                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum
 
<120>  B-cell receptor complex binding proteins containing T-cell 
       epitopes

<130>  DK10807PC

<150>  EP 12 160 165.2
<151>  2012-03-19

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  2661
<212>  DNA
<213>  Human herpesvirus 4

<400>  1
atggaggcag ccttgcttgt gtgtcagtac accatccaga gccttatcca actcacgcgt       60

gatgatcctg gttttttcaa tgttgagatt ctggaattcc cattttaccc agcgtgcaat      120

gtttgcacgg cagatgtcaa tgcaactatc aatttcgatg tcgggggcaa aaagcataaa      180

cttaatcttg actttggcct gctgacaccc catacaaagg ctgtctacca acctcgaggt      240

gcatttggtg gctcagaaaa tgccaccaat ctctttctac tggagctcct tggtgcagga      300

gaattggctc taactatgcg gtctaagaag cttccaatta acatcaccac cggagaggag      360

caacaagtaa gcctggaatc tgtagatgtc tactttcaag atgtgtttgg caccatgtgg      420

tgccaccatg cagaaatgca aaacccagta tacctaatac cagaaacagt gccatacata      480

aagtgggata actgtaattc taccaatata acggcagtag taagggcaca ggggctggat      540

gtcacgctac ccttaagttt gccaacatca gctcaagact cgaatttcag cgtaaaaaca      600

gaaatgctcg gtaatgagat agatattgag tgtattatgg aggatggcga aatttcacaa      660

gttctgcccg gagacaacaa atttaacatc acctgcagtg gatacgagag ccatgttccc      720

agcggcggaa ttctcacatc aacgagtccc gtggccaccc caatacctgg tacagggtat      780

gcatacagcc tgcgtctgac accacgtcca gtgtcacgat ttcttggcaa taacagtata      840

ctgtacgtgt tttactctgg gaatggaccg aaggcgagcg ggggagatta ctgcattcag      900

tccaacattg tgttctctga tgagattcca gcttcacagg acatgccgac aaacaccaca      960

gacatcacat atgtgggtga caatgctacc tattcagtgc caatggtcac ttctgaggac     1020

gcaaactcgc caaatgttac agtgactgcc ttttgggcct ggccaaacaa cactgaaact     1080

gactttaagt gcaaatggac tctcacctcg gggacacctt cgggttgtga aaatatttct     1140

ggtgcatttg cgagcaatcg gacatttgac attactgtct cgggtcttgg cacggccccc     1200

aagacactca ttatcacacg aacggctacc aatgccacca caacaaccca caaggttata     1260

ttctccaagg cacccgagag caccaccacc tcccctacct tgaatacaac tggatttgct     1320

gctcccaata caacgacagg tctacccagc tctactcacg tgcctaccaa cctcaccgca     1380

cctgcaagca caggccccac tgtatccacc gcggatgtca ccagcccaac accagccggc     1440

acaacgtcag gcgcatcacc ggtgacacca agtccatctc cacgggacaa cggcacagaa     1500

agtaaggccc ccgacatgac cagccccacc tcagcagtga ctaccccaac cccaaatgcc     1560

accagcccca ccccagcagt gactacccca accccaaatg ccaccagccc caccttggga     1620

aaaacaagtc ccacctcagc agtgactacc ccaaccccaa atgccaccag ccccacccca     1680

gcagtgacta ccccaacccc aaatgccacc atccccacct tgggaaaaac aagtcccacc     1740

tcagcagtga ctaccccaac cccaaatgcc accagcccta ccgtgggaga aacaagtcca     1800

caggcaaata ccaccaacca cacattagga ggaacaagtt ccaccccagt agttaccagc     1860

ccaccaaaaa atgcaaccag tgctgttacc acaggccaac ataacataac ttcaagttca     1920

acctcttcca tgtcactgag acccagttca atctcagaga cactcagccc ctccaccagt     1980

gacaattcaa cgtcacatat gcctttacta acctccgctc acccaacagg tggtgaaaat     2040

ataacacagg tgacaccagc ctctaccagc acacatcatg tgtccaccag ttcgccagcg     2100

ccccgcccag gcaccaccag ccaagcgtca ggccctggaa acagttccac atccacaaaa     2160

ccgggggagg ttaatgtcac caaaggcacg ccccccaaaa atgcaacgtc gccccaggcc     2220

cccagtggcc aaaagacggc ggttcccacg gtcacctcaa caggtggaaa ggccaattct     2280

accaccggtg gaaagcacac cacaggacat ggagcccgga caagtacaga gcccaccaca     2340

gattacggcg gtgattcaac tacgccaaga acgagataca atgcgaccac ctatctacct     2400

cccagcactt ctagcaaact gcggccccgc tggactttta cgagcccacc ggttaccaca     2460

gcccaagcca ccgtgcctgt cccgccaacg tcccagccca gattctcaaa cctctccatg     2520

ctagtactgc agtgggcctc tctggctgtg ctgacccttc tgctgctgct ggtcatggcg     2580

gactgcgcct tcaggcgtaa cttgtcgaca tcccatacct acaccacccc accatatgat     2640

gacgccgaga cctatgtata a                                               2661


<210>  2
<211>  886
<212>  PRT
<213>  Human herpesvirus 4

<400>  2

Met Glu Ala Ala Leu Leu Val Cys Gln Tyr Thr Ile Gln Ser Leu Ile 
1               5                   10                  15      


Gln Leu Thr Arg Asp Asp Pro Gly Phe Phe Asn Val Glu Ile Leu Glu 
            20                  25                  30          


Phe Pro Phe Tyr Pro Ala Cys Asn Val Cys Thr Ala Asp Val Asn Ala 
        35                  40                  45              


Thr Ile Asn Phe Asp Val Gly Gly Lys Lys His Lys Leu Asn Leu Asp 
    50                  55                  60                  


Phe Gly Leu Leu Thr Pro His Thr Lys Ala Val Tyr Gln Pro Arg Gly 
65                  70                  75                  80  


Ala Phe Gly Gly Ser Glu Asn Ala Thr Asn Leu Phe Leu Leu Glu Leu 
                85                  90                  95      


Leu Gly Ala Gly Glu Leu Ala Leu Thr Met Arg Ser Lys Lys Leu Pro 
            100                 105                 110         


Ile Asn Ile Thr Thr Gly Glu Glu Gln Gln Val Ser Leu Glu Ser Val 
        115                 120                 125             


Asp Val Tyr Phe Gln Asp Val Phe Gly Thr Met Trp Cys His His Ala 
    130                 135                 140                 


Glu Met Gln Asn Pro Val Tyr Leu Ile Pro Glu Thr Val Pro Tyr Ile 
145                 150                 155                 160 


Lys Trp Asp Asn Cys Asn Ser Thr Asn Ile Thr Ala Val Val Arg Ala 
                165                 170                 175     


Gln Gly Leu Asp Val Thr Leu Pro Leu Ser Leu Pro Thr Ser Ala Gln 
            180                 185                 190         


Asp Ser Asn Phe Ser Val Lys Thr Glu Met Leu Gly Asn Glu Ile Asp 
        195                 200                 205             


Ile Glu Cys Ile Met Glu Asp Gly Glu Ile Ser Gln Val Leu Pro Gly 
    210                 215                 220                 


Asp Asn Lys Phe Asn Ile Thr Cys Ser Gly Tyr Glu Ser His Val Pro 
225                 230                 235                 240 


Ser Gly Gly Ile Leu Thr Ser Thr Ser Pro Val Ala Thr Pro Ile Pro 
                245                 250                 255     


Gly Thr Gly Tyr Ala Tyr Ser Leu Arg Leu Thr Pro Arg Pro Val Ser 
            260                 265                 270         


Arg Phe Leu Gly Asn Asn Ser Ile Leu Tyr Val Phe Tyr Ser Gly Asn 
        275                 280                 285             


Gly Pro Lys Ala Ser Gly Gly Asp Tyr Cys Ile Gln Ser Asn Ile Val 
    290                 295                 300                 


Phe Ser Asp Glu Ile Pro Ala Ser Gln Asp Met Pro Thr Asn Thr Thr 
305                 310                 315                 320 


Asp Ile Thr Tyr Val Gly Asp Asn Ala Thr Tyr Ser Val Pro Met Val 
                325                 330                 335     


Thr Ser Glu Asp Ala Asn Ser Pro Asn Val Thr Val Thr Ala Phe Trp 
            340                 345                 350         


Ala Trp Pro Asn Asn Thr Glu Thr Asp Phe Lys Cys Lys Trp Thr Leu 
        355                 360                 365             


Thr Ser Gly Thr Pro Ser Gly Cys Glu Asn Ile Ser Gly Ala Phe Ala 
    370                 375                 380                 


Ser Asn Arg Thr Phe Asp Ile Thr Val Ser Gly Leu Gly Thr Ala Pro 
385                 390                 395                 400 


Lys Thr Leu Ile Ile Thr Arg Thr Ala Thr Asn Ala Thr Thr Thr Thr 
                405                 410                 415     


His Lys Val Ile Phe Ser Lys Ala Pro Glu Ser Thr Thr Thr Ser Pro 
            420                 425                 430         


Thr Leu Asn Thr Thr Gly Phe Ala Ala Pro Asn Thr Thr Thr Gly Leu 
        435                 440                 445             


Pro Ser Ser Thr His Val Pro Thr Asn Leu Thr Ala Pro Ala Ser Thr 
    450                 455                 460                 


Gly Pro Thr Val Ser Thr Ala Asp Val Thr Ser Pro Thr Pro Ala Gly 
465                 470                 475                 480 


Thr Thr Ser Gly Ala Ser Pro Val Thr Pro Ser Pro Ser Pro Arg Asp 
                485                 490                 495     


Asn Gly Thr Glu Ser Lys Ala Pro Asp Met Thr Ser Pro Thr Ser Ala 
            500                 505                 510         


Val Thr Thr Pro Thr Pro Asn Ala Thr Ser Pro Thr Pro Ala Val Thr 
        515                 520                 525             


Thr Pro Thr Pro Asn Ala Thr Ser Pro Thr Leu Gly Lys Thr Ser Pro 
    530                 535                 540                 


Thr Ser Ala Val Thr Thr Pro Thr Pro Asn Ala Thr Ser Pro Thr Pro 
545                 550                 555                 560 


