu Ile Asn Pro Tyr His Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Leu Ile Asn Pro Tyr Thr Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Leu Ile Asn Pro Tyr Ala Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Leu Ile Asn Pro Tyr Leu Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  57

Leu Ile Asn Pro Tyr Xaa Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Leu Ile Asn Pro Tyr Asn Ala Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  59

Leu Ile Asn Pro Tyr Asn Val Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Leu Ile Asn Pro Tyr Asn Pro Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Leu Ile Asn Pro Tyr Asn Xaa Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Leu Ile Asn Pro Tyr Xaa Xaa Gly Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe Asp Tyr 
1               5                   10              


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Gln Gln Tyr Ser Ser Tyr Pro Cys Thr 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Gln Gln Tyr Ser Ser Tyr Pro Ser Thr 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  69

Gln Gln Tyr Ser Ser Tyr Pro Ala Thr 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Gln Gln Tyr Ser Ser Tyr Pro Xaa Thr 
1               5                   


<210>  71
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  71

Met Asp Phe Gly Leu Ser Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Leu Thr Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Asp Trp Ile Gly Leu Ile Asn Pro Tyr His Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Tyr Tyr Ala Thr Gly Asp Glu Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  72
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  72

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Ser Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Arg Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  73
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  73
atggacttcg ggttgagctt ggttttcctt gtcctaattt taaaaggtgt ccagtgtgaa       60

gtgcagctgc agcagtccgg ccctgagctg gtgaaacctg gcgcctccat gaagatcagc      120

tgcaaggcct ccggctactc cttcaccggc tacaccctga cctgggtgaa acagtcccac      180

ggcaagaacc tggactggat cggcctgatc aacccctacc acggcggcac ccggtacaac      240

cagaagttca agggcaaggc caccctgacc gtggacaagt cctcctccac cgcctacatg      300

gaactgctgt ccctgacctc cgaggactcc gccgtgtact actgcgccag actgggctac      360

tacgccaccg gcgacgagta cttcgactac tggggccagg gcaccaccct gacagtgtcc      420

tccgcctcta ccaagggccc ctccgtgttc cctctggccc cctccagcaa gtccacctct      480

ggcggcaccg ccgctctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaagac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgttggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctcccggt                                      1410


<210>  74
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  74
atgagggtcc ccgctcagct cctggggctc cttctgctct ggctccctgg agccagatgt       60

gacatcgtga tgacccagtc ccacaagttc atgtccacct ccgtgggcga ccgggtgtcc      120

atcacatgca aggcctccca ggacgtgggc accgccgtgg cctggtatca gcagaagccc      180

ggccagtccc ccaagctgct gatctactgg gcctccacca gacacaccgg cgtgcccgac      240

agattcaccg gctccagatc cggcaccgac ttcaccctga ccatctccaa cgtgcagtcc      300

gaggacctgg ccgactactt ctgccagcag tactcctcct accccagcac cttcggcgga      360

ggcgccaagc tggaaatccg gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         702


