                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
      THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC 
      HEART FAILURE

<130> 043214-073892-PCT

<140>
<141>

<150> 61/649,962
<151> 2012-05-22

<150> 61/612,550
<151> 2012-03-19

<160> 26    

<170> PatentIn version 3.5

<210> 1
<211> 407
<212> PRT
<213> Homo sapiens

<400> 1
Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210> 2
<211> 383
<212> PRT
<213> Homo sapiens

<400> 2
Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg 
        275                 280                 285             


Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp 
    290                 295                 300                 


Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln 
305                 310                 315                 320 


Cys Glu Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln 
                325                 330                 335     


Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys 
            340                 345                 350         


Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile 
        355                 360                 365             


Tyr Gly Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380             


<210> 3
<211> 4260
<212> DNA
<213> Homo sapiens

<400> 3
tccccgcccc ccagtcctcc ctcccctccc ctccagcatg gtgctcgcgg ccccgctgct       60

gctgggcttc ctgctcctcg ccctggagct gcggccccgg ggggaggcgg ccgagggccc      120

cgcggcggcg gcggcggcgg cggcggcggc ggcagcggcg ggggtcgggg gggagcgctc      180

cagccggcca gccccgtccg tggcgcccga gccggacggc tgccccgtgt gcgtttggcg      240

gcagcacagc cgcgagctgc gcctagagag catcaagtcg cagatcttga gcaaactgcg      300

gctcaaggag gcgcccaaca tcagccgcga ggtggtgaag cagctgctgc ccaaggcgcc      360

gccgctgcag cagatcctgg acctacacga cttccagggc gacgcgctgc agcccgagga      420

cttcctggag gaggacgagt accacgccac caccgagacc gtcattagca tggcccagga      480

gacggaccca gcagtacaga cagatggcag ccctctctgc tgccattttc acttcagccc      540

caaggtgatg ttcacaaagg tactgaaggc ccagctgtgg gtgtacctac ggcctgtacc      600

ccgcccagcc acagtctacc tgcagatctt gcgactaaaa cccctaactg gggaagggac      660

cgcaggggga gggggcggag gccggcgtca catccgtatc cgctcactga agattgagct      720

gcactcacgc tcaggccatt ggcagagcat cgacttcaag caagtgctac acagctggtt      780

ccgccagcca cagagcaact ggggcatcga gatcaacgcc tttgatccca gtggcacaga      840

cctggctgtc acctccctgg ggccgggagc cgaggggctg catccattca tggagcttcg      900

agtcctagag aacacaaaac gttcccggcg gaacctgggt ctggactgcg acgagcactc      960

aagcgagtcc cgctgctgcc gatatcccct cacagtggac tttgaggctt tcggctggga     1020

ctggatcatc gcacctaagc gctacaaggc caactactgc tccggccagt gcgagtacat     1080

gttcatgcaa aaatatccgc atacccattt ggtgcagcag gccaatccaa gaggctctgc     1140

tgggccctgt tgtaccccca ccaagatgtc cccaatcaac atgctctact tcaatgacaa     1200

gcagcagatt atctacggca agatccctgg catggtggtg gatcgctgtg gctgctctta     1260

aggtggggga tagaggatgc ctcccccaca gaccctaccc caagacccct agccctgccc     1320

ccatcccccc aagccctaga gctccctcca ctcttcccgc gaacatcaca ccgttccccg     1380

accaagccgt gtgcaataca acagagggag gcaggtggga attgagggtg aggggtttgg     1440

gggaaagggg aagcaggggc atagtcaggg tggggagtgt ttgaagtttg cagatgagaa     1500

ggtttgacaa aaagacagag agatgtagag acagtgatag agacagagga acaaaaagag     1560

cagcagtgag aaggcaaaga gagaggcaga agagacagac gaggcagaga caaaacactg     1620

agaaagagac tgaaatggag taataaatga aagccccaca ccaagcctcc tttcttccac     1680