Ala Val Thr Thr Pro Thr Pro Asn Ala Thr Ile Pro Thr Leu Gly Lys 
                565                 570                 575     


Thr Ser Pro Thr Ser Ala Val Thr Thr Pro Thr Pro Asn Ala Thr Ser 
            580                 585                 590         


Pro Thr Val Gly Glu Thr Ser Pro Gln Ala Asn Thr Thr Asn His Thr 
        595                 600                 605             


Leu Gly Gly Thr Ser Ser Thr Pro Val Val Thr Ser Pro Pro Lys Asn 
    610                 615                 620                 


Ala Thr Ser Ala Val Thr Thr Gly Gln His Asn Ile Thr Ser Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Met Ser Leu Arg Pro Ser Ser Ile Ser Glu Thr Leu Ser 
                645                 650                 655     


Pro Ser Thr Ser Asp Asn Ser Thr Ser His Met Pro Leu Leu Thr Ser 
            660                 665                 670         


Ala His Pro Thr Gly Gly Glu Asn Ile Thr Gln Val Thr Pro Ala Ser 
        675                 680                 685             


Thr Ser Thr His His Val Ser Thr Ser Ser Pro Ala Pro Arg Pro Gly 
    690                 695                 700                 


Thr Thr Ser Gln Ala Ser Gly Pro Gly Asn Ser Ser Thr Ser Thr Lys 
705                 710                 715                 720 


Pro Gly Glu Val Asn Val Thr Lys Gly Thr Pro Pro Lys Asn Ala Thr 
                725                 730                 735     


Ser Pro Gln Ala Pro Ser Gly Gln Lys Thr Ala Val Pro Thr Val Thr 
            740                 745                 750         


Ser Thr Gly Gly Lys Ala Asn Ser Thr Thr Gly Gly Lys His Thr Thr 
        755                 760                 765             


Gly His Gly Ala Arg Thr Ser Thr Glu Pro Thr Thr Asp Tyr Gly Gly 
    770                 775                 780                 


Asp Ser Thr Thr Pro Arg Thr Arg Tyr Asn Ala Thr Thr Tyr Leu Pro 
785                 790                 795                 800 


Pro Ser Thr Ser Ser Lys Leu Arg Pro Arg Trp Thr Phe Thr Ser Pro 
                805                 810                 815     


Pro Val Thr Thr Ala Gln Ala Thr Val Pro Val Pro Pro Thr Ser Gln 
            820                 825                 830         


Pro Arg Phe Ser Asn Leu Ser Met Leu Val Leu Gln Trp Ala Ser Leu 
        835                 840                 845             


Ala Val Leu Thr Leu Leu Leu Leu Leu Val Met Ala Asp Cys Ala Phe 
    850                 855                 860                 


Arg Arg Asn Leu Ser Thr Ser His Thr Tyr Thr Thr Pro Pro Tyr Asp 
865                 870                 875                 880 


Asp Ala Glu Thr Tyr Val 
                885     


<210>  3
<211>  4184
<212>  DNA
<213>  Homo sapiens

<400>  3
atttaagggc ccgcctctcc tggctcacag ctgcttgctg ctccagcctt gccctcccag       60

agctgccgga cgctcgcggg tctcggaacg catcccgccg cgggggcttc ggccgtggca      120

tgggcgccgc gggcctgctc ggggttttct tggctctcgt cgcaccgggg gtcctcggga      180

tttcttgtgg ctctcctccg cctatcctaa atggccggat tagttattat tctaccccca      240

ttgctgttgg taccgtgata aggtacagtt gttcaggtac cttccgcctc attggagaaa      300

aaagtctatt atgcataact aaagacaaag tggatggaac ctgggataaa cctgctccta      360

aatgtgaata tttcaataaa tattcttctt gccctgagcc catagtacca ggaggataca      420

aaattagagg ctctacaccc tacagacatg gtgattctgt gacatttgcc tgtaaaacca      480

acttctccat gaacggaaac aagtctgttt ggtgtcaagc aaataatatg tgggggccga      540

cacgactacc aacctgtgta agtgttttcc ctctcgagtg tccagcactt cctatgatcc      600

acaatggaca tcacacaagt gagaatgttg gctccattgc tccaggattg tctgtgactt      660

acagctgtga atctggttac ttgcttgttg gagaaaagat cattaactgt ttgtcttcgg      720

gaaaatggag tgctgtcccc cccacatgtg aagaggcacg ctgtaaatct ctaggacgat      780

ttcccaatgg gaaggtaaag gagcctccaa ttctccgggt tggtgtaact gcaaactttt      840

tctgtgatga agggtatcga ctgcaaggcc caccttctag tcggtgtgta attgctggac      900

agggagttgc ttggaccaaa atgccagtat gtgaagaaat tttttgccca tcacctcccc      960

ctattctcaa tggaagacat ataggcaact cactagcaaa tgtctcatat ggaagcatag     1020

tcacttacac ttgtgacccg gacccagagg aaggagtgaa cttcatcctt attggagaga     1080

gcactctccg ttgtacagtt gatagtcaga agactgggac ctggagtggc cctgccccac     1140

gctgtgaact ttctacttct gcggttcagt gtccacatcc ccagatccta agaggccgaa     1200

tggtatctgg gcagaaagat cgatatacct ataacgacac tgtgatattt gcttgcatgt     1260

ttggcttcac cttgaagggc agcaagcaaa tccgatgcaa tgcccaaggc acatgggagc     1320

catctgcacc agtctgtgaa aaggaatgcc aggcccctcc taacatcctc aatgggcaaa     1380

aggaagatag acacatggtc cgctttgacc ctggaacatc tataaaatat agctgtaacc     1440

ctggctatgt gctggtggga gaagaatcca tacagtgtac ctctgagggg gtgtggacac     1500

cccctgtacc ccaatgcaaa gtggcagcgt gtgaagctac aggaaggcaa ctcttgacaa     1560

aaccccagca ccaatttgtt agaccagatg tcaactcttc ttgtggtgaa gggtacaagt     1620

taagtgggag tgtttatcag gagtgtcaag gcacaattcc ttggtttatg gagattcgtc     1680

tttgtaaaga aatcacctgc ccaccacccc ctgttatcta caatggggca cacaccggga     1740

gttccttaga agattttcca tatggaacca cggtcactta cacatgtaac cctgggccag     1800

aaagaggagt ggaattcagc ctcattggag agagcaccat ccgttgtaca agcaatgatc     1860

aagaaagagg cacctggagt ggccctgctc ccctgtgtaa actttccctc cttgctgtcc     1920

agtgctcaca tgtccatatt gcaaatggat acaagatatc tggcaaggaa gccccatatt     1980

tctacaatga cactgtgaca ttcaagtgtt atagtggatt tactttgaag ggcagtagtc     2040

agattcgttg caaagctgat aacacctggg atcctgaaat accagtttgt gaaaaaggct     2100

gccagtcacc tcctgggctc caccatggtc gtcatacagg tggaaatacg gtcttctttg     2160

tctctgggat gactgtagac tacacttgtg accctggcta tttgcttgtg ggaaacaaat     2220

ccattcactg tatgccttca ggaaattgga gtccttctgc cccacggtgt gaagaaacat     2280

gccagcatgt gagacagagt cttcaagaac ttccagctgg ttcacgtgtg gagctagtta     2340

atacgtcctg ccaagatggg taccagttga ctggacatgc ttatcagatg tgtcaagatg     2400

ctgaaaatgg aatttggttc aaaaagattc cactttgtaa agttattcac tgtcaccctc     2460

caccagtgat tgtcaatggg aagcacacag gcatgatggc agaaaacttt ctatatggaa     2520

atgaagtctc ttatgaatgt gaccaaggat tctatctcct gggagagaaa aaattgcagt     2580

gcagaagtga ttctaaagga catggatctt ggagcgggcc ttccccacag tgcttacgat     2640

ctcctcctgt gactcgctgc cctaatccag aagtcaaaca tgggtacaag ctcaataaaa     2700

cacattctgc atattcccac aatgacatag tgtatgttga ctgcaatcct ggcttcatca     2760

tgaatggtag tcgcgtgatt aggtgtcata ctgataacac atgggtgcca ggtgtgccaa     2820

cttgtatcaa aaaagccttc atagggtgtc cacctccgcc taagacccct aacgggaacc     2880

atactggtgg aaacatagct cgattttctc ctggaatgtc aatcctgtac agctgtgacc     2940

aaggctacct gctggtggga gaggcactcc ttctttgcac acatgaggga acctggagcc     3000

aacctgcccc tcattgtaaa gaggtaaact gtagctcacc agcagatatg gatggaatcc     3060

agaaagggct ggaaccaagg aaaatgtatc agtatggagc tgttgtaact ctggagtgtg     3120

aagatgggta tatgctggaa ggcagtcccc agagccagtg ccaatcggat caccaatgga     3180

accctcccct ggcggtttgc agatcccgtt cacttgctcc tgtcctttgt ggtattgctg     3240

caggtttgat acttcttacc ttcttgattg tcattacctt atacgtgata tcaaaacaca     3300

gagcacgcaa ttattataca gatacaagcc agaaagaagc ttttcattta gaagcacgag     3360

aagtatattc tgttgatcca tacaacccag ccagctgatc agaagacaaa ctggtgtgtg     3420

cctcattgct tggaattcag cggaatattg attagaaaga aactgctcta atatcagcaa     3480

gtctctttat atggcctcaa gatcaatgaa atgatgtcat aagcgatcac ttcctatatg     3540

cacttattct caagaagaac atctttatgg taaagatggg agcccagttt cactgccata     3600

tactcttcaa ggactttctg aagcctcact tatgagatgc ctgaagccag gccatggcta     3660

taaacaatta catggctcta aaaagttttg ccctttttaa ggaaggcact aaaaagagct     3720

gtcctggtat ctagacccat cttctttttg aaatcagcat actcaatgtt actatctgct     3780

tttggttata atgtgttttt aattatctaa agtatgaagc attttctggg gttatgatgg     3840

ctttaccttt attaggaagt atggttttat tttgatagta gcttcctcct ctggtggtgt     3900

taatcatttc atttttaccc ttacttggtt tgagtttctc tcacattact gtatatactt     3960

tgcctttcca taatcactca gtgattgcaa tttgcacaag tttttttaaa ttatgggaat     4020

caagatttaa tcctagagat ttggtgtaca attcaggctt tggatgtttc tttagcagtt     4080

ttgtgataag ttctagttgc ttgtaaaatt tcacttaata atgtgtacat tagtcattca     4140

ataaattgta attgtaaaga aaacatacaa aaaaaaaaaa aaaa                      4184


<210>  4
<211>  1092
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Ser Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr 
        675                 680                 685             


Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser 
            820                 825                 830         


Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val Thr Arg Cys Pro 
        835                 840                 845             


Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala 
    850                 855                 860                 


Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile 
865                 870                 875                 880 


Met Asn Gly Ser Arg Val Ile Arg Cys His Thr Asp Asn Thr Trp Val 
                885                 890                 895     


Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro 
            900                 905                 910         


Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg 
        915                 920                 925             


Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu 
    930                 935                 940                 


Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser 
945                 950                 955                 960 


Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp 
                965                 970                 975     


Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr 
            980                 985                 990         


Gly Ala Val Val Thr Leu Glu Cys  Glu Asp Gly Tyr Met  Leu Glu Gly 
        995                 1000                 1005             


Ser Pro  Gln Ser Gln Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro 
    1010                 1015                 1020             


Leu Ala  Val Cys Arg Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly 
    1025                 1030                 1035             


Ile Ala  Ala Gly Leu Ile Leu  Leu Thr Phe Leu Ile  Val Ile Thr 
    1040                 1045                 1050             


Leu Tyr  Val Ile Ser Lys His  Arg Ala Arg Asn Tyr  Tyr Thr Asp 
    1055                 1060                 1065             


Thr Ser  Gln Lys Glu Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr 
    1070                 1075                 1080             


Ser Val  Asp Pro Tyr Asn Pro  Ala Ser 
    1085                 1090         


<210>  5
<211>  4007
<212>  DNA
<213>  Homo sapiens

<400>  5
atttaagggc ccgcctctcc tggctcacag ctgcttgctg ctccagcctt gccctcccag       60

agctgccgga cgctcgcggg tctcggaacg catcccgccg cgggggcttc ggccgtggca      120

tgggcgccgc gggcctgctc ggggttttct tggctctcgt cgcaccgggg gtcctcggga      180

tttcttgtgg ctctcctccg cctatcctaa atggccggat tagttattat tctaccccca      240

ttgctgttgg taccgtgata aggtacagtt gttcaggtac cttccgcctc attggagaaa      300

aaagtctatt atgcataact aaagacaaag tggatggaac ctgggataaa cctgctccta      360

aatgtgaata tttcaataaa tattcttctt gccctgagcc catagtacca ggaggataca      420

aaattagagg ctctacaccc tacagacatg gtgattctgt gacatttgcc tgtaaaacca      480

acttctccat gaacggaaac aagtctgttt ggtgtcaagc aaataatatg tgggggccga      540

cacgactacc aacctgtgta agtgttttcc ctctcgagtg tccagcactt cctatgatcc      600

acaatggaca tcacacaagt gagaatgttg gctccattgc tccaggattg tctgtgactt      660

acagctgtga atctggttac ttgcttgttg gagaaaagat cattaactgt ttgtcttcgg      720

gaaaatggag tgctgtcccc cccacatgtg aagaggcacg ctgtaaatct ctaggacgat      780

ttcccaatgg gaaggtaaag gagcctccaa ttctccgggt tggtgtaact gcaaactttt      840

tctgtgatga agggtatcga ctgcaaggcc caccttctag tcggtgtgta attgctggac      900

agggagttgc ttggaccaaa atgccagtat gtgaagaaat tttttgccca tcacctcccc      960

ctattctcaa tggaagacat ataggcaact cactagcaaa tgtctcatat ggaagcatag     1020

tcacttacac ttgtgacccg gacccagagg aaggagtgaa cttcatcctt attggagaga     1080

gcactctccg ttgtacagtt gatagtcaga agactgggac ctggagtggc cctgccccac     1140

gctgtgaact ttctacttct gcggttcagt gtccacatcc ccagatccta agaggccgaa     1200

tggtatctgg gcagaaagat cgatatacct ataacgacac tgtgatattt gcttgcatgt     1260

ttggcttcac cttgaagggc agcaagcaaa tccgatgcaa tgcccaaggc acatgggagc     1320

catctgcacc agtctgtgaa aaggaatgcc aggcccctcc taacatcctc aatgggcaaa     1380

aggaagatag acacatggtc cgctttgacc ctggaacatc tataaaatat agctgtaacc     1440

ctggctatgt gctggtggga gaagaatcca tacagtgtac ctctgagggg gtgtggacac     1500

cccctgtacc ccaatgcaaa gtggcagcgt gtgaagctac aggaaggcaa ctcttgacaa     1560

aaccccagca ccaatttgtt agaccagatg tcaactcttc ttgtggtgaa gggtacaagt     1620

taagtgggag tgtttatcag gagtgtcaag gcacaattcc ttggtttatg gagattcgtc     1680

tttgtaaaga aatcacctgc ccaccacccc ctgttatcta caatggggca cacaccggga     1740

gttccttaga agattttcca tatggaacca cggtcactta cacatgtaac cctgggccag     1800

aaagaggagt ggaattcagc ctcattggag agagcaccat ccgttgtaca agcaatgatc     1860

aagaaagagg cacctggagt ggccctgctc ccctgtgtaa actttccctc cttgctgtcc     1920

agtgctcaca tgtccatatt gcaaatggat acaagatatc tggcaaggaa gccccatatt     1980

tctacaatga cactgtgaca ttcaagtgtt atagtggatt tactttgaag ggcagtagtc     2040

agattcgttg caaagctgat aacacctggg atcctgaaat accagtttgt gaaaaagaaa     2100

catgccagca tgtgagacag agtcttcaag aacttccagc tggttcacgt gtggagctag     2160

ttaatacgtc ctgccaagat gggtaccagt tgactggaca tgcttatcag atgtgtcaag     2220

atgctgaaaa tggaatttgg ttcaaaaaga ttccactttg taaagttatt cactgtcacc     2280

ctccaccagt gattgtcaat gggaagcaca caggcatgat ggcagaaaac tttctatatg     2340

gaaatgaagt ctcttatgaa tgtgaccaag gattctatct cctgggagag aaaaaattgc     2400

agtgcagaag tgattctaaa ggacatggat cttggagcgg gccttcccca cagtgcttac     2460

gatctcctcc tgtgactcgc tgccctaatc cagaagtcaa acatgggtac aagctcaata     2520

aaacacattc tgcatattcc cacaatgaca tagtgtatgt tgactgcaat cctggcttca     2580

tcatgaatgg tagtcgcgtg attaggtgtc atactgataa cacatgggtg ccaggtgtgc     2640

caacttgtat caaaaaagcc ttcatagggt gtccacctcc gcctaagacc cctaacggga     2700

accatactgg tggaaacata gctcgatttt ctcctggaat gtcaatcctg tacagctgtg     2760

accaaggcta cctgctggtg ggagaggcac tccttctttg cacacatgag ggaacctgga     2820

gccaacctgc ccctcattgt aaagaggtaa actgtagctc accagcagat atggatggaa     2880

tccagaaagg gctggaacca aggaaaatgt atcagtatgg agctgttgta actctggagt     2940

gtgaagatgg gtatatgctg gaaggcagtc cccagagcca gtgccaatcg gatcaccaat     3000

ggaaccctcc cctggcggtt tgcagatccc gttcacttgc tcctgtcctt tgtggtattg     3060

ctgcaggttt gatacttctt accttcttga ttgtcattac cttatacgtg atatcaaaac     3120

acagagcacg caattattat acagatacaa gccagaaaga agcttttcat ttagaagcac     3180

gagaagtata ttctgttgat ccatacaacc cagccagctg atcagaagac aaactggtgt     3240

gtgcctcatt gcttggaatt cagcggaata ttgattagaa agaaactgct ctaatatcag     3300

caagtctctt tatatggcct caagatcaat gaaatgatgt cataagcgat cacttcctat     3360

atgcacttat tctcaagaag aacatcttta tggtaaagat gggagcccag tttcactgcc     3420

atatactctt caaggacttt ctgaagcctc acttatgaga tgcctgaagc caggccatgg     3480

ctataaacaa ttacatggct ctaaaaagtt ttgccctttt taaggaaggc actaaaaaga     3540

gctgtcctgg tatctagacc catcttcttt ttgaaatcag catactcaat gttactatct     3600

gcttttggtt ataatgtgtt tttaattatc taaagtatga agcattttct ggggttatga     3660

tggctttacc tttattagga agtatggttt tattttgata gtagcttcct cctctggtgg     3720

tgttaatcat ttcattttta cccttacttg gtttgagttt ctctcacatt actgtatata     3780

ctttgccttt ccataatcac tcagtgattg caatttgcac aagttttttt aaattatggg     3840

aatcaagatt taatcctaga gatttggtgt acaattcagg ctttggatgt ttctttagca     3900

gttttgtgat aagttctagt tgcttgtaaa atttcactta ataatgtgta cattagtcat     3960

tcaataaatt gtaattgtaa agaaaacata caaaaaaaaa aaaaaaa                   4007


<210>  6
<211>  1033
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Thr Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Thr Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Thr Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Gly Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe 
            740                 745                 750         


Tyr Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly 
        755                 760                 765             


His Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro 
    770                 775                 780                 


Val Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn 
785                 790                 795                 800 


Lys Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys 
                805                 810                 815     


Asn Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Thr 
            820                 825                 830         


Asp Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe 
        835                 840                 845             


Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly 
    850                 855                 860                 


Gly Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys 
865                 870                 875                 880 


Asp Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His 
                885                 890                 895     


Glu Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys 
            900                 905                 910         


Ser Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg 
        915                 920                 925             


Lys Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly 
    930                 935                 940                 


Tyr Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln 
945                 950                 955                 960 


Trp Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val 
                965                 970                 975     


Leu Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val 
            980                 985                 990         


Ile Thr Leu Tyr Val Ile Ser Lys  His Arg Ala Arg Asn  Tyr Tyr Thr 
        995                 1000                 1005             


