﻿               SEQUENCE LISTING

<110> ICM (INSTITUT DU CERVEAU ET DE LA MOËLLE ÉPINIÈRE)
      APHP (Assistance Publique - Hôpitaux de Paris)
      Centre National de la Recherche Scientifique (CNRS)
      INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
      (INSERM)
      UPMC (Université Pierre et Marie Curie - Paris 6)
      CORVOL, Jean-Christophe et al

<120> COMPOSITION FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES WITH PARKINSONIAN SYNDROMES

<130> CV - 179/PCT

<160> 4

<170> BiSSAP 1.2

<210> 1
<211> 3651
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3651
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 1
agtattgctg ttcagatagc ctttatttgg gtatatattc tacactgttt ttaaatatgg       60

agagtaacca aaatggccca ttatctgacc acacaaatac tagtagtcat tatagataaa      120

ccatagcaga taaataatag taaacaaagc aacaggctgt gtcattggaa atccccacca      180

tgaagaaagg agcaaggtga aaacttctgg ctgcttcagg tcatgcatgg tccctctcca      240

ccatcgttcc ccctgtcatc ttcctgccag aataaggacc ctggtacctt agggaagcac      300

catctcttgt tttttcccca cgagccctgt gggtcatggc acgtcctgcc ccgctgggaa      360

aacacagtgg gccacgggtt tccctgcagg cctggaccct tcccaagggt agcagcagaa      420

ggcagcacga ttcccactcc tgcagctgtg acagggcacc cccactgtca ctgagccctg      480

caccgggttc catcacctgc tcggggctct gcctttggcc ttttcctgtg aactgcatgt      540

tggccactgt acctatctgt ctctcatctt tttttcttac gggtttgggt atgttcttgg      600

taaaccagcc cttggtctta cacatcattt ccaaggtact aaggactctt caggggaaat      660

acaacttgag cagagtggtt ccctcctctt gtggttcaca aggtgcaggt gcacacacac      720

ataccacagg gcagtgtgac aggaccagag actgcccctg gggtccctgg ctgggggaca      780

ctagtaggga tgtcccttgc ctctctgagg ccttctgctg tctcttctga ggccggaaag      840

gcgaagcact gccctcgccc tgctagggaa ggctcaggcc aggctggccc tatccgggga      900

aggggctcag gtatctggac cttggtcatc gccaggttag ggtttatgtt gatgattatc      960

caaaggcaaa attgatttcc acagaaataa catctgcttt gctgccgagc cagaggagac     1020

cccagacccc tcccgcagcc agagggctgg agcctgctca gaggtgcttt gaaggtgagt     1080

tggccaacgg aagccggggc agtgccaggg tgggacagaa gaggcacaca cctgctctgt     1140

ctacccgagg gcaccagagg gcacgagaag gctggctccc tggcgctgac acgtcaggca     1200

actgaggcac aaggctggca tttctgaacc ttgcccctct gcgaacacaa gggggcgatg     1260

gtggcactcc aagcaaaggg gcgtgtgggt gctgcaggag gagcacagag cactggcgcc     1320

cctcccctcc cgccctgcag atgccggagg ccccgcctct gctgttggca gctgtgttgc     1380

tgggcctggt gctgctggtg gtgctgctgc tgcttctgag gcactggggc tggggcctgt     1440

gccttatcgg ctggaacgag ttcatcctgc agcccatcca caacctgctc atgggtgaca     1500

ccaaggagca gcgcatcctg aaccacgtgc tgcagcatgc ggagcccggg aacgcacaga     1560

gcgtgctgga ggccattgac acctactgcg agcagaagga gtgggccatg aacgtgggcg     1620

acaagaaagg ttggggttcc gggccagcag gtgctcagct ctgggacagg gacccaggac     1680

caggcatcaa atcccgtgcc tggggatcca agttcccctc tctccacctg tgctcacctc     1740

tcctccgtcc ccaaccctgc acaggcaaga tcgtggacgc cgtgattcag gagcaccagc     1800

cctccgtgct gctggagctg ggggcctact gtggctactc agctgtgcgc atggcccgcc     1860

tgctgtcacc aggggcgagg ctcatcacca tcgagatcaa ccccgactgt gccgccatca     1920

cccagcggat ggtggatttc gctggcgtga aggacaaggt gtgcatgcct gacccgttgt     1980

cagacctgga aaaagggccg gctgtgggca gggcgggcat gcgcactttg atcctcccca     2040

ccaggtgttc acaccacgtt cactgaaaac ccactatcac cagggtcatc ccagaaccct     2100

aaagaaaact gatgaatgct tgtatgggtg tgtaaagatg gcctcctgtc tgtgtgggcg     2160

tgggcactga caggcgctgt tgtataggtg tgtagggatg gcctcctgtc tgtgaggacg     2220

tgggcactga caggcgctgt tccaggtcac ccttgtggtt ggagcgtccc aggacatcat     2280

cccccagctg aagaagaagt atgatgtgga cacactggac atggtcttcc tcgaccactg     2340

gaaggaccgg tacctgccgg acacgcttct cttggaggtg agccccaacc aggatggcat     2400

ccgtgccagc tgctgcccag agcccattca gtcagcctca gcctctccaa agagccaggc     2460

attccagtag agccctgtgt ggacacagct cgctctggag gcaccacctg aggtctggga     2520

gtgtggggga ctgaggaggc cctgtggtgg gtggagatgg gtggggagct gggccagggg     2580

ctggctgggt ggcctgttgg gaactgggga gccaagcggt ccctgtcctc acggggccca     2640

tgttctgaag gtggcaccca agtcttgtac agtcctttcc tgcaggagtc acgctgggca     2700

