
                                SEQUENCE LISTING

<110> MERCK SHARP & DOHME CORP.
      Joseph G. JOYCE
      Chengwei WU
      Elizabeth A. OTTINGER
      Victor GARSKY
      

<120> STABLE PEPTIDE MIMETICS OF THE HIV-1
  GP41 PRE-HAIRPIN INTERMEDIATE
  

<130> 23202

<150>  60/613,264         
<151> 2012-03-20  

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human Immunodeficiency Virus Type I
      

<400> 1
Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala
 1               5                  10                  15      
Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln
            20                  25                  30          
Ala Arg Ile Leu
        35      


<210> 2
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human Immunodeficiency Virus Type I
      

<400> 2
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 3
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric HIV-1 N38 GP41 Sequence
      

<400> 3
Arg Gly Arg Gly Arg Gly Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Gly
        35                  40                  


<210> 4
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human Immunodeficiency Virus Type I
      
      

<400> 4
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 5
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human Immunodeficiency Virus Type I
      

<400> 5
Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln
 1               5                  10                  15      
Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile
            20                  25                  30          
Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln
        35                  40                  45              
Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp
    50                  55                  60          


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N17 HIV-1 GP41 Sequence
      

<400> 6
Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Ala Leu Ala Ala Ala Ile
 1               5                  10                  15      
Ala
    


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N17 HIV-1 GP41 Sequence
      

<400> 7
Leu Ile Gln Leu Ile Trp Gly Ile Lys Gln Ile Gln Ala Arg Ile Leu
 1               5                  10                  15      


<210> 8
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV1 GP41 Sequence
      

<400> 8
Gln Ile Arg Glu Leu Ile Ser Lys Ile Val Glu Gln Ile Asn Asn Ile
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Ala Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 9
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence

<400> 9
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Ala Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 10
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 10
Asn Ile Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 11
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 11
Gln Ala Arg Gln Leu Ile Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 12
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence

<400> 12
Gln Ile Arg Gln Leu Ile Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 13
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 13
Gln Ala Arg Gln Leu Leu Ser Ala Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 14
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 14
Gln Ile Arg Gln Leu Ile Ser Ala Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 15
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 15
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Ile Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 16
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 16
Asn Ile Arg Gln Leu Ile Ser Ala Ile Val Gln Gln Ile Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 17
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 17
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Val Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 18
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 18
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Ile Val Trp
            20                  25                  30          
Gly Val Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 19
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 19
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Ile Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 20
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 20
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Ile Glu Arg Tyr Ile
        35                  40                  45              
Lys Asp Gln
    50      


<210> 21
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 21
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp
            20                  25                  30          
Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Ile
    50      


<210> 22
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 22
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Ile Val Trp
            20                  25                  30          
Gly Val Lys Gln Ile Gln Ala Arg Ile Leu Ala Ile Glu Arg Tyr Ile
        35                  40                  45              
Lys Asp Ile
    50      


<210> 23
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 23
Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Val Val Trp
            20                  25                  30          
Gly Asn Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu
        35                  40                  45              
Lys Asp Gln
    50      


<210> 24
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutated N51 HIV-1 GP41 Sequence
      

<400> 24
Gln Ile Arg Gln Leu Ile Ser Gly Ile Val Gln Gln Ile Asn Asn Ile
 1               5                  10                  15      
Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Ile Val Trp
            20                  25                  30          
Gly Ile Lys Gln Ile Gln Ala Arg Ile Leu Ala Ile Glu Arg Tyr Ile
        35                  40                  45              
Lys Asp Gln
    50      


<210> 25
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type I
      

<400> 25
Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu
 1               5                  10                  15      
Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly
            20                  25                  30          
Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys
        35                  40                  45              


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type I
      

<400> 26
Ala Val Glu Arg Tyr Leu Lys
 1               5          


<210> 27
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type 1

<400> 27
Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile
 1               5                  10                  15      
Leu Ala Val Glu Arg Tyr Leu Lys
            20                  


<210> 28
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type 1

<400> 28
Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys
 1               5                  10                  15      
Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys
            20                  25                  30  