Asp Thr  Ser Gln Lys Glu Ala  Phe His Leu Glu Ala  Arg Glu Val 
    1010                 1015                 1020             


Tyr Ser  Val Asp Pro Tyr Asn  Pro Ala Ser 
    1025                 1030             


<210>  7
<211>  7409
<212>  DNA
<213>  Homo sapiens

<400>  7
aggcccctgc ctgccccagc atcccctgcg cgaagctggg tgccccggag agtctgacca       60

ccatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg gaagtcaggc      120

ccgaggaacc tctagtggtg aaggtggaag gtatgtccaa agggcagaaa gggaagggat      180

tgaggctgga aacttgagtt gtggctgggt gtccttggct gagtaactta ccctctctga      240

gcctccattt tcttatttgt aaaattcagg aaagggttgg aaggactctg ccggctcctc      300

cactcccagc ttttggagtc ctctgctcta taacctggtg tgaggagtcg gggggcttgg      360

aggtcccccc cacccatgcc cacacctctc tccctctctc tccacagagg gagataacgc      420

tgtgctgcag tgcctcaagg ggacctcaga tggccccact cagcagctga cctggtctcg      480

ggagtccccg cttaaaccct tcttaaaact cagcctgggg ctgccaggcc tgggaatcca      540

catgaggccc ctggccatct ggcttttcat cttcaacgtc tctcaacaga tggggggctt      600

ctacctgtgc cagccggggc ccccctctga gaaggcctgg cagcctggct ggacagtcaa      660

tgtggagggc agcggtgagg gccgggctgg ggcaggggca ggaggagaga agggaggcca      720

ccatggacag aagaggtccg cggccacaat ggagctggag agaggggctg gagggattga      780

gggcgaaact cggagctagg tgggcagact cctggggctt cgtggcttca gtatgagctg      840

cttcctgtcc ctctacctct cactgtcttc tctctctctg cgggtctttg tctctattta      900

tctctgtctt tgagtctcta tctctctccc tctcctgggt gtctctgcat ttggttctgg      960

gtctcttccc aggggagctg ttccggtgga atgtttcgga cctaggtggc ctgggctgtg     1020

gcctgaagaa caggtcctca gagggcccca gctccccttc cgggaagctc atgagcccca     1080

agctgtatgt gtgggccaaa gaccgccctg agatctggga gggagagcct ccgtgtctcc     1140

caccgaggga cagcctgaac cagagcctca gccagggtat ggtgatgact ggggagatgc     1200

cgggaagcgg gggtccagag acagagggga ggggaaactg aagaggtgaa accctgagga     1260

tcaggctttc cttgtcttat ctctccctgt cccagacctc accatggccc ctggctccac     1320

actctggctg tcctgtgggg taccccctga ctctgtgtcc aggggccccc tctcctggac     1380

ccatgtgcac cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc     1440

ggccagagat atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga     1500

cgctggaaag tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac     1560

tgctcggcca ggtagagttt ctctcaactg ggaggcatct gtgtgggggt actgggaaga     1620

agtggaagcc agtcaatctt agattccccc aacccgaggg ctactcccag cctcacccca     1680

aaccccaact tccacacaga acactgactc caagtctttc ttttttttga cagagtctcg     1740

ctctgttgcc taggctggag tgcagtggtg ccatcttgtc ttggctcact gcaacctccg     1800

cctcccaggt tcaagtgatt cccctgcctc agcctcctga gtagctggga ttacaggtgc     1860

ccaccaccac gcctggctaa tttttttttt ttttttgaga cggagtcttg cactgtcacc     1920

caggctggag tgcagtggca cgatctcagc tcactgcaac ctccaccttc caggttcaag     1980

tgattctcct gcctcagcct cccgagtagc tgggattaaa gcctggctaa ttttttttgt     2040

atttttagta gagatggggt ttcattatgt tggccaggct ggtctcaaac tcctgacctc     2100

gtgatccacc cgcctcggcc tcccaaagtg ctgggattac agacatgagc cacagggccg     2160

ggccaagcct aattttgtat ttttagtaga gatggggttt ctccctgttg gaccaggctg     2220

gtcttgaact cctgacttca ggtgatctgc ctgccttggc ctcccaaagt actgggatta     2280

caggcataag ccaccgcacc tggcctagac ttcaagtctt tcttccctcg cttccaagac     2340

actacttttc tgggtcttca cctaccattg cttgcgcctg cccaccagct tgggtggagt     2400

cttccttcct ccccaactcc tcactcttgg agccctgggc cctcttctta tccctgtctg     2460

cacactttcc tatttgaact tgactctcaa tggcttcttg ggtcaccatg ccttggtgac     2520

tctattccag gctccatact cagccatctc ctgtgccatt tgatatccca tggacacctc     2580

aggctcaaca gatacaaaat caaactcaat gtcttcccca agtatagtct tcttggtggc     2640

ccagtgtaag cagagggcac caccacctgc tccctcgccc aggctaagaa cctgggcatc     2700

cttctttttc ctcaccccgt ccaacaaact ggtcacagtg ttctgccaat tctctctcca     2760

tgcaatccta tcatgctatc ctaactgcaa ttcacaaacc caaccccaac tttcactcca     2820

aacttgatcc aagcaatgtg ctggatccca actgtaacct tgcaaactca actctgccct     2880

tcactttgac cgtgactatc cttaattgca gcaggaaact gatcattatg ctcccctcaa     2940

tccacacatt gcctctgagt acagccatgg tttgtccacg atttgctcaa agacactgcc     3000

ccatgtcctg tgccagggtc tgtgacaatc cctgacctcc tgggacatgg ctccttagag     3060

agaggagagc ctttctcaca gcttgggact ttgagtctgt gtcttttttt ttttcttgag     3120

acggagtttt gctgtggttg cccaggctgg agtgcagtga tctcggctca ctgaaacctc     3180

cgcctcccgg gttcaaacga ttctcctgcc tcagcctccc aagtagctgg gattacaggc     3240

acccaccacc atgcccagct aatttttttg tatttttagt agagatgggg tttcaccatg     3300

ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acccgccttt gcctcccaaa     3360