tggcaaggtg aggggcttgg tatagtttgg ggagatcccc tgactattca gtaggagaag     1740

aaatcaaaaa tccattcttt tctccttctc tccctccaac agtggccagg ggaaggggaa     1800

gtgagggcag gggcaaaaag atttgggaat ttttatttat ttatttattg tgacttttca     1860

tttttttggt atttggcttt actggaatag gagggcccct gcccactgtg ccccgtttat     1920

cccttattcc ccaaaccctg ctctccccaa cacctactca cttaagcact tgtataaagc     1980

ctccagggtt gggaatggga gtaaagggca agagggcgga cacatgaagt ttagtttcta     2040

acccatcatc accctaactc aaccttttct gagccaaatg gcttgaattg aagccagttg     2100

tcatggaaat agtaagaggt tagggtttaa gagctgggga tgcgggggtg ggagagagaa     2160

ccctcaacat ccaggatcta tataatgaga gctactttaa accctcaggt ccaccctcat     2220

gatgctgagt tatttagcca gagggtgcag cctgcttatg cccaaattcc ctcagccaag     2280

agagagacca aagagcctct ggaatggccc tgctcccagc ctctatcttc aggtcaatta     2340

gagagagtat agagacccca gagtcccctg ggtctggaaa gcgttaggag aggtcaagaa     2400

aggagcagta aggaggctga aggttacagg gcatttgaat ccaaatcact gctctgggct     2460

agggaataga gccagcagac caaggtggga aggattctgg aagggggaca ttttagtctc     2520

ctaaccccaa agctcagggt ggaagagggg agaacaagga agcagagtgt ataattattt     2580

tttcctttta tttttggaat ctaacagtac ctggcagcag ggaggggaaa gtacagtggg     2640

gaaaagcatc tgacaaggcc agttagaaca gaggatggga aggatggaga ctcccgggct     2700

tggaaggcta ggaagcaggc agagactggt tgccatttca agtcactagc taggcccatt     2760

cattcctccc acaaccctga cccattctcc tctggactca ctgtgcctca gtttcttccc     2820

ctcaatggaa tgagaaatga cagcacccgc cacagccaag agatgaattc tgagcactta     2880

ccacgggcac tttatggaca taaaatacct ctcgctgtgg gacagataac cagggcacca     2940

gagtagtggt gaagagatgt gaggcttaag aggagtcaca ggcttcagag tacaagttcc     3000

cctctgcctc ccagctggac agtgcctaga agccaaggag ttgagaatct cctgatccac     3060

accctatcct tacttcacca ccaggcctct tggctccagg caagagctta gaggatgtca     3120

ggagaggtgg gggtaagaat cttcagcaaa actgtcactc taagtagagc cagcagttac     3180

gggtctgata aaaacagtac tgaactaaag taaagcccaa gctggtgagc aaaactggat     3240

ggctcattct tcccaagagc atgactctcc cccttggcca gttggtggaa ggggcaaagg     3300

tatgtgacca cccttgagaa ggtgatgttg gtgagcttta acatcttatt cctattctta     3360

tagtgagaaa gtgaaacaag atctttcagt agaggaatgg gcagggctgt taggctcttc     3420

agcttgcctt cacccatata gcagctatgc taaccccaag cctctctggc cctgttcttc     3480

atccttcctt ctgccccaat cctgaaggac aagacacacc cggccatcaa caccactcac     3540

atttccttgg tggaaggaaa ggaacagaga agtgaagaac agatacctcc ctccaaggtc     3600

aaatgcctcg tgatcttggc agagtaggga ttgggcaata agcatcaggt atcttccctc     3660

tacagattct agagagctgg ggcattaaat atgggggaca cttagaatac agctccttaa     3720

ataccaccaa ataaagacct ttgtgtgtgt gtggtgggtg gggggggggc aggggtcttt     3780

ctcttatgaa cataaatctg tgagctgaag tctcattccc ctgttcctcc ctacccccaa     3840

agaggcacag agtgaaggga cttggggggc acagctcagc aacccagtgg gagttagcac     3900

cccctcccac cttatgatgt gtgtggacct ggccagtgcc cctctgaaca tatcattatt     3960

agtgtaatta tcatttattt tgtgtatttg tcacattgtg tgcatgacag cctttgttaa     4020

gggtgtctga ggagtatgga gctgacaggg gcattggaat gccaggaaag aacttcttca     4080

actgagatca aggcttcctg gagggaacca ctgcaaaaag gccatcaggc agttttcaag     4140

ttatgtgaca gagggcaaag acggccatag ggtgctctga gttttgggat ggtcacatga     4200

cacaatccag cacttgaacc tgaaaaaaaa aataaaagcg gtcaaagagt ttagaattca     4260


<210> 4
<211> 247
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Met Gly Asp 
        35                  40                  45              