<210> 29
<211> 43
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type 1
      

<400> 29
Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala
 1               5                  10                  15      
Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln
            20                  25                  30          
Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys
        35                  40              


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HIV Type I
      

<400> 30
Ala Ser Gln Leu Leu
 1               5  


<210> 31
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Suzuki-1Z Coiled Coil Motif
      

<400> 31
Tyr Gly Gly Ile Glu Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu
 1               5                  10                  15      
Ala Ile Glu Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu Ala
            20                  25                  30      


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Suzuki-1Z Coiled Coil Motif
      
      

<400> 32
Ile Glu Lys Lys Ile Glu Ala
 1               5          


<210> 33
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1Z Domain
      

<400> 33
Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Gln
 1               5                  10                  15      
Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu
            20                  25                  30          
Arg
    


<210> 34
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Shorted 1Z-Like Domain 1Z17
      

<400> 34
Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Glu Ala Ile Lys Lys
 1               5                  10                  15      
Lys Ile Glu Ala Ile Glu Lys
            20              


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric N-Peptide 1ZN36
      

<400> 35
Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln Glu Ala Ile Lys
 1               5                  10                  15      
Lys
    


<210> 36
<211> 62
<212> PRT
<213> Artificial Sequence

<220> 
<223> E7 Scaftold Domain
      

<400> 36
Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln Glu Ala Ile Lys
 1               5                  10                  15      
Lys Lys Ile Glu Ala Ile Glu Lys Glu Ile Ser Gly Ile Val Gln Gln
            20                  25                  30          
Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln
        35                  40                  45              
Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu
    50                  55                  60          


<210> 37
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Bacteria Phage T4 Fibritin
      

<400> 37
Ile Lys Lys Ile Glu Glu Ile Glu Lys Lys Ile Glu Glu Ile Glu Lys
 1               5                  10                  15      
Lys Ile Glu Glu Ile Glu Lys
            20              


<210> 38
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Bacteria Phage T4 Fibritin
      

<400> 38
Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp
 1               5                  10                  15      
Gly Glu Trp Val Leu Leu Ser Thr Phe Leu
            20                  25      


<210> 39
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric N-Peptide SZN51
      

<400> 39
Ile Glu Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu Ala Ile Glu
 1               5                  10                  15      
Lys Lys Ile Glu Ala Ile Glu Lys Lys Ile Glu Gln Ala Arg Gln Leu
            20                  25                  30          
Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu
        35                  40                  45              
Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu
    50                  55                  60                  
Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln
65                  70                  75              


<210> 40
<211> 82
<212> PRT
<213> Artificial Sequence

<220> 
<223> CC-Chimeric N-Peptide CC1ZN51
      

<400> 40
Cys Cys Gly Gly Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln
 1               5                  10                  15      
Glu Ala Ile Lys Lys Lys Ile Glu Ala Ile Glu Lys Glu Ile Val Gln
            20                  25                  30          
Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu
        35                  40                  45              
Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly
    50                  55                  60                  
Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys
65                  70                  75                  80  
Asp Gln
        


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linear Scaffold
      

<221> MOD_RES        
<222> 1, 3, 5, 7
<223> delta-amino valeric acid

<400> 41
Xaa Lys Xaa Lys Xaa Lys Xaa
 1               5          


<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linear Scaffold
      

<400> 42
Arg Lys Arg Lys Arg Lys Arg
 1               5          


<210> 43
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linear Scaffold
      

<400> 43
Glu Lys Glu Lys Glu Lys Glu
 1               5          


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linear Scaffold
      

<400> 44
Cys His Cys Cys Arg Lys Arg Lys Arg Lys Arg Asn His
 1               5                  10              


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric N-Peptide CC1ZN36
      

<400> 45
Cys Glu Lys Glu Lys Glu Lys Glu
 1               5              


<210> 46
<211> 66
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric N-Peptide CC1ZN36
      

<400> 46
Cys Cys Gly Gly Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln
 1               5                  10                  15      
Glu Ala Ile Lys Lys Lys Ile Glu Ala Ile Glu Lys Glu Ile Ser Gly
            20                  25                  30          
Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln
        35                  40                  45              
His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg
    50                  55                  60                  
Ile Leu
65      