gtgctgggat tacaggcgtc aaccaccgcg cccggccgag tctgtgtctt gcctctgtgc     3420

ctcagacttg cggttccttg agatctcagg attgggacgt aagatgccag cctggggtcc     3480

tcgtctcata gccccttccc cctagtacta tggcactggc tgctgaggac tggtggctgg     3540

aaggtctcag ctgtgacttt ggcttatctg atcttctgcc tgtgttccct tgtgggcatt     3600

cttcatcttc aaagaggtga gtcatgtccc cagtgggtct gtccaaaccc tactccatct     3660

tccccaggat aagccggctc tggccagtct gacaaccatc tttctttcct cccatccctc     3720

ccttcaagac cccagaatcc tgttctcccc agtcttcctc tagcctccct caaacttccc     3780

aagcctcttg caattttttt tttttttttg agacagggtc tcattctgtc accccagctg     3840

gagtgcagtg gcacaatctg agctcactgt aacctctgcc tcccaggctt aagtgattct     3900

tgtgcttcag cctcccgagt acctgggact acaagtgtat gccaccacac ccggccaatt     3960

ttttatattt ttagtagaga cgaggtttca ccatgttggc cagactggtc tcgaactctt     4020

gacctcaaat gatccgccca cctcggcctc ccaaagtgct gggattacag gcacgagcca     4080

ccgcgcccgt ccgcctcgca atttgaactc ctgtctcctt tgttgaacca agtgacctcc     4140

ccagcacctg gccccacaaa tcctcaccct gccaagcagc ccctcctctg atcacgccct     4200

ttaactccca ccagccctgg tcctgaggag gaaaagaaag cgaatgactg accccaccag     4260

gaggtaatgc aaccagtgca ccccgcggta acaccctcca ccttcacttt atgccttgca     4320

cttactgttt cctctgccca ggggttcttt gctccgtctc tactgtttca aatactgccc     4380

aacctcaaag cccagctcca aagctacctc ctctgtgaag aactccttgg aaatgatcat     4440

ctcagactcc tctattggct gtcccagcac aagtgatcac gtttaacttc tgaaggcctg     4500

gacagaatct tgagtgggtc cgccattcca ttccaagtcg gccctcaccg tgcacttcct     4560

cttctcccgc cagattcttc aaagtgacgc ctcccccagg aagcgggccc cagaaccagt     4620

acgggaacgt gctgtctctc cccacaccca cctcaggcct cggtaagagg caccgcccct     4680

ccagcctata gctccgcccc agatccgggg ctccaccccc actctcctca tccctccaat     4740

ccgctgtgcg ccaagccttc tggagctcgg aactccgccc ccggggcggg gagtcccgcc     4800

cagctatgag ccccgcctct agaaccagac cccgcctcca gggctcagag ccacgccccc     4860

aggacccaga gcctgaagtc gtaatcaaga gcagaacttc gccccagaac tgaaggcctc     4920

ggccctagat ttagattccg ccccagggtt caaggccggg ttcctagacc cagagtccat     4980

tcgcagagcc caaaacatcc tcttcccgtg ccccgccgcg cggaccctta gccttgaccg     5040

cccccatctc ttctgacccc gtcttacaat gcccctctca ccaggacgcg cccagcgttg     5100

ggccgcaggc ctggggggca ctgccccgtc ttatggaaac ccgagcagcg acgtccaggc     5160

ggatggagcc ttggggtccc ggagcccgcc gggagtgggt gaatgactgg gagagggaag     5220

ggtcgttccc cacatggagg gggttggagc ggtctgtggc ccgaatagtg gactgggccc     5280

tggaggagag ggggcatgac tcggttcccc atccccatcc ccaaaccccc aggcccagaa     5340

gaagaggaag gggagggcta tgaggaacct gacagtgagg aggactccga gttctatgag     5400

aacgactcca accttgggca ggaccagctc tcccagggta aggctgccct cccccgtggc     5460

cccccacctc tgcggtggcc tgtggactcc catggacacc cctccttctc caccagatgg     5520

cagcggctac gagaaccctg aggatgagcc cctgggtcct gaggatgaag actccttctc     5580

caacggtaac ttggggcctt tgtgggacct cagagactta ggtgtaattg cagcgctgtg     5640

acactcctag aaggggtccc tggagttctc tctcttctgc cacagctgag tcttatgaga     5700

acgaggatga agagctgacc cagccggtcg ccaggacaat gggtgtgtgt gaggatggca     5760

acagtccagg ggggaggcgg aggacacctg gaggccagga ggaatagtaa cctccctctt     5820

ccctttccag acttcctgag ccctcatggg tcagcctggg accccagccg ggaagcaacc     5880

tccctgggtg agagatgctt tcaatcagac tgccttgccc agcttgggtg acctggcctc     5940

agctctgaca ccagatccaa ctttgacctg accctgaccc caaacccgaa cccaatcctg     6000

tgactcctct cacctcaaca ctgagcccca tcccccatcc tgagccccat cccccatcct     6060

gacccccaat atttaccccc tccctaactg tgaatatcaa caccgatccc aatgcagtat     6120

cagcctggac ttgatctcca cctcacctca gccccagtgc agacctcaac ttggacccca     6180

gcttactctg cagcttcttc atgactctga ctccgactcc ctccagtttc ttctttttct     6240

ttttcttttt tttgagacgg agtctccctc tgttgcccag gctggagtgc agttgccacc     6300

tctgcctcct aggttcaagc gattctcatg cctcagcctc ctgagtagct gggattatag     6360

acgtttgcca ccacacctgg ctaatttttg tattttcagt agagacaggg tttcgccatg     6420

ttggccagac tggtctccaa ctcctggcct ctagtgatct gcccgccttg gcttcccaaa     6480

gtgctgggat tacaggcatg agccaccacg cccagcccag ttctgttctt gaccccttcc     6540

ttagccataa tctaacccat atctaaccct gaccctacag ctaactgggg ccccaaactc     6600

aatgctaacc aaatcacccc ttcccagcac agcatgggta atgctcctca ccttcctctg     6660

cccctcagtc ttcctcctta ccgtaggctg tacttcccat gccctagcct ccaattctcc     6720

atcccccgcc caagcagggt cccagtccta tgaggatatg agaggaatcc tgtatgcagc     6780

cccccagctc cgctccattc ggggccagcc tggacccaat catgaggaag gtgggtgctt     6840

ctgccgctgt cccctgctgt cccctgggct gactttgcct tccagcctac ttccagtgcc     6900

acccatgttc tcctcctccc tggtcctatc cagatgcaga ctcttatgag aacatggata     6960

atcccgatgg gccagaccca gcctggggag gagggggccg catgggcacc tggagcacca     7020

ggtgatcctc aggtggccag gtgagctggg actgccccta gggaaagcgg ggagggaggg     7080

agataggcac ggatggcagt ggctgctggc tttcagggag ggagagggaa cagggttcct     7140

agggcctggt gggcaggggg aggactgctg gacccctccc catcaccgtt tcttctgcat     7200

agcctggatc tcctcaagtc cccaagattc acacctgact ctgaaatctg aagacctcga     7260

gcagatgatg ccaacctctg gagcaatgtt gcttaggatg tgtgcatgtg tgtaagtgtg     7320

tgtgtgtgtg tgtgtgtgta tacatgccag tgacacttcc agtccccttt gtattcctta     7380

aataaactca atgagctctt ccaatccta                                       7409


<210>  8
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Ala 
                485                 490                 495     


Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 
            500                 505                 510         


Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 
        515                 520                 525             


Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 
    530                 535                 540                 


Trp Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555         


<210>  9
<211>  3594
<212>  DNA
<213>  Homo sapiens

<400>  9
gtctatcagc gatttcatct tcaggcctgg actacaccac tcaccctccc agtgtgcttg       60

agaaacaaac tgcacccact gaactccgca gctagcatcc aaatcagccc ttgagatttg      120

aggccttgga gactcagatc ctgaacaaga gagaacaaaa tctctacttt gatggaactt      180

ccattctgtg gggaagagac tgacaataag caattaaata aataagaact cagcagtagg      240

ccttgcctca gatccaaggt cactcggaag aggccatgtc taccctcaat gacactcatg      300

gaggaaatgc tgagagaagc attcagatgc atgacacaag gtaagactgc caaaaatctt      360

gttcttgctc tcctcatttt gttatttgtt ttatttttag gagttttgag agcaaaatga      420

caacacccag aaattcagta aatgggactt tcccggcaga gccaatgaaa ggccctattg      480

ctatgcaatc tggtccaaaa ccactcttca ggaggatgtc ttcactggtg ggccccacgc      540

aaagcttctt catgagggaa tctaagactt tgggggctgt ccagattatg aatgggctct      600

tccacattgc cctggggggt cttctgatga tcccagcagg gatctatgca cccatctgtg      660

tgactgtgtg gtaccctctc tggggaggca ttatgtatat tatttccgga tcactcctgg      720

cagcaacgga gaaaaactcc aggaagtgtt tggtcaaagg aaaaatgata atgaattcat      780

tgagcctctt tgctgccatt tctggaatga ttctttcaat catggacata cttaatatta      840

aaatttccca ttttttaaaa atggagagtc tgaattttat tagagctcac acaccatata      900

ttaacatata caactgtgaa ccagctaatc cctctgagaa aaactcccca tctacccaat      960

actgttacag catacaatct ctgttcttgg gcattttgtc agtgatgctg atctttgcct     1020

tcttccagga acttgtaata gctggcatcg ttgagaatga atggaaaaga acgtgctcca     1080

gacccaaatc taacatagtt ctcctgtcag cagaagaaaa aaaagaacag actattgaaa     1140

taaaagaaga agtggttggg ctaactgaaa catcttccca accaaagaat gaagaagaca     1200

ttgaaattat tccaatccaa gaagaggaag aagaagaaac agagacgaac tttccagaac     1260

ctccccaaga tcaggaatcc tcaccaatag aaaatgacag ctctccttaa gtgatttctt     1320

ctgttttctg tttccttttt taaacattag tgttcatagc ttccaagaga catgctgact     1380

ttcatttctt gaggtactct gcacatacgc accacatctc tatctggcct ttgcatggag     1440

tgaccatagc tccttctctc ttacattgaa tgtagagaat gtagccattg tagcagcttg     1500

tgttgtcacg cttcttcttt tgagcaactt tcttacactg aagaaaggca gaatgagtgc     1560

ttcagaatgt gatttcctac taacctgttc cttggatagg ctttttagta tagtattttt     1620

ttttgtcatt ttctccatca acaaccaggg agactgcacc tgatggaaaa gatatatgac     1680

tgcttcatga cattcctaaa ctatcttttt tttattccac atctacgttt ttggtggagt     1740

cccttttgca tcattgtttt aaggatgata aaaaaaaata acaactaggg acaatacaga     1800

acccattcca tttatctttc tacagggctg acattgtggc acattcttag agttaccaca     1860

ccccatgagg gaagctctaa atagccaaca cccatctgtt ttttgtaaaa acagcatagc     1920

ttatacatgg acatgtctct gccttaactt ttcctaactc ccactctagg ctattgtttg     1980

catgtctacc tacttttagc cattatgcga gaaaagaaaa aaatgaccat agaaaatgcc     2040

accatgaggt gcccaaattt caaataataa ttaacattta gttatattta taatttccag     2100

atgacaaagt atttcatcaa ataacttcat ttgatgttcc atgatcaaga aagaatccct     2160

atctctattt tacaagtaat tcaaagaggc caaataactt gtaaacaaga aaaggtaact     2220

tgtcaacagt cataactagt aattatgaga gccttgtttc ataaccaggt cttcttactc     2280

aaatcctgtg atgtttgaaa taaccaaatt gtctctccaa tgtctgcata aactgtgaga     2340

gccaagtcaa cagcttttat caagaattta ctctctgacc agcaataaac aagcactgag     2400

agacacagag agccagattc agattttacc catggggata aaaagactca gactttcacc     2460

acatttggaa aactacttgc atcataaata tataataact ggtagtttat atgaagcaga     2520

cactaagtgc tatagacact ctcagaatat catacttgga aacaatgtaa ttaaaatgcc     2580

gaatctgagt caacagctgc cctacttttc aattcagata tactagtacc ttacctagaa     2640

ataatgttaa cctagggtga agtcactata atctgtagtc tattatttgg gcatttgcta     2700

catgatgagt gctgccagat tgtggcaggt aaagagacaa tgtaatttgc actccctatg     2760

atatttctac atttttagcg accactagtg gaagacattc cccaaaatta gaaaaaaagg     2820

agatagaaga tttctgtcta tgtaaagttc tcaaaatttg ttctaaatta ataaaactat     2880

ctttgtgttc ttttctgcaa cagatgattc caacatgggt gtttgtctat tcttctttac     2940

tcttgaaaca ttagaccatg ggaggctctt acagccttga gttgatattt atacaaccca     3000

aatctaggtt tgaacggtga ggtgtcaggt catcaaatat tcatgtctat atagtcttac     3060

acaggttctc aaaaaaaatg ttcatgggat aggtcattga taatggattc cttattctga     3120

gaactccaga cgactgaaat atatgagaga aggaaaagga catagtagga gcaggcctga     3180

gaaaaaaatg aaagtcagaa atctttaaaa aaatacaaga tcttatttct atcttatttt     3240

ttctcctctt ctgaaatata tatgaggatt cctctccaaa cccatggttt ctctaagaat     3300

tttgagtcat ttgtatgacc tcaaataatt agttttagct gacctcacat aactccttat     3360

aataggagac atctttaatg tctgctatta aagaaggatg aaaattccta tgaccttctc     3420

cccgattatc cctttggcaa tatagagtca aataataaca ttgaccaata gtaaacatgc     3480

tttgccaaga agtagaagat atattctcta gccttagttt ttcctcccaa tttgcatttt     3540

tgtaaaaata atgttgtatc cacaaaggaa ataaacttta aaaacccaag tgca           3594


<210>  10
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  11
<211>  3300
<212>  DNA
<213>  Homo sapiens