ggaagtggaa acctggcccc aggggctagg cacaggcagt ggtgccgtgg cctagtgagg     2760

agcacccatc ctggtttggg gcaggttctc tgggcacctc tgacctctca cctcccccac     2820

cccccggtct gtttgcagga atgtggcctg ctgcggaagg ggacagtgct actggctgac     2880

aacgtgatct gcccaggtgc gccagacttc ctagcacacg tgcgcgggag cagctgcttt     2940

gagtgcacac actaccaatc gttcctggaa tacagggagg tggtggacgg cctggagaag     3000

gccatctaca agggcccagg cagcgaagca gggccctgac tgcccccccg gcccccctct     3060

cgggctctct cacccagcct ggtactgaag gtgccagacg tgctcctgct gaccttctgc     3120

ggctccgggc tgtgtcctaa atgcaaagca cacctcggcc gaggcctgcg ccctgacatg     3180

ctaacctctc tgaactgcaa cactggattg ttctttttta agactcaatc atgacttctt     3240

tactaacact ggctagctat attatcttat atactaatat catgttttaa aaatataaaa     3300

tagaaattaa gaatctaaat atttagatat aactcgactt agtacatcct tctcaactgc     3360

cattcccctg ctgcccttga cttgggcacc aaacattcaa agctcccctt gacggacgct     3420

aacgctaagg gcggggccct agctggctgg gttctgggtg gcacgcctgg cccactggcc     3480

tcccagccac agtggtgcag aggtcagccc tcctgcagct aggccagggg cacctgttag     3540

ccccatgggg acgactgccg gcctgggaaa cgaagaggag tcagccaagc attcacacct     3600

ttctgaccaa gcaggcgctg gggacaggtg gacccgcagc agcaccagcc c              3651


<210> 2
<211> 221
<212> PRT
<213> Homo sapiens


<400> 2
Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu Gln His 
1               5                   10                  15      
Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp Thr Tyr 
            20                  25                  30          
Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys Gly Lys 
        35                  40                  45              
Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu Leu Glu 
    50                  55                  60                  
Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg Leu Leu 
65                  70                  75                  80  
Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp Cys Ala 
                85                  90                  95      
Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp Lys Val 
            100                 105                 110         
Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu Lys Lys 
        115                 120                 125             
Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His Trp Lys 
    130                 135                 140                 
Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly Leu Leu 
145                 150                 155                 160 
Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro Gly Ala 
                165                 170                 175     
Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu Cys Thr 
            180                 185                 190         
His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly Leu Glu 
        195                 200                 205             
Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
    210                 215                 220     

<210> 3
<211> 271
<212> PRT
<213> Homo sapiens


<400> 3
Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      
Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          
Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              
Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  
Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  
Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      
Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         
Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             
Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 
Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 
Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     
Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         
Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             
Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 
Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 
Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     
Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     