Lys Gly Gln Lys Gly Ser Val Gly Arg His Gly Lys Ile Gly Pro Ile 
    50                  55                  60                  


Gly Ser Lys Gly Glu Lys Gly Asp Ser Gly Asp Ile Gly Pro Pro Gly 
65                  70                  75                  80  


Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu Cys Ser Gln Leu Arg Lys 
                85                  90                  95      


Ala Ile Gly Glu Met Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu 
            100                 105                 110         


Lys Phe Ile Lys Asn Ala Val Ala Gly Val Arg Glu Thr Glu Ser Lys 
        115                 120                 125             


Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu 
    130                 135                 140                 


Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala 
145                 150                 155                 160 


Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg 
                165                 170                 175     


Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr 
            180                 185                 190         


Ser Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu 
        195                 200                 205             


Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser 
    210                 215                 220                 


Gly Gly Trp Asn Asp Val Ala Cys His Thr Thr Met Tyr Phe Met Cys 
225                 230                 235                 240 


Glu Phe Asp Lys Glu Asn Met 
                245         


<210> 5
<211> 412
<212> PRT
<213> Homo sapiens

<400> 5
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210> 6
<211> 224
<212> PRT
<213> Homo sapiens

<400> 6
Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu 
1               5                   10                  15      


Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu 
            20                  25                  30          


His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn 
        35                  40                  45              


Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala 
    50                  55                  60                  


Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys 
65                  70                  75                  80  


Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala 
                85                  90                  95      


Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala 
            100                 105                 110         


Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys 
        115                 120                 125             


Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser 
    130                 135                 140                 


Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His 
145                 150                 155                 160 


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys 
                165                 170                 175     


Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln 
            180                 185                 190         


Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser 
        195                 200                 205             


Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu 
    210                 215                 220                 


<210> 7
<211> 864
<212> PRT
<213> Homo sapiens

<400> 7
Met Thr Thr Glu Lys Ser Leu Val Thr Glu Ala Glu Asn Ser Gln His 
1               5                   10                  15      


Gln Gln Lys Glu Glu Gly Glu Glu Ala Ile Asn Ser Gly Gln Gln Glu 
            20                  25                  30          


Pro Gln Gln Glu Glu Ser Cys Gln Thr Ala Ala Glu Gly Asp Asn Trp 
        35                  40                  45              


Cys Glu Gln Lys Leu Lys Ala Ser Asn Gly Asp Thr Pro Thr His Glu 
    50                  55                  60                  


Asp Leu Thr Lys Asn Lys Glu Arg Thr Ser Glu Ser Arg Gly Leu Ser 
65                  70                  75                  80  


Arg Leu Phe Ser Ser Phe Leu Lys Arg Pro Lys Ser Gln Val Ser Glu 
                85                  90                  95      


Glu Glu Gly Lys Glu Val Glu Ser Asp Lys Glu Lys Gly Glu Gly Gly 
            100                 105                 110         


Gln Lys Glu Ile Glu Phe Gly Thr Ser Leu Asp Glu Glu Ile Ile Leu 
        115                 120                 125             


Lys Ala Pro Ile Ala Ala Pro Glu Pro Glu Leu Lys Thr Asp Pro Ser 
    130                 135                 140                 


Leu Asp Leu His Ser Leu Ser Ser Ala Glu Thr Gln Pro Ala Gln Glu 
145                 150                 155                 160 


Glu Leu Arg Glu Asp Pro Asp Phe Glu Ile Lys Glu Gly Glu Gly Leu 
                165                 170                 175     


Glu Glu Cys Ser Lys Ile Glu Val Lys Glu Glu Ser Pro Gln Ser Lys 
            180                 185                 190         