<400>  11
acttctcctt ttgctctcag atgctgccag ggtccctgaa gagggaagac acgcggaaac       60

aggcttgcac ccagacacga caccatgcat ctcctcggcc cctggctcct gctcctggtt      120

ctagaatact tggctttctc tgactcaagt aaatgggttt ttgagcaccc tgaaaccctc      180

tacgcctggg agggggcctg cgtctggatc ccctgcacct acagagccct agatggtgac      240

ctggaaagct tcatcctgtt ccacaatcct gagtataaca agaacacctc gaagtttgat      300

gggacaagac tctatgaaag cacaaaggat gggaaggttc cttctgagca gaaaagggtg      360

caattcctgg gagacaagaa taagaactgc acactgagta tccacccggt gcacctcaat      420

gacagtggtc agctggggct gaggatggag tccaagactg agaaatggat ggaacgaata      480

cacctcaatg tctctgaaag gccttttcca cctcatatcc agctccctcc agaaattcaa      540

gagtcccagg aagtcactct gacctgcttg ctgaatttct cctgctatgg gtatccgatc      600

caattgcagt ggctcctaga gggggttcca atgaggcagg ctgctgtcac ctcgacctcc      660

ttgaccatca agtctgtctt cacccggagc gagctcaagt tctccccaca gtggagtcac      720

catgggaaga ttgtgacctg ccagcttcag gatgcagatg ggaagttcct ctccaatgac      780

acggtgcagc tgaacgtgaa gcacaccccg aagttggaga tcaaggtcac tcccagtgat      840

gccatagtga gggaggggga ctctgtgacc atgacctgcg aggtcagcag cagcaacccg      900

gagtacacga cggtatcctg gctcaaggat gggacctcgc tgaagaagca gaatacattc      960

acgctaaacc tgcgcgaagt gaccaaggac cagagtggga agtactgctg tcaggtctcc     1020

aatgacgtgg gcccgggaag gtcggaagaa gtgttcctgc aagtgcagta tgccccggaa     1080

ccttccacgg ttcagatcct ccactcaccg gctgtggagg gaagtcaagt cgagtttctt     1140

tgcatgtcac tggccaatcc tcttccaaca aattacacgt ggtaccacaa tgggaaagaa     1200

atgcagggaa ggacagagga gaaagtccac atcccaaaga tcctcccctg gcacgctggg     1260

acttattcct gtgtggcaga aaacattctt ggtactggac agaggggccc gggagctgag     1320

ctggatgtcc agtatcctcc caagaaggtg accacagtga ttcaaaaccc catgccgatt     1380

cgagaaggag acacagtgac cctttcctgt aactacaatt ccagtaaccc cagtgttacc     1440

cggtatgaat ggaaacccca tggcgcctgg gaggagccat cgcttggggt gctgaagatc     1500

caaaacgttg gctgggacaa cacaaccatc gcctgcgcag cttgtaatag ttggtgctcg     1560

tgggcctccc ctgtcgccct gaatgtccag tatgcccccc gagacgtgag ggtccggaaa     1620

atcaagcccc tttccgagat tcactctgga aactcggtca gcctccaatg tgacttctca     1680

agcagccacc ccaaagaagt ccagttcttc tgggagaaaa atggcaggct tctggggaaa     1740

gaaagccagc tgaattttga ctccatctcc ccagaagatg ctgggagtta cagctgctgg     1800

gtgaacaact ccataggaca gacagcgtcc aaggcctgga cacttgaagt gctgtatgca     1860

cccaggaggc tgcgtgtgtc catgagcccg ggggaccaag tgatggaggg gaagagtgca     1920

accctgacct gtgagagcga cgccaaccct cccgtctccc actacacctg gtttgactgg     1980

aataaccaaa gcctccccta ccacagccag aagctgagat tggagccggt gaaggtccag     2040

cactcgggtg cctactggtg ccaggggacc aacagtgtgg gcaagggccg ttcgcctctc     2100

agcaccctca ccgtctacta tagcccggag accatcggca ggcgagtggc tgtgggactc     2160

gggtcctgcc tcgccatcct catcctggca atctgtgggc tcaagctcca gcgacgttgg     2220

aagaggacac agagccagca ggggcttcag gagaattcca gcggccagag cttctttgtg     2280

aggaataaaa aggttagaag ggcccccctc tctgaaggcc cccactccct gggatgctac     2340

aatccaatga tggaagatgg cattagctac accaccctgc gctttcccga gatgaacata     2400

ccacgaactg gagatgcaga gtcctcagag atgcagagac ctcccccgga ctgcgatgac     2460

acggtcactt attcagcatt gcacaagcgc caagtgggcg actatgagaa cgtcattcca     2520

gattttccag aagatgaggg gattcattac tcagagctga tccagtttgg ggtcggggag     2580

cggcctcagg cacaagaaaa tgtggactat gtgatcctca aacattgaca ctggatgggc     2640

tgcagcagag gcactggggg cagcgggggc cagggaagtc cccgagtttc cccagacacc     2700

gccacatggc ttcctcctgc gcgcatgtgc gcacacacac acacacacgc acacacacac     2760

acacacactc actgcggaga accttgtgcc tggctcagag ccagtctttt tggtgagggt     2820

aaccccaaac ctccaaaact cctgcccctg ttctcttcca ctctccttgc tacccagaaa     2880

tccatctaaa tacctgccct gacatgcaca cctccccctg cccccaccac ggccactggc     2940

catctccacc cccagctgct tgtgtccctc ctgggatctg ctcgtcatca tttttccttc     3000

ccttctccat ctctctggcc ctctacccct gatctgacat ccccactcac gaatattatg     3060

cccagtttct gcctctgagg gaaagcccag aaaaggacag aaacgaagta gaaaggggcc     3120

cagtcctggc ctggcttctc ctttggaagt gaggcattgc acggggagac gtacgtatca     3180

gcggcccctt gactctgggg actccgggtt tgagatggac acactggtgt ggattaacct     3240

gccagggaga cagagctcac aataaaaatg gctcagatgc cacttcaaag aaaaaaaaaa     3300


<210>  12
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  12

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  13
<211>  1413
<212>  DNA
<213>  Mus musculus

<400>  13
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcact      120

tgtactgtct ctggattttc attaaccaac tatggtgtac actgggttcg ccagcctcca      180

ggaaaaggtc tggagtggct gggaatgatt tgggctggtg gaagcacaaa ttataattcg      240

gctctcatgt ccagactgaa catcaacaaa gacaactcca agagccaagt tttcttagaa      300

atgaacagtc tgcaaactga tgacactgcc ttgtacttct gtgccagaga agccacctcg      360

ggctacgtag actatgctgt ggactactgg ggtcaaggaa cgtcagtcac cgtctcctca      420

gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaactggc      480

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      540

tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctgtcct gcagtctgac      600

ctctacaccc tcagcagctc agtgactgta acctcgagca cctggcccag ccagtccatc      660

acctgcaatg tggcccaccc ggcaagcagc accaaggtgg acaagaaaat tgagcccaga      720

gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga      780

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      840

atagtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      900

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac      960

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag     1020

gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca     1080

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag     1140

atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt     1200

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc     1260

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg     1320

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg     1380

actaagagct tctcccggac tccgggtaaa tga                                  1413


<210>  14
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  14
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatatcc       60

agaggacaaa ttattctcaa ccagtctcca gcaatcatgt ctgcatttcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgcactggta ccagcagaag      180

tcaggcacct cccccaaaag atggatttat gacacatcca aattggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttattctc tcacaatcag cagcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta gtagcccgct cacgttcggt      360

gctgggacca agctggagct gaaacgggct gatgctgcac caactgtatc catcttccca      420

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      480

taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      540

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      600

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      660

acatcaactt cacccattgt caagagcttc aacaggaatg agtgttag                   708


<210>  15
<211>  1422
<212>  DNA
<213>  Mus musculus

<400>  15
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctgc agcagtctgg ggctgagctg gtgaggcctg ggtcctcagt gaagatttcc      120

tgcaaggctt ctggctatgc attcagtagc tactggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacagatt tggcctggag atggtgatac taactacaat      240

ggaaagttca agggtaaagc cactctgact gcagacgaat cctccagcac agcctacatg      300

caactcagca gcctagcatc tgaggactct gcggtctatt tctgtgcaag acgggagact      360

acgacggtag gccgttatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag ccaaaacaac agccccatcg gtctatccac tggcccctgt gtgtggagat      480

acaactggct cctcggtgac tctaggatgc ctggtcaagg gttatttccc tgagccagtg      540

accttgacct ggaactctgg atccctgtcc agtggtgtgc acaccttccc agctgtcctg      600

cagtctgacc tctacaccct cagcagctca gtgactgtaa cctcgagcac ctggcccagc      660

cagtccatca cctgcaatgt ggcccacccg gcaagcagca ccaaggtgga caagaaaatt      720

gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc      780

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      840

ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag      900

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      960

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg     1020

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga     1080

accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca     1140

gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct     1200

gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact     1260

gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag     1320

aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat     1380

caccacacga ctaagagctt ctcccggact ccgggtaaat ga                        1422


<210>  16
<211>  750
<212>  DNA
<213>  Mus musculus

<400>  16
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatatcc       60

agaggagata tcttgctcac ccaaactcca gcttctttgg ctgtgtctct agggcagagg      120

gccaccatct cctgcaaggc cagccaaagt gttgattatg atggtgatag ttatttgaac      180

tggtaccaac agattccagg acagccaccc aaactcctca tctatgatgc atccaatcta      240

gtttctggga tcccacccag gtttagtggc agtgggtctg ggacagactt caccctcaac      300

atccatcctg tggagaaggt ggatgctgca acctatcact gtcagcaaag tactgaggat      360

ccgtggacgt tcggtggagg caccaagctg gaaatcaaac gggctgatgc tgcggccgct      420

ggatcccggg ctgatgctgc accaactgta tccatcttcc caccatccag tgagcagtta      480

acatctggag gtgcctcagt cgtgtgcttc ttgaacaact tctaccccaa agacatcaat      540

gtcaagtgga agattgatgg cagtgaacga caaaatggcg tcctgaacag ttggactgat      600

caggacagca aagacagcac ctacagcatg agcagcaccc tcacgttgac caaggacgag      660

tatgaacgac ataacagcta tacctgtgag gccactcaca agacatcaac ttcacccatt      720

gtcaagagct tcaacaggaa tgagtgttag                                       750


<210>  17
<211>  1398
<212>  DNA
<213>  Mus musculus

<400>  17
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtccagctgc agcagtcagg ggctgaactg gtgaaacctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac ctttactagc tactggctgc actggataaa acagaggcct      180