<210> 4
<211> 2304
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2304
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 4
cggcctgcgt ccgccaccgg aagcgccctc ctaatccccg cagcgccacc gccattgccg      60

ccatcgtcgt ggggcttctg gggcagctag ggctgcccgc cgcgctgcct gcgccggacc     120

ggggcgggtc cagtcccggg cgggccgtcg cgggagagaa ataacatctg ctttgctgcc     180

gagctcagag gagaccccag acccctcccg cagccagagg gctggagcct gctcagaggt     240

gctttgaaga tgccggaggc cccgcctctg ctgttggcag ctgtgttgct gggcctggtg     300

ctgctggtgg tgctgctgct gcttctgagg cactggggct ggggcctgtg ccttatcggc     360

tggaacgagt tcatcctgca gcccatccac aacctgctca tgggtgacac caaggagcag     420

cgcatcctga accacgtgct gcagcatgcg gagcccggga acgcacagag cgtgctggag     480

gccattgaca cctactgcga gcagaaggag tgggccatga acgtgggcga caagaaaggc     540

aagatcgtgg acgccgtgat tcaggagcac cagccctccg tgctgctgga gctgggggcc     600

tactgtggct actcagctgt gcgcatggcc cgcctgctgt caccaggggc gaggctcatc     660

accatcgaga tcaaccccga ctgtgccgcc atcacccagc ggatggtgga tttcgctggc     720

gtgaaggaca aggtcaccct tgtggttgga gcgtcccagg acatcatccc ccagctgaag     780

aagaagtatg atgtggacac actggacatg gtcttcctcg accactggaa ggaccggtac     840

ctgccggaca cgcttctctt ggaggaatgt ggcctgctgc ggaaggggac agtgctactg     900

gctgacaacg tgatctgccc aggtgcgcca gacttcctag cacacgtgcg cgggagcagc     960

tgctttgagt gcacacacta ccaatcgttc ctggaataca gggaggtggt ggacggcctg    1020

gagaaggcca tctacaaggg cccaggcagc gaagcagggc cctgactgcc cccccggccc    1080

ccctctcggg ctctctcacc cagcctggta ctgaaggtgc cagacgtgct cctgctgacc    1140

ttctgcggct ccgggctgtg tcctaaatgc aaagcacacc tcggccgagg cctgcgccct    1200

gacatgctaa cctctctgaa ctgcaacact ggattgttct tttttaagac tcaatcatga    1260

cttctttact aacactggct agctatatta tcttatatac taatatcatg ttttaaaaat    1320

ataaaataga aattaagaat ctaaatattt agatataact cgacttagta catccttctc    1380

aactgccatt cccctgctgc ccttgacttg ggcaccaaac attcaaagct ccccttgacg    1440

gacgctaacg ctaagggcgg ggcccctagc tggctgggtt ctgggtggca cgcctggccc    1500

actggcctcc cagccacagt ggtgcagagg tcagccctcc tgcagctagg ccaggggcac    1560

ctgttagccc catggggacg actgccggcc tgggaaacga agaggagtca gccagcattc    1620

acacctttct gaccaagcag gcgctgggga caggtggacc ccgcagcagc accagcccct    1680

ctgggcccca tgtggcacag agtggaagca tctccttccc tactccccac tgggccttgc    1740

ttacagaaga ggcaatggct cagaccagct cccgcatccc tgtagttgcc tccctggccc    1800

atgagtgagg atgcagtgct ggtttctgcc cacctacacc tagagctgtc cccatctcct    1860

ccaaggggtc agactgctag ccacctcaga ggctccaagg gcccagttcc caggcccagg    1920

acaggaatca accctgtgct agctgagttc acctgcaccg agaccagccc ctagccaaga    1980

ttctactcct gggctcaagg cctggctagc ccccagccag cccactccta tggatagaca    2040

gaccagtgag cccaagtgga caagtttggg gccacccagg gaccagaaac agagcctctg    2100

caggacacag cagatgggca cctgggacca cctccaccca gggccctgcc ccagacgcgc    2160

agaggcccga cacaagggag aagccagcca cttgtgccag acctgagtgg cagaaagcaa    2220

aaagttcctt tgctgcttta atttttaaat tttcttacaa aaatttaggt gtttaccaat    2280

agtcttattt tggcttattt ttaa                                           2304