Ala Glu Thr Glu Leu Lys Ala Ser Gln Lys Pro Ile Arg Lys His Arg 
        195                 200                 205             


Asn Met His Cys Lys Val Ser Leu Leu Asp Asp Thr Val Tyr Glu Cys 
    210                 215                 220                 


Val Val Glu Lys His Ala Lys Gly Gln Asp Leu Leu Lys Arg Val Cys 
225                 230                 235                 240 


Glu His Leu Asn Leu Leu Glu Glu Asp Tyr Phe Gly Leu Ala Ile Trp 
                245                 250                 255     


Asp Asn Ala Thr Ser Lys Thr Trp Leu Asp Ser Ala Lys Glu Ile Lys 
            260                 265                 270         


Lys Gln Val Arg Gly Val Pro Trp Asn Phe Thr Phe Asn Val Lys Phe 
        275                 280                 285             


Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr 
    290                 295                 300                 


Leu Cys Leu Gln Leu Arg Gln Asp Ile Val Ala Gly Arg Leu Pro Cys 
305                 310                 315                 320 


Ser Phe Ala Thr Leu Ala Leu Leu Gly Ser Tyr Thr Ile Gln Ser Glu 
                325                 330                 335     


Leu Gly Asp Tyr Asp Pro Glu Leu His Gly Val Asp Tyr Val Ser Asp 
            340                 345                 350         


Phe Lys Leu Ala Pro Asn Gln Thr Lys Glu Leu Glu Glu Lys Val Met 
        355                 360                 365             


Glu Leu His Lys Ser Tyr Arg Ser Met Thr Pro Ala Gln Ala Asp Leu 
    370                 375                 380                 


Glu Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu 
385                 390                 395                 400 


His Lys Ala Lys Asp Leu Glu Gly Val Asp Ile Ile Leu Gly Val Cys 
                405                 410                 415     


Ser Ser Gly Leu Leu Val Tyr Lys Asp Lys Leu Arg Ile Asn Arg Phe 
            420                 425                 430         


Pro Trp Pro Lys Val Leu Lys Ile Ser Tyr Lys Arg Ser Ser Phe Phe 
        435                 440                 445             


Ile Lys Ile Arg Pro Gly Glu Gln Glu Gln Tyr Glu Ser Thr Ile Gly 
    450                 455                 460                 


Phe Lys Leu Pro Ser Tyr Arg Ala Ala Lys Lys Leu Trp Lys Val Cys 
465                 470                 475                 480 


Val Glu His His Thr Phe Phe Arg Leu Thr Ser Thr Asp Thr Ile Pro 
                485                 490                 495     


Lys Ser Lys Phe Leu Ala Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg 
            500                 505                 510         


Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala 
        515                 520                 525             


Pro His Phe Glu Arg Thr Ala Ser Lys Arg Ala Ser Arg Ser Leu Asp 
    530                 535                 540                 


Gly Ala Ala Ala Val Asp Ser Ala Asp Arg Ser Pro Arg Pro Thr Ser 
545                 550                 555                 560 


Ala Pro Ala Ile Thr Gln Gly Gln Val Ala Glu Gly Gly Val Leu Asp 
                565                 570                 575     


Ala Ser Ala Lys Lys Thr Val Val Pro Lys Ala Gln Lys Glu Thr Val 
            580                 585                 590         


Lys Ala Glu Val Lys Lys Glu Asp Glu Pro Pro Glu Gln Ala Glu Pro 
        595                 600                 605             


Glu Pro Thr Glu Ala Trp Lys Val Glu Lys Thr His Ile Glu Val Thr 
    610                 615                 620                 


Val Pro Thr Ser Asn Gly Asp Gln Thr Gln Lys Leu Ala Glu Lys Thr 
625                 630                 635                 640 


Glu Asp Leu Ile Arg Met Arg Lys Lys Lys Arg Glu Arg Leu Asp Gly 
                645                 650                 655     


Glu Asn Ile Tyr Ile Arg His Ser Asn Leu Met Leu Glu Asp Leu Asp 
            660                 665                 670         