ggacagggtc tggaatggat tggatacatt aatcctagga atgattatac tgagtacaat      240

cagaaattca aggacaaggc cacattgact gcagacaaat cctccagcac agcctatatg      300

caactgagca gcctgacatc tgaggactct gcagtctatt actgcgcgcg aagggatatt      360

actacgttct actggggcca aggcaccact ctcacagtct cctcggccaa aacaacagcc      420

ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta      480

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      540

ctgtccagtg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta caccctcagc      600

agctcagtga ctgtaacctc gagcacctgg cccagccagt ccatcacctg caatgtggcc      660

cacccggcaa gcagcaccaa ggtggacaag aaaattgagc ccagagggcc cacaatcaag      720

ccctgtcctc catgcaaatg cccagcacct aacctcttgg gtggaccatc cgtcttcatc      780

ttccctccaa agatcaagga tgtactcatg atctccctga gccccatagt cacatgtgtg      840

gtggtggatg tgagcgagga tgacccagat gtccagatca gctggtttgt gaacaacgtg      900

gaagtacaca cagctcagac acaaacccat agagaggatt acaacagtac tctccgggtg      960

gtcagtgccc tccccatcca gcaccaggac tggatgagtg gcaaggagtt caaatgcaag     1020

gtcaacaaca aagacctccc agcgcccatc gagagaacca tctcaaaacc caaagggtca     1080

gtaagagctc cacaggtata tgtcttgcct ccaccagaag aagagatgac taagaaacag     1140

gtcactctga cctgcatggt cacagacttc atgcctgaag acatttacgt ggagtggacc     1200

aacaacggga aaacagagct aaactacaag aacactgaac cagtcctgga ctctgatggt     1260

tcttacttca tgtacagcaa gctgagagtg gaaaagaaga actgggtgga aagaaatagc     1320

tactcctgtt cagtggtcca cgagggtctg cacaatcacc acacgactaa gagcttctcc     1380

cggactccgg gtaaatga                                                   1398


<210>  18
<211>  729
<212>  DNA
<213>  Mus musculus

<400>  18
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatatcc       60

agaggagata tccagctgac ccagtctcca tcatctctgg ctgtgtctgc aggagaaaac      120

gtcactatga gctgtaagtc cagtcaaagt gttttataca gtgcaaatca caagaactac      180

ttggcctggt accagcagaa accagggcag tctcctaaac tgctgatcta ctgggcatcc      240

actagggaat ctggtgtccc tgatcgcttc acaggcagcg gatctgggac agattttact      300

cttaccatca gcagagtaca agttgaagac ctggcaattt attattgtca ccaatacctc      360

tcctcgtgga cgttcggtgg cgggaccaag ctggagatca aacgtcgggc tgatgctgca      420

ccaactgtat ccatcttccc accatccagt gagcagttaa catctggagg tgcctcagtc      480

gtgtgcttct tgaacaactt ctaccccaaa gacatcaatg tcaagtggaa gattgatggc      540

agtgaacgac aaaatggcgt cctgaacagt tggactgatc aggacagcaa agacagcacc      600

tacagcatga gcagcaccct cacgttgacc aaggacgagt atgaacgaca taacagctat      660

acctgtgagg ccactcacaa gacatcaact tcacccattg tcaagagctt caacaggaat      720

gagtgttag                                                              729


<210>  19
<211>  1416
<212>  DNA
<213>  Mus musculus

<400>  19
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcaactgc ggcagcctgg ggctgagctg gtgaagcctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac atttaccagt tacaatatgc actgggtaaa gcagacacct      180

ggacagggcc tggaatggat tggagctatt tatccaggaa atggtgatac ttcctacaat      240

cagaagttca aaggcaaggc cacattgact gcagacaaat cctccagcac agcctacatg      300

cagctcagca gtctgacatc tgaggactct gcggtctatt actgtgcaag atcgcactac      360

ggtagtaact acgtagacta ctttgactac tggggccaag gcaccactct cacagtctcc      420

tcagccaaaa caacagcccc atcggtctat ccactggccc ctgtgtgtgg agatacaact      480

ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg      540

acctggaact ctggatccct gtccagtggt gtgcacacct tcccagctgt cctgcagtct      600

gacctctaca ccctcagcag ctcagtgact gtaacctcga gcacctggcc cagccagtcc      660

atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc      720

agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      780

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      840

cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      900

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      960

aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc     1020

aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc     1080

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa     1140

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     1200

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     1260

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1320

tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1380

acgactaaga gcttctcccg gactccgggt aaatga                               1416


<210>  20
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  20
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatatcc       60

agaggacaaa ttgttctctc ccagtctcca gcaatccttt ctgcatctcc aggggagaag      120

gtcacaatga cttgcagggc cagctcaagt ttaagtttca tgcactggta ccagcagaag      180

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag      300

gctgaagatg ctgccactta tttctgccat cagtggagta gtaacccgct cacgttcggt      360

gctgggacaa agctggaact caaacgtcgg gctgatgctg caccaactgt atccatcttc      420

ccaccatcca gtgagcagtt aacatctgga ggtgcctcag tcgtgtgctt cttgaacaac      480

ttctacccca aagacatcaa tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc      540

gtcctgaaca gttggactga tcaggacagc aaagacagca cctacagcat gagcagcacc      600

ctcacgttga ccaaggacga gtatgaacga cataacagct atacctgtga ggccactcac      660

aagacatcaa cttcacccat tgtcaagagc ttcaacagga atgagtgtta g               711


<210>  21
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD21 heavy chain fused to EBNA3C-5H11 epitope

<400>  21
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcact      120

tgtactgtct ctggattttc attaaccaac tatggtgtac actgggttcg ccagcctcca      180

ggaaaaggtc tggagtggct gggaatgatt tgggctggtg gaagcacaaa ttataattcg      240

gctctcatgt ccagactgaa catcaacaaa gacaactcca agagccaagt tttcttagaa      300

atgaacagtc tgcaaactga tgacactgcc ttgtacttct gtgccagaga agccacctcg      360

ggctacgtag actatgctgt ggactactgg ggtcaaggaa cgtcagtcac cgtctcctca      420

gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaactggc      480

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      540

tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctgtcct gcagtctgac      600

ctctacaccc tcagcagctc agtgactgta acctcgagca cctggcccag ccagtccatc      660

acctgcaatg tggcccaccc ggcaagcagc accaaggtgg acaagaaaat tgagcccaga      720

gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga      780

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      840

atagtcacat gtgaaaatcc atatcacgcg cggagaggca taaaagaaca cgtaatcaca      900

tgtgtggtgg tggatgtgag cgaggatgac ccagatgtcc agatcagctg gtttgtgaac      960

aacgtggaag tacacacagc tcagacacaa acccatagag aggattacaa cagtactctc     1020

cgggtggtca gtgccctccc catccagcac caggactgga tgagtggcaa ggagttcaaa     1080

tgcaaggtca acaacaaaga cctcccagcg cccatcgaga gaaccatctc aaaacccaaa     1140

gggtcagtaa gagctccaca ggtatatgtc ttgcctccac cagaagaaga gatgactaag     1200

aaacaggtca ctctgacctg catggtcaca gacttcatgc ctgaagacat ttacgtggag     1260

tggaccaaca acgggaaaac agagctaaac tacaagaaca ctgaaccagt cctggactct     1320

gatggttctt acttcatgta cagcaagctg agagtggaaa agaagaactg ggtggaaaga     1380

aatagctact cctgttcagt ggtccacgag ggtctgcaca atcaccacac gactaagagc     1440

ttctcccgga ctccgggtaa atga                                            1464


<210>  22
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 heavy chain fused to EBNA3C-5H11 epitope

<400>  22
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctgc agcagtctgg ggctgagctg gtgaggcctg ggtcctcagt gaagatttcc      120

tgcaaggctt ctggctatgc attcagtagc tactggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacagatt tggcctggag atggtgatac taactacaat      240

ggaaagttca agggtaaagc cactctgact gcagacgaat cctccagcac agcctacatg      300

caactcagca gcctagcatc tgaggactct gcggtctatt tctgtgcaag acgggagact      360

acgacggtag gccgttatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag ccaaaacaac agccccatcg gtctatccac tggcccctgt gtgtggagat      480

acaactggct cctcggtgac tctaggatgc ctggtcaagg gttatttccc tgagccagtg      540

accttgacct ggaactctgg atccctgtcc agtggtgtgc acaccttccc agctgtcctg      600

cagtctgacc tctacaccct cagcagctca gtgactgtaa cctcgagcac ctggcccagc      660

cagtccatca cctgcaatgt ggcccacccg gcaagcagca ccaaggtgga caagaaaatt      720

gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc      780

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      840

ctgagcccca tagtcacatg tgaaaatcca tatcacgcgc ggagaggcat aaaagaacac      900

gtaatcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      960

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac     1020

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag     1080

gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca     1140

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag     1200

atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt     1260

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc     1320

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg     1380

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg     1440

actaagagct tctcccggac tccgggtaaa tga                                  1473


<210>  23
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD22 heavy chain fused to EBNA3C-5H11 epitope