Lys Ser Gln Glu Glu Ile Lys Lys His His Ala Ser Ile Ser Glu Leu 
        675                 680                 685             


Lys Lys Asn Phe Met Glu Ser Val Pro Glu Pro Arg Pro Ser Glu Trp 
    690                 695                 700                 


Asp Lys Arg Leu Ser Thr His Ser Pro Phe Arg Thr Leu Asn Ile Asn 
705                 710                 715                 720 


Gly Gln Ile Pro Thr Gly Glu Gly Pro Pro Leu Val Lys Thr Gln Thr 
                725                 730                 735     


Val Thr Ile Ser Asp Asn Ala Asn Ala Val Lys Ser Glu Ile Pro Thr 
            740                 745                 750         


Lys Asp Val Pro Ile Val His Thr Glu Thr Lys Thr Ile Thr Tyr Glu 
        755                 760                 765             


Ala Ala Gln Thr Asp Asp Asn Ser Gly Asp Leu Asp Pro Gly Val Leu 
    770                 775                 780                 


Leu Thr Ala Gln Thr Ile Thr Ser Glu Thr Pro Ser Ser Thr Thr Thr 
785                 790                 795                 800 


Thr Gln Ile Thr Lys Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile 
                805                 810                 815     


Glu Lys Arg Ile Val Ile Thr Gly Asp Ala Asp Ile Asp His Asp Gln 
            820                 825                 830         


Val Leu Val Gln Ala Ile Lys Glu Ala Lys Glu Gln His Pro Asp Met 
        835                 840                 845             


Ser Val Thr Lys Val Val Val His Gln Glu Thr Glu Ile Ala Asp Glu 
    850                 855                 860                 


<210> 8
<211> 282
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Leu Lys Gln Ile Ser Ser Asn Lys Cys Phe Gly Gly Leu Gln 
1               5                   10                  15      


Lys Val Phe Glu His Asp Ser Val Glu Leu Asn Cys Lys Met Lys Phe 
            20                  25                  30          


Ala Val Tyr Leu Pro Pro Lys Ala Glu Thr Gly Lys Cys Pro Ala Leu 
        35                  40                  45              


Tyr Trp Leu Ser Gly Leu Thr Cys Thr Glu Gln Asn Phe Ile Ser Lys 
    50                  55                  60                  


Ser Gly Tyr His Gln Ser Ala Ser Glu His Gly Leu Val Val Ile Ala 
65                  70                  75                  80  


Pro Asp Thr Ser Pro Arg Gly Cys Asn Ile Lys Gly Glu Asp Glu Ser 
                85                  90                  95      


Trp Asp Phe Gly Thr Gly Ala Gly Phe Tyr Val Asp Ala Thr Glu Asp 
            100                 105                 110         


Pro Trp Lys Thr Asn Tyr Arg Met Tyr Ser Tyr Val Thr Glu Glu Leu 
        115                 120                 125             


Pro Gln Leu Ile Asn Ala Asn Phe Pro Val Asp Pro Gln Arg Met Ser 
    130                 135                 140                 


Ile Phe Gly His Ser Met Gly Gly His Gly Ala Leu Ile Cys Ala Leu 
145                 150                 155                 160 


Lys Asn Pro Gly Lys Tyr Lys Ser Val Ser Ala Phe Ala Pro Ile Cys 
                165                 170                 175     


Asn Pro Val Leu Cys Pro Trp Gly Lys Lys Ala Phe Ser Gly Tyr Leu 
            180                 185                 190         


Gly Thr Asp Gln Ser Lys Trp Lys Ala Tyr Asp Ala Thr His Leu Val 
        195                 200                 205             


Lys Ser Tyr Pro Gly Ser Gln Leu Asp Ile Leu Ile Asp Gln Gly Lys 
    210                 215                 220                 


Asp Asp Gln Phe Leu Leu Asp Gly Gln Leu Leu Pro Asp Asn Phe Ile 
225                 230                 235                 240 


Ala Ala Cys Thr Glu Lys Lys Ile Pro Val Val Phe Arg Leu Gln Glu 
                245                 250                 255     