<400>  23
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtccagctgc agcagtcagg ggctgaactg gtgaaacctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac ctttactagc tactggctgc actggataaa acagaggcct      180

ggacagggtc tggaatggat tggatacatt aatcctagga atgattatac tgagtacaat      240

cagaaattca aggacaaggc cacattgact gcagacaaat cctccagcac agcctatatg      300

caactgagca gcctgacatc tgaggactct gcagtctatt actgcgcgcg aagggatatt      360

actacgttct actggggcca aggcaccact ctcacagtct cctcggccaa aacaacagcc      420

ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta      480

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      540

ctgtccagtg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta caccctcagc      600

agctcagtga ctgtaacctc gagcacctgg cccagccagt ccatcacctg caatgtggcc      660

cacccggcaa gcagcaccaa ggtggacaag aaaattgagc ccagagggcc cacaatcaag      720

ccctgtcctc catgcaaatg cccagcacct aacctcttgg gtggaccatc cgtcttcatc      780

ttccctccaa agatcaagga tgtactcatg atctccctga gccccatagt cacatgtgaa      840

aatccatatc acgcgcggag aggcataaaa gaacacgtaa tcacatgtgt ggtggtggat      900

gtgagcgagg atgacccaga tgtccagatc agctggtttg tgaacaacgt ggaagtacac      960

acagctcaga cacaaaccca tagagaggat tacaacagta ctctccgggt ggtcagtgcc     1020

ctccccatcc agcaccagga ctggatgagt ggcaaggagt tcaaatgcaa ggtcaacaac     1080

aaagacctcc cagcgcccat cgagagaacc atctcaaaac ccaaagggtc agtaagagct     1140

ccacaggtat atgtcttgcc tccaccagaa gaagagatga ctaagaaaca ggtcactctg     1200

acctgcatgg tcacagactt catgcctgaa gacatttacg tggagtggac caacaacggg     1260

aaaacagagc taaactacaa gaacactgaa ccagtcctgg actctgatgg ttcttacttc     1320

atgtacagca agctgagagt ggaaaagaag aactgggtgg aaagaaatag ctactcctgt     1380

tcagtggtcc acgagggtct gcacaatcac cacacgacta agagcttctc ccggactccg     1440

ggtaaatga                                                             1449


<210>  24
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD20 heavy chain fused to EBNA3C-5H11 epitope

<400>  24
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcaactgc ggcagcctgg ggctgagctg gtgaagcctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac atttaccagt tacaatatgc actgggtaaa gcagacacct      180

ggacagggcc tggaatggat tggagctatt tatccaggaa atggtgatac ttcctacaat      240

cagaagttca aaggcaaggc cacattgact gcagacaaat cctccagcac agcctacatg      300

cagctcagca gtctgacatc tgaggactct gcggtctatt actgtgcaag atcgcactac      360

ggtagtaact acgtagacta ctttgactac tggggccaag gcaccactct cacagtctcc      420

tcagccaaaa caacagcccc atcggtctat ccactggccc ctgtgtgtgg agatacaact      480

ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg      540

acctggaact ctggatccct gtccagtggt gtgcacacct tcccagctgt cctgcagtct      600

gacctctaca ccctcagcag ctcagtgact gtaacctcga gcacctggcc cagccagtcc      660

atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc      720

agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      780

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      840

cccatagtca catgtgaaaa tccatatcac gcgcggagag gcataaaaga acacgtaatc      900

acatgtgtgg tggtggatgt gagcgaggat gacccagatg tccagatcag ctggtttgtg      960

aacaacgtgg aagtacacac agctcagaca caaacccata gagaggatta caacagtact     1020

ctccgggtgg tcagtgccct ccccatccag caccaggact ggatgagtgg caaggagttc     1080

aaatgcaagg tcaacaacaa agacctccca gcgcccatcg agagaaccat ctcaaaaccc     1140

aaagggtcag taagagctcc acaggtatat gtcttgcctc caccagaaga agagatgact     1200

aagaaacagg tcactctgac ctgcatggtc acagacttca tgcctgaaga catttacgtg     1260

gagtggacca acaacgggaa aacagagcta aactacaaga acactgaacc agtcctggac     1320

tctgatggtt cttacttcat gtacagcaag ctgagagtgg aaaagaagaa ctgggtggaa     1380

agaaatagct actcctgttc agtggtccac gagggtctgc acaatcacca cacgactaag     1440

agcttctccc ggactccggg taaatga                                         1467


<210>  25
<211>  470
<212>  PRT
<213>  Mus musculus

<400>  25

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Asn Ile Asn Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Glu Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Leu Tyr 
            100                 105                 110         


Phe Cys Ala Arg Glu Ala Thr Ser Gly Tyr Val Asp Tyr Ala Val Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  26
<211>  235
<212>  PRT
<213>  Mus musculus

<400>  26

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Gln Ile Ile Leu Asn Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Phe Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Ser Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  27
<211>  473
<212>  PRT
<213>  Mus musculus

<400>  27

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp 
145                 150                 155                 160 


Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  28
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  28

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Asp Ile Leu Leu Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln 
    50                  55                  60                  


Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
65                  70                  75                  80  


Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr 
            100                 105                 110         


His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Ala Ala Gly Ser Arg Ala 
    130                 135                 140                 


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
145                 150                 155                 160 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
                165                 170                 175     


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
            180                 185                 190         


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
        195                 200                 205             


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
    210                 215                 220                 


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
225                 230                 235                 240 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
                245                 


<210>  29
<211>  465
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
225                 230                 235                 240 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
            260                 265                 270         


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
        275                 280                 285             


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
    290                 295                 300                 


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
305                 310                 315                 320 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
                325                 330                 335     


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
            340                 345                 350         


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
        355                 360                 365             


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
    370                 375                 380                 


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
385                 390                 395                 400 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
            420                 425                 430         


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
        435                 440                 445             


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  30
<211>  242
<212>  PRT
<213>  Mus musculus

<400>  30

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Val Ser Ala Gly Glu Asn Val Thr Met Ser Cys Lys Ser Ser 
        35                  40                  45              


Gln Ser Val Leu Tyr Ser Ala Asn His Lys Asn Tyr Leu Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Gln Val Glu Asp Leu Ala 
            100                 105                 110         


Ile Tyr Tyr Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Arg Ala Asp Ala Ala Pro Thr Val Ser 
    130                 135                 140                 


Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val 
145                 150                 155                 160 


Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp 
                165                 170                 175     


Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr 
            180                 185                 190         


Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala 
    210                 215                 220                 


Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn 
225                 230                 235                 240 


Glu Cys 
        


<210>  31
<211>  471
<212>  PRT
<213>  Mus musculus

<400>  31

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Arg Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser His Tyr Gly Ser Asn Tyr Val Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
        355                 360                 365             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
    370                 375                 380                 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
385                 390                 395                 400 


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
                405                 410                 415     


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
        435                 440                 445             


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
    450                 455                 460                 


Phe Ser Arg Thr Pro Gly Lys 
465                 470     


<210>  32
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  32

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Leu Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Phe Cys His Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                165                 170                 175     


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
        195                 200                 205             


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
    210                 215                 220                 


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235     


<210>  33
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD21 heavy chain fused to EBNA3C-5H11 epitope

<400>  33

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Asn Ile Asn Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Glu Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Leu Tyr 
            100                 105                 110         


Phe Cys Ala Arg Glu Ala Thr Ser Gly Tyr Val Asp Tyr Ala Val Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Glu Asn Pro Tyr 
        275                 280                 285             


His Ala Arg Arg Gly Ile Lys Glu His Val Ile Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  34
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 heavy chain fused to EBNA3C-5H11 epitope

<400>  34

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp 
145                 150                 155                 160 


Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
        195                 200                 205             


Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Glu 
        275                 280                 285             


Asn Pro Tyr His Ala Arg Arg Gly Ile Lys Glu His Val Ile Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
305                 310                 315                 320 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                325                 330                 335     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            340                 345                 350         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        355                 360                 365             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    370                 375                 380                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
385                 390                 395                 400 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                405                 410                 415     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            420                 425                 430         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        435                 440                 445             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    450                 455                 460                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
465                 470                 475                 480 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490 


<210>  35
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD22 heavy chain fused to EBNA3C-5H11 epitope

<400>  35

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
225                 230                 235                 240 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
            260                 265                 270         


Leu Ser Pro Ile Val Thr Cys Glu Asn Pro Tyr His Ala Arg Arg Gly 
        275                 280                 285             


Ile Lys Glu His Val Ile Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  36
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD20 heavy chain fused to EBNA3C-5H11 epitope

<400>  36

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Arg Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser His Tyr Gly Ser Asn Tyr Val Asp Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr 
145                 150                 155                 160 


Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
225                 230                 235                 240 


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
                245                 250                 255     


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Glu Asn Pro 
        275                 280                 285             


Tyr His Ala Arg Arg Gly Ile Lys Glu His Val Ile Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
305                 310                 315                 320 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
                325                 330                 335     


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
            340                 345                 350         


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
    370                 375                 380                 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
385                 390                 395                 400 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
                405                 410                 415     


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
            420                 425                 430         


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
        435                 440                 445             


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
    450                 455                 460                 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
465                 470                 475                 480 


Ser Phe Ser Arg Thr Pro Gly Lys 
                485             


<210>  37
<211>  372
<212>  DNA
<213>  Mus musculus

<400>  37
caggtgcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttggcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtaa agccactctg actgcagacg aatcctccag cacagcctac      240

atgcaactca gcagcctagc atctgaggac tctgcggtct atttctgtgc aagacgggag      300

actacgacgg taggccgtta ttactatgct atggactact ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  38
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  38
gatatcttgc tcacccaaac tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      120

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      180

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggaga aggtggatgc tgcaacctat cactgtcagc aaagtactga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgg                                336


<210>  39
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  39
caggtccagc tgcaggagtc aggggctgaa ctgtcaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact agctactggc tgcactggat aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta ggaatgatta tactgagtac      180

aatcagaact tcaaggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagaagggat      300

attactacgt tctactgggg ccaaggcacc actctcacag tctcctcg                   348


<210>  40
<211>  300
<212>  DNA
<213>  Mus musculus

<400>  40
gatatccagc tgacccagtc tccatcatct ctggctgtgt ctgcaggaga aaacgtcact       60

atgagctgta agtccagtca aagtgtttta tacagtgcaa atcacaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctggtg tccctgatcg cttcacaggc agcggatctg ggacagattt tactcttacc      240

atcagcagag tacaagttga agacctggca atttattatt gtcaccaata cctctcctcg      300


<210>  41
<211>  366
<212>  DNA
<213>  Mus musculus

<400>  41
caggtgcaac tgcggcagcc tggggctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt aaagcagaca      120

cctggacagg gcctggaatg gattggagct atttatccag gaaatggtga tacttcctac      180

aatcagaagt tcaaaggcaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagtctgac atctgaggac tctgcggtct attactgtgc aagatcgcac      300

tacggtagta actacgtaga ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  42
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  42
caaattgttc tctcccagtc tccagcaatc ctttctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtttaagt ttcatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttatttctg ccatcagtgg agtagtaacc cgctcacgtt cggtgctggg      300

acaaagctgg aactcaaacg t                                                321


<210>  43
<211>  14
<212>  PRT
<213>  Human herpesvirus 4

<400>  43

Val Val Arg Met Phe Met Arg Glu Arg Gln Leu Pro Gln Ser 
1               5                   10                  