Gly Tyr Asp His Ser Tyr Tyr Phe Ile Ala Thr Phe Ile Thr Asp His 
            260                 265                 270         


Ile Arg His His Ala Lys Tyr Leu Asn Ala 
        275                 280         


<210> 9
<211> 147
<212> PRT
<213> Homo sapiens

<400> 9
Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
tcgtcttggc cttttggct                                                    19


<210> 11
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
tccaggtggt ctagcaggtt ct                                                22


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
agggagaaca cggcatcatt                                                   20


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
gacagcacct tcaggagat                                                    19


<210> 14
<211> 109
<212> PRT
<213> Homo sapiens

<400> 14
Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210> 15
<211> 274
<212> PRT
<213> Homo sapiens

<400> 15
Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg 
        


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
tggaacaacc cggtaaagag t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
caccaggggc ataatgagca g                                                 21


<210> 18
<211> 337
<212> PRT
<213> Homo sapiens

<400> 18
Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr Lys Ser Ser Arg Ile Glu 
1               5                   10                  15      


Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro 
            20                  25                  30          


Asn Ile Ser Lys Asp Val Ile Arg Gln Leu Leu Pro Lys Ala Pro Pro 
        35                  40                  45              


Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser 
    50                  55                  60                  


Asp Gly Ser Leu Glu Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile 
65                  70                  75                  80  


Ile Thr Met Pro Thr Glu Ser Asp Phe Leu Met Gln Val Asp Gly Lys 
                85                  90                  95      


Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys 
            100                 105                 110         


Val Val Lys Ala Gln Leu Trp Ile Tyr Leu Arg Pro Val Glu Thr Pro 
        115                 120                 125             


Thr Thr Val Phe Val Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp 
    130                 135                 140                 


Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu Lys Leu Asp Met Asn Pro 
145                 150                 155                 160 


Gly Thr Gly Ile Trp Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn 
                165                 170                 175     


Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu 
            180                 185                 190         


Asp Glu Asn Gly His Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu 
        195                 200                 205             


Asp Gly Leu Asn Pro Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys 
    210                 215                 220                 


Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu 
225                 230                 235                 240 


Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly 
                245                 250                 255     


Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser 
            260                 265                 270         


Gly Glu Cys Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu 
        275                 280                 285             


Val His Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro 
    290                 295                 300                 


Thr Lys Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln 
305                 310                 315                 320 


Ile Ile Tyr Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys 
                325                 330                 335     


Ser 
    


<210> 19
<211> 361
<212> PRT
<213> Mus sp.

<400> 19
Arg Ser Ser Arg Pro Ala Pro Ser Ala Pro Pro Glu Pro Asp Gly Cys 
1               5                   10                  15      


Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser 
            20                  25                  30          


Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn 
        35                  40                  45              


Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu 
    50                  55                  60                  


Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val 
                85                  90                  95      


Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser 
            100                 105                 110         


Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys 
        115                 120                 125             


Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro 
    130                 135                 140                 


Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu 
145                 150                 155                 160 


Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg 
                165                 170                 175     


Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile 
            180                 185                 190         


Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn 
        195                 200                 205             


Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala 
    210                 215                 220                 


Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu 
225                 230                 235                 240 


Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu 
                245                 250                 255     


Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu 
            260                 265                 270         


Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys 
        275                 280                 285             


Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met 
    290                 295                 300                 


Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly 
305                 310                 315                 320 


Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met 
                325                 330                 335     


Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly 
            340                 345                 350         


Met Val Val Asp Arg Cys Gly Cys Ser 
        355                 360     


<210> 20
<211> 147
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Thr Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Ala Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210> 21
<211> 570
<212> PRT
<213> Homo sapiens

<400> 21
Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210> 22
<211> 216
<212> PRT
<213> Homo sapiens

<400> 22
Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210> 23
<211> 192
<212> PRT
<213> Homo sapiens

<400> 23
Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190         


<210> 24
<211> 216
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Ala Gln Gly Glu Pro Gln Val Gln Phe Lys Leu Val Leu Val 
1               5                   10                  15      


Gly Asp Gly Gly Thr Gly Lys Thr Thr Phe Val Lys Arg His Leu Thr 
            20                  25                  30          


Gly Glu Phe Glu Lys Lys Tyr Val Ala Thr Leu Gly Val Glu Val His 
        35                  40                  45              


Pro Leu Val Phe His Thr Asn Arg Gly Pro Ile Lys Phe Asn Val Trp 
    50                  55                  60                  


Asp Thr Ala Gly Gln Glu Lys Phe Gly Gly Leu Arg Asp Gly Tyr Tyr 
65                  70                  75                  80  


Ile Gln Ala Gln Cys Ala Ile Ile Met Phe Asp Val Thr Ser Arg Val 
                85                  90                  95      


Thr Tyr Lys Asn Val Pro Asn Trp His Arg Asp Leu Val Arg Val Cys 
            100                 105                 110         


Glu Asn Ile Pro Ile Val Leu Cys Gly Asn Lys Val Asp Ile Lys Asp 
        115                 120                 125             


Arg Lys Val Lys Ala Lys Ser Ile Val Phe His Arg Lys Lys Asn Leu 
    130                 135                 140                 


Gln Tyr Tyr Asp Ile Ser Ala Lys Ser Asn Tyr Asn Phe Glu Lys Pro 
145                 150                 155                 160 


Phe Leu Trp Leu Ala Arg Lys Leu Ile Gly Asp Pro Asn Leu Glu Phe 
                165                 170                 175     


Val Ala Met Pro Ala Leu Ala Pro Pro Glu Val Val Met Asp Pro Ala 
            180                 185                 190         


Leu Ala Ala Gln Tyr Glu His Asp Leu Glu Val Ala Gln Thr Thr Ala 
        195                 200                 205             


Leu Pro Asp Glu Asp Asp Asp Leu 
    210                 215     


<210> 25
<211> 211
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210> 26
<211> 313
<212> PRT
<213> Homo sapiens

<400> 26
Met Pro Val Ala Gly Ser Glu Leu Pro Arg Arg Pro Leu Pro Pro Ala 
1               5                   10                  15      


Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro Pro His Gly Glu Leu Gln 
            20                  25                  30          


Tyr Leu Gly Gln Ile Gln His Ile Leu Arg Cys Gly Val Arg Lys Asp 
        35                  40                  45              


Asp Arg Thr Gly Thr Gly Thr Leu Ser Val Phe Gly Met Gln Ala Arg 
    50                  55                  60                  


Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu Thr Thr Lys Arg Val Phe 
65                  70                  75                  80  


Trp Lys Gly Val Leu Glu Glu Leu Leu Trp Phe Ile Lys Gly Ser Thr 
                85                  90                  95      


Asn Ala Lys Glu Leu Ser Ser Lys Gly Val Lys Ile Trp Asp Ala Asn 
            100                 105                 110         


Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly Phe Ser Thr Arg Glu Glu 
        115                 120                 125             


Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln Trp Arg His Phe Gly Ala 
    130                 135                 140                 


Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser Gly Gln Gly Val Asp Gln 
145                 150                 155                 160 


Leu Gln Arg Val Ile Asp Thr Ile Lys Thr Asn Pro Asp Asp Arg Arg 
                165                 170                 175     


Ile Ile Met Cys Ala Trp Asn Pro Arg Asp Leu Pro Leu Met Ala Leu 
            180                 185                 190         


Pro Pro Cys His Ala Leu Cys Gln Phe Tyr Val Val Asn Ser Glu Leu 
        195                 200                 205             


Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp Met Gly Leu Gly Val Pro 
    210                 215                 220                 


Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr Tyr Met Ile Ala His Ile 
225                 230                 235                 240 


Thr Gly Leu Lys Pro Gly Asp Phe Ile His Thr Leu Gly Asp Ala His 
                245                 250                 255     


Ile Tyr Leu Asn His Ile Glu Pro Leu Lys Ile Gln Leu Gln Arg Glu 
            260                 265                 270         


Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu Arg Lys Val Glu Lys Ile 
        275                 280                 285             


Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile Glu Gly Tyr Asn Pro His 
    290                 295                 300                 


Pro Thr Ile Lys Met Glu Met Ala Val 
305                 310             


